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Page 2 of 3 Termination of Tanol Derivatives (Furanones) Registration Review

In September 2011, the Agency initiated the registration review of the tanol derivatives (furanones) with the publication of a Preliminary Work Plan (PWP) and support documents which can be found at: http://www.regulations.gov/#!docketDetail;D =EPA

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. The registration review case was designated as case 3138. The two substances that were included in the tanol derivatives case were: gamma

- nonalactone (2(3H)

- furanone, dihydro

- 5

- pentyl) , and gamma

- undecalactone (5

- heptyldihydro

- 2 (3H )

- furanone). These two substances only occur in pesticide products which also contain d

- limonene. During the 60

- day comment period that followed the opening of the public docket, the Agency received no comments. The public comment period closed on Novem ber 29, 2011. Additional background information about the furanones may be found in the PWP and the docket.

Prior to and following initiation of the Furanones R egistration R eview, the Agency has been considering the role and status of the fur a nones in currently registered pesticide products. That led to a determination that the role of the tanol derivatives in currently registered pesticide products containing d

- limonene is not as an active ingredient. Instead, their presence in those currently re gistered pesticide products are as an inert ingredient

. Consequently, the Agency has redesignated the tanol derivatives

, at concentrations below 0 .1% in products containing d

- limonene

, from active ingredient statu s to that of inert in gredients . Additionally, all registrants of products containing these furanone s along with d

- limonene have changed the status of the furanone ingredient s from an active ingredient to an inert ingredient

. As a result, there are no longer any currently registered p esticide products that contain the furanone s as an active ingredient and therefore, no currently registered pesticide products remain in case 3138. Since there are no currently registered pesticide products in case 3138

, and no currently registered pestic ide products which contain the furanones as an active ingredient in combination with d

- limonene

, the Agency is hereby terminating the registration review of case 3138 pursuant to 40 CFR Section 155.42

. Additionally, in this announcement of the term ination of the Furanones Registration Review, the Agency is also announcing the redesignation of the tanol derivatives in concentrations of less than 0 .1% in products containing d

- limonene as inert ingredients

.

Redesig n ation of the Tanol Deriv at i v es ( Furanone s ) to Inert Ingredients

The tanol derivatives are naturally occurring lactones (cyclic esters) found in fruits (e.g., apricots, and peaches), meat and milk. They have been approved as a food additive by the US Food and Drug Administration (FDA)

, and are used in cosmetic products (such as lotions, detergents, and perfumes). Based on the concentration and the role of the tanol derivatives in currently registered products, the Agency has redesignated the tanol derivatives as inert ingredients. T he Agency has evaluated data on the tanol derivatives regarding their use as fragrance components in nonfood use pesticide product formulations ( as part of the Fragrance Pilot Program, http://www.epa.gov/opprd001/inerts/fmaingredient.pdf )

, and found that

, at concentrations below 0.1%, the tanol derivatives in combination with d

- limonene do not function as pesticidal active ingredients. Therefore, the Agency determined that the pre s ence of tanol derivatives in pesticide products containing d

- limonene is a fragrance component of such end useDocket Number: EPA

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Page 3 of 3 products. The Agency does not consider such use of tanol derivatives for fragrance purposes at concentrations below 0.1% to be pesticidal.

With the redesignation of the tanol derivatives, and the absence of any currently registered pesticides with tanol derivatives as an active ingredient, the Agency is concluding the

r egistration review of case 3138, tanol derivatives, as discussed her e in. Th is rede signation of the tanol derivatives from active ingredient s to inert ingredient s , when in combination with the active ingredient d

- limonene, does not change the status of any pesticide products which contain

one or more of the tanol derivatives in combinati on with d

- limonene as an active ingredient. The products which were originally part of the Furanones Registration Review contain d

- limonene as an active ingredient and are included in the d

- limonene Registration Review

, case 3083 . These products remain in the d

- limonene Registration Review case and are subject to that registration review.