UNITED
STATES

SECURITIES
AND EXCHANGE COMMISSION

WASHINGTON,
D.C. 20549

_________________________



FORM
10-K/A

Amendment
No. 1



xANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934



FOR THE FISCAL YEAR ENDED DECEMBER 31,
2012, OR



 ̈TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d)OF THE SECURITIES EXCHANGE ACT OF 1934



FOR THE TRANSITION PERIOD FROM __________TO__________



Commission file number 000-51462

_________________________



CHELSEA
THERAPEUTICS INTERNATIONAL, LTD.

(Exact name of Registrant as specified
in its charter)



|Delaware                        |  | 20-3174202                          
|------------------------------- |  | ------------------------------------
|(State or other jurisdiction of |  | (I.R.S. Employer Identification No.)
|incorporation or organization)  |  |                                     



3530 Toringdon Way, Suite 200, Charlotte,
North Carolina 28277(Address of principal executive offices, including zip code)



(704) 341-1516(Registrant’s telephone number, including area code)

__________________________



Securities registered pursuant to Section
12(b) of the Act:



|Title
    of each class         | Name
    of each exchange on which registered
|------------------------------- | ---------------------------------------------
|Common Stock, $0.0001 Par Value | Nasdaq Capital Market                        



Securities registered pursuant to Section
12(g) of the Act:

None

Indicate by check mark if the Registrant is a well-known seasoned
issuer (as defined in Rule 405 of the Securities Act).

Yes  ̈  No x



Indicate by check mark if the Registrant is not required to
file reports pursuant to Section 13 or Section 15(d) of the Act.

Yes  ̈   No x



Indicate by check mark whether the Registrant (1) has filed
all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934, as amended, during the preceding
12 months (or for such shorter period that the Registrant was required to file such reports), and (2) has been subject to such

filing requirements for the past 90 days. Yes x   No  ̈



Indicate by check mark whether the Registrant has submitted
electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant
to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the Registrant was required to submit
and post such files).

Yes x   No  ̈



Indicate by check mark if disclosure of delinquent filers pursuant
to Item 405 of Regulation S-K is not contained herein, and will not be contained, to the best of Registrant's knowledge, in definitive
proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this

Form 10-K. x



Indicate by check mark whether the Registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated
filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act (Check
one):

| | Large accelerated filer  ̈ |  | Accelerated filer x        
| | ------------------------- |  | ---------------------------
| | Non-accelerated filer  ̈   |  | Smaller reporting company  ̈



Indicate by check mark whether the Registrant is a shell company
(as defined in Rule 12b-2 of the Act). Yes  ̈   No x



The aggregate market value of the Registrant’s common
stock held by non-affiliates of the Registrant, based on the closing price of the Registrant’s common stock on June 29,
2012 ($1.48 per share) was approximately $85,000,000. This determination of affiliate status is not necessarily a conclusive determination
for other purposes.



At March 5, 2013, 67,075,779 shares of the Registrant's common
stock, $.0001 par value per share, were outstanding.



Documents Incorporated By Reference



Portions of the Registrant’s definitive Proxy Statement
to be filed for its 2013 Annual Meeting of Stockholders are incorporated by reference into Part III of this report.













EXPLANATORY NOTE



Chelsea Therapeutics International, Ltd. (the “Company”)
is filing this Amendment No. 1 to its Annual Report on Form 10-K for the fiscal year ended December 31, 2012, filed with the Securities
and Exchange Commission (the “SEC”) on March 7, 2013 for the sole purpose of adding the electronic signature of the
Company’s independent registered public accounting firm, Ernst & Young LLP, to the Report of Independent Registered Public
Accounting Firm for the consolidated financial statements and the financial statements schedule listed in the Index at Item 15,
and the effectiveness of the Company’s internal control over financial reporting. These signatures were inadvertently omitted
from the previously filed Form 10-K.



Although compliance with certain requirements of the SEC’s
rules in connection with the filing of this Amendment on Form 10-K/A allows the company to file only those sections affected by
the amendment, this amendment includes a complete resubmission of the entire Annual Report on Form 10-K, as amended. This Amendment
No. 1 on Form 10-K/A does not change or update the previously reported financial statements or any of the other disclosures contained
in the original Form 10-K.



Consistent with the rules of the SEC, the certifications of
the Company’s principal executive officer and principal financial officer, required by Sections 302 and 906 of the Sarbanes-Oxley
Act of 2002, as of the date of this Amendment No. 1 on Form 10-K/A are attached as exhibits to this Amendment No. 1 on Form 10-K/A.
The only change in these certifications is their date.













ANNUAL REPORT ON FORM 10-K



Table of Contents



|           |                                                                                                                  | Page
|---------- | ---------------------------------------------------------------------------------------------------------------- | ----
|           | PART I                                                                                                           |     
|           |                                                                                                                  |     
|Item 1.    | Business                                                                                                         | 1   
|           |                                                                                                                  |     
|Item 1A.   | Risk Factors                                                                                                     | 19  
|           |                                                                                                                  |     
|Item 1B.   | Unresolved Staff Comments                                                                                        | 31  
|           |                                                                                                                  |     
|Item 2.    | Properties                                                                                                       | 31  
|           |                                                                                                                  |     
|Item 3.    | Legal Proceedings                                                                                                | 31  
|           |                                                                                                                  |     
|Item 4.    | Mine Safety Disclosures                                                                                          | 32  
|           |                                                                                                                  |     
|           | PART II                                                                                                          |     
|           |                                                                                                                  |     
|Item 5.    | Market for Registrant's Common Equity, Related Stockholder Matters
    and Issuer Purchases of Equity Securities | 32  
|           |                                                                                                                  |     
|Item 6.    | Selected Consolidated Financial Data                                                                             | 33  
|           |                                                                                                                  |     
|Item 7.    | Management's Discussion and Analysis of Financial Condition
    and Results of Operations                        | 34  
|           |                                                                                                                  |     
|Item 7A.   | Quantitative and Qualitative Disclosures about Market Risk                                                       | 49  
|           |                                                                                                                  |     
|Item 8.    | Financial Statements and Supplementary Data                                                                      | 49  
|           |                                                                                                                  |     
|Item 9.    | Changes in and Disagreements with Accountants on Accounting
    and Financial Disclosure                         | 50  
|           |                                                                                                                  |     
|Item 9A.   | Controls and Procedures                                                                                          | 50  
|           |                                                                                                                  |     
|Item 9B.   | Other Information                                                                                                | 52  
|           |                                                                                                                  |     
|           | PART III                                                                                                         |     
|           |                                                                                                                  |     
|Item 10.   | Directors, Executive Officers and Corporate Governance                                                           | 53  
|           |                                                                                                                  |     
|Item 11.   | Executive Compensation                                                                                           | 53  
|           |                                                                                                                  |     
|Item 12.   | Security Ownership of Certain Beneficial Owners and Management
    and Related Stockholder Matters               | 53  
|           |                                                                                                                  |     
|Item 13.   | Certain Relationships and Related Transactions, and Director
    Independence                                    | 53  
|           |                                                                                                                  |     
|Item 14.   | Principal Accounting Fees and Services                                                                           | 53  
|           |                                                                                                                  |     
|           | PART IV                                                                                                          |     
|           |                                                                                                                  |     
|Item 15.   | Exhibits and Financial Statement Schedules                                                                       | 54  
|           |                                                                                                                  |     
|SIGNATURES | 57                                                                                                              











PART I



Except for the historical information contained herein,
the matters set forth in this Report include forward-looking statements within the meaning of the “safe harbor” provisions
of the Private Securities Litigation Reform Act of 1995. These forward-looking statements are subject to risks and uncertainties
that may cause actual results to differ materially. These risks and uncertainties are detailed throughout the report and will
be further discussed from time to time in our periodic reports filed with the Securities and Exchange Commission. The forward-looking
statements included in this Report speak only as of the date hereof.



| | ITEM 1. | BUSINESS.
| | ------- | ---------



Overview



We are a development stage pharmaceutical company that seeks
to acquire, develop and commercialize innovative products for the treatment of a variety of human diseases. Our strategy is to
develop technologies that address important unmet medical needs or offer improved alternatives to current methods of treatment.
Specifically, we are developing NortheraTM (droxidopa), a novel therapeutic agent, for the treatment of symptomatic neurogenic
orthostatic hypotension, or Neurogenic OH, in patients with primary autonomic failure (Parkinson’s disease, or PD, multiple
systems atrophy, or MSA, and pure autonomic failure, or PAF), dopamine-β-hydroxylase, or DBH, deficiency and non-diabetic
autonomic neuropathy. We are also evaluating the potential therapeutic applications of droxidopa in reducing the frequency of
falls in patients with Neurogenic OH associated with PD as well as other potentially norepinephrine-related conditions and diseases
including intradialytic hypotension, fibromyalgia and adult attention deficit hyperactivity disorder. In addition, we have a portfolio
of metabolically inert antifolates that we have studied as a potential treatment of rheumatoid arthritis and that might also be
suitable for the treatment of multiple other autoimmune disorders including psoriasis, Crohn’s disease, uveitis, ankylosing
spondylitis, inflammatory bowel disease, cancer and other immunological disorders.



Product Pipeline Highlights



NortheraTM (droxidopa), our most advanced investigational
product candidate, is an orally active synthetic precursor of norepinephrine. Northera is being developed for the treatment of
symptomatic Neurogenic OH in primary autonomic failure (PD, MSA and PAF), DBH deficiency and non-diabetic autonomic neuropathy.
Northera has also been studied in a Phase III trial evaluating its effect on reducing falls in patients with Neurogenic OH associated
with PD. In 2007, the U.S. Food and Drug Administration, or FDA, granted orphan drug status to Northera for the treatment of symptomatic
Neurogenic OH and the European Medicines Agency, or EMA, granted orphan medicinal product designation for the treatment of orthostatic
hypotension in patients with PAF and MSA.



In Japan, droxidopa has been approved since 1989 and is marketed
by Dainippon Sumitomo Pharma Co., Ltd., or DSP, for the treatment of frozen gait and dizziness on standing in PD, orthostatic
hypotension, syncope and dizziness on standing in MSA (Shy-Drager Syndrome) and familial amyloid polyneuropathy and symptoms of
orthostatic hypotension in hemodialytic patients. In May 2006, we entered into an agreement with DSP for an exclusive, sub-licensable
license and rights to droxidopa including, but not limited to all information, formulations, materials, data, drawings, sketches,
designs, testing and test results, records and regulatory documentation.



In addition to our clinical and registration programs for Northera,
we continue to have interest in additional therapeutic applications for droxidopa, both as a monotherapy and in combination with
dopa decarboxylase inhibitors, such as carbidopa. However, at this time, we are limiting our involvement in the exploration of
these additional indications to the support of investigator-led Phase II trials.



In addition to droxidopa, we have devoted resources to the
development of a portfolio of molecules for the treatment of various autoimmune/inflammatory diseases. The most advanced platform
is a portfolio of metabolically-inert antifolate molecules engineered to have potent anti-inflammatory and anti-tumor activity
to treat a range of immunological disorders, including two clinical stage product candidates designated as CH-1504 and CH-4051.



While management believes that further studies might provide
evidence of enhanced therapeutic benefit in rheumatoid arthritis and that CH-4051 could be developed for other anti-inflammatory
and autoimmune indications, we determined that current resources would be better allocated toward the planned completion of the
Northera development program in Neurogenic OH. As such, there are no immediate plans to continue the development of CH-4051 although
we do continue to pursue potential out-licensing opportunities for this portfolio of molecules.



1







Complementing our autoimmune/inflammatory program is a second
platform consisting of a portfolio of therapeutics targeting immune-mediated inflammatory disorders and transplantation, known
as our I-3D portfolio. We currently have no work underway related to this portfolio.



To date, we have not received approval for the sale of any
of our drug candidates in any market and, therefore, have not generated any revenues from our drug candidates.



Our Strategy



Our mission is to create long-term stockholder value by acquiring,
developing and commercializing innovative products for the treatment of a variety of human diseases that address important unmet
medical needs or offer improved, cost-effective alternatives to current methods of treatment. Since inception in 2002, we have
focused primarily on organizing and staffing our company, negotiating in-licensing agreements with our partners, raising capital,
acquiring, developing and securing our proprietary technology, participating in regulatory discussions with the FDA, the EMA and
other regulatory agencies and undertaking preclinical and clinical trials of our product candidates. We are a development stage
company and have generated no revenues since inception. We do not anticipate generating any product revenue until and unless we
successfully obtain approval from the FDA or equivalent foreign regulatory bodies to begin selling Northera or any of our other
pharmaceutical candidates although we could potentially generate revenue prior to any marketing approval by entering into strategic
agreements including out-licensing, co-development or co-promotion of our drug candidates. Currently, operating expenses are being
funded with proceeds from equity financings and, to a much lesser extent, through the issuance of our common stock pursuant to
option or warrant exercises.



Our primary focus remains on our efforts to obtain marketing approval for Northera in Neurogenic OH. We
recently announced guidance from the FDA on a resubmission of our New Drug Application, or NDA, for Northera. We are actively engaged
in preparations for resubmitting our Northera NDA and anticipate that it can be submitted in the second quarter of 2013. Given
that the FDA could grant approval with a commitment to conduct a post-approval efficacy study or require an additional efficacy
study pre-approval, as well as the uncertainty of a near-term approval, we intend to discuss with the FDA a new clinical trial
that would meet their requirements under either scenario. At the same time, we continue to explore partnering opportunities that
can address the resource requirements of both an additional efficacy study and commercialization of Northera.



We also continue to pursue out-licensing opportunities for
our antifolate program with potential partners to gauge their interest in licensing this library of compounds. We believe a partner,
with access to more significant resources, may be able to manage the necessary additional trials and potential global commercialization
efforts more effectively and with less risk than we could and, accordingly, our current strategy is to pursue such a partnership.
Similarly, our Board of Directors continues to evaluate all available strategic options, with the goal of maximizing shareholder
value including potential licensing and/or partnering arrangements for Northera in North America, Europe and other markets. Any
such partnership would aim to provide significant value to us and our stockholders, while maximizing the opportunities for Northera
in global markets. Finally, we continue to pursue and evaluate potential out-licensing arrangements for our I-3D portfolio of
DHODH inhibiting compounds.



We have retained a management team with leading core competencies and expertise in numerous fields, including
manufacturing, clinical drug development, regulatory affairs, finance and business development. We also maintain relationships
with advisors with expertise in Neurogenic OH, some of which had been previously engaged in the planning for our 2012
anticipated launch of Northera. Our management and advisors are comprised of experienced pharmaceutical and biotechnology industry
veterans and respected experts.



Plan of Operation



Our current plan of operation is to continue pursuit of marketing
approval in the US for Northera as a treatment for Neurogenic OH. We continue to evaluate opportunities to further the clinical
development of our other current drug candidates including droxidopa for other indications. Also, as we have in the past, we plan
to continue evaluating the feasibility of expanding our drug candidate portfolio, as resources permit, by acquiring the rights
to other licensed or newly developed compounds or drug technologies for development. We expect our principal expenditures during
2013 to include:



2







| | · | operating expenses,
                                                                                                           including general and
                                                                                                           administrative and
                                                                                                           business development
                                                                                                           expenses; and
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | product development
                                                                                                           expenses, including
                                                                                                           the costs for re-filing
                                                                                                           our Northera NDA and
                                                                                                           for initiating a new
                                                                                                           clinical trial for
                                                                                                           Northera.
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



In July 2012, we announced that the Board of
Directors implemented a restructuring of the Company, including a reduction in force, executive changes and changes to the
Board of Directors. Only those employees and positions deemed necessary to gain marketing authorization for Northera in the
U.S. were retained. As such, given current staffing needs, hiring would be limited to replacing any of those positions made
vacant due to attrition. In addition, we intend to continue using clinical research organizations, or CRO, and third parties
to perform our clinical studies and manufacturing.



Corporate History



Our operating company was incorporated in Delaware in April
2002 under the name Aspen Therapeutics, Inc., and changed its name to Chelsea Therapeutics, Inc. in July 2004. On February 11,
2005, Chelsea Therapeutics, Inc. completed a merger with Ivory Capital Corporation, a publicly traded Colorado corporation formed
in May 1988. At the time of the transaction, Ivory Capital had only nominal assets and no operating activities. In connection
with this merger transaction, a wholly owned subsidiary of Ivory Capital Corporation merged with and into Chelsea Therapeutics,
Inc., with Chelsea Therapeutics, Inc. remaining as the surviving corporation and a wholly owned subsidiary of Ivory Capital Corporation.
In connection with the merger, the former stockholders of Chelsea Therapeutics, Inc. received 96.75% percent of our outstanding
equity on a fully diluted basis. Pursuant to the terms of the merger, the sole officer and director of Ivory Capital Corporation
prior to the merger was replaced with the officers and directors of Chelsea Therapeutics, Inc.



On June 17, 2005, Ivory Capital Corporation formed a wholly
owned subsidiary in Delaware named Chelsea Therapeutics International, Ltd. for the purposes of reincorporating in Delaware. On
July 28, 2005, Ivory Capital Corporation merged with Chelsea Therapeutics International, Ltd., with Chelsea Therapeutics International,
Ltd. as the surviving corporation. As a result, Chelsea Therapeutics International, Ltd. is the public reporting company and is
the 100% owner of Chelsea Therapeutics, Inc., its operating subsidiary.



Except where the context provides otherwise, references to
“we,” “us,” “our” and similar terms mean Chelsea Therapeutics International, Ltd., Ivory Capital
Corporation and Chelsea Therapeutics, Inc. When we refer to business and financial information relating to periods prior to December
31, 2004, we are referring to the business and financial information of Chelsea Therapeutics, Inc. unless the context requires
otherwise. When we refer to business and financial information for periods between January 1, 2005 and July 28, 2005, we are referring
to the business and financial information of Ivory Capital Corporation.



Products Under Development



DROXIDOPA



Product Overview



Droxidopa, a synthetic amino acid, is converted by the body
into norepinephrine and, as a prodrug of norepinephrine, provides replacement therapy for norepinephrine deficiency. Norepinephrine
is both a hormone and a neurotransmitter. As a hormone, secreted by the adrenal gland, it works alongside epinephrine/adrenaline
to give the body sudden energy in times of stress, known as the "fight or flight" response. As a neurotransmitter, it
passes nerve impulses from one neuron to the next. While norepinephrine, as a catecholamine, does not penetrate the blood-brain
barrier, droxidopa, as a neutral amino acid, is able to do so thus providing both a peripheral and central effect on circulating
norepinephrine levels. By producing and replenishing depleted norepinephrine via endogenous enzymatic pathways, droxidopa is believed
to allow for the re-uptake of norepinephrine into peripheral and central nervous system neurons.



Droxidopa is currently approved and marketed by DSP in Japan
for the treatment of frozen gait and dizziness on standing in PD, orthostatic hypotension, syncope and dizziness on standing in
MSA (Shy-Drager Syndrome) and familial amyloid polyneuropathy and symptoms of orthostatic hypotension in hemodialytic patients.
Receiving initial Japanese marketing approval in 1989, droxidopa has historically generated annual revenues of up to approximately
$50 million in Japan. In addition to the indications studied by DSP and subsequently approved in Japan, diseases that may potentially
be treated with droxidopa include fibromyalgia, Attention Deficit Hyperactivity Disorder, or ADHD and other indications in which
norepinephrine deficiencies are believed to play a role.



3







Clinical Development



We have focused on the clinical development of droxidopa in
symptomatic Neurogenic OH, the reduction of falls related to Neurogenic OH in PD, the treatment of fibromyalgia and IDH. In order
to maximize the potential therapeutic applications of droxidopa while conserving capital, we have also provided support to several
investigator-led studies of droxidopa, including a study completed in 2011 in ADHD and a study completed in 2012 for hypotension
related to spinal cord injury. We plan to continue exploring opportunities to support additional, investigator-led studies of
droxidopa in indications for which we believe a strong clinical rationale exists. Given the extensive body of clinical data generated
from our studies and data available to us under the terms of our licensing agreement with DSP, we continue to pursue marketing
approval of droxidopa, under the brand name NortheraTM, in the United States, and plan to follow that by seeking
similar approval in the European Union, for the treatment of symptomatic Neurogenic OH in patients with primary autonomic failure,
an indication for which the drug has been approved in Japan since 1989.



Neurogenic Orthostatic Hypotension



Orthostatic hypotension is a sustained decrease in blood pressure
when a person assumes a standing position and is characterized by lightheadedness, dizziness, blurred vision and syncope. There
are multiple known causes for orthostatic hypotension including those that are considered cardiovascular, endocrine and neurological
(or neurogenic) in nature. Orthostatic hypotension that is neurogenic in nature results from a deficient release and/or synthesis
of norepinephrine, a neurotransmitter used by autonomic nerves to send signals to the blood vessels and the heart. This condition
is commonly associated with PD, PAF and MSA, and has a significant impact on sufferers’ quality of life, with some patients
unable to stand unaided for more than a few minutes a day.



In January 2007, the FDA granted orphan drug status
for Northera for the treatment of symptomatic Neurogenic OH in patients with PAF, DBH deficiency and non-diabetic
autonomic neuropathy. In the United States, orphan drug status provides seven years of marketing exclusivity. In August 2007,
the EMA granted two orphan medicinal product designations for Northera for the treatment of orthostatic hypotension in
patients with PAF and MSA, respectively. Although we can expect 10 years of data exclusivity for droxidopa upon approval in
Europe as a new chemical entity, orphan medicinal product status could impact regulatory approval requirements in Europe,
potentially impacting the time and costs associated with our development of Northera for this market.



Following receipt of the complete response letter, or
CRL, from the FDA in March 2012 more fully described below, we have been working with the FDA to clarify the requirements for
obtaining U.S. marketing approval for Northera. To obtain further clarity from the FDA, we
utilized a formal appeals process that involved the review of the issues presented in the CRL and all other subsequent
guidance received from the FDA. The review was led by the Director for the Center for New Drugs and included other senior
officials within the FDA, including representatives from the Center for Drug Evaluation I along with officials from the FDA
Cardiovascular and Renal Drug Products Division, or CRDP. In February 2013, following the receipt of written guidance
from the FDA related to the January review, we were able to provide an update on our plans to move forward with our Northera
registration program. The FDA has acknowledged that we may utilize efficacy and safety data from Study 306B  to submit a
Northera New Drug Application, or NDA, for review by the CRDP. As such, we plan to resubmit the Northera NDA to the FDA,
seeking approval to market Northera for the treatment of Neurogenic OH in patients with primary autonomic failure (including
PD, MSA and PAF), DBH deficiency and non-diabetic autonomic neuropathy. The resubmission of the Northera NDA will include
data from our completed Phase III efficacy studies (Studies 301, 302, 306A and 306B), an integrated summary of efficacy, an
expanded, 650-patient safety database, two long-term, open label extension studies, a dedicated thorough QTc study and a
24-hour ambulatory blood pressure monitoring study. The FDA has further informed us that an acute symptomatic endpoint,
one demonstrating short-term therapeutic benefit, may be sufficient evidence of efficacyrequired for approval and that durability of response, as measured by long-term symptomatic benefit, may be shown in a
post-approval study.



While this updated guidance is encouraging, the FDA was
clear that Study 306B data remains subject to scrutiny, including careful review of data sensitivities and possible audits of
clinical sites, the CRO involved in the study and the sponsor. Approval using Study 306B as an additional efficacy study
would only be possible based on the strength of that study and its ability to provide substantial evidence of effectiveness.
Given this perspective, we anticipate that the FDA will review the study data thoroughly. Notwithstanding their otherwise
favorable guidance, the FDA is under no obligation to accept the resubmitted Northera NDA for review and, if accepted,
approve Northera if they are not adequately satisfied.



4







While the FDA’s guidance re-establishes the opportunity
to file for the approval of Northera in the near term, we cannot provide any assurance that the FDA will approve Northera without
additional clinical evidence. Moreover, the FDA may choose to approve Northera with a requirement for a post-approval efficacy
study. Accordingly, we plan to initiate an additional clinical study of Northera in Neurogenic OH, the design of which will be
finalized following additional discussions with the FDA. We anticipate that initial patient enrollment and dosing in this study
would begin in the fourth quarter of 2013.



The receipt of the CRL in March 2012 followed a
September 2011 submission and a November 2011 acceptance of our initial Northera NDA. In February 2012, a meeting of the
Cardiovascular and Renal Drugs Advisory Committee, or CRDAC, was held, at the request of the FDA, to review and discuss the
Northera NDA. The CRDAC recommended, in a 7 to 4 vote, that the FDA approve our NDA to market Northera in the United
States. Notwithstanding that recommendation, on March 28, 2012, the FDA issued the CRL regarding our Northera NDA. The CRL
included a request by the FDA that we submit data from an additional positive study to support efficacy and, at that time,
the FDA recommendations suggested that such a study be designed to demonstrate durability of effect over a 2- to 3-month
period. Subsequent discussions with the CRDP and the Office of Drug Evaluation I in 2012 suggested that study 306B might
not be acceptable based on the theoretical potential for un-blinding. However, as discussed above, the FDA has now
provided guidance that data from Study 306B may be utilized for a re-submission of the Northera NDA to seek marketing
approval in the United States. The FDA noted that data strongly demonstrating a short-term clinical benefit (e.g., improvement in
symptoms or ability to function) of droxidopa in patients with Neurogenic OH would be adequate for approval, with a possible
requirement to verify durable clinical benefit post-approval.



Prior to our NDA filing in September 2011, we had completed
two Phase III efficacy trials, Studies 301 and 302, of Northera for the treatment of symptomatic Neurogenic OH in patients with
primary autonomic failure. The improvements in the symptoms of Neurogenic OH, as measured by the orthostatic hypotension questionnaire
composite score, or OHQ composite, associated with Northera treatment in our pivotal efficacy Study 301 are highly significant
(p<0.003). Northera showed similar improvements (p<0.05) in OHQ composite scores in a post-hoc analysis of Study 302 data.
We also had completed a QTc study. A QT interval is a measure of the time between the start of the Q wave and the end of the T
wave in the heart's electrical cycle. In general, a prolonged
QT interval is a biomarker for ventricular tachyarrhythmias and can be a risk factor for sudden death.



Given the concerns raised by the FDA at the
End-of-Review meeting, or EOR, held in May 2012, regarding results from the highest enrolling site in Study 301, we submitted
all information pertaining to two independent site visits, neither of which revealed any significant errors in the conduct of
the trial, which was consistent with the positive findings from the FDA pre-approval inspection conducted during the review
of the Northera NDA. Further, we have submitted all source documentation from all patients at the site and engaged
independent, third-party quality experts to confirm the validity of data from the site. Notwithstanding this information, the
FDA has and continues to maintain that the concentration and pattern of positive results at this site preclude    Study 301
meeting the criteria for a single-study approval, on which our NDA had been prepared.



Although modified by subsequent guidance, in June 2012, the
FDA advised that, based on the theoretical potential for un-blinding, Study 306B was unlikely to provide sufficient confirmatory
evidence to support a Northera NDA. Soon after receipt of the written response from the FDA, we stopped enrolling patients in
our Study 306B. Total enrollment was completed with 174 patients randomized, representing the single largest placebo-controlled
study ever conducted in Neurogenic OH. In addition, we modified the primary endpoint of Study 306B to the mean change in OHSA
item #1 score (dizziness, lightheadedness, feeling faint or “feeling like you might black out”) at visit 4 (one-week
post titration). The rate of patient reported falls was a secondary efficacy endpoint of the study. In December 2012, we announced
that preliminary results of Study 306B showed that the primary endpoint of the study had been met. The results showed that treatment
with Northera provided clinically meaningful and statistically significant improvements compared to placebo in dizziness/lightheadedness
at week 1 (1.0 unit change; p=0.018), the primary endpoint. In addition, compared to placebo, a statistically significantly
greater number of patients were observed to experience 2, 3 or 4 unit improvements at week 1 compared to baseline (all p-values
< 0.05). Study results also demonstrated a statistically significant increase in standing systolic blood pressure (SBP)
at week 1 (5.6 mmHg; p=0.032), an important secondary endpoint of the study. At time points beyond week 1, dizziness/lightheadedness
and standing blood pressure predominantly favored Northera-treated patients, although the results were not statistically significant.



5







Treatment with Northera also resulted in a reduction in the
rate of patient falls over the course of Study 306B, although these results were not statistically significant.  Patients
receiving placebo experienced a rate of falls per patient per week of 2.0 vs. 0.4 for those on Northera, an 80% reduction. Because
several patients on placebo experienced a very large number of falls, we performed multiple sensitivity analyses on this outcome. These
analyses showed that the beneficial effect of Northera on falls was evident even if the top 2, 5 or 10 fallers from each treatment
group were removed (34%, 36% and 29% reduction, respectively, p=NS). Importantly, the falls data were supported by additional
safety data showing that 34% fewer patients receiving Northera experienced fall-related injuries (e.g., contusions, lacerations,
fractures) than patients receiving placebo (placebo=25.6% vs. Northera=16.9%, p=NS). Both the reduction in falls and fall-related
injuries associated with Northera are consistent with results observed in Study 306A. Preliminary safety data showed that Northera
was well tolerated at all dosages tested and, as in prior studies, the incidence of supine hypertension was low.



Following an initial discussion in 2006, we have conducted
only limited discussions of the specifics of our clinical program for Northera with the EMA and the regulatory agencies of
several European Union member countries and it remains unclear  if our current program will be acceptable for marketing
approval in the European Union or if we may be required to conduct additional clinical trials.



Intradialytic Hypotension



IDH is another indication for which DSP conducted extensive
clinical evaluation. Pivotal clinical studies conducted by DSP have demonstrated the efficacy of droxidopa in the prevention of
vertigo, dizziness and weakness associated with hypotension in hemodialysis patients. Subsequently, in 2000, after showing benefit
in clinical trials, DSP received expanded marketing approval in Japan for this indication.



Intradialytic hypotension is the most common adverse event
during routine hemodialysis. IDH is often defined as a decrease in systolic blood pressure by ≥ 20 mm Hg or a decrease in mean
arterial pressure by 10 mm Hg. IDH has been reported in 15-25% of all hemodialysis patients, with elderly patients reporting an
even higher incidence. Many adverse hemodialysis events, including headaches, lightheadedness, nausea, cramps, and seizures, are
associated with IDH. These complications can routinely interrupt dialysis sessions, resulting in insufficient uremia toxin removal
and necessitating repetition of the procedure. Interruptions due to IDH increase the costs of both the dialysis treatment sessions
and the long-term care of less healthy hemodialysis patients.



In March 2009, we reported results from a double-blind, placebo
controlled trial comparing 400mg and 600mg of droxidopa to placebo. Following a two-week run-in period to establish a baseline
for all measurements, patients in this three-arm study received a single oral dose of droxidopa or placebo one hour prior to each
dialysis treatment over a four-week period. In order to determine useful clinical endpoints for a Phase III program, the trial
evaluated the efficacy of droxidopa using multiple clinically relevant measures, including: the change from baseline in average
mean arterial blood pressure during dialysis; the change from baseline in average mean nadir (lowest) blood pressure during dialysis;
the number of treatment interventions, including early termination, required during dialysis sessions; and the change from baseline
in mean postdialytic blood pressure during the final two weeks of the study period. The study recruited 85 patients at 15 sites
in the United States. Droxidopa demonstrated a dose dependent, statistically significant benefit across multiple, clinically relevant
assessment criteria for IDH. While the study did not achieve an improvement in mean arterial blood pressure during dialysis, the
prospective primary endpoint for the study, droxidopa demonstrated a significant benefit in limiting the severity of the drop
(nadir) in blood pressure during treatment. The data also showed that droxidopa was well tolerated by patients with the most common
treatment-related side effect reported being headache (3%). Results from this study might be used to determine clinical endpoints
for a potential future Phase III program that might allow us to file for the first marketing approval of a therapeutic agent for
IDH in the United States.



Fibromyalgia



Fibromyalgia is a polysymptomatic syndrome characterized by
chronic, widespread musculoskeletal pain, multiple tender points, abnormal pain sensitivity, and is often accompanied by severe
fatigue, insomnia and mood symptoms. According to the American College of Rheumatology, fibromyalgia is the second most commonly
diagnosed condition in rheumatology clinics in the United States after osteoarthritis and is estimated to affect over six million
Americans. While the precise etiology of fibromyalgia remains unknown, current research includes the role of norepinephrine reuptake
and availability in the central nervous system. Norepinephrine, a widely used neurotransmitter in the central and peripheral nervous
systems, has long been linked to both chronic pain and depression. While norepinephrine, as a catecholamine, does not penetrate
the blood-brain barrier, droxidopa, as a neutral amino acid, is able to do so thus providing both a peripheral and central effect
on circulating norepinephrine levels. In prior studies conducted by DSP, droxidopa has shown statistically significant dose-dependent
analgesia in chronic pain.



6







In December 2011, we reported results of a Phase II dose-finding
study designed to evaluate the safety and determine the potential therapeutic dose range of droxidopa, alone or in combination
with carbidopa, which might be effective for the treatment of fibromyalgia. Topline results of the study indicate a dose response
with the highest dose of droxidopa, 600 mg three times daily, or TID, demonstrating a 6.2-point average improvement from a baseline
score of 23.00 on the Short Form McGill Questionnaire (SF-MPQ) at the end of the nine-week treatment period, the study’s
primary endpoint. This reflects a 3.2 unit improvement over placebo on the SF-MPQ total pain score. Although the study was not
designed to demonstrate statistical significance given the limited number of patients per arm, results of the study show a mean
change in pain as measured by the visual analog scale (VAS) of -1.64 for patients treated with droxidopa monotherapy compared
to a mean change of -0.90 for placebo. Assessment using the Fibromyalgia Index Questionnaire (FIQ) showed patients treated with
droxidopa monotherapy demonstrated a mean change from baseline of -9.72 compared to -4.74 reported by patients in the placebo
arm. Interestingly, administration of droxidopa as a monotherapy proved more effective than droxidopa/carbidopa combination therapy
in this study. The Phase II trial, conducted in the U.K., was a multi-center, randomized, double-blind, placebo-controlled, dose
response, factorial parallel group study evaluating 120 patients equally randomized to receive droxidopa monotherapy, carbidopa
monotherapy, droxidopa/carbidopa combination therapy or placebo over a 9-week treatment period. Secondary outcomes of the study
include Fibromyalgia Index Questionnaire (FIQ), Patient Global Impression of Change (PGI-C), Multidimensional Fatigue Inventory
(MFI), and Hamilton Anxiety Depression survey (HAMA).



Additional Potential Indications for Droxidopa



In addition to the indications for which we have established
active clinical programs, we believe there are a significant number of other therapeutic indications in which norepinephrine function
plays a key role and for which droxidopa may provide clinical benefit. To facilitate research in additional indications and maximize
the long-term development potential, we have initiated an extra-mural development program that enables independent investigators
to conduct clinical trials in their respective fields of expertise. Specifically, we have been exploring Phase II clinical studies,
under investigator-sponsored investigational new drug applications, or INDs, intended to evaluate the safety and efficacy of droxidopa
in ADHD and hypotensive patients with spinal cord injury, or SCI. For studies conducted under investigator-sponsored INDs, we
have limited control over the timing for initiating or completing these studies and, therefore, cannot predict with any certainty
when data from these programs will be available.



In July 2011, we announced positive top-line results of an
investigator-led Phase II clinical study of droxidopa in combination with carbidopa in 20 adults with ADHD indicating that droxidopa
dramatically improved patients’ mean score on the adult ADHD Investigator Symptom Rating Scale, or AISRS. The AISRS is a
standardized, validated rating scale for assessing symptoms of adult ADHD and for measuring response to treatment. Upon enrollment,
patients in the study had a mean AISRS score of 34. After three weeks of open-label droxidopa monotherapy (titration from 200mg-600mg
TID), the mean AISRS score decreased by approximately 47% to 19 (p<0.0001). The reduction in AISRS score was maintained with
the addition of carbidopa (25mg or 50mg) for another three weeks.



In September 2012, results from an investigator-led, Phase
II study to evaluate droxidopa for the treatment of orthostatic hypotension resulting from SCI,
preliminary data suggest that low to moderate doses of droxidopa do not worsen supine increases in blood pressure in persons with
SCI.  Although droxidopa increased seated blood pressure in a dose-dependent manner, subjects remained relatively hypotensive. 
Additional studies would be necessary to determine the effective dose of droxidopa that normalizes blood pressure in this population.



We plan to continue working with key opinion leaders to identify
and evaluate additional potential indications for droxidopa and may provide droxidopa for future studies when deemed appropriate
and as funding and availability of drug substance permits.



7







Droxidopa Competition



Neurogenic Orthostatic Hypotension



Midodrine(ProAmatine®)



Midodrine is currently the only FDA-approved therapeutic for
the treatment of orthostatic hypotension. Midodrine’s product label contains a black box warning for the side effect of
supine hypertension, along with the statement that midodrine has not shown benefit to patients’ Activities of Daily Living,
or symptomatic/functional benefit. In August 2010, the FDA proposed removing
midodrine from the market because required post-approval studies to verify the clinical benefit of the drug have not been satisfactorily
completed by Shire plc, the holder of the NDA for ProAmatineTM (midodrine HCL).In January
2011, the FDA announced the opening of a public docket (FDA-2010-N-0475) to provide a forum to facilitate communication regarding
the conduct of clinical trials needed to support continued marketing authorization for midodrine.



In December 2011, Shire reached an agreement with the
FDA and in February 2012, the FDA’s Center for Drug Evaluation, or CDER, also agreed to allow Shire to conduct
two additional clinical trials to demonstrate the clinical benefit of ProAmatine by the end of 2014. While these trials
are ongoing, the proposal to withdraw midodrine from the market has been placed on hold. Should the FDA determine that Shire
has failed to adhere to the terms or timeframes specified in this agreement, or the agreed upon trials fail to verify
clinical benefit, Shire has agreed to have the FDA make decisions on midodrine without a public hearing, including the
potential for withdrawing the marketing approval for midodrine.



As the only approved compound for orthostatic hypotension in
the U.S, midodrine’s removal could facilitate higher sales and/or more rapid acceptance of Northera in this indication.
However, the FDA has never removed a drug under similar circumstances and we can provide no assurance that they will do so in
the case of midodrine.



Other than the increase in blood pressure caused by vasoconstriction,
additional midodrine side effects include paresthesia (tingling), piloerection (goosebumps), dysuria (painful urination), and
pruritus (itching). The most recently available information shows annual sales (branded and generic) in 2011 of approximately
$61 million in the United States. In addition to Shire’s ProAmatine brand, Mylan Pharmaceuticals, Impax Laboratories (Global
Pharmaceuticals), Sandoz, Apotex and Upsher-Smith are generic manufacturers of the compound.



Fludrocortisone(Florinef®)



Fludrocortisone is also widely used in the treatment of orthostatic
hypotension although this specific indication has not been approved by the FDA. Fludrocortisone is a synthetic adrenocortical
steroid possessing very potent mineralocorticoid properties and high glucocorticoid activity. Fludrocortisone, in small oral doses
(0.1mg.) produces marked sodium retention and increased urinary potassium excretion leading to enhanced plasma volume and a rise
in blood pressure. Side effects include hypertension, water and sodium retention and potassium, or K+, loss. Fludrocortisone is
not FDA-approved for Neurogenic OH.



Intradialytic Hypotension



There is currently no FDA-approved drug for treatment or prevention
of intradialytic hypotension. Common methods for treating IDH include the manual adjustment of ultrafiltration rate, a cumbersome
procedure in daily practice. Some dialysis patients are known to take midodrine prophylactically, either before or during dialysis,
to prevent intradialytic hypotension. However, midodrine is known to be eliminated through the kidneys and is removed by dialysis,
thereby limiting its widespread use in this indication.



Fibromyalgia



While doctors have used antidepressants and pain drugs for
years, in June 2007, the FDA granted its first approval for the treatment of fibromyalgia to Pfizer’s Lyrica®,
which was already used to treat epilepsy and neuropathic pain. U.S. sales of Lyrica® in 2012 totaled $1.9 billion.
Eli Lilly received approval in 2008 to market Cymbalta®, a selective serotonin and norepinephrine reuptake inhibitor,
to treat fibromyalgia and generated sales in all indications of $4.5 billion in 2012. Cypress Biosciences, with their partner
Forest Laboratories, received FDA approval in early 2009 for Savella® for the treatment of fibromyalgia. Savella®is a norepinephrine serotonin reuptake inhibitor that increases the level of norepinephrine more than it does serotonin
and had U.S. sales of $103 million in fiscal 2012.



8







Northera Marketing



We currently estimate that nearly 400,000 patients suffer
from chronic, symptomatic Neurogenic OH in the United States and the European Union combined. This condition is commonly
associated with PD, PAF and MSA, the latter encompassing disorders previously known as striatonigral degeneration,
olivoponto-cerebellar atrophy and the Shy-Drager syndrome. In addition to the broader symptoms and impact on activities of
daily living, Neurogenic OH significantly increases the risk of falls in patients with PD and is believed to be responsible
for significant healthcare costs due to the high incidence of falls-related injuries in this patient population, particularly
in elderly patients. According to the Centers for Disease Control and Prevention, the cost of medical care for falls-related
injuries was estimated to be approximately $19 billion in 2000 and is estimated to grow to $55 billion by 2020. The National
Center for Injury Prevention and Control estimates this cost to be between $82 billion and $240 billion with over 500,000
hospitalizations in 2040. Preliminary data from our studies suggests that the use of Northera by patients with Neurogenic OH
associated with PD results in a reduction in falls in these patients and provides a rationale for continued interest in
evaluating the impact of Northera on falls. Reducing serious falls by 30% in this population, by our estimate, could result in
a potential annual savings of approximately $5 billion in falls-related costs, including the costs of extended care
in skilled nursing facilities.



Metabolically
Inert Antifolates



Product Overview



Our portfolio of novel antifolate compounds was originally
developed by Dr. M. Gopal Nair and licensed to us in 2004. A library of orally available and metabolically inert antifolate compounds
with potent autoimmune, anti-inflammatory and anti-tumor properties, these compounds are engineered to treat a broad range of
immunological disorders with fewer harmful and unpleasant side effects than those typically associated with classical antifolates
such as methotrexate, or MTX, currently the leading antifolate treatment and standard of care for a broad range of abnormal cell
proliferation diseases.

Drug candidates from this portfolio, including both clinical
candidates CH-1504 and CH-4051, inhibit dihydrofolate reductase, an enzyme required for cell proliferation, but, due to the lack
of metabolism, are devoid of the metabolites believed to play a significant role in the liver and kidney toxicities associated
with long-term use of MTX and show a clinically relevant decrease in toxicity compared to MTX.



We believe these unique antifolates might have clinical advantages
over MTX as they might have less toxicity and increased tolerability while maintaining equal or potentially greater efficacy.
Potential advantages over existing therapies, supported by our preclinical and clinical work to date, include:



| | · | faster
                                                                                                             onset of action;
| | - | ------------------------------------------------------------------------------------------------------------------------------------

| | · | better
                                                                                                             tolerability; and
| | - | -------------------------------------------------------------------------------------------------------------------------------------

| | · | superior
                                                                                                             toxicity profile.
| | - | ---------------------------------------------------------------------------------------------------------------------------------------



Diseases that may potentially be treated with metabolically
inert antifolates include rheumatoid arthritis, psoriasis, Crohn’s disease, uveitis, ankylosing spondylitis, inflammatory
bowel disease, cancer and other immunological disorders.



Clinical Development



Our portfolio of drug candidates includes multiple molecules
for the treatment of various autoimmune/inflammatory diseases. The most advanced platform is a portfolio of metabolically-inert
antifolate molecules engineered to have potent anti-inflammatory and anti-tumor activity to treat a range of immunological disorders,
including two clinical stage product candidates designated as CH-1504 and CH-4051. CH-1504 has completed Phase II trials in rheumatoid
arthritis. While we do not intend to conduct additional trials or make further investments in the development of CH-1504, clinical
work related to this compound might provide meaningful informative data supporting the development of additional compounds in
this portfolio. Based on preclinical and clinical findings to date, we have more recently focused our clinical resources on the
development of CH-4051, the second clinical stage compound in this portfolio and the more potent L-enantiomer of CH-1504. CH-4051
has been studied in rheumatoid arthritis as its lead indication, having completed a Phase I trial in April 2009 and a Phase II
trial for the treatment of rheumatoid arthritis in May 2012.



9







Rheumatoid arthritis is a chronic inflammatory disease that
leads to pain, stiffness, swelling and limitation in the motion and function of multiple joints. If left untreated, rheumatoid
arthritis can produce serious destruction of joints that frequently leads to permanent disability. Though the joints are the principal
body part affected by rheumatoid arthritis, inflammation can develop in organs and other body parts as well. The disease currently
affects over two million Americans, almost 1% of the population, and is two to three times more prevalent in women. Onset can
occur at any point in life with most patients developing the disease between the ages of 35 and 50.



Given the variation in the metabolism of MTX, we believe that
our novel antifolates might have significant clinical advantages over MTX in rheumatoid arthritis patients due to metabolic stability.
Because of this stability, it can be hypothesized that in those patients who fail to achieve a sufficient therapeutic response
to MTX as a result of either a slower or more rapid metabolism of MTX, a non-metabolized antifolate might be clinically efficacious
since it is not deactivated by these enzymatic processes.



CH-4051



In parallel to our clinical development of CH-1504, we continued
additional preclinical evaluation, including formulation work on the enantiomers of CH-1504. After conducting studies to determine
the relative potency of the L- and D-isomers, we found that the L-isomer, now identified as CH-4051, was the more potent of the
two thus prompting additional preclinical evaluation of CH-4051.



In April 2008, we reported findings from a 17-day preclinical
study of CH-4051 designed to test the efficacy of CH-4051 in a rat collagen-induced arthritis, or CIA, model. The results reveal
efficacy in delaying the onset of the disease, significantly decreasing the severity and, at certain doses, completely blocking
all development of rheumatoid arthritis. The most significant finding from this study was that once daily dosing of 10mg/kg of
CH-4051 administered from day 0 completely prevented the onset of arthritis. Similarly, twice daily 5mg/kg doses of CH-4051 reduced
the severity of disease in all animals and prevented disease onset in some. Both the once-daily dose of 10mg/kg and the twice-daily
dose of 5mg/kg dose of CH-4051 demonstrated better prevention of disease than 0.25mg/kg of methotrexate (a known maximally tolerated
dose, or MTD, in this model) administered every three days.



In April 2009, we announced positive findings from our Phase
I study of CH-4051. Data from this single and multiple ascending dose study demonstrated that CH-4051 is safe and well tolerated
up to a MTD of 7.5mg. This randomized, double-blind, placebo-controlled study was conducted at Kendle International's Clinical
Pharmacology Unit in the Netherlands. The primary objective of the study was to evaluate the safety, tolerability and pharmacokinetics
of single and multiple ascending doses of CH-4051 in healthy male volunteers and to determine the MTD.



The single ascending dose, or SAD, phase of the study evaluated
5mg, 10mg, 20mg and 40mg doses of CH-4051. Each group contained 6 volunteers randomized 5:1 to receive either CH-4051 or placebo.
In this escalating dose study, each cohort of subjects received a higher dose of the drug than the preceding cohort.



Based on the findings from the SAD study, we selected 5mg,
7.5mg, 10mg and 20mg of CH-4051 for evaluation in a multiple ascending dose, or MAD, study with the objective of exploring a wide
range of doses, including and exceeding those believed to be therapeutically relevant. In the MAD study, 32 subjects in 4 cohorts
of 8 volunteers were randomized 6:2 to receive repeat daily oral doses of CH-4051 or placebo for 14 consecutive days.



Results demonstrated that CH-4051 was well tolerated at doses
up to and including 7.5mg, a dose range likely to be effective for multiple autoimmune disorders. The 5mg dose was as well tolerated
as placebo. High doses of CH-4051 demonstrated mostly mild toxicities, with the 10mg and 20mg doses groups reporting both gastrointestinal
side-effects and reversible liver enzyme elevations. No serious adverse events occurred during the study. The dose range determined
to be safe and well tolerated in this study is substantially higher than the 0.25mg to 1mg dose range of the less potent CH-1504
that demonstrated comparable efficacy and improved safety and tolerability to methotrexate in the recent Phase II rheumatoid arthritis
trial.



10







Based on these findings, in September 2010 we initiated a double-blind,
multiple-arm randomized Phase II study, with a primary efficacy endpoint of the American College of Rheumatology, or ACR, hybrid
score that combines a continuous scale of percentage improvement with the well-known ACR20/50/70.



In November 2011, we announced results from an interim analysis
of unblinded efficacy data from the lower two of three doses of CH-4051 and half of the patients enrolled into the MTX control
arm in in this exploratory Phase II trial. Preliminary results from the unblinded interim suggest a dose-dependent therapeutic
response in which patients treated with the mid-range, or 1.0 mg daily oral dose, of CH-4051 experienced similar efficacy to patients
treated with a standard 20.0 mg weekly dose of MTX. This response suggests that patients currently receiving triple the dose,
or 3.0 mg, of CH-4051 in the ongoing study may experience greater therapeutic benefits than patients treated with MTX.



In May 2012, we announced the top-line results of our completed
multinational, 12-week, double-blind Phase II trial of CH-4051 in patients with rheumatoid arthritis, designed to compare the
efficacy and tolerability of CH-4051 against methotrexate, currently the leading antifolate treatment and standard of care for
a broad range of abnormal cell proliferation diseases. This Phase II trial was conducted in 244 patients with rheumatoid arthritis
who experience an inadequate response to methotrexate treatment. Results of this trial indicated that CH-4051 did not demonstrate
superior efficacy to methotrexate in the dose range evaluated. CH-4051 was found to be safe and well-tolerated in the study, with
no dose-limiting toxicities or clear differences in the overall adverse event rate between methotrexate and the CH-4051 treatment
groups.



While management believes that higher doses of CH-4051 might
provide enhanced therapeutic benefit in rheumatoid arthritis and that CH-4051 could be developed for other anti-inflammatory and
autoimmune indications, we determined that current resources would be better allocated toward the planned completion of the Northera
development program in Neurogenic OH. As such, there are no immediate plans to continue the development of CH-4051 although we
do continue to discuss potential out-licensing opportunities for this portfolio of molecules.



CH-1504



In June 2005, we commenced Phase I single and multiple dose
escalation clinical trials of CH-1504 in healthy volunteers. These trials were conducted at Guy’s Hospital in London under
the Clinical Trial Authorization, issued by the Medicines and Healthcare Products Regulatory Agency, the United Kingdom’s
health authority. The in vivo portion and preliminary analysis of these trials were completed in December 2005.



Continuing evaluation of these results in light of additional
preclinical data suggested that the bioavailability of CH-1504 was low and had significant pharmacokinetic variability. Following
a review of available data suggesting the bioavailability of our free-acid formulation of CH-1504 could be improved, we reformulated
CH-1504 utilizing a disodium-salt formulation. Subsequent human bioequivalence studies showed 1mg of the new formulation to be
comparable to 15mg of the original free-acid formulation and demonstrated an 11.4-fold improvement in relative bioavailability,
as measured by area under the curve with an 8.9-fold increase in peak plasma levels (Cmax).



In March 2009, we announced the results of a Phase II proof
of concept study for CH-1504 in rheumatoid arthritis.  The study was a multi-national, 12-week double-blind and randomized
study in Russia, Ukraine, Poland and Canada with 200 MTX-naive rheumatoid arthritis patients.  The 4-arm trial included a
0.25mg, 0.5mg or 1mg daily dose of CH-1504 versus a 20 mg weekly dose of MTX.  Results showed comparable ACR 20/50/70 response
rates among patients treated with CH-1504 compared to methotrexate. In addition, the efficacy of CH-1504 was associated with improved
tolerability and reduced liver enzyme elevations compared with methotrexate.



Because Phase I data suggested CH-4051 retains the superior
safety and tolerability profile of CH-1504 while preclinical data suggested both an enhanced potency compared to CH-1504 and significant
superiority to methotrexate, we plan no additional trials of CH-1504.



11







Other Potential Indications for our Antifolate Portfolio



When available resources allow, we might continue our evaluation
of our antifolate portfolio in other indications. Additional potential indications for our antifolates include psoriasis, Crohn’s
disease, uveitis, ankylosing spondylitis, inflammatory bowel disease, certain cancers and other immunological disorders. If and
as our antifolates advance in rheumatoid arthritis studies, we could begin to focus on the timing of clinical programs for our
antifolate compounds in these additional indications.



Antifolate Competition



There are many different drugs that are used to treat rheumatoid
arthritis, including hormones, small molecules and biologics, which are manufactured using recombinant technology. The normal
course of therapy for rheumatoid arthritis begins with analgesics, such as aspirin, and non-steroidal anti-inflammatory agents,
followed by disease modifying anti-rheumatic drugs, or DMARDs, including low dose steroids, MTX, leflunomide and biologics, and,
finally, reconstructive joint surgery for patients failing all therapies. DMARDs are the only drugs that have been shown to alter
the course of the disease.



Currently Available DMARDss. MTX, a classical antifolate,
was originally used as a chemotherapy drug to treat certain kinds of cancer, but was also found to be beneficial in treating inflammatory
arthritis and psoriasis. MTX is generic and marketed in both injectable and oral formulations by multiple companies including
Barr Laboratories, Boehringer Ingelheim Pharma, Mayne Pharma and Mylan Laboratories. Traditional oral DMARDs include MTX, leflunomide,
auranofin, sulfaszlazine, cyclosporine, hydroxychloroquine, azathioprine and penicillamine. In November 2012, the FDA approved
the newest oral small molecule DMARD, Pfizer’s JAK3 inhibitor (Xeljanz, formerly tasocitinib) for the treatment of rheumatoid
arthritis. We believe that with significant ACR scores and good tolerability in addition to the benefit of oral delivery, Xeljanz
may be a favorable alternative to the currently approved biological agents.



Currently Available Biologics. Although there have been
positive results for biologics, we believe physicians are likely to reserve anti-tumor necrosis factor, or anti-TNF, and other
biologic therapies for patients who have failed or had a limited response to initial MTX monotherapy. Despite increased aggressiveness
of treating physicians and easier reimbursement, we believe front line use with biologics either in monotherapy or in combination
with MTX is unlikely to occur due to their high costs and side effect profile. Humira®, Enbrel®and Remicade® are TNF blockers that have been approved by the FDA
and are the top selling biologics for rheumatoid arthritis with 2012 U.S. sales of $4.3 billion, $4 billion and $3.7 billion,
respectively. These three TNF blockers are administered to patients by injection and can be used alone or in combination with
other DMARDs, such as MTX, or NSAIDs such as aspirin or ibuprofen. Other biologics available for the treatment of rheumatoid arthritis
are Simponi®, Rituxan®, Orencia®, Cimzia®, Actemra®,
and Kineret®.



DMARDs and Biologics in Development.There are numerous small molecule oral DMARDs and biologics in various stages of clinical development for rheumatoid arthritis.
The most advanced small molecule DMARD is Rigel Pharmaceuticals’ R788 (fostamatinib disodium), licensed by AstraZeneca in
February 2010. Fostamatinib is currently in Phase III clinical trials in rheumatoid arthritis and is expected to report data from
those trials in early 2013. An oral syk kinase inhibitor, fostamatinib demonstrated statistically significant results in treating
rheumatoid arthritis patients in Phase II clinical trials. However, we anticipate that, like most biologics, this and other small
molecule oral DMARDs would work best in combination with MTX or similar antifolates and should not significantly impact the opportunity
available to our antifolate portfolio.



Antifolate Marketing



Given the size of the rheumatoid arthritis market, the vast
sales forces required to compete in this market, and the necessary infrastructure required, our marketing strategy for our antifolates
would include contracting with or licensing to third parties. It is possible that we might directly commercialize or co-promote
our antifolate compounds in the smaller therapeutic indications such as psoriasis or irritable bowel disease. Out-licensing arrangements
might be negotiated and entered into prior to one or more of our antifolate drug candidates being approved for marketing.



12







I-3D PORTFOLIO



In May 2006, we signed an agreement with Active Biotech AB
for the co-development and commercialization of the I-3D portfolio, a group of orally active compounds that inhibit the enzyme
DHODH for the treatment of autoimmune diseases and transplant rejection. At the time of the agreement, Active Biotech had already
isolated more than 15 compounds and conducted extensive preclinical modeling resulting in the identification of two potential
lead compounds.



Having previously demonstrated proof of concept in both rheumatoid
arthritis and transplant rejection in animal models, the joint development committee selected AB-224050 as the first I-3D compound
to undergo IND-enabling toxicology studies during the third quarter of 2006. As part of the ongoing evaluation and preparation
for Phase I trials, the joint development committee initiated a Phase 0 (micro-dosing) study to evaluate the half-life of AB-224050
in humans in the first quarter of 2007.   Based on the results of the micro-dosing study and other ongoing preclinical
activity, it was determined that, while demonstrating a significantly shorter half-life than Arava®, AB-224050 would require
additional work prior to the commencement of Phase I clinical trials.  In 2007, the joint development committee continued
preclinical optimization of AB-224050 and conducted further comparisons of AB-224050 versus other compounds in the I-3D.



In April 2008, following a decision to focus its resources
on its immunomodulatory compounds, Active Biotech AB discontinued its participation in the I-3D co-development program and granted
us exclusive global rights to the portfolio in exchange for royalties on future sales. As a result of our limited funding and
strategic development efforts associated with the development of droxidopa and our antifolate drug candidates, we currently do
not have any active clinical or preclinical programs associated with compounds from this portfolio.



In addition to therapeutic applications in rheumatoid arthritis,
compounds from the I-3D portfolio are believed to have broad clinical application in immune-mediated inflammatory disorders including
transplant rejection, psoriasis and systemic lupus erythematosus.



Government Regulation



The FDA and foreign regulatory agencies regulate many aspects
of product development and marketing of our product candidates including research, development, manufacture, labeling, promotion,
advertising, distribution, and marketing. Meeting the various U.S. and international regulatory requirements often takes several
years, and the actual time required can vary substantially based upon the type, complexity and novelty of the pharmaceutical product
and the therapeutic indication. Furthermore, meeting the regulatory requirements as well as maintaining compliance often necessitates
implementing costly procedures. Failure to comply with the applicable requirements mandated by the FDA and other regulatory agencies
can result in administrative or judicial sanctions and/or fines. In the United States, such sanctions may include the FDA’s
refusal to approve pending NDAs, warning letters, product recalls, product seizures, total or partial suspension of production
or distribution, injunctions and/or criminal prosecution.



Success in preclinical or early-stage clinical trials does
not ensure success in late-stage clinical trials. Data obtained from preclinical and early stage clinical activities are not always
conclusive and are susceptible to varying interpretations that could negatively impact our trials and delay, limit or prevent
regulatory approval. In addition, we cannot be certain that the FDA or any other international regulatory agency will grant approval
for any of our products under development on a timely basis, if at all. Delays in obtaining, or failures to obtain, regulatory
approvals would have a material adverse effect on our business. Even if a product receives regulatory approval, the approval might
be significantly limited to specific indications or uses. After regulatory approval is obtained and the product becomes available
on the market, the later discovery, over time, of previously unknown problems with a product might result in restrictions on the
product or even complete withdrawal of the product from the market.



Drug Approval Process in the United States



In the United States, the FDA regulates drugs
under the Federal Food, Drug, and Cosmetic Act, or FDCA, and those regulations are published in the Federal Register. None of
our drugs may be marketed in the United States until the drug has received FDA approval. The process required before a drug can
be marketed in the United States includes:



| | · | preclinical
                                                                                                             laboratory tests,
                                                                                                             animal pharmacology
                                                                                                             and toxicology studies,
                                                                                                             and formulation studies;
| | - | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



13







| | · | submission
                                                                                                             to the FDA of an
                                                                                                             investigational new
                                                                                                             drug application,
                                                                                                             or IND, for human
                                                                                                             clinical testing,
                                                                                                             which must be cleared
                                                                                                             by the FDA before
                                                                                                             human clinical trials
                                                                                                             can begin in the
                                                                                                             United States;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | adequate
                                                                                                             and well-controlled
                                                                                                             human clinical trials
                                                                                                             to establish the
                                                                                                             safety and efficacy
                                                                                                             of the drug for each
                                                                                                             indication;
| | - | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | submission
                                                                                                             to the FDA of a new
                                                                                                             drug application,
                                                                                                             or NDA;
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | satisfactory
                                                                                                             completion of any
                                                                                                             FDA inspections of
                                                                                                             the manufacturing
                                                                                                             facility or facilities
                                                                                                             at which the drug
                                                                                                             is produced to assess
                                                                                                             compliance with current
                                                                                                             good manufacturing
                                                                                                             practices, or cGMPs;
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | FDA review and
                                                                                                             approval of the NDA;
                                                                                                             and
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | the completion
                                                                                                             of any contingent
                                                                                                             requirements of the
                                                                                                             FDA as a condition
                                                                                                             to maintaining marketing
                                                                                                             approval once granted.
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Preclinical tests include laboratory tests and animal studies.
The conduct of the preclinical tests as well as the formulation of the compounds must comply with FDA regulations. The preclinical
test data, together with manufacturing information and analytical data of product chemistry are submitted to the FDA as part of
an IND, which must become effective before human clinical trials can begin. Human clinical trials submitted to the FDA as part
of an IND will automatically become effective 30 days after receipt by the FDA, unless, within those 30 days, the FDA raises concerns
or questions regarding the clinical trials, or places a clinical hold on the IND. In such a case, the IND sponsor and the FDA
must resolve any outstanding FDA concerns or questions before clinical trials can proceed. We cannot be certain that submission
of an IND will result in clearance by the FDA to allow clinical trials to begin.



Clinical trials involve the administration of the investigational
drug to human subjects under the supervision of qualified clinical investigators. Clinical trials are conducted under protocols
detailing the objectives of the study, the parameters to be used in monitoring safety, and the effectiveness criteria to be evaluated.
Each clinical trial protocol must be submitted to the FDA as part of an IND.



Clinical trials typically are conducted in three sequential
phases, but the phases might overlap. The study protocol and informed consent information for study subjects in clinical trials
must also be approved by an Institutional Review Board for each institution where the trials will be conducted. Study subjects
must sign an informed consent form before participating in a clinical trial. The normal clinical trial phases are:



| | · | Phase
                                                                                                               I usually involves
                                                                                                               the initial introduction
                                                                                                               of the investigational
                                                                                                               drug into healthy
                                                                                                               volunteers to evaluate
                                                                                                               its short-term
                                                                                                               safety, dosage
                                                                                                               tolerance, metabolism,
                                                                                                               pharmacokinetics
                                                                                                               and pharmacologic
                                                                                                               actions, and, if
                                                                                                               possible, to gain
                                                                                                               an early indication
                                                                                                               of its effectiveness.
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | Phase II usually
                                                                                                               involves trials
                                                                                                               in a small patient
                                                                                                               population to evaluate
                                                                                                               dosage tolerance
                                                                                                               and appropriate
                                                                                                               dosage, identify
                                                                                                               possible adverse
                                                                                                               effects and safety
                                                                                                               risks, and evaluate
                                                                                                               preliminarily the
                                                                                                               efficacy of the
                                                                                                               drug for specific
                                                                                                               indications.
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | Phase
                                                                                                               III trials usually
                                                                                                               involve further
                                                                                                               evaluation of clinical
                                                                                                               safety and efficacy
                                                                                                               by using the drug
                                                                                                               in its final form
                                                                                                               in a larger patient
                                                                                                               population.
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



There can be no assurance that Phase I, Phase II, or Phase
III testing will be completed successfully within any specified period of time, if at all. Furthermore, clinical trials might
be suspended by us or the FDA at any time on various grounds, including a finding that the subjects or patients are being exposed
to an unacceptable health risk.



Once the required clinical testing is successfully completed,
the results of the preclinical studies and of the clinical studies, as well as information on the manufacture and composition
of the drug, are submitted to the FDA in an NDA. If the FDA grants NDA approval, the product can then be marketed for one or more
approved indications. On the other hand, if the FDA reviews the application and deems it to be inadequate to support the NDA approval,
and hence, marketing approval, an approval might not be granted on a timely basis, if at all. The FDA might also refer the application
to the appropriate advisory committee, typically a panel of clinicians and scientists, for review, evaluation and a recommendation
as to whether the application should be approved. The FDA is not bound by the recommendations of the advisory committee.



The overall drug development process, including preclinical
testing and clinical trials through to marketing approval, requires substantial time, effort and financial resources.



14







The FDA has various programs, including fast track, priority
review, and accelerated approval, that are intended to expedite or simplify the process for reviewing drugs, and/or provide for
approval on the basis of surrogate endpoints. Generally, drugs that might be eligible for one or more of these programs are those
for serious or life-threatening conditions, those with the potential to address unmet medical needs, and those that provide meaningful
benefit over existing treatments. While Northera has qualified as Fast Track , we cannot ensure that any of our other drugs will
qualify for any of these programs, or, to the extent that a drug does qualify, that the review time will be reduced.



Section 505b2 of the FDCA allows the FDA to approve a follow-on
drug on the basis of data in the scientific literature or data used by the FDA in the approval of other drugs. This procedure
potentially makes it easier for drug manufacturers to obtain rapid approval of new forms of drugs based on proprietary data of
the original drug manufacturer.



Before approving an NDA, the FDA usually will inspect the facility
or the facilities at which the drug is manufactured, and may not approve the product unless the manufacturing site is good manufacturing
practices, or cGMP, compliant. Similarly, the FDA may inspect clinical sites and analytical laboratories to determine compliance
with good clinical and laboratory practices.



If the FDA evaluates the NDA, the FDA might issue an approval
letter, or in some cases, an approvable letter followed by an approval letter. Both letters usually contain a number of conditions
that must be met in order to secure final approval of the NDA. When and if those conditions have been met to the FDA’s satisfaction,
the FDA will issue a final approval letter. The final approval letter authorizes commercial marketing of the drug for specific
indications. As a condition of NDA approval, the FDA might require post-marketing testing and surveillance to monitor the drug’s
safety or efficacy, or they may impose other conditions.



After approval, certain changes to the approved product,
such as adding new indications, making certain manufacturing changes, or making certain additional labeling claims, are
subject to further FDA review and approval and may require the submission of a supplemental NDA. Before we could market our
product candidates for additional indications, we would have to obtain additional approvals from the FDA. Obtaining approval
for a new indication generally requires that additional clinical studies be conducted. We cannot ensure that any additional
approval for new indications, if any, for any product candidate would be approved.



Post-Approval Requirements



Often, even after a drug has been approved by the FDA for sale,
the FDA might require that certain post-approval requirements be satisfied, including the conduct of additional clinical studies.
If such post-approval conditions are not satisfied, the FDA might withdraw its approval of the drug. In addition, holders of an
approved NDA are required to:



| | · | report
                                                                                                             certain adverse reactions
                                                                                                             to the FDA;
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | comply
                                                                                                             with certain requirements
                                                                                                             concerning advertising
                                                                                                             and promotional labeling
                                                                                                             for their products;
                                                                                                             and
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | continue
                                                                                                             to have quality control
                                                                                                             and manufacturing
                                                                                                             procedures conform
                                                                                                             to cGMP after approval.
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



The FDA periodically inspects the sponsor’s
records related to safety reporting and/or manufacturing facilities, including an assessment of compliance with cGMP. Accordingly,
manufacturers must continue to expend time, money, and effort in the area of production and quality control to maintain cGMP compliance.
We intend to use, or have contracted with, third party manufacturers to produce our products in clinical quantities and in commercial
quantities for Northera, and we intend to do so with any future manufacturing needs. Future FDA inspections might identify compliance
issues at the facilities of our contract manufacturers that might disrupt production or distribution, or require substantial resources
to correct. In addition, discovery of problems with a product after any approval might result in restrictions on a product, manufacturer,
or holder of an approved NDA, including withdrawal of the product from the market.



15







Orphan Drug Designations



The FDA can grant orphan drug designation
to drugs intended to treat a rare disease or condition, which generally is a disease or condition that affects fewer than 200,000
individuals in the United States. Orphan drug designation must be requested before submitting an NDA. If the FDA grants orphan
drug designation, the identity of the therapeutic agent and its potential orphan use are publicly disclosed by the FDA. Orphan
drug designation does not necessarily convey an advantage in, or shorten the duration of, the review and approval process. If
a product which has an orphan drug designation subsequently receives the first FDA approval for the indication for which it has
such designation, the product is entitled to orphan exclusivity, meaning that the FDA will not approve any other applications
to market the same drug for the same indication for a period of seven years from approval, except in certain very limited circumstances.
Orphan drug designation does not prevent competitors from developing or marketing different drugs for that indication.



Regulations Outside the United States



Before our products can be marketed outside of the United States,
they are subject to regulatory approval similar to that required in the United States, although the requirements governing the
conduct of clinical trials, including additional clinical trials that might be required, product licensing, pricing and reimbursement
vary widely from country to country. No action can be taken to market any product in a country until an appropriate application
has been approved by the regulatory authorities in that country. The current approval process varies from country to country,
and the time spent in gaining approval varies from that required for FDA approval. In certain countries, the sales price of a
product must also be approved. The pricing review period often begins after market approval is granted. Even if a product is approved
by a regulatory authority, satisfactory prices might not be approved for such product.



In Europe, marketing authorizations may be submitted via a
centralized, decentralized or mutual recognition approach (or at a national level). The centralized procedure is mandatory for
the submission of high technology/biotechnology products, products with an orphan medicinal product designation, if filing for
indications contained in such designation, and certain therapeutic areas of community interest. This procedure provides for the
grant of a single marketing authorization that is valid in all European Union member states. It is optional for those products
and indications deemed innovative and also to generic products where the originator product was authorized via a centralized procedure.
The decentralized and mutual recognition procedures are available for those products not subject to a mandatory centralized procedure.
There can be no assurance that the chosen regulatory strategy will secure regulatory approvals on a timely basis or at all.



Manufacturing



We own no manufacturing facilities, quality control laboratories
or warehouses for storage and distribution of our product candidates. We intend to use, or have contracted with, third-party contractors
for manufacturing drug substances under development or planned for commercialization. We also use contractors for preformulation,
formulation and analytical development as well as manufacturing of drug products used for clinical studies. If any of our products
are approved by the FDA for marketing, we plan to use third-party contractors for producing the commercial product and have contracted
with manufacturers to do so for Northera in the event it is approved. This strategy enables us to direct our financial resources
to product development without devoting resources to the time and costs associated with building manufacturing plants and laboratories
and we plan on continuing this strategy for the foreseeable future.



We obtain the active pharmaceutical ingredient for droxidopa
from DSP pursuant to our exclusive license agreement with DSP. See “Management’s Discussion and Analysis of Financial
Condition and Results of Operations – License Agreement and Development Agreement Obligations” in Part II, Item 7
of this Report for a description of that agreement. We rely on Patheon Inc. with whom we have a manufacturing services agreement
to manufacture and package Northera.  Pursuant to the agreement,
we have the right to qualify an alternative manufacturer.



Intellectual Property



We actively seek to obtain, maintain and enforce patent
protection for our products, formulations, processes, methods and other proprietary technologies, preserve our trade secrets,
and operate without infringing on the proprietary rights of other parties, both in the United States and in other key markets.
Our goal is to obtain, where appropriate, the broadest intellectual property protection possible for our current product candidates,
including droxidopa, and any future product candidates and proprietary technologies through a combination of contractual arrangements
and patents, both in the United States and other countries.



16







Our patent estate for the antifolate portfolio includes three
issued U.S. patents, several issued patents outside the United States, four pending U.S. patent applications, a pending Patent
Cooperation Treaty (PCT) patent application and several related patent applications pending in countries outside the United States.
The issued U.S. patents are U.S. Patent No. 5,912,251, issued June 15, 1999, and U.S. Patent No. 7,829,708, issued November 9,
2010. In addition, on May 31, 2011, we were issued U.S. Patent No. 7,951,812 entitled “Substituted Pyrrolo[2,3-D]Pyridines
as Antifolates.” Issued and pending patent applications cover certain antifolate compounds, including claims to these compounds
as compositions of matter, in pharmaceutical formulations and for use in treatment of certain diseases



Our patent estate for droxidopa includes three issued U.S.
patents, several issued foreign patents, several pending U.S. patent applications and related patent applications pending in countries
outside the United States, including Europe. The pending applications are directed to pharmaceutical compositions comprising droxidopa
and therapeutic methods of treatment using droxidopa. The issued U.S. patents are U.S. Patent No. 8,383,681, issued February 26,
2013 and entitled “Droxidopa and Pharmaceutical Composition Thereof for the Treatment of Mood Disorders, Sleep Disorders,
or Attention Deficit Disorders”; U.S. Patent No. 8,008,285, issued August 31, 2011 and entitled “Droxidopa and Pharmaceutical
Compositions Thereof for the Treatment of Fibromyalgia,” and; U.S. Patent No. 8,158,149, issued April 17, 2012 and entitled
“Threo-DOPS Controlled Release Formulation.” We plan to continue to strengthen our patent estate on droxidopa by filing
and pursuing additional patents.



The patent estate for the I-3D portfolio includes U.S. Patent
No. 7,074,831, issued July 11, 2006, and U.S. Patent No. 8,263,658, issued September 11, 2012, several related issued patents
outside the United States, as well as a pending U.S. patent application and a number of related patent applications pending in
countries outside the United States.



Our success also depends upon the skills, knowledge and experience
of our scientific and technical personnel, our consultants and advisors, as well as our licensors and contractors. To help protect
our proprietary know-how and our inventions for which patents are unobtainable or difficult to obtain, we rely on trade secret
protection and confidentiality agreements. To this end, it is our policy to require all of our employees, consultants, advisors
and contractors to enter into agreements that prohibit the disclosure of confidential information and, where applicable, require
disclosure and assignment to us of the ideas, developments, discoveries and inventions important to our business.



Employees



We have attracted and retained a management team with core
competencies and expertise in numerous fields, including manufacturing, research, clinical, regulatory and business development.
Our management and advisors are comprised of experienced pharmaceutical and biotechnology industry veterans and respected experts.



At March 7, 2013, we had a total of 18 full time employees.
We believe the relationships with our employees are satisfactory. We anticipate that we will need to identify, attract, train
and retain other highly skilled personnel as needs should arise. Hiring for such personnel is competitive, and there can be no
assurance that we will be able to retain our key employees or attract, assimilate or retain the qualified personnel necessary
to support our business.



Where you can find additional information



Our website address is www.chelseatherapeutics.com. We make
available free of charge through our website our annual report on Form 10-K, quarterly reports on Form 10-Q, current
reports on Form 8-K, and all amendments to those reports as soon as reasonably practicable after such material is electronically
filed with or furnished to the SEC.



Executive Officers of the Registrant



The following table sets forth the name, age and position of
each of our executive officers as of March 7, 2013.



17







|Name                    |  | Age |  | Position                                                  
|----------------------- |  | --- |  | ----------------------------------------------------------
|                        |  |     |  |                                                           
|Joseph Oliveto          |  | 45  |  | Interim President and Chief Executive Officer             
|                        |  |     |  |                                                           
|J. Nick Riehle          |  | 60  |  | Vice President, Administration and Chief Financial Officer
|                        |  |     |  |                                                           
|William D. Schwieterman |  | 55  |  | Vice President, Chief Medical Officer                     
|                        |  |     |  |                                                           
|L. Arthur Hewitt        |  | 59  |  | Vice President, Chief Scientific Officer                  
|                        |  |     |  |                                                           
|Michael J. Roberts      |  | 43  |  | Vice President, Business Development                      



Joseph Oliveto, MBA – Interim
President and Chief Executive Officer. Mr. Oliveto was named Interim President and Chief Executive Officer in July 2012 in
conjunction with the resignation of our former CEO during the restructuring announced at that time. He joined us in June 2008
as Vice President of Operations following a two-year assignment as Executive in Residence at Pappas Ventures, a life sciences
venture capital firm. Prior to Pappas Ventures, he served in a number of progressively senior positions at Hoffmann-La Roche,
most recently as the Global Alliance Director for Roche's licensing organization. Previous experience at Roche includes clinical
development, project management, manufacturing process improvement and global business. During his tenure, he played an integral
part in the success of multiple NDA filings, developed comprehensive launch programs, including those for both Pegasys and Copegus,
and closed multiple licensing deals. Mr. Oliveto obtained a BA in Chemistry and an MBA from Rutgers University.



J. Nick Riehle, MBA – Vice President,
Administration and Chief Financial Officer.Mr. Riehle has been our Vice President, Administration and Chief Financial Officer
since July 2004. Prior to that he served as Chief Financial Officer at HAHT Commerce, Inc., a software company, from August 1996
until June 2003 and as an independent contractor from July 2003 until July 2004. Prior to that, Mr. Riehle served in various roles
at Nortel Networks and IBM. Mr. Riehle has his Bachelor of Commerce from McGill University, his MBA from York University and earned
a Certified Management Accountant (CMA) designation from Ontario, Canada.



William D. Schwieterman, M.D. –
Vice President, Chief Medical Officer.Dr. Schwieterman joined the company as an employee and officer in October 2009 after
serving for more than a year on our Board of Directors and several years as a consultant and member of our Scientific Advisory
Board for rheumatology.  He is a rheumatologist and board-certified internist who was formerly Chief of the Medicine Branch
and Chief of the Immunology and Infectious Disease Branch in the Division of Clinical Trials at the FDA. In these capacities and
others, Dr. Schwieterman spent 10 years at the FDA in the Center for Biologics overseeing a wide range of clinical development
plans for a large number of different types of molecules. Dr. Schwieterman helped author the FDA's "Good Review Practices"
for investigational products, and was instrumental in developing several guidance documents for the industry. After leaving the
FDA, he acted as an independent consultant to biotechnology and pharmaceutical companies, focusing on clinical drug development
and regulatory matters. He currently serves on the board of directors of OXiGENE, Inc., a publicly traded company, and Neumedics,
Inc., a privately held drug development company. Dr. Schwieterman holds a B.S. and M.D. from the University of Cincinnati.



L. Arthur Hewitt, Ph.D. – Vice
President, Chief Scientific Officer.Dr. Hewitt was named our Chief Scientific Officer in January 2010 after serving as our
Vice President, Drug Development since May 2004. Prior to that he served as an independent contractor from January 2003 to May
2004, as Director of Scientific Affairs at Shearwater Corporation, a drug delivery company, from October 2002 until January 2003
and as Director of Scientific Affairs for Amgen Canada from July 1991 until November 2000. During his years at Amgen, Dr. Hewitt
oversaw the approval of Neupogen, Stemgen and Infergen. Dr. Hewitt obtained his Ph.D. in Pharmacology from the Medical School
at the University of Montreal.



Michael J. Roberts, Ph.D. – Vice
President, Business Development. Dr. Roberts was named an officer of Chelsea in January 2010 after having served since August
2004 as Senior Director of Business Development. He joined us from Nektar Therapeutics where he was Director of Business Development
for their Molecule Engineering technology. Prior to this, he was Manager of Biopharmaceutical Research at Shearwater Corporation
where he led and was successful in the development of preclinical drug candidates from initial stages of research through Phase
I clinical study. Dr. Roberts obtained his Ph.D. in Materials Science from the University of Alabama in Huntsville and B.S. in
Chemical Engineering from Pennsylvania State University.



18







| | ITEM 1A. | RISK
                                                                                           FACTORS.
| | -------- | --------------------------------------------------------------------------------------------------------



Investment in our securities involves a high degree of risk.
You should consider carefully the risks described below, together with other information in this Annual Report on Form 10-K and
our other public filings, before making investment decisions regarding our securities. If any of the following events actually
occur, our business, operating results, prospects or financial condition could be materially and adversely affected. This could
cause the trading price of our common stock to decline and you may lose all or part of your investment. Moreover, the risks described
below are not the only ones that we face. Additional risks not presently known to us or that we currently deem immaterial may
also affect our business, operating results, prospects or financial condition. This Report contains forward-looking statements
that involve risks and uncertainties. Our actual results could differ materially from those discussed in this Report. Factors
that could cause or contribute to these differences include, but are not limited to, those discussed below and elsewhere in this
Report and in any documents incorporated in this Report by reference.



Risks Related to Our Business



We currently have no product revenue and will need to
raise additional capital to operate our business.



To date, we have generated no product revenue. Until, and unless,
we receive approval from the FDA and other regulatory authorities for our product candidates, we cannot sell our drugs and will
not have product revenue. Currently, our primary product candidates are droxidopa and our antifolates portfolio, and none are
approved by the FDA nor, with the exception of droxidopa, for which DSP has secured Japanese approval, any other regulatory agency
for sale. Therefore, for the foreseeable future, we will have to fund all of our operations and development expenditures from
cash on hand, equity or debt financings, licensing fees and grants. In 2012, our operating expenses totaled approximately $31.8
million, including non-cash items and the impact of our restructuring and we anticipate that 2013 operating expenses will be approximately
$18.2 million, including non-cash items. As of December 31, 2012, we had cash and cash equivalents of approximately $28.4 million.



In order to fund operations and increase our cash reserves,
we may seek to out-license our products or seek additional sources of financing and such opportunities might not be available
on favorable terms, if at all. If we do not succeed in raising additional funds on acceptable terms, we might not be able to complete
planned preclinical and clinical trials or obtain approval of any product candidates from the FDA and other regulatory authorities.
In addition, we could be forced to discontinue product development, forego attractive business opportunities or curtail operations.
Any additional sources of financing could involve the issuance of our equity securities, which would have a dilutive effect on
our stockholders.



We are not currently profitable and might never become
profitable.



We have a history of losses and expect to incur substantial
losses and negative operating cash flow for the foreseeable future, and we might never achieve or maintain profitability. Even
if we succeed in developing and commercializing one or more product candidates, we expect to incur substantial losses for the
foreseeable future and might never become profitable. From inception through December 31, 2012 we had a loss of $215.1 million.
We had net losses of $31.7 million for the year ended December 31, 2012 and net losses of $50.5 million and $37.3 million for
the years ended December 31, 2011 and 2010, respectively. Actual losses will depend on a number of considerations, including:



| | · | discussions
                                                                                                              with regulatory
                                                                                                              agencies concerning
                                                                                                              the design and results
                                                                                                              of our ongoing and/or
                                                                                                              future clinical
                                                                                                              trials and the criteria
                                                                                                              for obtaining approval
                                                                                                              to market Northera
                                                                                                              in the U.S.;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | the pace and
                                                                                                              success of development
                                                                                                              activities, primarily
                                                                                                              our clinical programs
                                                                                                              for Northera;
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | possible out-licensing
                                                                                                              of our product candidates;
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | seeking additional
                                                                                                              regulatory approvals
                                                                                                              for our various
                                                                                                              product candidates;
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | the pace of
                                                                                                              development of new
                                                                                                              intellectual property
                                                                                                              for our existing
                                                                                                              product candidates;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | in-licensing
                                                                                                              and development
                                                                                                              of additional product
                                                                                                              candidates;
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | implementing
                                                                                                              additional internal
                                                                                                              systems and infrastructure;
                                                                                                              and
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | changes in existing
                                                                                                              staffing levels.
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------



19







We also expect to experience negative
cash flow for the foreseeable future as we fund our operating losses. Should we raise additional funds by selling shares of common
stock or other securities convertible into common stock, the ownership interest of our existing stockholders will be diluted.
If we are not able to obtain financing when needed, we may be required to delay, reduce the scope of, or eliminate one or more
of our development programs or curtail operations. As a result, our business, financial condition and results of operations would
be materially harmed.



We are a development-stage company and might not be able
to commercialize any product candidates.



We are a development-stage company and
have not demonstrated our ability to perform the functions necessary for the successful commercialization of any product candidates.
The successful commercialization of any product candidates will require us to perform a variety of functions, including:



| | · | continuing to
                                                                                                             undertake pre-clinical
                                                                                                             development and clinical
                                                                                                             trials;
| | - | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | participating
                                                                                                             in regulatory approval
                                                                                                             processes;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | formulating and
                                                                                                             manufacturing products;
                                                                                                             and
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | conducting sales,
                                                                                                             marketing and distribution
                                                                                                             activities.
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Our operations have largely been limited
to organizing and staffing our company, negotiating in-licensing agreements with our partners, acquiring, developing and securing
our proprietary technology, participating in regulatory discussions with the FDA, the EMA and other regulatory agencies and undertaking
preclinical trials and clinical trials of our product candidates. While we began preparations for the commercialization of Northera
in late 2011 and the first half of 2012, these activities were curtailed upon receipt of the CRL and most of the personnel hired
for those commercialization activities have been terminated. Our current plan of operation is to continue pursuit of marketing
approval in the United States for Northera for use in the treatment of Neurogenic OH. We currently have no work underway with
respect to the clinical development of our other current drug candidates. Our operations provide a limited basis for you to assess
our ability to commercialize our product candidates and the advisability of investing in our securities.



Although we have announced plans to prepare and resubmit
an NDA for Northera, potentially with approval near the end of 2013, we cannot assure you that this NDA will be approved.



As previously announced, in February 2013
we received a response concerning an appeal we made to the FDA related to the CRL issued by the FDA in March 2012 with respect
to our Northera NDA. In their response, the FDA acknowledged that data strongly demonstrating a short-term clinical benefit would
be adequate for approval and that data from our Study 306B can be considered for approval of Northera. The FDA was also clear
that 306B data will remains subject to scrutiny, including careful review of sensitivities, possible site audits and other factors.
The FDA stated that approval using 306B as an additional efficacy study would only be possible based on the strength of
that study and its ability to provide substantial evidence of effectiveness. We anticipate that the FDA will in fact review the
study carefully. The FDA is under no obligation to approve Northera if they are not adequately satisfied with the data and analyses
presented, particularly within the context of the various issues raised in their CRL.



The FDA has expressed significant concern regarding the
data obtained from the largest enrolling site from Study 301 and might determine that this study cannot be used for the approval
of Northera.



In the CRL and in follow-up discussions with Chelsea, the FDA
expressed significant concern regarding disproportionate results from the highest enrolling site in Study 301.  We agreed
to and have submitted all source documentation from all patients at this site to the FDA. In addition, we have provided the
FDA with information pertaining to two additional post-study independent site visits, neither of which found any significant errors
in the conduct of the trial. These findings are in keeping with the official FDA site audit conducted during the review of the
Northera NDA. We have subsequently sponsored an independent “Directed Audit” of this center which supports, through
the lack of significant findings, the validity of the data from that site.  Regardless of the lack of audit findings, the
FDA has indicated that the data from this particular site has a very low level of variability and positively favors Northera, compared
to placebo, to a magnitude that is disproportionate to the data from the remainder of the clinical sites in the study.  If
the data from this site is removed from the overall analysis of the study, statistical significance of the study is lost on the
endpoint of dizziness, although a strong trend in favor of droxidopa still exists. The disproportionality of the data from the
single site invalidates study 301 from meeting the FDA’s single study acceptance guidance for drug approval.  Our current
understanding is that Study 301 remains useful as an efficacy study that, when combined with another positive efficacy study, might
provide the basis for an NDA resubmission which is reviewable for marketing authorization.  Should additional concerns or
findings be raised about that site or other aspects of Study 301 however, the potential exists that Study 301 would not considered
as a pivotal efficacy study and Chelsea would be required to submit two additional, positive efficacy trial results to support
review for approval.  Moreover, the existing level of concern about Study 301 is likely to elicit a higher level of scrutiny
from the FDA with regard to items such as disproportionate site effects and overall data quality in their review of Study 306B.



20







The delay in our clinical and registration programs for
Northera is likely to require additional financing.



The delays we have experienced to date to the approval
and planned commercial launch of Northera may require us to pursue additional sources of capital in order to cover
anticipated costs to obtain FDA approval, particularly if an additional clinical trial or trials are required in order to
satisfy the FDA’s requirement. The CRL issued by the FDA in March 2012 in response to our NDA for Northera included a
request by the FDA that we submit data from an additional positive study to support efficacy for Northera. While recent FDA
guidance now indicates that Study 306B might be adequate to meet this requirement, the FDA has also indicated that it would
rigorously review such a submission  and our submission might not receive approval. Given the likelihood that the FDA would
require a post-approval efficacy study, should approval be granted, as well as the uncertainty of a near-term approval, we
intend to discuss with the FDA a new clinical trial that would meet their requirements under either potential scenario. In
addition, the costs of a new clinical trial or cots to prepare any additional filings with the FDA, including a resubmission
of the Northera NDA, might prove to be significant.



We might not obtain the necessary U.S. or worldwide regulatory
approvals to commercialize any product candidates.



We cannot assure you that we will receive
the approvals necessary to commercialize our product candidates including Northera (droxidopa), our antifolates, or any other
product candidate either currently in our drug candidate portfolio or which we might acquire or develop in the future. We will
need FDA approval to commercialize our product candidates in the United States and approvals from equivalent regulatory authorities
in foreign jurisdictions to commercialize our product candidates in those jurisdictions. In order to obtain FDA approval of any
product candidate, we must submit to the FDA an NDA demonstrating that the product candidate is safe for humans and effective
for its intended use. This demonstration requires significant research and animal tests, which are referred to as preclinical
studies, as well as human tests, which are referred to as clinical trials. Satisfaction of the FDA’s regulatory requirements
typically takes many years, depends upon the type, complexity and novelty of the product candidate and requires substantial resources
for research, development and testing. We cannot predict whether our research and clinical approaches will result in drugs that
the FDA considers safe for humans and effective for indicated uses. The FDA has substantial discretion in the drug approval process
and may require us to conduct additional preclinical and clinical testing or to perform post-marketing studies. For example, the
CRL issued by the FDA in March 2012 in response to our NDA for Northera included a request by the FDA that we submit data from
an additional positive study to support efficacy for Northera and we plan to discuss with the FDA a new clinical trial in connection
with our planned resubmission of the Northera NDA. The approval process might also be delayed by changes in government regulation,
future legislation or administrative action or changes in FDA policy that occur prior to or during our regulatory review. Delays
in obtaining regulatory approvals might:



| | · | delay commercialization
                                                                                                             of, and our ability
                                                                                                             to derive product
                                                                                                             revenue from, a product
                                                                                                             candidate;
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | reduce available
                                                                                                             time during which
                                                                                                             our intellectual
                                                                                                             property is protected
                                                                                                             under various U.S.
                                                                                                             and foreign patents;
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | impose costly
                                                                                                             procedures on us;
                                                                                                             and
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | diminish any
                                                                                                             competitive advantages
                                                                                                             that we might otherwise
                                                                                                             enjoy.
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Even if we comply with all FDA requests, the FDA may reject
one or more of our NDAs. We cannot be sure that we will ever obtain regulatory clearance for any of our product candidates. Failure
to obtain FDA approval of product candidates will severely undermine our business and could substantially extend the period before
we have a saleable product, leaving us without any source of revenue until another product candidate can successfully be developed
and commercialized. There is no guarantee that we will ever be able to develop and commercialize or acquire another product candidate
or to obtain approval for any such additional product candidate that might be acquired.



In foreign jurisdictions, we must receive approval from the
appropriate regulatory authorities before we can commercialize any drugs. Foreign regulatory approval processes generally include
all of the risks associated with the FDA approval procedures described above. We cannot assure you that we will receive the approvals
necessary to commercialize product candidates for sale outside the United States.



Although we plan to evaluate strategic arrangements that
would be beneficial to our stockholders, we might not be successful.



With the announcement of our reorganization on July 10, 2012
we stated our intent to explore and evaluate all available strategic options to determine the best path forward for our Company
and our stockholders. Such options might include out-licensing of our products or even the merger or sale of the company. Despite
this intent, there is no guarantee that we will be able to successfully identify any such options that would be acceptable. Moreover,
if we are able to identify any acceptable options, we cannot provide assurances that we could be successful in negotiating any
such transaction on favorable terms, if at all, or that the terms of any such transaction would be sufficient to meet our capital
requirements. Such a transaction might also reduce the potential for future profits and/or negatively impact our stock price.



21







Our potential future earnings may be reduced should we
decide to out-license one or more of our drug product candidates.



We may decide to out-license one or more
of our drug product candidates, reducing future profits available to us. Should we license our drug product candidates to another
pharmaceuticals company, it would allow the partner to market and sell our compounds in one or more markets around the world.
If either the antifolates or droxidopa are licensed to a strategic partner, the profit available to us may be substantially reduced
from what might otherwise be possible should we retain all rights to the products and market and sell them directly.



We and certain of our executive officers and directors
have been named as defendants in recently initiated lawsuits that could result in substantial costs and divert management’s
attention.



We, and certain of our executive officers, have been named
as defendants in purported class action lawsuits that allege violations of federal securities laws related to various statements
regarding our development of Northera for the treatment of symptomatic Neurogenic OH and the likelihood of FDA approval. We intend
to engage in a vigorous defense of such litigation. Even if we were to be successful in the defense of the litigation, we could
incur substantial costs not covered by our directors’ and officers’ liability insurance, suffer a significant adverse
impact on our reputation and divert management’s attention and resources, which could have a material adverse effect on
our business. In addition, any settlement of the litigation could require payments that exceed the limits of our available directors’
and officers’ liability insurance, which could have a material adverse effect on our operating results or financial condition.
Additional similar lawsuits might be filed.



In addition, on May 2, 2012, a purported shareholder derivative
lawsuit was filed in the Delaware Court of Chancery against the members of our board of directors as of the date of the lawsuit. 
The complaint generally alleges that, from at least June 2011 through February 2012, the defendants breached their fiduciary duties
and otherwise caused harm to Chelsea in connection with various statements related to our development of Northera for the treatment
of neurogenic OH and the likelihood of FDA approval.  The complaint seeks unspecified damages, attorneys’ fees and
other costs.  On June 25, 2012, the Court of Chancery entered an Order staying the action until the U.S. District Court for
the Western District of North Carolina has ruled upon the motion to dismiss that we and our officers filed on November 16, 2012
in response to the consolidated complaint in the class action.



Our recent reduction in workforce and any possible future
reductions could adversely impact our ability to operate effectively.



On July 10, 2012 we announced changes to our Board of Directors
and senior management as well as a broad reorganization that included significant reductions in staff levels. While a number of
the employees eliminated had been hired as part of our commercialization plans for Northera which have now been delayed, other
staff positions eliminated provided support in areas other than commercialization activities. Moreover, certain of the commercialization
staff provided market intelligence and insights for our business development analyses and discussions. While some of these resources
may remain available on a consulting basis, their availability cannot be guaranteed. Similarly, while Dr. Simon Pedder, our former
CEO, and Keith Schmidt, our former Vice President of Sales and Marketing, are to continue providing support on a consulting basis,
we cannot be certain that either will remain available for such support or that they would be available to the extent required.
In addition, we saw an increase in the level of attrition during the latter half of 2012 as several employees tendered their resignations.
Given the difficulties in recruiting additional new hires at this time, we have decided not to fill these vacant positions immediately
and that could adversely impact our ability to conduct operations. Finally, additional reductions to staff levels may be required
or we might see additional attrition should other officers and/or employees choose to resign, further impacting our ability to
conduct our operations.



22







The FDA has suggested that if Northera is approved, its
label might carry a black box warning.



While we were not able to engage in active labeling discussions
with the FDA and certain sections will be subject to the completion and review of additional data submitted, the FDA made a preliminary
recommendation that the label for Northera include a black box warning to alert patients and physicians about the potential risk
of supine hypertension. However, the CRL also indicates that such a boxed warning could be reconsidered if suitable data demonstrating
a lack of severe hypertension in a fully prone position versus the 30-degree head-up tilt, the standard of care and criteria used
in our clinical program, were provided. We believe that use of the 30 degree head-up tilt was clinically appropriate and hope
to be able to mitigate the need for a black box warning after further discussions with the agency although we cannot provide assurances
that we will be successful. Alternatively, we might pursue a study of Northera’s effect on supine hypertension relative
to placebo in a fully prone position. However, given that the 30-degree head-up tilt is the standard of care, such a study design
may not meet the approval of investigators and/or ethics boards. Additionally, we might not be successful in demonstrating results
that would support the removal of a black box warning. A black box warning might reduce market acceptance for Northera and limit
its acceptance among insurance companies and other payers, which might limit the price we might otherwise be able to charge for
Northera, impede our ability to obtain reimbursement from payers or negatively impact sales volume, each of which might have a
material negative impact on our financial condition or results of operations.



The FDA indicated that additional bioequivalence work
would be needed to support the approval of a 300mg dose for Northera.



The FDA indicated in the CRL that additional bioequivalence
work would be required to support the approval of a 300mg dose for Northera. We had sought approval of a 300mg capsule to complement
the availability of 100mg and 200mg capsules utilized in our clinical trials for Northera. While we continue to review our options
with respect to this requirement and the possible timing of additional bioequivalence work, we can provide no assurances that
we can successfully obtain approval of a 300mg dose even if we are successful in obtaining approval to market Northera in the
United States. If we are unable to obtain approval of a 300mg capsule and launch, upon approval of Northera, with only 100mg and
200mg capsules available, patients using higher doses would be required to take additional capsules, potentially impacting compliance
and persistence rates and negatively impacting sales.



We have not determined any additional requirements that
may be needed in order to meet the expectations of the European Medicines Agency, or EMA, or other foreign regulatory agencies
in order to obtain marketing approval for Northera outside the United States.



Since an initial discussion several years ago, we
have only conducted limited discussions of the specifics of our clinical program with the EMA, and several individual
European Union, or EU, countries’ regulatory agencies, and we have not yet determined if our current program for
Northera in Neurogenic OH will be acceptable for approval in the EU, or any particular member country. While we continue to
believe that the safety data from Study 306B with an extended period of placebo control is better aligned with the
requirements as expressed by the EMA previously, we cannot be certain of this. In 2011, we conducted discussions with several
EU member country regulatory agencies to better understand their and, derivatively, the EMA’s expectations with regard
to their efficacy requirements. However, until we proceed further with those discussions it will not be clear that Study 301
and Study 302 data, along with data from the related extension studies and Study 306B data, will be sufficient for filing in
the EU. If not, we may be required to conduct additional clinical trials and, regardless, we cannot guarantee that Study 306B
data will show a significant symptomatic benefit for patients with Neurogenic OH to support approval or that any subsequent
trials will provide adequately favorable data.



There has been only very limited testing of our I-3D
product candidates.



Our I-3D product candidates are early in their development.
None of the candidates have had adequate toxicology testing in animals to permit clinical testing and there is no clinical evidence
of efficacy for any of these candidates, despite limited similarities with compounds currently marketed by others. Animal toxicology
trials on our I-3D compounds may not permit further development of these drugs or we may have to carry out toxicology trials on
several compounds before we find one that is appropriate for clinical testing, if at all. Once clinical trials are undertaken,
the compound or compounds may not prove adequately safe and efficacious in humans and may not be approved by the FDA or other
regulatory agencies. Moreover, because of the scarcity of capital and competing priorities within our development program we do
not know when we will be able to continue any such testing or commence clinical trials, if ever.



Clinical trials are very expensive, time-consuming and
difficult to design and implement.



Human clinical trials are very expensive and difficult to design
and implement, in part because they are subject to rigorous regulatory requirements. The clinical trial process is also time-consuming.
For example, because we did not receive orphan drug status from the EMA for droxidopa as a treatment for Parkinson’s disease,
our clinical trials for that indication might have to be more involved and take longer to complete and get reviewed than otherwise
would have been the case. Furthermore, failure can occur at any stage of the trials, and we could encounter problems that cause
us to abandon or repeat clinical trials. The commencement and completion of clinical trials might be delayed by several factors,
including:



23







| | · | unforeseen safety
                                                                                                             issues;
| | - | --------------------------------------------------------------------------------------------------------------------------------------

| | · | clarification
                                                                                                             of dosing issues;
| | - | --------------------------------------------------------------------------------------------------------------------------------------------

| | · | lack of effectiveness
                                                                                                             during clinical trials;
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | slower than expected
                                                                                                             rates of patient
                                                                                                             recruitment;
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | inability to
                                                                                                             monitor patients
                                                                                                             adequately during
                                                                                                             or after treatment;
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | inability or
                                                                                                             unwillingness of
                                                                                                             medical investigators
                                                                                                             to follow our clinical
                                                                                                             protocols; and
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | unexpected emergence
                                                                                                             of competitive drugs
                                                                                                             against which our
                                                                                                             compounds might compete
                                                                                                             for clinical trial
                                                                                                             resources or need
                                                                                                             to be tested.
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



In addition, we or the FDA or another governing regulatory
agency may suspend our clinical trials at any time if it appears that we are exposing participants to unacceptable health risks
or if the regulatory agency finds deficiencies in the conduct of these or our regulatory submissions. Therefore, we cannot predict
with any certainty the schedule for our current or any future clinical trials.



The results of our clinical trials might not support
our product candidate claims.



Even if our clinical trials are completed as planned, we cannot
be certain that their results will support our product candidate claims. Success in preclinical testing and early clinical trials
does not ensure that later clinical trials will be successful, and we cannot be sure that the results of later clinical trials
will replicate the results of prior clinical trials and preclinical testing. The clinical trial process might fail to demonstrate
that our product candidates are safe for humans and effective for indicated uses. This failure would cause us to abandon a product
candidate and might delay development of other product candidates. Any delay in, or termination of, our clinical trials will delay
the filing of our NDAs with the FDA and, ultimately, our ability to commercialize our product candidates and generate product
revenue.



We intend to explore additional indications for droxidopa,
however these programs may not prove successful.



We have announced our exploration of certain additional indications
for droxidopa and we may make similar announcements in the future. While trials conducted by DSP for the Japanese market provide
evidence of efficacy for certain indications, other indications may be explored for which we have no existing clinical evidence
of efficacy. Such trials are likely to be very costly. We do not have market approval from the FDA or other regulatory agencies
for any of the indications we are exploring and there are no guarantees that additional clinical trials will provide new evidence
of efficacy in the targeted indications or permit us to gain market approval from regulatory agencies.



Physicians and patients might not accept and use our
drugs.



Even if the FDA approves any of our product candidates, physicians
and patients might not accept and use them. Acceptance and use of our products will depend upon a number of factors including:



| | · | perceptions by
                                                                                                             members of the healthcare
                                                                                                             community, including
                                                                                                             physicians, about
                                                                                                             the safety and effectiveness
                                                                                                             of our drug candidates;
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | cost-effectiveness
                                                                                                             of our product relative
                                                                                                             to competing products;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | understanding
                                                                                                             by prescribing physicians
                                                                                                             of the medical conditions
                                                                                                             we are attempting
                                                                                                             to address;
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | availability
                                                                                                             of reimbursement
                                                                                                             for our product from
                                                                                                             government or other
                                                                                                             healthcare payers;
                                                                                                             and
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | effectiveness
                                                                                                             of marketing and
                                                                                                             distribution efforts
                                                                                                             by us and our licensees
                                                                                                             and distributors,
                                                                                                             if any.
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Because we expect that sales of our product candidates could,
if approved, generate a substantial portion of our product revenue for an extended period, the failure of such a drug to find
market acceptance would harm our business and could require us to seek additional financing or curtail our operations.



24







Our drug development program depends upon third-party
researchers who are outside our control.



We depend upon independent clinical research organizations,
investigators and other collaborators, such as universities and medical institutions, to conduct our preclinical and clinical
trials under agreements with us. These collaborators are not our employees and we cannot control the amount or timing of resources
that they devote to our programs. They might not assign as great a priority to our programs or pursue them as diligently as we
would if we were undertaking such programs ourselves. If outside collaborators fail to devote sufficient time and resources to
our drug development programs, if their performance is substandard or the FDA determines there are issues upon review of the study
data, the approval of our FDA applications, if any, and our introduction of new drugs, if any, will be delayed. If we cannot successfully
enter into new agreements with outside collaborators on acceptable terms, or if we encounter disputes over or cannot renew or,
if necessary, amend existing agreements, the development of our drug candidates could be delayed. These collaborators might also
have relationships with other commercial entities, some of which might compete with us. If our collaborators assist our competitors
at our expense, our competitive position would be harmed.



Our drug development program also depends upon other
parties who are outside our control.



We have licensed certain rights related to droxidopa from DSP
and depend upon them for data and support in advancing our clinical program for this compound. Our licensing agreement with DSP
grants us an exclusive, worldwide, sub-licensable license, with certain geographic restrictions, and rights to droxidopa including,
but not limited to all information, formulations, materials, data, drawings, sketches, designs, testing and test results, records
and regulatory documentation. In addition, DSP is currently the preferred manufacturer of this compound for our clinical program
and commercialization efforts. Without the timely support of DSP, our drug development programs could suffer significant delays,
require significantly higher spending or face cancellation.



We rely exclusively on third parties to formulate and
manufacture any product candidates.



We have only limited experience in drug formulation and no
experience in drug manufacturing and do not intend to establish our own manufacturing facilities. We lack the resources and expertise
to formulate or manufacture our own product candidates. While we have a contract in place with DSP and another manufacturer for
droxidopa for our clinical trials and possible commercialization, we currently have no contract for the commercial scale manufacture
of our antifolates or I-3D compounds. We have contracted with one or more manufacturers to manufacture, supply, store and distribute
drug supplies for our antifolate clinical trials. If any of our current product candidates or any other product candidates that
we may develop or acquire in the future receive FDA approval, we will rely on one or more third-party contractors to manufacture
our drugs. Our anticipated future reliance on a limited number of third-party manufacturers exposes us to risks, including that:



| | · | We might not
                                                                                                               be able to identify
                                                                                                               manufacturers on
                                                                                                               acceptable terms
                                                                                                               or at all because
                                                                                                               the number of potential
                                                                                                               manufacturers is
                                                                                                               limited and the
                                                                                                               FDA must approve
                                                                                                               any replacement
                                                                                                               contractor. This
                                                                                                               approval would
                                                                                                               require new testing
                                                                                                               and compliance
                                                                                                               inspections. In
                                                                                                               addition, a new
                                                                                                               manufacturer would
                                                                                                               have to be educated
                                                                                                               in, or develop
                                                                                                               substantially equivalent
                                                                                                               processes for,
                                                                                                               production of our
                                                                                                               products after
                                                                                                               receipt of FDA
                                                                                                               approval, if any.
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | Our third-party
                                                                                                               manufacturers might
                                                                                                               be unable to formulate
                                                                                                               and manufacture
                                                                                                               our drugs in the
                                                                                                               volume and of the
                                                                                                               quality required
                                                                                                               to meet our clinical
                                                                                                               needs and commercial
                                                                                                               needs, if any,
                                                                                                               or limitations
                                                                                                               in their capacity
                                                                                                               could limit the
                                                                                                               timely availability
                                                                                                               of our product,
                                                                                                               which could alienate
                                                                                                               prescribing physicians
                                                                                                               and/or their patients
                                                                                                               if we cannot meet
                                                                                                               their demand for
                                                                                                               our drugs.
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | Our contract
                                                                                                               manufacturers might
                                                                                                               not perform as
                                                                                                               agreed or might
                                                                                                               not remain in the
                                                                                                               contract manufacturing
                                                                                                               business for the
                                                                                                               time required to
                                                                                                               supply our clinical
                                                                                                               trials or to successfully
                                                                                                               produce, store
                                                                                                               and distribute
                                                                                                               our products.
| | - | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | Our contract
                                                                                                               manufacturers might
                                                                                                               require financial
                                                                                                               assistance to increase
                                                                                                               their capacity
                                                                                                               levels required
                                                                                                               for our markets.
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| | · | Our contract manufacturers have competing clients and/or competing products that vie for production scheduling.
Drug manufacturing lead times for droxidopa are long. The increased risk associated with not securing timely production scheduling
slots could lead to not having adequate supplies for launch should Northera be approved or face gaps in commercial supply and
“stock outs” after launch.                                                                                                                                                                                                                                                                                                                                                                                                        

| | · | Drug manufacturers
                                                                                                               are subject to
                                                                                                               ongoing periodic
                                                                                                               unannounced inspection
                                                                                                               by the FDA, the
                                                                                                               Drug Enforcement
                                                                                                               Administration,
                                                                                                               or DEA, and corresponding
                                                                                                               state agencies
                                                                                                               to ensure strict
                                                                                                               compliance with
                                                                                                               good manufacturing
                                                                                                               practice and other
                                                                                                               government regulations
                                                                                                               and corresponding
                                                                                                               foreign standards.
                                                                                                               We do not have
                                                                                                               control over third-party
                                                                                                               manufacturers’
                                                                                                               compliance with
                                                                                                               these regulations
                                                                                                               and standards.
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Each of these risks could delay our clinical trials, the approval,
if any, of our product candidates by the FDA or the commercialization of our product candidates or result in higher costs or deprive
us of potential product revenue.



25







If we cannot compete successfully for market share against
other drug companies, we might not achieve sufficient product revenue and our business will suffer.



The market for our antifolate product candidates is characterized
by intense competition and rapid technological advances. The initial market for droxidopa, while smaller, has well established
generic competition. Other markets for droxidopa, such as fibromyalgia, are emerging with new and heavily marketed offerings.
If our antifolates, droxidopa or other product candidates receive FDA approval, they will compete with a number of existing and
future drugs and therapies developed, manufactured and marketed by others. Existing or future competing products might provide
greater therapeutic convenience, efficacy or other benefits for a specific indication than our products or might offer comparable
performance at a lower cost. If our products fail to capture and maintain market share, we will not achieve sufficient product
revenue and our business will suffer.



We will compete against fully integrated pharmaceutical companies
and smaller companies that are collaborating with larger pharmaceutical companies, academic institutions, government agencies
and other public and private research organizations. Many of these competitors have compounds already approved or in development.
In addition, many of these competitors, either alone or together with their collaborative partners, operate larger research and
development programs or have substantially greater financial resources than we do, as well as significantly greater experience
in:

| | • | developing drugs;                                         
| | - | ----------------------------------------------------------
| | • | undertaking preclinical testing and human clinical trials;
| | • | obtaining FDA and other regulatory approvals of drugs;    
| | • | formulating and manufacturing drugs;                      
| | • | launching, marketing and selling drugs; and               
| | • | post-marketing safety surveillance.                       



Our ability to generate product revenue will be diminished
if our drugs sell for inadequate prices or patients are unable to obtain adequate levels of reimbursement.



Our ability to commercialize our drugs, alone or with collaborators,
will depend in part on the extent to which reimbursement will be available from:

| | • | government and health administration authorities;                    
| | - | ---------------------------------------------------------------------
| | • | private health maintenance organizations and health insurers;
    and
| | • | other healthcare payers.                                             



Significant uncertainty exists as to the reimbursement status
of newly approved healthcare products. Healthcare payers, including Medicare, are challenging the prices charged for medical products
and services. Government and other healthcare payers increasingly attempt to contain healthcare costs by limiting both coverage
and the level of reimbursement for drugs. Even if a product candidate is approved by the FDA, insurance coverage might not be
available and reimbursement levels might be inadequate to cover our drug. If government and other healthcare payers do not provide
adequate coverage and reimbursement levels for our product, once approved, market acceptance and our revenue could be reduced.



Specifically, not all physicians recognize a separate indication
for symptomatic Neurogenic OH and we cannot provide assurances that reimbursement will be approved by the relevant decision makers
even if droxidopa receives market approval from the FDA or other regulatory authorities.



In addition, the U.S. and international healthcare industry
is subject to changing political, economic and regulatory influences that may significantly affect the purchasing practices and
pricing of pharmaceuticals. The laws and regulations governing and issued by the FDA and other healthcare policies might change,
and additional government regulations might be enacted, which could prevent or delay regulatory approval of our product candidates.
In March 2010, the U.S. Congress passed landmark healthcare legislation. We cannot predict what impact on federal reimbursement
policies this legislation will have in general or on our business specifically. We anticipate that the U.S. Congress and state
legislatures will continue to review and assess this legislation and possibly alternative health care reform proposals. The U.S.
Congress may adopt additional legislation that could have the effect of putting downward pressure on the prices that pharmaceutical
and biotechnology companies can charge for prescription drugs, including the proposed healthcare reform legislation. Cost-containment
measures, whether instituted by healthcare providers or imposed by government health administration regulators or new regulations,
could result in greater selectivity in the purchase of drugs. As a result, healthcare payers might challenge the price and cost
effectiveness of our products. In addition, in many major markets outside the United States, pricing approval is required before
sales may commence. As a result, significant uncertainty exists as to the reimbursement status of approved healthcare products.



26









Developments by competitors might render our products
or technologies obsolete or non-competitive.



Companies that currently sell compounds used for the treatment
of orthostatic hypotension include Apotex, Mylan Pharmaceuticals, Impax Laboratories, Sandoz, Teva, Upsher-Smith Laboratories and
Pfizer. Companies that currently sell both generic and proprietary compounds for the treatment of rheumatoid arthritis include,
but are not limited to, Abbott Laboratories, Amgen, Pfizer, Sanofi-Aventis, Boehringer Ingelheim Pharma, Hoffmann-La Roche, Johnson
& Johnson, Bristol-Myers Squibb, Mylan Laboratories and UCB. Alternative technologies are being developed to treat rheumatoid
arthritis by numerous companies including Rigel, Astra Zeneca and GSK which are in advanced clinical trials or filed with regulatory
agencies. In addition, companies pursuing different but related fields represent substantial competition. Many of these organizations
competing with us have substantially greater capital resources, larger research and development staffs and facilities, longer drug
development history in obtaining regulatory approvals and greater manufacturing and marketing capabilities than we do. These organizations
also compete with us to attract qualified personnel and parties for acquisitions, joint ventures or other collaborations.



Our success, competitive position and future revenue
will depend in part on our ability to obtain and maintain patent protection for our products, methods, processes and other technologies,
to preserve our trade secrets, to prevent third parties from infringing on our proprietary rights and to operate without infringing
the proprietary rights of third parties.



We do not know whether any of our pending patent applications
or those patent applications that we may file or license in the future will result in the issuance of any patents. Moreover, we
cannot predict the degree of patent protection that will be afforded by those patent applications that do result in issuance.
Although we generally seek the broadest reasonable patent protection available for our proprietary compounds, we may not be able
to obtain patent protection for the actual composition of any particular compound and may be limited to protecting a new method
of use for the compound or otherwise restricted in our ability to prevent others from exploiting the compound. If our patent protection
for any particular compound is limited to a particular method of use or indication such that, if a third party were to obtain
approval of the compound for use in another indication, we could be subject to competition arising from off-label use.



Moreover, our issued patents and those that may issue in the
future, or those licensed to us, may be challenged, invalidated, rendered unenforceable or circumvented, any of which could limit
our ability to stop competitors from marketing related products. In addition, the rights granted under any issued patents may
not provide us with competitive advantages against competitors with similar compounds or technologies. Furthermore, our competitors
may independently develop similar technologies in a manner that does not infringe our patents or other intellectual property.



If a third party legally challenges our patents or other intellectual
property rights that we own or license, we could lose certain of these rights. For example, third parties may challenge the validity
of our U.S. or foreign patents through reexaminations, oppositions or other legal proceedings. If successful, a challenge to our
patents or other intellectual property rights could deprive us of competitive advantages and permit our competitors to use our
technology to develop similar products.



In addition, we do not anticipate having patent protection
on droxidopa when and if it receives market approval by the FDA for Neurogenic OH under the brand name NortheraTM. While
the orphan drug designation for this compound by the FDA will provide seven years of market exclusivity, we will not be able to
exclude other companies from manufacturing and/or selling this compound beyond that timeframe.



Claims by third parties that we infringe their proprietary
rights may result in liability for damages or prevent or delay our developmental and commercialization efforts.



If a third party were to file a patent infringement suit against
us, we could be forced to stop or delay research, development, manufacturing or sales of any infringing product in the country
or countries covered by the patent infringed, unless we can obtain a license from the patent holder. Any necessary license may
not be available on acceptable terms or at all, particularly if the third party is developing or marketing a product competitive
with the infringing product. Even if we are able to obtain a license, the rights may be nonexclusive, which would give our competitors
access to the same intellectual property. We also may be required to pay substantial damages to the patent holder in the event
of an infringement. If we have supplied infringing products to third parties for marketing or have licensed third parties to manufacture,
use or market infringing products, we may be obligated to indemnify these third parties for any damages they may be required to
pay to the patent holder and for any losses they may sustain themselves as a result.



27







We may initiate patent litigation against third parties
to protect or enforce our patent rights. Failure to protect our patents and other proprietary rights may materially harm our business,
financial condition and results of operations.



Legal or administrative proceedings may be necessary to defend
against claims of infringement or to enforce our intellectual property rights. If we become involved in any such proceeding, irrespective
of the outcome, we may incur substantial costs, and the efforts of our technical and management personnel may be diverted, which
could materially harm our business. Furthermore, because of the substantial amount of discovery required in connection with intellectual
property litigation, there is a risk that disclosure of some of our confidential information could be compelled and the information
compromised. In addition, during the course of this kind of litigation, there could be public announcements of the results of
hearings, motions or other interim proceedings or developments that, if perceived as negative by securities analysts or investors,
could have a substantial adverse effect on the trading price of our common stock.



Existing patents and proprietary rights could harm our
competitive position.



Other entities may have or obtain patents or proprietary rights
that could limit our ability to manufacture, use, sell, offer for sale or import products or impair our competitive position.
In addition, to the extent that a third party develops new technology that covers our products, we may be required to obtain licenses
to that technology, which licenses might not be available or may not be available on commercially reasonable terms, if at all.
Our failure to obtain a license to any technology that we require may materially harm our business, financial condition and results
of operations.



Changes in either patent laws or in interpretations of
patent laws in the United States and other countries may diminish the value of our intellectual property or narrow the scope of
our patent protection.



The laws of foreign countries may not protect our rights to
the same extent as the laws of the United States. Therefore, enforceability or scope of our patents in the United States or in
foreign countries cannot be predicted with certainty, and, as a result, any patents that we own or license may not provide sufficient
protection against competitors.



Some jurisdictions have laws that permit the government to
force a patentee to grant a license to a third party for commercialization of a patented product if the government concludes that
the product is not sufficiently developed or not meeting the health needs of the population. Such compulsory licensing laws are
very rarely invoked outside of South America and Africa. In addition, a number of countries limit the enforceability of patents
against government agencies or government contractors. In these countries, the patent owner may be limited to monetary relief
and may be unable to enjoin infringement, which could materially diminish the value of the patent. Such compulsory licenses could
be extended to include some of our product candidates, which may limit our potential revenue opportunities.



Because of the extensive time required for development, testing
and regulatory review of a new drug, it is possible that any related patent may expire before any of our product candidates can
be commercialized or remain in force for only a short period following commercialization. In either case, this would reduce any
advantages of the patent.



If we are unable to satisfy our obligations under current
and future license agreements, we could lose license rights which would adversely affect our business.



We license patent and/or certain other rights from DSP for
droxidopa. Similarly, we are a party to a license agreement with Dr. M. Gopal Nair under which we license patent rights for our
product candidate CH-4051 and other antifolates. We may enter into additional licenses in the future. Our existing licenses impose,
and we expect future licenses will impose, various milestone payments, royalty payments and other obligations on us. If we fail
to comply with our obligations in our intellectual property licenses with third parties, we could lose license rights that are
important to our business. If a licensor challenges our license position, our competitive position and business prospects could
be harmed.



Our license agreement with DSP reserves rights to the licensor
in Japan, Korea, China and Taiwan which preclude our commercialization of droxidopa in those markets. Our license agreement with
Dr. Nair reserves rights to the licensor in India. Therefore, we will not commercialize our products in these respective markets.



28







If we are unable to enforce trade secret protection and
confidentiality agreements with our employees, our competitive position might be harmed.



Our success also depends upon the skills, knowledge and experience
of our scientific and technical personnel, our consultants and advisors, as well as our licensors and contractors. To help protect
our proprietary know-how and our inventions for which patents are unobtainable or difficult to obtain, we rely on trade secret
protection and confidentiality agreements. To this end, it is our policy to require all of our employees, consultants, advisors
and contractors to enter into agreements that prohibit the disclosure of confidential information and, where applicable, require
disclosure and assignment to us of the ideas, developments, discoveries and inventions important to our business. These agreements
might not provide adequate protection for our trade secrets, know-how or other proprietary information in the event of any unauthorized
use or disclosure or the lawful development by others of such information. If any of our trade secrets, know-how or other proprietary
information is disclosed, the value of our trade secrets, know-how and other proprietary rights would be significantly impaired
and our business and competitive position would suffer.



If we infringe the rights of third parties we could be
prevented from selling products, forced to pay damages and defend against litigation.



If our products, methods, processes and other technologies
infringe the proprietary rights of other parties, we could incur substantial costs and we might have to:

| | • | obtain licenses, which might not be available on
    commercially reasonable terms, if at all;                                                                                        
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| | • | abandon an infringing drug candidate;                                                                                                                                                 
| | • | redesign our products or processes to avoid infringement;                                                                                                                             
| | • | stop using the subject matter claimed in the patents held by
    others;                                                                                                              
| | • | pay damages; or                                                                                                                                                                       
| | • | defend litigation or administrative proceedings, which might
    be costly whether we win or lose, and which could result in a substantial diversion of valuable management resources.



We might not successfully manage our growth.



We are a small, development stage company. Should we obtain
approval for any of our product candidates, our success will depend upon the expansion of our operations and the effective management
of our growth, which will place a significant strain on our management and on our administrative, operational and financial resources.
As of March 7, 2012, we had 18 full-time, permanent employees. If we are unable to manage our growth effectively, our business
would be harmed.



We might be exposed to liability claims associated with
the use of hazardous materials and chemicals.



Our research and development activities might involve the controlled
use of hazardous materials and chemicals. Although we believe that our safety procedures, and those of our partners, for using,
storing, handling and disposing of these materials comply with federal, state, local and, where applicable, foreign laws and regulations,
we cannot completely eliminate the risk of accidental injury or contamination from these materials. In the event of such an accident,
we could be held liable for any resulting damages and any liability could materially adversely affect our business, financial
condition and results of operations. In addition, the laws and regulations governing the use, manufacture, storage, handling and
disposal of hazardous or radioactive materials and waste products might require us to incur substantial compliance costs that
could materially adversely affect our business, financial condition and results of operations.



We rely on key executive officers and scientific and
medical advisors, and their knowledge of our business and technical expertise would be difficult to replace.



As a small, development stage company, we are highly dependent
on our executive officers, including our principal scientific, regulatory, and medical officers and advisors.
We do not have “key person” life insurance policies for any of our officers. The loss of the technical knowledge and
management and industry expertise of any of our key personnel could result in delays in product development, loss of any future
customers and sales and diversion of management resources, which could adversely affect our operating results.



If we are unable to hire additional qualified personnel,
our ability to grow our business will be harmed.



As a small, development stage company, we currently employ
qualified personnel with expertise in preclinical testing, clinical research and testing, government regulation, formulation and
manufacturing and administration. We compete for qualified individuals with numerous pharmaceutical and biopharmaceutical companies,
universities and other research institutions. In the third quarter of 2012, we instituted a corporate reorganization in which
we eliminated virtually all sales and marketing personnel whom we had previously hired in anticipation of the commercial launch
of Northera. To commercialize Northera on our own in the future, we would need to rehire appropriate sales and marketing personnel.
Competition is intense for qualified individuals in all areas of pharmaceutical development and commercialization and we cannot
be certain that any search for such personnel will be successful.



29







We might incur substantial liabilities and might be required
to limit commercialization of our products in response to product liability lawsuits.



The testing and marketing of medical products entail an inherent
risk of product liability. If we cannot successfully defend ourselves against product liability claims, we might incur substantial
liabilities or be required to limit commercialization of our products. Our inability to obtain sufficient product liability insurance
at an acceptable cost to protect against potential product liability claims could prevent or inhibit the commercialization of
our products. Although we carry clinical trial insurance, we might not be able to renew such insurance at a reasonable cost, if
at all, or our intended collaborators may be unable to obtain such insurance at a reasonable cost, if at all. Even if our agreements
with any future collaborators entitle us to indemnification against losses, that indemnification might not be available or adequate
should any claim arise.



Risks Related to Our Common Stock



Based upon recent trading prices, our common stock could
potentially face delisting from the NASDAQ Capital Market.



Under NASDAQ rules, companies listed on
the NASDAQ Capital Market are required to maintain a share price of at least $1.00 per share and if the share price declines below
$1.00 for a period of 30 consecutive business days, then the listed company would have 180 days to regain compliance with the $1.00
per share minimum. On January 28, 2013 the Listing Qualifications Staff of the NASDAQ Stock Market notified
us that we no longer complied with the minimum $1.00 per share requirement for continued listing on the NASDAQ Capital Market as
set forth in NASDAQ Listing Rule 5550(a)(2).  However, as of March 5, 2013, the share price of our common stock had closed
above $1.00 for 10 consecutive trading days, such that we had regained compliance with the minimum share price requirement. 
In the event that our share price falls below $1.00 for 30 consecutive business days in the future, we may be required to take
additional actions, such as a reverse stock split, in order to comply with the NASDAQ rules that may be in effect at the time.
Such actions might negatively impact the trading price of our common stock.



If we are not able to comply with the minimum share price or other listing standards of the NASDAQ Capital
Market, our common stock may be delisted from the NASDAQ Capital Market that could negatively impact our liquidity in the market
for our common stock.



The prices at which shares of our common stock are traded
will likely be volatile.



You should expect the prices at which our common stock is traded
to be highly volatile. Since the commencement of trading on The NASDAQ Capital Market in May 2006, the price has varied from a
low of $0.70 to a high of $8.41. The expected volatile price of our stock will make it difficult to predict the value of your
investment, to sell your shares at a profit at any given time, or to plan purchases and sales in advance. A variety of other factors
might also affect the market price of our common stock. These include, but are not limited to:

| | · | publicity regarding
                                                                                                               actual or potential
                                                                                                               clinical results
                                                                                                               relating to products
                                                                                                               under development
                                                                                                               by our competitors
                                                                                                               or us;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | delays or failures
                                                                                                               in initiating,
                                                                                                               completing or analyzing
                                                                                                               preclinical or
                                                                                                               clinical trials
                                                                                                               or the unsatisfactory
                                                                                                               design or results
                                                                                                               of these trials;
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | success or
                                                                                                               delays in commercialization
                                                                                                               of our product
                                                                                                               candidates;
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | market acceptance
                                                                                                               of our product
                                                                                                               candidates;
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | obtaining,
                                                                                                               delays in or rejection
                                                                                                               of regulatory approvals
                                                                                                               for our products
                                                                                                               or our competitor’s
                                                                                                               products by U.S.
                                                                                                               or foreign regulators;
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | announcements
                                                                                                               of technological
                                                                                                               innovations or
                                                                                                               new commercial
                                                                                                               products by our
                                                                                                               competitors or
                                                                                                               us;
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | developments
                                                                                                               concerning proprietary
                                                                                                               rights, including
                                                                                                               patents;
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | developments
                                                                                                               concerning our
                                                                                                               collaborations;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | regulatory
                                                                                                               developments in
                                                                                                               the United States
                                                                                                               and foreign countries;
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------





30









| | · | economic or
                                                                                                               other crises and
                                                                                                               other external
                                                                                                               factors;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | period-to-period
                                                                                                               fluctuations in
                                                                                                               our results of
                                                                                                               operations;
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | changes in
                                                                                                               financial estimates
                                                                                                               by securities analysts;
                                                                                                               and
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | sales of our
                                                                                                               common stock.
| | - | -----------------------------------------------------------------------------------------------------------------------------------------



We will not be able to control many of these factors, and we
believe that period-to-period comparisons of our financial results will not necessarily be indicative of our future performance.



In addition, the stock market in general, and the market for
pharmaceutical companies in particular, has experienced extreme price and volume fluctuations that might have been unrelated or
disproportionate to the operating performance of individual companies. These broad market and industry factors might seriously
harm the market price of our common stock, regardless of our operating performance.



We have never paid dividends and do not intend
to pay cash dividends.

We currently anticipate that no cash dividends will be paid
on our common stock in the foreseeable future. While our dividend policy will be based on the operating results and capital needs
of the business, it is anticipated that all earnings, if any, will be retained to finance our future operations.



If securities analysts downgrade our stock or cease coverage
of us, the price of our stock could decline.

The trading market for our common stock relies in part on the
research and reports that industry or financial analysts publish about us or our business. Currently, five financial analysts
publish reports about us and our business. We do not control these or any other analysts. Furthermore, there are many large, well-established,
publicly traded companies active in our industry and market, which may mean that it is less likely that we will receive widespread
analyst coverage. If any of the analysts who cover us downgrade our stock, our stock price would likely decline rapidly. If these
analysts cease coverage of our company, we could lose visibility in the market, which in turn could cause our stock price to decline.



Substantial future sales of our common stock in the public
market may depress our stock price and make it difficult for you to recover the full value of your investment in our shares of
common stock.

As of December 31, 2012, we had 67,075,779 shares of common
stock outstanding. Substantially all of these shares are available for public sale, subject in some cases to volume and other
limitations or delivery of a prospectus. The market price of our common stock may decline if our common stockholders sell a large
number of shares of our common stock in the public market, or the market perceives that such sales may occur. In addition, we
have outstanding options and warrants to purchase an aggregate of 7,076,070 and 2,023,530 shares, respectively, of our common
stock. If these options or warrants are exercised and the shares issued upon exercise are sold, the market price of our securities
may also decline. These factors also could impair our ability to raise needed capital by depressing the price at which we could
sell our securities.



| | ITEM 1B. | UNRESOLVED
                                                                                         STAFF COMMENTS.
| | -------- | -------------------------------------------------------------------------------------------------------------------



None.



| | ITEM 2. | PROPERTIES.
| | ------- | -----------



We currently lease 13,979 square feet of office space in Charlotte,
North Carolina. This lease, as amended in October 2010, currently requires monthly payments of approximately $30,000. The lease
will expire in March 2016. The agreement calls for annual rent increases of 3%. Under the terms of the lease, a security deposit
equal to two months’ rent, or approximately $38,000, was returned to us in 2012. We believe that our current facilities
are adequate to meet our needs to later 2013 or early 2014.



| | ITEM 3. | LEGAL
                                                                                        PROCEEDINGS.
| | ------- | ----------------------------------------------------------------------------------------------------------



Following the receipt of the CRL from the FDA regarding the
NDA for NortheraTM (droxidopa) in March 2012 and the subsequent decline of the price of our common stock, two purported class
action lawsuits were filed on April 4, 2012 and another purported class action lawsuit was filed on May 1, 2012 in the U.S. District
Court for the Western District of North Carolina against us and certain of our executive officers.



31







The complaints generally allege that, during differing class
periods, all of the defendants violated Sections 10(b) of the Exchange Act and Rule 10b-5 and the individual defendants violated
Section 20(a) of the Exchange Act in making various statements related to our development of Northera for the treatment of
symptomatic neurogenic OH and the likelihood of FDA approval. The complaints seek unspecified damages, interest, attorneys’
fees, and other costs. Following consolidation of the three lawsuits and the appointment of a lead plaintiff, a consolidated complaint
was filed on October 5, 2012, on behalf of purchasers of our common stock from November 3, 2008 through March 28, 2012. We and
our officers intend to vigorously defend against this lawsuit but are unable to predict the outcome or reasonably estimate a range
of possible loss at this time.



On May 2, 2012, a purported shareholder derivative lawsuit
was filed in the Delaware Court of Chancery against the members of our board of directors as of the date of the lawsuit. 
The complaint generally alleges that, from at least June 2011 through February 2012, the defendants breached their fiduciary duties
and otherwise caused harm to the Company in connection with various statements related to our development of Northera for the
treatment of Neurogenic OH and the likelihood of FDA approval.  The complaint seeks unspecified damages, attorneys’
fees and other costs.  On June 25, 2012, the Court of Chancery entered an Order staying the action until the U.S. District
Court for the Western District of North Carolina has ruled upon the motion to dismiss that we and our officers have filed on November
16, 2012 in response to the consolidated complaint in the class action.



| | ITEM 4. | MINE
                                                                                        SAFETY DISCLOSURES.
| | ------- | ----------------------------------------------------------------------------------------------------------------



Not applicable.



| | ITEM 5. | MARKET
                                                                                       FOR THE REGISTRANT’S COMMON EQUITY,
                                                                                       RELATED STOCKHOLDER MATTERS AND ISSUER
                                                                                       PURCHASES OF EQUITY SECURITIES.
| | ------- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Our common stock is traded on the NASDAQ Capital Market under
the symbol “CHTP”. The following table sets forth the high and low prices of our common stock for the reported periods,
as reported by the NASDAQ Capital Market.



|                                    |  | High |      |  | Low |  
|----------------------------------- |  | ---- | ---- |  | --- | -
|Fiscal year ended December 31, 2011 |  |      |      |  |     |  
|First Quarter                       |  | $    | 8.15 |  |     | $
|Second Quarter                      |  | $    | 5.34 |  |     | $
|Third Quarter                       |  | $    | 5.89 |  |     | $
|Fourth Quarter                      |  | $    | 5.63 |  |     | $
|                                    |  |      |      |  |     |  
|Fiscal year ended December 31, 2012 |  |      |      |  |     |  
|First Quarter                       |  | $    | 5.36 |  |     | $
|Second Quarter                      |  | $    | 2.35 |  |     | $
|Third Quarter                       |  | $    | 1.46 |  |     | $
|Fourth Quarter                      |  | $    | 1.87 |  |     | $



As of March 6, 2013, the last sale price of our common
stock on the NASDAQ Capital Market was  $1.77 per share. As of March 5, 2013, there were approximately 230 stockholders of
record, as derived from our shareholder records excluding beneficial owners of our common stock whose shares are held in the
name of various dealers, clearing agencies, banks, brokers and other fiduciaries.



For a discussion of outstanding options, warrants and other
securities exercisable for, or convertible into, shares of our common stock, please see Note 7 of the financial statements under
Item 8 in this Annual Report on Form 10-K.



We have neither paid nor declared dividends on our common stock
since our inception and do not plan to pay dividends in the foreseeable future. Any earnings that we may realize will be reinvested
to finance our operations.



32







The market prices for securities of pharmaceutical companies,
including ours, have historically been highly volatile, and the market has from time to time experienced significant price and
volume fluctuations that are unrelated to the operating performance of particular companies. Factors, such as regulatory actions,
clinical trial results, public concern as to the safety of drugs developed by us or others, fluctuations in our operating results,
announcements of technological innovations or new therapeutic products by us or others, developments concerning agreements with
collaborators, governmental regulation, developments in patent or other proprietary rights, future sales of substantial amounts
of common stock by existing stockholders and general market conditions, can have an adverse effect on the market price of our
common stock.



| | ITEM 6. | SELECTED
                                                                                                                            FINANCIAL
                                                                                                                            DATA.
| | ------- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



The following table sets forth financial
data with respect to us as of and for the five years ended December 31, 2012 and the period from April 3, 2002 (inception) through
December 31, 2012. The selected financial data below should be read in conjunction with the audited financial statements and related
notes included elsewhere in this Annual Report on Form 10-K and "Management's Discussion and Analysis of Financial Condition
and Results of Operations" included in Item 7.



|                                                                           |  |                                                     |            |   |                  |   |            |      |  |   |            |   |  |      |            |   | Period from   |  
|-------------------------------------------------------------------------- |  | --------------------------------------------------- | ---------- | - | ---------------- | - | ---------- | ---- |  | - | ---------- | - |  | ---- | ---------- | - | ------------- | -
|                                                                           |  |                                                     |            |   |                  |   |            |      |  |   |            |   |  |      |            |   | April 3, 2002 |  
|                                                                           |  |                                                     |            |   |                  |   |            |      |  |   |            |   |  |      |            |   | (Inception)   |  
|                                                                           |  |                                                     |            |   |                  |   |            |      |  |   |            |   |  |      |            |   | through       |  
|                                                                           |  | Years
    ended December 31,                        |            |   | December
    31, |  
|                                                                           |  | 2012                                                |            |   | 2011             |   |            | 2010 |  |   | 2009       |   |  | 2008 |            |   | 2012          |  
|                                                                           |  | (In thousands, except share
    and per share data) |           
|Statement of Operations Data:                                              |  |                                                     |            |   |                  |   |            |      |  |   |            |   |  |      |            |   |               |  
|Operating expenses:                                                        |  |                                                     |            |   |                  |   |            |      |  |   |            |   |  |      |            |   |               |  
|Research
    and development                                               |  | $                                                   | 16,744     |   |                  | $ | 37,270     |      |  | $ | 30,871     |   |  | $    | 23,985     |   |               | $
|Sales and marketing                                                        |  |                                                     | 7,222      |   |                  |   | 8,068      |      |  |   | 2,476      |   |  |      | 2,289      |   |               |  
|General and administrative                                                 |  |                                                     | 5,680      |   |                  |   | 5,276      |      |  |   | 4,155      |   |  |      | 4,076      |   |               |  
|Restructuring                                                              |  |                                                     | 2,158      |   |                  |   | -          |      |  |   | -          |   |  |      | -          |   |               |  
|Total
    operating expenses                                               |  |                                                     | 31,804     |   |                  |   | 50,614     |      |  |   | 37,502     |   |  |      | 30,350     |   |               |  
|                                                                           |  |                                                     |            |   |                  |   |            |      |  |   |            |   |  |      |            |   |               |  
|Operating loss                                                             |  |                                                     | (31,804    | ) |                  |   | (50,614    | )    |  |   | (37,502    | ) |  |      | (30,350    | ) |               |  
|Interest income, net of
    expense                                        |  |                                                     | 68         |   |                  |   | 162        |      |  |   | 172        |   |  |      | 188        |   |               |  
|Other
    income (expense)                                                 |  |                                                     | -          |   |                  |   | -          |      |  |   | -          |   |  |      | 4,390      |   |               |  
|                                                                           |  |                                                     |            |   |                  |   |            |      |  |   |            |   |  |      |            |   |               |  
|Net
    loss                                                               |  | $                                                   | (31,736    | ) |                  | $ | (50,452    | )    |  | $ | (37,330    | ) |  | $    | (25,772    | ) |               | $
|                                                                           |  |                                                     |            |   |                  |   |            |      |  |   |            |   |  |      |            |   |               |  
|Net
    loss per basic and diluted share of common stock                   |  | $                                                   | (0.47      | ) |                  | $ | (0.84      | )    |  | $ | (0.91      | ) |  | $    | (0.82      | ) |               | $
|                                                                           |  |                                                     |            |   |                  |   |            |      |  |   |            |   |  |      |            |   |               |  
|Weighted
    average number of basic and diluted common shares outstanding |  |                                                     | 66,892,982 |   |                  |   | 60,136,326 |      |  |   | 41,184,623 |   |  |      | 31,549,739 |   |               |  





|                                                 |  | As of December 31, |         
|------------------------------------------------ |  | ------------------ | --------
|                                                 |  | 2012               |         
|                                                 |  | (in thousands)     |         
|Balance Sheet Data:                              |  |                    |         
|Cash and cash equivalents                        |  | $                  | 28,425  
|Short-term investments, net                      |  |                    | -       
|Working capital                                  |  |                    | 25,765  
|Long-term investments, net                       |  |                    | -       
|Total assets                                     |  |                    | 28,928  
|Line of credit payable                           |  |                    | -       
|Deficit accumulated during the development stage |  |                    | (215,061
|Total stockholders' equity                       |  |                    | 25,916  





33







ITEM 7.            MANAGEMENT’S
DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS.



The following discussion of our financial
condition and results of operations should be read in conjunction with the financial statements and the notes to those statements
included elsewhere in this Annual Report on Form 10-K. This discussion contains predictions, estimates and other forward-looking
statements that involve a number of risks and uncertainties, including those discussed under “Risk Factors” and elsewhere
in this Annual Report on Form 10-K. These risks could cause our actual results to differ materially from those anticipated in
these forward-looking statements.



Overview



We are a development stage pharmaceutical company that seeks
to acquire, develop and commercialize innovative products for the treatment of a variety of human diseases. Our strategy is to
develop technologies that address important unmet medical needs or offer improved alternatives to current methods of treatment.
Specifically, we are developing droxidopa, a novel therapeutic agent for the treatment of symptomatic neurogenic orthostatic hypotension,
or Neurogenic OH, in patients with primary autonomic failure, dopamine β-hydroxylase, or DBH, deficiency and non-diabetic
autonomic neuropathy. We also have interest in evaluating the potential therapeutic applications of droxidopa in other potentially
norepinephrine related conditions and diseases including intradialytic hypotension, or IDH, fibromyalgia and adult attention deficit
hyperactivity disorder. In addition, we have a portfolio of metabolically inert antifolates that we have studied as a potential
treatment of rheumatoid arthritis and that might also be suitable for the treatment of multiple other autoimmune disorders including
psoriasis, Crohn’s disease, uveitis, ankylosing spondylitis, inflammatory bowel disease, cancer and other immunological
disorders.



NortheraTM (droxidopa),
our most advanced investigational product candidate, is an orally-active synthetic precursor of norepinephrine being developed
for the treatment of symptomatic Neurogenic OH. In Japan, Northera has been approved since 1989 and is marketed by Dainippon Sumitomo
Pharma Co., Ltd., or DSP, for the treatment of frozen gait and dizziness on standing in PD, orthostatic hypotension, syncope and
dizziness on standing in multiple systems atrophy (Shy-Drager Syndrome) and familial amyloid polyneuropathy and symptoms of orthostatic
hypotension in hemodialytic patients. During 2007, the FDA granted orphan drug status to Northera for the treatment of symptomatic
Neurogenic OH in patients with PAF, DBH deficiency and non-diabetic autonomic neuropathy and the European Medicines Agency, or
EMA, granted orphan medicinal product designation for the treatment of patients with Pure Autonomic Failure, or PAF, and patients
with multiple system atrophy, or MSA. In the U.S., orphan drug status provides seven years
of marketing exclusivity from the date of approval and designation as a new chemical entity in the European Union provides for
10 years of marketing exclusivity.



Following receipt of the complete response letter, or CRL,
from the FDA in March 2012 as more fully described below, we have been working with the FDA to clarify the requirements for
obtaining marketing approval for Northera in the U.S.  To obtain further clarity from the FDA, we
utilized a formal appeals process that involved the review of the issues presented in the CRL and all other subsequent guidance
received from the FDA. The review was led by the Director for the Center for New Drugs and included other senior officials within
the FDA, including representatives from the Center for Drug Evaluation I along with officials from the FDA Cardiovascular and Renal
Drug Products Division, or CRDP. Subsequent to that review, we received written guidance from the FDA and
were able to provide an update on our plans to move forward with our Northera registration program. The FDA has indicated
that it will allow the use of Study 306B as supportive evidence of both efficacy and safety in a Northera New Drug
Application, or NDA, for review by the CRDP. As such, we plan to resubmit our Northera NDA to the FDA, seeking approval to
market Northera. We currently anticipate that the NDA resubmission will take place in the second quarter of 2013. Under
the Prescription Drug User Fee Act, or PDUFA, the FDA’s goal would be to review and act on the NDA, if accepted for
review, in the fourth quarter of 2013.



The resubmission of the Northera NDA will include data from
our three completed Phase III efficacy studies (Studies 301, 302, 306A and 306B), an integrated summary of efficacy, an expanded,
650-patient safety database, two long-term, open label extension studies, a dedicated thorough QTc study and a 24-hour ambulatory
blood pressure monitoring study. The FDA has further informed us that an acute symptomatic endpoint, one demonstrating short-term
therapeutic benefit, may be sufficient evidence of efficacyrequired for approval and that durability
of response, as measured by long-term symptomatic benefit, may be shown in a post-approval study.





34







While the FDA’s updated 2013 guidance is
encouraging, the FDA was clear that Study 306B data remains subject to scrutiny, including a thorough review of data
sensitivities and that the FDA might conduct  audits of clinical sites, the CRO involved in the study and the sponsor.
Approval using data from Study 306B in support of efficacy claims for Northera would only be possible based on the strength
of that data and its ability to provide substantial evidence of efficacy. As such, the FDA is under no obligation to approve
Northera if they are not adequately satisfied with the data presented and we cannot provide any assurance that the FDA
will approve Northera. The FDA might require additional clinical evidence or might choose to approve Northera with a
requirement for a post-approval efficacy study. Accordingly, we plan to initiate an additional clinical study of Northera in
Neurogenic OH, the design of which will be finalized following additional discussions with the FDA. We anticipate that this
study would begin in the fourth quarter of 2013.



The receipt of the CRL in March 2012 followed a
September 2011 submission and a November 2011 acceptance of our initial Northera NDA. In February 2012, a meeting of the
Cardiovascular and Renal Drugs Advisory Committee, or CRDAC, was held, at the request of the FDA, to review and discuss the
Northera NDA. The CRDAC recommended, in a 7 to 4 vote, that the FDA approve our NDA to market Northera in the United
States. Notwithstanding that recommendation, on March 28, 2012, we announced that the FDA had issued the CRL regarding our
Northera NDA. The CRL included a request by the FDA that we submit data from an additional positive study to support efficacy
and, at that time, the FDA recommendations suggested that such a study be designed to demonstrate durability of effect over a
2- to 3-month period. Subsequent discussions with the CRDP and the Office of Drug Evaluation I in 2012 suggested that Study
306B might not be acceptable based on the theoretical potential for un-blinding. However, as discussed above, the FDA has now
provided guidance that we can now utilize data from Study 306B to seek marketing approval in the United States. The FDA
noted that data strongly demonstrating a short-term clinical benefit (e.g., improvement in symptoms or ability to function)
of droxidopa in patients with Neurogenic OH would be adequate for approval, with a possible requirement to verify
durable clinical benefit post-approval.



Prior to our NDA filing in September 2011, we had completed
two Phase III efficacy trials, Studies 301 and 302, of Northera for the treatment of symptomatic Neurogenic OH in patients with
primary autonomic failure. The improvements in the symptoms of Neurogenic OH, as measured by the orthostatic hypotension questionnaire
composite score, or OHQ composite, associated with Northera treatment in our pivotal efficacy Study 301 are highly significant
(p<0.003). Northera showed similar improvements (p<0.05) in OHQ composite scores in a post-hoc analysis of Study 302 data.
We had also completed, at the request of the FDA, a QTc study. A QT interval is a measure of time between the start of the Q wave
and the end of the T wave in the heart’s electrical cycle. In general, a prolonged QT interval is a biomarker for ventricular
tachyarrhythmias and can be a risk factor for sudden death. The results of this trial showed that Northera, at either therapeutic
or supra-therapeutic doses, did not increase heart rate or prolong AV conduction or cardiac polarization times as measured by
the PR interval, QT interval and duration of the QRS complex.



Given the concerns raised by the FDA at the End-of-Review
meeting, or EOR, held in May 2012, regarding results from the highest enrolling site in Study 301, we submitted all
information pertaining to two independent site visits, neither of which revealed any significant errors in the conduct of the
trial, which was consistent with the positive findings from the FDA pre-approval inspection conducted during the review of
the Northera NDA. Further, we have submitted all source documentation from all patients at the site and engaged independent,
third-party quality experts to confirm the validity of data from the site. Notwithstanding this information, the FDA has and
continues to maintain that the concentration and pattern of positive results at this site preclude Study 301 meeting the
criteria for a single-study approval, on which our NDA had been prepared.



Although modified by subsequent guidance, in June 2012, the
FDA advised that, based on the theoretical potential for un-blinding, Study 306B was unlikely to provide sufficient confirmatory
evidence to support a Northera NDA. Soon after receipt of the written response from the FDA, we stopped enrolling patients in
our Study 306B. Total enrollment was completed with 174 patients randomized, representing the single largest placebo-controlled
study ever conducted in Neurogenic OH. In addition, we modified the primary endpoint of Study 306B to the mean change in OHSA
item #1 score (dizziness, lightheadedness, feeling faint or “feeling like you might black out”) at visit 4 (one-week
post titration). The rate of patient reported falls was a secondary efficacy endpoint of the study. In December 2012, we announced
that preliminary results of Study 306B showed that the primary endpoint of the study had been met. The results showed that treatment
with Northera provided clinically meaningful and statistically significant improvements compared to placebo in dizziness/lightheadedness
at week 1 (1.0 unit change; p=0.018), the primary endpoint. In addition, compared to placebo, a statistically significantly
greater number of patients were observed to experience 2, 3 or 4 unit improvements at week 1 compared to baseline (all p-values
< 0.05). Study results also demonstrated a statistically significant increase in standing systolic blood pressure (SBP)
at week 1 (5.6 mmHg; p=0.032), an important secondary endpoint of the study. At time points beyond week 1, dizziness/lightheadedness
and standing blood pressure predominantly favored Northera-treated patients, although the results were not statistically significant.



35







Treatment with Northera also resulted in a reduction in the
rate of patient falls over the course of Study 306B, although these results were not statistically significant.  Patients
receiving placebo experienced a rate of falls per patient per week of 2.0 vs. 0.4 for those on Northera, an 80% reduction. Because
several patients on placebo experienced a very large number of falls, we performed multiple sensitivity analyses on this outcome. These
analyses showed that the beneficial effect of Northera on falls was evident even if the top 2, 5 or 10 fallers from each treatment
group were removed (34%, 36% and 29% reduction, respectively, p=NS). Importantly, the falls data were supported by additional
safety data showing that 34% fewer patients receiving Northera experienced fall-related injuries (e.g., contusions, lacerations,
fractures) than patients receiving placebo (placebo=25.6% vs. Northera=16.9%, p=NS). Both the reduction in falls and fall-related
injuries associated with Northera are consistent with results observed in Study 306A. Preliminary safety data showed that Northera
was well tolerated at all dosages tested and, as in prior studies, the incidence of supine hypertension was low.



In December 2011, we announced that we had received a notice
of allowance from the U.S. Patent and Trademark Office for our patent “Threo-DOPS Controlled Release Formulation.”
U.S. Patent No. 8,158,149. This patent was issued in April 2012 and will expire in 2028. The newly allowed claims relate to certain
oral, controlled release formulations of Northera that include an extended release component and an immediate release component.
Although we are not currently seeking regulatory approval for such a controlled release formulation of Northera, if we were to
do so, the patent would provide protection for the claimed formulation beyond the seven-year marketing exclusivity afforded by
its orphan designation in the U.S. Also, in September 2011, we announced that we had been issued U.S. Patent No. 8,008,285 entitled
“Droxidopa and pharmaceutical composition thereof for the treatment of fibromyalgia.” The claims of the patent are
related to methods of reducing pain associated with fibromyalgia by administering droxidopa alone, or in combination with other
specified medications.



In December 2011, we announced top-line results from our Phase
II trial of droxidopa, alone and in combination with carbidopa, for the treatment of fibromyalgia. Top-line results of the study
indicate a dose response with the highest dose of droxidopa, 600mg three times daily, demonstrating a 6.2-point average improvement
from a baseline score of 23.00 on the Short Form McGill Pain Questionnaire, or SF-MPQ, at the end of the nine-week treatment period,
the study’s primary endpoint. This reflects a 3.2 unit improvement over placebo on the SF-MPQ total pain score. Although
the study, conducted under approval from the United Kingdom’s Medicines and Healthcare Products Regulatory Agency, was not
designed to demonstrate statistical significance given the limited number of patients per arm, results of the study show a mean
change in pain, as measured by the visual analog scale, or VAS, of -1.64 for patients treated with droxidopa monotherapy compared
to a mean change of -0.90 for placebo. Assessment using the Fibromyalgia Index Questionnaire, or FIQ, showed patients treated
with droxidopa monotherapy demonstrated a mean change from baseline of -9.72 compared to -4.74 reported by patients in the placebo
arm. Administration of droxidopa monotherapy proved more effective than droxidopa/carbidopa combination therapy in the study.



In July 2011, we announced positive top-line results of an
investigator-led Phase II clinical study of droxidopa in combination with carbidopa in 20 adults with ADHD indicating that droxidopa
dramatically improved patients’ mean score on the adult ADHD Investigator Symptom Rating Scale, or AISRS. The AISRS is a
standardized, validated rating scale for assessing symptoms of adult ADHD and for measuring response to treatment. Upon enrollment,
patients in the study had a mean AISRS score of 34. After three weeks of open-label droxidopa monotherapy (titration from 200mg-600mg
TID), the mean AISRS score decreased by approximately 47% to 19 (p<0.0001). The reduction in AISRS score was maintained with
the addition of carbidopa (25mg or 50mg) for another three weeks.



In September 2012, preliminary data from an investigator-led,
Phase II study to evaluate droxidopa for the treatment of orthostatic hypotension resulting from spinal cord injury, or SCI,
suggests that low to moderate doses of droxidopa do not worsen supine increases in blood pressure in persons with SCI.  Although
droxidopa increased seated blood pressure in a dose-dependent manner, subjects remained relatively hypotensive.  Additional
studies will be necessary to determine the effective dose of droxidopa that normalizes blood pressure in this population.



In addition to droxidopa, we have devoted resources to the
development of a portfolio of molecules for the treatment of various autoimmune/inflammatory diseases. The most advanced platform
is a portfolio of metabolically-inert antifolate molecules engineered to have potent anti-inflammatory and anti-tumor activity
to treat a range of immunological disorders, including two clinical stage product candidates designated as CH-1504 and CH-4051.



36







CH-1504 has completed Phase II trials in rheumatoid arthritis.
While we do not intend to conduct additional trials or make further investments in the development of CH-1504, clinical work related
to this compound might provide meaningful informative data supporting the development of additional compounds in this portfolio.
Based on preclinical and clinical findings to date, we have more recently focused our clinical resources on the development of
CH-4051, the second clinical stage compound in this portfolio and the more potent L-enantiomer of CH-1504. CH-4051 has been studied
in rheumatoid arthritis as its lead indication, having completed a Phase I trial in April 2009 and a Phase II trial for the treatment
of rheumatoid arthritis in May 2012.



In November 2011, we announced results from an interim analysis
of unblinded efficacy data from the lower two of three doses of CH-4051 and half of the patients enrolled into the methotrexate,
or MTX, control arm in our multinational, 12-week, double-blind Phase II trial of CH-4051 in patients with rheumatoid arthritis,
designed to compare the efficacy and tolerability of CH-4051 against MTX. MTX is currently the leading antifolate treatment and
standard of care for a broad range of abnormal cell proliferation diseases. This data suggested a dose-dependent therapeutic response
in which patients treated with the mid-range, or 1.0 mg daily oral dose, of CH-4051 experienced similar efficacy to patients treated
with a standard 20.0 mg weekly dose of MTX.



In May 2012, we announced the top-line results of this trial
conducted in 244 patients with rheumatoid arthritis who experience an inadequate response to methotrexate treatment. Results of
this trial indicated that CH-4051 did not demonstrate superior efficacy to methotrexate in the dose range evaluated. CH-4051 was
found to be safe and well-tolerated in the study, with no dose-limiting toxicities or clear differences in the overall adverse
event rate between methotrexate and the CH-4051 treatment groups.



While management believes that higher doses of CH-4051 might
provide enhanced therapeutic benefit in rheumatoid arthritis and that CH-4051 could be developed for other anti-inflammatory and
autoimmune indications, we determined that current resources would be better allocated toward the planned completion of the Northera
development program in Neurogenic OH. As such, there are no immediate plans to continue the development of CH-4051 although we
do continue to pursue potential out-licensing opportunities for this portfolio of molecules.



Complementing our autoimmune/inflammatory program is a second
platform consisting of a portfolio of therapeutics targeting immune-mediated inflammatory disorders and transplantation, known
as our I-3D portfolio. We currently have no work underway related to this portfolio.



Since inception we have focused primarily on organizing and
staffing our company, negotiating in-licensing agreements with our partners, acquiring, developing and securing our proprietary
technology, participating in regulatory discussions with the FDA, the EMA and other regulatory agencies, raising capital and undertaking
preclinical trials and clinical trials of our product candidates. In addition, during late 2011 and early 2012, prior to the date
we received the CRL, we had initiated activities to support the planned commercialization of Northera. We are a development stage
company and have generated no revenue since inception. We do not anticipate
generating any product revenue until and unless we successfully obtain approval from the FDA or equivalent foreign regulatory
bodies to begin selling Northera or any of our other pharmaceutical candidates although we could potentially generate revenue
prior to any marketing approval by entering into strategic agreements including out-licensing, co-development or co-promotion
of our drug candidates.Developing pharmaceutical products is a lengthy and expensive process. Currently, development and
commercialization expenses are being funded with proceeds from equity financings completed in December 2004, February 2006, March
2007, November 2007, July 2009, March 2010, October 2010, February 2011 and January 2012 and, to a lesser extent, proceeds from
the exercise of warrants and options. Given our intent to initiate an additional clinical trial and continue our efforts to secure
marketing approval for Northera, along with the uncertainty regarding the approval of Northera and potential product revenue should
approval be obtained, our need to finance operating costs might continue. Such funding might be provided by securing a partnering
arrangement for one or more of our product candidates that would also provide access to additional expertise in conducting these
activities. Accordingly, our success depends not only on the safety and efficacy of our product candidates, but also on our ability
to finance the development and/or commercialization of the products.



Revenue and Cost of Revenue



We have not generated any revenue from licensing, milestones
or product sales through December 31, 2012. We do not expect to generate product revenue until and unless we receive approval
from the FDA or other regulatory authorities to market our product candidates. We may also attempt to out-license one or more
of our drug product candidates and, if successful, we would anticipate revenue to be recorded from such a transaction. However,
we might never be able to generate revenue or generate revenue sufficient to fund ongoing operations. Other than Northera, which,
if approved by the FDA, could be launched in 2014, at the earliest, none of our other product candidates are expected to be commercially
available until, at the earliest, 2018, if at all.



37







Research and Development



Research and development expenses consist primarily of costs
associated with determining feasibility, licensing and preclinical and clinical testing of our licensed pharmaceutical candidates,
including salaries and related personnel costs, fees paid to consultants and outside service providers for drug manufacture and
development, certain legal expenses and other expenses. All of our major research and development projects subject us to drug
development and regulatory risks, including specifically risks of delays and cost over-runs that could be material to our financial
condition and results of operations. For certain programs, we might rely on collaborative partners or our ability to enter into
collaborations on favorable terms in order to advance a product candidate and pay a portion of the research and development expenses.
See “Item 1A. Risk Factors.” We expense our research and development costs as they are incurred. Research and development
expenses, related to our major research and development projects, for the years ended December 31, 2012, 2011 and 2010 were approximately
$16.7 million, $37.3 million and $30.9 million, respectively, and are detailed as follows:



|               |  |                              |        |  |                     |   |        |      |  |   | Period from       | 
|-------------- |  | ---------------------------- | ------ |  | ------------------- | - | ------ | ---- |  | - | ----------------- | 
|               |  |                              |        |  |                     |   |        |      |  |   | April 3, 2002     | 
|(in thousands) |  | Years ended December
    31, |        |  | (inception) through |  
|               |  | 2012                         |        |  | 2011                |   |        | 2010 |  |   | December 31, 2012 | 
|Antifolates    |  | $                            | 3,550  |  |                     | $ | 7,350  |      |  | $ | 6,100             | 
|Droxidopa      |  |                              | 13,200 |  |                     |   | 29,950 |      |  |   | 24,800            | 
|I-3D           |  |                              | -      |  |                     |   | -      |      |  |   | -                 | 
|               |  | $                            | 16,750 |  |                     | $ | 37,300 |      |  | $ | 30,900            | 



Sales and Marketing



Selling and marketing expenses consist primarily of salaries
and related expenses that support our business development activity, including programs related to our patents and intellectual
property. During 2012 and earlier periods, these costs also included promotional initiatives, activities related to the branding,
pricing and market analysis of our pharmaceutical compounds and the initial steps taken to establish a Northera sales force in
the United States.



General and Administrative



General and administrative expenses focus on the support of
administrative activities and consist primarily of salaries and related expenses for executive, finance and other administrative
personnel, recruitment expenses for such personnel, consulting and professional fees and other corporate expenses, including general
legal and accounting activities, certain taxes and other government fees and facilities-related expenses.



Corporate History



Our operating company, Chelsea Therapeutics, Inc., or Chelsea
Inc., was incorporate in Delaware in April 2002 under the name Aspen Therapeutics, Inc. Its name was changed in July 2004. In
February 2005, we completed a merger with Ivory Capital Corporation, or Ivory, a publicly traded Colorado corporation, in which
a wholly owned subsidiary of Ivory Capital was merged with and into Chelsea Inc. and Chelsea Inc. became a wholly owned subsidiary
of Ivory. The merger resulted in a change of control of Ivory, with the former stockholders of Chelsea Inc. owning approximately
96.75% of the resulting entity, after assuming the conversion of all outstanding options and warrants. In addition, the terms
of the merger provided that the sole officer and director of Ivory would be replaced by the officers and directors of Chelsea
Inc. The transaction was accounted for as a reverse acquisition with Chelsea Inc. as the acquiring party and Ivory as the acquired
party, in substance, a reorganization of Chelsea Inc. Accordingly, when we refer to our business and financial information relating
to periods prior to the merger, we are referring to the business and financial information of Chelsea Inc. unless the context
indicates otherwise. On July 28, 2005, Ivory merged with Chelsea Therapeutics International, Ltd., or Chelsea Ltd., with Chelsea
Ltd. as the surviving corporation. As a result, Chelsea Ltd. is the public reporting company and is the 100% owner of Chelsea
Inc., its operating subsidiary.



38







When we refer to business and financial information for periods
between January 1, 2005 and July 28, 2005, we are referring to the business and financial information of Ivory. Except as noted,
all share numbers included herein reflect the conversion of every nine shares of Ivory Capital Corporation common stock for one
share of Chelsea Ltd. common stock that occurred in connection with our Delaware reincorporation on July 28, 2005.



Results of Operations



The tables below set forth, for the periods
indicated, certain items in our consolidated statements of operations and other pertinent financial and operating data.



Comparison of Years ended December 31, 2012 and 2011



(in thousands, except percentages)



|                                   |  | For the      |        |  | For the      |   |        |          |  |   |         |  
|---------------------------------- |  | ------------ | ------ |  | ------------ | - | ------ | -------- |  | - | ------- | -
|                                   |  | year ended   |        |  | year ended   |   |        |          |  |   |         |  
|                                   |  | December 31, |        |  | December 31, |   |        | $        |  |   | %       |  
|                                   |  | 2012         |        |  | 2011         |   |        | Increase |  |   | Change  |  
|Research and development expense   |  | $            | 16,744 |  |              | $ | 37,270 |          |  | $ | (20,526 | )
|Sales and marketing expense        |  |              | 7,222  |  |              |   | 8,068  |          |  |   | (846    | )
|General and administrative expense |  |              | 5,680  |  |              |   | 5,276  |          |  |   | 404     |  
|Restructuring                      |  |              | 2,158  |  |              |   | -      |          |  |   | 2,158   |  
|Interest income                    |  |              | 68     |  |              |   | 162    |          |  |   | (94     | )



Research and development expenses. During 2012, we continued
to incur costs for Study 306B and our open-label extension study, Study 304, and had expenses for our now completed Phase II trial
of CH-4051 in rheumatoid arthritis. We also incurred costs of approximately $0.2 million to support the preparation for the FDA
requested meeting of the CRDAC held in February 2012 and our EOR meeting with the FDA held in May 2012. Specifically, expenses
for 2012 included approximately $2.3 million of direct study costs related to our recently completed Phase II trial of CH-4051
and $3.4 million for Study 306B and our extension studies for Northera. Additionally, we incurred costs during the first six months
of 2012 related to medical affairs activities, including a team of medical science liaison professionals, hired on a contract
basis, generating costs of $0.8 million. We also incurred approximately $1.2 million of expenses for the purchase of active pharmaceutical
ingredient in January 2012 to be used in the manufacture of commercial product, formulation activities and the costs of distributing
clinical trial material. During 2011, primary expenditures were associated with the manufacturing of and process validation for
commercial drug product, our Northera QTc study, our Phase III and extension studies for Neurogenic OH, our Phase II trial of
droxidopa in fibromyalgia, our Phase II trial of CH-4051, medical affairs activities including medical science liaison contractors
and the costs of manufacturing, packaging and labeling clinical trial material for these trials. As a percentage of operating
expenses, excluding the impact of the restructuring, research and development costs were 53% for 2012 and 74% for 2011 reflecting
the overall decrease in our clinical research and development activities during the period.



Droxidopa.From inception
through December 31, 2012, we had spent approximately $117 million in research and development expenses on droxidopa. Research
and development costs for the Northera Neurogenic OH core program include our Phase III trial, Study 306B, our access and safety
program, Study 304, continuing regulatory activity and drug manufacture. We expect to spend approximately $0.5 million to complete
the final closing items for Study 306B and our extension program for Neurogenic OH patients in 2013. Currently, we can provide
no guidance around the costs of required new trials, if any, which may be necessary for the advancement of our Northera NDA as
the design of such a trial, or trials, has not been determined.



39







Antifolates.From inception
through December 31, 2012, we had spent approximately $43 million in research and development expenses on our portfolio of antifolates.
In May 2012, we announced the top-line results of our completed Phase II trial of CH-4051 in patients with rheumatoid arthritis.
Results of this trial indicated that CH-4051 did not demonstrate superior efficacy to methotrexate in the dose range evaluated.
While we believe that higher doses of CH-4051 might provide enhanced therapeutic benefit in rheumatoid arthritis and that CH-4051
could be developed for other anti-inflammatory and autoimmune indications, we determined that current resources would be better
allocated toward the completion of our Northera development program in Neurogenic OH. Although we continue to evaluate potential
partnering opportunities for these compounds we currently have no immediate plans to continue the development of CH-4051.



I-3D Portfolio.From
inception through December 31, 2012, we had spent approximately $2.5 million in research and development expenses on the I-3D
portfolio of compounds. We have conducted compound discovery work on the portfolio to try and identify one or more lead compounds.
All of the work completed to date was performed before 2008 and we do not expect to incur significant additional expenses for
these compounds until we identify a partner or obtain additional financing.



Sales and marketing expenses. Although
we had no formalized selling activities in either 2011 or 2012, sales and marketing expenses decreased by $0.8 million during
2012 when compared to 2011. During late 2011 and early 2012, we spent considerable resources on supporting the development and
implementation of sales and marketing initiatives for Northera in anticipation of a 2012 commercial launch. During the second
quarter of 2012, the majority of costs were related to bringing such activities to a close, cancelling related vendor contracts
and finalizing projects that were in progress upon receipt of the CRL in March 2012. Such activities included market research,
sales force strategy and planning, planning and development of advertising and promotional campaigns, website development, sales
operations, sales support systems implementations, employee training programs, sales force recruiting and public relations. At
the beginning of the third quarter of 2012, we announced a restructuring and concurrent reduction in force which essentially eliminated
all sales and marketing positions that had been filled in anticipation of commercialization. As such, overall expenses for the
second half of 2012 decreased significantly. Sales and marketing expenses for the six months ended June 30, 2012 were approximately
$6.7 million leaving only $0.5 million of expenses recognized in the second half of 2012. During 2011, primary expenditures were
related to the initiation of the commercialization activities outlined above as well as compensation and related expenses, travel
costs and legal expenses related to our intellectual property.



General and administrative expenses.
During 2012 general and administrative expenses increased by approximately $0.4 million when compared to 2011. Contributing to
this increase were increases in professional fees, including legal and investor relations costs, insurance, financial printing
and bank fees.



Restructuring expense.In July 2012,
we initiated a corporate restructuring under which the number of employees was significantly reduced, retaining only those employees
necessary to continue supporting our efforts to obtain marketing approval for Northera in the United States. This reduction in
force primarily, but not exclusively, impacted those positions that had been filled in 2011 and 2012 to support the planned commercialization
of Northera in the United States. In addition, our Chief Executive Officer and our Vice President of Sales and Marketing resigned.
At the Board level, the Chairman of the Board stepped down, but remains a director while another existing director assumed the
role of Chairman. The former CEO and two other directors also resigned from the Board. Costs related to these activities, consisting
primarily of severance payments, were recorded in 2012 and totaled approximately $2.2 million.



Interest income and interest expense.
At December 31, 2012, we had cash and cash equivalents of $28.4 million. The decrease in interest income in 2012 compared to 2011
is primarily related to our decreased cash position and continued low interest rates in the United States.



40







Comparison of Years ended December 31, 2011 and 2010



(in thousands, except percentages)

|                                   |  | For the      |        |  | For the      |   |        |            |  |   |        |  
|---------------------------------- |  | ------------ | ------ |  | ------------ | - | ------ | ---------- |  | - | ------ | -
|                                   |  | year ended   |        |  | year ended   |   |        | $          |  |   |        |  
|                                   |  | December 31, |        |  | December 31, |   |        | Increase   |  |   | %      |  
|                                   |  | 2011         |        |  | 2010         |   |        | (Decrease) |  |   | Change |  
|Research and development expense   |  | $            | 37,270 |  |              | $ | 30,871 |            |  | $ | 6,399  |  
|Sales and marketing expense        |  |              | 8,068  |  |              |   | 2,476  |            |  |   | 5,592  |  
|General and administrative expense |  |              | 5,276  |  |              |   | 4,155  |            |  |   | 1,121  |  
|Interest income                    |  |              | 162    |  |              |   | 243    |            |  |   | (81    | )
|Interest expense                   |  |              | -      |  |              |   | (70    | )          |  |   | 70     |  



Research and development expenses. In
2011, we incurred costs for Study 306A, Study 306B and our open-label extension study, Study 304 for Northera. We also incurred
expenses for a Phase II trial of our antifolate, CH-4051, in rheumatoid arthritis for which enrollment was initiated in September
2010. In 2010, we completed our second pivotal Phase III trial in Neurogenic OH, Study 301, and initiated Study 306. Also, during
2011, we had costs for the preparation and filing of our NDA for Northera. Specifically, 2011 expenses included approximately
$2.7 million related to the preparation and filing of our NDA, $5.2 million related to our ongoing Phase II trial of CH4051, $7.0
million related to Study 306 and $3.5 million for our Northera extension studies. Additionally, we incurred costs during the period
related to medical affairs activities related to the planned launch of Northera, including hiring, on a contract basis, a team
of Medical Science Liaison professionals, generating costs of $1.4 million. We also incurred expenses for the purchase and validation
of active pharmaceutical ingredient to be used in the manufacture of commercial product, expenses for our Phase II trial of droxidopa
in fibromyalgia and the costs of manufacturing, packaging, labeling and distributing clinical trial material. During 2010, primary
expenditures were associated with our Phase III studies of Northera in Neurogenic OH, including extension studies, our Phase II
trial of droxidopa in fibromyalgia and initial costs related to our Phase II trial of our antifolates in rheumatoid arthritis.
Also contributing to our expenses in both periods were compensation and related costs. As a percentage of operating expenses,
research and development costs were 74% for 2011 and 82% for 2010.



Sales and marketing expenses. Although
we had no formalized selling activities, during the year ended December 31, 2011 sales and marketing expenses increased significantly
when compared to 2010. A significant component of this increase was related to increased compensation and related costs as we
added personnel with the appropriate expertise in this area to support the anticipated commercialization of Northera. In addition,
we also began to see an expected ramp up in the costs of developing and implementing our sales and marketing initiatives for Northera
during that period. Such costs included market research, sales force strategy and planning, planning for advertising and promotional
campaigns, website development, sales operations planning, employee training programs and public relations. In addition, we also
had increases in travel costs, promotional costs that include conference sponsorships and legal expenses related to our intellectual
property. During 2010, primary expenditures were related to compensation and related expenses and legal expenses related to our
intellectual property.



General and administrative expenses.
During 2011, general and administrative expenses increased by approximately $1.1 million when compared to 2010. Contributing to
this increase were increases in compensation and related costs, primarily for stock-based compensation, professional fees, including
audit, tax and legal fees, rent expense, related to the expansion of our headquarters office space, financial printing, depreciation,
taxes/government fees and transfer agent fees.



Interest income and interest expense.
At December 31, 2011, we had cash and cash equivalents of $41.1 million and short-term investments of $4.5 million. The decrease
in interest income is primarily related to the loss of interest income on auction rate securities, or ARS, investments that were
fully liquidated by June 30, 2010 but that paid premium interest rates during the first six months of 2010 combined with continued
low interest rates in the United States. Interest expense decreased as the line of credit associated with our investments in ARS
held at UBS was fully paid on June 30, 2010.



Liquidity and Capital Resources



From inception to December 31, 2012, we
have incurred an aggregate net loss of approximately $215.1 million as a result of expenses similar in nature to those described
above.



41







As of December 31, 2012, we had working
capital of approximately $25.8 million including cash and cash equivalents of approximately $28.4 million and current liabilities
of $3.0 million. We have financed our operations primarily through sales of our stock and, to a much lesser extent, through the
issuance of our common stock pursuant to option or warrant exercises. Cash on hand results primarily from previous financing activities
offset by funds utilized for operating and investing activities. Our financing activities are more fully described in “Financings”
below.



We invest our cash in a variety of financial
instruments in order to preserve principal and liquidity while seeking reasonable returns. To limit market risk, investments are
restricted to high quality instruments with relatively short maturities including, but not limited to, fully liquid interest-bearing
money market accounts, commercial paper, certificates of deposit, money market funds and Treasury funds typically with a maturity
of six months or less.



During 2011, we held short-term investments
in certificates of deposit, or CDs, with maturities of 26 weeks or less as of the date of purchase. These investments were purchased
through the Certificate of Deposit Account Registry Service, or CDARS®. Investments are made through a single CDARS
Network member and when a large deposit is made, that institution uses the CDARS service to place funds into CDs issued by other
members of the CDARS Network. Investments occur in increments below the standard Federal Deposit Insurance Corporation, or FDIC,
insurance maximum ($250,000) so that both principal and interest are eligible for FDIC insurance. During 2012, the last of these
short-term investments in CDs matured and was fully redeemed.



General



We have incurred negative cash flows from
operations since inception. We have spent, and expect to continue to spend, substantial amounts in connection with implementing
our business strategy, including our planned product development efforts, our clinical trials and our efforts to secure FDA approval
for Northera and evaluate opportunities for possible strategic alliances.



Given the reduced expenses that are being realized
from our restructuring initiative and the reduced level of clinical activity as of December 31, 2012, we believe that capital
resources available at that date will be sufficient to meet our operating needs into the third quarter of 2014. Our estimate assumes
the planned costs of currently ongoing clinical activity and a planned new trial of Northera that could begin patient dosing as
early as the fourth quarter of 2013 with a significant ramp in spending in the third quarter of 2013. In addition to the initial
costs of a new clinical trial, this revised guidance assumes various costs related to the resubmission of the Northera NDA. No
material additional activity related to, or subsequent to, a possible approval of Northera, nor to the commercialization of Northera
should it be approved, has been included in this guidance. We anticipate that the new clinical trial for Northera that is currently
estimated to commence dosing in the fourth quarter of 2013 will not be completed until at least 2015 and therefore we do not expect
current cash reserves to be adequate to complete the study. Should additional clinical and or regulatory activities arise, costs
related to those activities could adversely impact our estimate.



From inception through December 31, 2012
we had losses of $215.1 million. We had net losses of $31.7 million, $50.5 million and $37.3 million for the years ended December
31, 2012, 2011 and 2010, respectively, and we anticipate losses at least through 2013 and into 2014 unless we should successfully
negotiate a strategic agreement earlier that might include out-licensing, co-development or co-promotion of one or more of our
drug candidates. Actual losses will depend on a number of considerations including:



| | · | the
                                                                                                              timing of our resubmission
                                                                                                              of the Northera
                                                                                                              NDA to the FDA;
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | continuing discussions
                                                                                                              with regulatory
                                                                                                              agencies concerning
                                                                                                              the design and timing
                                                                                                              of new clinical
                                                                                                              trials and safety
                                                                                                              monitoring programs;
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | possible out-licensing
                                                                                                              of our product candidates;
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | continuing discussions
                                                                                                              with regulatory
                                                                                                              agencies concerning
                                                                                                              the requirements
                                                                                                              for and design of
                                                                                                              our clinical trials
                                                                                                              and safety monitoring
                                                                                                              programs;
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | the pace and
                                                                                                              success of development
                                                                                                              activities, including
                                                                                                              programs for droxidopa,
                                                                                                              antifolates and
                                                                                                              other product candidates;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | our ability
                                                                                                              to identify and
                                                                                                              recruit patients
                                                                                                              into our clinical
                                                                                                              trials at costs
                                                                                                              consistent with
                                                                                                              our current estimates;
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | seeking regulatory
                                                                                                              approval for our
                                                                                                              various product
                                                                                                              candidates, particularly
                                                                                                              our NDA for Northera;
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



42







| | · | the pace of
                                                                                                              development of new
                                                                                                              intellectual property
                                                                                                              for our existing
                                                                                                              product candidates;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | in-licensing
                                                                                                              and development
                                                                                                              of additional product
                                                                                                              candidates; and
| | - | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | changes to staffing
                                                                                                              levels.
| | - | -----------------------------------------------------------------------------------------------------------------------------------------



Should we raise additional funds by selling
shares of common stock or other securities convertible into common stock, the ownership interest of our existing stockholders
will be diluted. If we are not able to obtain financing when needed, we may be required to delay, reduce the scope of, or eliminate
one or more of our development programs or curtail operations. As a result, our business, financial condition and results of operations
would be materially harmed.



Financings



2012 Shelf Registration Statement



In November 2012, the Company filed the
required documents and became eligible to use an at-the-market common equity sales program for the sale of shares of our common
stock up to a value of $20,000,000. These shares would be offered pursuant to the Company’s 2012 shelf registration statement.
As of December 31, 2012, no sales have been made under this program.



On February 8, 2012, the Company filed
with the Securities and Exchange Commission, or SEC, an amendment to its shelf registration statement on Form S-3 that was originally
filed on January 26, 2012, under which the Company may offer shares of its common stock and preferred stock, various series of
debt securities and/or warrants to purchase any of such securities, either individually or in units, in one or more offerings,
up to a total dollar amount of $100,000,000. Such registration statement, as amended, became effective as of February 9, 2012.



2011 Shelf Registration Statement



In January 2012, we raised gross proceeds
of approximately $23.7 million through the sale of 4,989,275 shares of our common stock in a publicly-marketed offering. These
shares were offered pursuant to our shelf registration statement, amended pursuant to Rule 462(b), as filed with the SEC, under
which we could offer shares of common stock and preferred stock, various series of debt securities and/or warrants to purchase
any of such securities, either individually or in units, in one or more offerings, up to a total dollar amount of $63,950,000.
The registration statement, as amended, became effective as of January 19, 2011. In connection with this offering, we paid commissions
and other offering-related costs of approximately $1.6 million, resulting in net proceeds of approximately $22.1 million.



In February 2011, we raised gross proceeds
of approximately $40.3 million through the sale of 10,062,500 shares of our common stock in a publicly-marketed offering. These
shares were offered pursuant to our 2011 shelf registration statement. In connection with this offering, we paid commissions and
other offering-related costs of approximately $2.5 million, resulting in net proceeds of approximately $37.8 million.



There are no more securities available
under the 2011 shelf registration statement.



2009 Shelf Registration Statement



In October 2010, we raised gross proceeds
of approximately $40.3 million through the sale of 8,214,286 shares of common stock in a publicly-marketed offering pursuant to
our shelf registration statement, as amended pursuant to Rule 462(b), as filed with the SEC under which we could offer shares
of our common stock and preferred stock, various series of debt securities and/or warrants to purchase any of such securities,
either individually or in units, in one or more offerings, up to a total dollar amount of $61,566,686. Such registration statement
became effective as of August 20, 2009. In connection with this offering, we paid commissions and other offering-related costs
of approximately $2.5 million.



In July 2010, we filed the required documents
and became eligible to use an at-the-market common equity sales program for the sale of up to 3,000,000 shares of common stock
pursuant to our 2009 shelf registration statement. In September 2010, we sold 634,500 shares of common stock under this program
resulting in net proceeds, after expenses for the program, of approximately $2.9 million.



43







On March 5, 2010, we raised gross proceeds
of approximately $18.2 million through the sale of 6,700,000 shares of common stock plus warrants for the purchase of 2,345,000
shares of common stock. These warrants had an aggregate fair value of approximately $3.9 million, permit the holders to purchase
the underlying common shares at $2.79 each or elect a net share settlement and are exercisable in whole at any time, or in part
from time to time, during the period commencing six months after the date of issuance and ending three years from the date of
issuance. These shares were offered pursuant to our 2009 shelf registration statement. In connection with this offering, we paid
commissions and other offering-related costs of approximately $1.5 million.



There are no more securities available
under the 2009 shelf registration statement.



2007 Shelf Registration Statement



On July 28, 2009, we raised gross proceeds
of approximately $13.3 million through the sale of 3,325,000 shares of common stock. These shares were offered pursuant to our
shelf registration statement filed with the SEC that became effective October 11, 2007, as amended pursuant to Rule 462(b), effective
July 22, 2009, to increase the dollar amount of securities available for sale, as filed with the SEC under which we could offer
shares of common stock and preferred stock, various series of debt securities and/or warrants to purchase any of such securities,
either individually or in units, in one or more offerings, up to a total dollar amount of $62,218,060. In connection with the
July 2009 offering, we received net proceeds, after deducting placement fees and offering expenses, of approximately $12.4 million.



On November 8, 2007, we raised gross proceeds
of approximately $48.9 million through the sale of 7,388,172 shares of our common stock in a registered direct offering. These
shares were offered pursuant to our 2007 shelf registration statement as filed with the SEC, under which we were able to offer
shares of our common stock and preferred stock, various series of debt securities and/or warrants to purchase any of such securities,
either individually or in units, in one or more offerings, up to a total dollar amount of $60.0 million, prior to its amendment.
Such registration statement became effective as of October 11, 2007. In connection with this offering, we paid commissions and
other offering-related costs of approximately $3.2 million.



There are no more securities available
under the 2007 shelf registration statement.



Private Placements



On March 22, 2007, we raised gross proceeds
of approximately $12.5 million through the private placement of 2,648,306 shares of our common stock plus warrants for the purchase
of 794,492 shares of our common stock. The aggregate fair value of these warrants was approximately $1.3 million. The warrants
permit the holders to purchase the underlying common shares at $5.66 each and are exercisable in whole at any time, or in part
from time to time, for cash, for five years from the date of issuance. The warrants are redeemable at par value at our option
in the event that the volume weighted-average closing price of our common stock is greater than $12.00 per share for any 20 consecutive
trading days provided we give 60 business days’ written notice to the holders and simultaneously
call all warrants on the same terms. Under the terms of the placement agreement, we agreed to and filed a registration
statement with the SEC within 30 days of the closing for the shares of common stock sold and the shares of common stock underlying
the warrants and such registration became effective on August 7, 2007. In connection with this offering, we paid commissions and
other offering-related costs of approximately $1.0 million in cash.



On February 13, 2006, we raised gross proceeds
of approximately $21.5 million through the private placement of 7,166,666 shares of our common stock plus warrants for the purchase
of 2,149,999 shares of our common stock. The aggregate fair value of these warrants was approximately $1.1 million. The warrants
permitted the holders to purchase the underlying common shares at $4.20 each and were exercisable in whole at any time, or in
part from time to time, for cash, for five years from the date of issuance. In addition, these warrants were redeemable at our
option in the event that the volume weighted average closing bid price of our common stock for any 20 consecutive trading days
is at least $9.00 per share. In connection with this offering, we paid commissions and other offering-related costs of approximately
$1.6 million in cash and issued warrants to the placement agent for the purchase of 716,666 shares of our common stock with an
exercise price of $3.30 per share, or 110% of the price of the shares sold in the offering and an aggregate fair value of approximately
$0.7 million. These warrants are exercisable in whole at any time, or in part from time to time, for cash or in a net share settlement,
for seven years from the date of issuance. Under the terms of the financing, we filed a registration statement with the SEC within
30 days of the closing for the shares of common stock sold and the shares of common stock underlying the warrants and such registration
became effective on March 29, 2006.



44







In December 2004, we raised gross proceeds
of approximately $14.5 million through the private placement of 5,532,994 shares of our common stock. The amount raised included
the conversion of a $1.7 million stockholder loan along with accrued interest, for which a total of 677,919 shares of common stock
were issued. In connection with this offering, we paid commissions and other offering-related costs of approximately $1.0 million
in cash and issued warrants to the placement agent for the purchase of 483,701 shares of our common stock with an aggregate fair
value of approximately $14,000. The warrants permit the holders to purchase the underlying common shares at $2.88 per share, and
are exercisable in whole at any time, or in part from time to time, for cash or in a net share settlement, for seven years from
the date of issuance.



License Agreement and Development Agreement Obligations



In March 2004, we entered into a License
Agreement with Dr. M. Gopal Nair, Ph.D., of the University of South Alabama College of Medicine, for rights to use, produce, distribute
and market products derived from an invention by Dr. Nair, claimed in US Patent # 5,912,251, entitled “metabolically inert
anti-inflammatory and antitumor antifolates”, designated by us as CH-1504 and related compounds. The license provides us
exclusive, worldwide (excluding India) rights for these compounds.



In 2004, as consideration for these rights,
we paid $150,000 and issued Dr. Nair and his designees 471,816 shares of common stock at an estimated aggregate value of $402.
As additional consideration, we agreed to pay to Dr. Nair and or his designees: (1) royalties on the sales should any compounds
be approved for commercial sale; (2) milestone payments, payable upon achievement of clinical milestones; and (3) payments to
be made on specified anniversary dates, some of which were payable in equity, at our discretion. There are no minimum royalties
under the agreement. We made milestone payments as required by the agreement of $100,000 each in March 2006 and 2005. In April
2007, we issued 26,643 shares of our common stock, subject to trading restrictions, at a value of approximately $5.63 per share,
in settlement of the $150,000 annual milestone payment for 2007. In March 2008, we made a milestone payment of $100,000 related
to patient dosing in a Phase II study as required by the agreement. In April 2008, we issued 30,612 shares of common stock, subject
to trading restrictions, at a value of approximately $4.90 per share, in settlement of the 2008 anniversary milestone payment
of $150,000. In April 2009, we made the 2009 anniversary milestone payment of $150,000. In October 2010, we made a milestone payment
of $100,000 related to patient dosing in a Phase II study as required by the agreement. We are also obligated to make future potential
milestone payments based on the achievement of specific development and regulatory approval milestones. Although we currently
have no ongoing clinical activity for this portfolio of molecules, approximately $1.5 million of payments may potentially become
due if specific clinical and regulatory milestones are achieved, subject to our right to terminate the license agreement. In addition,
should we enter into an out-licensing agreement, such payments could be offset by revenue received from the sub-licensee.



The license agreement includes certain
other covenants, which require us to, among other things, maintain and prosecute patents related to the license; use commercially
reasonable best efforts to bring the licensed product to market as soon as reasonably practicable and continue active, diligent
marketing efforts; and prepare and provide to the licensor certain reports concerning our development and commercialization efforts.
In the event we fail to carry out our responsibilities under the license agreement, the licensors may terminate the license. We
may elect to abandon the maintenance and prosecution of any patent applications or issued patents and we retain the right to terminate
the license agreement in whole or as to any portion by providing written notice of such intentions to the licensor. The license
agreement may also be terminated in the event we fail to make a scheduled milestone or royalty payment, we otherwise materially
breach the license agreement, or if we become involved in a bankruptcy, insolvency or similar proceeding, provided that we are
entitled to notice of such intention to terminate and an opportunity to cure. Regardless, the license agreement shall expire concurrent
with the date of the last to expire claim contained in the patent rights.



45







In May 2006, we entered into an agreement
with Dainippon Sumitomo Pharma Co., Ltd., or DSP, for a worldwide, exclusive, sub-licensable license and rights to certain intellectual
property and proprietary information relating to droxidopa including, but not limited to all information, formulations, materials,
data, drawings, sketches, designs, testing and test results, records and regulatory documentation. As consideration for these
rights, we paid DSP $100,000 and issued 63,131 shares of our common stock, with a value of approximately $4.35 per share, or $274,621.
As additional consideration, we agreed to pay DSP and or its designees: (1) royalties on the sales should any compound be approved
for commercial sale; and (2) milestone payments, payable upon achievement of milestones as defined in the agreement. In January
2007, we received notification that the FDA had granted orphan drug designation for droxidopa for the treatment of symptomatic
neurogenic orthostatic hypotension. Based on the terms of the DSP agreement, the granting of orphan drug designation for droxidopa
triggered a milestone payment to DSP of $250,000. We made such payment in February 2007. In February 2008, we made a milestone
payment under the agreement of $500,000 related to patient dosing in a Phase III study. In September 2011, we filed our NDA with
the FDA seeking approval to market Northera in the United States, triggering a milestone payment to DSP of $750,000. We made such
payment in December 2011. At December 31, 2012, remaining potential future milestone payments, subject to our right to terminate
the license agreement, totaled $2.5 million, including $1.5 million payable upon FDA approval.



Subsequent to execution of the agreement,
we agreed that DSP would initiate, and we would fund, activities focused on modifying the manufacturing capabilities of DSP in
order to expand capacity and comply with cGMP regulations and all existing manufacturing requirements of the FDA. Based on work
performed by DSP as of December 31, 2012, we had recorded cumulative expense of approximately $3.1 million.



In May 2006, we entered into a development
and commercialization agreement with Active Biotech AB to co-develop and commercialize the I-3D portfolio of orally active, dihydroorotate
dehydrogenase (DHODH) inhibiting compounds for the treatment of autoimmune diseases and transplant rejection. Under the terms
of the development agreement, an initial payment of $1.0 million was made to Active Biotech during 2006 with such funds utilized
to cover the initial costs of research and development efforts jointly approved by both parties. At December 31, 2006, we had
expensed the entire $1.0 million payment. At December 31, 2007, we had expensed cumulative costs of $1.0 million under the program,
in excess of the initial payment of $1.0 million, related to costs of research and development. During 2008, we ceased joint discovery
efforts with Active Biotech on this portfolio and, accordingly, recorded no costs related to this program during 2011, 2010 or
2009. In April 2008, we entered into a termination and assignment agreement with Active Biotech, whereby Active Biotech discontinued
its participation in the I-3D co-development program and assigned its entire right, title and interest in the portfolio to us
in exchange for royalties on future sales. The termination agreement also eliminated our obligation related to payment of potential
future development milestones under the development agreement.



Current and Future Financing Needs



We have incurred negative cash flow from
operations since inception. We have spent, and expect to continue to spend, substantial amounts in connection with implementing
our business strategy, including our planned product development efforts, our clinical trials, our research and discovery efforts
and our regulatory activities. Based on capital resources available at December 31, 2012, we believe that we have sufficient capital
resources to meet our operating needs into the third quarter of 2014. Potential sources of additional liquidity include strategic
relationships, out-licensing of our products, public or private sales of equity or debt, warrant and/or option exercises and other
sources. We might seek to access the public or private equity markets again when and if conditions are favorable. However, it
is uncertain whether additional funding will be available when we need it on terms that will be acceptable to us, or at all. If
we raise funds by selling additional shares of common stock or other securities convertible into common stock, the ownership interest
of our existing stockholders will be diluted. If we are not able to obtain financing when needed, we might be unable to carry
out our business plan. As a result, we might have to significantly delay certain activities or limit our operations and our business,
financial condition and results of operations would be materially harmed.



Off-Balance Sheet Arrangements



We do not have any unconsolidated entities,
and accordingly, we have not entered into any transactions with unconsolidated entities whereby we have financial guarantees,
subordinated retained interests, derivative instruments or other contingent arrangements that expose us to material continuing
risks, contingent liabilities, or any other obligations under a variable interest in an unconsolidated entity that provides us
with financing, liquidity, market risk or credit risk support.



46







Contractual Obligations and Commitments



As of December 31, 2012, we have known
contractual obligations and commitments of approximately $2.9 million, primarily related to contracted research and development
and regulatory activities for Northera and our office lease. To facilitate an understanding of our
contractual obligations and commercial commitments, the following data is provided as of December 31, 2012:



|                            |  | Payments due by period |          
|--------------------------- |  | ---------------------- | ---------
|                            |  |                        |          
|Category                    |  | Total                  |          
|Operating lease obligations |  | $                      | 1,214,571
|Purchase obligations        |  |                        | 1,706,963
|                            |  |                        |          
|Total                       |  | $                      | 2,921,534



We have also entered into certain other
agreements that, based on our future development and commercialization plans as of December 31, 2012, might require us to make
contingent milestone payments of up to approximately $4 million over the life of the agreements upon the achievement of certain
clinical or commercial milestones. Such future payments are subject to our right to terminate the agreements. In the event that
the milestones are not achieved, we elect not to pursue further testing of the drug candidate or we terminate such agreements,
we will have no further obligations under the agreements. The uncertainty relating to the timing and occurrence of the commitments
described prevents us from including them in the table above.



Critical Accounting Policies



Our management’s discussion and analysis
of our financial condition and results of operations is based on our financial statements, which have been prepared in accordance
with accounting principles generally accepted in the United States of America. Our significant accounting policies are more fully
described in Note 1 to the consolidated financial statements included in this Annual Report on Form 10-K. The following accounting
policies are critical in fully understanding and evaluating our reported financial results.



Use of Estimates



The preparation of financial statements in conformity with
accounting principles generally accepted in the United States of America requires management to make estimates and assumptions
that affect the reported amounts of assets and liabilities and the disclosure of contingent liabilities at the date of the financial
statements as well as the reported revenue and expenses during the reporting periods. On an ongoing basis, management evaluates
its estimates and judgments. Management bases estimates on historical experience and on various other factors that it believes
are reasonable under the circumstances, the results of which form the basis for making judgments about the carrying value of assets
and liabilities that are not readily apparent from other sources. Actual results might differ from these estimates under different
assumptions or conditions. We consider an accounting estimate to be critical if the accounting estimate
requires us to make assumptions about matters that were uncertain at the time the accounting estimate was made and where changes
in the estimate that could occur from period to period, or use of different reasonable estimates in the current period, would
have a material impact on our financial condition or results of operations.



Significant estimates and assumptions are required related
to the estimated costs and estimated percentages of completion of research and development activities that are outsourced to third-party
contractors, the valuation of assets and stock-based compensation. Some of these judgments can be subjective and complex, and,
consequently, actual results may differ from these estimates. For any given individual estimate or assumption made by us, there
may also be other estimates or assumptions that are reasonable. Although we believe that our estimates and assumptions are reasonable,
they are based upon information available at the time the estimates and assumptions were made. Actual results may differ significantly
from our estimates.



Research and Development



Research and development expenditures are expensed based upon
our most recent estimate of the costs to complete these activities. We often contract with third parties contract research organizations,
or CROs, to facilitate, coordinate and perform agreed upon research and development activities.  Expense recognition is based
upon estimated percentage of completion at the financial statement date applied against estimated amounts to complete the project.
Estimates are calculated, maintained and presented by the CROs and are then subjected to rigorous periodic internal review and
analysis to ensure reasonableness of the estimates. Such review includes difficult, subjective and complex judgments, particularly
in instances of studying orphan drug candidates where prior clinical activity is limited, providing little or no historical cost
information. Given the highly variable nature of the costs involved in the completion of a clinical or pre-clinical trial, fluctuations
in costs estimates can occur at any time during the trial or at its conclusion based on a number of factors including, but not
limited to, the rate at which investigator sites are identified, the site locations (US versus International), the timing of site
activation, the rate at which patients are enrolled into a trial, changes to the number of sites and/or patients that are targeted
for the trial, the timelines for trial completion and changes in scope of the actions to be taken by the contractor.



47







Given that the recognition of expense related to our contracted
research and development activities comprise a significant component of our reported expenses during any given period, such fluctuations
can be material to our results of operations and the carrying value of assets and liabilities. The estimates to complete each
contracted project are also used in the determination and disclosure of contractual obligations providing a meaningful snapshot
of cash requirements arising from future contractual payment obligations based upon the best information available at the time
the financial statements are published.



To ensure that research and development costs are expensed
as incurred, we measure expense based on estimated work performed for the underlying contract, typically utilizing a percentage-of-completion
approach, and record prepaid assets or accrue expenses on a monthly basis for such activities based on the measurement of liability
from expense recognition and the receipt of invoices. Contracts for research and development programs typically call for the payment
of fees for services at the initiation of the contract and/or upon the achievement of certain milestones.  In the event that
we prepay fees for future milestones, we record the prepayment as a prepaid asset and amortize the asset into research and development
expense over the period of time the contracted research and development services are performed.  Most fees are incurred throughout
the contract period and are expensed based on their estimated percentage of completion at a particular date. Although such fees
may fluctuate during the life of a research and development program, such fluctuations are generally based on changes in or delays
in the timelines for study completion.



These contracts generally include pass through fees. 
Pass through fees include, but are not limited to, regulatory expenses, investigator fees, travel costs, and other miscellaneous
costs including shipping and printing fees.  Because these fees are incurred at various times during the contract term and
they are used throughout the contract term, we record a monthly expense allocation to recognize the fees during the contract period. 
Fees incurred to set up the clinical trial are expensed during the setup period. Estimating the costs of pass-through expenses
for a contracted research and development program can be difficult and complex. Judgments used in the development of these estimates
include the costs of our previous clinical trials, estimates of patient recruitment rates, estimates of drop-out rates and estimates
of site identification and activation rates. Estimates of investigator payments, lab costs, database development and management
and adverse event reporting are based on parameters such as number of office visits, laboratory requirements, screening failure
rates, location of the investigator site and the patient related factors discussed above. Historically, we have experienced fluctuations
in the estimates of thee costs and have implemented rigorous review processes to ensure reliability of our estimates. Fluctuations
that have occurred previously have been in the range of +/- 5% of total program costs and we would anticipate that similar fluctuations
could occur in the future. Depending on the size of the trial, the estimated costs to complete and the volume of overall research
and development activities during any given period, such fluctuations could be material to our results of operations and financial
position.



We had contracted with a third-party
to manufacture commercial quantities of Northera prior to the date we anticipated that Northera would receive final regulatory
marketing approval and might perform similar activities with other product candidates in the future. The scale-up and commercial
production of pre-launch inventories involves the risk that such products may not be approved for marketing by the appropriate
regulatory agencies on a timely basis, or ever. As such, until final approval to market any our product candidates is received
from the appropriate regulatory agencies, such costs are expensed to research and development.



Costs related to the acquisition of technology rights and patents
for which development work is still in process are expensed as incurred and considered a component of research and development
costs.



48







Accounting for Stock-Based Compensation



We account for our stock options utilizing the fair value based
method of accounting for stock options or similar equity instruments. In determining the fair value of the equity instrument,
we consider, among other factors, (i) the risk-free interest rate, (ii) the expected life of the options granted, (iii) the anticipated
dividend yield, (iv) the estimated future volatility of the underlying shares and (v) anticipated future forfeitures. To determine
the risk-free interest rate, we utilize the U.S. Treasury yield curve in effect at the time of grant with a term consistent with
the expected life of our awards. We estimate the expected life of the options granted based on anticipated exercises in future
periods assuming the success of our business model as currently forecasted. The expected dividends reflect our current and expected
future policy for dividends on our common stock. To determine the expected stock price volatility for our stock options, we analyze
the historical volatility of our stock price over a period equal to the expected life of the options. We plan to continue to analyze
the expected stock price volatility and expected term assumption at each grant date.



As of January 1, 2011, taking into consideration hiring completed
and planned by us and the potential impact of forfeitures given the roles of these newly filled positions, we estimated a forfeiture
rate of 3%. Given the events of 2012 and the corporate restructuring announced in July 2012 that have negatively impacted our
staffing levels, the estimated forfeiture rate was changed to 24% for the first six months of 2012 and the impact of this change
in estimate was recognized as a cumulative catch-up and serves to reduce the stock-based compensation costs for the quarter ended
June 30, 2012. In July 2012, we again reviewed our estimated forfeiture rate, based upon the adjusted staffing levels resulting
from the corporate restructuring and, effective at that date, modified our estimated forfeiture rate to 11.5%. In periods prior
to 2011, our rate of forfeiture was immaterial to the recognition of compensation expense for options.



Our results of operations include non-cash compensation expense
as a result of the issuance of stock option grants utilizing this method. We expect to record additional non-cash compensation
expense in the future, which might be significant. Due to the limited amount of historical data available to us, particularly
with respect to stock-price volatility, employee exercise patterns and forfeitures, actual results could differ from our assumptions.



| | ITEM 7A. | QUANTITATIVE
                                                                                         AND QUALITATIVE DISCLOSURES ABOUT MARKET
                                                                                         RISK.
| | -------- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



We invest our cash in a variety of financial
instruments in order to preserve principal and liquidity while maximizing returns and we do not invest in financial instruments
or their derivatives for trading or speculative purposes. To minimize the exposure due to adverse shifts in interest rates, we
maintain investments of shorter maturities. Our investment guidelines include security type, credit quality and maturity and are
intended to limit market risk by restricting our investments to high quality debt instruments with relatively short maturities.
A portion of our cash is maintained in non-interest bearing accounts at federally insured financial institutions that, under the
Transaction Account Guarantee Program of the Federal Deposit Insurance Corporation, or FDIC, were fully insured until December
31, 2012. In addition, we maintained and continue to maintain funds on deposit in commercial accounts that include non-interest
bearing commercial checking accounts, fully liquid interest-bearing money market accounts, money market funds and Treasury funds
typically with maturities of six months or less. All deposits and investments to date have been made in U. S. dollars and, accordingly,
have no exposure to foreign currency rate fluctuations on these investments. Our interest income is sensitive to changes in the
general level of interest rates in the United States, particularly since our monetary assets are maintained in accounts with immediate
liquidity or with short-term maturities. Currently, the returns on such liquid, short-term investments are at historic lows. Accordingly,
we estimate that any sensitivity experienced due to fluctuations of interest rates in the United States for such investments would
have no material impact on our consolidated financial position or results of operations.



| | ITEM 8. | FINANCIAL
                                                                                        STATEMENTS AND SUPPLEMENTARY DATA.
| | ------- | ------------------------------------------------------------------------------------------------------------------------------------



(a) The financial statements required to
be filed pursuant to this Item 8 are appended to this Annual Report on Form 10-K. An index of the financial statements filed herewith
is found on page 54.



49







(b)          The
unaudited quarterly financial data for the two-year period ended December 31, 2012 is as follows:



|                                         |  | Year ended December
    31, 2011 |            
|---------------------------------------- |  | -------------------------------- | -----------
|                                         |  | First                            |            
|                                         |  | Quarter                          |            
|Operating expenses                       |  | $                                | 13,902,789 
|Loss from operations                     |  |                                  | (13,902,789
|Other income (expense)                   |  |                                  | 34,582     
|Net loss                                 |  |                                  | (13,868,207
|Basic and diluted net loss per share (a) |  |                                  | (0.25      



|                                         |  | Year ended December 31, 2012 |            
|---------------------------------------- |  | ---------------------------- | -----------
|                                         |  | First                        |            
|                                         |  | Quarter                      |            
|Operating expenses                       |  | $                            | 15,587,992 
|Loss from operations                     |  |                              | (15,587,992
|Other income (expense)                   |  |                              | 28,774     
|Net loss                                 |  |                              | (15,559,218
|Basic and diluted net loss per share (a) |  |                              | (0.23      



| | (a) | Basic and diluted net loss per share for each of the quarters
                                                                presented above is based on the respective weighted average number
                                                                of common shares for the quarters. As such, the sum of the quarters
                                                                may not necessarily be equal to the full year loss per share amount.
                                                                Basic and diluted net loss per share are identical since potentially
                                                                dilutive securities are excluded from the calculations, as the
                                                                effect would be anti-dilutive for all periods presented.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |     |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
| | (b) | The fourth quarter of 2012 reflects credit adjustments to research and development costs recorded during the period and
totaling approximately $1.4 million, or $0.02 per share (see Note 6 to the financial statements appended to this Annual Report
on Form 10-K). These adjustments are related to changes in estimates to complete certain clinical programs based on new information
obtained during the fourth quarter.                                                                                                                                                                                                                                                                                                                                                                                                                                        



| | ITEM 9. | CHANGES
                                                                                        IN AND DISAGREEMENTS WITH ACCOUNTANTS
                                                                                        ON ACCOUNTING AND FINANCIAL DISCLOSURE.
| | ------- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



None.



| | ITEM 9A. | CONTROLS
                                                                                         AND PROCEDURES.
| | -------- | -----------------------------------------------------------------------------------------------------------------



Disclosure Controls and Procedures



Disclosure controls and procedures as defined
in Rule 13a-15(e) under the Securities Exchange Act of 1934, or the Exchange Act, are designed only to provide reasonable assurance
that they will meet their objectives that information required to be disclosed in our Exchange Act reports is recorded, processed,
summarized and reported within the time periods specified in the SEC’s rules and forms, and that such information is accumulated
and communicated to our management, including our Chief Executive Officer and Chief Financial Officer, as appropriate, to allow
timely decisions regarding required disclosures.  As of the end of the period covered by this report, we carried out an evaluation,
under the supervision and with the participation of our management, including our Chief Executive Officer and Chief Financial
Officer, of the effectiveness of the design and operation of our disclosure controls and procedures (as defined in Rule 13a-15(e))
pursuant to Exchange Act Rule 13a-15.  Based upon that evaluation and subject to the foregoing, our Chief Executive Officer
and Chief Financial Officer have concluded that our disclosure controls and procedures were effective as of December 31, 2012.



Changes in Internal Control over Financial Reporting



Management has determined that, as of December
31, 2012, there were no changes in our internal control over financial reporting that occurred during our fiscal quarter then
ended that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.



50







Management’s Report on Internal Control Over Financial
Reporting



Our management is responsible for establishing
and maintaining adequate internal control over financial reporting, as such term is defined in Rule 13a-15(f) under the Exchange
Act. Our internal control over financial reporting is designed to provide reasonable assurance regarding the reliability of financial
reporting and the preparation of financial statements for external purposes in accordance with accounting principles generally
accepted in the United States. However, all internal control systems, no matter how well designed, have inherent limitations.
Therefore, even those systems determined to be effective can provide only reasonable assurance with respect to financial statement
preparation and reporting.



Management assessed the effectiveness of
our internal control over financial reporting as of December 31, 2012. In making this assessment, management used the criteria
set forth by the Committee of the Sponsoring Organizations of the Treadway Commission (COSO) in Internal Control-Integrated Framework
and the Guidance for Smaller Public Companies as published by COSO in June 2006. Based on that assessment, management believes
that we maintained effective internal control over financial reporting as of December 31, 2012, based on those criteria.



Ernst & Young LLP, our independent
registered public accounting firm, which has audited the financial statements included in Part IV, Item 15 of this report, has
also audited our internal control over financial reporting as of December 31, 2012, as stated in their report, which is included
below.



Report of Independent Registered Public
Accounting Firm on Internal Control over Financial Reporting



The Board
of Directors and Stockholders of

Chelsea
Therapeutics International, Ltd. and Subsidiary



We have audited Chelsea Therapeutics International,
Ltd. and Subsidiary’s internal control over financial reporting as of December 31, 2012, based on criteria established in
Internal Control—Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (the
COSO criteria). Chelsea Therapeutics International, Ltd. and Subsidiary’s management is responsible for maintaining effective
internal control over financial reporting, and for its assessment of the effectiveness of internal control over financial reporting
included in the accompanying Management’s Report on Internal Control over Financial Reporting. Our responsibility is to
express an opinion on the Company’s internal control over financial reporting based on our audit.



We conducted our audit in accordance with
the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform
the audit to obtain reasonable assurance about whether effective internal control over financial reporting was maintained in all
material respects. Our audit included obtaining an understanding of internal control over financial reporting, assessing the risk
that a material weakness exists, testing and evaluating the design and operating effectiveness of internal control based on the
assessed risk, and performing such other procedures as we considered necessary in the circumstances. We believe that our audit
provides a reasonable basis for our opinion.



A company’s internal control over financial
reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation
of financial statements for external purposes in accordance with generally accepted accounting principles. A company’s internal
control over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in
reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the company; (2) provide reasonable
assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally
accepted accounting principles, and that receipts and expenditures of the company are being made only in accordance with authorizations
of management and directors of the company; and (3) provide reasonable assurance regarding prevention or timely detection of unauthorized
acquisition, use or disposition of the company’s assets that could have a material effect on the financial statements.



Because of its inherent limitations, internal
control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness
to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree
of compliance with the policies or procedures may deteriorate.



51







In our opinion, Chelsea Therapeutics International,
Ltd. and Subsidiary maintained, in all material respects, effective internal control over financial reporting as of December 31,
2012, based on the COSO criteria.



We also have audited, in accordance with
the standards of the Public Company Accounting Oversight Board (United States), the consolidated balance sheets of Chelsea Therapeutics
International, Ltd. and Subsidiary (a development stage company) as of December 31, 2012 and 2011, and the related consolidated
statements of operations, changes in stockholders' equity, and cash flows for each of the three years in the period ended December
31, 2012, and for the period from April 3, 2002 (inception) through December 31, 2012 of Chelsea Therapeutics International, Ltd.
and Subsidiary and our report dated March 7, 2013 expressed an unqualified opinion thereon.



/s/ Ernst & Young LLP

Raleigh, North Carolina

March 7, 2013



| | ITEM 9B. | OTHER
                                                                                                                                INFORMATION.
| | -------- | --------------------------------------------------------------------------------------------------------------------------------------------------



Not applicable.



52







PART III



| | ITEM 10. | DIRECTORS,
                                                                                                                                EXECUTIVE
                                                                                                                                OFFICERS
                                                                                                                                AND
                                                                                                                                CORPORATE
                                                                                                                                GOVERNANCE.
| | -------- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Incorporated by reference from the information
under the headings “Proposal One – Election of Directors” and “Section 16(a) Beneficial Ownership Reporting
Compliance” in our proxy statement for the 2013 Annual Meeting of Stockholders, which we will file with the SEC within 120 days
of the end of the fiscal year to which this report relates.



| | ITEM 11. | EXECUTIVE
                                                                                         COMPENSATION.
| | -------- | ----------------------------------------------------------------------------------------------------------------



Incorporated by reference from the information
under the headings “Executive Compensation and Other Matters” in our proxy statement for the 2013 Annual Meeting of
Stockholders, which we will file with the SEC within 120 days of the end of the fiscal year to which this report relates.



| | ITEM 12. | SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND
MANAGEMENT AND RELATED STOCKHOLDER MATTERS.
| | -------- | -----------------------------------------------------------------------------------------------



Incorporated by reference from the information
under the headings “Security Ownership of Certain Beneficial Owners and Management” and “Equity Compensation
Plan Information” in our proxy statement for the 2013 Annual Meeting of Stockholders, which we will file with the SEC within
120 days of the end of the fiscal year to which this report relates.



| | ITEM 13. | CERTAIN RELATIONSHIPS
AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE.
| | -------- | --------------------------------------------------------------------------



Incorporated by reference from the information
under the headings “Certain Transactions with Related Persons”, “Proposal One – Election of Directors”
and “Corporate Governance Matters” in our proxy statement for the 2013 Annual Meeting of Stockholders, which we will
file with the SEC within 120 days of the end of the fiscal year to which this report relates.



| | ITEM 14. | PRINCIPAL
                                                                                         ACCOUNTING FEES AND SERVICES
| | -------- | -------------------------------------------------------------------------------------------------------------------------------



Incorporated by reference from the information
under the heading “Audit Committee Report” in our proxy statement for the 2013 Annual Meeting of Stockholders, which
we will file with the SEC within 120 days of the end of the fiscal year to which this report relates.



53







PART IV



| | ITEM 15. | EXHIBITS
                                                                                         AND FINANCIAL STATEMENTS
| | -------- | --------------------------------------------------------------------------------------------------------------------------



| | (a) | Financial Statements.
| | --- | ---------------------

The following statements are filed as
part of this report:



| |                                                            | Page
| | ---------------------------------------------------------- | ----
| |                                                            |     
| | Reports of Independent Registered Public Accounting Firms. | F-1 
| | Consolidated Balance Sheets                                | F-3 
| | Consolidated Statements of Operations                      | F-4 
| | Consolidated Statements of Stockholders' Equity            | F-5 
| | Consolidated Statements of Cash Flows                      | F-10
| | Notes to Consolidated Financial Statements.                | F-12



Schedules not listed above have been omitted
because the information required to be set forth therein is not applicable or is shown in the financial statements or notes thereto.



| | (b) | Exhibits.
| | --- | ---------



|ExhibitNumber |  | Description of Document                                                                                                                                                                          |  | Registrant’sForm |  | Dated    |  | ExhibitNumber |  | FiledHerewith
|------------- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ |  | ---------------- |  | -------- |  | ------------- |  | -------------
|              |  |                                                                                                                                                                                                  |  |                  |  |          |  |               |  |              
|1.1           |  | Placement Agency Agreement dated November 1, 2007 by and among
    Chelsea Therapeutics International, Ltd., Leerink Swann LLC, Oppenheimer & Co. Inc. and Punk Ziegel & Company.                |  | 8-K              |  | 11/02/07 |  | 1.1           |  |              
|              |  |                                                                                                                                                                                                  |  |                  |  |          |  |               |  |              
|1.2           |  | Placement Agency Agreement dated July 22, 2009 by and among
    Chelsea Therapeutics International, Ltd., Wedbush Morgan Securities, Inc. and Ladenburg Thalmann & Co. Inc.                      |  | 8-K              |  | 07/23/09 |  | 1.1           |  |              
|              |  |                                                                                                                                                                                                  |  |                  |  |          |  |               |  |              
|1.3           |  | Placement Agency Agreement dated February 26, 2010 by and among
    the Company, Leerink Swann LLC and Needham & Company, LLC.                                                                   |  | 8-K              |  | 02/26/10 |  | 1.1           |  |              
|              |  |                                                                                                                                                                                                  |  |                  |  |          |  |               |  |              
|1.4           |  | Equity Underwriting Agreement, dated October 1, 2010,
        between Chelsea Therapeutics International, Ltd. and Deutsche Bank Securities Inc., as representative of the several underwriters. |  | 8-K              |  | 10/01/10 |  | 1.2           |  |              
|              |  |                                                                                                                                                                                                  |  |                  |  |          |  |               |  |              
|1.5           |  | Equity Underwriting Agreement, dated February 18, 2011, between
    Chelsea Therapeutics International, Ltd. and Deutsche Bank Securities Inc., as representative of the several underwriters.   |  | 8-K              |  | 02/18/11 |  | 1.3           |  |              
|              |  |                                                                                                                                                                                                  |  |                  |  |          |  |               |  |              
|2.1           |  | Agreement and Plan of Merger by and among Ivory Capital Corporation,
    Chelsea Therapeutics, Inc. and Chelsea Acquisition Corp, dated as of January 17, 2005.                                  |  | 8-K+             |  | 01/21/05 |  | 2.1           |  |              
|              |  |                                                                                                                                                                                                  |  |                  |  |          |  |               |  |              
|2.2           |  | Agreement and Plan of Merger between Ivory Capital Corporation
    and Chelsea Therapeutics International, Ltd., dated as of June 17, 2005.                                                      |  | 14A+             |  | 07/28/05 |  | Appendix A    |  |              
|              |  |                                                                                                                                                                                                  |  |                  |  |          |  |               |  |              
|3.1           |  | Certificate of Incorporation for Chelsea Therapeutics International,
    Ltd., as amended on June 1, 2010                                                                                        |  | 10-Q             |  | 11/01/11 |  | 3.1           |  |              



54







|ExhibitNumber |  | Description of Document                                                                                                                                                                 |  | Registrant’sForm |  | Dated    |  | ExhibitNumber |  | FiledHerewith
|------------- |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ---------------- |  | -------- |  | ------------- |  | -------------
|              |  |                                                                                                                                                                                         |  |                  |  |          |  |               |  |              
|3.2           |  | Bylaws of Chelsea Therapeutics International, Ltd.                                                                                                                                      |  | S-1/A            |  | 08/18/05 |  | 3.2           |  |              
|              |  |                                                                                                                                                                                         |  |                  |  |          |  |               |  |              
|4.1           |  | Form of Registered Direct Warrant issued to investors on March
    5, 2010.                                                                                                             |  | 8-K              |  | 02/26/10 |  | 4.1           |  |              
|              |  |                                                                                                                                                                                         |  |                  |  |          |  |               |  |              
|10.1*         |  | License Agreement dated as of March 24, 2004 between M. Gopal
    Nair and Chelsea Therapeutics, Inc. (f/k/a Aspen Therapeutics, Inc.)                                                  |  | 8-K+             |  | 02/16/05 |  | 10.1          |  |              
|              |  |                                                                                                                                                                                         |  |                  |  |          |  |               |  |              
|10.2          |  | Form of Subscription Agreement for the purchase of Series A
    Convertible Preferred Stock of Chelsea Therapeutics, Inc.                                                               |  | 8-K+             |  | 02/16/05 |  | 10.3          |  |              
|              |  |                                                                                                                                                                                         |  |                  |  |          |  |               |  |              
|10.3          |  | Chelsea Therapeutics International, Ltd. 2004 Stock Plan, as
    amended, and forms of Notice of Stock Option Grant and Stock Option Agreement, as amended January 25, 2012.            |  | 10-K             |  | 03/07/12 |  | 10.3          |  |              
|              |  |                                                                                                                                                                                         |  |                  |  |          |  |               |  |              
|10.4          |  | Form of Subscription Agreement and Warrant for the purchase
    of common stock, par value $0.0001 per share, of Chelsea Therapeutics International, Ltd.                               |  | 8-K              |  | 02/17/06 |  | 10.5          |  |              
|              |  |                                                                                                                                                                                         |  |                  |  |          |  |               |  |              
|10.5          |  | Placement Agency Agreement dated November 28, 2005 between Chelsea
    Therapeutics International, Ltd. and Paramount BioCapital, Inc.                                                  |  | 10-K             |  | 03/08/06 |  | 10.6          |  |              
|              |  |                                                                                                                                                                                         |  |                  |  |          |  |               |  |              
|10.6          |  | Employment Agreement between Chelsea Therapeutics International,
    Ltd. and Dr. Simon Pedder, dated March 2, 2012.                                                                    |  | 10-K             |  | 03/07/12 |  | 10.6          |  |              
|              |  |                                                                                                                                                                                         |  |                  |  |          |  |               |  |              
|10.7*         |  | Development and Commercialization Agreement dated as of May
    5, 2006 between Active Biotech AB and Chelsea Therapeutics International, Ltd.                                          |  | 10-Q             |  | 08/14/06 |  | 10.8          |  |              
|              |  |                                                                                                                                                                                         |  |                  |  |          |  |               |  |              
|10.8*         |  | Exclusive License Agreement effective May 26, 2006 between Dainippon
    Sumitomo Pharma Co., Ltd. and Chelsea Therapeutics, Inc.                                                       |  | 10-Q             |  | 08/14/06 |  | 10.9          |  |              
|              |  |                                                                                                                                                                                         |  |                  |  |          |  |               |  |              
|10.9*         |  | Finder’s Agreement dated May 26, 2006 between Paramount
    BioCapital, Inc. and Chelsea Therapeutics International, Ltd.                                                               |  | 10-Q             |  | 08/14/06 |  | 10.10         |  |              
|              |  |                                                                                                                                                                                         |  |                  |  |          |  |               |  |              
|10.10         |  | Form of Subscription Agreement for the purchase of common stock
    of Chelsea Therapeutics International, Ltd. dated March 19, 2007 and related form of Warrant, dated March 22, 2007. |  | 8-K              |  | 03/20/07 |  | 10.11         |  |              
|              |  |                                                                                                                                                                                         |  |                  |  |          |  |               |  |              
|10.13         |  | Form of Subscription Agreement for the purchase of common stock
    and warrants to purchase common stock of Chelsea Therapeutics International, Ltd.                                   |  | 8-K              |  | 02/26/10 |  | 10.15         |  |              
|              |  |                                                                                                                                                                                         |  |                  |  |          |  |               |  |              
|10.14         |  | Sales Agreement, dated July 2, 2010, between Chelsea Therapeutics,
    Ltd. and Cantor Fitzgerald & Co.                                                                                 |  | S-3              |  | 01/10/11 |  | 10.16         |  |              



55









|ExhibitNumber |  | Description of Document                                                                                                                                                                                                |  | Registrant’sForm |  | Dated    |  | ExhibitNumber |  | FiledHerewith
|------------- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ---------------- |  | -------- |  | ------------- |  | -------------
|              |  |                                                                                                                                                                                                                        |  |                  |  |          |  |               |  |              
|10.15         |  | Amendment No. 1, dated July 26, 2011, to Sales Agreement, dated
    July 2, 2010, between Chelsea Therapeutics International, Ltd. and Cantor Fitzgerald & Co.                                                         |  | 8-K              |  | 07/26/11 |  | 10.15         |  |              
|              |  |                                                                                                                                                                                                                        |  |                  |  |          |  |               |  |              
|10.16         |  | Amendment No. 2, dated December 28, 2011, to Sales Agreement,
    dated July 2, 2010, as amended July 26, 2011, between Chelsea Therapeutics International, Ltd. and Cantor Fitzgerald &
    Co.                       |  | 8-K              |  | 12/29/11 |  | 10.16         |  |              
|              |  |                                                                                                                                                                                                                        |  |                  |  |          |  |               |  |              
|10.17*        |  | Manufacturing Services Agreement, dated November 7, 2011, between
    Chelsea Therapeutics, Inc. and Patheon Inc.                                                                                                      |  | 10-K             |  | 03/07/12 |  | 10.17         |  |              
|              |  |                                                                                                                                                                                                                        |  |                  |  |          |  |               |  |              
|10.18         |  | Severance and Release Agreement, dated as of July 9, 2012, between
    Chelsea Therapeutics International, Ltd. And Dr. Simon Pedder                                                                                   |  | 8-K              |  | 07/13/12 |  | 10.17         |  |              
|              |  |                                                                                                                                                                                                                        |  |                  |  |          |  |               |  |              
|10.19         |  | Severance Agreement, dates as of October 16, 2012, between Chelsea
    Therapeutics International, Ltd. And Joseph Oliveto                                                                                             |  | 8-K              |  | 10/16/12 |  | 10.19         |  |              
|              |  |                                                                                                                                                                                                                        |  |                  |  |          |  |               |  |              
|10.20         |  | Amendment No. 3, dated November 26, 2012, to Sales Agreement,
    dated July 2, 2010, as amended July 26, 2011 and December 28, 2011, between Chelsea Therapeutics International, Ltd. and Cantor
    Fitzgerald & Co. |  | 8-K              |  | 11/26/12 |  | 10.20         |  |              
|              |  |                                                                                                                                                                                                                        |  |                  |  |          |  |               |  |              
|21.1          |  | Subsidiaries of Chelsea Therapeutics International, Ltd.                                                                                                                                                               |  | 10-K             |  | 03/12/07 |  | 21.1          |  |              
|              |  |                                                                                                                                                                                                                        |  |                  |  |          |  |               |  |              
|23.1          |  | Consent of Independent Registered Public Accounting Firm.                                                                                                                                                              |  | 10-K             |  | 03/07/13 |  | 23.1          |  |              
|              |  |                                                                                                                                                                                                                        |  |                  |  |          |  |               |  |              
|23.2          |  | Consent of Independent Registered Public Accounting Firm.                                                                                                                                                              |  | 10-K             |  | 03/07/13 |  | 23.2          |  |              
|              |  |                                                                                                                                                                                                                        |  |                  |  |          |  |               |  |              
|31.1          |  | Certification by the Chief Executive Officer pursuant to Section
    240.13a-14 or section 240.15d-14 of the Securities and Exchange Act of 1934, as amended.                                                          |  |                  |  |          |  |               |  | X            
|              |  |                                                                                                                                                                                                                        |  |                  |  |          |  |               |  |              
|31.2          |  | Certification by the Chief Financial Officer pursuant to Section 240.13a-14 or section 240.15d-14
    of the Securities and Exchange Act of 1934, as amended.                                                          |  |                  |  |          |  |               |  | X            
|              |  |                                                                                                                                                                                                                        |  |                  |  |          |  |               |  |              
|32.1          |  | Certification by the Chief Executive Officer pursuant to 18
    U.S.C. 1350 as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.                                                                      |  |                  |  |          |  |               |  | X            
|              |  |                                                                                                                                                                                                                        |  |                  |  |          |  |               |  |              
|32.2          |  | Certification by the Chief Financial Officer pursuant to 18
    U.S.C. 1350 as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.                                                                      |  |                  |  |          |  |               |  | X            
|              |  |                                                                                                                                                                                                                        |  |                  |  |          |  |               |  |              
|101           |  | Financials submitted in XBRL format.                                                                                                                                                                                   |  | 10-K             |  | 03/07/13 |  | 101           |  |              





* The registrant received confidential treatment with respect
to certain portions of this exhibit. Such portions have been omitted from this exhibit and have been filed separately with the
SEC.



+ Filed by Ivory Capital Corporation, predecessor in interest.



56







SIGNATURES



Pursuant to the requirements
of Section 13 or 15(d) of the Securities Exchange Act of 1934, as amended, the registrant
has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized this 14th day of
March 2013.



| | Chelsea Therapeutics
                                              International, Ltd.
| | --------------------------------------------------------------------------------------
| |                                                                                       
| | By:                                                                                   
| |                                                                                       



57







Report of Independent Registered Public
Accounting Firm



The Board of Directors and Stockholders of

Chelsea Therapeutics International, Ltd. and Subsidiary



We have audited the accompanying consolidated balance sheets
of Chelsea Therapeutics International, Ltd. and Subsidiary (a development stage company) as of December 31, 2012 and 2011, and
the related consolidated statements of operations, changes in stockholders' equity, and cash flows for each of the three years
in the period ended December 31, 2012, and for the period from April 3, 2002 (inception) through December 31, 2012.  These
financial statements are the responsibility of the Company's management.  Our responsibility is to express an opinion on
these financial statements based on our audits. The financial statements for the period from April 3, 2002 (inception) through
December 31, 2007, were audited by other auditors whose report dated March 10, 2008 expressed an unqualified opinion on those
statements. The financial statements for the period from April 3, 2002 (inception) through December 31, 2007 include total operating
expenses and net loss of $37,144,571 and $34,685,202, respectively.  Our opinion on the consolidated statements of operations,
changes in stockholders' equity, and cash flows for the period from April 3, 2002 (inception) through December 31, 2012, insofar
as it relates to amounts for prior periods through December 31, 2007, is based solely on the report of other auditors.



We conducted our audits in accordance with the standards of
the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain
reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on
a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the
accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement
presentation. We believe that our audits and the report of other auditors provide a reasonable basis for our opinion.



In our opinion, based on our audits and the report of other
auditors, the financial statements referred to above present fairly, in all material respects, the consolidated financial position
of Chelsea Therapeutics International, Ltd. and Subsidiary at December 31, 2012 and 2011, and the consolidated results of their
operations and their cash flows for each of the three years in the period ended December 31, 2012, and the period from April 3,
2002 (inception) through December 31, 2012, in conformity with U.S. generally accepted accounting principles.



We also have audited, in accordance with the standards of the
Public Company Accounting Oversight Board (United States), Chelsea Therapeutics International, Ltd. and Subsidiary’s internal
control over financial reporting as of December 31, 2012, based on criteria established in Internal Control-Integrated Framework
issued by the Committee of Sponsoring Organizations of the Treadway Commission and our report dated March 7, 2013 expressed an
unqualified opinion thereon.



/s/ Ernst & Young LLP

Raleigh, North Carolina

March 7, 2013



F-1







Report of Independent
Registered Public Accounting Firm



The Board of Directors and Stockholders

Chelsea Therapeutics International, Ltd.



We have audited the consolidated statements
of operations (not presented separately herein), changes in stockholders’ equity and cash flows (not presented separately
herein) of Chelsea Therapeutics International, Ltd. and Subsidiary (a development stage company) for the period from April 3,
2002 (inception) to December 31, 2007. These consolidated financial statements are the responsibility of the Company’s management.
Our responsibility is to express an opinion on these consolidated financial statements based on our audits.



We conducted our audits in accordance
with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and
perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An
audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit
also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the
overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.



In our opinion, the consolidated financial statements referred
to above present fairly, in all material respects, the results of operations and cash flows of Chelsea Therapeutics International,
Ltd. and Subsidiary for the period from April 3, 2002 (inception) to December 31, 2007, in conformity with accounting principles
generally accepted in the United States of America.



/s/ CohnReznick LLP



Roseland, New Jersey

March 10, 2008



F-2







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY
(A Development Stage Company)CONSOLIDATED BALANCE SHEETS



|                                                                                                                                             |  | December 31, |              |   | December 31, |  
|-------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------ | ------------ | - | ------------ | -
|                                                                                                                                             |  | 2012         |              |   | 2011         |  
|                                                                                                                                             |  |              |              |   |              |  
|Assets                                                                                                                                       |  |              |              |   |              |  
|Current assets:                                                                                                                              |  |              |              |   |              |  
|Cash and cash equivalents                                                                                                                    |  | $            | 28,424,631   |   |              | $
|Short-term investments, net                                                                                                                  |  |              | -            |   |              |  
|Prepaid contract research and manufacturing                                                                                                  |  |              | 175,192      |   |              |  
|Other prepaid expenses and other
    current assets                                                                                          |  |              | 176,181      |   |              |  
|Total current assets                                                                                                                         |  |              | 28,776,004   |   |              |  
|Property and equipment, net                                                                                                                  |  |              | 151,544      |   |              |  
|Other assets                                                                                                                                 |  |              | -            |   |              |  
|                                                                                                                                             |  | $            | 28,927,548   |   |              | $
|                                                                                                                                             |  |              |              |   |              |  
|Liabilities and Stockholders' Equity                                                                                                         |  |              |              |   |              |  
|Current liabilities:                                                                                                                         |  |              |              |   |              |  
|Accounts payable                                                                                                                             |  | $            | 788,073      |   |              | $
|Accrued compensation and related expenses                                                                                                    |  |              | 199,935      |   |              |  
|Accrued restructuring                                                                                                                        |  |              | 841,184      |   |              |  
|Accrued contract research and manufacturing                                                                                                  |  |              | 496,901      |   |              |  
|Other accrued expenses                                                                                                                       |  |              | 685,305      |   |              |  
|Total current liabilities                                                                                                                    |  |              | 3,011,398    |   |              |  
|Commitments                                                                                                                                  |  |              |              |   |              |  
|Stockholders' equity:                                                                                                                        |  |              |              |   |              |  
|Preferred stock, $0.0001 par value, 5,000,000 shares
    authorized, no shares issued and outstanding                                        |  |              | -            |   |              |  
|Common stock, $0.0001 par value, 100,000,000 shares
    authorized and 67,075,779 and 62,034,146 shares issued and outstanding, respectively |  |              | 6,708        |   |              |  
|Additional paid-in capital                                                                                                                   |  |              | 240,970,852  |   |              |  
|Deficit accumulated during the
    development stage                                                                                         |  |              | (215,061,410 | ) |              |  
|Total stockholders' equity                                                                                                                   |  |              | 25,916,150   |   |              |  
|                                                                                                                                             |  | $            | 28,927,548   |   |              | $



See accompanying
notes to consolidated financial statements.



F-3







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY
(A Development Stage Company)CONSOLIDATED STATEMENTS OF OPERATIONS



|                                                                           |  |                                      |             |   |                     |   |             | Period from   | 
|-------------------------------------------------------------------------- |  | ------------------------------------ | ----------- | - | ------------------- | - | ----------- | ------------- | 
|                                                                           |  |                                      |             |   |                     |   |             | April 3, 2002 | 
|                                                                           |  | For the years ended December
    31, |             |   | (inception) through |  
|                                                                           |  | 2012                                 |             |   | 2011                |   |             | 2010          | 
|                                                                           |  |                                      |             |   |                     |   |             |               | 
|Operating expenses:                                                        |  |                                      |             |   |                     |   |             |               | 
|Research and development                                                   |  | $                                    | 16,744,423  |   |                     | $ | 37,270,138  |               | 
|Sales and marketing                                                        |  |                                      | 7,221,800   |   |                     |   | 8,067,709   |               | 
|General and administrative                                                 |  |                                      | 5,679,485   |   |                     |   | 5,276,146   |               | 
|Restructuring                                                              |  |                                      | 2,157,795   |   |                     |   | -           |               | 
|Total operating expenses                                                   |  |                                      | 31,803,503  |   |                     |   | 50,613,993  |               | 
|                                                                           |  |                                      |             |   |                     |   |             |               | 
|Operating loss                                                             |  |                                      | (31,803,503 | ) |                     |   | (50,613,993 | )             | 
|Interest income                                                            |  |                                      | 67,594      |   |                     |   | 161,828     |               | 
|Interest expense                                                           |  |                                      | -           |   |                     |   | -           |               | 
|                                                                           |  |                                      |             |   |                     |   |             |               | 
|Net loss                                                                   |  | $                                    | (31,735,909 | ) |                     | $ | (50,452,165 | )             | 
|                                                                           |  |                                      |             |   |                     |   |             |               | 
|Net loss per basic and diluted
    share of common stock                   |  | $                                    | (0.47       | ) |                     | $ | (0.84       | )             | 
|                                                                           |  |                                      |             |   |                     |   |             |               | 
|Weighted average number of basic
    and diluted common shares outstanding |  |                                      | 66,892,982  |   |                     |   | 60,136,326  |               | 





See accompanying notes to consolidated
financial statements.



F-4







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



CONSOLIDATED STATEMENTS OF CHANGES IN
STOCKHOLDERS’ EQUITY

|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   |              |   |  | Deferred    |        |   | Deficit     |   |         |        | 
|--------------------------------------------------------------------------------------------------------------------------------------- |  | ------------ | ---------- |  | ------- | - | ----- | ---------- |  | - | ------------ | - |  | ----------- | ------ | - | ----------- | - | ------- | ------ | 
|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   | Unpaid       |   |  | stock-      |        |   | accumulated |   |         | Total  | 
|                                                                                                                                        |  |              |            |  |         |   |       | Additional |  |   | Subscription |   |  | based       |        |   | during the  |   |         | stock- | 
|                                                                                                                                        |  | Common stock |            |  | Paid-In |   |       | on common  |  |   | compen-      |   |  | development |        |   | holders'    |  
|                                                                                                                                        |  | Shares       |            |  | Amount  |   |       | Capital    |  |   | stock        |   |  | sation      |        |   | stage       |   |         | equity | 
|Issuance of common stock to founders in April 2002                                                                                      |  |              | 5,428,217  |  |         | $ | 542   |            |  | $ | 4,083        |   |  | $           | (4,625 | ) |             | $ | -       |        | 
|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   |              |   |  |             |        |   |             |   |         |        | 
|Balance at December 31, 2003                                                                                                            |  |              | 5,428,217  |  |         |   | 542   |            |  |   | 4,083        |   |  |             | (4,625 | ) |             |   | -       |        | 
|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   |              |   |  |             |        |   |             |   |         |        | 
|Common stock issued in March 2004, at approximately $0.0009 per share, for license fee                                                  |  |              | 471,816    |  |         |   | 47    |            |  |   | 355          |   |  |             | -      |   |             |   | -       |        | 
|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   |              |   |  |             |        |   |             |   |         |        | 
|Sale and issuance of common stock in April 2004, at approximately $0.0009 per share to chief
    executive                              |  |              | 478,330    |  |         |   | 48    |            |  |   | 360          |   |  |             | -      |   |             |   | -       |        | 
|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   |              |   |  |             |        |   |             |   |         |        | 
|Receipt of cash for stock subscription receivable                                                                                       |  |              | -          |  |         |   | -     |            |  |   | -            |   |  |             | 4,625  |   |             |   | -       |        | 
|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   |              |   |  |             |        |   |             |   |         |        | 
|Sale and issuance of common stock in December 2004 at approximately $2.45 per share, net of issuance
    costs                          |  |              | 5,532,994  |  |         |   | 554   |            |  |   | 13,550,255   |   |  |             | -      |   |             |   | -       |        | 
|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   |              |   |  |             |        |   |             |   |         |        | 
|Deferred stock-based compensation                                                                                                       |  |              | -          |  |         |   | -     |            |  |   | 33,525       |   |  |             | -      |   |             |   | (33,525 | )      | 
|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   |              |   |  |             |        |   |             |   |         |        | 
|Amortization of deferred stock- based compensation                                                                                      |  |              | -          |  |         |   | -     |            |  |   | -            |   |  |             | -      |   |             |   | 1,529   |        | 
|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   |              |   |  |             |        |   |             |   |         |        | 
|Net loss                                                                                                                                |  |              | -          |  |         |   | -     |            |  |   | -            |   |  |             | -      |   |             |   | -       |        | 
|Balance at December 31, 2004                                                                                                            |  |              | 11,911,357 |  |         |   | 1,191 |            |  |   | 13,588,578   |   |  |             | -      |   |             |   | (31,996 | )      | 
|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   |              |   |  |             |        |   |             |   |         |        | 
|Recapitalization of the                                                                                                                 |  |              |            |  |         |   |       |            |  |   |              |   |  |             |        |   |             |   |         |        | 
|Company (See Note 1)                                                                                                                    |  |              | 457,168    |  |         |   | 46    |            |  |   | (400,046     | ) |  |             | -      |   |             |   | -       |        | 
|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   |              |   |  |             |        |   |             |   |         |        | 
|Employee stock options exercised                                                                                                        |  |              | 14,663     |  |         |   | 1     |            |  |   | 998          |   |  |             | -      |   |             |   |         |        | 
|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   |              |   |  |             |        |   |             |   |         |        | 
|Adoption of SFAS 123R                                                                                                                   |  |              | -          |  |         |   | -     |            |  |   | (31,996      | ) |  |             | -      |   |             |   | 31,996  |        | 
|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   |              |   |  |             |        |   |             |   |         |        | 
|Amortization of deferred stock- based compensation                                                                                      |  |              | -          |  |         |   | -     |            |  |   | 99,319       |   |  |             | -      |   |             |   | -       |        | 
|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   |              |   |  |             |        |   |             |   |         |        | 
|Variable accounting for stock options granted to third party                                                                            |  |              | -          |  |         |   | -     |            |  |   | 58,594       |   |  |             | -      |   |             |   | -       |        | 
|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   |              |   |  |             |        |   |             |   |         |        | 
|Net loss                                                                                                                                |  |              | -          |  |         |   | -     |            |  |   | -            |   |  |             | -      |   |             |   | -       |        | 
|Balance at December 31, 2005                                                                                                            |  |              | 12,383,188 |  |         |   | 1,238 |            |  |   | 13,315,447   |   |  |             | -      |   |             |   | -       |        | 
|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   |              |   |  |             |        |   |             |   |         |        | 
|Sale and issuance of common stock with detachable warrants in February 2006 at approximately
    $2.77 per share, net of issuance costs |  |              | 7,166,666  |  |         |   | 717   |            |  |   | 19,854,935   |   |  |             | -      |   |             |   | -       |        | 
|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   |              |   |  |             |        |   |             |   |         |        | 
|Common stock issued in March 2006, at par, pursuant to net-share (cashless) exercise of common
    stock warrants                       |  |              | 15,461     |  |         |   | 2     |            |  |   | (2           | ) |  |             | -      |   |             |   | -       |        | 
|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   |              |   |  |             |        |   |             |   |         |        | 
|Common stock issued in May 2006, at approximately $4.35 per share, for license fee                                                      |  |              | 63,131     |  |         |   | 6     |            |  |   | 274,615      |   |  |             | -      |   |             |   | -       |        | 
|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   |              |   |  |             |        |   |             |   |         |        | 
|Employee stock options exercised                                                                                                        |  |              | 78,683     |  |         |   | 8     |            |  |   | 5,072        |   |  |             | -      |   |             |   | -       |        | 
|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   |              |   |  |             |        |   |             |   |         |        | 
|Stock-based compensation                                                                                                                |  |              | -          |  |         |   | -     |            |  |   | 283,983      |   |  |             | -      |   |             |   | -       |        | 
|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   |              |   |  |             |        |   |             |   |         |        | 
|Variable accounting for stock options granted to third party                                                                            |  |              | -          |  |         |   | -     |            |  |   | 4,192        |   |  |             | -      |   |             |   | -       |        | 
|                                                                                                                                        |  |              |            |  |         |   |       |            |  |   |              |   |  |             |        |   |             |   |         |        | 
|Net loss                                                                                                                                |  |              | -          |  |         |   | -     |            |  |   | -            |   |  |             | -      |   |             |   | -       |        | 
|Balance at December 31, 2006                                                                                                            |  |              | 19,707,129 |  |         |   | 1,971 |            |  |   | 33,738,242   |   |  |             | -      |   |             |   | -       |        | 



See accompanying notes to consolidated
financial statements.



F-5







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



CONSOLIDATED STATEMENTS OF CHANGES IN
STOCKHOLDERS’ EQUITY (continued)

|                                                                                                                                                                                          |  |              |            |  |         |  |       |            |  |  |              |   |  | Deferred    |   |  | Deficit     |  |   |        | 
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------ | ---------- |  | ------- |  | ----- | ---------- |  |  | ------------ | - |  | ----------- | - |  | ----------- |  | - | ------ | 
|                                                                                                                                                                                          |  |              |            |  |         |  |       |            |  |  | Unpaid       |   |  | stock-      |   |  | accumulated |  |   | Total  | 
|                                                                                                                                                                                          |  |              |            |  |         |  |       | Additional |  |  | Subscription |   |  | based       |   |  | during the  |  |   | stock- | 
|                                                                                                                                                                                          |  | Common stock |            |  | Paid-In |  |       | on common  |  |  | compen-      |   |  | development |   |  | holders'    | 
|                                                                                                                                                                                          |  | Shares       |            |  | Amount  |  |       | Capital    |  |  | stock        |   |  | sation      |   |  | stage       |  |   | equity | 
|Balance at December 31, 2006                                                                                                                                                              |  |              | 19,707,129 |  |         |  | 1,971 |            |  |  | 33,738,242   |   |  |             | - |  |             |  | - |        | 
|                                                                                                                                                                                          |  |              |            |  |         |  |       |            |  |  |              |   |  |             |   |  |             |  |   |        | 
|Common stock issued during 2007, at par, pursuant to net-share (cashless) exercises of common
    stock warrants                                                                          |  |              | 68,136     |  |         |  | 6     |            |  |  | (6           | ) |  |             | - |  |             |  | - |        | 
|                                                                                                                                                                                          |  |              |            |  |         |  |       |            |  |  |              |   |  |             |   |  |             |  |   |        | 
|Fair value of warrants issued in May 2006 in consideration of finders fee at approximately $1.75
    per share for which vesting was conditioned on an even that occurred in January 2007 |  |              | -          |  |         |  | -     |            |  |  | 433,750      |   |  |             | - |  |             |  | - |        | 
|                                                                                                                                                                                          |  |              |            |  |         |  |       |            |  |  |              |   |  |             |   |  |             |  |   |        | 
|Sale and issuance of common stock with detachable warrants in March 2007 at approximately $4.33
    per share, net of issuance costs                                                      |  |              | 2,648,306  |  |         |  | 265   |            |  |  | 11,476,412   |   |  |             | - |  |             |  | - |        | 
|                                                                                                                                                                                          |  |              |            |  |         |  |       |            |  |  |              |   |  |             |   |  |             |  |   |        | 
|Common stock issued in April 2007, at approximately $5.63 per share, for license fee                                                                                                      |  |              | 26,643     |  |         |  | 3     |            |  |  | 149,997      |   |  |             | - |  |             |  | - |        | 
|                                                                                                                                                                                          |  |              |            |  |         |  |       |            |  |  |              |   |  |             |   |  |             |  |   |        | 
|Common stock issued in June 2007, at $4.20 per share, pursuant to exercise of common stock warrants,
    net of fees                                                                      |  |              | 60,000     |  |         |  | 6     |            |  |  | 246,994      |   |  |             | - |  |             |  | - |        | 
|                                                                                                                                                                                          |  |              |            |  |         |  |       |            |  |  |              |   |  |             |   |  |             |  |   |        | 
|Common stock issued in October 2007, at $4.20 per share, pursuant to exercise of common stock
    warrants                                                                                |  |              | 1,200      |  |         |  | -     |            |  |  | 5,040        |   |  |             | - |  |             |  | - |        | 
|                                                                                                                                                                                          |  |              |            |  |         |  |       |            |  |  |              |   |  |             |   |  |             |  |   |        | 
|Sale and issuance of common stock in November 2007 at approximately $6.19 per share, net of issuance
    costs                                                                            |  |              | 7,388,172  |  |         |  | 739   |            |  |  | 45,754,030   |   |  |             | - |  |             |  | - |        | 
|                                                                                                                                                                                          |  |              |            |  |         |  |       |            |  |  |              |   |  |             |   |  |             |  |   |        | 
|Employee stock options exercised                                                                                                                                                          |  |              | 17,868     |  |         |  | 2     |            |  |  | 15,704       |   |  |             | - |  |             |  | - |        | 
|                                                                                                                                                                                          |  |              |            |  |         |  |       |            |  |  |              |   |  |             |   |  |             |  |   |        | 
|Stock-based compensation                                                                                                                                                                  |  |              | -          |  |         |  | -     |            |  |  | 828,626      |   |  |             | - |  |             |  | - |        | 
|                                                                                                                                                                                          |  |              |            |  |         |  |       |            |  |  |              |   |  |             |   |  |             |  |   |        | 
|Net loss                                                                                                                                                                                  |  |              | -          |  |         |  | -     |            |  |  | -            |   |  |             | - |  |             |  | - |        | 
|Balance at December 31, 2007                                                                                                                                                              |  |              | 29,917,454 |  |         |  | 2,992 |            |  |  | 92,648,789   |   |  |             | - |  |             |  | - |        | 



See accompanying notes to consolidated
financial statements.



F-6







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



CONSOLIDATED STATEMENTS OF CHANGES IN
STOCKHOLDERS’ EQUITY (continued)

|                                                                                                                                                           |  |              |            |  |         |  |       |            |  |  |              |   |  | Deferred    |   |  | Deficit     |  |   |        | 
|---------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------ | ---------- |  | ------- |  | ----- | ---------- |  |  | ------------ | - |  | ----------- | - |  | ----------- |  | - | ------ | 
|                                                                                                                                                           |  |              |            |  |         |  |       |            |  |  | Unpaid       |   |  | stock-      |   |  | accumulated |  |   | Total  | 
|                                                                                                                                                           |  |              |            |  |         |  |       | Additional |  |  | Subscription |   |  | based       |   |  | during the  |  |   | stock- | 
|                                                                                                                                                           |  | Common stock |            |  | Paid-In |  |       | on common  |  |  | compen-      |   |  | development |   |  | holders'    | 
|                                                                                                                                                           |  | Shares       |            |  | Amount  |  |       | Capital    |  |  | stock        |   |  | sation      |   |  | stage       |  |   | equity | 
|Balance at December 31, 2007                                                                                                                               |  |              | 29,917,454 |  |         |  | 2,992 |            |  |  | 92,648,789   |   |  |             | - |  |             |  | - |        | 
|                                                                                                                                                           |  |              |            |  |         |  |       |            |  |  |              |   |  |             |   |  |             |  |   |        | 
|Common stock issued during 2008, at par, pursuant to net-share (cashless) exercises of common
    stock warrants                                           |  |              | 57,983     |  |         |  | 6     |            |  |  | (6           | ) |  |             | - |  |             |  | - |        | 
|                                                                                                                                                           |  |              |            |  |         |  |       |            |  |  |              |   |  |             |   |  |             |  |   |        | 
|Common stock issued in 2008, at $4.20 per share, pursuant to exercise of common stock warrants                                                             |  |              | 11,200     |  |         |  | 1     |            |  |  | 47,039       |   |  |             | - |  |             |  | - |        | 
|                                                                                                                                                           |  |              |            |  |         |  |       |            |  |  |              |   |  |             |   |  |             |  |   |        | 
|Final adjustment to issuance costs accrued in conjunction with the sale and issuance of common
    stock in November 2007 at approximately $6.19 per share |  |              | -          |  |         |  | -     |            |  |  | 5,733        |   |  |             | - |  |             |  | - |        | 
|                                                                                                                                                           |  |              |            |  |         |  |       |            |  |  |              |   |  |             |   |  |             |  |   |        | 
|Common stock issued in April 2008, at approximately $4.90 per share, for license fee                                                                       |  |              | 30,612     |  |         |  | 3     |            |  |  | 149,997      |   |  |             | - |  |             |  | - |        | 
|                                                                                                                                                           |  |              |            |  |         |  |       |            |  |  |              |   |  |             |   |  |             |  |   |        | 
|Employee stock options exercised                                                                                                                           |  |              | 94,230     |  |         |  | 9     |            |  |  | 58,935       |   |  |             | - |  |             |  | - |        | 
|                                                                                                                                                           |  |              |            |  |         |  |       |            |  |  |              |   |  |             |   |  |             |  |   |        | 
|Stock-based compensation                                                                                                                                   |  |              | -          |  |         |  | -     |            |  |  | 1,405,752    |   |  |             | - |  |             |  | - |        | 
|                                                                                                                                                           |  |              |            |  |         |  |       |            |  |  |              |   |  |             |   |  |             |  |   |        | 
|Net loss                                                                                                                                                   |  |              | -          |  |         |  | -     |            |  |  | -            |   |  |             | - |  |             |  | - |        | 
|Balance at December 31, 2008                                                                                                                               |  |              | 30,111,479 |  |         |  | 3,011 |            |  |  | 94,316,239   |   |  |             | - |  |             |  | - |        | 
|                                                                                                                                                           |  |              |            |  |         |  |       |            |  |  |              |   |  |             |   |  |             |  |   |        | 
|Common stock issued during 2009, at par, pursuant to net-share (cashless) exercises of common
    stock warrants                                           |  |              | 63,927     |  |         |  | 6     |            |  |  | (6           | ) |  |             | - |  |             |  | - |        | 
|                                                                                                                                                           |  |              |            |  |         |  |       |            |  |  |              |   |  |             |   |  |             |  |   |        | 
|Sale and issuance of common stock in July 2009 at approximately $3.73 per share, net of issuance
    costs                                                 |  |              | 3,325,000  |  |         |  | 333   |            |  |  | 12,402,425   |   |  |             | - |  |             |  | - |        | 
|                                                                                                                                                           |  |              |            |  |         |  |       |            |  |  |              |   |  |             |   |  |             |  |   |        | 
|Stock-based compensation                                                                                                                                   |  |              | -          |  |         |  | -     |            |  |  | 1,673,165    |   |  |             | - |  |             |  | - |        | 
|                                                                                                                                                           |  |              |            |  |         |  |       |            |  |  |              |   |  |             |   |  |             |  |   |        | 
|Net loss                                                                                                                                                   |  |              | -          |  |         |  | -     |            |  |  | -            |   |  |             | - |  |             |  | - |        | 
|Balance at December 31, 2009                                                                                                                               |  |              | 33,500,406 |  |         |  | 3,350 |            |  |  | 108,391,823  |   |  |             | - |  |             |  | - |        | 



See accompanying notes to consolidated
financial statements.



F-7







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



CONSOLIDATED STATEMENTS OF CHANGES IN
STOCKHOLDERS’ EQUITY (continued)



|                                                                                                                                                            |  |              |            |  |         |   |       |            |  |   |              |   |  | Deferred    |   |  | Deficit     |   |   |        | 
|----------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------ | ---------- |  | ------- | - | ----- | ---------- |  | - | ------------ | - |  | ----------- | - |  | ----------- | - | - | ------ | 
|                                                                                                                                                            |  |              |            |  |         |   |       |            |  |   | Unpaid       |   |  | stock-      |   |  | accumulated |   |   | Total  | 
|                                                                                                                                                            |  |              |            |  |         |   |       | Additional |  |   | Subscription |   |  | based       |   |  | during the  |   |   | stock- | 
|                                                                                                                                                            |  | Common stock |            |  | Paid-In |   |       | on common  |  |   | compen-      |   |  | development |   |  | holders'    |  
|                                                                                                                                                            |  | Shares       |            |  | Amount  |   |       | Capital    |  |   | stock        |   |  | sation      |   |  | stage       |   |   | equity | 
|Balance at December 31, 2009                                                                                                                                |  |              | 33,500,406 |  |         |   | 3,350 |            |  |   | 108,391,823  |   |  |             | - |  |             |   | - |        | 
|                                                                                                                                                            |  |              |            |  |         |   |       |            |  |   |              |   |  |             |   |  |             |   |   |        | 
|Sale and issuance of common stock with detachable warrants in March 2010 at approximately $2.50
    per share, net of issuance costs                        |  |              | 6,700,000  |  |         |   | 670   |            |  |   | 16,762,253   |   |  |             | - |  |             |   | - |        | 
|                                                                                                                                                            |  |              |            |  |         |   |       |            |  |   |              |   |  |             |   |  |             |   |   |        | 
|Sale and issuance of common stock in controlled at-the-market equity offering in September 2010
    at approximately $4.49 per share, net of issuance costs |  |              | 634,500    |  |         |   | 63    |            |  |   | 2,851,313    |   |  |             | - |  |             |   | - |        | 
|                                                                                                                                                            |  |              |            |  |         |   |       |            |  |   |              |   |  |             |   |  |             |   |   |        | 
|Sale and issuance of common stock in in October 2010 at approximately $4.60 per share, net of
    issuance costs                                            |  |              | 8,214,286  |  |         |   | 821   |            |  |   | 37,788,721   |   |  |             | - |  |             |   | - |        | 
|                                                                                                                                                            |  |              |            |  |         |   |       |            |  |   |              |   |  |             |   |  |             |   |   |        | 
|Common stock issued in 2010 at par, pursuant to net-share (cashless) exercises of common stock
    warrants                                                 |  |              | 676,228    |  |         |   | 68    |            |  |   | (68          | ) |  |             | - |  |             |   | - |        | 
|                                                                                                                                                            |  |              |            |  |         |   |       |            |  |   |              |   |  |             |   |  |             |   |   |        | 
|Common stock issued in 2010 at $4.20 per share pursuant to exercise of common stock warrants                                                                |  |              | 65,555     |  |         |   | 7     |            |  |   | 275,324      |   |  |             | - |  |             |   | - |        | 
|                                                                                                                                                            |  |              |            |  |         |   |       |            |  |   |              |   |  |             |   |  |             |   |   |        | 
|Stock-based compensation                                                                                                                                    |  |              | -          |  |         |   | -     |            |  |   | 1,986,755    |   |  |             | - |  |             |   | - |        | 
|                                                                                                                                                            |  |              |            |  |         |   |       |            |  |   |              |   |  |             |   |  |             |   |   |        | 
|Net loss                                                                                                                                                    |  |              | -          |  |         |   | -     |            |  |   | -            |   |  |             | - |  |             |   | - |        | 
|                                                                                                                                                            |  |              |            |  |         |   |       |            |  |   |              |   |  |             |   |  |             |   |   |        | 
|Balance at December 31, 2010                                                                                                                                |  |              | 49,790,975 |  |         | $ | 4,979 |            |  | $ | 168,056,121  |   |  | $           | - |  |             | $ | - |        | 



See accompanying notes to consolidated
financial statements.



F-8







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



CONSOLIDATED STATEMENTS OF CHANGES IN
STOCKHOLDERS’ EQUITY (continued)



|                                                                                                               |  |              |            |  |         |   |       |            |  |   |              |   |  | Deferred    |   |  | Deficit     |   |   |        | 
|-------------------------------------------------------------------------------------------------------------- |  | ------------ | ---------- |  | ------- | - | ----- | ---------- |  | - | ------------ | - |  | ----------- | - |  | ----------- | - | - | ------ | 
|                                                                                                               |  |              |            |  |         |   |       |            |  |   | Unpaid       |   |  | stock-      |   |  | accumulated |   |   | Total  | 
|                                                                                                               |  |              |            |  |         |   |       | Additional |  |   | Subscription |   |  | based       |   |  | during the  |   |   | stock- | 
|                                                                                                               |  | Common stock |            |  | Paid-In |   |       | on common  |  |   | compen-      |   |  | development |   |  | holders'    |  
|                                                                                                               |  | Shares       |            |  | Amount  |   |       | Capital    |  |   | stock        |   |  | sation      |   |  | stage       |   |   | equity | 
|Balance at December 31, 2010                                                                                   |  |              | 49,790,975 |  |         |   | 4,979 |            |  |   | 168,056,121  |   |  |             | - |  |             |   | - |        | 
|                                                                                                               |  |              |            |  |         |   |       |            |  |   |              |   |  |             |   |  |             |   |   |        | 
|Sale and issuance of common stock in February 2011 at approximately $3.75 per share, net of issuance
    costs |  |              | 10,062,500 |  |         |   | 1,006 |            |  |   | 37,725,532   |   |  |             | - |  |             |   | - |        | 
|                                                                                                               |  |              |            |  |         |   |       |            |  |   |              |   |  |             |   |  |             |   |   |        | 
|Recovery of short-swing profits, net of expenses                                                               |  |              | -          |  |         |   | -     |            |  |   | 73,797       |   |  |             | - |  |             |   | - |        | 
|                                                                                                               |  |              |            |  |         |   |       |            |  |   |              |   |  |             |   |  |             |   |   |        | 
|Common stock issued in 2011 at $4.20 per share pursuant to cash exercises of common stock warrants             |  |              | 1,993,444  |  |         |   | 199   |            |  |   | 8,372,265    |   |  |             | - |  |             |   | - |        | 
|                                                                                                               |  |              |            |  |         |   |       |            |  |   |              |   |  |             |   |  |             |   |   |        | 
|Common stock issued in 2011 at $2.88 per share pursuant to cash exercises of common stock warrants             |  |              | 37,277     |  |         |   | 4     |            |  |   | 107,667      |   |  |             | - |  |             |   | - |        | 
|                                                                                                               |  |              |            |  |         |   |       |            |  |   |              |   |  |             |   |  |             |   |   |        | 
|Common stock issued in 2011 at par, pursuant to net-share (cashless) exercises of common stock
    warrants    |  |              | 149,950    |  |         |   | 15    |            |  |   | (15          | ) |  |             | - |  |             |   | - |        | 
|                                                                                                               |  |              |            |  |         |   |       |            |  |   |              |   |  |             |   |  |             |   |   |        | 
|Stock-based compensation                                                                                       |  |              | -          |  |         |   | -     |            |  |   | 2,648,741    |   |  |             | - |  |             |   | - |        | 
|                                                                                                               |  |              |            |  |         |   |       |            |  |   |              |   |  |             |   |  |             |   |   |        | 
|Net loss                                                                                                       |  |              | -          |  |         |   | -     |            |  |   | -            |   |  |             | - |  |             |   | - |        | 
|                                                                                                               |  |              |            |  |         |   |       |            |  |   |              |   |  |             |   |  |             |   |   |        | 
|Balance at December 31, 2011                                                                                   |  |              | 62,034,146 |  |         | $ | 6,203 |            |  | $ | 216,984,108  |   |  | $           | - |  |             | $ | - |        | 
|                                                                                                               |  |              |            |  |         |   |       |            |  |   |              |   |  |             |   |  |             |   |   |        | 
|Stock-based compensation                                                                                       |  |              | -          |  |         |   | -     |            |  |   | 1,828,204    |   |  |             | - |  |             |   | - |        | 
|                                                                                                               |  |              |            |  |         |   |       |            |  |   |              |   |  |             |   |  |             |   |   |        | 
|Sale and issuance of common stock in January 2012 at approximately $4.44 per share, net of issuance
    costs  |  |              | 4,989,275  |  |         |   | 499   |            |  |   | 22,151,352   |   |  |             | - |  |             |   | - |        | 
|                                                                                                               |  |              |            |  |         |   |       |            |  |   |              |   |  |             |   |  |             |   |   |        | 
|Common stock issued in 2012 at par, pursuant to net-share (cashless) exercises of common stock
    warrants    |  |              | 17,148     |  |         |   | 2     |            |  |   | (2           | ) |  |             | - |  |             |   | - |        | 
|                                                                                                               |  |              |            |  |         |   |       |            |  |   |              |   |  |             |   |  |             |   |   |        | 
|Stock options exercised                                                                                        |  |              | 35,210     |  |         |   | 4     |            |  |   | 7,190        |   |  |             | - |  |             |   | - |        | 
|                                                                                                               |  |              |            |  |         |   |       |            |  |   |              |   |  |             |   |  |             |   |   |        | 
|Net loss                                                                                                       |  |              | -          |  |         |   | -     |            |  |   | -            |   |  |             | - |  |             |   | - |        | 
|                                                                                                               |  |              |            |  |         |   |       |            |  |   |              |   |  |             |   |  |             |   |   |        | 
|Balance at December 31, 2012                                                                                   |  |              | 67,075,779 |  |         | $ | 6,708 |            |  | $ | 240,970,852  |   |  | $           | - |  |             | $ | - |        | 



See accompanying notes to consolidated
financial statements.



F-9







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



CONSOLIDATED STATEMENTS OF CASH FLOWS



|                                                                                                      |  |                                      |             |   |         |   |             |      |  |   | Period from       |  
|----------------------------------------------------------------------------------------------------- |  | ------------------------------------ | ----------- | - | ------- | - | ----------- | ---- |  | - | ----------------- | -
|                                                                                                      |  |                                      |             |   |         |   |             |      |  |   | April 3, 2002     |  
|                                                                                                      |  |                                      |             |   |         |   |             |      |  |   | (inception)       |  
|                                                                                                      |  | For the years ended
    December 31, |             |   | through |  
|                                                                                                      |  | 2012                                 |             |   | 2011    |   |             | 2010 |  |   | December 31, 2012 |  
|Operating activities:                                                                                 |  |                                      |             |   |         |   |             |      |  |   |                   |  
|Net loss                                                                                              |  | $                                    | (31,735,909 | ) |         | $ | (50,452,165 | )    |  | $ | (37,330,069       | )
|Adjustments to reconcile net loss to net cash used
    in operating activities:                       |  |                                      |             |   |         |   |             |      |  |   |                   |  
|Non-cash stock-based compensation                                                                     |  |                                      | 1,828,204   |   |         |   | 2,648,741   |      |  |   | 1,986,755         |  
|Depreciation and amortization                                                                         |  |                                      | 127,350     |   |         |   | 116,465     |      |  |   | 75,610            |  
|Stock issued for license fee                                                                          |  |                                      | -           |   |         |   | -           |      |  |   | -                 |  
|Non-cash interest expense                                                                             |  |                                      | -           |   |         |   | -           |      |  |   | -                 |  
|Loss (gain) on disposition of fixed assets                                                            |  |                                      | 25,158      |   |         |   | -           |      |  |   | -                 |  
|Fair value of warrants for finder's fee                                                               |  |                                      | -           |   |         |   | -           |      |  |   | -                 |  
|Changes in operating assets and liabilities:                                                          |  |                                      |             |   |         |   |             |      |  |   |                   |  
|Prepaid contract research and manufacturing expenses,
    other prepaid expenses and other assets     |  |                                      | 615,740     |   |         |   | (404,377    | )    |  |   | (139,164          | )
|Accounts payable, accrued contract research and manufacturing
    expenses and other accrued expenses |  |                                      | (9,848,177  | ) |         |   | (200,603    | )    |  |   | 2,882,709         |  
|Accrued restructuring                                                                                 |  |                                      | 841,184     |   |         |   | -           |      |  |   | -                 |  
|Accrued compensation and related expenses                                                             |  |                                      | (1,219,502  | ) |         |   | 252,355     |      |  |   | 272,386           |  
|Net cash used in operating activities                                                                 |  |                                      | (39,365,952 | ) |         |   | (48,039,584 | )    |  |   | (32,251,773       | )
|                                                                                                      |  |                                      |             |   |         |   |             |      |  |   |                   |  
|Investing activities:                                                                                 |  |                                      |             |   |         |   |             |      |  |   |                   |  
|Acquisitions of property and equipment                                                                |  |                                      | (25,260     | ) |         |   | (227,468    | )    |  |   | (151,836          | )
|Proceeds from sale of assets                                                                          |  |                                      | 12,230      |   |         |   | -           |      |  |   | -                 |  
|Purchases of short-term investments                                                                   |  |                                      | -           |   |         |   | (65,605,570 | )    |  |   | -                 |  
|Redemptions of short-term investments                                                                 |  |                                      | 4,500,000   |   |         |   | 61,105,570  |      |  |   | 11,450,000        |  
|Security deposits                                                                                     |  |                                      | 38,267      |   |         |   | (172        | )    |  |   | 38,855            |  
|Net cash (used in) provided by investing activities                                                   |  |                                      | 4,525,237   |   |         |   | (4,727,640  | )    |  |   | 11,337,019        |  
|                                                                                                      |  |                                      |             |   |         |   |             |      |  |   |                   |  
|Financing activities:                                                                                 |  |                                      |             |   |         |   |             |      |  |   |                   |  
|Proceeds from borrowings from affiliate                                                               |  |                                      | -           |   |         |   | -           |      |  |   | -                 |  
|(Repayment of) borrowings from line of credit                                                         |  |                                      | -           |   |         |   | -           |      |  |   | (11,466,012       | )
|Proceeds from exercise of stock options                                                               |  |                                      | 7,194       |   |         |   | -           |      |  |   | -                 |  
|Proceeds from exercise of common stock warrants                                                       |  |                                      | -           |   |         |   | 8,480,135   |      |  |   | 275,331           |  
|Proceeds from sales of equity securities, net of issuance
    costs                                   |  |                                      | 22,151,851  |   |         |   | 37,726,538  |      |  |   | 57,403,841        |  
|Receipt of recovery of short-swing profits                                                            |  |                                      | -           |   |         |   | 73,797      |      |  |   | -                 |  
|Recapitalization of the Company                                                                       |  |                                      | -           |   |         |   | -           |      |  |   | -                 |  
|Receipt of cash for stock subscription receivable                                                     |  |                                      | -           |   |         |   | -           |      |  |   | -                 |  
|Net cash provided by financing activities                                                             |  |                                      | 22,159,045  |   |         |   | 46,280,470  |      |  |   | 46,213,160        |  
|                                                                                                      |  |                                      |             |   |         |   |             |      |  |   |                   |  
|Net (decrease) increase in cash and cash equivalents                                                  |  |                                      | (12,681,670 | ) |         |   | (6,486,754  | )    |  |   | 25,298,406        |  
|Cash and cash equivalents, beginning of period                                                        |  |                                      | 41,106,301  |   |         |   | 47,593,055  |      |  |   | 22,294,649        |  
|Cash and cash equivalents, end of period                                                              |  | $                                    | 28,424,631  |   |         | $ | 41,106,301  |      |  | $ | 47,593,055        |  
|                                                                                                      |  |                                      |             |   |         |   |             |      |  |   |                   |  
|Supplemental disclosure of cash flow information:                                                     |  |                                      |             |   |         |   |             |      |  |   |                   |  
|                                                                                                      |  |                                      |             |   |         |   |             |      |  |   |                   |  
|Cash paid for interest                                                                                |  | $                                    | -           |   |         | $ | -           |      |  | $ | 70,389            |  



See accompanying notes to consolidated
financial statements.



F-10







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



CONSOLIDATED STATEMENTS OF CASH FLOWS



Supplemental disclosure of non-cash investing and financing
activities:



During 2002, the Company issued 5,428,217
shares of its common stock for a subscription receivable of $4,625.



During 2004, the Company converted a loan
with an affiliate for aggregate principal of $1,745,000 and accrued interest of $34,020 into shares of its common stock, issuing
677,919 shares, at approximately $2.62 per share in lieu of repayment of this obligation.



In December 2004, in conjunction with
and as compensation for activities related to the December 2004 sale of equity securities, the Company issued warrants to purchase
483,701 shares of its common stock, with a purchase price of approximately $2.88 per share and an aggregate fair value of $14,400.
All of these warrants were exercised by the holders prior to their expiration in December 2011.



In conjunction with the merger and recapitalization
of the Company effective February 11, 2005, the Company issued 11,911,357 shares of its common stock in exchange for all of the
issued and outstanding shares of Chelsea Therapeutics, Inc. In addition, in conjunction with and as compensation for facilitating
the merger, the Company issued warrants for the purchase of 105,516 shares of its common stock at an exercise price of $2.62 per
share and an aggregate fair value of $26,700. As of December 31, 2012, all of these warrants had been exercised.



In February 2006, in conjunction with
and as compensation for activities related to the February 2006 sale of equity securities, the Company issued warrants to purchase
716,666 shares of its common stock, with a purchase price of $3.30 per share and an aggregate fair value of approximately $705,000.
Of these, warrants for the purchase of 486,766 shares remained unexercised and outstanding as of December 31, 2012. However, they
remained unexercised and expired in February 2013.



In May 2006, in conjunction with and as
compensation for activities related to a licensing agreement and under a Finder’s Agreement, the Company issued warrants
to purchase 250,000 shares of its common stock, with an exercise price of $4.31 per share. The exercise of these warrants was
conditioned on an event that occurred in January 2007 and, accordingly, the Company recorded a charge based on the warrants’
fair value determined at January 2007 of $433,750. As of December 31, 2012, all of these warrants remain unexercised and outstanding
and are scheduled to expire in May 2013.



See accompanying
notes to consolidated financial statements.



F-11







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



NOTES TO CONSOLIDATED FINANCIAL STATEMENTS



1. The Company, Basis of Presentation and Summary of Significant
Accounting Policies



The Company



Chelsea Therapeutics International, Ltd.
(“Chelsea Ltd.” or the “Company”) is a development stage pharmaceutical company focused on the acquisition,
development and commercialization of innovative pharmaceutical products. Specifically, the Company is developing NortheraTM
(droxidopa), a novel therapeutic agent for the treatment of symptomatic neurogenic orthostatic hypotension, or Neurogenic OH,
in patients with primary autonomic failure, dopamine β-hydroxylase, or DBH, deficiency and non-diabetic autonomic neuropathy.
The Company also has an interest in evaluating other potentially norepinephrine related conditions and diseases including intradialytic
hypotension, fibromyalgia and adult attention deficit hyperactivity disorder. The Company has also devoted resources to the development
of pharmaceuticals for multiple autoimmune disorders, including rheumatoid arthritis, psoriasis, inflammatory bowel disease and
cancer. The Company’s operating subsidiary, Chelsea Therapeutics, Inc. (“Chelsea Inc.”), was incorporated in
the State of Delaware on April 3, 2002 as Aspen Therapeutics, Inc., with the name changed in July 2004. In February 2005, Chelsea
Inc. merged with a wholly-owned subsidiary of Chelsea Ltd.’s predecessor company, Ivory Capital Corporation (“Ivory”),
a Colorado public company with no operations (the “Merger”). The Company reincorporated into the State of Delaware
in July 2005, changing its name to Chelsea Therapeutics International, Ltd.



As a result of the Merger of Ivory and
Chelsea Inc. in February 2005, and the reincorporation in Delaware in July 2005, Chelsea Ltd. is the reporting company and is
the 100% owner of Chelsea Inc. The separate existence of Ivory ceased in connection with the Delaware reincorporation in July
2005. Except where the context provides otherwise, references to the “Company” and similar terms mean Ivory, Chelsea
Ltd. and Chelsea Inc.



Basis of Presentation



Since inception, the Company has focused
primarily on organizing and staffing, negotiating in-licensing agreements with partners, acquiring, developing and securing its
proprietary technology, participating in regulatory discussions with the United States Food and Drug Administration, or FDA, the
European Medicines Agency, or EMA and other regulatory agencies, undertaking preclinical trials and clinical trials of product
candidates and raising capital. In addition, during late 2011 and early 2012, the Company conducted activities in preparation
for the planned commercial launch of Northera but, upon receipt of the complete response letter, or CRL, from the FDA in March
2012, brought such activities to a close. The Company is a development stage company and has generated no revenue since inception.



The Company has sustained operating losses
since its inception and expects that such losses could continue for the foreseeable future. Management plans to continue financing
the Company’s operations, as necessary, with equity issuances, debt arrangements, strategic alliances or other arrangements
of a collaborative nature. If adequate funds are not available, the Company may be required to delay, reduce the scope of, or
eliminate one or more of its research or development programs, delay or scale back certain activities including its commercialization
program, or limit or cease operations in which event its business, financial condition and results of operations would be materially
harmed.



The Company believes that capital resources
available at December 31, 2012 will be sufficient to meet its operating needs into the third quarter of 2014. This estimate assumes
the planned costs of currently ongoing clinical activity and a planned new trial of Northera that could begin patient dosing as
early as the fourth quarter of 2013 with a significant ramp in spending in the third quarter of 2013. In addition to the initial
costs of a new clinical trial, this estimate also assumes various costs related to the planned 2013 resubmission of the Northera
New Drug Application, or NDA, with the FDA.



For presentation purposes, the Company
has restated all information, where applicable, contained in this report related to shares authorized, issued and outstanding
and related disclosures of weighted average shares and loss per share to reflect the results of the Delaware reincorporation in
July 2005 as if the Delaware reincorporation had occurred at the beginning of each of the periods presented.



Basis of Consolidation



The accompanying financial statements present,
on a consolidated basis, the financial position and results of operations of Chelsea Ltd. and its subsidiary. All significant
intercompany transactions and balances have been eliminated in consolidation.



F-12







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



NOTES TO CONSOLIDATED FINANCIAL STATEMENTS



Use of Estimates



The preparation
of financial statements in conformity with accounting principles generally accepted in the United States of America requires management
to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent
liabilities at the date of the financial statements as well as the reported expenses during the reporting periods. On an ongoing
basis, management evaluates its estimates and judgments. Management bases estimates on its historical experience and on various
other factors that it believes are reasonable under the circumstances, the results of which form the basis for making judgments
about the carrying value of assets and liabilities that are not readily apparent from other sources. Actual results might differ
from these estimates under different assumptions or conditions. The Companyconsiders an accounting
estimate to be critical if the accounting estimate requires management to make assumptions about matters that were uncertain at
the time the accounting estimate was made and where changes in the estimate that could occur from period to period, or use of
different reasonable estimates in the current period, would have a material impact on our financial condition or results of operations.



Significant
estimates and assumptions are required related to the estimated costs and estimated percentages of completion of research and
development activities that are outsourced to third-party contractors, the valuation of assets and stock-based compensation. Some
of these judgments can be subjective and complex, and, consequently, actual results may differ from these estimates. For any given
individual estimate or assumption made by the Company, there may also be other estimates or assumptions that are reasonable. Although
the Company believes that its estimates and assumptions are reasonable, they are based upon information available at the time
the estimates and assumptions were made. Actual results may differ significantly from such estimates.



Cash and Cash Equivalents



Cash and cash equivalents consist of cash
and other highly-liquid investments with maturities of three months or less at the date of purchase.



Short-Term Investments



During 2011 and early 2012, the Company
held short-term investments consisting of investments in certificates of deposit, or CD’s, with maturities of 26-weeks as
of the dates of purchase, that were purchased through the Certificate of Deposit Account Registry Service, or CDARS®. Investments
were made through a single CDARS Network member and when a large deposit was made, that institution used the CDARS service to
place funds into CDs issued by other members of the CDARS Network. Investments occur in increments below the standard Federal
Deposit Insurance Corporation, or FDIC, insurance maximum ($250,000) so that both principal and interest were eligible for FDIC
insurance. The Company also held, at various points during 2011, short-term investments in commercial paper and corporate bonds,
all of which had been redeemed as of December 31, 2011. In addition, the Company held additional CDARS investments during 2011
that were classified as cash equivalents based on their 13-week maturities at the dates of purchase.



Concentration of Credit Risk



Financial instruments that potentially
subject the Company to a significant concentration of credit risk consist primarily of cash and cash equivalents. A portion of
the Company’s cash has been maintained in non-interest bearing accounts at federally insured financial institutions that,
under the Transaction Account Guarantee Program, or TAGP, of the Federal Deposit Insurance Corporation, or FDIC. This program
expired on December 31, 2012. The Company continues to maintain deposits in commercial accounts in excess of federally insured
amounts ($250,000 for each account), primarily in fully liquid interest-bearing money market accounts, money market funds and
Treasury funds. However, while giving consideration to the expiration of the TAGP at December 31, 2012, management believes the
Company is not exposed to significant credit risk for its cash and cash equivalents due to the financial position of the depository
institutions in which those deposits are held and the nature of the investments.



Fair Value of Financial Instruments



The carrying value of the Company’s
financial instruments, including cash and cash equivalents and accounts payable approximates fair value given their highly-liquid
and short-term nature.



F-13







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



NOTES TO CONSOLIDATED FINANCIAL STATEMENTS



Property and Equipment



Property and equipment, which consists
of furniture and fixtures, software and equipment, is stated at cost and depreciated or amortized using the straight-line method
over the estimated useful lives of the related assets. The useful life for all classes of assets other than leasehold improvements
is three years. The useful life for leasehold improvements is the shorter of the expected life of the leasehold improvement or
the remaining term of the lease.



Impairment of Long-Lived Assets



The Company reviews long-lived assets,
including property and equipment, for impairment whenever events or changes in business circumstances indicate that the carrying
amount of the assets may not be fully recoverable. An impairment loss would be recognized when estimated undiscounted future cash
flows expected to result from the use of the asset and its eventual disposition are less than its carrying amount. The impairment
loss, if recognized, would be based on the excess of the carrying value of the impaired asset over its respective fair value.
Impairment, if any, is assessed using undiscounted cash flows. Through December 31, 2012, there has been no such impairment.



Research and Development



Research and development expenditures are
expensed based upon the most recent estimate of costs needed to complete such activities. The Company often contracts with third
parties contract research organizations, or CROs, to facilitate, coordinate and perform agreed upon research and development activities. 
Expense recognition is based upon estimated percentage of completion at the financial statement date applied against estimated
amounts to complete the project. Estimates are calculated, maintained and presented to the Company by CROs and are then subjected
to rigorous periodic internal review and analysis to ensure reasonableness of the estimates. Such review includes difficult, subjective
and complex judgments, particularly in instances of studying orphan drug candidates where prior clinical activity is limited,
providing little or no historical cost information. Given the highly variable nature of the costs involved in the completion of
a clinical or pre-clinical trial, fluctuations in costs estimates can occur at any time during the trial or at its conclusion
based on a number of factors including, but not limited to, the rate at which investigator sites are identified, site locations
(US versus International), the timing of site activations, the rate at which patients are enrolled into a trial, changes to the
number of sites and/or patients that are targeted for the trial, the timelines for trial completion and changes in scope of the
actions to be taken by the contractor.



Given that the recognition of expense related
to the Company’s contracted research and development activities comprise a significant component of reported expenses during
any given period, such fluctuations can be material to the results of operations and/or the carrying value of assets and liabilities.
The estimates to complete each contracted project are also used in the determination and disclosure of contractual obligations
of the Company providing a snapshot of estimated cash requirements arising from future contractual payment obligations based upon
the best information available at the time the financial statements are published.



To ensure that research and development
costs are expensed as incurred, the Company measures expense based on estimated work performed for the underlying contract, typically
utilizing a percentage-of-completion approach, and records prepaid assets or accrues expenses on a monthly basis for such activities
based on the measurement of liability from expense recognition and the receipt of invoices. Contracts for research and development
programs typically call for the payment of fees for services at the initiation of the contract and/or upon the achievement of
certain milestones.  In the event that the Company prepays fees for future milestones, the Company records the prepayment
as a prepaid asset and amortizes the asset into research and development expense over the period of time the contracted research
and development services are performed.  Most fees are incurred throughout the contract period and are expensed based on
their estimated percentage of completion at a particular date. Although such fees may fluctuate during the life of a research
and development program, such fluctuations are generally based on changes in or delays in the timelines for study completion



These contracts generally include pass
through fees.  Pass through fees include, but are not limited to, regulatory expenses, investigator fees, travel costs, and
other miscellaneous costs including shipping and printing fees.  Because these fees are incurred at various times during
the contract term and they are used throughout the contract term, the Company records a monthly expense allocation to recognize
the fees during the contract period.  Fees incurred to set up the clinical trial are expensed during the setup period. Estimating
the costs of pass-through expenses for a contracted research and development program can be difficult and complex. Judgments used
in the development of these estimates include the input of the CRO, the costs of previous clinical trials, estimates of patient
recruitment rates, estimates of drop-out rates and estimates of site identification and activation rates. Estimates of investigator
payments, lab costs, database development and management and adverse event reporting are based on parameters such as number of
office visits, laboratory requirements, screening failure rates, location of the investigator site and the patient related factors
discussed above. Historically, the Company has experienced fluctuations in the estimates of thee costs and has implemented rigorous
review processes to ensure reliability of estimates. Fluctuations that have occurred previously have been in the range of +/-
5% of total program costs and the Company would anticipate that similar fluctuations could occur in the future. Depending on the
size of the trial, the estimated costs to complete and the volume of overall research and development activities during any given
period, such fluctuations could be material to the results of operations and financial position (see Note 6).



F-14







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



NOTES TO CONSOLIDATED FINANCIAL STATEMENTS



Costs related to the acquisition of technology
rights and patents for which development work is still in process are expensed as incurred and considered a component of research
and development costs.



Loss per Share



Basic net loss per common share is calculated
by dividing net loss by the weighted-average number of common shares outstanding for the period, without consideration for potentially
dilutive securities. For the periods presented, basic and diluted net loss per common share are identical as potentially dilutive
securities from stock options and stock warrants would have an antidilutive effect since the Company incurred a net loss. The
number of shares of common stock potentially issuable at December 31, 2012, 2011 and 2010 upon exercise or conversion that were
not included in the computations of net loss per share were 9,099,600, 8,687,452 and 9,917,518, respectively.



Income Taxes



The Company determines deferred tax assets
or liabilities based on the difference between the financial statement and the tax bases of assets and liabilities as measured
by the enacted tax rates, which will be in effect when these differences reverse. The Company provides a valuation allowance against
net deferred tax assets unless, based upon the available evidence, it is more likely than not that the deferred tax assets will
be realized.



The Company also recognizes, in its consolidated
financial statements, the impact of a tax position if that position is more likely than not to be sustained upon examination,
based on the technical merits of the position and provides explicit disclosure about the Company’s uncertainties related
to the income tax position, including a detailed roll-forward of tax benefits taken that do qualify for financial statement recognition.



Stock-Based Compensation



The Company accounts for its stock
options using a fair value based method of accounting for stock options or similar equity instruments and requires the
measurement and recognition of compensation expense for all share-based payment awards made to employees and non-employee
directors based on estimated fair values determined using an option-pricing model. The value of the portion of the award that
is ultimately expected to vest is recognized as expense on a straight-line basis over the requisite service periods in the
Company’s statements of operations.



The fair value of each option award made
to employees and directors during the years ended December 31, 2012, 2011 and 2010 was estimated on the date of grant using the
Black-Scholes closed-form option valuation model utilizing the assumptions noted in the following table. To determine the risk-free
interest rate, the Company utilized the U.S. Treasury yield curve in effect at the time of grant with a term consistent with the
expected term of the Company’s awards. The Company estimated the expected life of the options granted based on anticipated
exercises in future periods. The expected dividends reflect the Company’s current and expected future policy for dividends
on its common stock. Effective January 1, 2011, the Company began relying exclusively on the trading and price history of the
Company’s stock in order to determine the expected volatility given that, as of that date, there existed sufficient trading
history to be able to determine historical volatility. Prior to that, the Company examined historical volatilities for industry
peers closely related to the current status of its business, but with sufficient trading history to be able to determine volatility.
The Company plans to continue to analyze the expected stock price volatility and expected term assumption at each grant date as
more historical data for its common stock becomes available. As of January 1, 2011, taking into consideration hiring completed
and planned by the Company and the potential impact of forfeitures given the roles of these newly filled positions, the Company
estimated a forfeiture rate of 3%. Given the events of 2012 and the corporate restructuring announced in July 2012 that have negatively
impacted the Company’s staffing levels, the estimated forfeiture rate was changed to 24% for the first six months of 2012
and the impact of this change in estimate was recognized as a cumulative catch-up and serves to reduce the stock-based compensation
costs for the quarter ended June 30, 2012. In July 2012, the Company again reviewed its estimated forfeiture rate, based upon
the adjusted staffing levels resulting from the corporate restructuring and, effective at that date, modified its estimated forfeiture
rate to 11.5%. Prior to 2011, given the Company’s low historical rate of attrition and the senior nature of the roles for
a significant portion of the Company’s employees, the Company estimated that it would experience no forfeitures or that
the rate of forfeiture would be immaterial to the recognition of compensation expense for those options outstanding. Due to the
limited amount of historical data available to the Company, particularly with respect to stock-price volatility, employee exercise
patterns and forfeitures, actual results could differ from the Company’s assumptions. The table below summarizes the assumptions
utilized in estimating the fair value of the stock options granted during the years ended December 31, 2012, 2011 and 2010:



F-15







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



NOTES TO CONSOLIDATED FINANCIAL STATEMENTS



|                                          |  | For the years ended December 31, |        
|----------------------------------------- |  | -------------------------------- | -------
|                                          |  | 2012                             |        
|Weighted-average risk-free interest rate  |  |                                  | 0.74   
|Weighted-average expected life of options |  |                                  | 5 years
|Expected dividend yield                   |  |                                  | 0      
|Weighted-average expected volatility      |  |                                  | 89.73  
|Anticipated forfeiture rate               |  |                                  | 12     



The table below summarizes the
compensation expense recorded by the Company for the years ended December 31, 2012, 2011 and 2010 in conjunction with option
grants made to employees and non-employee directors:



|                                                        |  | For the year ended December 31, |          
|------------------------------------------------------- |  | ------------------------------- | ---------
|                                                        |  | 2012                            |          
|Stock-based compensation expense recorded during period |  | $                               | 1,828,203
|Total unrecognized compensation expense remaining       |  | $                               | 4,173,830
|Remaining average recognition period (in years)         |  |                                 | 2.81     



As a result of the Company’s restructuring activities,
stock-based compensation recorded for the year ended December 31, 2012 reflects the reversal of stock compensation expense for
unvested options that were forfeited during the period and the impact of option modifications made for former executives and former
Board members as a component of their resignations. The expected future amortization expense for unrecognized compensation expense
for stock option grants to employees and non-employee directors at December 31, 2012 is as follows:



|Year ending December 31, 2013 |  | $ | 1,550,467 | 
|----------------------------- |  | - | --------- | 
|Year ending December 31, 2014 |  |   | 1,316,481 | 
|Year ending December 31, 2015 |  |   | 907,591   | 
|Year ending December 31, 2016 |  |   | 399,291   | 
|                              |  | $ | 4,173,830 | 



Although no such grants have been made
by the Company since 2005 (none of which remain outstanding as of December 31, 2012), option awards to consultants, advisors or
other independent contractors are granted with an exercise price equal to the market price of the Company’s stock at the
date of the grant, have 10-year contractual terms and vest dependent upon the completion of performance commitments. As such,
the value of stock options is measured at the then-current market value as of financial reporting dates and compensation cost
is recognized for the net change in the fair value of the options for the reporting period, until such performance commitments
are met. Once each commitment is met, the options that vest in association with that commitment are adjusted, for the last time,
to the then-current fair value and compensation cost is recognized accordingly. No expense related to third-party grants were
recognized during 2012, 2011 or 2010.



In determining the fair value of options
granted to consultants, advisors and other independent contractors, the Company uses the Black-Scholes closed-form option valuation
model in a manner consistent with its use in determining the fair value of options granted to employees and directors. However,
the expected life of the options is based on the contractual lives as defined in agreements with the third parties.



F-16







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



NOTES TO CONSOLIDATED FINANCIAL STATEMENTS



2. Short-term Investments



As of December 31, 2011, the Company held
short-term investments of $4.5 million consisting of investments in CD’s with maturities of 26-weeks as of the dates of
purchase. Such investments, made at various times during 2011, were purchased through CDARS. During 2011, the Company also held
short-term investments in commercial paper and corporate bonds that, at maturity, were fully redeemed.



During 2010, the Company liquidated its
remaining investments in auction rate securities, or ARS, by exercising the ARS Rights received under a settlement agreement,
finalized in the fourth quarter of 2008, with UBS Financial Services, Inc., or UBS. At January 1, 2010, the Company held total
investments in ARS with a par value of approximately $11.45 million that were classified as trading securities and held at UBS.
These ARS investments represented interests in collateralized debt obligations supported by pools of student loans and none were
collateralized by mortgage, credit card or insurance securitizations. The ARS Rights provided the Company with the ability to
sell the ARS, along with the ARS Rights, to UBS at the par value of the ARS no earlier than June 30, 2010 and were to expire on
July 2, 2012. The ARS Rights were not transferable, not tradable, were not quoted or listed on any securities exchange or any
other trading network, were recorded at fair value and were classified as short-term investments. Additionally, UBS also agreed
that an affiliate would provide the Company with a no net-cost line of credit. Under the terms of the line of credit agreements,
the Company received funds in December 2008 and March 2009 equivalent to 100% of the par value of the Company’s ARS investments,
providing the Company with full liquidity for all its investments in ARS held with UBS. Upon exercise of the ARS Rights on June
30, 2010 and, after applying the proceeds of the redemptions of those ARS Rights, the Company had no remaining liability under
the line of credit. During 2010, based upon analysis of fair value, the Company recorded no additional trading loss related to
its trading securities or any corresponding adjustment to the fair value of its ARS or ARS Rights, prior to redemption on June
30, 2010.



3. Fair Value Measurements



In determining fair value, the Company
utilizes techniques that optimize the use of observable inputs, when available, and minimize the use of unobservable inputs to
the extent possible. At December 31, 2012, assets measured at fair value on a recurring basis consisted of cash and cash equivalents
of approximately $28.4 million. Based on the short-term liquid nature of these assets, the fair value, determined using level
1 inputs, is equivalent to the recorded book value.



At December 31, 2011, assets measured at
fair value on a recurring basis consisted of cash and cash equivalents of approximately $41.1 million and short-term investments
of $4.5 million. Based on the short-term liquid nature of these assets, the fair value, determined using level 1 inputs, was equivalent
to the recorded book value.



4. Property and equipment:



Property and equipment consist of the following:

|                                                 |  | December 31, |         
|------------------------------------------------ |  | ------------ | --------
|                                                 |  | 2012         |         
|Furniture and fixtures                           |  | $            | 285,987 
|Software                                         |  |              | 57,563  
|Leasehold improvements                           |  |              | 39,909  
|Computer and office equipment                    |  |              | 245,578 
|                                                 |  |              | 629,037 
|Less - accumulated depreciation and amortization |  |              | (477,493
|                                                 |  | $            | 151,544 



Depreciation and amortization expense was
$127,350, $116,465 and $75,610 for the years ended December 31, 2012, 2011 and 2010, respectively.



5. Common Stock Offerings



In November 2012, the Company filed the
required documents and became eligible to use an at-the-market common equity sales program for the sale of shares of common stock
up to an aggregate offering price of $20,000,000. These shares were offered pursuant to the Company’s 2012 shelf registration
statement. No equity sales have been made under this program at December 31, 2012.



F-17







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



NOTES TO CONSOLIDATED FINANCIAL STATEMENTS



On February 8, 2012, the Company amended
its shelf registration statement, originally filed on January 26, 2012, with the SEC, under which the Company may offer shares
of its common stock and preferred stock, various series of debt securities and/or warrants to purchase any of such securities,
either individually or in units, in one or more offerings, up to a total dollar amount of $100,000,000. Such registration statement,
as amended, became effective as of February 9, 2012.



On January 11, 2012, the Company raised
gross proceeds of approximately $23.7 million through the sale of 4,989,275 shares of its common stock in a publicly-marketed
offering. These shares were offered pursuant to the Company’s 2011 shelf registration statement, as amended effective January
5, 2012 pursuant to Rule 462(b) to increase the dollar amount of securities available for sale, filed with the SEC under which
the Company could offer shares of its common stock and preferred stock, various series of debt securities and/or warrants to purchase
any of such securities, either individually or in units, in one or more offerings, up to a total dollar amount of $63,950,000.
Such registration statement became effective as of January 19, 2011. In connection with this offering, the Company paid commissions
and other offering-related costs of approximately $1.6 million.



There are no more securities available
under the Company’s 2011 shelf registration.



On February 24, 2011, the Company raised
gross proceeds of approximately $40.3 million through the sale of 10,062,500 shares of its common stock in a publicly-marketed
offering. These shares were offered pursuant to the Company’s 2011 shelf registration statement, amended pursuant to Rule
462(b), filed with the SEC under which the Company could offer shares of its common stock and preferred stock, various series
of debt securities and/or warrants to purchase any of such securities, either individually or in units, in one or more offerings,
up to a total dollar amount of $63,950,000. Such registration statement became effective as of January 19, 2011. In connection
with this offering, the Company paid commissions and other offering-related costs of approximately $2.5 million.



On October 6, 2010, the Company raised
gross proceeds of approximately $40.3 million through the sale of 8,214,286 shares of its common stock in a publicly-marketed
offering. These shares were offered pursuant to the Company’s shelf registration statement, as amended effective October
1, 2010 pursuant to Rule 462(b) to increase the dollar amount of securities available for sale, as filed with the SEC under which
it may offer shares of its common stock and preferred stock, various series of debt securities and/or warrants to purchase any
of such securities, either individually or in units, in one or more offerings, up to a total dollar amount of $61,566,686. Such
registration statement became effective as of August 20, 2009.



In July 2010, the Company filed the required
documents and became eligible to use an at-the-market common equity sales program for the sale of up to 3,000,000 shares of common
stock. In September 2010, the Company sold 634,500 shares of common stock under this program resulting in net proceeds, after
expenses, of approximately $2.9 million, or $4.49 per share. These shares were offered pursuant to the Company’s 2009 shelf
registration statement.



On March 5, 2010, the Company raised gross
proceeds of approximately $18.2 million through the sale of 6,700,000 shares of its common stock plus warrants for the purchase
of 2,345,000 shares of its common stock (the “2010 Offering”). These warrants had an aggregate fair value of approximately
$3.9 million, permit the holders to purchase the underlying common shares at $2.79 each or elect a net share settlement and are
exercisable in whole at any time, or in part from time to time, during the period commencing six months after the date of issuance
and ending three years from the date of issuance. These shares were offered pursuant to the Company’s 2009 shelf registration
statement. In connection with this offering, the Company paid commissions and other offering-related costs of approximately $1.5
million.



There are no more securities available
under the Company’s 2009 shelf registration.



On July 28, 2009, the Company raised gross
proceeds of approximately $13.3 million through the sale of 3,325,000 shares of its common stock. These shares were offered pursuant
to the Company’s prior shelf registration statement, as amended effective July 22, 2009 pursuant to Rule 462(b) to increase
the dollar amount of securities available for sale, as filed with the SEC under which the Company could offer shares of its common
stock and preferred stock, various series of debt securities and/or warrants to purchase any of such securities, either individually
or in units, in one or more offerings, up to a total dollar amount of $62,218,060. Such registration statement became effective
as of October 11, 2007. In connection with this offering, the Company paid commissions and other offering-related costs of approximately
$0.9 million.



F-18







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



NOTES TO CONSOLIDATED FINANCIAL STATEMENTS



On November 8, 2007, the Company raised
gross proceeds of approximately $48.9 million through the sale of 7,388,172 shares of its common stock in a registered direct
offering. These shares were offered pursuant to the Company’s 2007 shelf registration statement. In connection with this
offering, the Company paid commissions and recorded or accrued other offering-related costs of approximately $3.2 million.



There are no more securities available
under the Company’s 2007 shelf registration.



On March 22, 2007, the Company raised gross
proceeds of approximately $12.5 million through the sale of 2,648,306 shares of its common stock plus warrants for the purchase
of 794,492 shares of its common stock (the “2007 Placement”). The aggregate fair value of these warrants was approximately
$1.3 million. The warrants permit the holders to purchase the underlying common shares at $5.66 each and are exercisable in whole
at any time, or in part from time to time, for cash, for five years from the date of issuance. The warrants are redeemable at
par value at the Company’s option in the event that the volume weighted-average closing price of the Company’s common
stock is greater than $12.00 per share for any 20 consecutive trading days provided the Company gives 60
business days’ written notice to the holders and simultaneously call all warrants on the same terms. Under the terms
of the 2007 Placement, the Company agreed to and filed a registration statement with the SEC within 30 days of the closing for
the shares of common stock sold and the shares of common stock underlying the warrants and such registration became effective
on August 7, 2007. In connection with this offering, the Company paid commissions and other offering-related costs of approximately
$1.0 million in cash.



On February 13, 2006, the Company raised
gross proceeds of approximately $21.5 million through the sale of 7,166,666 shares of its common stock plus warrants for the purchase
of 2,149,999 shares of its common stock (the “2006 Placement”). The allocated aggregate fair value of these warrants
was approximately $1.1 million. The warrants permitted the holders to purchase the underlying common shares, for cash only, at
$4.20 each and were exercisable in whole at any time, or in part from time to time, for five years from the date of issuance.
(See Note 10) The warrants were redeemable at par value at the Company’s option in the event that the Company’s volume
weighted-average closing bid price of its common stock was greater than $9.00 per share for any 20 consecutive trading days provided
that the Company gave 30 business days’ written notice to the holders and simultaneously called
all warrants on the same terms. In connection with the 2006 Placement, the Company paid commissions and other offering-related
costs of approximately $1.6 million in cash and issued warrants to the placement agent for the purchase of 716,666 shares of the
Company’s common stock with an exercise price of $3.30 per share, or 110% of the price of the shares sold in the offering
and an aggregate fair value of approximately $0.7 million. These warrants are exercisable in whole at any time, or in part from
time to time, for cash or in a net share settlement, for seven years from the date of issuance. Under the terms of the 2006 Placement,
the Company agreed to and filed a registration statement with the SEC within 30 days of the closing for the shares of common stock
sold and the shares of common stock underlying the warrants and such registration became effective on March 29, 2006.



In December 2004, Chelsea, Inc. raised
gross proceeds of approximately $14.5 million through the sale of 5,532,994 shares of its common stock (the “2004 Placement”).
The amount raised includes the conversion of a $1.7 million stockholder loan along with accrued interest, for which a total of
677,919 shares of common stock were issued. In connection with this offering, Chelsea, Inc. paid commissions and other offering-related
costs of approximately $1.0 million in cash and issued warrants to the placement agent for the purchase of 483,701 shares of its
common stock with an aggregate fair value of approximately $14,000. The warrants permit the holders to purchase the underlying
common shares at $2.88 per share, and are exercisable in whole at any time, or in part from time to time, for cash or in a net
share settlement, for seven years from the date of issuance.



6. Commitments



Facility Lease



On October 21, 2010, the Company entered
into an amendment to its lease agreement, dated March 7, 2008, to increase the office space in Charlotte, North Carolina that
serves as its corporate headquarters. Occupancy of the additional space occurred in March 2011. Occupancy for the originally leased
space occurred in May 2008. Upon taking delivery of the newly added space and upon expiration of a free rental period of six months
from the date of delivery, the monthly payments under the lease are approximately $30,000.  The lease, as amended, expires
on or about March 11, 2016 and calls for annual rent increases of 3%. A security deposit of approximately $38,000 was returned
to the Company in 2012 per the terms of the lease. The future aggregate minimum lease payments under non-cancellable operating
leases are approximately $1.2 million through the lease expiration date of March 2016.



Rent expense for the years ended December
31, 2012, 2011 and 2010 was $358,439, $339,963 and $202,267, respectively.



F-19







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



NOTES TO CONSOLIDATED FINANCIAL STATEMENTS



License Agreements



In March 2004, the Company entered into
a license agreement with Dr. M. Gopal Nair, Ph.D., of the University of South Alabama College of Medicine, for the rights to use,
produce, distribute and market products derived from an invention by Dr. Nair, claimed in US Patent # 5,912,251, entitled “metabolically
inert anti-inflammatory and antitumor antifolates”, designated by the Company as CH-1504 and related compounds. The license
provides the Company exclusive, worldwide (excluding India) rights for CH-1504 and related compounds. The Company made an upfront
payment in May 2004 of $150,000 and milestone payments as required by the agreement of $100,000 each in March 2006 and 2005. In
April 2007, the Company issued 26,643 shares of its common stock, subject to trading restrictions, at a value of approximately
$5.63 per share, in settlement of the $150,000 annual milestone payment liability. In March 2008, the Company made a milestone
payment of $100,000 related to patient dosing in a Phase II study as required by the agreement. In April 2008, the Company issued
30,612 shares of its common stock, subject to trading restrictions, at a value of approximately $4.90 per share, in settlement
of the 2008 anniversary milestone payment. In April 2009, the Company made the 2009 anniversary milestone payment of $150,000.
In September 2010, the Company made a milestone payment of $100,000 related to patient dosing in a Phase II study as required
by the agreement. The Company is obligated to pay royalties under the agreement until the later of the expiration of the applicable
patent or the applicable last date of market exclusivity after the first commercial sale, on a country-by-country basis. There
are no minimum royalties required under the agreement. The Company is also obligated to make future potential milestone payments
based on the achievement of specific development and regulatory approval milestones. Although the Company has no current development
activity ongoing for this portfolio of compounds, approximately $1.5 million of payments may become due if specific clinical or
regulatory milestones are achieved at a future date, subject to the Company’s right to terminate the license agreement.
In addition, should the Company enter into an out-licensing agreement, such payments could be offset by revenue received from
the sub-licensee.



In May 2006, the Company entered into an
agreement with Dainippon Sumitomo Pharma Co., Ltd. (“DSP”) for a worldwide, exclusive, sub-licensable license and
rights to certain intellectual property and proprietary information (the “DSP Agreement”) relating to L-threo-3,4-dihydroxyphenylserine
(“L-DOPS” or “droxidopa”) including, but not limited to all information, formulations, materials, data,
drawings, sketches, designs, testing and test results, records and regulatory documentation. As consideration for these rights,
the Company paid DSP $100,000 and issued 63,131 shares of its common stock, with a value of approximately $4.35 per share, or
$274,621. As additional consideration, the Company agreed to pay DSP and/or its designees (1) royalties on the sales should any
compound be approved for commercial sale, and (2) milestone payments, payable upon achievement of milestones as defined in the
DSP Agreement. In February 2008, the Company made a milestone payment under the DSP Agreement of $500,000 related to patient dosing
in a Phase III study. In December 2011, the Company made a milestone payment under the DSP Agreement of $750,000 related to submission
of an NDA to the FDA and has remaining potential future milestone payments, subject to the Company’s right to terminate
the DSP Agreement, totaling $2.5 million, including a potential milestone payment of $1.5 million payable upon approval of an
NDA. The Company and DSP also initiated, and the Company agreed to fund, activities focused on modifying the manufacturing capabilities
of DSP in order to expand capacity and comply with regulations and requirements of the FDA. Such work has been completed and,
based on work performed by DSP as of December 31, 2012, the Company had recorded cumulative expense of approximately $3.1 million.



In conjunction with and as consideration
for activities related to the execution of the DSP Agreement, the Company entered into a Finder’s Agreement with Paramount
BioCapital, Inc. (“Paramount”). In May 2006, pursuant to the Finder’s Agreement, the Company issued warrants
for the purchase of 250,000 shares of its common stock at an exercise price of $4.31 per share. The exercise of these warrants
was conditioned on an event that occurred in January 2007 and, accordingly, the Company recorded a charge for the fair value of
the warrants at January 2007 of $433,750. The Company utilized the Black-Scholes-Merton valuation model for estimating the fair
value of the warrants at the date the condition lapsed, based on a risk-free interest rate of 4.79%, an expected life of three
years, an expected dividend yield of 0%, an expected volatility of 66.01% and no estimated forfeitures. As additional consideration,
the Company agreed to (1) make future milestone payments to Paramount, upon achievement of milestones as defined in the Finder’s
Agreement, (2) pay royalties on sales should any licensed compound become available for commercial sale, and (3) compensate a
stated third-party consultant for services rendered in the evaluation of the transaction with DSP. The Company has remaining potential
future milestone payments under the Finder’s Agreement of $150,000.



The amount expended under these agreements
and charged to research and development expense was $750,000 during the year ended December 31, 2011 and $100,000 during the year
ended December 31, 2010.



F-20







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



NOTES TO CONSOLIDATED FINANCIAL STATEMENTS



Development and Commercialization Agreement



Effective May 2006, the Company entered
into a development and commercialization agreement (the “Development Agreement”) with Active Biotech AB (“AB”)
to co-develop and commercialize the I-3D portfolio of orally active, dihydroorotate dehydrogenase (“DHODH”) inhibiting
compounds for the treatment of autoimmune diseases and transplant rejection. Under the terms of the Development Agreement, an
initial payment of $1.0 million was made to AB at the time of the Development Agreement with such funds utilized to cover the
initial costs of research and development efforts jointly approved by both parties. At December 31, 2006, the Company had expensed
the entire $1.0 million payment and expensed additional costs of $0.3 million. During 2007, the Company expensed costs of $0.6
million under the program related to costs of research and development. During 2008, the Company and AB ceased joint discovery
efforts on this portfolio.



In April 2008, the Company and AB entered
into a termination and assignment agreement (the “Termination Agreement”), whereby AB discontinued its participation
in the I-3D co-development program and assigned its entire right, title and interest in the portfolio to the Company in exchange
for royalties on future sales. The Termination Agreement also eliminated the Company’s obligation related to payment of
potential future development milestones under the Development Agreement. The Company has recorded no costs related to this program
during 2012, 2011 or 2010.



Contract Research and Manufacturing Purchase Obligations



The Company often
contracts with third parties to facilitate, coordinate and perform agreed upon research and development and manufacturing activities.
These contracts typically call for the payment of fees for services at the initiation of the contract and/or upon the achievement
of certain milestones. The Company currently intends to continue its research and manufacturing activities as contracted at December
31, 2012. However, should a need arise to cancel activities under these contracts, there might be cancellation fees that could
be punitive in nature.



In addition, the Company has contracted
with a third party for the manufacture of commercial quantities of Northera prior to the date of final marketing approval and
might perform similar activities for other of its product candidates in the future. The scale-up and commercial production of
pre-launch inventories involves the risk that such products may not be approved for marketing by the appropriate regulatory agencies
on a timely basis, or ever. This risk notwithstanding, the Company initiated such activities with its primary supplier of active
pharmaceutical ingredient of Northera in December 2010 and had incurred expenses of approximately $1.2 million, $3.8 million and
$1.9 million related to these activities during 2012, 2011 and 2010, respectively. Until final approval to market any of the Company’s
product candidates is received from the appropriate regulatory agencies, such costs are expensed to research and development.
In addition, in October 2011, the Company committed to the purchase of active pharmaceutical ingredient from DSP to be used in
the production of commercial inventory in preparation for the market launch of Northera in the United States with a value of approximately
$7.2 million, given exchange rates at that time. A small initial shipment of this material was delivered in the first quarter
of 2012. In October 2012, the Company obtained a written waiver from the third-party manufacturer wherein the Company was released
from its obligation to purchase the remaining material under this agreement.



As more fully described in Significant
Accounting Policies (see Note 1), material fluctuations in the estimated costs to complete contracted research and development
activities of a material nature could occur during the normal course of business. Although the Company has a rigorous process
in place for the periodic review of the costs estimates utilized in accounting for expenses of contracted third-party research
activities, during the fourth quarter of 2012 the Company’s analysis resulted in changes in the estimates to complete its
Phase III clinical trial, Study 306B, and its estimate of final costs for its nearly completed Phase II clinical trial of CH-4051,
Study 202. At September 30, 2012, the Company had estimated the costs to complete Study 306B and its Northera extension studies
would be approximately $1.6 million from that date until the end of the first quarter of 2013. However, based upon updated information
obtained in the fourth quarter of 2012, the estimated costs to complete these programs were changed. Expenses had been recorded
in prior periods based upon previous estimates of these program costs and, as such, based on the changes in the estimates to complete,
the Company recorded, in the fourth quarter of 2012, a reversal of $0.9 million related to costs previously recorded. In addition,
the Company modified the estimated costs needed to complete these programs in the first quarter of 2013 to $0.5 million. Similarly,
the Company recorded a $0.5 million reduction in research and development expenses during the fourth quarter of 2012 for its Phase
II trial of the Company’s antifolates in rheumatoid arthritis. Although all costs associated with this trial had been recognized
in prior periods, the Company recorded the impact of this change in estimate in the fourth quarter of 2012.



Commitments under research and development
programs represent contractual commitments entered into for materials and services in the normal course of business and totaled
approximately $1.5 million at December 31, 2012.



F-21







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



NOTES TO CONSOLIDATED FINANCIAL STATEMENTS



Other Contractual Obligations



During 2011 and early 2012, the Company
contracted with various third parties to facilitate, coordinate and perform agreed upon commercialization support activities in
anticipation of approval to launch of Northera in the United States in 2012. These contracts typically called for the payment
of fees for services at the initiation of the contract and/or upon the achievement of certain milestones. In the event that the
Company prepaid fees for future milestones, it would have recorded the prepayment as a prepaid asset and amortized the asset into
sales and marketing expense over the period of time the contracted services were performed. Most fees were incurred throughout
the contract period and were expensed based on the percentage of completion at a particular date. During the second quarter of
2012, the Company successfully curtailed these activities and cancelled the associated contracts given the receipt of the CRL
from the FDA on March 28, 2012. The Company did incur a cancellation penalty on one of these contracts and, during the second
quarter of 2012, recorded $100,000 of sales and marketing expense related to that penalty.



Business activities
performed under these contracts included, but were not limited to, market research, marketing and advertising planning and development,
contracted Medical Science Liaison professionals, sales territory mapping, publication planning, sales force recruiting, sales
operations support and planning, messaging and website development, public relations and information technology support and planning.



7. Stockholders’ Equity



Preferred Stock



The Company’s Certificate of Incorporation
provides that the Board of Directors of the Company has the authority to issue up to an aggregate of 5,000,000 shares of preferred
stock in one or more classes or series and to determine, with respect to any such class or series, the designations, powers, preferences
and rights of such class or series, and the qualifications, limitations and restrictions thereof, including dividend rights, dividend
rates, conversion rights, voting rights, terms of redemption (including sinking fund provisions), redemption prices, liquidation
preferences and the number of shares constituting any class or series or the designation of such class or series, without further
vote or action by the stockholders.



As of December 31, 2012, no shares of preferred
stock were issued and outstanding.



Common Stock



In April 2008, the Company issued 30,612
shares of its common stock, subject to trading restrictions, at a value of approximately $4.90 per share, as consideration for
the $150,000 anniversary milestone payment due under its product license agreement with Dr. M. Gopal Nair (see Note 6).



In April 2007, the Company issued 26,643
shares of its common stock, subject to trading restrictions, at a value of approximately $5.63 per share, as consideration for
the $150,000 anniversary milestone payment due under its product license agreement with Dr. M. Gopal Nair (see Note 6).



In May 2006, the Company issued 63,131
shares of its common stock as consideration for a product license agreement with DSP (see Note 6), with a value of approximately
$4.35 per share, or $274,621.



During April 2004, the Company issued 471,816
common shares as consideration in the product license agreement (see Note 6) and 478,330 shares were sold to Simon Pedder, the
Company’s President and Chief Executive Officer under the terms of his employment agreement. These shares were valued at
what was, at that time, Chelsea’s common stock’s estimated aggregate fair value of $402 and $408, respectively, with
such nominal values reflecting an asset-based valuation methodology.



During 2002, the Company issued 5,428,217
shares of its common stock for a subscription receivable of $4,625.



Warrants



At December 31, 2012 and 2011, the Company
had outstanding warrants to purchase 2,023,530 and 2,875,022 shares, respectively, of the Company's common stock. Warrants outstanding
as of December 31, 2012 were issued at prices ranging from $2.79 to $4.31 per share.



F-22







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



NOTES TO CONSOLIDATED FINANCIAL STATEMENTS





On March 5, 2010, in conjunction with the
2010 Offering, the Company issued warrants for the purchase of 2,345,000 shares of its common stock. These warrants had an aggregate
fair value of approximately $3.9 million, permit the holders to purchase the underlying common shares at $2.79 each or elect a
net share settlement and are exercisable in whole at any time, or in part from time to time, during the period commencing six
months after the date of issuance and ending three years from the date of issuance. At December 31, 2012, warrants for the purchase
of 1,286,764 shares of the Company’s stock remained outstanding. However, these remaining unexercised warrants expired
on March 5, 2013.



In March 2007, in conjunction with the
2007 Placement (see Note 5), the Company issued warrants for the purchase of 794,492 shares of its common stock. The aggregate
fair value of these warrants was approximately $1.3 million. The warrants permitted the holders to purchase the underlying common
shares at $5.66 each and are exercisable in whole at any time, or in part from time to time, for cash, for five years from the
date of issuance. The warrants were redeemable at par value at the Company’s option in the event that the volume weighted-average
closing price of the Company’s common stock is greater than $12.00 per share for any 20 consecutive trading days provided
the Company gives 60 business days’ written notice to the holders and simultaneously call all
warrants on the same terms. Any remaining unexercised warrants expired in February 2012.



In May 2006, in conjunction with and as
compensation for activities related to the product license agreement with DSP (see Note 6) and under a finder’s agreement,
the Company issued warrants to purchase 250,000 shares of its common stock, with an exercise price of $4.31 per share. The exercise
of these warrants was conditioned on an event that did not occur until January 2007. As such, in January 2007, the Company recorded
a charge based on the warrants’ aggregate fair value at that date of $433,750. The warrants permit the holders to purchase
the underlying common shares at $4.31 per share, and are exercisable in whole at any time, or in part from time to time, for cash
or in a net share settlement, for seven years from the date of issuance. At December 31, 2012, all of these warrants remained
outstanding.



In February 2006, in conjunction with the
2006 Placement (see Note 5), the Company issued warrants for the purchase of 2,149,999 shares of its common stock. The allocated
aggregate fair value of these warrants was approximately $1.1 million. The warrants permitted the holders to purchase the underlying
common shares at $4.20 each and were exercisable in whole at any time, or in part from time to time, for cash, for five years
from the date of issuance. In addition, these warrants were redeemable at the Company’s option in the event that the volume
weighted average closing bid price of its common stock for any 20 consecutive trading days was at least $9.00 per share. These
warrants were scheduled to expire in February 2011 and, prior to that date, warrants for the purchase of 2,131,399 shares of common
stock had been exercised by the holders. The remaining warrants for the purchase of 18,600 share of common stock remained unexercised
and expired in February 2011.



The Company also issued warrants to its
placement agent for the 2006 Placement to purchase 716,666 shares of its common stock with an exercise price of 110% of the purchase
price per share based on shares sold in the 2006 Placement, or $3.30 per share and an aggregate fair value of approximately $705,000.
These warrants are exercisable in whole at any time, or in part from time to time, for cash or in a net share settlement, for
seven years from the date of issuance. At December 31, 2012, warrants for the purchase of 486,766 shares of the Company’s
stock remained outstanding. However, such warrants expired in February 2013.



In February 2005, in conjunction with and
as compensation for facilitating the Merger (see Note 1), the Company issued warrants for the purchase of 105,516 shares of its
common stock at an exercise price of approximately $2.62 per share. The aggregate fair value of these warrants was approximately
$26,700. These warrants were exercisable in whole at any time, or in part from time to time, for cash or in a net share settlement,
for seven years from the date of issuance. At December 31, 2012, all of these warrants had been exercised by the holders.



In December 2004, as compensation for fundraising
efforts related to the 2004 Placement (see Note 5), the Company issued warrants to purchase 483,701 shares of its common stock,
with a purchase price of 110% of the purchase price per share based on shares sold in the 2004 Placement, or, as converted under
terms of the Merger Agreement, approximately $2.89 per share. The aggregate fair value of these warrants was approximately $14,000.
The warrants permit the holders to purchase the underlying common shares at $2.88 per share, and were exercisable in whole at
any time, or in part from time to time, for cash or in a net share settlement, for seven years from the date of issuance. These
warrants were scheduled to expire in December 2011 and, prior to that date, all had been exercised by the holders.

F-23







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



NOTES TO CONSOLIDATED FINANCIAL STATEMENTS



Exercise of Common Stock Warrants



In February 2012, a warrant holder exercised
the right to purchase 57,000 shares of the common stock of the Company, with an exercise price of $3.30 per share, pursuant to
a cashless exercise whereby the Company, in a net share settlement, issued 17,148 shares of its common stock to the warrant holder
based on the excess of the market price over the exercise price on the date of exercise.



During January and February 2011, various
warrant holders exercised their rights to purchase an aggregate of 1,993,444 shares of the common stock of the Company, with an
exercise price of $4.20 per share, pursuant to cash exercises whereby the Company received proceeds of approximately $8.4 million.
In addition, in December 2011, a warrant holder exercised its right to purchase 37,277 shares of the common stock of the Company,
with an exercise price of approximately $2.89 per share, pursuant to a cash exercise whereby the Company received proceeds of
approximately $0.1 million.



During 2011, various warrant holders exercised
the rights to purchase 331,245 shares of the common stock of the Company, with exercise prices of $2.89 per share, pursuant to
cashless exercises whereby the Company, in net share settlements, issued 149,950 shares of its common stock to the various warrant
holders based on the excess of the market price over the exercise price on the dates of exercise.



During 2010, a warrant holder exercised
the right to purchase 26,379 shares of the common stock of the Company, with an exercise price of $2.62 per share, pursuant to
a cashless exercise whereby the Company, in a net share settlement, issued 14,298 shares of its common stock to the warrant holder
based on the excess of the market price over the exercise price on the date of exercise. Also in 2010, a warrant holder exercised
the right to purchase 1,058,236 shares of the common stock of the Company, with an exercise price of $2.79 per share, pursuant
to a cashless exercise whereby the Company, in a net share settlement, issued 661,930 shares of its common stock to the warrant
holder based on the excess of the market price over the exercise price on the date of exercise.



During 2010, various warrant holders exercised
their rights to purchase an aggregate of 65,555 shares of the common stock of the Company at an exercise price of $4.20 per share
pursuant to cash exercises whereby the Company recorded proceeds of approximately $275,000.



During 2009, various warrant holders exercised
rights to purchase 119,691 shares of the common stock of the Company, with an average exercise price of approximately $3.27 per
share, pursuant to cashless exercises whereby the Company, in net share settlements, issued 63,927 shares of its common stock
to the warrant holders based on the excess of the market price over the exercise price on the respective dates of exercise.



During 2008, various warrant holders, on
various dates, exercised rights to purchase 100,487 shares of the common stock of the Company, with an average exercise price
of approximately $2.91 per share, pursuant to cashless exercises whereby the Company, in net share settlements, issued 57,983
shares of its common stock to the warrant holders based on the excess of the market price over the exercise price on the respective
dates of exercise.



During 2008, various warrant holders, on
various dates, exercised rights to purchase 11,200 shares of the common stock of the Company at an exercise price of $4.20 per
share pursuant to a cash exercise whereby the Company recorded proceeds of $47,040.



During 2007, various warrant holders, on
various dates, exercised rights to purchase 116,596 shares of the common stock of the Company, with an average exercise price
of approximately $2.90 per share, pursuant to cashless exercises whereby the Company, in net share settlements, issued 68,136
shares of its common stock to the warrant holders based on the excess of the market prices over the exercise prices on the respective
dates of exercise.



During 2007, various warrant holders, on
various dates, exercised rights to purchase 61,200 shares of the common stock of the Company at an exercise price of $4.20 per
share pursuant to a cash exercise whereby the Company recorded cash proceeds, net of expenses, of $252,040.



During 2006, various warrant holders, on
various dates, exercised rights to purchase 30,422 shares of the Company’s common stock, with an exercise price of approximately
$2.89 per share, pursuant to cashless exercises whereby the Company, in net share settlements, issued 15,461 shares of its common
stock to the warrant holders based on the excess of the market prices over the exercise prices on the respective dates of exercise.



F-24







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



NOTES TO CONSOLIDATED FINANCIAL STATEMENTS



Stock Options



The Company has a stock incentive plan,
as amended (the “Plan”) under which incentive stock options for 10,400,000 shares of the Company’s common stock
may be granted. Grants under the Plan may be made to employees (including officers), directors, consultants, advisors or other
independent contractors who provide services to the Company or its subsidiary.



Options awards to employees and directors
are granted with an exercise price equal to or greater than the market price of the Company’s stock at the date of the grant
and generally have 10-year contractual terms.



During the years ended December 31, 2012,
2011 and 2010, the Company granted stock options to employees and non-employee directors as follows:



|                                       |  | For the years ended December 31, |          
|-------------------------------------- |  | -------------------------------- | ---------
|                                       |  | 2012                             |          
|Options granted during period          |  |                                  | 2,136,000
|Weighted average exercise price        |  | $                                | 3.26     
|Weighted average grant date fair value |  | $                                | 2.21     



The aggregate intrinsic value is calculated
as the difference between the exercise prices of the underlying awards and the quoted closing price of the common stock of the
Company as of December 31, 2012 for those awards that have an exercise price below the quoted closing price. There is no intrinsic
value for any of the options granted in 2012, 2011 and 2010 as the exercise prices of those options exceeded the quoted closing
price of the Company’s common stock on December 31, 2012. However, for all options outstanding at December 31, 2012, the
aggregate intrinsic value as of that date was approximately $48,900.



Each option granted to employees and non-employee
directors during 2012, 2011 and 2010 vests as to 25% of the shares on each of the first, second, third and fourth anniversary
of the vesting commencement date. Following the vesting periods, options are exercisable by employees until the earlier of 90
days after the employee’s termination with the Company or the ten-year anniversary of the initial grant, subject to adjustment
under certain conditions and at the discretion of the Board of Directors. Following the vesting periods, options are exercisable
by non-employee directors until the earlier of 180 days after they cease to be a member of the Board of Directors or the ten-year
anniversary of the initial grant, subject to adjustment under certain conditions and at the discretion of the Board of Directors.
As of January 2012, options that are forfeited or cancelled are not returned to the option pool and are, accordingly, no longer
eligible for grant under the Plan. Effective June 5, 2012, the Plan was amended to modify Section 5.2,
removing a sentence that could be interpreted as allowing repricing of options issued under the Plan.



During the years ended December 31, 2012,
2011 and 2010, options for 837,150, 40,000 and 12,000 shares were forfeited by former employees of the company.



F-25







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



NOTES TO CONSOLIDATED FINANCIAL STATEMENTS



A summary of the Company’s stock
option activity and related information since inception is as follows:



|                                 |  | Available |            |   | Activity/ |  |           | Wtd Avg        | 
|-------------------------------- |  | --------- | ---------- | - | --------- |  | --------- | -------------- | 
|                                 |  | For Grant |            |   | Balance   |  |           | Exercise Price | 
|Establish 2002 Option Plan       |  |           | 1,085,648  |   |           |  | -         |                | 
|Balance at December 31, 2002     |  |           | 1,085,648  |   |           |  | -         |                | 
|                                 |  |           |            |   |           |  |           |                | 
|2003 Activity                    |  |           | -          |   |           |  | -         |                | 
|Balance at December 31, 2003     |  |           | 1,085,648  |   |           |  | -         |                | 
|                                 |  |           |            |   |           |  |           |                | 
|Cancel 2002 Stock Option Plan    |  |           | (1,085,648 | ) |           |  | -         |                | 
|Establish 2004 Stock Option Plan |  |           | 1,085,648  |   |           |  | -         |                | 
|2004 Option grants               |  |           | (363,835   | ) |           |  | 363,835   |                | 
|Balance at December 31, 2004     |  |           | 721,813    |   |           |  | 363,835   |                | 
|                                 |  |           |            |   |           |  |           |                | 
|2005 Plan Amendment              |  |           | 410,784    |   |           |  | -         |                | 
|2005 Option grants               |  |           | (761,451   | ) |           |  | 761,451   |                | 
|2005 Cancellations               |  |           | 58,683     |   |           |  | (58,683   | )              | 
|2005 Exercises                   |  |           | -          |   |           |  | (14,663   | )              | 
|Balance at December 31, 2005     |  |           | 429,829    |   |           |  | 1,051,940 |                | 
|                                 |  |           |            |   |           |  |           |                | 
|2006 Plan Amendments             |  |           | 1,148,568  |   |           |  | -         |                | 
|2006 Option grants               |  |           | (668,085   | ) |           |  | 668,085   |                | 
|2006 Cancellations               |  |           | 8,802      |   |           |  | (8,802    | )              | 
|2006 Exercises                   |  |           | -          |   |           |  | (78,683   | )              | 
|Balance at December 31, 2006     |  |           | 919,114    |   |           |  | 1,632,540 |                | 
|                                 |  |           |            |   |           |  |           |                | 
|2007 Plan Amendments             |  |           | 1,500,000  |   |           |  | -         |                | 
|2007 Option grants               |  |           | (665,500   | ) |           |  | 665,500   |                | 
|2007 Exercises                   |  |           | -          |   |           |  | (17,868   | )              | 
|Balance at December 31, 2007     |  |           | 1,753,614  |   |           |  | 2,280,172 |                | 
|                                 |  |           |            |   |           |  |           |                | 
|2008 Option grants               |  |           | (837,500   | ) |           |  | 837,500   |                | 
|2008 Cancellations               |  |           | 148,802    |   |           |  | (148,802  | )              | 
|2008 Exercises                   |  |           | -          |   |           |  | (94,230   | )              | 
|Balance at December 31, 2008     |  |           | 1,064,916  |   |           |  | 2,874,640 |                | 
|                                 |  |           |            |   |           |  |           |                | 
|2009 Plan Amendments             |  |           | 855,000    |   |           |  | -         |                | 
|2009 Option grants               |  |           | (938,290   | ) |           |  | 938,290   |                | 
|Balance at December 31, 2009     |  |           | 981,626    |   |           |  | 3,812,930 |                | 
|                                 |  |           |            |   |           |  |           |                | 
|2010 Plan Amendments             |  |           | 1,200,000  |   |           |  | -         |                | 
|2010 Option grants               |  |           | (861,000   | ) |           |  | 861,000   |                | 
|2010 Cancellations               |  |           | 12,000     |   |           |  | (12,000   | )              | 
|Balance at December 31, 2010     |  |           | 1,332,626  |   |           |  | 4,661,930 |                | 
|                                 |  |           |            |   |           |  |           |                | 
|2011 Plan Amendments             |  |           | 1,200,000  |   |           |  | -         |                | 
|2011 Option grants               |  |           | (1,190,500 | ) |           |  | 1,190,500 |                | 
|2011 Cancellations               |  |           | 40,000     |   |           |  | (40,000   | )              | 
|Balance at December 31, 2011     |  |           | 1,382,126  |   |           |  | 5,812,430 |                | 
|                                 |  |           |            |   |           |  |           |                | 
|2012 Plan Amendments             |  |           | 3,000,000  |   |           |  | -         |                | 
|2012 Option grants               |  |           | (2,136,000 | ) |           |  | 2,136,000 |                | 
|2012 Exercises                   |  |           | -          |   |           |  | (35,210   | )              | 
|2012 Cancellations               |  |           | -          |   |           |  | (837,150  | )              | 
|Balance at December 31, 2012     |  |           | 2,246,126  |   |           |  | 7,076,070 |                | 



F-26







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



NOTES TO CONSOLIDATED FINANCIAL STATEMENTS



The table below summarizes options
outstanding, options vested and aggregate intrinsic value as of December 31, 2012:



|                                                       |  | Outstanding |           |  | Vested |  
|------------------------------------------------------ |  | ----------- | --------- |  | ------ | -
|Options under the Plan:                                |  |             |           |  |        |  
|Total options                                          |  |             | 7,076,070 |  |        |  
|Weighted average remaining contractual life (in years) |  |             | 6.27      |  |        |  
|Weighted average exercise price per share              |  | $           | 3.97      |  |        | $
|Aggregate intrinsic value of in-the-money options      |  | $           | 48,865    |  |        | $



During 2012, options for the purchase of
35,210 shares of the common stock of the Company were exercised at an exercise price of approximately $0.20 per share and an aggregate
intrinsic value at the date of exercise of approximately $44,900. During the years ended December 31, 2011 and 2010, no options
were exercised. The weighted average exercise price for all vested and unvested options outstanding as of December 31, 2012, 2011
and 2010 is approximately $3.97, $4.32 and $3.66 per share, respectively.



Common Stock Reserved for Future Issuance



Common stock reserved for future issuance
consists of the following:



|                                                 |  | December 31, |           
|------------------------------------------------ |  | ------------ | ----------
|                                                 |  | 2012         |           
|Common stock warrants outstanding                |  |              | 2,023,530 
|Common stock options outstanding                 |  |              | 7,076,070 
|Common stock options available for future grants |  |              | 2,246,126 
|                                                 |  |              | 11,345,726



At December 31, 2012, the Company had warrants
for the purchase of 2,023,530 shares of its common stock outstanding for which the warrant holders could elect a net share settlement.
As the market price as of December 31, 2012 exceeded the exercise prices of the warrants that ranged from $2.79 to $4.31 per share,
the Company would not have issued, in net share settlements, any shares of its common stock in settlement of these warrants.



8. Income Taxes



The Company does not have any
unrecognized tax benefits as it believes that all positions meet the more-likely-than-not recognition threshold, presuming
that such tax position would be examined by a relevant taxing authority that has full knowledge of all relevant information.
As such, a tabular presentation of those tax benefits is not presented.



From time to time, the Company may be assessed
interest or penalties by its tax jurisdictions, although, historically, there have been no such assessments and the Company believes
that any potential future assessments would be minimal and immaterial to the Company’s results of operations and financial
position. In the event the Company receives an assessment for interest and/or penalties, it would be classified in the consolidated
financial statements as general and administrative expense.



The Company and its subsidiaries file tax
returns in the United States and a small number of state jurisdictions. The statute of limitations for examination of the Company’s
returns has expired for years prior to 2009. There are no income tax examinations currently in process nor has the Company been
subject to examination since inception. The material jurisdictions subject to potential examination by taxing authorities for
open tax years primarily include the United States and the State of North Carolina.



The components of the deferred tax assets
and the valuation allowance are shown below. The state carryforwards are shown net of federal tax.



F-27







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



NOTES TO CONSOLIDATED FINANCIAL STATEMENTS



|                                                   |  | December 31, |            
|-------------------------------------------------- |  | ------------ | -----------
|                                                   |  | 2012         |            
|Deferred tax assets:                               |  |              |            
|Net operating loss carryforward - Federal          |  | $            | 65,898,904 
|Net operating loss carryforward - State            |  |              | 8,915,734  
|Licensing costs                                    |  |              | 1,213,928  
|Compensation costs and deferred stock compensation |  |              | 1,747,524  
|Inventory purchases prior to commercialization     |  |              | 2,671,034  
|Other temporary differences                        |  |              | (161,377   
|                                                   |  |              | 80,285,747 
|Less valuation allowance                           |  |              | (80,285,747
|                                                   |  | $            | -          



The reasons for the difference between
actual income tax benefit and the amount computed by applying the statutory federal income tax rate to the losses before income
tax benefit are as follows:



|                                               |  | December 31, |       
|---------------------------------------------- |  | ------------ | ------
|Rate reconciliation:                           |  | 2012         |       
|Statutory federal rate                         |  |              | -34.00
|State income tax rate (net of federal benefit) |  |              | -4.60 
|Certain non-deductible expenses                |  |              | 1.59  
|Effect of increase in valuation allowance      |  |              | 37.01 
|Effective tax rate                             |  |              | 0.00  



Given the Company’s history of incurring
operating losses, the Company’s ability to realize its deferred tax assets is not considered more likely than not. As a
result, a valuation allowance equal to the total deferred tax assets has been established. The valuation allowance as of December
31, 2012 and 2011 was approximately $80.3 million and $68.5 million, respectively.The increase in the valuation allowance during 2012 is primarily related to the increase in net operating losses.



At December 31, 2012, the Company had potentially
utilizable federal and state net operating loss carryforwards of approximately $193.8 million. The net operating loss carryforwards
expire in various amounts for federal and state tax purposes through 2032 and 2027, respectively.



Under limitations imposed by Internal Revenue
Code Section 382, or IRC§382, certain potential changes in ownership of the Company, which may be outside the Company’s
knowledge or control, may restrict future utilization of these NOL carryforwards. During 2011, the Company undertook, with the
assistance of its tax advisors, a detailed study in order to determine any potential IRC§382 limitations on its ability to
utilize, in future periods, its federal NOL carryforwards. This detailed study resulted in a determination that there had been
two ownership changes previously, as defined by IRC§382, limiting the Company’s NOLs available for federal tax purposes
to approximately $141.4 million at December 31, 2012. However, all NOLs would be available for use prior to their expiration,
resulting in no adjustment to the tax provision and disclosure at December 31, 2012. In future years, after utilizing the $141.4
million of NOLs currently available and any unrestricted future tax losses generated, the use of the remainder of the Company's
NOLs at December 31, 2012 would be limited to approximately $8.9 million annually for 2013, approximately $7.6 million for 2014,
approximately $4.1 million annually for the years from 2015 to 2022 and the remainder in 2023. Any portion of an NOL limited by
IRC§382 not used in a given year can be carried forward to subsequent years. Any NOLs generated during periods since the
date of the most recent ownership change and those that might be generated in any future periods can be used without restriction
unless a future ownership change occurs or has occurred since the date of our 2011 analysis.



Although the Company believes that
it is qualified for research and development tax credits, a detailed study has not been completed, as utilization of such credits is not available until the Company exhausts its available NOL carryforwards.
However, limitations
might be expected under Internal Revenue Code Section 383, or IRC§383, on the utilization of research and development
tax credits that may be available to the Company. The Company is currently unable to fully estimate the impact of any such
available research and development tax credits and any related IRC§383 limitations nor has it undertaken the steps
necessary to fully estimate the potential benefits that may be available to it from the utilization of research and
development tax credits in future periods.



F-28







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



NOTES TO CONSOLIDATED FINANCIAL STATEMENTS





In November 2010, the Company received
proceeds of approximately $488,000 for two grants awarded under the Qualifying Therapeutic Discovery Project Credit. These grants
were awarded to the Company for research and development efforts related to its two late-stage clinical programs and were classified
in the consolidated financial statements as a reduction in research and development expense.



9. Legal Proceedings



Following the receipt of the CRL from the FDA regarding the
NDA for NortheraTM (droxidopa) in March 2012 and the subsequent decline of the price of the Company’s common stock,
two purported class action lawsuits were filed on April 4, 2012 and another purported class action lawsuit was filed on May 1,
2012 in the U.S. District Court for the Western District of North Carolina against us and certain of our executive officers.



The complaints generally allege that, during differing class
periods, all of the defendants violated Sections 10(b) of the Exchange Act and Rule 10b-5 and the individual defendants violated
Section 20(a) of the Exchange Act in making various statements related to the Company’s development of Northera for
the treatment of symptomatic neurogenic OH and the likelihood of FDA approval. The complaints seek unspecified damages, interest,
attorneys’ fees, and other costs. Following consolidation of the three lawsuits and the appointment of a lead plaintiff,
a consolidated complaint was filed on October 5, 2012, on behalf of purchasers of the Company’s common stock from November
3, 2008 through March 28, 2012. The Company and its officers intend to vigorously defend against this lawsuit but are unable to
predict the outcome or reasonably estimate a range of possible loss at this time.



On May 2, 2012, a
purported shareholder derivative lawsuit was filed in the Delaware Court of Chancery against the members of the
Company’s board of directors as of the date of the lawsuit.  The complaint generally alleges that, from at least
June 2011 through February 2012, the defendants breached their fiduciary duties and otherwise caused harm to the Company in
connection with various statements related to the development of Northera for the treatment of Neurogenic OH and the
likelihood of FDA approval.  The complaint seeks unspecified damages, attorneys’ fees and other costs.  On
June 25, 2012, the Court of Chancery entered an Order staying the action until the U.S. District Court for the Western
District of North Carolina has ruled upon the motion to dismiss that the Company and its officers have filed on November 16,
2012 in response to the consolidated complaint in the class action. The Company intends to vigorously defend against this
lawsuit but is unable to predict the outcome or reasonably estimate a range of possible loss at this time.



10. Savings and Retirement Plan



During 2005, the Company established a
savings and retirement plan under Section 401(k) of the Internal Revenue Code that allows eligible employees to annually contribute
a portion of their annual salary to the plan. The Company matches such contributions up to a maximum of 4% of the employee's compensation,
as defined. For the years ended December 31, 2012, 2011 and 2010, the Company made contributions of approximately $196,000, $211,000
and $143,000, respectively.



11. Restructuring



In July 2012, the Company, at the direction
of its Board of Directors, initiated a corporate restructuring under which the number of employees were significantly reduced,
retaining only those employees necessary to continue the Company’s efforts to obtain marketing approval for Northera in
the United States. This reduction in force primarily, but not exclusively, impacted those positions that had been filled in 2011
and 2012 to support the planned commercialization of Northera in the United States. In addition, the Company’s Chief Executive
Officer, or CEO, and its Vice President of Sales and Marketing left the Company. The Company’s Vice President of Operations
was appointed interim President and CEO as the Board evaluates candidates for that position. At the Board level, the Chairman
of the Board stepped down, but remains a director while another existing director assumed the role of Chairman. The former CEO
and two other directors also resigned from the Board.



As a result of the significant headcount
reduction and given the increased workloads for those employees and directors that remain with the Company, the costs savings
initiatives announced on June 7, 2012 involving a 25% reduction in pay for all corporate executive officers and a similar reduction
in directors’ fees were terminated. Nearly all of the non-officers who were to have transitioned to part-time employment
pursuant to that costs savings initiative have been terminated as part of the reduction in force. Those non-officers remaining
with the Company that were to have transitioned to reduced schedules have been reinstated as full-time employees. The previously
announced suspension of 2012 performance bonuses for all employees remains in effect. A performance bonus program is expected
to be reestablished for 2013.



F-29







CHELSEA THERAPEUTICS INTERNATIONAL,
LTD. AND SUBSIDIARY

(A Development Stage Company)



NOTES TO CONSOLIDATED FINANCIAL STATEMENTS



Other than severance payments that continue
to be made to its former CEO and former Vice President of Sales and Marketing per the terms of their severance agreements, the
Company completed all other severance payments related to the reduction in force in the third quarter of 2012. As a component
of his departure, the Company accelerated the vesting of all unvested options that had been previously granted to its former CEO
and extended the period in which those options could be exercised from 90 days from the date of termination to two years from
that date. For the directors that resigned from the Board, the Company accelerated the vesting of all unvested options that had
been previously granted and extended the period in which those options can be exercised from 180 days from the date of separation
to one year from that date. For the former Vice President of Sales and Marketing, the Company agreed that options would continue
to vest and could be exercised until the end of his severance period plus 90 days. Given that all of these options were out of
the money as of the dates of the modifications, the impact of these exercise and vesting period modifications did not generate
any incremental stock-based compensation expense. However, as such modifications are considered to be a cancellation of the original
grants and the issuance of a new grant, adjustments were needed in order to true-up stock-based compensation expense recorded
for those options in 2012 based upon their adjusted fair value.



To assist in retention, the Board granted
the remaining executive officers options for the purchase of an aggregate of 350,000 shares of the common stock of the Company
on July 9, 2012. On July 23 and July 30, 2012, additional options were issued to the remaining members of the Board of Directors
for the purchase of an aggregate of 157,500 shares of the common stock of the Company. On August 15, 2012, options were granted
to the remaining employees in the Company for the purchase of an aggregate of 319,500 shares of the common stock of the Company.
In the aggregate, the Company issued options for the purchase of 827,000 shares of the common stock of the Company.



The Company recorded restructuring charges
associated with these actions during the year ended December 31, 2012 as follows:



|2012 Restructuring Activity      
|---------------------------------
|                                 
|                                 
|                                 
|                                 
|Employee related costs:          
|Severance and salary continuation
|Accrued vacation at separation   
|Related payroll taxes            
|Benefits                         
|Other costs                      
|Totals                           



| | (a) | – Approximately $150,000 of vacation expense had been
                                                                accrued and expensed in prior periods as the benefit was earned.
                                                                Upon announcement of the restructuring and the related reduction
                                                                in force, amounts accrued for those employees being terminated
                                                                was reclassified from accrued compensation and recorded as a component
                                                                of the restructuring reserve for balance sheet purposes. As such,
                                                                charges to the reserve, net of adjustments, does not directly
                                                                correspond to restructuring expenses reflected on the Consolidated
                                                                Condensed Statement of Operations.
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



12. Subsequent Events



Grant of Stock Options



Through March 7, 2013, the Company granted
options for the purchase of 785,500 shares of its common stock to employees and non-employee directors. These grants had a weighted
average exercise price of $0.93 per share, a weighted average fair value of $0.71 per share and were granted at an exercise price
equal to or greater than the closing market value of the Company’s stock on the dates of grant.



F-30