|Exhibit 3.4


AMENDMENT NUMBER TWO
TO THEAMENDED AND RESTATEDCERTIFICATE
OF INCORPORATIONOFVAXGEN, INC.


VAXGEN, INC.,a corporation
organized and existing under the General Corporation Law of the State of Delaware:


DOES HEREBY CERTIFY:


FIRST:That, in accordance
with Section 141 of the General Corporation Law of the State of Delaware, in a meeting of
the Board of Directors of VaxGen, Inc., resolutions were duly adopted setting forth a
proposed amendment of the Amended and Restated Certificate of Incorporation of said
corporation, declaring said amendment to be advisable and calling for consideration
thereof by the stockholders of said corporation. The resolution setting forth the proposed
amendment is as follows:
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | RESOLVED,by the Board of Directors of the Company that Article 4, Section 4.1 of the Companys
Amended and Restated Certificate of Incorporation is hereby proposed to be amended to
read as follows:
| | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | The
total number of shares of stock that the corporation is authorized to issue is 85,000,000
consisting of 65,000,000 shares of common stock, par value $0.01 per share, and 20,000,000
shares of preferred stock, par value $0.01 per share. The common stock will be subject to
the rights and preferences of the preferred stock as set forth in this Amended and
Restated Certificate of Incorporation and the resolution or resolutions providing for the
issue of any such stock adopted by the Board of Directors.
| | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|SECOND:That thereafter,
pursuant to resolution of its Board of Directors, the proposed amendment was submitted to
the stockholders of said corporation for their consideration and was duly adopted and
approved, in accordance with Section 242 of the General Corporation Law of the State of
Delaware, at a special meeting of the stockholders.


THIRD:That said amendment was
duly adopted in accordance with the provisions in Section 242 of the General Corporation
Law of the State of Delaware.


IN WITNESS WHEREOF,said
VaxGen, Inc. has caused this certificate to be signed by Lance K. Gordon, its President,
and Kevin C. Lee, its Secretary, this 10th day of August, 2005.
|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

By:/s/ Lance Gordon
             Lance K. Gordon

Attest:/s/ Kevin Lee
                  Kevin C. Lee


|1
|-