**Certification        Pursuant to Section 13a-14 of the Securities Exchange Act of 1934        of**

**Thomas        L. Wegman**

**(President,        Principal Executive Officer and Principal Financial        Officer)**

|   | 1. | I                  have reviewed this Form 10-QSB for the quarterly period ended September                  30, 2006 (the                  “report”) of BioSpecifics Technologies Corp.                  (“registrant”); |
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|   | 2. | Based                  on my knowledge, the report does not contain any untrue statement                  of a                  material fact or omit to state a material fact necessary to make                  the                  statements made, in light of the circumstances under which such                  statements                  were made, not misleading with respect to the period covered by                  this                  report; |
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|   | 3. | Based                  on my knowledge, the financial statements, and other financial                  information                  included in this report, fairly present in all material respects                  the                  financial condition, results of operations and cash flows of the                  registrant as of, and for, the periods presented in this                  report; |
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|   | 4. | The                  small business issuer’s other certifying officers and I are responsible                  for establishing and maintaining disclosure controls and procedures                  (as                  defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal                  control over financial reporting (as defined in Exchange Act Rules                  13a-15(f) and 15d-15(f)) for the small business issuer and                  have: |
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|   | (a) | Designed                  such disclosure controls and procedures, or caused such disclosure                  controls and procedures to be designed under our supervision, to                  ensure                  that material information relating to the registrant, including                  its                  consolidated subsidiaries, is made known to us by others within                  those                  entities, particularly during the period in which this report is                  being                  prepared; |
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|   | (b) | Evaluated                  the effectiveness of the registrant’s disclosure controls and procedures                  and presented in this report our conclusions about the effectiveness                  of                  the disclosure controls and procedures, as of the end of the period                  covered by this report based on such evaluation;                  and |
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|   | (c) | Disclosed                  in this report any change in the registrant’s internal control over                  financial reporting that occurred during the registrant’s most recent                  fiscal quarter (the registrant’s fourth fiscal quarter in the case of an                  annual report) that has materially affected, or is reasonably likely                  to                  materially affect, the registrant’s internal control over financial                  reporting; and |
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|   | 5. | The                  small business issuer’s other certifying officers and I have disclosed,                  based on our most recent evaluation of internal control over                  financial reporting, to the registrant’s auditors and to the audit                  committee of the registrant’s board of directors (or persons performing                  the equivalent functions): |
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