FIRST
AMENDMENT TO SECOND AMENDED AND RESTATED LICENSE


AGREEMENT


This
First Amendment (this “Amendment”) is made on November __, 2017 as an amendment to the Second Amended and Restated
License Agreement of June 15, 2017 (the "Agreement"), by and between HADASIT MEDICAL RESEARCH SERVICES AND
DEVELOPMENT LTD. (“Hadasit”) and CELL CURE NEUROSCIENCES LTD. (the “Company”)
(each a “Party” and jointly the “Parties”), effective as of the same date as the Agreement.


 


	WHEREAS:	The
                                         Parties have discussed the terms of the Agreement and have mutually agreed to further
                                         amend the Agreement terms as set out herein.



 


NOW
THEREFORE THE PARTIES DO HEREBY AGREE AS FOLLOWS:


 


	1.	Capitalized
                                         terms used but not defined herein shall, unless otherwise indicated, have the meaning
                                         ascribed to such terms in the Agreement.



 


	2.	Annex
                                         A which lists the Licensed Patents is hereby replaced, in its entirety, with the updated
                                         listing dated October 24, 2017 attached hereto and marked “Annex A – Patents”.



 


	3.	The
                                         Parties hereby acknowledge and confirm that while Cell Cure has borne the costs of US
                                         patent 8597947 directed at undifferentiated stem cell culture systems, such patent is
                                         not included in the Licensed Patents. Therefore, Hadasit shall reimburse Cell Cure for
                                         such costs in a total of NIS 146,656.08 by no later than November 15, 2017. Cell Cure
                                         shall be entitled to set any unpaid portion of this debt off against any amounts that
                                         become due to be paid by Cell Cure to Hadasit under the Agreement from time to time,
                                         by written notice to Hadasit. 



 


	4.	Except
                                         as specifically provided in and required by this Amendment, the terms and conditions
                                         of the Agreement shall remain in full force and effect. In the event of a contradiction
                                         between the provisions of this Amendment and the provisions of the Agreement, the provisions
                                         of this Amendment shall prevail.



 




    	1 



    	 



    


 


IN
WITNESS WHEREOF, the Parties have duly executed this Amendment:


 





	HADASIT
    	 	 	CELL
    CURE NEUROSCIENCES Ltd.
	 	 	 	 	 	 
	By:	/s/
    Dr. Tamar Raz	 	 	By:	/s/
    Rami Skaliter
	 	 	 	 	 	 
	Name:	Dr,
    Tamar Raz	 	 	Name:	Rami
    Skaliter
	 	 	 	 	 	 
	Title:	Chief
    Executive Officer	 	 	Title:	Chief
    Executive Officer
	 	 	 	 	 	 
	Date:	December
    18, 2017	 	 	Date:	January
    8, 2018









 


Attached:
Annex A - Patents


 




    	2 



    	 



    


 


Appendix
A – Patent Listing


 





	Family:	3440	Title:	Reverse
    hexagonal mesophases (hii) and uses thereof







 


	Inventor	 	 	University	 	 	 	Faculty	 	 	Department
	 	 	 	 	 	 	 	 	 	 	 
	Amar-Yuli
    Idit	 	 	HUJI	 	 	 	Faculty
                                         of Science	 	 	The
    Institute of Chemistry
	Aserin
    Abraham	 	 	HUJI	 	 	 	Faculty
                                         of Science	 	 	The
    Institute of Chemistry
	Bitan-Cherbachovsky
    Liron	 	 	HUJI	 	 	 	Faculty
                                         of Science	 	 	The
    Casali Center for Applied Chemistry
	Libster
    Dima	 	 	HUJI	 	 	 	Faculty
                                         of Science	 	 	The
    Casali Center for Applied Chemistry
	Mishraki
    Tehila	 	 	HUJI	 	 	 	Faculty
                                         of Science	 	 	The
    Casali Center for Applied Chemistry
	Garti
    Nissim	 	 	HUJI	 	 	 	Faculty
                                         of Science	 	 	The
    Institute of Chemistry





 








	Patent
    ID	 	Application
    Status	 	Country	 	Date	 	Publication
    Number	 	Date	 	Patent
    Number
	3440-00	 	Expired	 	US	 	25/06/2009	 	61/220,398	 	 	 	 
	3440-01	 	Expired	 	US	 	09/02/2010	 	61/302,649	 	 	 	 
	3440-02	 	Exhausted	 	PCT	 	24/06/2010	 	PCT/IL2010/000507	 	29/12/2010	 	WO
    2010/150262
	3440-03	 	Examination	 	Europe	 	24/06/2010	 	10738041.2	 	19/09/2012	 	2498754
	3440-04	 	Allowed	 	Israel	 	24/06/2010	 	217115	 	 	 	 
	3440-05	 	Examination	 	US	 	24/06/2010	 	13/379,769	 	07/02/2013	 	US-2013/0034538




 





	Family:	6150	Title:	A
    novel method for the solubilization of cannabis based on improved modified NSSL







 


	Inventor	 	 	University	 	 	 	Faculty	 	 	Department
	Aserin
    Abraham	 	 	HUJI	 	 	 	Faculty
    of Science	 	 	The
    Institute of Chemistry
	GARTI
    LEVI Sharon	 	 	 	 	 	 	 	 	 	 
	Garti
    Nissim	 	 	HUJI	 	 	 	Faculty
    of Science	 	 	The
    Institute of Chemistry




 






	Patent
    ID	 	Application
    Status	 	Country	 	Date	 	Publication
    Number	 	Date	 	Patent
    Number
	6150-00	 	Filed	 	NA	 	29/09/2016	 	248149	 	 	 	 




 





	Family:	6151
    	Title:	A
    novel process for the extraction of CBD/THC using NSSL







 


	Inventor	 	 	University	 	 	 	Faculty	 	 	Department
	Aserin
    Abraham	 	 	HUJI	 	 	 	Faculty
    of Science	 	 	The
    Institute of Chemistry
	Edri
    Rotem	 	 	 	 	 	 	 	 	 	 
	GARTI
    LEVI Sharon	 	 	 	 	 	 	 	 	 	 
	Garti
    Nissim	 	 	HUJI	 	 	 	Faculty
    of Science	 	 	The
    Institute of Chemistry




 





	Patent
    ID	 	Application
    Status	 	Country	 	Date	 	Publication
    Number	 	Date	 	Patent
    Number
	6151-00	 	Filed	 	Israel	 	29/09/2016	 	248150	 	 	 	 




 



    	3 



    	 



    

 


APPENDIX
C – DEVELOPMENT PLAN


 


	Stage	 	Description
    (Activities to be done either by the Company, a Company Affiliate or a Sublicensee)	 	Timeline
    Milestones – each an Essential  Milestone
	 	 	 	 	 
	Toxicology	 	Completion
    of formal pre-clinical toxicology studies	 	50
    months from the Effective Date
	 	 	 	 	 
	Phase
    I	 	Initiation
    of a Phase I clinical trial with the selected formulated drug	 	72
    months from the Effective Date
	 	 	 	 	 
	Phase
    III	 	Initiation
    of a Phase III clinical trial with the selected formulated drug 	 	90
    months from the Effective Date
	 	 	 	 	 
	First
    Commercial Sale	 	First
    Commercial Sale of the  selected formulated drug	 	108
    months from the Effective Date




 


For
purposes of this Appendix C, Effective Date shall mean the date of the Third Amendment (i.e. February 9, 2017).


 




    	4 



    	 



    


 


October
24, 2017


 


Annex
A 


Patents


 


Part
I – Licensed Patents on the Effective Date (status as of the Date of the Second Amendment) 


 


	STEM
                                         CELLS CULTURE SYSTEMS – Only claims 20-39 of PCT application IL2005/001397 (249-01)
                                         and the parts of the correponding National Phase applications that include the mentioned
                                         claims are included in the exclusive license granted to the Company. In addition CellCure
                                         will have a limited non-exclusive right under claims 1-3 of PCT application IL2005/001397
                                         (249-01) and the parts of the correponding National Phase applications that include the
                                         mentioned claims, solely to the extent necessary to use the Licensed Feeder Cell Line
                                         (as such term is defined in the Agreement) in accordance with the terms of the Agreement.
                                         CellCure will not have any other rights under claims 1-3. Without limiting the generality
                                         of the foregoing, no rights are granted under claims 1-3 of the abovementioned patent
                                         applications with respect to any feeder cell lines other than the Licensed Feeder Cell
                                         Lines.

                                                                                                                                                                                                    

	Our
                                         Ref

        Client
        Ref
	Country	Earliest
    Priority 	Entry
    Date 	Filing
                                         Date

        Application
        No.
	Publication
                                         Date + No.

        Issue
        Date + Patent No.
	Status	Assignee

        Inventor

	47631

        249-00
	USA

        PRO
	 	 	29-Dec-2004

        60/639,809
	 	Expired	Hadasit
                                         Medical Research Services and Development Ltd.

        BEN-SHUSHAN
        Etti ; TANNENBAUM Shelly ; ITSYKSON Pavel ; BANIN Eyal ; REUBINOFF Benjamin Eithan

	47632

        249-01
	PCT 
	29-Dec-2004

        60/639,809
	 	29-Dec-2005

        IL2005/001397
	Publ.
                                         Date: 06-Jul-2006

        Publ.
        #: WO2006/070370
	Expired	Hadasit
                                         Medical Research Services and Development Ltd.

        BEN-SHUSHAN
        Etti ; TANNENBAUM Shelly ; ITSYKSON Pavel ; BANIN Eyal ; REUBINOFF Benjamin Eithan

	66284

        249-10
	Europe

        DIV
	29-Dec-2004

        60/639,809
	15-Jul-2011	29-Dec-2005

        11174158.3
	Publ.
                                         Date: 25-Jan-2012

        Publ.
        #: 2410044
	Pending	Hadasit
                                         Medical Research Services and Development Ltd.

        BEN-SHUSHAN
        Etti ; TANNENBAUM Shelly ; ITSYKSON Pavel ; BANIN Eyal ; REUBINOFF Benjamin Eithan

	249-03	05821535.1

        Europe

        Validated
        in 7 European countries
	29-Dec-2004

        60/639,809
	 	29-Dec-2005

         
	 EP1844136
    B1	 

        Granted

         

        27.8.14
	Hadasit
                                         Medical Research Services and Development Ltd.

        BEN-SHUSHAN
        Etti ; TANNENBAUM Shelly ; ITSYKSON Pavel ; BANIN Eyal ; REUBINOFF Benjamin

	249-09	 

        US

        13/005,978
	29-Dec-2004

        60/639,809
	January
    13, 2011	29-Dec-2005
	US20110177594

        US9005965
        BB
	Issued

        April
        14, 2015
	Hadasit
                                         Medical Research Services and Development Ltd.

        BEN-SHUSHAN
        Etti ; TANNENBAUM Shelly ; ITSYKSON Pavel ; BANIN Eyal ; REUBINOFF Benjamin



 


	STEM
    CELL-DERIVED RETINAL PIGMENT EPITHELIAL CELLS 
	Our
                                         Ref

        Client
        Ref
	Country	Earliest
    Priority 	Entry
    Date 	Filing
                                         Date

        Application
        No.
	Publication
                                         Date + No.

        Issue
        Date + Patent No.
	Status	Assignee

        Inventor

	47433

        315-01
	PCT

         
	18-Apr-2007

        60/907,818
	 	27-Apr-2008

        IL2008/000556
	Publ.
                                         Date: 30-Oct-2008

        Publ.
        #: WO2008/129554
	Expired	Hadasit
                                         Medical Research Services and Development Ltd.

        IDELSON
        Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan

	47434

        315-04
	USA

        NP
	18-Apr-2007

        60/907,818
	19-Oct-2009	27-Apr-2008

        12/450,943
	Publ.
                                         Date: 03-Feb-2011

        Publ.
        #: 2011-0027333-A1

        17-Feb-2015

        8,956,866
	Granted	Hadasit
                                         Medical Research Services and Development Ltd.

        IDELSON
        Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak

	RETINAL
    PIGMENT EPITHELIAL CELLS DIFFERENTIATED FROM EMBRYONIC STEM CELLS WITH NICOTINAMIDE AND ACTIVIN 
	Our
                                         Ref

        Client
        Ref
	Country	Earliest
    Priority 	Entry
    Date 	Filing
                                         Date

        Application
        No.
	Publication
                                         Date + No.

        Issue
        Date + Patent No.
	Status	Assignee
                                         Inventor

	61423

        315-14
	USA

        DIV
	18-Apr-2007

        60/907,818
	29-Dec-2014	27-Apr-2008

        14/583,838
	Publ.
                                         Date: 07-May-2015

        Publ.
        #: 2015-0125506-A1
	Pending	Hadasit
                                         Medical Research Services and Development Ltd.

        IDELSON
        Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak

	61424

        315-15
	USA

        DIV
	18-Apr-2007

        60/907,818
	29-Dec-2014	27-Apr-2008

        14/583,848
	Publ.
                                         Date: 30-Apr-2015

        Publ.
        #: 2015-0118749-A1
	Pending	Hadasit
                                         Medical Research Services and Development Ltd.

        IDELSON
        Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak




 



    	Page 1 of 6



    	 



    

 


	STEM
    CELL-DERIVED RETINAL PIGMENT EPITHELIAL CELLS 
	Our
                                         Ref

        Client
        Ref
	Country	Earliest
    Priority 	Entry
    Date 	Filing
                                         Date

        Application
        No.
	Publication
                                         Date + No.

        Issue
        Date + Patent No.
	Status	Assignee
                                         Inventor

	47435

        315-03
	Europe

        NP
	18-Apr-2007

        60/907,818
	18-Nov-2009	27-Apr-2008

        08738258.6
	Publ.
                                         Date: 27-Jan-2010

        Publ.
        #: 2147094

        08-Oct-2014

        2147094
	Granted	Hadasit
                                         Medical Research Services and Development Ltd.

        IDELSON
        Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak

	49360

        315-10
	Hong
                                         Kong

        NP
	18-Apr-2007

        60/907,818
	20-Jul-2010	27-Apr-2008

        10107017.2
	Publ.
                                         Date: 22-Oct-2010

        Publ.
        #: 1140791A

        27-Mar-2015

        HK1140791
	Granted	Hadasit
                                         Medical Research Services and Development Ltd.

        IDELSON
        Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak

	54561

        315-11
	Europe

        DIV
	18-Apr-2007

        60/907,818
	21-Aug-2012	27-Apr-2008

        12181140.0
	Publ.
                                         Date: 06-Feb-2013

        Publ.
        #: 2554661

        19-Nov-2014

        2554661
	Granted	Hadasit
                                         Medical Research Services and Development Ltd.

        IDELSON
        Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak

	61018

        315-12
	Europe

        DIV
	18-Apr-2007

        60/907,818
	18-Nov-2014	27-Apr-2008

        14193621.1
	Publ.
                                         Date: 24-Jun-2015

        Publ.
        #: 2886646
	Pending	Hadasit
                                         Medical Research Services and Development Ltd.

        IDELSON
        Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak

	56710

        315-16

         
	Hong
                                         Kong

        DIV
	18-Apr-2007

        60/907,818
	04-Jun-2013	27-Apr-2008

        13106571.9
	24-Jul-2015

        HK1179647
	Granted	Hadasit
                                         Medical Research Services and Development Ltd.

        IDELSON
        Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak

	64780

        315-17
	Hong
                                         Kong

        DIV
	18-Apr-2007

        60/907,818
	16-Dec-2015	27-Apr-2008

        15112372.6
	Publ.
                                         Date: 27-May-2016

        Publ.
        #: 1211619A
	Pending	Hadasit
                                         Medical Research Services and Development Ltd.

        IDELSON
        Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak

	47436

        315-08
	Australia

        NP
	18-Apr-2007

        60/907,818
	17-Nov-2009	27-Apr-2008

        2008242106
	29-Aug-2013

        2008242106
	Granted	Hadasit
                                         Medical Research Services and Development Ltd.

        IDELSON
        Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak

	47437

        315-02
	Canada

        NP
	18-Apr-2007

        60/907,818
	16-Oct-2009	27-Apr-2008

        2,684,460
	03-Jan-2017

        2,684,460
	Granted	Hadasit
                                         Medical Research Services and Development Ltd.

        IDELSON
        Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak

	47438

        315-05
	Japan

        NP
	18-Apr-2007

        60/907,818
	19-Oct-2009	27-Apr-2008

        2010-503665
	25-Oct-2013

        5,395,058
	Granted	Hadasit
                                         Medical Research Services and Development Ltd.

        IDELSON
        Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan




 



    	Page 2 of 6



    	 



    

 


	METHODS
    OF GENERATING PLURIPOTENT STEM CELL-DERIVED RETINAL PIGMENT EPITHELIAL CELLS  
	Our
                                         Ref

        Client
        Ref
	Country	Earliest
    Priority 	Entry
    Date 	Filing
                                         Date

        Application
        No.
	Publication
                                         Date + No.

        Issue
        Date + Patent No.
	Status	Assignee
                                         Inventor

	47439

        315-06
	Israel

        NP
	18-Apr-2007

        60/907,818
	18-Oct-2009	27-Apr-2008

        201600
	Publ.
                                         Date: 24-Mar-2013

        Publ.
        #: 201600

        25-Jun-2013

        201600
	Granted	Hadasit
                                         Medical Research Services and Development Ltd.

        IDELSON
        Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak

	Our
                                         Ref

        Client
        Ref
	Country	Earliest
    Priority 	Entry
    Date 	Filing
                                         Date

        Application
        No.
	Publication
                                         Date + No.

        Issue
        Date + Patent No.
	Status	Assignee
                                         Inventor

	56027

        315-19
	Israel

        DIV
	18-Apr-2007

        60/907,818
	11-Mar-2013	27-Apr-2008

        225163
	 	Pending	Hadasit
                                         Medical Research Services and Development Ltd.

        IDELSON
        Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak

	47440

        315-07
	China

        NP
	18-Apr-2007

        60/907,818
	18-Dec-2009	27-Apr-2008

        200880020748.0
	Publ.
                                         Date: 31-Mar-2010

        Publ.
        #: 101688178

        04-Dec-2013

        200880020748.0
	Granted	Hadasit
                                         Medical Research Services and Development Ltd.

        IDELSON
        Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak

	57677

        315-13

         
	China

        DIV
	18-Apr-2007

        60/907,818
	16-Oct-2013	27-Apr-2008

        201310484803.4
	Publ.
                                         Date: 05-Feb-2014

        Publ.
        #: CN 103555654 A

        20-Apr-2016

        ZL201310484803.4
	Granted	Hadasit
                                         Medical Research Services and Development Ltd.

        IDELSON
        Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak

	59417

        315-18
	Hong
                                         Kong

        DIV
	18-Apr-2007

        60/907,818
	19-May-2014	27-Apr-2008

        14104657.0
	Publ.
                                         Date: 25-Jul-2014

        Publ.
        #: 1191377A
	Allowed	Hadasit
                                         Medical Research Services and Development Ltd.

        IDELSON
        Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak

	47441

        315-09
	India

        NP
	18-Apr-2007

        60/907,818
	18-Nov-2009	27-Apr-2008

        6790/CHENP/2009
	 	Pending	Hadasit
                                         Medical Research Services and Development Ltd.

        IDELSON
        Masha ; ALPER-PINUS Ruslana ; OBOLENSKY Alex ; BANIN Eyal ; REUBINOFF Benjamin Eithan ; HEMO Yitzchak



 




    	Page 3 of 6



    	 



    


 


Part
II – Hadasit IP


 


	LARGE
    SCALE PRODUCTION OF RETINAL PIGMENT EPITHELIAL CELLS – 
	Our
                                         Ref

        Client
        Ref
	Country	Earliest
    Priority 	Entry
    Date 	Filing
                                         Date

        Application
        No.
	Publication
                                         Date + No.

        Issue
        Date + Patent No.
	Status	Assignee

        Inventor

	62470

        558-00
	USA

        PRO
	 

         
	 	29-Jul-2015

        62/198,160
	 	Expired	Hadasit
                                         Medical Research Services and Development Ltd.

        REUBINOFF
        Benjamin Eithan ; SINGER Orna

	66071

        558-01
	PCT

         
	29-Jul-2015

        62/198,160
	 	28-Jul-2016

        IL2016/050829
	 	Filed	Hadasit
                                         Medical Research Services and Development Ltd.

        REUBINOFF
        Benjamin Eithan ; SINGER Orna



 


	METHODS
    OF PRODUCING PHOTORECEPTOR CELLS FOR THE TREATMENT OF RETINAL DISEASES– 
	Our
                                         Ref

        Client
        Ref
	Country	Earliest
    Priority 	Entry
    Date 	Filing
                                         Date

        Application
        No.
	Publication
                                         Date + No.

        Issue
        Date + Patent No.
	Status	Assignee

        Inventor

	69074

        655-00
	USA

        PRO
	 

         
	 	08-Feb-2017

        62/456,155
	 	Filed	Hadasit
                                         Medical Research Services and Development Ltd.

        Banin
        Eyal, Idelson Masha, Khaner Hanita, Obolensky Alexey, Reubinoff Benjamin E



 


Part
III – Joint IP


 


	METHODS
    OF SELECTING RETINAL PIGMENTED EPITHELIAL CELLS 
	Our
                                         Ref

        Client
        Ref
	Country	Earliest
    Priority 	Entry
    Date 	Filing
                                         Date

        Application
        No.
	Publication
                                         Date + No.

        Issue
        Date + Patent No.
	Status	Assignee

        Inventor

	52753

        485-00
	USA

        PRO
	 	 	31-Jan-2012

        61/592,635
	 	Expired	Cell
                                         Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd.

        REUBINOFF
        Benjamin Eithan ; YACHIMOVICH-COHEN Nurit ; MATZRAFI Limor

	55700

        485-01
	PCT

         
	31-Jan-2012

        61/592,635
	 	29-Jan-2013

        IL2013/050077
	Publ.
                                         Date: 08-Aug-2013

        Publ.
        #: WO2013/114360
	Expired	Cell
                                         Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd.

        REUBINOFF
        Benjamin Eithan ; YACHIMOVICH-COHEN Nurit ; MATZRAFI Limor

	60058

        485-02
	USA

        NP
	31-Jan-2012

        61/592,635
	29-Jul-2014	29-Jan-2013

        14/375,195
	Publ.
                                         Date: 08-Jan-2015

        Publ.
        #: 2015-0010922-A1
	Allowed	Cell
                                         Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd.

        REUBINOFF
        Benjamin Eithan ; YACHIMOVICH-COHEN Nurit ; MATZRAFI Limor

	60059

        485-03
	Canada

        NP
	31-Jan-2012

        61/592,635
	29-Jul-2014	29-Jan-2013

        2,863,172
	 	Pending	Cell
                                         Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd.

        REUBINOFF
        Benjamin Eithan ; YACHIMOVICH-COHEN Nurit ; MATZRAFI Limor

	60060

        485-04
	Australia

        NP
	31-Jan-2012

        61/592,635
	15-Aug-2014	29-Jan-2013

        2013216382
	 	Pending	Cell
                                         Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd.

        REUBINOFF
        Benjamin Eithan ; YACHIMOVICH-COHEN Nurit ; MATZRAFI Limor

	69345

        485-05
	US

        DIV
	31-Jan-2012

        61/592,635
	15-Aug-2014	28-Mar-2017

        15/470,926
	 	Pending	Cell
                                         Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd.

        REUBINOFF
        Benjamin Eithan ; YACHIMOVICH-COHEN Nurit ; MATZRAFI Limor



 




    	Page 4 of 6



    	 



    


 


	HIGH
    THROUGHPUT SCREENING OF AGENTS ON HUMAN PLURIPOTENT-DERIVED DOPAMINERGIC NEURONS 
	Our
                                         Ref

        Client
        Ref
	Country	Earliest
    Priority 	Entry
    Date 	Filing
                                         Date

        Application
        No.
	Publication
                                         Date + No.

        Issue
        Date + Patent No.
	Status	Assignee

        Inventor

	55925

        496-00
	USA

        PRO
	 	 	13-Feb-2013

        61/764,031
	 	Expired	Cell
                                         Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd.

        MORDECHAI
        DANIEL Talya ; WISER Ofer ; REUBINOFF Benjamin Eithan

	HIGH
    THROUGHPUT SCREENING OF AGENTS ON DOPAMINERGIC NEURONS 
	Our
                                         Ref

        Client
        Ref
	Country	Earliest
    Priority 	Entry
    Date 	Filing
                                         Date

        Application
        No.
	Publication
                                         Date + No.

        Issue
        Date + Patent No.
	Status	Assignee

        Inventor

	55931

        496-01
	USA

        PRF
	13-Feb-2013

        61/764,031
	 	18-Mar-2013

        61/802,814
	 	Expired	Cell
                                         Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd.

        MORDECHAI
        DANIEL Talya ; WISER Ofer ; REUBINOFF Benjamin Eithan

	58434

        496-02
	PCT

         
	13-Feb-2013

        61/764,031
	 	12-Feb-2014

        IL2014/050149
	Publ.
                                         Date: 21-Aug-2014

        Publ.
        #: WO2014/125481
	Expired	Cell
                                         Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd.

        MORDECHAI
        DANIEL Talya ; WISER Ofer ; REUBINOFF Benjamin Eithan

	63486

        496-03
	Europe

        NP
	13-Feb-2013

        61/764,031
	28-Aug-2015	12-Feb-2014

        14751359.2
	Publ.
                                         Date: 23-Dec-2015

        Publ.
        #: 2956539
	Pending	Cell
                                         Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd.

        MORDECHAI
        DANIEL Talya ; WISER Ofer ; REUBINOFF Benjamin Eithan

	65929

        496-06
	Hong
                                         Kong

        NP
	13-Feb-2013

        61/764,031
	13-Apr-2016	12-Feb-2014

        16104232.2
	Publ.
                                         Date: 28-Oct-2016

        Publ.
        #: 1216258A
	Pending	Cell
                                         Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd.

        MORDECHAI
        DANIEL Talya ; WISER Ofer ; REUBINOFF Benjamin Eithan

	63487

        496-04
	USA

        NP
	13-Feb-2013

        61/764,031
	10-Aug-2015	12-Feb-2014

        14/766,784
	Publ.
                                         Date: 31-Dec-2015

        Publ.
        #: 2015-0377864-A1
	Pending	Cell
                                         Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd.

        MORDECHAI
        DANIEL Talya ; WISER Ofer ; REUBINOFF Benjamin Eithan

	63488

        496-05
	Israel

        NP
	13-Feb-2013

        61/764,031
	06-Aug-2015	12-Feb-2014

        240415
	 	Pending	Cell
                                         Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd.

        MORDECHAI
        DANIEL Talya ; WISER Ofer ; REUBINOFF Benjamin Eithan

	66894

        496-07
	Canada

        NP
	13-Feb-2013

        61/764,031
	11-Jul-2016	12-Feb-2014

        2,936,486
	 	Pending	Cell
                                         Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd.

        MORDECHAI
        DANIEL Talya ; WISER Ofer ; REUBINOFF Benjamin Eithan

	

        PREPARATION
        OF RETINAL PIGMENT EPITHELIUM CELLS 

	Our
                                         Ref

        Client
        Ref
	Country	Earliest
    Priority 	Entry
    Date 	Filing
                                         Date

        Application
        No.
	Publication
                                         Date + No.

        Issue
        Date + Patent No.
	Status	Assignee

        Inventor

	64082
                                         603-00
	USA
                                         PRO
	 	 	26-Oct-2015

                                                                                                                        62/246,214
	 	Expired	Cell
                                         Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd.

        REUBINOFF
        Benjamin Eithan ; SINGER Orna

	67196

        603-01
	PCT

         
	26-Oct-2015

        62/246,214
	 	26-Oct-2016

        IL2016/051155
	 	Filed	Cell
                                         Cure Neurosciences Ltd. ; Hadasit Medical Research Services and Development Ltd.

        REUBINOFF
        Benjamin Eithan ; SINGER Orna ; BOHANA-KASHTAN Osnat ; WISER Ofer



 



    	Page 5 of 6



    	 



    

 


Part
IV – OCS Funded 


 


	METHODS
    OF TREATING RETINAL DISEASES 
	Our
                                         Ref

        Client
        Ref
	Country	Earliest
    Priority 	Entry
    Date 	Filing
                                         Date

        Application
        No.
	Publication
                                         Date + No.

        Issue
        Date + Patent No.
	Status	Assignee

        Inventor

	61895

        602-03
	PCT

         
	30-Dec-2014

        62/097,753
	 	30-Apr-2015

        IL2015/050456
	Publ.
                                         Date: 07-Jul-2016

        Publ.
        #: WO2016/108219
	Published	Cell
                                         Cure Neurosciences Ltd.

        BANIN
        Eyal ; REUBINOFF Benjamin Eithan ; BOHANA-KASHTAN Osnat ; NETZER Nir ; IRVING Charles Sherard



 



    	Page 6 of 6