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|EXHIBIT 32.2
CERTIFICATION PURSUANT TO18 U.S.C.§1350,AS ADOPTED PURSUANT TOSECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
In connection with the Quarterly Report of Osteotech, Inc. (the Company) on Form 10-Q for
the quarter ended March 31, 2005 as filed with the Securities and Exchange Commission on the date
hereof (the Report), I, Michael J. Jeffries, Chief Financial Officer of the Company,
certify, pursuant to 18 U.S.C.§1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley
Act of 2002, that to my knowledge:
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| | (1) The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange

Act of 1934; and                               
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| | (2) The information contained in the Report fairly presents, in all material respects, the financial condition

and results of operations of the Company.
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| | /S/Michael J. Jeffries                                                                     
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| | Michael J. Jeffries
  Chief Financial Officer and
  Chief Accounting Officer
  May 10, 2005

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