<PAGE>   1
                                                                   EXHIBIT 10.29


                                CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
                                THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH
                                THE SECURITIES AND EXCHANGE COMMISSION PURSUANT
                                TO RULE 24b-2 OF THE SECURITIES EXCHANGE ACT OF
                                1934, AS AMENDED.



                               AMENDMENT NO. 4 TO
                        THE LICENSE AND SUPPLY AGREEMENT
                         BETWEEN COR THERAPEUTICS, INC.
                                       AND
                                  SOLVAY, S. A.



        THIS AMENDMENT NO. 4 to the License and Supply Agreement (the
"Amendment") is entered into between COR Therapeutics, Inc. ("COR"), a Delaware
corporation, with its principal offices at 256 East Grand Avenue, South San
Francisco, California, USA 94080, and Solvay, Societe Anonyme ("Solvay"), a
Belgian corporation, with its principal offices at 33, rue du Prince Albert,
1050 Bruxelles, Belgium, each on behalf of itself and its Affiliates. This
Amendment shall be effective on April 1, 1997 (the "Amendment Effective Date").

RECITALS

        WHEREAS, COR and Solvay entered into a License and Supply Agreement
dated 27 July 1994 (the "License and Supply Agreement") and a Long Term Supply
Agreement dated 28 September 1995 (the "Long Term Supply Agreement") to provide
for the manufacture of a bulk peptide product and for the supply of that product
to COR for commercial and clinical use; and

        WHEREAS, Solvay has agreed that COR may utilize [*] on certain terms;
and

        WHEREAS, the Parties desire to clarify certain matters related to the
transfer of technology and communications between the Parties.

        NOW THEREFORE, in consideration of the foregoing and the covenants and
promises contained in this Amendment, COR and Solvay hereby amend the License
and Supply Agreement as follows.

        In this Amendment, capitalized terms shall have the meanings provided
herein or otherwise provided by the License and Supply Agreement. Headings are
for the convenience of the Parties only, and shall not be of any force or
substance.

1.      Section 1.7 shall be deleted and replaced with the following:


                                       1.


                                          CONFIDENTIAL TREATMENT REQUESTED = [*]


<PAGE>   2


        1.7 "INTEGRILIN" shall refer to a specific peptide designated by COR and
known as Integrilin(TM), which same peptide was known previously as
"Integrelin", the chemical structure of which is known to Solvay because of the
prior business relationship between COR and Solvay. Any references herein to
Integrelin shall be deemed to refer to Integrilin.

2.      Section 1.9 shall be deleted and replaced with the following:

        1.9 "NET BULK SALES" shall mean as to each calendar quarter the gross
invoiced sales price charged for all Bulk Products sold to COR [*] or a
Secondary Source, after deducting the following items paid by COR during such
calendar quarter with respect to sales of Bulk Product hereunder regardless of
the calendar quarter in which such sales were made, provided and to the extent
that such items are incurred, and are included in the price charged:

                (a)     trade, quantity and case discounts or rebates;

                (b)     credits or allowances given or made for rejection or
                        return of previously sold Bulk Product;

                (c)     any tax or government charge (other than an income tax)
                        levied on the sale, transportation or delivery of Bulk
                        Product and borne by the seller thereof; and

                (d)     any charges for freight or insurance in a CIF sale.

3.      Section 1.13 shall be inserted after Section 1.12 as follows:

        1.13 "STEP ONE INTERMEDIATES" shall refer to those Bulk Product
Intermediates, [*] which exist upon completion of the manufacture of Bulk
Product through a certain step (designated by the Parties as "Step One").

4.      Section 2.2 shall be deleted and replaced with the following:

        2.2 Secondary Supply. COR shall have the right to establish a Secondary
Source for the manufacture of Bulk Product by the Licensed Process for COR. The
Secondary Source shall be [*] COR and Solvay agree that [*] would be acceptable
as the Secondary Source. COR will notify Solvay of the establishment of the
Secondary Source. In the event COR terminates a supply arrangement with a
Secondary Source, COR may establish an alternate Secondary 


                                       2.


                                          CONFIDENTIAL TREATMENT REQUESTED = [*]
<PAGE>   3


Source. COR shall notify Solvay within [*] of such a termination of supply
arrangements with a Secondary Source. Further, after the Secondary Source is
established, COR may use [*]. COR's future requirements for Bulk Product [*] COR
wants to entertain certain [*]. Therefore, after the Secondary Source is
established, COR shall [*] purchase from Solvay [*] of its total, worldwide
requirements for Bulk Product on a year-to-year basis (to the extent that such
[*] does not exceed the manufacturing capacity planned by Solvay to produce Bulk
Product) for the time period during which royalties are payable under this
Agreement. For purposes of the preceding sentence, such planned capacity shall
be determined for a particular calendar year X on [*]. Notwithstanding the above
however, COR may purchase from such Secondary Source [*] of its requirements in
the event of any breach or default of Solvay of any supply arrangement between
COR and Solvay, for so long as the breach or default remains uncured. [*] COR
may establish an additional, "Back-up" Secondary Source for the manufacture of
Bulk Product. In the event that COR wishes to establish [*] then COR and Solvay
shall negotiate in good faith, before [*].

5.      Section 3.1 shall be deleted and replaced with the following:

        3.1     Grant by Solvay. Solvay hereby grants to COR under the Solvay
Patents and Solvay Know-how an irrevocable (subject to Section 5.2), sole --
with Solvay and Solvay Affiliates -- worldwide license, with right to sublicense
to the Secondary Source and the Back-up Secondary Source, to develop, use for
regulatory or legal purposes, sell, have sold, and either manufacture if COR is
the Secondary Source and/or Back-up Secondary Source, or have manufactured by
the Secondary Source and/or Back-up Secondary Source [*] Integrilin and products
containing Integrilin produced practicing the Solvay Know-how or the Licensed
Process. In addition, Solvay hereby grants to COR the right, within the
foregoing license, to [*] to have Bulk Product manufactured by [*] for COR
produced by practicing the [*] Solvay Know-how or the Licensed Process, [*]. No
other rights than those expressly provided in this Agreement, the Long Term
Supply Agreement, and the Supply Agreement are granted by Solvay to COR or any
Secondary Source by implication or otherwise. COR [*]. Any rights sublicensed to
the Secondary Source or Back-up Secondary Source, pursuant to this Section 3.1
shall not be further transferred without the prior written consent of Solvay.
For the purpose of this Section 3.1, "sole" license shall mean that Solvay shall
not grant to any third party any right during the 



                                       3.


                                          CONFIDENTIAL TREATMENT REQUESTED = [*]
<PAGE>   4


term of this Agreement under the Solvay Patents and Solvay Know-how to
manufacture bulk peptide products containing Integrilin or to use or sell Bulk
Products manufactured thereby.

6.      Section 3.3 shall be deleted and replaced with the following:

        3.3     Process Improvements The Parties acknowledge that Solvay or COR
may develop or acquire improvements to the manufacturing materials, equipment,
procedure, Solvay Know-how or Licensed Process in the course of fulfilling its
obligations under this Agreement and the Supply Agreement. Solvay agrees to
obtain COR's consent prior to implementing such improvements, or any changes in
the Licensed Process or in any [*]. Any such improvements developed or acquired
by Solvay which are used commercially by Solvay or [*] and/or the Secondary
Source and/or Back-up Secondary Source for making bulk peptide products
containing Integrilin shall be deemed to be within the definition of Licensed
Process or Solvay Know-how as licensed in Section 3.1.

        Except as provided below, COR hereby agrees to use [*] and/or to
establish a Secondary Source (and/or Back-up Secondary Source) only if it agrees
to grant back to COR a non-exclusive, worldwide, royalty-free license,
sublicenseable by COR to entities entitled to practice the Licensed Process, to
use any improvements to the manufacturing materials, equipment, procedure,
Solvay Know-how or the Licensed Process related to this Agreement which are
developed or acquired by [*] or such Secondary Source, to develop, use, sell,
have sold, [*] or have manufactured by [*] and/or the Secondary Source (and/or
Back-up Secondary Source) [*] of this Agreement, Integrilin and products
containing Integrilin.

        However, for [*] the Secondary Source established by COR pursuant to
Section 2.2 of this Agreement, any sublicense to [*] those improvements which
are developed or acquired by Solvay upon or after [*] and whose use in the
Licensed Process would have a significant impact on the economics of the
practice of the Licensed Process or on the quality of the products produced
thereby, and such improvements [*].

        COR hereby agrees to sublicense the rights granted to it pursuant to
this Section 3.3 by [*] or a Secondary Source (and/or Back-up Secondary Source)
to Solvay, for use by Solvay during any time period wherein Solvay is supplying
COR with Bulk Product, pursuant to the terms of any supply arrangement between
COR and Solvay. COR agrees that it will use any such [*] or Secondary Source
improvements to manufacture Bulk Product [*] is the Secondary 



                                       4.


                                          CONFIDENTIAL TREATMENT REQUESTED = [*]
<PAGE>   5


Source, [*] COR [*] or Secondary Source improvements to manufacture Bulk Product
[*] Secondary Source when COR [*].

        For purposes of this Section 3.3, COR, Solvay, [*] and any Secondary
Source shall exchange rights to the improvements specified in this Section 3.3
which are developed or acquired by any of them during the time period between
the Effective Date and [*] at which time COR and Solvay agree to consider in
good faith, in consultation with [*] or any Secondary Source, whether or not the
exchange of improvements should be continued [*].

        In the event that COR [*], COR hereby agrees to grant to Solvay a
worldwide, royalty-free license, without right to sublicense, to use any
improvements to the manufacturing materials, equipment, procedure, Solvay
Know-how or the Licensed Process related to this Agreement which are owned or
developed by COR, to develop, manufacture, have made, use, sell and have sold
Integrilin and products containing Integrilin, according to the terms of this
Agreement, and for use by Solvay during any time period wherein Solvay is
supplying COR with Bulk Product, pursuant to the terms of any supply arrangement
between COR and Solvay.

        In the event that, despite good faith negotiations, a potential
Secondary Source with whom COR desires to contract is unable or refuses to grant
rights to its improvements to COR for further sublicense, then COR agrees that
any [*] or [*] by Solvay upon or after the establishment of that Secondary
Source shall [*] that Secondary Source, to be [*].

7.      Section 3.5 shall be deleted and replaced with the following:

        3.5     Technology Transfer to the Secondary Source. Promptly upon the
notification by COR to Solvay of the planned commencement of Bulk Product
manufacture by [*] for COR, or of the establishment of the Secondary Source or
the Back-up Secondary Source pursuant to Sections 2.2, 3.3 and 3.5 of this
Agreement, and updated at least quarterly, Solvay shall provide to the Secondary
Source, and to [*] if applicable, in a written form, [*] Solvay Know-how useful
for the manufacture of Bulk Product, including by way of example, [*] and any
documents which result from inspection by governmental agencies [*]. Solvay
shall disclose [*]. During the term of this Agreement, Solvay shall continue to
provide such technical assistance and access to information as may be useful for
[*] and/or the Secondary Source to manufacture Bulk Product by the Licensed
Process and to obtain appropriate regulatory approvals for the sale of products
containing Integrilin.



                                       5.


                                          CONFIDENTIAL TREATMENT REQUESTED = [*]
<PAGE>   6

        COR shall require [*] and the Secondary Source to agree that such Solvay
Know-how shall be distributed by [*] and/or the Secondary Source only to those
employees designated by [*] and/or the Secondary Source as having a need to know
such information, and who sign personal obligations of confidentiality with
Solvay with respect to Solvay Confidential Information. COR shall require [*]
and the Secondary Source to further agree to guarantee such personal obligations
of confidentiality made by its employees, respectively.

8.      Section 3.7 shall be inserted after Section 3.6 as follows:

        3.7 TECHNOLOGY TRANSFER AGENTS. Solvay agrees that COR may designate [*]
Technology Transfer Agents ("TTAs"). The mission of the TTAs shall be to
participate in the technology transfer team appointed to transfer the Solvay
Know-How to [*] [*] or a Secondary Source established pursuant to Section 2.2 of
this Agreement (the "Mission"). The Mission shall terminate on the earlier of
either the production under appropriate regulatory approvals related to
manufacturing by [*] and the Secondary Source of an aggregate amount of [*] of
Bulk Product for COR [*] or [*] of the supply, to [*] or to the Secondary Source
pursuant to Section 3.5 of this Agreement, of an initial disclosure package in a
written form which would include:

        [*]

        In the event that COR entrusts its Secondary Source, [*] with the
manufacture for COR of [*] the Mission shall be reactivated and shall terminate
again on the earlier of either the production under appropriate regulatory
approvals related to manufacturing by [*] of an aggregate amount of [*] of Bulk
Product for COR [*] or [*] of the supply in a written form of the initial
disclosure package described above - to [*] pursuant to Section 3.5 of this
Agreement.

        In the event that an alternate Secondary Source is established pursuant
to Section 2.2 of this Agreement, the Mission shall be reactivated and shall
terminate again on the earlier of either the production under appropriate
regulatory approvals related to manufacturing by such Secondary Source of an
aggregate amount of [*] of Bulk Product for COR [*] or [*] of the supply in a
written form of the initial disclosure package described above to such Secondary
Source pursuant to Section 3.5 of this Agreement.

        SOLVAY shall disclose promptly to the TTAs all information sufficient to
enable them to complete the Mission. Each TTA will be under confidentiality
obligations to SOLVAY in accordance with the Confidentiality Agreement given in
Exhibit E. The persons utilized as



                                       6.


                                          CONFIDENTIAL TREATMENT REQUESTED = [*]
<PAGE>   7

TTAs may be changed by COR with the prior written approval of Solvay, such
approval not to be unreasonably delayed or withheld.

9.      Section 4.9 shall be deleted and replaced with the following:

        4.9     Expenses for Training and Technology Transfer. COR shall pay to
Solvay, as compensation for technical assistance to COR, [*] or the Secondary
Source in the transfer of information including the Solvay Know-how and the
Licensed Process, and for training to personnel of [*] or the Secondary Source
[*] the amount of [*] any Solvay employee is providing such technical assistance
or training. From the [*] this amount shall be [*] for the [*]. COR shall also
bear all actually incurred [*] for Solvay personnel working for the benefit of
COR or [*] or the Secondary Source [*] upon invoice, with supporting
documentation, from Solvay.

10.     Section 6.7 shall be deleted and replaced with the following:

        6.7     Performance by Secondary Source. COR shall remain responsible
and be guarantor of the performance by [*] or the Secondary Source under this
Agreement and the Supply Agreement and shall cause [*] or the Secondary Source
to comply with the provisions of this Agreement and the Supply Agreement in
connection with such performance.

11.     Section 8.2 shall be deleted and replaced with the following:

        8.2     Authorized Disclosure. Each Party may disclose Confidential
Information hereunder to the extent such disclosure is reasonably necessary for
prosecuting or defending litigation, complying with applicable governmental
regulations or conducting preclinical or clinical trials, provided that if a
Party is required by law or regulation to make any such disclosure of the other
Party's Confidential Information it will, except where impracticable for
necessary disclosures, for example in the event of medical emergency, give
reasonable advance notice to the other Party of such disclosure requirement and
will use its reasonable efforts to secure confidential treatment of such
Confidential Information required to be disclosed. In addition, COR shall be
entitled to disclose, under a binder of confidentiality containing provisions as
protective as those of this Section 8.0, Solvay Confidential Information to [*]
or any Secondary Source permitted under Sections 2.2 and 3.0 of this Agreement.
Nothing in this



                                       7.


                                          CONFIDENTIAL TREATMENT REQUESTED = [*]
<PAGE>   8


Section 8.0 shall restrict any Party from using for any purpose any information
developed by it during the course of this Agreement. Neither Party shall
disclose Confidential Information of the other Party in any patent filings
without the prior written consent of the disclosing Party.

12.     Section 8.5 shall be deleted and replaced with the following:

        8.5     Confidentiality and Limitation on Use COR agrees, and shall
require [*] and the Secondary Source to agree, to not disclose Solvay Know-how
to any third party and not to use Solvay Know-how for any purpose other than the
production of Bulk Product, except for necessary disclosures to governmental
agencies such as the U.S. Food and Drug Agency and its equivalents, according to
the provisions of Section 8.0. COR shall require [*] and the Secondary Source to
sign a three-way confidentiality agreement (with COR and Solvay) in the form of
Exhibit D or in a form substantially similar to that of Exhibit D hereto but
having changes agreed to by COR and Solvay.

13.     Except as otherwise amended herein, the License and Supply Agreement
shall remain in full force and effect.



                                       8.


                                          CONFIDENTIAL TREATMENT REQUESTED = [*]

<PAGE>   9

        IN WITNESS WHEREOF, the Parties hereto have executed this Amendment to
be effective on the date set forth above.



COR THERAPEUTICS, INC.                      SOLVAY, S.A.


By:                                         By:
   --------------------------------            --------------------------------


Title:                                      Title:
      -----------------------------               -----------------------------



Exhibit E:  Technology Transfer Agent Confidentiality Agreement



                                       9.


                                          CONFIDENTIAL TREATMENT REQUESTED = [*]

<PAGE>   10

                                CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN
                                THIS DOCUMENT, MARKED BY BRACKETS, IS FILED WITH
                                THE SECURITIES AND EXCHANGE COMMISSION PURSUANT
                                TO RULE 24b-2 OF THE SECURITIES EXCHANGE ACT OF
                                1934, AS AMENDED.



                            CONFIDENTIALITY AGREEMENT


                  This Agreement is entered into effective as July 16, 1996
                  among:

                  SOLVAY, Societe Anonyme ("SOLVAY"), a Belgian corporation,
                  with its principal offices at 33, rue du Prince Albert, 1050
                  Brussels, Belgium, on behalf of itself and its Affiliates; and

                  COR Therapeutics, Inc. ("COR"), a Delaware corporation, with
                  its principal offices at 256 East Grand Avenue, South San
                  Francisco, California 94080, USA, on behalf of itself and its
                  Affiliates; and

                  [*] ("RECIPIENT"), a designee of COR with an address at [*]
                  USA.



                  WITNESSETH:

                  WHEREAS, COR owns certain patent rights, trademarks and
                  know-how relating to a product called INTEGRILIN(TM),

                  WHEREAS, SOLVAY has developed a unique and valuable patented
                  and proprietary process useful for the manufacture of
                  peptides, and is practising the said process for the
                  manufacture of bulk peptide products containing INTEGRILIN(TM)
                  sold to COR pursuant to several Agreements entered into
                  between SOLVAY and COR,

                  WHEREAS, SOLVAY has agreed to disclose confidential
                  information relating to its process to RECIPIENT, who has been
                  duly appointed by COR to participate in technology transfer
                  team in charge of the transfer of SOLVAY's technology to COR's
                  Secondary Source of supply of INTEGRILIN(TM) and to [*] the
                  production of bulk peptide products containing INTEGRILIN(TM)
                  for the account of SOLVAY.

                  NOW, THEREFORE, in consideration of the foregoing and the
                  mutual promises contained herein, the parties agree as
                  follows:

                  1.0. CERTAIN DEFINITIONS

                  For the purposes of this Agreement, the following terms shall
                  have the following meanings:



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                  1.1. "Affiliates" shall mean any entity or person which
                  controls, is controlled by or is under common control with
                  either Party. For purposes of this section 1.1., "control"
                  shall mean:

                  a) in the case of corporate entities, the direct or indirect
                  ownership of at least one-half of the stock or participating
                  shares entitled to vote for the election of directors, and

                  b) in the case of a partnership, the power to direct the
                  management and policies of such partnership.

                  Without limitation on the foregoing and for purposes of this
                  Agreement, PEPTISYNTHA & Cie, Societe en Nom Collectif
                  ("PEPTISYNTHA"), which is a fully owned subsidiary of SOLVAY
                  and an entity existing under the laws of Belgium and having
                  its principal offices at 310, rue de Ransbeek, 1120 Brussels,
                  Belgium, is deemed an Affiliate of SOLVAY.

                  1.2.     "Agreement Purpose" shall mean the participation of
                           RECIPIENT in the technology transfer team appointed
                           to Transfer SOLVAY's technology to COR's Secondary
                           Source of supply and [*]

                  1.3      "SOLVAY Confidential Information" shall mean any or
                           all confidential information relating to the process
                           developed by SOLVAY for the manufacture of bulk
                           peptide products containing INTEGRILIN(TM).

                  1.4.     "Effective Date" shall mean 07/16, 1996.

                  1.5.     "INTEGRILIN(TM)" shall mean a specific peptide
                           designated by COR and known as INTEGRILIN(TM), the
                           chemical structure of which is known to the Parties
                           pursuant to the terms of separate agreements entered
                           into with COR.

                  1.6.     "Party" shall mean SOLVAY, COR or RECIPIENT.

                  2.0.     DISCLOSURE OF SOLVAY CONFIDENTIAL INFORMATION

                  2.1.     SOLVAY shall disclose to RECIPIENT SOLVAY
                           Confidential Information sufficient to enable
                           RECIPIENT to fulfil the Agreement Purpose.

                  2.2      SOLVAY Confidential Information disclosed under
                           paragraph 2.1 hereabove may be disclosed in tangible
                           form, such as in writing and marked "Confidential",
                           or provided



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                  orally. SOLVAY confidential Information must be indicated to
                  be confidential at the time of its first disclosure to
                  RECIPIENT.

         3.0.     CONFIDENTIALITY AND EXCEPTIONS

         3.1.     RECIPIENT hereby agrees, regarding SOLVAY Confidential
                  Information, that he/she shall:

                  (a) make no use of said information, except for the Agreement
                  Purpose;

                  (b) not disclose said information to any party or person other
                  than a possible second person appointed by COR to fulfil the
                  Agreement Purpose and who shall have signed a confidentiality
                  agreement similar to this Agreement;

                  (c) not disclose said information to COR;

                  (d) not disclose to any party or person either the existence
                  of this Agreement or its underlying discussions except for the
                  Agreement Purpose;

                  (e) take the same steps to protect said information as he/she
                  takes to protect the proprietary and confidential information
                  of COR.

         3.2.     The obligations under paragraph 3.1 hereabove shall not,
                  however, apply to any SOLVAY Confidential Information which:

                  (a) RECIPIENT can prove is at the time of disclosure or
                  thereafter becomes public knowledge through no fault or
                  negligence of RECIPIENT, or

                  (b) RECIPIENT can prove was known to him/her, prior to the
                  receipt of such Confidential Information from SOLVAY, or

                  (c) is lawfully obtained by RECIPIENT from any party not bound
                  by a secrecy obligation towards SOLVAY relating to the
                  Confidential Information.

         For the purposes of this paragraph 3.2, information shall not be deemed
         to be public knowledge or known on the ground only that:




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                  (i) the general principle is public knowledge or known to
                  RECIPIENT if the particular practice is not itself public
                  knowledge or so known, or

                  (ii) it constitutes a combination of or is drawn from
                  information which is public knowledge or known to RECIPIENT
                  unless the combination itself and its principle and mode of
                  operation is also public knowledge or known to the RECIPIENT.

                  4.0. DOCUMENTS DELIVERY OR DESTRUCTION

                  Upon the written request of SOLVAY, RECIPIENT undertakes to
                  promptly deliver it, or destroy if so instructed by it, all
                  documents furnished by SOLVAY to RECIPIENT and constituting
                  Confidential Information, as well as all copies thereof which
                  might be in his/her possession.

                  5.0. NO IMPLIED LICENSE

                  Nothing in this Agreement shall be construed as to grant
                  RECIPIENT any title or right or license to own or use at any
                  time the SOLVAY Confidential Information, except as expressly
                  set forth herein.

                  6.0. COR'S RESPONSIBILITY

                  COR shall guarantee the performance of this Agreement by
                  RECIPIENT.

                  7.0. TERM

                  This Agreement shall become effective on the Effective Date
                  and shall remain in effect for six (6) months. The provisions
                  of Article 3 shall however survive until [*].

                  8.0. GENERAL PROVISIONS

                  8.1. Notices

                  All notices and demands required or permitted to be given or
                  made pursuant to this Agreement shall be in writing and shall
                  be deemed given if delivered personally or by given facsimile
                  transmission (receipt verified), telexed, mailed by registered
                  or certified mail (return receipt requested), postage prepaid,
                  or sent by express courier service, properly addressed to the
                  address of the Party to be notified as shown below:



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                  If to SOLVAY:

                  SOLVAY S.A.
                  DCR-LC
                  310, rue de Ransbeek
                  B - 1120 Brussels, Belgium

                  Attention  General Manager Research and Development

                  If to COR:

                  President, COR Therapeutics, Inc.
                  256 East Grand Avenue
                  South San Francisco, California 94080, USA

                  If to RECIPIENT:

                  [*]

                  or to such other address as to which any Party may notify the
                  others. Any notice sent by facsimile transmission or telex
                  shall be followed within twenty-four (24) hours by a signed
                  notice sent by first class mail, postage prepaid.

                  8.2. Assignment and Delegation

                  RECIPIENT may not assign his/her rights and/or delegate
                  his/her obligations under this Agreement to any third party
                  without the prior consent of SOLVAY and COR.

                  8.3. Amendment

                  No amendment or modification of the terms of this Agreement
                  shall be binding on any Party unless reduced to writing and
                  signed by the respective authorised officers of SOLVAY and COR
                  and by RECIPIENT.

                  8.4. Publicity

                  The Parties agree that, except as may otherwise be required by
                  applicable laws, regulations, rules or orders, no information
                  concerning this Agreement and the transactions contemplated
                  herein shall be made public by any Party without the prior
                  written consent of the others.

                  8.5. Waiver



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                  Failure of any Party to insist upon strict observance of or
                  compliance with any of the terms of this Agreement in one or
                  more instances shall not be deemed to be a waiver of its
                  rights to insist upon such observance or compliance with the
                  other terms hereof, at that point in time or in the future.

                  8.6. Counterparts

                  This Agreement may be executed in multiple counterparts, each
                  of which shall be an original, but all of which shall
                  constitute but one agreement.

                  8.7 Governing Law

                  This Agreement shall be governed by the laws of England.
                  SOLVAY, COR and RECIPIENT consent to the exclusive
                  jurisdiction and venue of the Courts of England.

                  IN WITNESS THEREOF, the parties hereto have executed this
                  Agreement, in three original copies.


SOLVAY S.A.                                 COR THERAPEUTICS, INC.




By:                                         By:
   --------------------------------            --------------------------------


Title:                                      Title:
      -----------------------------               -----------------------------



                                    RECIPIENT

                                       [*]







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