Master Label

Page 1 of 10

Dec. 4, 2012

MADEX Twin

Insecticidal Virus

Sublabel A: Agricultural Use 

Sublabel B: Residential Use

Active Ingredient*:

Cydia pomonella granulovirus isolate V22 0.06%

Other Ingredients: 99.94%

Total: 100.00%

*Contains a minimum of 3x1013viral occlusion bodies per liter.

KEEP OUT OF REACH OF CHILDREN

CAUTION

EPA Reg. No.: 69553-

EPA Est. No.: 

Manufactured by: Andermatt Biocontrol AG

Stahlermatten 6

CH-6146 Grossdietwil

Switzerland
Master Label

Page 2 of 10

Dec. 4, 2012

SUBLABEL A: Agricultural Use

MADEX Twin

Biological Insecticide for Control of the Codling Moth and Oriental Fruit Moth

Active Ingredient*:

Cydia pomonella granulovirus isolate V22 0.06%

Other Ingredients: 99.94%

Total: 100.00%

*Contains a minimum of 3x1013viral occlusion bodies per liter.

KEEP OUT OF REACH OF CHILDREN

CAUTION

SEE SIDE/INSIDE PANEL FOR ADDITIONAL PRECAUTIONARY STATEMENTS

Net Contents: 

Lot No.:

EPA Reg. No. 69553-

EPA Est. No. 

Manufactured by: Andermatt Biocontrol AG

Stahlermatten 6

CH-6146 Grossdietwil

Switzerland
Master Label

Page 3 of 10

Dec. 4, 2012

PRECAUTIONARY STATEMENTS

Hazards To Humans and Domestic Animals

CAUTION. Causes moderate eye and skin irritation. Avoid contact with skin, eyes or 

clothing. Wash thoroughly with soap and water after handling and before eating, 

drinking, chewing gum, using tobacco, or using the toilet. Remove and wash 

contaminated clothing before reuse.

PERSONAL PROTECTIVE EQUIPMENT (PPE)

Applicators and other handlers must wear: 

 long-sleeved shirt and long pants

 waterproof gloves

 shoes plus socks

Follow manufacturers’ instructions for cleaning/maintaining PPE. If no such 

instructions for washables exist, use detergent and hot water. Keep and 

wash PPE separately from other laundry.

Mixers/loaders and applicators must wear a dust/mist filtering respirator 

meeting NIOSH standards of at least N-95, R-95 or P-95. Repeated 

exposures to high concentrations of microbial proteins can cause allergic 

sensitization.

Engineering Controls

When handlers use closed systems or enclosed cabs in a manner that meet the 

requirements listed in the Worker Protection Standard (WPS) for agricultural 

pesticides [40 CFR 170.240(d)(4-6)], the handler PPE requirements may be 

reduced or modified as specified in the WPS.

IMPORTANT: When reduced PPE is worn because a closed system is being used, 

handlers must provide all PPE specified above for “applicators and other handlers” 

and have such PPE immediately available for use in an emergency, such as a spill 

or equipment breakdown.

FIRST AID

If in eyes:

 Hold eye open and rinse slowly and gently with water for 15-20 

minutes. Remove contact lenses, if present, after the first 5 

minutes, then continue rinsing.

 Call a poison control center or doctor for treatment advice.

If on skin:

 Take off contaminated clothing.

 Rinse skin immediately with plenty of water for 15-20 minutes.

 Call a poison control center or doctor for treatment advice.

HOT LINE NUMBER

Have the product container or label with you when calling a poison control center 

or doctor, or going for treatment. You may also contact the National Poison 

Control Hotline at 1-800-222-1222 for emergency medical treatment information.
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Page 4 of 10

Dec. 4, 2012

Environmental Hazards

For terrestrial uses: Do not apply directly to water, or to areas where surface water 

is present or to intertidal areas below the mean high water mark. Do not 

contaminate water when cleaning equipment or disposing of equipment wash 

waters or rinsate.

DIRECTIONS FOR USE

It is a violation of Federal law to use this product in a manner inconsistent with its 

labeling.

Do not apply this product in a way that will contact workers or other persons either 

directly or through drift. Only protected handlers may be in the area during 

application. For any requirements specific to your State or Tribe, consult the State 

or Tribal agency responsible for pesticide regulation.

Agricultural Use Requirements

Use this product only in accordance with its labeling and with the Worker Protection 

Standard, 40 CFR Part 170. This Standard contains requirements for the protection 

of agricultural workers on farms, forests, nurseries and greenhouses, and handlers 

of agricultural pesticides. It contains requirements for training, decontamination, 

notification, and emergency assistance. It also contains specific instructions and 

exceptions pertaining to the statements on this label about personal protective 

equipment (PPE), and restricted entry intervals (REI). The requirements in this box 

only apply to uses of this product that are covered by the Worker Protection 

Standard. 

Do not enter or allow worker entry into treated areas during the restricted entry 

interval (REI) of 4 hours unless wearing appropriate PPE.

PPE required for early entry to treated areas that is permitted under the Worker 

Protection Standard and that involves contact with anything that has been treated, 

such as plants, soil or water, is:

• Coveralls

• Waterproof gloves

• Shoes plus socks

USER SAFETY RECOMMENDATIONS

Users should wash hands before eating, drinking, chewing gum, using tobacco or 

using the toilet. Remove PPE immediately after handling this product. Wash the 

outside of gloves before removing. As soon as possible, wash thoroughly and 

change into clean clothing.
Master Label

Page 5 of 10

Dec. 4, 2012

GENERAL INFORMATION

MADEX Twin acts very specifically against larvae of the apple codling moth, Cydia 

pomonella, and the Oriental fruit moth, Grapholita molesta, as a pre-harvest 

biological insecticide on pome and stone fruit trees including apple, quince, pear, 

peach, nectarine, apricot, plum, cherry, walnut, almond, pluot, and aprium. After 

ingestion by the larva, the virus multiplies within the cells of the host insect causing 

a fatal infection. Rapid virus multiplication within the host cells results in cell 

destruction and death of the organism, typically within 3-7 days.

Start spraying shortly before larvae hatch from the eggs and before the larvae feed 

their way into the fruit. In general, one to two sprays per generation are generally 

sufficient. Due to unfavorable weather conditions, flight, egg laying, and hatching 

may extend over a longer period of time and up to 6 applications may be needed.

Frequent applications at low rates may be more effective than one or two applications at 

high rates.

Use Restriction

Do not apply this product through any type of irrigation system.

MIXING AND APPLICATION INSTRUCTIONS

Mix MADEX Twin with water and apply as a spray to fruit and foliage of 

trees in orchards and nurseries. Use water at or near neutral pH (7).

CROP RATE COMMENTS

Pome and 

Stone fruit 

trees 

including 

apple, 

quince, 

pear, 

peach, 

nectarine, 

apricot, 

plum,

prunes

cherry, 

walnut,

almond, 

pluot, and 

aprium 

0.5 - 3.0 fluid 

ounces per 

acre, 

depending on 

pest pressure

and application 

frequency.

Select a spray volume appropriate to tree size and density of 

foliage. For small trees use 50-100 gallons of water per acre. 

Larger trees with denser canopies require 100-200 gallons 

per acre.

Consult your local Cooperative Extension Service if you 

need advice about how to attain good spray coverage in 

your orchard.

Make at least two (2) applications of MADEX Twin per 

codling moth or Oriental fruit moth larval generation. Target 

small larvae early in their life cycle. Repeat as necessary to 

maintain control. MADEX Twin breaks down under direct 

exposure to sunlight. If moths are still flying and laying eggs, 

reapply after 6-8 sunny days (counting 2 partially sunny 

days as 1 sunny day).

MADEX Twin can be applied up to and including the day of harvest.
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Page 6 of 10

Dec. 4, 2012

STORAGE AND DISPOSAL

Do not contaminate water, food or feed by storage and disposal.

PESTICIDE STORAGE:

Store this product in original sealed container in a cool, dry place inaccessible to 

children and pets. Store at temperatures below 41°F (5°C). Bioactivity may be impaired 

by storage above 86°F (30°C). Storing the product under cold or freezing temperatures

will extend its shelf life.

PESTICIDE DISPOSAL:

To avoid wastes, use all material in this container by application according to label 

directions. If wastes cannot be avoided, offer remaining product to a waste disposal 

facility or pesticide disposal program (often such programs are run by state or local 

governments or by industry).

CONTAINER HANDLING:

Nonrefillable container. Do not reuse or refill this container. Triple rinse container (or 

equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining 

contents into application equipment or a mix tank and drain 10 seconds after the flow 

begins to drip. Fill the container 1/4 full with water and recap. Shake for 10 seconds. 

Pour rinsate into application equipment or a mix tank or store rinsate for later use or 

disposal. Drain for 10 seconds after the flow begins to drip. Repeat this procedure two 

more times. Then offer for recycling if available or puncture and dispose of in a sanitary 

landfill, or by incineration. Do not burn, unless allowed by State and local ordinances.

WARRANTY

Andermatt Biocontrol AG warrants that the material contained herein conforms to the 

description on the label and is reasonably fit for the purposes referred to in the 

directions for use. Timing and method of application, weather, watering practices, 

nature of soil, the insect problem, condition of the crop, incompatibility with other 

chemicals not specifically recommended and other influencing factors in the use of this 

product are beyond the control of the seller. To the extent consistent with applicable 

law, buyer assumes all risks of use, storage or handling of this material not in strict 

accordance with directions given herein. To the extent consistent with applicable law, 

NO OTHER EXPRESS OR IMPLIED WARRANTY OF THE FITNESS OR 

MERCHANTABILITY IS MADE.
Master Label

Page 7 of 10

Dec. 4, 2012

Sublabel B: Residential Use

MADEX Twin

Biological Insecticide for Control of the Codling Moth and Oriental Fruit Moth

Active Ingredient*:

Cydia pomonella granulovirus isolate V22 0.06%

Other Ingredients: 99.94%

Total: 100.00%

*Contains a minimum of 3x1013 viral occlusion bodies per liter.

KEEP OUT OF REACH OF CHILDREN

CAUTION

SEE SIDE/INSIDE PANEL FOR ADDITIONAL PRECAUTIONARY STATEMENTS

Net Contents: 

Lot No.:

EPA Reg. No. 69553-

EPA Est. No. 

Manufactured by: Andermatt Biocontrol AG

Stahlermatten 6

CH-6146 Grossdietwil

Switzerland
Master Label

Page 8 of 10

Dec. 4, 2012

PRECAUTIONARY STATEMENTS

Hazards To Humans and Domestic Animals

CAUTION. Causes moderate eye and skin irritation. Avoid contact with skin, eyes or 

clothing. Wash thoroughly with soap and water after handling and before eating, 

drinking, chewing gum, using tobacco, or using the toilet. Remove and wash 

contaminated clothing before reuse. When mixing and applying this product, wear a 

dust mask. Repeated exposures to high concentrations of microbial proteins can 

cause allergic sensitization.

ENVIRONMENTAL HAZARDS

To protect the environment, do not allow pesticide to enter or run off into storm drains, 

drainage ditches, gutters or surface waters. Applying this product in calm weather when 

rain is not predicted for the next 24 hours will help to ensure that wind or rain does not 

blow or wash pesticide off the treatment area. Rinsing application equipment over the 

treated area will help avoid run off to water bodies or drainage systems.

DIRECTIONS FOR USE

It is a violation of Federal law to use this product in a manner inconsistent with its 

labeling. 

GENERAL INFORMATION

MADEX Twin acts very specifically against larvae of the apple codling moth, Cydia 

pomonella, and the Oriental fruit moth, Grapholita molesta, as a pre-harvest 

biological insecticide on pome and stone fruit trees including apple, quince, pear, 

peach, nectarine, apricot, plum, cherry, walnut, almond, pluot, and aprium. After

ingestion by the larva, the virus multiplies within the cells of the host insect causing 

a fatal infection. Rapid virus multiplication within the host cells results in cell 

destruction and death of the organism, typically within 3-7 days. 

Start spraying shortly before larvae hatch from the eggs and before the larvae feed 

their way into the fruit. In general, one to two sprays per generation are generally 

sufficient. Due to unfavorable weather conditions, flight, egg laying, and hatching 

may extend over a longer period of time and up to 6 applications may be needed.

FIRST AID

If in eyes:

 Hold eye open and rinse slowly and gently with water for 15-20 

minutes. Remove contact lenses, if present, after the first 5 

minutes, then continue rinsing.

 Call a poison control center or doctor for treatment advice.

If on skin:

 Take off contaminated clothing.

 Rinse skin immediately with plenty of water for 15-20 minutes.

 Call a poison control center or doctor for treatment advice.

HOT LINE NUMBER

Have the product container or label with you when calling a poison control center 

or doctor, or going for treatment. You may also contact the National Poison 

Control Hotline at 1-800-222-1222 for emergency medical treatment information.
Master Label

Page 9 of 10

Dec. 4, 2012

Use Restrictions

For use only on pome and stone fruit trees in residential settings. Not for use on trees or 

fruit grown for sale or other commercial use.

MIXING AND APPLICATION INSTRUCTIONS

MADEX Twin must be mixed with water and applied as a spray to the fruit and 

foliage of pome and stone fruit trees (apple, quince, pear, peach, nectarine, 

apricot, plum, cherry, walnut, and almond).

Mix 1/2 teaspoon of MADEX Twin per 5 gallons of water and apply directly to each 

tree using a hand pump sprayer or other suitable spray equipment. Spray a 

sufficient volume to thoroughly wet all leaves and fruit with minimal run-off or 

dripping. 

Apply MADEX Twin first in late spring or early summer, when eggs of the first 

generation of codling moth or Oriental fruit moth begin to hatch. Apply MADEX Twin 

at least twice during each larval generation. When pest pressure persists, make 

additional applications of MADEX Twin in mid- to late summer. Consult your local 

Cooperative Extension Service for more information about the best timing of 

codling moth and Oriental fruit moth sprays.

MADEX Twin breaks down under direct exposure to-sunlight. If moths are still flying

and laying eggs, reapply after 6-8 sunny days (counting 2 partially sunny days as 1 

sunny day).

STORAGE AND DISPOSAL

Do not contaminate water, food, or feed by storage and disposal.

PESTICIDE STORAGE:

Keep in original container. Store away from direct sunlight, feed, or foodstuffs. 

Keep container tightly sealed when not in use. Store at temperatures below 41°F

(5°C). Bioactivity may be impaired by storage above 86°F (30°C). Storing the product 

under cold or freezing temperatures will extend its shelf life.

PESTICIDE DISPOSAL AND CONTAINER HANDLING:

Non-refillable container. Do not reuse or refill container.

If empty:

Place in trash or offer for recycling, if available.

If partly filled:

Call your local solid waste agency for disposal instructions. Never place unused 

product down any indoor or outdoor drain.
Master Label

Page 10 of 10

Dec. 4, 2012

WARRANTY

Andermatt Biocontrol AG warrants that the material contained herein conforms to 

the description on the label and is reasonably fit for the purposes referred to in the 

directions for use. Timing and method of application, weather, watering practices, 

nature of soil, the insect problem, condition of the crop, incompatibility with other 

chemicals not specifically recommended and other influencing factors in the use of 

this product are beyond the control of the seller. To the extent consistent with 

applicable law, buyer assumes all risks of use, storage or handling of this material 

not in strict accordance with directions given herein. To the extent consistent with 

applicable law, NO OTHER EXPRESS OR IMPLIED WARRANTY OF THE 

FITNESS OR MERCHANTABILITY IS MADE.