**Exhibit 10.1**

**SUMMARY OFEXECUTIVE OFFICER COMPENSATION FOR 2006**

*Executive OfficerCompensation for 2006—Base Salary and Target Bonus*

On March 16,2006, the Compensation Committee of the Board of Directors of Sepracor Inc.(the “Company”) approved the annual salaries to be paid to the Company’sexecutive officers during 2006. The Compensation Committee of the Company’sBoard of Directors may also grant a discretionary bonus to each of theCompany’s executive officers for work performed by such officer during the yearended December 31, 2006. Each officer’s bonus for 2006 shall be determinedbased on, among other things, the Company’s overall performance, as well assuch officer’s individual performance, during the fiscal year ended December 31,2006. Each executive officer has a target bonus for 2006 that is based on apercentage of such executive officer’s 2006 annual base salary. The table belowsets forth the annual base salaries, target bonus percentages and targetbonuses for 2006 for each of the Company’s executive officers:

| **Executive Officer**                                                          | ** ** | ** ** | ** ** | **Annual Salary** | ** ** | **2006 Target Bonus   Percentage** | ** ** | **2006 Target Bonus** | ** ** |
|-------------------------------------------------------------------------------------|------------|------------|------------|------------------------|------------|---------------------------------------------------|------------|---------------------------------|------------|
| Timothy J. Barberich  Chief Executive Officer                                       |       |       | $          | 875,000                |       |                                              |       | 80                              | %          |   |   | $ | 700,000 |   |   |
| William J. O’Shea  President and Chief Operating Officer                       |       |       | $          | 525,000                |       |                                              |       | 60                              | %          |   |   | $ | 315,000 |   |   |
| Mark H.N. Corrigan, M.D.  Executive Vice President, Research and Development        |       |       | $          | 450,000                |       |                                              |       | 50                              | %          |   |   | $ | 225,000 |   |   |
| David P. Southwell  Executive Vice President, Chief Financial Officer and Secretary |       |       | $          | 440,000                |       |                                              |       | 45                              | %          |   |   | $ | 198,000 |   |   |
| Robert F. Scumaci  Executive Vice President, Finance and Administration, Treasurer  |       |       | $          | 430,000                |       |                                              |       | 45                              | %          |   |   | $ | 193,500 |   |   |
| Douglas E.  Reedich, Ph.D., J.D.  Senior Vice President, Legal Affairs         |       |       | $          | 380,000                |       |                                              |       | 40                              | %          |   |   | $ | 152,000 |   |   |

 

*Executive OfficerCompensation for 2006—Stock-Based Awards*

Each executive officermay also be granted, from time to time, stock options, restricted stock orother awards pursuant to the Company’s stock incentive plans. The stock optionsgranted to executive officers typically vest either (1) upon theachievement of specified corporate objectives or (2) in five equal annualinstallments commencing one year from the date of grant.

*Other Compensation*

The Company has also (1) enteredinto letter agreements with certain of its executive officers, (2) enteredinto retention agreements with each of its executive officers and (3) agreedto make gross up payments to each of its executive officers in the event thatany payments received by them in connection with a change of control constituteparachute payments under Section 280G of the Internal Revenue Code of1986, as amended. The Company has previously filed these letter agreements,retention agreements and a summary of the 280G gross up plan with theSecurities and Exchange Commission.

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*Bonuses Paid toExecutive Officers for Service During Fiscal Year 2005*

Inaddition to the foregoing adjustments to executive compensation, theCompensation Committee of the Company’s Board of Directors approved cash bonuspayments for the Company’s executive officers in consideration of their serviceto the Company during the fiscal year ended December 31, 2005. The Companymade the bonus payments pursuant to its previously announced executive officerbonus program for the fiscal year ended December 31, 2005. The paymentswere based on, among other things, the Company’s overall performance, as wellas such officer’s individual performance during 2005. The table below setsforth such bonus payments.

| **Executive Officer**                                                          | ** ** | ** ** | ** ** | **Cash Bonus for   2005 Performance** | ** ** |
|-------------------------------------------------------------------------------------|------------|------------|------------|-----------------------------------------------------------|------------|
| Timothy J. Barberich  Chief Executive Officer                                       |       |       | $          | 330,000                                                   |       |   |
| William J. O’Shea  President and Chief Operating Officer                       |       |       | $          | 382,500                                                   |       |   |
| Mark H.N. Corrigan, M.D.  Executive Vice President, Research and Development        |       |       | $          | 184,500                                                   |       |   |
| David P. Southwell  Executive Vice President, Chief Financial Officer and Secretary |       |       | $          | 147,000                                                   |       |   |
| Robert F. Scumaci  Executive Vice President, Finance and Administration, Treasurer  |       |       | $          | 169,000                                                   |       |   |
| Douglas E.  Reedich, Ph.D., J.D.  Senior Vice President, Legal Affairs              |       |       | $          | 142,600                                                   |       |   |

 

 

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