Initial to indicate certification as to information on this page (full text of certification is on page one). Date INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary. 2. Case # and Name 3. Date and Type of DCI and Number

4. EPA Product Registration 5. I wish to cancel this product registration voluntarily 6. Generic Data 7. Product Specific Data 6a. I am claiming a Generic Data Exemption because I obtain the active ingredient from the source EPA registration number listed below. 6b. I agree to satisfy Generic Data Requirements as indicated on the attached form entitled "Requirements Status and Registrant's Response." 7a. My product is an MUP and I agree to satisfy the MUP requirement on the attached form entitled "Requirements Status and Registrant's Response." 7b. My product is an EUP and I agree to satisfy the EUP requirement on the attached form entitled "Requirements Status and Registrant's Response." OMB Approval 2070-0174 EPA FORM 6300-4

1. Company Name and Address NUFARM LIMITED 4020 AERIAL CENTER PKWY., STE 101 MORRISVILLE, NC 27560 N/A - Myclobutanil Chemical # and Name: 128857 Myclobutanil 14-Apr-2016 GENERIC ID # GDCI-128857-1536 

### United States Environmental Protection Agency

Washington, D.C. 20460 DATA CALL-IN RESPONSE 1 Page of 1

35935-99

8. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law. Signature and Title of Company's Authorized Representative ______________________________________________________ 10. Name of Company N/A N/A

9. Date

11. Phone NumberInitial to indicate certification as to information on this page (full text of certification is on page one). Date INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary. 2. Case # and Name 3. Date and Type of DCI and Number

4. EPA Product Registration 5. I wish to cancel this product registration voluntarily 6. Generic Data 7. Product Specific Data 6a. I am claiming a Generic Data Exemption because I obtain the active ingredient from the source EPA registration number listed below. 6b. I agree to satisfy Generic Data Requirements as indicated on the attached form entitled "Requirements Status and Registrant's Response." 7a. My product is an MUP and I agree to satisfy the MUP requirement on the attached form entitled "Requirements Status and Registrant's Response." 7b. My product is an EUP and I agree to satisfy the EUP requirement on the attached form entitled "Requirements Status and Registrant's Response." OMB Approval 2070-0174 EPA FORM 6300-4

1. Company Name and Address ALBAUGH, LLC P.O. Box 2127 VALDOSTA, GA 316042127 N/A - Myclobutanil Chemical # and Name: 128857 Myclobutanil 14-Apr-2016 GENERIC ID # GDCI-128857-1536 

### United States Environmental Protection Agency

Washington, D.C. 20460 DATA CALL-IN RESPONSE 1 Page of 1

42750-142

8. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law. Signature and Title of Company's Authorized Representative ______________________________________________________ 10. Name of Company N/A N/A

9. Date

11. Phone NumberInitial to indicate certification as to information on this page (full text of certification is on page one). Date INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary. 2. Case # and Name 3. Date and Type of DCI and Number

4. EPA Product Registration 5. I wish to cancel this product registration voluntarily 6. Generic Data 7. Product Specific Data 6a. I am claiming a Generic Data Exemption because I obtain the active ingredient from the source EPA registration number listed below. 6b. I agree to satisfy Generic Data Requirements as indicated on the attached form entitled "Requirements Status and Registrant's Response." 7a. My product is an MUP and I agree to satisfy the MUP requirement on the attached form entitled "Requirements Status and Registrant's Response." 7b. My product is an EUP and I agree to satisfy the EUP requirement on the attached form entitled "Requirements Status and Registrant's Response." OMB Approval 2070-0174 EPA FORM 6300-4

1. Company Name and Address DOW AGROSCIENCES LLC 9330 ZIONSVILLE RD 308/2E INDIANAPOLIS, IN 462681054 N/A - Myclobutanil Chemical # and Name: 128857 Myclobutanil 14-Apr-2016 GENERIC ID # GDCI-128857-1536 

### United States Environmental Protection Agency

Washington, D.C. 20460 DATA CALL-IN RESPONSE 1 Page of 1

62719-407

8. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law. Signature and Title of Company's Authorized Representative ______________________________________________________ 10. Name of Company N/A N/A

9. Date

11. Phone NumberInitial to indicate certification as to information on this page (full text of certification is on page one) 13. Phone Number 10. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law.
12. Name of Company 11. Date OMB Approval 2070-0174 EPA FORM 6300-3 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Signature and Title of Company's Authorized Representative _________________________________________________________________ NUFARM LIMITED 4020 AERIAL CENTER PKWY., STE 101 MORRISVILLE, NC 27560

Nontarget Plant Protection Data Requirements (Conventional Chemical)

Terrestrial and Aquatic Nontarget Organisms Data Requirements (Conventional Chemical) 850.4100 850.4150 850.4400

850.1075 850.2100 850.3040

850.4500 Seedling Emergence and Seedling Growth

Vegetative Vigor Aquatic Plant Toxicity Using Lemna spp

Fish acute toxicity test, freshwater and marine Avian acute oral toxicity test Field testing for pollinators
Algal Toxicity N/A - Myclobutanil Chemical # and Name: 128857 Myclobutanil 14-Apr-2016 GENERIC ID # GDCI-128857-1536

J,I,C,Q,B,A J,I,C,Q,B,A J,I,C,Q,B,A

J,I,C,Q,B,A J,I,C,Q,B,A J,I,C,Q,B,A

J,I,C,Q,B,A TEP TEP TEP

TGAI TGAI TEP

TEP 12 12 12

12 12 24

12 1of Page

(3, 6, 14)
(7) N N N

N N Y

N 2OMB Approval 2070-0174 EPA FORM 6300-3 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number NUFARM LIMITED 4020 AERIAL CENTER PKWY., STE 101 MORRISVILLE, NC 27560

850.4550 SS-1113 SS-1311 SS-1312 SS-1313 SS-1314 SS-1315 Cyanobacteria (Anabaena flos-aquae) Toxicity

Residue Analysis of Nectar and Pollen in Flowering Crops Honey bee adult acute oral toxicity Honey bee larvae acute oral toxicity Honey bee adult chronic oral toxicity Honey bee larvae chronic oral toxicity Semi-field testing for pollinators N/A - Myclobutanil Chemical # and Name: 128857 Myclobutanil 14-Apr-2016 GENERIC ID # GDCI-128857-1536

J,I,C,Q,B,A J,I,C,Q,B,A J,I,C,Q,B,A J,I,C,Q,B,A J,I,C,Q,B,A J,I,C,Q,B,A J,I,C,Q,B,A TEP TEP TGAI TGAI TGAI TGAI TEP 12 24 12 12 12 12 24 2of Page

(7) (1, 4, 14) (5) (10) (8) (9, 11, 14) (2, 12, 13, 14) N Y N N N Y Y 213. Phone Number 10. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law.
12. Name of Company 11. Date OMB Approval 2070-0174 EPA FORM 6300-3 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Signature and Title of Company's Authorized Representative _________________________________________________________________ ALBAUGH, LLC P.O. Box 2127 VALDOSTA, GA 316042127

Nontarget Plant Protection Data Requirements (Conventional Chemical)

Terrestrial and Aquatic Nontarget Organisms Data Requirements (Conventional Chemical) 850.4100 850.4150 850.4400

850.1075 850.2100 850.3040

850.4500 Seedling Emergence and Seedling Growth

Vegetative Vigor Aquatic Plant Toxicity Using Lemna spp

Fish acute toxicity test, freshwater and marine Avian acute oral toxicity test Field testing for pollinators
Algal Toxicity N/A - Myclobutanil Chemical # and Name: 128857 Myclobutanil 14-Apr-2016 GENERIC ID # GDCI-128857-1536

J,I,C,Q,B,A J,I,C,Q,B,A J,I,C,Q,B,A

J,I,C,Q,B,A J,I,C,Q,B,A J,I,C,Q,B,A

J,I,C,Q,B,A TEP TEP TEP

TGAI TGAI TEP

TEP 12 12 12

12 12 24

12 1of Page

(3, 6, 14)
(7) N N N

N N Y

N 2OMB Approval 2070-0174 EPA FORM 6300-3 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number ALBAUGH, LLC P.O. Box 2127 VALDOSTA, GA 316042127

850.4550 SS-1113 SS-1311 SS-1312 SS-1313 SS-1314 SS-1315 Cyanobacteria (Anabaena flos-aquae) Toxicity

Residue Analysis of Nectar and Pollen in Flowering Crops Honey bee adult acute oral toxicity Honey bee larvae acute oral toxicity Honey bee adult chronic oral toxicity Honey bee larvae chronic oral toxicity Semi-field testing for pollinators N/A - Myclobutanil Chemical # and Name: 128857 Myclobutanil 14-Apr-2016 GENERIC ID # GDCI-128857-1536

J,I,C,Q,B,A J,I,C,Q,B,A J,I,C,Q,B,A J,I,C,Q,B,A J,I,C,Q,B,A J,I,C,Q,B,A J,I,C,Q,B,A TEP TEP TGAI TGAI TGAI TGAI TEP 12 24 12 12 12 12 24 2of Page

(7) (1, 4, 14) (5) (10) (8) (9, 11, 14) (2, 12, 13, 14) N Y N N N Y Y 213. Phone Number 10. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law.
12. Name of Company 11. Date OMB Approval 2070-0174 EPA FORM 6300-3 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Signature and Title of Company's Authorized Representative _________________________________________________________________ DOW AGROSCIENCES LLC 9330 ZIONSVILLE RD 308/2E INDIANAPOLIS, IN 462681054

Nontarget Plant Protection Data Requirements (Conventional Chemical)

Terrestrial and Aquatic Nontarget Organisms Data Requirements (Conventional Chemical) 850.4100 850.4150 850.4400

850.1075 850.2100 850.3040

850.4500 Seedling Emergence and Seedling Growth

Vegetative Vigor Aquatic Plant Toxicity Using Lemna spp

Fish acute toxicity test, freshwater and marine Avian acute oral toxicity test Field testing for pollinators
Algal Toxicity N/A - Myclobutanil Chemical # and Name: 128857 Myclobutanil 14-Apr-2016 GENERIC ID # GDCI-128857-1536

J,I,C,Q,B,A J,I,C,Q,B,A J,I,C,Q,B,A

J,I,C,Q,B,A J,I,C,Q,B,A J,I,C,Q,B,A

J,I,C,Q,B,A TEP TEP TEP

TGAI TGAI TEP

TEP 12 12 12

12 12 24

12 1of Page

(3, 6, 14)
(7) N N N

N N Y

N 2Date OMB Approval 2070-0174 EPA FORM 6300-3 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number DOW AGROSCIENCES LLC 9330 ZIONSVILLE RD 308/2E INDIANAPOLIS, IN 462681054

850.4550 SS-1113 SS-1311 SS-1312 SS-1313 SS-1314 SS-1315 Cyanobacteria (Anabaena flos-aquae) Toxicity

Residue Analysis of Nectar and Pollen in Flowering Crops Honey bee adult acute oral toxicity Honey bee larvae acute oral toxicity Honey bee adult chronic oral toxicity Honey bee larvae chronic oral toxicity Semi-field testing for pollinators N/A - Myclobutanil Chemical # and Name: 128857 Myclobutanil 14-Apr-2016 GENERIC ID # GDCI-128857-1536

J,I,C,Q,B,A J,I,C,Q,B,A J,I,C,Q,B,A J,I,C,Q,B,A J,I,C,Q,B,A J,I,C,Q,B,A J,I,C,Q,B,A TEP TEP TGAI TGAI TGAI TGAI TEP 12 24 12 12 12 12 24 2of Page

(7) (1, 4, 14) (5) (10) (8) (9, 11, 14) (2, 12, 13, 14) N Y N N N Y Y 2

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS N/A - Myclobutanil GDCI-128857-1536

1 2 3 4

5 6

7

8 Key:Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

The need for measures of residues in pollen/nectar will be determined based upon lower tiered tests and/or other lines of evidence, and the need for a refined pollinator risk assessment. The need for a semi-field test for pollinators (i.e., either a field-feeding test or a tunnel test) will be determined based upon the results of lower-tiered tests and/or other lines of evidence, and the need for a refined pollinator risk assessment. The need for a field test for pollinators will be determined based upon lower-tiered tests and/or other lines of data and the need for a refined pollinator risk assessment. The following elements should be considered when developing study protocol(s) for the monitoring of residues in pollen/nectar. (1) Consideration of the range of application methods and environmental conditions (e.g., soil and hydric regimes) that the target crop(s) may be under. (2) Consideration of the attractiveness of the selected crop to pollinators (3) Consideration of a collection schedule sufficient to allow for an understanding of the character of residues, in the pollen/nectar and/or plant tissues, over time. (4) Consideration of data sufficient to determine whether residues of the active ingredient and/or degradation product(s) accumulates in soil and is/are bioavailable for plant to uptake in a following planting, and therefore result in potential exposure to pollinators. (5) Consideration of the market proportion of the selected target crop(s).See the OECD 213: OECD Guidelines for the Testing of Chemicals. Honeybees, Acute Oral Toxicity Test. 213. http://www.oecd-ilibrary.org/environment/test-no-213-honeybees-acute-oraltoxicity-test_9789264070165-en See information and guidance identified in the EPA documents, (i) USEPA. 2012. White Paper in Support of the Proposed Risk Assessment Process for Bees. Submitted to the FIFRA Scientific Advisory Panel for Review and Comment September 11 - 14, 2012. Office of Chemical Safety and Pollution Prevention, Office of Pesticide Programs Environmental Fate and Effects Division, Environmentally Protection Agency, Washington, DC; Environmental Assessment Directorate, Pest Management Regulatory Agency, California Department of Pesticide Regulation. June 19, 2014. http://www2.epa.gov/sites/production/files/2014-06/documents/pollinator_risk_assessment_guidance_06_19_14.pdf and USEPA. 2012c. "Field Testing for Pollinators." Ecological Effects Test Guidance OCSPP 850.3030. EPA 712-C-017. Web. http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPPT-2009-0154-0018. Results for studies conducted for (i) the freshwater green alga, Selenastrum capricornutum, (ii) the freshwater diatom, Navicula pelliculosa, (iii) the marine diatom, Skeletonema costatum, and (iv) the cyanobacteria species Anabaena flos-aquae, must be submitted to satisfy this requirement. Final 850 guidelines for the algal testing were posted in June 2012. The Public Draft OPPTS 850.5400 Algal Toxicity guideline was split into two separate guidelines and renumbered with the cyanobacteria species separated into OCSPP 850.4550 and the other three species under OCSPP 850.4500. OECD has not yet finalized test guidelines for chronic studies, and efforts are underway to develop standardized guidelines for assessing the effects from chronic exposure to adult and larvae in the laboratory. Discussion of the study design elements for the 10-day adult toxicity test can be found in Appendix O of the European Food Safety Authority (EFSA) guidance document: EFSA. Guidance on the risk assessment of plant protection products on bees (Apis mellifera, Bombus spp. and solitary bees. EFSA Jounral 2013; 11(7):3295, 266 pp. doi: Case # and Name: DCI Number: 1 Page: of

Footnotes:The following footnotes are referenced in column two (5. Study Title) of the Requirements Status and Registrant's Response form. These footnotes apply in addition to any test notes included in 40 CFR Part 158 with respect to the particular data requirement. Use Categories Key: A - Terrestrial food crop B - Terrestrial feed crop C - Terrestrial nonfood crop I - Greenhouse nonfood crop J - Forestry use Q - Residential outdoor use 2

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS N/A - Myclobutanil GDCI-128857-1536

9 10 11 12

13 14 Key:Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

10.2903/j.efsa.2013.3295. OECD has not yet finalized test guidelines for chronic studies with honey bee larvae. OECD draft guidance is being developed, see OECD Draft Guidance Document Honey Bee (Apis mellifera) Larval Toxicity Test, Repeated Exposure, http://www.oecd.org/env/ehs/testing/Draft_GD_honeybees_rep_exp_for_2nd_CR_25_November_2013.pdf OECD Test Guideline 237 may be used to develop a protocol for this study (OECD. 2013 Guidelines for Testing Chemicals. Honey bee (Apis mellifera) larval toxicity test, single exposure.) See: http://www.oecd-ilibrary.org/environment/test-no-237-honey-bee-apis-mellifera-larval-toxicity-test-single-exposure_9789264203723-en. In some cases, information pertaining to acute toxicity to honey bee larvae may be obtained with the chronic honey bee larvae test thereby negating the need for separate acute and chronic larval toxicity tests. Formal guidelines for semi-field tests do not yet exist; however, information that can help guide the development of either a semi-field tunnel test protocol can be found at OECD 75, see: OECD. 2007. Series on Testing and Assessment Number 75. Guidance document on the honey bee (Apis mellifera L.) brood test under semi-field conditions. Environmental Directorate Joint Meeting of the Chemicals Committee and the Working Party on Chemicals, Pesticides and Biotechnology. ENV/JM/MONO(2007)22. August 31, 2007. http://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=env/jm/mono(2007)22&doclanguage=en. For field-feeding studies see the following: Oomen et al. 1992: Oomen, P. A. A. DeRuijter and J. Van der Steen. 1992. Method for honey bee brood feeding tests with insect growth-regulating insecticides. Bul OEPP/EPPO Bulletin 22: 613-616. A study protocol must be submitted to, and reviewed by EPA, prior to study initiation. Case # and Name: DCI Number: 2 Page: of 2

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS N/A - Myclobutanil GDCI-128857-1536

1 2 3 4

5 6

7

8 Key:Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

The need for measures of residues in pollen/nectar will be determined based upon lower tiered tests and/or other lines of evidence, and the need for a refined pollinator risk assessment. The need for a semi-field test for pollinators (i.e., either a field-feeding test or a tunnel test) will be determined based upon the results of lower-tiered tests and/or other lines of evidence, and the need for a refined pollinator risk assessment. The need for a field test for pollinators will be determined based upon lower-tiered tests and/or other lines of data and the need for a refined pollinator risk assessment. The following elements should be considered when developing study protocol(s) for the monitoring of residues in pollen/nectar. (1) Consideration of the range of application methods and environmental conditions (e.g., soil and hydric regimes) that the target crop(s) may be under. (2) Consideration of the attractiveness of the selected crop to pollinators (3) Consideration of a collection schedule sufficient to allow for an understanding of the character of residues, in the pollen/nectar and/or plant tissues, over time. (4) Consideration of data sufficient to determine whether residues of the active ingredient and/or degradation product(s) accumulates in soil and is/are bioavailable for plant to uptake in a following planting, and therefore result in potential exposure to pollinators. (5) Consideration of the market proportion of the selected target crop(s).See the OECD 213: OECD Guidelines for the Testing of Chemicals. Honeybees, Acute Oral Toxicity Test. 213. http://www.oecd-ilibrary.org/environment/test-no-213-honeybees-acute-oraltoxicity-test_9789264070165-en See information and guidance identified in the EPA documents, (i) USEPA. 2012. White Paper in Support of the Proposed Risk Assessment Process for Bees. Submitted to the FIFRA Scientific Advisory Panel for Review and Comment September 11 - 14, 2012. Office of Chemical Safety and Pollution Prevention, Office of Pesticide Programs Environmental Fate and Effects Division, Environmentally Protection Agency, Washington, DC; Environmental Assessment Directorate, Pest Management Regulatory Agency, California Department of Pesticide Regulation. June 19, 2014. http://www2.epa.gov/sites/production/files/2014-06/documents/pollinator_risk_assessment_guidance_06_19_14.pdf and USEPA. 2012c. "Field Testing for Pollinators." Ecological Effects Test Guidance OCSPP 850.3030. EPA 712-C-017. Web. http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPPT-2009-0154-0018. Results for studies conducted for (i) the freshwater green alga, Selenastrum capricornutum, (ii) the freshwater diatom, Navicula pelliculosa, (iii) the marine diatom, Skeletonema costatum, and (iv) the cyanobacteria species Anabaena flos-aquae, must be submitted to satisfy this requirement. Final 850 guidelines for the algal testing were posted in June 2012. The Public Draft OPPTS 850.5400 Algal Toxicity guideline was split into two separate guidelines and renumbered with the cyanobacteria species separated into OCSPP 850.4550 and the other three species under OCSPP 850.4500. OECD has not yet finalized test guidelines for chronic studies, and efforts are underway to develop standardized guidelines for assessing the effects from chronic exposure to adult and larvae in the laboratory. Discussion of the study design elements for the 10-day adult toxicity test can be found in Appendix O of the European Food Safety Authority (EFSA) guidance document: EFSA. Guidance on the risk assessment of plant protection products on bees (Apis mellifera, Bombus spp. and solitary bees. EFSA Jounral 2013; 11(7):3295, 266 pp. doi: Case # and Name: DCI Number: 1 Page: of

Footnotes:The following footnotes are referenced in column two (5. Study Title) of the Requirements Status and Registrant's Response form. These footnotes apply in addition to any test notes included in 40 CFR Part 158 with respect to the particular data requirement. Use Categories Key: A - Terrestrial food crop B - Terrestrial feed crop C - Terrestrial nonfood crop I - Greenhouse nonfood crop J - Forestry use Q - Residential outdoor use 2

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS N/A - Myclobutanil GDCI-128857-1536

9 10 11 12

13 14 Key:Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

10.2903/j.efsa.2013.3295. OECD has not yet finalized test guidelines for chronic studies with honey bee larvae. OECD draft guidance is being developed, see OECD Draft Guidance Document Honey Bee (Apis mellifera) Larval Toxicity Test, Repeated Exposure, http://www.oecd.org/env/ehs/testing/Draft_GD_honeybees_rep_exp_for_2nd_CR_25_November_2013.pdf OECD Test Guideline 237 may be used to develop a protocol for this study (OECD. 2013 Guidelines for Testing Chemicals. Honey bee (Apis mellifera) larval toxicity test, single exposure.) See: http://www.oecd-ilibrary.org/environment/test-no-237-honey-bee-apis-mellifera-larval-toxicity-test-single-exposure_9789264203723-en. In some cases, information pertaining to acute toxicity to honey bee larvae may be obtained with the chronic honey bee larvae test thereby negating the need for separate acute and chronic larval toxicity tests. Formal guidelines for semi-field tests do not yet exist; however, information that can help guide the development of either a semi-field tunnel test protocol can be found at OECD 75, see: OECD. 2007. Series on Testing and Assessment Number 75. Guidance document on the honey bee (Apis mellifera L.) brood test under semi-field conditions. Environmental Directorate Joint Meeting of the Chemicals Committee and the Working Party on Chemicals, Pesticides and Biotechnology. ENV/JM/MONO(2007)22. August 31, 2007. http://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=env/jm/mono(2007)22&doclanguage=en. For field-feeding studies see the following: Oomen et al. 1992: Oomen, P. A. A. DeRuijter and J. Van der Steen. 1992. Method for honey bee brood feeding tests with insect growth-regulating insecticides. Bul OEPP/EPPO Bulletin 22: 613-616. A study protocol must be submitted to, and reviewed by EPA, prior to study initiation. Case # and Name: DCI Number: 2 Page: of 2

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS N/A - Myclobutanil GDCI-128857-1536

1 2 3 4

5 6

7

8 Key:Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

The need for measures of residues in pollen/nectar will be determined based upon lower tiered tests and/or other lines of evidence, and the need for a refined pollinator risk assessment. The need for a semi-field test for pollinators (i.e., either a field-feeding test or a tunnel test) will be determined based upon the results of lower-tiered tests and/or other lines of evidence, and the need for a refined pollinator risk assessment. The need for a field test for pollinators will be determined based upon lower-tiered tests and/or other lines of data and the need for a refined pollinator risk assessment. The following elements should be considered when developing study protocol(s) for the monitoring of residues in pollen/nectar. (1) Consideration of the range of application methods and environmental conditions (e.g., soil and hydric regimes) that the target crop(s) may be under. (2) Consideration of the attractiveness of the selected crop to pollinators (3) Consideration of a collection schedule sufficient to allow for an understanding of the character of residues, in the pollen/nectar and/or plant tissues, over time. (4) Consideration of data sufficient to determine whether residues of the active ingredient and/or degradation product(s) accumulates in soil and is/are bioavailable for plant to uptake in a following planting, and therefore result in potential exposure to pollinators. (5) Consideration of the market proportion of the selected target crop(s).See the OECD 213: OECD Guidelines for the Testing of Chemicals. Honeybees, Acute Oral Toxicity Test. 213. http://www.oecd-ilibrary.org/environment/test-no-213-honeybees-acute-oraltoxicity-test_9789264070165-en See information and guidance identified in the EPA documents, (i) USEPA. 2012. White Paper in Support of the Proposed Risk Assessment Process for Bees. Submitted to the FIFRA Scientific Advisory Panel for Review and Comment September 11 - 14, 2012. Office of Chemical Safety and Pollution Prevention, Office of Pesticide Programs Environmental Fate and Effects Division, Environmentally Protection Agency, Washington, DC; Environmental Assessment Directorate, Pest Management Regulatory Agency, California Department of Pesticide Regulation. June 19, 2014. http://www2.epa.gov/sites/production/files/2014-06/documents/pollinator_risk_assessment_guidance_06_19_14.pdf and USEPA. 2012c. "Field Testing for Pollinators." Ecological Effects Test Guidance OCSPP 850.3030. EPA 712-C-017. Web. http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPPT-2009-0154-0018. Results for studies conducted for (i) the freshwater green alga, Selenastrum capricornutum, (ii) the freshwater diatom, Navicula pelliculosa, (iii) the marine diatom, Skeletonema costatum, and (iv) the cyanobacteria species Anabaena flos-aquae, must be submitted to satisfy this requirement. Final 850 guidelines for the algal testing were posted in June 2012. The Public Draft OPPTS 850.5400 Algal Toxicity guideline was split into two separate guidelines and renumbered with the cyanobacteria species separated into OCSPP 850.4550 and the other three species under OCSPP 850.4500. OECD has not yet finalized test guidelines for chronic studies, and efforts are underway to develop standardized guidelines for assessing the effects from chronic exposure to adult and larvae in the laboratory. Discussion of the study design elements for the 10-day adult toxicity test can be found in Appendix O of the European Food Safety Authority (EFSA) guidance document: EFSA. Guidance on the risk assessment of plant protection products on bees (Apis mellifera, Bombus spp. and solitary bees. EFSA Jounral 2013; 11(7):3295, 266 pp. doi: Case # and Name: DCI Number: 1 Page: of

Footnotes:The following footnotes are referenced in column two (5. Study Title) of the Requirements Status and Registrant's Response form. These footnotes apply in addition to any test notes included in 40 CFR Part 158 with respect to the particular data requirement. Use Categories Key: A - Terrestrial food crop B - Terrestrial feed crop C - Terrestrial nonfood crop I - Greenhouse nonfood crop J - Forestry use Q - Residential outdoor use 2

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS N/A - Myclobutanil GDCI-128857-1536

9 10 11 12

13 14 Key:Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

10.2903/j.efsa.2013.3295. OECD has not yet finalized test guidelines for chronic studies with honey bee larvae. OECD draft guidance is being developed, see OECD Draft Guidance Document Honey Bee (Apis mellifera) Larval Toxicity Test, Repeated Exposure, http://www.oecd.org/env/ehs/testing/Draft_GD_honeybees_rep_exp_for_2nd_CR_25_November_2013.pdf OECD Test Guideline 237 may be used to develop a protocol for this study (OECD. 2013 Guidelines for Testing Chemicals. Honey bee (Apis mellifera) larval toxicity test, single exposure.) See: http://www.oecd-ilibrary.org/environment/test-no-237-honey-bee-apis-mellifera-larval-toxicity-test-single-exposure_9789264203723-en. In some cases, information pertaining to acute toxicity to honey bee larvae may be obtained with the chronic honey bee larvae test thereby negating the need for separate acute and chronic larval toxicity tests. Formal guidelines for semi-field tests do not yet exist; however, information that can help guide the development of either a semi-field tunnel test protocol can be found at OECD 75, see: OECD. 2007. Series on Testing and Assessment Number 75. Guidance document on the honey bee (Apis mellifera L.) brood test under semi-field conditions. Environmental Directorate Joint Meeting of the Chemicals Committee and the Working Party on Chemicals, Pesticides and Biotechnology. ENV/JM/MONO(2007)22. August 31, 2007. http://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=env/jm/mono(2007)22&doclanguage=en. For field-feeding studies see the following: Oomen et al. 1992: Oomen, P. A. A. DeRuijter and J. Van der Steen. 1992. Method for honey bee brood feeding tests with insect growth-regulating insecticides. Bul OEPP/EPPO Bulletin 22: 613-616. A study protocol must be submitted to, and reviewed by EPA, prior to study initiation. Case # and Name: DCI Number: 2 Page: of 2

### United States Environmental Protection Agency Washington, D.C. 20460 LIST OF ALL REGISTRANTS SENT THIS DATA CALL-IN NOTICE N/A - Myclobutanil Case # and Name: 1 Page: of 1

62719 35935 42750 DOW AGROSCIENCES LLC

NUFARM LIMITED ALBAUGH, LLC Co. Nr. Company Name Agent For Company

NUFARM LIMITED 9330 ZIONSVILLE RD 308/2E 4020 AERIAL CENTER PKWY., STE 101 P.O. Box 2127 Address City ZIP INDIANAPOLIS MORRISVILLE VALDOSTA 462681054 27560 316042127 OMB Approval 2070-0174

State IN NC GA DCI Number:GDCI-128857-1536

### United States Environmental Protection Agency Washington, D.C. 20460 LIST OF ALL REGISTRANTS SENT THIS DATA CALL-IN NOTICE N/A - Myclobutanil Case # and Name: 1 Page: of 1

62719 35935 42750 DOW AGROSCIENCES LLC

NUFARM LIMITED ALBAUGH, LLC Co. Nr. Company Name Agent For Company

NUFARM LIMITED 9330 ZIONSVILLE RD 308/2E 4020 AERIAL CENTER PKWY., STE 101 P.O. Box 2127 Address City ZIP INDIANAPOLIS MORRISVILLE VALDOSTA 462681054 27560 316042127 OMB Approval 2070-0174

State IN NC GA DCI Number:GDCI-128857-1536

### United States Environmental Protection Agency Washington, D.C. 20460 LIST OF ALL REGISTRANTS SENT THIS DATA CALL-IN NOTICE N/A - Myclobutanil Case # and Name: 1 Page: of 1

62719 35935 42750 DOW AGROSCIENCES LLC

NUFARM LIMITED ALBAUGH, LLC Co. Nr. Company Name Agent For Company

NUFARM LIMITED 9330 ZIONSVILLE RD 308/2E 4020 AERIAL CENTER PKWY., STE 101 P.O. Box 2127 Address City ZIP INDIANAPOLIS MORRISVILLE VALDOSTA 462681054 27560 316042127 OMB Approval 2070-0174

State IN NC GA DCI Number:GDCI-128857-1536