Exhibit 31

CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER

PURSUANT TO RULES 13a-14(a) AND 15d-14(a) OF
THE SECURITIES EXCHANGE ACT OF
1934

I, Thomas L. Wegman, certify that:

|1. | I have reviewed this report on Form 10-Q for
      the quarterly period ended March 31, 2009 of BioSpecifics Technologies
      Corp.;                                                                                                                                                                                                                         
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|2. | Based on my knowledge, the report does not
      contain any untrue statement of a material fact or omit to state a
      material fact necessary to make the statements made, in light of the
      circumstances under which such statements were made, not misleading with
      respect to the period covered by this report;                              
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|3. | Based on my knowledge, the financial
      statements, and other financial information included in this report,
      fairly present in all material respects the financial condition, results
      of operations and cash flows of the registrant as of, and for, the periods
      presented in this report;                                                
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|4. | The registrants other certifying officers
      and I are responsible for establishing and maintaining disclosure controls
      and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e))
      and internal control over financial reporting (as defined in Exchange Act
      Rules 13a-15(f) and 15d-15(f)) for the registrant and
  have:
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|   | (b)                                                                                                                                                                                                                                                                                                                                                            
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|   | (d)                                                                                                                                                                                                                                                                                                                                                            
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|5. | The registrants other certifying officers
      and I have disclosed, based on our most recent evaluation of internal
      control over financial reporting, to the registrants auditors and to the
      audit committee of the registrants board of directors (or persons
      performing the equivalent functions):                                    
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|   | (a)                                                                                                                                                                                                                                                                                                                                                            
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|   | (b)                                                                                                                                                                                                                                                                                                                                                            

Date: May 12, 2009

/s/ Thomas L. Wegman_______________________ Thomas L. Wegman

President, Principal Executive Officer and Principal Financial Officer

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