Exhibit 31

CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER 
PURSUANT TO RULES 13a-14(a) AND 15d-14(a) OF
THE SECURITIES EXCHANGE ACT OF 1934

I, Thomas L. Wegman, certify that:

|1. | I have reviewed this report on Form 10-Q for the quarterly period ended September 30, 2009 of BioSpecifics Technologies Corp.;                                                                                                                                                                                                       
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|2. | Based on my knowledge, the report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were
made, not misleading with respect to the period covered by this report;                            
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|3. | Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as
of, and for, the periods presented in this report;                                              
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|4. | The registrants other certifying officers and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over
financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
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|5. | The registrants other certifying officers and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrants auditors and to the audit committee of the
registrants board of directors (or persons performing the equivalent functions):                                  

(a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrants ability to record, process, summarize and report
financial information; and

(b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrants internal controls over financial reporting.

Date: November 6, 2009

/s/ Thomas L. Wegman_______________________ Thomas L. Wegman 
President, Principal Executive Officer and Principal Financial Officer

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