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Exhibit 31

CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER AND PRINCIPAL
FINANCIAL OFFICERPURSUANT TO RULES 13a-14(a) AND 15d-14(a) OFTHE SECURITIES EXCHANGE ACT OF 1934

I, Thomas L. Wegman, certify that:

|1. | I have reviewed this report on Form 10-Q for the quarterly
      period ended March 31, 2011 of BioSpecifics Technologies Corp.;                                                                                                                                                                                                                             
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|2. | Based on my knowledge, the report does not contain any
      untrue statement of a material fact or omit to state a material fact
      necessary to make the statements made, in light of the circumstances under
      which such statements were made, not misleading with respect to the period
      covered by this report;                            
|   |                                                                                                                                                                                                                                                                                                                                                              
|3. | Based on my knowledge, the financial statements, and other
      financial information included in this report, fairly present in all
      material respects the financial condition, results of operations and cash
      flows of the registrant as of, and for, the periods presented in this
      report;                                              
|   |                                                                                                                                                                                                                                                                                                                                                              
|4. | The registrants other certifying officers and I are
      responsible for establishing and maintaining disclosure controls and
      procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and
      internal control over financial reporting (as defined in Exchange Act
      Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
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|   | (a)                                                                                                                                                                                                                                                                                                                                                          
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|   | (b)                                                                                                                                                                                                                                                                                                                                                          
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|   | (c)                                                                                                                                                                                                                                                                                                                                                          
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|   | (d)                                                                                                                                                                                                                                                                                                                                                          
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|5. | The registrants other certifying officers and I have
      disclosed, based on our most recent evaluation of internal control over
      financial reporting, to the registrants auditors and to the audit
      committee of the registrants board of directors (or persons performing
      the equivalent functions):                                  
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|   | (a)                                                                                                                                                                                                                                                                                                                                                          
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|   | (b)                                                                                                                                                                                                                                                                                                                                                          
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|Date: May 10, 2011                                                           | 
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|                                                                             | 
|/s/ Thomas L.
      Wegman                                                   | 
|Thomas L. Wegman                                                             | 
|President,
      Principal Executive Officer and Principal Financial Officer | 

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