Fluoxastrobin 028869 Dietary Exposure and Risk Assessment DP Number: 380847

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### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION 

### MEMORANDUM DATE: 12 /2 8 /20 10 SUBJECT: Fluoxastrobin: Chronic Dietary (Food and Drinking Water) Exposure

Assessments for the Section 3 Registration Action u se on Squash/Cucumber Subgroup 9B. PC Code: 028869 DP Barcode: 3 80847 Decision No.: 433137 Registration No. : 66330 - 64 Petition No.: NA Regulatory Action: Section 3 Registration Risk Assessment Type: Dietary Case No.: N A T XR No.: NA CAS No.: 361377 - 29 - 9 MRID No.: NA 40 CFR: § 

### 180. 609 REVI EWER: Cassi L. Walls, Ph.D , Senior Biologist

Risk Assessment Branch III Health Effects Division (7509P) THROUGH: Mohsen Sahafey an , Chemist

Donna Davis, Chemist Dietary Exposure Science Advisory Council (DESAC) Health Effects Division (7509P) TO: Nancy

Tsaur , Risk Assessor Risk Assessment Branch III Health Effects Division (7509P ) Tony Kish, RM Team #22 Registration Division (7505P) Executive Summary C hronic dietary (food and drinking water) exposure and risk assessments were conducted using the Dietary

Exposure Evaluation M odel (DEEM - FCIDTM, Version 2.03 ) , which use s food consumption data from the U.S. Department of Agriculture’s Continuing Survey s of Food Intakes by Individuals (CSFII) from 1994 - 1996 and 1998. The anal ys es were performed to support new uses on crop subgroup 9B.Fluoxastrobin 028869 Dietary Exposure and Risk Assessment DP Number: 380847

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### Acute Dietary

Exposure Results and Characterization : No toxic effects attributable to a single exposure to fluoxastrobin have been identified; therefore, an acute reference dose (aRfD) has not bee n established and an acute dietary exposure assessment was not conducted. Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization A conservative dietary

exposure assessment was performed for fluoxastrobin. The assumptions of this dietary assessment included tolerance level residues and 100% crop treated (CT) . Estimated drinking water concentration (EDWC) values were also incorporated. The estimated surface water concentration was incorporated directly into the dietary

assessment us ing the 1 - in - 10 y r annual mean of 5 3 μ g/ L ( DP 379114, 384377 ) . The results of the c hronic dietary anal ys is for f

ood and drinking water are below the Agency ’s level of concern for all population subgroups. T he dietary exposure for food and water is estimated at 22 % of the c hronic Population Adjusted Dose (cPAD) for the general U.S. population and 47 %, of the cPAD for children 1 - 2 y rs, the population subgroup with the highest estimated chronic dietary exposure to fluoxastrobin . Canc er Dietary

Exposure Results and Characterization The Cancer Assessment Review Committee ( CARC ) recentl y concluded that fluoxastrobin is “not likely to be carcinogenic to humans ; ” therefore , cancer risk is no t of concern . I. Introduction Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse h ealth effects). This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to the reference do se point of d eparture ( PO D , NOAEL , LOAEL ) divided by

the required uncertaint y and s afet y f actor s . For acute and non - cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk exceeds one in one million. References which discuss the acute and chronic risk assess ments in more detail are available on the EPA/pesticides web site: “Available In formation on Assessing Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link: http://www .epa.gov/fedrgstr/EPA - PEST/2000/July /Day - 12/6061.pdf

; or see SOP 99.6 (8/20/99). The last dietary risk assessment for fluoxastrobin was conducted b y M. Negussie ( 01/22/2010 , DP 3 67050 ). This dietary assessment is an update to the January 2010Fluoxastrobin 028869 Dietary Exposure and Risk Assessment DP Number: 380847

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### fluoxa strobin dietary

assessment to include the proposed new uses on squash/cucumber Subgroup 9B . II. Residue Information Fluoxastrobin is a fungicide used for the control of fungal diseases in tuberous and corm vegetables, fruiting vegetables, the leaf petiole vegetables, peanuts, sweet corn, wheat, as a seed treatment for potato and peanut, and as a soilborne/seedling disease control. Th e residues of concern in primary crops, rotational crops , and livestock, for tolerance enforcement and risk assessment are as follows: primary crops/rotational crops fluoxastrobin and its Z

- isomer , livestock - fluoxastrobin , its Z - isomer and 6 - (2 - chlorophenox y) - 5 - fluoro - 4 - py rimidinol ( D P 289106, W. Wassel l , 01/25/20 05 ) . Table 1 is a summary

of the current food tolerances, T able 2 is a summary of pending tolerances , and Table 3 is a summary of the proposed tolerances for fluoxastrobin. As st ated above, Ary sta is request ing the establishment of tolerances for fluoxastrobin for the new use on squash/cucumber Subgroup 9B . HED recommends a food tolerance 0.50 ppm for residues of fluoxastrobin resulting from the proposed ne w use on squash/cucumbers (DP 380846, M. Negussie, 11/17/2010). TABLE 1 . Summary of Current Tolerance s for Fluoxastrobin Comm odity Tolerance (ppm) 40 CFR §180.609(a)(1) Berry, low

growing, subgroup 13 - 07G 1.9 Leaf petioles, subgroup 4B 4.0 Soy bean seed 0.05 Tomato paste 1.5 Vegetable, fruiting, group 8 1.0 Vegetable, tuberous and corm, subgroup 1C 0.01 40 CFR §180.609(a)(2) Cattle, fat Goat, fat Horse, fat Sheep, fat 0.10 Cattle, meat Goat, meat Horse, meat Sheep, meat 0.05

Milk 0.02 Milk, fat 0.50Fluoxastrobin 028869 Dietary Exposure and Risk Assessment DP Number: 380847

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Page 4 of 13 TABLE 2 . Summary of Pending Tolerance for Fluoxastrobin Comm odity Tolerance (ppm) 40 CFR §180.609(a)(1) Corn, s weet , kernels plus cobs with husks removed ( K+CWHR) 0.0 1 Wheat, grain 0.09 Wheat, bran 0. 15 Peanut * 0.02 P eanut, refined oil * 0.06 40 CFR §180.609(a)(2) Cattle, meat byproducts * Goat, meat byproducts Horse, meat byproducts Sheep, meat byproducts 0.20


### * Note that the current 40 CFR §180.609(a)(1) and (2) lists different tolerances for these commodities. The tolerances listed in this table differ because the registrant provided additional data and requested tolerances for new uses that can be fed to livestock which affected the livestock commodity residue s. These tolerances are still pending. Detailed information on these data can be found in the previous dietary assessment (DP367050, M. Negussie, 01/22/2010) . TABLE 3 . Summary of Proposed Tolerance for Fluoxastrobin Comm odity Tolerance (ppm) 40 CFR §180.609(a)(1) Squash/cucumber Subgroup 9B 0.50 

### Residue Data used for Chronic Assessments: Current, pending, and proposed t olerance level residues and 100% CT were used for all commoditi es included in the assessment. Based on processing studies, the processing factors for tomato puree, potato , chips, dried potato (granules/flakes), and potato, flour were reduced to 1 . Separate tolerances were set for peanut oil , wheat bran and tomato paste; therefore, the processing factors for these commodities were set at 1 ( DP 289106 , W.D. Wassell, 01/25/2005 ). For all other processed commodities, DEEM version 7.81 default processing factors were assumed. Residue values used for c hro nic assessments are listed in Table s 1, 2, and 3 while the processing factors are listed in Table 4 . TABLE 4 . Processing Factors (PF) for Fluoxastrobin Dietary Risk Assessment. 

### Processed Commodity PF Source Beef, meat, dried 1.92 DEEM Default Corn grain, sugar/hfcs 1.5 DEEM Default Cranberries, j uice 1.1 DEEM Default Peanut, butter 1.89 DEEM Default Peanut, oil 1.0 Tolerance for p eanut , oil accounts for processing .Fluoxastrobin 028869 Dietary Exposure and Risk Assessment DP Number: 380847

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Page 5 of 13 TABLE 4 . Processing Factors (PF) for Fluoxastrobin Dietary Risk Assessment. Potato , dried and f

lour 1.0 Processing Study Tomato, dried 14.3 DEEM Default Tomato, juice 1. 5 DEEM Default Tomato , p aste 1.0 Tolerance for t omato, paste accounts for processing . Tomato , p uree 1.0 Processing Study Wheat, bran 1.0 Tolerance for wheat, bran accounts for processing. 

### III. Drinking Water Data The drinking water residues used in the dietary risk assessment were provided by the Environmental Fate and Effects Division ( EFED ) ( DP 379114 and 384377 , R. Bohat y, 12/15/10 ) and incorporated directl y into this dietary assessment. Water residues were inco rporated in the DEEM - FCID into the food categories “water, direct, all sources” and “w ater, indirect, all sources.” Tier II EDWCs in surface water were estimated using PRZM/EXAMS while Tier I EDWCs in groundwater were estimated using the SCI - GROW Model . T he chronic Tier I I EDWCs for the new use on squash/cucumbers are significantl y lower ( 1 2 μ g/ L ) than the exposures calculated base d on the revised existing fluoxastrobin use on turf (5 3 μ g/ L). The revised turf use prov ided the most conservative EDWC and w as used in this assessment . F luoxastrobin EDWCs were estimated using the turf us e based on an application interval of 7 day s and total application rate of 2.2 lb ai/A resulting from 4 applications of 0.55 lb ai/A. The currently approved label and the proposed label for fluoxastrobin allow for a 7 day application interval on turf . Table 5 provides an updated Tier I I EDWCs for turf in surface water. In the chronic anal ys is, the 1 - in 10 y ear peak surface water value of 53 ppb was used. The models and their descriptions are available at the EPA i nternet site: http://www.epa.gov/oppefed1/models/water/ . TABLE 5 . Tier I I EDWCs of Fluoxastrobin in surface wat er.
Crop Scenario PR Z M/EXAMS Estimated Co ncentrations in Surface Water ( 

### μ g/L) 1 - in - 10 y ear Annual Peak (Acute) 1 - in - 10 y ear Annual Mean (Chronic) 30 year annual mean (Cancer) Turf use 60.7 52.9 23.5 

### IV. DEEM - FCIDTM Program and Consumption Information Fluoxa strobin chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM - FCIDTM, Version 2.03 ), which incorporates consumption data from USDA’s Continuing Survey s of Food Intakes by Individuals (CSFII), 1994 - 1996 and 1998. TheFluoxastrobin 028869 Dietary Exposure and Risk Assessment DP Number: 380847

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### 1994 - 96, 98 data are based on the reported consumption of more than 20,000 individuals over two non - consecutive survey da ys . Foods “as consumed” (e.g., apple pie) are linked to EPA - defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicl y available recipe translation files developed jointl y b y USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events. Based on analy sis of th e 1994 - 96, 98 CSFII consumption data, which took into account dietary

patterns and survey

respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1 - 2, children 3 - 5, children 6 - 12, youth 13 - 19, adults 20 - 49, females 13 - 49, and adults 50+ ye ars old. F or chronic dietary

exposure assessment, an estimate of the residue level in each food or food - form (e.g., orange or orange juice) on the food c ommodity residue list is multiplied by the average dail y consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all o ther food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day

and as a percent of the cPAD. This procedure is performed for each population s ubgroup. V. Toxicolog ical Information The toxicity

endpoints pertinent for human dietary risk assessment are summarized in Table 6 . T ABLE 6 . Summary of Toxicological Doses and Endpoints for Fluoxastrobin for Use in Dietary Exposure Risk Assessments Exposure/ Scenario Dose Used in Risk Assessment, UF FQPA SF and

Endpoint for Risk Assessment Study and Toxicological

Effects Ac ute Dietary (General Population) No acute endpoint was identified for the general population. Ac ute Dietary (Females 13 - 49 years of age) No acute endpoint was identified for females 13 to 49 years old. Chronic Dietary all Populations NOAEL = 1.5

mg/kg/day UF = 100 Chronic RfD = 0.015 mg/kg/day FQPA SF = 1X cPAD = chronic RfD FQPA SF = 0.015 mg/kg/day Chronic toxicity study with

dogs. LOAEL = M/F:8.1/7.7 mg/kg/day based on body weight reductions and hepatocytomegaly and cy toplasmic changes associated with increased serum liver alkaline phosphatase indicative of cholestasis. Cancer (oral, dermal, inhalation) Classification: Not likely to be carcinogenic to humans.Fluoxastrobin 028869 Dietary Exposure and Risk Assessment DP Number: 380847

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Page 7 of 13 NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainity factor. FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose. 

### VI. Results/Discussion As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM - FCIDTM anal ys es estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table 7 are for the general U.S. Population, all infants (<1 y ear old), children 1 - 2, children 3 - 5, children 6 - 12, youth 13 - 19, females 13 - 49, adults 20 - 49, and adults 50+ ye ars . Results of Chronic Dietary Exposure Analy sis The results of the aggregate chronic dietary anal ysis for food and drinking water are below the Agency ’s level of concern (<100% cPAD) for the general U.S. population ( 19 % cPAD) and all population subgroups. The most highly exposed population subgroup is children 1 - 2 y rs at 47 % of the cPAD. The results of the chronic dietary exposure anal ys e s are reported in Table 7 below.
Table 7 . Result of Acute and Chronic Dietary Exposure and Risk Estimates for Fluoxastrobin Population Subgroup PAD, mg/kg/day DEEM - FCID (food only) DEEM - FCID (food and water)

Exposure, mg/kg/day % PAD Exposure, mg/kg/day %PAD Chronic Dietary Estimates U.S. Population

0.015 0.002154 14 0.003269 2 2 All infants (< 1 yr) 0.001470 9.8 0.005125 3 4 Children 1 - 2 yrs 0.005323 3 6 0.006979 4 7 Children 3 - 5 y

rs 0.004553 30 0.006103 4 1 Children 6 - 12 y

rs 0.003055 20 0.004125 2 8 Youth 13 - 19 y

rs 0.001914 1 3 0.002720 18 Adults 20 - 49 y

rs 0.001780 1 2 0.002821 1 9 Adults 50+ yrs 0.001749 1 2 0.002844 19 Females 13 - 49 y

rs 0.001728 1 2 0.002765 18 

### Cancer Dietary

Exposure Results and Characterization As noted above, the HED CARC has recentl y revisited the cancer classification for fluoxa strobin. HED has reclassified fluoxa strobin as “not likely to be carcinogenic to humans ,” therefore cancer risk is not of concern . VIII. Characterization of Inputs/Outputs The chronic dietary

risk assessment is conservative . F or this asses sment, tolerance level residues and 100% CT were incorporated in the dietary analy ses. Based on processingFluoxastrobin 028869 Dietary Exposure and Risk Assessment DP Number: 380847

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### studies, the processing factors for tomato puree, potato , chips, dried potato (granules/flakes), and potato, flour were reduced to 1. Separate tolerances were set for peanut oil , wheat bran and tomato paste; therefore, the processing factors for these commodities were set at 1. For all other processed commodities, DE EM version 7.81 default processing factors were assumed . The assessment can be refined using percent crop treated information and monitoring data, however, since there are no risks of concern, additional refinement was not required. Estimated drinking water concentrations for surface water were also incorporated . T he contribution of residues in drinking water to the dietary risk is minimal . IX. Conclusions Dietary risks for fluoxa strobin are below HED’s level of concern for dietary exposure and risk. Children 1 - 2 ye ars old are the most highly exposed popul ation subgroup for chronic exposure, with risks estimates at 47 % of the cPAD. Risks were lower for all other population subgroups, in cluding the general U . S . population which has a % c PAD . o f 22 %. The chronic dietary exposure assessment is not likely to underestimate exposure. X. List of Attachments Attachment 1 . Fluoxastrobin Chronic Dietary Analy sis Input File - Food & Water Attachment 2 . Fluoxastrobin Chronic Dietary Analy sis Results - Food & Water Attachment 3 . Fluoxastrobin Chronic Dietary Analy sis Results - Food onlyFluoxastrobin 028869 Dietary Exposure and Risk Assessment DP Number: 380847

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Page 9 of 13 Filename: C: \ Documents and Settings \ cwalls \ My Documents \ Cassi \ HED \ Fluoxastrobin \ Fluoxastrobin_tol+water_121510.R98 Chemical: Fluoxastrobin RfD(Chronic): .015 mg/kg bw/day NOEL(Chronic): 1.5 mg/kg bw/day RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 12
- 16 - 2010/15 :27:05/8 Program ver. 2.03 Comment: proposed squash/cucumber use, new EDWC

------------------------------------------------ ------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

-------- ---- ------------------------------- -- -------- ------ ------ ----- 01030150 1CD Arrowroot, flour 0.010000 1.000 1.000 01030151 1CD Arrowroot, flour - babyfoo d 0.010000 1.000 1.000 01030170 1CD Artichoke, Jerusalem 0.010000 1.000 1.000 01030820 1CD Cassava 0.010000 1.000 1.000 01030821 1CD Cassava - babyfood 0.010000 1.000 1.000 01031390 1CD Dasheen, corm 0.010000 1.000 1.000 01031660 1CD Ginger 0.010000 1.000 1.000 01031661 1CD Ginger - babyfood 0.010000 1.000 1.000 01031670 1CD Ginger, d ried 0.010000 1.000 1.000 01032960 1C Potato, chips 0.010000 1.000 1.000 01032970 1C Potato, dry (granules/ flakes) 0.010000 1.000 1.000 01032971 1C Potato, dry (granules/ flakes)
- b 0.010 000 1.000 1.000 01032980 1C Potato, flour 0.010000 1.000 1.000 01032981 1C Potato, flour - babyfood 0.010000 1.000 1.000 01032990 1C Potato, tuber, w/peel 0.010000 1.000 1.000 01032991 1 C Potato, tuber, w/peel
- babyfood 0.010000 1.000 1.000 01033000 1C Potato, tuber, w/o peel 0.010000 1.000 1.000 01033001 1C Potato, tuber, w/o peel
- babyfood 0.010000 1.000 1.000 01033660 1CD Sweet potato 0.010000 1.000 1.000 01033661 1CD Sweet potato - babyfood 0.010000 1.000 1.000 01033710 1CD Tanier, corm 0.010000 1.000 1.000 01033870 1CD Turmeric 0.010000 1.000 1.000 01034060 1CD Yam, true 0.010000 1.000 1.000 01034070 1CD Yam bean 0.010000 1.000 1.000 04020760 4B Cardoon 4.000000 1.000 1.000 04020850 4B Celery 4.000000 1.000 1.000 04020851 4B Celery - babyfood 4.000000 1.000 1.000 04020860 4B Celery, juice 4.000000 1.000 1.000 04020870 4B Celtuce 4.000000 1.000 1.000 04021520 4B Fennel, Florence 4.000000 1.000 1.000 04023220 4B Rhubarb 4.000000 1.000 1.000 04023670 4B Swiss chard 4.000000 1.000 1.000 06003470 6 Soybean, seed 0.050000 1.000 1.000 06003480 6 Soybean, flour 0.050000 1.000 1.000 06003481 6 Soybean, flour - babyfood 0.050000 1.000 1.000 06003490 6 Soybean, soy milk 0.050000 1.000 1.000 06003491 6 Soybean, soy milk - babyfood or in 0.050000 1.000 1.000 06003500 6 Soybean, oil 0.050000 1.000 1.000 06003501 6 Soybean, oil - babyfood 0.050000 1. 000 1.000 08001480 8 Eggplant 1.000000 1.000 1.000 08002340 8 Okra 1.000000 1.000 1.000 08002700 8 Pepper, bell 1.000000 1.000 1.000 08002701 8 Pepp er, bell - babyfood 1.000000 1.000 1.000 08002710 8 Pepper, bell, dried 1.000000 1.000 1.000 08002711 8 Pepper, bell, dried - babyfood 1.000000 1.000 1.000 08002720 8 Pepper, nonbell 1.000000 1.000 1.000 08002721 8 Pepper, nonbell - babyfood 1.000000 1.000 1.000 08002730 8 Pepper, nonbell, dried 1.000000 1.000 1.000 08003740 8 Tomatillo 1.000000 1.000 1.000 08003 750 8 Tomato 1.000000 1.000 1.000 08003751 8 Tomato - babyfood 1.000000 1.000 1.000Fluoxastrobin 028869 Dietary Exposure and Risk Assessment DP Number: 380847

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Page 10 of 13 08003760 8 Tomato, paste 1.500000 1.000 1.000 08003761 8 Tomato, paste - babyfood 1.500000 1.000 1.000 08003770 8 Tomato, puree 1.000000 1.000 1.000 08003771 8 Tomato, puree - babyfood 1.000000 1.000 1.000 08003780 8 Tomato, dried 1.000000 14.300 1.000 08003781 8 Tomato, dried - babyfood 1.000000 14.300 1.000 08003790 8 Tomato, juice 1.000000 1.500 1.000 09020210 9B Balsam pear 0.500000 1.000 1.000 09020880 9B Chayote, fruit 0.500000 1.000 1.000 09021020 9B Chinese waxgourd 0.500000 1.000 1.000 09021350 9B Cucumber 0.500000 1.000 1.000 09023080 9B Pumpkin 0.500000 1.000 1.000 09023090 9B Pumpkin, seed 0.500000 1.000 1.000 09023560 9B Squash, summer 0.500000 1.000 1.000 09023561 9B Squash, summer - ba byfood 0.500000 1.000 1.000 09023570 9B Squash, winter 0.500000 1.000 1.000 09023571 9B Squash, winter - babyfood 0.500000 1.000 1.000 13020570 13B Blueberry 1.900000 1. 000 1.000 13020571 13B Blueberry - babyfood 1.900000 1.000 1.000 15001200 15 Corn, field, flour 0.020000 1.000 1.000 15001201 15 Corn, field, flour - babyfood 0.020000 1.000 1.000 15001210 15 Corn , field, meal 0.020000 1.000 1.000 15001211 15 Corn, field, meal - babyfood 0.020000 1.000 1.000 15001220 15 Corn, field, bran 0.020000 1.000 1.000 15001230 15 Corn, field, starch 0.020000 1.000 1.000 15001231 15 Corn, field, starch - babyfood 0.020000 1.000 1.000 15001240 15 Corn, field, syrup 0.020000 1.500 1.000 15001241 15 Corn, field, syrup - babyfood 0.020000 1.500 1.000 15001 250 15 Corn, field, oil 0.020000 1.000 1.000 15001251 15 Corn, field, oil - babyfood 0.020000 1.000 1.000 15001270 15 Corn, sweet 0.010000 1.000 1.000 DP#364 Full comment: DP#364 445 15001271 15 Corn, sweet - babyfood 0.010000 1.000 1.000 15004010 15 Wheat, grain 0.090000 1.000 1.000 DP#364 Full comment: DP#364445 15004011 15 Wheat, grain - babyfood 0.090000 1. 000 1.000 DP#364 Full comment: DP#364445 15004020 15 Wheat, flour 0.090000 1.000 1.000 DP#364 Full comment: DP#364445 15004021 15 Wheat, flour - babyfood 0.090000 1.000 1.000 DP#364 Full comment: DP#364445 15004030 15 Wheat, germ 0.090000 1.000 1.000 DP#364 Full comment: DP#364445 15004040 15 Wheat, bran 0.150000 1.000 1.000 DP#364 Full comment: DP #364445 21000440 M Beef, meat 0.050000 1.000 1.000 21000441 M Beef, meat - babyfood 0.050000 1.000 1.000 21000450 M Beef, meat, dried 0.050000 1.920 1.000 21000460 M Beef, mea t byproducts 0.200000 1.000 1.000 DP#364 Full comment: DP#364445 21000461 M Beef, meat byproducts - babyfood 0.200000 1.000 1.000 21000470 M Beef, fat 0.100000 1.000 1.000 21000471 M Beef,fat - babyfood 0.100000 1.000 1.000 21000480 M Beef, kidney 0.200000 1.000 1.000 DP#364Fluoxastrobin 028869 Dietary Exposure and Risk Assessment DP Number: 380847

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Page 11 of 13 Full comment: DP#364445 21000490 M Beef, liver 0.200000 1.000 1.000 DP#364 Full comment: DP#364445 21000491 M Beef, liver - babyfood 0.200000 1.000 1.000 23001690 M Goat, meat 0.050000 1.000 1.000 23001700 M Goat, meat byproducts 0.200000 1.000 1.00 0 DP#364 Full comment: DP#364445 23001710 M Goat, fat 0.100000 1.000 1.000 23001720 M Goat, kidney 0.200000 1.000 1.000 DP#364 Full comment: DP#364445 23001730 M Goat, li ver 0.200000 1.000 1.000 DP#364 Full comment: DP#364445 24001890 M Horse, meat 0.050000 1.000 1.000 26003390 M Sheep, meat 0.050000 1.000 1.000 26003391 M Sheep, meat - babyfood 0.050000 1.000 1.000 26003400 M Sheep, meat byproducts 0.200000 1.000 1.000 DP#364 Full comment: DP#364445 26003410 M Sheep, fat 0.100000 1.000 1.000 2600 3411 M Sheep, fat - babyfood 0.100000 1.000 1.000 26003420 M Sheep, kidney 0.200000 1.000 1.000 DP#364 Full comment: DP#364445 26003430 M Sheep, liver 0.200000 1.000 1.0 00 DP#364 Full comment: DP#364445 27002220 D Milk, fat 0.500000 1.000 1.000 27002221 D Milk, fat - baby food/infant for 0.500000 1.000 1.000 27012230 D Milk, nonfat solids 0.020000 1 .000 1.000 27012231 D Milk, nonfat solids - baby food/in 0.020000 1.000 1.000 27022240 D Milk, water 0.020000 1.000 1.000 27022241 D Milk, water - babyfood/infant form 0.020000 1.000 1.000 27032251 D Mil k, sugar (lactose) - baby food/ 0.020000 1.000 1.000 86010000 O Water, direct, all sources 0.052900 1.000 1.000 86020000 O Water, indirect, all sources 0.052900 1.000 1.000 95001300 O Cranberry 1.900000 1.000 1.000 95001301 O Cranberry - babyfood 1.900000 1.000 1.000 95001310 O Cranberry, dried 1.900000 1.000 1.000 95001320 O Cranberry, juice 1.900000 1.100 1.000 9500 1321 O Cranberry, juice - babyfood 1.900000 1.100 1.000 95002630 O Peanut 0.020000 1.000 1.000 DP#364 Full comment: DP#364445 95002640 O Peanut, butter 0.020000 1.890 1.0 00 DP#364 Full comment: DP#364445 95002650 O Peanut, oil 0.060000 1.000 1.000 DP#364 Full comment: DP#364445 95003590 O Strawberry 1.900000 1.000 1.000 95003591 O Strawberry - babyfood 1.900000 1.000 1.000 95003600 O Strawberry, juice 1.900000 1.000 1.000 95003601 O Strawberry, juice - babyfood 1.900000 1.000 1.000Fluoxastrobin 028869 Dietary Exposure and Risk Assessment DP Number: 380847

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Page 12 of 13 U.S. Environmental Protection Agency Ver. 2.00 DEEM - FCID Chronic analysis for FLUOXASTROBIN (1994 - 98 data) Residue file name: C: \ Documents and Settings \ cwalls \ My Documents \ Cassi \ HED \ Fluoxastrobin \ Fluoxastrobin_tol+water_121510.R98 Adjustment factor #2 NOT used. Analysis Date 12 - 16 - 2010/15:30:21 Residue file dated: 12
- 16 - 2010/15:27:05/8 Reference dose (RfD, Chronic) = .015 mg/kg bw/day COMMENT 1: proposed squash/cucumber use, new EDWC

========= ====================================================================== Total exposure by population subgroup

------------------------------------------------------------------------------- Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

---- ---------------------------------- ------------- --------------- U.S. Population (total) 0.003269 21.8% U.S. Population (spring season) 0.003304 22.0% U.S. Population (summer season) 0.003440 22.9% U.S. Population (autumn season) 0.003180 21.2% U.S. Population (winter season) 0.003151 21.0% Northeast region 0.003289 21.9% Midwest region 0.003335 22.2% Southern region 0.002977 19.8% Western region 0.003646 24.3% Hispanics 0.003765 25.1% Non - hispanic whites 0.003245 21.6% Non - hispanic blacks 0.002856 19.0% Non - hisp/non
- white/non
- black 0.003669 24.5% All infants (< 1 year) 0.005125 34.2% Nursing infants 0.002053 13.7% Non - nursing infants 0.006291 41.9% Children 1 - 6 yrs 0.006259 41.7% Children 7 - 12 yrs 0.003916 26.1% Females 13 - 19 (not preg or nursing) 0.002568 17.1% Females 20+ (not preg or nursing) 0.002839 18.9% Females 13 - 50 yrs 0.002933 19.6% Females 13+ (preg/not nursing) 0.003156 21.0% Females 13+ (nursing) 0.003543 23.6% Males 13 - 19 yrs 0.002860 19.1% Males 20+ yrs 0.002804 18.7% Seniors 55+ 0.002859 19.1% Children 1 - 2 yrs 0.006979 46.5% Children 3 - 5 yrs 0.006103 40.7% Children 6 - 12 yrs 0.004125 27.5% Youth 13 - 19 yrs 0.002720 18.1% Adul ts 20 - 49 yrs 0.002821 18.8% Adults 50+ yrs 0.002844 19.0% Females 13 - 49 yrs 0.002765 18.4%

------------------------------------- ------------------------------------------Fluoxastrobin 028869 Dietary Exposure and Risk Assessment DP Number: 380847

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Page 13 of 13 U.S. Environmental Protection Agency Ver. 2.00 DEEM - FCID Chronic analysis for FLUOXASTROBIN (1994 - 98 data) Residue file name: C: \ Documents and Settings \ cwalls \ M y Documents \ Cassi \ HED \ Fluoxastrobin \ Fluoxastrobin_tol_121510.R98 Adjustment factor #2 NOT used. Analysis Date 12 - 28 - 2010/13:40:05 Residue file dated: 12
- 28 - 2010/13:39:07/8 Reference dose (RfD, Chronic) = .015 mg/kg bw/day COMMENT 1: proposed squash/cucumber use; no water

=============================================================================== Total exposure by population subgroup

------------------------------------------------- ------------------------------ Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- --------------- U.S. Population (total) 0.002154 14.4% U.S. Population (spring sea son) 0.002199 14.7% U.S. Population (summer season) 0.002242 14.9% U.S. Population (autumn season) 0.002102 14.0% U.S. Population (winter season) 0.002073 13.8% Northeast region 0.002272 15.1% Midwest region 0.002208 14.7% Southern region 0.001917 12.8% Western region 0.002368 15.8% Hispanics 0.002500 16.7% Non - hispanic whites 0.002157 14.4% Non - hispanic blacks 0.001797 12.0% Non - hisp/non
- white/non
- black 0.002302 15.3% All infants (< 1 year) 0.001470 9.8% Nursing infants 0.000697 4.6% Non - nursing infants 0.001763 11.8% Children 1 - 6 yrs 0.004701 31.3% Children 7 - 12 yrs 0.002903 19.4% Females 13 - 19 (not preg or nursing) 0 .001784 11.9% Females 20+ (not preg or nursing) 0.001726 11.5% Females 13 - 50 yrs 0.001854 12.4% Females 13+ (preg/not nursing) 0.002072 13.8% Females 13+ (nursing) 0.001999 13.3% Males 13 - 19 yrs 0.002040 13.6% Males 20+ yrs 0.001804 12.0% Seniors 55+ 0.001764 11.8% Children 1 - 2 yrs 0.005323 35.5% Children 3 - 5 yrs 0.004553 30.4% Children 6 - 12 yrs 0.003055 20.4% Youth 13 - 19 yrs 0.001914 12.8% Adults 20 - 49 yrs 0.001780 11.9% Adults 50+ yrs 0.001749 11.7% Females 13 - 49 yrs 0.001728 11.5%

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