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                                                                   EXHIBIT 10.21


                                GENOMICA, INC.
                           STOCK OPTION GRANT NOTICE
                           (1996 Stock Option Plan)

                                [Standard ISO]

Genomica Corporation (the "Company"), pursuant to its Amended and Restated 1996
Stock Option Plan (the "Plan"), hereby grants to Optionee an option to purchase
the number of shares of the Company's common stock set forth below. This option
is subject to all of the terms and conditions as set forth herein and in
Attachments I, II, and III, which are incorporated herein in their entirety.

Optionee:                               ____________________________

Date of Grant:                          ____________________________

Vesting Commencement Date:              ____________________________

Shares Subject to Option:               ____________________________

Exercise Price Per Share:               ____________________________

Expiration Date:                        ____________________________

                              ____ Incentive Stock Option (as defined by (S) 422
                                   of the Code)

                              ____ Nonstatutory Stock Option

Vesting Schedule:             [25%] vested on the one year anniversary of the
                              Vesting Commencement Date; 1/48 vests on each
                              monthly anniversary thereafter.

Payment: By cash or check.

Additional Terms/Acknowledgements: The undersigned Optionee acknowledges receipt
of, and understands and agrees to, this Grant Notice, the Stock Option Agreement
and the Plan. Optionee further acknowledges that as of the Date of Grant, this
Grant Notice, the Stock Option Agreement and the Plan set forth the entire
understanding between Optionee and the Company regarding the acquisition of
stock in the Company and supersede all prior oral and written agreements on that
subject with the exception of (i) options previously granted and delivered to
Optionee under the Plan, and (ii) the following agreements only:

     Other Agreements:          _______________________________________
                                _______________________________________
                                _______________________________________
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GENOMICA CORPORATION                              OPTIONEE:


By:___________________________________            ______________________________
                                                  Signature

Title:________________________________

Date:_________________________________            Date:_________________________

Attachment I:   Stock Option Agreement
Attachment II:  1996 Stock Option Plan
Attachment III: Notice of Exercise

                                      2.
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                             GENOMICA CORPORATION

                            STOCK OPTION AGREEMENT

     Pursuant to the Grant Notice and this Stock Option Agreement, the Company
has granted you an option to purchase the number of shares of the Company's
common stock ("Common Stock") indicated in the Grant Notice at the exercise
price indicated in the Grant Notice.

     Your option is granted in connection with and in furtherance of the
Company's compensatory benefit plan for the Company's employees (including
officers), directors or consultants, and is intended to comply with the
provisions of Rule 701 promulgated by the Securities and Exchange Commission
under the Securities Act of 1933, as amended (the "Securities Act").  Defined
terms not explicitly defined in this Stock Option Agreement but defined in the
Amended and Restated 1996 Stock Option Plan (the "Plan") shall have the same
definitions as in the Plan.

     The details of your option are as follows:

     1.   Vesting. Subject to the limitations contained herein, your option will
vest as provided in the Grant Notice, provided that vesting will cease upon the
termination of your Continuous Service.

     2.   Method Of Payment. Payment of the exercise price by cash or check is
due in full upon exercise of all or any part of your option.

     3.   Whole Shares.  Your option may only be exercised for whole shares.

     4.   Securities Law Compliance. In order for the option granted under this
agreement to be exercised, there must be an exemption from the Federal
Securities laws for the issuance of stock. In the event no such exemption is
available, you may be prohibited from exercising your option.

     5.   Term. The term of your option commences on the date of grant and
expires upon the earliest of:

               (i)   the Expiration Date indicated in the Grant Notice;

               (ii)  the day before the tenth (10th) anniversary of the Date of
Grant;

               (iii) twelve (12) months after your death, if you die during, or
within three (3) months after the termination of your Continuous Service; or

               (iv)  twelve (12) months after the termination of your Continuous
Service due to disability; or

               (v)   three (3) months after the termination of your Continuous
Service for any other reason, provided that if: (a) during any part of such
three (3) month period the option is not exercisable solely because of the
condition set forth in paragraph 4 (Securities Law

                                      1.
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Compliance), in which event the option shall not expire until the earlier of the
Expiration Date or until it shall have been exercisable for an aggregate period
of three (3) months after the termination of Continuous Service, and (b)
exercise of the option within three (3) months after termination of your
Continuous Service would result in liability under section 16(b) of the
Securities Exchange Act of 1934 (the "Exchange Act"), the option will expire on
the earliest of (i) the Expiration Date, (ii) the tenth (10th) day after the
last date upon which exercise would result in such liability or (iii) six (6)
months and ten (10) days after the termination of your Continuous Service.

          The Company has provided for continued vesting or extended
exercisability of your option under certain circumstances for your benefit, but
cannot guarantee that your option will necessarily be treated as an "incentive
stock option".

     6.   Exercise.

          (a)  You may exercise the vested portion of your option during its
term (and the unvested portion of your option if the Grant Notice so permits) by
delivering a notice of exercise (in a form designated by the Company) together
with the exercise price to the Secretary of the Company, or to such other person
as the Company may designate, during regular business hours, together with such
additional documents as the Company may then require.

          (b)  By exercising your option you agree that:

               (i)   as a condition to any exercise of your option, the Company
may require you to enter into an arrangement providing for the payment by you to
the Company of any tax withholding obligation of the Company arising by reason
of (1) the exercise of your option; (2) the lapse of any substantial risk of
forfeiture as required by Section 83 of the Internal Revenue Code; or (3) the
disposition of shares acquired upon such exercise;

               (ii)  you will notify the Company in writing within fifteen (15)
days after the date of any disposition of any of the shares of the Common Stock
issued upon exercise of an incentive stock option that occurs within two (2)
years after the date of your option grant or within one (1) year after such
shares of Common Stock are transferred upon exercise of your option; and

               (iii) you will execute and deliver such other agreements as may
be reasonably requested by the Company and/or the underwriter(s) which are
consistent with the provisions of Section 9 below or which are necessary to give
further effect thereto.

     7.   Proprietary Information and Invention Agreement. You acknowledge that
by agreeing to enter into this Stock Option Agreement, you also agree to be
bound by the Company's Proprietary Information and Invention Agreement.

     8.   Transferability. Your option is not transferable, except by will or by
the laws of descent and distribution. Furthermore, during your lifetime, your
option may only be exercised by you. Upon your death, the person to whom your
rights have passed by will or by

                                      2.
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the laws of descent and distribution may exercise your option, so long as they
comply with the Plan.

     9.   Market Standstill. In connection with the first underwritten
registration of the offering of any securities of the Company under the
Securities Act, you agree not to sell or otherwise transfer or dispose of any
shares of Common Stock or other securities of the Company during such period
(not to exceed one hundred eighty (180) days) following the effective date of
the registration statement of the Company filed under the Securities Act as may
be requested by the Company or the representative of the underwriters, provided
that all executive officers and directors of the Company have similarly agreed.
Furthermore, the Company may impose stop-transfer instructions with respect to
securities subject to the foregoing restrictions until the end of such period.

     10.  Right of First Refusal. Before any shares of Common Stock (the
"Shares") issued upon exercise of an option to you or any transferee (either
being sometimes referred to herein as the "Holder") may be sold or otherwise
transferred (including transfer by gift or operation of law), the Company shall
have an assignable right of first refusal to purchase the Shares on the terms
and conditions set forth in this Section 10 (the "Right of First Refusal").

          (a) Notice of Proposed Transfer. The Holder of the Shares shall
deliver to the Company a written notice (the "Notice") stating: (i) the Holder's
bona fide intention to sell or otherwise transfer the Shares; (ii) the name of
each proposed purchaser or other transferee (the "Proposed Transferee"); (iii)
the number of Shares to be transferred to each Proposed Transferee; and (iv) the
bona fide cash price or other consideration for which the Holder proposed to
transfer the Shares (the "Offered Price"); and the Holder shall offer to sell
the Shares at the Offered Price to the Company.

          (b) Exercise of Right of First Refusal. At any time within thirty (30)
days after receipt of the Notice, the Company or its assignee may, by giving
written notice to the Holder, elect to purchase all (but not less than all) of
the Shares proposed to be transferred to any one or more of the Proposed
Transferees, at the Offered Price.

          (c) Payment. Payment of the purchase price shall be made, at the
option of the Company or its assignee, either (i) in cash (by check) or (ii) in
the manner and at the time(s) set forth in the Notice.

          (d) Holder's Right to Transfer. If all the Shares proposed in the
Notice to be transferred to a given Proposed Transferee are not purchased by the
Company and/or its assignee as provided in this Section 10, then the Holder may
sell or otherwise transfer such Shares to that Proposed Transferee at the
Offered Price or at a higher price, provided, that, such sale or other transfer
is consummated within one hundred twenty (120) days after the date of the Notice
and provided further that any such sale or other transfer is effected in
accordance with any applicable securities laws. If the Shares described in the
Notice are not transferred to the Proposed Transferee within such period, a new
Notice shall be given to the Company, and the Company shall again be offered the
Right of First Refusal, before any Shares held by the Holder may be sold or
otherwise transferred.

                                      3.
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          (e) Exception for Certain Family Transfers. Anything to the contrary
contained in this Section 10 notwithstanding, the transfer of any or all of the
Shares during the Optionee's lifetime or on the Optionee's death by will or
intestacy to Optionee's immediate family or to a trust for the benefit of
Optionee or Optionee's immediate family shall be exempt from the provisions of
this Section 10; provided that, as a condition to receiving the Shares, the
transferee or other recipient shall agree in writing to receive and hold the
Shares so transferred subject to the provisions of the Plan, and to transfer
such Shares no further except in accordance with the terms of the Plan. As used
herein, "immediate family" shall mean spouse, lineal descendant or antecedent,
father, mother, brother or sister.

          (f) Termination of Right of First Refusal. The Right of First Refusal
shall terminate as to any Shares upon the first sale of Common Stock of the
Company to the general public pursuant to a registration statement filed with
and declared effective by the Securities and Exchange Commission (other than a
registration statement solely covering an employee benefit plan or corporate
reorganization).

     11.  Option Not a Service Contract. Your option is not an employment
contract and nothing in your option shall be deemed to create in any way
whatsoever any obligation on your part to continue in the employ of the Company,
or of the Company to continue your employment with the Company. In addition,
nothing in your option shall obligate the Company, or any Affiliate of the
Company, or their respective stockholders, Board of Directors, officers or
employees to continue any relationship which you might have as a Director or
Consultant for the Company.

     12.  Notices. Any notices provided for in your option or the Plan shall be
given in writing and shall be deemed effectively given upon receipt or, in the
case of notices delivered by the Company to you, five (5) days after deposit in
the United States mail, postage prepaid, addressed to you at the last address
you provided to the Company.

     13.  Governing Plan Document. Your option is subject to all the provisions
of the Plan, the provisions of which are hereby made a part of your option,
including without limitation the provisions of the Plan relating to option
provisions, and is further subject to all interpretations, amendments, rules and
regulations which may from time to time be promulgated and adopted pursuant to
the Plan. In the event of any conflict between the provisions of your option and
those of the Plan, the provisions of the Plan shall control.

                                      4.