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                                                                    EXHIBIT 10.2

                             COR Therapeutics, Inc.

                4.50% Convertible Senior Notes due June 15, 2006

                         Registration Rights Agreement
                         -----------------------------



                                                                   June 11, 2001

Goldman, Sachs & Co.
Robertson Stephens, Inc.
Credit Suisse First Boston Corporation
CIBC World Markets Corp.
Needham & Company, Inc.
 Goldman, Sachs & Co.
85 Broad Street
New York, New York  10004

Ladies and Gentlemen:

     COR Therapeutics, Inc., a Delaware corporation (the "Company"), proposes to
issue and sell to you  (the "Purchasers") upon the terms set forth in a purchase
agreement dated June 6, 2001 (the "Purchase Agreement"), between the Purchasers
and the Company, its 4.50% Convertible Senior Notes due June 15, 2006 (the
"Securities").  As an inducement to the Purchasers to enter into the Purchase
Agreement and in satisfaction of a condition to the obligations of the
Purchasers thereunder, the Company agrees with the Purchasers, (i) for the
benefit of the Purchasers and (ii) for the benefit of the Holders (as defined
below) from time to time of the Registrable Securities (as defined below),
including the Purchasers, as follows:

     1.  Definitions.  Capitalized terms used herein without definition shall
have the meanings ascribed to them in the Purchase Agreement or the Offering
Circular, each dated June 6, 2001, in respect of the Securities.  As used in
this Agreement, the following capitalized defined terms shall have the following
meanings:

     "Act" or "Securities Act" means the United States Securities Act of 1933,
as amended.

     "Affiliate" of any specified person means any other person which, directly
or indirectly, is in control of, is controlled by, or is under common control
with such specified person.  For purposes of this definition, "control" of a
person means the power, direct or indirect, to direct or cause the direction of
the management and policies of such person whether by contract or otherwise; and
the terms "controlling" and "controlled" have meanings correlative to the
foregoing.
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     "Closing Date" means the First Time of Delivery as defined in the Purchase
Agreement.

     "Commission" means the United States Securities and Exchange Commission.

     "Common Stock" means the common stock, par value $0.0001 per share, of the
Company, and any securities of the Company or any successor which may be
issuable upon conversion of the Securities pursuant to Article Eleven of the
Indenture.

     "DTC" means The Depository Trust Company.

     "Effectiveness Period" has the meaning set forth in Section 2(b) hereof.

     "Electing Holder" means any Holder of Registrable Securities that has
returned a properly completed and signed Notice and Questionnaire to the Company
in accordance with Section 3(b) hereof.

     "Exchange Act" means the United States Securities Exchange Act of 1934, as
amended.

     "Holder" means any person that is the record owner of Registrable
Securities (and includes any person that has a beneficial interest in any
Registrable Security in book-entry form).

     "Indenture" means the Indenture, dated as of June 11, 2001, between the
Company and Firstar Bank, N.A., as Trustee, as amended and supplemented from
time to time in accordance with its terms.

     "Managing Underwriters" means the investment banker or investment bankers
and manager or managers that shall administer an underwritten offering, if any,
as set forth in Section 6 hereof.

     "Person" means an individual, partnership, corporation, limited liability
company, trust or unincorporated organization, or a government or agency or
political subdivision thereof.

     "Prospectus" means the prospectus included in any Shelf Registration
Statement (including, without limitation, a prospectus that discloses
information previously omitted from a prospectus filed as part of an effective
registration statement in reliance upon Rule 430A under the Act), as amended or
supplemented by any prospectus supplement, with respect to the terms of the
offering of any portion of the Registrable Securities.

     "Registrable Security" means any Security and any share of Common Stock
issuable upon conversion or repurchase thereof except any such Security or share
of Common Stock which (i) has been effectively registered under the Securities
Act and sold in a manner contemplated by the Shelf Registration Statement, (ii)
has been transferred in compliance with Rule 144 under the Securities Act (or
any successor provision thereto) or is transferable pursuant to paragraph (k) of
such Rule 144 (or any successor provision thereto) ("Rule 144(k)"), or (iii) has
otherwise been transferred and a new Security or share of Common Stock not

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subject to transfer restrictions under the Securities Act has been delivered by
or on behalf of the Company in accordance with Section 3.5(b) of the Indenture.

     "Shelf Registration" means a registration effected pursuant to Section 2
hereof.

     "Shelf Registration Statement" means a shelf registration statement of the
Company pursuant to the provisions of Section 2 hereof filed with the Commission
which covers some or all of the Registrable Securities, as applicable, on an
appropriate form under Rule 415 under the Act, or any similar rule that may be
adopted by the Commission, amendments and supplements to such registration
statement, including post-effective amendments, in each case including the
Prospectus contained therein, all exhibits thereto and all material incorporated
by reference therein.

     "Underwriter" means any underwriter of Registrable Securities in connection
with an offering thereof under a Shelf Registration Statement.

     2.   Shelf Registration.

     (a)  The Company shall, no later than 90 calendar days following the
Closing Date, file with the Commission a Shelf Registration Statement relating
to the offer and sale of the Registrable Securities by the Holders from time to
time in accordance with the methods of distribution elected by such Holders and
set forth in such Shelf Registration Statement and, thereafter, shall use its
reasonable efforts to cause such Shelf Registration Statement to be declared
effective under the Act within 180 calendar days following the Closing Date;
provided, however, that the Company may, upon written notice to all the Holders,
postpone having the Shelf Registration Statement declared effective for a
reasonable period not to exceed 90 days if the Company possesses material non-
public information, the disclosure of which would have a material adverse effect
on the Company and its subsidiaries taken as a whole; provided, further,
however, that no Holder shall be entitled to have the Registrable Securities
held by it covered by such Shelf Registration unless such Holder is an Electing
Holder.

     (b)  The Company shall use its reasonable efforts:

          (i) To keep the Shelf Registration Statement continuously effective in
     order to permit the Prospectus forming part thereof to be usable by Holders
     until the earliest of (1) the sale of all Registrable Securities registered
     under the Shelf Registration Statement; (2) the expiration of the period
     referred to in Rule 144(k) with respect to all Registrable Securities held
     by Persons that are not Affiliates of the Company; and (3) two years from
     the date (the "Effective Date") such Shelf Registration Statement is
     declared effective (such period being called the "Effectiveness Period");
     and

          (ii) After the Shelf Registration Statement is declared effective by
     the Commission, upon the request of an Electing Holder, to take action
     reasonably necessary to register the sale of any Registrable Securities of
     such Electing Holder and to identify such Electing Holder as a selling
     securityholder.

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The Company shall be deemed not to have used its reasonable efforts to keep the
Shelf Registration Statement effective during the requisite period if the
Company voluntarily takes any action that would result in Holders of Registrable
Securities covered thereby not being able to offer and sell any such Registrable
Securities during that period, unless such action is required by applicable law
and the Company thereafter promptly complies with the requirements of paragraph
3(k) below.

     (c) The Company may suspend the use of the Prospectus for a period not to
exceed 45 days in any 90-day period or an aggregate of 90 days in any 365-day
period if the Board of Directors of the Company shall have determined in good
faith that because of valid business reasons (not including avoidance of the
Company's obligations hereunder), including the acquisition or divestiture of
assets, pending corporate developments and similar events, it is in the best
interests of the Company to suspend such use, and prior to suspending such use
the Company provides the Holders with written notice of such suspension, which
notice need not specify the nature of the event giving rise to such suspension.

     (d) Without limiting the remedies available to the Electing Holders under
Section 7 hereof, the Company acknowledges that any failure by the Company to
comply with its obligations under Section 2(a) hereof may result in material
irreparable injury to the Purchasers or the Electing Holders for which there is
no adequate remedy at law, that it will not be possible to measure damages for
such injuries precisely and that, in the event of any such failure, the
Purchasers or any Electing Holder may obtain such relief as may be required to
specifically enforce the Company's obligations under Section 2(a) hereof.

     3.  Registration Procedures.  In connection with any Shelf Registration
Statement, the following provisions shall apply:

     (a) The Company shall prepare and file with the Commission the Shelf
Registration Statement on the appropriate form under the Act (x) which form
shall be selected by the Company, (y) which form shall be available for the sale
of the Registrable Securities by the Electing Holders and (z) which Shelf
Registration Statement and any amendment thereto and the Prospectus forming part
thereof and any amendment or supplement thereto (and each other document
incorporated therein by reference in each case) shall comply as to form in all
material respects with the Act and the Exchange Act and the respective rules and
regulations thereunder and shall include (or incorporate by reference) all
financial statements required by the Commission to be filed therewith, and shall
use its reasonable efforts to cause such Shelf Registration Statement to become
effective and remain effective in accordance with Section 2 hereof.

         (b)  (1)  The Company shall mail the Notice and Questionnaire to the
     Holders of Registrable Securities not less than 25 calendar days prior to
     the time the Company intends in good faith to have the Shelf Registration
     Statement declared effective.   Any Person that acquires any Registrable
     Securities from an Electing Holder

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     in compliance with the applicable provisions of the Securities (excluding
     any Registrable Securities that were not identified in the Notice and
     Questionnaire delivered by such Electing Holder) will be entitled to have
     such Registrable Securities included in the Shelf Registration Statement so
     long as such transferee provides the Company with an updated Notice and
     Questionnaire prior to the Questionnaire Deadline (as defined below).
     Subject to Section 3(b)(2) hereof, no Holder of Registrable Securities
     shall be entitled to be named as a selling securityholder in the Shelf
     Registration Statement as of the Effective Date, and no Holder of
     Registrable Securities shall be entitled to use the Prospectus forming a
     part thereof for offers and resales of Registrable Securities at any time,
     unless such Holder has returned a completed and signed Notice and
     Questionnaire to the Company by the deadline for response set forth therein
     (the "Questionnaire Deadline"), such response deadline to be on a date not
     less than 25 calendar days after the date of mailing of the Notice and
     Questionnaire by the Company.

          (2) After the Effective Date of the Shelf Registration Statement, the
     Company shall, upon the request of any Holder of Registrable Securities
     that is not then an Electing Holder, as promptly as reasonably practicable,
     send a Notice and Questionnaire to such Holder. The Company shall not be
     required to take any action to name such Holder as a selling securityholder
     in the Shelf Registration Statement until such Holder has returned a
     completed and signed Notice and Questionnaire to the Company. Following its
     receipt of such Notice and Questionnaire, the Company will reasonably
     promptly include the Registrable Securities covered thereby in the Shelf
     Registration Statement (if not previously included).

          (3) If such complete Notice and Questionnaire is received by the
     Company before 10 days prior to the Effective Date, such Holder shall be
     entitled to have its Registrable Securities included in the Shelf
     Registration Statement at the Effective Date. If the Company receives such
     complete Notice and Questionnaire after the 10th day prior to the Effective
     Date, the Registrable Securities covered by the Notice and Questionnaire
     will be included in the Shelf Registration Statement as promptly as
     reasonably practicable after receipt of such Notice and Questionnaire.

          (4) In the event that the Company receives such complete Notice and
     Questionnaire after the Shelf Registration Statement has been declared
     effective, the Company will, as promptly as reasonably practicable
     following receipt of the complete Notice and Questionnaire, file any
     amendments to the Shelf Registration Statement or supplements related to
     the Prospectus as are necessary to permit such Holder to deliver the
     Prospectus to purchasers of the Registrable Securities.  The Company shall
     use reasonable efforts to cause such post-effective amendment to the Shelf
     Registration Statement to be declared effective within 45 days of the
     filing of such post-effective amendment.  The Company may take reasonable
     steps to aggregate the addition of Registrable Securities of more than one
     Holder for purposes of filing amendments to the Shelf  Registration
     Statement or supplements to the Prospectus so as to reduce the

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     need for multiple amendments or supplements, but the Company shall not
     utilize this provision to delay any filing requested by any of the
     Purchasers.

     (c) The Company shall furnish to the Holders, prior to the filing thereof
with the Commission, a copy of any Shelf Registration Statement, and each
amendment thereof and each amendment or supplement, if any, to the Prospectus
included therein and shall use reasonable efforts to reflect in each such
document, when so filed with the Commission, such comments as the Holders
reasonably may propose.

     (d) The Company shall take such action as may be necessary so that (i) any
Shelf Registration Statement and any amendment thereto and any Prospectus
forming part thereof and any amendment or supplement thereto (and each report or
other document incorporated therein by reference in each case) complies in all
material respects with the Securities Act and the Exchange Act and the
respective rules and regulations thereunder, (ii) any Shelf Registration
Statement and any amendment thereto does not, when it becomes effective, contain
an untrue statement of a material fact or omit to state a material fact required
to be stated therein or necessary to make the statements therein not misleading
and (iii) any Prospectus forming part of any Shelf Registration Statement, and
any amendment or supplement to such Prospectus, does not include an untrue
statement of a material fact or omit to state a material fact necessary in order
to make the statements, in the light of the circumstances under which they were
made, not misleading.

     (e)  (i)  The Company shall advise the Purchasers, the Electing Holders and
     the Managing Underwriter or Underwriters promptly and, if requested by the
     Purchasers or any Electing Holder, confirm such advice in writing:

               (1)  when a Shelf Registration Statement and any amendment
          thereto has been filed with the Commission and when the Shelf
          Registration Statement or any post-effective amendment thereto has
          become effective in each case making a public announcement thereof by
          release made to Reuters Economic Services and Bloomberg Business News;

               (2)  when the Company receives any request by the Commission for
          amendments or supplements to the Shelf Registration Statement or the
          Prospectus included therein or for additional information;

               (3)  when the Commission issues any stop order suspending
          effectiveness of the Shelf Registration Statement or initiates any
          proceedings for that purpose;

               (4)  when the Company receives any notification with respect to
          the suspension of the qualification of the securities included therein
          for sale in any jurisdiction or the initiation of any proceeding for
          such purpose; and

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         (ii) The Company shall, as promptly as reasonably practicable, advise
     the Purchasers, the Electing Holders and each Managing Underwriter, if any,
     of the happening of any event that requires the making of any changes to
     the Shelf Registration Statement or the Prospectus so that, as of such
     date, the Shelf Registration Statement and the Prospectus do not contain an
     untrue statement of a material fact and do not omit to state a material
     fact required to be stated therein or necessary to make the statements
     therein (in the case of the Prospectus, in light of the circumstances under
     which they were made) not misleading (which advice shall be accompanied by
     an instruction to suspend the use of the Prospectus until the requisite
     changes have been made).

     (f) The Company shall use reasonable efforts to prevent the issuance, and
if issued to obtain the withdrawal, of any order suspending the effectiveness of
any Shelf Registration Statement at the earliest possible time.

     (g) The Company shall furnish to each Electing Holder, counsel for the
Purchasers, each Purchaser and each Managing Underwriter, if any, with respect
to a Shelf Registration Statement, without charge, at least one copy of such
Shelf Registration Statement and any post-effective amendment thereto, including
financial statements and schedules, and, if the Electing Holder so requests in
writing, all exhibits (including those incorporated by reference).

     (h) The Company shall, during the Effectiveness Period, deliver to each
Electing Holder and each Managing Underwriter, if any, with respect to a Shelf
Registration Statement, without charge, as many copies of the Prospectus
(including each preliminary Prospectus) included in such Shelf Registration
Statement and any amendment or supplement thereto as such Electing Holder may
reasonably request; and the Company consents (except during the continuance of
any event described in Section 3(e)(ii)) to the use of the Prospectus or any
amendment or supplement thereto by each of the Electing Holders in connection
with the offering and sale of the Registrable Securities covered by the
Prospectus and any amendment or supplement thereto during the Effectiveness
Period.

     (i) Prior to any offering of Registrable Securities pursuant to any Shelf
Registration Statement, the Company shall register or qualify or cooperate with
the Purchasers and their counsel in connection with the registration or
qualification of such Registrable Securities for offer and sale under the
securities or blue sky laws of such jurisdictions as any such Electing Holders
reasonably request in writing and do any and all other acts or things necessary
or advisable to enable the offer and sale in such jurisdictions of the
Registrable Securities covered by such Shelf Registration Statement; provided,
however, that in no event shall the Company be obligated to (i) qualify as a
foreign corporation or as a dealer in securities in any jurisdiction where it
would not otherwise be required to so qualify but for this Section 3(i), (ii)
file any general consent to service of process or taxation in any jurisdiction
where it is not as of the date hereof then so subject or (iii) subject itself to
taxation in any jurisdiction if it is not so subject.

     (j) Unless any Registrable Securities shall be in book-entry only form, the
Company shall cooperate with the Electing Holders to facilitate the timely
preparation and delivery of

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certificates representing Registrable Securities to be sold pursuant to any
Shelf Registration Statement free of any restrictive legends and in such
permitted denominations and registered in such names as Electing Holders may
request in connection with the sale of Registrable Securities pursuant to such
Shelf Registration Statement.

     (k) Upon the occurrence of any event contemplated by paragraph 3(e)(ii)
above, the Company shall promptly prepare a post-effective amendment to any
Shelf Registration Statement or an amendment or supplement to the related
Prospectus or file any other required document so that, as thereafter delivered
to purchasers of the Registrable Securities included therein, the Prospectus
will not include an untrue statement of a material fact or omit to state any
material fact necessary to make the statements therein, in the light of the
circumstances under which they were made, not misleading.  If the Company
notifies the Electing Holders of the occurrence of any event contemplated by
paragraph 3(e)(ii) above, the Electing Holders shall suspend the use of the
Prospectus until the requisite changes to the Prospectus have been made.

     (l) Not later than the effective date of any Shelf Registration Statement
hereunder, the Company shall provide a CUSIP number for the Securities
registered under such Shelf Registration Statement.

     (m) The Company shall use reasonable efforts to comply with all applicable
rules and regulations of the Commission and shall make generally available to
their security holders or otherwise provide in accordance with Section 11(a) of
the Securities Act as soon as practicable after the effective date of the
applicable Shelf Registration Statement an earnings statement satisfying the
provisions of Section 11(a) of the Securities Act.

     (n) The Company shall cause the Indenture and the Securities to be
qualified under the Trust Indenture Act in a timely manner; and in connection
with such qualification, the Company shall cooperate with the Trustee under the
Indenture and the Holders (as defined in the Indenture) to effect such changes
to the Indenture as may be required for such Indenture to be so qualified in
accordance with the terms of the Trust Indenture Act; and the Company shall
execute and use all reasonable efforts to cause the Trustee to execute, all
documents that may be required to effect such changes and all other forms and
documents required to be filed with the Commission to enable such Indenture to
be so qualified in a timely manner.

     (o) In the event of an underwritten offering as set forth in Section 6
herein, the Company shall, if requested, promptly include or incorporate in a
Prospectus supplement or post-effective amendment to a Shelf Registration
Statement, such information as the Managing Underwriter or Underwriters
reasonably request to be included therein and to which the Company does not
reasonably object and shall make all required filings of such Prospectus
supplement or post-effective amendment as soon as practicable after it is
notified of the matters to be included or incorporated in such Prospectus
supplement or post-effective amendment.

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     (p) The Company shall enter into such customary agreements (including
underwriting agreements in customary form) to take all other appropriate actions
in order to expedite or facilitate the registration or the disposition of the
Registrable Securities, and in connection therewith, if an underwriting
agreement is entered into, cause the same to contain indemnification provisions
and procedures substantially identical to those set forth in Section 5 (or such
other provisions and procedures acceptable to the Managing Underwriters, if any)
with respect to all parties to be indemnified pursuant to Section 5.

     (q)  The Company shall:

          (i)   make reasonably available for inspection by one or more
     representative of the Electing Holders designated in writing by the Holders
     of a majority of the Registrable Securities to be registered thereunder,
     any Underwriter participating in any disposition pursuant to such Shelf
     Registration Statement, and any attorney, accountant or other agent
     retained by such representative or any such Underwriter all relevant
     financial and other records, pertinent corporate documents and properties
     of the Company and its subsidiaries;

          (ii)  cause the Company's officers, directors and employees to make
     reasonably available for inspection all relevant information reasonably
     requested by such representative or any such Underwriter, attorney,
     accountant or agent in connection with any such Shelf Registration
     Statement, in each case, as is customary for similar due diligence
     examinations; provided, however, that any information that is designated in
     writing by the Company, in good faith, as confidential at the time of
     delivery of such information shall be kept confidential by such
     representative, any Holders or any such Underwriter, attorney, accountant
     or agent, unless such disclosure is made in connection with a court
     proceeding or required by law, or such information becomes available to the
     public generally or through a third party without an accompanying
     obligation of confidentiality;

          (iii) make such representations and warranties to the Electing
     Holders and the Underwriters, if any, in form, substance and scope as are
     customarily made by the Company to underwriters in primary underwritten
     offerings and covering matters including, but not limited to, those set
     forth in the Purchase Agreement;

          (iv)  use its reasonable efforts to obtain opinions of counsel to the
     Company and updates thereof (which counsel and opinions (in form, scope and
     substance) shall be reasonably satisfactory to the Managing Underwriters,
     if any) addressed to each Electing Holder and the Underwriters, if any,
     covering such matters as are customarily covered in opinions requested in
     underwritten offerings and such other matters as may be reasonably
     requested by such Electing Holders and Underwriters (it being agreed that
     the matters to be covered by such opinion or written statement by such
     counsel delivered in connection with such opinions shall include in
     customary form, without limitation, as of the date of the opinion and as of
     the effective date of the Shelf

                                      -9-
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     Registration Statement or most recent post-effective amendment thereto, as
     the case may be, the absence from such Shelf Registration Statement and the
     prospectus included therein, as then amended or supplemented, including the
     documents incorporated by reference therein, of an untrue statement of a
     material fact or the omission to state therein a material fact required to
     be stated therein or necessary to make the statements therein not
     misleading);

          (v) use its reasonable efforts to obtain "cold comfort" letters and
     updates thereof from the independent public accountants of the Company
     (and, if necessary, any other independent public accountants of any
     subsidiary of the Company or of any business acquired by the Company for
     which financial statements and financial data are, or are required to be,
     included in the Shelf Registration Statement), addressed to each Electing
     Holder and the Underwriters, if any, in customary form and covering matters
     of the type customarily covered in "cold comfort" letters in connection
     with primary underwritten offerings;

          (vi) deliver such documents and certificates as may be reasonably
     requested by any such Electing Holders and the Managing Underwriters, if
     any, including those to evidence compliance with Section 3(d) and with any
     customary conditions contained in the underwriting agreement or other
     agreement entered into by the Company.

     The foregoing actions set forth in clauses (iii), (iv), (v) and (vi) of
     this Section 3(p) shall be performed at each closing under any underwritten
     offering to the extent required thereunder (including at any closing
     relating to the exercise by underwriters of their over-allotment options,
     if any).

     (r)  The Company will use its reasonable efforts to cause the Stock
issuable upon conversion of the Securities to be admitted for quotation on the
Nasdaq National Market or other stock exchange or trading system on which the
Stock primarily trades on or prior to the effective date of any Shelf
Registration Statement hereunder.

     (s)  In the event that any broker-dealer registered under the Exchange Act
shall be an "Affiliate" (as defined in Rule 2720(b)(i) of the Rules of Conduct
of the National Association of Securities Dealers, Inc. (the "NASD") (or any
successor or analogous provision thereto)) of the Company or has a "Conflict of
Interest" (as defined in Rule 2720(b)(7) of the Rules of Conduct of the NASD (or
any successor an analogous provision thereto)) and such broker-dealer shall
underwrite, participate as a member of an underwriting syndicate or selling
group or "assist in the distribution" (within the meaning of such rule) of any
Registrable Securities, whether as a holder of such Registrable Securities or as
an underwriter, a placement or sales agent or a broker or dealer in respect
thereof, or otherwise, assist such broker-dealer (at the expense of such broker-
dealer) in complying with the requirements of such rule, including, without
limitation, by (A) engaging a "qualified independent underwriter" (as defined in
such rule) to participate in the preparation of the registration statement
relating to such Registrable Securities, to exercise usual standards of due
diligence in respect thereto and to recommend the public offering price of such
Registrable Securities, (B) indemnifying such

                                      -10-
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qualified independent underwriter to the extent of the indemnification of
Underwriters provided in Section 5 hereof, and (C) providing such information to
such broker-dealer as may be required in order for such broker-dealer to comply
with the requirements of the Rules of Conduct of the NASD.

     (t)  The Company shall use reasonable efforts to take all other steps
necessary to effect the registration, offering and sale of the Registrable
Securities covered by the Shelf Registration Statement contemplated hereby.

     (u)  The Company may require each Electing Holder with respect to a Shelf
Registration Statement to furnish to the Company such information regarding the
Electing Holder and the distribution of Registrable Securities held by such
Electing Holder as may be required by applicable law or regulation for inclusion
in such Shelf Registration Statement and the Company may exclude from such
registration the Registrable Securities of any Electing Holder that fails to
furnish such information within a reasonable time after receiving such request.

     4.   Registration Expenses.  Except as otherwise provided in Section 6, the
Company shall bear all fees and expenses incurred in connection with the
performance of its obligations under Sections 2 and 3 hereof and shall bear or
reimburse the Electing Holders for the reasonable fees and disbursements of a
single counsel selected by a plurality of all Electing Holders who own an
aggregate of not less than 25% of the Registrable Securities covered by the
Shelf Registration Statement to act as counsel therefor in connection therewith.
Each Electing Holder shall pay all underwriting discounts and commissions and
transfer taxes, if any, relating to the sale or disposition of such Electing
Holder's Registrable Securities pursuant to the Shelf Registration Statement.

     5.   Indemnification and Contribution.

     (a)  In connection with any Shelf Registration Statement, the Company shall
indemnify and hold harmless each Electing Holder, each Underwriter who
participates in an offering of Registrable Securities, each person, if any, who
controls any of such parties within the meaning of Section 15 of the Securities
Act or Section 20 of the Exchange Act and each of their respective directors,
officers, employees, trustees and agents, as follows:

          (i)  against any and all loss, liability, claim, damage and expense
     whatsoever, including any amounts paid in settlement of any investigation,
     litigation, proceeding or claim, joint or several, as incurred, arising out
     of any untrue statement or alleged untrue statement of a material fact
     contained in any Shelf Registration Statement (or any amendment thereto)
     covering Registrable Securities, including all documents incorporated
     therein by reference, or the omission or alleged omission therefrom of a
     material fact required to be stated therein or necessary to make the
     statements therein not misleading or arising out of any untrue statement or
     alleged untrue statement of a material fact contained in any Prospectus (or
     any amendment or supplement thereto) or

                                      -11-
<PAGE>

     the omission or alleged omission therefrom of a material fact necessary in
     order to make the statements therein, in the light of the circumstances
     under which they were made, not misleading; provided, that the Company
     shall not be liable under this clause (i) for any settlement of any action
     effected without its written consent, which consent shall not be
     unreasonably withheld; and

          (ii)  against any and all expenses whatsoever, as incurred (including
     reasonable fees and disbursements of counsel chosen by the Electing
     Holders, such Electing Holder or any Underwriter (except to the extent
     otherwise expressly provided in Section 5(c) hereof)), reasonably incurred
     in investigating, preparing or defending against any litigation, or any
     investigation or proceeding by any court or governmental agency or body,
     commenced or threatened, or any claim whatsoever based upon any such untrue
     statement or omission, or any such alleged untrue statement or omission, to
     the extent that any such expense is not paid under subparagraph (i) of this
     Section 5(a);

provided that this indemnity shall not apply to any loss, liability, claim,
damage or expense to the extent arising out of an untrue statement or omission
or alleged untrue statement or omission made in reliance upon and in conformity
with written information furnished to the Company by such Electing Holder or any
Underwriter in writing expressly for use in the Shelf Registration Statement (or
any amendment thereto) or any Prospectus (or any amendment or supplement
thereto).  Any amounts advanced by the Company to an indemnified party pursuant
to this Section 5 as a result of such losses shall be returned to the Company if
it shall be finally determined by such a court in a judgment not subject to
appeal or final review that such indemnified party was not entitled to
indemnification by the Company.

     (b)  Each Electing Holder shall agree, severally and not jointly, to
indemnify and hold harmless the Company, each Underwriter who participates in an
offering of Registrable Securities and the other Electing Holders and each of
their respective directors, officers (including each officer of the Company who
signed the Shelf Registration Statement), employees, trustees and agents and
each Person, if any, who controls the Company, any Underwriter or any other
Electing Holder within the meaning of Section 15 of the Securities Act or
Section 20 of the Exchange Act, from and against any and all loss, liability,
claim, damage and expense whatsoever described in the indemnity contained in
Section 5(a)(i) and (ii) hereof, as incurred, but only with respect to untrue
statements or omissions, or alleged untrue statements or omissions, made in the
Shelf Registration Statement (or any amendment thereto) or any Prospectus (or
any amendment or supplement thereto) in reliance upon and in conformity with
written information furnished to the Company by such Electing Holder expressly
for use in the Shelf Registration Statement (or any amendment thereto) or any
Prospectus (or any amendment or supplement thereto); provided, however, that, no
such Electing Holder shall be liable for any claims hereunder in excess of the
amount of net proceeds received by such Electing Holder from the sale of
Registrable Securities pursuant to the Shelf Registration Statement.

                                      -12-
<PAGE>

     (c)  Each indemnified party shall give prompt notice to each indemnifying
party of any action commenced against it in respect of which indemnity may be
sought hereunder, enclosing a copy of all papers served on such indemnified
party, but failure to so notify an indemnifying party shall not relieve it of
any liability which it may have to the indemnified party otherwise than on
account of this indemnity agreement.  An indemnifying party may participate at
its own expense in the defense of any such action.  If an indemnifying party so
elects within a reasonable time after receipt of such notice, such indemnifying
party, jointly with any other indemnifying party, may assume the defense of such
action with counsel chosen by it and approved by the indemnified party or
parties defendant in such action, provided that if any such indemnified party
reasonably determines that there may be legal defenses available to such
indemnified party which are different from or in addition to those available to
such indemnifying party or that representation of such indemnifying party and
any indemnified party by the same counsel would present a conflict of interest,
then such indemnifying party or parties shall not be entitled to assume such
defense.  If an indemnifying party is not entitled to assume the defense of such
action as a result of the proviso to the preceding sentence, counsel for such
indemnifying party shall be entitled to conduct the defense of such indemnifying
party and counsel for each indemnified party or parties shall be entitled to
conduct the defense of such indemnified party or parties.  If an indemnifying
party assumes the defense of an action in accordance with and as permitted by
the provisions of this paragraph, such indemnifying party shall not be liable
for any fees and expenses of counsel for the indemnified parties incurred
thereafter in connection with such action.  In no event shall the indemnifying
party or parties be liable for the fees and expenses of more than one counsel
(in addition to any local counsel) separate from its own counsel for all
indemnified parties in connection with any one action or separate but similar or
related actions in the same jurisdiction arising out of the same general
allegations or circumstances.

     (d)  In order to provide for just and equitable contribution in
circumstances in which the indemnity provision provided for in this Section 5 is
for any reason held to be unavailable to an indemnified party although
applicable in accordance with its terms, then each indemnifying party shall
contribute to the aggregate losses, liabilities, claims, damages and expenses of
the nature contemplated by such indemnity agreement incurred by such indemnified
party, as incurred; provided that no Person guilty of fraudulent
misrepresentation (within the meaning of Section 11(f) of the Securities Act)
shall be entitled to contribution from any Person that was not guilty of such
fraudulent misrepresentation.  Each such indemnifying party shall contribute to
such aggregate losses, liabilities, claims, damages and expenses of such
indemnified party of the nature contemplated by such indemnity agreement in such
proportion as shall be appropriate to reflect the relative fault of such
indemnifying party, on the one hand, and such indemnified party, on the other
hand, with respect to the statements or omissions which resulted in such loss,
liability, claim, damage or expense, or action in respect thereof, as well as
any other relevant equitable considerations.  The relative fault of an
indemnifying party, on the one hand, and of an indemnified party, on the other
hand, shall be determined by reference to, among other things, whether the
untrue or alleged untrue statement of a material fact or the omission or alleged
omission to state a material fact relates to information supplied by such
indemnifying party, on the one hand, or by or on behalf of such indemnified
party, on the other,

                                      -13-
<PAGE>

and the parties' relative intent, knowledge, access to information and
opportunity to correct or prevent such statement or omission. The Company, the
Purchasers and the Holders of the Registrable Securities agree that it would not
be just and equitable if contribution pursuant to this Section 5(d) were to be
determined by pro rata allocation or by any other method of allocation that does
not take into account the relevant equitable considerations. For purposes of
this Section 5(d), each director, officer, employee, trustee, agent and Person,
if any, who controls a Purchaser or Holder within the meaning of Section 15 of
the Securities Act or Section 20 of the Exchange Act shall have the same rights
to contribution as such Purchaser or Holder, as the case may be, and each
director, officer, employee, trustee and agent of the Company, and each Person,
if any, who controls the Company within the meaning of Section 15 of the
Securities Act or Section 20 of the Exchange Act shall have the same rights to
contribution as the Company. No party shall be liable for contribution with
respect to any action, suit, proceeding or claim settled without its written
consent, which consent shall not be unreasonably withheld.

     (e)  The Company may require, as a condition to including any Registrable
Securities in any Registration Statement filed and to entering into any
underwriting agreement with respect thereto, that the Company shall have
received an undertaking reasonably satisfactory to it from the holder of such
Registrable Securities and from each Underwriter named in any such underwriting
agreement, severally and not jointly, to comply with the provisions of
paragraphs (a) through (d) of this Section 5.

     The indemnity and contribution provisions contained in this Section 5 shall
remain operative and in full force and effect regardless of (i) any termination
of this Agreement, (ii) any investigation made by or on behalf of the Managing
Underwriters, if any, any Electing Holder or any Person controlling any Electing
Holder, or by or on behalf of the Company, its officers or directors or any
Person controlling the Company and (iii) any sale of Registrable Securities
pursuant to the Shelf Registration Statement.

     6.   Underwritten Offering.  The Electing Holders who desire to do so may
sell Registrable Securities in an underwritten offering upon request to the
Company.  In any such underwritten offering, the investment banker or bankers
and manager or managers that will administer the offering will be selected by,
and the underwriting arrangements with respect thereto will be approved by the
Holders of a majority of the Registrable Securities to be included in such
offering; provided, however, that (i) such investment bankers and managers and
underwriting arrangements must be reasonably satisfactory to the Company and
(ii) the Company shall not be obligated to arrange for more than one
underwritten offering during the Effectiveness Period.  No Holder may
participate in any underwritten offering contemplated hereby unless such Holder
(a) agrees to sell such Holder's Registrable Securities in accordance with any
approved underwriting arrangements, (b) completes and executes all reasonable
questionnaires, powers of attorney, indemnities, underwriting agreements, lock-
up letters and other documents required under the terms of such approved
underwriting arrangements and (c) at least 20% of the outstanding Registrable
Securities are included in such underwritten offering.  The Holders
participating in any underwritten offering shall be responsible for any

                                      -14-
<PAGE>

expenses customarily borne by selling securityholders, including underwriting
discounts and commissions and fees and expenses of counsel to the selling
securityholders and shall reimburse the Company for the fees and disbursements
of their counsel, their independent public accountants and any printing expenses
incurred in connection with such underwritten offerings. Notwithstanding the
foregoing or the provisions of Section 3(o) hereof, upon receipt of a request
from the Managing Underwriter or a representative of Holders of a majority of
the Registrable Securities outstanding to prepare and file an amendment or
supplement to the Shelf Registration Statement and Prospectus in connection with
an underwritten offering, the Company may delay the filing of any such amendment
or supplement for up to 90 days if the Company in good faith has a valid
business reason for such delay.

     7.   Liquidated Damages

     (a)  Pursuant to Section 2(a) hereof, the Company may, upon written notice
to all the Holders, postpone having the Shelf Registration Statement declared
effective for a reasonable period not to exceed 90 days if the Company possesses
material non-public information, the disclosure of which would have a material
adverse effect on the Company and its subsidiaries taken as a whole.
Notwithstanding any such postponement, if (i) on or prior to the 90th day
following the Closing Date, a Shelf Registration Statement has not been filed
with the Commission or (ii) on or prior to the 180th day following the Closing
Date, such Shelf Registration Statement is not declared effective by the
Commission (each, a "Registration Default"), the Company shall be required to
pay liquidated damages ("Liquidated Damages"), from and including the day
following such Registration Default until such Shelf Registration Statement is
either so filed or so filed and subsequently declared effective, as applicable,
or, if earlier, the end of the Effectiveness Period, at a rate per annum equal
to an additional one-quarter of one percent (0.25%) of the principal amount of
Registrable Securities, to and including the 90th day following such
Registration Default and one-half of one percent (0.5%) thereof from and after
the 91st day following such Registration Default.

     (b)  In the event that the Shelf Registration Statement ceases to be
effective (or the Holders of Registrable Securities are otherwise prevented or
restricted by the Company from effecting sales pursuant thereto) (an "Effective
Failure") for more than 45 days, whether or not consecutive, in any 90-day
period, or 90 days, whether or not consecutive, during any 12-month period, then
the Company shall pay Liquidated Damages at a rate per annum equal to an
additional one-half of one percent (0.5%) from the 46th day of the applicable
90-day period or the 91st day of the applicable 12-month period, as the case may
be, that such Shelf Registration Statement ceases to be effective (or the
Holders of Registrable Securities are otherwise prevented or restricted by the
Company from effecting sales pursuant thereto) until the earlier of (i) the time
the Shelf Registration Statement again becomes effective or the Holders of
Registrable Securities are again able to make sales under the Shelf Registration
Statement or (2) the time the Effectiveness Period expires. For the purpose of
determining an Effective Failure, days on which the Company has been obligated
to pay Liquidated Damages in accordance with the foregoing in respect of a prior
Effective Failure within the applicable 90-day or 12-month period, as the case
may be, shall not be included.

                                      -15-
<PAGE>

     (c)  In the event the Company fails to file a post-effective amendment to
the Shelf Registration Statement, or the post-effective amendment is not
declared effective, within the periods required by Section 3(b)(4), the Company
shall pay Liquidated Damages at a rate per annum equal to an additional one-half
of one percent (0.5%) from and including the date of such Registration Default
until such time as such Registration Default is cured.

     (d)  Any amounts to be paid as Liquidated Damages pursuant to paragraphs
(a), (b) or (c) of this Section shall be paid semi-annually in arrears, with the
first semi-annual payment due on the first Interest Payment Date (as defined in
the Indenture), as applicable, following the date of such Registration Default.
Such Liquidated Damages will accrue (1) in respect of the Securities at the
rates set forth in paragraphs (a), (b) or (c) of this Section, as applicable, on
the principal amount of the Securities and (2) in respect of the Common Stock
issued upon conversion of the Securities, at the rates set forth in paragraphs
(a), (b) or (c) of this Section, as applicable, applied to the Conversion Price
(as defined in the Indenture) at that time.

     (e)  Except as provided in Section 2(d), the Liquidated Damages as set
forth in this Section 7 shall be the exclusive monetary remedy available to the
Holders of Registrable Securities for such Registration Default or Effective
Failure. In no event shall the Company be required to pay Liquidated Damages in
excess of the applicable maximum amount of one-half of one percent (0.5%) set
forth above, regardless of whether one or multiple Registration Defaults exist.

     8.   Miscellaneous.

     (a)  Other Registration Rights.  The Company may in the future grant
registration rights that would permit any Person that is a third party the right
to piggy-back on any Shelf Registration Statement, provided that if the Managing
Underwriter, if any, of such offering notifies the Electing Holders that the
total amount of securities which they and the holders of such piggy-back rights
intend to include in any Shelf Registration Statement is so large as to
materially adversely affect the success of such offering (including the price at
which such securities can be sold), then only the amount, the number or kind of
securities to be offered for the account of holders of such piggy-back rights
will be reduced to the extent necessary to reduce the total amount of securities
to be included in such offering to the amount, number or kind recommended by the
Managing Underwriter prior to any reduction in the amount of Registrable
Securities to be included.

     (b)  Amendments and Waivers.  The provisions of this Agreement, including
the provisions of this sentence, may not be amended, qualified, modified or
supplemented, and waivers or consents to departures from the provisions hereof
may not be given, unless the Company has obtained the written consent of
Goldman, Sachs & Co.

     (c)  No Inconsistent Agreements.  The Company has not entered into, and on
or after the date of this Agreement will not enter into, any agreement which is
inconsistent with the

                                      -16-
<PAGE>

rights granted to the Holders of Registrable Securities in this Agreement or
otherwise conflicts with the provisions hereof. The rights granted to the
Holders hereunder do not in any way conflict with and are not inconsistent with
the rights granted to the holders of the Company's other issued and outstanding
securities under any such agreements.

     (d)  Notices.  All notices and other communications provided for or
permitted hereunder shall be made in writing by hand-delivery, first-class mail,
telex, telecopier, or air courier guaranteeing overnight delivery:

          (1)  if to a Holder, at the most current address given by such Holder
     to the Company in accordance with the provisions of this Section 8(d);

          (2)  if to the Purchasers, initially at the address set forth in the
     Purchase Agreement; and

          (3)  if to the Company, initially at its address set forth in the
     Purchase Agreement.

All such notices and communications shall be deemed to have been duly given when
received.
     The Purchasers or the Company by notice to the other may designate
additional or different addresses for subsequent notices or communications.

     (e)  Successors and Assigns.  This Agreement shall inure to the benefit of
and be binding upon the successors and assigns of each of the parties and the
Holders, including, without the need for an express assignment or any consent by
the Company thereto, subsequent Holders of Registrable Securities.  The Company
hereby agrees to extend the benefits of this Agreement to any Holder of
Registrable Securities and any such Holder may specifically enforce the
provisions of this Agreement as if an original party hereto.

     (f)  Counterparts.  This Agreement may be executed in any number of
counterparts and by the parties hereto in separate counterparts, each of which
when so executed shall be deemed to be an original and all of which taken
together shall constitute one and the same agreement.

     (g)  Headings.  The headings in this agreement are for convenience of
reference only and shall not limit or otherwise affect the meaning hereof.

     (h)  Governing Law.  This agreement shall be governed by and construed in
accordance with the laws of the State of New York, without giving effect to any
provisions relating to conflicts of laws.

     (i)  Severability.  In the event that any one or more of the provisions
contained herein, or the application thereof in any circumstances, is held
invalid, illegal or unenforceable in any respect for any reason, the validity,
legality and enforceability of any such provision in every

                                      -17-
<PAGE>

other respect and of the remaining provisions hereof shall not be in any way
impaired or affected thereby, it being intended that all of the rights and
privileges of the parties hereto shall be enforceable to the fullest extent
permitted by law.

                                      -18-
<PAGE>

     Please confirm that the foregoing correctly sets forth the agreement
between the Company and you.

                                                  Very truly yours,

                                                  COR THERAPEUTICS, INC.


                                                  By: /s/ Vaughn M. Kailian
                                                     -------------------------
                                                     Name: Vaughn M. Kailian
                                                     Title: President and Chief
                                                            Executive Officer

The foregoing Registration Rights Agreement is hereby confirmed and accepted as
of the date first above written.


Goldman, Sachs & Co.,
Robertson Stephens, Inc.
Credit Suisse First Boston Corporation
CIBC World Markets Corp.
Needham & Company, Inc.


By: /s/ Goldman, Sachs & Co.
   ----------------------------
     (Goldman, Sachs & Co.)

                                      -19-
<PAGE>

                                                                      Appendix A

                            COR THERAPEUTICS, INC.


                        INSTRUCTION TO DTC PARTICIPANTS
                        -------------------------------

                               (Date of Mailing)

                    URGENT - IMMEDIATE ATTENTION REQUESTED

                        DEADLINE FOR RESPONSE:  [DATE]
                         ------------------------------

      The Depository Trust Company ("DTC") has identified you as a DTC
Participant through which beneficial interests in the COR Therapeutics, Inc.
(the "Company") 4.50% Convertible Senior Notes due June 15, 2006 (the "Notes")
are held.  The Notes are identified by CUSIP No. 217753 AE 2.

      In accordance with the terms of the Registration Rights Agreement, dated
as of June 11, 2001, between the Company and the Purchasers named therein (the
"Registration Rights Agreement"), the Company is in the process of registering
the Notes and the shares of common stock, par value $.0001 per share (together,
the "Securities"), issuable upon conversion thereof, under the Securities Act of
1933, as amended, for resale by the beneficial owners thereof.  In order to have
their Securities included in the registration statement, the beneficial owners,
INCLUDING BENEFICIAL OWNERS RESIDENT OUTSIDE THE UNITED STATES, must complete
and return the enclosed Notice of Registration Statement and Selling
Securityholder Questionnaire (the "Notice and Questionnaire").

      It is important that beneficial owners of the Securities receive a copy of
      --------------------------------------------------------------------------
the enclosed materials as soon as possible as their rights to have the
------------------------------------------
Securities included in the registration statement depend upon their returning
the Notice and Questionnaire by [DEADLINE FOR RESPONSE].  Please forward a copy
                                 ---------------------
of the enclosed documents to each beneficial owner that holds interests in the
Securities through you.  If you require more copies of the enclosed materials or
have any questions pertaining to this matter, please contact:

          COR Therapeutics, Inc.
          256 East Grand Avenue
          South San Francisco, California 94080
          Attention: Corporate Counsel
          Telephone: (650) 246-7315
          Fax: (650) 244-9208.
<PAGE>

                        NOTICE OF REGISTRATION STATEMENT
                    AND SELLING SECURITYHOLDER QUESTIONNAIRE
<PAGE>

                             COR Therapeutics, Inc.

                        Notice of Registration Statement
                                      and
                      Selling Securityholder Questionnaire
                                     (Date)

     COR Therapeutics, Inc. (the "Company") has filed or intends shortly to file
with the United States Securities and Exchange Commission (the "Commission") a
preliminary registration statement on Form S-3 (the "Shelf Registration
Statement") for the registration and resale under the United States Securities
Act of 1933, as amended (the "Securities Act"), of the Company's 4.50%
Convertible Senior Notes due June 15, 2006 (CUSIP No. 217753 AE 2) (the
"Notes"), and Common Stock issuable upon conversion thereof, in accordance with
the terms of the Registration Rights Agreement, dated as of June 11, 2001 (the
"Registration Rights Agreement"), between the Company and the purchasers named
therein (the "Purchasers").  A copy of the Registration Rights Agreement has
been sent to each of the Purchasers.  All capitalized terms not otherwise
defined herein shall have the meanings ascribed thereto in the Registration
Rights Agreement.

     In order to have Registrable Securities included in the Shelf Registration
Statement (or a supplement or amendment thereto), this Notice of Registration
Statement and Selling Securityholder Questionnaire ("Notice and Questionnaire")
must be completed, executed and delivered to the Company at the address set
forth herein for receipt ON OR BEFORE [insert date that is 25 days from the
Notice date] (the "Questionnaire Deadline").  Unless the Company otherwise
consents, beneficial owners of the Registrable Securities who do not complete,
execute and return this Notice and Questionnaire by such date (i) will not be
named as selling securityholders in the Shelf Registration Statement (or a
supplement or amendment thereto) and related Prospectus and (ii) may not sell
their Registrable Securities pursuant thereto.  Beneficial owners of Registrable
Securities not who have returned a Notice and Questionnaire by the Questionnaire
Deadline may, however, receive another Notice and Questionnaire from the Company
upon request.  Following its receipt of a completed and signed Notice and
Questionnaire, the Company will include the Registrable Securities covered
thereby in the Shelf Registration Statement subject to restrictions on the
timing and number of supplements to the Shelf Registration Statement provided in
the Registration Rights Agreement.

     Certain legal consequences arise from being named as a selling
securityholder in the Shelf Registration Statement and related Prospectus.
Accordingly, holders and beneficial owners of Registrable Securities are advised
to consult their own securities law counsel regarding the consequences of being
named or not being named as a selling securityholder in the Shelf Registration
Statement and related Prospectus.

     The term "Registrable Securities" is defined in the Registration Rights
Agreement to mean all or any portion of the Notes issued under the Trust
Indenture and the Common Stock issuable upon conversion of such Notes, provided,
however, that a security ceases to be a Registrable Security when it is no
longer a Restricted Security.
<PAGE>

     The term "Restricted Security" is defined in the Registration Rights
Agreement to mean any Note or Common Stock issuable upon conversion thereof
except any such Note or Common Stock which (i) has been registered pursuant to
an effective registration statement under the Securities Act and sold in a
manner contemplated by the Shelf Registration Statement, (ii) has been
transferred in compliance with Rule 144 under the Securities Act (or any
successor provision thereto) or is transferable pursuant to paragraph (k) of
Rule 144 (or any successor provision thereto) or (iii) has otherwise been
transferred and a new Note or share of Common Stock not subject to transfer
restrictions under the Securities Act has been delivered by or on behalf of the
Company in accordance with the Indenture.

                                    ELECTION

     The undersigned holder (the "Selling Securityholder") of Registrable
Securities hereby elects to include in the Shelf Registration Statement the
Registrable Securities beneficially owned by it and listed below in Item (3)
(unless otherwise specified under Item 3).  The undersigned, by signing and
returning this Notice and Questionnaire, agrees to be bound with respect to such
Registrable Securities by the terms and conditions of this Notice and
Questionnaire and the Registration Rights Agreement, including, without
limitation, Section 5 of the Registration Rights Agreement, as if the
undersigned Selling Securityholder were an original party thereto.

     Upon any sale of Registrable Securities pursuant to the Shelf Registration
Statement, the Selling Securityholder will be required to deliver to the Company
and the Trustee the Notice of Transfer (completed and signed) set forth in
Exhibit 1 attached to this Notice and Questionnaire and hereby undertakes to do
so.

     The Selling Securityholder hereby provides the following information to the
Company and represents and warrants that such information is accurate and
complete:
<PAGE>

                                 QUESTIONNAIRE

(1)  (a)  Full Legal Name of Selling Securityholder.

          ______________________________________________________________________

     (b)  Full Legal Name of Registered Holder (if not the same as in (a) above)
          of Registrable Securities Listed in (3) Below:
          ______________________________________________________________________

     (c)  Full Legal Name of Registered Holder (if applicable and if not the
          same as (b) above) Through Which Registrable Securities Listed in (3)
          Below are Held:
          ______________________________________________________________________

(2)  Address for Notices to Selling Securityholder:
     ___________________________________________________________________________
     ___________________________________________________________________________
     ___________________________________________________________________________
     Telephone:_________________________________________________________________

     Fax:_______________________________________________________________________

     Contact:___________________________________________________________________

(3)  Beneficial Ownership of Registrable Securities:

     Except as set forth below, the undesigned Selling Securityholder does not
     beneficially own any Notes or Common Stock previously issued upon
     conversion, repurchase or redemption of any Note.

     Principal amount of Notes beneficially owned:______________________________

     Number of shares of Common Stock beneficially owned and issued to date upon
     conversion, repurchase or redemption of Notes (if any):____________________

     Principal amount of Notes which the undersigned wishes to be included in
     the Shelf Registration Statement:__________________________________________

     Number of shares of Common Stock (if any) issued upon conversion,
     repurchase or redemption of Registrable Securities which are to be included
     in the Shelf Registration Statement:

     ___________________________________________________________________________

(4)  Other shares of Common Stock or other Notes of the Company owned by the
     Selling Securityholder:____________________________________________________

<PAGE>

     Except as set forth below, and under item (3) above, the undersigned
     Selling Securityholder is not the beneficial or registered owner of any
     shares of Common Stock or any other securities of the Company.

State any exceptions here:

(5)  Relationships with the Company:

     Except as set forth below, neither the Selling Securityholder nor any of
     its affiliates, officers, director or principal equity holders (5% or more)
     has held any position or office or has had any other material relationship
     with the Company (or its predecessors or affiliates) during the past three
     years.

State any exceptions here:

(6)  Plan of Distribution:

     Except as set forth below, the undersigned Selling Securityholder intends
     to distribute the Registrable Securities listed above in Item (3) only as
     follows (if at all): Such Registrable Securities may be sold from time to
     time directly by the undersigned Selling Securityholder or, alternatively,
     through underwriters, broker-dealers or agents.  Such Registrable
     Securities may be sold in one or more transactions at fixed prices, at
     prevailing market prices at the time of sale, at varying prices determined
     at the time of sale, or at negotiated prices.  Such sales may be effected
     in transactions (which may involve crosses or block transactions) (i) on
     any national securities exchanges or U.S. inter-dealer quotation system of
     a registered national securities association on which the Registrable
     Securities may be listed or quoted at the time of sale, (ii) in the over-
     the-counter market, (iii) in transactions otherwise than on such exchanges
     or services or in the over-the-counter market, or (iv) through the writing
     of options.  In connection with sales of the Registrable Securities or
     otherwise, the Selling Securityholder may enter into hedging transactions
     with broker-dealers, which may in turn engage in short sales of the
     Registrable Securities in the course of hedging the positions they assume.
     The Selling Securityholders may also sell Registrable Securities short and
     deliver Registrable Securities to close out such short positions, or loan
     or pledge Registrable Securities to broker-dealers that in turn may sell
     such securities.

State any exceptions here:

                                      -2-

<PAGE>

     Note:  In no event may such method(s) of distribution take the form of an
underwritten offering of the Registrable Securities without the prior agreement
of the Company.

     By signing below, the Selling Securityholder acknowledges that it
understands its obligation to comply, and agrees that it will comply, with the
prospectus delivery and other provisions of the Securities Act and Exchange Act
and the respective rules and regulations thereunder, particularly Regulation M.

     In the event that the Selling Securityholder transfers all or any portion
of the Registrable Securities listed in Item (3) above after the date on which
such information is provided to the Company, the Selling Securityholder agrees
to notify the transferee(s) at the time of the transfer of its rights and
obligations under this Notice and Questionnaire and the Registration Rights
Agreement.

     By signing below, the Selling Securityholder consents to the disclosure of
the information contained herein in its answers to Items (1) through (6) above
and the inclusion of such information in the Shelf Registration Statement and
related Prospectus.  The Selling Securityholder understands that such
information will be relied upon by the Company in connection with the
preparation of the Shelf Registration Statement and related Prospectus.

     In accordance with the Selling Securityholder's obligation under the
Registration Rights Agreement to provide such information as may be required by
law for inclusion in the Shelf Registration Statement, the Selling
Securityholder agrees to promptly notify the Company of any inaccuracies or
changes in the information provided herein which may occur subsequent to the
date hereof at any time while the Shelf Registration Statement remains in
effect.  All notices hereunder and pursuant to the Registration Rights Agreement
shall be made in writing by hand delivery, first-class mail, or air courier
guaranteeing overnight delivery as follows:

     To the Company:

          COR Therapeutics, Inc.
          256 East Grand Avenue
          South San Francisco, California 94080
          Attention: General Counsel

     Once this Notice and Questionnaire is executed by the Selling
Securityholder and received by the Company, the terms of this Notice and
Questionnaire, and the representations and warranties contained herein, shall be
binding on, shall inure to the benefit of and shall be enforceable by the
respective successors, heirs, personal representatives, and assigns of the
Company and the Selling Securityholder with respect to the Registrable
Securities beneficially owned by such Selling Securityholder and listed in Item
(3) above.  This Agreement shall be governed in all respects by the laws of the
State of New York.

                                      -3-
<PAGE>

     IN WITNESS WHEREOF, the undersigned, by authority duly given, has caused
this Notice and Questionnaire to be executed and delivered either in person or
by its duly authorized agent.

Dated:_________________________________________

      _________________________________________
      Selling Securityholder
      (Print/type full legal name of beneficial
      owner of Registrable Securities)

      By: _______________________________

      Name:______________________________

      Title:_____________________________

                                      -4-
<PAGE>

     PLEASE RETURN THE COMPLETED AND EXECUTED NOTICE AND QUESTIONNAIRE FOR
RECEIPT ON OR BEFORE [DEADLINE FOR RESPONSE] TO THE COMPANY AT:

          COR Therapeutics, Inc.
          256 East Grand Avenue
          South San Francisco, California  94080
          Attention: General Counsel
<PAGE>

                                                                       EXHIBIT 1
                                                                   to Appendix A

             NOTICE TO TRANSFER PURSUANT TO REGISTRATION STATEMENT

Firstar Bank, N.A.
101 E. 5th Street
12th Floor Corporate Trust
St. Paul, MN  55101

COR Therapeutics, Inc.
256 East Grand Avenue
South San Francisco, California  94080
Attention:  General Counsel

Re:      4.50% Convertible Senior Notes due June 15, 2006 (the "Notes")

Dear Sirs:

     Please be advised that                                     has transferred
$      aggregate principal amount of the above-referenced Notes or shares of the
Company's Common Stock, issued on conversion, repurchase or redemption of Notes,
pursuant to the Registration Statement Form S-3 (File No. 333-    ) filed by the
Company.

     We hereby certify that the prospectus delivery requirements, if any, of the
Securities Act of 1933, as amended, have been satisfied with respect to the
transfer described above and that the above-named beneficial owner of the Notes
or Common Stock is named as a selling securityholder in the Prospectus dated or
in amendments or supplements thereto, and that the aggregate principal amount of
the Notes or number of Common Stock transferred are [a portion of] the Notes or
Common Stock listed in such Prospectus as amended or supplemented opposite such
owner's name.
<PAGE>

Dated: _______________________________  Very truly yours,

                              _________________________________________
                                             (Name)

                              By:______________________________________
                                         (Authorized Signature)