EX-10.6



 Exhibit 10.6 

SECOND ADDENDUM 
 TO THE
RESEARCH AND LICENSE AGREEMENT 
 This Second Addendum to Research and License Agreement (the “Second Addendum”) is made by and between
The Technion Research & Development Foundation Ltd. (“TRDF”) and Eloxx Pharmaceuticals Ltd. (“Licensee” or “Eloxx”). 

WHEREAS, TRDF and Eloxx are parties to Research and License Agreement with an effective date of August
29th, 2013 (the “License Agreement”), as amended on November 26, 2013, January 14, 2014, June 9, 2014 and August 3, 2014 (collectively, the
“Agreement”); and 
 WHEREAS, the parties desire to continue the relationship contemplated by the Agreement and to further amend the
Agreement as set forth herein; 
 Now, THEREFORE, the parties hereby agree as follows: 

 

	1.	Unless otherwise defined herein, capitalized terms used in this Second Addendum shall have the meanings assigned thereto in the Agreement. 


 

	2.	The Parties agree to add those certain patents and patent applications described in Exhibit A(3) attached hereto, to Exhibits A(1) and A(2) of the Agreement. 


 

	3.	Except as added herein, all other terms and conditions of the Agreement shall remain in full force and effect, as relevant to this Second Addendum. 


 

	4.	This Second Addendum may be executed in counterparts, each of which shall be deemed an original and all of which together shall constitute one and the same instrument. Any signature page delivered by facsimile or
electronic image transmission shall be binding to the same extent as an original signature page. 

 IN
WITNESS WHEREOF, the parties hereby accept and agree to the terms and conditions of this First Addendum. 
  

													
	ELOXX PHARMACEUTICALS LTD.	  		  		  		  	THE TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.


													
							
	By:	 	 /s/ Shmuel Tuvia
	  		  		  		  	By:	 	 /s/ Benjamin Soffer

	Name:	 	Shmuel Tuvia	  		  		  		  	Name:	 	Benjamin Soffer
	Title:	 	COO	  		  		  		  	Title:	 	Technology Transfer Office, Manager
	Date:	 	Jan. 21, 2015	  		  		  		  	Date:	 	








 Exhibit A(3) 
  

															
	USE OF AMINOGLYCOSIDE ANALOGS IN THE TREATMENT OF RETT SYNDROME
								
	Our
Ref
Client
Ref	 	Country	 	Earliest
Priority	 	Entry
Date	 	Filing Date
Application No.	 	Issue Date
Patent No.	 	Status	 	Assignee
								
	59529
?	 	USA
PRO	 		 		 	05-Jun-2014
62/006,028	 		 	Filed	 	Technion Research &
Development Foundation
Limited ; Eloxx
Pharmaceuticals Ltd.









																															
	 PatentNum
	  	PatentName	  	PatentStatus
Desc	  	ApplicationDate	 	  	ApplicationNum	 	  	CountryDesc	  	Patent
Date	 	  	PatentNo	 	  	PublicationDate	 	  	PublicationNum	 
	 0816
	  	NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS	  	NP from PCT	  				  				  	N/A	  				  				  				  			
										
	 0816-00
	  	REDESIGN OF AMINOGLYCOSIDES FOR TREATMENT OF HUMAN GENETIC DISEASES CAUSED BY PREMATURE STOP MUTATIONS	  	Expired	  	 	03/04/2006	 	  	 	60/788,070	 	  	United States	  				  				  				  			
										
	 0816-01
	  	NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS	  	Expired	  	 	10/04/2007	 	  	 	PCT/IL/2007/000463	 	  	PCT	  				  				  	 	11/10/2007	 	  	 	WO 2007/113841	 
										
	 0819-02
	  	NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS	  	Filed	  	 	25/09/2008	 	  	 	194370	 	  	Israel	  				  				  				  			
										
	 0816-03
	  	NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS	  	Filed	  	 	25/09/2008	 	  	 	2,646,407	 	  	Canada	  				  				  				  			
										
	 0816-04
	  	NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS	  	Filed	  	 	10/04/2007	 	  	 	07736203.6	 	  	Europe	  				  				  				  			
										
	 0816-05
	  	NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS	  	Filed	  	 	03/10/2008	 	  	 	2009-503741	 	  	Japan	  				  				  	 	10/09/2009	 	  	 	2009-532461	 
										
	 0816-06
	  	NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS	  	Filed	  	 	01/10/2008	 	  	 	12/285,299	 	  	United Slates	  				  				  				  			
										
	 0816-07
	  	NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS	  	Filed	  	 	31/10/2008	 	  	 	09136/DELNP/2006	 	  	India	  				  				  				  			
										
	 0816-08
	  	NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS	  	Filed	  	 	10/04/2007	 	  	 	11173958.7	 	  	Europe	  				  				  	 	30/11/2011	 	  	 	2390255	 









																															
	PatentNum	  	PatentName	  	PatentStatusDesc	  	Application
Date	 	  	ApplicationNum	 	  	CountryDesc	  	PatentDate	 	  	PatentNo	 	  	PublicationDate	 	  	PublicationNum	 
	 1302
	  	REPAIRING FAULTY GENES BY AMINOGLYCOSIDES: IDENTIFICATION OF NEW PHARMACOPHORE WITH ENHANCED SUPPRESSION OF DI	  	NP from PCT	  				  				  	N/A	  				  				  				  			
										
	 1302-00
	  	REPAIRING FAULTY GENES BY AMINOGLYCOSIDES: IDENTIFICATION OF NEW PHARMACOPHORE WITH ENHANCED SUPPRESSION OF DI	  	Expired	  	 	18/11/2010	 	  	 	61/414,956	 	  	United States	  				  				  				  			
										
	 1302-01
	  	AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS	  	Expired	  	 	17/11/2011	 	  	 	PCT/IL/2011/000889	 	  	PCT	  				  				  	 	24/05/2012	 	  	 	WO2012/066546	 
										
	 1302-02
	  	AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS	  	Filed	  	 	16/05/2013	 	  	 	13/885,715	 	  	United States	  				  				  				  			
										
	 1302-03
	  	AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS	  	Filed	  	 	17/11/2011	 	  	 	11799501.9	 	  	Europe	  				  				  				  			
										
	 1302-04
	  	AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS	  	Filed	  	 	20/05/2013	 	  				  	Japan	  				  				  				  			
										
	 1302-05
	  	AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS	  	Filed	  	 	02/05/2013	 	  	 	2,816,789	 	  	Canada	  				  				  				  			
										
	 1302-06
	  	AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS	  	Filed	  	 	07/05/2013	 	  	 	876/MUMNP/2013	 	  	India	  				  				  				  			
										
	 1302-07
	  	AMINOGLYCOSIDES AND USES THEREOF IN TREATING GENETIC DISORDERS	  	Filed	  	 	16/05/2013	 	  	 	226390	 	  	Israel	  				  				  				  	 	.