EPA Registration 264‐380  

Vol.2
1

Material to be added to an e-Jacket/Jacket 

Reg. No. 

Description: DH'-1"1I.-.?''i 

1. 0 Placement within the e-Jacket/jacket: 

p-Default: (chronological, top = newest) 

o File Location: (PDF page number, i.e., "before page 

45") 

2. 0 Send to Data Extraction contractors this material: 

o Newly stamped accepted label 

y Notification 

o NewCSF 

o Other: ____________ _ 

3. Attach this coversheet to the top of the material or jacket. It 

must be well organized and clipped together, NOT STAPLED. 

Then give the material with this coversheet to staff in the 

Information Services Center (Room S-4900). 

Reviewe r' s N arne: _--,D,-,,-__ Q.L!.,,-,",,~,-,,:0>.L~.L~=-:" _____ _ 

Phon e: _-=3_",-'.-':;'-_-=oC"-dJl-=-,-O __ Divis ion: F BJ P, D 

Date: __ ~&==~~~~ __________________ __ 

Created August 19,2008 
2

PPIS Deficiency Notice 

PM NUMBER: 22-- REGISTRATION NUMBER: U'-/ 

Transferred from: Senedu Alemu (Macfadden) Date Processed: _-,,25,-/f--I2-+1 ,-'1,-_ 

This jacket has been found to be deficient according to established EPA data processing 

guidelines for the following reasons: 

I. 

3. 

CUrrent accepted label dated __ I __ I· __ _ 

__ is missing from the jacket. __ is missing acceptance stamp. 

__ Acceptance stamp is missing date and/or registration number. 

_ Is missing the following infonnation: ______________ _ 

Acceptance letter dated l.JJlJ '\ and associated label are inconsistent 

concerning: __ Acceptance date. ')l-Product name. _ Registration number. 

Comments letter associated with label dated __ I __ I ___ is missing from thejacket. 

4. Accepted (Basic 1 Alternate) CSF dated __ 1 __ 1 __ _ 

_ Is missing from the jacket. __ Is misfiled'or has wrong registration number. 

_ Sole active ingredient source product has been cancelled. 

5. _ Active and inert chemical percentages do not equal 100%. 

o _ Other infonnation missing /~within'the jacket. See below for details. 

Ple«,<.. ~"'7 EPA .!llk'h"Q{"'" c{"Je,,L S/II('" R-~,t Nme 0(\ 
3

UNITED STATES ENVIRONMENTAL PROTECIION AGENCY 

WASHINGTON, DC 20460 

Bayer CropScience 

Laura Phelps 

2 T.W. Alexander Drive 

RTP, NC 27709 

Subject: ETHREL brand Ethephon Plant Growth Regulator 

Registration No,: 264~257 

Date Submitted: 3/14/11 

Decision No.: 447178 

PREP brand Ethcphon Plant Regulator for Cotton 

Registration No.: 264-380 

Date Submitted: 3/14111 

Decision No.: 447179 

PREP brand Ethephon for Cotton and Tobacco 

Registration No.: 264-418 

Date Submitted: 3114/11 

Decision No.: 447180 

CERONE brand Ethephon Plant Regulator 

Registration No.: 264-377 

Date Submitted: 3/14/11 

Decision No.: 447181 

Dear Ms. Phelps: 

OFFICE OF 

CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

MAY 1 1 2011 

The Agency is in receipt of your Applications for Pestictde Notification under Pesticide Registration 

Notice (PRN) 98-10. The R~gistration Division (RD) ,has conducted a review of this request for its 

applicability under PRN 98-10 and finds that the actions requested fall within the scope of PRN 98-

10. 

The Agency acknowledges the removal of the patent number from the label. 

The label submitted with the application has been stamped "Notification" and will be placed in our 

records. If you have questions concerning this letter, please contact Dominic Schuler at 703-347-0260 or 

via email at schuler.dominic@epa.gov. 

Sincerely, 

~"VVVA Tony Kish 

Product Mana er 22 

Fungicide Branch 

Registration Division (7504P) 
4

Pf.'~" "'ed b t ot':titJ". on '" • b fo,. m ; 

S}?'i l '13 3 PdntForm 

Jl.gJ"'~~i!!!o. ________ ....!Fo:2!l~lW'~P~'~"~v~.~'~. ( JN~o",.jg 2027110-00;!l!~'~0t.,.':::=;;;;;;;;;;=;;;;;:!......, 

&EPA 

1. Company/Product NUmber 

264-380 

United Stateo 

Environmental Protection Agency 

Washington, DC 20460 

~ Registration 

Amendment 

x Other 

OPP Identifier Number 

Application for Pesticide ~ Section I 

2. EPA Product Menager 

Mr. Tony Kish 

3. Propoeed Cle .. ification 

o Non. 0 Re.tricted 4. CompenylProduct (Name) 

PREP brand Ethephon Plant Regulatorfor Cotton 

PM' 

22 

5. Name and Addre •• of Appficent (Include ZIP C1dll/ 

Bayer CropScience LP 

P. O. Box 12014; 2 T. W. Alexander Dr. 

Research Trianqle Park, NC 27709 

6. Expedited Review. In accordance with FIFRA Section 3(cH3! 

(blli!, my product is similar or Identical in composition and labeling 

to: 

o EPA Reg. No. ______________ _ 

o Chllck if this is II nllw "ddf(J$$ Product Name 

o 

o 

o 

Section ~ II 

Amendment - Explain below. 

Resubmlsaion In r88pon" to Agency lettar deted ______ _ 

Notification - Explain below. 

o 

o 

o 

Explanation: u .. eddltlonal pogal.llf naceSlary. IFor section I and Section II.) 

Anal printed labela in raspon.e to 

Agency lener dated 

~Me Too~ Appllcetion. 

Othar - EXplain below. 

BayerCropScience is submitting a notification for PREP brand Ethephon plant Regulatorfor Cotton to remove the patent number from 

the label. 

Section - III 

1. Meterial Thill Product Will Be Packaged In: 

Child·Rosistent packoging Unit Packaging Wetar Solubla Packaging 

BV .. -

No BV .. No E3 V" 

No 

e CsrtifTclltion must 

btl submifttHJ 

If ~Y .. ~ No. per If ·Yos~ , Unit Packeging wgt. container Package wgt 

3. Locotion of Net Content. Infonnstion 

o Labal o Containar 

6. Mannar in Which Labal ie Affixed to Product 

4. Sito/s) Retoll Containar 

Uthograph 

Paper aluad 

Steneifed 

I 

Section - IV 

No. per containor 

2. Type of Conainer 

~::=o Gle .. 

Paper 

Othor (Spslif:~'~,: .:' _____ _ 

5. Locotlon of Label Diractlan. ' '" 

E3 On Lobel " 'c 

On Labtlr.III~~2ompenVing'product 

1. Contact Point (Complete items directly bfllow for identificstion of individual ro ba contacted, if naC6ssary, ro p':o'C~ thi$ .pp.licariop./ ,,~~~~~ 

Title 

Reg. Affairs Specialist 

N_ Telaphona Na'. /lncluda Arso Cade) 

Laura Phelps 

Certification 

I certify thet the statements I have made on this form and all attachments th8lato are true, accurate and complete. 

I ecknowledge that eny knowingly 101 .. or misleeding lltetement mey ba puniehable by fine or imprisonmant or 

both under applicable lew. 

8. Oate Applicotion 

Receivad 

(Stamped) 

4. TYPed Name 

Laura Phelps 

EPA Form 8570-1 /R.v. 8-941 PreVIous editions are obsolata. 

3. Title 

Regulatory Affairs Specialist 

March 14,2011 

Whtte • EPA FUll Copy /origlnal) Vellow • Appllc.nt Copy 
5

Bayer Crop Science 

March 10,2011 

Document Processing Desk (NOTIF) 

Registration Division (7505P) 

Office of Pesticide Programs 

U.S. Environmental Protection Agency 

One Potomac Yard (South Building) 

2777 S. Crystal Drive 

Arlington, VA 22202 

Mr. Tony Kish, RD Team 22 

( 

Subject: PREP brand Ethephon Plant Regulator for Cotton, No. 264-

380; Removal of Patent Number 

Dear Mr. Kish: 

Bayer CropScience is submitting a notification for PREP brand Ethephon 

Plant Regulator for Cotton to remove the patent number from the label. 

This notification is consistent with the provisions of"PR Notice 98 w I O. No 

other"changes have been made to -the labeling or the Confidential Statement of 

Formula for this product. I understand that it is a violation of 18 U.S.c. 

8 ... ~ 

A .. 

.. E 

c-R 

Bayer CropScience 

P. O. Box 12014 

2. T. W. Alexander Drive 

Research Tr'langle Park, NC 27709 

,,-, , 

. . • _ C ,< 

Section 1001 to willfully make any false statement to EPA. I further : (' '" 

understand that if the amended label is not consistent with the requirements of ( 

40 CFR §§ 156.1 0, 156.140, 156.144, 156.146 and 156.156, this product may" • ::. 

be in violation ofFIFRA and I may be subjected to enforcement action and eeL <- '-

• 

. , 

. penalties under Section 12 and 14 ofFIFRA". " ~ " 

Enclosed are an EPA Form 8570-1 and one copy of the revised PREP brand 

Ethephon Plant Regulator for Cotton label for review. 

Please contact me if you should have further questions. 

Sincerely, 

• , " " , 
6

( 

Bayer CropScience 

Laura Phelps 

Regulatory Affairs, Herbicides & PGRs 

Bayer CropScience 

2 T. W. Alexander Drive 

RTP, NC 27709 

office: 919-549-2302 

mobil:919-352-8075 

email: laura.phelps@bayer.com 

( 

, " 

'" , 

, , , ,c 'c 

( , ( , , , ," , c 

" , , " , , 

, , 
7

PREPTM brand Ethephon 

PLANT REGULATOR FOR COTTON 

FOR COMMERCIAL USE OR AGRICULTURAL USE ONLY. 

NOT FOR RESIDENTIAL USE. 

ACTIVE INGREDIENT: 

NOTIFICATION 

MAY i 1 iOl1 

Ethephon (2-chloroethyl) phosphonic acid* .... ····· ........................ ······.· .. n ••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• 39.9% 

INERT INGREDIENTS: ........................................................................................................................................................ 60.1 % 

*This product contains 4 pounds ethephon per galion. 

EPA Reg. No. 264-380 EPA Est. No. 264-PA-Ol 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

Si usted no entiende la etiqueta, busque a alguien para que se la explique a usted en detalle. 

(If you do not understand the label, find someone to explain it to you in detail.) 

For MEDICAL And TRANSPORTATION Emergencies ONLY Call 24 Hours A Day IM800M334-7S77 

For PRODUcr USE Information Call IM866M99BA YER (l-866M992-2937) 

FIRST AID 

IF IN EYES: • Hold eye open and rinse slowly and gently with water tor 15-20 minutes. 

• Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. 

• Call a poison control center or doctor for treatment advice. 

IF ON SKlN OR • Take olf contaminated clothing. 

CLOTHING: 

• Rinse skin immediately with plenty of water for 15-20 minutes. 

• Call a poison control center or doctor for treatment advice. 

IF SWALLOWED: • Immediately call a poison control center or doctor for treatment advice. 

• Do not induce vomiting unless told to do so by a poison control center or doctor. 

• Have person· sip a glass of water if able to ·swallow. 

• Do not Qive anythina by mouth to an unconscious person. 

For MEDICAL Emergencies Call 24-Jlours A Day IM800-334-7S77. 

Have the nroduct container or tabet with vou when callin a Doison control center or doctor or .:::oin6 f"r treat'!!!!!!:. 

NOTE TO PHYSICIAN: Treat symptomatically. Consideration should be given to the possibility thrJ cv~~cxposu~e to materials 

other than this product may have occurred. No specific antidote is available. Probable mucosal damage m"l~' contraindb::tts the use 

of gastric lavage. 

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

Corrosive. Causes irreversible eye damage and skin irritation. Harmful if swallowed or absorbed through skin. Do not get in eyes, on 

skin, or on clothing. 

Harmful or fatal if swallowed. Avoid contamination of food. 
8

PERSONAL PROTECTIVE EQUIPMENT (PPE) 

Applicators and other handlers must wear long-sleeved shirt and long pants, chemical resistant gloves made of any waterproof material 

(such as Nitrile, Butyl, Neoprene and/or Barrier laminate), shoes plus socks and protective eyewear. 

When handlers use closed systems, enclosed cabs, or aircraft in a manner that meets the requirements listed in the Worker Protection 

Standard (WPS) for agricultural pesticides [40 CFA 170.240 (d) (4-6)]. the handler PPE requirements may be reduced or mooified as 

specified in the WPS. 

Discard clothing and other absorbent materials that have been drenched or heavily contaminated with this producfs concentrate. Do 

not reuse them. Follow manufacturer's instructions for cleaningfmaintaining PPE. If no such instructions for wash ables, use detergent 

and hot water. Keep and wash PPE separately from other laundry. 

User Safety Recommendations 

Users should wash hands before eating, drinking, chewing gum, using tobacco or using the toilet 

Users should remove clothing immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing. 

Users should remove PPE immediately after handling this product As soon as possible, wash thoroughly and change into clean 

clothing. Wash the outside ai-doves before removina. 

ENVIRONMENTAL HAZARD 

Avoid spray drift to nearby crops as this product may cause temporary modifications in plant growth. Do not contaminate water used for 

irrigation or domestic purposes. 

Do not apply directly to water, or to areas where surface water is present or to intertidal areas below the mean high water mark. Do not 

contaminate water when disposing of equIpment washwaters. 

Do not exceed the rate of PREpTM brand Ethephon Plant Regulator for Cotton per acre per year recommended on this label. 

SPRAY DRIFT 

Avoid spray drift. Do not apply when weather conditions may cause drift. Do not allow this product to drift on to non~target areas. Drift 

may result in illegal residues or injury to adjacent crops and vegetation, in the form of leaf yellowing and defoliation. To avoid spray 

drift, DO NOT apply aerially when wind speed is greater than to mph or during periods of temperature inversions. Use of larger droplet 

size will also reduce spray drift. 

AVOIDING SPRAY DRIFT ATTHE APPLICATION SITE IS THE RESPONSIBILITY OF THE APPLICATOR. 

The interaction of many equipment~and~weather"related factors determine the potential for spray drift. The applicator is responsible for 

considering all these factors when making decisions. 

The following drift management reqUirements must be followed to avoid off~target movement from aerial applications to agricultural field 

crops. These requirements do not apply to forestry applications, public health uses or to applications using dry formulations. 

1. The dlstance of the outer most nozzles on the boom must not exceed 3{4 the length of the wingspan or rotor. 

2. Nozzles must always point backward parallel with the air stream and never be pointed downwards more than 45 O(>~TAPS. 

Where states have more stringent regulations" they should be observed. 

The applicator should be familiar with and take into account the information covered in the Aerial Drift Reduction Advisory below: 

AERIAL DRIFT REDUCTION ADVISORY 

[This section is adviSOry In nature and does not supersede the mandatory label requirements]. 

INFORMATION ON DROPLET SIZE 

The most effective way to reduce drift potential is to apply large droplets. The best drift management ~*"'t-<;!gy is to aprly the largest 

droplets that provide sufficient coverage and control. Applying larger droplets reduces drift potential, but wlll (lot pn'!vent drift if 

applications are made improperly, or under unfavorable environmental conditions (See Wind, Temperature a!,ti humidity, and 

Temperature Inversions). 

CONTROLLING DROPLET SIZE 

Volume - Use high flow rate nozzles to apply the highest practical spray volume. Nozzles with higher rated flows produce larger 

droplets. 

Pressure ~ Do not exceed the nozzle manufacturer's recommended pressures. For many nozzle types lower pressure produces larger 

droplets. When higher flow rates are needed, use higher flow rate nozzles instead of increasing pressure. 

Number of nozzles ~ Use the minimum number of nozzles that provide uniform coverage. 

Nozzle Orientation ~ Orienting nozzles so that the spray is released parallel to the airstream produces larger droplets than other 

orientations and is the recommended practice. SIgnificant deflection from horizontal will reduce droplet size and increase drift potential. 

2 
9

Nozzle Type ~ Use a nozzle type that is designed for the intended application. With most nozzle types, narrower spray angles produce 

larger droplets. Consider using low-drift nozzles. Solid stream nozzles oriented straight 'back produce the largest droplets and the 

lowest drift. 

BOOM LENGTH 

For some use patterns, reducing the effective boom length to less than 3/4 of the wingspan or rotor length may further reduce drift 

without reducing swath width. 

APPLICATION HEIGHT 

Applications should not be made at a height greater than 10 feet above the top of the target plants unless a greater height is required 

for aircraft safety. Making applications at the lowest height that is safe reduces exposure of droplets to evaporation and wind. 

SWATH ADJUSTMENT 

When applications are made with a crosswind, the swath will be displaced downwind. Therefore, on the up and downwind edges of the 

field, the applicator should compensate for this displacement by adjusting the path of the aircraft upwind. Swath adiustment distance 

should increase, with increasing drift potential (higher wind, smaller drops, etc.). 

WIND 

Drift potential is lowest between wind speeds of 2 - 10 mph. However, many factors, including droplet size and equipment type 

determine drift potential at any given speed. App~cation should be avo'lded below 2 mph due to variable wind direction and high 

inversion potential. NOTE: local terrain can influence wind patterns. Every applicator should be familiar with local wind patterns and 

how they affect spray drift. 

TEMPERATURE AND HUMIDITY 

When making applications in low relative humidity, set up equipment to produce larger droplets to compensate for evaporation. Droplet 

evaporation is most severe when conditions are both hot and dry. 

TEMPERATURE INVERSIONS 

Applications should not occur during a temperature inversion because drift potential is high. Temperature inversions restrict vertical air 

mixing, which causes small suspended droplets to remain in a concentrated cloud. This cloud can move in unpredictable directions due 

to the light variable winds common during inversions. Temperature inversions are characterized by increasing temperatures with 

altitude and are common on nights with limited cloud cover and light to no wind. They begin to form as the sun sets and often continue 

into the morning. Their presence can be indicated by ground fog; however, if fog is not present, inversions can also be identified by the 

movement of smoke from a ground source or an aircraft smoke generator. Smoke that layers and moves laterally in a concentrated 

cloud (under low wind conditions) indicates an inversion, while smoke that moves upward and rapidly diSSipates indicates good vertical 

air mixing. 

SENSITIVE AREAS 

The pesticide should only be applied when the potential for drift to adjaCent sensitive areas (e.g. residential areas, bodies of water, 

known habitat for threatened or endangered species, non-target crops) is minimal (e.g. when wind is blowing away from the sensitive 

areas). 

DIRECTIONS ,FOR USE 

It is a violation of Federal law to use this product in a manner inconsistent with its labeling. 

Do not appfy thIs product in a way that will contact workers or other persons, either directly or through drift. OnlY;lrotected 

handlers may be in the area during application. For any requirements specific to your State or Tribe, consult tn~ agency 

responsible for pesticide regulations. 

Read entire label before usIng this product. 

,---------cc----c:=c-----,c----------- ------, AGRICULTURAL USE REQUIREMENTS 

Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR p::.r; ; 70. This s(anda(d contains 

requirements for the protection of agricultural workers on farms, forests, nurseries, and greenhouso:;, cr,d handlers vf agricultural 

pesticides. It contains requirements for training, decontaminal'lon, notification, and emergency assistance. It alsc cont.lins specific 

instructions and exceptions pertaining to the statements on this label about personal protective equipment (PPE), noti~ication to workers 

and restricted-entry interval. The reqUirements in this box only apply to uses of this product that are covered by the 'Norkor Protection 

Standard. 

Do not enter or allow worker entry into treated areas during the restricted-entry interval (REI) of 48 hours. The REI is 72 hours in areas 

where average rainfall is less than 25 inches per year. 

PPE required for early entry to treated areas that 1s permitted under the Worker Protection Standard and that involves contact with 

anything that has been treated such as plants, soil or water is coveralls over long~sleeved shirt and long pants, chemical resistant 

gloves made of any waterproof material, such as nitrile, butyl, neoprene, or barrier laminate, chemical resistant footwear plus socks, 

and protective eyewear. For overhead exposure, chemical~resistant headgear is also required. 

Notify workers of the application by waming them orally and posting warning Signs at entrances to treated areas. 

3 
10

STORAGE AND DISPOSAL 

Do not contaminate water, food, or feed by storage or disposal. 

PESTICIDE STORAGE 

Store in a cool, dry place and away from food, feed and other pesticides. IF SPILLED: If container is broken or contents have spilled, 

follow all precautions indicated above and clean up immediately. Before cleaning up, pul on full length trousers, long sleeved shirt, 

protective gloves, and goggles or face shield. &:Iak up spill with absorbent media such as sand, earth or other suitable material and 

dispose of waste a1 an approved waste disposal facUity. 

PESTICIDE DISPOSAL 

Pesticide wastes are acutely hazardous. Improper disposal of exceSs pesticide, spray mixture, or rinsate is a violatIon of Federal law. If 

these wastes cannot be disposed of by use according to label instructions, contact your State Pesticide or Environmental Control 

Agency or the Hazardous Waste representative at the nearest EPA Regional Office for guidance. 

CONTAINER DISPOSAL 

Triple rinse (or equivalent) the empty containers. Then offer for recycling or reconditioning, or puncture and dispose of in a sanitary 

landfill, or by incineration or if allowed by state and local authorities, by burning. If container is burned, stay out of smoke. 

RETURNABLE - REFILLABLE CQNT AINERS 

After use, return the container to the point of purchase or designated locations. This container must only be refilled with PREpTM brand 

Ethephon for Cotton and Tobacco. DO NOT REUSE THE CONTAINER FOR ANY OTHER PURPOSE. Prior to refilling, inspect 

thoroughly for damage such as cracks, punctures, abrasions and damaged or worn out threads on closure devices. Do not refill or 

transport damaged or leaking containers. Check for leaks after refilling and before transportation. If the container is not being retifled, 

return it to the paint of purchase. 

GENERAL INFORMATION 

A toliar spray of PREpTM brand Ethephon Plant Regulator for Cotton will accelerate opening of mature unopened cotton bolls and 

enhance defoliation which can result in earlier harvest with an increased recoverable yield. PREpTM brand Ethephon Plant Regulator 

for,Colton treatment allows increased efficiency from a once-over harvest. 

Some premature drop at small, immature bolls may be associated with treatment. Do not apply before sufficient, mature, unopened 

bolls have developed to produce the desired yield of colton. 

A boll is mature when it is too hard to be dented when squeezed between thumb and fingers, too hard to be sliced with a sharp knife, 

and when the seed coat becomes light brown in color. 

For best results, thorough and uniform spray coverage is required. It is essential that the bolls are contacted by the spray to obtain 

optimum boll opening. Observe treated fields closely. Harvest at o~imum boll opening and defoliation, generally 14to 2t days after 

treatment. Sustained cold weather with average day and night temperatures of 65"F or lower after treatment with PREpTM brand 

Ethephon Plant Regulator for Cotton will delay the boll opening response. 

DO NOT APPLY PREpTM BRAND ETHEPHON PLANT REGULATOR FOR COTTON IF RAIN IS EXPECTED WITHIN 6 HOURS. 

Rainfall wiJhin·6 hours of application may reduce product performance. ';' 

Certified cotton seed growers should observe boll and seed maturity beJore treatment with PREpTM brand Ethephon Plant Regulator for 

Cotton. Bolls not completely mature might open with treatment of PREpTM brand Ethephon Plant Regulator for C.?1t0,1 £,iving lower 

quality seed. 

IMPORTANT: Do not apply PREpTM brand Ethephon Plant Regulator for Colton through any type of irr;gatiun .;;ystem. 

SPRAY PREPARATION 

Add 1/2 to 3/4 of the required amount of water to the spray tank. Start agitation. Add the required amount of PREpn brdntl Ethephon 

Plant Regulator for Colton, and the remaining amount of water. Prepare only as much spray solution a3 co.;, be used on the day of 

mixing. Do not allow spray solution to stand overnight. 

Do not spill the concentrated product on spray equipment, or any airplane parts. ANY SPILLS SHOULD BE RINSEG ,r.IIJlcDIATEl Y 

WITH PLENTY OF WATER. 

Use of a nurse tank is highly recommended for avoiding possible spills of concentrated formulation on spray equipmem or any airplane 

parts. 

EQUlPJ\.1ENT CLEAl~ING 

Spray deposits of PREprM brand Ethephon Plant Regulator for Cotton, when left on aircraft acrylic plastic type windshields for longer 

than 1 hour, may react with this material, forming an opaque film or spots on the surface which cannot be removed by washing with 

water or any other cleaner. Rinse windshields with water immediately after each tankload of PREpTM brand Ethephon Plant Regulator 

for Cotton has been appned. Thoroughly rinse the aircraft with clean water after each day PREpTM brand Ethephon Plant Regulator for 

Colton is applied. 

4 
11

PREpTM brand Ethephon Plant Regulator for Cotton may also affect certain paints, and if accidental deposits on painted objects such 

as cars, trucks, agricultural equipment, etc. occurs, these objects should be rinsed with water as soon as possible (within 1 hour) to 

prevent permanent staining of the painted suriace. 

Because of the acidic nature of this product, prolonged exposure to spray deposit wirr damage acrylic plastics, certain paints, and 

metals. 

Rinse thoroughly with a detergent and water all exposed acrylic plastic-type materials (e.g., aircraft windshields), and painted suriaces 

wjthjn an hour after exposure to spray deposits. At the end of each day, rinse thoroughly with a detergent and water all the metal parts 

of the aircraft and the associated spray equipment exposed to the spray deposits. 

BOLL OPENING 

CONDITIONS EXPECTED 

5-7 DAYS AFTER 

TREATMENT 

Hot and dry 80'F or higher 

Dry with temperature 

7S"Fto 80'F 

Cool but higher than 65'F 

Rank collon 

Rates For Boll Opening 

PREPTM brand Ethephon ONE GALLON OF 

Plant Regulator for Collon PREpTM brand Ethephon 

Plant Regulator for Cotton 

QUARTS/ACRE TREATS 

1.0 (1.0 Ib a.i.) 4 Acres 

t.S (1.5 Ib a.i.) 2.5 Acres 

2.0 (2.0 Ib a.i.) 2 Acres 

2.0 (2.0 Ib a.i.) 2 Acres 

SPRAY VOLUME 

GALJACRE 

GROUND AIR 

t5 to 50 

15toSO 

1St050 

25toSO 

2to 5" 

2 to 5~ 

2 to 5* 

5 

"NOTE: For California and Arizona use a volume of no less than 5 gallons per acre for aerial applications 

Time of Application (Boll Opening) 

Apply when there are sufficient mature unopened bons to produce the desired yield, but no later than when 60% of the bolls are opened 

(see General Information section on how to test for boll maturity). 00 not tank mix PREpTM brand Ethephon Plant Regulator for Cotton 

with a desiccant if the cotlon is to be spindle harvested. 

5 
12

PRECONDITIONING FOR DEFOLIATION 

Rates For Preconditioning For Defoliation 

CONDITIONS EXPECTED 

5-7 DAYS AFTER 

TREATMENT 

Hoi and dry 80'F or higher 

Cool but higherlhan 65'and 

also for rank colton 

PREpTM brand Elhephon 

Plant Regulator for Cotton 

QUARTS/ACRE 

0.5 (0.5 Ib a.i.) 

1.0 (I.O Ib a.i.) 

ONE GALLON OF 

PREpTM brand Elhephon 

Plant Regulator for Cotton 

TREATS 

8 Acres 

4 Acres 

SPRAY VOLUME 

~AI [ACRE 

GROUND AIR 

151050 2 to 5* 

151050 2105* 

*NOTE: For California and Arizona use a volume of no less than 5 gallons per acre for aerial applications. 

Time of Applieation (pr~onditioning) 

Apply PREpTM brand Elhephon Plant Regulator for Cotton 4 to 7 days prior to application of defoliant or lank mixed with the defoliant 

(see section on Compatibility). Do nollank mix PREpTM brand Ethephon Plant Regulator for Cotton with desiccants unless plant 

desiccation is required. 

Pr~treatment With Defoliants Prior to PREpTM brand Ethephon Plant Regulator for CoHon Treatment 

lithe cotton is overly rank or laying down in the middles and good spray coverage 01 the bolls with PREpTM brand Ethephon Plant 

Regulator lor Cotton is difficult, a pretreatment with defoliants will be useful to improve boll coverage with PREpTM brand Ethephon 

Plant Regulator for Cotton. Use dosage rates of PREpTM brand Ethephon Plant Regulator for Collon recommended for boll opening. 

Read and observe all appropriate label use direcnons and precautions for the defoliant used. 

Do not use a defoliant before there are sufficient mature unopened bolls to produce the desired yield (see General Information section 

on how to test for Boll Maturity). 

COMPATIBILITY 

PREpTM brand Ethephon Plant Regulator for Cotton is compatible with DEF, FOLEX, DROPP, HARVADE, METHYL PARATHION, 

GUTHION AND MALATHION, and may be applied in sequence or as a tank mixture (DO NOT TANK MIX WITH DEFOLIANTS OR 

DESICCANTS IN CALIFORNIA AND ARIZONA). In some cases slight reduction in boll opening response has been observed when 

tank mixes with deloliants were used. 

Good agitation in the spray tank is essential and a tank mixture should- not be allowed to stand without agitation for more than 5 to 10 

minutes. Read and observe all appropriate label use directions and precautions for the defoliants and insecticides used. 

PRECAUTION: 

NOTE: UNDER CERTAIN CONDITIONS, TANK MIXTURES OF PREpiM BRAND ETHEPHON PLANT REGULATOn FOR CanON 

WITH DESICCANTS CONTAINING SODIUM CHLORATE COULD RESULT IN THE FORMATION OF HYPOCHLDRC·JS ACIDS 

WHICH ON HEATING WILL EMIT TOXIC CHLORIDE FUMES. 

DO NOT MIX PREpTM BRAND ETHEPHON PLANT REGULATOR FOR COnON WITH AMMONIUlIr; Tn'O.:;ULFATE. SUCH TANK 

MIXTURES MAY RESULT IN FORMATION OF TOXIC FUMES. 

WHEN TO HARVEST: 

Do not harvest cotton sooner than 7 days after a treatment with PREpTM brand Ethephon Plant Regu!<"tor 'or Callan. Observe the 

treated crop and harvest when optimum boll opening has been reached. Too early harvest might retJuce the full advantage of the 

treatment and too late a harvest may result in reduced quality and loss of lint which will drop from the plant. 

USE LIMITATIONS 

Do not exceed a maximum at 2.0 lb. ethephon active ingredient per acre per year through combined or repe3.ted uses of any 

ethephon products. 

Boll Opening: Do not tank mix PREpTM brand Ethephon Plant Regulator for Cotton with a desiccant if the cotton is to be spindle 

harvested. 

Pre-Condition for Defoliation: Do not tank mix PREpTM brand Ethephon Plant Regulator for Cotton with desiccants unleSS plant 

desiccation is required. Do not use a defoliant before there is suflicient mature unopened bolls to produce the desired yield {see 

General Information section on how to test for boll maturity. 

Do not plant another crop within 30 days after treatment. 

6 
13

USE PRECAUTIONS 

Avoid spray drift to nearby crops as this product wj)) cause modifications in plant growth. Plant injury or reduced yields wiD result 

Mix only the amount of spray you expect to use each day. Do not allow mixed solution to stand overnight. 

IMPORTANT: READ BEFORE USE 

Read the entire Directions for Use, Conditions, Disclaimer of Warranties and Limitations of Liability before using this product. If tenns 

are not acceptable, return the unopened product container at once. 

By using this product, user or buyer accepts the following Conditions, Disclaimer of Warranties and Limitations of Liability. 

COND1TIONS: The directions for use of this product are believed to be adequate and should be followed carefully. However, it is 

impossible to eliminate all risks associated with the use of this product. Crop injury, ineffectiveness or other unintended consequences 

may result because of such factors as weather conditions, presence of other materials, or the manner of use or application, all of which 

are beyond the control of Bayer CropScience. All such risks shall be assumed by the user or buyer. 

DfSCLAIMER OF WARRANTfES: BAYER CROPSCIENCE MAKES NO OTHER WARRANTIES, EXPRESS OR IMPLIED, OF 

MERCHANTABILITY OR OF FITNESS FOR A PARTICULAR PURPOSE OR OTHERWISE, THAT EXTEND BEYOND THE 

STATEMENTS MADE ON THIS LABEL. No agent of Bayer CropScience is authorized to make any warranties beyond those contained 

herein or to modify the warranties contained herein. BAYER CROPSCIENCE DISCLAIMS ANY LIABILITY WHATSOEVER FOR 

SPECIAL, INCIDENTAL OR CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OFTHIS PRODUCT. 

lIMITATfONS OF UABILlTY: THE EXCLUSIVE REMEDY OF THE USER OR BUYER FOR ANY AND ALL LOSSES, INJURIES OR 

DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, WHETHER IN CONTRACT, WARRANTY, TORT, 

NEGLIGENCE, STRICT LIABILITY OR OTHERWISE, SHALL NOT EXCEED THE PURCHASE PRICE PAID, OR AT BAYER 

CROPSCIENCE'S ELECTION, THE REPLACEMENT OF PRODUCT. 

(.ty Bayer CropScience 

Bayer CropScience LP 

P.O. Box 12014,2 T.W. Alexander Drive 

Research Triangle Park, North Carolina 27709 

1-866-99BA YER (1-866-992-2937) 

PREpTM brand Ethephon Plant Regulator for Cotton (MASTER) Approved 11/27/02, Notification 03/14/2011 

7 
14

MATERIAL TO BE ADDED TO JACKET 

REG # 

Description: 

check all that apply 

0 new stamped accepted label ~ ::ii, 

Q" 

0 new CSF .... 

0 

W notification ~. 

C") 

Instructions: 

Attach this sheet to the top of ALL material sent to the file room (both loose paper and 

new material in jackets). This sheet will be imaged; a clear description will aid in 

finding material in the e-jacket Remove staples from all material. If returning loose 

paper then hold together with a binder or paper clip. CSFs should be placed in the 

CSF folder (if returning jacket) or covered with a red CBI sheet (if returning loose 

paper). Material to be returned to file room should be place in the appropriate bin. 

R'''=fllplZlt ~ D", :? = -/6 

Phone: .3 (2. S-- U49' s a Division: .... J.tJt..... ___ ...... 
15

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

OFFICE Of 

PREVEC'iTION, PESTICIDES Al'iD 

TOXIC SUBSTANCES 

AUG 1 9 2010 

Ms Laura Phelps 

Bayer CropScience LP 

Po Box 12014,2 T.W. Alexander Drive, 

Research Triangle Park, NC 27709 

SUBJECT: Label Notification(s) for Pesticide Registration Notice PRN 2007-4 

Request Storage and disposal changes 

EPA Reg. No. 264-380 

Application Dated July 30, 2010 

Dear Registrant: 

The Agency is in receipt of your Application for Pesticide Notification under 

Pesticide Registration Notice (PRN) 2007-4 dated 7/30/2010 for the product PREP "{ 

Brand Ethephon Plant Regulator for Cotton. The Registration Division (RD) has 

conducted a review oftrus request for its applicability under PRN 2007-4 and finds that the 

action(s) requested does not clearly fall within t,he scope ofPRN 2007-4 and will require 

additional administrative review of the related files. A summary of our findings include: 

The language used in the storage and disposal section goes beyond the scope ofPRN 

.2007-4 and this must be reviewed as an amendinent. . 

Therefore, the RD has determined that this action is denied and will be further 

processed as an amendment and our records have been updated accordingly. The label 

submitted with the application is considered proposed drafts and has been forwarded to Tony 

Kish (PM 22) for further processing. 

If you have any questions, please contact me directly at 703-305-5335 or Banza 

Djapao of my staff at 703-305-7269. 

Sincerely, 

rldJ{~~ Paul Mastradone, Acting Leader ~ 

Notifications & Minor FOlTImlations'feam Leader 

Registration Division (7505P) 

Office of Pesticide Programs 
16

ayer CropScience 

July 30, 2010 

Document Processing Desk (AMEND) 

Office o[Pesticide Program (H7504P) 

u.s. EPA, Room S4900 

One Potomac Yard 

Arlington, VA 22202 -4525 

ATTN: Mr. Tony Kish (PM 22) 

Registration Division (7505P) 

( 

8 . 

~\ \, 

8AYER 

Subject PREpTM brand Ethephon PLANT REGULATOR FOR COTTON (Reg. No.: 

264- 380): Submission of the Application of Pesticide Notification under PR Notice 

2007-4 (Ref.: the Pesticide Container and Containment Final Rule, August 16, 2006) 

Dear Mr. Kish: 

Bayer CropScience herein submits this amendment for the PREPTM brand Ethephon 

PLANT REGULATOR FOR COTTON (Reg. Nil.: 264- 380), a solution containing 

ethephon as the active ingredient. The amendmen-t is to comply with the label language 

required by the regulation in 40 CFR part 156 established by the Final Rule "Pesticide 

Management and Disposal; Standards for Pesticide Container and Containment" (August 

16,2006). Based on the Gnidance issued under the PR Notice 2007-4 and the productspecific infonnation, we propose the following "Container Disposal" labeling (see Secpoqq 

for "Storage and Disposal"): ' __ , , , 

CONTAINER DISPOSAL 

Rigid, Non-refillable containers small enough to shake (i.e., with capacities equal to or less than 5 gallons) 

Non-refillable container. Do not reuse or refill this container. Offer for recycling, if available. Triple rinse or pressure rinse 

container (or equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining contents into application 

equipment or a mix tank and drain for 10 seconds afterthe flow begins to drip. Fill the container 1f4 full with water an'f-' ~ , _ 

recap. Shake for 10 seconds. Pour rinsate into application equipment or a mix tank or store rinsate for later use or disjS6~al. ' 

Drain for to seconds after the flow begins to drip. Repeat this procedure two more times. Once container is rinsed, offer for 

recycling if available or puncture and dispose of in a sanitary landfill. 

'" ' 
17

PIe ••• ,... ". ." r.wne "'ore ~" .. to F rm ~twrov.d._ JB No. 2070-0080 ( Print Form 

UnitltCl Stllto. § Registration OPP Idontifier Number 

&EPA Environmental Protection Agency x Amendment 

W .. hington, DC 20460 Other 

Application for Pesticide - Section I 

1. ComponylProduct Number 2. EPA Product Managor 3. Propo •• d Cla.sificetion 

264-380 Mr. Tony Kish o None o Restrict6d 4. CompanylPtoduct (Nama) PM' 

PREP"'"' brand Ethephon PLANT REGULATOR FOR COTTON 22 

5. Name and Addra .. of Appllc.nt (Include ZiP CodflJ 6. Expedited Review. In accordance with FIFRA Section 31cH31 

Bayer CropScience LP Ibllil. my product Is similar or identical in composition and labeling 

P. O. Box 12014; 2 T. W. Alexander Dr. to, 

Research Trianqle Park, NC 27709 II EPA Reg. No. 

D Chtlck if thi$ i$. ntlw .ddfe&S Product Name 

Section - II 

0 Am.ndm.nt· EXplain below. D Final printed label. in r.'Pone. to 

Ag'ncy I.tter d.t.d D Re,ubml.eiion In r •• pon •• to Aglncy lener d.ted D -Mo Too· AppflC.tion. NOTIFICATlo!~ 

D Notification· Elq:Jloin b.low. D Oth.r· Elq:Jlain b.low. 

A!lr. 1 9 ?P'" 

Explanation: u •• additional page(s) if n.c •••• ry. (For .Ictlon I .nd Section II.) 

8ayerCropScience would like to add the required container disposal language to the PREP""' brand Ethephon PLANT REGULATOR FDR 

conaN (Reg. No.: 264- 380) label per PR notice 2007-4. 

Section - III 

1. Moterial nu. Product WiD Be Pockaged In: 

Child-R.aistant Packaging Unit Packaging Wat.r Soluble Peckaging 2. Typ. of Container 

~r'- @V" @ V .. §~t. X N. X N. N. 

X Plastic 

Gla .. 

a CertJlication mU3t If -V.s- No. per If -V.,· :- No. por P.p.r 

Unit P.ck'ging wgt. container Package w_gt conteiner Other (Specify) btl $ubmitttH:I 

I 

3. Locetion of Net Contents Information 4. Size(s} Rotall Contain.r 5. Locetion of label Oir.ction. 

I8J o Com-iner 2.5g or larger ~ OnLllboi 

lab_ On UbelinG eccomp.nying product 

6. Manner in Which Labol i, Affix.d to Produot K: Uthogreph U Other 

Paper ~Uitd Stenci Od --.="' Section - IV , , < C c 

1. Contact Point (CtJmpl". itlHTl$ dirtICt/y btJ/ow fOf idflntificstion of individIJs/ to ba contsct.d, if n.ceu.'Y, to ptOCNS this .,,~diwf,fiot1.J 

" , N_ Title TlJlephona No. (I[IOIOOe Ar~., ct~., 

Laura Phelps Reg. Affairs Specialist 919-549-2302 c 

Certification '. c , { , 8. Ost. Applic.tJon, 

I c.rtify that the ,tatements I heve mad. on thic form and all attet:hmonts thO/ato 8ro tl\l •• accurate and complsto. e ke~~l;'ed 

" , ," , I ecknowl.dg. that any knowingly fal .. er misleading .tatement mev b. punishable by fin. or imprisonment or ,(Stampe,d,l: , both under applicablalaw. c 

2d~~ 1P NJjJS 3. Title co "- " c 

Regulatory Affairs Specialist -" , 

c " '. 

4. Typitd Nama 5. Oat. 

Laura Phelps July30,2010 

~ ~ EPA Form 8570-1 (Rov. 8-S41 Prelllous odltlon, .ro obsolete. Whtta • EPA FlIto Copy (orIglnall VeVow • AppllcSllt copy 
18

( 

Rigid Non-refillable containers that are too large to shake (i.e., with capacities greater than 5 gallons or 50 Ibs) 

Non-refillable Containers 

Non-refillable containers - Do not reuse or refill this container. Refer to Bottom Discharge IBC or Top Discharge IBC, Drums, 

Kegs infonTIation as follows. 

Bottom Discharge IBC (e.g. - Schuetz Caged IBC or Snyder Square Stackable) 

Pressure rinsing the container before final disposal is the responsibility of the person disposing of the container. To pressure 

rinse the container before final disposal, empty the remaining contents from the IBC into application equipment or mix tank. 

Raise the bottom of the IBC by 1.5 inches on the side which is opposite of the bottom discharge valve to promote more 

complete product removal. Completely remove the top lid of the IBC. Use water pressurized to at least 40 PSI to rinse all 

interior portions. Continuously pump or drain rinsate into application equipment or rinsate collection system while pressure 

rinsing. Continue pressure rinsing for 2 minutes or until rinsate becomes clear. Replace the lid and close bottom valve. 

Top Discharge IBC, Drums, Kegs (e.g.- Snyder t20 Next Gen, Bonar B t20, Drums, Kegs). 

Triple rinsing the container before final disposal is the responsibility of the person disposing of the container. To triple rinse 

the container before final disposal, empty the remaining contents from this container into application equipment or mix tank. 

Fill the container at least 10 percent full with water. Agitate vigorously or recirculate water with the pump for 2 minutes. 

Rinse all interior surfaces. Pour or pump rinsate into application equipment or rinsate collection system. Repeat this 

procedure two more times. Once container is rinsed, offer for recycling if available or puncture and dispose of in a sanitary 

landfill. 

Refillable Containers 

Refillable container - Refer to Bottom Discharge IBC or Top Discharge IBC, Drums, Kegs infonTIation as follows. Refill this 

container with pesticide only. Do not reuse this container for any other purpose. After emptying product from container,either 

retum container to Bayer CropScience per instructions from Bayer CropScience Customer Service Center (t-800-527-4781) 

or rinse and either recycle or dispose of the container as follows: 

Bottom Discharge IBC (e.g. -Schuetz Caged IBC or Snyder Square Stackable) 

Pressure rinsing the container before final disposal is the responsibility of the person disposing of the container. Cleaning 

before refilling is the responsibility of the refiller. To pressure rinse the container before final disposal, empty the remaining 

contents from the IBC into application equipment or mix tank. Raise the bottom of the IBC by t.5 inches on the side which is 

opposite of the bottom discharge valve to promote more complete product removal. Completely remove the top lid of the 

IBC. Use water pressurized to at least 40 PSI to rinse all interior portions. Continuously pump or drain rinsate into 

application equipment or rinsate collection system while pressure rinSing. Continue pressure rinsing for 2 minutes or until 

rinsate becomes clear. Replace the lid and close bottom valve. 

Top Discharge IBC, Drums, Kegs (e.g.- Snyder 120 Next Gen, Bonar B t20, Drums, Kegs). 

Triple rinsing the container before final disposal is the responsibility of the person disposing of the container. Cleaning 

before refilling is the responsibility of the refiller. To triple rinse the containers before final disposal, empty the remaining 

contents from this container into application equipment or mix tank. Fill the container at least to percent full with water. 

Agitate vigorously or recirculate water with the pump for 2 minutes. Rinse all interior surfaces. Pour or pump rinsate into 

application equipment or rinsate collection system. Repeat this proCedure two more times. Once container is rinsed, offer for 

recycling if available or puncture and dispose of in a sanitary landfill. 

Refillable Containers 

End users are authorized to remove tamper evident cables as required to remove the product from the container unless the 

container is equipped with one way valves and refilling or retuming is planned. Ifthis is the case, end users are not 

authorized to remove tamper evident cables, one way valves or clean container. See Container Disposal instructions under 

Storage and Disposal. ( ( • C 

'" , 

Enclosed is an EPA Form 8570-1, one copy of the revised PREPTM brand Ethephon PLANi'( , ' 

REGULATOR FOR COTTON (Reg. No.: 264- 380) label for review. and an extra page (with 

the Container Disposal Section) where the revised/new text is highlighted. 

This amendment is consistent with the guidance inPRNotice 2007-4 and EPA's 

alternative language acceptance letter to Bayer CropScience dated November 10, 2009. No other 

changes have been made to the labeling or the Confidential Statement of Formula for this prQG.uct: ' 

I understand that it is a violation of 18 U.S.C. Section 1001 to willfully make any false statement to 

EPA. I further understand that if the amended label is not consistent with the requirements of4::! 

2 

, , , , • 

"( , 

" , 
19

CFR §§156.1O, 156.140, 156.144, 156.146 and 156.156, this product may be in violation ofFIFRA 

and I may be subjected to enforcement action and penalties WIder Section 12 and 14 ofFIFRA". 

Please contact me if you should have further questions. 

Sincerely, 

Laura Phelps 

Regulatory Affairs, Herbicides & PGRs 

Bayer CropScience 

2 T. W. Alexander Drive 

RTP, NC 27709 

office: 919-549-2302 

mobil:919-352-8075 

email: 1aura.phelps@bayercropscience.com 

-, , C ,_ 

-,. , 

3 

,:' , 

'" ' 
20

( 

PREpTM brand Ethephon PLANT REGULATOR FOR COTTON 

FOR COMMERCIAL USE OR AGRICULTURAL USE ONLY. 

NOT FOR RESIDENTIAL USE. 

ACTIVE INGREDIENT: 

Ethephon (2-chloroethyJ) phosphonic acid" .......................................................................................................................................... 39.9% 

INERTINGREDIENTS: .................................................................................................................................................................................... 60.1% 

"This Product contains 4 pounds ethephon per gallon. 

EPA Reg. No. 264·380 EPA Est. No. 264·PA·01 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO NOTifiCATION 

1 9 20m Si usted no entiende la etiqueta, busque a alguien para que se la explique a usted en det~y'6 (If you do not understand the label, find someone to explain it to you in detaiL) 

For MEDICAL And TRANSPORTATION Emergencies ONLY Call 24 Hours A Day 1-800-334-7577 

For PRODUCT USE Information Call1-866·99BAVER (1-866-992-2937) 

FIRST AID 

IFIN EYES: • Hold eye open and rinse slowly and gently with water for 15-20 minutes. 

• Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. 

• Call a poison control center or doctor for treatment advice. 

IFON SKIN OR • Take off contaminated clothing. 

CLOTHING: 

• Rinse skin immediately with plenty of water for 15-20 minutes. 

• Call a poison control center or doctor for treatment advice. 

IF SWALLOWED: • Immediately call a p:lison control center or doctor for treatment advice. 

• Do not induce vomiting unless told to do so by a poison control center or doctor. 

• Have person sip a glass of water if able to swallow. 

• Do not give anythina by mouth to an unconscious person. 

For MEDICAL Emergencies Call 24 Hours A Day 1-800-334·7577. 

Have the Droduct container or label with you when ca/5na a DOison control center or doctor or aoina for treatment. 

NOTE TO PHYSICIAN: Treat symptomatically. Consideration should be given to the possibility that overexposure to materials other 

than this product may have occurred. No specific antidote is available. Probable mucosal damage may contraindicate the use of 

oastric lavaoe. ,. e 0 c 

PRECAUTIONARY STATEMENTS ," , 

DANGER 

HA2ARDS TO HUMANS AND DOMESTIC ANIMALS 

Corrosive. Causes irreversible eye damage and skin irritation. 

skin, or on clothing. 

Harmful or fatal jf swallowed. Avoid contamination of food. 

PERSONAL PROTECTIVE EQUIPMENT (PPE) 

., i 

Harmful If swallowed or absorbed through skin. Do not get in eyes, D .. '1< < 

Applicators and other handlers must YVear long-sleeved shirt and long pants, chemical resistant gloves made of any Waterproof material 

(such as Nitrile, Butyl, Neoprene and/or Barrier Laminate), shoes plus socks and protective eyewear. '.' , . 

When handlers use closed systems, enclosed cabs, or aircraft in a manner that meets the requirements listed in the W~rk~ Protection 

Standard (WPS) for agricultural pesticides [40 CFR 170.240 (d) (4-6)], the handler PPE requirements may be reduced or modified as 

specified in the WPS. 
21

( ( 

Discard clothing and other absorbent materials that have been drenched or heavily contaminated with this product's concentrate. Do 

not reuse them. Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables, use detergent 

and hot water. Keep and wash PPE separately from other laundry. 

User Safety Recommendations 

Users should wash hands before eating, drinking, chewing gum, using tobacco or using the toilet. 

Users should remove clothing immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing. 

Users should remove PPE immediately after handling this product. As soon as possible, wash thoroughly and change into clean 

clothimt Wash the outside of oloves before removino. 

ENVIRONMENTAL HAZARD 

Avoid spray drift to nearby crops as this product may cause temporary modifications in plant growth. Do not contaminate water used for 

irrigation or domestic purposes. 

00 not apply directly to water, or to areas where surface water is present or to intertidal areas below the mean high water mark. Do not 

contaminate water when disposing of equipment washwaters. 

00 not exceed the rate of PREpm brand Ethephon Plant Regulator for Cotton per acre per year recommended on this label. 

SPRAY DRIFT 

Avoid spray drift. 00 not apply when weather conditions may cause drift. 00 not allow this product to drift on to non-target areas. Drift 

may result in illegal residues or injury to adjacent crops and vegetation, in the form of leaf yellowing and defoliation. To avoid spray 

drift, DO NOT apply aerially when wind speed is greater than 10 mph or during periods of temperature inversions. Use of larger droplet 

size 'Mil also reduce spray drift. 

AVOIDING SPRAY DRIFT AT THE APPLICATION SITE IS THE RESPONSIBILITY OF THE APPLICATOR. 

The interaction of many equipment-and-weather-related factors determine the potential for spray drift The applicator is responsible for 

considering all these factors when making decisions. 

The following drift management reqUirements must be followed to avoid off-target movement from aerial applications to agricultural field 

crops. These requirements do not apply to forestry applications, public health uses or to app6cations using dry formulations. 

1. The distance of the outer most nozzles on the boom must not exceed 314 the length of the wingspan or rotor. 

2. Nozzles must always point backward parallel with the air stream and never be pOinted downwards more than 45 degrees. 

Where states have more stringent regulations, they should be observed. 

The applicator should be familiar with and take into accolB1t the information covered in the Aerial Drift Reduction Advisory below: 

AERIAL DRIFT REDUCTION ADVISORY 

[ThiS section is advisory in nature and does not supersede the mandatory label requirements'. 

INFORMA nON ON DROPLET SIZE 

The most effective way to reduce drift potential is to apply large dropiets. The best drift management strategy is to apply the largest 

droplets that provide sufficient coverage and control. Applying larger droplets reduces drift potential, but 'NIll not prevent drift if 

applications are made improperly, or under lB1favorable environmental conditions (See VVlnd, Temperature and Humidity, and 

Temperature Inversions). 

CONTROllING DROPLET SIZE 

Volume - Use high flow rate nozzles to apply the highest practical spray volume. Nozzles with higher rated flows produce larger 

droplets. 

Pressure - 00 not exceed the nozzle manufacturer's recommended pressures. For many nozzle types lower pressure produces larger 

droplets. When higher flow rates are needed, use higher flow rate nozzles instead of increasing pressure. 

Number of nozzles - Use the minimum number of nozzles that provide uniform coverage. 

Nozzle Orientation - Orienting nozzles so that the spray is released parallel to the airstream produces larger droplets than other 

orientations and is the recommended practice. Significant deflection from horizontal will reduce droplet size and increase drift potential. 

Nozzle Type - Use a nozzle type that is designed for the intended application. With most nOZZle types, narrower spray angles produce 

larger droplets. Consider using low-dr'ift nozzles. Solid stream nozzles oriented straight back produce the largest droplets and the 

lowest drift. 

BOOM LENGTH 

For some use pattems, reducing the effective boom length to less than 3f4 of the wingspan or rotor length may further reduce drift 

without reducing swath width. 

2 
22

( 

APPUCA TION HEIGHT 

Applications should not be made at a height greater than 10 feet above the top of the target plants unless a greater height is required 

for aircraft safety. Making applications at the lowest height that is safe reduces exposure of droplets to evaporation and wind. 

SWATH ADJUSTMENT 

When app~cations are made with a crosswind, the swath will be displaced downwind. Therefore, on the up and downwind edges of the 

field, the appficator should compensate for this displacement by adjusting the path of the aircraft upwind. Swath adjustment distance 

should increase, with increasing drift potential (higher wind, smaller drops, etc.). 

WIND 

Drift potential is lowest between wind speeds of 2 - 10 mph. However, many factors, including droplet size and equipment type 

determine drift p:Jtentia at any given speed. Appfication should be avoided below 2 mph due to variable wind direction and high 

inversion potential. NOTE: Local terrain can influence wind patterns. Every applicator should be familiar with local wind patterns and 

how they affect spray drift 

TEMPERATURE AND HUMIDITY 

When making applications in low relalive humidity, set up equipment to produce larger droplets to compensate for evap:Jration. Droplet 

evap:Jration is most severe when conditions are both hot and dry. 

TEMPERATURE INVERSIONS 

Applications should not occur during a temperature inversion because drift potential is high. Temperature inversions restrict vertical air 

mixing, which causes small suspended droplets to remain in a concentrated cloud. This cloud can move in unpredictable directions due 

to the light variable winds common during inversions. Temperature inversions are characterized by increasing temperatures with 

altitude and are common on nights with limited cloud cover and light to no wind. They begin to form as the sun sets and often continue 

into the morning. Their presence can be indicated by ground fog; however, if fog is not present, inversions can also be identified by the 

movement of smoke from a ground source or an aircraft smoke generator. Smoke that layers and moves laterally in a concentrated 

cloud (under low wind conditions) indicates an inversion, while smoke that moves upward and rapidly dissipates indicates good vertical 

air mixing. 

SENSmVE AREAS 

The pestic'lde should only be applled when the potential for drift to adjacent sensitive areas (e.g. residential areas, bodies of water, 

known habitat for threatened or endangered species, non-target crops) is minimal (e.g. when wind is blowing away from the sensitive 

areas). 

DIRECTIONS FOR USE 

It is a violation of Federal Jaw to use this product in a manner inconsistent with its labeling. 

Do not apply this product in a way that will contact workers or other persons, either directly or through drift. Only protected 

handlers may be in the area during application. For any requirements specific to your State or Tribe, consult the agency 

responsible for pesticide regulations. 

Read entire label before using this product 

AGRICULTURAL USE REQUIREMENTS 

Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR part 170. This standard contains 

requirements for the protection of agrirultural workers on farms, forests, nurseries, and greenhouses, and handlers of agricultural 

pesticides. It contains requirements for training, decontamination, notification, and emergency assistance. It also contains specific 

instructions and exceptiOns pertaining to the statements on this label about personal protective equipment (PPE). notification to workers 

and restricted-entry interval. The reqUirements in this box only apply to uses of this product that are covered by the Worker Protection 

Standard. 

Do not enter or allow worker entry into treated areas during the restrided-entry interval (REI) of 48 hours. The REI is 72 hours in areas 

where average rainfall is less than 25 inches per year. 

PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with 

anything that has been treated such as plants, soil or water is coveralls over long-sleeved shirt and long pants, chemical resistant 

gloves made of any waterproof material, such as nitrile. butyl, neoprene, or barrier laminate, chemical resistant footwear plus socks, and 

protective eyewear. For overhead exposure, chemical-resistant headgear is also required. 

Notify workers of the application by warning them orally and postin9.., warning signs at entrances to treated areas. 

3 
23

STORAGE AND DISPOSAL 

Do not contaminate water, food, or feed by storage or disposal. 

PESTICIDE STORAGE 

( 

Store in a cool, dry place and away from food, feed and other pesticides. IF SPILLED; If container is broken or contents have spilled, 

follow all precautions indicated above and clean up immediately. Before cleaning up, put on fun length trousers, long sleeved shirt, 

protective gloves, and goggles or face shield. Soak up spill with absorbent media such as sand, earth or other suitable material and 

dispose of waste at an approved waste disposal facility. 

PESTICIDE DISPOSAl 

Pesticide wastes are acutely hazardous. Improper disposal of excess pesticide, spray mixture, or rinsate is a violation of Federal law. If 

these wastes cannot be disposed of by use according to label instructions, contact your State Pesticide or Environmental Control 

Agency or the Hazardous Waste representative at the nearest EPA Regional Office for guidance. 

CONTAINER DfSPOSAL 

Rigid, Nonwrefilfable containers smalf enough to shake (i.e., with capaCities equal 10 or less1han 5 galfons) 

Non-refillable container. Do not reuse or refill this container. Triple rinse or pressure rinse container (or equivalent) promptly after 

emptying. Triple rinse as follows: Empty the remaining contents into appfication equipment or a mix tank and drain for 10 seconds after 

the flow begins to drip. Fill the container 1/4 fulf with water and recap. Shake for 10 seconds. Pour rinsate into application equipment or 

a mix tank or store rinsate for later use or disposal. Drain for 10 seconds after the flow begins to drip. Repeat this procedure two more 

times. Once container is rinsed, offer for recycling if available or puncture and dispose of in a sanitary landfill. 

RIgId Nonwreftllable containers tha1 are too large to shake (i.e., with capaCities greater than 5 gallons or 50 Ibs) 

Non-refillable ContaIners 

Non-refillable containers - Do not reuse or refill this container. Referto Bottom Discharge IBC or Top Discharge IBC, Drums, Kegs 

information as follows. 

Bottom Discharge IBC (e.g. - Schuetz caged lBe or Snyder SquareStackable) 

Pressure rinsing the container before final disposal is the responsibility of the person disposing of the container. To pressure rinse the 

container before final disposal, empty the remaining contents from the IBC into application equipment or mix tank. Raise the bottom of 

the IBC by 1.5 inches on the side which is opposite of the bottom discharge valve to promote more complete product removal. 

Completely remove the top lid of the IBC. Use water pressurized to at least 4D PSI to rinse all interior portions. Continuously pump or 

drain rinsate into application equipment or rinsate collection system whHe pressure rinsing. Continue pressure rinsing for 2 minutes or 

until rinsate becomes clear. Replace the lid and close bottom valve. 

Top Discharge IBC, Drums, Kegs (e.g.- Snyder 120 Next Gen, Bonar B120, Drums, Kegs). 

Triple rinsing the container before final disposal is the responsibmty of.the person disposing of the container. To triple rinse the 

container before final disposal, empty the remaining contents from this container into application equipment or mix tank. Fill the 

container at feast 10 percent fulf -....ith water. Agitate vigorously or recirculate water with the pump for 2 minutes. Rinse alf interior 

surfaces. Pour or pump rinsate into application equipment or rinsate COllection system. Repeat this procedure two more times. Once 

container is rinsed, offer for recycling if available or puncture and dispose of in a sanitary landfill. 

Refillable Containers 

Refillable container - Refer to Bottom Discharge IBC or Top Discharge .fBC, Drums, Kegs information as follows. Refill this container 

with pesticide only. Do not reuse this container for any other purpose. After emptying product from container, either retum container to 

Bayer CropScience per instructions from Bayer CropScience Customer Service Center (1-800-527-4781) or rinse and either recycle or 

disp::lse of the container as follows: 

Bottom Discharge IBC (e.g. - Schuetz Caged IBC or Snyder Square Stackable) 

Pressure rinsing the container before final disposal is the responsibility of the person disposing of the container. Cleaning before refilling 

is the responsibility of the refiller. To pressure rinse the container before final disposal, empty the remaining contents from the IBC into 

application equipment or mix tank. Raise the bottom of the IBC by 1.5 inches on the side which is opposite of the bottom discharge 

valve to promote more complete product removal. Completely remove the top lid of the IBC. Use water pressurized to at least 40 PSI to 

rinse all interior portiOns. Continuously pump or drain rinsate into application equipment or rinsate collection system while pressure 

rinsing. Continue pressure rinsing for 2 minutes or until rinsate becomes clear. Replace the lid and close bottom valve. 

Top DIscharge ISC, Drums, Kegs {e.g.- Snyder 120 Next Gen, Bonar B120, Drums, Kegs}. 

Triple rinsing the container before final disposal is the responsibifity of the person disposing of the container. Cleaning before refilling is 

the resp::lnsibility of the refiller. To triple rinse the containers before final disposal, empty the remaining contents from this container into 

application equipment or mix tank. Flff the container at least 10 percent full with water. Agitate vigoroUSly or recirculate water wilh the 

pump for 2 minutes. Rinse all interior surfaces. Pour or pump rinsate into application equipment or rinsate collection system. Repeat this 

procedure two more times. Once container is rinsed, offer for recycling if available or puncture and dispose of in a sanitary landfill. 

4 
24

( 

Refillable Containers 

End users are authorized to remove tamper evident cables as required to remove the product from the container unless the container is 

equipped with one way valves and refilling or returning is planned. If this is the case, end users are not authorized to remove tamper 

evident cables, one way valves or clean container. See Container Disposal instructions under Storage and Disposal. 

GENERAL INFORMATION 

A foliar spray of PREpTM brand Ethephon Plant Regulator for Cotton will accelerate opening of mature unopened cotton bolls and 

enhance defoliation which can result in earlier harvest with an increased recoverable yield. PREpTM brand Ethephon Plant Regulator 

for Cotton treatment allows increased efficiency from a once-over harvest. 

Some premature drop of small, immature bolls may be associated with treatment. Do not apply before sufficient, mature, unopened 

bolls have developed to produce the desired yield of cotton. 

A boll is mature when it is too hard to be dented when squeezed between thumb and fingers, too hard to be sliced with a sharp knife, 

and when the seed coat becomes light brown in color. 

For best results, thorough and uniform spray coverage is required. tt is essentia! that the bolls are contacted by the spray to obtain 

optimum boll opening. Observe treated fields closely. Harvest at optimum boll opening and defoliation, generally 14 to 21 days after 

treatment. Sustained cold weather with average day and night temperatures ci 65°F or lower after treatment with PREpTM brand 

Ethephon Plant RegUlator for Cotton will de!ay the boll opening response. 

DO NOT APPLY PREpTM BRAND ETHEPHON PLANT REGULATOR FOR COTTON !F RAIN IS EXPECTED W!THIN 6 HOURS. 

Rainfall within 6 hours of application may reduce product performance. 

Certified cotton seed growers shou!d observe boll and seed maturity before treatment VYith PREPTM brand Ethephon Plant Regulator for 

Cotton. Bolls not completely mature might open with treatment of PREpTM brand Ethephon Plant Regulator for Cotton giving 10\oVer 

quality seed. 

IMPORTANT: Do not apply PREPTM brand Ethephon Plant Regulator for Cotton through any type of irrigation system. 

SPRAY PREPARATION 

Add 1/2 to 3/4 of the required amount of water to the spray tank. Start agitation. Add the required amount of PREpTM brand Ethephon 

Plant Regulator for Cotton, and the remaining amount of water. Prepare only as much spay solution as can be used on the day of 

mixing. Do not allow spray solution to stand overnight. 

Do not spill the concentrated product on spray equipment, or any airplane parts. ANY SPILLS SHOULD BE RINSED IMMEDIATELY 

WITH PLENTY OF WATER. 

Use of a nurse tank is highly recommended for avoiding possible spills of concentrated formulation on spray equipment or any airplane 

parts. 

EQUIPMENT ClEANING 

Spray depOSits of PREpTM brand Ethephon Plant Regulator for Cotton, when left on aircraft acrylic plastic type windshields for longer 

than 1 hour, may react with this material, forming an opaque film or spots on the surface which cannot be removed by washing with 

water or any other cleaner. Rinse windshields with water immediately· after each tankload of PREpTM brand Ethephon Plant Regulator 

for Cotton has been applied. Thoroughly rinse the aircraft with clean water after each day PREpTM brand Ethephon Plant Regulator for 

Cotton is appfled. 

PREpTM brand Ethephon Plant Regulator for Cotton may also affect certaIn paints, and if accidental depoSits on painted objects such 

as cars, trucks, agriCUltural equipment, etc. occurs, these objects should be rinsed with water as soon as possible (within 1 hcur) to 

prevent permanent staining of the painted surface. 

Because of the acidic nature of this product, prolonged exposure to spray deposit wi!! damage acrylic plastiCS, certain paints, and 

metals. 

Rinse thoroughly with a detergent and water all exposed acrylic plastic-type materials (e.g., aircraft windshields), and painted surfaces 

within an hour after exposure to spray deposits. At the end of each day, rinse thoroughly with a detergent and water all the metal parts 

of the aircraft and the associated spray equipment exposed to the spray depOSits. 

5 
25

BOll OPENING 

CONDITIONS EXPECTED 

5-7 DAYS AFTER 

TREATMENT 

Hot and dry 80"F or higher 

Dry with temperature 

75"Fto 80"F 

Cool but higher than 65"F 

Rank cotton 

Rates FOf Boll Opening 

PREpTh! brand Ethephon ONE GALLON OF 

Plant Regulator for Cotton PREpTh! brand Ethephon 

Plant Regulator for Cotton 

QUARTS/ACRE TREATS 

1.0 (1.0 Ib aJ.) 4 Acres 

1.5(1.5IbaJ.) 2.5 Acres 

2.0 (2.0 Ib aJ.) 2 Acres 

2.0 (2.0 Ib aJ.) 2 Acres 

SPRAY VOLUME 

GAl.IACRE 

GROUND AIR 

15 to 50 2 to 5* 

15 to 50 2 to 5* 

15 to 50 2 to 5* 

25 to 50 5 

*NOTE: For California and Arizona use a volume of no less than 5 gallons per acre for aerial applications 

TIme of Application (8011 Opening) 

Apply when there are sufficient mature unopened bolls to produce the desired yield, but no later than when 60% of the bolls are opened 

(see General Information section on how to test for boll maturity). Do not tank mix PREpTM brand Ethephon Plant Regulator for Cotton 

with a desiccant if the cotton is to be spindle harvested. 

PRECONDITIONING FOR DEFOLIATION 

Rates For Preconditioning For Defoliation 

CONDITIONS EXPECTED 

5-7 DAYS AFTER 

TREATMENT 

Hot and dry BO"F or higher 

Cool but higher than 65"and 

also for rank cotton 

PREpTM brand Ethephon 

Plant Regulator for Cotton 

QUARTS/ACRE 

0.5 (0.5 Ib aJ.) 

1.0 (1.0 Ib a.i.) 

ONE GALLON OF 

PREpTM brand Ethephon 

Plant Regulator for Cotton 

TREATS 

8 Acres 

4 Acres 

SPRAY VOLUME 

GAL.1ACRE 

GROUND AIR 

15 to 50 

15to50 

2t05* 

2 to 5* 

*NOTE: For California and Arizona use a volume of no less than 5 gallons per acre for aerial applications. 

Time of Application (Preconditioning) 

Apply PREpTh! brand Ethephon Plant Regulator for Cotton 4 to 7 days prior to application of defoliant or tank mixed with the defoliant 

(see section on Compatibility). Do not tank mix PREpTM brand Ethephon Plant Regulator for Cotton with desiccants unless plant 

desiccation is required. 

Pre-treatment With Defoliants Prior to PREpTM brand Ethephon Plant Regulator for Cotton Treatment 

If the cotton is overly rank or laying down in the middles and good spray coverage of the bolls with PREpTM brand Ethephon Plant 

Regulator for Cotton is difficult, a pretreatment with defoliants will be useful to improve boll coverage with PREpTM brand Ethephon 

Plant Regulator for Cotton. Use dosage rates of PREpTM brand Ethephon Plant Regulator for Cotton recommended for boll opening. 

Read and observe all appropriate label use directions and precautions for the defoliant used. 

Do not use a defoliant before there are sufficient mature unopened bolls to produce the desired yield (see General Information section 

on how to test for Boll Maturity). 

COMPATIBIUTY 

PREpTM brand Ethephon Plant Regulator for Cotton is compatible with DEF, FOLEX, DROPP, HARVADE, METHYL PARATHION, 

GUTHION AND MALATHION, and may be applied in sequence or as a tank mixture (DO NOT TANK MIX WITH DEFOLIANTS OR 

DESICCANTS IN CALIFORNIA AND ARIZONA). In some cases slight reduction in boll opening response has been observed when 

tank mixes with defoliants were used. 

Good agitation in the spray tank is essential and a tank mixture should not be allowed to stand without agitation for more than 5 to 10 

minutes. Read and observe all appropriate label use directions and precautions for the defoliants and insecticides used. 

6 
26

( 

PRECAUTION: 

NOTE: UNDER CERTAIN CONDITIONS, TANK MIXTURES OF PREpThl BRAND ETHEPHON PLANT REGULATOR FOR COTTON 

WITH DESICCANTS CONTAINING SODIUM CHLORATE COULD RESULT IN THE FORMATION OF HYPOCHLOROUS ACIDS 

WHICH ON HEATING WILL EMIT TOXIC CHLORIDE FUMES. 

DO NOT MIX PREpTM BRAND ETHEPHON PLANT REGULATOR FOR conON WITH AMMONIUM THIOSULFATE SUCH TANK 

MIXTURES MAY RESULT IN FORMATION OF TOXIC FUMES. 

WHEN TO HARVEST: 

Do not harvest cotton sooner than 7 days after a treatment with PREPTM brand Ethephon Plant Regulator for Cotton. Observe the 

treated crop and harvest when optimum boll opening has been reached. Too early harvest might reduce the full advantage of the 

treatment and too late a harvest may result in reduced quality and foss of lint which will drop from the plant. 

USE UMITATIONS 

Do not exceed a maximum of 2.0 lb. ethephon active ingredient per acre per year through combined or repeated uses of any 

ethephon products. 

Boll Opening: Do not tank mix PREpTM brand Ethephon Plant Regulator for Cotton with a desiccant if the cotton is to be spindle 

harvested. 

Pre-Condition for Defoliation: Do not tank mix PREpTM brand Ethephon Plant Regulator for Cotton with desiccants unless plant 

desiccation is required. Do not use a defoliant before there is sufficient mature unopened bolls to produce the desired yield (see 

General Information section on how to test for boll maturity. 

Do not plant another crop within 30 days after treatment. 

USE PRECAUTIONS 

Avoid spray drift to nearby crops as this product will cause modifications in plant growth. Plant injury or reduced yields will result. 

Mix only the amount of spray you expect to use each day. Do not allow mixed solution to stand overnight. 

7 
27

{ ! 

IMPORTANT: READ BEFORE USE 

Read the entire Directions for Use, Conditions, Disclaimer of Warranties and Limitations of liability before using this product. If terms 

are not acceptable, retum the unopened product container at once. 

By using this product. user or buyer accepts the following Conditions, Disclaimer of warranties and Limitations of liability. 

CONDITIONS: The directions for use of this product are believed to be adequate and must be followed carefully. However, it is 

impossible to eliminate all risks associated with the use of this product Crop injury, ineffectiveness or other unintended consequences 

may result because of such factors as weather conditions, presence of other materials, or the manner of use or application, all of which 

are beyond the control of Bayer CropScience. All such risks shall be assumed by the user or buyer. 

DISCLAIMER OF WARRANTIES: TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, BAYER CROPSCIENCE MAKES NO 

OTHER WARRANTIES, EXPRESS OR IMPLIED, OF MERCHANTABILITY OR OF FITNESS FOR A PARTICULAR PURPOSE OR 

OTHERWISE, THAT EXTEND BEYOND THE STATEMENTS MADE ON THIS LABEl. No agent of Bayer CropScience is authorized to 

make any warranties beyond those contained herein or to modify the warranties contained herein. TO THE EXTENT CONSISTENT 

WITH APPLICABLE LAW, BAYER CROPSCIENCE DISCLAIMS ANY LIABILITY WHATSOEVER FOR SPECIAl, INCIDENTAl OR 

CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT. 

LIMITATIONS OF LIABILITY; TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, THE EXCLUSIVE REMEDY OF THE 

USER OR BUYER FOR ANY AND AlL LOSSES, INJURIES OR DAMAGES RESUL TlNG FROM THE USE OR HANDLING OF THIS 

PRODUCT, WHETHER IN CONlR.OCT, ~, TORT, NEGUGEJ-.K;E, STRICT lJOBIUTY OR OTI-ER'MSE, SI-W.L l'K)T EXCEED THE 

Pl..JROV\SE PRICE PAID, ORAT BAYER CROPSClENCE'S El...ECTlCN THE REPlACEMENT OF PRODUCT. 

Bayer CropScience lP 

P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, North Carolina 27709 

1-866-99BAVER (1-866-992-2937) 

PREpm brand Ethephon Plant Regulator for Cotton (PENDING) 08/05/10 

8 
28

( 

STORAGE AND DISPOSAL 

Do not contaminate water, food, or feed by storage or disposal. 

PESTlC[DE STORAGE 

I 

Store in a cool, dry place and away from food, feed and other pesticides. [F SP[LLED: [f container is broken or contents have spilled, 

follow all precautions indicated above and clean up immediately. Before cleaning up, put on full length trousers, long sleeved shirt, 

protective gloves, and goggles or face shield. Soak up spill with absorbent media such as sand, earth or other suitable material and 

dispose of waste at an approved waste disposal facility. 

PEST[CIDE D[SPOSAL 

Pesticide wastes are acu[ely hazardous. Improper disposal of excess pesticide, spray mixture, or rinsate is a violation of Federal law. [f 

these wastes cannot be disposed of by use according to label instructions, contact your State Pestic'lde or Environmenta[ Control 

Agency or the Hazardous Waste representative at the nearest EPA Regional Office for guidance. 

CONTAINER DISPOSAL 

Rigid, Non-refillab[e containers small enough to shake (I.e., with capacities equal to or less than 5 gallons) 

Non-refillab[e container. Do not reuse or refill this container. Trip[e rinse or pressure rinse container (or equivalent) promptly after 

emptying. Triple rinse as follows: Empty the remainlng contents into app~cation equipment or a m'lx tank and drain for to seconds after 

the flow begins to drip. Fill the container t/4 full with water and recap. Shake for to seconds. Pour rinsate into application equipment or 

a mix tank or store rinsate for later use or disposal. Drain for 10 seconds after the flow begins to drip. Repeat this procedure two more 

times. Once container is rinsed, offerfor recycling if availab[e or puncture and dispose of in a sanitary landfill. 

Rigid Non-refillable contaIners that are too large to shake {I.e., with capacities greater than 5 gallons or 50 [bs} 

Non-refillable Containers 

Non-refillab[e containers - Do not reuse or refill this container. Refer to Bottom Discharge IBC or Top Discharge [BC, Drums, Kegs 

information as fol[ows. 

Bottom Discharge IBC (e.g. - Schuetz Caged IBC or Snyder Square Stackab[e) 

Pressure rinsing the container before final disposal is the responsibility of the person disposing of the container. To pressure rinse the 

container before final disposal, empty the remaining contents from the [BC into application equ'rpmert or mix tank. Raise the bottom of 

the [BC by 1.5 inches on the side v.ttich is opposite of the bottom discharge valve to promote more complete product removal. 

Comp[etely remove the top lid of the [BC. Use water pressurized to at [east 40 PS[ to rinse aU interior portions. Continuously pump or 

drain rinsate into application equipment or rinsate collection system 'Nhile pressure rinSing. Continue pressure rinsing for 2 minutes or 

until rinsate becomes clear. Replace the lid and close bottom valve. 

Top Discharge IBC, Drums, Kegs {e.g.- Snyder 120 Next Gen, Bonar B120, Drums, Kegs}. 

Trip[e rinsing the container before fina[ disposal is the responsibility of the person disposing of the container. To triple rinse the 

container before final disposal, empty the remainillJ contents from this container into application eqUipment or mix tank. Fill the 

container at [east to percent full with water. Agitate vigorously or recirculate water with the pump for 2 minutes. Rinse all interior 

surfaces. Pour or pump ri~te into application equipment or rin~e C9!tection system. Repeat this procedure two more times. Once 

container is rinsed, offer for· recycling if availab[e or puncture and dispOse of In a sanitary landfill. 

Refillable Containers 

Refillable container- Refer to BottQm Discharge IBC or Top DischargeJaC, Drums, Kegs infonnation as follows. Refill this container 

with pesticide only. Do not reuse this container for any other purpose. After emptying product from container, either return container to 

Bayer CropScience perinstructions from Bayer CropScience Customer Service Center (1-800-527-4781) or rinse and either recycle or 

dispose of the container as follows: 

Bottom Discharge IBC (e.g. - Schuetz Caged IBC or Snyder Square Stackable) 

Pressure rinsing the container before fina[ disposal Is the responsibility of the person disposing of the container. Cleaning before refilling 

is the responsibility of the refiller. To pressure rinse the container before final dlsposa[, empty the remaining contents from the [BC into 

application equipment or mix tank. Raise the bottom of the [BC by 1.5 inches on the side 'Nhich is opposite of the bottom discharge 

valve to promote more complete product removal. Comp[etely remove the top lid of the [BC. Use water pressurized to at least 40 PSI to 

rinse all interior portions. ContinuousfY pump or drain rinsate into application equipment or rinsate collection system 'Nhile pressure 

rinsing. Continue pressure rinsing for 2 minutes or until rinsate becomes dear. Reptace the [jcf and close bottom valve. 

Top Discharge IBC, Drums, Kegs (e.g._ Snyder 120 Next Gen, Bonar B120, Drums, Kegs). 

Triple rinsing the container before final disposal is the responsibility of the person disposing of the container. Oeaning before refiDing is 

the responsibility of the refiller. To triple rinse the containers before final disposal, empty the remaining contents from this container into 

application equipment or mix tank. An the container at [east 10 percent full with water. Agitate vigorousfy or recirculate water viilh the 

pump for 2 minutes. Rinse all interior surfaces. pour or pump rinsate into application equipment or rinsate coUection system. Repeat this 

procedure two more times. Once container is rinsed, offer for recycling if availab[e or puncture and dispose of in a sanitary landfill. 

4 
29

Refillable Containers 

End users are authorized to remove tamper evident cables as required to remove the product from the container unless the container is 

equipped with one way valves and refilling or returning is planned. If this is the case, end users are not authorized to remove tamper 

evident cables, one way valves or clean container. See Container Disposal instructions under Storage and Disposal. 

GENERAL INFORMATION 

A foliar spray of PREpTM brand Ethephon Plant Regulator for Cotton will accelerate opening of mature unopened cotton bolls and 

enhance defoliation which can result in earlier harvest with an increased recoverable yield. PREPThl brand Ethephon Plant Regulator 

for Cotton treatment allows increased efficiency from a once-over harvest. 

Some premature drop of small, immature bolls may be associated with treatment. Do not apply before sufficient, mature, unopened 

bolls have developed to produce the desired yield of cotton. 

A boll is mature when it is too hard to be dented when squeezed between thumb and fingers, too hard to be sliced with a sharp knife, 

and when the seed coat becomes light brown in color. 

For best results, thorough and uniform spray coverage is required. It is essential that the bolls are contacted by the spray to obtain 

optimum boll opening. Observe treated fields closely. Harvest at optimum boll opening and defoliation, generally 14 to 21 days after 

treatment. Sustained cold weather with average day and night temperatures of 65°F or lower after treatment with PREpTM brand 

Ethephon Plant Regulator for Cotton will delay the boll opening response. 

DO NOT APPLY PREpTM BRAND ETHEPHON PLANT REGULATOR FOR COTTON IF RAIN IS EXPECTED WITHIN 6 HOURS. 

Rainfall within 6 hours of application may reduce product performance. 

Certified cotton seed growers should observe boll and seed maturity before treatment with PREpTM brand Ethephon Plant Regulator for 

Cotton. Bolls not completely mature might open with treatment of PREpTM brand Ethephon Plant Regulator for Cotton giving lower 

quality seed. 

IMPORTANT: Do not apply PREpTM brand Ethephon Plant Regulator for Cotton through any type of irrigation system. 

SPRAY PREPARATION 

Add 112 to 314 of the required amount of water to the spray tank. Start agitation. Add the required amount of PREpm brand Ethephon 

Plant Regulator for Cotton, and the remaining amount of water. Prepare only as much s]:X"8y solution as can be used on the day of 

mixing. Do not allow spray solution to stand overnight. 

Do not spill the concentrated product on spray equipment, or any airplane parts. ANY SPILLS SHOULD BE RINSED IMMEDIATELY 

WITH PLENTY OFWATER. 

Use of a nurse tank is highly recommended for avoiding possible spills of concentrated formulation on spray equipment or any airplane 

parts. 

EQUIPMENT CLEANING 

Spray deposits of PREpTM brand Ethephon Plant Regulator for Cotton, when left on aircraft acrylic plastiC type windshields for longer 

than 1 hour, may react with this material, forming an opaque film or spots on the surface which cannot be removed by washing with 

water or any other cleaner. Rinse windshields with water immediately after each tankload of PREpTM brand Ethephon Plant Regulator 

for Cotton has been applied. Thoroughly rinse the aircraft with clean ~~er after eadl day PREp1"M brand Ethephon Plant Regulator for 

Cotton is applied. 

PREpTM brand Ethephon Plant Regulator for Cotton may also affect certain paints, and if accidental deposits on painted objects such 

as cars, trucks, agricultural eqUipment, etc. occurs, these objects should be rinsed with water as soon as possible (within 1 hour) to 

prevent permanent staining of the painted surface. 

Because of the acidic nature of this product, prolonged exposure to spray deposit will damage acrylic plastics, certain paints, and 

metals. 

Rinse thoroughly with a detergent and water all exposed acrylic plastic-type materials (e.g., aircraft windshields), and painted surfaces 

within an hour after exposure to spray deposits. At the end of each day, rinse thoroughly with a detergent and water all the metal parts 

of the aircraft and the associated spray equipment exposed to the spray deposits. 

5