Ferric Phosphate, Monopotassium Phosphate, Dipotassium Phosphate PC Code: 034903, 076413, 176407

**UNITED STATES ENVIRONMENTAL PROTECTION AGENCY**

**MEMORANDUM SUBJECT**  : Product Chemistry Scoping Document for the Registration Review o Monopotassium Phosphate, **Registration Review Case #: PC Code:**  **CAS Numbers: Chemical Class:**  **FROM:** Angela L. Gonzales, Biologist

Biochemical Pesticides Branch Biopesticides & Pollution Prevention Division (7511P) **TO :**  Leonard Cole, Senior Regulatory Specialist Biochemical Pesticides Branch Biopesticides & Pollution Prevention Division (7511P)

**ACTION REQUESTED** The following scoping document contains the product chemistry assessmen phosphate , monopotassium phosphate and Registration Review Work Plan. **Executive Summary** The Agency has made the determination that product chemistry information available on phosphate. While the information on file is adequate applications, more data and/or information for certain data requirements for these chemicals should be submitted . The data requirements that should be further addressed are discussed below for each chemical. Phosphate, Monopotassium Phosphate, Dipotassium Phosphate Case Product Chemistry

**UNITED STATES ENVIRONMENTAL PROTECTION AGENCY**

**WASHINGTON, D.C. 20460**
September 6, 2012 **OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION** Product Chemistry

Scoping Document for the Registration Review o f Ferric Monopotassium Phosphate, and Dipotassium Phosphate
. **6072 034903, 076413, 176407**  **100045 -**  **86 -**  **0 , 7778**  **- 77**  **- 0**  **, 7758**  **Biochem ical**  Biologist Biochemical Pesticides Branch Biopesticides & Pollution Prevention Division (7511P) Leonard Cole, Senior Regulatory Specialist Biochemical Pesticides Branch Biopesticides & Pollution Prevention Division (7511P)

The following scoping document contains the product chemistry assessmen t for the biopestici

, monopotassium phosphate and dipotassium phosphate in support of the development of the

has made the determination that for the purposes of registration review, there is adequate information available on ferric phosphate, monopotassium phosphate and dipotassium While the information on file is adequate for registration review, for future pesticide applications, more data and/or information for certain data requirements for these chemicals should be . The data requirements that should be further addressed are discussed below for each Case #: 6072 Product Chemistry

—Registration Review

**OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION**

Ferric Phosphate ,

**7758 -**  **11 -**  **4**

t for the biopestici des ferric in support of the development of the

there is adequate ferric phosphate, monopotassium phosphate and dipotassium

review, for future pesticide applications, more data and/or information for certain data requirements for these chemicals should be . The data requirements that should be further addressed are discussed below for eachFerric Phosphate, Monopotassium Phosphate, Dipotassium Phosphate Case #: 6072 PC Code: 034903, 076413, 176407 Product Chemistry

—Registration Review **Introduction** Ferric Phosphate As a pesticide, ferric phosphate is used as a molluscicide (specificall y, slugs and snails) on and around a variety of ornamental and food crops. The active ingredient was first registered in 1997. There are currently two products registered containing the active ingredient, all of which are end

-use products ( EPs). One product contains ferric phosphate as the only active ingredient and the other product contains the biopesticide in conjunction with a conventional chemical (spinosad). The chemical is not approved for use as an inert ingredient in pesticide formulations at this time. Monopotassium Phosphate As a pesticide, monopotassium phosphate is used as a fungicide on a variety of ornamental and food crops. The active ingredi ent was first registered in 1994
. There are currently four products registered containing th e active ingredient, all of which are EP s . Two of the products contain the active ingredient in conjunction with a conventional chemical (sulfur), one product contains the active ingredient in conjunction with another biopesticide (mono

- and di

- potassium salts of phosphorous acid) and the last product contains monopotassium phosphate as the onl y active ingredient. The chemical is approved for use as an inert ingredient in pesticide formulations for both nonfood and food (40 CFR § 180.910 and 180.920) uses
. Dipotassium Phosphate As a pesticide, dipotassium phosphate is used as a fungicide on a variety of ornamental and food crops. The active ingredient was first registered in 2002. There is currentl y one product registered containing the active ingredient; an EP which contains the chemical in conjunction with another biopesticide (mono

- and di

potassium salts of phosphorous acid). The chemical is approved for use as an inert ingredient in pesticide formulations for both nonfood and food (40 CFR § 180.920) uses. **Product Chemistry Summary**  Ferric Phosphate Concerning the product chemistry of ferric phosphate , most biochemical pesticide data requirements for the technical grade active ingredient have been satisfied and are summarized in Table 1 and Table 2. While the information on file is adequate for the purposes of registration review, for future pesticide applications , data on the partition coefficient of the chemical must be submitted according to OCSPP Guidelines 830.7550

- 7570 and more specific data on the stability of the chemical should be submitted according to OCSPP Guideline 830.6313
.Ferric Phosphate, Monopotassium Phosphate, Dipotassium Phosphate Case #: 6072 PC Code: 034903, 076413, 176407 Product Chemistry

—Registration Review

3 **Table 1**  **. Product Identity and Composition for Ferric**  **Phosphate Common Name**  Iron (III) phosphate; ferric phosphate ; ferric orthophosphate **Chemical Name, IUPAC** Phosphoric acid, iron 3 + salt (1:1) **Molecular Weight** 1 50.82 **PC Code** 0 34903 **CAS Registry Number** 10045
- 86
- 0 **Molecular Formula**  Fe O 4 P **Registration Review Case Number** 6072 **Chemical Structure**

The Agency

has conducted a review of the available product chemistry data and information. These data are summarized below. **Table 2**  **. Biochemical Pesticides Product Chemistr y Data Requirements**  **for Ferric Phosphate**  **Guideline No.**  **Physical and Chemical**

**Properties Status**  **1 Value**  **MRID 830.1100**  Product Identity and Composition A Refer to Table 1. 44073401 44732201 **830.1200** Description of starting

materials, production and formulation process A Confidential Business In formation (CBI) 44073401 44732201 **830.1400** Discussion of formation of

impurities A CBI 44732201 **830.1700** Preliminary anal ys is A CBI 44042701 44131901 46811902Ferric Phosphate, Monopotassium Phosphate, Dipotassium Phosphate Case #: 6072 PC Code: 034903, 076413, 176407 Product Chemistry

—Registration Review

4 **830.1800** Enforcement anal ytical

method A CBI 44042701 44131901 44732202 46811902 48741601 **830.6302** Color A White to buff 44042703 **830.6303** Physical state A Dry powder 44042703 **830.6304** Odor A Odorless 44042703 **830.6313** Stability

to normal and elevated temperatures, metals and metal ions A Stable. **More specific data should**  **be provided to support future registrations**  **(refer to**  **OCSPP Guideline 830.6313**  **) .**  44042703

**830.7000** pH N/A Not applicable; chemical is not soluble in water. 44042703 **830.7050** UV/Visible light absorption N/A Data are not necessary to inform the risk assessment. **830.7200** Melting point/melting range N/D Does not melt; degrades into ferric oxide at temperatures near 500oC 44042703
**830.7220** Boiling point/boiling range N/A Not applicable; chemical is not a liquid at room temperature **830.7300** Density A 1 g/ml or 60 lb/ft 3 (bulk density) 44042703 **830.7520** Particle size, fiber length, and

diameter distribution A 3 microns (per MSDS) 44070601 **830.7550 830.7560**  **830.7570** Partition coefficient (n

Octanol/Water) N/A Not applicable; chemical is an organic compound **830.7840** Water solubility A Insoluble in water 44042703 **830.7950** Vapor pressure N/A Not applicable; chemical is a non - volatile solid 44042703
1 A=Acceptable. N/A=Not Applicable. N/D=Not Determined.
Monopotassium PhosphateFerric Phosphate, Monopotassium Phosphate, Dipotassium Phosphate Case #: 6072 PC Code: 034903, 076413, 176407 Product Chemistry

—Registration Review

5 Concerning the product chemistry of monopotassium phosphate, most biochemical pesticide data requirements for the technical grade active ingredient have been satisfied and are summarized in Table 3 and Table 4 . While the information on file is adequate for the purposes of registration review, for future pesticide applic ation s, more specific data on the stability of the chemical should be submitted according to OCSPP Guideline 830.6313. **Table 3 . Product Identity and Composition for**  **Monopotassium Phosphate Common Name**  Monopotassium p hosphate ; phosphoric acid, monopotassium salt; potassium phosphate, monobasic **Chemical Name, IUPAC** Potassium dihydrogen phosphate **Molecular Weight** 136.09 **PC Code** 076413 **CAS Registry Number** 7778
- 77
- 0 **Molecular Formula**  H 2 KO 4 P **Registration Review Case Number** 6072 **Chemical Structure**

The Agency

has conducted a review of the available product chemistry data and information. These data are summarized below. **Table 4 . Biochemical Pesticides Product Che**  **mi str** **y Data Requirements for Monopotassium Phosphate Guideline**  **Physical and Chemical Status**  **1 Value**  **MRID**Ferric Phosphate, Monopotassium Phosphate, Dipotassium Phosphate Case #: 6072 PC Code: 034903, 076413, 176407 Product Chemistry

—Registration Review

6 **No. Properties**  **830.1100** Product Identity and Composition A Refer to Table 3
. 44234201 **830.1200** Description of starting

materials, production and formulation process A CBI 44234201
**830.1400** Discussion of formation of

impurities A CBI 44234201 **830.1700** Preliminary anal ys is A CBI 44234201 **830.1800** Enforcement anal ytical

method A CBI **830.6302** Color A White 44234201 **830.6303** Physical state A Crystalline solid 44234201 **830.6304** Odor A No characteristic odor 44234201 **830.6313** Stability

to normal and elevated temperatures, metals and metal ions A Stable **More specific data should be provided to support**  **future registrations (refer**  **to OCSPP Guideline 830.6313).**  44234201

**830.7000** pH A 4.5 (1% solution) 44234201 **830.7050** UV/Visible light absorption N/A Data are not necessary to inform the risk assessment. **830.7200** Melting point/melting range A 25 3oC HSDB 2 **830.7220** Boiling point/boiling range N/A Not applicable; chemical is not a solid at room temperature **830.7300** Density A 1.3 g/cm 3 2.3 g/cm 3 44234201 HSDB 2 **830.7520** Particle size, fiber length, and

diameter distribution N/A Not applicable; chemical is not water insoluble and fibrous with a diameter ≥ 0.1μm **830.7550 830.7560**  **830.7570** Partition coefficient (n

Octanol/Water) N/A Not applicable; data are not required for chemicals that are soluble in water. **830.7840** Water solubility A Soluble 25g/100ml water 44234201 HSDB 2Ferric Phosphate, Monopotassium Phosphate, Dipotassium Phosphate Case #: 6072 PC Code: 034903, 076413, 176407 Product Chemistry

—Registration Review

7 **830.7950** Vapor pressure N/A Not applicable; chemical is a non - volatile solid 1 A=Acceptable. N/A=Not Applicable. N/D=Not Determined. 2 Hazardous Substances Data Bank, 2012. Dipotassium Phosphate Concerning the product chemistry of dipotassium phosphate, most biochemical pesticide data requirements for the technical grade active ingredient have been satisfied and are summarized in Table 5 and Table 6 . While the information on file is adequate for the purposes of registration review, for future pesticide applic ation s, more specific data on the stability of the chemical should be submitted according to OCSPP Guideline 830.6313 and more specific data on the solubility of the chemical should be submitted according to OCSPP Guideline 830.7840
. **Table 5 . Product I**  **de ntity and Composition for Di** **potassium Phosphate Common Name**  Dipotassium phosphate ; phosphonic acid, dipotassium salt ; potassium phosphate, dibasic **Chemical Name, IUPAC** dipotassium monohydrogen phosphate **Molecular Weight** 174
. 18 **PC Code** 176407 **CAS Registry Number**  7758
- 11
- 4 **Molecular Formula**  HK2 O 4 P **Registration Review Case Number** 6072 **Chemical Structure**Ferric Phosphate, Monopotassium Phosphate, Dipotassium Phosphate Case #: 6072 PC Code: 034903, 076413, 176407 Product Chemistry

—Registration Review

8 The Agency

has conducted a review of the available product chemistry data and information. These data are summarized below. **Table 6 .**  **Biochemical Pesticides Product Chem istry Data Requirements for Di** **potassium Phosphate Guideline**  **No. Physical and Chemical** 

**Properties Status**  **1 Value**  **MRID 830.1100**  Product Identity and Composition A Refer to Table 1. 44815001 **830.1200** Description of starting

materials, production and formulation process A CBI 44815001
**830.1400** Discussion of formation of

impurities A CBI 44815001 **830.1700** Preliminary anal ys is A CBI 44815001 **830.1800** Enforcement anal ytical

method A CBI 44815004 **830.6302** Color A White Merck Index 2 **830.6303** Physical state A Granules/crystals Merck Index 2 **830.6304** Odor N/D No characteristic odor MSDS 4 **830.6313** Stability

to normal and elevated temperatures, metals and metal ions A Stable **More specific data should be**  **provided to support future registrations**  **(r efer**  **to OCSPP Guideline 830.6313**  **).** MSDS 4

**830.7000** pH A 8.8 (1% solution) HSDB 3 **830.7050** UV/Visible light absorption N/A Data are not necessary to inform the risk assessment **830.7200** Melting point/melting range A 340oC MSDS 4 **830.7220** Boiling point/boiling range A Not applicable; chemical is not a liquid at room temperature **830.7300** Density A 2.30 g/cm 3 MSDS 4 **830.7520** Particle size, fiber length, and

diameter distribution N/A Not applicable; chemical is not water insoluble and fibrous with a diameter ≥ 0.1μmFerric Phosphate, Monopotassium Phosphate, Dipotassium Phosphate Case #: 6072 PC Code: 034903, 076413, 176407 Product Chemistry

—Registration Review

9 **830.7550 830.7560**  **830.7570** Partition coefficient (n

Octanol/Water) N/A Not applicable; data are not required for chemicals that are soluble in water. **830.7840** Water solubility A Soluble **More specific data should be provided to support**  **future registrations (r**  **efer to OCSPP Guideline**  **830.7840 ).**  MSDS 4

**830.7950** Vapor pressure N/A Not applicable; chemical is a non - volatile solid. 1 A=Acceptable. N/A=Not Applicable. N/D=Not Determined. 2 The Merck Index, 2012 3 HSDB, 2012 4 MSDS, 2012

**References** Hazardous Substances Data Bank (HSDB)
. United States National Library of Medicine, Online. 0 9/04/12
. < http://www.toxnet.nlm.nih.gov/cgi

-bin/sis/search> Material Safety Data Sheet (MSDS) for Potassium Phosphate, Dibasic. Sigma

- Aldrich. Online. 09/06/12. < http://www.sigmaaldrich.com> The Merck Index Online. 14 th Edition. EPA Library Search. 09/05/12. < http://library .dialog.com/bluesheets/html/bl0304.html >