Clopyralid Dietary Exposure and Risk Assessment

PC Code: 117401/117403 DP Number: D399390

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF CHEMICAL SAFETY 

AND POLLUTION PREVENTION

MEMORANDUM

Date: 6/6/2012

SUBJECT: Clopyralid Chronic Aggregate Dietary (Food and Drinking Water) Exposure and 

Risk Assessment for the Section 3 Registration Action on Apples, Teff, the Leafy

Brassica Greens Subgroup (5-B), and the Rapeseed Subgroup (20-A)

PC Codes: 117403 (acid)

 117401 (alkanolamine salts)

DP Barcode: D399390

Decision No.: 450262 Registration Nos.: 62719-73, 62719-80, 62719-81, 

and 62719-84 

Petition No.: 1E7882 Regulatory Action: Section 3 Registration

Risk Assessment Type: Dietary Case No.: NA

TXR No.: NA CAS No.: 1702-17-6 (acid)

57754-85-5 (monoethanolamine salt)

MRID No.: NA 40 CFR: 180.431

 

FROM: Douglas Dotson, Ph.D., Chemist

Risk Assessment Branch II

Health Effects Division (7509P)

THROUGH: Meheret Negussie, Chemist

Dennis McNeilly, Chemist

Dietary Exposure Science Advisory Council (DESAC)

TO: Laura Nollen/Barbara Madden, RM Team 5

RIMUERB

Registration Division (7505P)

Executive Summary

A chronic dietary (food + drinking water) exposure and risk assessment was conducted for the 

herbicide clopyralid using the Dietary Exposure Evaluation Model DEEM-FCIDTM, Version 2.03 
Clopyralid Dietary Exposure and Risk Assessment

PC Code: 117401/117403 DP Number: D399390

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which uses food consumption data from the U.S. Department of Agriculture’s Continuing 

Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 1998. The analyses were 

performed to support Section 3 requests for the use of clopyralid on apples, teff, the Brassica 

leafy greens subgroup (Subgroup 5-B), and the rapeseed subgroup (Subgroup 20-A), except gold 

of pleasure.

The assessment is highly conservative with regard to protecting human health. The assessment

is based on tolerance-level residues for all commodities and the assumption that 100% of all 

commodities with tolerances will be treated (i.e., 100% crop treated). In addition, DEEM 

(Version 7.81) default processing factors were used for all processed commodities for which they

were available. Modeled estimates of clopyralid residues in drinking water were incorporated 

into the analyses. The general U.S. population uses 9.3% of the chronic population-adjusted 

dose (cPAD). The population subgroup Children 1-2 years old is estimated to have the highest 

dietary exposure to clopyralid. This subgroup uses 25% of the cPAD. Generally, HED is 

concerned about dietary risk when the exposure estimate exceeds 100% of the PAD. The 

combined dietary risk from exposure to residues of clopyralid in food and drinking water are not

of concern for the U.S. population or any of the population groups.

There is no acute dietary endpoint for clopyralid. As a result, an acute dietary exposure 

assessment was not conducted for the chemical. Clopyralid is classified as “not likely to be 

carcinogenic to humans.” As a result, quantification of cancer risk is not required.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to the 

point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety 

factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk exceeds one 

in one million. References which discuss the acute and chronic risk assessments in more detail 

are available on the EPA/pesticides web site: “Available Information on Assessing Exposure 

from Pesticides, A User’s Guide,” 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/EPAPEST/2000/July/Day-12/6061.pdf ; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for clopyralid was conducted by M. Doherty (D368855, 

10/27/2009).

II. Residue Information

This chronic dietary exposure assessment is based on tolerance-level residues for all 

commodities. Tolerances are established for residues of clopyralid in/on a wide variety of plant 

commodities at levels ranging from 0.5 ppm in/on stone fruits and the Bushberry subgroup (13-
Clopyralid Dietary Exposure and Risk Assessment

PC Code: 117401/117403 DP Number: D399390

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07B) to 500 ppm in/on grass forage and hay [40 CFR §180.431(a)]. Tolerances are also 

established for residues of clopyralid in livestock commodities at levels ranging from 0.1 ppm in 

eggs to 36 ppm in meat byproducts, except liver, of cattle, goats, horses and sheep. There

currently are no tolerances for inadvertent or indirect residues of clopyralid. The residue of 

concern for both tolerance enforcement and risk assessment is the parent compound only.

The Interregional Project No. 4 (IR-4) submitted a petition proposing the use of clopyralid on 

apples, Brassica leafy greens (Subgroup 5-B), and rapeseed (Subgroup 20-A) except gold of 

pleasure. In addition, IR-4 intends to submit a tolerance petition for the use of clopyralid on teff. 

The only study that IR-4 submitted in support of the current petition was a combined field 

trial/processing study for apples. The recommended tolerance for apple is 0.05 ppm. For the 

other commodities, IR-4 is proposing that currently established tolerances be extended to the 

proposed commodities. A tolerance of 5.0 ppm is established for mustard greens. IR-4 is 

proposing that this tolerance be extended to the Brassica leafy greens subgroup. A tolerance of 

3.0 ppm is established for canola seed. IR-4 is proposing that this tolerance be extended to 

rapeseed (Subgroup 20-A) except gold of pleasure. The following tolerances are established for 

wheat and barley commodities: 3.0 ppm for grain, 9.0 ppm for straw, 9.0 ppm for forage (wheat 

only), and 9.0 ppm for hay (barley only). IR-4 is proposing that these tolerances be extended to 

teff commodities. These requested uses do not impact existing tolerances for livestock 

commodities. Table 1 provides a summary of the recommended tolerances.

Table 1. Recommended Tolerances

Commodity Recommended Tolerance

(ppm)

Apple 0.05

Leafy Brassica Greens, Subgroup 5-B 5.0

Rapeseed, Subgroup 20-A, Except Gold of Pleasure 3.0

Teff, Grain 3.0

 

III. Percent Crop Treated Information

The assessment is based on the assumption that 100% of all commodities with established or 

proposed tolerances will be treated. 

IV. Drinking Water Data

The estimated drinking water concentrations (EDWCs) used in the dietary risk assessment were 

provided by the Environmental Fate and Effects Division (EFED) in the following 

memorandum: “Tier I Drinking Water Assessment for Proposed New Use of Clopyralid on 

Apple, Leafy Brassica Greens Subgroup 5B, and Rapeseed Subgroup 20A, except Camelina 

(Gold of Pleasure)” (D391398, W. Shaughnessy, 12/19/2011) and incorporated directly into this 

dietary assessment. Water residues were incorporated in the DEEM-FCID into the food 

categories “water, direct, all sources” and “water, indirect, all sources.” 
Clopyralid Dietary Exposure and Risk Assessment

PC Code: 117401/117403 DP Number: D399390

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A modeled estimate of the surface water concentration from the FQPA Index Reservoir 

Screening Tool (FIRST) Model was used for the assessment (Table 2). This value is 11.9 ppb. 

This estimate is greater than that for groundwater from the Screening Concentration in Ground 

Water (SCIGROW) Model. The same value was used in the previous dietary exposure 

assessment. The drinking water models and their descriptions are available at the EPA internet 

site: http://www.epa.gov/oppefed1/models/water/. 

Table 2. Maximum Tier 1 Estimated Drinking Water Concentrations

Drinking Water Source Model Used and Rate EDWC (ppb)

Groundwater NAWQA (Oregon) 0.2588

Surface Water (Acute) FIRST (non-food crop, one application per year 

@ 0.5 lb ai/A)

45

Surface Water (Chronic) FIRST (non-food crop, one application per year 

@ 0.5 lb ai/A)

11.9

V. DEEM-FCIDTM Program and Consumption Information

The clopyralid chronic dietary exposure assessment was conducted using the Dietary Exposure 

Evaluation Model software with the Food Commodity Intake Database DEEM-FCIDTM, Version 

2.03 which incorporates consumption data from USDA’s Continuing Surveys of Food Intakes by

Individuals (CSFII), 1994-1996 and 1998. The 1994-96, 98 data are based on the reported 

consumption of more than 20,000 individuals over two non-consecutive survey days. Foods “as 

consumed” (e.g., apple pie) are linked to EPA-defined food commodities (e.g. apples, peeled 

fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly 

available recipe translation files developed jointly by USDA/ARS and EPA. For chronic 

exposure assessment, consumption data are averaged for the entire U.S. population and within 

population subgroups, but for acute exposure assessment are retained as individual consumption 

events. Based on analysis of the 1994-96, 98 CSFII consumption data, which took into account 

dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk 

for the following population subgroups: the general U.S. population, all infants (<1 year old), 

children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 

50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup.
Clopyralid Dietary Exposure and Risk Assessment

PC Code: 117401/117403 DP Number: D399390

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VI. Toxicological Information

The toxicology database for clopyralid is incomplete at this time. Based on the toxicology data 

requirements outlined in the recently revised 40 CFR Part 158, there are additional requirements 

for acute and subchronic neurotoxicity studies in the rat (§870.6200a and b), and an 

immunotoxicity study (§870.7800). In addition, a 28-day inhalation toxicity study in the rat 

(§870.3465) is required. Nevertheless, HED recommends reduction of the FQPA Safety Factor 

to 1x. There was no evidence of increased pre- and/or postnatal qualitative or quantitative 

susceptibility in the developmental rat or rabbit studies, or the rat 2-generation reproduction 

study. In the developmental rat study, no developmental effects were seen in at a dose that 

caused maternal toxicity. Although acute and subchronic neurotoxicity studies and an 

immunotoxicity study have not been submitted and are required under the revised 40 CFR Part 

158 guidelines, the available subchronic and chronic studies show no evidence of either 

neurotoxicity or immunotoxicity at doses up to or exceeding the limit dose. The endpoints 

selected for risk assessment are therefore considered adequately protective of pre- and/or 

postnatal toxicity. The endpoints selected for use in dietary risk assessment are summarized in 

Table 3, below.

Table 3. Toxicological Doses and Endpoints for Clopyralid for Use in Dietary Human Health Risk 

Assessments

Exposure/

Scenario

Point of 

Departure

Uncertainty/FQPA 

Safety Factors

Level of Concern for 

Risk Assessment

Study and Toxicological Effects

Acute Dietary 

(All populations 

including infants 

and children) 

NA NA NA There is no effect attributable to a 

single dose. As a result, an acute 

dietary endpoint was not selected.

Chronic Dietary

(All populations

including infants 

and children)

NOAEL= 

15 mg/kg/day 

UFA= 10x

UFH= 10x

SFFQPA=1

cRfD=

0.15 mg/kg/day

cPAD=

0.15 mg/kg/day

2-Year Combined Chronic

Toxicity/Carcinogenicity (oral) – rat

LOAEL = 150 mg/kg/day, based on 

increased epithelial hyperplasia and 

thickening of the limiting ridge of the 

stomach in both sexes.

Cancer Classified as “Not likely to be carcinogenic to humans.” Quantification of cancer risk is not 

required.

Point of Departure = A data point or an estimated point that is derived from observed dose-response data and used to mark the 

beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no 

observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UFA = extrapolation 

from animal to human (interspecies). UFH = potential variation in sensitivity among members of the human population 

(intraspecies). FQPA SF = FQPA Safety Factor. c PAD = chronic population adjusted dose. RfD = reference dose. N/A = not 

applicable.

VII. Results 

As stated above, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEMFCIDTM analyses estimate the dietary exposure of the U.S. population and various population 

subgroups. The results reported in Table 4 are for the general U.S. Population, all infants (<1 

year old), children 1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, 
Clopyralid Dietary Exposure and Risk Assessment

PC Code: 117401/117403 DP Number: D399390

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and adults 50+ years. Risk estimates are not of concern for the general U.S. population or any of 

the population subgroups. The general U.S. population uses 9.3% of the cPAD. The most 

highly exposed population subgroup, Children 1-2 years old, uses 25% of the cPAD.

Table 4. Summary of the Combined Dietary (Food + Drinking Water) Exposure and Risk Estimates for 

Clopyralid

Population Subgroup

Acute Chronic Cancer

Dietary Exposure 

(mg/kg/day)

% 

aPAD*

Dietary Exposure

(mg/kg/day) % cPAD*

Dietary Exposure

(mg/kg/day) Risk

General U.S. Population

NA NA

0.013895 9.3

N/A N/A

All Infants (< 1 year old) 0.013726 9.2

Children 1-2 years old 0.037039 25

Children 3-5 years old 0.033869 23

Children 6-12 years old 0.022590 15

Youth 13-19 years old 0.013383 8.9

Adults 20-49 years old 0.010847 7.2

Adults 50+ years old 0.009407 6.3

Females 13-49 years old 0.010170 6.8

The values for the highest exposed population subgroup are bolded.

VIII. Characterization of Inputs/Outputs

HED considers the chronic dietary exposure assessment to be very conservative. It is based on 

tolerance-level residues for all commodities. Conservative processing factors (DEEM default) 

were used for all processed commodities. In addition, it is assumed that 100% of all crops with 

registered or proposed will be treated. The EDWCs were also conservative. As all risk estimates 

are not of concern, it is not necessary to make any refinements to the dietary exposure 

assessment. 

IX. Conclusions

The exposure estimates that were generated are very conservative estimates of the actual dietary

exposures that might occur. The aggregate (food + water) dietary risk estimates are below 

HED’s level of concern for all population subgroups. HED is confident that the dietary exposure 

assessment does not underestimate risk to the general U.S. population or any population 

subgroup.

List of Attachments

Attachment 1. Chronic Residue Input File

Attachment 2. Results of Chronic Dietary Exposure Analysis
Clopyralid Dietary Exposure and Risk Assessment

PC Code: 117401/117403 DP Number: D399390

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Attachment 1: Chronic Residue Input File

Chronic NOAEL: 15 mg/kg bw/day

Chronic PAD: 0.15 mg/kg bw/day 

DEEM-FCID Program Version 2.03

Filename: C:\Documents and Settings\ddotson\My Documents\Deemfcid\Clopyralid\

ClopyralidChronic2.R98

Date created/last modified: 03-02-2012/16:56:18/8

--------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

01010500 1AB Beet, garden, roots 4.000000 1.000 1.000 

01010501 1AB Beet, garden, roots-babyfood 4.000000 1.000 1.000 

01010520 1A Beet, sugar 2.000000 1.000 1.000 

01010521 1A Beet, sugar-babyfood 2.000000 1.000 1.000 

01010530 1A Beet, sugar, molasses 10.000000 1.000 1.000 

01010531 1A Beet, sugar, molasses-babyfood 10.000000 1.000 1.000 

01013880 1AB Turnip, roots 1.000000 1.000 1.000 

02000510 2 Beet, garden, tops 3.000000 1.000 1.000 

04013550 4A Spinach 5.000000 1.000 1.000 

04013551 4A Spinach-babyfood 5.000000 1.000 1.000 

04023670 4B Swiss chard 3.000000 1.000 1.000 

05010610 5A Broccoli 2.000000 1.000 1.000 

05010611 5A Broccoli-babyfood 2.000000 1.000 1.000 

05010620 5A Broccoli, Chinese 2.000000 1.000 1.000 

05010640 5A Brussels sprouts 2.000000 1.000 1.000 

05010690 5A Cabbage 2.000000 1.000 1.000 

05010710 5A Cabbage, Chinese, napa 2.000000 1.000 1.000 

05010720 5A Cabbage, Chinese, mustard 2.000000 1.000 1.000 

05010830 5A Cauliflower 2.000000 1.000 1.000 

05011960 5A Kohlrabi 2.000000 1.000 1.000 

05020630 5B Broccoli raab 5.000000 1.000 1.000 1E7882

05020700 5B Cabbage, Chinese, bok choy 5.000000 1.000 1.000 1E7882

05021170 5B Collards 5.000000 1.000 1.000 1E7882

05021940 5B Kale 5.000000 1.000 1.000 1E7882

05022290 5B Mustard greens 5.000000 1.000 1.000 1E7882

05023180 5B Rape greens 5.000000 1.000 1.000 1E7882

05023890 5B Turnip, greens 4.000000 1.000 1.000 1E7882

11000070 11 Apple, fruit with peel 0.050000 1.000 1.000 1E7882

11000080 11 Apple, peeled fruit 0.050000 1.000 1.000 1E7882

11000081 11 Apple, peeled fruit-babyfood 0.050000 1.000 1.000 1E7882

11000090 11 Apple, dried 0.050000 8.000 1.000 1E7882

11000091 11 Apple, dried-babyfood 0.050000 8.000 1.000 1E7882

11000100 11 Apple, juice 0.050000 1.300 1.000 1E7882

11000101 11 Apple, juice-babyfood 0.050000 1.300 1.000 1E7882

11000110 11 Apple, sauce 0.050000 1.000 1.000 1E7882

11000111 11 Apple, sauce-babyfood 0.050000 1.000 1.000 1E7882

12000120 12 Apricot 0.500000 1.000 1.000 

12000121 12 Apricot-babyfood 0.500000 1.000 1.000 

12000130 12 Apricot, dried 0.500000 6.000 1.000 

12000140 12 Apricot, juice 0.500000 1.000 1.000 

12000141 12 Apricot, juice-babyfood 0.500000 1.000 1.000 

12000900 12 Cherry 0.500000 1.000 1.000 

12000901 12 Cherry-babyfood 0.500000 1.000 1.000 

12000910 12 Cherry, juice 0.500000 1.500 1.000 
Clopyralid Dietary Exposure and Risk Assessment

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12000911 12 Cherry, juice-babyfood 0.500000 1.500 1.000 

12002300 12 Nectarine 0.500000 1.000 1.000 

12002600 12 Peach 0.500000 1.000 1.000 

12002601 12 Peach-babyfood 0.500000 1.000 1.000 

12002610 12 Peach, dried 0.500000 7.000 1.000 

12002611 12 Peach, dried-babyfood 0.500000 7.000 1.000 

12002620 12 Peach, juice 0.500000 1.000 1.000 

12002621 12 Peach, juice-babyfood 0.500000 1.000 1.000 

12002850 12 Plum 0.500000 1.000 1.000 

12002851 12 Plum-babyfood 0.500000 1.000 1.000 

12002860 12 Plum, prune, fresh 0.500000 1.000 1.000 

12002861 12 Plum, prune, fresh-babyfood 0.500000 1.000 1.000 

12002870 12 Plum, prune, dried 1.500000 1.000 1.000 

12002871 12 Plum, prune, dried-babyfood 1.500000 1.000 1.000 

12002880 12 Plum, prune, juice 0.500000 1.400 1.000 

12002881 12 Plum, prune, juice-babyfood 0.500000 1.400 1.000 

13020570 13B Blueberry 0.500000 1.000 1.000 

13020571 13B Blueberry-babyfood 0.500000 1.000 1.000 

13021360 13B Currant 0.500000 1.000 1.000 

13021490 13B Elderberry 0.500000 1.000 1.000 

13021740 13B Gooseberry 0.500000 1.000 1.000 

13021910 13B Huckleberry 0.500000 1.000 1.000 

15000250 15 Barley, pearled barley 12.000000 1.000 1.000 

15000251 15 Barley, pearled barley-babyfood 12.000000 1.000 1.000 

15000260 15 Barley, flour 3.000000 1.000 1.000 

15000261 15 Barley, flour-babyfood 3.000000 1.000 1.000 

15000270 15 Barley, bran 12.000000 1.000 1.000 

15001200 15 Corn, field, flour 1.000000 1.000 1.000 

15001201 15 Corn, field, flour-babyfood 1.000000 1.000 1.000 

15001210 15 Corn, field, meal 1.000000 1.000 1.000 

15001220 15 Corn, field, bran 1.000000 1.000 1.000 

15001230 15 Corn, field, starch 1.000000 1.000 1.000 

15001231 15 Corn, field, starch-babyfood 1.000000 1.000 1.000 

15001240 15 Corn, field, syrup 1.000000 1.500 1.000 

15001241 15 Corn, field, syrup-babyfood 1.000000 1.500 1.000 

15001250 15 Corn, field, oil 1.000000 1.000 1.000 

15001251 15 Corn, field, oil-babyfood 1.000000 1.000 1.000 

15001260 15 Corn, pop 1.000000 1.000 1.000 

15001270 15 Corn, sweet 1.000000 1.000 1.000 

15001271 15 Corn, sweet-babyfood 1.000000 1.000 1.000 

15002310 15 Oat, bran 3.000000 1.000 1.000 

15002320 15 Oat, flour 3.000000 1.000 1.000 

15002321 15 Oat, flour-babyfood 3.000000 1.000 1.000 

15002330 15 Oat, groats/rolled oats 3.000000 1.000 1.000 

15002331 15 Oat, groats/rolled oats-babyfood 3.000000 1.000 1.000 

15003810 15 Triticale, flour 3.000000 1.000 1.000 

15004010 15 Wheat, grain 3.000000 1.000 1.000 

15004011 15 Wheat, grain-babyfood 3.000000 1.000 1.000 

15004020 15 Wheat, flour 3.000000 1.000 1.000 

15004021 15 Wheat, flour-babyfood 3.000000 1.000 1.000 

15004030 15 Wheat, germ 12.000000 1.000 1.000 

15004040 15 Wheat, bran 12.000000 1.000 1.000 

20001630 20 Flaxseed, oil 3.000000 1.000 1.000 1E7882

20003190 20 Rapeseed, oil 3.000000 1.000 1.000 1E7882

20003191 20 Rapeseed, oil-babyfood 3.000000 1.000 1.000 1E7882

21000440 M Beef, meat 1.000000 1.000 1.000 

21000441 M Beef, meat-babyfood 1.000000 1.000 1.000 

21000450 M Beef, meat, dried 1.000000 1.920 1.000 

21000460 M Beef, meat byproducts 36.000000 1.000 1.000 

21000461 M Beef, meat byproducts-babyfood 36.000000 1.000 1.000 

21000470 M Beef, fat 1.000000 1.000 1.000 

21000471 M Beef,fat-babyfood 1.000000 1.000 1.000 

21000480 M Beef, kidney 36.000000 1.000 1.000 
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21000490 M Beef, liver 3.000000 1.000 1.000 

21000491 M Beef, liver-babyfood 3.000000 1.000 1.000 

23001690 M Goat, meat 1.000000 1.000 1.000 

23001700 M Goat, meat byproducts 36.000000 1.000 1.000 

23001710 M Goat, fat 1.000000 1.000 1.000 

23001720 M Goat, kidney 36.000000 1.000 1.000 

23001730 M Goat, liver 3.000000 1.000 1.000 

24001890 M Horse, meat 1.000000 1.000 1.000 

25002900 M Pork, meat 0.200000 1.000 1.000 

25002901 M Pork, meat-babyfood 0.200000 1.000 1.000 

25002910 M Pork, skin 0.200000 1.000 1.000 

25002920 M Pork, meat byproducts 0.200000 1.000 1.000 

25002921 M Pork, meat byproducts-babyfood 0.200000 1.000 1.000 

25002930 M Pork, fat 0.200000 1.000 1.000 

25002931 M Pork, fat-babyfood 0.200000 1.000 1.000 

25002940 M Pork, kidney 0.200000 1.000 1.000 

25002950 M Pork, liver 0.200000 1.000 1.000 

26003390 M Sheep, meat 1.000000 1.000 1.000 

26003391 M Sheep, meat-babyfood 1.000000 1.000 1.000 

26003400 M Sheep, meat byproducts 36.000000 1.000 1.000 

26003410 M Sheep, fat 1.000000 1.000 1.000 

26003411 M Sheep, fat-babyfood 1.000000 1.000 1.000 

26003420 M Sheep, kidney 36.000000 1.000 1.000 

26003430 M Sheep, liver 3.000000 1.000 1.000 

27002220 D Milk, fat 0.200000 1.000 1.000 

27002221 D Milk, fat - baby food/infant for 0.200000 1.000 1.000 

27012230 D Milk, nonfat solids 0.200000 1.000 1.000 

27012231 D Milk, nonfat solids-baby food/in 0.200000 1.000 1.000 

27022240 D Milk, water 0.200000 1.000 1.000 

27022241 D Milk, water-babyfood/infant form 0.200000 1.000 1.000 

27032251 D Milk, sugar (lactose)-baby food/ 0.200000 1.000 1.000 

40000930 P Chicken, meat 0.200000 1.000 1.000 

40000931 P Chicken, meat-babyfood 0.200000 1.000 1.000 

40000940 P Chicken, liver 0.200000 1.000 1.000 

40000950 P Chicken, meat byproducts 0.200000 1.000 1.000 

40000951 P Chicken, meat byproducts-babyfoo 0.200000 1.000 1.000 

40000960 P Chicken, fat 0.200000 1.000 1.000 

40000961 P Chicken, fat-babyfood 0.200000 1.000 1.000 

40000970 P Chicken, skin 0.200000 1.000 1.000 

40000971 P Chicken, skin-babyfood 0.200000 1.000 1.000 

50003820 P Turkey, meat 0.200000 1.000 1.000 

50003821 P Turkey, meat-babyfood 0.200000 1.000 1.000 

50003830 P Turkey, liver 0.200000 1.000 1.000 

50003831 P Turkey, liver-babyfood 0.200000 1.000 1.000 

50003840 P Turkey, meat byproducts 0.200000 1.000 1.000 

50003841 P Turkey, meat byproducts-babyfood 0.200000 1.000 1.000 

50003850 P Turkey, fat 0.200000 1.000 1.000 

50003851 P Turkey, fat-babyfood 0.200000 1.000 1.000 

50003860 P Turkey, skin 0.200000 1.000 1.000 

50003861 P Turkey, skin-babyfood 0.200000 1.000 1.000 

60003010 P Poultry, other, meat 0.200000 1.000 1.000 

60003020 P Poultry, other, liver 0.200000 1.000 1.000 

60003030 P Poultry, other, meat byproducts 0.200000 1.000 1.000 

60003040 P Poultry, other, fat 0.200000 1.000 1.000 

60003050 P Poultry, other, skin 0.200000 1.000 1.000 

70001450 P Egg, whole 0.100000 1.000 1.000 

70001451 P Egg, whole-babyfood 0.100000 1.000 1.000 

70001460 P Egg, white 0.100000 1.000 1.000 

70001461 P Egg, white (solids)-babyfood 0.100000 1.000 1.000 

70001470 P Egg, yolk 0.100000 1.000 1.000 

70001471 P Egg, yolk-babyfood 0.100000 1.000 1.000 

86010000 O Water, direct, all sources 0.011900 1.000 1.000 

86020000 O Water, indirect, all sources 0.011900 1.000 1.000 
Clopyralid Dietary Exposure and Risk Assessment

PC Code: 117401/117403 DP Number: D399390

Page 10 of 11

95000190 O Asparagus 1.000000 1.000 1.000 

95001300 O Cranberry 4.000000 1.000 1.000 

95001301 O Cranberry-babyfood 4.000000 1.000 1.000 

95001310 O Cranberry, dried 4.000000 1.000 1.000 

95001320 O Cranberry, juice 4.000000 1.100 1.000 

95001321 O Cranberry, juice-babyfood 4.000000 1.100 1.000 

95001880 O Hop 5.000000 1.000 1.000 

95002750 O Peppermint 3.000000 1.000 1.000 

95002760 O Peppermint, oil 3.000000 1.000 1.000 

95003520 O Spearmint 3.000000 1.000 1.000 

95003530 O Spearmint, oil 3.000000 1.000 1.000 

95003590 O Strawberry 4.000000 1.000 1.000 

95003591 O Strawberry-babyfood 4.000000 1.000 1.000 

95003600 O Strawberry, juice 4.000000 1.000 1.000 

95003601 O Strawberry, juice-babyfood 4.000000 1.000 1.000
Clopyralid Dietary Exposure and Risk Assessment

PC Code: 117401/117403 DP Number: D399390

Page 11 of 11

 

Attachment 2: Results of Chronic Dietary Exposure Analysis

Chronic PAD: 0.15 mg/kg bw/day 

Residue file name: C:\Documents and Settings\ddotson\My Documents\Deemfcid\Clopyralid\

ClopyralidChronic2.R98

Residue file dated: 03-02-2012/16:56:18/8 Analysis Date 03-02-2012/16:57:23

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ---------------

U.S. Population (total) 0.013895 9.3%

U.S. Population (spring season) 0.014217 9.5%

U.S. Population (summer season) 0.013855 9.2%

U.S. Population (autumn season) 0.013748 9.2%

U.S. Population (winter season) 0.013769 9.2%

Northeast region 0.014195 9.5%

Midwest region 0.014629 9.8%

Southern region 0.013132 8.8%

Western region 0.014052 9.4%

Hispanics 0.014065 9.4%

Non-hispanic whites 0.013701 9.1%

Non-hispanic blacks 0.014851 9.9%

Non-hisp/non-white/non-black 0.013954 9.3%

All infants (< 1 year) 0.013726 9.2%

Nursing infants 0.005766 3.8%

Non-nursing infants 0.016748 11.2%

Children 1-6 yrs 0.034090 22.7%

Children 7-12 yrs 0.021466 14.3%

Females 13-19 (not preg or nursing) 0.011665 7.8%

Females 20+ (not preg or nursing) 0.009456 6.3%

Females 13-50 yrs 0.010835 7.2%

Females 13+ (preg/not nursing) 0.011582 7.7%

Females 13+ (nursing) 0.012518 8.3%

Males 13-19 yrs 0.015007 10.0%

Males 20+ yrs 0.011198 7.5%

Seniors 55+ 0.009329 6.2%

Children 1-2 yrs 0.037039 24.7%

Children 3-5 yrs 0.033869 22.6%

Children 6-12 yrs 0.022590 15.1%

Youth 13-19 yrs 0.013383 8.9%

Adults 20-49 yrs 0.010847 7.2%

Adults 50+ yrs 0.009407 6.3%

Females 13-49 yrs 0.010170 6.8%

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