Page 2 of 43 

 Terrestrial field dissipation studies (835.6100): No acceptable studies have been 

submitted. The TFD is a keystone study that allows for direct comparison of the 

conceptual model of pesticide behavior derived from laboratory data with real world 

applications in the field. Without these data, EFED has no way to confirm that the 

predicted behavior will happen. 

 Environmental Chemistry Methods for Soil (OCSPP Guideline 850.6100) for parent 

and major degradates. No acceptable studies have been submitted 

 Environmental Chemistry Methods for Water (OCSPP Guideline 850.6100) for parent 

and major degradates to support the aquatic field dissipation study. No acceptable studies 

have been submitted 

The following ecological effect data gaps exist for dimethomorph: 

 Rainbow Trout Early-Life Stage Toxicity Study (OCSPP Guideline 850.1400): 

Dimethomorph has outdoor uses that may result in exposure to fish. Significant reductions in 

the post-hatch weight and hatchling success of freshwater (MRID 44418104) and 

estuarine/marine fish (MRID 48326906), respectively, were observed at all test levels as low 

as 34 and 63 μg a.i./L, respectively, that a No Effect concentration (NOAEC) could not be 

produced to assess the risk to fish on a chronic basis. A NOAEC of 25 μg a.i./L at the level 

of the modeled 60-day EEC from the FL cabbage scenario (D316329) would result in a LOC 

exceedance. An ELS study with freshwater fish, specifically the rainbow trout, is requested 

to be repeated with lower concentrations to produce an NOAEC. Currently, an acute to 

chronic ratio (ACR) for estuarine/marine fish from the freshwater data is not appropriate 

because the acceptable acute and chronic studies used different freshwater species that 

prevented the calculations. Instead of asking for another ELS study using estuarine/marine 

fish with lower doses to produce an NOAEC to assess chronic risk to estuary fish, EFED is 

only asking that the rainbow trout ELS study be repeated with lower doses to produce an 

NOAEC in order to calculate an ACR using freshwater data on the same species (e.g., 

rainbow trout) to estimate the NOAEC for estuarine/marine fish. Without a repeated ELS 

study with the rainbow trout, chronic risk to both freshwater and estuarine/marine fish will be 

presumed.

 Avian Acute Oral with a Passerine Species (OCSPP Guideline 850.2100): Acceptable 

acute avian acute oral toxicity data were not submitted for a passerine species exposed to 

dimethomorph, which is now required under the 40 CFR Part 158 data requirements. 

However, in the most recent risk assessment that stated while the ‘RQ <0.15’ of a 20 gram 

bird that eat short grass exceeds the Agency’s acute listed species LOC of 0.1, this ‘RQ’ is 

expected to be lower than the LOC because none of the other RQs exceeded the LOC and a 

non-definitive endpoint (i.e., LD50 value >2,000 mg/kg-bw) based on the bobwhite quail 

was used to calculate that ‘RQ’ which resulted in exceeding the LOC where no mortality or 

other signs of toxicity were observed at the highest level tested. Though the available 

bobwhite quail study indicates dimethomorph has low toxicity to upland game bird species, it 

is uncertain whether passerines may be more or less sensitive to this chemical as a result of 

their higher metabolic rate and differing metabolic pathways. Given the predicted ‘RQ’ of 

<0.15 that exceeded the LOC for small-sized birds, EFED cannot preclude the potential risk 

to passerines which are small-sized birds. An avian oral toxicity study is needed for a 
Page 3 of 43 

passerine species. A passerine study protocol must be submitted for review by the Agency 

prior to initiation of the study.
Page 4 of 43 

 

Problem Formulation for the Environmental Fate and 

Ecological Risk, Endangered Species, and Drinking 

Water Assessments in Support of the Registration 

Review of Dimethomorph 

acryloyl]morpholine; 4-[3-(4-Chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-oxo-2-

propenyl]morpholine 

CAS Registry Number: 110488-70-5

PC Code: 268800 

Prepared by:

Stephen Carey, Biologist 

Ibrahim Abdel-Saheb, Ph.D., Environmental Scientist 

 U. S. Environmental Protection Agency

 Office of Pesticide Programs

 Environmental Fate and Effects Division

 Environmental Risk Branch VI

 1200 Pennsylvania Ave., NW

 Mail Code 7507P

 Washington, DC 20460

Reviewed by:

William P. Eckel, Senior Science Advisor 

Brian Kiernan, Biologist 

Mark Corbin, ERB6 Chief 

Decemeber 6, 2012 

Office of Chemical Safety 

and Pollution Prevention 
Page 5 of 43 

Contents

1. Introduction ............................................................................................................................. 6

2. Conclusions from Previous Risk Assessments ....................................................................... 7

2.1. Ecological Risk Assessments .......................................................................................... 7

2.2. Drinking Water Exposure Assessments ........................................................................... 7

2.3. Clean Water Act Programs ............................................................................................... 7

3. Environmental Fate and Transport ............................................................................................. 8

3.1. Transformation Products ................................................................................................ 10

4. Receptors............................................................................................................................... 10

4.1. Effects to Aquatic Organisms ........................................................................................ 10

4.2. Effects to Terrestrial Organisms .................................................................................... 11

4.3. Ecological Incidents ....................................................................................................... 12

5. Exposure Pathways of Concern ............................................................................................ 12

6. Analysis Plan ........................................................................................................................... 13

6.1. Stressors of Concern....................................................................................................... 13

6.2. Measures of Exposure ................................................................................................... 13

6.3. Measures of Effect ......................................................................................................... 13

6.4. Endangered Species Assessments .................................................................................. 14

6.5. Endocrine Disruptor Screening Program ....................................................................... 14

7. Environmental Fate and Ecological Effects Data ................................................................. 14

7.1. Environmental Fate ............................................................................................................ 14

7.2. Effects ................................................................................................................................ 17

8. References ................................................................................................................................ 21
Page 6 of 43 

1. Introduction 

EFED evaluated the most recent ecological risk assessments for Dimethomorph in association 

with the updated toxicity, exposure, and usage information to determine if sufficient data are 

available and if further updates are needed to support registration review. Recent risk 

assessments include a 2011 assessment for the use of dimethomorph on Grapes (D387380), and a 

2011 assessment on brassica subgroup 5A, 5B, and green onions (D387477, 387476). Appendix 

A lists the most recent usage information on dimethomorph uses. 

In addition, EFED considered the latest EPA science policies and risk assessment methodologies. 

The structure of dimethomorph, as well as the chemical names and other identifiers can be found 

in the chemical identity table attached to this document (Table 2). 

Dimethomorph is a systemic fungicide used to control molds on plants. It is a cinnamic acid 

derivative and a member of the morpholine chemical family. Its mode of action is the inhibition 

of sterol (ergosterol) synthesis. It is a mixture of two isomers (E and Z), but only the Z isomer 

has fungicidal activity. 

Dimethomorph is currently registered for use on a variety of agricultural food and feed crops, 

including Brassica leafy vegetables, bulb vegetables, cucurbit vegetables, fruiting vegetables, 

ginseng, grapes, hops, lettuce, lima beans, potatoes, taro, tobacco, field-grown tomatoes, and 

turnip greens. 

It is formulated in active end-use products as a water dispersible granule, and emulsifiable 

concentrate. Treatment equipment includes aircraft, ground equipment, high volume ground 

sprayer, ultra low volume ground sprayer, and low volume ground sprayer. The chemical 

profile produced by BEAD, located in the docket, lists the use patterns of maximum exposures 

for the current uses of Dimethomorph. EFED will use application scenarios that result in upper 

bound maximum exposure scenarios for a given use for the risk assessment. 

The major degradate of dimethomorph in submitted environmental fate studies was CO2 (aerobic 

soil metabolism, and anaerobic aerobic aquatic metabolism), and an unidentified degradate 

recovered at up to 16% of the applied radioactivity (aerobic and anaerobic aquatic metabolism). 

These unidentified residues will be added to the total toxic residue (TTR) to characterize their 

impact. Absence of data on these degradates will be adding an uncertainty to the risk assessment. 

Additional data such as (e.g. chemical structure, fate data) could reduce such uncertainty. 
Page 7 of 43 

2. Conclusions from Previous Risk Assessments 

2.1. Ecological Risk Assessments 

The Agency has conducted multiple ecological risk assessments on Dimethomorph that serve as 

a basis for this scoping document. These assessments are briefly summarized below. 

The most recent risk assessments for Dimethomorph are for the use revision of Dimethomorph 

on grapes (DP Barcode 387380) and the IR-4 Section 3 registration for use on Brassica head and 

stem subgroup 5A (DP Barcode 316329). The major ecological conclusions presented in these 

risk assessments were as follows: 

Table 1. Summary of Risk Concerns Identified for Dimethomorph in Previous Assessments

Bird

s 

Mammal

s 

Terr. 

Plant

s 

Terr. 

Invert

s 

Fish BC

F 

Aquati

c 

Inverts 

Aquati

c 

Plants 

Ground

water 

Contami

nation 

Persiste

nce 

Degradates of 

Concern 

√ a √ b --c

 --c √ d -- e -- c -- c No Yes Uncertain f 

a

 Chronic LOC exceeded for birds; no acute exceedances. b

 Chronic LOC exceeded for mammals based on dose-based effects; no acute exceedances. c

 No LOC exceedances 

d

 Chronic risk presumed for freshwater and estuarine/marine fish and aquatic-phase amphibians based on lack of 

data due to significant effects observed in all levels; no acute exceedances. e BCF data waived because Kow is <1000. f An unidentified degradate was recovered at 16% of radioactivity; however, was never assessed whether it is a 

degradate of concern or not. 

2.2. Drinking Water Exposure Assessments 

The latest Tier I drinking water exposure assessment for the proposed new use Brassica leafy, 

and bulb vegetables; and dimethomorph new use on leafy vegetables was conducted for 

Dimethomorph in 2011 (USEPA, 2011, D387377, D387371, D382099, D382109). That 

exposure assessment was conducted on the parent only since the degradates were deemed to not 

be of tox concern by HED. Tier I exposure estimates of Dimethomorph from currently labeled 

uses that produce maximum exposure (use on broccoli) were 24.7 μg/L for surface water and 

0.264 μg/L for ground water. 

2.3. Clean Water Act Programs 

Dimethomorph is not identified as a cause of impairment for any water bodies listed as impaired 

under section 303(d) of the Clean Water Act. No Total Maximum Daily Load (TMDL) criteria 

have been developed for Dimethomorph. Aquatic benchmarks have been established for 

Dimethomorph and are available at 

http://www.epa.gov/oppefed1/ecorisk_ders/aquatic_life_benchmark.htm. Any data submitted or 
Page 8 of 43 

otherwise located as part of the registration review process may be used to update aquatic life 

benchmarks if applicable. 

3. Environmental Fate and Transport 

Although the fate database is incomplete, a preliminary environmental fate assessment can 

be made. From acceptable and supplemental laboratory studies with Dimethomorph, it 

appears that microbial metabolism is the primary route of dissipation with reported 

laboratory aerobic soil metabolic half-lives of 66-117 days. No aerobic soil metabolism 

degradates were identified other than small amounts of 14CO2. As Dimethomorph degraded, 

most of the radioactivity was not extracted from the soil. While it is also clear that 

Dimethomorph will degrade in anaerobic soil and anaerobic aquatic systems, the rates cannot 

be determined at this time since the submitted studies had additional carbon sources which 

may have significantly accelerated the degradation rates. A pair of isomers of monodesmethyl Dimethomorph were isolated and identified as primary intermediates for the 

anaerobic studies. 

Dimethomorph did not hydrolyze or photodegrade in the submitted studies. Dimethomorph 

was shown to be moderately mobile to slightly mobile in soil. Mobility in German soils ( Kd

values were 2.09-1 1.67 ml/g and Koc values were 290-566). Mobility in the four selected 

USA soils has Kd values range of 10.1-19.0 ml/g, and Koc values range of 787-1588. 

Selection of environmental fate and transport properties of Dimethomorph is summarized in 

Table 2. 

Table 2. Chemical Properties and Environmental Fate Parameters of Dimethomorph.

Parameter Value Description Source

Selected Physical/Chemical Parameters

Molecular mass (molecular 

formula) 

387.86 g/mole 

Vapor pressure (20°C) E isomer 7.3 x 10-9 mmHg 

Z isomer 7.5 x 10-9 mmHg 

Non-volatile Tomlin (ed.) 

Aqueous solubility (20C) <50 mg/l at 20-23 deg C Low water solubility Tomlin (ed.) 

Henry’s Law Constant 2.06-2.13 x 10-10 atmm3/ 

Mole 

Non-volatile Estimated from vapor

pressure and water 

solubility 

Log octanol-to-water partition 

coefficient (Log KOW) 

2.68 Low hydrophobic Tomlin (ed.) 

Persistence 

Hydrolysis half-life (25C) @ 

pH 4, 7, and 9 

stable Stable at all pHs for 

a period of 10 weeks. 

MRID 

43917226 
Page 9 of 43 

Parameter Value Description Source

Aqueous photolysis half-life 

(pH 5, 25C) 

T1/2 = 50-56 days Value corresponds to 

12 hour photo cycle 

in midsummer, 

uncorrected half-life 

with continuous 

irradiation was 25-28 

days. 

MRID 

43917227 

Soil photolysis half-life (25C) T1/2 = 75 days Continuous 

irradiation (15 days) 

with a 

Xenon arc lamp. 

MRID 43917228 

Aerobic soil metabolism half-life 

(20°C) 

T1/2 = 66 days 

T1/2 = 117 days 

 MRID 43917229, 

MRID 43917230 

Anaerobic aquatic metabolism 

half-life (20C)

0.9, 1.3 (parent) days Supplemental study MRID 43917233 

Aerobic aquatic metabolism halflife (20C) 24.7-56.9 days Supplemental study MRID 

43917233 

48326905 

Mobility

Freundlich soil-water partition 

coefficients (Kd); 

4.47, 11.67, 2.09, 4.94, 

8.51, 2.72, 3.03, 15.7, 

10.1, 19.0, 11.9 

mL/g 

Various foreign 

soils. The last four 

readings were 

performed with 

domestic soils. 

MRID: 

46235734 

43917235 

44780202 

Organic carbon-normalized 

Freundlich coefficients (KFOC) 

566, 402, 290, 515, 377, 

388, 316, 1588, 1158, 

1485, 787 mL/goc

Moderate-slightly 

mobile 

MRID: 

46235734, 

43917235, 

44780202 

Field Dissipation

Terrestrial field dissipation halflife; leaching depth N/A No acceptable study MRID 

43917236-39 

43970304 

44996201 

Fish Bioconcentration

Fish bioconcentration factors 

(BCF); depuration rate

Not available No data were 

submitted 

Data requirement was 

waived because the 

Kow, is <1000 
Page 10 of 43 

 3.1. Transformation Products 

The major degradate of dimethomorph in submitted environmental fate studies was CO2 (aerobic 

soil metabolism, and anaerobic aerobic aquatic metabolism), and an unidentified degradate 

recovered at up to 16% of the applied radioactivity (aerobic and anaerobic aquatic metabolism). 

These unidentified residues will be added to the TTR to characterize their impact. Absence of 

data on these degradates will be adding an uncertainty to the risk assessment. Additional data 

such as (e.g. chemical structure, fate data) could reduce such uncertainty. 

Minor degradates were isolated, but no compounds were identified (aqueous photolysis and soil 

photolysis studies). 

4. Receptors 

Tables 3 and 4 provide a summary of the aquatic and terrestrial taxonomic groups, respectively, 

and most sensitive surrogate species tested to characterize the potential acute and chronic 

ecological effects of dimethomorph. In addition, the tables provide a preliminary overview of 

the potential acute toxicity of dimethomorph by providing the acute toxicity classifications. 

Based on the available ecotoxicity information, dimethomorph is moderately toxic to freshwater 

fish however caused no immobility to freshwater invertebrates up to 10.6 mg/L. Dimethomorph 

is also slightly toxic to estuarine/marine fish but moderately toxic to estuarine/marine 

invertebrates. On the terrestrial side, dimethomorph is practically non-toxic to birds, mammals, 

soil invertebrates, and terrestrial insects. More ecological studies for terrestrial and aquatic plants 

have been submitted since the last risk assessment; thus, the toxicity of dimethomorph to 

terrestrial and aquatic plants is being reviewed at this time. Additional detail is included in the 

following tables. 

4.1. Effects to Aquatic Organisms 

Table 3. Summary of the Most Sensitive Endpoints from Aquatic Toxicity Studies for 

Dimethomorph 

Taxonomic 

Group 

Study 

Type 

Surrogate 

Species 

Toxicity Value 

(mg a.i./L) 

Acute Toxicity 

Classification or 

Adverse Effect 

Observed 

Source 

(Study 

classification) 

Freshwater fish1

Acute Rainbow Trout 

(Oncorhynchus 

mykiss) 

LC50 = 6.2 Moderately toxic 43917211 

(Acceptable) 

Chronic NOAEC <0.341 Affected 

Endpoint: posthatch weight 

44418104 

(Supplemental) 

Freshwater 

invertebrates 

Acute 

Water Flea 

(Daphnia magna) 

EC50 >10.6 No effects up to 

10.6 mg a.i./L 

45507202 

(Supplemental) 

Chronic NOAEC = 0.11 

Affected 

Endpoint: length 

(growth) 

44418105 

(Acceptable) 

Estuarine/marine 

fish Acute Sheepshead Minnow LC50 = 11.3 Slightly toxic 44418101 

(Acceptable) 
Page 11 of 43 

Table 3. Summary of the Most Sensitive Endpoints from Aquatic Toxicity Studies for 

Dimethomorph 

Taxonomic 

Group 

Study 

Type 

Surrogate 

Species 

Toxicity Value 

(mg a.i./L) 

Acute Toxicity 

Classification or 

Adverse Effect 

Observed 

Source 

(Study 

classification) 

Chronic 

(Cyprinodon 

variegatus) NOAEC <0.063 

Affected 

Endpoint: time 

to hatch 

48326906 

(Supplemental) 

Estuarine/marine 

invertebrates 

Acute 

Eastern Oyster 

(Crassostrea 

virginica) 

EC50 = 5.13 Moderately toxic 44418102 

(Acceptable) 

Chronic No data available. 

Aquatic plants 

and algae 

Vascular Duckweed 

(Lemna gibba) -- -- Under review2

Nonvascular Algae or diatom -- -- Under review3

1 Freshwater fish may be surrogates for aquatic-phase amphibians. 

2 MRID 44283402 is currently under review to collect data on the most sensitive species and endpoints. MRID 

45507203 has been reviewed and will be compared to MRID 44283402 to select the most sensitive species and 

endpoints. 

3 MRIDs 43917217, 44283402, and 47700328 are currently under review to collect data on the most sensitive 

species and endpoints. MRIDs 43917222 and 45507204 have been reviewed and will be compared to the MRIDs 

under review to select the most sensitive species and endpoints. 

4.2. Effects to Terrestrial Organisms 

Table 4. Summary of the Most Sensitive Endpoints from Terrestrial Toxicity Studies for 

Dimethomorph 

Taxonomic 

Group 

Study 

Type 

Surrogate 

Species 

Toxicity Value Acute Toxicity 

Classification or 

Chronic Effects 

Observed 

Source 

(Study 

classification) 

Birds1

Acute 

Bobwhite quail 

(Colinus 

virginianus) 

LD50 > 2000 mg a.i./kgbw 

Practically nontoxic 43917206 

(Acceptable) 

Subacute 

Dietary 

LC50 > 5310 mg a.i./kgdiet Practically nontoxic 43917208 

(Acceptable) 

Chronic 

NOAEC = 200 mg 

a.i./kg-diet 

LOAEC = 800 mg 

a.i./kg-diet 

Affected 

Endpoint: 

hatchling weight 

and adult female 

weight 

44283403 

(Acceptable) 

Mammals 

Acute Oral 

Laboratory rat 

(Rattus 

norvegicus) 

LD50 = 3600 mg a.i./kgbw (Females) 

Practically nontoxic 44283402 

Chronic 

Laboratory rat 

(Rattus 

norvegicus) 

NOAEL = 300 mg 

a.i./kg-diet 

LOAEL = 1000 mg 

a.i./kg-diet 

Affected 

Endpoint: 

reproductive 

effects 

42333920 

Insects Acute 

Contact 

Honey bee 

(Apis mellifera L.) LD50 > 50 μg a.i./bee Practically nontoxic 

43917223 

(Acceptable) 
Page 12 of 43 

Table 4. Summary of the Most Sensitive Endpoints from Terrestrial Toxicity Studies for 

Dimethomorph 

Taxonomic 

Group 

Study 

Type 

Surrogate 

Species 

Toxicity Value Acute Toxicity 

Classification or 

Chronic Effects 

Observed 

Source 

(Study 

classification) 

Terrestrial 

plants 

Seedling 

Emergence 

Dicot -- -- Under review2

Monocot -- -- 

Vegetative 

Vigor 

Dicot -- -- Under review3

Monocot -- -- 1 Birds represent surrogates for terrestrial-phase amphibians and reptiles. 

2 MRID 47700329 is currently under review to collect data on the most sensitive species and endpoints. MRID 

44283401 has been reviewed and will be compared to the MRID 47700329 to select the most sensitive species and 

endpoints. 

3 MRID 47700328 is currently under review to collect data on the most sensitive species and endpoints. MRID 

44283401 has been reviewed and will be compared to MRID 47700328 to select the most sensitive species and 

endpoints.

4.3. Ecological Incidents 

The ecological incident information system (EIIS) is an OPP database that houses ecological 

incidents that have been reported to the Agency. When available, EIIS includes date and 

location of an incident, type and magnitude of effects observed in various species, use(s) of 

pesticides known or suspected of contributing to the incident, and results of any chemical residue 

analysis or other analyses conducted during incident investigation. EIIS incidents are 

categorized according to the certainty that the incident resulted from pesticide exposure. The 

Avian Monitoring System (AIMS) is a database administered by the American Bird Conservancy 

that contains publicly available data on reported avian incidents involving pesticides. Many of 

the incidents listed in this database are also in the EIIS. 

There are no reported incidents for dimethomorph in the EIIS or AIMS databases, as well as no 

reports of aggregate incidents as of October 2012. The absence of reported incidents should not 

be construed as the absence of incidents. Incident reports for non-target organisms typically 

provide information only on mortality events and plant damage. Sublethal effects in organisms 

such as abnormal behavior, reduced growth and/or impaired reproduction are rarely reported, 

except for some phytotoxic effects in terrestrial plants. EPA's changes in the registrant reporting 

requirements for incidents in 1998 may also account for a reduced number of reported incidents. 

5. Exposure Pathways of Concern 

The environmental fate and toxicity profile for Dimethomorph suggests that direct spray, spray 

drift, leaching and runoff represent the likely exposure pathways for terrestrial and aquatic nontarget organisms. Drinking water and inhalation exposure pathways were screened using the SIP 

(Screening Imbibition Program) and STIR (Screening Tool for Inhalation Risk) screening 

methods and were found to be exposure pathways of low concern (no LOC exceedances are 

expected). SIP and STIR are described in detail at: 

http://www.epa.gov/oppefed1/models/terrestrial/index.htm and the modeling can be found in the 

Appendix C. 
Page 13 of 43 

6. Analysis Plan 

6.1. Stressors of Concern 

Ecological Risk Assessment 

Based on available toxicity data, it appears that the only stressor of ecological concern for 

terrestrial and aquatic organisms is dimethomorph; however, an unidentified degradate recovered 

at up to 16% of the applied radioactivity was observed and no data on the unidentified degradate 

is available to determine whether the degradate is of concern or not. Therefore, all risk 

calculations will be based on two approaches to determine whether the unidentified degradate 

may be of potential concern: for parent dimethomorph alone (for terrestrial exposure) and for 

parent dimethomorph plus the unidentified degradate, assuming the degradate is stable and as 

toxic as the parent (for aquatic exposure). Absence of data on these degradates will be adding an 

uncertainty to the risk assessment. Additional data such as (e.g. chemical structure, fate data) 

could reduce such uncertainty. 

Drinking Water 

 

The drinking water assessments conducted to support future human health risk assessments of 

dimethomorph will incorporate model estimates of dimethomorph residues of concern, which is 

the parent compound only since the degradates were deemed to not be of tox concern by HED. 

If the registrant choose to submit data on parent and degradates, the chemical dimethomorph 

residues of concern may be reevaluated. 

6.2. Measures of Exposure 

EFED will use standard available models to evaluate potential exposures to aquatic and 

terrestrial organisms as described at http://www.epa.gov/pesticides/science/models_db.htm. 

6.3. Measures of Effect 

Toxicity data presented in Section 4 of this problem formulation will be used to calculate risk 

quotients. Any additional information submitted by the registrant or found in the open literature 

prior to conduct of the risk assessment also will be considered. The open literature studies are 

identified using EPA’s ECOTOXicology database (ECOTOX) (USEPA, 2007c), which employs 

a literature search engine for locating chemical toxicity data for aquatic life, terrestrial plants, 

and wildlife. The publically available database is available at www.epa.gov/ecotox/. The 

evaluation of both sources of data can also provide insight into the direct and indirect effects of 

pesticides on biotic communities from loss of species that are sensitive to the chemicals and from 

changes in structure and functional characteristics of the affected communities. 
Page 14 of 43 

6.4. Endangered Species Assessments 

Consistent with the Agency’s responsibility under the Endangered Species Act (ESA), the 

Agency will evaluate risks to Federally-listed threatened and/or endangered (listed) species from 

registered uses of pesticides in registration review. The process for evaluating potential risks to 

listed species is further described at 

http://www.epa.gov/oppfead1/endanger/litstatus/riskasses.htm. 

6.5. Endocrine Disruptor Screening Program 

Dimethomorph was not included in the first group of 67 chemicals issued an order to conduct 

Tier 1 EDSP testing. For additional information the EDSP program, visit 

http://www.epa.gov/endo/. 

7. Environmental Fate and Ecological Effects Data 

7.1. Environmental Fate 

Even though, the registrant did submit three studies (an aerobic soil metabolism MRID# 

48326903, 04, and aerobic aquatic metabolism study MRID# 48326905), the terrestrial field 

dissipation studies are still missing. The TFD is a keystone study that allows for direct 

comparison of the conceptual model of pesticide behavior derived from laboratory data with real 

world applications in the field. Without these data, EFED has no way to confirm that the 

predicted behavior will happen. However, without the TFD EFED will assume that the 

conceptual model built off of lab fate data is correct and reflect the real world condition of the 

TFD. 

Table 5 identifies environmental fate studies by MRID that offer data for each guideline 

requirement, as well as study classifications and whether or not further data are needed in order 

to support risk assessment. 

Table 5. Submitted Environmental Fate Data for Dimethomorph 

OCSPP Guideline Data 

Requirement 

Submitted 

Studies (MRID)

Study 

Classifications

Are data needed 

to conduct risk 

assessment? 

Justification and 

Assumptions EPA will 

Make in Absence of Data

835.2120 Hydrolysis MRID : 

43917226 

Acceptable No -- 

835.2240 Aqueous 

photolysis 

MRID 43917227 Acceptable No -- 

835.2410 Soil 

photolysis 

MRID 

43917228 

Acceptable No -- 
Page 15 of 43 

OCSPP Guideline Data 

Requirement 

Submitted 

Studies (MRID)

Study 

Classifications

Are data needed 

to conduct risk 

assessment? 

Justification and 

Assumptions EPA will 

Make in Absence of Data

835.4100 Aerobic soil 

metabolism 

MRID 

43917229 

43917230 

Acceptable No -- 

835.4200 Anaerobic 

soil 

metabolism 

MRID 

48326903 

48326904 

Supplemental No 

While anaerobic soil 

metabolism data are 

required according the 40 

CFR 158.1300, these data 

are not used in exposure. 

Therefore, these data would 

likely have little impact on 

the risk conclusions 

835.4300 Aerobic 

aquatic 

metabolism 

MRID 

43917233 

48326905 

Supplemental No Even though this study 

provides supplemental 

information towards the 

aerobic aquatic metabolism 

guideline; these data can be 

used in a quantitative RA 

835.4400 Anaerobic 

aquatic 

metabolism 

MRID 

43917233 

Supplemental No Even though this study 

provides supplemental 

information towards the 

aerobic aquatic metabolism 

guideline; these data can be 

used in a quantitative RA 

835.1230 

835.1240 

Adsorption/ 

desorption 

and leaching 

MRID: 

46235734, 

43917235, 

44780202 

Acceptable No -- 

835.6100 Terrestrial 

field 

dissipation 

MRID 

43917236-39 

43970304 

44996201 

Unacceptable Yes The TFD study allows for 

direct comparison of the 

conceptual model of 

pesticide behavior derived 

from laboratory data with 

real world applications in 

the field. Without these 

data, EFED has no way to 

confirm that the predicted 

behavior will happen. 

Storage 

Stability 

Study (TFD) 

44996201 Unacceptable 

850.1730 Fish 

bioconcentrat

ion 

MRID 44996202 Unacceptable No Data requirement was 

waived because the Kow, is 

<1000 
Page 16 of 43 

OCSPP Guideline Data 

Requirement 

Submitted 

Studies (MRID)

Study 

Classifications

Are data needed 

to conduct risk 

assessment? 

Justification and 

Assumptions EPA will 

Make in Absence of Data

Environmental 

Chemistry 

Method: Water 

850.6100 

Analytical 

method in 

water 

No data 

submitted 

NA Yes An ECM and ILV are 

needed with associated 

LOQ and LOD for all major 

degradates for water. In the 

absence of independently 

validated environmental 

chemistry methods, 

submitted environmental 

fate and ecological effects 

data may not be reviewable 

and entities outside the 

Agency may lack chemicalspecific methods for 

analyses in environmental 

compartments. 

Independently validated 

environmental chemistry 

methods will be used to 

evaluate any newly 

submitted environmental 

fate and ecological effects 

data and will be made 

available for enforcement 

and monitoring purposes at 

the federal, state, and local 

levels. 
Page 17 of 43 

OCSPP Guideline Data 

Requirement 

Submitted 

Studies (MRID)

Study 

Classifications

Are data needed 

to conduct risk 

assessment? 

Justification and 

Assumptions EPA will 

Make in Absence of Data

Environmental 

Chemistry 

Method: Soil 

850.6100 

Analytical 

method in 

soil 

No data 

submitted 

NA Yes An ECM and ILV are 

needed with associated 

LOQ and LOD for all major 

degradates for soil. In the 

absence of independently 

validated environmental 

chemistry methods, 

submitted environmental 

fate and ecological effects 

data may not be reviewable 

and entities outside the 

Agency may lack chemicalspecific methods for 

analyses in environmental 

compartments. 

Independently validated 

environmental chemistry 

methods will be used to 

evaluate any newly 

submitted environmental 

fate and ecological effects 

data and will be made 

available for enforcement 

and monitoring purposes at 

the federal, state, and local 

levels. 

Analytical 

method in 

aquatic 

media 

No data 

submitted 

NA 

7.2. Effects 

Tables 6 and 7 identify ecological effects studies by MRID that offer data for each guideline 

requirement, as well as study classifications and whether or not further data are needed in order 

to support risk assessment. Rationale for the additional data requested is presented below. 

 Dimethomorph has outdoor uses that may result in exposure to fish. Significant reductions in 

the post-hatch weight and hatchling success of freshwater (MRID 44418104) and 

estuarine/marine fish (MRID 48326906), respectively, were observed at all test levels as low 

as 34 and 63 μg a.i./L, respectively, that a No Effect concentration (NOAEC) could not be 

produced to assess the risk to fish on a chronic basis. A NOAEC of 25 μg a.i./L at the level 

of the modeled 60-day EEC from the FL cabbage scenario (D316329) would result in a LOC 

exceedance. An ELS study with freshwater fish, specifically the rainbow trout, is requested 

to be repeated with lower concentrations to produce an NOAEC. Currently, an ACR for 

estuarine/marine fish from the freshwater data is not appropriate because the acceptable acute 

and chronic studies used different freshwater species that prevented the calculations. Instead 

of asking for another ELS study using estuarine/marine fish with lower doses to produce an 
Page 18 of 43 

NOAEC to assess chronic risk to estuary fish, EFED is only asking that the rainbow trout 

ELS study be repeated with lower doses to produce an NOAEC in order to calculate an ACR 

using freshwater data on the same species (e.g., rainbow trout) to estimate the NOAEC for 

estuarine/marine fish. Without a repeated ELS study with the rainbow trout, chronic risk to 

both freshwater and estuarine/marine fish will be presumed. 

 Acceptable acute avian acute oral toxicity data were not submitted for a passerine species 

exposed to dimethomorph, which is now required under the 40 CFR Part 158 data 

requirements. However, in the most recent risk assessment that stated while the ‘RQ <0.15’ 

of a 20 gram, small-sized, bird that eat short grass exceeds the Agency’s acute listed species 

LOC of 0.1, this ‘RQ’ is expected to be lower than the LOC because none of the other bird 

RQs exceeded the LOC and a non-definitive endpoint (i.e., LD50 value >2,000 mg/kg-bw) 

based on the bobwhite quail was used to calculate that ‘RQ’ which resulted in exceeding the 

LOC where no mortality or other signs of toxicity were observed at the highest level tested. 

Though the available bobwhite quail study indicates dimethomorph has low toxicity to 

upland game bird species, it is uncertain whether passerines may be more or less sensitive to 

this chemical as a result of their higher metabolic rate and differing metabolic pathways. 

Given the predicted ‘RQ’ of <0.15 that exceeded the LOC for small-sized birds, EFED 

cannot preclude the potential risk to passerines which are small-sized birds. An avian oral 

toxicity study is needed for a passerine species. A passerine study protocol must be submitted 

for review by the Agency prior to initiation of the study. 

Table 6. Submitted Aquatic Ecological Effects Data for Dimethomorph 

OCSPP 

Guideline 

Data 

Requirement 

Submitted 

Studies 

(MRID) 

Study 

Classifications 

Are data 

needed to 

conduct risk 

assessment? 

Justification and Assumptions 

EPA will Make in Absence of 

Data 

 850.1010 Freshwater 

invertebrate 

acute toxicity 

45507202 

43917213 

47700317 

Supplemental 

Invalid 

Under review 

No -- 

850.1025 

850.1035 

 

Estuarine/Marine 

invertebrate 

acute toxicity 

44418102 

44418103 

Acceptable 

Supplemental 

No -- 

 850.1075 Freshwater fish 

acute toxicity 

43917211 

43917209 

43917210 

45507201 

47700316 

Acceptable 

Invalid 

Supplemental 

Supplemental 

Under review 

No -- 

 850.1075 Estuarine/Marine 

fish acute toxicity 

44418101 Acceptable No -- 

 850.1300 Freshwater 

invertebrate 

life cycle 

44418105 

43917214 

43917229 

Acceptable 

Supplemental 

Invalid 

No -- 
Page 19 of 43 

Table 6. Submitted Aquatic Ecological Effects Data for Dimethomorph 

OCSPP 

Guideline 

Data 

Requirement 

Submitted 

Studies 

(MRID) 

Study 

Classifications 

Are data 

needed to 

conduct risk 

assessment? 

Justification and Assumptions 

EPA will Make in Absence of 

Data 

 850.1350 Estuarine/Marine 

invertebrates 

life cycle 

(None) N/A No No data is available for 

estuarine/marine invertebrates. 

However, EFED is not asking for 

a chronic study and will use the 

freshwater data to make a 

conservative assumption of 

sensitivity for estuarine/marine 

invertebrates 

 850.1400 Freshwater fish 

early-life stage 

44418104 

45765501 

Supplemental 

Acceptable 

Yes An early-life stage fish study 

with specifically the rainbow 

trout at lower doses is necessary 

for risk assessment. Without 

data, risk would be presumed 

for freshwater fish, including 

listed species. 

 850.1400 Estuarine/Marine 

fish early-life 

stage 

48326906 Supplemental No An early-life stage study with 

sheepshead minnow at lower 

doses is necessary for risk 

assessment since a NOAEC could 

not be determined. However, 

EFED is not asking for another 

study and will use the freshwater 

data to make a conservative 

assumption of sensitivity for 

estuarine/marine fish. 

 850.1500 Fish life cycle (None) (N/A) No -- 

850.4400 Aquatic plant 

growth: 

Tier II vascular 

plants 

45507203 

44283402 

Acceptable 

Under review 

No Additional data are not requested 

at this time. A review on the 

newly submitted aquatic plant 

studies since the last risk 

assessment is conducted to 

evaluate whether the new 

endpoints are more sensitive than 

the previous studies. If the new 

studies are found to be less 

sensitive, the available endpoints 

used in previous risk assessments 

will remain unchanged. 

850.5400 Aquatic Plant 

Growth: 

Tier II algae 

43917222 

45507204 

43917217 

44283402 

47700315 

Acceptable 

Invalid 

Under review 

Under review 

Under review 

No 
Page 20 of 43 

Table 7. Submitted Terrestrial Ecological Effects Data for Dimethomorph

OCSPP 

Guideline 

Data 

Requirement 

Submitted 

Studies 

(MRID) 

Study 

Classifications 

Are data 

needed for 

risk 

assessment? 

Current Additional Data Need 

 850.2100 Avian oral 

toxicity 

43917205 

43917206 

47700314 

Acceptable 

Acceptable 

Under review 

Yes A passerine bird study is 

necessary to satisfy standard 

data requirement. Without data, 

risk would be presumed for 

small-sized birds, including 

listed species. 

 850.2200 Avian dietary 

toxicity 

43917207 

43917208 

Acceptable 

Acceptable 

No -- 

 850.2300 Avian 

reproduction 

44283403 

44283404 

Acceptable 

Supplemental 

No -- 

Nonguideline Avian 

inhalation 

(None) (N/A) No -- 

 850.3020 Honey bee 

acute contact 

toxicity 

43917223 

47700318 

Acceptable 

Under review 

No -- 

850.3030 Honey bee 

residue on 

foliage 

(None) (N/A) No -- 

 850.3040 Field testing 

for pollinators 

(None) (N/A) No -- 

850.4100 Terrestrial 

plant toxicity: 

Tier I or II 

seedling 

emergence 

44283401 

47700329 

Acceptable 

Under review 

No Additional data are not requested 

at this time. A review on the 

newly submitted terrestrial plant 

studies since the last risk 

assessment is conducted to 

evaluate whether the new 

endpoints are more sensitive than 

the previous studies. If the new 

studies are found to be less 

sensitive, the available endpoints 

used in previous risk assessments 

will remain unchanged. 

850.4150 Terrestrial 

plant toxicity: 

Tier I or II 

vegetative 

vigor 

44283401 

47700328 

Acceptable 

Under review 

No 
Page 21 of 43 

8. References 

Tomlin, C.D.S. (ed.). The Pesticide Manual - World Compendium, 11th ed., British Crop 

Protection Council, Surrey, England 1997, p. 416. 

USEPA 2011. EFED Drinking Water Assessment for: The amended directions for use of 

Dimethomorph in Brassica leafy, and bulb vegetables; and dimethomorph new use on leafy vegetables; 

and new ai Ametoctradin coformulated with dimethomorph for Use in Human Health Risk Assessment. 

D387377, 387371, 382099, 382109, July 25, 2011. 

USEPA 2006. EFED IR-4 Registration for Dimethomorph (ACROBAT 50WP) for use on Brassica 

Head and Stem Subgroup to control blight (Phytophthora ssp) and downy mildew (Pseudoperonospora 

cubensis). D316329. October 6, 2006. 

USEPA 2011. Revised Ecological Risk Assessment for the Proposed National use of Dimethomorph on 

Grape. D387380. December 13, 2011.
Page 22 of 43 

Appendices

Appendix A. 

Summary of Dimethomorph Use Information 

Use Site 

Application 

Method 

Type Desc 

Formulat

ion Desc 

Maximum 

Single 

Application 

Rate 

Max # 

Apps 

/ CC 

A. I. 

Max 

App 

Rate/C

C 

Max # 

Apps / 

Year 

A. I. 

Max 

App 

Rate/Y

ear 

Minimum 

Retreatme

nt Interval 

BEANS, SUCCULENT (LIMA) Broadcast. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 5 

.9777 lb 

/ a NS NS 7 d 

BEANS, SUCCULENT (LIMA) Broadcast. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 5 

.9777 lb 

/ a NS NS 7 d 

BEANS, SUCCULENT (LIMA) Chemigation. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 5 

.9777 lb 

/ a NS NS 7 d 

BRASSICA (HEAD AND 

STEM) VEGETABLES Broadcast. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 3 

.9777 lb 

/ a NS NS 7 d 

BRASSICA (HEAD AND 

STEM) VEGETABLES Broadcast. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 3 

.9777 lb 

/ a NS NS 7 d 

BRASSICA (HEAD AND 

STEM) VEGETABLES Chemigation. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 3 

.9777 lb 

/ a NS NS 7 d 

BULB VEGETABLES Broadcast. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 3 

.9777 lb 

/ a NS NS 5 d 

BULB VEGETABLES Broadcast. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL

E) .195 lb / a 5 

.975 lb / 

a NS NS 14 d 

BULB VEGETABLES Broadcast. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 3 

.9777 lb 

/ a NS NS 5 d 

BULB VEGETABLES Broadcast. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL

E) .195 lb / a 5 

.975 lb / 

a NS NS 14 d 

BULB VEGETABLES Chemigation. 

EMULSIFI

ABLE 

CONCENT .1955 lb / a 3 

.9777 lb 

/ a NS NS 5 d 
Page 23 of 43 

RATE 

BULB VEGETABLES Chemigation. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL

E) .195 lb / a 5 

.975 lb / 

a NS NS 14 d 

CONIFERS 

(PLANTATIONS/NURSERIES) Chemigation. 

EMULSIFI

ABLE 

CONCENT

RATE 

.1995 lb / 100 

gal NS NS NS NS 28 d 

CONIFERS 

(PLANTATIONS/NURSERIES) 

Directed 

spray. 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 50 

gal NS NS NS NS 10 d 

CONIFERS 

(PLANTATIONS/NURSERIES) 

High volume 

spray (dilute). 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 100 

gal NS NS NS NS 10 d 

CONIFERS 

(PLANTATIONS/NURSERIES) 

Hydroponic 

treatment. 

EMULSIFI

ABLE 

CONCENT

RATE 

.1995 lb / 100 

gal NS NS NS NS 14 d 

CONIFERS 

(PLANTATIONS/NURSERIES) 

Low volume 

spray 

(concentrate). 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 100 

gal NS NS NS NS 10 d 

CONIFERS 

(PLANTATIONS/NURSERIES) 

Soil drench 

treatment. 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 50 

gal NS NS NS NS 10 d 

CONIFERS 

(PLANTATIONS/NURSERIES) 

Ultra low 

volume. 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 100 

gal NS NS NS NS 10 d 

CUCURBIT VEGETABLES Broadcast. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL

E) .195 lb / a 4 

.78 lb / 

a NS NS 7 d 

CUCURBIT VEGETABLES Broadcast. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL

E) .195 lb / a 4 

.78 lb / 

a NS NS 7 d 

CUCURBIT VEGETABLES Chemigation. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL

E) .195 lb / a 4 

.78 lb / 

a NS NS 7 d 

FRUITING VEGETABLES Broadcast. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL

E) .195 lb / a 5 

.975 lb / 

a NS NS 7 d 

FRUITING VEGETABLES Broadcast. 

WATER 

DISPERSI

BLE 

GRANULE .195 lb / a 5 

.975 lb / 

a NS NS 7 d 
Page 24 of 43 

S (DRY 

FLOWABL

E) 

FRUITING VEGETABLES Chemigation. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL

E) .195 lb / a 5 

.975 lb / 

a NS NS 7 d 

GINSENG (MEDICINAL) Broadcast. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 5 

.9777 lb 

/ a NS NS 7 d 

GINSENG (MEDICINAL) Chemigation. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 5 

.9777 lb 

/ a NS NS 7 d 

GINSENG (MEDICINAL) Broadcast. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 5 

.9777 lb 

/ a NS NS 7 d 

GINSENG (MEDICINAL) Chemigation. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 5 

.9777 lb 

/ a NS NS 7 d 

GRAPES Broadcast. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 4 

.9777 lb 

/ a NS NS 7 d 

GRAPES Broadcast. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 4 

.9777 lb 

/ a NS NS 7 d 

GRAPES Chemigation. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 4 

.9777 lb 

/ a NS NS 7 d 

HOPS Broadcast. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 3 

.5866 lb 

/ a NS NS 10 d 

HOPS Chemigation. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 3 

.5866 lb 

/ a NS NS 10 d 

HOPS Broadcast. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 3 

.5866 lb 

/ a NS NS 10 d 

HOPS Chemigation. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 3 

.5866 lb 

/ a NS NS 10 d 

LEAFY VEGETABLES Broadcast. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 3 

.9777 lb 

/ a NS NS 7 d 

LEAFY VEGETABLES Broadcast. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 3 

.9777 lb 

/ a NS NS 7 d 

LEAFY VEGETABLES Chemigation. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 3 

.9777 lb 

/ a NS NS 7 d 

ORNAMENTAL AND/OR 

SHADE TREES Spray. 

WETTABL

E .2025 lb / a NS 

1.0125 

lb / a 20/YR NS 7 d 
Page 25 of 43 

POWDER 

ORNAMENTAL AND/OR 

SHADE TREES Chemigation. 

EMULSIFI

ABLE 

CONCENT

RATE 

.1995 lb / 100 

gal NS NS NS NS 28 d 

ORNAMENTAL AND/OR 

SHADE TREES Chemigation. 

WETTABL

E 

POWDER .2 lb / 100 gal NS NS NS NS 28 d 

ORNAMENTAL AND/OR 

SHADE TREES 

Directed 

spray. 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 50 

gal NS NS NS NS 10 d 

ORNAMENTAL AND/OR 

SHADE TREES 

Directed 

spray. 

WETTABL

E 

POWDER .4 lb / 50 gal NS NS NS NS 10 d 

ORNAMENTAL AND/OR 

SHADE TREES Drench. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL

E) .2025 lb / a NS NS 20/YR NS 7 d 

ORNAMENTAL AND/OR 

SHADE TREES 

High volume 

spray (dilute). 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 100 

gal NS NS NS NS 10 d 

ORNAMENTAL AND/OR 

SHADE TREES 

High volume 

spray (dilute). 

WETTABL

E 

POWDER .4 lb / 100 gal NS NS NS NS 10 d 

ORNAMENTAL AND/OR 

SHADE TREES 

Hydroponic 

treatment. 

EMULSIFI

ABLE 

CONCENT

RATE 

.1995 lb / 100 

gal NS NS NS NS 14 d 

ORNAMENTAL AND/OR 

SHADE TREES 

Hydroponic 

treatment. 

WETTABL

E 

POWDER .2 lb / 100 gal NS NS NS NS 14 d 

ORNAMENTAL AND/OR 

SHADE TREES 

Low volume 

spray 

(concentrate). 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 100 

gal NS NS NS NS 10 d 

ORNAMENTAL AND/OR 

SHADE TREES 

Low volume 

spray 

(concentrate). 

WETTABL

E 

POWDER .4 lb / 100 gal NS NS NS NS 10 d 

ORNAMENTAL AND/OR 

SHADE TREES 

Soil drench 

treatment. 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 50 

gal NS NS NS NS 10 d 

ORNAMENTAL AND/OR 

SHADE TREES 

Soil drench 

treatment. 

WETTABL

E 

POWDER .4 lb / 50 gal NS NS NS NS 10 d 

ORNAMENTAL AND/OR 

SHADE TREES Spray. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL

E) .2025 lb / a NS NS 20/YR NS 7 d 

ORNAMENTAL AND/OR 

SHADE TREES Spray. 

WETTABL

E 

POWDER .2025 lb / a NS 

1.0125 

lb / a 20/YR NS 7 d 

ORNAMENTAL AND/OR 

SHADE TREES 

Ultra low 

volume. 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 100 

gal NS NS NS NS 10 d 

ORNAMENTAL AND/OR 

SHADE TREES 

Ultra low 

volume. 

WETTABL

E 

POWDER .4 lb / 100 gal NS NS NS NS 10 d 
Page 26 of 43 

ORNAMENTAL GROUND 

COVER Chemigation. 

EMULSIFI

ABLE 

CONCENT

RATE 

.1995 lb / 100 

gal NS NS NS NS 28 d 

ORNAMENTAL GROUND 

COVER 

Directed 

spray. 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 50 

gal NS NS NS NS 10 d 

ORNAMENTAL GROUND 

COVER 

High volume 

spray (dilute). 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 100 

gal NS NS NS NS 10 d 

ORNAMENTAL GROUND 

COVER 

Hydroponic 

treatment. 

EMULSIFI

ABLE 

CONCENT

RATE 

.1995 lb / 100 

gal NS NS NS NS 14 d 

ORNAMENTAL GROUND 

COVER 

Low volume 

spray 

(concentrate). 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 100 

gal NS NS NS NS 10 d 

ORNAMENTAL GROUND 

COVER 

Soil drench 

treatment. 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 50 

gal NS NS NS NS 10 d 

ORNAMENTAL GROUND 

COVER 

Ultra low 

volume. 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 100 

gal NS NS NS NS 10 d 

ORNAMENTAL 

HERBACEOUS PLANTS Spray. 

WETTABL

E 

POWDER .2025 lb / a NS 

1.0125 

lb / a 20/YR NS 7 d 

ORNAMENTAL 

HERBACEOUS PLANTS Chemigation. 

EMULSIFI

ABLE 

CONCENT

RATE 

.1995 lb / 100 

gal NS NS NS NS 28 d 

ORNAMENTAL 

HERBACEOUS PLANTS Chemigation. 

WETTABL

E 

POWDER .2 lb / 100 gal NS NS NS NS 28 d 

ORNAMENTAL 

HERBACEOUS PLANTS 

Directed 

spray. 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 50 

gal NS NS NS NS 10 d 

ORNAMENTAL 

HERBACEOUS PLANTS 

Directed 

spray. 

WETTABL

E 

POWDER .4 lb / 50 gal NS NS NS NS 10 d 

ORNAMENTAL 

HERBACEOUS PLANTS Drench. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL

E) .2025 lb / a NS NS 20/YR NS 7 d 

ORNAMENTAL 

HERBACEOUS PLANTS 

High volume 

spray (dilute). 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 100 

gal NS NS NS NS 10 d 

ORNAMENTAL 

HERBACEOUS PLANTS 

High volume 

spray (dilute). 

WETTABL

E 

POWDER .4 lb / 100 gal NS NS NS NS 10 d 

ORNAMENTAL 

HERBACEOUS PLANTS 

Hydroponic 

treatment. 

EMULSIFI

ABLE 

CONCENT

RATE 

.1995 lb / 100 

gal NS NS NS NS 14 d 

ORNAMENTAL 

HERBACEOUS PLANTS 

Hydroponic 

treatment. 

WETTABL

E 

POWDER .2 lb / 100 gal NS NS NS NS 14 d 

ORNAMENTAL 

HERBACEOUS PLANTS 

Low volume 

spray 

(concentrate). 

EMULSIFI

ABLE 

CONCENT

.3992 lb / 100 

gal NS NS NS NS 10 d 
Page 27 of 43 

RATE 

ORNAMENTAL 

HERBACEOUS PLANTS 

Low volume 

spray 

(concentrate). 

WETTABL

E 

POWDER .4 lb / 100 gal NS NS NS NS 10 d 

ORNAMENTAL 

HERBACEOUS PLANTS 

Soil drench 

treatment. 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 50 

gal NS NS NS NS 10 d 

ORNAMENTAL 

HERBACEOUS PLANTS 

Soil drench 

treatment. 

WETTABL

E 

POWDER .4 lb / 50 gal NS NS NS NS 10 d 

ORNAMENTAL 

HERBACEOUS PLANTS Spray. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL

E) .2025 lb / a NS NS 20/YR NS 7 d 

ORNAMENTAL 

HERBACEOUS PLANTS Spray. 

WETTABL

E 

POWDER .2025 lb / a NS 

1.0125 

lb / a 20/YR NS 7 d 

ORNAMENTAL 

HERBACEOUS PLANTS 

Ultra low 

volume. 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 100 

gal NS NS NS NS 10 d 

ORNAMENTAL 

HERBACEOUS PLANTS 

Ultra low 

volume. 

WETTABL

E 

POWDER .4 lb / 100 gal NS NS NS NS 10 d 

ORNAMENTAL 

NONFLOWERING PLANTS Chemigation. 

EMULSIFI

ABLE 

CONCENT

RATE 

.1995 lb / 100 

gal NS NS NS NS 28 d 

ORNAMENTAL 

NONFLOWERING PLANTS Chemigation. 

WETTABL

E 

POWDER .2 lb / 100 gal NS NS NS NS 28 d 

ORNAMENTAL 

NONFLOWERING PLANTS 

Directed 

spray. 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 50 

gal NS NS NS NS 10 d 

ORNAMENTAL 

NONFLOWERING PLANTS 

Directed 

spray. 

WETTABL

E 

POWDER .4 lb / 50 gal NS NS NS NS 10 d 

ORNAMENTAL 

NONFLOWERING PLANTS 

High volume 

spray (dilute). 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 100 

gal NS NS NS NS 10 d 

ORNAMENTAL 

NONFLOWERING PLANTS 

High volume 

spray (dilute). 

WETTABL

E 

POWDER .4 lb / 100 gal NS NS NS NS 10 d 

ORNAMENTAL 

NONFLOWERING PLANTS 

Hydroponic 

treatment. 

EMULSIFI

ABLE 

CONCENT

RATE 

.1995 lb / 100 

gal NS NS NS NS 14 d 

ORNAMENTAL 

NONFLOWERING PLANTS 

Hydroponic 

treatment. 

WETTABL

E 

POWDER .2 lb / 100 gal NS NS NS NS 14 d 

ORNAMENTAL 

NONFLOWERING PLANTS 

Low volume 

spray 

(concentrate). 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 100 

gal NS NS NS NS 10 d 

ORNAMENTAL 

NONFLOWERING PLANTS 

Low volume 

spray 

(concentrate). 

WETTABL

E 

POWDER .4 lb / 100 gal NS NS NS NS 10 d 

ORNAMENTAL 

NONFLOWERING PLANTS 

Soil drench 

treatment. 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 50 

gal NS NS NS NS 10 d 
Page 28 of 43 

ORNAMENTAL 

NONFLOWERING PLANTS 

Soil drench 

treatment. 

WETTABL

E 

POWDER .4 lb / 50 gal NS NS NS NS 10 d 

ORNAMENTAL 

NONFLOWERING PLANTS 

Ultra low 

volume. 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 100 

gal NS NS NS NS 10 d 

ORNAMENTAL 

NONFLOWERING PLANTS 

Ultra low 

volume. 

WETTABL

E 

POWDER .4 lb / 100 gal NS NS NS NS 10 d 

ORNAMENTAL WOODY 

SHRUBS AND VINES Spray. 

WETTABL

E 

POWDER .2025 lb / a NS 

1.0125 

lb / a 20/YR NS 7 d 

ORNAMENTAL WOODY 

SHRUBS AND VINES Chemigation. 

EMULSIFI

ABLE 

CONCENT

RATE 

.1995 lb / 100 

gal NS NS NS NS 28 d 

ORNAMENTAL WOODY 

SHRUBS AND VINES Chemigation. 

WETTABL

E 

POWDER .2 lb / 100 gal NS NS NS NS 28 d 

ORNAMENTAL WOODY 

SHRUBS AND VINES 

Directed 

spray. 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 50 

gal NS NS NS NS 10 d 

ORNAMENTAL WOODY 

SHRUBS AND VINES 

Directed 

spray. 

WETTABL

E 

POWDER .4 lb / 50 gal NS NS NS NS 10 d 

ORNAMENTAL WOODY 

SHRUBS AND VINES Drench. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL

E) .2025 lb / a NS NS 20/YR NS 7 d 

ORNAMENTAL WOODY 

SHRUBS AND VINES 

High volume 

spray (dilute). 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 100 

gal NS NS NS NS 10 d 

ORNAMENTAL WOODY 

SHRUBS AND VINES 

High volume 

spray (dilute). 

WETTABL

E 

POWDER .4 lb / 100 gal NS NS NS NS 10 d 

ORNAMENTAL WOODY 

SHRUBS AND VINES 

Hydroponic 

treatment. 

EMULSIFI

ABLE 

CONCENT

RATE 

.1995 lb / 100 

gal NS NS NS NS 14 d 

ORNAMENTAL WOODY 

SHRUBS AND VINES 

Hydroponic 

treatment. 

WETTABL

E 

POWDER .2 lb / 100 gal NS NS NS NS 14 d 

ORNAMENTAL WOODY 

SHRUBS AND VINES 

Low volume 

spray 

(concentrate). 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 100 

gal NS NS NS NS 10 d 

ORNAMENTAL WOODY 

SHRUBS AND VINES 

Low volume 

spray 

(concentrate). 

WETTABL

E 

POWDER .4 lb / 100 gal NS NS NS NS 10 d 

ORNAMENTAL WOODY 

SHRUBS AND VINES 

Soil drench 

treatment. 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 50 

gal NS NS NS NS 10 d 

ORNAMENTAL WOODY 

SHRUBS AND VINES 

Soil drench 

treatment. 

WETTABL

E 

POWDER .4 lb / 50 gal NS NS NS NS 10 d 

ORNAMENTAL WOODY 

SHRUBS AND VINES Spray. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL

E) .2025 lb / a NS NS 20/YR NS 7 d 
Page 29 of 43 

ORNAMENTAL WOODY 

SHRUBS AND VINES Spray. 

WETTABL

E 

POWDER .2025 lb / a NS 

1.0125 

lb / a 20/YR NS 7 d 

ORNAMENTAL WOODY 

SHRUBS AND VINES 

Ultra low 

volume. 

EMULSIFI

ABLE 

CONCENT

RATE 

.3992 lb / 100 

gal NS NS NS NS 10 d 

ORNAMENTAL WOODY 

SHRUBS AND VINES 

Ultra low 

volume. 

WETTABL

E 

POWDER .4 lb / 100 gal NS NS NS NS 10 d 

POTATO, WHITE/IRISH Broadcast. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a NS 

.9777 lb 

/ a NS NS 5 d 

POTATO, WHITE/IRISH Broadcast. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL

E) .195 lb / a 5 

.975 lb / 

a NS NS 7 d 

POTATO, WHITE/IRISH Spray. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL

E) .2025 lb / a NS 

1.0125 

lb / a NS NS 5 d 

POTATO, WHITE/IRISH Spray. 

WETTABL

E 

POWDER .2025 lb / a NS 

1.0125 

lb / a NS NS 5 d 

POTATO, WHITE/IRISH Broadcast. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a NS 

.9777 lb 

/ a NS NS 5 d 

POTATO, WHITE/IRISH Broadcast. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL

E) .195 lb / a 5 

.975 lb / 

a NS NS 7 d 

POTATO, WHITE/IRISH Chemigation. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a NS 

.9777 lb 

/ a NS NS 5 d 

POTATO, WHITE/IRISH Chemigation. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL

E) .195 lb / a 5 

.975 lb / 

a NS NS 7 d 

POTATO, WHITE/IRISH Chemigation. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL

E) .2025 lb / a NS 

1.0125 

lb / a NS NS 5 d 

POTATO, WHITE/IRISH Chemigation. 

WETTABL

E 

POWDER .2025 lb / a NS 

1.0125 

lb / a NS NS 5 d 

POTATO, WHITE/IRISH Spray. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL .2025 lb / a NS 

1.0125 

lb / a NS NS 5 d 
Page 30 of 43 

E) 

POTATO, WHITE/IRISH Spray. 

WETTABL

E 

POWDER .2025 lb / a NS 

1.0125 

lb / a NS NS 5 d 

TARO Broadcast. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 5 

.9777 lb 

/ a NS NS 7 d 

TARO Broadcast. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 5 

.9777 lb 

/ a NS NS 7 d 

TARO Chemigation. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 5 

.9777 lb 

/ a NS NS 7 d 

TOMATO Broadcast. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a NS 

.9777 lb 

/ a NS NS 5 d 

TOMATO Broadcast. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL

E) .195 lb / a 5 

.975 lb / 

a NS NS 7 d 

TOMATO Broadcast. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a NS 

.9777 lb 

/ a NS NS 5 d 

TOMATO Broadcast. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL

E) .195 lb / a 5 

.975 lb / 

a NS NS 7 d 

TOMATO Chemigation. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a NS 

.9777 lb 

/ a NS NS 5 d 

TOMATO Chemigation. 

WATER 

DISPERSI

BLE 

GRANULE

S (DRY 

FLOWABL

E) .195 lb / a 5 

.975 lb / 

a NS NS 7 d 

TURNIP (GREENS) Broadcast. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 5 

.9777 lb 

/ a NS NS 7 d 

TURNIP (GREENS) Broadcast. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 5 

.9777 lb 

/ a NS NS 7 d 

TURNIP (GREENS) Chemigation. 

EMULSIFI

ABLE 

CONCENT

RATE .1955 lb / a 5 

.9777 lb 

/ a NS NS 7 d 
Page 31 of 43 

Appendix B. OPPIN Bibliography 

268800 Dimethomorph Eco Effects Bibliography 9/14/11 

850.2100 Avian Acute Oral Toxicity 

MRID Citation Reference 

47700314 Zok, S. (2008) BAS 651 00 F - Acute Toxicity in the Bobwhite Quail (Colinus 

virginianus) After Single Oral Administration (LD50). Project Number: 

2008/1003798/OCR, 2008/1003798, 11W0166/065062. Unpublished study prepared by 

BASF Aktiengesellschaft. 44 p. 

43917205 Phillips, C.; Roberts, N. (1996) The Acute Oral Toxicity (LD50) of CME to the Mallard 

Duck: (Amended Report): Lab Project Number: CMK 15/86919. Unpublished study 

prepared by Huntingdon Research Centre, Ltd. 20 p. 

43917206 Roberts, N.; Phillips, C. (1996) The Acute Oral Toxicity (LD50) of CME 151 to the 

Bobwhite Quail: (Amended Report): Lab Project Number: CMK 14/861226. 

Unpublished study prepared by Huntingdon Research Centre, Ltd. 22 p. 

850.2200 Avian Dietary Toxicity 

MRID Citation Reference 

43917207 Phillips, C.; Roberts, N.; Anderson, A. et al. (1996) The Dietary Toxicity (LD50) of CME 

151 to the Mallard Duck: (Amended Report): Lab Project Number: CMK 19/871028. 

Unpublished study prepared by Huntingdon Research Centre, Ltd. 33 p. 

43917208 Phillips, C.; Roberts, N.; Anderson, A. et al. (1996) The Dietary Toxicity (LD50) of CME 

151 to the Bobwhite Quail: (Amended Report): Lab Project Number: CMK 18/871027. 

Unpublished study prepared by Huntingdon Research Centre, Ltd. 33 p. 

850.2300 Avian Reproduction 

MRID Citation Reference 

44283403 Troup, R.; Christensen, G.; Taliaferro, M.; et al. (1997) Pilot Dietary Toxicity and Avian 

Reproduction Studies with Dimethomorph Technical (CL 336379) in the Northern 

Bobwhite (Colinus virginianus): Lab Project Number: 954-96-169: 954-96-170: 954-96-

165. Unpublished study prepared by EBA, Inc. 575 p. 

44283404 Troup, R.; Taliaferro, M.; Miller, V. (1997) Pilot Dietary Toxicity and Avian 

Reproduction Studies with Dimethomorph Technical (CL 336379) in the Mallard Duck 

(Anas platyrhynchos): Lab Project Number: 954-96-167: 954-96-168: CY-151. 

Unpublished study prepared by EBA, Inc. 532 p. 

850.1075 Fish Acute Toxicity, Freshwater and Estuarine/Marine 

MRID Citation Reference 

46818701 Jatzek, J. (2006) BAS 551 09 F: Acute Toxicity Study on the Rainbow Trout 

(Onchorhynchus mykiss) in a Static System over 96 Hours. Project Number: 

12F0411/045074, 2006/1010690. Unpublished study prepared by BASF 
Page 32 of 43 

Aktiengesellschaft, Experimental Toxicology and Ecology. 45 p. 

47700316 Zok, S. (2007) BAS 651 00 F - Acute Toxicity Study on the Rainbow Trout 

(Oncorhynchus mykiss) in a Static System over 96 Hours. Project Number: 

2007/1018902/OCR, 2007/1018902, 12F0166/065037. Unpublished study prepared by 

BASF Aktiengesellschaft. 48 p. 

43917209 Douglas, M.; Handley, J.; MacDonald, I. (1996) The Acute Toxicity of CME 151 to 

Bluegill Sunfish (Lepomis macrochirus): (Amended Report): Lab Project Number: CMK 

28/88229. Unpublished study prepared by Huntingdon Research Centre, Ltd. 22 p. 

43917210 Ellgehausen, H.; Vogel, W. (1986) 96-Hour Acute Toxicity Study (LD50) with CME 151 

in the Carp: Lab Project Number: 068163. Unpublished study prepared by R C C 

Umweltchemie AG. 33 p. 

43917211 Ellgehausen, H.; Vogel, W. (1986) 96-Hour Acute Toxicity Study (LC50) with CME 151 

in the Rainbow Trout: Lab Project Number: 068152. Unpublished study prepared by R C 

C Umweltchemie AG. 33 p. 

43917215 Toy, R. (1991) CME 151/Mancozeb 90/600 g/kg WP (SYS50586): Acute Toxicity to 

Salmo Gairdneri and Daphnia magna: Lab Project Number: SBGR.90.159: 4467. 

Unpublished study prepared by Shell Research Ltd. 37 p. 

43917216 Toy, R.; Gray, A. (1991) Dimethomorph: CME 151/Mancozeb 90/600 g/kg WP 

(SYS50579): Acute Toxicity to Oncorhynchus mykiss and Daphnia magna: Lab Project 

Number: SBGR.90.250: 4901. Unpublished study prepared by Shell Research Ltd. 34 p. 

43917217 Toy, R.; Gray, A. (1992) Dimethomorph: Acute Toxicity of Dimethomorph/Mancozeb 

75/667 g/kg WP (SYS50588 R) to Oncorhynchus mykiss, Daphnia magna and 

Selenastrum capricornutum: Lab Project Number: SBGR.92.177: 5640. Unpublished 

study prepared by Shell Research Ltd. 42 p. 

45507201 Mitchell, G.; Boeri, R.; Wyskiel, D. et al. (2001) Acute Toxicity of BAS 550 F (AC 

336379, Dimethomorph) to Bluegill Sunfish, Lepomis macrochirus Under Flow-Through 

Test Conditions: Lab Project Number: ECO-00-312. Unpublished study prepared by T.R. 

Wilbury Laboratories, Inc. 59 p. {OPPTS 850.1075} 

44418101 Mitchell, G.; Christensen, G.; Magazu, J. (1997) Acute Toxicity of AC 336379 

(Dimethomorph) to the Sheepshead Minnow (Cyprinodon variegatus) under FlowThrough Test Conditions: (Final Report): Lab Project Number: ECO-96-306: 1182-AC: 

954-95-144. Unpublished study prepared by T.R. Wilbury Labs, Inc.; and American 

Cyanamid Co. 108 p. {OPPTS 850.1075} 

850.1010 Aquatic Invertebrate Acute Toxicity, Freshwater 

MRID Citation Reference 

47700317 Zok, S. (2007) BAS 651 00 F - Determination of the Acute Effect on the Swimming 

Ability of the Water Flea Daphnia magna STRAUS. Project Number: 

2007/1053424/OCR, 2007/1053424, 50E0166/063176. Unpublished study prepared by 

BASF Aktiengesellschaft. 41 p. 

43917213 Ellgehausen, H. (1986) 48-Hour Acute Toxicity of CME 151 to Daphnia magna: (OECD 

Immobilization Test): Lab Project Number: 068128. Unpublished study prepared by R C 

C Umweltchemie AG. 21 p. 

43917215 Toy, R. (1991) CME 151/Mancozeb 90/600 g/kg WP (SYS50586): Acute Toxicity to 

Salmo Gairdneri and Daphnia magna: Lab Project Number: SBGR.90.159: 4467. 
Page 33 of 43 

Unpublished study prepared by Shell Research Ltd. 37 p. 

43917216 Toy, R.; Gray, A. (1991) Dimethomorph: CME 151/Mancozeb 90/600 g/kg WP 

(SYS50579): Acute Toxicity to Oncorhynchus mykiss and Daphnia magna: Lab Project 

Number: SBGR.90.250: 4901. Unpublished study prepared by Shell Research Ltd. 34 p. 

43917217 Toy, R.; Gray, A. (1992) Dimethomorph: Acute Toxicity of Dimethomorph/Mancozeb 

75/667 g/kg WP (SYS50588 R) to Oncorhynchus mykiss, Daphnia magna and 

Selenastrum capricornutum: Lab Project Number: SBGR.92.177: 5640. Unpublished 

study prepared by Shell Research Ltd. 42 p. 

45507202 Mitchell, G.; Boeri, R.; Wyskiel, D. et al. (2001) Acute Toxicity of BAS 550 F (AC 

336379, Dimethomorph) to Daphnia magna Under Static Test Conditions: Lab Project 

Number: ECO-00-314. Unpublished study prepared by T. R. Wilbury Laboratories, Inc. 

54 p. {OPPTS 850.1010} 

 

850.1035/850.1025 Aquatic Invertebrate Acute Toxicity, Estuarine/Marine 

MRID Citation Reference 

 

44418102 Mitchell, G.; Christensen, G.; Magazu, J. (1997) Effect of AC 336379 (Dimethomorph) 

on New Shell Growth in the Eastern Oyster (Crassostrea virginica) Under Flow-Through 

Test Conditions: (Final Report): Lab Project Number: ECO-96-305: 1181-AC: 954-96-

305. Unpublished study prepared by T. R. Wilbury Labs, Inc.; and American Cyanamid 

Co. 106 p. {OPPTS 850.1025} 

44418103 Mitchell, G.; Christensen, G.; Magazu, J. (1997) Acute Toxicity of AC 336379 

(Dimethomorph) to the Mysid (Mysidopsis bahia) Under Flow-Through Test Conditions: 

(Final Report): Lab Project Number: ECO-96-304: 1180-AC: 954-95-144. Unpublished 

study prepared by T.R. Wilbury Labs, Inc.; and American Cyanamid Co. 106 p. {OPPTS 

850.1035} 

850.1300 Aquatic Invertebrate Life Cycle, Freshwater 

MRID Citation Reference 

43917214 Memmert, U.; Knoch, E. (1996) Influence of Dimethomorph on Survival and 

Reproduction of Daphnia magna in a Semistatic Test (22 Days): (amended Report): 

Lab Project Number: 328410: 328421. Unpublished study prepared by R C C 

Umweltchemie GmbH. 47 p. 

43917219 Toy, R.; Gray, A. (1991) Dimethomorph: CME 151/Mancozeb 90/600 g/kg WP 

(SYS50579): Chronic Toxicity to Daphnia magna: Lab Project Number: SBGR.91.010: 

4698. Unpublished study prepared by Shell Research Ltd. 42 p. 

44418105 Mitchell, G.; Christensen, G.; Murrell, H. (1997) Chronic Toxicity of AC 336,379 

(Dimethomorph) Technical During the Complete Life-Cycle of Daphnia magna Under 

Flow-Through Test Conditions: Lab Project Number: ECO-96-275: 43364: 954-96-

275. Unpublished study prepared by ABC Labs, Inc.; and American Cyanamid Co. 245 

p. {OPPTS 850.1300} 
Page 34 of 43 

850.1400 Fish Early-Life Stage, Freshwater and Estuarine/Marine 

MRID Citation Reference 

44418104 Mitchell, G.; Christensen, G.; Rhodes, J. (1997) Toxicity of AC 336,379 

(Dimethomorph) Technical During the Early Life-Stages of Rainbow Trout 

(Oncorhynchus mykiss): (Final Report): Lab Project Number: ECO-96-274: 43365: 

954-96-274. Unpublished study prepared by ABC Labs, Inc.; and American Cyanamid 

Co. 217 p. {OPPTS 850.1400} 

45765501 Zok, S. (2002) BAS 550 F--Early Life-Stage Toxicity Test on the Fathead Minnow 

(Pimephales promelas): Final Report: Lab Project Number: 51F0271/015108: 

2002/1011268. Unpublished study prepared by BASF Aktiengesellschaft. 95 p. 

{OPPTS 850.1400} 

48326906 Hicks, S. (2010) BAS 550 F: Early Life-Stage Toxicity Test with the Sheepshead 

Minnow, Cyprinodon variegatus, Under Flow-Through Conditions. Project Number: 

2010/7012691, 65140, 375482. Unpublished study prepared by ABC Laboratories, Inc. 

94 p. 

850.1730 Aquatic org. accumulation (check Fate studies 165-5) 

MRID Citation Reference 

44996202 Zulalian, J. (1999) Dimethomorph (AC 336379): Uptake, Depuration, Bioconcentration 

and Metabolism of Carbon-14 Labeled AC 336379 in Bluegill Sunfish (Lepomis 

macrochirus) Under Flow-Through Conditions: Lab Project Number: MET 99-005: 

M98F379M01: 44560. Unpublished study prepared by American Cyanamid Co. 632 p. 

{OPPTS 850.1730} 

850.1770 Sediment Acute Toxicity, Freshwater Benthos 

MRID Citation Reference 

48326907 Wisk, J. (1998) Assessment of Potential Risk of Aquatic Sediment Degradate of 

Dimethomorph to Sediment-Dwelling Aquatic Invertebrates. Project Number: 

DK/570/002. Unpublished study prepared by BASF Agro Research. 8 p. 

850.4100 Terrestrial Plant Toxicity, Tier I and II (Seedling Emergence) 

MRID Citation Reference 

44283401 Chetram, R.; Christensen, G.; Goodman, V. et al. (1997) Nontarget Terrestrial Plant 

Phytotoxicity Studies Using a 9%/60% WP Co-formulation of AC 336379 

(Dimethomorph) and Mancozeb: (Final Report): Lab Project Number: 954-96-107: 954-

96-108: 954-96-149. Unpublished study prepared by ABC Laboratories California. 250 p. 

47700329 Porch, J.; Krueger, H.; Kendall, T.; et al. (2009) BAS 651 00 F: A Toxicity Test to 

Determine the Effects of the Test Substance on Seedling Emergence of Ten Species of 

Plants. Project Number: 2009/7004734/OCR, 2009/7004734, 147/241. Unpublished study 

prepared by Wildlife International, Ltd. 119 p. 
Page 35 of 43 

850.4150 Terrestrial Plant Toxicity, Tier 1 or Tier II (Vegetative Vigor) 

MRID Citation Reference 

47700328 Porch, J.; Krueger, H.; Kendall, T.; et al. (2009) BAS 651 00 F: A Toxicity Test to 

Determine the Effects of the Test Substance on Vegetative Vigor of Ten Species of 

Plants. Project Number: 2009/7004735/OCR, 2009/7004735, 147/242. Unpublished study 

prepared by Wildlife International, Ltd. 169 p. 

850.4400 Aquatic Plant Toxicity, Tiers 1 and II 

MRID Citation Reference 

45507203 

Junker, M. (2001) Effect of BAS 550 01 F on the Growth of Lemna gibba: Lab Project 

Number: 64718. Unpublished study prepared by BASF Aktiengesellschaft. 29 p. {OPPTS 

850.4400} 

850.5400 Algal Toxicity, Tiers 1 and II 

MRID Citation Reference 

47700315 Zok, S. (2008) BAS 651 00 F - Determination of the Inhibitory Effect on the Cell 

Multiplication of the Unicellular Green Algae Pseudokirchneriella subcapitata 

KORSHIKOV. Project Number: 2007/1056995/OCR, 2007/1056995, 60E0166/063177. 

Unpublished study prepared by BASF Aktiengesellschaft. 48 p. 

43917217 Toy, R.; Gray, A. (1992) Dimethomorph: Acute Toxicity of Dimethomorph/Mancozeb 

75/667 g/kg WP (SYS50588 R) to Oncorhynchus mykiss, Daphnia magna and 

Selenastrum capricornutum: Lab Project Number: SBGR.92.177: 5640. Unpublished 

study prepared by Shell Research Ltd. 42 p. 

43917222 Ellgehausen, H. (1987) Acute Toxicity of CME 151 to Scenedesmus subspicatus: (OECD 

Algae Growth Inhibition Test): Lab Project Number: 068141. Unpublished study 

prepared by R C C Umweltchemie AG. 22 p. 

44283402 Canez, V.; Christensen, G.; Hughes, J.; et al. (1997) Effects of a 9%/60% WP Coformulation of AC 336379 (Dimethomorph) and Mancozeb on the Growth of Navicula 

pelliculosa, Selenastrum capricornutum, Anabaena flos-aquae, Skeletonema costatum, 

and Lemna gibba: (Final Report): Lab Project Number: 954-96-113: 954-96-166: 954-96-

111. Unpublished study prepared by Carolina Ecotox. Inc. 457 p. 

45507204 Werner, D. (2001) BAS 550 01 F--Determination of the Inhibitory Effect on the Cell 

Multiplication of Unicellular Green Algae: Lab Project Number: 01/0274/60/1. 

Unpublished study prepared by BASF Aktiengesellschaft. 28 p. {OPPTS 850.5400} 

850.3020 Honey Bee Acute Contact Toxicity 

MRID Citation Reference 

47700318 Muether-Paul, J. (2006) Assessment of Side Effects of BAS 651 00 F to the Honey Bee, 

Apis mellifera L. in the Laboratory. Project Number: 2006/1012042/OCR, 2006/1012042, 

20061234/01/BLEU. Unpublished study prepared by Eurofins - GAB GmbH. 30 p. 
Page 36 of 43 

43917223 Harrison, E.; Hillaby, J. (1989) The Acute Topical and Oral Toxicity of CME 151 

(WL127294) to the Honey Bee, Apis mellifera L: Lab Project Number: SBGR.88.218: 

4014. Unpublished study prepared by Shell Research Ltd. 28 p. 

Non-Guideline Earthworm Toxicity 

MRID Citation Reference 

47700319 Vertesi, A. (2008) Acute Toxicity of BAS 651 00 F on Earthworms (Eisenia fetida) in 

Artificial Soil with 5% Peat (Including Amendment No. 1). Project Number: 

2008/7019535/OCR, 2008/7019535, 07/417/125G. Unpublished study prepared by LAB 

International Research Centre Hungary, Ltd. 36 p. 

47700320 Friedrich, S. (2007) Sublethal Toxicity of BAS 651 00 F to the Earthworm Eisenia fetida 

in Artificial Soil with 5% Peat. Project Number: 2007/1037735/OCR, 2007/1037735, 

250141. Unpublished study prepared by Biochem Agrar, Labor fuer Biologische und 

Chemische. 29 p. 

43917225 Ellgehausen, H. (1986) Acute Toxicity (LC50) Study of CME 151 to Earthworms: Lab 

Project Number: 068130. Unpublished study prepared by R C C Umweltchemie AG. 15 

p. 

Non-Guideline Study Selections 

MRID Citation Reference 

43917224 Harrison, E. (1990) The Toxicity of Dimethomorph to the Predatory Mite Phytoseiulus 

persimilis: Lab Project Number: SBGR.89.272. Unpublished study prepared by Shell 

Research Ltd. 27 p. 

47700326 Schulz, L. (2009) Effects of BAS 651 00 F on the Activity of Soil Microflora (Carbon 

Transformation Test) (Including Amendment No. 1). Project Number: 

2009/7003694/OCR, 2009/7003694, 250153. Unpublished study prepared by Biochem 

Agrar, Labor fuer Biologische und Chemische. 31 p. 

47700327 Schulz, L. (2009) Effects of BAS 651 00 F on the Activity of Soil Microflora (Nitrogen 

Transformation Test) (Including Amendment No. 1). Project Number: 

2009/7003695/OCR, 2009/7003695, 250105. Unpublished study prepared by Biochem 

Agrar, Labor fuer Biologische und Chemische. 33 p. 

45007307 Boczon, L. (1996) Eye Irritation Study in Albino Rabbits with AC 336,379 50 WP 

Formulation. Unpublished study prepared by American Cyanamid Company. 111 p. 

47700322 Sipos, K. (2009) Effect of BAS 651 00 F on the Predatory Mite (Typhlodromus pyri) in 

a Laboratory Trial (Including Amendment No. 1). Project Number: 

2009/7006311/OCR, 2009/7006311, 07/417/335RA. Unpublished study prepared by 

LAB Research, Ltd. 34 p. 

47700323 Sipos, K. (2007) Effect of BAS 651 00 F on the Parasitic Wasp (Aphidius rhopalosiphi) 

in a Laboratory Trial. Project Number: 2007/1035598/OCR, 2007/1035598, 

07/417/335FD. Unpublished study prepared by LAB International Research Centre 

Hungary, Ltd. 30 p. 

47700324 Sipos, K. (2008) Effect of BAS 651 00 F on the Parasitic Wasp (Aphidius rhopalosiphi) 

in an Extended Laboratory Trial (Including Amendment No. 1). Project Number: 

2008/7019536/OCR, 2008/7019536, 07/417/351FD. Unpublished study prepared by 

LAB Research, Ltd. 41 p. 
Page 37 of 43 

47700325 Roehlig, U. (2008) Effects of BAS 651 00 F on the Green Lacewing Chrysoperla 

carnea STEPH. Under Laboratory Conditions - Rate-Response-Test. Project Number: 

2008/1012070/OCR, 2008/1012070, 250114. Unpublished study prepared by Biochem 

Agrar, Labor fuer Biologische und Chemische. 29 p. 

47700321 Friedrich, S. (2007) Effects of BAS 651 00 F on the Reproduction of the Collembolans 

folsomia candida in Artificial Soil with 5% Peat. Project Number: 2007/1037736/OCR, 

2007/1037736. Unpublished study prepared by Biochem Agrar, Labor fuer Biologische 

und Chemische. 24 p. 

43917212 Memmert, U.; Knoch, E. (1996) Toxicity of Dimethomorph to Rainbow Trout 

(Oncorhynchus mykiss) in a Prolonged Flow-Through-Test (21 Days): (Amended 

Report): Lab Project Number: 328432: 328443. Unpublished study prepared by R C C 

Umweltchemie GmbH Co. KG. 50 p. 

43917218 Toy, R.; Gray, A. (1991) Dimethomorph: CME 151/Mancozeb 90/600 g/kg WP 

(SYS50579): Prolonged Toxicity to Rainbow Trout: Lab Project Number: 

SBGR.91.058: 4699. Unpublished study prepared by Shell Research Ltd. 29 p. 

268800 Dimethomorph Fate Chemistry Bibliography 

161-1 Hydrolysis 

MRID Citation Reference 

43917226 2069475 Ochsenbein, U. (1989) Hydrolysis Determination of (carbon 14)-Dimethomorph (CME 

151) at Different pH Values: Lab Project Number: 223830. Unpublished study prepared by 

R C C Umweltchemie AG. 71 p. 

161-2 Photodegradation-water 

MRID Citation Reference 

43917227 2069476 van Dijk, A. (1990) Photodegradation Study of (carbon 14)-Dimethomoprh (CME 151) in 

Water: Lab Project Number: 211421. Unpublished study prepared by R C C 

Umweltchemie AG. 74 p. 

161-3 Photodegradation-soil 

MRID Citation Reference 

43917228 2069477 van Dijk, A. (1989) Photodegradation Study of (carbon 14)-Dimethomorph (CME 151) 

on Soil: Lab Project Number: 211410. Unpublished study prepared by R C C 

Umweltchemie AG. 56 p. 

162-1 Aerobic soil metabolism 

MRID Citation Reference 

43917229 2069478 Schluter, H. (1990) (Chlorophenyl-(carbon 14))-Dimethomorph: Degradation in Soil 
Page 38 of 43 

 Under Aerobic Conditions: Lab Project Number: SHGR.90.003. Unpublished study 

prepared by Shell Forschung GmbH. 52 p. 

43917230 2069479 Edwards, V.; Standen, M. (1990) Dimethomorph (Morpholine-(carbon 14)): Degradation 

in Soil Under Aerobic Conditions: Lab Project Number: SBGR.90.002: 4043. 

Unpublished study prepared by Shell Research Ltd. 32 p. 

162-2 Anaerobic soil metabolism 

MRID Citation Reference 

43917231 2069480 Thiele, J. (1990) (Chlorophenyl-(carbon 14))-Dimethomorph: Degradation in Soil 

Under Anaerobic Conditions: Lab Project Number: SHGR.89.069: CUE 1/88. 

Unpublished study prepared by Shell Forschung GmbH. 62 p. 

43917232 2069481 Edwards, V.; Standen, M. (1990) Dimethomorph (Morpholine-(carbon 14)): 

Degradation in Soil Under Anaerobic Conditions: Lab Project Number: 

SBGR.89.215: 4043: 4044. Unpublished study prepared by Shell Research Ltd. 40 p. 

44780201 2069486 

2069494-memo 

2069495-memo 

Meyers, C. (1998) AC 336379 (Dimethomorph): Anaerobic Soil Metabolism: Lab 

Project Number: ENV 96-114: E-96-014. Unpublished study prepared by American 

Cyanamid Company. 240 p. 

48326903 2069483 Edwards, V.; Standen, M. (1990) Dimethomorph [Morpholine-Carbon 14)]: 

Degradation in Soil under Anaerobic Conditions. Project Number: SBGR/89/215, 

DK/123/050. Unpublished study prepared by Shell Research Ltd., London. 41 p. 

48326904 DER not 

located 

Theile, J. (1990) [Chlorophenyl-(Carbon 14)]-Dimethomorph: Degradation in Soil 

under Anaerobic Conditions. Project Number: SHGR/89/069, DK/123/049. 

Unpublished study prepared by Shell Forschung Gmbh. 63 p. 

162-3 Anaerobic aquatic metab. 

MRID Citation Reference 

43917233 2069482 Knoch, E. (1993) Dimethomorph Degradation and Metabolism in Aquatic Systems: 

Lab Project Number: 276805. Unpublished study prepared by R C C Umweltchemie 

GmbH & Co., KG. 91 p. 

162-4 Aerobic aquatic metab. 

MRID Citation Reference 

43917233 2069482 

2069493- 

summary 

Knoch, E. (1993) Dimethomorph Degradation and Metabolism in Aquatic Systems: 

Lab Project Number: 276805. Unpublished study prepared by R C C Umweltchemie 

GmbH & Co., KG. 91 p. 

48326905 DER not 

located 

Ebert, D. (2002) Degradation of BAS 550 F (Dimethomorph) in Water/Sediment - 

Systems under Aerobic Conditions. Project Number: 97149, 2002/1000201. 

Unpublished study prepared by BASF Aktiengesellschaft. 102 p. 

163-1 Leach/adsorp/desorption 
Page 39 of 43 

MRID Citation Reference 

43917234 2069483 Eichler, D. (1988) Soil Adsorption/Desorption Study with Dimethomorph (CME 151): 

Lab Project Number: CU 87/377A: 31/8/88. Unpublished study prepared by Shell 

Forschung GmbH. 30 p. 

43917235 2069484 Haas-Jobelius, M. (1991) (Chlorophenyl-(carbon 14)-Dimethomorph (CME 151) Soil 

Adsorption/Desorption: Lab Project Number: SHGR.90.011: CUE 90/8. Unpublished 

study prepared by Shell Forschung GmbH. 50 p. 

44780202 2069485 

2069487 

2069494-95 

memos 

An, D. (1998) Dimethomorph (AC 336379): Adsorption/Desorption on Soils: Lab 

Project Number: ENV 98-002: E-98-002. Unpublished study prepared by American 

Cyanamid Company. 77 p. 

164-1 Terrestrial field dissipation 

MRID Citation Reference 

43917236 2069493-not 

reviewed 

Thiele, J. (1990) Soil Dissipation of Dimethomorph (CME 151) Under Field 

Conditions I: Lab Project Number: SHGR.89.066: CU 88/516. Unpublished study 

prepared by Shell Forschung GmbH. 24 p. 

43917237 2069493-not 

reviewed 

Thiele, J. (1990) Soil Dissipation of Dimethomorph (CME 151) Under Field 

Conditions II: Lab Project Number: SHGR.89.068: CU 88/516. Unpublished study 

prepared by Shell Forschung GmbH. 24 p. 

43917238 2069493-not 

reviewed 

Thiele, J. (1991) Soil Dissipation of Dimethomorph (CME 151) Under Field 

Conditions III: Lab Project Number: SHGR.90.007: CUE 3/89. Unpublished study 

prepared by Shell Forschung GmbH. 25 p. 

43917239 2069493-not 

reviewed 

Thiele, J. (1991) Soil Dissipation of Dimethomorph (CME 151) Under Field 

Conditions V: Lab Project Number: SHGR.90.009: CU 90/6: FAMS 006-01. 

Unpublished study prepared by Shell Forschung GmbH. 45 p. 

43970304 2069493-not 

reviewed 

Thiele, J.; Buch, T. (1991) Soil Dissipation of Dimethomorph (CME 151) Under Field 

Conditions IV: Lab Project Number: SHGR.90.008: CUE 4/89. Unpublished study 

prepared by Shell Forschung GmbH. 47 p. 

44996201 2069488 Babbit, B.; Kleiner, A.; Lennon, G. (1999) Dissipation of Soil Residues of 

Dimethomorph: Lab Project Number: RES 99-073. 02: RES 99-081: RES 97-012. 

Unpublished study prepared by American Cyanamid Co. 593 p. 

165-5 Fish Bioaccumulation 

44996202 2069489 Zulalian, J. 1999. Dimethomorph (AC 336379): Uptake, depuration, bioconcentration and 

metabolism of carbon-14 labeled AC 336379 in bluegill sunfish (Lepomis macvochirus) 

under flow-through conditions. Report No.: MET 99-005. Unpublished study performed 

by American Cyanamid Company, Princeton, NJ (analytical phase); and ABC 

Laboratories, Inc., Columbia, MO (in-life phase); and submitted by American Cyanamid 

Company, Princeton, NJ. 

166-1 Ground water-small prospective 

MRID Citation Reference 
Page 40 of 43 

45721301 Inert Allen, R. (2002) (Inert Ingredient): Ground and Surface Water Exposure Concentrations 

Following Use of Foramsulfuron SC Herbicide in Turf: Lab Project Number: B003937. 

Unpublished study prepared by Aventis Environmental Science. 7 p. 

Non Guideline Selections 

47700326 

Not 

registered 

Mixture 

with 

119201 

Schulz, L. (2009) Effects of BAS 651 00 F on the Activity of Soil Microflora (Carbon 

Transformation Test) (Including Amendment No. 1). Project Number: 

2009/7003694/OCR, 2009/7003694, 250153. Unpublished study prepared by Biochem 

Agrar, Labor fuer Biologische und Chemische. 31 p. 

47700327 

Not 

registered 

Mixture 

with 

119201 

Schulz, L. (2009) Effects of BAS 651 00 F on the Activity of Soil Microflora (Nitrogen 

Transformation Test) (Including Amendment No. 1). Project Number: 

2009/7003695/OCR, 2009/7003695, 250105. Unpublished study prepared by Biochem 

Agrar, Labor fuer Biologische und Chemische. 33 p. 

47700330 

Not 

registered 

Mixture 

with 

119201 

Bitterlich; Kaltz, S. (2007) Evaluation of Physical and Chemical Properties According to 

Directive 94/37/EC (67/548/EC Annex V). Project Number: 2006/1035539/OCR, 

2006/1035539, SIK/NR/06/2896. Unpublished study prepared by BASF 

Aktiengesellschaft. 12 p. 

N.A. 2069491 

and 

2069493 Fate Data Summary 

N/A 2069490 Appendix 

 
Page 41 of 43 

Appendix C. SIP and STIR results 

Table C.1. SIP Inputs 

Parameter Value 

Chemical name Dimethomorph 

Solubility (in water at 25oC; mg/L) 18 

 

Mammalian LD50 (mg/kg-bw) 3600 

Mammalian test species laboratory rat 

Body weight (g) of "other" mammalian 

species 

 

Mammalian NOAEL (mg/kg-bw) 300 

Mammalian test species laboratory rat 

Body weight (g) of "other" mammalian 

species 

 

Avian LD50 (mg/kg-bw) 2000 

Avian test species northern bobwhite quail 

Body weight (g) of "other" avian species 

Mineau scaling factor 1.15 

 

Mallard NOAEC (mg/kg-diet) 800 

Bobwhite quail NOAEC (mg/kg-diet) 200 

NOAEC (mg/kg-diet) for other bird species 

Body weight (g) of other avian species 

NOAEC (mg/kg-diet) for 2nd other bird 

species 

Body weight (g) of 2nd other avian species 

 

Table C.2. Mammalian Results 

Parameter Acute Chronic 

Upper bound exposure (mg/kg-bw) 3.0960 3.0960 

Adjusted toxicity value (mg/kg-bw) 2768.9780 230.7482 

Ratio of exposure to toxicity 0.0011 0.0134 

Conclusion* 

Drinking water exposure 

alone is NOT a potential 

concern for mammals 

Drinking water exposure 

alone is NOT a potential 

concern for mammals 

 

Table C.3. Avian Results 

Parameter Acute Chronic 

Upper bound exposure (mg/kg-bw) 14.5800 14.5800 

Adjusted toxicity value (mg/kg-bw) 17800.0000 21.2597 

Ratio of exposure to acute toxicity 0.0008 0.6858 

Conclusion* 

Drinking water exposure 

alone is NOT a potential 

concern for birds 

Drinking water exposure 

alone is NOT a potential 

concern for birds 

 
Page 42 of 43 

*Conclusion is for drinking water exposure alone. This does not combine all routes of exposure. 

Therefore, when aggregated with other routes (i.e., diet, inhalation, dermal), pesticide exposure through 

drinking water may contribute to a total exposure that has potential for effects to non-target animals. 

Welcome to the EFED 

Screening Tool for Inhalation Risk 

This tool is designed to provide the risk assessor with a rapid method for determining the potential 

significance of the inhalation exposure route to birds and mammals in a risk assessment. 

 

Input 

Application and Chemical Information 

Enter Chemical Name Dimethomorph 

Enter Chemical Use fungicide 

Is the Application a Spray? (enter y or n) y 

If Spray What Type (enter ground or air) ground 

Enter Chemical Molecular Weight (g/mole) 387.86 

Enter Chemical Vapor Pressure (mmHg) 7.30E-09 

Enter Application Rate (lb a.i./acre) 0.2 

 

Toxicity Properties 

Bird 

Enter Lowest Bird Oral LD50 (mg/kg bw) 2000 

Enter Mineau Scaling Factor 1.15 

Enter Tested Bird Weight (kg) 0.178 

Mammal 

Enter Lowest Rat Oral LD50 (mg/kg bw) 3600 

Enter Lowest Rat Inhalation LC50 (mg/L) 4.24 

Duration of Rat Inhalation Study (hrs) 4 

Enter Rat Weight (kg) 0.35 

 

Output 

Results Avian (0.020 kg ) 

Maximum Vapor Concentration in Air at Saturation 

(mg/m3) 1.52E-04 

Maximum 1-hour Vapor Inhalation Dose (mg/kg) 1.92E-05 

Adjusted Inhalation LD50 1.31E+01 

Ratio of Vapor Dose to Adjusted Inhalation LD50 1.46E-06 Exposure not Likely Significant 

Maximum Post-treatment Spray Inhalation Dose (mg/kg) 2.11E-02 

Ratio of Droplet Inhalation Dose to Adjusted Inhalation 

LD50 1.61E-03 Exposure not Likely Significant 

 
Page 43 of 43 

Results Mammalian (0.015 kg ) 

Maximum Vapor Concentration in Air at Saturation 

(mg/m3) 1.52E-04 

Maximum 1-hour Vapor Inhalation Dose (mg/kg) 2.41E-05 

Adjusted Inhalation LD50 2.52E+02 

Ratio of Vapor Dose to Adjusted Inhalation LD50 9.54E-08 Exposure not Likely Significant 

Maximum Post-treatment Spray Inhalation Dose (mg/kg) 2.66E-02 

Ratio of Droplet Inhalation Dose to Adjusted Inhalation 

LD50 1.05E-04 Exposure not Likely Significant