# Patent

## Title
Methods for generating new hair follicles, treating baldness, and hair removal

## Abstract

The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

## Background
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a continuation of U.S. patent application Ser. No. 11/887,104, filed Sep. 25, 2007, now abandoned which is a National Phase Application of PCT International Application No. PCT/US06/11319, International Filing Date Mar. 28, 2006, claiming priority of Provisional Patent Applications, 60/665,857, filed 29 Mar. 2005, and 60/683,293, filed 23 May 2005 all which are incorporated herein by reference in their entirety.


FIELD OF INVENTION
The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.
BACKGROUND OF THE INVENTION
Follicular neogenesis is defined as the generation of new hair follicles (HF) after birth. Humans are born with a full complement of HF, which can change in size and growth characteristics as in early baldness or can ultimately degenerate and disappear as in late stages of baldness or in permanent scarring (cicatricial) alopecias. Therefore, the generation of new HF is desirable in the treatment of common baldness as well as less common hair loss conditions, such as discoid lupus erythematosis, congenital hypotrichosis, lichen planopilaris and other scarring alopecias.
SUMMARY OF THE INVENTION
The present invention provides methods of treating baldness in a subject and generating new hair follicles (HF), comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.
In one embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject.
In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject.
In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle (HF) cell, thereby treating baldness in a scalp, eyebrow, or scarred region.
In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a method for removal of an HF from a skin or scalp of a subject, comprising the steps of: (a) disrupting an epidermis of the skin or scalp; and (b) contacting the skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, thereby removing an HF from a skin or scalp of a subject.
In another embodiment, the present invention provides a method for increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject.
In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of said scalp, eyebrow, or scarred region; and (b) contacting said scalp, eyebrow, or scarred region with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a method for treating an AGA in a scalp, comprising the steps of: (a) disrupting an epidermis of said scalp; and (b) contacting said scalp with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby treating an AGA in a scalp. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.



BRIEF DESCRIPTION OF THE FIGURES
FIG. 1: Epidermal abrasion results in de novo hair follicle (HF) formation. HF at progressive stages of development are depicted in the left, center, and right panels. The arrow in the left panel indicates a hair germ. The dark stained cells are progeny of HF stem cells in the bulge.
FIG. 2: BrdU labeling of HF following epidermal abrasion. HF at progressive stages of development are depicted in the left, center, and right panels.
FIG. 3. The wound site did not contain HF immediately after re-epithelialization. Top view (left panel) and tissue section (right panel) of the site 10 days after wound induction.
FIG. 4. Appearance of hair germs 12 days after wound induction. Arrow indicates hair germ.
FIG. 5. Epidermal Disruption-Induced HF neogenesis (EDIHN)-induced hair germs express K17. Two different hair germs are depicted in the left and right panels.
FIG. 6. EDIHN-induced hair germs contain dermal papilla (DP) cells, as evidenced by alkaline phosphatase (AP) staining. Arrows indicate DP cells. Left panel: hair germs. Right panel: HF at a further developmental stage.
FIG. 7. Histological comparison between EDIHN-induced and embryonic HF. Top left, second from left, third from left, and right panels: Progressive stages of EDIHN-induced HF development. Bottom left, center, and right panels: Progressive stages of and embryonic HF development.
FIG. 8. Induction of several markers of embryonic HF development, Lef1 (left panel), wingless/int (Wnt) 10b (center panel), and sonic hedgehog (Shh; right panel), by EDIHN. HF structures are indicated by arrowheads.
FIG. 9. Proliferative activity during EDIHN, as evidenced by BrdU pulse-labeling. Progressive stages of HF development are depicted in the left, center, and right panels.
FIG. 10. Induction of HF markers S100A3 (left panel; tissue section parallel to HF axis) and S100A6 (right panel; cross-sectional view of follicle) by EDIHN.
FIG. 11. New hair growth 25 days (left panel) and 45 days (right panel) after wound induction.
FIG. 12. Schematic of whole-mount EDIHN assay.
FIG. 13. Repopulation of stem cells in the bulge of EDIHN-induced HF, as evidenced by retention of BrdU label following a chase period. Left panel: lower magnification: 50×. Right panel: higher magnification: 400×.
FIG. 14. A. Stem cells in EDIHN-induced HF express K15. Left top panel: Top view of wound site. Bottom, far left panel: epidermis whole mount; bottom, second from left panel: same as [bottom, far left] panel but viewed under white light; right panel: tissue sections. B. Neogenesis HF proceed to next hair cycle.
FIG. 15. Schematic of creation of new HF by EDIHN.
FIG. 16. No new HF are evident 11 days after wound induction in 21-day-old mice. Top panel: macroscopic examination; bottom left panel: AP staining of the dermis; bottom right panel: K17 staining of the epidermis.
FIG. 17. 14 days after wound induction, new HF have begun to form as evidenced by AP staining of the dermis (left panel) and K17 staining of the epidermis (right panel). Main panels: 10× magnification. Inserts: 80× magnification.
FIG. 18. 17 days after wound induction, new HF are more developed. Left panel: AP staining of the dermis; right panel: K17 staining of the epidermis. Main panels: 10× magnification. Inserts: 80× magnification.
FIG. 19. Wounds closed similar in mice subjected to depilation, then wounding (left 3 mice in each panel) vs. wounding alone (right 4 mice in each panel). Left panel: immediately following wounding. Right panel: 10 days following wounding.
FIG. 20. Anagen induction by depilation prior to wounding enhances the efficiency of EDIHN. A. Top panel: lower left panel AP staining of the dermis; lower right panel: K17 staining of the epidermis. B. Graphical representation of enhancement of EDIHN by depilation.
FIG. 21. A. EDIHN in human skin grafted to immunodeficient (scid) mice, seven days after induction of an excisional wound. Arrows indicate new HF. B. Dermal abrasion of human skin grafts results in EDIHN. Human adult skin (W) was grafted onto mice, abraded, and examined seven days later, by staining for S100A6 (first, second, and fourth rows) or S100A4 (third row). Hair germs (HG) and dermal papilla (DP) are indicated. Human fetal skin (F) with normal developing hair follicles is shown for comparison. Mouse skin 17d post wounding was included as a control (top left panel).
FIG. 22. Transcripts up-regulated at least 2-fold in activated HF cells, as assessed by dChip analysis. (A). Mean values and standard errors of the up-regulated transcripts in non-activated (“bs-line”) and activated (“expt”) samples and fold-changes and differences between non-activated and activated values are depicted. (B). Raw data for up-regulated transcripts in non-activated and activated cells. “Ctrl” denotes non-activated and “High-dep” denotes activated cells. (C). Additional information about up-regulated transcripts.
FIG. 23. Pigmented hair follicle neogenesis observed in the skin of Dkk1-expressing mice following EDIHN A. 3.2× magnification. B. 8× magnification.
FIG. 24. Control mice lacked pigmented HF.
FIG. 25. EGF inhibits HF formation by EDIHN. A. K17 staining of wounded skin of representative mouse treated with EGF. Magnification is 4×. B. High magnification view (10×) of skin depicted in (A). C. K17 staining of wounded skin of representative control mouse that received no EGF after wounding. Magnification is 4×. D. Higher magnification view (10×) of skin depicted in (D).
FIG. 26. Administration of an EGF receptor inhibitor (AG1478) leads to generation of more and larger HF compared with controls. A. Top: skin of 2 control mice. Outer dashed line indicates the extent of the wounded area after contraction and healing; inner dashed line indicates the area of neogenesis. Bottom: skin of 2 treated mice, in which the wounded area and area of neogenesis largely coincide, with the exception of a small area on the left side of the encircled area in each panel. B. Large hair follicles developed in the wounded area in the AG1478-injected mice. Left panel: epidermis stained for K17, with three large hair follicles next to each other. Right panel: dermis stained for AP with large coalescing DP areas. Scale Bars: 200 μm.
FIG. 27. A. Increased hair follicle formation in K14-Wnt7a mice. Left panel: Wnt7a transgenic mice. Right panel: control (wild-type) mice. B. Quantiation of experiment with 4 week old mice. C. Quantiation of experiment with 3 week old mice



DETAILED DESCRIPTION OF THE INVENTION
The present invention provides methods of treating baldness in a subject and generating new HF, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.
In one embodiment, the present invention provides a method for generating a hair follicle (HF) in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject.
In another embodiment, the present invention provides a method for generating an HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject.
In another embodiment, the present invention provides a method for generating a new HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby generating a new HF in a scalp, eyebrow, or scarred region of a subject.
In another embodiment, the present invention provides a method for increasing the number of HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby increasing the number of HF in a scalp, eyebrow, or scarred region of a subject.
In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the compound or factor.
In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the compound or factor.
In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the compound or factor.
In another embodiment, the present invention provides a method for increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject. In another embodiment, the factor is an inhibitor of an EGF protein or an EGFR. In another embodiment, the factor is a Hedgehog protein, a nucleotide encoding same or an activator of same. In another embodiment, the factor is an androgen antagonist. In another embodiment, the factor is any other compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of said scalp, eyebrow, or scarred region; and (b) contacting said scalp, eyebrow, or scarred region with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.
The precursor cell of methods and compositions of the present invention, is, in another embodiment, a HF stem cell. In another embodiment, the precursor cell is an epidermal cell. In another embodiment, the precursor cell is a dermal papilla cell. In another embodiment, the precursor cell is a connective tissue sheath cell. In another embodiment, the precursor cell is any other type of cell known in the art that is capable of differentiation into a hair follicle cell. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of said scalp, eyebrow, or scarred region; and (b) contacting said scalp, eyebrow, or scarred region with a precursor cell that is capable of differentiation into a hair follicle cell, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject.
In another embodiment, the present invention provides a method for treating an AGA in a scalp, comprising the steps of: (a) disrupting an epidermis of said scalp; and (b) contacting said scalp with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby treating an AGA in a scalp. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a method for treating an AGA in a scalp, comprising the steps of: (a) disrupting an epidermis of said scalp; and (b) contacting said scalp with a precursor cell that is capable of differentiation into a hair follicle cell, thereby treating an AGA in a scalp.
In another embodiment, the inductive cell is a mesenchymal cell. In another embodiment, the inductive cell is any other type of inductive cell enumerated herein. In another embodiment, the inductive cell is any other type of inductive cell known in the art. Each possibility represents a separate embodiment of the present invention.
“Contacting” as used herein refers, in another embodiment, to bringing the scalp, eyebrow, etc, into to contact with the compound, factor, cell, etc. In another embodiment, the term refers to embedding the compound, factor, cell, etc into the scalp, eyebrow, etc. In another embodiment, the term refers to injecting the compound, factor, cell, etc into the scalp, eyebrow, etc. In another embodiment, term refers to any other type of contacting known in the art. Each possibility represents a separate embodiment of the present invention.
“Promotes a differentiation” refers, in another embodiment, to the act of increasing the percentage of cells that will differentiate as indicated. In another embodiment, the term refers to increasing the number of cells per unit area of skin that will differentiate. In another embodiment, the promoter of differentiation is active in the milieu of the skin. Each possibility represents a separate embodiment of the present invention.
“Uncommitted epidermal cell” refers, in another embodiment, to an epidermal stem cell. In another embodiment, the epidermal cell is a bulge cell. In another embodiment, the epidermal cell is a bulge-derived cell. In another embodiment, the epidermal cell is any other type of cell known in the art that can be induced to differentiate into an HF cell.
The “HF cell” that results from the differentiation is, in another embodiment, an HF stem cell. In another embodiment, the HF cell is a dermal papilla cell. In another embodiment, the HF cell is a bulb cell. In another embodiment, the HF cell is a matrix cell. In another embodiment, the HF cell is a hair shaft cell. In another embodiment, the HF cell is an inner root sheath cell. In another embodiment, the HF cell is an outer root sheath cell. In another embodiment, the HF cell is a melanocyte stem cell. In another embodiment, the HF cell is a melanocyte. Each type of uncommitted epidermal cell and HF cell represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle (HF) cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is administered in a solution. In another embodiment, the compound or factor is administered in a cream. In another embodiment, the compound or factor is administered in an ointment. In another embodiment, the compound or factor is administered in a slow release formulation. In another embodiment, the compound or factor is administered in a liposome encapsulated formulation. In another embodiment, the compound or factor is directly injected. In another embodiment, the compound or factor is administered by any other method known in the art. Each possibility represents a separate embodiment of the present invention.
The compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is, in another embodiment, an inhibitor of an Epidermal Growth Factor (EGF). In another embodiment, the compound or factor is an inhibitor of an EGF receptor. Each possibility represents a separate embodiment of the present invention.
As provided herein (Example 11), activating one or more pathways in which EGF is involved (by injection of EGF) blocks the formation of HF. Thus, antagonizing the pathway increases HF formation, as demonstrated in Example 12.
In another embodiment, the inhibitor of an EGF or an EGF receptor is panitumumab. In another embodiment, the inhibitor is AG1478. In another embodiment, the inhibitor is nimotuzumab. In another embodiment, the inhibitor is an antibody that binds EGF or EGFR. In another embodiment, the inhibitor is HuMax-EGFR® (Genmab, Copenhagen, Denmark). In another embodiment, the inhibitor is cetuximab. In another embodiment, the inhibitor is IMC 11F8. In another embodiment, the inhibitor is matuzumab. In another embodiment, the inhibitor is SC 100. In another embodiment, the inhibitor is ALT 110. In another embodiment, the inhibitor is PX 1032. In another embodiment, the inhibitor is BMS 599626. In another embodiment, the inhibitor is MDX 214. In another embodiment, the inhibitor is PX 1041. In another embodiment, the inhibitor is any other inhibitor of an EGF or an EGF receptor known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is an inhibitor of a tyrosine kinase activity of an EGF receptor. In another embodiment, the inhibitor is gefitinib. In another embodiment, the inhibitor is erlotinib. In another embodiment, the inhibitor is canertinib. In another embodiment, the inhibitor is leflunomide. In another embodiment, the inhibitor is A77 1726. In another embodiment, the inhibitor is pelitinib. In another embodiment, the inhibitor is ZD 1839. In another embodiment, the inhibitor is CL 387785. In another embodiment, the inhibitor is EKI 785. In another embodiment, the inhibitor is vandetanib. In another embodiment, the inhibitor is any other inhibitor of a tyrosine kinase activity of an EGF receptor known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the EGF or EGFR antagonist is a carboxypeptidase inhibitor from potato (PCI) protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is a sprouty protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is an Argos protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is a lefty protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is an antibody that recognizes EGF or EGFR, or a fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is small molecule inhibitor that binds and reduces the activity of EGF or EGFR. In another embodiment, the EGF or EGFR antagonist is CRM197. In another embodiment, the EGF or EGFR antagonist is IMC-C225 (ImClone Systems, New York, N.Y.). In another embodiment, the EGF or EGFR antagonist is any other antagonist of EGF or EGFR known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the inhibitor of an EGF protein or an EGF receptor.
In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the inhibitor of an EGF protein or an EGF receptor.
In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the inhibitor of an EGF protein or an EGF receptor.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a β-catenin protein. In another embodiment, the compound or factor is a nucleotide that encodes a β-catenin protein. In another embodiment, the compound or factor is an activator of a β-catenin protein. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the β-catenin protein. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a use of (a) a β-catenin protein; (b) a nucleotide encoding a β-catenin protein; or (c) a compound or factor that activates a β-catenin protein, for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the β-catenin protein, nucleotide, compound or factor.
In another embodiment, the present invention provides a use of (a) a β-catenin protein; (b) a nucleotide encoding a β-catenin protein; or (c) a compound or factor that activates a β-catenin protein, for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the β-catenin protein, nucleotide, compound or factor.
In another embodiment, the present invention provides a use of (a) a β-catenin protein; (b) a nucleotide encoding a β-catenin protein; or (c) a compound or factor that activates a β-catenin protein, for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the β-catenin protein, nucleotide, compound or factor.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a fibroblast growth factor (FGF) protein. In another embodiment, the compound or factor is a nucleotide that encodes an FGF protein. In another embodiment, the compound or factor is an FGF receptor. In another embodiment, the compound or factor is a nucleotide that encodes an FGF receptor. In another embodiment, the compound or factor is an activator of an FGF protein. In another embodiment, the compound or factor is an activator of FGF receptor. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the FGF protein or FGF receptor. In another embodiment, the protein that is inhibited is an FGF binding protein. In another embodiment, the protein that is inhibited is FGF-bp1. Each possibility represents a separate embodiment of the present invention.
Is provided herein, FGF and its receptor are upregulated, under the conditions utilized herein, upon HF stem cell differentiation (Example 9). Moreover, FGF-bp1 is downregulated, under the conditions utilized herein, upon HF stem cell differentiation. Thus, FGF and its receptor promote differentiation of uncommitted epidermal cells into HF cells.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is an ectodysplasin protein (referred to, in another embodiment, as “eda”; in another embodiment, as “ectodermodysplasin protein.”) In another embodiment, the ectodysplasin protein is Eda-A1. In another embodiment, the compound or factor is an ectodysplasin receptor (referred to, in another embodiment, as “edar”). In another embodiment, the compound or factor is an activator of an ectodysplasin protein. In another embodiment, the compound or factor is an activator of an ectodysplasin receptor. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the ectodysplasin protein or ectodysplasin receptor. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the eda protein of methods and compositions of the present invention has the sequence:
MGYPEVERRELLPAAAPRERGSQGCGCGGAPARAGEGNSCLLFLGFFGLSLALHLLTLCC YLELRSELRRERGAESRLGGSGTPGTSGTLSSLGGLDPDSPITSHLGQPSPKQQPLEPGEAAL HSDSQDGHQMALLNFFFPDEKPYSEEESRRVRRNKRSKSNEGADGPVKNKKKGKKAGPP GPNGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGPQGPPGLQGPSGAADKAGTR ENQPAVVHLQGQGSAIQVKNDLSGGVLNDWSRITMNPKVFKLHPRSGELEVLVDGTYFIY SQVEVYYINFTDFASYEVVVDEKPFLQCTRSIETGKTNYNTCYTAGVCLLKARQKIAVKM VHADISINMSKHTTFFGAIRLGEAPAS (GenBank Accession No: NM_001399; SEQ ID No: 274). In another embodiment, the eda protein has a sequence selected from the sequences set forth in GenBank entries NM_001005609, NM_001005610, NM_001005611, NM_001005612, NM_001005613, NM_001005614, NM_001005615, AF040628, AF061194, AF061193, AF061192, AF061191, AF061190, AF061189, and AF060999. In another embodiment, the eda protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an Eda protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the edar protein of methods and compositions of the present invention has the sequence:
MAHVGDCTQTPWLPVLVVSLMCSARAEYSNCGENEYYNQTTGLCQECPPCGPGEEPYLS CGYGTKDEDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVLTPGDMENDAECGPCLP GYYMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGASANFPGTSGSSTLSPFQHAHKELS GQGHLATALIIAMSTWIMAIAIVLIIMFYILKTKPSAPACCTSHPGKSVEAQVSKDEEKKEAP DNVVMFSEKDEFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEPAPDKQGSPELCLLS LVHLAREKSATSNKSAGIQSRRKKILDVYANVCGVVEGLSPTELPFDCLEKTSRMLSSTYN SEKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDRISTAGYSIPELLTKLVQIERLDAVES LCADILEWAGVVPPASQPHAAS (GenBank Accession No: BC093872; SEQ ID No: 275). In another embodiment, the edar protein has a sequence selected from the sequences set forth in GenBank entries BC093870; BC034919; NM_021783; NM−022336; AY152724; AF298812; AH008077; AF130996; AF130988. In another embodiment, the edar protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In, another embodiment, a biologically active fragment of an Edar protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Noggin protein. In another embodiment, the compound or factor is a nucleotide encoding a Noggin protein. In another embodiment, the compound or factor is an activator of a Noggin protein. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the Noggin protein. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the Noggin protein of methods and compositions of the present invention has the sequence:
MERCPSLGVTLYALVVVLGLRATPAGGQHYLHIRPAPSDNLPLVDLEEHPDPIFDPKEKDLNE TLLRSLLGGHYDPGFMATSPPEDRPGGGGGAAGGAEDLAELDQLLRQRPSGAMPSEIKGLE FSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRS CSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWIPIQYPIISECKCSC (GenBank Accession No: NM_005450; SEQ ID No: 276). In another embodiment, the Noggin protein has a sequence selected from the sequences set forth in GenBank entries BC034027 and U31202. In another embodiment, the Noggin protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a Noggin protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Hedgehog protein. In another embodiment, the compound or factor is a nucleotide encoding a Hedgehog protein. In another embodiment, the compound or factor is an activator of a Hedgehog protein. In another embodiment, the compound or factor is a sonic Hedgehog protein. In another embodiment, the compound or factor is a nucleotide encoding a sonic Hedgehog protein. In another embodiment, the compound or factor is an activator of a sonic Hedgehog protein. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the Hedgehog protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. NM_000193. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries L38518 and NP_000184. In another embodiment, the Hedgehog protein has any other Hedgehog sequence known in the art. In another embodiment, the Hedgehog protein has any other sonic Hedgehog sequence known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Transforming Growth Factor (TGF)-beta1 protein. In another embodiment, the compound or factor is a nucleotide encoding a TGF-beta1 protein. In another embodiment, the compound or factor is an activator of a TGF-beta1 protein. In another embodiment, the compound or factor is a TGF-beta3 protein. In another embodiment, the compound or factor is a nucleotide encoding a TGF-beta3 protein. In another embodiment, the compound or factor is an activator of a TGF-beta3 protein. In another embodiment, the compound or factor is an antagonist of a TGF-beta1 protein. In another embodiment, the compound or factor is an antagonist of a TGF-beta3 protein. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the TGF-beta1 protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. BC000125. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries BC001180, BC022242, and NM_000660. In another embodiment, the TGF-beta1 protein has any other TGF-beta1 sequence known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the TGF-beta3 protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. J03241. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries NM_003239, BC018503, BT007287 and X14149. In another embodiment, the TGF-beta3 protein has any other TGF-beta3 sequence known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell acts directly on the uncommitted epidermal cell. In another embodiment, the compound or factor acts on the uncommitted epidermal cell via a mesenchymal cell. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the mesenchymal cell is a dermal condensate cell. In another embodiment, the mesenchymal cell is a DP cell. In another embodiment, the mesenchymal cell is another cell type or differentiation stage in the dermal condensate-DP lineage. In another embodiment, the mesenchymal cell is any other type of mesenchymal cell known in the art. Each possibility represents a separate embodiment of the present invention.
The EGFR of methods and compositions of the present invention has, in another embodiment, the sequence:
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVL SNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQN HLGSCQKCDPSCPNGSCWGAGEENCQKLTKJICAQQCSGRCRGKSPSDCCHNQCAAGCTG PRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVV TDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKN CTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEII RGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKT KIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREF VENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWK YADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMR RRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLW IPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMP FGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKI TDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGS KPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQ RYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSS LSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKR PAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQ KGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA (GenBank Accession No: NM_005228; SEQ ID No: 277). In another embodiment, the EGFR has a sequence selected from the sequences set forth in GenBank entries NM_201282, NM_201283, NM_201284, BC094761, AF288738, AY588246, AY573061, X17054, AF125253, U48722, K03193, and AY698024. In another embodiment, the EGFR is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an EGFR is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.
The EGF of methods and compositions of the present invention has, in another embodiment, the sequence:
MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTN YEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINW INEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADL DGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNL FAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDT WEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTL GCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLER DGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDI RHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEE GVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFW TDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRR LTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVVVHPL AKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDL KNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQC LKGFAGDGKLCSDIDECEMGVPVCPPASSKClNTEGGYVCRCSEGYQGDGIHCLDIDECQLG VHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHD GYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVVAVC VVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRSRRPADTEDGMSSCPQPWFV VIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGMGTEQGCWIPVSSDKGSCP QVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPPHQMELTQ (GenBank Accession No: NM_001963; SEQ ID No: 278). In another embodiment, the EGF has a sequence selected from the sequences set forth in GenBank entries BC093731, AY548762, and X04571. In another embodiment, the EGF is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an EGF is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.
The beta-catenin protein of methods and compositions of the present invention has, in another embodiment, the sequence:
MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDT SQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHP TNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLS KKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPAL VKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDC LQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGG MQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAG ILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQN AVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQ DTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIE NIQRVAAGVLCELAQDKEAAEMEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQD YKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALG MDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL (GenBank Accession No: NM_001904; SEQ ID No: 279). In another embodiment, the beta-catenin protein has a sequence selected from the sequences set forth in GenBank entries BC058926, X87838, AF130085, AB062292, Z19054, and NP_001895. In another embodiment, the beta-catenin protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a beta-catenin protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.
The Wnt protein of methods and compositions of the present invention has, in another embodiment, the sequence:
MNRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIVIGE GSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACT QGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLH NNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRA SRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGC DLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK (GenBank Accession No: BC008811; SEQ ID No: 280). In another embodiment, the Wnt protein has a sequence selected from the sequences set forth in GenBank entries NM_004625, D83175, U53476, and NP_004616. In another embodiment, the Wnt protein is a Wnt7 protein. In another embodiment, the Wnt protein is a Wnt7a protein. In another embodiment, the Wnt protein is Wnt1 protein. In another embodiment, the Wnt protein is a Wnt3 protein. In another embodiment, the Wnt protein is a Wnt3a protein. In another embodiment, the Wnt protein is a Wnt10 protein. In another embodiment, the Wnt protein is a Wnt10a protein. In another embodiment, the Wnt protein is a Wnt10b protein. In another embodiment, the Wnt protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a Wnt protein is utilized in a method of the present invention. In another embodiment, a biologically active fragment of a Wnt7 protein is utilized in a method of the present invention. In another embodiment, a biologically active fragment of a Wnt7a protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a protein encoded by a ribonucleic acid (RNA) molecule having a sequence selected from the sequences set forth in SEQ ID No: 1-232. In another embodiment, the compound or factor is an RNA molecule having a sequence selected from SEQ ID No: 1-232. In another embodiment, the RNA molecule is homologous to a sequence selected from SEQ ID No: 1-232. In another embodiment, the RNA molecule is an isoform of a sequence selected from SEQ ID No: 1-232. In another embodiment, the compound or factor increases an activity of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 1-232. In another embodiment, the compound or factor increases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 1-232. Each possibility represents a separate embodiment of the present invention.
As provided herein, the transcripts depicted in Table 3 (Example 8; SEQ ID No: 1-232), the proteins they encode, and the pathways in which the proteins participate contribute significantly to HF stem cell activation. Accordingly, under the conditions utilized herein, anagen can be induced by activation of these transcripts, proteins, and pathways. Activation of the transcripts, proteins, and pathways depicted in Table 3 is thus a method for enhancing EDIHN. In another embodiment, activation of these transcripts, proteins, and pathways represents a method for enhancing hair growth in a subject.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 233-257. In another embodiment, the compound or factor is an RNA molecule having a sequence selected from SEQ ID No: 233-257. In another embodiment, the RNA molecule is homologous to a sequence selected from SEQ ID No: 233-257. In another embodiment, the RNA molecule is an isoform of a sequence selected from SEQ ID No: 233-257. In another embodiment, the compound or factor increases an activity of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 233-257. In another embodiment, the compound or factor increases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 233-257. Each possibility represents a separate embodiment of the present invention.
As provided herein, the transcripts depicted in Table 4 (Example 9; SEQ ID No: 233-257), the proteins they encode, and the pathways in which the proteins participate, contribute significantly, under the conditions utilized herein, to induction of epidermal cells to differentiate into HF stem cells. Activation of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for enhancing EDIHN. In another embodiment, activation of these transcripts, proteins, and pathways represents a method for enhancing hair growth in a subject.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a compound or factor that decreases an activity of a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 258-273. In another embodiment, the compound or factor decreases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 258-273. Each possibility represents a separate embodiment of the present invention.
As demonstrated by findings of the present invention, the transcripts depicted in Table 5 (Example 9; SEQ ID No: 258-273), the proteins they encode, and the pathways in which the proteins participate, contribute significantly, under the conditions utilized herein, to preventing induction of epidermal cells to differentiate into HF stem cells. Inhibition of the transcripts, proteins, and pathways depicted in Table 5 is thus a method for enhancing EDIHN. In another embodiment, inhibition of these transcripts, proteins, and pathways represents a method for induction of hair growth in a subject.
In one embodiment, the compound that modulates a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 233-273 or the nucleic acid encoding same is administered before the compound that modulates a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 1-232 or the nucleic acid encoding same. In another embodiment, the two compounds are administered simultaneously. Each possibility represents a separate embodiment of the present invention.
In one embodiment, a protein encoded by an RNA sequence selected from SEQ ID No: 1-273, or a compound that modulates the protein, is administered before other proteins encoded by same or compounds that modulate them, in order to further enhance their effect in generating an HF or stimulating hair growth: In another embodiment, the wnt pathway is stimulated before the hedgehog pathway. In another embodiment, the two pathways are stimulated in an overlapping fashion. In another embodiment, the two pathways are stimulated simultaneously. Each possibility represents a separate embodiment of the present invention.
In another embodiment, activating or decreasing expression of an RNA transcript in methods of the present invention occurs via a transcription mechanism (e.g. activation of expression of the RNA). In another embodiment, activating or decreasing expression of the RNA transcript occurs via a translational mechanism. In another embodiment, activating or decreasing expression of the RNA transcript occurs via a post-translational mechanism. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the nucleic acid molecule utilized in methods of the present invention is a deoxyribonucleic acid (DNA) molecule that encodes an RNA molecule having a sequence selected from the sequences set forth in the present invention.
In one embodiment, an RNA molecule of the present invention encodes a protein that plays a role in HF regeneration. In another embodiment, the RNA molecule is itself catalytically active, e.g., a ribozyme, etc. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a compound or factor that promotes placodal cell fate. As provided herein, factors that promote placodal cell fate enhance EDIHN, as exemplified in the Examples herein. In another embodiment, the compound or factor acts at the placode stage of HF development.
In another embodiment, the compound or factor inhibits a biological factor that inhibits a differentiation of an uncommitted epithelial cell into an HF cell.
In another embodiment of methods and compositions of the present invention, a composition comprising one of the above compounds or factors is administered. Each of the above types of compounds, factors, and compositions represents a separate embodiment of the present invention.
In one embodiment, the present invention provides a method for generating an HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with minoxidil, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject.
In one embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with minoxidil, thereby treating baldness in a scalp, eyebrow, or scarred region of a subject.
In another embodiment, the present invention provides a use of minoxidil for the preparation of a pharmaceutical composition for use in a method for an HF in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the minoxidil.
In another embodiment, the present invention provides a use of minoxidil for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the minoxidil.
In another embodiment, the present invention provides a method for removal of an HF from a skin or scalp of a subject, comprising the steps of (a) disrupting an epidermis of the skin or scalp; and (b) contacting the skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, thereby removing an HF from a skin or scalp of a subject.
In another embodiment, the present invention provides a method for hair removal from a skin or scalp of a subject, comprising the steps of: (a) disrupting an epidermis of the skin or scalp; and (b) contacting the skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, thereby removing hair from a skin or scalp of a subject. In another embodiment, the epidermal disruption is light dermabrasion. In another embodiment, the epidermal disruption is a non-scarring method. In another embodiment, administration of the EGF protein, EGF receptor, nucleotide, compound, or factor suppresses HF formation. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered within several days of healing. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered within about 1 day of healing. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered according to any of the timing embodiments enumerated herein for Dkk1 protein. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a use of either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, for the preparation of a pharmaceutical composition for use in a method for removal of an HF from a skin or scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the EGF protein, EGF receptor, nucleotide, compound, or factor.
In another embodiment, a composition or method of the present invention is utilized on human skin. In another embodiment, the composition or method is utilized on an area of unwanted hair growth. In another embodiment, the area is the face. In another embodiment, the area is the bikini area. In another embodiment, the area is the legs. In another embodiment, the area is the arms. In another embodiment, the area is the chest.
An “inhibitor” utilized in methods and compositions of the present invention is, in another embodiment, an antibody that binds the protein or biological factor that is the target of the inhibitor. In another embodiment, the inhibitor is a pharmacologic inhibitor. In another embodiment, the inhibitor is any other type of inhibitor known in the art. Each possibility represents a separate embodiment of the present invention.
The step of disrupting the epidermis in methods of the present invention is performed, in another embodiment, by abrading the scalp, eyebrow, or scarred region. In another embodiment, the term “abrading” refers to an act of creating an abrasion. In another embodiment, “abrading” refers to rubbing. In another embodiment, “abrading” refers to wearing away by friction. As provided herein (Example 1), epidermal abrasion causes, under the conditions utilized herein, de novo HF neo-genesis. In another embodiment, the epidermal layer is disrupted.
In one embodiment, “abrasion” has the same meaning as “abrading.” In another embodiment, “abrasion” refers to an area of the scalp or skin from which the epidermis is removed. In another embodiment, “abrasion” refers to an area of the scalp or skin from which the epidermis and dermis are removed. Each definition of “abrading”, and “abrasion” represents a separate embodiment of the present invention.
As provided herein, under the conditions utilized, epidermal disruption by a method of the present invention converts the skin back, in another embodiment, to an embryonic-like state, in which the follicle regenerates. In another embodiment, a subsequent window of opportunity is created, during which the number and size of new HF in the skin can be manipulated. In another embodiment, the administration of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell during this window causes regeneration of larger and more numerous HF. The morphology of HF in abraded skin is similar to that of embryonic HF (Example 1-2 and subsequent Examples), and the markers expressed are similar as well.
In another embodiment, the present invention provides a method of stimulating hair growth in a scalp, eyebrow, or scarred region of a subject, comprising performing a method of present invention, thereby stimulating hair growth in a scalp, eyebrow, or scarred region of a subject. As demonstrated in Example 3, EDIHN-induced HF are capable of generating hairs. Thus, methods of the present invention can be used to stimulate hair growth.
“EDIHN,” in another embodiment, refers to HF neogenesis induced by disruption of the epithelial layer. In another embodiment, the term refers to HF neogenesis induced by abrasion. In another embodiment, the term refers to HF neogenesis induced by wounding. In another embodiment, the term refers to HF neogenesis induced by disruption of the epithelial layer, followed by administration of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a method of testing an ability of a compound to modulate HF generation in vivo, comprising (a) disrupting an epithelial layer of a first scalp, eyebrow, or scarred region, whereby the first scalp, eyebrow, or scarred region has been contacted with the compound; (b) measuring a first HF generation in the first scalp, eyebrow, or scarred region; (c) disrupting an epithelial layer of a second scalp, eyebrow, or scarred region, wherein the second scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of the first subject or a second subject, whereby the second scalp, eyebrow, or scarred region has not been contacted with the compound; (d) measuring a second. HF generation in the second scalp, eyebrow, or scarred region; and (e) comparing the first HF generation to the second HF generation, whereby a difference between the first HF generation and the second HF generation indicates that the compound modulates an HF generation in vivo (Examples).
In another embodiment, the present invention provides a method of testing an ability of a compound to stimulate hair growth in vivo, comprising disrupting an epithelial layer of a first scalp, eyebrow, or scarred region, whereby the first scalp, eyebrow, or scarred region has been contacted with the compound; measuring a first HF generation in the first scalp, eyebrow, or scarred region; disrupting an epithelial layer of a second scalp, eyebrow, or scarred region, whereby the second scalp, eyebrow, or scarred region has not been contacted with the compound; measuring a second HF generation in the second scalp, eyebrow, or scarred region; and comparing the first HF generation to the second HF generation, whereby a difference between the first HF generation and the second HF generation indicates that the compound stimulates a hair growth in vivo.
In one embodiment, the methods of the present invention of testing a compound are repeated using a plurality of subjects, until a statistically significant sample has been tested.
In another embodiment of methods for testing compounds of the present invention, the first scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of a first subject. In another embodiment, the subject is a subject in need of generation of a new HF. The second scalp, eyebrow, or scarred region, in another embodiment, is a scalp, eyebrow, or scarred region of the first subject. In another embodiment, the second scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of a second subject. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the excisional wounds of methods of the present invention are created using a surgical tool. In one embodiment, the surgical tool is a dermal biopsy punch (Example 2). In another embodiment, the excisional wounds are induced by freezing or cryoinjury. The use of freezing or cryoinjury is well known in the art, and is used, for example by dermatologists to injure skin. In one embodiment, the freezing or cryoinjury results in a blister. In another embodiment, the blister is used as a “chamber” to introduce drugs and or cells into the reepithelialized area. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the excisional wounds of methods of the present invention are not surgically closed. In another embodiment, the excisional wounds are not contacted with a bandage or dressing before they heal or during a period of time after wound induction. In another embodiment, the excisional wounds are not contacted with an ointment before they heal or during a period of time after wound induction. In another embodiment, the excisional wounds are allowed to heal by secondary intention. Each possibility represents a separate embodiment of the present invention.
The subject of methods of the present invention, is, in another embodiment, a human. As provided herein (Example 7) human skin responds to EDIHN in the same manner as mouse skin. In another embodiment, the subject is a male. In another embodiment, the subject is a female. In another embodiment, the subject is any other type of subject known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the subject is an adult. In one embodiment, “adult” refers to an age greater than about 18 years. In another embodiment, “adult” refers to an age greater than about 20 years. In another embodiment, “adult” refers to an age greater than about 25 years. In another embodiment, “adult” refers to an age greater than about 30 years. In another embodiment, “adult” refers to an age greater than about 35 years. In another embodiment, “adult” refers to an age greater than about 40 years. In another embodiment, “adult” refers to an age greater than about 45 years.
In another embodiment, the subject is elderly. In one embodiment, “elderly” refers to an age greater than about 45 years. In another embodiment, “elderly” refers to an age greater than about 50 years. In another embodiment, “elderly” refers to an age greater than about 55 years. In another embodiment, “elderly” refers to an age greater than about 60 years. In another embodiment, “elderly” refers to an age greater than about 65 years. In another embodiment, “elderly” refers to an age greater than about 70 years.
In another embodiment, the first subject, or, where applicable, both the first subject and the second subject, is a laboratory animal. In another embodiment, the subject(s) is/are mice. In another embodiment, the subject(s) is/are rats. In another embodiment, the subject(s) is/are gerbils. In another embodiment, the subject(s) is/are hamsters. In another embodiment, the subject(s) is/are guinea pigs. In another embodiment, the subject(s) is/are rabbits. In another embodiment, the subject(s) is/are pigs. In another embodiment, the subject(s) is/are dogs. In another embodiment, the subject(s) is/are cats. In another embodiment, the subject(s) is/are primates. In another embodiment, the subject(s) is/are any other laboratory animal known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the subject(s) has a disease or disorder comprising balding. In another embodiment, the subject(s) does not have a disease or disorder comprising balding. In another embodiment, the disease or disorder is androgenetic alopecia (AGA). In another embodiment, the disease or disorder is male pattern baldness. In another embodiment, the disease or disorder is female pattern baldness. In another embodiment, the disease or disorder is a discoid lupus erythematosis. In another embodiment, the disease or disorder is a congenital hypotrichosis. In another embodiment, the disease or disorder is a lichen planopilaris. In another embodiment, the disease or disorder is a scarring alopecia. In another embodiment, the disease or disorder is any other disease or disorder comprising balding known in the art.
In another embodiment, the scalp, eyebrow, or scarred region(s) has a majority of HF in the telogen stage of the hair cycle. The findings of Examples 5-6 show that (a) EDIHN can restore hair growth to the scalp, eyebrow, or scarred region at the telogen stage; and (b) the efficiency of EDIHN at the telogen stage can be enhanced by depilation prior to abrasion or wound induction. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 60% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 70% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 80% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 90% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) does not have a majority of HF in the telogen stage of the hair cycle. Each possibility represents a separate embodiment of the present invention.
In another embodiment of methods and compositions of the present invention, the first step (e.g. epithelial disruption) is performed 3-12 days prior to the second step (e.g. addition of an active compound, factor, cell, etc). In another embodiment, the interval is 4-12 days. In another embodiment, the interval is 5-12 days. In another embodiment, the interval is 4-11 days. In another embodiment, the interval is 6-11 days. In another embodiment, the interval is 6-10 days. In another embodiment, the interval is 6-9 days. In another embodiment, the interval is 6-8 days. In another embodiment, the interval is 7-8 days. In another embodiment, the interval is 5-11 days. In another embodiment, the interval is 5-10 days. In another embodiment, the interval is 7-10 days. In another embodiment, the interval is about 1 week. Each possibility represents a separate embodiment of the present invention.
In another embodiment, a method of the present invention further comprises the step of suppressing an activity or expression of a Wnt protein in the scalp, eyebrow, or scarred region. As provided herein, suppressing Wnt activity induces pigmentation in HF generated by methods of the present invention. In another embodiment, the step of suppressing Wnt activity or expression is performed within about 10 days of epidermal disruption. In another embodiment, the step of suppressing Wnt activity or expression is performed prior to the second step (e.g prior to addition of a compound or factor that promotes HF cell differentiation. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a method for inducing pigmentation of a hair, comprising suppressing expression of a Wnt protein in a follicle of the hair. In another embodiment, the Wnt protein is Wnt1. In another embodiment, the Wnt protein is a Wnt7. In another embodiment, the Wnt protein is a Wnt7a. In another embodiment, the Wnt protein is a Wnt3. In another embodiment, the Wnt protein is a Wnt3a. In another embodiment, the Wnt protein is a Wnt10. In another embodiment, the Wnt protein is a Wnt10a. In another embodiment, the Wnt protein is any other Wnt protein known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a method for inducing growth of a pigmented scalp hair or eyebrow of a subject, comprising generating a hair follicle in the scalp, eyebrow, or scarred region according to a method of the present invention and suppressing expression of a Wnt protein in the hair follicle, thereby inducing a growth of a pigmented scalp hair or eyebrow of a subject.
In another embodiment, the step of suppressing expression of a Wnt protein comprises inducing an expression of a Dkk1 protein. In another embodiment, the step of suppressing expression of a Wnt protein comprises inducing an expression of any other Wnt inhibitor known in the art. In another embodiment, the step of suppressing expression of a Wnt protein is performed immediately or shortly after epidermal disruption. In another embodiment, the step of inducing expression of a Dkk1 protein is performed immediately or shortly after epidermal disruption. In another embodiment, the step of suppressing expression of a Wnt protein is performed at the time of epidermal disruption. In another embodiment, the step of inducing expression of a Dkk1 protein is performed at the time of epidermal disruption. In another embodiment, the step of suppressing expression of a Wnt protein is performed several days before generation of the follicle. In another embodiment, the step of inducing expression of a Dkk1 protein several days before generation of the follicle. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 8 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 8 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 9 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 9 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 10 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 10 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 12 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 12 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed during the period of re-epithelialization. In another embodiment, the step of inducing expression of a Dkk1 protein is performed during the period of re-epithelialization. In another embodiment, expression of a Dkk1 protein is halted after several days. In another embodiment, halting expression of Dkk1 protein after several days induces, or enables induction of Wnt protein expression. In another embodiment, the expression of a Wnt protein is induced about 9 days after the abrating or wounding. In another embodiment, the expression of a Wnt protein is induced following the period of re-epithelialization. In another embodiment, induction of Wnt protein expression is necessary for formation of new HF. Each possibility represents a separate embodiment of the present invention.
In another embodiment, “several” refers to about 1 day. In another embodiment, “several” refers to about 2 days. In another embodiment, “several” refers to about 3 days. In another embodiment, “several” refers to about 5 days. In another embodiment, “several” refers to about 7 days. In another embodiment, “several” refers to about 10 days. In another embodiment, “several” refers to about 12 days. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the step of contacting in methods of the present invention comprises directly contacting the scalp, eyebrow, or scarred region with the compound, RNA, protein, etc. In another embodiment, the step of contacting comprises indirectly contacting the scalp, eyebrow, or scarred region via contacting another site or tissue of the subject, after which the compound, RNA, or protein is transported to the scalp, eyebrow, or scarred region by a biological process; e.g, diffusion, active transport, or circulation in a fluid such as the blood, lymph, interstitial fluid, etc. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the epidermal disruption in methods of the present invention further removes dermal tissue from the scalp, eyebrow, or scarred region. In another embodiment, the epidermal disruption does not remove dermal tissue from the scalp, eyebrow, or scarred region. Each possibility represents a separate embodiment of the present invention.
“Disrupting” an epidermis or epidermal layer refers, in another embodiment, to removing part of the epidermis or epidermal layer. In another embodiment, the term refers to disturbing the intactness of the epidermis or epidermal layer. In another embodiment, the term refers to perforating the epidermis or epidermal layer. In another embodiment, only part of the epidermal layer need be removed. In another embodiment, the entire epidermal layer is removed. In another embodiment, the term refers to abrading the epidermis or epidermal layer (Examples). In another embodiment, the term refers to wounding the epidermis or epidermal layer (Examples). Each possibility represents a separate embodiment of the present invention.
In another embodiment, the epidermal disruption is performed with a tool that comprises sandpaper. In another embodiment, the epidermal disruption is performed with a laser. In another embodiment, the laser is a Fraxel laser. In another embodiment, the laser is a CO2 laser. In another embodiment, the laser is an excimer laser. In another embodiment, the laser is any other type of laser capable of inducing trans-epithelial injury. In another embodiment, the epidermal disruption is performed with a felt wheel. In another embodiment, the epidermal disruption is performed with a surgical tool. In another embodiment, the epidermal disruption is performed with any other tool known in the art that is capable of epidermal disruption. In another embodiment, the epidermal disruption comprises use of a micro-dermabrasion device. In another embodiment, the epidermal disruption comprises a burn treatment.
In another embodiment, the epidermal disruption comprises a disruption of a follicle of said epidermis and a disruption of an interfollicular region of said epidermis. In another embodiment, the epidermal disruption comprises a disruption of a follicle of said epidermis and does not comprise a disruption of an interfollicular region of said epidermis. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the epidermal disruption comprises a light-based method. In another embodiment, the epidermal disruption comprises irradiation with visible light. In another embodiment, the epidermal disruption comprises irradiation with infrared light. In another embodiment, the epidermal disruption comprises irradiation with ultraviolet radiation. In another embodiment, the epidermal disruption comprises orthovoltage irradiation. In another embodiment, the epidermal disruption comprises X-ray irradiation. In another embodiment, the epidermal disruption comprises any other type of irradiation known in the art.
In another embodiment, the epidermal disruption is performed by mechanical means. In another embodiment, “mechanical means” refers to abrading. In another embodiment, the term refers to wounding. In another embodiment, the term refers to ultrasound. In another embodiment, the term refers to radio-frequency. In another embodiment, the term refers to an electrical process or the use of an electrical current. In another embodiment, the term refers to electroporation. In another embodiment, the term refers to exision. In another embodiment, the term refers to tape-stripping. In another embodiment, the term refers to microdermabrasion. In another embodiment, the term refers to the use of peels. In another embodiment, the term refers to any other type of mechanical means known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the epidermal disruption comprises chemical treatment. In another embodiment, the chemical is phenol. In another embodiment, the chemical is trichloracetic acid. In another embodiment, the chemical is ascorbic acid. In another embodiment, the chemical is any other chemical capable of epidermal disruption that is known in the art.
Each method or type of method of epidermal disruption represents a separate embodiment of the present invention.
In another embodiment, epidermal trauma is utilized in a method of the present invention.
Each type of epidermal abrasion and epidermal trauma represents a separate embodiment of the present invention.
In another embodiment, the epidermal disruption of methods of the present invention creates an abrasion at least about 1-1.5 centimeters (cm) in width. In another embodiment, the abrasion is at least about 1 cm in width. In another embodiment, the abrasion is at least about 1.5 cm in width. In another embodiment, the abrasion is at least about 2 cm in width. Each type of abrasion represents a separate embodiment of the present invention.
In another embodiment, the scalp, eyebrow, or scarred region is not contacted with a bandage or dressing following the epidermal disruption. In another embodiment, the scalp, eyebrow, or scarred region is not contacted with an ointment following the epidermal disruption. In another embodiment, the scalp, eyebrow, or scarred region is allowed to heal for a period of time without being contacted by any substance, device, ointment, etc., that is ordinarily administered to an abrasion or wound to facilitate healing. In another embodiment, the scalp, eyebrow, or scarred region is allowed to heal for a period of time without being contacted by any substance, device, ointment, etc., that is ordinarily administered to an abrasion or wound to prevent infection. In another embodiment, the period of time is the time it takes the epidermal disruption to heal. In another embodiment, the period of time is any time or range of times between 2 days and 3 weeks. Each possibility represents a separate embodiment of the present invention.
In one embodiment, “following” refers to a period of time of about 2 days. In another embodiment, “following” refers to a period of time of about 3 days. In another embodiment, “following” refers to a period of time of about 4 days. In another embodiment, “following” refers to a period of time of about 5 days. In another embodiment, “following” refers to a period of time of about 7 days. In another embodiment, “following” refers to a period of time of about 10 days. In another embodiment, “following” refers to a period of time of about 2 weeks. In another embodiment, “following” refers to a period of time of about 3 weeks. Each possibility represents a separate embodiment of the present invention.
In another embodiment, a method of the present invention further comprises the step of depilating the scalp, eyebrow, or scarred region. As provided herein, the findings of Example 6 show that the efficiency of EDIHN can be enhanced by depilation prior to abrasion or wound induction.
In another embodiment, the depilation is epilation. In another embodiment, the depilation comprises the step of waxing. In another embodiment, the depilation comprises the step of plucking. In another embodiment, the depilation comprises the use of an abrasive material. In another embodiment, the depilation comprises the use of a laser. In another embodiment, the depilation comprises the use of electrolysis. In another embodiment, the depilation comprises the use of a mechanical device. In another embodiment, the depilation comprises the use of thioglycolic acid. In another embodiment, the depilation comprises the use of any other method of depilation or epilation known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, a method of the present invention further comprises the step of administering a topical retinoid to the scalp, eyebrow, or scarred region. In one embodiment, the topical retinoid induces resting (telogen) BF in the scalp, eyebrow, or scarred region to enter anagen. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the additional step (depilation or administration of a retinoid) is performed prior to the step of disrupting the epidermis. In another embodiment, the additional step is performed following the step of disrupting the epidermis, but prior to the addition of the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell. In another embodiment, the additional step is performed concurrently with the addition of the differentiation-promoting compound or factor. In another embodiment, the additional step is performed following the addition of the differentiation-promoting compound or factor. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the additional step is performed between about two days and about three weeks before the step of abrading. In another embodiment, the additional step is performed about two days before the step of abrading. In another embodiment, the additional step is performed about three days before the step of abrading. In another embodiment, the additional step is performed about four days before the step of abrading. In another embodiment, the additional step is performed about one week before the step of abrading. In another embodiment, the additional step is performed about ten days before the step of abrading. In another embodiment, the additional step is performed about two weeks before the step of abrading. In another embodiment, the additional step is performed about three weeks before the step of abrading. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the methods of the present invention further comprise the step of contacting the scalp, eyebrow, or scarred region with an inductive cell, capable of inducing an epidermal cell to differentiate into an HF cell. In another embodiment, the HF cell is an HF stem cell. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the inductive cell is a dermal papilla cell. In another embodiment, the inductive cell is a follicular papilla cell. In another embodiment, the inductive cell is a dermal sheath cell. In another embodiment, the inductive cell is a cell that has been genetically modified; for example, with a gene encoding a factor that activates one of the proteins or pathways shown in the present invention to be up-regulated in HF stem cells. In one embodiment, the factor is hedgehog. In another embodiment, the factor is a DP cell protein. In another embodiment, the factor is wingless/int (wnt). In another embodiment, the factor is a Noggin protein. In another embodiment, the factor is a bone morphogenic protein (BMP). In another embodiment, the factor is a fibroblast growth factor (FGF). In another embodiment, the factor is a transforming growth factor beta (TGF-beta) protein. In another embodiment, the factor is sonic hedgehog protein. In another embodiment, the factor is a neurotropin. In another embodiment, the factor is any other factor known in the art that can contribute to induction of an epidermal cell to differentiate into an HF cell. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the inductive cell has been genetically modified with a gene encoding a factor that represses one of the proteins or pathways shown in the present invention to be down-regulated in HF stem cells. In another embodiment, the inductive cell has been genetically modified with a gene encoding a factor that activates one of the proteins or pathways shown in the present invention to be up-regulated in HF stem cells upon their activation.
In another embodiment, the inductive cell is an autologous cell. In another embodiment, the inductive cell is an allogenic cell.
In another embodiment, the inductive cell is derived from a mesenchymal stem cell. In another embodiment, the inductive cell is derived from a mesodermal progenitor cell. In another embodiment, the inductive cell is derived from a hematopoietic stem cell. In another embodiment, the inductive cell is derived from an embryonic stem cell. In another embodiment, the inductive cell is derived from an embryonic carcinoma cell. In another embodiment, the inductive cell is one of the cell types disclosed in United States Patent Application No. 2003/0201815. In another embodiment, the inductive cell is any other type of cell known in the art with inductive properties for an epidermal cell. Each type of inductive cell represents a separate embodiment of the present invention.
In another embodiment, the epidermal cell (e.g. the epidermal cell that is induced to differentiate into an HF cell) is an epidermal stem cell. In another embodiment, the epidermal cell is a bulge cell. In another embodiment, the epidermal cell is any other type of cell known in the art that can be induced to differentiate into an HF stem cell. Each possibility represents a separate embodiment of the present invention.
In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an anti-androgen compound. In one embodiment, the anti-androgen compound is finasteride. In another embodiment, the anti-androgen compound is Fluridil®. In another embodiment, the anti-androgen compound is dutasteride. In another embodiment, the anti-androgen compound is spironolactone. In another embodiment, the anti-androgen compound is cyproterone acetate. In another embodiment, the anti-androgen compound is bicalutamide. In another embodiment, the anti-androgen compound is flutamide. In another embodiment, the anti-androgen compound is nilutamide. In another embodiment, the anti-androgen compound is an inhibitor of an androgen receptor. In another embodiment, the anti-androgen compound is any other anti-androgen compound known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an estrogen compound. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region, with an estrogen receptor agonist. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an estrogen analogue. In one embodiment, the estrogen analogue is estradiol. In another embodiment, the estrogen analogue is 17 beta-estradiol. In another embodiment, the estrogen analogue is 17 alpha-estradiol. In another embodiment, the estrogen analogue is ZYC3. In another embodiment, the estrogen compound, estrogen receptor agonist, or estrogen analogue is any other estrogen compound, estrogen receptor agonist, or estrogen analogue known in the art. Each possibility represents a separate embodiment of the present invention.
In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an inhibitor of an EGF protein. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an inhibitor of an EGFR. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a compound that reduces an expression of an EGF protein or an EGFR. Each possibility represents a separate embodiment of the present invention.
In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a Hedgehog protein. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a nucleotide encoding a Hedgehog protein. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an activator of a Hedgehog protein. Each possibility represents a separate embodiment of the present invention.
In one embodiment, a scalp is treated by a method of the present invention. In another embodiment, an eyebrow is treated. In another embodiment, any other hair-bearing area or region of the skin is treated. Each possibility represents a separate embodiment of the present invention.
In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a lithium compound. In one embodiment, the lithium compound contains a lithium ion. In another embodiment, the lithium compound contains a lithium atom.
In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with (2′Z,3′E)-6-bromoindirubin-3′-oxime (BIO). In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with any other compound known in the art that is capable of inducing an epidermal cell to differentiate into an HF stem cell. Each compound represents a separate embodiment of the present invention.
In one embodiment, the compound administered as part of methods of the present invention is administered systemically. In another embodiment, the compound is administered topically. In another embodiment, the compound is administered to the site of the abrasion. In another embodiment, the compound is administered to the site of the wound induction. In another embodiment, the compound is administered to the site of the depilation. In another embodiment, the compound is administered during wound healing. In another embodiment, the compound is administered prior to HF neo-genesis. In another embodiment, the compound is administered during HF neo-genesis. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a method of inducing formation of an HF stem cell, comprising performing a method of the present invention. In another embodiment, the present invention provides a method of inducing formation of a DP cell, comprising performing a method of the present invention. Each possibility represents a separate embodiment of the present invention.
In another embodiment, homologues and variants of transcripts and proteins of the present invention are administered in methods of the present invention. In another embodiment, homologues and variants of transcripts and proteins of the present invention are targeted in methods of the present invention. Each possibility represents a separate embodiment of the present invention.
The terms “homology,” “homologous,” etc, when in reference to any protein or peptide, refer in one embodiment, to a percentage of amino acid residues in the candidate sequence that are identical with the residues of a corresponding native polypeptide, after aligning the sequences and introducing gaps, if necessary, to achieve the maximum percent homology, and not considering any conservative substitutions as part of the sequence identity. Methods and computer programs for the alignment are well known in the art.
In another embodiment, the term “homology,” when in reference to any nucleic acid sequence similarly indicates a percentage of nucleotides in a candidate sequence that are identical with the nucleotides of a corresponding native nucleic acid sequence.
In another embodiment, “homology” refers to identity of greater than 70%. In another embodiment, “homology” refers to identity of greater than 75%. In another embodiment, “homology” refers to identity of greater than 80%. In another embodiment, “homology” refers to identity of greater than 82%. In another embodiment, “homology” refers to identity of greater than 85%. In another embodiment, “homology” refers to identity of greater than 87%. In another embodiment, “homology” refers to identity of greater than 90%. In another embodiment, “homology” refers to identity of greater than 92%. In another embodiment, “homology” refers to identity of greater than 95%. In another embodiment, “homology” refers to identity of greater than 97%. In another embodiment, “homology” refers to identity of greater than 98%. In another embodiment, “homology” refers to identity of greater than 99%. In another embodiment, “homology” refers to identity of 100%.
Protein and/or peptide homology for any amino acid sequence listed herein is determined, in one embodiment, by methods well described in the art, including immunoblot analysis, or via computer algorithm analysis of amino acid sequences, utilizing any of a number of software packages available, via established methods. Some of these packages may include the FASTA, BLAST, MPsrch or Scanps packages, and may employ the use of the Smith and Waterman algorithms, and/or global/local or BLOCKS alignments for analysis, for example. Each method of determining homology represents a separate embodiment of the present invention.
In another embodiment, the present invention provides a kit, comprising a tools and/or a compound suitable for performing a method of the present invention.
In another embodiment, the present invention provides a device, comprising a tool suitable for epidermal disruption and a means of delivering a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell.
In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. Each disease, disorder, or symptom represents a separate embodiment of the present invention.
Pharmaceutical Compositions
In another embodiment, methods of the present invention comprise administering a pharmaceutical composition comprising the HF stem cell-inducing or -activating compound and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof; and a pharmaceutically acceptable carrier. Each possibility represents a separate embodiment of the present invention.
The pharmaceutical compositions containing the HF stem cell-inducing or -activating compound can, in another embodiment, be administered to a subject by any method known to a person skilled in the art, such as topically, parenterally, paracancerally, transmucosally, transdermally, intramuscularly, intravenously, intradermally, subcutaneously, intraperitonealy, intraventricularly, intracranially, intravaginally or intratumorally. Each possibility represents a separate embodiment of the present invention.
In another embodiment, the pharmaceutical compositions are administered orally, and are thus formulated in a form suitable for oral administration, i.e. as a solid or a liquid preparation. Suitable solid oral formulations include tablets, capsules, pills, granules, pellets and the like. Suitable liquid oral formulations include solutions, suspensions, dispersions, emulsions, oils and the like. In one embodiment of the present invention, the HF stem cell-inducing or -activating compounds are formulated in a capsule. In another embodiment, the compositions of the present invention comprise, in addition to the HF stem cell-inducing or -activating compound active compound and the inert carrier or diluent, a hard gelating capsule.
In another embodiment, the pharmaceutical compositions are administered topically to body surfaces and are thus formulated in a form suitable for topical administration. Suitable topical formulations include gels, ointments, creams, lotions, drops and the like. For topical administration, the HF stem cell-inducing or -activating compound or its physiologically tolerated derivatives such as salts, esters, N-oxides, and the like are prepared and applied as solutions, suspensions, or emulsions in a physiologically acceptable diluent with or without a pharmaceutical carrier.
In another embodiment, the pharmaceutical compositions are administered by subcutaneous implantation of a pellet. In another embodiment, the pellet provides for controlled release of HF stem cell-inducing or -activating compound agent over a period of time.
For liquid formulations, pharmaceutically acceptable carriers are, in another embodiment, aqueous or non-aqueous solutions, suspensions, emulsions or oils. Examples of non-aqueous solvents are propylene glycol, polyethylene glycol, and injectable organic esters such as ethyl oleate. Aqueous carriers include, in another embodiment, water, alcoholic/aqueous solutions, emulsions or suspensions, including saline and buffered media. Examples of oils are those of petroleum, animal, vegetable, or synthetic origin, for example, peanut oil, soybean oil, mineral oil, olive oil, sunflower oil, and fish-liver oil.
In one embodiment, the pharmaceutical compositions are controlled-release compositions, i.e. compositions in which the HF stem cell-inducing or -activating compound is released over a period of time after administration. Controlled- or sustained-release compositions include, in another embodiment, formulation in lipophilic depots (e.g. fatty acids, waxes, oils). In another embodiment, the composition is an immediate-release composition, i.e. a composition in which all the HF stem cell-inducing or -activating compound is released immediately after administration.
EXPERIMENTAL DETAILS SECTION
Example 1
Depilation and Epidermal Abrasion Causes De Novo Hair Follicle Formation
Materials and Experimental Methods
Depilation and Epidermal Abrasion
Mice were anesthetized with an injection of sodium pentobarbital before the hair on the back was clipped and depilated with Nair (Carter-Wallace, New York, N.Y.), then epidermis was removed using a rotating felt wheel as described by Argyris T, J Invest Dermatol, 75: 360-362, 1980). After scrubbing with 70% ethanol and drying under an incandescent lamp, the basal and supra-basal layers in an area of (1.5 cm)2 cm of the inter-follicular epidermis were removed by careful abrasion with a felt wheel mounted on a Dremel Moto-tool (Racine, Wis.). After abrasion, the skin was shiny and smooth, and there was no blood. One day later, the abraded area was covered by a fibrin crust, which fell off after 3-7 days, exposing the newly regenerated epidermis. A group of control mice was sacrificed immediately after abrasion to confirm microscopically the complete removal of the interfollicular epidermis.
Immunohistochemistry
Skin samples were fixed in PBS-buffered 10% formalin. Six-micron thick paraffin sections were cut and stained, where applicable, with antibodies.
BrdU Labeling
The protocol described by Bickenbach and colleagues (Bickenbach et al, Cell Tiss Kinet 19: 325-333, 1986; Bickenbach et al, Exp Cell Res 244, 184-195, 1998) was used. Mice were injected with 50 milligrams per kilogram (mg/kg) bodyweight 5-bromo-2′-deoxyuridine (BrdU) every 12 hours for a total of four injections.
Results
An area of the backs of 50-day old mice was subjected to depilation and removal of the epidermis using a rotating felt wheel. Fifteen days later, HF placodes, hair germs and other signs of follicle neogenesis were present (FIG. 1; arrow indicates a hair germ). Morphology of the follicles was similar to embryonic follicle development. To further characterize proliferation in the new follicles, the skin was labeled with BrdU 60 minutes before sacrifice. As depicted in FIG. 2, the proliferation pattern was similar to developing follicles in the embryo.
These findings demonstrate that (a) disruption of the epidermis causes generation of new HF, and that this generation of new HF can occur (b) in adult subjects and (c) during telogen (50-day-old mice are in the second telogen stage of the hair cycle).
Example 2
Induction of a Large Excisional Wound, but not a Small Punch Wound, Causes De Novo Hair Follicle Formation
Materials and Experimental Methods
Punch Wound and Excisional Wound Induction
The backs of 21-day-old mice were depilated as described for Example 1 and sterilized with alcohol, followed by 1% iodine solution. Punch wounds, 4 mm in diameter, were induced using a dermal biopsy punch, down to, but not through, the muscle fascia. Excisional wounds were full thickness and 1 cm in diameter; skin and panniculus carnosus was excised using fine surgical scissors.
Results
To test whether wounding could induce HF formation, punch wounds or excisional wounds were induced in mice. Both types of wounds exhibited contraction and re-epithelialization following wound induction; however, unlike the mice receiving punch wounds, the mice receiving excisional wounds also exhibited scar formation within 10 days of wound induction (FIG. 3, left panel). No follicles were evident at this time point (FIG. 3, right panel). 12 days after wound induction, hair germs, with similar morphology to fetal hair germs, were observed in the wound site, following BrdU pulse labeling (FIG. 4). Several markers were used to verify that the observed structures were HF. The structures exhibited staining with anti-keratin 17 (K 17), an HF marker (FIG. 5), and staining with anti-alkaline phosphatase at the 12 day time point verified that the structures had dermal papilli containing fibroblasts, as expected for HF (FIG. 6; HF at earlier and later stages are depicted in the left and right panels, respectively).
The HF generated by wound induction were further characterized by morphological comparison to embryonic HF, following BrdU staining; a clear correspondence in morphology was observed at various stages (FIG. 7). In addition, several markers of embryonic HF development, namely Lef1, wingless/int (Wnt) 10b, and sonic hedgehog (Shh), were also induced in the epidermal disruption-induced HF neogenesis (EDIHN) (FIG. 8). Additional BrdU staining (FIG. 9) and staining for HF markers S100A3 and S100A6 (FIG. 10; left panel: tissue section parallel to HF axis; right panel: cross-sectional view of follicle) provided further verification that the development of the EDIHN follicles closely paralleled embryonic HF development.
These findings provide further evidence that disruption of the epidermis causes generation of new HF, and that this generation of new HF can occur (b) in adult subjects and (c) during telogen (21-day-old mice are in the first telogen stage of the hair cycle).
Example 3
EDIHN-Induced Hair Follicles Generate Hairs
At 25 and 45 days after wound induction, wound sites contained new hairs (FIG. 11, left and right panels, respectively). New hairs appeared to lack pigmentation, except when the wnt pathway was inhibited, using Dkk-1 (Dickkopf-1) during the first nine days after wounding (see Example 10).
These findings indicate that EDIHN-induced HF function normally; i.e. are capable of generating hairs.
Example 4
EDIHN Hair Follicles Retain the Ability to Enter into Cyclical Hair Growth
Materials and Experimental Methods
BrdU Labeling
50 mg/kg bodyweight BrdU (Sigma) was injected twice per day for 3 days beginning 20 days after wounding. BrdU was detected 40 days after wounding (17 day chase).
Whole Mounting and Immunofluorescence
HF whole mounts were obtained by incubating fresh skin with EDTA (20 mM in PBS) at 37° C. overnight, then separating the epidermis and dermis. Epidermis was then fixed in 10% formalin for 10 min, room temperature (RT). Dermis was fixed in acetone overnight, RT. After rinsing with PBS, whole mounts were stained with antibodies for immunohistochemistry (schematically depicted in FIG. 12) and were imaged using a Leica confocal microscope.
Results
To determine whether EDIHN-induced HF contain normal levels of HF stem cells, mouse skin was examined for the presence of label-retaining cells at 21 days after wound induction. Retention of BrdU during a long chase period is, under these conditions, one of the hallmarks of HF stem cells. Normal numbers and placement of label-retaining cells (in the bulge of the HF) were observed (FIG. 13). To verify that the label-retaining cells were HF stem cells, K15-eGFP mice were utilized. In these mice, eGFP (enhanced green fluorescent protein) is expressed from the K15 promoter; thus, expression of eGFP identifies HF stem cells. As depicted in FIG. 14A, eGFP-expressing cells were observed in tissue sections (right side) of newly formed hair follicles 35 days following wound induction. eGFP-expressing cells were also seen in the epidermis whole mounts (bottom, far left panel) indicating the conversion of epidermal cells into cells with hair follicle stem cell characteristics. ([bottom, second from left] panel is same as [bottom, far left] panel but viewed under white light) This finding shows that the observed label-retaining cells exhibited HF stem cell properties.
To determine whether EDIHN-induced HF cycle normally, mounts were prepared from additional mice at 35, 38 and 45 days after wounding. As depicted in FIG. 14B, the EDIHN-induced HF entered the resting phase, telogen, and then re-entered a new anagen stage.
In summary, the findings of this Example show that EDIHN-induced HF contain HF stem cells, as do embryonically generated HF. The presence of the HF stem cells shows that EDIHN-induced HF retain the ability to enter into cyclical hair growth in the same manner as embryonically generated HF. The findings also show that wounding induces epidermal cells to assume a hair follicle stem cell state (expressing K15-eGFP). This model is shown schematically in FIG. 15. The findings of Examples 2, 3, and 4 show that EDIHN-induced HF are fully functional and thus able to restore hair growth to a subject in need.
Example 5
EDIHN-Induces New Hair Follicles in Mice at the Telogen Stage of the Hair Cycle
To determine whether EDIHN was induced new hair follicles in mice wounded at the telogen stage of the hair cycle, 21-day-old mice were subjected to EDIHN using a 1-cm excisional wound, as described in Example 2. Skin was then examined by whole-mount assay for indications of new HF. As depicted in FIG. 16, after 11 days, new HF were not evident by macroscopic examination (top panel), AP staining of the dermis (bottom left panel), or K17 staining of the epidermis (bottom right panel). After 14 days, as depicted in FIG. 17, dermal papilla cells were detected in the dermis (left panel) and HF stem cells in the epidermis (right panel), demonstrating that new follicles were being formed. After 17 days, the new follicles were more developed, as shown by examination of the dermis and epidermis (FIG. 18, left and right panels, respectively). This method induced formation of an average of 49 new follicles in the wound, a number that was consistent over three separate experiments, as depicted in Table 1.







TABLE 1







Results of three separate experiments performed on 21-day-old mice.












Sample
Expt 1
Expt 2
Expt 3
Avg of expts
Std dev of expts















1
24
70
55




2
29
52
25


3
27
85
53


4
102
25
80


5
53
27
23


Average
47
51.8
47.2
48.67
2.71


Std dev
32.8
26.3
23.7









The findings of this Example demonstrate that EDIHN is capable of inducing formation of new HF in mice at the telogen stage of the hair cycle, despite that fact that these mice do not contain HF at the anagen stage during wounding.
Example 6
In Adult Mice, Induction of Anagen Increases the Efficiency of EDIHN
The experiment described in Example 5 was repeated with mice of different ages, and therefore at different stages of the hair cycle. To ensure that wound scarring occurred, larger wounds were in induced in the older mice. As depicted in Table 2, adult mice at telogen, such as 8-week-old mice, exhibited lower efficiencies of HF formation by EDIHN.







TABLE 2







Efficiency of HF formation by EDIHN in adult mice at various stages


of the hair cycle.













Days after
Mice exhibiting



Age
Wound size
wound
EDIHN
Hair cycle

















3
wk
1
cm
20
25/25
(100%)
Telogen


4
wk
1
cm
20
5/5
(100%)
Early anagen


5
wk
1
cm
20
1/2
(50%)
Anagen


8
wk
1.5
cm
30
16/35
(46%)
Telogen


14
wk
1.5
cm
30
1/2
(50%)
N/A*


20
wk
1.5
cm
30
2/2
(100%)
N/A*





*The second telogen lasts approximately 40 days in mice. Thus, 14-week-old and 20-week-old mice contained a mixture of telogen and anagen HF.






To determine whether experimental induction of anagen increased the efficiency of EDIHN, 8-week-old mice were depilated several days prior to wound induction. As depicted in FIG. 19, the wounds closed similarly whether or not they were preceded by depilation. As depicted in FIG. 20A-B, the depilated mice exhibited enhanced EDIHN relative to the non-depilated mice depicted in the previous Example by a factor of 11-fold.
The findings of this Example demonstrate that anagen induction enhances EDIHN. In addition, these findings show that EDIHN is capable of not only forming new HF, but also of activating anagen in pre-existing HF in the telogen stage.
Example 7
EDIHN-Induces New Hair Follicles in Human Skin Materials and Experimental Methods
Grafting
Discarded human adult scalp from the preauricular area obtained from plastic surgery was grafted onto immunodeficient (scid) mice. The graft was bandaged and allowed to heal, then was used in the wound healing study 3 months after grafting.
Results
To determine whether human skin responded to EDIHN as did mouse skin, human skin was grafted onto SCID (immuno-deficient) mice and subjected to depilation by plucking and wound induction three days later. Seven days following wound induction, formation of new HF was observed in the human skin (FIG. 21A; arrows indicate new HF) by hematoxylin and eosin staining of paraffin embedded tissue sections.
In additional experiments, adult human skin was grafted onto mice, abraded, and examined at 7 days post-abrasion. New HF were generated in the human skin, which mimicked normal hair follicle formation during fetal development, as evidenced by staining for S100A6 or S100A4 (FIG. 21B).
The results of this Example show that EDIHN can be used to generate hair growth in human skin as for mouse skin.
Example 8
Molecular Pathways Activated During HF Stem Cell Activation Materials and Experimental Methods
Isolation and Activation of HF Stem Cells
K15-eGFP mice were depilated in order to induce formation of new HF. Activated hair follicle stem cells were isolated from K15-eGFP mice using fluorescence-activated cell sorting (FACS) two days after depilation and 5 μg (micrograms) total RNA from the cell population was isolated, reverse-transcribed and hybridized to an Affymetrix (Santa Clara, Calif.) array MG_U74v2 chip. Scanned chip images were analyzed using Affymetrix Microarray Suite 5.0 and GeneSpring software (Silicon Genetics) to detect fold-change differences between activated HF stem cells (HFSCs) and non-activated (telogen) HFSCs. Values were normalized before computing fold-changes and differences between non-activated “bs-line” and activated (“expt”) samples.
Results
To identify molecular pathways up-regulated during HF stem cell activation, activated HF stem cells were isolated, and the gene expression patterns of the cells were analyzed to detect up-regulated transcripts. The transcripts depicted in Table 3 were up-regulated at least 2-fold in the activated HF stem cells relative to the cells prior to activation. In some cases, the sequence in Table 3 is a genomic sequence that contains the sequence of the transcript. Data pertaining to the up-regulation of the transcripts and further information about them is provided in FIG. 22.







TABLE 3







RNA transcripts up-regulated during HF stem cell activation.









SEQ ID




No:
Access. #
Sequence












1
AW047343
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2
AF053235
Sequence below.







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cuagccgcauguccuccauccuggcuggaggauccugccgggcucccagcaccugcgggggcaugucaguuaccuccucucg


 


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gacuacagccccuacuucaagaccauugaggaccugaagagcaagaucauuauugccacccaggagaaugcacaguucacuu


 


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auccagagcaaccgcagcgagguggcugagcuccgcaggguguuccagggccuggagauugaacugcagucccagcucagca


 


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gacaaggcuggagcaggagaucgccaccuaccgccgucugcuggauggcgagaauauccacuccuccucacagcacuccucu


 


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gcuucagccagagccaaagucagaguuccagggacuaauguuuugccuagagccuccucacccacaacugccucucaagcug


 


agggcuuggggcaggacccuguuuucuuugcgcauuccccaucugucuccccuacccucucauggugguaggcuaauaaag


 


cuuuuugguugaugcaaaaaaaaaaaaaaaaaa


 









3
M26005
gcgccaguccuccgauagacugagucgcccggguacccguguucucaauaaagccucuug




cuguuugcauccgaaucguggucucgcugguccuugagagggucuccucagauugauugac




uacccacgucgggggucuuucauuuggaggccccagcgagauuuggagaccccugcccaggg




accaccgaccccccgucgggagguaagcuggccagcggucguuucgugucugucucugucuu




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gucggacuuuuuggagcuccgccacuguacguggcuuuguugggggacgagagacagagac




acuucccgcccccgucugaauuuuugcuuucgguuuuacgccgaaaccgcgccgcgcgucug




auuuguuuguuguucuuuuguucuucguuaguuuucuucugucuuuaaguguuuuucgag




aucaugggacagaccguaacuaccccucugaguuuaaccuugcagcacuggggagaugucca




gcgcauugcauccaaccagucuguggaugucaagaagaggcgcuggauuaccuucuguuccg




cugaauggccaacuuucaaugugggauggccucaggaugguacuuucaauuuaaguauuau




cucucagguuaagucuagaguguuuuguccugguccccacggacacccggaucaggucccau




auaucgucaccugggaggcacuugccuaugaccccccuccgugggucaaaccguuugugucu




ccuaaacuuccucccucgccgacagcucccguccucccgcccgguccuucugcgcaaccuccg




ucccgaucugcccuuuacccugcccuuacccccucuauaaaguccaaaccuccuaagccccag




guucucccugauagcggcggaccccucauugaccuucucacagaggaccucccgccguacgg




agcacaaccuuccuccucugccagagagaacgauaaagaagaggcggccaccaccuccgaggu




uucccccccuucucccauggugucucgacugcggggaaggagagacccucccgcagcggacu




ccaucaucucccaggcauucccacuccgcauggggggagauggccagcuucaguacuggccg




uuuuccuccucugauuuaacccuuccuuuucugaagauccagguaaauugacggccuuga


 


4
AA681998
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ggcccacaagcagaucuacuacucagacaaguacuucgaugagcacuacgaguaccggcaugu




cauguuacccagagaacucucuaaacaaguacccaaaacucaucugauguccgaagaggagug




gaggagacuugguguccaacagagucuaggauggguucauuacaugauucaugagccagaac




cgcauauucuucucuuuagacgaccucuuccaaaagaacaacaaaaaugaagugcagcuggga




ucaucuaaucuuuuucaaauuuaauguauauguguauauaagguaguauucagugaauacu




ugaaaaguguacaaaccuuucauccauaccugugcaugcgcuguauucuucacagcaacaga




gcucagucaaaugcaacugcaaguagg


 


5
AF057156
atuaaaaagccagcugcccaaugccugcacacagaauccacaccaacagagaaccugcucuucu




cugaguauuagguaagucucugcuugcaacugauuugaaauucuugcuuauuuuuuuacua




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gaacaguagcauuguuugcuuaaauuauagcacauuuugggucuaggaacuugagagguga




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uucaaauauucauggaaguucacagcuggagacagguuaaggcuucaguccagauagcuuuc




agaauuauugcaguucuuacugauaggcauaucaauagcgaaauuuaauuuauuagaggaau




cuacuaaaguaaauuuuuaggccaauauagaacauaccauacuuguagucuggcagagaagg




ugacauaugaaauugaaaugcgauucauagacagugguagugaaagaaauaaugguggggan




gggcugugcangggaggcauggcucaaggacagcacuuagugguagcacacaccaugaacua




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gcauaaacuaaaagggcaaaagcauaugagcauggacuaacaugcagccacucugcaaguuau




acuaugaucuauuucacaaggagguugguaugcugcugucuuugggugacaccgcuuuccc




agauguccugguguguagguucacaagccucucagaagccauacuuuauugcuuuuuaaga




cguauuauuaauauuuuggcuagcauaugguuuagugugagaguuuuauaugcauauguca




uuauacuuugcucauuuaugucuuggaacuucuucaacuagguagaaaacaugaccagggag




aaugagaguaaggaaagaacccacugagacagacaagagcaaaccauacuucugcuaaucaug




uuuaaaaguccagaaaugaucauaccauauuuuauuuucaaguguggaagucagcauggaga




ggggcucuuuuucucuaaaggggccugaaauuaaauugacuugauguugagguuaccuucu




cuuucaaugaaucacuaaauugucuuuucuguuucccaggacccaagugcuaucuaaccaug




aguucccaccagcagaagcagcccugcacuguaccuccucagcugcaccagcagcaggugaag




cagccuugccagccaccaccccaggaaccuugugcccccaaaaccaaggaucccugccacccu




guuccugagcccugcaaccccaaggggccagagcccugccaccccaaggcacccgagcccugc




caccccaaggcaccugagcccugcaaccccaaggugccagagcccugccagccuaaggugcca




gagcccugccagccuaaggugccagagcccugcaaccccaaggugccagagcccugccaaccu




aaggcaccagagccuugccaccccaaggcgccugagcccugccacccuguuguucccgagccc




ugccccucaacugucacuccaucaccauaccagcagaagacaaagcagaaguaauauugucca




gagccaugccugaagaccugaucaccagaugcugaggcugcugucuauccugcuuaugaguc




ccauugccuugugcuaccaaugcugugaccuucagucuuaaucccucucuccuugcaccacc




uaaaaaguugacucucauccucaucuucaagggcuccugagccucuuaacauugcccaaagu




cauauugaauggcuacacuuuucauggcucaggauucaucugaagggggugaggagugaga




caaguguauggucaauauuuuccccccauuaaaugccauuuaacucc


 


6
AI845584
uuuuuuuuuuuuuuuuuagccaaaauaguuauuuauuaauaauuuaagguuuuacauucu




uauaauaaauuccagcucaaaacuuuacaccacgaacaucauggagcaaguuaauucucccuu




ccucucaaccuguugcauccaccaaaugggcgcucauacucgcacacauacacacacuuccag




uuucguauuuuuuuuuaaaaggaaagaaaccaacccaaaguauugcauuugaggugacacuc




ccugaa


 


7
AA614971
aagaugcccuuuggauuggauuggauugaucauguuuaacucagcguauuuuauggaugaa




agcuaaauacagauauuuggcaucucuaagguggaaugagcccacuccacacacugauaaaau




ucaugcauaguuu


 


8
AV374591
aaccaaaugggaaugggguccccaacnuuncugugguaccagccggguuucucuugcauug




gaaacaaacaccuuuguaggcauuugcguauucgugaagagacuguuuuaugaaucaccucu




uagauuuaunuaauuaaccuaaguuguugaaguuucuguuucuccuuaagagaaauuacaa




aaauucaacauugaagcauaguuucuuguuuucuguugucaaauaguaauaaugugcugug




auguuuaugcuuauucauaaagauguuuuacuuuuuaguguaauguuaguucuuuuuaaca




uuauuuugcuuaaauuugauaaugcccgacaagaauauauuuugcuuugauuuauacacug




auucuuugugacaaauaugacccauuaaaaaugccuuuuaauagacuaacuuaccuuuugua




gcuagguacucauguucuuuuuuaaaagaugcccuuuggauuggauuggauugaucauguu




uaacucagcguauuuuauggaugaaagcuaaauacagauauuuggcaucucuaagguggaau




gagcccacuccacacacugauaaaauucaugcauaguuuuaaaugaacauuaauaaacucaug




uugucuu


 


9
U04443
gaauucaaggaggcuuuccagcuguuugaccgaacaggugauggcaagauccuguacagcca




guguggggaugugaugcgggcccugggccagaacccuaccaacgccgaggugcucaagguuc




uaggaacccccaagagugaugagaugaaugugaagguacuggacuuugagcacuuccugccc




augcugcagaccguggcgaagaacaaggcccagggaaccuacgaggauuauguugaaggccu




ucguguguuugacaaggaaggaaauggcaccgucaugggugcugaaauccgucauguccua




gucacacugggcgagaagaugacagaggaagaaguagagaugcuaguggcagggcaugagga




cagcaaugguugcaucaacuaugaagcauuugugaggcauauccugucggggugacgggccc




gauggggcggagcucguccggauggugcugaauggcugagacauucuguaucccgagucug




uucccugcccagugugauuucuguguggcuccagacgcuccccugucacagcaccuuguccc




auuugguuucuuuggaugauguuugccuucaccaaauaaaauuugcucucuuugccc


 


10
Y07836
caaccaccuccuaccugccugcccaaagcuccagggcuggagcacggagaccugucaggg




auggauuuugcccacauguaccaaguguacaaguccaggcggggaauaaaacggagcgaa




gacagcaaggaaacuuacaaacugccgcaccggcugauugagaaaaagagacgugaccgg




auuaacgagugcauugcccagcugaaggaucuccuacccgaacaucucaaacuuacuacu




uugggucacuuggaaaaagcagugguucuggagcuuacguugaagcacgugaaagcauuga




caaaucuaauugaucagcagcagcagaaaaucauugcccugcagagcgguuuacaagcuggu




gauuugucgggaagaaaucucgaggcagggcaagaaauguucugcucagguuuccagacuu




gugcccgugagguacuucaguaccuggcgaagcaugagaacacucgggaccugaaaucuucc




cagcucgucacucaucuccaucguguggucucggagcugcugcaggguggugcuuccagga




aaccauuggacucggcucccaaagccgucgacuugaaagagaagcccagcuuccuagccaagg




gaucagaaggcccagggaaaaacugugugccagucauccagcggacuuuugcucccucgggu




ggggagcagagcggcagugacacggacacagacaguggcuauggaggugaauuggagaaagg




ggacuugcgcagugaacagccguacuucaaaagcgaccauggacgcagguucgccgugggag




aacgugucagcacaauuaagcaagaauccgaagagccccccaccacaaagagccgaaugcagc




ucucagaagaggaaggccacuucgcgggcagugaucugauggguuccccauuucuugggcca




cacccacaucagccuccuuuuugccuucccuucuaucucaucccaccaucggccacugccuac




cugccuaugcuggagaaaugcugguaccccaccucugugccaguguuauacccaggccucaa




caccucagcugcagcccucuccagcuucaugaacccagacaagauaccgacucccuugcuucu




gccccagagacucccuucuccuuuggcacauucgucccuugacucuucggccuugcuccagg




cuuugaagcagaucccuccuuuaaacuuagaaaccaaagacuaaacucuggagggaucuccu




gcugccuugcuuucuuuccucccuaauuccaaaaaccacgaagguuucccugagugcagaga




gaucagcccacccugcagacccacagagaagauucagagugugugugagagugagugagugu




gcgugcgugcgugcuuguauguauguuuguauauguaggacaauaaguuccuucugacaca




agggagacacgagaaggauagccugacaucagaugacagacuggaggacuguagcacaucuc




ugggcguuucccuacccagagaagagcc


 


11
M21285
Sequence below.







uugcaggcgagggcuuccacaacuaccaccacaccuuccccuucgacuacucugccagugaguaccgcuggcacaucaacuuc


 


accacguucuucaucgacugcauggcugcccugggccuggcuuacgaccggaagaaaguuucuaaggcuacugucuuagcca


 


ggauuaagagaacuggagacgggagucacaagaguagcugagcuuugggcuucugaguuccuguuucaaacguuuucuggc


 


agagauuuaauauucuguugauuaacuaacaacuggauauugcuaucgggguguuaaugaugcauuuaaccuauuccggua


 


caguauucuuauaaaaugagaaagcuuugaucacguuuugagguaauaaauauuuuauuuagcuaggauuaaccaugccac


 


aagacauuauauauuucuaagcacacaugauaaaugcauauacaauuuugcacaacagcuuuaauaauaacaauaaauuug


 


aacauucuauacagagaggaucaaagccaaggaacaugcuguuuugaugcuagggugagcauggugcucagucccuguuug


 


uuugcaugguguccagcuuuguuucuucucugucaucaccaccuucaggcaaauaguugaccaaccacuggccugugucug


 


uccacccuccaaagcccaggccaccuuucuguuuucugaaauacugauccuuccuccugaauacaucccuccuuguuccuag


 


cuucaagacugcugccucaaauagggauagagcaaguccccgcugcagguugugcuagaugggauggagaaauuaucuuca


 


uuugauacagagcaaguagauugucucgagagaaaaguuagcaugcgugguaugauuuguaaguaaagauggaagagagag


 


agagagagagagagagagagagagagagagagagagagguagccauaucuaacagccuacuuaccaaagaccccaggccucuc


 


ugcuuggcaugccuccuuucuguccauccucugaaccccagagauuagugagauuugaauaauuaaaucauuuucagagug


 


aaggggguuaaugcagggucugugcuaggggaggguuuuagcuuuugguaacugaagauuuuuucauggaaaaagucuuc


 


guguucaaugugccuagaacugauaacuaaacagcugacauuugucggggacagauauggugugaaacuaugaaaauauaa


 


gcaaaaucuucacuuggaacaugaaacuauuucacuuagaaaauaaucgaaggacccgagguguugccuggguugccaguuu


 


cuuucguggcugggcaggaacuagugagguugaggggcagugucuguaaguagcugcuaagaggugcauuuccagaugaa


 


gcccuuggggaacaucugccagggauccgcaugguguuggcuccauccauugcuuuaguuuccuccuuggauuguguagaa


 


acuuggcuucccaugguuuugaaccuuccaugccuucuuugcuuuguggccacccagccugccuagugcugccuaggaagc


 


ucuuacccaccugauuucuucugacauuucuuucuuuggccuuuuuuucuuucuccggacaugcagcuaguugccugagu


 


guaucaagagcacccaggacuugcugcuguccaggccuguuccucccccaguauccguggguguggaagagcuguguagcu


 


ucaggaagcagagccaggugccaccuuucuguggcuuccagauccucccuaccuccaacucaugugccucugucacagugau


 


uucaggaaagcuugguagacccucuagcaacaucucgguucagaaagucucucugguuugugaguuaacagcucagcuaag


 


ugcuguuuugucucagugaguuaaccacugaaugcgaggguugguuguugaucugucucggugugugucggaguagacag


 


cauaugcacuucucccugugcgcuuugcaagguaauguggcuuuggcugauccaugcaggcagguagugguacagugcugc


 


ugaaaggaagaaguuccccauuuuaucuguuaaaacaccagagacaugggcaagugcuaauggaccucacuucaggaagagg


 


gucugcuuccugaagccagugugugaugaaaagugacugagaccugauaucuaaggugagaccugauaccuaacacucugu


 


cacacaguccagggccaacagugcuauaggaaagucuagaagaaaacaucacaucaguauuuuagaaccaucaaccaucucuu


 


gucccuauagcccaauccagaggccugguuuuuagaacuggcuguguaaggugccaaacacucaguucacuuguagaaucag


 


agccuuuuuuccccccuauguuaauugaacacgcgcucugagcuguuuuguugaaguagaaaaucucauagaaaaaucacu


 


guagaucuacugaccuauagcccucuggaaaugccuuugagaugguuuuacuuuucuaggucauagaugccugauuauaaa


 


gaugaacaauaaaaucagcuuucuuucuuucucuucugaucuuauuccccagaucugauucaggccauguuccaaagcaagg


 


cuacauugagguccuggugucuuuaaguaaaggacaucuuucagauccucucaaagaaggauuuauaacaguuuccagaug


 


aauguacuaauagcuuugggugccuuaucucuuuccuaaucuguagugccugugagcucagucucacuccuucccuuagcc


 


cggagaccccuuagaucgagugggaaugaucaagaggcuggcuggagagucaucaguacauugguuugcagaaaucuuuua


 


caggcuacauuuuggaauuuuuuuuuuuuuaguaagugaucaaauuuggugggaaguaauucgaguguauucgauuguau


 


ugucguccucguuaucauugucaaacauguuauagacggcaguuggcacuggggcugcuaaucucuggguguagucucuga


 


aacuguagcuccagugagguggugugaaagguuagcaaagccaccaucugcuggugcuccagccaaggugccucuuagccac


 


ugaauugcuauguuauccuuucucuuguaacaaacccaccccagagauaaagccuuuaaucaacccaagaaacuccugggcu


 


aaguaucugacagucucacaucucaacagugugaauuaaguguccauagcaucagcucaggaggacacucugggagagugcu


 


gacaaaaaaggguuauuaauacugaccuacuacuucaagggcaguucugaggugauuagagcuuuuuuuaaaaaccaaguau


 


uuggggauccucagcagagguauucauacagacucccaaagaacuauauauguuccugagaccaucguuuagucuacauugc


 


ucuucccagagacugacagauaugaccagucaaagugcaagacuaccuacccacugccaugaaaaccauugcaggaaaccuuu


 


cccuuccugaaugagauuuuuuuuuucccuuuuuaugugggguaauuauuugugacccaaguguaauuuggaugauuucc


 


auuaauaucaacucuugaagccuacuuguacugauugagauuguauuuguuccuaauaaaaguggaucugguuguacuguc


 









12
V00756
accacuugcagacaaaugaauuccuucgaaauguauuugagguuggacccccugugaugcuu




gaugcugcaacacuuaaaaccaugaagauuucucguuuugaaaggcauuuauauaacucugc




agcuuucaaagcucgaacaaaagcucgaagcaaaugccgagauaagagagcagauguuggaga




auucuuguagaugucugaauuugauggcuguuuucuaaucucuuccuuuauuauuauuuu




ugcuacuucuaauguauauaagcuuuuagagacaguuuuuuaucuuggucaacuuaaauaa




uuuuugauguagggguggguuguauuuuaauuuaauguacaguguuacaaauuaaugagu




ucuuuauucucuguaaaaauaacugguaaccacaaauaaaguguuugugauguuuggucgu


 


13
Y14296
auguccgcggccgccuacauggacuucguggcugcccagugucugguuuccaucuccaaccg




cgccgccgugccggagcacgggggcgcuccggaagccgagcggcugcgacuaccugagcgcg




aggugaccaaggaacacggugacccgggggacaccuggaaggauuauugcacgcuggucacu




aucgccaagagcuuguuggaccucaacaaauaccgacccauccagacccccucggugugcagc




gacagucuggagagucccgaugaggauauaggauccgacagcgacgugaccaccgaaucugg




gucgaguccuucccacagcccggaggagagacaggauucuggcagcgcgcccagcccacucuc




ccuccuccacucuggaguggcuucgaaggggaaacacgccuccgaaaagaggcacaagugccc




cuacaguggcugugggaaagucuauggaaaauccucccaucuuaaagcccauuacagagugc




auacaggugaacggcccuuucccugcacguggccagacugccuuaaaaaguucucgcgcucg




gaugagcugacccgccacuaccggacccacacuggggaaaagcaguuccguugcccacugug




ugagaagagauucaugaggagugaccaucucaccaagcaugcccggcgucacaccguguucc




aucccagcaugaucaagagaucaaaaaaggcucuugccugccccuugugaggugcuccccau




ggcagccaggcagagauggguccccggaaggacagagcucccaggaaacagacugacacaugg




aaaucugccacagcagaggcgcgcuggccacaggaggucacugcuucuuuggccaauauucu




gauaucucccugcacuguuuccaaaaagcacaugguagcccuaaggucaaagucaacauuug




guccccuugcagaggcaacucugaaccgucucugacugaagauucagacuggugguguacau




acgucunacugggugaguugaccccuggccucccacagugcagaaccacucucuugaaucac




auuaacuuuugagauuuaaaaaaaacccaaacccaacccnncaaaacnccaganacaccgaaac




ucuggauccucgaugcuugcugacucucagaauugnuunuucuucucanuuaugcaagcna




gagcacaccuacuccagcaugauuugucaucuaaagacuugaaaacaaaacaacaacaacana




aaguuacuuauagucaauggauaagcagaguccgaauuuacacuaaucaagacagaccuucg




aggggucacgauaaguccggaacuuucaaaccuugcuucguaugaauuguacuaucugaaca




uaaacugcacuuuuauuuucuaauaccgagggugaauacgguaaauacaugcuuugagggu




agaanccgacggucuguuuggcaccacguuauaaucugcunnuuuuaacgaguaccaccuug




gagggcaggcaaauaaaugcuuuuggguauuuucuccuuuguuuuugacaaaugcugcgga




ugggggaucgggaucggaggggagugcuuuuaaagauaauaaaaaaugagguaaauaauuu




uaacuuaugaauuuguuugaauuc


 


14
X16490
gagauugaaacaauggaagaacuuuccauggcaaacaccauguuugcccucaaucuccuu




aagcagauagaaaaaucaaacucuacccagaacaucuuuaucucuccauggagcaucuca




ucaacauuggccauaguucuccucggugcuggggguaacacugaacagcagauggccaaa




gugcugcaguuuaaugaaauuggcaguuaugguaucaccacaagaaacccagagaacuuc




aguggcugugauuucgcacaacagauacagaaggaaaauuauccuagugcuauuuuacaggc




acaagcaggagauaaaauccauucagccuucuccucucucagcucaacaaucaacaca




ccacagggggauuauuuguuagaaagugcaaacaagcuguuuggagagaagucugcaagauu




caaagaagaauacauccaacucucuaagaaauauuacucaacagaaccagaagcagug




gacuuccuugaaugugcugaagaagcuagggaaaagauuaauucuugggucaagacucaaac




caaaggugaaaucccaaaccugcuacccgaagguucuguagaugaagacaccaagauggugc




uggugaaugcugucuacuucaaaggaaaguggaaaacuccauuugagaagaaacuuaauggg




cuuuauccuuuccgugugaacucgcaugagagcauaccuguccagaugauguuccuccaugc




aaagcugaacauuggauacauaaaggaccugaagacucagauccuagaacuuccgcauacugg




aaacaucagcaugcuccuguugcuucccgaugagauugaggacgcauccacuggcuuggaau




ugcuggaaagugaaauaaacuuugccaacuucaacaaguggaucagcaaagacacacuggau




gaagaugauguuguggucuacauucccaaguucaaacuggcacaaagcuacgaacucaaguc




cauucuucaaagcaugggcauggaggaugccuucaacaagggcaaggccaacuucucaggaa




ugucugagaggaaugaccuuuuucuuucugagguguuccaucaagccagcguggaugucac




cgaggagggcacuguggcagcuggugggacuggggcaguuaugacaggaagaacuggccau




gguggcccacaguuuguggccgaucaucccuuucuuuucuuuaucauggacaaaauuaccca




cacgauacuauuuguugguagauucuccucacccuaaaaggggaagaccuauuuccacauga




gguuuuguagcaugaacuauaagccucagaauugcaucuucaagugccaaaaguuuaaauac




uuucuuacacauuuuuauacuucugcuauacacuaaauauaaccuaaaagcaauuguauagc




agucuucagugcuuacaguauaacucuauuaaugauuuuguuuccuaaagucagaugaugu




cuauuuaguucauccuuauuacugcuuugucuuuauaacuuuaguuuuuacaguguuauu




uauuguuuauauaaugguuguuuuacaaauuguuguccucuguuuaaugaaacuguaacac




uacagaagcagaaaauuagauaauuuucuauuuaaagaaaaucagccauuuaauuuaauaau




gaaggaaaaauaugagucuuccauacuuucccaugauauucacccagaaaaaauguacuuaac




aaaagacauguuauaucucuaucauuauauaucauauguacguaucugcaacucaucuauaa




uuaggacuacaucauaaguaagcaugcuuacuuacacacugcuaucuguuguauaaaacuua




gcaauccuuauuuguuaguuaucuuucuaucacuguaacaaaauaccugagauaauaaaguu




caaagauuuauuuugaaaaaaaaaaaa


 


15
AW120868
uuuuuuuuuuuuuuunuaagaauuaacuuuuauuuuugcuuaguuuuauuaaaaaaauaa




auaugucauaaagcuuuuguuuccuuuagggagaaaaaaaaggaacaaguuccauaaaauca




aacaagcaaugguaacaugucuuaacuugaaaacaacuggggucacugguuuacaaguuaua




acugaaugaaugacugccacaguugcccauuuccuccugccaauggcagcaaacaacaggauc




aacuagggcaaaauaaauaauuguguggaagcccuga


 


16
C78850
aacuaaacuuccuuguaacuuuugagaacucagcucugguacuuuuucaugccuugcaaaau




ggcguuanugcagcuagcuugcuaanccuuaugguggggucuuucauuccccccucuuucu




ggaaacugnauaaaaucauuuauucacgugauucuauuucuucuggaucuauugauuugag




uuggugauacuguugggucanaaccagggccuguu


 


17
D67076
Sequence below.







gcagcuccgagcuaggugcuaucgcaaggccagagcgcacagcccggcggagagagcagauccuugcucagaucgagucaaa


 


ucgggccaaggcggaggacgaagaguccaggcuccuauucuggacuuguuccccagcuccgggggcgcuucuagguccugc


 


agcagccagcagugcggagccaccaacucggugcuggaaugaaaaaauucccgcgcgccagugcagaaucuuucuaagugac


 


ccggagcuucgggugcuagcucugcacgaacuuucccaucaaagugaucgugaauuuuaagcaucaggagcaggccagcgaa


 


gcucuacgcgucuaaacgucuauccagaccaagaguucucugcggugcagggugcggugccaugcagccaaaagucccuuuu


 


ggggucacgcaagcagaagcccugcuccgacaugggggacguccagcgggcagcgagaucucggggcucucuguccgcacac


 


augcuguugcugcuccucgcuuccauaacaaugcugcuaugugcgcggggcgcacacgggcgccccacggaggaagaugagg


 


agcugguccugcccucgcuggagcgcgccccgggccacgauuccaccaccacacgccuucgucuggacgccuuuggccagca


 


gcuacaucugaaguugcagccggacagcgguuucuuggcgccuggcuucacccugcagacuguggggcgcagucccggguc


 


cgaggcacaacaucuggaccccaccggggaccuggcucacugcuucuacucuggcacggugaacggugaucccggcucugcc


 


gcagcccucagccucugugaaggugugcguggugccuucuaccuacaaggagaggaguucuucauucagccagcgccugga


 


guggccaccgagcgccuggccccugccgugcccgaggaggagucauccgcacggccgcaguuccacauccugaggcgaaggc


 


ggcggggcaguggcggcgccaagugcggcgucauggacgacgagacccugccaaccagcgacucgcgacccgagagccagaa


 


cacccggaaccaguggccugugcgggaccccacgccucaggacgcgggaaagccaucaggaccaggaagcauaaggaagaagc


 


gauuuguguccagcccccguuauguggaaaccaugcucguagcugaccaguccauggccgacuuccacggcagcggucuaaa


 


gcauuaccuucuaacccuguucucgguggcagccagguuuuacaagcaucccagcauuaggaauucaauuagccugguggu


 


ggugaagaucuuggucauauacgaggagcagaagggaccagaaguuaccuccaaugcagcucucacccuucggaauuucugc


 


agcuggcagaaacaacacaacagccccagugaccgggauccagagcacuaugacacugcaauucuguucaccagacaggauuu


 


auguggcucccacacgugugacacucucggaauggcagauguuggaaccguaugugaccccagcaggagcugcucagucaua


 


gaagaugaugguuugcaagccgccuucaccacagcccaugaauugggccauguguuuaacaugccgcacgaugaugcuaagc


 


acugugccagcuugaauggugugaguggcgauucucaucugauggccucgaugcucuccagcuuagaccauagccagcccu


 


ggucaccuugcagugccuacauggucacguccuuccuagauaauggacacggggaauguuugauggacaagccccagaaucc


 


aaucaagcucccuucugaucuucccgguaccuuguacgaugccaaccgccagugucaguuuacauucggagaggaauccaag


 


cacugcccugaugcagccagcacauguacuacccuguggugcacuggcaccuccgguggcuuacuggugugccaaacaaaac


 


acuucccuugggcagauggcaccagcuguggagaagggaaguggugugucaguggcaagugcgugaacaagacagacauga


 


agcauuuugcuacuccuguucauggaagcuggggaccauggggaccguggggagacugcucaagaaccuguggugguggag


 


uucaauacacaaugagagaaugugacaacccagucccaaagaacggagggaaguacugugaaggcaaacgaguccgcuacagg


 


uccuguaacaucgaggacuguccagacaauaacggaaaaacguucagagaggagcagugcgaggcgcacaaugaguuuucca


 


aagcuuccuuugggaaugagcccacuguagaguggacacccaaguacgccggcgucucgccaaaggacaggugcaagcucac


 


cugugaagccaaaggcauuggcuacuuuuucgucuuacagcccaagguuguagauggcacucccuguaguccagacucuacc


 


ucugucugugugcaagggcagugugugaaagcuggcugugaucgcaucauagacuccaaaaagaaguuugauaaguguggc


 


guuuguggaggaaacgguuccacaugcaagaagaugucaggaauagucacuaguacaagaccuggguaucaugacauuguca


 


caauuccugcuggagccaccaacauugaagugaaacaucggaaucaaaggggguccagaaacaauggcagcuuucuggcuau


 


uagagccgcugaugguaccuauauucugaauggaaacuucacucuguccacacuagagcaagaccucaccuacaaagguacu


 


gucuuaagguacagugguuccucggcugcgcuggaaagaauccgcagcuuuaguccacucaaagaacccuuaaccauccagg


 


uucuuaugguaggccaugcucuccgacccaaaauuaaauucaccuacuuuaugaagaagaagacagagucauucaacgccau


 


ucccacauuuucugagugggugauugaagaguggggggagugcuccaagacaugcggcucagguuggcagagaagaguagu


 


gcagugcagagacauuaacggacacccugcuuccgaaugugcaaaggaagugaagccagccaguaccagaccuugugcagac


 


cuuccuugcccacacuggcaggugggggauuggucaccauguuccaaaacuugcgggaaggguuacaagaagagaaccuuga


 


aaugugugucccacgaugggggcguguuaucaaaugagagcugugauccuuugaagaagccaaagcauuacauugacuuuu


 


gcacacugacacagugcaguuaagaggcguuagaggacaagguagcguggggaggggcugauacacugagugcaagaguac


 


uggagggauccagugagucaaaccaguaagcagugagguguggcaaggagguguguguaggggauacauagcaaaggaggu


 


agaucaggacacuacccugccaguuacauucugauaagguaguuaaugaggcacaguagcaucugaaagaccauacagagca


 


cuaaggagccccaaagcacuauuaguaucucuuuucuuauaucuaucgcccaaauaauuuucagagucuggcagaagcccug


 


uugcacuguacuaacuagauacuucuuaucacaaagauugggaaaggcaaagcagaaagaugguaagacuggguuucaaaca


 


aggcuugguuucaaucacuggaggcaaggaggaggggacaaacaagaucauuauucgaagucgcugguugcugugguuuua


 


cggaagguugaugcaucauuccuaucaacagugaaaaguucagcuuguucaacgugacagaaaggcucaucuccgugaaaga


 


gcuccugauuucuucuuacaccaucucaguucuuaacuauaguucauguugagguagaaacaauucaucuauuuauaaaau


 


guacauuggaaaaaaaaagugaaguuuaugagguacacauaaaaacugaaggaaacaaugagcaacaugccuccugcuuugc


 


uuccuccugagguaaaccugccuggggauugagguuguuuaagauuauccauggcucacaagaggcagaaaauaauacau


 


guugugccagaguuagaaugggguauagagaucagggucccaugagauggggaacauggugaucacucaucucacauggga


 


ggcugcugcag


 









18
M61007
ccgcgggcccgcguucaugcaccgccugcuggccugggacgcagcaugccucccgccgcc




gcccgccgccuuuagacccauggaaguggccaacuucuacuacgagcccgacugccuggc




cuacggggccaaggcggcccgcgccgcgccgcgcgcccccgccgccgagccggccauugg




cgagcacgagcgcgccaucgacuucagccccuaccuggagccgcucgcgcccgccgcgga




cuucgccgcgcccgcgcccgcgcaccacgacuuccucuccgaccucuucgccgacgacua




cggcgccaagccgagcaagaagccggccgacuacgguuacgugagccucggccgcgcggg




cgccaaggccgcgccgcccgccugcuuuccgccgccgccucccgccgcgcucaaggcgga




gccgggcuucgaacccgcggacugcaagcgcgcggacgacgcgcccgccauggcggccgg




uuucccguucgcccugcgcgccuaccugggcuaccaggcgacgccgagcggcagcagcgg




cagccuguccacgucgucgucguccagcccgcccggcacgccgagccccgccgacgccaa




ggccgcgcccgccgccugcuucgcggggccgccggccgcgcccgccaaggccaaggccaa




gaagacgguggacaagcugagcgacgaguacaagaugcggcgcgagcgcaacaacaucgc




ggugcgcaagagccgcgacaaggccaagaugcgcaaccuggagacgcagcacaaggugcu




ggagcugacggcggagaacgagcggcugcagaagaagguggagcagcugucgcgagagcu




cagcacccugcggaacuuguucaagcagcugcccgagccgcugcuggccucggcgggcca




cugcuagcgcggcgcgguggcguggggggcgccgcggccaccgugcgcccugccccgcgc




gcuccggccccgcgcgcgcgcccggaccaccgugcgugcccugcgcgcaccugcaccugc




accgaggggacaccgcgggcacaccgcgggcacgcgcggcgcacgcaccugcacagcgca




ccggguuucgggacuugaugcaauccggaucaaacguggcugagcgcguguggacacggg




acuacgcaacacacguguaacugucuagccgggcccugaguaaucaccuuaaagauguuc




cugcgggguuguugauguuuuugguuuuguuuuuguuuuuuguuuuguuuuguuuuuuu




uuuuggucuuauuauuuuuuuuguauuauauaaaaaaguucuauuucuaugagaaaagagg




cguauguauauuuugagaaccuuuuccguuucgagcauuaaagugaagacauuuuaauaa




acuuuuuuggagaauguuuaaaagccaaaaaaaaaa


 


19
C85523
aaaauguagaaggcaagauuuaauaaggcagcaacaugaaagcacacagaccagagcucu




ggggucgaaauaaagcagcaacauggaagcacacagagcucuggggucgaaacucauaca




ccuuagcacaggguagaggagucucgacggucanccagaauuuuucacaggcuuauauag




uaaaacucaaagggggagaacugggcagggaaaguacaaguuuacaucacuagggaguuc




ugccaaaggacaanggguucunucagaggaaucuacguaacuaaggngucauguccuauc




aaggnaucuacguaacuaaggagucauguccuaucauuuggcaauguacccgnucuuuu




gagguuguuccggagggncuuauucucaaaauguuuuucagauuggaagggguggguunc




cgguaaaaaguucuguuuucaaagaggcnguaauuuucuauucuucauuccccauucucc




uguaaguauucnnaucuuagaauuucagaaguccauauucncuauguggggaauaacugg




cuuuaacccnaucuuuaaaauggggg


 


20
AW122030
uuuuuuuuuuuuuuuuuaugaaacaguuuuguucagcccaugacuuugugcaugacuguc




guccguucuagucaccugugcucuccaucuacugccuuuuaaagcugcgucaugagaagg




aucuacacguuccaccaugacucucguuucuugccacaaguagaagaaaugguugauucu




uugcuuuucgguuaggccguuaaacaaaacucagucacaccccugccuuccacccucaaa




cugugaucacguggcuguucuuguaguunaaccagggcaacacuauauauuccaggucua




uacauugcugaggucuuuuucugguuguucauguaucaguguuuucaaccucgugccg


 


21
U57524
Sequence below.







gcggccgcggcuccagaccccggccuugcgcacccuccccccaccuccagcccgcgccucccccccccccacgcauggcucacc


 


accccucggguuucccugucaucccucagguuccugcacuuggcaaucauccacgaagagaagccgcugaccauggaaguca


 


uuggucaggugaagggagaccuggccuuccucaacuuccagaacaaccugcagcaggugcgcugcuugcuugccccgcggu


 


gccccucuuugaccccuugguggagucagauguagcacggucgcccccaaagcguuucuaaauuaauagucacuuaguucu


 


uaucugccuuggcuuuuuugcauucaaaucagccaacgucuuagaaccagaagaaaaaucccuugguuuuagugaggucuu


 


uaugacccaccuagggccuccuguuugccugaucuccuaagagacaaaugggaggaucagauuccauagcgggaggugucu


 


gggguucaggaaacucaagacuauggguuugcuccauggcuuaucccuuucuguuuccucuuccauuuguagacuccacuc


 


cacuuggcugugaucaccaaccagccaggaauugcugaggcacuucugaaagcuggcugugauccugagcuccgagacuuuc


 


gaggaaauaccccucuacaucuugccugugagcagggcugccuggccaguguagcagucuugacgcagaccugcacacccca


 


gcaucuccacuccguccugcaggccaccaacuacaaugguaggucugccaguccauccaaggaugcagaggagggagagaga


 


uggggccacuugagucuuaaacuccgaacguauacaaaguucagacacugugaucuuuuuaaaaaguuuucuccucgaugcc


 


uauaugauauucacucagaacccagauucugaguucuucaaaacugaugauguuugugguuguccucaagacaauagacau


 


gaguugugugaggauugaaacacguaguacaguuuuugucuuccuccuccaggccacacgugucugcaccuagccucuacu


 


cacggcuaccuggccaucguggagcacuuggugacuuugggugcugaugucaacgcucaggugaguacaucucccuuccac


 


cuaaucucuguugggcuggcucugauggugagcagguuuccagaugcagccguaaacuaacgccugauugcuuuugguuuc


 


aggagcccugcaauggccggacagcccuccaccuugcgguggaccugcagaauccugaccugguuucgcucuuguugaaaug


 


uggggcugaugucaacaggguaaccuaccaaggcuacucccccuaccagcuuaccuggggccgcccaaguacccggauacag


 


cagcagcugggccagcugacccuggaaaaucuccagaugcuacccgagagcgaggaugaggagagcuaugacacggagucag


 


aauucacagaggaugaggugaguguuccuccccucagcacgcugacggcuguucuagggcugcuuuggaucagagggauuu


 


caguuguuuaacuucucagacucggcuugcaaagcaggaucccaagaauuugucucugguuuguuuuaagagcuuacccuu


 


uugguugaggaaugagggaauucuagaaauugaacccaggccuuagcacauggugauaagcacacguucaaccauuaagcuc


 


cacccccucaauagcuuagacuuuuuuuuuuuuuaaggaaagaauagguaagggaaacuccuacagccuggugcccuuguu


 


cuauuuggguuaaggagaaaaagagcccaagaauaggaguuauuucagcagcagcucuccccuuaucccaaugucuugguga


 


aguucuaggaauuuaauaugucuuuuuccccucucuuguuuuagcugcccuaugaugacuguguguuuggaggccagcgu


 


cugacauuauaaguggaaaguggcaaaaaagaauguggacuuguauauuuguacaaauagaguuuuauuuuucuaaaaaaa


 


aaaaaaaaaaaaaaaaaaaaaaaaaaaaguauacuuagcaccacaccacacagcgccuagacccaggcauuuuacuggggugau


 


ucggcuguugucuuugugaaauccgggg


 









22
U05809
cucucggucacugccggucgcuuccugagccgcugcuggcucugugucucuguccucagc




guucucuuccucguccucguccuaccacgccauggaagguuaccauaagccagaucagca




gaagcuccaggcccugaaggacacagccaaucgccugcgcaucagcuccauccaggccac




caccgcggcaggcucaggccaccccacaucaugcugcagcgcugccgagaucauggcugu




ccuguuuuuccauaccaugcgcuacaaggcccuggauccccgaaacccucacaaugaucg




cuuugugcucucuaagggccaugcagcucccauuuuauaugcagucugggcugaagcugg




cuuccugcccgaggccgagcugcugaaccugaggaagaucagcucugacuuggacgggca




uccugucccgaaacaagccuucaccgauguggccacuggcucccugggccagggccuggg




agcugcuugcgggauggcauacacaggcaaauacuuugacaaagccagcuaccgagucua




uugcaugcugggagacggggaggucuccgagggcuccgucugggaggccauggccuuugc




uggaauuuacaagcuggacaaccucguugccauuuuugacaucaaccgccugggccagag




cgacccagccccgcugcagcaccagguggacaucuaccagaagcgcugugaggccuuugg




cuggcacaccaucaucguggacggacacagcguggaggagcugugcaaggccuuugguca




ggccaagcaccaaccaacagccaucaucgccaagaccuucaagggccgagggaucacagg




gauugaagacaaggaggcguggcacgggaagccccuccccaaaaacauggccgagcagau




uauccaggagauuuacagccagguucagagcaaaaagaagauccuggccacgcccccuca




ggaggaugccccauccguggacauugcuaacauccgaaugccuacgccacccagcuacaa




agugggggacaagauagccacccggaaggccuauggacuggcccucgcuaagcugggcca




cgccagugaccguaucauugcccuggauggagacaccaagaauuccaccuucucggagcu




cuucaaaaaggagcacccagaccgguucauugagugcuacauugccgagcaaaacauggu




gagcauugccgugggcugugccacacgugaccggacagugcccuucugcaguacuuucgc




ggccuucuucacacgggccuucgaccagauucgcauggccgccaucucugagagcaacau




caaccucuguggcucccacugugguguguccauuggggaagacgggcccucucagauggc




ccucgaagaccuggccauguuccggucaguccccauguccaccgucuuuuacccaagcga




uggaguugcaacagagaaggcaguggaguuagcagccaacacaaagggcauuugcuucau




ccggaccagccgcccagagaaugccauuauuuauagcaacaaugaggauuuccaggucgg




ccaagccaaggugguccugaagagcaaggaugaccaagugacagugaucggggcuggugu




aacucugcaugaggccuuggcugcugcagagagucuaaagaaagauaagaucagcauccg




ggugcuggaucccuucacuaucaagccccuggacaggaaacucauccuagacucugcccg




agcaaccaaaggcaggauccucaccguggaggaccacuacuacgaagguggcauaggaga




ggcagugucugcugccguagugggugaaccuggagugacggucacucgccuggcugucag




ccaaguaccacgaaguggcaagccagcugagcuacugaagauguucgguauugacaagga




cgccauugugcaagcugugaaaggccuugucaccaagggcuagggagggcaugggaugcu




gggugggugaacuacacauuccagggagguucuggcagagguggcgaagguguacugagu




ggggagguaaauauauguuuug


 


23
AW212475
uuaacggugucauaaauaaguaauauaacuuuauuaaaaugaaaagacaauauucaaaau




aaugcaacaaaaugaauaaauccuuuguccaauacuguacacacagugcggagaucagug




cauuuuucuaaagcauguuuuaaccuucauuuaguucauacuaaaguaagcuuuaaauag




cucaaauaaugucauucagcaguuuaaacugaacagcuuguugggacaug


 


24
V00835
ugaguucucguaaacuccagagcagcgauaggccguaauaucggggaaagcacuauaggg




acaugauguuccacacgucacaugggucguccuauccgagccagucgugccaaaggggcg




gucccgcugugcacacuggcgcuccagggagcucugcacuccgcccgaaaagugcgcucg




gcucugccaggacgcggggcgcgugacuaugcgugggcuggagcaaccgccugcugggug




caaacccuuugcgcccggacucguccaacgacuauaaagagggcaggcuguccucuaagc




gucaccacgacuucaacguccugaguaccuucuccucacuuacuccguagcuccagcuuc




accagaucucggaauggaccccaacugcuccugcuccaccgguaagacucccgauccuug




gucuuuagaauaccaaguugggaccgcagagcggaauccccgaguuguagaggcuuggcg




ggaauaggcaccuuuaguuggcgauucauuccgguucuuucuagaauccgcucuugcaaa




agccuucauuaguuacgaguauugucgaacggguccuuuggcgggguuggggcuaggauu




uagacgcgcaaauguccgguuccugaucacccaguuaguggggacaucuggguugagucc




caggcauuacuaaacuuacugugaauugcuugaauuaagaaagaggugaaggaccuuuau




gucuugggacucaaagacauaaucccugacuuaaccugugaggagaaaaguggggcuagg




cucccugcagcuccgaggaggacuuagugaacugagccgggacucgugguguuggccacu




gcuguaaugcugccucccucaugcugucuucuuucuccucccaggcggcuccugcacuug




caccagcuccugcgccugcaagaacugcaagugcaccuccugcaagaagagugaguuggg




acaccuuggguggcggcuaaggcuaggggcggggaacuccuacaaaacuggcucugagaa




auguccuuugcuucccggaggccauuguauugucucggggacagaacuauacagagaacu




auuuaaaaaaaccgaggucuucucuguuggggacaggaagcagaggucuucagccaggcu




gccucuuccuccuucuucuaggcugcugcuccugcugucccgugggcugcuccaaaugug




cccagggcugugucugcaaaggcgccgcggacaagugcacgugcugugccugaugugacg




aacagcgcugccaccacguguaaauaguaucggaccaacccagcgucuuccuauacaguu




ccacccuguuuacuaaacccccguuuucuaccgaguacguuaauaauaaaagccuguuug




agucuaacucugguuucuuggugugguuuggcaauaagaaacuggggugacuugauaguc




uggggaucugguuuuggacccccucgugccuuuaccuccgcccucuggcccucacagagg




gguaaugucuuuggguaaagccaagcuauaucccauaagcuuccucauggaaaacagcug


 


25
AV374868
gcggcacgaugugucuucggguggcuuuuuuuuuuuuguuuugaauaauguuuacaauuu




cccucaaucacuuuuauagaaauccaccuccaggccccccccuuuccccacuuaggccuu




cgaggcugucugaagaugcuugagaaacucaaccaaaucccaguucaauucagacuuugc




acauauauuuauauuuauaaucagaaaagaaacauuucaguaauuuauaauaaaagagca




cuauuuuuuaacg


 


26
M21285
See above (same Accession Number).


 


27
U74683
acugccaucgagugguguuccaguugaacuugcucucucugccaucugcuccgcgggcgc




cgucagcaugggucccuggacccacuccuugcgcgccguccugcugcuggugcuuuuggg




agucugcaccgugcgcuccgacacuccugccaacugcaccuacccugaucugcugggcac




cuggguguuccaggugggcccuagaaguucccgaagcgacauuaacugcucggugaugga




agcaacagaagaaaagguagugguacaccuuaagaaguuggauacugccuacgacgagcu




gggcaauuccgggcauuuuacccucauuuacaaccaaggcuucgagauuguguugaauga




cuacaaaugguuugcguuuuucaaguaugaagucagaggccacacagcuaucaguuacug




ccaugagaccaugacuggguggguccaugaugugcugggccggaacugggcuugcuuugu




uggcaagaagguggaaagucacauugagaagguuaauaugaaugcagcacaucuuggagg




ucuccaggaaagauauucugaaagacucuacacucacaaccacaacuuugugaaggccau




caauaccguucagaagucuuggacugcaacugcauauaaggaauaugagaaaaugagccu




gcgagaucugauaaggagaaguggccacagccaaaggaucccaaggcccaaaccugcccc




gaugacugaugaaauacagcaacaaauuuuaaauuugccagaaucuugggacuggagaaa




cguccaaggcgucaauuauguuagcccuguucgaaaccaagaaucuuguggaagcugcua




cucauuugccucuauggguaugcuagaagcaagaauucguauauuaaccaacaauucuca




gacaccaauccugaguccucaggagguuguaucuugcagccccuaugcccaagguuguga




ugguggauucccauaccucauugcagggaaguaugcccaagauuuuggggugguggaaga




aagcugcuuucccuacacagccaaagauucuccaugcaaaccaagggagaauugccuccg




uuacuauucuucugacuacuacuaugugggugguuucuaugguggcugcaaugaagcccu




gaugaagcuugagcuggucaaacauggacccauggcaguugccuuugaaguccacgauga




cuuccuacacuaccacaguggaaucuaucaccacacugggcugagugacccuuucaaccc




cuucgagcugacaaaucaugcuguuuugcuugugggcuauggaagagauccaguuacugg




gauagaauacuggauuauaaagaacagcuggggcucuaacuggggggagaguggcuacuu




ccguauccgcagaggaacugaugaaugugcaauugagaguauagccguggcggccauacc




gauuccuaaauuauaggacauagcucccaguguuacauacgggucuuuaucacucacaga




gugauuuagucacaugcugaagacuuuuucagagcaauaucagaagcuuaccacuaagca




ucuuuaaagaauuuugucuuugaacuuaaaaccauccuugauuuuuuucuuuuaauaucu




uccccaucaacuacugaacuacuuuucuuuuuaaaguacuugguuaaguaauacuuuuau




gagcagugguucaguuguccaauauuuuuugcaggucaucuacaaugcaaccagauguuu




caguucuaaaaaucuauguaaaaguacaagcucguuuuuaaauuauguaagucacaugaa




aacauggcaaaaaaauuaguuaaauuuuuuacaaagaguuuuaaauaaauguuuauguaa




ucaguaccauagucuuucuauguguguuuacaagaauuuuugucaccuacuucuucccuu




agaagcauuuaugcuccauggacguacuucuuuauggagaaaaaaaaaa


 


28
X61800
gagcucgaucccuguuccgccuuugcuaugucugaaggcguccugcuuugcgcgugucgg




ggccaaauccagauuuucauuucgcuccaggcuuggacggcuaaguagguccaaaccgca




caaacaggaaggagggaaggcaaggagugcgggcagagggcgggucguucccagcagcac




cccagucccuccccgcuccgucuccgacccacuggggccggggcgggcgugcgcgucagc




uggggcuagaaaaggcggcgguccggcccggcgaggugacagccaacuuggacgccaggu




ccggccgacgccgccaugagcgccgcgcuuuucagccuggacagcccggugcgcggcaca




cccuggcccacagaacccgcggccuucuacgagccaggcaggguggacaagcccggccga




gggcccgagccaggggaacugggggagcugggcuccacgacuccugccauguacgacgac




gagagcgccaucgacuucagcgccuacauugacuccauggccgccgugcccacccuagag




cugugccacgacgaacucuucgccgaccucuucaacagcaaccacaaagcggccggcgcg




ggcggccuggagcugcugcagggcggcccuacgcgacccccggguguggggucugucgcu




agggggccgcucaagcgcgaacccgacuggggcgacggcgacgcgccgggcucccugcug




ccggcgcaaguggcggugugcgcgcagacaguggugagcuuggcggccgcggcucagccc




acuccacccacuucgccggagccuccucgaggcagcccggggccgagccucgcgcccggc




acaguccgagaaaagggcgcgggcaagagggguccggaccgcggcagcccggaguaccgg




cagcggcgcgagcgcaacaacaucgcugugcgcaagagccgcgacaaggccaagcgccgc




aaccaggagaugcagcagaagcugguggaguugucggccgagaacgagaagcugcaucag




cgcguggagcagcucacccgggaccuggcuggccuccggcaguucuucaaaaaacugccc




agcccgccuuuccugccgcccaccggcgccgacugccgguaacgcgcggcgugggccuuu




gagacucugaacgaccuauaccucagaccccgacagcggggagcagacgccgcccgaauc




gcuaguuucuuugggaccugcgagcgacaggaagcugcagcuugggcacuggacugcgag




agaagcuauauuaaucuuuccccuuaaauuauuuuuuauaaugguagcauuuucuacguc




uuauuaccauugcagcuaagguacauuuguagaaaagacauuuccgacagacuuuuguag




auaagaggaagagacugcgcaugcuuuuuauauucauuuuuacaguauuuguaagaauaa




gaauaagaauaaagaagcauuuaaaucgcaaaaaaaaa


 


29
U20735
Sequence below.







uugaggguggccaggccagcguaggaggccagcguaggauccugcugggagcggggaacugagggaagcgacgccgagaaa


 


gcaggcguaccacggagggagagaaaagcuccggaagcccagcagcgccuuuacgcacagcugccaacuggccgcugccgacc


 


gucuccagcucccgaggacgcgcgaccggacaccggguccugccacagccgaggacagcucgccgcucgccgcagcgagcccg


 


gggcggcccuucagggggaccuuucccagaucgcccaggccgcccggaugugcacgaaaauggaacagccuuucuaucacga


 


cgacucuuacgcagcggcgggauacggucggagcccuggcagccugucucuacacgacuacaaacuccugaaacccaccuug


 


gcgcucaaccuggcggaucccuaucggggucucaaggguccuggggcgcgggguccaggcccggagggcaguggggcaggc


 


agcuacuuuucgggucagggaucagacacaggcgcaucucugaagcuagccuccacggaacuggagcgcuugaucgucccca


 


acagcaacggcgugaucacgacgacgcccacgccuccgggacaguacuuuuacccccguggggguggcagcgguggagguac


 


agggggcggcgucaccgaggagcaggagggcuuugcggacgguuuugucaagcccuggacgaccugcacaagaugaaccac


 


gugacgccccccaacgugucccugggcgccagcggggguccccaggccggcccagggggcgucuaugcugguccggagccgc


 


cucccgucuacaccaaccucagcaguuacucuccagccucugcacccucuggaggcuccgggaccgccgugcggacugggag


 


cucauacccgacggccaccaucagcuaccucccacaugcaccacccuuugcgggcggccacccggcacagcuggguuugaguc


 


guggcgcuuccgccuuuaaagaggaaccgcagaccguaccggaggcacgcagccgcgacgccacgccgccugugucccccauc


 


aacauggaagaccaggagcgcaucaaaguggagcgaaagcggcugcggaacaggcuggcggccaccaagugccggaagcgga


 


agcuggagcgcaucgcgcgccuggaggacaaggugaagacacucaaggcugagaacgcggggcugucgagugcugccgguc


 


uccuaagggagcaaguggcgcagcucaagcagaaggucaugacccaugucagcaacggcugccaguugcugcuaggggucaa


 


gggacacgccuucugagagccucccuugccccauacggacacccccagccuugaaggcugggcgccugccccccacuggggu


 


gaggggggcaggcgaugggcacccgccaaaaggccuggggcgcagcucacacacuggacuccggcccgcccgccugcgccca


 


guccuuccaccucgagguuuacauggcccccuuccagcguauuuuguauguuuuuuuuuucugcaaagagacugaauucau


 


auugaauauaauauauuuguguauuuaacaggagggagaagggggcugucgcggcggagcuggccgccgcuugguacucag


 


cugcggggauacuagggagggaccuccgcccccugcccucccccucugcauaguacuguggagaagaaacacgacuucgugu


 


cuaaagucuauuuuaagauguguuuguguguguguguuugacuuuuuauugaaucuauuuaagua


 









30
U19118
Sequence below







gaauucggcacgagcagcgagacgccgcgcacggugcuuccccaguggagccaaucggcuaacccgcgcuccggcagagucc


 


uuggcgcucgcccgccggcgggacagaccacccgccucuggccgcucucuggacccuggccgccccgagcgaagacuggagc


 


aaaaugaugcuucaacauccaggccaggucucugccucagaagucagugcgaccgccauuguccccugccucucaccuccug


 


ggucacugguauuugaggauuuugcuaaccugacacccuuugucaaggaagagcugagauucgccauccagaauaaacaccu


 


cugccaucggauguccucugcgcuggagucaguuaccgucaacaacagaccccuggagaugucagucaccaagucugaggcg


 


gccccugaagaagaugagaggaaaaggaggcggcgagaaagaaauaaaauugcugcugccaagugucgaaacaagaaaaagga


 


gaagacagagugccugcagaaagagucagagaaacuggagagugugaaugcugagcugaaggcccagauugaggagcugaag


 


aaugagaaacagcauuugauauacaugcucaaccugcaccggcccaccuguaucguccgggcucagaauggacggacaccgg


 


aagacgagaggaaccucuuuauccaacagauaaaagaaggaacauugcagagcuaagcagagguggcacggaggcaauuggg


 


gaguucuuacugaauccuccuuuuccaccccacacccugaagccauuggaaaacuggcuuccugugcacuucuagaauccca


 


gcagccaagagccguuggggcaggagggccuguggugaccuacugcauugacccacucugcccccgagugaaccguggagca


 


ggcaggagcauccuuugucucaccaauuccaggauuuaggccuuaucaucccggccagucucagaugaccuagcuggcccca


 


ggcugggguccuaugcaaagcaggaucccacuaaugggauucaggcagaagugucuaccuugauagguggggugggaccac


 


auccucuacuguggcugacaacgcccuuccaagggaauauggaaugagaacauucauuauugagguuguccaauggccaggg


 


uaugcuuucuagaaaauaugcuguucugucccagaaugacugugcauaggguauccguuucagagccugguguugugcuau


 


uuagauguuugucuugcacaacauuggcaugauuuuuccgggaguuucaucagaucugauuucugagagucuggggaucu


 


gccaugguggaaagugccccucaaaagcauuuguguggccacaugaacuggcuggcaccaggggagugaaacuggcugauga


 


ccagcugagccacuuugugccaacagaggauggacgacaccuuucccuguacccacugcagaggaagaacccugggcacagca


 


gcuuuguccuuggcuacaaacuguuacaacgucacacaaugaaggcacaaaguccaacuuucaaaggguguaggacuccaua


 


cucagugacagggcaggaagagccaaagauaaccacagccacagccuguggagaccaggguuggaagccaggugcagggcca


 


ggcaucugcauugugggauguuaauggcacuuuugucuuguagcuauuuugagaugugguccagagcauuucagcuggga


 


gaucucccucuggccaccaggacucuggcuacuguuaaaauccugauguuucuguggaauccucaguguuuaaucccacuca


 


auaguaucauuacaguuuucuguaagagaaaauauuacuuauuuaucccaguauuccuagccugucaacauaauaaauaucg


 


gaacaaaaccuggua


 









31
AW049031
uuuuuuuuuuuuuuuuugcugauaagaauucuuuuuauguuauucgaauaaaaaauaca




uucauacagaaauauaacaaucucgcaaaaaacaauuucaaauaaaaucuuguaaaacaaa




auuuuacaaaaaucuuacaaagauucuuuagauaacagggugcuucaaaaaaaaagaaau




aaagaaauuucacuaauagaaauuuuuuuuuuuaauuucaagcaaaaguuccugcuugau




ugaggcucaguugucaccugaccagaauggacugcuuaguauuaaaguuacagcaucgac




acggacggcacccagccccagccagaccagcaacgucgcuguguuucauaagugagacgc




gccagcacaaguuuccucucucuucuguuuaccuucuuacuuaauggaauugcuauggau




aagcacacagcagggccaaaaaaggaguuuuccaaaauccagcaaaucaagug


 


32
M93275
uaguggugaucuggaccgugcggacuugcucgucccucagcucuccuguuaggcgucucu




uuucuccaggaggaaaaaauggcagcagcaguaguggauccgcaacagagcguggugaug




agaguggccaaccugcccuuggugagcucuaccuacgaccuuguguccuccgcuuauguc




aguacaaaggaucaguacccguauuugagauccgugugugagauggccgagaagggcgug




aagaccgugaccucugcggccaugacaagugcccugcccaucauccagaagcuggagcca




caaauugcgguugccaauaccuaugccugcaaggggcuagacaggauggaggaaagacug




ccuauucugaaccagccaacguccgagauuguugccagugccagaggugccguaacuggg




gcgaaggauguggugacgacuaccauggcuggagccaaggauucuguagccagcacaguc




ucaggggugguggauaagaccaaaggagcagugacuggcagcguggaaaggaccaagucu




guggucaauggcagcaucaauacaguuuuggggauggugcaguucaugaacaguggagua




gauaaugccaucaccaagucggagaugcugguagaccaguacuucccucucacucaggag




gagcuggagauggaagcaaaaaagguggaaggauuugauaugguucagaagccgagcaac




uaugaacggcuggagucccugucuaccaagcucugcucucgggcuuaucaccaggcucuc




agcaggguuaaagaggccaaacaaaagagccaggagaccauuucucagcuccacuccacu




guccaccugauugaauucgccaggaagaauaugcacagugccaaccagaaaauucagggu




gcucaggauaagcucuaugucucguggguggaguggaagagaagcaucggcuacgacgac




accgaugagucccacuguguugagcacaucgagucacguacucuggcuaucgcccgcaac




cugacccagcagcuccagacuacaugccagacuguccuggucaacgcccaaggguuacca




cagaacauucaagaucaggccaaacacuugggggugauggcaggcgacaucuacuccgua




uuccgcaaugcugccuccuuuaaggaaguguccgauggcguccucacaucuagcaagggg




cagcugcagaaaaugaaggaauccuuagaugaaguuauggauuacuuuguuaacaacacg




ccucucaacuggcugguaggucccuuuuauccucagucuaccgaggugaacaaggccagc




cugaagguccagcagucugaggucaaagcucaguaaaccccuccuugucaccagagcaug




auguugcuggccagaugaccccuuuugcuguauugaaauuaacuugguagauggcuuuag




cuuagaaaagcagcuucuuagaaccaagggccucauuauggucacucacagcucaguuau




ggucuugccccagcuggcccuggcacaggaguucucuuaccuggcuggugaguggccugu




guuagucuugugaggaccuggaggaaccuaaaagcucagaugcacuuacagucuugucug




uggccuuuguauuguuauuggcuguaaacgucugucuggaccgaauaaagauucacguga


 


33
AB000713
ggcacgagggagcugcaguguucgcgcuugguagcuggugcaucggacucagcuggcuuu




gugucccugaggcucaccgaaaaacacuuucucagcccucugacuccagagagagagaga




gagagguacuuuuuguggucaccgacuuugaccccugcagaggcugagcgauggcgucua




ugggacuacagguccugggaaucuccuuggcaguccugggcuggcuggggaucauccuga




guugugcgcuccccauguggcgggugaccgccuucaucggcagcaacaucgucacggcac




agaccagcugggagggccucuggaugaacugcguggugcagagcacaggucagaugcagu




gcaagauguacgacucgaugcucgcccugccgcaggaccugcaggccgcccgagcccuua




uggucaucagcaucaucgugggugcucuggggaugcuucucucagugguagggggcaagu




gcaccaacugcauggaggacgagaccgucaaggccaagaucaugaucaccgccggagccg




uguucaucguggcaagcaugcugauuauggugcccguguccuggaccgcucacaacguca




uccgcgacuucuacaacccuaugguggcuuccgggcagaagagggaaaugggggccucgc




uuuacgucggcugggcggccuccgggcugcugcuccugggaggaggccuccucugcugca




guugcccaccucguagcaacgacaagcccuacucggccaaguacuccgccgcccgcucug




uccccgccagcaacuauguguaaggugggccacucuguccacauugccuuuguuauuuuu




uuucggauugagcucauaacagccuguggccccucacauucuccaggaccugcccugcua




ugggccacuaacugcuugcuggggacaggcaaacccggacugugcaaaguuacuagcccg




uagcucuugggcugcuccacauggcuccuuacggccggcaagaauggauguaaaaauauc




uugcugcuuacauccaaauugcgguggauaugggcugaaggcagaagcagcugggaaggg




caguagaggcgcaagcuggguccugcuggccgggguagcucagcugugacuuuggacucg




gaguggauguccucauguuagcaaacguccacuguccuuucucuaucccccucacucagc




cuacacguuacuccagcgcuacucuugccauuacgccccguguuuccgagcacagcuggu




ccuaccccaagucauggugugcugagugacugaugaggggccauugagagccggugggcu




cugccauggaacccuuccguugauuagcaaugacugugcuugacccacccaccuacccua




cuaaugaauuucuguagaguggauggacggguuugagggaagaaggguggagguggauu




aaacugguuuggggagggcuggggaccuagaagcagcccaguguguccccaccccuuuucc




gcacugucuugcuaauguucugaucacugugcgcccccucccucuucagaaggacccugg




gccucuugaguuggccccucugaguucccucccuuugcccauuucaaggacaccggccag




ucugcggaaggaagguacggggggggggggggggggugauggcauuguaccagggaguc




uccuggacuccccugccuucucugugguuucuuguuuuguaauuaaggucuguucacagc




uguaauuauuauuauuuucuacaauaaauggcaccugcauacag


 


34
U20735
See above (same Accession Number).


 


35
U83148
augcagcugagaaaaaugcagaccaucaaaaaggagcccgcaccccuagauccuaccagc




agcucagacaagaugcugcugcugaacucugccuuagcugagguggccgaggaccuagcc




ucaggugaagauuugcuccugaacgaagggagcauggggaaaaacaaauccucggcgugu




cggagaaaacgggaauucauuccggacgagaagaaagacgccauguauugggagaaacgg




cggaaaaacaacgaagcugccaaaagaucucgggagaagcgccgccucaaugaccugguu




uuggagaacaagcugauugcccugggagaagaaaaugccacuuuaaagcugagcugcuc




ucccugaaauuaguuugguuuaauuagcuccacggcguaugcccaagaaauccagaaa




cucaguaauuccacagcugucuacuuucaggacuaccagacauccaaggcugccgugagc




ucuuuuguggacgagcaugagccugcgaugguagccggaaguugcaucucagucaucaag




cacucuccccagagcucgcucuccgaugugucagagguguccucgguggagcacacucag




gaaagccccgcacagggaggcugccggagcccugagaacaaguucccugugaucaagcag




gagcccguggaguuggagagcuuugccagggaggccagggaggagcggggcacguauucc




accuccaucuaccagagcuacaugggaagcucuuucuccacuuacucccacuccccaccc




cucuugcagguccauggguccacuagcaacuccccaagaaccucagaggccgaugagggu




guagugggcaagucuucugauggggaagacgaacaacaggucccuaagggccccauccau




ucuccaguggagcugcaacggguucacgccacgguggugaagguuccggaagugaacccu




ucugccuuaccgcacaagcuucggauuaaagccaaggccaugcaggucaaaguggaggcu




uuggacagcgaguuugaaggcaugcagaaacucucuucacccgccgaugcgaucgccaaa




agacauuuugaccuggagaaacauggaaccucggguauggcccauuccucccucccuccu




uucucagugcaggugacgaacauucaagauuggucccucaaaucggaacacuggcaucac




aaagaacugagcagcaaaacucagaguagcuucaaaacaggugugguggaagucaaagac




gguggcuauaagguuuccgaagcugagaauuuguauuugaagcagggaauagcaaacuua




ucugcagagguggucucgcucaagagauucauagccacacaaccgaucucggcuucggac




uccagguaa


 


36
L10244
gcucccgggaaacgaaugaggaaccaccuccuccugcuguucaaguacaggggccuggug




cgcaaagggaagaaaagcaaaagacgaaaauggcuaaauuuaagauccguccagccacug




ccucugacugcagugacauccugcgacugaucaaggaacuggcuaaauaugaauacaugg




aagaucaagucauuuuaacugagaaagaucuccaagaggauggcuuuggagaacaccccu




ucuaccacugccugguugcagaagugccuaaagagcacuggaccccugaaggacauagca




uuguuggguucgccauguacuauuuuaccuaugacccauggauuggcaaguugcuguauc




uugaagacuucuucgugaugagugauuacagaggcuuugguauaggaucagaaauuuuga




agaaucuaagccagguugccaugaagugucgcugcagcaguaugcacuucuugguagcag




aauggaaugaaccaucuaucaacuucuacaaaagaagaggugcuucggaucuguccagug




aagagggauggaggcucuucaagauugacaaagaguacuugcuaaaaauggcagcagagg




agugaggcgugccgguguagacaaugacaaccuccauugugcuuuagaauaauucucagc




uucccuugcuuucuaucuuguguguagugaaauaauagagcgagcacccauuccaaagcu




uuauuaccagugacguuguugcauguuugaaauucggucuguuuaaaguggcagucaug




uaugugguuuggaggcagaauucuugaacaucuuuugaugaagaacaaggugguaugauc




uuacuauauaagaaaaacaaaacuucauucuugugagucauuuaaauguguacaauguaca




cacugguacuuagaguuucuguuuugauucuuuuuuuuuaaauaaacucgcucuuugau




uu


 


37
U88328
cgcuggcuccgugcgccauggucacccacagcaaguuucccgccgccgggaugagccgcc




cccuggacaccagccugcgccucaagaccuucagcuccaaaagcgaguaccagcuggugg




ugaacgccgugcgcaagcugcaggagagcggauucuacuggagcgccgugaccggcggcg




aggcgaaccugcugcucagcgccgagcccgcgggcaccuuucuuauccgcgacagcucgg




accagcgccacuucuucacguugagcgucaagacccagucggggaccaagaaccuacgca




uccagugugaggggggcagcuuuucgcugcagagugacccccgaagcacgcagccaguuc




cccgcuucgacuguguacucaagcuggugcaccacuacaugccgccuccagggacccccu




ccuuuucuuugccacccacggaacccucguccgaaguuccggagcagccaccugcccagg




cacuccccgggaguacccccaagagagcuuacuacaucuauucugggggcgagaagauuc




cgcugguacugagccgaccucucuccuccaacguggccacccuccagcaucuuugucgga




agacugucaacggccaccuggacuccuaugagaaagugacccagcugccuggacccauuc




gggaguuccuggaucaguaugaugcuccacuuuaaggagcaaaagggucagaggggggcc




ugggucggucggucgccucuccuccgaggcacauggcacaagcacaaaaauccagcccca




acggucgguagcucccagugagccaggggcagauuggcuucuuccucaggcccuccacuc




ccgcagaguagagcuggcaggaccuggaauucgucugaggggagggggagcugccaccug




cuuuccccccucccccagcuccagcuucuuucaaguggagccagccggccuggccuggug




ggacaauaccuuugacaagcggacucuccccuccccuuccuccacacccccucugcuucc




caagggagguggggacaccuccaaguguugaacuuagaacugcaaggggaaucuucaaac




uuucccgcuggaacuuguuugcgcuuugauuugguuugaucaagagcaggcaccuggggg




aaggauggaagagaaaagggugugugaaggguuuuuaugcuggccaaagaaauaaccacu




cccacugcccaaccuaggugaggagugguggcuccuggcucuggggagaguggcaagggg




ugaccugaagagagcuauacuggugccaggcuccucuccauggggcagcuaaugaaaccu




cgcagaucccuugcaccccagaacccuccccguugugaagaggcaguagcauuuagaagg




gagacagaugaggcuggugagcuggccgccuuuuccaacaccgaagggaggcagaucaac




agaugagccaucuuggagcccagguuuccccuggagcagauggaggguucugcuuugucu




cuccuauguggggcuaggagacucgccuuaaaugcccucugucccagggauggggauugg




cacacaaggagccaaacacagccaauaggcagagaguugagggauucacccagguggcua




caggccaggggaaguggcugcaggggagagacccagucacuccaggagacuccugaguua




acacugggaagacauuggccaguccuagucaucucucggucaguagguccgagagcuucc




aggcccugcacagcccuccuuucucaccuggggggaggcaggaggugauggagaagccuu




cccaugccgcucacaggggccucacgggaaugcagcagccaugcaauuaccuggaacugg




uccuguguuggggagaaacaaguuuucugaagucagguauggggcuggguggggcagcu




guguguugggguggcuuuuuucucucuguuuugaauaauguuuacaauuugccucaauc




acuuuuauaaaaauccaccuccagcccgccccucuccccacucaggccuucgaggcugucu




gaagaugcuugaaaaacucaaccaaaucccaguucaacucagacuuugcacauauauuuau




auuuauacucagaaaagaaacauuucaguaauuuauaauaaaagagcacuauuuuuuaau




gaaaaaaaaaaaaaaaaaaaaaaaaaa


 


38
X82786
Sequence below.







aaggaaucuucaguacagaaacaagacccaaguguaaguuuaacuggcaggaggaaccaaccaaggacaguuaaggag


 


aaaacccaacccuuagaagaacucaccaguuuccaagaggaaacugccaaaagaauaucuuccaaaucuccacaaccgg


 


aagagaaggaaaccuuagcagguuuaaagaggcagcucagaauacaacuaaucaacgaugguguaaaagaagagccca


 


cagcacagagaaagcaaccauccagggaaaccaggaacacacucaaagagccuguaggugacaguauaaauguugaag


 


agguuaagaagucuacaaagcagaaaauugauccaguagcaagugugccugucagcaagaggccacggaggguaccc


 


aaggaaaaggcacaggcccuagaauuggcuggucucaaaggaccaauccaaacccuaggccacacugaugaaucagca


 


agugauaaaggacccacacagaugcccuguaauucucuacaaccagagcaaguugacagcuuccaaagcucaccaagg


 


cgacccaggacaagacgugggaaaguagaggcagaugaagagccuucagcaguaagaaagacaguaucaacaucaagg


 


caaacuaugcgaucccgcaaggucccugaaauugguaacaaugguacccaaguuucaaaggccuccauaaagcagaca


 


uuagauacaguagccaaaguaacuggcagcaggaggcagcuaaggacacauaaaggaugggguucaacccucuugaa


 


guuguuaggugacuccaaagaaauaacccaaauaucagaucacucugagaaacuagcacaugacaccaguauccuuaa


 


gagcacucaacagcaaaagccagacucaguaaaaccucugagaacaugcagaagagugcugagggccucuaaagaggu


 


ccccaaggaaguguugguggacaccagagaccaugcaacauuacaaagcaaaagcaacccuuugcuguccccgaagag


 


gaagucugcaagagauggaagcauugugagaaccagggcuuugcgcucuuuagcaccaaagcaggaagcaacagaug


 


agaagccuguaccugagaaaaaaagggcugcuuccagcaagagguauguaucaccugagccugugaagaugaaacacc


 


ugaaaaucgugucaaacaaacuugaaucuguggaagagcagguuagcacuguuaugaaaacagaagaaauggaagcc


 


aaaagagaaaauccugucacuccagaucagaacucuagguaccgaaagaaaaccaauguaaaacagccaaggcccaagu


 


uugaugcaucugcagagaaugucgggauaaagaaaaacgagaagacuaugaagacugccucccaggagacagagcug


 


cagaauccagaugauggagccaagaaaucuacaucucggggccaagucagugggaaaagaacaugcuugaggucuag


 


aggaacgacugagaugccccagccuugugaagcagaagagaaaacaagcaaaccagcugcagaaaucuugauaaagcc


 


ucaggaagagaaaggagucucuggagagucugauguuagguguuugagguccagaaaaacuagagucgcuuuggac


 


agugaaccuaagccaaggguaacucguggaaccaagaaagaugcaaaaacucugaaggaggaugaagacauuguaugc


 


accaagaaguuaagaacaagaaguuaagaacaagaaguuaccagaaaagugaaacuauguagcaaagacauuuaagaa


 


ggaaaaguaaauuugacuuagugauaaguuccagugugguuuucaccuccaguguaaagaugaacuguaaauacuac


 


ugcuacugccugaguuuaaggaaggaagcuuugagcuuuccuggucauacucucuucagacgccaauggaggucau


 


gaggaagaucaccagggaucucagcgcaauuacaguuuaggggugagcaggcagaaauguggcccucuguccuaucc


 


aauaaagcucugaaauucgcugccaaaa


 









39
AW122523
uuuuuuuuuuuuuuuuuaaaucaaaaguuaugaugacuuuauuuuaaaucuuaauacacc




aaaaauauuuuucaauguugugagauaagcacuugaaaauaagaauuccaacacugcugu




gauuucgcugugaggcuugauagugaauuuucccucugaauauggguuuagggccuagga




agcagaaugccagucauuuuccaaguagcagugagcuaagcccagcccggucaugcucag




acccacacuuaacugaaauauucacacuaggaggcggcaccaccaggcaacaccuugauc




aaccaggagaacaaaagucugaagugccaccaagcauuggggaaaugauauuguuuagau




gcuagugagucagguucuuucaaauguguccuaacuggguugcaaacauaguugcauccu




uau


 


40
AI642048
gucuguaaaaaucuguuuaauaaauauacaucuuagaaguaccaaaauaauuaccaacaa




aauacaacauauacaacauuuacaagaaggcgacacagaccuuaguugggggcgacuuuu




aagcacaugccacugaacaccuggcucuuacaugggaggacacacugggcucacuuacua




ggucuauggugguucaaucaaaagcacaauaaauaaaacgugguccuuucauuagguucu




ggaaaaucaccucccccccccccaaaaaaaaucccacaaacaugaaccuuaagagacauu




uucuuugaauuucagugaucuguuuccccggauuucacaaagacaacagccgaaucaccc




caguaaaaugccugggucuaggcgcugugugguguggugcuaaguauacccuuucucauu




uuuuuucuuuuucu


 


41
L07264
cggccgccagaccuucaagggcuggaguggacgcgcggaccgacucugaacagacagacg




aaccgcggccgcaagguucccagacaggaucucacccagaggcaggcagcggacagugcc




uuaguggaaccucgcuguccuccaccgccuggccccggugcaggcguccaguggccgccg




cauccaaagugaucgcugccuccccgucuccgccagcucgggaccaugaagcugcugccg




ucggugaugcugaagcucuuucuggccgcaguguuguccgcguuggugaccggugagagu




cuggagcggcuucggagaggucuggcggcagcaaccagcaacccugacccucccacugga




uccacaaaccagcugcuacccacgggaggugaucgugcucaggggguccaggacuuggaa




gggacagaucugaaccuuuucaaaguugcuuucuccuccaagccacaaggccuggccacc




ccaagcaaagaaaggaaugggaaaaagaagaagaaaggaaagggguuagggaagaagaga




gacccaugccucaggaaauacaaggacuacugcauccacggggagugcagauaccugcag




gaguuccguacucccucuugcaaaugccucccugguuaccacggacacaggugucauggg




cugacucuaccaguggagaauccccuauacacauaugaccacacuacagucuuggcugug




guggcuguaguacugucguccgucugucuucuugucaucgugggacuucucauguuuag




guaccacaggagaggagguuaugacuuggaaagugaagagaaagugaaguugggcguggc




uagcucccacugaggaggaccugagcuauaggaaccuucagaggcuacuucugagacagug




guucguuacacguucuacauagaggagaaauauuucaccagcagccaugaaaacgucuuc




auucauuuccaguugcuacccugacugggccuccuguaau


 


42
M15668
ucgaccucacggucuugccaaaaugucgcuuuccaacaagcugacuuuggacaagcugga




cgugaaggggaagcgggucgugaugaggguggacuucaacguuccuaugaagaacaacca




gauaacaaacaaccaaaggaucaaggcugcuguuccaagcaucaaauucugcuuggacaa




uggagccaacuccguuguccuuaugagccaccugggccggccugaugguguucccaugcc




ugacaaguacuccuuagagccaguugcugcugaacucaaaucucugcugggcaaggaugu




ucuguucuugaaggauugugugggcccagaagucgagaaugccugugccaacccagcggc




ugggacugucauccugcuggaaaaccuccgcuuucauguagaggaagaagggaagggaaa




agaugcuucugggaacaagguuaaagcugagccggccaaaauugaugcuuuccgagccuc




acuguccaaacuaggagaugucuaugucaaugaugcuuuugggacugcacaccgagccca




uagcuccauggugggugugaaucugccacagaaggcugguggauuuuugaugaagaagga




gcugaacuacuuugccaaggcuuuggagaguccugagcgacccuuccuggcuaucuuggg




aggcgcuaaaguugcagacaagauccagcugaucaauaauaugcuagacaaagucaauga




gaugaucauuggugguggaauggccuuuaccuuccuuaagguccucaacaacauggagau




uggcacaucucuguaugaugaagaaggagccaagauugucaaagaucucauguccaaagc




ugagaaaaauggugugaagauuaccuugccuguugacuuugucacugcugacaaauuuga




ugagaaugccaagacuggccaagcuacuguggccucugguauaccugcuggcuggauggg




cuuggacugugguacugagagcagcaagaaauaugccgaggcugugggucgagcuaagca




gauuguuuggaaugguccuguugggguauuugaaugggaagccuuugccaggggaaccaa




gucacucauggaugagguggugaaagccacuucuagggguugcaucacuaucauaggugg




uggagacacugccacuugcugugccaaauggaacacagaggauaaagucagccaugugag




cacugggggcggugccagucuagagcuccuggaagguaaaguccuuccugggguggaugc




ucucagcaauguuuaguauuuucuuuccugccuuugguuccugugcuccuaagcuaaccu




gcuguuuuccacaucuccauuugguguuagcgcaagauucagcuaguggcugagaugugg




cacagaccuuaacagugcaagcaucucagcucgucuuacugcaucagaugcugguucuuc




aagaucccauuuaaauuccuuagugacuaaaaccauugugcauuguagagggcgucuauu




uauauucugccugagaaaggaagugagcuguaaaggcugagcucucucucugacguaugu




agccucugguuagcuucgucacucacuguucuugacucagcauggcaaucugaugaaauu




cccagcuguaagucugcagaaauuuccgaauuc


 


43
AI047508
uuuuuuuuuuuuuuuucauguuuaauaguuuauuucuuauuuuguugcuuauaucuuc




aauaaaucauuuugcagguuuuguuacagauuuuugauaagccaacucaaguacugauuu




uucauccucucugaaaguuuuaaaccaggaaaggaaaacguuccauggaauccaucuucca




cauggugaugagucacaugaacuccaacauucugaagccgcuugacauacaugaguccauc




aucucuuaggacaucauacuggcaagugaugauauaggucuuagguaaaugaugcaauau




auugucauuggccaacagagggcaugccuucacaucuaugaacccuggauacuuuugagc




cagcucagaacuaccaggagugggauuuuuguaaacgggacuuuucuuguaucucucagg




gagcaaggaacuccaauucacaaacuguaacaaguggcuagauuccauggguacauguug




guuga


 


44
AJ001418
Sequence below.







gagcacccgggacccugggaccacaacgcacuugcucccucucgaccgcgcuccugacccgcagcccucgccaacccuacgga


 


uccuaaccaccgccagccuaggugggcgucaggaugaaggcagcccgcuucgugaugcgcagcgccagcucgcugagcagcg


 


ccagccugguccccagggaggucgagcuguucucccgcuacagcccguccccgcuguccaugaagcagcugcuggacuuugg


 


uucagaaaaugccugugaaagaacguccuuugcuuuucugcggcaagagcugcccguccgccuggccaauauccugaaggag


 


auugacauccugccugaccgcuuagugaacacuccuucggugcagcuggugaagagcugguauauccagagccugauggau


 


uugguggaguuccaugagaagagcccagaagaccagaaagcccugucagaguuuguagacacgcuggucaaaguucgaaaca


 


gacaucauaauguggucccuacaauggcucaaggcauccuggaguauaaagacaccugcacaguggaccccguuaccaaucaa


 


aaucuucaguauuuuuuagaccgguuuuacaugaaccgcauuucuacucggaugcucaugaaucagcacauccucauauuca


 


gugacucaaagacgggaaacccaagccacauuggaaguaucgacccaaacugugaugugguagcaguaguccaagaugccuu


 


ugagugugcaaagaugcucugcgaccaguauuaucuaacaucgccagaauuaaaccucacacaagucaauggaaaauuucca


 


ggccaaccaauccacauuguguacguuccuucacaccuucaccacaugcucuucgaacucuucaagaaugccaugagggccac


 


ggucgagcaucaagaaaaccguccuuccuugaccccaguagaggccacugucgucuugggaaaagaagaccuuacaaucaag


 


auuucugaccgaggaggcgguguuccucugaggauuacugaccgccucuuuaguuacacguacuccacugcuccaacaccug


 


ugauggacaauucccggaaugccccuuuggcugguuuugguuauggcuugccaauuucucgucucuacgccaaguauuuuc


 


aaggagaucugaaucucuacucuaugucagguuaugggacagacgcuaucaucuacuuaaaggcuuuaucuucugagucug


 


uagaaaagcucccagucuuuaacaagucagccuucaaacauuaucagaugagcuccgaagcugaugacugguguaucccaag


 


cagggaaccgaagaaccuggcgaaggagaagcuggcagugugaagcggaugacgccugacauuuuacgggaucaaagugggu


 


cuguggcauugcugcuucgugaauguguguggacucuaguuuccgcaaaacaacgcaacacaaaaccaagcaagcaaaacaca


 


aacacgaguacaaaccuugaccugaugagggacagagcuugguuggaugacccgggagaagucagggcagggcuccagggga


 


uaacagguguccugcuucuccuuuggcaaugcaaaaugacuccugacuguuccaaauacugaaaagaagucugccucugagu


 


uacagcucuuucucaacaaguacagaguuugaggcuugcaguugcaacagcuggauguuuggugguucuugcugccagcca


 


aauaaauugguguuuagugaacauuuucaguguuuccccgccaugcaaagcuuggcgccuugggagaaauguguguaaaug


 


uacauuguauagguauuagugugcucuagaaaggacaggauggaaggaaucaaagcacuuuaucgagcuuguggcugagca


 


uugcagccuaugugcaaacccagaggaaaaguaucucugucaagacagcuccaguaucaugcagcuuuuuauguuugcacuc


 


aaaaagccagugccuucuggcuggugccgaggcuugggugaaauguuaaauaugcacugaccucagaaagucgaguucaaaa


 


gggagauaaaauugccaaagugauccaaggauugugcauguugggaaacccauaugagagaaaggauucucauacuuagaac


 


uuuccuaugaagaaauggugguaaacuuucucuaccuagaaguaguggaaauuucaaggucaucuuaaaaaagaugugcgu


 


uguauauuuuaacuacauucucuacacucuaacauuaacauaucuauucaaauuugucuaguugccaauugucuucagagu


 


gugaaaauuuaaauccuucuugaaguaucuuucgugagaguaguauggaaguaaaacguucucauaucaggaggaugucau


 


uugugaagcauggggacaucaugaacuagugaugugcgugaggcuugggaggcugaaggguaaggaucagcgggaggccau


 


ccauguaggagagagaauuaaaacgaggagcgagggaagcaauggagagagggaagcaagaaaggaaccagaaggcuggcau


 


cauccuauuucccacaggcuaacccaagggaugcucugugccuuuccuggggagggaagggggugaacugguagauuugaa


 


agcaguauggcuucuucugugggucucccucuuacuagacaaggugaaaugauaauucgugucaaauuaaugugaaauuuu


 


uuuccugcauuguaauauuaugaggccugagucgcaguugaguuugaaauuuguauuuaauuucacagugaccuagagcua


 


aggugcucccgguuguggcaauaggagccacaaguauuuucuuucuuucuuucguucuuucuuucuuucuuucuuucuuu


 


cuuucuuucuuucuuucuuuccuuccuuccuuccuuccuuccuuccuuccuuccuuccuuccuucuuccuuuccuuuucu


 


uuucucuucucuucuuuucuuuuuucuguuucuuuuucuuuuuuugcauuguagauguuguccuuaaaagaucagggca


 


gugacuuucacagcaggacuuugacucccacauugguugaucacacaaaacugucagcauuuggguaaucugauguauagu


 


uguuuuguugcugauguuuccauugaaauuucagcucugaguuugugcacaugaauacuuacuuguguuuaccaaagguc


 


uaaggcauuugguuacuuaacccaaauauccugaacugugcguaaaguaauagagaaaagcuuuagggucucaauaguguca


 


ccuguguaaaucaaaucaaaauagccuucccuauuauuuaugaacccaugggagacuuuaaacucuuguagauagaugcuaa


 


augcccaggcccacuuaacuuauuaaugugugaauuacauuuauguuuuuaguuuauaugcaaagaauugugauaauuuua


 


uaauaaauauuuuuauuauaauagu


 









45
AI838080
uuuucuuuuuuuuuuuucuucucuuuuuucugccaccaacagcacugugcaguuuauua




accauucauguacaguagccaucuggggagauugggacagaauugggaucgcaaagugga




uagauauucagcaucuaauggguuggcagaagccgccauauacucuucacaaauaucuucc




acagucaauacagaacuagccauuaucccagcacaccgauuugugc


 


46
AF072127
agccaggagccucgccccgcagcugcacagagagcaaggguauaggcacuaacuuguuug




cagagaccccaucaccuucgggagcucaggugcgcaccuugcaaacuccacuuucugcau




cugccacugagcccgcgggagccucggaaagagccauggccaacgcggggcugcagcugc




uggguuucauccuggcuucucugggauggaucggcuccaucgucagcacugcccugcccc




aguggaagauuuacuccuaugcuggggacaacaucgugaccgcucaggccaucuacgagg




gacuguggauguccugcguuucgcaaagcaccgggcagauacagugcaaagucuucgacu




ccuugcugaaucugaacaguacuuugcaggcaacccgagccuugaugguaauuggcaucc




ugcuggggcugaucgcaaucuuuguguccaccauuggcaugaagugcaugaggugccugg




aagaugaugaggugcagaagauguggauggcugucauugggggcauaauauuuuuaauuu




caggucuggcgacauuaguggccacagcaugguauggaaacagaauuguucaagaauucu




augaccccuugacccccaucaaugccagguaugaauuuggccaggcccucuuuacuggcu




gggccgcugccucccucugccuucugggagguguccuacuuuccugcuccuguccccgga




aaacaaccucuuacccaacaccacggccuuaucccaagccaacaccuucuagugggaaag




acuaugugugacagaggcaaaggaagagaucuuccuggagcaaauacaaaauggacauug




aaccuaggauugacauuaacgccuuagacuguugaugaugguuaucggaacugugguaga




acagaaggaagcauauuuuuauacauccccauggcuaugcaggccuuggcug


 


47
X80417
Sequence below.







cggcacgagcggccacugaccgagaagugcccccgccuggagucagccugggggcaggccaggguccaccagacccc


 


gggaugaccgcagccagucgggccaaccccuacagcaucguaucaucagaggaggacgggcugcaccugguuaccau


 


gucaggcgccaacgguuuuggcaauggcaaggugcauacacggcgccggugccgcaaccgcuucgucaagaagaacg


 


gucagugcaacauugaauucgccaacauggacgagaagucacaacgcuaccuggcugacauguuuaccacgugugug


 


gacauccgcuggcgcuacaugcugcucaucuucucucuggccuuucuugccuccugguuguuguuuggcaucaucu


 


ucugggucauugcugucgcccacggggaccuggagccagccgagggccguggccguacacccugugugcugcaggu


 


ccacggcuucauggcagccuuucucuucuccauugagacacagaccaccauuggcuacgggcuacgcugugugacug


 


aagagugcccgguggcugucuucauggugguggcgcaguccauugugggcugcaucauugacuccuuaaugaaugg


 


ugccaucauggccaagauggcacggcccaagaagcgcgcacagacucugcuuuucagccauaaugccgugguggcuc


 


ugcgugacggcaagcucugccucauguggcgcgugggcaaccugcguaagagucacaucguggaggcccaugugcg


 


ggcccagcucaucaagcccagggucacagaggagggugaguacaucccacuggaccagauugacaucgaugucggcu


 


uugacaagggccuagaccguaucuuccugguaucacccaucaccaucuugcacgagauugaugaggccagcccacug


 


uuuggcauuagccgucaggaccuugagacagacgacuuugagauuguggucauccuggagggcaugguagaggcca


 


cagccaugaccacacaggcucgcaguuccuaccuggcuaacgagauccuguggggccaccgcuuugagccagugcuc


 


uucgaagagaagaaccaguacaagauugacuauucacacuuccacaagaccuacgaggugccaucuacaccccgcugc


 


agcgccaaggaccugguggagaacaaguuccuccugcccagcgccaacucuuucugcuaugagaacgagcuggccuu


 


ccugaucagagaugaggaggacgaggugucuaccgaccgggauguccgcaccccucagcccgagcaugacuuugaca


 


gacugcaggccagcagcgcugcccuugugcggcccuacagacgggagucggagauuugaaugcccuuggcuuagaug


 


cagcaccacccugaccacaauaggucccaugucccuugggggccugcguuugagcagagcaggccgaaagccucggg


 


ucacagacucaguagcaucuuagucuuuuucauguuuuuucgcaguagcuugggaaaguuggcgggagcguggaug


 


gcccaaaugacuggcucacggccucggaggcugauguauacccaugggcaaggaggugacuucuugggguaggguu


 


gcucaggaguuagggacucugcuggaggccuuaggugcaggucccaaccccggugggaggaggcuguguauguaca


 


cuucauugguuuuuaacuugggcaagacuguuuacaaaccaaaacaaacaaacaaacaauc


 


caaaaaaaaaaaaaaaaaaaaaaaaaaaa


 









48
AI847051
uuuuuuuuuuuuuuguuccuuuuuuggaauucccaaagcugguuuuaauuucaaaaaau




uaugaggucucuucccacacuggggauaaugggaugggauagcccaaacuauuaucccagu




ucaaccccagccugguccaaacaccauuacugucacugggcccugucauuucacc


 


49
U09504
uccucguccucgucuguuccaucuucuccaaauagcucuaacugugaugccaacggcaau




cccaagaacgcugauaucucuagcaucgaugguguucugaagagugaccgcacagauugu




ccugugaaaacaggcaaaaccagugcuccuggcaugacuaagagucacaguggaaugaca




aaauuuaguggcaugguucuacuguguaaagucuguggggauguggcaucaggauuccac




uauggaguucaugcuugugaaggcuguaaggguuucuuucggaggagcauucagcaaaac




auccaguauaagaagugccugaagaaugagaacuguuccaucaugaggaugaacaggaac




cggugccagcagugccgcuuuaagaagugucugucuguggggaugucacgagaugcuguu




cgauuuggccgaauuccuaagcgugaaaaacagagaaugcuaauugaaaugcaaagugca




augaagaccaugaugaacacccaguucaguggccaccugcagaaugacaccuuagcagaa




cagcaugaucagucagcacuaccagcucaggaacagcugcggcccaagucccagcuggag




caagaaaacaucaaaaacacuccuucugauuuugcaaaggaggaagugauugguauggug




accagagcccacaaggauaccuuucuguauaaucaggaacaucgagaaaacucaucugag




agcaugccaccucagagaggagaacggauucccaggaacauggagcaauauaauuuaaau




caagaccaucguggcagugggauucacaaccacuuccccuguagugagaggcagcaacau




cucaguggacaguacaaagggaggaacauaaugcauuacccaaacggccaugccguuugu




auugcaaauggacacuguaugaacuucuccagugcuuauacucaaagagucugugauaga




auuccaguagguggauguucucagacugagaacagaaauaguuaccugugcaacacugga




gggaggaugcaucugguguguccuaugagcaagucuccauauguggacccucagaagucu




ggacaugaaaucugggaagaauuuucaaugaguuuuaccccagcaguaaaagagguggug




gaauuugcaaagaggauuccuggcuuccgagaucugucucagcaugaucaggucaaucug




uuaaaagcugggacuuuugagguuuuaaugguacgauuugcuucauuauuugaugcaaag




gaacggaccgucaccuuucuaagugguaagaaguacaguguggaugaccugcacucaaug




ggagcaggggaucugcucagcucuauguuugaguucagugagaagcugaaugcccuccag




cucagugaugaggaaaugagcuuguucacagcaguuguucugguaucugcagaucgaucu




ggaauugaaaaugucaacucaguggaggcuuugcaggaaacacucauccgugcacuaagg




accuuaauaaugaaaaaccauccaaaugaggccuccauuuuuacaaaauuacuucuaaag




uugccagaucuucgaucuuuaaacaacaugcacucugaggaacucuuggccuuuaaaguu




cauccuuaa


 


50
U22033
auggcguuacuggaucugugcggugccgcucgggggcagcggcccgagugggcugcccug




gaugcgggaagcgggggucgcucggacccgggacacuacaguuucuccgcgcaagcuccg




gagcucgcacuuccccggggaaugcagcccaccgcauuccugagguccuuugguggugac




caggaaaggaauguucaaauugagauggcccacggcacaaccacacucgccuucaaguuc




cagcauggcgucaucguggcuguggacuccagggccacugcagggaguuacauuagcucc




uuaaggaugaacaaagugaucgagauuaacccuuaccugcuuggcaccaugucugguugu




gcagccgacugccaguacugggagaggcuguuggccaaggagugcagguuguauuaucuu




cggaauggggaacgcaucuccgugucugcagcauccaagcugcuuuccaacaugaugcug




caguaccgggggaugggccucuccaugggcagcaugaucuguggcugggacaagaaggga




ccaggacuuuacuacguagaugacaaugggacucggcucucgggacagauguuuuccacu




ggcagcgggaacaccuaugccuacggggugauggacagugguuaccggcaggaccucagu




ccugaagaggccuacgaccuuggccgcagagcuauugcuuaugcuacccacagagacaac




uauucuggaggagucgucaacauguaccacaugaaggaagacgguugggugaaaguggag




aguuccgaugucagugaccugcuguacaaguaccgagaggccgcucuguga


 


51
AF033034
Sequence below.







auuccaggaguuccagcugcuggagaggacuguguagaagguaaccuaccccaucucucuuacuucgucucuagaugggag


 


cagacaaguacauauagccugcuuggagcgaggacuuugaaaggcugagacuugcguccacucugagggcaacuaguccaga


 


cucugacaggucagcauuuccugacugggugcacugaaugccaagcaccagaggucugucaccuuccgacauuggaccaaga


 


gagucccagagacccucaaagacacaggaacagagguguccuuugggugagagaccugugcccugccaagccucucagcccc


 


uagaaaggcggcagggcugaguagcugagugugugcaacuugggagcagccugauuucagugcuugucaccugugagggca


 


aaggcagcaugcuuaaugccaucaguccuacucuucucacccguggaacagacgcauaacugaccuuuuuucgugaccacua


 


uuagggugcauuuaaaaaucaaucucucucuuuucugcuccucuuucuccaccuucccucaugugugugucugugugugu


 


guguuucugugugugugugcgugcaccauacagguauaugugccaugacaugugugcaggucaguagacagccuugguug


 


ucagucccugccuucuacuuuguucaaggcagggucuauucuuuauuauugacugcuauccagguacaccaagacaguugg


 


ccugugagguuccagggagucuccugucucuggcccccaucuuauagcaggaguugugagauuucagaaaugugcacccac


 


aucuagcuuuauuuggcaucuuggcacccaaacuuggguucucaugcuuuccaagcaaggacuucacccacugaaccaucuc


 


accagcuccacuauggcgguuuucugaaacugaagggaguggggagaaggcgcugagugugaacgggucuggaaggcgggu


 


auaaccuuuaaggcuggcugguucugagagaggaaagccggcuugugucccauucaggugccaggugcagcaucaaaugug


 


gcuccacccaacggucaguaacuccgcagacagcaccgugguuaacugccucacagagggggcccagggaccuaguuccuua


 


aagcccacuuaguuuugagagacgacauggaggggcaagcccagcccuguccagcugcauucacacgaggcccuucuccucc


 


gaggacccuaccuuuguguuuaguggcugaggcuguguggcucugcuugaagcucuggcuaucaggaaggaccuggcccac


 


cggcuggcaggacaaacuggcccagugaaggcacuguccggucuccugguggaucacaaggaaaggggcguggcauguccag


 


auuugaacccuggaugccucuucccaggguaggaagucuaagggucaacaugaauaggugaggguggugguggaaagaauc


 


ugcaugcaaaaucaggcacucaugucugacaucgucaaacacuauauuuauguagauuuauaugggggugaggcuugggga


 


gcacuuguauuuuugugugcaauugcaagagcuuccuccacauugcaguguuaaauaucauauggugcuggaccaaccauc


 


ucuggaacgagggugaggguuugguacccgugacuaugguucucuguguaguagaaacggcuucuugggaagagagagga


 


agugcuuugaaaugcauccucucuuguuucauucugcaucauggccagguuucucugcacaaagaugcaauagacauucag


 


gaaaauaagcgcauugcaagaugucaaaagucaugaaaaaugaaaagcaaggucacugcagcugggguguaguguggcugua


 


gaagcacguuuaugauguacagguuccgggagagggaggaagagagagggagggaaggaggaauggaggaagagagggaga


 


gggagcaagagaggggggagggagggaggggagaagggagagagagagagaagaaagagagggagggaagaaggaauggag


 


gaagagagagaaagaggggaagaaagagagggagggaaggagggguggaggaagagagaggugugagggauggagggacag


 


agagggagggaaggagaaauggaggaagagagaaacagagagauggaggaagagagaaaagucaccaauuauuuuucucccc


 


agucgcccccugcccucacaccaaggguacccccacuuuucuuucacucaugcacacacacuacacccaauguuuagguaaca


 


cauguagggcaggcagagccuuugugaaugugcuugguaguuuucugccuuacuucuaaauaaccaaucacacggaugcca


 


caggguuccuuuagacuguccagggcuccggggcucuuagacuguucccaaugugggugucacaugcaaacaguaagcacc


 


uucuuguuuguggugcccaggaugcugcagguacuagaaauuccugcacagaccuuugcuacuucuacacagacuuacccu


 


uuaaaacauuuaauuauauguuuuuuucagcauaaagaucuauuuugauuauuuuuaguugcguguaugggugugugccu


 


gugugugauuguguaauugucuguaugggaguguaagugccuacagaggcaucggauccccuggagcugccguuacaagua


 


agggacugggacucagaccugagugguuuggaugagcagugaaugagcguggugagccaucccaccaugcccuauaaacacu


 


uucaagaggacuuugcuggguauggucaaguugucccccugcgacagccaccccaacuugccauccucauuuacuguacugg


 


aagcagcaaccaccucugcaauuuugcacaagaaccugagagucugaaagacuuuuguuggcacuggccuguguuccacugg


 


gguggacacauuaaucuaaaagcuaagaagcucacuucagcuuugccaggcaaccagcacguuugagcacaacgguguagcc


 


aggaagggugugugggaauuuugaugcuaguuuuucuuuaauuagguugagagugaaaucauggucuguaugcauccaac


 


aacuuaauccaaaaaguugguugcacggcuccuggaagguuuaccggcaaggaaccugucccauuuuguaaguagguggga


 


cuggagaguugccaagaagccccccucccugcccccuuccuccuggcagauucugcuuaaaaugagugugguucacugcaga


 


auagugucaccugucuucagaugucuaaagacauaagaaaggccuagccagcuaagucagaaaaggggacuuuccgguggga


 


augcauuuuccagucucuaggagaagucuuuauccaaauaaaauuagcauagugguggagucacugccagggcgcuggugc


 


ggaagcacagcccagagccgaggacguggccauccuccuuccucugaugcaaaguguucucuauccccaguuaccaugagca


 


auaucaguagcaucgugaaccgggcccgugaugccuuuaacucaggcaagacucgaccgcugcaguuccggguugagcagcu


 


ggaggcguugcagcgcaugauc


 









52
AA960603
uuuuuuuuuccaaaaaauuuuauugggggaaacuacaaaacauuuacaguacaauguuua




cagucacaauuuguagugaacugauuccccaaaauauauuacaacucaaguugacuuaau




cuuguuacauucaaaaaccuacuucugucaaaguaguccagagugcacacgcggugcucc




aacuguaccuacauacaaacuaaacaacugcucauuuaucugccauccaggaaagccgga




gacauuccugccucuuuacauugaaaaauaauaguacaaguuuuuggacugucauugaac




aaggcauauucauguaccaccaacauuuc


 


53
U47737
Sequence below.







ggugauccuccaggaccuaagguuucgguauuaucuucggggccucuucacccggaggugagucugcugagcccgaccuca


 


gguguucacucgucacgcgagggccuggccacggcggggaagcacugggagagagcgggaggccuugaccgcagcguguag


 


gaucuggggucccggcgcucugcucccgggugcagagugguuggagcaugcgaggcccucugcagcgugcucuguuccuac


 


caucaccccacccccaccccaguccuuccugcacguuucuggagaggcaaaggccccugcugagccuucacuggguaccccua


 


ucucgacuccacuugucugcuugggaucuccaaagggggauacacccucguaaacuagagcaggaggcugggggguggggg


 


uagggguagggucugaccaguuagauugaggcuggacccuccccagagugaggagcgggaagcucuuugucuuauccagga


 


uuuugcauaucaaugcugagguucuggugauuaaguagggucccuggcuagcggggguaaccugaacaaccuuccuccgcu


 


ggccgcuagccaauagacaccuggcuuccgcggaugagcccuuugaguuuguggagguguuccucagguccccagggcccu


 


gccccguugccugcagauguguggacagacaaaacauuggacucguuuuccaaccacuucaccccuuccuucgcuaguccuc


 


cgguggacgaugggaugccucauugacuuguuuguggcugugcaugccagagcuuccuagcagacagcucagggcuccauc


 


guuccuaaaucccacuguguaacgaaaaaaaaaaaaacaaaaacaacaacaacaacaacaacaaaaacaaaaccagaaaugagga


 


caggcccagcugggcuuggcacugaacuuggccaccuggagcuuuggcuacccacuacaagaugucagcaagucucaggaua


 


gaagaggccuaaggccaguccuggaagauaccaaaacuucaccuccucuauaccccguuccucuaggagaacuguaagccacc


 


uuugucucugggacgccccucucccacucaacagauggcaccagucaucuuccuccucaagaggccagugguauucaaaaua


 


ggauauugaaaccaagcaagcugguccucuccucuacccuaugccaaagacuucugcccaaagggcccagaaaagucccauag


 


ccaucuggcuggcuagugugcugacugcuacaggugucaguguccccagcgagcagguaguggaguggaggugucuucuu


 


guggaaauggguccugagccucuaccuuguacagaaaggaauuagugaagcccagaggccuccagcccgugucucugccaca


 


agagagaggggguggggguggggcuguauuugguucccagggcucagggaagguuuucgguucaugcaugcucauuuauc


 


ugaccacugucuuaaccccaggacaaccacuuaacuguccacuuccauaucagaguucuugguuccccuuuacuucgucuau


 


ggagccccugaguuugggaagggguauuaacugaaagguaccauuagaugaacuuggagaaagauuuguaggugccacggg


 


agauuucagguaaaagcucuuuuaauaauuggcuacaauagcagcaggaggaggccaggaauucugagguagagauuugau


 


uagcagcacguggagcaaaggagacuucugacuccuacagguuucagaaaguggggagaggcucucagaugaauggcuugg


 


acugugagguaaguguuaguguagcacgagacuagcuuaaggcuguacaaauuguccgucugauuggugcauugggccagg


 


uagacacuagauaagcaauugggccuuaacucgaguugucuuaauggcuacccccagggcagcagggagucaauacugcucu


 


ccugucuggggccugaaugcugaaaccaucuacaaaggggacauaaggcauauuggggagguguagagugggccaggccca


 


gggucugcugguaucuaugccaggauccugaguggugguggcguagccugucuuuuaaccaacugccucucucacaguagg


 


cuuacuuuggcuugcgaaccuucagcagaugucugccacuuccaacaugagagucuuccugccugugcuguuggcagcccuu


 


cugggcauggagcaagguauggagcucugagauaacccugcagccugguccuccuccugaucucucauucuuucuccugag


 


uagaugcccagggcuccuccugagccagcccuccuaggaacgucuggccuucccaccuccuacucucuagccaacugaccua


 


guuccccugaugcugugcuggcccagcuacaccuuugucaccucguguugacuuuagccacuccaguaccaaagucugaagu


 


caguugucauuggcuggcuuuuuucccugacccagggcugagcaugcuguugcuucuugucaguggguuggggaucaagg


 


gccccacuggaaagucaccuuacccuggaaggcuuccccaggcaauaggcaggugucaccuacagcauugucccuuuugcag


 


uucauucccugaugugcuucucauguaccgaucagaagaacaauauaaacugccuguggccaguuucaugccaggagaaaga


 


ccauuacuguaucacguuaucugccgcugcgggcuuuggugaguagcugccuguuucccuagccagggccagggaccugcg


 


gggcuuuccccauuuccugcucccugucugucuguccccucauccucacuuuccaugcagggaugucaaccuuggcuaca


 


cccugaacaagggcugcuccccgaucugccccagugaaaaugucaaucucaaucucgguguggcguccgugaacagcuacug


 


cugccaaagcuccuucugcaacuucagcgcagcuggccucggacuucgugccaguaucccacuacugggccuuggacuccug


 


cuuagcuuguuggcucugcugcagcugagccccugaccaucccccauguguucuccauauccccccagcucaggaaaagccc


 


agcuccuuuuaggucccaggggacccuaggaaccuucagcuccuccugggugugucuaguucccccuccacacucucucaac


 


gucagggcuaaguaccaaacucacccauaccugcucuguugaagugguacuggcuacccuugcuuccagagccaauccuaua


 


accucccuuggggaaccagcgaaggggugaagaucuccuuggagucucaagaguaccagagucagcgccgaaucuuguggac


 


acacugacaaggaugucuaauccaaauagauguauaucugugugcucaguguaucccugugugaaugaagccacuuggauu


 


cuggggugggcaaagaagaccugaaaagauucuacagcagaaggccugugucgccaccaaaaccccucccccugguaucauu


 


guacccaccuuguacucuguucaggaggcugcccauggaggacugccaccccuccagaugaaggcucccacuacccgaugca


 


guugagucccauccugcccucucugcccacacuggcuuccugcugcuauucuagugccucaaauaaaccguucacacccuu


 









54
L00039
cuuccucccucuacagaagaagagcaagaagaugaggaagaaauugauguggugucugug




gagaagaggcaaaccccugccaagaggucggagucgggcucaucuccauuccgaggccac




agcaagccuccgcacagcccacugguccucaagaggugccacgucuccacucaccagcac




aacuacgccgcaccccccuccacaaggaaggacuauccagcugccaagagggccaaguug




gacaguggcaggguccugaagcagaucagcaacaaccgcaagugcuccagccccaggucc




ucagacacggaggaaaacgacaagaggcggacacacaacgucuuggaacgucagaggagg




aacgagcugaagcgcagcuuuuuugcccugcgugaccagaucccugaauuggaaaacaac




gaaaaggcccccaagguagugauccucaaaaaagccaccgccuacauccuguccauucaa




gcagacgagcacaagcucaccucugaaaaggacuuauugaggaaacgacgagaacaguug




aaacacaaacucgaacagcuucgaaacucuggugcauaaacugaccuaacucgaggagga




gcuggaaucucucgugagagcuaaggagaacgguuccuucugacagaacugaugcgcugg




aauuaaaaugcaugccaaagccuaaccucacaaccuuggcuggggcuuugggacuguaag




cuucagccauaauuuuaacugcucaacuaaauaguauaaaagaacuuuuuuuuaugcuuc




ccacucuuuuuucuuuuuccuuuuaacagauuuguauuuaauuguuuuuuuaaaaaaucg




uuaaaaucuauccaauuuuccauguaaauagggccuugaaauguaaacaacuuuaauaaa




acguuuauaacaguuacaaaagauuuuaagacauguaccauaauuuuuuuu


 


55
D21099
gugggacgggccccccucgaggucgacccacgcguccgggaguacccccgaccuuggcug




cgugcugacucgcuuccuucugccugcccaggcuugcacuccccggggaucugccucugc




aucucuugccuucgcuguuguuucccucucuguccagcuccccucccgcucucgcccugg




agaauggcucagaaggagaacgccuacccguggcccuacggcucaaagacgucucagucu




ggccugaacacguugucccagagaguccuacggaaggagccugccacgacaucugcgcuu




gcucucgugaacugguccaacagccaguccacagcugccccuggccagaaguuggcugag




aacaagagucagggcuccacugccucgcaaggaucccagaacaagcagccuuucacuauu




gacaacuuugagauugggcguccuuugggcaaaggcaaauuuggaaacguguacuuggcu




cgggagaagaagagccguuucaucguggcacucaagauccucuucaagucucagauugag




aaggaggggguagagcaccagcuucgccgagagaucgaaauccaggcgcaccugaaacau




cccaacauccuucaacucuacaacuacuucuacgaccagcagaggaucuacuuaauccug




gaauacgccccucgcggggaacucuacaaggaacugcagaagagucggaccuucgaugag




cagcggacugccacgaucauggaggaacugucagaugcccugaccuacugccacaagaag




aagguaauucacagagacauaaagccggagaaccugcuguuaggucugcagggagaacug




aagauugcagacuuuggcuggucggugcaugccccaucccugaggaggaagaccaugugc




ggcacgcuggacuaucugcccccagagaugauugaggggcgcaugcauaaugaaauggua




gaucuauggugcaucggggugcucugcuaugaacugaugguggggaacccccccuucgag




agcccuagccacagugagacguaucgucggauugucaagguggaccugaaguuccccucu




ucugugccuucgggcgcccaggaccucaucuccaagcugcucaaacauaaccccuggcaa




cggcugccccuggcggagguugcagcucacccuuggguccgggccaacucaaggaggguu




cugccucccucugcccuuuagccugcuccuugguuuuuugucccugucauuuuucagugu




ucuuuguaugucuguguauguguucugagaaggggugggaacuggaaacuauuccuagc




uccaguucuaggggaucugaucucucuucugaccucuacaggcaaaauuaggcaccccugu




ggugcacauauaugcacgccaaacacaugaaguuacaaacaaacaacaaacacacagaua




gugcuggagagauggcucggcaguuaaaagcacuggcugcucuucccaggaaccuagaac




ucaauucuagcacuacauggugcucacggccacugucuguaacacccaguccuggggaau




cuggggccuucgagccucugcaggcacuaggcauggaugugguauacauguaugcaggca




aaacacccaugcacugacuuuuaagaaacccucuagucugauuccuuucaauuugucaaa




uguugaauguuauuuuuaaaauauuauaagccauuuaauacaauuuuucuuugaaacaug




guauagccuagucugucuuaaauucagaaaaauuaugaagaacaacauuuuauaauaaag




ucuuaaauguuucauguuuuug


 


56
AF026481
Sequence below.







uugccuaggaagggcgcgucgucucucugcucguccggcugugacggggaagggucccgcugcguuuuggucacugugag


 


uaccaaguuugggggauccccgagggacucucgagagcucauuuuagggaugcaggggcuacuccccggugguagagagcu


 


uucuaguuggcaggagguuucguauguggaggaggccagcuuaggcagaaagcacauguucucagagaugaggacaagacu


 


aagaccgucuaaucccugaucuuuaccuuccggcccgcugaccugggccuggaugcuaaagcccucugcuuucgucuaaaca


 


gcgcuaaauaguaaacaguauugccuaagauaaaugcggauuauuacccgauucagugucgggaaaaggcagcuaggagaga


 


gcggcuggcacgugguaagcacacgguaaguuucgguuaaauuaaaacaaccauccguugagcaucucuuagcaagcuccuu


 


ccacccuucaaacaaucagugauagugcgucuguuucacugauuagggagcuaaggcuccaacagcagcaaaggaacuaauc


 


cgccucugaucaacauggcguuucuuacagggcauuccuuauacgcuuucccacgugcguaacaggaaucggguguucccg


 


gguuuuguuuuguuguuguuguuuuuguuuuguuuucuuagugaaagaggcagggugggcuccaggccgcugaggauua


 


auaaagagauucuaugaggaggaaauaacaggcaggugguaugaucgaggcaaggcccugaggaaggcuugggugggguga


 


guagaaccagagccggaaguccacucagcagccuggggcacuuaaagcuucugcuggggcaaaugguaaggcggcguaaggu


 


cacauuccuuucauuucuuccagacucaggaggagaccacaccuuccggagaaccaggccugaaccgagguacuauuuugua


 


gcucucagaagccaggacucugcaacacuguuugcugccuguggaucuucuauauucacagugucccaguugcuucugauc


 


uaccacuguuagauacuucugccacccauccuaagaguauaguuguucuuggaaaggagucucagcugcugucagcaggag


 


ucccucauucgacuccugugguugcccuuuccaccaugccaaagaauaaaggcaaaggaggcaaaaacaggcgcagagguaaa


 


aaugaaaaugaaucugagaaaagagaguugguguuuaaagaggaugggcaggaguaugcucaggugaucaaaaugcuggga


 


aauggacgguuggaagcaaugugcuuugacggugugaggaggcuggccauauaagagggaagcugagaaagaagguuugg


 


auaaauaccucggacauuauauugauuggucuacgagacuaucaagauaacaaagcugauguaaucuuaaaguauaaugcag


 


augaagcaagaagucugaaggccuauggagaacuuccagaacaugccaaaaucaaugaaacggacacauuugguccugggga


 


ugaugaugaaauccaauuugaugauauuggagaugaugaugaagacauugaugacaucuagccugaccuaagcaugcuacc


 


uuccaaguucucugaagauagcuccacacaguggcaucuugaccuucaucuguuaaguaaaacuucauggcauguguaugac


 


uuguuaaugcaagcuaaugaauuuuauuuuuugaaguacuauauuucuuugaaaaccaaagauguugaguuaucaucuuaa


 


gugacauguuaacacuuugugcuuuugaauauaauugaaccuagcgcacagcagugagcacuguuaagagacugccuuucc


 


auuuguagcuucauuucuggcacgggaguguuuugugucagcaguucugccagguggccaucgaugagcugaaguaaguc


 


cuaguccagcacaucugcuucaggccuuuguacucuagucaucuggcugcguucgagacuucucagcagaacuuauagaug


 


uguacggcugcacuuggagucagacaagauauggcuacuuuuguacuuauggagccaugccauuuuauacuuucacguugu


 


auacauucguuugacccuuuaaguuguugccacccauaaaaaggcaucuuacagugcaguuuuuaaauuacauggguagca


 


auuuugaguuuuaaaaauuagucauugcagaaauuaaauacuuagaggagauaauccauuaucuugauuuuaggaauauaa


 


uaguugacaauguuuauauauaauuuuacuucucuaaggcauacccaaaaauagaaaaugaaaaagagcagugagucuguuc


 


ugaugcuugcauugcauagagaaguuuuccaacaaagcagcuguuaauaacacauaaaauauguuuuacuuugcaaaguagg


 


uuguguuaagucauuuucaaaaaguuaccuacuauaucgaggcucuggauaauuacuauguguugauuaaaguuaguuaca


 


gaauuguacaagcuaagauuuuccuuaaacuaagcuuagguuaaagggagaggagccacagcucaaugaaaacacgguuccug


 


uuuucuaaauggaggcgcccagaaacacaauaaaacauguugguacaaaaaaaaaaaaaaa


 









57
J04596
caugaucccagccacccgcucgcuucucugugcagcgcugcugcugcuggccaccagccg




ccuggccacaggggcgccuaucgccaaugagcugcgcugucagugccugcagaccauggc




ugggauucaccucaagaacauccagagcuugaagguguugcccucagggccccacugcac




ccaaaccgaagucauagccacacucaagaauggucgcgaggcuugccuugacccugaagc




ucccuugguucagaaaauuguccaaaagaugcuaaaagguguccccaaguaacggagaaa




gaagacagacugcucugauggcaccgucuggugaacgcuggcuucugacaacacuauaca




auuucuuuugaggguccuauuuauuuauguauuuauuuauuccacaaagugugugguuu




uuauuuuacauuaauauuuaacaguguggauacauuucaucgaugguaguucaguucugc




uuguucaguuuaaagaugguaggcuuaaaauauuucauuaaaacuaauauuuauugggag




accacuaagugucaaccacugugcuaguagaaggguguugugcgaaaagaagugcagagag




auagaguuuaguauuauguuuuguauguauuagggugaggacaugugugggaggcugug




uuuguaugucuugaaaagaaugucaguuauuuauugaaagucgucuuucauauuguaug




gucaacacgcacguguugacgcuucccuuggacauuuugugucuaguugguagcccauaa




ugggcuuuuacauucuuuaacccuguuucuccuggucucgucucgcucgggacagagacg




uucaaaggacuguuacaaaugaaguaaaaauaaaaguuuuauuaag


 


58
X81580
cgucucccgcauucgucugggccgugcaccugcccgcuagcucgcugcacuaccguugcc




cacaagccaacaugcugccgagauugggcggccccgcgcugccgcugcuccugccgucgu




ugcucuugcugcugcucuugggcgcgggcggcugcggccccggggugcgcgccgaggugc




uguuccgcugcccacccugcacgcccgaggcucuggccgcuugcgggcccccacccgacg




cgcccugcgccgagcuggugcgagagcccggcugcggcugcugcuccgugugcgcacggc




aggagggcgaagcaugcggcgucuacaucccgcgcugcgcccagacgcuacgcugcuauc




ccaacccgggcuccgagcugccccugaaggcgcuugucacaggcgcggguaccugugaaa




agagacgcgugggcaccaccccacagcagguugcagacagugaugacgaccacucugagg




gaggccugguggagaaccacguggaugggaccaugaacauguugggaggugguagcagug




cuggccggaagccccucaagucaggcaugaaggagcuggcuguguuccgggagaagguca




augaacagcaccggcagaugggcaagggugccaaacaccucagucuggaggagcccaaga




aguugcgcccgccucccgccaggaccccuugccagcaggaguuggaccagguccuggagc




ggaucuccaccaugcgccuuccggaugaucggggcccccuggaacaucucuacucccugc




acauccccaacugugacaagcauggccgguacaaccuuaagcagugcaagaugucucuga




acggacagcgcggggagugcuggugugugaaccccaauaccgggaagcccauccagggag




cucccaccauccggggagaccccgagugccaucucuucuacaacgagcagcaggagacug




guggggcccaugcccaaagugugcaguaaaccccagccagucggugccuggcuuccccau




cccgaacaccagcagaaauggagggcgucagggugacggguguggaggaguucccaguuu




ugacacauguauuuauauuggaaagagaccaacacugagcucagaagccccccucugacc




ccccccagcggcuguuaacugaaccucccuugcuucuguuagagaggggaagggugguau




ggagggcacuggguacaggccugggaauggggaaagaaauuuuuauuuuugaaucccugu




gucucuuuuacuuaagauuaaaggaaggaaaaauaaaaaaaaaaaaaaaa


 


59
AI314958
gaugugaaaaacguuuuuauuauaaucucuuaaacuuucaguguauauuuucauuacaau




cauugguacaauaaauauggaaaugcugagcagacaauuaucacaguggccuaugggcug




agggacagggacccaggaauacuguuacccuggauacuuccucagggccaaucaggaggu




cuucaaagaguauugagagggagagggauagaaauauuauuaagacugucagugcagcaa




cuuuuagaaugucuauuaaagccauggauacaggauuuacgauaacagaagauggauacu




aaaaaagaacagagacucaaguucuccuguaagaggcagaagaaacauugcagaagccag




ugccuuccucggguccccagugugugcccccauccacccacgcauuguguuggucaucuc




caccugcccugugcccagcccugugcccacccagguucuccuaggcacccaccuugcacc




ucgcacg


 


60
AF058798
gaauucugcgcgguuuugcauuuuuugggucagauuggcuuuuuacaugauuacgaagc




uccaacgacuagaccacagggaccgucgccuuggcggccgagcagucguauccaacuugga




gacagccaguucgccgugugucugucuguccuucaucgcagucauggagagagccagucu




gauccagaaggccaaguuggcugaacaggccgaacgguaugaagacauggcagcuuucau




gaagagcgccguggaaaagggcgaggagcucuccugcgaggagcgaaaccugcuuuccgu




agccuacaagaacguggugggcggccagagagcggccuggaggguccuguccagcaucga




gcagaagagcaacgaggaggggucagaagagaagggccccgaggugaaagaguaccggga




gaagguagagaccgagcucagaggugugugcgacaccguacucggccugcuggacucgca




ccucaucaaaggggcuggagaugcagagagccgcgucuucuaccugaagaugaaggguga




cuacuaccgcuaccuagccgagguggccacuggcgaugacaagaagcgcaucaucgauuc




ugcccggucagccuaccaggaggccauggacaucagcaagaaggagaugccgccuaccaa




ccccauccgccugggccuggcccugaacuuuucagucuuccacuacgagauagccaacag




ccccgaggaggccaucucgcuggccaagaccaccuucgacgaggccauggccgaccugca




cacccucagugaggacuccuacaaggacagcacccucaucaugcagcuccugagagacaa




ccugacgcuguggacagccgacagugcuggggaagaggguggugaggcuccggaugaccc




ccacaucugaagcagcggaaaaacaacccggguuggcuuggccuuccaguccccagccug




gcauagaggauuaaaagggagugggauuuugccuuucccaaacccugaauguucagcaac




accuugggaaggucuuucgaagggggcgcagccaagcugaagccaccagggcagggaauu




uaauuuuucguguagcuguuuggguggguguuucccaaaaccaucccaccccuguuuuuu




gaacccccuccccaauucuucccccugagccucccucgggcaccuguugcuuuuggaucc




gaauaauccaggagguuccccacccuguggcugagaaauggacuguggcaagggcugugu




gugugugagagagagggaaacucugugugugugugugugagagagagagagagagugaa




ugagagggaaaaaguuugcugggugugaccaugguaccaaucaauaaaguugcccuguga




gacucaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa


 


61
AW046627
uuuuuuuuuuuuuuuuuaaauaccaaaacauuuaauugaaauaccuguauaaaaaauaug




aucuucagacauuucacacuuuugaacuuauacaaccccaccccugaugcuuagucacac




cagggucacagaaacacagcugcuaaaauaaauuaagggcuugagacucugucccccaac




cccagcuuucagagccagcaagcagacuguacaaggucaauaauuuaaaccccuccccag




cgcagagugcucagggugacagggucuc


 


62
AI848050
uuuuuuuuuuuuuuuuuaauguaacgaccggugugcuucaguuuguuuagcagaaccac




ucucuugaaucacauuaacuuuugagauuuaaaaaaaacaaaacaaaaaaaaaaaaaaaca




acaaaaaaaaaaccaacccuccauagcacagcugucuuuuaugcaagcaagagcacaccu




acuccagcaugauuugucaucuaaagacuugaaaacaaaacaacaacaacaaaaaguuac




uuauagucaauggauaagcagaguccgaauuuacacuaaucaagacagaccuucgagggg




ucacgauaaguccggaacuuucaaaccuugcuucguaugaauuguacuaucugaacauaa




acugcacuuuuauuuuc


 


63
AF065441
augagacuccacagccucauccugcucuccuuccuucuccuggcuacucaggcguucuca




gaaaaggucagaaagagagccaagaacgcaccacacagcacagcggaggaggggguagag




gguucagcucccucguuagggaaggcccagaauaagcagagaagcaggacaucuaaaucu




cugacgcauggcaaguuugucaccaaagaccaagccacaugcagaugggcugugacugag




gaggagcagggcaucagccugaagguccagugcacacaagccgaucaggaguuuucuugu




guuuuugcuggugacccaacugacugccuuaaacacgacaaagaccagaucuacuggaaa




cagguugcccgcacgcugcgcaaacagaaaaauaucugcaggaacgccaagagugucuug




aagaccagagugugcagaaagagauuuccagagucuaaccucaagcuggugaaccccaac




gcacguggaaacacgaagcccaggaaggagaaagcagaggucuccgcaagggagcacaac




aagguccaagaagcugucuccacggagccaaacagggucaaagaagacaucacacucaau




ccagcugcgacccagaccauggccauuagagauccagagugucuagaggauccagaugug




cucaaccagaggaagaccgcccuggaguucuguggggaaucuuggagcuccauuugcaca




uucuuccucaacauguuacaggcgacaucaugcuaa


 


64
AF022992
Sequence below







cgggucgacccacgcguccgcccacgcguccggcggagcuucuggguugcgggccgaaacggcaagcggauggagggcgcuc


 


gaacggccaggugucgugauuaaauuagucagcccucagagacaggcguccuaccuccuuuauccagaccucaaaagccccg


 


uugugcacccgugguggcuucuucaccuucccuguuucguccuccacuguauggcccagacaugagugguccccuagaagg


 


ggccgaugggggaggagaccccaggcccggagaaccuuuuuguccuggaggagucccauccccuggggccccgcagcaccgg


 


ccuuguccaggccccagccuggcugaugacacugaugcaaacagcaauggcucaaguggcaaugaguccaacggacccgagu


 


ccaggggcgcaucucagcggaguucucauaguuccucuucuggcaauggcaaggacucagcucugcuggagaccacugagag


 


cagcaagaguacaaacucacagagcccauccccacccagcagcuccauugccuacagccuccugagugcgagcucagagcagg


 


acaacccaucuaccaguggcugcagcagugaacagucagcucgagccaggacccagaaagaacucaugacugcacuucgggag


 


cucaaacuucgacugccaccagagcgucggggcaagggccgcucugggaccuuggccacacugcaguacgcucuggccugug


 


ucaagcagguucaggcuaaccaggaauauuaccagcaguggagucuggaggagggugagccuugugccauggacaugucua


 


cuuacacccuggaggaauuggagcauaucacauccgaauacacacuucgaaaccaggacaccuucucuguggcuguguccuu


 


ccugacaggccggauugucuauauuucggagcaggcagguguccugcugcguugcaaacgggauguguuucggggugcccg


 


cuucucagagcuccuggcuccccaggaugugggugucuucuauggcucuacuacaccaucucgacugcccaccuggggcacu


 


ggcaccucugcagguucaggucucaaggacuucacccaggaaaagucugucuucugccgaaucagaggagguccugaccggg


 


auccagggccucgguaccagccauuccgccuaaccccauaugugaccaagauucgggucucagauggagccccugcacagcc


 


gugcugccuacucauugccgagcgcauccacucugguuaugaagcuccccggaucccuccugacaagaggaucuucaccacc


 


cgacacacaccaagcugccucuuccaggauguagaugaaagggcugccccacugcuggguuaccuuccccaggaucuccugg


 


gggcuccaguacuucucuuucuacauccugaggaccgaccccucaugcuggccauucauaagaagauacugcagcuggcagg


 


ccagcccuuugaccauuccccuauucgcuucugugcucggaacggggaauaugucaccauggacaccagcugggccgguuu


 


ugugcaccccuggagccgcaagguggcuuucguguugggucgccauaaagugcgcacggcaccccugaaugaggacgucuu


 


cacucccccagcccccagcccagcuccgucccuggacucugauauccaggagcucucagagcagauccaucgauugcugcugc


 


agccugugcacagcuccagccccacggggcucuguggaguuggcccucugauguccccugguccucuacacagcccuggcuc


 


cuccagugauagcaaugggggggacgcugaggggccugggccuccugcuccagugacuuuccagcagaucuguaaggaugu


 


gcaucugguaaagcaccagggacaacagcucuucauugaaucucgggccaagcccccaccccggccccgccuccuugcuacag


 


guacauucaaagccaaaguccuucccugccaguccccaaaccccgaacuggagguggccccaguuccugaccaagccucguua


 


gccuuggccccugaggagccagagaggaaagaaaccucuggcuguuccuaccagcagaucaacugccuggacagcauccuca


 


gguauuuggagagcugcaacauucccaguacaaccaagcguaaaugugccuccuccuccuccuacacugccucuucagccuc


 


ugaugaugacaagcagagggcagguccaguuccugugggggccaagaaagauccgucgucagcaaugcugucuggggaggg


 


ggcaacuccucggaaggagccaguggugggaggcacccugagcccgcucgcccuggccaauaaggcagagagcguggugucc


 


gucaccagucaguguagcuucagcuccaccaucguccaugugggagacaagaagcccccggagucggacaucaucaugaugg


 


aagaccugccuggccuggccccuggcccagcccccaguccggcccccagccccacaguagccccugacccaaccccagaugcu


 


uaucgcccagugggucugaccaaggccgugcugucccugcacacacagaaggaagagcaagccuuccucaaccgcuucagag


 


aucuuggcaggcuucguggacuugacaccucuucuguggcccccucagccccuggcugccaccauggccccauucccccugg


 


ucgccgacaccacugccgaucuaaagcaaagcguucccgccaccaccaccaccagacccccggcccgaaacucccugcuaugu


 


cucccauccuucaccugugcccucuucuggacccuggccacccccaccagccacgacccccuucccagcaaugguccagcccu


 


acccacucccaguauucuccccucgaggaggaccccagccccuucccccugccccuacaucuguguccccugcuaccuucccu


 


ucucccuuagugaccccaaugguggccuuggugcucccuaacuaucuauucccuaccccaccuaguuauccauauggggugu


 


cccaggccccuguugaggggccacccacgccugcuucccacucgcccucuccaucccugcccccaccaccucucagcccccccc


 


accgcccagacuccccacuguucaacucgagaugcagcuccccacuccagcucaaucugcugcagcuugaggaguccccccgc


 


acggaggggggcgcugcugcaggaggcccaggaagcagugcugggccccugccucccagugaggagacugcugagccagagg


 


ccagauugguggagguuacugagucguccaaucaggaugcacuuucaggcuccagcgaccugcuggagcuacugcuccaaga


 


agacucucgcucgggcacaggcuccgcagccucaggcucccugggcucuggccugggcucugggucugguucaggauccca


 


cgaagggggaagcaccucagccagcaucacccgcagcagucagagcagccauacaagcaaguacuuuggcagcaucgacucuu


 


ccgaggcugaagcuggggcugcucgggccaggacugagccuggggaccaggucauuaagugugugcuccaggaccccaucu


 


ggcugcucauggccaaugccgaccagcgugucaugaugacauaccaggugccguccagggaugcagccucugugcugaagca


 


agaccgggagaggcuccgggccaugcagaaacagcagccacgguucucagaggaccagaggcgggaacugggugcugugcac


 


uccuggguccggaagggccagcugccucgggcccuugaugugauggcguguguggacuguggcagcagcguucaagauccu


 


ggccacucugaugacccgcucuucucagaacuggauggauuggggcuggagcccauggaagaggguggaggcgaggguggu


 


gggugugguguuggcgguggugggggugaugguggugaggaggcccagacccaaauuggggcuaaggguucaagcucuca


 


ggacucugccauggaggaagaagagcaaggugggggcucauccagcccagcuuuaccugcagaagaaaacagcaccagcuag


 


auccauuuuggggccgcuuacagcagucuaaugagaggcuuccuuucgaccauguugggguucuuauaacucaagauacag


 


cuggaccaaccaauaggaaacugccccagcuucucccaacauagggggcuggacccccauuaccagcccaggcacaggagcug


 


ccucuagcuucuuagcagaguggaaguucucagccccauuuggaggauuguccacgcccgucccacugaggagacgggcgg


 


gucuucgguuaagguugcugacaagcugcugaaguggucuguccaaaucccagcugagccugagucccagucgcaggguug


 


gggcugcacuuauuuauuugggagagacagcucacucucccaccucaccccaagaugggaggaggggaaccugggaucugu


 


guaggauccagguccgugaaccccuagcugcuccagggugggggagguugguggaccauggagucccuggugcugccccuc


 


aggugggacccagguguucucagcucuacccucuaccaaugacauuuguguuuuugauauugugucuguuauuuuuuuuu


 


uaauacaaaaugacaaaaugaaaaaccaaaaa


 









65
AF064088
Sequence below.







gacagcggagcgcgguggcgucgacgucuagugucucagugcucccgucuguggcuaacuaagcagccagcagccaggcagc


 


ucgcgaccugcggccaggcagccaaccaugcucaacuucggcgcuucucuccagcaagcuucggaggggaaaauggaacuaa


 


uuucugaaaagcccagagaggggaugcaucccugggacaaagcugagcagagugacuuugaagcgguggaagcgcucauguc


 


caugagcugcgacuggaagucucauuucaagaaauaccuugaaaacaggccugucacaccagugucugauaccuccgaggau


 


gacagcuugcuuccagggacgccugaccuucagacagucccagcauuuuguuuaacgccaccuuacagccccucugacuucg


 


aacccucccaagggucaaaucugacugcaucagcgccaucuacuggccacuucaaaucuuucuccgaugcugccaagccucca


 


ggcgccacuccuuucaaagaggaggaaaagaauccuuuagcugccccuccucuuccuaaggcucaagccaccagugucaucc


 


gucacacagcugaugcccaacugugcaaccaccaguccugccccgugaaagcagcuagcauccucaacuaucaggacaauucu


 


uuccggagaagaacccacggaaauguugaggcuacucgaaagaacauacccugugcugcagugucaccaaacagauccaagcc


 


ugagcccagcacaguguccgauggugaugagaaggcgggcgcugcacuauaugacuuugcugugccuuccucagagacagu


 


aauuuguaggucuagccagcuccuucguccccagugcagaagucaguacuggugucuucaccuacaguauccacuggggg


 


agugccaccccugccugucaucugccagaugguuccccuuccugccaacaacucucuuguuagcacaguuguccccagcacu


 


ccuccuagccagccaccagcugucugcucaccuguguuguucaugggcacucaggugccugagggcaccgucguguuugug


 


guaccccagcccguugugcagagcccaaggccuccaguggugagccccaguggcaccagacugucucccauugccccugcuc


 


cuggauucucuccuucagcagcaagggucacuccucagauugacucguccagaguaagaagucacaucuguagccacccagg


 


guguggcaagacuuacuuuaaaaguucccaucugaaggcccacgugaggacacacacaggggaaaaaccuuucagcugcagc


 


uggaaaggcugugaaaggagguuugcucgcuccgaugaacuguccagacaccggcggacacacacaggugagaagaaguuug


 


ccugucccaugugugaccgucgguuuaugaggagcgaccauuuaaccaagcaugcccgacgccaccuaucagccaagaagcu


 


gccaaacuggcaaauggaaguuagcaaguuaaaugacauugcucugccuccgaccccugcuuccgcacagugacggccagaa


 


gauggagacgcagaauaaacuuuggucagagucaggagccagugauggugucaagugcuucugcaaggcuguggcccucca


 


aaagggccuaaaguagaagcccuggccugggggaggccccgccugggugaaaugacaagaagugcuucagccacaggcaggu


 


cacagaggacagggcucaguucuuaccacagagagagaggagaacccuuuuauuccucccuuauuuuagucuggaaaguuuc


 


ggcugaggugagcgcagcacagguuuugaaucacauacacauuggggacuuuguuuuugccauuuauacuugagaccagcu


 


uugcagugugauucuuucaaaggauugguuucaagaauauagaggcuggaaauuacgguacagaaauggagcuagaaaaug


 


aguuuguguuacacagagaugucaucuucuccagaguuaucuuguuucuuauuccuagucuuuccagucaaauccgugga


 


uguagcuaaguauaucuaaaacucauuuuuccacuauuguugguauuugaaguugaacagcuguacauugcugugggggag


 


ccaaaggauuggaacccucauuaauuuaauugcuuggaaaugcagcuaaaauucuucuuuggcauuuuguuuugaaaguuu


 


aggcauuuuacucuacuuuagauuuuaguuugcuugcaguuuuuuguguagauuugaaaauuguauaccaauguguuuuc


 


uguaggcuuaaaauacacugcacuuuguuuagaaaaaaaucuggagaugaaaauauguauuauaaagaagagaugucaagaa


 


uuugagauaacuccuugagaaaguuggcuuuaugucaucagcaaaggacacuuaacgucaagcauacacugugguuuuuuu


 


guuuuuuuguuuuuuuuuuucaaauuagaaaguuuaaugaccguuacagauggacagugucuuuuuauuuauaggaguuu


 


uucaggaugucagaguagauagguaggaaaauuguuauuagaacauucgcuucuaccuugaaaaggauguuaaugugguca


 


uguucuuagcaccacagugucugggcaucugggaaacuccgagacuuuuuuaaagugucaugaugugaucacaccugcagu


 


uuggggcaucgaauccagggccuugcaugucuucuguaagagcucucaucgcugaccuguaucccccgcaagagcaaugacu


 


uuugcuaacaguauuucuuuucuguuguaaaguggacagaugauacacuuggucgcaaagguaaauuauucaaaauccaca


 


gugaaaaccucaccacacuuucccauuuaaacuauuuccauaucucagagguuucugacaugcaaacuugaacccuugaaag


 


aagaguuuucuuaaaaauuauaaaaaucacgaguuacaauuugcacaauauuuuuuguugaacuuuauaccuuguuuaca


 


auaaagacuuuucuuug


 









66
AI787713
uugucanuugcacgacagaaacugcaggaagaugagaugcgccgggcugcggaggagcgc




aggaggguaaaggcugaagaguuagcugccagacaaaggguucuagaaaaaauugaaagg




gacaaagcagagagagccaagaaguauggugguaguguggguucucggucauccccacca




gcaacagacccagguccuguuccuucuucucccagccaggagcccccuacuaagcgggag




uaugaccagugucguauacagguuaggcugccugaugggacuucacugacccagacuuuc




cgggcccgggaacagcuggcagcugugaggcucuacguggagcuucaccguggggaggag




ccuggacaggaccaggacccugugcaguugcucaguggcuuccccagacgggcuuucuca




gaggcugauauggaacggccucugcaggaacugggacucgugccuucugcuguccucauu




guggccaagaagugucccagcugaggguucuccaucccaccaucuc


 


67
AI853531
uuuuuuuuuuuuuuuuucacaaauaaguaauauaacuuuauuaaaaugaaaagacaauau




ucaaaauaaugcaacaaaaugaauaaauccuuuguccaauacuguacacacagugcggag




aucagugcauuuuucuaaagcauguuuuaaccuucauuuaguucauacuaaaguaagcuu




uaaauagcucaaauaaugucauucagcaguuuaaacugaacagcuuguugggacauggca




gcagugucccugcuagcaagcaccuucucuuuguguuuaucugcacaagauaaacaauca




gaggauguaaaaacugaacacaaacugcgugucucacugaaucucagggcagugaagcag




ccagcgugaguuuucaaagcaggaagaugcugaagugaccucuggcauuaagacguucug




ugcua


 


68
X14678
Sequence below.







uucauuggaaagcacauugcucuucucaguaauuucuuuaguaucuucaugaauuuuuuccuuuugcgucguuauuucag


 


caauucuaucugcagaucauaaagguaguauugacagaugugauucuuuuucuuaaacauuucauuuccaggguaaggaac


 


ucaauggcuauguuuuucucucccucuagugcauccuucuccuuuucuaccauuuucacucuauuuaacuucaucauguuc


 


agucuggccuuuggguuucaucauagcaaucuguucaacuucacccugcaagauuaaaaaucgauuauggucuaagucaau


 


gccauggcuucuaaggagauuuccaacaucuuuaaacgucuucuucuucccacuuaugugguagacagaagugcuaucucu


 


guaggcgguucuggauacauagaaguugcuguuaggaaggacuucguaaucaucuccuuccuuaucaauuaucuuuugaaa


 


augaacuucuacaguacaacucugaauauccuuguguucaucagaauuauguaucaguaccgauagcuuuuuagaccuuau


 


uuuuugugcucgauagccaaacacaaaaagcauggaaucaauaacauuggauuuuccacugccauuugguccaauaauacag


 


gaaaagcgcuuauggaaaggucccacaaguuucucuccagcauaggacuugaaguuuugguuuacaauaugaguuaucaug


 


agacgaggagcuccagcuucacuggccauggcuggagguggggguggagggauacuauucaaaaucuccucuaaacuucug


 


uuauccagcuccucaccuggaggcuuugcgggugcagcgcuccccucaccuacuucgccuacugcaacucccaccaccuccu


 


cucgauacaagaccgagcucugucggaccuacucagaaagcgggcguugucgcuacggggccaagugccaguuugcucacgg


 


ccugggugaacuuucgccaagccaaucgccaccccaaguacaaaacggaacucugccacaaguucuaccuccagggccgcugcc


 


ccuauggcucucgaugccacuucauccacaaccccaccgaggaccuagcucucccuggccagccccaugugcugcgacaaagc


 


aucagcuucuccggcuugccucaggccgcagaagcucgccgccaccuccaggcuuuucuggcccuucccuguccucuuguuc


 


cuuuucgccuuccagcuccccaccgcccccuggggaucuuccacuuuccccuucugccuucucugcugccccugggaccccu


 


gugacucgaagagacccuaaccaggccuguugccccuccugccgaaggucuacuacccccagcaccaucugggggcccuugg


 


guggccuggcucggagcccaucugcccacucucugggauccgauccugaugacuacgccagcagcggcagcagccugggggg


 


gucagacucaccugucuuugaggcagggguguuugggccuccccagaccccugcacccccaaggcgucuccccaucuucaau


 


cguaucucugucucugagugacaagugccuaccuacccaguauggaucagcuagaucucaaagagagggcagggacugcuca


 


uugcuguggggaccuggggcacuccucuaaguuaauaagucccaucuucuggacauuccaagaugcaauaacccauuucccu


 


ggugcugggcuggggcaggucccuaguuugcaaauucaguguuuggguggauccguuccuaggguaccuaagauguuuga


 


gggagacaguugacaguuggucuuccaggccccaagucuucuguuguuuuugagauaggagcuuauuaugguaccccaggc


 


uggcuuugaacucaauauaauccugccuuagccuuuuccaaguucugggguuacagguaugcaccagccccucugcaacucu


 


ggucuccuggaaucuuaagugcugugaagagccggcucccacaauacuauccuaauuuuuacuagacccugaaguucagug


 


uccgguggucgaagccucuccugagaauccuggugcucaaauuucccuccuaaagcaaauagccaaagccauugccaaaucc


 


cuucucccccaaccagugggcccuuuauuuaugacgacuuuauuuauuguauuaagauuuuauaguauuuauauauauugg


 


gucgucuacuccguuuuucuuuuuguaauguuaaaacugauacuguauuaaguauaugcuauaauauauuaauauauugcu


 









69
AI854358
cggacgcugcagaccugaccgacgugcugugcgaguucgacgcggugcuggccgacuucg




cgucgcccuuccacgagcgcacuuccacuaugaggagcaccuagagcgcaugaagcggcg




cagcagcgccagcgucagcgacagcagcggcuucagcgacucggagagugcagacucagu




guacagggacagcuucaccuucagugaugagaagcugaauucuccaaccaacuccucucc




agcucuccugcccuccgcugucacuccucggaaagccaaauuaggugacacuaaagagcu




cgaagacuucauugccgaucuggacaggaccuuagcauguaugugaagcaaggaguuugg




gguc


 


70
X67668
ccgggccgaggagaagucugcaaaacaagaggcuggggauugccuuagcgagaaaucagu




ucucuuaggagguuagggaaggaagucuuucucuggaggucugagggaagcgcucguguc




agaugccggguugucauggguaagggugaccccaucaagccgcugggcaaaauguccucu




uacgccuuuuuugugcagaccugccgggaggagcacaagaagaagcaucccaauucgucg




gucaacuucgccgagaucuccaagaaaugcuccaagagauggaagaccaugucugcaaag




gaaaacucgaaguuugaagauuuggccaagagcgacaaagcuuguuauuacagggagaug




aagaacuauguuucucccaaaggugauaagaaaggaaagaaaaaagauccaaaugcuccg




aagagaccaccgucugccuucugccuguuuugcucugaaaaucgcccaaagaucaaaauu




gaauacccgggccugucuauuggagauacugcgaagaaacugggugagauguggucugag




cagucugccaaagagaaacaaccguaugagcagaaagcagcuaaacuaaaggagaaguau




gaaaaggauuuugcugcauaccgugucaagggcaaaagugaagcaggaaagaaggguccu




gguaggccagcaggcucaaagaagaaugacucagaagaugaggaagaagaagaggaggaa




gaugaagagggggaagaagaggaugaagaauaaguggcuauccuaaaguguggaguauau




gugcucaggcaguuauuuugcuaagaauguaaauucaagcgcagcucaacauuagcucca




guaggaa


 


71
K02236
aucacgcuccuagaacucuucaaaccgaucucucgucgaucuucaa




ccgccgccuccacucgccauggaccccaacugcuccugugccuccgguaagggggacugc




ugacgggauuucugggagagcuagacaggcuuuuuggccccuccuuuaguaauuacuuua




aggguacgaccggcuaccccuuccgaaugaauucugaagcacuccugcuccuuuaaacua




guccuugagauaguggcucgccuacccgggugauuugccucaccuuccuaggagaacagc




guucagguacucccgggucccacucaaccgcgcucacugacugccuucuacuuuuagaug




gauccugcuccugcgcuggcgccugcaaaugcaaacaaugcaaauguacuuccugcaaga




aaaguaaguuggaucuucucugccauuuccccgucacucuccuggggucccuagcccgcc




gcgccgcgccuucccucccgggagcguucagguggugugccucugacaagguuucucgcu




cacguucaacucuucucuccccacaggcugcugcuccugcugccccgugggcugugcgaa




gugcucccagggcugcaucugcaaagaggcuuccgacaagugcagcugcugugccugaag




gggggcggagggguccccacaucuguguaaauagaccauguagaagccuagccuuuuuug




uacaacccugacucguucuccauaacuuuuucuauaaagcauguaacugacaauaaaagc




cguugacuugauu


 


72
X51829
Sequence below.







gcucugaguuuguggaagauuacaugcgauaucccgcgcgaccccgcaucccuuugccggccgggacagccuuugcuacagc


 


cugugaaacauugcguccccgagccccacgccugagggcgacaugaacccgcuggcuucgcgagcaguccggacccacgauc


 


gcuuuuggcaaccagaaccggcgcuucagcccccggggugacgugcagcccgccgcccagacacauggccccgagcccaagac


 


cccagcauguccugcacuggagggacgcccacaacuucuaucuccuguccccacugaugggcuugcucagucgggccuggag


 


ccgccugaggggcccagaagucccagaggcauggcuggcaaaaacaguaacaggagcagaucagauagaagcugcggcucug


 


cugacaccuaccccugucucugguaaccuccucccucauggggagacugaagaaaguggaucuccugaacagagucaagcag


 


cccagaggcucugccuuguggaagcugaaaguuccccuccugaaacuuggggacuuucaaauguugaugaguacaaugcaaa


 


gccaggacaagaugaccuuagagagaaggaaauggaacgcacagcuggcaaggccacacuacagcccgcuggccugcaagggg


 


cugauaagaggcuuggggaggugguggcuagagaagagggaguggcugagcccgcuuaucccacaucacagcuggagggug


 


guccagcugagaaugaagaggauggagaaacagugaagacuuaccaagcuucugcugcuuccauagcuccgggauacaaacc


 


cagcaccccugugccuuucuugggggaggcagaacaucaagccacggaagaaaaaggaacagaaaacaaggcugaccccucca


 


acucuccuucuucaggcucccacuccagagccugggaguacuacucuagagagaagccuaagcaggagggagaagccaaggu


 


agaggcacacagggcagggcagggucacccuugucggaaugcugaggcugaggaaggaggaccugagacaacuuuugucug


 


uacuggaaaugccuuccugaaggccuggguguaucgcccaggagaggacacagaggaagaagacaacagcgauucggauuca


 


gcugaggaagacacagcucagaccggugccaccccccauacaagugccuuccugaaggccuggguguaucgcccaggagagg


 


acacagaggaagaagacagcgauucggauucagcugaggaagacacagcucagaccggugccaccccccauacaagugccuuc


 


cugaaggccuggguguaucgcccaggagaggacacagaggaagaaaacagcgauuuggauucagcugaggaagacacagcuc


 


agaccggugccaccccccauacaagugccuuccugaaggccuggguguaucgcccaggagaggacacagaggaagaaaacagc


 


gauuuggauucagcugaggaagacacagcucagaccggugccaccccacauacaagucccuuccugaaggccuggguguauc


 


gcccaggagaggacacagaagaugacacagaagaggaagaggacagugagaauguggccccaggugacucagaaacagcugac


 


ucaagccagagucccugccuucagccccagcguugucuaccaggagagaagaccaagggacguggggaagagcccccucucu


 


uccagguggccuucuauuuacccggagagaagccagaaucaccuugggcugcaccuaagcugccccuucgacugcagaggcg


 


gcucagauuguucaaagcccccacccgggaucaggaccccgagauuccucuaaaagcucggaagguacacuucgcugagaaa


 


gucacaguccauuuccuugcugucugggcaggaccagcccaagcugcccgucgaggucccugggagcaguuugcacgagauc


 


gaagccgcuuugcucgacgcauugcccaggcagaggagaagcugggucccuaccuuaccccugauuccagggccagagcaug


 


ggcacgccuuagaaacccaucucuuccacaguccgagccucgcucuuccucugaggccacucccuugacccaagaugugacca


 


cacccucuccccuucccagugaaaccccuucgcccagccuguacuugggagggaggcggggcuaagccugaguaguuuccua


 


uuauuuauuuauuuauuuauuugaauaagaaauaaagccuuuuaauuuguagugau


 









73
AW048937
uuuuuuuuuuuuuuuuuaaucaucgagaaguauuuauugagcaccagcuuuggggucgg




gugugaggacucgggacaaugcagggugcugucccuucucgugagacgcuuacaaucuga




guggagacagggagggagccacaauacauguucuuggggugcgggcuaaggguagacagu




ccagaccaggauguuacagaaacagggauguuuggggcuggagucagacccacuaagugcu




uugacacccacgguauucaacacugagaaaggaucagccauugcucaguguccugugagc




ucccuuagcccccaagacaccaucuuggccuggcuccuuguacaacugcuacuaa


 


74
AV139913
cccaaaacccauucagcaaaguucccaaccucgacgggcuagcaguauuuaaccagugau




ggguucacuguuguauuuggugaauacuguauuuuguuucaguucuuucucccagauaa




uuugaaaacguuccaggagaaggcagcuuccuauaugcagcgugugcuuucuuauucuuu




uuuuuaauauaugacaguuauuugagaacccauuucuacuuugaauucauuuucguugaa




agugauguuucuucaccuaccauuuuccuauuaaaguucuguauucaaau


 


75
M32490
Sequence below.







agaccgugagcgagagcgccccagagaagcgccugcaaucucugcgccuccuccgccagcaccucgagagaaggacacccgcc


 


gccucggcccucgccucaccgcacuccgggcgcauuugaucccgcugcucgccggcuuguugguucugugucgccgcgcuc


 


gccccgguuccuccugcgcgccacaaugagcuccagcaccuucaggacgcucgcugucgccgucacccuucuccacuugacca


 


gacuggcgcucuccaccugccccgccgccugccacugcccucuggaggcacccaagugcgccccgggagucggguugguccg


 


ggacggcugcggcugcuguaaggucugcgcuaaacaacucaacgaggacugcagcaaaacucagcccugcgaccacaccaagg


 


gguuggaaugcaauuucggcgccagcuccaccgcucugaaagggaucugcagagcucagucagaaggcagacccugugaaua


 


uaacuccagaaucuaccaaaacggggaaagcuuccagcccaacuguaaacaccagugcacauguauugauggcgccgugggc


 


ugcauuccucuguguccccaagaacugucucuccccaaucugggcugucccaacccccggcuggugaaagucagcgggcagu


 


gcugugaagaguggguuugugaugaagacagcauuaaggacucccuggacgaccaggaugaccuccucggacucgaugccu


 


cggagguggaguuaacgagaaacaaugaguuaaucgcaauuggaaaaggcagcucacugaagaggcuuccugucuuuggcac


 


cgaaccgcgaguucuuuucaacccucugcacgcccauggccagaaaugcaucguucagaccacgucuuggucccagugcucc


 


aagagcugcggaacuggcaucuccacacgaguuaccaaugacaacccagagugccgccuggugaaagagacccggaucugug


 


aagugcguccuuguggacaaccaguguacagcagccuaaaaaagggcaagaaaugcagcaagaccaagaaauccccagaacca


 


gucagauuuacuuaugcaggaugcuccagugucaagaaauaccggcccaaauacugcggcuccugcguagauggccggugcu


 


gcacaccucugcagaccagaacugugaagaugcgguuccgaugcgaagauggagagauguuuuccaagaaugucaugaugau


 


ccaguccugcaaauguaacuacaacugcccgcaucccaacgaggcaucguuccgacuguacagccuauucaaugacauccaca


 


aguucagggacuaagugccuccaggguuccuagugugggcuggacagaggagaagcgcaagcaucauggagacgugggugg


 


gcggaggaugaauggugccuugcucauucuugaguagcauuaggguauuucaaaacugccaaggggcugauguggacggac


 


agcagcgcagccgcaguuggagaaugccaaggggcugauguggacggacagcagcgcagccgcaguuggagaagacuucgcu


 


ucauaguacuggagcgggcauuauugcuccauauuggagcauguuuacggaugacguucuguuuucuguuuguaaauuau


 


uugcuaaguguauuuuuuugcuccagacccccccccccuuucuugguucuacaauuguaauagagacaaaauaagauuagu


 


ugggccaagugaaagcccugcuuguccuuugacagaaguaaaugaaagcgccucucauuccuucccgagcggagggggacac


 


ucugugaguguccuuggggcagcuaccugcacucuaaaacugcaaacagaaaccagguguuuuaagauugaauguuuuuuu


 


auuuaucaaaguguagcuuuuggggagggaggggaaauguaauacuggaauaauuuguaaaugauuuuaauuuuauauca


 


gugaagagaauuuauuuauaaaauuaaucauuuaauaaagaaauauuuaccuaaa


 









76
AI121305
ccaauaccacagccgugaccacagccaagaccacagccaaaagccuggccauccgcacuc




ucggcagcccccuggcagugcccuccauauccugcuuguuuuucucauuaguaaacuccu




cuucuaaagaaaacuggggaagcagaucuccaaccuccaggucauccucccgagcucauu




ucaggccagugcuuaaacauacccgaaugaagguuuuauguccucaguccgcagcuccac




caccuuggaccacagaccugcaacacuagugcacuugagggauacaaaugcuugccugga




ucuuucagggcacaaauuccgcuucuuguaaauacuuaguccauccauccugcgugua


 


77
U35374
auggagaacgaguucacauacgaagauuaugagaccacugccaaguggcuucugcaacac




acugaauaucgaccucaaguggcagugaucugugguuccggcuuaggagggcugacugcu




cacuuaaaggaggcucagaucuuugacuacaaugagauacccaacuuuccccaaagcaca




gugcaaggucacgcaggccgacugguguuuggauugcugaauggcagaugcugugugaug




augcaaggccgguuccauauguaugaaggauacucacugucaaaggugacauucccagug




agaguuuuccaucuucuggguguggaaacuuugguggucaccaaugcugcuggaggacuc




aaccccaauuuugaaguuggagauauuaugcugauccgugaucacaucaaccuaccuggu




uucuguggccagaacccucuccggggccccaacgaugaaagguuuggaguucguuuuccu




gccaugucugaugcuuaugaccgggauaugaggcagaaggcuuucagugccuggaaacaa




augggggagcaacgaaagcuacaagaaggcaccuacgugauguuggcaggccccaacuuu




gagacuguggcagagagucgucugcuaaagaugcugggggcagaugcuguuggcaugagc




acagucccagaaguuaucgucgcaaggcacugugggcuccgugucuuugguuucucacuc




auuacgaacaagguugucauggauuaugagaacuuggagaaggccaaucacauggaaguu




cuggaugccgggaaagcagcugcacagacauuggaaagguuugucuccauucuuauggag




agcauuccacucccggaucguggcagcuga


 


78
X15643
Sequence below.







uuccaggacagcuggggcuccacgagagaaacccugccucccccccaaaaauggcccaaaguucacugacaaacucacauuug


 


ucugauauuuagcuauguaacagcacuuacgguagcaauagaauuugauucucacucaucacaaugaaaauggcuggcgcuc


 


ucucucucccucucuccccauuucaaaucugcaagcacaccccuuagagauggagagaauuugauccauuggagaaucgagc


 


uaaaaauaccaccauggaauugugggaaggauuaaaugcaauaaugcacaaaaggcacauagcagaaugugcccuaaauguca


 


gccauuguuaugguauuauguaaucuacaaaguauguuugcuuacuccgugugaaagacuuucagucuaucaaacauaaua


 


caugugaaaucaaaccuugaaaauuaauuuuuuucccaacagucaagacauuugccagcugcagagauuagcauuucaugaa


 


ucuuagucuugucugauuuuuuuaaugggaaggaacaacuauccucaacuauccuuuuuuuuuuucuguaguuuuaaaau


 


gaacuccacaaaacauguuuuuaauauagggaauuauaugaaauuguggggugggcagcgagguuaaaggcagaaauagccc


 


aaugguggcacauucacugacacagccuaaaagauuagcaaauuacccagccaacacauacaauuaauacaauuaauauuuuu


 


auaguuaaaacagaguuacuaaagaaauuguuugaaaagaaaauuaugaagacuggaaagacggcucagugcuuaagagcuu


 


uggcuagucuuccagagaaccagggucauccagcacucacaaggcagcuugugagcugauacuaucuguauauucaguccua


 


gggaaucugaugcuuuguccugaccuccaaaacaggcacaaauguggugcacaggcaaauguagagauaagacucccaugca


 


cagaacauaaauaacguaguuuaauuuuuuaaauuguaaaacugaaaaugguugcacuugcauuuuuauuuucagcacauc


 


cccagauauccgccauauaacaagaaaaugaugccacacucccaagaauuaagaauuacaccucccaacccuacccaaaugugu


 


auacucuaggucuaaagaaaugcaaaggaugaaguuacugccuugugcgguucucaaggagggaggaugccaaaaaaauauu


 


uuuucacaaagugugcugagaaacucuguagcuguuggagucaucuccugugcucuugccaaauaacugaaaggggauaca


 


cuggaugucugugaauggggugucacuuaugagugcuagaagcggguaccuggauguggacacggugucugagugguccg


 


cacuccaugucuccacaggagcgcuuauguguguuucuuuccuccugcuucuggguguuccuggguuuguuuacagccacc


 


ucucuguuggaccaggagacagcugucgucuccagaaugagcgggcacgggugugucucgguggcuguggcugugguucg


 


gcauaagucugagcauguccuggucgucagggugcguuugugcugugugugcguguccgggugagcuugcucuuucuguu


 


ccuaaaagaaaaugcacccugcgcuaccggcguccagagacucucagcccgcagaggugaccugaacggacagguagcaccuc


 


cagacagcgccugguuggcggguugcacagcagccccagauuucucucucuggugccccagcuaggguagcuggaagggag


 


cgguggccuggccuccggggagccgcugggccccgccgggcuaacccaggaggaggccggcuaggcugggaggguuagccc


 


uuggugcccuacgccugcccgggccagucgcggccgccggccauuggcccaaagaauuguugcacgucacuggcaauucccc


 


uagaagucugugcacauaacgggcagggcgcacugcaaggcugcuucucccgcauuuaggcugcggcugcaggcaccgcgag


 


cccggagcacccacgagcuuagugugcaggacgcaccccagcacagccaccuacggccgcugaaugaagcuuccaggaguccg


 


cccccggccgucgccccgucggaggugcacccgcugagagcgccuggaccgaaaggccggugcgcucaccugcuaaccugcc


 


agccauggggccacacgggaacgacagcgacuucuugcuggcacccaacggaagccgagcgccacaccacgacgucacucagg


 


aacgggacgaagcguggguugugggcauggccauccucaugucgguuaucguccuggccaucguguuuggcaacgugcugg


 


ucaucacagccauugccaaguucgagcgacuacaaaccgucaccaacuacuucauaaucuccuuggcgugugcugaucuagu


 


caugggccuagcgguggugccguuuggggccgucacaccucuaugaaaauguggaauuuuggcaacuucuggugcgaguu


 


cuggacuuccauugauguguugugcgucacagccagcaucgagacccugugcgugauugcaguggaucgcuauguugcuau


 


cacaucgcccuucaaguaccagagccugcugaccaagaauaaggcccgaguggucauccugaugguauggauuguaucuggc


 


cuuaccuccuuuuugccuauccagaugcacugguaccgugccacccacaagaaagcuaucgauuguuacaccgaggagacuu


 


gcugugacuucuucacgaaccaggccuacgccaucgcguccucgauugugucuuucuacgugccccugguggugauggucu


 


uugucuauucccgggucuuccagguggccaaaaggcagcugcagaagauagacaaaucugaaggaagauuccacgcccaaaa


 


ccucagccagguggagcaggaugggcggacgggccacggacuccgaagguccuccaaguucugcuugaaagagcacaaagcc


 


cucaagacuuuaggcaucaucaugggcacauucacccucugcuggcugcccuucuucauugucaauaucgugcacguuauca


 


gggacaaccucaucccuaaggaaguuuacauucuccuuaacugguugggcuacgucaacucugccuucaauccucuuaucua


 


cugucggaguccagauuucaggauugccuuucaagagcuucugugccuucgcaggucuuccuucgaaaccuaugggaacgg


 


cuacucuagcaauagcaacggcagaacggacuacacaggggagccaaacacuugucagcuggggcaggagagagaacaggaac


 


ugcugugugaggaucccccaggcauggaaggcuuugugaacugucaagguacugugccuagccuuagcguugacucccaag


 


gaaggaacuguaguacaaaugacucgccacuguaauacaggcuuucuacucucuaagaccccuccuugacaggacacuaacca


 


gacuauuuaacuugaguguaauaacuuuagaauaaaauuguauagagauuugcagaagggggggcacauccuucucgccuu


 


uuuuuaauuuuuauuuuauuuuuuagcugcaaacaagagagagaacuguauuugagugcuuauuguucuuguauaguuca


 


guuccucuuguauggaacuuaaagguuucugucugaagaguguugguucugaggacugagucugucugucugucugucug


 


ucugucugucuggaugauguuuucauguaucuaccucacuggucaaguauuaagaaugauauauugcugcuggaaaucc


 


auaucuaaaggagagaguuuucuuccuguacccuuggacuugaaauauccugugucuuggaccuuucugcugugacaaugg


 


gcccuuucucucucacuccacuuauuuacucaaauggauucgaggcagggauuugagggacaacacuaguuguuuuguuuu


 


uguuuuuguuuuuuuguuuguuugguucguuuuugguuuguuguuguuuuuugggguuuguuuuuguuuuuguuuuu


 


uuggguuuuuuuuuuuugcugagaaaagucuaaaguuuacaguaaauaaauuguuuaaccaugacuucauugcacccguuu


 


cuucaaaaccucuugacucuggaguguccuugucucucccacuggaaaccacagguaaacuaugugucgugaccgaugagug


 


gcuuaauguguaagaguaccagaauggcaugcuugcaugcaccgugccuagcccuuccgugugugucuucagagcuccaga


 


ugcaaaccugugccuucccuaacuucacucgugucccaaagcaguccugccuguucacagcauaacccaguauguccuacag


 


uugcucuucugugcugucacuccagaaacccugacucacggaaacagaguuauggacauauguuuuuguccccauaugcuc


 


ugacaccaccuucagccuuacuugcuuaauaacuguguauauuuacaucacugcgucucuuacaguagugccuuuguacug


 


caucagggcuugguguguucaggaugaggaagauguucuguguaauagcuguucaagcaucuagaaauucugagggaaauc


 


aaaggccucggucagagagagagagagagagcaaagcuuuaaaaaacauagcuggugaaugcuucacgcccuucagccucuc


 


cucgcuccgucugcugucccgugucuucuguucccaauucucugcacuucuguguaaaccaggcuucccaugucuggcauu


 


ccgugcauuauaugauauuuggcggcacgucuguaccaguaaauucugguagcacccccuaguuacaauaauugcagacacu


 


cagcgcguacgacccccuaguuacauaugcagacacu


 









79
AI849109
uuuuuuuuuuuuuuuuuaagcguccaggcuguacuuuauuuuacacaagugguggcccc




agaaccacagggacaugaccuggagaguaggcacagugccugaggcugcaagagccaaaua




cagggauucaugccuucuccuugguccccaugaccaaauuaaaaaaaaaaaaaacaacaa




aucacacagcacacaucgccacacccauccccuccuuccuuucagcaacagccaauucag




cuuucuagccaaagacaguggcuacaacugaauuuacagagaaccaugcagccaagaaac




cagagccacggaggggagaggcuugcguugacuucccacaugugcugucccauagcagcu




gagugaccccacca


 


80
U70132
agaaagauaagggccagcaaggaaagaaugaggaugugggcgccgaggacccguccaaga




agaagcggcaacgccggcagaggacucauuucacuagccagcagcugcaggagcuggaag




ccacuuuccagagaaaccgcuacccagacauguccacucgcgaagaaaucgccgugugga




ccaaccuuacggaagcccgaguccggguuugguucaagaaucgccgggccaaauggagaa




agcgggaacgcaaccagcaggccgagcugugcaagaauggcuuugggccgcaguucaacg




ggcucaugcagcccuacgaugacauguaccccggcuauucguacaacaauugggcugcca




agggccucacgucagcgucucuguccaccaagagcuuccccuucuucaacuccaugaacg




ucaauccccuguccucucagaguauguuuuccccgcccaacuccaucucaucuaugagua




ugucguccagcauggugcccuccgcggugaccggcgucccgggcuccagccucaauagcc




ugaauaacuugaacaaccugagcagcccgucgcugaauuccgcggugcccacgcccgccu




guccuuacgcgccgccgacuccuccguacguuuauagggacacauguaacucgagccugg




ccagccugagacugaaagcaaagcagcacuccagcuucggcuacgccagcgugcagaacc




cggccuccaaccugagugcuugccaguaugcagucgaccggccggugugaaccgcgccca




gggcgcggggauccgaggacugucggagugggcaacucugccccagaaagacugagaauu




gugcuagaaguucgugcgcacuaugggaaggaagaggggggaaaaaagaucagaggaaaa




gaaaccacugaauucaaagagagagcgccuuugauuucaaaggaauguccccaagugucu




acgucuuucgcuaagaguauucccaacaguuggaggacgcguacgcccacaaauguuuga




cuggauaugacauuuuaacauuacuauaagcuuguuauuuuuuaaguuuagcauuguuaa




cauuaaaaugacugaaaggauguauauauaucgaaaugucaaauuaauuuuauaaaagca




guuguuaguacuaucacuacaguguuuuuaaaggcuaggcuuuaaaauaaagcauguuau




acagaaucaguuaggauuuuucgcuugcgagcaaaggaauguauauacuaaaugccacac




uguauguuucuaacauauuauuauu


 


81
M13805
cugagaggccaggugggcggcgaaaucaacguggagauggaugccgcucccgguguggac




cugagccgcauccugucagagaugcgugaucaguacgagaagauggcggagaagaaccgc




aaggaugccgaagacugguucuucagcaagaccgaggagcugaaccgcgagguggccacc




aacagcgagcuggugcagagcggcaagagcgagaucuccgagcucaggcgcaccaugcag




gcccuggagauugagcugcagucccagcucagcaugaaagcaucucuggagggcagccug




gcagagacagagaaccgcuacugcgugcagcugucucagauccaggggcugaucggcagu




guggaggagcagcuggcucagcugcgcugcgagauggagcagcagaaccaggaguacaag




auccugcuggaugugaagacaaggcuggagcaggagaucgccaccuaccgccgucugcug




gagggagaggaugcccaccugacucaguacaagccaaaagaaccugugaccacccgccag




gugcgcaccauuguggaagaaguucaggauggcaaggucaucucaucccgggaacaggug




caccagaccacccguuaaggacucagcuccuuccgcccaguuccccgaggcugcagagag




gcagcuucccucuccgcuccggcauuacccuccugcuacagccucuccccagcauuccua




ugcuugagaccauuaaagcuugcugaccugaagugaacuguggccuuuguucugaacacu




gaaauaaaugaccauggugac


 


82
AV138783
ccccaggggugaaaugaggauuccccacccugcggaacagugaaauguguauaauuaag




aggagggcgacgacccuugccgcgggacccgggacucgagcccgggacuucgcagcuaca




gcaaaucuauuuuuaauauugugcugagcaagacagaucgcuugcauauuuuuaaaaauu




uuuacuacagagacauuccaauaaauucguuaagcc


 


83
K02927
Sequence below.







cugacagucgucucugucccuucuucgccucggagcugcuaacuggucucgaaccucucagcacuucagcuucuagcggcga


 


ugcaugugaucaagcgagauggccgccaagagcgaguuauguuugacaaauuacaucacgaauccagaaacucuguuaugg


 


acucaacauggacuuuguugauccugcugcagaucaccaugaaaguaauccaaggccuauaguggggucaccacaguggaa


 


cuggacacccuggcugcugagacagccgcgaccuugaccacgaagcacccugacuaugccauccuggcagcaaggauagccg


 


ucucuaacuugcacaaagaaacaaagaaaguguucagugaugugauggaggaucucuacaacuacauaaauccgcacaacgg


 


cagacacucucccaugguggccagcucaacacucgacauuguuauggccaauaaggaucgccugaauucugccauuaucuau


 


gaccgagauuucucuuauaacuacuuuggcuuuaagacacuggaacggucauauuuguugaagaucaaugguaaaguggcu


 


gaaagaccacagcauauguugaugaggguuucuguggggauucacaaagaagauauugaugcugcaauugaaaccuacaacc


 


uacuuucugagaagugguucacucaugccccuccuacucucuucaaugcugggaccaaccgcccacagcugucuagcuguuu


 


ccucuugaguaugaaagaugacagcauugaaggaauuuaugauacucugaagcagugugccuugauuucuaaguccgcugg


 


gggaauugguguugcugugaguuguauucgggccacugguagcuacaucgcugggacuaauggcaauucuaauggccuug


 


ugccaaugcugagaguauauaacaacacagcucgcuauguggaucaagguggaaacaagcgcccaggcgcguuugcuauuua


 


ccuggagccuuggcacuuagacaucuuugaguuccuugacuugaagaagaacacaggcaaggaagaacagcgagcacgcgau


 


cucuucuuugcacuuuggaucccagaucucuucaugaagcgagugggagacuaaccaggacuggucauugaugugucccaau


 


gaguguccuggucuggacgaggucuggggagaggaguuugagaaguuauaugaaaguuacgagaagcagggucguguccga


 


aaaguuguaaaagcucagcagcuuugguaugccaucauugagucccagacggagaccgguaccccauacaugcucuacaaag


 


auuccuguaaccggaagagcaaccagcagaaccugggaaccaucaaaugcagcaaccuguguacagaaauaguagaguacacc


 


aguaaagaugagguugcaguuuguaacuuggcuucucuggcucugaauauguaugucacaccggaacauacguaugacuuu


 


gagaaacuggcagaagucacuaaagucauuguccgaaaucugaauaaaauaauugauauaaacuacuacccuauuccagagg


 


cacacuuaucaaacaaacgccaucggcccauuggaauugggguacaagguuuagcagaugcuuucauccugaugagauaccc


 


cuuugagagcccagaagcccaguuauuaaauaagcagaucuuugaaaccauuuacuauggagcccuggaagccagcugugaa


 


cuagccaaggaguauggccccuaugaaacguaugagggaucuccagucagcaaggguauucuucaguaugacauguggaau


 


guugcuccuacagaccugugggacuggaagccucucaaggagaagauugcaaaguaugguauaaggaacaguuuacuuauu


 


gccccaaugccuacugcuucaacugcccagauucuggggaauaaugaguccauugagccuuauaccaguaacaucuacacuc


 


gaagagucuugucaggggaauuucagauugugaauccucacuuacugaaagaucuuacugagcggggcuuguggaaugaga


 


gaugaaaaucagauuauugcaugcaauggcuccauucagagcauaccagaaauuccugaugaccugaagcaacucuauaag


 


accgugugggaaaucucucagaagacuguucucaagauggcagccgagagaggugcuuucaucgaucagagccagucuuuaa


 


acauccauauugcugagcccaacuauggcaaacucacuaguaugcacuucuacgguuggaagcaggguuuaaagacuggaau


 


guauuacuuaaggacgaggccugccgcuaauccaauccaguucacucugaacaaggaaaaacugaaagauaaggaaaaggcac


 


ugaaggaggaggaggagaaggagaggaacacagcagccauggugugcucuuuggagaacagagaggagugccugaugugug


 


gauccugagaaaagcggggccugggagacgcagcgggcucuccugcccgagaggcagacgauuugagcauagauaggauagu


 


ggguuugcuugguuaucagcagcucugcuuggacgugccugccaggacagggagccacgacuuacaguacuguuucuacac


 


aguguaaauaucauuuuuaacaaacagaaaaccaaagccagcuuugauauuaggaaucaagguagaggcuuugggaauacua


 


aagagccuuccugcaaauagugaggagacuuaggaagucucgucucuccagcuuucccugccuggccauucucaguuuggg


 


caaagagauuuaguuugauuugacugauugccuagaaguaaaaucaagcaauuacucaucagcuaaagaccuuugucuagac


 


aaacuucuauaagucauuuugaaauaaacauuucuaagugau


 









84
X07699
Sequence below.







uugccucagacgcuagcuguagcuggcaggcgguuguacgugcuccagagucgucgguacccgcuacugcagucgcuuucg


 


uguggcuuccgcugagcucuuccgagcugcucgcucuccacacgcgccgccgccguaauccgccaccauggugaagcucgca


 


aagguaagaggccuuggcgcgccgacgcggacgacuaggccccugcuuucggagggacgcgcgcgcgcccgcccguccgucg


 


cggaggggaggagggcuugcgcgcaaucccgggcgcguucgagggcgccaugcugggggggaaagucucgcgcgacuagcg


 


ggaggucucgcggugcuugcccucugacuuagggggaugagaagagcggaggcagguuuccgggagggcgauaucgaggg


 


uucggauguagcgggcgggaggggacggugugaggagagaucggaggagcugagagcggauaggggcacggcgugggaaga


 


gagggccaaccuuaggcggcgagcggucccggggccccgccuccccgcgcacgugcucuggugcgcgcccgccacgugcucu


 


gcggagccccgcacgugucgcgcgacccggggcagugggggagugucuguaguaccccggaaagggggacggcagcguggg


 


gauggauggguggcccggcgaucugcugucucugccggugaccgggauggacacgugguggaccccugagguggcggcgu


 


ggugacuccacgugguggggcuggaagcgagagaaagugggaagcaguuggguuacguggugcugcuuuaagaggugauu


 


ucgagauacccccuuccccagcaaauaacuuaaagggaucccuuuaacuggguuuuuuuuuuuuuuuuuuuuuuuuuuuu


 


uguggaagaugccagaaaauagauggccaggauuaggagacuuuauaaccuguggcuguuucuugguguagaguucuguc


 


ugcucaguuaucugugagaaggaaaaaaaaauuaugcgcgguucgcagaaaaaacugccaggagaaugccaugccuggccaa


 


gaagaagucuuuaugcuuguguccuuuaguaagaaaaaggugguggccaaaggcaaagugacugaaaaugcgugcaauuuu


 


ugugugcguuuguaggcuggcaaaacccacggugaggccaagaaaauggcuccuccuccaaaggagguggaagaggauagu


 


gaagaugaagaaaugucagaagaugaagaugacagcaguggagaagaggagguaagaagcuauuugcagcgaagaauuaaaccgg


 


uggaauugaaugcuggaagucuuagaaauacaggauauguaguaaaugguugaauggcaagccccuuccucccucccuccc


 


ucccucccucccucccucccucccucccuuccuuccuuccuuccuuccuuccuuccuuccuucugcaagacagucggcaaaac


 


aggggacagaaacaggcagaauuuugaguuccaggcaagcagggaguagacauaugaaaccuugucucaagaccguuguu


 


auggucaugcucaaucagauuucuuagaaaagcucaggugcugaguccaguuuuuuuuuuuuuaaaguauugaaagccaug


 


ucuccuuauuucaggguuuaauguuuaucuuugugugugcgcgcacccauuaagcaugcuugguacccucauacuagaaug


 


uacuuggauccccuggaacuggaguuaaagccacaugugaauguuacauguuacaagaguaacacaugugcuuaacuuuug


 


agucaucucuccaguucuugguuguuuguuuuuuuuuuuuuaagccuaucuaauguccauuuucuugugcucaaaguuag


 


ucucuuaauguagcauuggguauaaaggaaugcuuaugauuuguuugcuuucaagguugucaucccucagaaaaaaggcaa


 


aaaggcuaccacaaccccagcaagaaggugguuguuucacaaacaaaaaaggcugcaguucccacaccagcuaagaaagcag


 


cugugaccccaggcaaaaaggcaguagccacaccagcuaagaaaaacauuacaccagccaaagucauuccaacaccggguaaga


 


agggagcugcacaagcaaaagcguugguaccaacuccugguaaaaagggagcugccacuccagcuaagggggcuaagaacgg


 


uaagaaugccaagaaggaagacagugaugaggaugaagaugaagaggaugaagaugauagcgaugaggaugaagaugaugag


 


gaagaggaugaguuugagccaccaauaguaaaaggagugaagccagcaaaagcagcuccugcugcuccugccucagaggaug


 


aggaagaugaugaggaugaagaugaugaggaagaugaugaugaagaggaggaagauggugaguuagaucuuaggauauuua


 


ggguacugcauguacauucccucacuguuucauuagauuaaaaacucauuuugugcucuuaguucuuuccauaacuuaaua


 


gguuuucauuugcuaaguaguuuuuguuuuuuuuaaguauuuguagcauuuaucuugucuggauugguagguagcaaau


 


acauuugccugauuugccaucuuucuuccagacucugaggaagaaguuauggagaucacaacagccaaaggaaagaaaacuc


 


cugcaaaaguuguuccuaugaaagccaagaguguggcugaggaggaggaugaugaggaagaggaugaagaugacgaggaug


 


aggaugaugaggaagaggaugacgaagaugaugaugaggaagaagaggaggaagguaaccauauuaacuuuuaaaguaugc


 


ugaccuaaguaaggcuuacuggcuaugcuaaagugucugcuuacucaugaauggcauuuuaaaacaucuagaaccuguuaaa


 


gcagcaccuggaaaacggaagaaggagaugaccaagcagaaagaagccccugaagccaagaaacagaaaguagaagguaagcc


 


ugcaaaacuggggaaacagaucagaguagcacuagcacaagugaugagugacaaagggacuuaauacugaaccaugggguug


 


aaaugaaauaugcugaugugcuuuauaguuuaugaugaaauuuguugugugcuuaagugggcugaaaguucauuuuuugu


 


gugugcaggcucagaaccaacuacaccuuucaaucuguucauuggaaaccuuaauccaaacaagucuguuaaugaauuaaaa


 


uuugccaucagugaacuuuuugcuaaaaaugaucuugcuguuguggaugucagaacugguacaaauagguaaguuuuaauu


 


gaauguuacauguguaucagcuagaauuuuuaguuuccaguuguauucuucccugccuuuaaacauggggcuauaucuaac


 


uauguuaguaaaagucaguugucuccucucguggccuuaaguacaguuaaggagcugcaguaagaaagacuauaguauuga


 


acuaaaugaucgagucauagggccugcaauuugaaguuccuguguuugacuugauaaagauaaaauaaaauuuaaagaagaa


 


aagauauuaaacacauaaaauuuugugcaguaucuacaacuauggaucugcauagucauaugcuuuuagcuaaaaguauucu


 


cuguacuuuuagcgggguccaugcuagcuacugcuguuaguuacaauauacugaaugaagaaaucgaggugaauuuguugu


 


aaugucuugguacauggacuuguuuuguuuuuuguuuuuuuuucuuuaagauuuguuuauguauaugagcacacuguag


 


cuguccagaugguuuugagccuucaugugguuguugggaauugaauuuuuaggaucucagcucgcucugcucucaguccu


 


ugcuugcucuggcccaaagauuuauuuguuguuauacauaaguacacuguagcugacuuaagaugcaucagaagagggcau


 


uaggucucauuaugggugguggugagccaccaugugguugcugggauuugaacucaggaccuucagaagagcagucaaugu


 


gcuuacccgcugagccaucucuccagccuuuggacuugguuuuauggaagauaagggugaucuaguuuuauuuuuguuag


 


ugcuguagaugcucugugugugugccacaugguauaagugcagaucaccuucucauaccuguaaucuuguuuuuuccaucu


 


ucaaggaaauuugguuauguggacuuugagucugcugaagaccuagaaaaggccuuggagcucacugguuuaaaaguguuu


 


ggcaaugaaauuaaacuagaaaaaccaaaaggaagagauaguaagaaagguauguaagggggucugggugacuggauacuaa


 


cagacuuaggcagucuggugccucuuccuuaguuucauccucauugugaaccaaugagaugucauaggucaugugcuuguu


 


gacagguuugauuccugggauauauaaugucagggcugacaggaggaauagcuuagugaguaaagaugcuugcugcaaaau


 


guuugaucucuagaagccacaugaagagagaagaaccuuuaaucccagcauuugggagacagaggcaggcagauuucagagu


 


ucgaggccagccuggucuacagagugaguuccaggacauccagggcuacacagagaaacccugucucggaaaaaaaguuuua


 


gcuuauccucugaccacauguguaucgugacaugcuugaagcuuaccuaucucuuaaaugaauucuugaucccuauauuuu


 


gaguuucagaauuuggauuuuaaguguuuguuucuuaguugugcugaaaauugaacgugggcuuuucacaugcuaggcaa


 


auuuguuggguuuuuuuguuuguuuuuuucucaagacaggguuuuucuguguagcccuggcuguccuggagaccaagcua


 


gccuugaacucagaaaucugccugccucccaagugcugggauuaaaggcgugagucaccacugcccugcuaggcaaucacuc


 


uuaaaacugcuacauauccucuguccccuuuugcucauuuuacaagguugcugugugcucaaucugcagucuauguuauau


 


gcuuacuggaucuaggcuuuugauguagaaugaaccauaugagugaugagguaucuuagagauggaaacuaagucuaaaua


 


gacuuguuccauauacaacuuaauacauauggucuaaggaacaugauauacauguaaacaaguaggaaggagauaagucugg


 


uguccagggaagccaggagagccucaucugaaacuggacagggguuugugagucaucaggugacaauugaacauaggguacu


 


cuucaugcaaaugguuaguaaccauugagccaccucuccaucccuuuauaccauuuuuuuuuuuagcauauauccuuguac


 


uuuauaggaauuauuugcuuuauucucuugugacuuguaaauugauguacuuaauuaaaucuuuuuccaacauaguucga


 


gcugcaagaacacuucuagccaaaaaccucucuuucaacaucacugaggaugaauuaaaggaaguguuugaagacgccaugg


 


agaucagauuagucagccaggaugggaaaaguaaaggguaguuuugugucuuugaguguuaaaguuuuauuaaguuuagu


 


gucuucuuccccucuccuuguccuugcagucucuagucugcugcuucaaacuuaacuucauaaccagaaaauugaauaucu


 


gguccucuggccucuaccucccaaguucugacauuaaaaaugcucaacugauggguuuugaaggugugaucaauuuucag


 


gcucaauccaaauuggcaucuuuugccacaaguacuauccuucccuauuuuaugagagaaaugugauucuaggcaguucag


 


ucuauuguguuggcucuuuuuccuccucaccaguuuaaaggaugaagaugagcuaauacauaguaaaagaacaguaaaagca


 


caugugacuaaguccuucaugucugaugcuugaguaauauuuucucuaacguaguaacugaauugucuuguacucuuucag


 


gauugcuuauauugaauuuaagucugaagcugaugcagagaaaaauuuggaagaaaagcagggggcagaaauugauggacg


 


aucuguuucacucuacuauacuggagagaaaggucaaaggcaagagagaacuggaaagaccagcacuuggagugguaaguua


 


aaggguuuauuguguagugggaacaggaaucauuuguaucuuuguauuuuaaguaauugguuaccuacaauuaguucacc


 


uuuguucauauagcugauguuuagucuucaugagugaaagcuauuugaaaucauuuccuuuggaguauaguaggcaaauaa


 


agcuuuuuguuggguauguuuuguacuuuaaauggcuuaaacuauuuuagaaaauaguguaagacaacaaagaacaguuau


 


cuaauuagaaugaaaaugaaaggagcaaagaaggcauuacuguauauaauggauauacacuggugguucuagaauuauggu


 


auaugguacaugguugaagugccauuguuucaguuaacauuccaguaaccuuguggauuagguuggagacaugcuuuauag


 


gugacccacuuacugaguguuuaaauauacacagacauacucuaacauaccuugcuaauguguuaucuuuguauuugcagg


 


ugaaucaaagacuuugguuuuaaguaaccuuuccuacagugcaacaaaagaaacucuugaggaaguauuugagaaagcaacu


 


uuuaucaaagugccccagaacccacauggcaaaccuaaaggguaaaauaauuuuuacguuagaugugggcuggacauacaua


 


cucuuacguauaagaguaagacuguccuguuagcuuaaaaaaaaacuaaaguuuuagcuauacaaagggcaguaaauauuga


 


uaguaaauuacaugcugaugccaaguguuucuaagcuuuauucugagaacugacuuucaaccuucagguaugcauuuauag


 


aauuugcuucauuugaagaugcuaaagaagcuuuaaauuccuguaauaaaauggaaauugagggcagaacaaucaggcugga


 


guugcaaggauccaauucgagaagucguaaguccuuugacaugauaugacuugguugggugauuuuuuuuuuuauuuuua


 


ugugccuauaugcucauuuggggcugucuuuauguuguugcugagaaaaugacaacuggauaugaugacugauuaccuga


 


gaaauaauugaugaaaucucaagaaaauuccucuagauagucaaguucugauccagcuaugucaacucaaagcagcaaccuu


 


gauugcccucugaguacgcuuuuuuuuugauccaguguagucuuuuuuuuuuuaaccuuaauuucuuguguuaauugcuu


 


uuucugguaaaagggggaaaaaaagacauaacaaaaucaguguaagggaaggcucagugguugagcacugagaggaccuggg


 


uucaaaucccagcacucacauggcaccuaucgagacaggauuucucuguguaguccugccugucguggaacucacucuguag


 


accaggcuggccucaaacucagaaaucugccugccucugccuccuaggugcugggauuaaaggugugcgccaccacugccca


 


acccugucuguaacucuuaagaucugacauagauugcagacaaaacacuaaugcacauaaaaaaauuuuuuuuuuuaaaaaa


 


ggaaucuacuucagcugaauguggcaguauggcaguauucaccaaggguucauagugaaacaggaauuuuucucuuccaga


 


accauccaaaacucuguuugucaaaggucugucugaggauaccacugaagagaccuuaaaagaaucauuugagggcucuguu


 


cgugcaagaauagucacugaucgggaaacugguucuuccaaaggguaagaaggcguaguaguguugcugcuuuuuagugaa


 


uucugcauggagaacuugggucugcaguaucuucucauugagcuccuuucuguccaucagugauagauuauggauucgcac


 


gagaagaagagagaauucacagaacuggcacuuaucuucuguuuuugcagaaguauauuuggcuguugugugagacauuau


 


gagauacuggcgauuuucucgaccugaagaguacuuuggucacucuacuugggugacuugguacuuauuguguuacuuua


 


aaauguguuuacuuaaugggugagguuuuuuuguuuuucuuuucuguuuuagguuugguuuuguagacuuuaauaguga


 


ggaagaugccaaagcugccaaggaggccauggaagauggagaaauugacggaaacaaaguuaccuuggacugggccaaaccu


 


aagggugaagguggcuuugguggucgagguggaggcagaggagguuucggaggcagagguggaggcagagguggaagagg


 


uggauuuggaggaagaggccggggaggcuuuggagguaaggaagggaaaggaacuggaaacggauuccuaaaccugugucc


 


uaaccaaccaccuuaaugggaaggucaguccuaauuguaucacccuuugauguuuuuccuuccuauagguagaggaggcu


 


uccgaggcggcagaggaggagggggagacuucaagccacaaggaaagaagacgaaguuugaauag


 









85
X57800
Sequence below.







uuagacgguugcgcgcgcagaggguugguaguugucgcuguaggccuucgcugccgcuucugcaucgugaaucgggggac


 


cuuggcagccagaccucguuccucuuagaguagcucucaucuagucgccacaacuccgccaccauguuugaggcacgccuga


 


uccagggcuccauccugaagaaggugcuggaggcucucaaagaccucaucaaugaggccugcugggacgucagcucgggcgg


 


cgugaaccugcagagcauggacucgucucacgucuccuugguacagcuuacucugcgcuccgaaggcuucgacacauaccgc


 


ugcgaccgcaaccuagccaugggcgugaaccucaccaggugagcggguggcgggagcggggccccacucuucccgcuuccgc


 


ucuuggcggggcugugacucugcacgcucauuggcuggcuuggccauccgcgcuuucugauuggucuauggugucggggg


 


cagcccucaccaaagcgcgcgguuccgaaaagcccgcgcuggcaguggcgcccacucuguuuccgcgccaaagccacaaagcg


 


ggaguccgcgggaaaaugagugcuccggagcugugcucauuaaaugccugcagcuuugaguggcuggucuuagcgccuaau


 


aaacgagucuuagugcaaauguaaugucgacuuagagugacaauagaccuuuucuugacuuccagagucucacugcgcauca


 


uggauuugaggggaaucugucaguuuuagcuuuuaacuuugcuacagcuaccuagguuagugccuccuguauacguguu


 


caaggacagugugugacuuauuuuaguacagauacauggauuagugccacuuguauacauuuugaaagauuuacgaaaagg


 


ccagacgugauggggcacauucuccaguacacuagaaaccaaggacaccccgcucaaaaagaugcuuucucgaauguuggcu


 


uuuagugcauuuuacuaagucgguuuuaagaaucacauauacccgguaauuugcuucaccccugagagaguuugggguacc


 


cuuagccccuuuaacaguucuccaaccgugagugugaaaugguacaacuuguaauugcuuuuuaaaauauagauguggauu


 


acauguugauaaagccugucuuuuuuuuuuugggggguagcauguccaaaauucuaaaaugugcugguaaugaagacauca


 


uuacauuaagggcugaagauaaugcagacaccuuagcacuaguauucgaagcaccaaguaaguuaaacaccuuuaaaacucg


 


gaguuacguguuguuucuguuucucaaaaccaaaaaaaauauuaacaauauuguaaauuccaucauagauaggaccgugug


 


gugugcuugguaacauuuuccuucuuuugguagaucaagagaaaguuucagacuaugaaaugaaguuaauggacuuagaug


 


uggagcaacuuggaaucccagugaguuaccuuguuucugauuguguguuacccugcugugauaccagcugaugcguguuc


 


ugaguggaguggugguauuggggaugaauggcacacugccauuucacuaaaccacagcagucuaaaguugauugaguuuua


 


aagaaaccagaagucuugcauucugaguucugguuaagaugcuaaaucuugagaacaugaagcugagccuucccccuuuucu


 


agacugaccuuuaacuuguggguuuacaggaacaggaguacagcuguguaauaaagaugccgucgggugaauuugcacgua


 


uaugccgagaccuuagccacauuggagaugcuguugugauauccugugcaaagaauggggugaaguuuucugcaaguggag


 


agcuuggcaaugggaacauuaaguugucacaaacaaguaauguggauaaagaagaggaggcggugaguaguaagggggcgu


 


ccaguuaggugucugaagcagggauggagccucggcuuuuguuuuuauuuauucauucauuuugagauggagucuugagu


 


agaccaagcuaucuuagagcucagagacgacuccauaagcuuuuacagguagcauuuggaaagcuaaguguacagccuuuug


 


cuuccuggaaauacucuuggcaaauaagugaggguuggcaagugagcaaaagaaaaugguuggggguguauguagcuuuau


 


guguugcagguucaagaguauuugcagucccaagggaaauaagaaagacuucacaaaauguggaaagaguuguauuaaaugc


 


ucuugacaguuacauccauagagaaagcugggcaugaugucucaaacccacaacugauguacucaaagcuacagcaggaaga


 


uucucagcuuaaagucaaccuggcagaaaaucuagcucaaaagaaugaggaagaaauugggaaggcaaaggaagauguucu


 


ccgaguccuccucauucaaguagaacauacuaggccucuuuaauuucuaaguaucccugaaucgaggcuuuuucucaggaau


 


ccaauguauauuucauggcuacacuuuuuuuuuucuuuuuuaaguuuugcuagcuagccugagcaucagaauuacacacag


 


aagucugaacuaaauaggauuuuuaggguuuaguauagugaaauucagagugcuucugcaaguauuuaagguaaauauaag


 


guguuacuuggccucugcaugaauuuaaaguaaaugaaaguguaagaauucgaacauagauaaacacacaacccaagaacua


 


guucuuaaccuuaaucugcugaauuauuucuacuuccauaucaacuucagcuccucaguucucaaauacugacauguaauuc


 


aucaguauuugucugaugugcaagcauuuccacaacaaaagaaauuaaggaauuuuucaguauccacauguucaaggauugg


 


gaauugaauaaaauugauaaucauacaaugaagacugguuuacugucccuuagcuugcauucagcuguugguucuuguuuu


 


uggaagugguuauguguuaucuuccucucuucaugcauucuuugcaagagaaguauguacaaucugaauaggaacaacuuu


 


cuccuuuguuuugauugcuugggguguggcucuacaggaugggcaagcuagacuuuuuucuucuuuagucaagguuuuca


 


ucaacccuuccaaaaugauaacuauuuguuuugcuuugugguauaauaccgugaucuaauagugugaguuucugaugucua


 


cagugagccuguuuucuccucuagguaaccauagagaugaaugagccuguucaccuaacguuugcucugagguaccugaac


 


uuuuucacaaaagccacuccacugucuccuacaguaacacucaguaugucugcagaugugccccuugguaagaugauaaguu


 


ugaacauuguuuuguaaugugguauuuauaguauucggugguuuaauuuuuccugucuuucaguuguagaguauaaaauu


 


gcugacaugggacacuuaaaguauuauuuggcucccaagauugaagaugaggaagcaucuuaggcauugcuagaaauugag


 


aaaacuaaaccuuugaagauugcuccugagaugccagcguguccugaggucuuuucugucaccaaguuuguaccugaguau


 


ucuuaaauauuaauaaaauauguagauaucuucuguaaauaaccuacuuucuuuucucuccauucuccauaauuugcuu


 


aaagaauaagcuccaaaguaaaaacuaguuuuguuaacaugaauguuucugcuuuacaaauacuggugauuuuccaucaaug


 


aucuugacgcuaaaugcaguuuuaagaaauauuguucaauuuaaauaaaguuaacaauuugaaaaguca


 









86
M35247
Sequence below.







ggugcaggauguaggccugcagaauugucagacccaguggcggcuuuugccacuggaagaauuuccaacauaaaacaga


 


ugaucaguuugggacaaucgauucugcgaccagagguagugucauuugguuacuuuuaaaauucagauugucuggugu


 


uuuccaaucacucgcgacuguaauuugaaguuggguucugagauaauacaaucgcugucgcucuaguuuauaaagcugu


 


ccaagaucugcccagucccagauguccuggguccucagggccgcuguggucugccaacuucugcagcuggaugccagacc


 


auccuggacucggaucccuuuggguauuucuacaccgcugugucccggccuggccuuggggagcccugguucauaaucg


 


ucggcuauguggacgacaugcagguccugcgcuucagcagcaaggaggagacuccgaggauggcacccuggcuggagca


 


ggaggaagcaggugacugggagcagcagacucguauagucacaauucaaggacagcugucugaaaggaaucugaugaccc


 


ugguucauuuuuacaacaagagcauggacgacucucacacacuacaguggcugcaaggcugcgauguggagccagaucg


 


gcaccugugucucugguacaaccagcucgccuaugauagcgaggaucuccccacccugaacgaaaacccaaguuccugua


 


cagugggaaacagcacuguaccucacaucucucaggaccugaagagccacugcucagaucugcugcagaaauaccuggaa


 


aaagggaaggagaggcugcugcguucagacccuccaaaggcacaugugacccgucaccccagaccugaaggugaugucac


 


ccugagguguugggcccugggcuucuacccugcugacaucacccugaccuggcaguugaauggggaggagcugacccag


 


gacauggagcuuguggagaccaggccugcaggggauggaaccuuccagaagugggcagcugugguggugccucuuggga


 


aagagcagaguuacacaugccauguguaccaugaggggcugccugagccccucauccugagaugggagccugcauggua


 


ccaaaagccuuggauuuggauuguugccaugguuuucauuuuguucaucauuugucucugugugguuugcauaugcau


 


gaagaagaaugcaggugggagaggaaggcgugacacccaagaagcaggcagagacaguccccaagacucuagcaagacug


 


uuguggaugaugaggagauggggguuugcuuuuggaagauuaaguccuguaaaacuugucuaggccacuccccaggaac


 


uucaguuggcgagucuuuacugucaccuugacuggauuuaggaucaucugggagaugccccuuugaguggcugggcug


 


ugaggacagcaggccaguucuugccacccuggacagaaacacaucucaccuuucuggcucaaggaucugaacaccugucu


 


cuugccuacucggcuucuagucaggcauuuugucaccuugucaagggucccagggacacaaagcucccuccucucaccca


 


cagcacucuggguccuacccucagugcuucagggacauuuaaucaggucaaauugggaucaauggcuuugaugcagaaa


 


agaacuguggacuaauagagauaggguuuaauuaaaaaauauaucuuuuuaauuuu


 









87
AI553024
cuggcacggacauggcugucuucugucugcugugugggaaacgcuuucaggcacaaagcg




cacuccagcagcacauggagguccacgcaggcgugcgcagcuauauuugcagugagugca




accgcaccuuccccagccacacggcucucaagcgccaccuucgcucacauacagguuuuu




uucuccaugugucaccaagugaaguuugugccuucuauagcaaagagaauauuuuuuaca




uccuacuaacaguagauuuuuuuguagugaacauuuuuuguauuuuuauuuauaagucuc




auaagaaaaauagcgauguucaguuguauaccuugaaucugcaguuagaagagaauaaag




uuaacuc


 


88
X16995
Sequence below.







ggagccccagugcaggaggcugcgaaaguugggggagugugcuagaaggacugcggagcggagcgcacgcgggaccaggcu


 


gcgacugggucgcuggucccggccacagggagugggagccggcuggguagguaccccgcagggagcguguuucuguuucua


 


gggacagugcaugaaagagaugggguguacgcgcgggcgaaaaggaaggguguuuucgggucggcuuacgaggaggggug


 


uguagggugcauuuuugguauuaaaggauagcucuuggaguagggugagccagggcuugaaguuuaggaagcgggcgaag


 


ggucugcaaggugcuugguuuugguagguagugggcgcuuguuuaggagguuuccccgcuaggaucuccagugugaggca


 


cucuguacucuggguuuggguguugauugccggguaggggguugucugagcauggacugggaaaagguacucagagcuuc


 


ggcguugcuggggauccauccaaguacaaguaagauuggauuuccacgggucuccuucccggcucucagcccccuuucccag


 


uguuuacuuaauacuucauaggcuguacuuagauuuucugauucccuuaccgaacuuucuuucugaaccgugcuggaagac


 


cuggggguugcugaaggaaauggccagcuagguuggcuggguaaugguuguguuagacuaaguugucagaguaucuagaa


 


accuaggagcuguagccuggugcagcuacugaaagccgcacguggagccuggguggaaguugcucacgauagagucucgau


 


guaguacugacuaggggggagaccccuucugucaucagacagacuuguauaccccaguggucuuuugaaucuguuagguag


 


ggugcagccugcgggcuuggucaccuaacagguguugccaggaccugccccaagccggauucucccacucccucuuucaacc


 


ccgccucuuccuccuccuugagacacccccacccccucaggaggcuagaugcagaucuguaucuuguguugcugacuaucgg


 


ccugaagcuggguagauugguggggguugauccggauguaggauguccaaguggagaaacaggauuugaauggagcuggaa


 


caaacgcccaguccugacugcugccacccuucuuccuccacccccaacccaucccuucccaggcuucuugcaaacagaggcag


 


aaguggccauauuucuuucuuucucccaggugcuguaugcccuagggacuugacacggggcaggcggggugggaacugguu


 


ggggggggacgugcuguuuuaugggaagucguaugccuagccagcgguggagcuguccuggcuaggcacccagggguggu


 


guggggaaugggagaaauacugggacuagagggucucaagggccagcagguggugauagucuuuuucuccaccccacccuc


 


ugcuccaccaccccucugccucagcaccccucugcccucagcaccccucugccucagcacccucugccuccagccacccucug


 


ccucagcacccucugccucagcacccucugccucagcacccucugccucagcacccucugccucaguguuccugugugaccu


 


gucuuuucaacuagaaagucuagaacuguacagaccccagaguuggagguggaaagggacacuagguccuggagccuccucu


 


gugggcuuuuuugaccagaugagaacguaagggccuccuccagcuaucccuggucauucaggugcuucagguuugugaccu


 


uugcugagacccuggaugcugcagcaaacagacaucugcuuuagcagagggacagcuugucucugugcauccgcugguagg


 


auccuccacucuguccaauuagcuugcgcugcugcuggguucugaguguucucuuacaaaaugacaagguuagggggcugg


 


agagauggcucaggggcuaagagcacccauguggcaguuugcaacugucuguaacuccuguuccaggggggaucugacacc


 


cucacacggacaaacaugcaggcaaaacaccuauuggcauggaaaaugaaaauaaaugaccggguuagcugagaaauuccuuu


 


ugagaguugucuuuucuccaguccaggacugcucucuggaucuuccugcucaguuccucgccucccuuccauauaugguau


 


uuaagguuuuacuuuuuuuugcguuuucaauuguuuuuaauuguauuuauaugugucucugugugugcacaugagcaug


 


gguguccuacaaggcuagagacaucagauguccuggagcuagaguuacagaugguugugagccaccugauguaguugcugg


 


gaacuggauuuaguuccuguggaagagcagugcaugcucuuaaccacugagcaacuucuccacgcggcccccccccaguaua


 


cgguauuuaaaacucuauagcaaugcuacccaacccauuguggagcuggggauggugagguggccuaguuccccccaacucc


 


uggaaacaugucagaaaguacagagugggugccugugggaucagcaugcgggggguggugguggugagguguggggcugc


 


uuucucccgaggcuaccgugauagacaguuguaccuugcuggcagccucuaccccauuuccaggaugucagucucugcagac


 


guaugggggacgguggggaagggguauacagagccaugggugugccugggaauguacucccaggaagugacugguugaaaa


 


gucagcagaucuccugggggauagaggggugggcugaagcucuguggguugccucucucagcccugaccugugaacaggga


 


ggcuggggguuggaggaacacagcuucccccuguuccuggggggacaugcuggacagccuuuccuagcucccccggcccac


 


ugggguguggcuggucgucggacugagcucuuuuggaccuggucucugccugugagcuuugugacucguugagauagcau


 


uugggcugagggauugggagucuucuguucuuugguccugacacccgcuuccuugucuaggccugccaccuggcucccccc


 


accccccuccccggccuaccaaguuucuugcuucccuuacugaccccuccuccucccuccuuugugucuccucccucuccag


 


agaugcccuguauucaagcucaauauggaacaccagcaacgagcccaggaccgcgugaccaccugaccggugauccccuggcc


 


cuugaguucggcaagccuaccauggaccuggccagccccgagacagcaccugccgcaccugcuacacugcccagcuucagcac


 


cuucauggacggguacaccggagaguuugacaccuuccucuaccagcugccggggacgacccagccgugcuccucagcuugu


 


uccucugccuccuccacgucuucuuccucauccucggccaccucccccgcuucggcguccuucaaguuugaggacuuccagg


 


uguacggcugcuacccgggcacccugagcggcccauuagaugagacccuauccuccagcggcucugaguacuauggcagucc


 


cugcucagcccccucgccaucuacacccaacuuccagccgucccagcuuucucccugggacggcucauuuggccacuucuccc


 


cgagccagacuuaugaaggccucugggcauggacagagcaguugccuaaggcuucuucagggccuccgccaccuccaaccuu


 


cuucuccuucaguccucccacuggccccagccccagccuggcccagaguucucugaaauuguucccaccaccagccacccacc


 


agcuuggggagggggagagcuauuccaugccagcagcuuuccccggcuuggcacccaccucuccgaaccgugacacuuccgg


 


cauucuggacgcacccgugaccuccaccaagucccggagcggggcuucagguggcagcgagggccgcugugcagucugugg


 


ugacaaugcuucgugucagcacuaugggguccgcaccugugagggcugcaagggcuucuucaagguauuuuguugguucu


 


gggggacgaugauaucauguuggagguggggguggagugggucauccguugggaucuguagugaccucuccugagguuuc


 


uucccagcugguucuguccugcaggacgagggacaggugugugccaucuuagaggcugggacuuuuuauucagcagggcac


 


acaucucucuagggcugcagaaagcuggggaagggggcagaagguguguguguguguggccugcaguggugcucagaaaca


 


gaaaaccuagugggcagccucugguucuccacagaacuuguguuucuggcacuggaugaaaggacacaggcagaggguuug


 


guucuugcuggggguggacuugggaacaggcuguguguuugucccagugcugggugccugcuuggcnnnncccaccucca


 


nccccuuaguccucuccucugcgccaggaaaagggcagguggacacaugcagacaccuguuagaacaggugucuggacggcc


 


gugggaguuccuagacccuggucuuggguucugggaucuucccugugagguugaaaccuucuccaguaucucccagacucc


 


ucucugcgcucuggcccuccguuucucccucccccuacauccaaauguuaggaaaauagcuaugaacagagggcgcuuuugu


 


cugcgucggccacaggaucuggacgguccccuccccugggcucuccaccccccccccaaaccccaugcucugacagccuguuc


 


cguguccccccuuccuccagcgcacaguacagaaaagcgccaaguacaucugccuggcaaacaaggauugcccuguggacaag


 


aggcggcggaaccgcugccaguucugccgcuuccagaagugccuggcugugggcauggugaaggaagguggguggcaagau


 


ggugcccucggcauaggcgaccugauggggugggacagccgggcucaccaggaucugcaccuaauucccacucccacuucua


 


gauuccagccccuaaaugcagguguagcuuccaccugcuuucuggaaaggguggggugaggagggccuuguggggucccca


 


ucauggucugaguucucugucucugacuucucagaagugggguguauagugugcccugaagacccuccuucuccaggucuc


 


cuuucucaauacugcccgucucucugcaguuguacggacagacagccuaaaagggcggcggggccggcuaccuucaaaaccc


 


aagcagccuccagaugccuccccuaccaaucuucucacuucccucauccgggcacacuuggacuccgggccuagcacugccaa


 


auuggacuauuccaaggugaggucuugcccgcccaucugcccugcccugagaacauaugcaaugccuuugugccuguuagg


 


aaaggcucucccuccagggcaacaucaggaaacaagcauccucuauguacuggcuaguuggagaaaugcauugggaugggug


 


uggggucggggagccaguuacaaacagcugccguagcccuguuuuccugugggaauugacaagcacaugggcccagaauag


 


ggcucuuuugcacgccuggaucuggugucccagugcaugagagcucuguaaugcagcuuguguaggcuuugcuguggaccc


 


aaugcaggacacagcugugugaugcaggccuugcuguggagccagugcgugacacagcuguguggugcaggcccucaugug


 


gaacuuaccugcguuccuuucaguuccaggaacuggugcugccccgcuucgggaaggaagaugccggugacgugcaacaau


 


uuuaugacuugcucucugguucccuggacguuauccgaaagugggcagaaaaaaucccuggcuucauugagcuuugcccag


 


gagaccaagaccuguugcuagagucugccuuccuggaacucuucauccuccgccuggcauaccgguaagcugcccaccaucc


 


uccuagcccuggccccagcccugcggccccggccugccuggacccugaguccugacuguucucugccuucugccagaucuaa


 


acccggugaggggaagcucaucuucugcucaggccugguacuacaccagcugcagugugcccguggcuuuggugauuggau


 


ugacaacauccuggccuucucacggucccugcacagcuuggguguugauguucccgccuuugccugccuguccgcucuggu


 


ccucaucacuggugaguggcagaaacuagacugggcccaaggguugcaggaccauuggguagguagcaucuaacacuuugg


 


ggaccccuagagugccugcaacauugggauguuaggaccugcaaagggacuuagcucuauucgccccuaaagcuuaaaucag


 


ccuccgaaugaccccggacuccucagguacgacuguaggcgcugggcaucuagcuuagggauucuguuuguuuaaaaaccu


 


agcugucaaccucacaagacacaggaacgugcacacaugaauuuuucacauucugcgcuuggauagcuaucgccauggucca


 


gaaacaggaccuacuucagcucuguugggcucccuccuuauugucucuguaagagguaaccacucugccagccucaguggca


 


uuccugucauggauuuuacugugcguaucacaggguauggacucuaguguuaaauguagagguuucugggucccuucucg


 


uuccgcucccauuuccacuuaaauuucuuaggggauccuccugaguagaucaagaccaggagcuggaucuugaaaggguag


 


ggagugauaucuacacccagcucaguccuuagucuguccugcgagacuccaggauuuuagaacaguguggagccuggaccuc


 


cagaaaaccuggauuaggcuuuugccuuggccagccauucagugguuucaaauauugaccagucuggacagugggcuccug


 


ugggacgugcuagagggcuggggaagcuugucagggagaaggcgucaacugagcggggcugacucuaccuucccugcugca


 


gaucgacacgggcuccaggacccucgucggguggaagagcugcagaaucgcauugcuagcugucugaaggagcacauggcua


 


ccguggcaggagacccacagccggccagcugccugucacgucugcugggcaaacugccugagcuucggacccugugcacuca


 


aggccugcagcgcaucuuuugccucaaguuggaggacuugguacccccuccaccuauuguggacaagaucuuuauggacaca


 


uugucuuucugaccccugcccugaacaugugugcgcacacgugcgugcucuucugucacccaugugccuuuaagccuauag


 


cccacggacccccagaccacccuacccccagccugguuuugagcuaagacugacguaccuccucacuccagaagauggacaga


 


gaacucaagaccugggggaggguguguauucacgggggugaccccacuauuugucuuaucccuccagcucaguccuggccu


 


ucguguguuuuuguaagauaaaccauuuuuaacacauaccacucuguuguaaauaagcugacgcuacuguaaauacagaaag


 


gaagagguugagauggggguugggaggaagggguggggcucccaccagcugggcgagccuccaacucgagaucucuuccgc


 


ucuccuuccauguguacauaacugucacucaagaaggugauugacagauucugauuuauauuuguguauuuuccuggauuu


 


auaggaugugacuuuucugauuaauauauuuaauauauugaauaaaaaauagacauguaguugaaa


 









89
AF038562
ggcacgaggcugugcccgccaugucugcuacccaucacaagaccucccugccucagggcg




uccgcgugggcacugucaugagaauucgaggcuuggucccugaccaggcuggcagguucc




auguaaaccugcuaugcggugaggagcaaggagcagaugccgccuugcacuuuaacccga




ggcuggacacuuccgagguugucuucaacaccaaacaacaaggcaaauggggccgugagg




agcgaggcaccggcauccccuuccagcgugggcagcccuuugaagugcuccucaucgcca




cagaggaggcuucaaggcuguggucggggaugacgaauaucuccacuuccaccaccggc




ugccgcccgcccgcguucgcuugguggaagugggcggagacgugcagcugcauucauuga




auaucuucuaagcaaaggacccaagggccuuugcccgguuacggguuggggguuuuuuga




ucccacaagaaagguuuuggaucggccaauaacauuuuucuguuguucugaaaaauuaaa




aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa


 


90
Y11666
gccacauuguugcaccaacuccagugcuggagucucaggacaccaca




ggcuacccggaguuguucugcuuuggagauccgagggcaggagcaucacgccagugacuc




ugauaggugcgaucgccggauuggaacagaacugucauuuuuuuccgaaguugagccuua




gugacccagugagugaaguuagcgacgggacgcuaagcagcuagaccggucggcaggagu




gagacuuaggguaccuucuaguaguugugauuaaaaaaauugaaaaaaagaaaaaaaaaa




acccuguuucuggaaacuugaggcccucagcuggugagccaucgugguuaagcuucuuug




uguggcuccuggagucuucgaucccagccggacacccgggccugguuucaaagcggucgg




acagcgcugccugcuccaucgguagcgcucgagccucgguuucucuauuuggccccgacu




cgccgcaacaagaugaucgccucgcauaugaucgccugcuuauucacggagcucaaccaa




aaccaagugcaga


 


91
U40930
Sequence below.







cccagcuguuucguccguaccuagaccgcgguuauggcgucguucacggugaaggccuaucuucugggcggaggagg


 


cgacccgcgagauccgccgcuucagcuucugcuucagcccggagccggaggcggaagcccaagccgcggccggcccgggg


 


cccugcgagaggcugcugagccgaguggcugugcuguuccccacgcugaggccuggcggcuuccaggcgcacuaccgcg


 


augaggauggggacuugguugccuuuuccagugaugaggagcugacaauggcuauguccuaugugaaagaugacaucu


 


uccgcaucuacauuaaagagaagaaggagugccggcgggaacaucgcccaccaugugcucaggaggcaccccgaaacaug


 


gugcacccaaugugaucugugaugguugcaacgggccuguggugggaacucgcuauaagugcagugugugcccagacu


 


acgaccugugcagcgugugcgaggggaagggccugcacagggaacacagcaagcucaucuuucccaaccccuuuggccac


 


cucucugauagcuucucucauagccgcuggcuucggaagcugaaacauggacacuuuggcuggccuggcugggagaugg


 


gcccaccggggaacuggagcccacguccuccucgugcaggggauggccgcccuugcccuacagcugagucagcuucugcu


 


ccaccagaagaucccaaugucaauuuccugaagaaugugggggagaguguggcagcugcccucagcccucuaggcauuga


 


gguugacauugauguggaacauggagggaagagaagccgccugacacccacuaccccagaaaguuccagcacaggcacag


 


aagacaagaguaacacucagccaagcagcugcucuucggaagucagcaaaccugacggggcuggggagggcccugucag


 


ucucugacagagcaaaugaaaaagauagccuuggagucggugggacagccagaggaacagauggagucgggaaacugcuc


 


aggaggagacgaugacuggacacauuugucuucaaaagaaguggacccaucuacaggugaacuccagucucuacagaugc


 


cagaaucggaagggccaagcucucuagaccccucacaggaaggacccacagggcugaaggaagcugcccuauacccacauc


 


ucccaccagaggcugauccccggcugauugagcccucucccagaugcuguccauggguuucucggaugaaggcggcug


 


gcucaccaggcuccuacagaccagaauuacgacaucggggcugcucuggacacgauccaguauucgaagcacccuccacc


 


auugugauagugcuguggccaagccccacccccuuugucuuguaguugcaucacguagagcagcagggcuucuauagau


 


aggcccagugucuuggcauucuuguagaaucuucaggugggaaugugugaugccuuuucaggcaauaggaaagugcau


 


gaggagaguuuugaaugugcauaugcugacgccugagaacagacccagguacccguggcugagcugagcuuccucugcu


 


uccccuaggccuggccucugcagggaacugcagcacacacugcacucccaccugcucuugccgccagcauugcaccagca


 


guccagaauuccugccgacaacccguguuuccuuuauuaaaagugauuaguacaacugcuaguuauuuucaacaaaua


 


aagccauuauguuaagaggggacuguccauagugagugaaagguggcaggcaggggccuacagcuccuagggaauggag


 


aauucaugugaagccgaaugaaggaucuuaucuuauacugucccccuuucuaauggccacucuuuaguguuugugucua


 


auguuaaugcuuaaagcacaggacccccauguagcuuccucugacuugguuuguaaguaaccuguaauaaaaugccaua


 


ugcacuuuaacca


 









92
D26090
Sequence below.







gagggaauugcgggaccccgucuggggaagcucccgccgccccggggugcucagcucucugucucccuugacccaggua


 


cagucaugucgggcuucgacgacccgggcauuuucuacagcgacagcuucgguggcgaccccggugcggaagagggcca


 


ggcccgcaagucgcaacugcagaggcgauucaaggaguuccugagacaguaccgagugggcaccgaucgcacgggcuuca


 


ccuucaaguacagagaugaacucaagcggcauuacaaccugggugaauacuggaucgagguggagauggaggaccuggcc


 


aguuuugacgaggaacuggcugaccacuugcauaaacagccggccgagcacuuacagcugcuugaggaagcugccaagga


 


gguggcagaugaggugacccggccccggccagcuggagaugagcugcuccaagacauccaggucaugcucaagucagaug


 


ccagcccgucgagcauucggauucugaagucagacaugaugucacaccuggugaagaucccuggcaucaucauuucagcc


 


ucugcaguccgugccaaggcuacucguaucuccauucagugccgcagcugccacaacacccucaccaauaucgccaugcc


 


caggccuagagggcuaugccuucccaggaagugcaauauggaucaggcugggcgcccaaagugcccacuggauccauacu


 


ucaucaugccugacaagugcaaguguguggacuuccagacucugaaacugcaggagcugccugaugcagucccucaugg


 


ugagaugcccaggcacaugcagcuuuauugugacagguaccugugugacaagguuguuccugggaacagggucaccauc


 


augggcauuuauuccaucaagaaguuuggcuugaaccccagcaagggccgggacaggguaggugugggcauccggagcu


 


cguacauccgagugcugggcauccagguggacacagauggcucuggccgaagcuuugcugggucugucagcccacagga


 


agaggaggaauuucgucgccuggcugcccuccccaacauauaugagcucaucuccaagagcauuucccccuccaucuuug


 


ggggcauggauaugaagaaggccauugccugccugcuuuuuggggguucccggaagaggcucccagauggacucacucg


 


ccgaggugauaucaacuugcugauguugggagacccugguacagccaagucucagcuucugaaguuuguggagaagugc


 


ucucccauugggguguacacaucugggaaagguagcagugcugcaggcuugacugccucagugauacgggaccccucau


 


cucgaaacuucaucauggaagguggagccaugguucuggccgauggugggguugucuguauugaugaguuugacaaga


 


ugcgggaagaugaccguguugcaauccaugaggcuauggagcagcagaccaucuccauugcuaaagcugggaucacuacc


 


accuugaacucucgcugcucuguucuggcugcagccaacucaguguuuggccgaugggaugagacaaaaggggaggaca


 


auauugacuucaugccuaccaucuugucccgauuugauaugaucuucaucgucaaagaugagcacaaugaggagaggga


 


caugaugcuagccaaacaugugaugacucugcaugugagugcacugacacagacacaggcuguggagggugagaucgac


 


cuggccaagaugaagaaguucauugccuacugccgagcgagguguggaccucggcuaucagcagaggcagcagagaagcu


 


gaagaaccgcuacaucaucaugcggaguggggcucgucagcaugagagggacagugaccggcguuccagcauccccauca


 


cugugcggcagcuggaggcuauugugcgcauugcugaggcccucaguaagaugaaacugcagcccuuugccacugaggc


 


ugauguagaggaggcauugagacuguuccagguguccacacuggaugcugcuuugucuggcaaucugucgggggugga


 


gggcuucacuacccaggaggaccaggagaugcugagccgcauugagaagcaacucaagcgccguuuugccauuggcucuc


 


aggugucugaacacagcauuguccaggacuucaccaaacagaaauauccagagcacgcuauccgaaaggugcugcagcuc


 


augcuacgcaggggugagauccaacaccguaugcagcgcaaggugcucuaucgccucaagugagcccauugcccaucaac


 


ccucaagccugaaaugcugccaccacccuaucucccagucagugcuccaaaccuccuuuugcccugccucuccaccucaga


 


cugcugucugcagcacaucugcagccccuggaaauguacuuuggucuguuggcucauacuguguuugagugucugagg


 


acucucugcucugggugucuauccccugucaugccuucucaacaagaugagucuggagcaggaacaggcccuggaaugu


 


agaugggucuguauauuggcucccgggccacucacugccaagcuucuuuguauguacagagguaauaaagcaauugagu


 


cccuggcugcuaaggucaguggacccagu


 









93
AI787627
ggaugcagccggaagugcagcgugcgugcgguuuggugggucgcugugugcgcuccgcgu




gugcagccgcgugggccauggggcggcgggcgcggggccggcgguuccagcagccgccgc




agccugagggcgaggaagacgccagcgacggcggcagaaagcgaggccaggcgggcuggg




aagguggcuaucccgagaucguaaaggagaacaagcucuucgagcacuacuaucaggaac




ucaagaucgugccagagggagaaugggaccaauucauggagucacuccgagaaccucucc




cagccacacugagaaucacuggguacaaaagccaugccaaagagauucuccauugcuuga




agaacaaguacuuuaaggaguuggagganccugaaguagauggacagaaaguugaguucc




acaaccacuaagcugguacccugaagaacu


 


94
M33988
gagcucaaauucuggcuuucuauuggguacgauauauuaaccaaugggagaaacacaaac




agaauaccuccaguuaguauaaaugcuugcuguucaguugcagaauuuacuauauauucu




uuuccuuucucugcuuugccuuuacugauacuuaaacgcauacaugucuggacgcggaaa




gcaagggugcaaggcccgcgcuaaggccaagacccgcuccucccgggccggccugcaguu




ccccgugggccgcgugcaccggcugcuccgcaagggcaacuacucggagcgcgugggcgc




cggcgccccgguguaccuggcggcugugcuggaguaccugacggccgagauccuggagcu




ggcgggcaaugcggcccgcgacaacaagaagacgcgcaucaucccgcgccaccugcagcu




ggccauccgcaacgacgaggagcucaacaagcugcugggccgcgugaccaucgcgcaggg




cggcguccugcccaacauccaggccgugcugcugcccaagaagaccgagagccaccacaa




ggccaaggggaaguaaucuggcgauugucuguacugcccaguugaaaguuaaccaaaaca




aaggcucuuuucagagccacccacaucuuuccauaaaaugagcugccaccucgugaaacg




uucuuccacuacaguuuuuauacuacauaugaaaaaguuacgaaguagcuuucaaucuua




guaaauugauuuuaauacuguuagucccugcgauaaaucuuacgaccuuccuuaguuuga




gucaaaaguguguaagagaugaaaccuuuagaacauacuauaaauuuuuaguagaaauuu




ggcacccagguuugucauucacgucacgauugucuagagcauaaugguaguaagggcuaa




gggccauuaaaucccacuuccauaguuuc


 


95
AI845182
uuuuuuuuuuuuuuuuuggaaaugaagguaauuuauugaaacugguuuugggacaggcga




guggacaacuguugaaaggagcuagcgcacagccgggugggagcgggugcuuagccacag




auccuaucugaggcccaacuuuuucuuuuccuucugcuucuuacggaccacauccagguu




ccgguccuuccacaugcuuuugcgaagcuugauggggcgugagcccacauacuucccauu




caucucucgcauggcgcgcacauagucacuggggucuuugaagcugacaaagccauagcc




cuugguuuugccugugcgcuuguca


 


96
AA619207
uucggauccuugccaauauauguaucccauuuggaauggugaucuuaaaaugugagugca




ugcauacuaucuuauuuaagauacuugcaccccacccacucccaucucccgaagcuggaa




cacugccaacuagguccuuaagaaucacgcaauuaacacaagguugggugcugcuaauuc




uucaugaaaauccaaacacguuaagggaccagggagaugccacugccccccugaauuuuc




aucaaaaauagacacguuuauguaaacagaacuauuuuccauauucauagugacuuuuua




aguauuugagccuaaagauuuugaucuccauuuuuauaacuauuuaaauuguucacaauu




auuacau


 


97
AW125783
cggccgccgccgcccccacacugccccgcguugacgagcgccgcgacggcaaggacagcg




ccucgcuuuucgugguggcucggauccuagcggaccucaaccagcaggcgccggcgcccg




cccccgcggaacgcagagaaggggccgcugcgcgcaaggcgaggacccccugccgccugc




cgccugcgcccccugcgccgccacccggcccagagcccgccuccccgggacaagcaggcg




cgccggccgcgccccccagccccgcguggagcgagccggaggcggcauuggagcaggagc




ccggccccgcggggagcggcgagccuggccucagacaaaggggucggggaggccggagcc




gcgcggaccucgaguccccgcagaggaagcacaagugccacuacgcgggcugcgagaa


 


98
J04103
Sequence below.







cgucaguccccgccaccuccccggccccgcgcgcccggaucggcccuacggccucgucucgcccggccuugcgcgccgggacc


 


gccgcgaucuccucuccccgccgcccuccggcuggcccugccugcugcggcgcgaugaaugacuuuggaaucaagaacaugg


 


accaaguggccccugucgccaacaguuuucgugggacacucaagcgccagccagccuuugacaccuucgauggcucucuguu


 


ugcugugcucccuucucucagugaagaucagacacuccaagaagugcccacgggccuggauucugucucccaugacucggcc


 


agcugcgagcugccuuugcucacucccugcagcaaggcagugaugagccaagccuuaaaagccaccuucaguggcuuccaaa


 


aggagcaacgacgucuuggcauccccaaaaaccccuggcuguggagcgagcagcaggugugccaguggcuucucugggccac


 


caacgaguucagccuggugaaugugaaccugcaccaguuuggcaugaacggccagaugcuguguaaccucggcaaggagcgc


 


uuccuggagcuggcgccugacuuugugggugacauccucugggaacaucuagagcagaugaucaaagagaaccaagaaaaga


 


cagaagaccaauaugaggaaaacucucaccucaacgcgguuccucauuggaucaacagcaauacauuaggcuucagcauggaa


 


caggcuccauauggaaugcaggcaccaaacuaccccaaagacaaucuccuggacagcaugugcccgccaucggccacgccugc


 


agcucugggcucugagcuccagauguugcccaagucucggcucaacaccgucaaugucaauuacuguuccaucagccaggac


 


uuccccagcagcaacgugaauuugcucaacaacaauucuggaaaacccaaggaccacgacucuccagagaacgguggggacag


 


cuucgagagcuccgacucgcugcugagguccuggaacagccagucgucccuacuggauguacagcggguaccuuccuucgag


 


agcuuugaggaggacuguagccagucucugugccucaguaagcugaccauguccuucaaggacuacauccaagagaggagcg


 


acccagucgagcaaggcaaaccaguuauuccugcagcaguacuggcuggcuucacuggaagcggaccaauccaguuguggca


 


guuucuucuggagcuacucucugacaaguccugucaaucuuucaucagcuggacgggggauggaugggaguucaagcuugc


 


ugaccccgaugagguugcccgccggugggggaagaggaaaaauaaaccaaagaugaacuacgagaagcugagccggggcuua


 


cguuacuacuacgacaagaacaucauccacaagacuucgggcaagcgcuacguguaccguuucguaugugaccugcagaacu


 


ugcugggcuucacuccggaggaacugcaugccauccugggcguccagccugauacagaagacugagggccuca


 









99
D90146
Sequence below.







auggcucuaacaacgcugcucuuggugguggcggccgcccugacccugaucgagacccgcgcgggugagugcggggucggg


 


agggaaacagccccugugccgcguccccgcuucgcccaccggaccuccgccccuucuccacccgagccccgagcccugcucca


 


cucccggcccgcguacccgaccggggucccgggaggaggucggggucucaccgcgcgccgcccccaggcccacacucgcugc


 


gguauuuccacaccgcugugucccggcccggacucggggagccccgguucaucaucgucggcuacguggacgacacgcaguu


 


cgugcgcuucgacagagacgcggaaaauccgaggauggagccgcgggcgcgguggauggagcaggaggggccggaguauug


 


ggagcgggagacacagaucgccaagggccaugagcagaguuuccaagggagccugaggacugcacagagcuacuacaaccag


 


agcaagggcggugagugaccccgggucggaggucacuaccucuccacgucccgaaacagaggccggugaggucccgggugca


 


aaguccgagguucaggagcagaacugacccaggacuggauucccuuucaguuuggaggaguccgcgguggggggguggggg


 


gggggcggaggagggacugaccacugggucccgcaggcucucacacacuccaguggauguauggcugugacaugggguccg


 


acgggcgccuccuccgcggguaccugcaguucgccuaugaaggccgcgauuacaucgcccugaacgaagaccugaaaacgug


 


gacggcggcggacauggaggcacagaucacccgacgcaagugggagcaggcugguauugcagagagagaccgggccuaccug


 


gaggucgcgugaggcuccgcagauaccugcagcucgggaaggagacgcugcugcgcacaggugcaggggccgcgggcagcuc


 


cucccucugcccucaggcuggggcucaguccuggggaagaagaaacccucagcugggguggugccccuggcucagagggga


 


gagagugacccugggucuccugaucccucaucacagugacugcacugacucucccagggcucagccuucucccuggacagug


 


cccaggcugucucaggagggaaggagagaauuucccugagguaacaacagcugcucccuucaguuccccuguagccucuguc


 


agccauggccucucccaggccaggguucucagccuacacccacugucuguagacacugacuccuguccugcugaguguguca


 


gcccuuacaccucaugaccugaagucuccuuuacccgaugggagacauggacaucuacacuaggcugguucccccaguuucu


 


agaacuuuccaaagaauacagucuaccagauccuucccugucugugggguuugcauccuuugacacccaauucuaucuauuc


 


cugcaauggugaauagucacaugagccauuauggguuacccuaaacaaauacuuuucuuguguuuuuccccucucguuuuc


 


uuuuuaucuuuacuuuuuuuuuaaggguauuauguugcuuauaaucgguuuuucuucggcacuggaaugauauugcucuc


 


ucuccccaccauacccccacccccgccuauaucauuuguaucaguagcccuggcugucguggaacucacucuguagaccagg


 


cuggccuugaacucagaaaucagccugccucugucucugccucugccucccaagugcugggauuaaaggcuugggccaccac


 


cacugggcagaagaaagguuccugugagcuuaaaauguuuucuggcagaauuaaccauccagaucacuccugauaucccugu


 


gccccaccaaguuacagugcucccccuggugaaucagaacuuggacucugagagacagggucuucugcaauccaggccugag


 


ugagagggaagaccacacacccugugagcccacuguguuccagugagugcugcacugggguccacagcacauuccagggauc


 


cugugugacacaucuguaccuugucccccagagucaggggcugggagucauuuucucuggcugagugucagagguucacca


 


cauuucugcuacacacucccugauggcuguuuacuuggacugacaguuaauguuggucagcaagaugaccacagugguuua


 


gucucaauggugucacucuuccaguagcauaugguccugauuucuaauuuagauacgaacucaaacacauaugaaauuucu


 


uauuuuccauuccaucuuccauuauauagcuaccuaucucgugcuauugaacaucacauaaggaugaccauguugacccacu


 


ggcucauguggauucccucuuagcuucugaguccccucaggaaaaugugcaguccugugcugagggggccagcucugccug


 


caggucacuagugccaugacaguuaaaguguucauacagacacauaguucauuguaauuacugauuuagcguugucuuggc


 


aguuuucaguuugcaugcauuuauuuauuuauuuauuuauuuauuuauuuauuuaaugcauggaaguacacuguugcugu


 


acugaugguuguuugccuuugugugguuguugggaauugaauuuuuuuuuuuaggaccucucuuugcucuggucgaccc


 


ugcucacuccggucaacuccuaugggucaacucugcucauucagucccugcuuguucuggcccaaagauuuauuuauuauu


 


uauuauacauaaauacacuguagcugacuucagaugcaccagaagagggcgucagaucucauuacagaugguugugagccac


 


caugugguugcuggaguuugaacucaggaccuucaaaagagcagucagugcucuuacccucugagccaucuccccaguccuc


 


aguuugucuucuuaauugugcgauuucuugaaucuuccaaacagaucccccaaagacacaugugacccaucaccccauaucu


 


uaugaugcugucacccugaggugcugggcccugggcuucuacccuguugacaucacccugacuuggcaguugaauggggag


 


gagcugacccaggacacggagcuuguggagaccaggccugcaggggauggaaccuuccagaagugggcagcugugauggug


 


ccuuuuggggaggagcagaauuacacaugccaugugcaccaugaggggcugccugagccccucacccugagaugggguaagg


 


agggugugggugcagagcuguggucagggaaagcuggagcauucugcagacucugagcuggucagggcugagagcuggga


 


ucaugacccucaccuucauuuccuguaccuguccuucccagagccuccuccauacacugucuccaacauggcgaccauugcu


 


auugugguugaccuuggagcuguggccaucauuggagcugugguggcuuuugugaugaauaggaggugaaacacagguag


 


gaaagggcagggucugaguucucucucagucuccuuuagaagugugcucuaaucauuaaugggaaacccaucuacaccccac


 


auugcuaccuucuccaacuggguccucugucaguucugggaacuuccaagaucuuccuugaacucucacagcuuuccuucu


 


cacagguggacaaggaggggacugugcuccagcuccagguuaguguggggacaggauuguccuguggacauugcagugaag


 


cuggagauguuggggagcucugggaacccauaguaacucuuccagagaaaucuuccagggccgcaguuguccaauaugaaua


 


cauauauguacauaugcauauacauuuuuuacccuuggcagggacagcuccuagagcucugauagaucucucccagguggu


 


aaaggugacacucugggaccugauuggggaggggcaauguggauaugauuggguuucagggacuccacgaauccccucuga


 


gugagugguggguuguuggaauguugucuucacagugaugggucgugucccuc


 









100
AI563854
uuaaaucuggagggauuuuucacacagccuaucuuuuuaggugugccuuucccauauuuu




auuaaacucgaguuguuguuuuaaaaaaacagcagcauuaucaaagacacaucuguacaa




acauuuuacaaaagagaacucucuaggaucagcuacaucaaggacaagcagaaaaauaga




ugcaguccaacaaagacauugaaaaugacuu


 


101
AF017128
Sequence below.







ggucgcuuucugucuguagaggcggcuugccacccgagcagagggucgugaaguuccgaccggaccgguccacagaggu


 


ucaucuggagagguggguccccuccgaggugaaaggcgccgcugagaaacgcccccaccccccgugguucaagugguuca


 


gcccaagaacuuuucauucauaaaaaagaccagacuccgagaggcgcgagugagucagaaccgcagccgccaacgcggacc


 


cuaccgaacauccagcccagggcauguaccgagacuacggggaaccgggaccgagcuccggggcuggcagcccguacggu


 


cgccccgcgcagcccccgcaagcucaggcacagaccgcccagcagcaggugagacuggccgaaucgucgggggggggggg


 


accugaguuuggacagcaucagggaugcugggauuagucuaguuugcuccgggauuuggacuggggccccgagcagcau


 


cugacucugguggucgcgaccgaggauccugcacguucuguguggucggggaaccuauguacccgguggccaaggggac


 


gagcgcagcgggaagcgcgaauaucugcgaauuccccuucucgcucgcccguaucucccuagcugacugucuuucugccc


 


cuccgucuccguuacggucuuacauuuccuccuaucugccccuaauacgcugucccucuaaauaccugccccaucccugc


 


cuggacaggaucagagguguucuccaucuccaguuaauaacugggaccuggggucugggcacauagagacgggguccau


 


cagaacucagccgggacagagaauucuuagcagccuguccgaggcuguccguguguugcucugguuguccgugucccuu


 


uauccggucaaguccucaucucuuugugcgcaguauagagcccaugggccccaggcagugguuccgagggguuccugga


 


gaccacgaaguguugggaugugcgcggggucaccugcccggccacacucgcgcuccacauucucggcacccgacgucucu


 


cacugcuggauaggggcacuugagagguugcagguguccauuuccugucgaggggccgcgagcacgugucgccagggga


 


gggaaggagcugcguccguuucgccgagucacagcgggccgagucacugaggcugagucacccugggugccccucccuu


 


ccuggccccaaacggccccuaaggaccgacgaccugggagcgagagaugccccuggcagugcuucuagcccagaacgggg


 


gucacugagaugcugggucccccaguauugggcuggggacauagcuguccagacuugccuaagcaugugaggugcuucc


 


uggacuggagggcccccacauccuuagcucacagagcuugaacccaguuuucucucccagaacgcugagcccccaccccca


 


ccgacacucaaucccaacacaugccucagauuucugcaagaaaaggaaggaaaggaugccagaccccuuauaggaggcuuu


 


uacucucuucacuuuauuucauggacuuaaaaaaccccaucaauuuugaacuuucaaguuuuuaagucgacagcuaggca


 


ugcauuuaaucccagcauucaggaggcagaggcaggcagaucucugggaguuugaagccaauuuggucuacaaagugac


 


uuccaggucagcuagagcuacauaauagagauccugucucaaaacuuaaaaaauaaaaaacaaaaacaaaagccgauuaaa


 


acucugauuucugagcuaugagagcuggcuucucaacagcaauggaacguugaaugauguuaauaacagggaaacugag


 


acuaaauaacaugccccagucucaaagcccaucaauggccaagcuccaagcugaugcuggacucccaagcucuggugcuac


 


augucuauagucuuggugccugggagguagaggcagaggaaucgugaguuuaggucuagccugagcuaugugagaucc


 


ugcccaccccacccccggcccccaaacaacaaauucucauccugauucucagaauugccuugggagcuagaagcugaaagu


 


augcccaucugugaggacugggucucaaaucuuaguuucuacuuacuagcugugggucuaugggcaacugcucuccugu


 


cugaaaacaggauuauggcagcugugugagucacuauuuguuaaauaguuggaacaguguuacgcaguccauacuugau


 


uuaaaacaaaaaaccaaacuaucucugguggggaaacagacagacgaagagagacauuuugugaccugcccaaaaucacac


 


agcuccugaacaaguaaguuucugguugccaaauguugcuccuuguggucucccaaaacugguaucuacacugagguga


 


agggagacagaaguccagccucuguccccgggaagccccucaguccacacagaccuuaucauuucccuucuuaucucuca


 


gaaguuccaccuugugccaagcaucgacagcagcagccaggaacugcacuggauggugcagccucauuuccugggaccca


 


cuggcuauccccgaccucuggccuauccccaguacagucccccucagccccggccaggagucauacgagcccuagggccac


 


cuccgggggugcgucgcaggcccugcgagcagguaagaaacagcgauguuucacuuuccauagcccguagggguccuac


 


uagacagggacaggaucuugcuacgagggaauuucuuauucagcauugaaguuccugagaggccaagaaggagguaaaa


 


ggucaccuuugagucaaggaaggcuuccuggagaaggcuacacguuaaccuaaaccacggauaggauuugcguauggaa


 


gcugaaaagaaucuucugggaggaggguuggaggcacagaauugaggugaaggggacagaguguuaagugagcaugucu


 


ccacugucugacgugcacaggguggaaggaagccugaugcuggcuuuguaccucggggugacucuucuuuucaacaguc


 


acggaaucucagccuauuucuuuuaauuaucacaaaaagugagugggcagugguggcucacaccuuaaauuucagcacug


 


gggaggcagaggcagguggaucucuggguucaaggccagccugguuuacagagugaguuccaggacagccaaggcuaca


 


gagaaacccugucucaagaaagggaaaaaaaaagugaaugggaaauguauuucaauuuuuccaucuuccaucagaggaag


 


ugaagcauagagggguacucacuuguccagauucauacaaaugugaguaaugagacaggacugguccuggccugagguc


 


uacucaacucccaaagucagagcuuaaugagccacugucucaaugggagcucacagaagccugcagagggagugagcuga


 


gaacuuuugccucccugaaugccuuucuaaaauaaagaaggguguguuuugguugguuuguagagguggggucuugag


 


agccuccugccuucccaagugcuaggaguauagguguaugcuagauacccgacagggaugacggaucuuuuaggccaua


 


gcacuuucuuuccucucccugaaguacugagacugagucuagugcagggaggccuccauacuaaaaagcuggguguaccc


 


guaaucccagaacucggaaaaucaagacaggaggagccauucaagucacgcucagaaacauggagaguuuaaggucagcc


 


ugggauauauaaacccuaucuccgauaaccaaacaacaaucaaagcaaaccugacuuaaguguuaaguaggaaagaauaug


 


cuguaagucaucagccuggcugggggacugaccgccucugagggacugaagaaccugcuucaagcccggagcccugcacu


 


caaccccuaguggaugcacacacagauccuugccaugauggcucgaagagggauggcaagacccugggagauaugugaga


 


uuggccagagaagagccagcaacaggcuucccagcaagggaacagcuuaccucugugaucagcuggggcgugagcaagag


 


gcaagcccagggugaauccuuccuuuagcccuguccugaggagacaccuuuugaccacggguacuaguggguuggagcu


 


gugagcuguggguagguggcuuccccucggugugcucuggaacuugaacaaaucacucauccuuccugagcuuccucac


 


augugagugugcagagaucuggaugggugacucagcagcggcucuggcugcuccuuagaggauccggguuccaaucuca


 


gcacccacguggcaacucacuguccacaacgucccccaaagguucugaugcccucuucuggccuccaccagcacugaaugc


 


acaaggugcucauacaaacacacaggcaaaauacucagagguaaauuuguucuuuuuuuucuuuugagacaggguuucu


 


cuguauagcccuggcuguccuagaacucacucuacagaccaggcuggccucaaacucacagaggcaucugccugccuccc


 


aaguguugggaccaaagauguaugccaucacuauaagccuuuuuuuuuuuuguaaauuuuauuuaugaaugagugcuuc


 


cauguauaccuucaugccaggagagggcaucagauccuauuauaggugguugugagccaccguguguggcugggauuug


 


aacucaggaccucugaaagaggagcucuuaacugcuaaaacaucucucuagccccagucuacauauuuuaaaucuuuuuu


 


uaagauugauuuauuuauuauacauaaguacauuguagcugucuucagacacuccagaagagggcgucagaucuuguua


 


uggaugauugugagccaccaugugguugcugggauuugaacucaggaccuuuggaagaguagucaaugcucuuacccgc


 


ugagccaucucaccagccccuuuuuuaaucuuuaaaaaaaaaagggggggggccuggagagauggcucagccguuaagag


 


cacugaaugcuuuuccagagguccugaguucaauucccaacaaccacaugguagcucacaaccaucuguaaugggaucca


 


augcccucuucugguguaucugaagacagcaagggucuacucacauauguuaaauaaauaaauaaaaauuuaaaagccag


 


gugguguugguucagacagcagaucucuguuuaaggccagccuggucugaucuacaaaccaaguuccaggacagccagg


 


gcuacacagagaaacccucuaaaaaaccaaucuauguagggggugcuggugaaauggcuccguggguaaagguacuugcu


 


gcgaaauuaaugaccugaguucaauccuugaaauccacacaguagaaggagagaaccaaccuccaagggugcuaugacaca


 


cacacacacacacacacacacacacacacacacacacacacacacacgacuauauauaugaauauaugacucuagccaggca


 


uaguguggcacaugccuuuaaucacaguacuugggaggcagaggcaggugaaguuugaggccagccuacagagugaauu


 


ccaugacagcuagaacuaugaagaugaacccugucuuuaaaaacaacagcaacauaaagaaucuauguagggaagcuggaa


 


gggaugcugauacagucugcaauccuauuacucuagagguggaagccaaagaaucagggguuucaggccggucuugccu


 


auacacugagcuaaaggccagccugggacacaugagacuuugucucuuuuaaaaagacaaaacaaggggguugguuagau


 


ggcucaguggguaagagcacccaacugcucuucugcagguccgaaguucaaaucccagcaaccacaugguggcucacaac


 


caucuguaacgaaaucugagucccucuucuggagugucugaaaacaacuacaguguacuuacauauaauaaaaauaaaua


 


aaucuuaaaaaaaaaaaaaaaagacaaaacaagccagaugaggucugugaguuccaggccagccuggucuauaaaucaagu


 


ucaaggccaggcagggcuacucagagauucugucuaaaauacaaagaaacaaaacuacaaaaagcagaaaaaggaaucuac


 


gaaagggcuggugaagggguguaacucagugguagagcauuugccgagcuagcauguaccaagccauggguuugauccc


 


uagcacuaagcaaaagaaaaguccuacaaagggcuuuguuggcauaguagauugauucccaguagcuuuuggcacucaag


 


agcaccuucuacaauucacagcuccugggggaagaaaucccaucuuccacagaugaggaggcugagaguccugugaaaag


 


agauaaucaugucucauacacucaggagagaaggcuacuucugccugagaaaugaaaaggcuuccuggggucccaacauc


 


uuaguccaguccuaagaugcggaagggaggaagaucaaaguuuacagagagggaaagcauuucaggaaagaaaccagcag


 


uaaagcuaggugugugugagcuggaaaugucaccaaugagaugacaagcguccgguacagagaagcaacuguggagugu


 


ugggugguggcaccuagacuacagacugaaggaaagcuggaugaccagcucagggcagcugguggcucagagucagccu


 


cauugucucccuucuucuaucccaaccuagaucagcccagaggaggaagagcgccgcagggugagacgcgagcggaacaa


 


gcuagcagcugcuaagugcagaaaccgaagaaaggagcugacagacuuccugcaggcggugagcaucauccccaggcccg


 


gacccacagagccccaagaggggucucggcucccaagaacacaaaagacccaaaauuacuccucaggacucugucauccuc


 


ccugccuguggggaaguccuggaaaaaggauaagggaaaguggcuuaaauauuguuugucgggcuucgaggcagagucg


 


aagaugguaggcagcaauucuccuaagaugcccccgucugaugggagucauggccauuuucucccagaggcucacggga


 


gggaguugcaguccagacuuguuggggaugacaggcacagucccuacuccagccugaggcuuggggaucuuuagccuuc


 


auuuuccuaucuuucugcuaauccuguaaaggagaccgacaaauuggaggaugagaaaucggggcugcagcgagagauu


 


gaagagcugcagaagcagaaggaacgccuugagcuggugcuggaagcccaucgccccaucugcaaaaucccagaaggaga


 


caagaaggacccaggugguucuggcagcaccagcggugcuagcagcccaccagcccccggccgcccagugccuugcaucu


 


cccuuucuccaggacccguacuugaaccggaagcacugcauacccccacgcucaugaccacacccucucugacuccuuuua


 


cuccgagucugguuuucaccuauccuagcacaccagaaccuugcuccuccgcucaccgaaagaguagcagcagcaguggc


 


gaccccuccuccgacccccugggcucuccuacacuccuggcuuugugaggcacccagccacaucccuugcuggugcuacu


 


ccaagccauccccuuucucccauugauccagcaggccuggaccauacccuugccccaaaccagcagaucuuuuaucucuuc


 


cgacuagaacaaacacauuaugcuuugauguagagccagcuuggaggggauccccaaagcugcucacuguuuuucuagag


 


cuggccuaucauaauuugcacaaaauuagaggaaaauauguucccucugccagagaacgccuggcagcccagacuuugua


 


gauccccagggguccuuugacacccuuaccccuugcagaccacuuucccacaccacgucacuuucuucauguuauccagc


 


cuacucuacaccuagacagaaggugcccuuugacuagccuagaacacuaacucacacagcaucaacagccagcagcaccgg


 


acauccugcaggcuccuccugaauggcacaacgcaggaggcgccaggggcuucugugaggagcggagcugcacucccuag


 


cucugagaagcgcuuagcuucaggguauccgagccuccaccgcaagggcagcugcuauuuauuuuccuaaagagacuauuuuuaua


 


caaaccuuccaaaauggaauaaaaggcuug


 









102
X67644
Sequence below.







ccguggguuccuaauggugcuauugacgacgggcacaaagucucauaauuuuagaaacuucacuuauuuugugacccaccu


 


aguauggggcaaaggcaggagcuucggacuuccugucuucccucuaucccuuugaauagcgucucgggagugucccuaagu


 


aaccauugcaguuuuguguccgugugcucuguugaaaucucugugauguguguaugguuuucacgugaacggaggcaggc


 


agagcccggucuguggguucuaguguguucuuuaucuucuuggaaguuugugcaaugacuucccuccuguuuccugcgca


 


uaccuccaaguaaguacgugaauguguuuucuguggucccuugaucuugcuggacuucacuaaggaggguggcuggaccau


 


cugcuacgugucugagagccccucucuagcuaccucauguccggacgugagcuuacucccaauguuuuuacccacaagcauu


 


cacuacucccaggaaagaacgugcacuggggcaccuagagaauaaccaaucaacgcuccgccuacauuuugcuuccuccuug


 


gaauuuccagccccuugcagccaacugcuccccagcugcgaagggcggaguuccccccggcccggccccuucuuuggcucua


 


uaaguagcucugcuuugcgggggauuugcacuccucuacacucucugcacaacgucuaaauuaugugccacucgcgcaacca


 


ucuccacaccaugacuggccugagggccccuucuccagcucccuccaccggcccggaacuccggcggggcucuggucccgaa


 


auuuucaccuucgacccucucccggagcgggccgugguguccaccgcgcguuugaacacuucucgcgggcaccgaaaacgca


 


gccgaagggugcucuacccucgaguggugaguaucgcccgagugggcaucaggaggucgcgucgcccuggaacuuguaggu


 


aacaacuaggagcagggaccuucgaucugacguuucccucuuuuaucugcucagguccggcgccagcuaccaaccgaggaac


 


ccaacauugccaagaggguccucuuucuccuguucgccagcaucuucugccagauuuugauggcugaagagggugugucgc


 


agccccuggcuccggaggaugcuaccagcgccgugacaccugagcccauuucugcgcccauuacugcgcccccgguccucga


 


gccuuugaaccugaccucggaguccucggacuaugcgcuggaucuuaaagcuuuucucuagcaacauccggcggccuucuaa


 


acgcgaugggucacaguccgaagaaacaaaggcaccauggauggguaccuggugcgagagaacguaucccaaacugggauuu


 


cuaaggcaacgcuaacucagaacacuaccgccaagagacaccgcggguccuggcuaggcccacuggggacggacagagacuuu


 


cuccgugucuaauuaauauuuauguauuuauguauauccuccuaggugaaggagggguguauguaauauuuauucuaacu


 


uaugcaggggugcgagauaugccucccugcuguaacacagauauuuauuacgauuuauagggucgguaagacagaguugug


 


ggagggaggacccgggugguaggacucccagcuuggggauuagucuggggggguguaauaagauuagggguaacacuccg


 


ucuuccagcacuucaacucuguagucuguuguaaggcuuuggaagacccuugggaauccggccuuugaugucuucugguug


 


cuucucaggggcagcugcaggagucuuggguccauggauugucagagggcggcugucuggggucgccuaguauguauguu


 


cugugaacacgaauaaacuugauuugccugucauuauuaucugcaguucucgaaguguaucauucag


 









103
AF064088
See above (same Accession Number).


 


104
AI843085
uuuuuuuuuuuuuuuuuaaauugccgaauuaaguucuuuuaauagauugcauauauagau




guuuagccauacucuagaucaacucuuuaagaguagaauuuuauauccaauuuacaugcu




ucagauaucaccucuguuuguuacauaaggucuuguauccaaauguccacuuguacacug




agagcuuuaggaacaaaaaaggacacagagagaguugccauuuuuagcagcaaugaaaca




ucacuaaccccuuuuuacauaccgaauucaagucacuac


 


105
AW124932
cggccgccgguauuuuuuugcaaguauugagaguucuguauguuuugaaaagaguaauuu




uaacguuugggugccaagaaguggguuuucucagaguccauugccggcaaugggcaagcc




uggcgguacuccucgugccgaau


 


106
X58609
augg




cgcugggaacgcugcuccugcugcuggcggccgcccuggcccggacccagaaccgagccg




gugagugcagggucgggagggaaacagaacuuuccaaacagucugcggggaggggcgggu




gcggcaccggggaagccgcgugcccgcgucgcccaccagacccuccgucucuuuacccgc




gucccuagccccgcgcccugcuccccuccugucccgcgcauccgcccggggucccgggag




aaggucggggucucaccgcgcgccgcccccaggcucacacucgaugcgguauuucgagac




cgucgugucccggccgggccucggggagccccgguacgucucugucggcuacguggacga




cacggaguucgugcgcuucgacagcgacgcggagaaaccgagguaugagccgcgggcgcg




guggauggagcaggaggggccggaguauugggagcggaucacgcagaucgccaagggcca




ugagcagugguuccgagugagccugaggaaacugcuaggcuacuacaaccagagcgcggg




cggugagugaccccgggucggaggucaggccccuccacuucccgacacagggacgcugac




guccugguucccaagucugagguucgggaacagaacggacccgggaccgguuucccuuuc




aguuuggaggaguccgcgggugggcggggcugaccgcggggucccgcagguucucacaca




cuccaggagauguauggcugugaugugggaucggacgggcgccuccuccgcggguaccgg




caguccgccuaugauggcugcgauuacauugcccugaacgaagaccugaaaaccuggacu




gcgaaggauguggcagcgcugaucaccagacgcaagugggagcaggauggugcugcagag




uauuacaaggcuuacauggagggcgagugcgugcagucgcuccgcagauaccuggagcuc




gggaaggagacgcugcugcgcacag


 


107
M18837
Sequence below.







auggcgucaacaaugcugcuucugcugguggcagucgcccagacccugaucgagauccgcgcgggugaguaccggguccgg


 


agggaaauggccucugaggaaaggggagggggcggcacgggggaagccgcgucccggcgucgcccaccugacccuccgcccc


 


uucuccacccuagccccgcgcccugcuccccucccggcccgcucacccgcgggggucccggaaggaguucggggucucaccg


 


cgcccugccuccaggcccacacuugcugaguuauuucuacaccuccgugucccggccgggccuuggggagccccgguucauc


 


ucugucgguuacguggacaacacggaguucgugcgcuucgacagcgacgcggagaauccgagauaugagccgcgggcaccgu


 


ggauggagcaggaggggccggaguauugggagcgggaaacacagaaagccaagggcaaugagcagauuuuccgagugaaccu


 


gaggacccugcucagcuacuacaaccagagcgcgggcggugagugaccccggaucggaggucacgaccccuccacgucccaaa


 


acaggggcccgagacgucccgggccccaaguucgagguucugagcagaacggacgcgggacugguuucccuuucaguuugg


 


aggagccgcgggugggcggggccggggcgugugggcggggcugaccgcggggucccgcaggcucucacacuauucagguga


 


ucucuggcugugaagugggguccgacgggcgccuccuccgcggguaccagcaguucgccuacgacggccgcgauuacaucgc


 


ccugaacgaagaccugaaaacguggacggcggcggacauggcggcacagaucacccgacgcaagugggagcaggcuggugcu


 


acagagaaaagcaaggccuaccuggagggcgcgugcgugcagucccuccgcagauaccuggagcucgggaaggagacgcugc


 


ugcgcacaggugcaggggccgcgggcagcuccucccucugcccucgggcuggggcucaguccuggggaagaagaaacccuca


 


gcuggggugaugccccugucucagagggagagagugacccuggucuccugaucccucaucacagugacugcacugacucucc


 


cagggcucagccuucucccuggacagugcccaggcugucucaggagggaaggagagaauuucccugagguaacaacagcugc


 


ucccuucaguuccccuguagccucugucagccauggccucucccaggccggguucucagcccacugucuguagacacugacu


 


ccuguccugcugagugugucagcccuuacaccucaggaccagaagucgccuuuaacugaucggagacauggacuacccuaca


 


cuaggcugauugccucaguuuccugaauuuucaaaagaauacauucucccagaucccucccugucugugggguuuccacccc


 


uucgacaaccuaauucucucuauuccuauagugguggucacaucagcccuuaugggguacccuggaggaauaucaauagug


 


gaauuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucu


 


ucuucuucuucuucuuccuucucucucucucucucucucucucucucucucucucucucucucucucucucucucucucuc


 


ucuucuucaguuuuugagauaggguuucucuguaugcccuggcuguccuggaacucacuuguagaccaggauggccucgac


 


cucagaaauccgccugccucugccucccagugcugggauuaaaggcguguggccaccuugcccagccuuucuuauuuucuu


 


uacuuuuuuuuuuuuuuuuggaggggguaauuuuguuucuagucaucuuuugucuuuugucugcacuggagugauccug


 


uuucucccugcccuuauauuaucauguguaucagucuccacaggugccagggaaguuaagacaaguuaaaucaggguucuc


 


uuuaaaggagagauuccugugaacuuagacuguuuccugucagaacuaaacauccagaagccuccugcucuuccucuguccc


 


acaaguuacagugcuccccccccccccccagugaaucuggacuuggacucugagagacagggucuucugcaauccagggcug


 


gagugagagggaagaccacacacccugugagcccacuguguugcagugagugcugcacugggguccacagcauacuccaggg


 


auccugugugacacaccuguaccuugucccccagagucaggggcuggaagucauuuucucuggcugagugucagagguuga


 


caccauuucugcuacacacucugugauggcugcucacuuggacuggcgguuaugcuaguuagcaagaugaacacagugguu


 


uacgucucaguugucacacccuuccaguggcauauggcucuaauuucuacuuuugauacgaacucaaacacuuauuaaauua


 


guuaguuuccauuccaucuuccauucuaguccauucaugcuaaagaacaucacauaaggacugccaggaugacccacuggcu


 


cauguggauucccucuuagcuucugagucccccagaaaaugugcagcugaggaaaccagcucugccugcaggucaccagug


 


ccaugacaguugaagugucaaacagacacauuguucagugucaucagugauuuaacugugccuuguguagauuucagaggg


 


ucuuguuaauugugguacuuuuuuuuguuuuuuguuuuuuuuuuuuuuuguuuuguuuucaagacaggauuuuucugu


 


auagcccuggcuguccuggaacucacauuguggaccaggcugaccacgaacucagaaaucugccugccucugccucccgagu


 


gcugggauuaaaggcgugugccaccaccaaccagcuaaucgugagauuucuuucuuuuuucuuuucuuuucuucuuuuuu


 


uuuuuuuuuuuguuguuguuguuuuguuuuuugagacaggguucucuguguaucccuggcuguccuugaacucacuuug


 


uagaccaggcuggccuugaacuuagaaauuugccugccucugcuccggagugcugggauuaaaggcaugugccacuaccaac


 


cagcuaauugugggauuucuuaaaucuuccacacagauccuccaaaggcacaugugacaugucaccacagaucugacgguga


 


ugucacccugaggugcugggcccugggcuucuacccugcuaacaucauccugaccuggcaguugaauggggaggagcugac


 


ccaggacauggagcuuguggagaccaggccuucaggggauggaaccuuccagaagugggcaucugugguggugccucuugg


 


gaaggagcagaauuacacaugccaugugcaccaugaggggcugccugagccccucacccugagaugggguaaggagggugug


 


ggugcagagcuggggucagggaaagcuggagccuuuugcagacccugagcugcucagggcugagagcuggggucaugaccu


 


caccuucauuuccuguaccuguccuucccagagccuccuccauccacugucuccaacauggcgaacguagcuguucugguug


 


uccuuggagcuuggccaucauugcagcugugguggcuuuugugaugaagagaaggagacacacagguaggaaagggcagag


 


ucugaguuuucucucagccuccuuuagagugugcucugcucaucaauggggaacacaggcacaccccacauugcuacugucu


 


guaacugugucugcucucaguucugggaacuuccuagugucaagcucuuccuugaacucucacagcuuuccuucucacagg


 


uggacaaggaggggacuaugcucuggcuccagguuagugugggggacagaguuguccugaggucauuggagugaagcugg


 


aguuguugggugcucugggaacccauaauagcuucucuguuguaauccucugguggccugugucagaucuugcuauagau


 


auaucuuuguauauauuuuucccuaggcagggacagcucccagagcucugauauguuucucucaagauuguaaaggugaca


 


uucuauggccugauugcagaggggcacuguggacaugguuguuuucagggacucccacaauccccugugaguggugggu


 


uguugggauauugucuucauuguggugguuccugacccucauucucuaucaugaagacagcugccuggaguggacuuagu


 


gacagccagugugaccuugggucuucauuuuucuuuagagaacagcgccugauguucccugugagccuaugggcucaaugu


 


gaagaauuguggagcccagccuucgccuacacaccaggaccugucucuugcauugcccuguguucccuuccaccgccaaccu


 


uccgggucugcag


 









108
AW124268
uuuuuuuuuuuuuuuuucagaauaauugcagacaaauuccauuuauuuuucuaaaaaccu




cauuaucuaaaauuuauacagccucacauuccuaaaccaccucuggcacuuuucuugaau




uaagucaaggcguacacagcuccgaaagaaaaauagagauccgguuccaggaagauggcc




augaggacucgcagauaugucuccucggaccuggaagcgugucagccaugggauccacua




auccaccauccgguacacagggucacccacucucaggcucccaagcuucuccaccgagaa




auacaucccaaaaaguggagaugacugguauauacucuucacagaaggaucacacaggcg




auagcucuucagggucuccaguggc


 


109
AF090738
Sequence below.







cucuagaugaauacacucucaugagggccaccuucucugguaguucaggucgccucugcccauccuucccugcguccucucc


 


caaaguggccuacaacccuuacccagaggacuauggagacauugagauugguucucacaagaguuccgcaguaaccugggg


 


gcagaugauggcuacaugcccaugaccccuggggcagcccuuaggagugguggucccaauagcugcaagagcgaugacuaca


 


ugcccaugagccccacaagcgugucugcucccaagcagauccugcagccacgcuuggcagcggccuugcccccuuccggagc


 


agccgugccagcacccccuucaggggugggcaggaccuucccaguaaacggagguggcuacaaagccagcuccccagcggag


 


agcuccccagaagacaguggguacaugcgaaugugguguggcuccaagcugucuauggagaacccagacccuaagcuacucc


 


ccaacggggacuaccucaacaugucccccagcgaggcaggcacugcagggaccccaccugacuucucagcagcuuugcgugg


 


aggcagugaaggccucaaaggcaucccgggccacugcuacagcucuuugccccgcucuuauaaggcucccuguuccugcagc


 


ggagacaaugaccaguaugugcucaugagcuccccugugggccggaucuuggaagaggagagacuggagccccaggccaccc


 


caggggcuggcaccuuuggggcagcuggugguagucauacccagccucaucacucagcagugccuuccuccaugaggccgag


 


ugccaucgguggccgcccugagggcuuccugggccagcgaugucgggcagugcggccuacacgccuaucgcuagagggacu


 


gcagacccuucccagcaugcaagaguacccucuacccacagagcccaagagcccuggcgaguacaucaacauugacuuuggug


 


aggcagguacccgucugucuccgccugcccccccacuacuggcauccgcggccucaucuucuucacugcucucagcuaguag


 


uccugcuucaucccuggguucaggaaccccaggcaccagcagcgacagccggcagcgcucuccacucucugacuauaugaacc


 


uggacuucaguucucccaagucccccaagccuagcacccgcaguggggacacaguaggcuccauggauggccuucucucucc


 


agaggcuucauccccauacccaccacugcccccacguccuuccacuuccccuuccuccuuacagcagccucugccaccugccc


 


cgggagaccuauaccgccugccuccagcaucagcugccacuucccagggucccacugcuggcuccucaauguccuccgagcc


 


uggggauaauggugacuauaccgagauggccuuugguguggcugcaaccccgccacaaccuaucguggcaccuccaaagcca


 


gaaggugcccgaguggccagucccacaucgggcuugaagcggcuaagucucauggaucagguaucugggguggaggcuuuc


 


cuucaagucagccagcccccugacccccaccggggugcuaaggucauccgugcagacccacaggggggacgucgucgccacag


 


uucagagaccuuuuccucuaccaccaccgucaccccaguguccccauccuuugcccacaauuccaagcgccacaauucggccu


 


cuguggaaaaugucucacucaggaaaagcagugaaggcagcaguacccugggaggaggugaugagccgcccacauccccagg


 


acaggcacagcccuugguggcugugcccccagugccacaggcuaggccguggaaccccggucagcccggagcuuugauuggc


 


uguccuggaggcagcaguucucccaugcgcagagagaccuccguggguuuccagaacggccucaacuauaucgccaucgaug


 


ugagaggcgagcagggguccuuggcgcagucucagccgcagccaggagacaagaacuccuggagccggacccguagccuugg


 


ggggcuccucggcaccgucggaggcucuggcgccagcggaguguguggggguccaggcacuggagcuuugcccucugccag


 


caccuaugcaagcaucgacuuccugucccaucacuugaaggaagccacagucgugaaaggugaggcccuuugaccuugagga


 


ugggggagggagaguggaguauuggguggcu


 









110
AI834950
uuuuuuuuuuuuuuuuucagcugugaacuauuggauuugagacaggaacagaacaaaucg




acgggccagaggaggguggagagagcacgagugguuuaaauaggggaggaugggagcaug




gcggugggggugggggaagaguuauuuacaagaaggcucagggggccagaggcucaucuu




ggaauauuuuauaacaauauauauaagauucugguuugcuuuuccuuuucgucucguaaa




ggagagagaauugcauaguucgauucuguccaagggggcagcugcauauggucggccggg




cgggucacuggucgu


 


111
AI851365
uuuuuuuuuuuuuuuuuaagugucaccacuugugacagucagcauguuacuaucagcucc




agccgcagcguuuuuaaggcguuauagauuaggcaggcaauacaaggaacacgauuaaga




aacugacacguaccacacgagcaauuuccagaggcuccucuucugcggugcacacguaac




agugcucuuguugacauucagacaguucugagggccacucugagaggcgccuuccuguuc




ucaccugacaaggauauuguuugguuugguuugguuugguuuugccuuacuauggcuuuu




cuuucaacuacauuuugugucaugcuuguuagcuaacucaaauuuugucuuuguauauuu




acuacuguaaaauuagaauaauuuacuguucaucucauccucugucacugauggaaccua




gagacgccacaagagccacugccgugacauaccucacaagcuacaucccuguccucaaaau


 


112
AW047339
cggccgcggccaccggccugcgccaagcugcugcugcggcagccaguaccucggugaagc




ccauuuucagucgcgaccugaacgaggccaagcggagggugcgcgagcucuaccgcgcuu




gguaucgggagcgugccgaacaccgugcacuuaaugcagcuggauaucacggugaaacaa




ggacgggauaaaguccgagaaauguucaugaagaaugcccaugucacagaccccagagug




guugaucugcuggucauuaagggaaagauggagcuccaggaaaccaucaaaguauggaag




cagcggacacacguuaugcgguuuuuccaugaaacagaaacaccaaggccaaaggauuuc




uuauccaaguucuauaugg


 


113
U06834
Sequence below.







gcaccugagcgcgggugccuggcgcgcccgaugggaucguugagaggcccucgacggaaagucccaaacucggaucgcauuc


 


agccaaagugaggcggcgccauggagcuccgagcgcugcugugcugggcuucccucgccacugcuuuagaagagacccugu


 


ugaacacaaaacuggaaacggcggaucugaaaugggugacuuacccucaggcagagggccagugggaggagcuaagcggccu


 


ggaugaggaacagcacagcguccgcaccuaugaggugugcgacaugaagcgucca


 


gggggccaggcucacuggcugcgcacuggcugggucccaaggcgaggugcuguccacguguaugccacgauacgcuucacca


 


ugauggaaugccugucccugccgagggccagucgcuccugcaaggagacauucacugucuucuauuacgagacgaacguga


 


uacggccacggcccauacgcccgccuggauggagaaccccuacaucaagguggacacaguggccgcagaacaucugacucgga


 


agcgcccuggagcugaagccacagggaaaguuaauaucaagacgcugcgccug


 


gguccucucagcaaagcuggcuucuaccuggcuuuccaggaccaaggagccugcauggcucugcucucccugcaucucuuu


 


uacaagaagugcuccuggcugaucacgaacuugaccuacuuccccgagacggugccucgggagcucguggugccgguggca


 


gguagcugcguggccaacgcggucccuaccgccaaccccagccccagccucuacugccgggaagauggucaaugggcugagc


 


agcaggucacgggcugcagcugcgcgccaggguacgaggcugcggaaagcaacaaa


 


guaugcagagccuguggccagggaaccuucaagccccaaauaggagacgaguccugccgccgugcccagccaacagccacuc


 


gaauaacauugggucuccugucugccugugucgaauuggguauuaccgggcccgcucagacccccggaguucaccuugcac


 


uaccccacccucugcuccaagaagcgugguucaccauuugaaugguuccacccugcgccuggaguggagugcuccccuugag


 


uccggaaggccgagagaccucacuuaugcuguucgcugccgagagugccguccuggggguuccugcuugcccugugggggc


 


gacaugaccuucgaccccgguccucgagaccugguugagcgcuggguggcaauccgagggcugcguccugaugucaccuau


 


accuuugagguugcugcuuugaauggugugucuaccuuagccacuggaccaccuccuuuugagccugucaaugucaccacu


 


gaccgugaggugccuccugcagugucugacauccgagugacucggucgucacccagcagcuugauccugucaugggcuauc


 


cccagagcacccaguggggccgugcuggacuacgaggucaaguaucaugagaagggcgcagagggccccagcaguguucguu


 


uccugaagacaucagaaaaccgagcugagcuccgggggcugaagcggggagccagcuaucugguccagguacgcgcacgguc


 


cgaggcuggcuacggucccuucggccaggagcaucacagucagacucaacuggaugagagcgagagcuggcgggagcagcug


 


gcccugauugcaggcacugcgguugugggugugguccugguccugguggucgucaucauugcaguucucugccucaggaa


 


gcagagcaaugggagggaaguugaguacucggauaagcaugggcaguaucucaucgggcacgguaccaaggucuacauuga


 


uccuuuuacuuacgaagacccuaaugaggcagugagggaauuugccaaagagaucgaugucuccuaugucaagauugaaga


 


gguaauuggugcaggugaguucggcgaggugugccggggucggcugaaggcaccagggaaaaaggagagcuguguggccau


 


caagacucugaaggguggcuacaccgagcgccagagggcugaguuccugagcgaggccuccaucaugggccaguucgagcau


 


cccaacaucauccgccucgagggcguggcaccaacagugugccgguuaugauccucacggaauucauggagaacggagccc


 


uggacuccuuccugcggcugaacgacgggcaguucacagucauccagcuggugggcaugcugaggggcaucgccucgggca


 


ugcgguaccuggcugaaaugagcuauguccaccgagaccuggcugcucggaacaucuuggucaacaguaaccuggucugcaa


 


gguguccgacuuuggccucuccagauucuuggaggagaacuccucugaucccaccuacacaaguucccugggaggcaagauu


 


cccauccgauggaccgccccugaagccauugccuucaggaaguucaccucugccagugaugccuggcgcuaugggaucguca


 


ugugggaggucaugucuuuuggggaacggccauacugggacaugagcaaccaggaugugaucaaugccauugaacaggacu


 


accggcugccuccuccuccagacugccccaccucccuccaccagcucaugcuggacuguuggcagaaggaccggaaugcccgg


 


ccccgcuuuccccagguggucagcgcucuggacaagaugauccggaaucccgcuagccucaaaaucguggccagggagaaug


 


gcggggccucacauccacucuuggaccaacggcagccucacuacucugcuuucgguucuguggucgaguggcuucgagcca


 


ucaagaugggaagauacgaggaaaguuuugcagcggcuggauucggcuccuuugagauggucagucagaucucugccgagg


 


accuucuccgaauuggagucacucuggcaggacaccagaagaaaaucuuggccagugugcagcauaugaagugggaagcuaa


 


gccaggagccccuggugggacagggggaccagcccagcaguucugaccuccaaggacucaccaccguggcagauucuucuuu


 


ccgggaggcagaguuggguggggacucacaagaugagccccucccccucgucacagccuucccauuggauugcacuuugaac


 


agagggggucggagacacagauuuggggaaccgugccauaugggaucauacaugcccuccaggcggggaaccccaacuc


 


agagugagucuuucccucaagacugggcaaagaaacaucccuacgucucuaaccucccaucuucccagaggcucucuccccaa


 


gcgccuuccaccucaacgggcaugucccugcagaccaaagagaaagggugaccagccugccaacuugggaguggaaaaugcc


 


gucccaggaggcaggaaggggcugucaggacccggugauguaaucauuggguuuugauguccugacuugcugucaccacca


 


aaggcaaucauuuuucccuuguaaaugccccuccccucaucugccuucauauugaagguucugaaguuuuacuguuuuuua


 


uuuuguuaauuuuuuccuccuuccccccucccuccccuucuuguccagauuuuguguguuaaagggcaccugguuccacua


 


ucuccuguugggaacaaggacccaucgauauguucuagaacagugccuuggaaaugcca


 









114
AA980204
ggcagcgagacgagcucacggucgaggauacgggugaagcgggacaggagcaggagccgg




agccgggccaaagcagaaggugcaggucggcgccggcgguugggcangacccagucaagc




cggacagugaggagcggaugcagacggcacgaccauggccacgauggugcuuccucgaga




ggagaagcugagucaggacgagauagugcugggcaccaaggcggugauccaggguuuaga




gacccugagaggggagcaucgugcccugcuagcuccccuagcuucucaugaagcaggcga




ggcugagcgggcucacaggagcgcugccuccuccugcgccgcucccuggaggccaucgag




cuggggcuuggggaggcucaggugauccuggcauuaucaagccaucugggggcuguggag




ucagagaagcagaagcugcgggcucaggugcggcccugguacaagagaacagugguugcg




ugaggagcuggcagggacacagcagaagcucagcgcagugaacaggcgguggcucagcug




gagaagagagcagcacaucu


 


115
AI843232
ggcagcgagacgagcucacggucgaggauacgggugaagcgggacaggagcaggagccgg




agccgggccaaagcagaaggugcaggucggcgccggcgguugggcangacccagucaagc




cggacagugaggagcggaugcagacggcacgaccauggccacgauggugcuuccucgaga




ggagaagcugagucaggacgagauagugcugggcaccaaggcggugauccaggguuuaga




gacccugagaggggagcaucgugcccugcuagcuccccuagcuucucaugaagcaggcga




ggcugagcgggcucacaggagcgcugccuccuccugcgccgcucccuggaggccaucgag




cuggggcuuggggaggcucaggugauccuggcauuaucaagccaucugggggcuguggag




ucagagaagcagaagcugcgggcucaggugcggcccugguacaagagaacagugguugcg




ugaggagcuggcagggacacagcagaagcucagcgcagugaacaggcgguggcucagcug




gagaagagagcagcacaucu


 


116
U59807
Sequence below.







augauguguggcgcgccaucugccacaaugccagccacggccgagacgcaggaggucgccgaccaggugaggcugggcccag


 


gucaggccagucugagccaggccugcggagacccggcggccucagggaccggccugcccagacuggucagguccugcagcgg


 


guuuccggggcggccacaagugugacugggagcugggggcucuggaucugguuggaagauucagggccgggaacuggggc


 


gagucuucugccgcuugcauacaagagggccacucaccuauuagggaacuagccccgggaucgguggagggauccgguggu


 


cccagagaauucaggaaggcaguguuagaaccuagacggcaccuuuuugacuuacacccaggccuaaacaagagaaagccaga


 


cugggcuacugugcuugucuccucaaaagaaagagcuaggacuguuuagcucaguggcaggaauucaacugauaccaccacc


 


accaucaccaacaccgccccucagggaaaaaaaaaaggaucaaaaccagaaguuguagaacuugcuugugccuagucugaaac


 


gaggggguggaccuugggccugggcugcccuuccugugacuguuagcagagcagagauucaguacaagguagggggagguu


 


caggguauuagcaagagaagaaaaguuaaacaaauccucucuucagcucuccugccacgccccaagcccaggacccuguccac


 


uaagccuagcugaucuugggagguguuugcucugaacugaaguggccaagaaggaagugagucagcuccaugagacccuag


 


aaaugaggaaauguuacagacacacuggccaggcaagggaaccuuggccacgugccacaucagcacucaggaggcagagacag


 


gcgagucucucugaauuugaagccagcccaguuugcuuaguuccaugccagccauagcuacauagugagacccugucccccc


 


cccccccaaaaaaaaggagcuguguuguucuuuaucaguggggccaacaguuuaccaugucccccggaaugaggaguauuga


 


aggcuggcagugugugugugugggggcaccugugcaugaaucuaaguccuuccuucucacccaccauccaggugaaguccc


 


agcuugaaucgaaagaaaaucagaaguuugaugucuuuaaagccauauccuucaagagacagauaguggcuggcaccaaccu


 


cuucaucaagguggguacugauaguagcuugccaugaacuggggacauagucucagaguagagcagaguguccugcaacuu


 


ccugcagagaaccccuuaaggggacauguacauguucugagaggaugaauuugggguguuaggguucccggccuuaaagga


 


ggagacaaggguuaucacuggcuaaguuaguggcugguggccuguucuggcucaguuucuaaggcuggguuaagccugga


 


acuggaaccuuaccuuucacucacaugucugucugucugucuuccuccagguugauguugguggagauaaaugcgugcacu


 


ugaggguguuucaaccccucccccaugaaaacaagccuuugacccugucuuccuaucagaccaacaaagaaaggcacgaugag


 


cucuccuacuucuga


 









117
AI152659
gaaaauguuaagagccaucaaauuucuggauauuuugcuaggaaaaugaaauucuacacu




uauuuuuuguagacuuuuuuuaaaugcuguuuacaugaauuguauuuuggaaaaaauauu




auacugugcacccugugaugcaugaagugauuuuauguauggucugcuaugugggcagag




gucaccuuauuccuaugaucuggaauuguuuacuuucuacaaaguaagcuuuguggggau




uuugcuuucauuuucuuuguagcugauguuauuuuaccaggugugcagcaggaauuacac




cacuguguggaauuauaaauacaucccaugugca


 


118
AI850090
uuuuuuuuuuuuuuuuuccuggugaauauuuuuauuagaggugacaguuucccaggugac




aguuuuucccaaggaagcaaaucucugcgucuauaagggaagaccacagaaccuucacuu




uguaauuuaccuguguaauuuauccaagaacacagcacagcaauugcuuuaugugguacu




cugaccuuaaguaacaaguuguuaacagaaaacacaucaaacaaaaggauaauucucuaa




uuaucaagucagccaucagcuuuucuuaggagagagagagagagugugugugugugugug




ugugugugugugugugugucugucugucugucugucuggguaucccacuuagggccaugu




gcauguuagguaaaugcuccaccacugagcuguuucuuagccgcacuuuucucagauuuc




agguuuguuuguuuguuuguuuguuuuuuaacuaggcaugaaaauaaacuucacuucaaau


 


119
AF064635
See above sequence (AI850090).


 


120
AI843106
uuuuuuuuuuuuuuuuuguggaaauuacucuuuauugaaaaauaccaguaauacugacag




acuucaaaaucaauuuacgguuccagaauacaaaguacuuaauacauuuuuuuccaaacc




uguuuguaucucaaaguuagcauuuuuguaaaucaagauacaaauaugauaacuucacua




aaauauuuuccagcuuuauucuuuaaggagcuguauaaccuucaaagucagggucccgag




gucagcagggcauggggcagaaugcaccuggcacucccugugcagcagacugcaaccaca




uu


 


121
AF033186
auggccagcuuucccccgaggguuaacgagaaagagaucgugagaucacguacuauaggg




gaacucuuggcuccagcagcuccuuuugacaagaaaugugguggugagaacuggacgguu




gcuuuugcuccugaugguuccuacuuugcguggucacaaggauaucgcauagugaagcuu




gucccguggucccagugccguaagaacuuucuuuugcaugguuccaaaaauguuaccaau




ucaagcugucuaaaauuggcaagacaaaacaguaaugguggucagaaaaacaagccuccu




gagcacguuauagacuguggagacauagucuggagucuugcuuuugggucuucaguucca




gaaaaacagagucguugcguuaauauagaauggcaucgguuccgauuuggacaggaucag




cuacuccuugccacaggauuaaacaauggucgcaucaaaaucugggauguauauacagga




aaacuccuccuuaauuugguagaccacauugaaaugguuagagauuuaacuuuugcucca




gaugggagcuuacuccuuguaucagcuucaagagacaaaacucuaagagugugggaccug




aaagaugauggaaacauggugaaaguauugcgggcacaucagaauuggguguacaguugu




gcauucucucccgacuguucuaugcuguguucaguuggcgccaguaaagcaguuuuccuu




uggaauauggauaaauacaccaugauuaggaagcuggaaggucaucaccaugauguugua




gcuugugacuuuucuccugauggagcauugcuagcuacugcauccuaugacacucgugug




uaugucugggauccacacaauggagaccuucugauggaguuugggcaccuguuucccucg




cccacuccaauauuugcuggaggagcaaaugaccgaugggugagagcugugucuuucagu




caugauggacugcauguugccagccuugcugaugauaaaauggugagguucuggagaauc




gaugaggauuguccgguacaaguugcaccuuugagcaauggucuuugcugugccuuuucu




acugauggcaguguuuuagcugcugggacacaugauggaaguguguauuuuugggccacu




ccaaggcaagucccuagccuucaacauauaugucgcaugucaauccgaagagugaugucc




acccaagaaguccaaaaacugccuguuccuuccaaaauauuggcguuucucuccuaccgc




gguuag


 


122
Z50159
auggccagcuuucccccgaggguuaacgagaaagagaucgugagaucacguacuauaggg




gaacucuuggcuccagcagcuccuuuugacaagaaaugugguggugagaacuggacgguu




gcuuuugcuccugaugguuccuacuuugcguggucacaaggauaucgcauagugaagcuu




gucccguggucccagugccguaagaacuuucuuuugcaugguuccaaaaauguuaccaau




ucaagcugucuaaaauuggcaagacaaaacaguaaugguggucagaaaaacaagccuccu




gagcacguuauagacuguggagacauagucuggagucuugcuuuugggucuucaguucca




gaaaaacagagucguugcguuaauauagaauggcaucgguuccgauuuggacaggaucag




cuacuccuugccacaggauuaaacaauggucgcaucaaaaucugggauguauauacagga




aaacuccuccuuaauuugguagaccacauugaaaugguuagagauuuaacuuuugcucca




gaugggagcuuacuccuuguaucagcuucaagagacaaaacucuaagagugugggaccug




aaagaugauggaaacauggugaaaguauugcgggcacaucagaauuggguguacaguugu




gcauucucucccgacuguucuaugcuguguucaguuggcgccaguaaagcaguuuuccuu




uggaauauggauaaauacaccaugauuaggaagcuggaaggucaucaccaugauguugua




gcuugugacuuuucuccugauggagcauugcuagcuacugcauccuaugacacucgugug




uaugucugggauccacacaauggagaccuucugauggaguuugggcaccuguuucccucg




cccacuccaauauuugcuggaggagcaaaugaccgaugggugagagcugugucuuucagu




caugauggacugcauguugccagccuugcugaugauaaaauggugagguucuggagaauc




gaugaggauuguccgguacaaguugcaccuuugagcaauggucuuugcugugccuuuucu




acugauggcaguguuuuagcugcugggacacaugauggaaguguguauuuuugggccacu




ccaaggcaagucccuagccuucaacauauaugucgcaugucaauccgaagagugaugucc




acccaagaaguccaaaaacugccuguuccuuccaaaauauuggcguuucucuccuaccgc




gguuag


 


123
X78683
Sequence below.







gaauuccgugugcaaggcgaggucuguaagcuggagcggggcagaggcuggcgggcaccccuuccugaccgcuggugccgc


 


cgccgccgccuucgggaggaucagacauggcccagaacuugaaggacuuagcuggacgccugcccgccgggccucggggcau


 


gggcacggcgcugaagcugcugcugggggccggggcgguggccuacggcguccgcgaauccguguucaccguggaaggcgg


 


ucauagagccaucuuuuuuaaucguauugguggcgugcagcaggacacgauccuggccgaauuucacuucaggauccccug


 


guuccaguaccccaucaucuaugacauucgggccagaccucggaaaaucuccucccccacaggcuccaaagaccugcagaugg


 


ugaacaucucccugcgugugcugucccgacccaaugcccaggagcuccccagcauguaccagcgucuagggcuggacuauga


 


ggagcgagugcugccguccauuguuaaugaggugcucaagagugugguggccaaguucaaugccucgcagcugaucaccca


 


gcgggcucaggugucccuguugauccgaagagagcugacagagcgcgccaaggacuucagccucauccuggaugauguagc


 


uaucacagagcugagcuucagccgagaguacacagcugcuguagaagccaagcaaguggcccagcaggaagcccagcgggccc


 


aguuuuugguggagaaagcgaagcaggaacagcgacagaagauugugcaggcugagggggaggcggaggcugccaagaugc


 


uuggagaagcacugagcaagaauccuggcuauaucaagcuccgaaagauccgggccgcccagaacaucucuaaaacgaucgcc


 


acaucacagaaccgaaucuaucucacagcugacaaccuugugcugaaucuacaggaugaaaguuuuacucggggaagugaca


 


gccucauuaaggguaagaaaugaguguggacaucaagaaccccaccaccagagaaguuggcacacuuguccagcuuggagga


 


gccagcucggggucaagcacagcccacccugccccaggcaucaugugauggacuuuucuguaucugcccucuuggauuaagg


 


aagacugagaccagcccuuucagaggcuuuccuccuuccuguguuggcugggaagcgggguggacaaugugauuucuccgu


 


gauuuccuacagccuugagccucucccagagugggggagauaaccaccaugccaggaauuc


 









124
X68193
acccaccggcuuucggaccauggccaaccucgagcguaccuucauugccaucaagccaga




uggcgugcagcgcggccuggugggcgagaucaucaaacgguucgagcagaagggguuccg




ccugguggccaugaaguuccuucgggccucugaagaacaccugaagcagcauuacaucga




ccugaaagaccguccuuucuucccggggcuggugaaguacaugaacucggggcccguggu




ggccauggucugggaggggcucaauguggugaaaacgggccgagugaugcugggggagac




caauccagcugauucaaaaccaggcaccauccguggggauuucugcauucaaguuggcag




gaacaucauucauggcagugauucaguggagagugcugagaaagagauccaucugugguu




uaagcccgaagaacugaucgacuacaagucuugugcccaugacuggguguacgaguagac




augaagaaaccagaauccuuuucagcacuacugauggguuucuggacagagcucuucauc




ccacugacaggauggaucaucuuuucuaaaacaauaaagacuuuggaacugaaaaaaaaa




aaaaaaaaaaaa


 


125
AA062013
uuuugcuuucaacaugacagaugccgcuguguccuucgccaaggacuucuuggccggugg




aguggccgcagcaucuccaagacagcggucacaccaucgagagggucaagcugcugcugc




aggugcacaugccagcaagcaaaucacggcagauaagcaauacaagggcaucauagacug




cgugguucguauccccaaggaacagggagugcucugguccuuugggcgugggaaccgggc




caaugucaucagauacuuccccaccaaggcucucaacuuggccuucaaaguuaauuccaa




gcagaucuuucugggugguguugacaagaggacccaguucuggcgcuacuuuugcaggga




accuggcaucaggugguugccgcuggggcuacauccuugggcuuuguguacccucuugau




uuuugccgguaccgucuagcagcugaugugggcaagcuggagcuaaagggaauucaaggg




ccuugggacugccugguaagacuucaaucugaugggauaagggcuguac


 


126
AI465965
auccgggacccccacggccccuuugcagcuugccacaagguucugagccccuuggaauac




uuccgccaauguguguaugacaugugugcccauaagggugacaaagccuaucucugccgu




agccuggcugcuuauacugcagccugucaggcagcuggggcagcagugaagcccuggagg




acagacagcgucugcccucuccaguguccugcccacagccacuacuccaucugcacccgc




uccugccagggcuuccugugcugcucucucuggccucacuggcugcaccac


 


127
U50413
Sequence below.







ggcacgagccgaguuggaggaagcagcggcagcggcagcggcagcgguagcggugaggacggcugugcagccaaggaaccgg


 


gacagcgaagcgacggcaggucgcagcuggaucgcaggagccugggagcugggagcuucagaggccgcugaagcccaggcug


 


ggcagaggaaggaagcgagccgacccggaggugaagcugagaguggagcguggcaguaaaaucagacgacagauggacagug


 


ugacaggaacgucagagaggauugggccucgcugcgagagucagccuggagucaagguguugacaaguugcugagaaggac


 


acgugggaggacgguggcgcgcggagggagagcccugucuucagucaccccguugauggaggacagauggacagcagccgg


 


acggccagucaccucucuuaaaccuuuggauagugguccuuugugcucugcuggacaccuguuggggauuuuagcccauuc


 


ucugaacucacuuucucuuaaaacguaaacucggacggcagugugcgagccagcuccucuguggcagggcacuagagcugca


 


gacaugagugcagagggcuaccaguacagagcacuguacgacuacaagaaggagcgagaggaagacauugaccuacaccugg


 


gggacauacugacugugaauaaaggcuccuuaguggcacuuggauucagugauggccaggaagcccggccugaagauauug


 


gcugguuaaauggcuacaaugaaaccacuggggagaggggagacuuuccaggaacuuacguugaauacauuggaaggaaaag


 


aauuucacccccuacucccaagccucggcccccucgaccgcuuccuguugcuccggguucuucaaaaacugaagcugacacg


 


gagcagcaagcguugccccuuccugaccuggccgagcaguuugccccuccugauguugccccgccucuccuuauaaagcucc


 


uggaagccauugagaagaaaggacuggaauguucgacucuauacagaacacaaagcuccagcaacccugcagaauuacgacag


 


cuucuugauugugaugccgcgucaguggacuuggagaugaucgacguacacgucuuagcagaugcuuucaaacgcuaucuc


 


gccgacuuaccaaauccugucauuccuguagcuguuuacaaugagaugaugucuuuagcccaagaacuacagagcccugaag


 


acugcauccagcuguugaagaagcucauuagauugccuaauauaccucaucaguguuggcuuacgcuucaguauuugcuca


 


agcauuuuuucaagcucucucaagccuccagcaaaaaccuuuugaaugcaagaguccucucugagauuuucagccccgugcu


 


uuucagauuuccagccgccagcucugauaauacugaacaccucauaaaagcgauagagauuuuaaucucaacggaauggaau


 


gagagacagccagcaccagcacugccccccaaaccacccaagcccacuacuguagccaacaacagcaugaacaacaauaugucc


 


uugcaggaugcugaaugguacuggggagacaucucaagggaagaagugaaugaaaaacuccgagacacugcugaugggaccu


 


uuuugguacgagacgcaucuacuaaaaugcacggcgauuacacucuuacaccuaggaaaggaggaaauaacaaauuaaucaa


 


aaucuuucaccgugauggaaaauauggcuucucugauccauuaaccuucaacucugugguugaguuaauaaaccacuaccgg


 


aaugagucuuuagcucaguacaaccccaagcuggaugugaaguugcucuacccaguguccaaauaccagcaggaucaaguug


 


ucaaagaagauaauauugaagcuguagggaaaaaauuacaugaauauaauacucaauuucaagaaaaaagucgggaauauga


 


uagauuauaugaggaguacacccguacuucccaggaaauccaaaugaaaagaacggcuaucgaagcauuuaaugaaaccauaa


 


aaauauuugaagaacaaugccaaacccaggagcgguacagcaaagaauacauagagaaguuuaaacgcgaaggcaacgagaaa


 


gaaauucaaaggauuaugcauaaccaugauaagcugaagucgcguaucagugagaucauugacaguaggaggagguuggaa


 


gaagacuugaagaagcaggcagcugaguaccgagagaucgacaaacgcaugaacaguauuaagccggaccucauccaguuga


 


gaaagacaagagaccaauacuugauguggcugacgcagaaaggugugcggcagaagaagcugaacgaguggcuggggaauga


 


aaauaccgaagaucaauacucccugguagaagaugaugaggauuugccccaccaugacgagaagacguggaaugucgggagc


 


agcaaccgaaacaaagcggagaaccuauugcgagggaagcgagacggcacuuuccuuguccgggagagcaguaagcagggcu


 


gcuaugccugcuccguagugguagacggcgaagucaagcauugcgucauuaacaagacugccaccggcuauggcuuugccga


 


gcccuacaaccuguacagcucccugaaggagcuggugcuacauuaucaacacaccucccucgugcagcacaaugacucccuca


 


augucacacuagcauacccaguauaugcacaacagaggcgaugaagcgcugcccucggauccaguuccucaccuucaagccac


 


ccaaggccucugagaagcaaagggcuccucuccagcccgaccugugaacugagcugcagaaaugaagccggcugucugcaca


 


ugggacuagagcuuucuuggacaaaaagaagucggggaagacacgcagccucggacuguuggaugaccagacguuucuaacc


 


uuauccucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuaauuua


 


aagccacaacacacaaccaacacacagagagaaagaaaugcaaaaaucucuccgugcagggacaaagaggccuuuaaccauggu


 


gcuuguuaacgcuuucugaagcuuuaccagcuacaaguugggacuuuggagaccagaagguagacagggccgaagagccug


 


cgccuggggccgcuugguccagccugguguagccugggugucgcuggguguggugaacccagacacaucacacuguggauu


 


auuuccuuuuuaaaagagcgaaugauauguaucagagagccgcgucugcucacgcaggacacuuugagagaacauugaugca


 


gucuguucggaggaaaaaugaaacaccagaaaacguuuuuguuuaaacuuaucaagucagcaaccaacaacccaccaacagaa


 


aaaaaaaaaaaa


 









128
AW120502
uuuuuuuuuuuuguuuuaauuuggcuccaaugaucgcauucucaaacuccuuugggaggg




cauuagaugacccaguauccgacgacuuagauucacacguguuuuucuccucugagcucu




uuucuccaggcucacngucuuuguuuuucaagcuuucuugggccuuugaacaauuuucuu




ccuuugaagauucuccugg


 


129
X62940
Sequence below.







agccgaguaggaccgagcugcugcagacgcgccgggucacucgagccagcaccaccguucucacgcccugagcugcagacagc


 


uaggcgguuuuaucuaguuugaaccaggcugcuggagcuugcucccucccgcccucucucuuuuuuuuccacggggcuguu


 


uuuuuaauuuggcugcaauugcaugaaaucccaaugguguagaccaguggcgauggaucuaggaguuuaccaacugagaca


 


uuuuuccauuucuuucuugucgucuuugcugggaaccgaaaacgcuuccgugagacuugacaauagcucuggugcaagugu


 


gguagcuaucgacaacaaaauagagcaagcuauggaucuggugaaaagccauuugauguaugcggugagggaggaagugga


 


aguucugaaggagcagaucaaagaacuaauagagaaaaacucccagcuggagcaggagaacaaucugcugaagacgcuggcca


 


guccggagcagcucgcccaguuucaggcccagcugcagacuggcuccccuccggccaccacgcagccacaggggaccacacag


 


cccccugcacagccagcaucccagggcucaggaucaaccgcauagccuccuaggccccaacagaacuggcugcugcugcugcu


 


gucugaacugaacagaccgaagagaugugcuagagagaagccgccuccacagucacccauuucauugcugucuacgaaagag


 


acgugagacucacacgcuguucucgcuuucuccccaguauuaagcacucauaagcuuuuggcuugaagaaauguacuaguu


 


gagugaauuaaagguuaaucagagagugagcagggaugugcccugugcaacguggcagaugucugaggaaugguuuaauug


 


accccgaggagcucugugccuuuucaacccuccccagccgcccacccugcuucugagagcucgggcggcucgccuucguggg


 


gcucgccugcgugggguucgaaagugggcugcuccuggauucugcgcucucuucuccuucccuucaaagaacucggagagg


 


ccagaaacaagacugcaauggggggcggggggagggaugaugcaguccuuauacaaaaccgacaacugucaccaaagcuuau


 


aaaacacgauaguacugucccucuuuucugaaccaucagaagacacaaaacuguuagugacacaacggugacagguagcugg


 


gaccuaggcuaucuuauuaugaagguuguuuugcuuguuguauauuuguguauguaguguaacgaauuuguaccauagag


 


gacuguccguaacuacuguuuagcuucuacacauugaaauguagauguuucauuggcugucugaaaagguguggcuugucc


 


uuccuagagagaucuacuuaaaaacugcuuuguggcaaaaaccacaccugaagaaauuuuaagaauuuggcccaguuaguca


 


cucuguguaaucccggaaucuagcugcugaagucuugcgaaguaaacuccccgugaccgaugucaguuaagcuggugauac


 


cuggagaaguggucaguugcuaaggaaguggauuucccaguagggguuucugcaccucaccuguauagucguucugcgcau


 


gucccccacacaguccccaccuguauuuaccuguucuacuugucaccuuucaauaaagcauaucaaauguugau


 









130
U60020
Sequence below.







auggcugcgcacgucuggcuggcggccgcccugcuccuucugguggacuggcugcugcugcggcccaugcucccgggaauc


 


uucucccuguugguucccgaggugccgcugcuccgggucuggguggugggccugagucgcugggccauccuaggacuagg


 


gguccgcgggguccucggggucaccgcaggagcccauggcuggcuggcugcuuugcagccgcugguggccgcacugaguuu


 


ggcccugccuggacuugccuuguuccgagagcuggccgccuggggaacacuccgggagggugacagcgcuggauuacugua


 


cuggaacagucguccagaugccuucgcuaucaguuauguggcagcauugcccgcagccgcccuguggcacaaguuggggag


 


ccucugggcgcccagcggcaacagggacgcuggagacaugcugugucggaugcugggcuuccugggcccuaagaagagacg


 


ucucuaccugguucugguucucuugauucucucuuggcuuggggaaauggccauucccuucuucacgggccgcaucacuga


 


cuggauucuucaggauaagacaguuccuagcuucacccgcaacauauggcucauguccauuuucucaccauagccagcacagcg


 


cuggaguuugcaagugauggaaucuacaacaucaccaugggacacaugcacggccgugugcacagagagguguuucgggcc


 


guccuucgccaggagacaggguuuuuccugaagaacccagcagguuccaucacaucucgggugacugaggacacagccaacg


 


ugugcgaguccauuagugacacgcugagccugcugcugugguaccuggggcgagcccugugucucuugguguucauguuu


 


ugggggucaccguaccucacucuggucacccugaucaaucugccccugcuuuuucuuuugccuaagaagcugggaaaagug


 


caccagucacuggcagugaaggugcaggagucucuagcaaaguccacgcagguggcccuugaggccuuaucggcgaugccua


 


ccgugcggagcuuugccaacgaggagggugaggcccagaaguucaggcagaaguuggaagaaaugaagacgcuaaacaagaa


 


ggaggccuuggcuuacgucgcugaagucuggaccacgagugucucgggaaugcugcugaaggugggaauucuguaccuggg


 


cgggcagcuggugaucagagggacugucagcagcggcaaccuugucucauucguucucuaccagcuucaguucacccaggcu


 


guucagguccugcucucccucuaccccuccaugcagaaggcugugggcuccucagagaaaauauucgaauacuuggaccgga


 


cuccuugcucuccacucaguggcucguuggcacccucaaacaugaaaggccuuguggaguuccaagaugucucuuuugccu


 


acccaaaccagcccaaaguccaggugcuucaggggcugacguucacccugcauccuggaacggugacagcguuggugggacc


 


caauggaucagggaagagcaccguggcugcccugcugcagaaccuguaccagcccaccgggggccagcugcugcuggauggc


 


cagcgccugguccaguaugaucaccauuaccugcacacucagguggccgcagugggacaagagccgcugcuauuuggaagaa


 


guuuucgagaaaauauugcguauggccugaaccggacuccaaccauggaggaaaucacagcuguggccguggagucuggag


 


cccacgauuucaucucuggguucccucagggcuaugacacagagguaggugagacugggaaccagcugucaggaggucagc


 


gacaggcaguggccuuggcccgagccuugauccggaagccacuccugcuuaucuuggaugaugccaccagugcccuggaugc


 


uggcaaccagcuacggguccagcggcuccuguaugagagccccaagcgggcuucucggacgguucuucuuaucacccagcag


 


cucagccuggcagagcaggcccaccacauccucuuucucagagaaggcucugucggcgagcagggcacccaccugcagcuca


 


ugaagagaggagggugcuaccgggccaugguagaggcucuugcggcuccugcagacuga


 









131
L32752
gaauuccggggccgcucucuccggcaggaucgccgcgauggccgcccagggagagccgca




gguccaguucaaggucguccuggugggcgacggcggcaccggaaagacgacauugaugaa




gcgccacuugaccggagaguuugagaaggaguauguagccacccugggcguggaggugca




cacauuagucuuccauaccaacagaggaccuaucaaguucaaugugugggacacagccgg




ucaggagaaguucggggggcugcgcgauggcuacuacauccaagcccagugugccauuau




aauguuugacguaacaucaagaguuacuuacaagaaugugccuagcuggcauaaagaucu




agugcgugugugugaaaacauccccauuguauuguguggcaacaaaguggauguuaaaga




caugaaagugaaggcaaaaccuauucucuuccaccgaaagaagaaucuucaguacuauga




cauuucugccagaaguaacuacaacuuugaaaagccuuucuucuggcuugccagaaagcu




cauuggagauccuaacuuggaguucguugccaugccugcucuugccccaccugagguagu




cauggacccagcuuuggcagcacaguacgagcaugauuuagagguugcucagacgacugc




ucucccagaugaggaagaugaccugugagaaagugaagcuggagcccugcgucagaaguc




uauuuuaggcaacuguccugugaugccagccagcggugcagugugugugccaccuuauuu




agcuaaaggagaucgugcaauucauugggaugcugaaggagaugaaugggcuucggagug




aauguggcaguuaaaauacaccuucauuuuuuuggacuugcguauuuagcccccuggaac




agaguuguucuggauuucaaagauaagacugcuaccguagcaucacaauagucaguggug




accggaauuc


 


132
AI840013
uuuuuuuuuuuuuuuuugauuuaugaaaaguuuuauuuaucaguacugugaagaauucuc




aucauaauugcuacguuaaucaaggaaaaggcacagagaagcaugugucguuugaguccu




cgauacuggaccucccagcccaugcucccuaugaggagucuagcugcugugguggucuuc




acagcuuugguuuucuggagacgaagcucaugauugcguucaugcacuccucugacagcc




accuugcuugcagaguagugcacucuucagcguugacugggcguagagcuuuucuuucucau




uuuuucugauuaacucuuuggaaauucucauuggguuuggcgggagcuucgcauau


 


133
AB020424
ucgggaaucgauugagagaccgcgaaccuguaaacggaugauaccgagucgggcaggcgu




uaugccagcccaacucgggaccucgcaucauguccgcggcuaccuuagaguguuucggga




augauuugcgguggaugaacgaaaccccgguacguccugugccaaggagcauaugucagg




acggacgcucguuaaugccucagugguggggcaacguucgcucucuaucuauacgacucu




cgacaauggauaucucggcucucgcaucgaugaagaacguagcgaaaugcgauacuuggu




gugaauugcagaauccugugaaccaucgagucuuugaacgcaaguugcgcccgaggccuu




ucgguugagggcacgccugccugggcgucacgccuuguuuugcucugugcccgugcucuu




ucgggggcggucauggaugcggagauuggcccuccgugccucgugugcggcgggcuuaag




cgcggggugucggcgucgggaagggcacgacgagugguggacggagcaccagcaggaugu




uguggucccccgucaccuuaaggggcucaagagacccggacuaggcgagccgcgcuucgu




aagaggagggcgagcugucucgcaau


 


134
AI848453
uuuuuuuuuuuuuuuuugaaguugcugccccuuuauuggugacccgggcaaguuuaagga




gaacaacauuaaagcacacaaaguguauccaugucaccagcucaaccaggaggagugagg




gucacggcaggguucucccaugguguaagaaaucaacgcaauuucaucacaccccguuac




uuuccaaguuaacgaaccgauaagaaaagauucucccuuaaacugacaaguacaauguac




auguacaugauuuuggaauaauuuaauacuuuaaccucaagauacaacuauauucuaaga




ccauuauuuuaaaggaacggauccuuacaaaaccaaaauaacccauauagcacgagguug




guuuagccuuucuucuucuuucaacaaacgugcaccacauguuucaguagcaaggccgau




gccauggauaugagagcugugauuugcagggaccaaccacaucuagaaccggggaggcca




aucanacgguggguu


 


135
AU040563
cccuuggaggauaguuuuauugacaagucgaguuagguuuuagaguaaacuuuuaucacc




ccagucaggccccuucccaggggaggcucgcugguagcucagauggccuugguggugggc




agauuguuguaguugucuuccuggcccuccagcaggcuucgggagguggcuaucuccugc




uccagccuggacuugauguccaguagcugcuuauacuccggguucuggcgcucuaugugc




ggcacgcaggugcngcg


 


136
X89749
Sequence below.







ggacugacuccuugggcagauugccucuccuccuucucaugccagaggcugcugaugaggaaagguccaggggacugucca


 


ugcugucuucauccucagagucacugccugaugcugcaacaagacccuucuuguuuagcaauagugguuggaacacucucu


 


uguaaguuaccggagcacuaguauaggaggaggaucaucgacuacccucccgccacuccacggcugcuggcuccuagaaacc


 


ccagcuucaccucucacugggacucgaguuccagaaugaaaagcaagaagggucuuguugcagcaucaggcagugacucuga


 


ggaugaagacagcauggacaguccccuggaccuuuccucaucagcagccucuggcaugagaaggaggagaggcaaucugccc


 


aaggagucaguccagauucugcgagacuggcuguaugaacacagauacaacgccuaucccucagagcaagagaaagcacugc


 


ugucccagcagacacaccuguccacacuacaggucuguaacugguucaucaacgcccgccgcaggcuccuuccugacaugcu


 


gagaaaaggauggcaaagauccaaaucaguucacgauuucccgccguggggccaagauuucagaagcuagcucuauugaagcu


 


gcaauggguaucaaaaacuucaugccaacucuagaagagagcccauuucauuccugcguaguuggacccaacccaacccuag


 


ggagaccagugucucccaaaccucccuccccaggauccauuuuggcucgcccgucagugaucugccauaccacugugacugc


 


auugaaggaugggccuuucucucucugucagccgauuggugugggacagaguacagauguaccgcaaauagcacccagcaac


 


uuuacagacaccucucucguguacccagaggacacuugcaaaucuggacccaguccaaacccucagaguggucuuuucaaca


 


cuccucccccuacuccaccagaccucaaccaggauuuuaguggauuccagcuucuaguggauguugcacucaaacgagcggc


 


agagauggagcuucaggccaaacucacagcuuaaccguuuuuucaaacaaaacaguucuccaaaauacgguccugauugccg


 


ggggugauggcaagagaugcauuauuuuauauauuuuuuc


 









137
AW125390
uuuuuuuuuuuuuuuuuggugguuaucaagugcacuuuauugaauccacuguggauagau




aaaugaguguuacaccugcguguagggaggggcaaggagggacgcagcugcggaggguga




agcacuucaggaccggaagucggaauccucuauuaagugugaagguuuugagcguuaaga




acaaugaugaugacacuaacaauggugauaacaaccaucaggaugcugaggaccaaggug




cugauguucaggcacuuagcaguggaggcguaggccugggcuccagucacaucacccacc




aucuuccgaucccuagacuucacggaguaggcauaggcuaugaagcccaggcagcagaag




uucaugaagaguguauugaacagggaccagaccacauggucaggcaccgacaccucucug




ggcauguugaucacaguaguucugacagaagccga


 


138
X05862
Sequence below.







aagcuucaggauacagugcacacucguaaauaaaaacuacaggcugcugcgaauuauauuucaacugaccggagaggcaaag


 


ccugacuguccauuaacccuuaacuuccaaacgcaaacugcuuacugcaucuuuuggcauuuuaccuuaugccuuguuagg


 


uccaaggcaagagaagcgucaucaauaaccacgcaugugcaacagcuuuuccagaggaaagguguggguggcucuuaaaaga


 


gccuuugaguuaggagugugaguuaaacgagcucacuuggagcugguguacuuggugacugccuuggugcccuccgacacc


 


gcgugcuuggccagcuccccgggcagcagcaggcgcacggccgucuggaucucccgggacgugauggucgagcgcuuguug


 


uaaugcgccaggcgggaagccucgcucgcgaugcgcucgaagaugucguucacgaacgaguucaugaugcccauggccuug


 


gaggagaugccggugucggggugcacuugcuucagcaccuuguacacguacaccgaguagcucuccuugcggcugcgcuug


 


cgcuucuugccguccuucuucugggccuuggugacggccuucuuggagcccuucuucggggcgggagcggacuuggcggg


 


cucaggcauacugagaggaugaagugaacuaaguugaaaaaggauaacuaaaaguuaaugacuguucuggcugcaauuuuaa


 


acaaacuuacggcuauggcaaccugaaucaccauacgucauguacuaacaguccaaucaaaacaagggauuuucaaaccaggg


 


cgccauugguaaccaauguguaaccaaugaaaucucuccguuuucgcguccagccuugacuauauauacuaugcguauacgu


 


uuuugcuucuuacugcggugguuaucuacagcugaguuaugucuggacguggcaagcaaggacguggcaagcaaggaggca


 


aggcccgcgccaaggccaagacgcgcuccucccgggccggccugcaguuccccgugggccgcgugcaccggcugcuccgcaa


 


gggcaacuacucggagcgcgugggcgccggcgccccgguguaccuggcggccgugcuggaguaccugacggccgagauccu


 


ggagcuggcgggcaacgcggcccgcgacaacaagaagacgcgcaucaucccgcgccaccugcagcuggccauccgcaacgacg


 


aggagcucaacaagcugcugggccgcgugaccaucgcgcagggcggcguccugcccaacauccaggccgugcugcugcccaa


 


gaagaccgagagccaccacaaggccaaggggaagugaaaccaaacauuacgaaucaccaaggcucuuuucagagccacucacu


 


uucucaaagagaccuaacacuacugggauagugcauugugggaaauacguguauuaaccuuccuccuauuuucccugcuug


 


ugguuaguucaaccccuaagccuuaggcuaagaguauauugguuuuuggaaggcaggcacccaaccucggaccuaguacaua


 


aaacagacacaucuugaacuccaggccagccuacucugcaggacgaguuccaggacagaccggacugcacaaagaauugucuu


 


gaaauguuccuuuaucagcacauaugcugauaaacaacuaaucacuguacaaucaauccucacuugaauccuguuuaugugg


 


caugauugacaaguccugccauuuggcaaagucaaaaucagcaaaggauguuaaagcauuuggugguaucacagcuaaaac


 









139
AW046181
uuuuuuuuuuuuuuuaugcaaauaguuuucaagauuuuauugcaaaccaaaauugguuua




ucgcacacaaaaaaaguugugugguaaggaggaggaauuguacaggauuauaacccaugu




uaauuacaguacauuaaaaugaugguuuacaaauaagccuguaaguuuaaauaucuagug




uuauaacccaauguacagacuuccuuuacacgauacauacaauaaucaggaaugcaaaag




aauaugaacaaagggaaaaaaaacauaaauaaugcccguuuuauaggugacauuuuaaac




aauugaaaacaccaaccggcuuugacugacaacuggggcauugguccauaaaaacccuuu




cuaaaaauagaaauau


 


140
U10118
Sequence below.







gaggcugcucaagagcugcgguugggucaccgcuucauguuucucugccgauucuggggaaagauggcaacgaaugaugcu


 


guucugaagaggcuggagcagaagggugcagaggcggaucagaucaucgaauaucucaagcagcagguugcucuucuuaag


 


gagaaagcaauuuugcaggcaacaaugagagaagaaaagaaacuucgaguugaaaaugcuaaacugaaaaaagaaauagaaga


 


gcuaaagcaagagcugauucuggcagaaauucauaacggaguggagcaagugcguguucgauugaguacuccacugcagacg


 


aacuguacugcuucugaaaguguggugcagucuccaucaguagcaaccaccgccucuccugcuacaaaagagcagaucaaag


 


cgggagaagaaaagaaggugaaagagaagacugaaaagaaaggagagaaaaaggagaagcagcagucggcagcagcaaguacu


 


gacuccaagccuaucgacgcaucgcgucuggaucuucgaauugguuguauuguuacugccaagaagcacccugaugcagau


 


ucacuguauguggaggaaguagaugugggagaagcagccccgcgcacggucgucagcgggcuggugaaucauguuccucua


 


gaacagaugcaaaaucguauggugguuuuacucuguaaucugaagccugcaaagaugcggggaguucugucucaagccaug


 


gugaugugugccaguucaccagagaaaguggagauucuggccccucccaacggguccguuccuggggacagaauuacuuuu


 


gaugcuuuuccuggagagccugacaaggagcuaaacccuaagaagaagaucugggagcagauccagccugaccugcacacca


 


augcugaguguguggccacauacaaaggagcucccuuugaggugaaggggaagggaguuugcagagcccaaaccauggccaa


 


uaguggaauuaaauaagugcucuguaacugaaagacauuggcgaaaacuuaauaacaauaaagagaaguguguuuaucacuu


 


acauau


 









141
AW212775
ggccuuguuuuugguuugcaauaaagaguauuucuuuaaaaggcacauuuuguuaaauag




gcaguuccccuccugccucuuccuuuguagcaguguacugcauccuagaaacauuuagca




aagcagcccuuagccuccccgacccccuuucccucccucccagca


 


142
AI846302
uuuuuuuuuuuuuuuuuaaacaaugacgccguuuauuuaaaauguuuacucccagaaaua




uagauauaaaaaaaaaaauaagacaauuaacagcacuaaaccaggcaccuucaaccgaau




cccaccauccucguuaacucccuuccuguuacccuuuguagaugaccagaagauuucagg




agccccuggacagccagagugguuccugcccagggcuucccgccuuccuccuguccuaga




gcuucccgugggaaagcuugggugagaauuuuagccuaaagggagggggcuguggccggg




cacuuugcgcucauccacugcagg


 


143
M22998
Sequence below.







acaggguacaguugugcgucagggcguggaggucuggcgggagacgcauaguuacagcgcguccguucuccgucucgcagc


 


cggcacagcuagagcuucgagcgcagcgcggccauggaucccagcagcaagaaggugacgggccgccucauguuggcugugg


 


gaggagcagugcucggaucacugcaguucggcuauaacacuggugucaucaacgccccccagaagguuauugaggaguucua


 


caaucaaacauggaaccaccgcuacggagagcccaucccauccaccacacucaccacgcuuuggucucucuccguggccaucu


 


ucucugucgggggcaugauugguuccuucucugucggccucuuuguuaaucgcuuuggcaggcggaacuccaugcugaug


 


augaaccuguuggccuuuguggcugcugugcuuaugggcuucuccaaacugggcaaguccuuugagaugcugauccuggg


 


ccgcuucaucaucgguguguacugcggccugacuacuggcuuugugcccauguaugugggagaggugucaccuacagcucu


 


acguggagcccuaggcacacugcaccagcugggaaucgucguuggcauccuuauugcccagguguuuggcuuagacuccau


 


caugggcaaugcagacuuguggccucugcugcucagugucaucuucaucccagcccugcuacaguguauccuguugcccuu


 


cugccccgagagcccccgcuuccugcucaucaaucguaacgaggagaaccgggccaagagugugcugaagaagcuucgaggg


 


acagccgaugugacccgagaccugcaggagaugaaagaagagggucggcagaugaugcgggagaagaaggucaccaucuugg


 


agcuguuccgcucacccgccuaccgccagcccauccucaucgcuguggugcugcagcugucccagcagcugucggguaucaa


 


ugcuguguucuacuacucaacgagcaucuucgagaaggcaggugugcagcagccuguguacgccaccaucggcuccgguauc


 


gucaacacggccuucacuguggugucgcuguuuguuguagagcgagcuggacgacggacccugcaccucauuggccuggcu


 


ggcauggcaggcugugcugugcucaugaccaucgcccuggccuugcuggaacggcugccuuggauguccuaucugagcauc


 


guggccaucuuuggcuuuguggccuucuuugaaguaggcccugguccuauuccaugguucauuguggccgagcuguucag


 


ccaggggccccguccugcugcuauugcuguggcuggcuucuccaacuggaccucaaacuucauugugggcaugugcuucca


 


guauguggagcaacugugcggccccuacgucuucaucaucuucacggugcuccucgugcucuucuucaucuucaccuacuu


 


caaagucccugagaccaaaggccgaaccuucgaugagaucgcuuccggcuuccggcaggggggugccagccaaagugacaag


 


acacccgaggagcucuuccacccucugggggcggacucccaagugugaggagccccacacccagcccggccugcucccugcag


 


cccaaggaucucucuggagcacaggcagcuagaugagaccucuuccgaaccgacagaucucgggcaagccgggccugggcgc


 


cuuuccucagccagcagugaaguccaggaggauauucaggacuuugauggcuccagaauuuuuaaugaaagcaagacugcu


 


gcucagaucuauucagauaagcagcagguuuuauaauuuuuuuauuacugauuuuguuauuuuuuuuuuuuaucagccac


 


ucuccuaucuccacacuguagucuucaccuugauuggcccagugccugaggguggggaccacgcccuguccagacacuugcc


 


uucuuugccaagcuaaucuguagggcuggaccuauggccaaggacacacuaauaccgaacucugagcuaggaggcuuuacgc


 


uggaggcgguagcugccacccacuuccgcaggccuggaccucggcaccauagggguccggacuccauuuuaggauucgccca


 


uuccugucucuuccuacccaaccacucaauuaucuuuccuugccugagaccaguuggaagcacuggagugcagggaggaga


 


gggaagggccaggcugggcugccagguucuagucuccugugcacugagggccacacaaacaccaugagaaggaccucggagg


 


cugagaacuuaacugcugaagacacggacacuccugcccugcuguguauagauggaagauauuuauauauuuuuugguugu


 


caauauuaaauacagacacuaaguuauaguauaucuggacaaacccacuuguaaauacaccaacaaacuccuguaacuuuacc


 


uaagcagauauaaau


 


ggcugguuuuuag


 









144
X64837
Sequence below.







gcuuucuaaacuagcaagcaucguguggguccuucaggagugggagugcagacagaccugacagcguccgcuaagcgacacu


 


gacuguacuuccacuccugaaggacccacacgaugcuuucuaaacuagcaagucugcagaccauugcugcucugcgccgagg


 


aguccacaccucagucgccucugccacgucuguugccacaaagaagacagagcaaggcccaccauccuccgaguacauuuuug


 


aacgggaaucuaaauauggugcacacaauuaccauccuuugccuguagcccuggagagaggaaaaggcauuuauauguggga


 


uguggaaggcaggcaguacuucgauuuccugagugcuuauggugcugucagccaaggacacugccacccaaagaucauagau


 


gccaugaagagucagguggacaagcugacauuaacaucucgggcuuucuauaacaauguccuuggugaauacgaggaguaca


 


ucaccaagcuuuucaacuacaacaaaguucucccuaugaauacaggaguggaggcuggagagacugcauguaagcucgcucg


 


ucguuggggcuacaccgugaaaggcauccagaaauacaaagcaaagauuguuuuugcugaugggaacuuuuggggucgaac


 


acuaucugcaaucuccaguuccacagauccgaccaguuaugauggcuuuggacccuucaugccaggcuuugaaaccauccca


 


uauaacgaucugcccgcacuggagcgugcucuucaggauccaaauguugcugccuucaugguggagcccauccagggugaa


 


gcaggcguuaucguuccggauccaggauaccugacaggaguucgggaacucugcaccaggcaccagguccuguuuauugcu


 


gaugaaauacagacaggauuggccagaacugguagauggcuggcuguggaucaugagaaugucagaccugauaugguucuu


 


cuugggaaggcccuuucuggcgguuuauacccugugucugcagugcugugugacgaugagauaaugcugaccauuaaacca


 


ggcgagcacggcuccacauacggcggaaacccacuaggcugccgaauugccauugcggcucuugagguuuuagaagaggaga


 


aucuugcugagaaugcagacaagaugggcgcuauccugaggaaggagcucaugaagcugcccucugacguugugaccucag


 


ugagagggaaaggguugcuaaaugccauugucaucagagaaaccaaagacugugaugcuuggaaggugugccugcgacuuc


 


gagauaacgggcuucuggccaagccaacccacggugauaucaucaggcuugccccuccccuugugaucaaggaggaugagau


 


ccgggaguccguggagaucaucaacaagacuaucuuguccuucugagaguaggaacucuggggagccaucuucagacagggc


 


ucuugugaaacucugcuugcaguggccagagccugucuccugaaaggcauauauuucaguugaugcauaauagagugacac


 


cuaggaaccugcagguggcugcgugacagaaaagugagagcgagaggcgaggcgucucuuuguugagguuugacugugugg


 


gaacuuucuaaggagaaacggacccaucugcguacagccugcagauggaggccugcagucauuuacgugcgucuuuacaguu


 


uccuugcugaugugaaugguuuguauuuagaaguuauuucugagauacuacagaacaguuaaaucauuauaaucaaugaau


 


guuaaguugauugaagguuaagcauauguaaaauacuaguuuaaaguaaacuuuucauuggccaacaccagaauguauuau


 


auagauucugagaauucauuacuaaauuacacuuugcuugauugcaauuuguaaaacauuuauuuucaguauuucuuugaa


 


uaaagcuuaauguuucuuuuuacgccaacagaguauuuuguauuuccauuuugguaauaaucaguguauuauuucauccu


 


gaugacuggcauuucaucaccuauugagaucacuggguguguuucaggccuuuuauucuaaauaaagcuaugaccaguuuc


 


ugucugu


 









145
AI843119
uuuuuuuuuuuucuuuuccgacgcccacaagaggaauaagagauuuaaugauggaaagua




uggggaaaucacaguuuucagacaugaguaaucaaaaacuugacauuuuucuugauaucc




aaaucuagaugucuguaucaaaccagaggugauggccuuggggauggcagugaagacugu




uaggaccauuagaucagau


 


146
AI837786
uuuuuuuuuuuuuuuuuacaguuuuaaaacaauacacagcuuucucgggcugaagcaauu




gcaagaacguauugguauugguauauuacagcuacauacaagguuuaugaauagcaaugg




agaaaaauaaguuauuuaaauauugacuucauaaagagaaagugcaauguuguuaguugu




cauaucacuugcuugacaguuugugggguuucuucccuaucaauuuuaacaaucaagaua




acauggacucaagacagaauuuuucgggaaccucacucaguccucacacagcagugacuu




gggaaucuacguguguuccaccgcaguugugaaacacacuacuccguguccaggacucau




uucucagagaagaaucaauucgaguuccauccacaccuggggucgggacaca


 


147
U41465
Sequence below.







ccgggcucgaauucucuagacucgaguuuagagaauucgagcucucccaguuuuaaagcaaaauuuuggacugugaagcaa


 


ggcacugggcaaacacaacauggccuccccggcugacagcuguauccaguuuacccggcacgcuagugauguucuucucaac


 


cuuaaucgccuccggagucgggacaucuugacggacguugucaucguggugagccgugagcaguuuagagcccauaagaca


 


gugcucauggccugcagcggccuguucuacaguaucuucacugaccaguugaaaugcaaccuuaguguaaucaaucuagauc


 


cugaaaucagcccugagggguuuugcauccuccuggacuucauguacacaucuaggcucaaccugagggaaggcaauaucau


 


ggcggugaugaccacagccauguaccugcagauggagcauguugucgacacaugcaggaaguucaucaaggccagugaagca


 


gaaauggccccugcacuuaaaccuccccgugaagaguuccugaacagccggaugcugaugccccaugacaucauggccuacc


 


gaggucgugaggucguggagaacaauaugccacugagaaauacucccgggugugagagcagagcuuuugcuccuccucugu


 


acaguggccugucaacaccaccagccucuuaucccauguacagccaucucccgcucagcaccuuccucuucucugaugagga


 


gcuccgagaugccccccgaaugccuguggccaacccuuuucccaaggagcgugcccuccccugcgacagugccaggcaaguc


 


ccuaaugaguauagcaggccagccauggaggugucccccaguuugugucacagcaacaucuacucgcccaaggaggcagucc


 


cagaggaggcucggagugacauacacuacagugugccugagggccccaagccugcugucccuucugcucggaaugcuccaua


 


cuuccccugugacaaagccagcaaagaagaagagagaccuucuucggaggaugagauugcccugcauuucgagccccccaau


 


gcacccuugaaccggaagggucugguuaguccccagaguccccagaaauccgacugccagcccaacucacccacagaguccug


 


cagcagcaagaacgccugcauccuucaggccucuggcucuccgccagccaagagccccacugacccgaaagccugcaacugga


 


agaaguauaaguucaucguucucaacagccucaaucagaaugccaaacccgagggcucugagcaggcagagcugggucgccu


 


cuccccucgagccuacccugcaccgcccgcuugccagccgccuauggagcccgcgaaccuugaucuccaguccccgaccaagc


 


ucagugccaguggggaggacucuaccaucccccaagccagccggcucaauaaucucgugaacaggucccugggaggcucccc


 


ccgaagcagcagugagagucacucaccacucuacaugcaccccccaaagugcacauccugcggcucucaguccccacagcaua


 


cagagaugugccuccauacugcugggcccacguucccggaggagaugggggaaacccagucagaguauucggauucuagcu


 


gugagaaugggaccuucuucugcaacgaaugugacugccguuucucugaggaggccucgcucaagaggcacacgcugcagac


 


gcacagugacaaaccauacaaaugugaucgcugccaggccuccuuccgcuacaagggcaaccucgccagccacaagacugucc


 


acacgggugagaaacccuaucgcuguaacauuuguggagcgcaguucaaucggccagccaaccugaagacccacacucgaau


 


ucacucuggagaaaagcccuacaaaugugaaaccuguggggccagguuuguucagguggcccaccuccgugcccacgugcuc


 


auccacacuggagagaagccguaccccugugaaaucuguggcacucgcuuccggcaccuucagacucugaagagccaucugc


 


gcauccacacaggagagaaaccuuaccauugugagaaguguaaccugcacuuucgucacaaaagccaacugcgacuucauuu


 


gcgccagaagcacggcgccaucaccaacaccaaggugcaauaccgcgugucggccgcugaccugccuccggagcuccccaaag


 


ccugcugaaugaagcauggaguguuccucgcccuuuccucuccagccccuucucagaaucuacccaaaggaugcuguaacac


 


uuuauacaaaggucaucccaugauguagugccucucucauccacuagugcaaaucauaguugggguggggguggg


 









148
U70494
ucgcgguccgacggaggagugggcgcugggaucucgcugagcguccgccuggccucgucu




cuuccucgcucgucggagcuucagcacgguccgagauggcuggcgguaaggcuggaaagg




acuccggaaaggccaagacaaaggcgguuucccgcucgcagcgagccggcuugcaguucc




cugugggccguauucaucgacaccugaaaucuaggacaaccagccacggacgugugggcg




cgaccgccgcuguguacagcgcagccauccuggaguaccucaccgcagagguacuugagu




uggcaggaaaugcgucaaaagacuuaaagguaaagcguaucaccccucgucacuugcagc




uugcuauacguggagaugaagaauuggauucucugaucaaagcuaccauugcugguggug




gugucaucccacacauccacaaaucgcugaucgggaagaaaggacaacagaagacuguuu




aaggaugccuggauuccuuauuaucucaggacucuaaauauuccuaacagcuguccagug




uuggugauuccaguggacuguaucucugugaaaaacacaauuuugccuuuuuguaauucu




auuugagcaaguuggaggcuuaauuagccuuccaaccaaccaaauuucugcauucgaguc




uuaaccauauuuaaguguuacuguggcuucaaagaagcuauugauucugaaguagugggu




uuugauugaguugacuguuuuuaaaaaacuguuuggauuuuaauugugaugcagaaguua




uaguaacaagcauuugguuuuguacagacauuguuuccacucugguggauaagcucaaua




aaggucauaucccaaacuagcuuuaaacuugcuuaauaaucgggucuuaccuuagaucuc




acucagcaacaaguacauucucugcuuacuaauuaaacagugcaucuguagucauaaaaa




aaaaaaaaaaaaaaaaaaaaaaaaaaaaa


 


149
D17666
Sequence below.







caccaccgugcacgcagcuccgggcccgugggguguugguucuugcccucguaacccccucuguccagccaccaugauaagc


 


gccagcagagccgcggccgcgcgucucgugggcaccgcugcgucccggagccccgcagccgcccguccccaggugagaagcu


 


gccaugccuuccggugggggcuccaggcccggacucgagugaggcaggccuugccuucgggucagacucuaggaaaaauccg


 


gagcgaagggauguaacggaccuucugugggcauuguuggccuucuugcagggcuuuagcuucgaacugugcugagucaca


 


auccuuggcguuccuaagucuuuaccccgcuaauugagacgucuguccccccucuaaccugugcgcuuugaaugugccugg


 


acuuaggcaguggacguaguuuacuggaaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


 


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnuuuuacauacuaaggacuaaagcuug


 


cauguguuccucagaauaugaaaagcccaaguucuuguguaguugauggcugaugcaacuuuuuuccccccaggauggcug


 


gaauggccuuagccaugaggcuuuuagauuuguuucaagaagagauuaugcguaaguacaaccucaguuucucugagaaaa


 


aaaaaaaacacuuauugaaccucaaagcuuggauggguugggugcguuauacauuuguacuuguaguuuauucaauaugcc


 


acugguaacaccaacauaaaacacaguucuucguauuggagaccacuguucagaugaccauggaauuucauuucuuacagau


 


cagaagcaaucaagggugcagugguugguauugauuuggguacuacuaacuccuguguggcuguuauggagggcaaacaag


 


caaaggugagcaugauuggaaaccugaggucacuuagauacccagucuggcauuaaguacauaggaaugcugagucggagcc


 


cagguuaguggugggcacuuuaauccuaguaaaggcagagggaucucugaguucaggaccagccuagaguacaaagugagn


 


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


 


nnnnnnnnnnnnnnnnnnnnnnnacuuuaaucagugucuuugggaauuuuagguccuggagaaugcugaaggugccaga


 


acuaccccuucugugguugccuuuacagcagauggagaacgacuuguugguaugccagcaaaacggcaagcugucaccaauc


 


caaacaauaccuucuaugcuacuaagcgucuuauuggacgacgauaugaugacccugaaguacagaaagacacgugaguaau


 


aggaaaaucaguccagaagacuggugcuuugaucaaaguucuguggauaccuugaguucuguggaucaccuuggaucacuu


 


uuucauuauuucugcuugggaagaaaucacaccaccaucagaggcauauagguuuuuuuuuuguuauuucuuuguuguug


 


uuguuuuccuauuuauuuguuuguuuguuuggggggggguuucuuuguguauuuuccuggaacucauucuguagaccag


 


gcuggnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


 


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnucaugugauauaugaugaacuuagagugguuaaguuucacagggauaguu


 


uacuuacauaaucuuucugucuuuaaguaagaauguuccuuuuaaaauuguccgugccuccaauggugaugcuuggguuga


 


ggcucauggaaaacucuauucuccaagucagauuggagcauuuguguugaugaagaugaaagagacugcagguaaguggau


 


uuauuucacauuuaggaaaauuggaaugugcuguuuauuucucugcauuaauacugauuaacuucauauucuguagauaau


 


ggagucugaagcuunnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


 


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngaauucaugcuccuccugcugccuccugggugcuaaguugca


 


aggugauagcucagguacucacucuagugucuuucuuggggugcucuuuuccaaggccucucuacauauuaagccacaaag


 


gagucuguugccccucaagaggaugagauguggaauauuaggcuacaguuuuguugccuuuuuuuuauuuuccuaacaug


 


guaccacaauugaauuuuauucuuuguuucccagaaaauuacuugggccacacagcaaaaaaugcugugaucacagucccug


 


cuuauuucaaugauucacagcgacagguaaaauuagaucucuuguuugcugggaguggaggugggguaccugaguuaaagg


 


auggaaagauagauuuauuucuacuuucucuaggccacuaaggaugcuggccagauaucugggcuaaaugugcuucgagug


 


aucaaugagccuacagcugcugcucuagcuuacggucuggacaaaucugaagauaaaguguaaguuggucagaugacguagc


 


auuaccugcauuuacagggguuguguguguguguguguguguguaauuuuacuacaauuuguguggguccguguguugu


 


gguacauuuguacauuuguacauggcauggauauggaugucaaagauunnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


 


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaaaccagu


 


aguugguguguuacuaauuuuacuuguuucuguaugacaugcuuauaugauacguuaacaggcaugccacuuagguugau


 


aacuacauucaguuauuaaguauuucaggaaauaucauaguuaauaauuaaacuuuuggucuuuuaauucguuccuuuguu


 


uuguuccuuggaacuuaacuuacuuauuuauuuuuuagcauugcuguguaugauuuaggugguggaaccuuugacauuuc


 


uauccuggaaauucagaaaggaguguuugaggugaaaucuaccaauggggacacuuucuuaggaggggaagacuuugacca


 


agcuuuguugcggcacauugucaaggaguucaagagagagguuaguuaccacugcuuagucaccacugguuaagguguagg


 


cguuggguuguugagaauuuuuguuuguuugcauugcuuuuagcuuuguuaauagcuuuuuuauacuaagguaacuaac


 


uauacuucagauucauggguaaacuaaaccaguuuaguuauauaaucuuagauugggaacaaaagaccaagugacaguguua


 


uaguagggagaagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


 


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnacuacucucucgcagucuauauaugucuccuaauccuauuuau


 


agacagggguugauuugaccaaagacaacauggcgcuucagaggguucgggaagcugcugagaaggcuaaaugugaacuuu


 


ccucaucugugcaggugagggauggaaaaaucccaguacugagcauauuugaauaguguauucuaauuuaccuaaugucag


 


uguagcucuuuacaguuuucuguuggcugaaaacuuggggcaugagcaaaggaacaacuugaugaucaguucuuuucauuu


 


gaaugaaugaaguagauuuauggauguguguaucuuuugccugcaugugugucuguacuacauuugugcuugguuucugu


 


ggcggccagaagaggguaucagaacugacaugucaguguuggggannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


 


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncacacugaguc


 


uaaauucugaucaugucuuucagucguguuauguuacuuugagugaguaucaaagaucacgucucccaucugacguguggu


 


ccugugcagacugacaucaacuugccauaccuuaccauggaugcuucuggaccaaagcauuugaauaugaagcugacucgag


 


cucaguuugaaggcauugucacagaucuaaucaagagaacuauugcuccgugucagaaagcuaugcaggaugcagaagucag


 


caagagugacauaggagaagugauucugguugguggcaugacaaggaugcccaagguauggacucaugguauuucuccuag


 


aggaaaaaaauaacaaugcauucuugaggcaaauggcuuguguuguguguggaaacaaaugugauccauucuucuaguguu


 


cuuuaaagaguggugagaccagacucaccaaaaagugcuuuuagucgccugugauggcucauguaggaggauggccuugag


 


uucuggguaagaugcagcuacagaauucuaccuugcacacacacuuaaacccagucugguaaagagaaguuguuaagcuunn


 


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


 


nnnnnnnnnnnnnnnnnnnnnncagauguaaaauugauaauacuucuuccuaagauugggcgauuguguagaauaugaga


 


acuguauuuuauaaccccuugucaugugccuucuauuucaaaugauauccucugggaagcuagauaauuaaauucuucucu


 


cauuuaaguggacaguggaugagaugcucugaaguugucaaauacaaacaagucugcagucuuggauaugaaucucucuga


 


cuugcugucuggcaggcguauucuguuuggcuccaucagucgcccuggguguuggcuaacagguucuuucucccugaugc


 


uuagguucagcagacuguacaagaucuuuuuggcagagccccgaguaaagcuguuaauccugaugaggcuguagccaucgg


 


agcugccauccagggagguguguuggcuggugacguuacagacgugcugcuccuggaugucacuccccucucucuggguau


 


ugagacucugggaggcgucuuuaccaaacuuauuaauaggaacaccacuauuccaaccaaaaagagccagguaagagccauu


 


cuuuuuuccugccuauuaacagucccaaguuguacaagugcuguuuacaaucacuuuaugaacucuuuaaaacuuuguuuc


 


uaagacuauacuaacuggacugggugnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


 


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnccuagguguuuucuacugcugcugauggac


 


aaacucaaguagagauuaaagugugucagggggaacgagagauggcuggagacaacaaacuucuaggacaguucacuuuggu


 


aaguguuuuugagucugaguaucaugcuuuuggggucuauagcuugcaaagcuccaaacugcugacauuacaggcauauug


 


uguuauuuuuuaaaaagaacguuauguacaugaguuaugaaacccaugauuuuaguuuuuuaccuaaagugcuuuguguu


 


uucagaauuugaaauuuucaaagccugggaaauguucagacucagaagcaaugcuaacucagaaguuaguuuuauccugau


 


uacucauuuuaaaaaacuuaauagcuacugguucuggucagcauugcuacaguagagaaguuuauuugcuguaaauucugg


 


gcacauauaaccaucaugguuauuaacuucuugaagcccagugauuucagaaagcacuaaaacuaccaccaucacuuaaaauc


 


ucaagguuuugaacauucagugaagauacuuguuuuaggaaacaagugguuaguuggccugauuuggaaaugagaauacau


 


gggccuuucaaaggagcucacucuggauauuuauuuuagauuggaauucccccagccccucguggagugccccagauugaa


 


guuacauuugacauugaugccaaugggauugugcacguuucugccaaagauaaaggcacuggucgugagcaacaga


 









150
X14897
Sequence below.







auaaauucuuauuuugacacucaccaaaauagucaccuggaaaacccgcuuuuugugacaaaguacagaaggcuuggucaca


 


uuuaaaucacugagaacuagagagaaauacuaucgcaaacuguaauagacauuacauccauaaaaguuuccccaguccuuau


 


uguaauauugcacagugcaauugcuacauggcaaacuaguguagcauagaagucaaagcaaaaacaaaccaaagaaaggagcc


 


acaagaguaaaacuguucaacaguuaauaguucaaacuaagccauugaaucuaucauugggaucguuaaaaugaaucuuccu


 


acaccuugcaguguaugauuuaacuuuuacagaacacaagccaaguuuaaaaucagcaguagagauauuaaaaugaaaaggu


 


uugcuaauagaguaacauuaaauacccugaaggaaaaaaaaccuaaauaucaaaauaacugauuaaaauucacuugcaaauua


 


gcacacgaauaugcaacuuggaaaucaugcaguguuuuauuuaagaaaacauaaaacaaaacuauuaaaauaguuuuagagg


 


ggguaaaauccagguccucugccaggaugcuaaaauuagacuucaggggaauuuugaagucuucaauuuugaaaccuauua


 


aaaagcccaugauuacaguuaauuaagagcagugcacgcaacagugacacgccuuuagagagcauuacuguguaugaacaug


 


uuggcugcuaccagccacagucaauuuaacaaggcugcucagucaugaacuuaauacagagagagcacgccuaggcagcaag


 


cacagcuugcugggccacuuuccucccugucgugacacaaucaauccguguacuugguguaucugaagcgcacgcugcaccg


 


cggcacugcccggcggguuucugggcggggagcgauccccgcgucgccccccgugaaaccgacagagccuggacuuucagga


 


gguacagcggcggucugaaggggaucugggaucuugcagagggaacuugcaucgaaacuugggcaguucuccgaaccggag


 


acuaagcuuccccgagcagcgcacuuuggagacguguccggucuacuccggacucgcaucucauuccacucggccauagccu


 


uggcuucccggcgaccucagcguggucacaggggccccccugugcccagggaaauguuucaagcuuuucccggagacuacga


 


cuccggcucccgguguagcucaucacccuccgccgagucucaguaccugucuucgguggacuccuucggcaguccacccacc


 


gccgccgccucccaggagugcgccggucucggggaaaugcccggcuccuucgugccaacggucaccgcaaucacaaccagcca


 


ggaucuucaguggcucgugcaacccacccucaucucuuccauggcccagucccaggggcagccacuggccucccagccucca


 


gcuguugacccuuaugacaugccaggaaccagcuacucaaccccaggccugagugccuacagcacuggcggggcaagcggaa


 


guggugggccuucaaccagcacaaccaccaguggaccugugucugcccguccagccagagccaggccuagaagaccccgagaa


 


gagacacuuaccccagaagaagaagaaaagcgaaggguucgcagagagcggaacaagcuggcugcagcuaagugcaggaaccg


 


ucggagggagcugacagaucgacuucaggcggaaacugaucagcuugaagaggaaaaggcagagcuggagucggagaucgcc


 


gagcugcaaaaagagaaggaacgccuggaguuuguccugguggcccacaaaccgggcugcaagauccccuacgaagaggggc


 


cggggccaggcccgcuggccgaggugagagauuugccagggucaacauccgcuaaggaagacggcuucggcuggcugcugc


 


cgcccccuccaccacccccccugcccuuccagagcagccgagacgcaccccccaaccugacggcuucucucuuuacacacagug


 


aaguucaaguccucggcgaccccuuccccguuguuagcccuucguacacuuccucguuuguccucaccugcccggaggucuc


 


cgcguucgccggcgcccaacgcaccagcggcagcgagcagccguccgacccgcugaacucgcccucccuucuugcucuguaaa


 


cucuuuagacaacaaaacaaacaaacccgcaaggaacaaggaggaggaagaugaggaggagaggggaggaagcaguccgggg


 


guguguguguggacccuuugacucuucugucugaccaccugccgccucugccaucggacaugacggaaggaccuccuuugu


 


guuuugugcuccgucucugguuuucugugccccggcgagaccggagagcuggugacuuuggggacaggggguggggcggg


 


gauggacaccccuccugcauaucuuuguccuguuacuucaacccaacuucuggggauagauggcuggcuggguggguaggg


 


uggggugcaacgcccaccuuuggcgucuugcgugaggcuggaggggaaagggugcugaguguggggugcaggguggguug


 


aggucgagcuggcaugcaccuccagagagacccaacgaggaaaugacagcaccguccuguccuucuuuucccccacccaccca


 


uccacccucaagggugcagggugaccaagauagcucuguuuugcucccucgggccuuagcugauuaacuuaacauuuccaag


 


agguuacaaccuccuccuggacgaauugagcccccgacugagggaagucgaugcccccuuugggagucugcuaaccccacuu


 


cccgcugauuccaaaaugugaaccccuaucugacugcucagucuuucccuccugggaaaacuggcucagguuggauuuuuu


 


uccucgucugcuacagagcccccucccaacucaggcccgcucccaccccugugcaguauuaugcuaugucccucucacccuca


 


cccccaccccaggcgcccuuggccguccucguugggccuuacugguuuugggcagcagggggcgcugcgacgcccaucuug


 


cuggagcgcuuuauacugugaaugaguggucggauugcugggugcgccggaugggauugacccccagcccuccaaaacuuu


 


cccugggccuccccuucuuccacuugcuuccucccuccccuugacagggaguuagacucgaaaggaugaccacgacgcaucc


 


cgguggccuucuugcucaggccccagacuuuuucucuuuaaguccuucgccuuccccagccuaggacgccaacuucucccca


 


cccugggagccccgcauccucucacagaggucgaggcaauuuucagagaaguuuucagggcugaggcuuuggcuccccuauc


 


cucgauauuugaauccccaaauauuuuuggacuagcauacuuaagagggggcugaguucccacuaucccacuccauccaauu


 


ccuucagucccaaagacgaguucugucccuucccuccagcuuucaccucgugaaucccacgagucagauuucuauuuuuu


 


aauauuggggagaugggcccuaccgcccgucccccgugcugcauggaacauuccauacccuguccugggcccuagguuccaa


 


accuaaucccaaaccccacccccagcuauuuaucccuuuccugguucccaaaaagcacuuauaucuauuauguauaaauaaau


 


auauuauauaugagugugcgugugugugcgugugcgugcgugcgugcgugcgugcgagcuuccuuguuuucaagugugc


 


uguggaguucaaaaucgcuucuggggauuugagucagacuuucuggcugucccuuuuugucaccuuuuuguuguugucuc


 


ggcuccucuggcuguuggagacagucccggccucucccuuuauccuuucucaagucugucucgcucagaccacuuccaacau


 


gucuccacucucaaugacucugaucuccggunugucuguuaauucuggauuugucggggacaugcaauuuuacuucuguaa


 


guaagugugacugggugguagauuuuuuacaaucuauaucguugagaauuc


 









151
AJ006289
Sequence below.







caccugauucccggaggcccgagcccuuagucugggcgggguggcgcgggccggaaggacgccaucccggccugggccaugg


 


aggcucccgcaccgucccucacggaggaggauuugacugaagugaagaaggacgcuuuagagaauuuacguguuuaccugu


 


gugagaaaaucauagcugagagacauuuugaucaucuacgugcaaaaaaaauacuaaguagagaagacacugaagaaauuuc


 


uugccgaacuucaaguagaaaacgggcugggaaguuguuagacuacuuacaggagaaccccaggggccuggacacccuggug


 


gaauccauccgcagggagaaaacacagagcuuccugauucagaagauaacggaugaggugcuaaagcuucggaauauaaaac


 


uggagcaccucaaaggccugaagugcagcagcugugagcccuuugcagccggagccaccaacaaccucucuaggugcaauuc


 


cgaugagagcaaucucucugagaaacagagagcauccacugucauguaccacccggagggagaguccagcacggcucccuuc


 


uucucuauggcgucgucccugaacuugccaguccuggaaguuggcaggacugaaaacagcagcuucucuucagccacucuuc


 


cucgaccuggggacccuggggcucccccuuugcccccagaccuucgguuggaagaggggggaaguuguggaaacucaagug


 


agauguuucuccccuuacggucacgggcucuuucacgccaaugauacaucaccgccuaguuguuuuacuagugaugcaaaau


 


gcugugaaggaggccaucuuucuauacaaaccacggugacaggucacucacauucgaugcgugccuuuaaaaucaguguaca


 


cauucucuguaaauaggauuuguuaggguaaagaagcgcucuggggcggcgugguguaaucaugguggucgugacuuuuc


 


cauaauguccuuucuuuuuuauuauuuuuagguguuugcguauuuugaacuuuucauaagauuaauuuuaucggaauauu


 


ucucaauuugagaaaacaacuuguggauugggaauaauguuuuuagcacauuuaugcuacaaauuuucagucugauuguuu


 


uucccacugaucuggcaguauauuuuagcaguaagcuguugugugucaggaaagcuggacacgggaaagcugccgacacac


 


ucagcagugucccacuccuuaguucugagaagccgucggguucugaggagacaccugguggcacugagccuggugaccuca


 


gugggccaaaauuuguuuuauacucacccugccagcgugagugucuuacuuucacaggccuuguguccucagucuuaucuu


 


aaaggauguuaucuuggcagggcaucacuuguaauuaauggaugauacuuguaauugacuaaaguccucgcucugagccgu


 


uuguucuggcuccgagagcgcugacaugugaagcauggugagcagcgagggaacugacaggauguggccguggccagugug


 


gcuuuaguguuugcaucaggcagccaccagcuccauccguguucuuacugcuuuacaaaguuugacuaacuuuacacauuu


 


uaaaaaugcugauugucuucguuuaaauuauaauuuuaccuauuucuugacaucuaacuccuauuuauuucuauuauuuaa


 


aaauuaagaaaugaaaauuugcuauuaacaauaaaguuuuuuuaaugu


 









152
X12944
Sequence below.







ggggggggggggucagcgccgacguccccugccgccaccaugcccaaaagaaaggcugaaggggaugcuaaaggagacaaaa


 


ccaaggugaaggacgagccacagagaagaucugcaagguugucugcuaaaccugcuccuccaaagccagagcccaaaccuaaa


 


aaggccccugcgaagaagggagagaagguacccaaggggaagaaggggaaagcugacgccgggaaggaugcgaauaauccug


 


cagaaaauggagaugccaaaacagaccaggcacagaaagcugaaggugcuggagaugccaagugaugugugugcauuuuuga


 


uaacuguguacuucuggugacuguacaguuugaaauacuauuuuuuaucaaguuuuauaaaaaugcagaauuucguuuuac


 


uuuuuuuuuuuuuuuaagcuauauuguuagcacacagaacacuucauuacugggugggggaaggaucaugugucaguaac


 


aaaaucucucccaagcuggauugaggacagaaaaccucuuucccugauaauuuuggaaggcuccuguuggcucccaggagag


 


agauccuggucuugaccuagguggccaccaaggcacaacaaugccuuguggucugggaaaacuauaaauucacuuuuauauc


 


cucuucccccuguacuaucaacauagacuuaauucccuuaaaaaccagagaccuguuggaaccuggcccccaaaauugguuu


 


cccaguccauugagugauggggacuuugcagugacuucauugaguguucucaaaagagcacugguuccuuuuauaaaagau


 


uguggaucuucagauugauaauucugccuaaaagucagggucggcuugugaaaaguuguuaaaacaacauccuuaauguga


 


aaugucaacccucacucuaagcuacuucccccuuuucaaagcauugaaugaagacuucauuggguuuuauaguggcuuucu


 


gauuuugguagucauaucagaagggaauuuggaaguucuuguauauuguugcauugucugcccauguccugccugaauacc


 


augauuguuuaugaaagaaucuuaauaaagcugguuacaguuaggcuggaaaa


 









153
AW061302
uuuuuuuuuuuuuuuuuggaaguccauaaguaguuuauugucuucaagacuacagugugg




auuccucucccagagaagggucuuucagaggcaggggacugucacccaggugcaggccgu




cuacuugucauuuucauacauggcuggauucuuccuuuucgacugcucaaacuccugguu




gccccauguguagaucagguagaccacuacaaacggcggcgccacgcgcaggaugcgcuc




gcgagugcggcgcaacacguuggggaugccuuugcugaaauagcuugggaaggcgcgcug




cucaaagggcgacaagcugua


 


154
U67328
Sequence below.







caugaagccagagauguggaagaugugucuagacugcaucaaugaacugauggauacguuggaugcacauuccaacaucucu


 


gucggagagaacauuuuggcagagagugagaacuuacacaacuuugaucaguucacuccguguacgacgcugcauccuaacu


 


uugguggagcgaauggaugaagaauuuaccaaaauaaugcaaaauacugauccucacucccaagaguauguggagcaccuga


 


aggaugaggcacaagugugugcaucauugagcgagugcagcgcuaccuggaggagaaagguaccacugaggagaucugccag


 


aucuacuuaaggcgcauccugcacacguacuacaaguuugacuacaaggcccaucagcggcacguuacuccuccugaaggau


 


ccucaaagucugagcaagaccaggcagaaaaugagggugaggacucagcugugcuaauggaaagacugugcaaguacaucua


 


ugccaaggaccguacagaccggauccguaccugugccauccucugccauaucuaccaucaugcgcuccacucccgcugguau


 


caggcccgugaccucaugcucaugagccaccuacaggacaacauucagcacgcagacccgccggugcagauccuguauaaccg


 


uacuauggugcaacugggcaucugugcuuuccgccaaggccugacaaaggaugcacacaauggcacuucuggauauucaguc


 


aagugguggugccaaggagcuucuaggucaggguugcugcugcgcgcuugcaggagcgaaaucaggaacaggaaaaggua


 


gagcgacgccggcaggugcccuuucaccugcacaucaaccuggagcugcuggagugugucuaucuggugucagcuaugcuc


 


cuggagauccccuacauggcugcccaugagagcgaugcccgccgacgcaunaucagcaagcaguuccaccaccaacugcggg


 


ugggcgagcggcacgcccugcuagguccucccgagucaaugagggagcauguggucgcugccuccaaggccaugaagaugg


 


gcgacuggaagaccugccacaguuucaucauuaaugaaaagaugaaugggaaagugugggaccuuuucccugaggcugacaa


 


aguucgcaccaugcuaguucggaagauccaggaagagucucugaggaccuaccuuuuuaccuacagcagugucuaugacuca


 


aucaguauggagacacuaucagauauguuugagcuggaucuacccacuguucacuccaucaucagcaagaugaucauuaacg


 


aagaauugauggcuucccuggaccagccgacacagacuguggugaugcaccguacugagcccucugcccagcaagaaacuug


 


gcucugcaagcuggcugagaaaacuuggcacccuaguggagaauaauggacggguguuugaccaaaaacagggaaccuaugg


 


uggcuauuuccgagaccccaaggguggcuaccggaaaaauggaggcuaaaugccccgugguggcuacccccagcaacagucu


 


cagacaaccuccugaguuccccacuucagucacccuguggacagaccaucuaaccuuuuucuccuaacucaccccaaucauua


 


aagaucuuuugaggaauuaaaaaaaaagaaagaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa


 









155
AI604314
uuauuaauuaaaaaacaauuuauugaaaaagaguagugcuuuguacaaauucccauugca




gcccccagauaucaacugaucucuuuccagcuuugguaguaggguauaaaaauaucaaaa




cuagguaaguucugauguaagauuucuaugggauuauuuuagaauauauagauuugugua




guuuggcaaguaucauuucuaugcauuuacauuacauauuaagcacagauucuguggcaa




aacaucuuugcaugauuacuuuacacacacaaauauaguaaaacuuacauaguacaaauu




cacauaagacuccauucugucuauaacuucauccaugugguuuuaccaugaauuauaauu




cuuaaccucuccuauaacugucagcuuccauuuaauuuugaaaguaucacuucacaaaga




gcacuucauuugcuuuuagaguauacauagacu


 


156
AI845121
cggccgccaagaaguauaacaugcgaguggaagacuacgagccauaccccgaugauggca




ugggguauggcgacuacccgaugcuccccaaccgaucacagcaugagagggauccguggu




aucagugggaccacucagaacucaggaugaacuggggugaaccgauacacugggaccuag




acauguacaucaggaaucguguggacacgucaccuaccccuguguccugngaugucaugu




guaaacaucucuucggcuuuguggcuuucaugguuuucauguucuggguagggcacgugu




ucccuuccuaccagccuguggguccgaagcaguacccuuacaaaaaucuguaccuggagcg


 


157
AW047756
uuuuuuuuuuuuuuuuugaugcaaaugucuuuauuuuccacuuaaacaaguuucccuuuu




gcacuggccuguggcacaaaacagauggcuggguggugacauuaacugucaaguuaguga




gaugcagagauggugagacacugcauuugagugcauaauacuuuuauuccagaggaacgc




caugcagcccaguuacaccuuuaggucagaaaggcugaugcgugaccagccucuauugcc




ucccuugguaagaaggacccacaagugcagaguccaacagaugcuggcucugagcugaac




ucagggcauuccaauuaccacuuucuucuucaccuacacagggccugcucagauguccuu




uuuacaacuccauaagcccuuuggccaaagucccugcaguguuuggggaggaccuuccca




cccuucaccagucagugucugaucugguggag


 


158
AI838021
uuuuuuuuuuuuuuuuuaauaucuguaauaguuuauuucaaagauuugacauuuacaagu




agaggcaccacaugcuaucugacaguaaaauacugcagggacugaaggccaaggagagag




auccacagaagacaggccuguagugcaggcauugcaucgaccuugcccacagugcuuugu




ucccaacucaggacaguacuuuagugcuugcuucauuuacuggaaaaguucacuggacau




aguuuccacuucuucccccacagcuuccagcucagcaaacuuaagcuacuacuccucgau




gcucucauagaggcucuugauuugugucuggaagaacuuggcaagcucuacucguuuggc




uuucagugucggugucagaaguccguuuucaa


 


159
AW122893
uuuuuuuuuuuuuuuuucugagguauuaaaauaucuagacugaauuuugccaaauguaag




agggagaaaguuccugaagacucugacuacuugcuuauuuuugauugaccuucuaugcuu




augucauuacugccucacaacguguuugauguccuuuaaugauacaaagugagccugugc




cuucauuuucuugcccauuuugguaccccucgugccg


 


160
M59821
Sequence below.







gcgcccgaacgucuagcagaguaccugcugcuguaagcuugucgucugggcugcaccgcccgucuuaacccauucucgacuu


 


aacuacucucgucgaacaagcauggaaguacagaaagaagcgcagcgcaucaugacucugucgguauggaagauguaccacu


 


cucgcaugcagcgagguggcuugcgacuccaccggagucugcagcuaucccucguuaugcgcagcgcucgagagcucuaccu


 


cucagccaagguagaagcccaccagcccgaguucccgccaucccgcagggcucuugacccucgccugcacccgccgcgggaag


 


ccgaaguugcaguggaaguagcgucccccgaagccgugcagccuccggagcccauggauacgcaagaggaagugcugcgagu


 


ccaggagaccccugcgcucugugacccgccccccgcuagagucagccgcaagcgccggagcagcagcgauuugagcgacagua


 


gugaugccggacugguaccaagcaagaaggcccgucuagaagagguggagggggaggcgacgucggagguucccgaucgcc


 


ugcagcuuccuccggcacaaagcgaaggugccuucccuaaccucgcccgcguccuccaaaggcgcuucuccagucuccugaac


 


uguggacccgccgugcccccgccgacgccccccacgugcgaggccaagccagccugccgcccggccgacaauaugcucaacgu


 


gcuggugcgagcugugguggccuucugagagcucugguggcuucuuucgagcggcgccaccggagcggagaacgcacaccc


 


gaggcgaaggccggcgggggccgugaagaagagccgcggcccgagcugccgagaggccagggcaaggacugaggagcgaggg


 


gcgcgggcgccuucucccagacgugcguccauaggugcuauuaaaggacugucccuuccuuggcuuggagaagggacaccu


 


agaucuugaaucucagggucgaacucucuaggggccaggcugcccuuucaaggccguuucacuaccauucgcguuucggcc


 


ccuacaagugggcacgcuugugcaagcggucagaguugcgucaugggacagacgcgggugcuuccuguugccuugcguggg


 


uguggggccugggaggaggccaggguguggacccgcccuagggacugggaagugacuugagucaccucgcccccacaggcu


 


gcugugggugagccugaacugaaccaaucaaaucugcgcagaguugaaguggcuggagaccccgggacuggucaaccuagau


 


gaucgccuggcguggaccaccgcgggacgggugggccgcuggucguaguugcugccguagacacagcuucuucgggcagga


 


aagaaaauuuuuuuuuuaccagcguguuuaagaaagucuguuuacuuuucccacgguggguuguuuaauuagcaacuaccu


 


ggaguuuuacaaugucagcuaggaaaauaaagaccaucggugu


 









161
M13805
See above (same Accession Number).


 


162
AI845886
uuuuuuuuuuuuuuuuugguuccacuuaaguugcauguuuuauuucucccaaucccagca




auagcacagaagcccaucauguccaucccagacugguuucuaguaggcugagaugacagg




gagccucaguaacgcuaauggcacagagggcucccaaaugccaggcacaacugugccucc




acacuggugacugcccagagugcccuggccccaguguguuggcacucagucugacuuuac




aacgcaaccugcaccuuugaaagggacagucugggaguggggagugugagggagugaagc




ucaaacugccuccugucagcucacccuuucaacauuaaacagagaccaagagagaaacag




uuccaauauuucacauauauuucuucuugugcagucuaagccgagaaugccauguaaaug




ggucacugcgaaaugcagcaauuuagu


 


163
X53157
gucucgggcgagauggcuucaagguuacuucgcggagugggcgcuuuggcggcgcaggcc




cugaggcgcacggcccguggcgcggccgugacccgcuccauggcuucuggaggugguguc




cccacugaugaggagcaggcuacugggcuggagagggagaucaugauagcagcacagaag




ggacuggacccauacaauaugcuaccuccaaaggcagcuucaggcaccaaggaagacccu




aaucuagucccguccaucagcaacaagagaauagugggcugcaucugugaagaggacaac




uguacugucaucugguuuuggcugcacaaaggcgagagucagcgaugccccaacugugga




acccauuacaagcuggugccccaccaaauggcccacugagccccuguguuaucuuuucag




aauguaaagaaaaacuucucucuaauaaagacuagccauugcaccugcuccuccc


 


164
U19118
See above (same Accession Number).


 


165
AF062071
Sequence below.







gcgcaccgccygyguygcgcgscagcgucgucuaggugcaucgcgggcccccgcagrwagaaaaauauggcucaggagacua


 


accagaccccagggcccaugcuguguaguacaggauguggcuuuuaugggaauccuaggacaaauggaauguguucuguuu


 


gcuacaaagaacaucuucagagacagcagaauaguggcagaaugagcccaauggggacagcuagugguuccaacaguccuac


 


cucagauucugcaucuguacagagagcagaugcugguuuaaacaacugugaaggugcugcuggcagcacaucugaaaaauca


 


agaaaugugccuguggcugccuugccuguaacucaacaaaugacagaaaugagcauuucaagagaggacaaaauaacuacccc


 


gaaaacagaggugucagagccaguugucacucagcccaguccaucaguuucucagcccaguucuucucaaagugaagaaaaa


 


gcuccugaguugcccaaaccaaagaagaacagauguuuuauguguagaaagaaaguuggccuuacaggguuugacugccgau


 


guggaaauuuguuuuguggacuucaccguuacucugacaagcacaacuguccauaugauuacaaagcagaagcugcagcaaa


 


aaucagaaaagaaaauccaguuguuguggcugaaaaaauccagagaauauaaaauuacuacaugugaagagacugaaacuuu


 


guuuuuauuuuaauauaucguaggaaaacauuaaagagcagaugcauggccauuuuccuuugauguucuccagaguuuugc


 


uuuauacuugucugucauauaauugaucuuuuaggauguuuggguguuuguuacaggcagaauuggauagauacagcccu


 


acaaauguauaugcccuccccucaguaaaauuggacaaaaauaugcacaacaaauugaaauacacauauacuaggaacaaaau


 


uuaguuccacgugccaaacuaaaggaaugaaaucucugcauguuugcagcauaucugccuuuugggaauguaaucaaggua


 


uaaucuuuggcuaguguuaugugccuguacuuaaaaaaaaaaaaaugguacaccagaaaaggacuggcagucuacuaccaua


 


gucaaacuucaccuuaauuucgacaugacuuuuggaagcaggaagaaagcuacaaaacugguauuugguaccaugugugagc


 


cugguuaaauuggucuucuaaaagcugucaauuaggacauucugcgaaagguaacaucacaacugguucuaagucaaaccau


 


caagucaacagcagggugccugagauaaucuuggaagcuuauugugcuggccugcaccagaagauaucugcauucucauuac


 


uaaaauuguagcacagaacugcacuaggauuuguuuacaaggagaaauuaaacucuguuugguuuucacauauagcagcuc


 


uguuaaauaacaugcaucugaauuuuaaguugcaaagguaucugaacaguuaauuuuucaugugcaucuuuuguugaaugu


 


uuugguucaagaaagaauguuuaaagcuuuuuaaagacuucaguucuuaauguaacuguacccuucugcauggaaaaucau


 


aaccaacauggcugcaguagacuucuuuagugguauccagcaccacuugcagagggcugcuuuaucauauuguacuugggu


 


guaggacucuaguguucuuggguguauugcaugggcugcauuaucuacagcauuguacaauaacaacuagaaaaggcggua


 


uacuucacugaugcuugucugguaauaucacuucuguguuaaaauggaagguuuuuugugauguaugaaacuuguguuuu


 


uuauauauaaaugaguauaguuagauuaguguugugguaaugccuguuuucaucuguaaauaguuaaguauguacacaaca


 


aggcacuacuucugauuuuugcaguguucaguccuaguuuuucuuuauuaaaacauugaguuuugcuucaauuuuaugua


 


ccuuaguucuaaguuagauuugcagauguguacagauaguucauauuuauguauugcacauaaucaugcuauucagcauug


 


augcuauauuguauuauguaaauaauaaaagcaguguacagagggaaaa


 









166
U10404
augacagaugccgcuguguccuucgccaaggacuucuuggccgguggaguggccgcagcc




aucuccaagacagcgguagcacccaucgagagggucaagcugcugcugcaggugcagcau




gccagcaagcaaaucacggcagauaagcaauacaagggcaucauagacugcgugguucgu




auccccaaggaacagggaguccuguccuucuggcgugggaaccuggccaaugucaucaga




uacuuccccacccaggcucucaacuuugccuucaaagauaaauacaagcagaucuuucug




ggugguguggacaagaggacccaguucuggcgcuacuuugcagggaaccuggcaucaggu




ggugccgcuggggcuacauccuugugcuuuguguacccucuugauuuugcccguacccgu




cuagcagcugaugugggcaaagcuggagcugaaagggaauucaaaggccuuggugacugc




cugguuaagaucuacaaaucugaugggauuaagggccuguaccaaggcuuuaauguguca




guacagggcauuaucaucuaccgagcugccuacuuugguaucuaugacacugcaaaggga




augcucccagaucccaagaauacucacaucuucaucagcuggaugauugcacagucuguc




acugcugucgcuggccugacuuccuauccuuuugacacgguucgccgucguaugaugaug




cagucuggacgcaaaggaacugauaucauguacacaggcacgcuugacugcuggcggaag




aucgcgcgcgaugaagggagcaaggcuuuuuucaagggcgcaugguccaacguucucaga




ggcauggguggcgccuuugugcuugucuuguaugaugagaucaagaaauacacauaa


 


167
U07634
Sequence below.







cguagaaguugucucugucggcgggcgggcgggcaggauuggggcaccgagaccggcgugcggacagcagggaucgcgggg


 


agcgaggggugcggcauggagcuccgggcagucgguuucugccuggcgcugcugugggguugcgcgcuggcggccgcggc


 


ggcacagggaaaggaaguuguuuuguuggacuucgcagcaaugaagggagagcucggcuggcucacgcaccccuauggcaaa


 


gggugggaccugaugcagaacaucauggacgacaugccuaucuacauguacucggugugcaacgugguauccggcgaccag


 


gacaacuggcuccgcaccaacuggguguaccgggaggaggccgagcgcaucuuuauugagcucaaguucacggugcgagacu


 


guaacagcuucccggguggcgcccaugccugcaaagagaccuucaaccucuacuaugcagagucagauguggacuauggcac


 


caacuuccagaagcgccaguucaccaagauugacaccaucgccccugacgagaucacggucagcagugacuucgaggcucgca


 


acgucaagcugaacguagaggagcgcaugguggggccccuuacccggaagggcuucuaccuggccuuccaggacaucggcgc


 


cugcgugcggcugcucuccguucgcgucuacuacaagaagugucccgagaugcugcagagcuuggccugcuuccccgagacc


 


auugcugucgcuguuuccgauacacaaccccuggccacgguggccgguaccugcguggaccaugccguggugccuuauggg


 


ggcgagggggcucucaugcacugcacgguggauggcgaguggcuggugccauccgagugccugugccaggaaggcuacgag


 


aaggucgaggaugccugccgagccuguucuccaggauucuucaagucugaggcaucugagagcccuucccuggagugucca


 


gagcauacccugccauccacagagggugccaccuccugccagugugaagaaggcuauuucagggcaccugaggacccacugu


 


ccaugucuugcacacguccacccucugccccuaacuaccucacggcaugcaugggugccaaaguagaacugcguuggacagc


 


ucccaaggacacugguggccgccaggacauugucuacagugucacuugugaacagugcugcgcagagucuggcgagugugg


 


gcccugugaggccacggugcgcuauucagaaccuccucacgcccugacccgcacgagugugacagucagugaccuggagccc


 


cacaugaacuauaccuucgcugucgaagcacgcaauggcgucucaggccuggugacuagccgaagcuuccggacugccagcg


 


ucaguauuaaccaaacagagccccccaaagugaggcuggaggaccgaagcaccaccucccugagugucaccaggagcaucccg


 


gugucacagcagagccguguguggaaguacgaagucaccuaccgcaagaagggggaugccaacagcuauaauggccgccgca


 


cggaaggcuucuccgugacccuggaugaccuugcuccggauaccacguaccuggugcaggugcaggcauggacgcaggagg


 


gccaaggagccggcagcaaagugcacgaguuccagacgcuguccacggaaggaucucgcaacauggcggugaucggcggugu


 


ggcuguagguguuguuuugcuucugguacuggcaggaguuggccucuucauccaucgaaggaggaggaaccugcgggcuc


 


gccaguccucugaggauguccguuuuuccaagucagaacaacuaaagccccugaagaccuauguggauccucacacuuacga


 


agaccccaaccaggcuguacucaaguuuaccaccgagauccacccauccuguguggcaaggcagaaggucauuggagcagga


 


gaguuuggagaggucuauaaagggacgcugaaggcauccucggggaagaaggagauaccgguggccaucaagacacugaaag


 


cgggcuacacugagaagcagcggguggacuuccugagcgaggccagcaucaugggccaguuuagccaccacaauaucauccg


 


ccuggaggcgguggucucuaaauacaaacccaugaugauuaucacagaguacauggagaauggagcgcuagacaaguuccuu


 


agggagaaggauggugaguucagcguacuucaguuggugggcaugcugagggguaucgcauccggcaugaaguaccuggcc


 


aacaugaacuacgugcacagagaccuggcugcccgcaacauccucgucaacagcaaccuggugugcaagguguccgauuuug


 


gccugucgcgugugcuggaggaugaccccgaggccaccuacaccacaaguggcggcaagaucccuauucgauggacagcccc


 


agaggccauuuccuaccgcaaguucaccucagccagcgauguguggagcuacggcauugucaugugggaagugaugacuua


 


uggcgaacggcccuuacuggaacugucaaaccacgaggucaugaaagccaucaacgacggcuuccggcuccccacgcccaugg


 


acugcccuucagccauuuaccagcucaugaugcagugcuggcagcaagagcgcucccgccggcccaaguuugccgacaucgu


 


uagcauccuggacaagcucauccgacgccccgacucccucaagacgcuggcugacuucgauccccgaguguccauccggcug


 


cccagcaccagcggcucggagggaguccccuuccguacgguguccgaguggcuggagagcaucaagaucgaacaguacacgg


 


aacacuucaugguggcuggcuacacggccaucgagaaggugguacagauguccaacgaagacaucaaaaggaucggagugcg


 


ucuuccuggccaccagaagcgcauugccuacagccugcugggacucaaggaccaggucaacacaguggggauuccuaucuga


 


guccauuggggcugucacacaauacuugaagagccacaguggucucccugccgaucuggugcuggcccacuggaacuuuau


 


uuauuucuguuuccucgucuaugccucccuaggacucugcaggggcuuuuugaaugacaccugccugagccugggaaacuu


 


ggauugcuggucagggcucucuuuccccugaaaaggacccagcuaagaacuuagcaguuugccauggccuucccagcauccc


 


cugaggcuaaaguuccaccaagagucgauaucgacgagggacauuuccaaacggaccuccccaucuucauuuggccuccuga


 


gaagccacucuggagcugaggcuaagcacuaagcccaggaccauaugacuagcacuguaccgcccgccccuaguuagagggu


 


agguuuuggacuuggcuggguuguggucacaagcaaucucccagugccuuuuacagaccccagucugcccucccgucgagg


 


gccagcuucuugcuuuccuagggcccucucaggaugcuuggcugugcugagguuuuuauuaaauauauauuuuauacuug


 


cggaaagaaugaguguguggcagggacuugccagggcuggagacagaggauccccugcaacaagacauucccgggcugggg


 


gcuggcggaccugcaggagacuuuccgccaccaccccgucuccagccccuuuggacaaaugucgcugucaguguuacagauu


 


ucuuuuauuggguuguuuuuuuguuguauuuuuuugaaccuuaacuuauuauuuuuuuuauauuuauuguuagaaaaug


 


acuuauuucugcucuggaauaaaguugcagaugguuca


 









168
X04663
Sequence below.







ccaaaaaccuuaauuuucuuucuuguucgguaccuacauuggaaccaccaaaaacaauuauuucaguaaaccguagccauga


 


gggaaaucgugcacauccaggccggacaguguggcaaccagaucggugcuaaguucugggaggucauaagcgaugaacaugg


 


caucgaccccaccgguaccuaccacggugacagcgaccugcagcuggaccgaaucucuguguacuauaaugaagccacaggu


 


ggcaaguaugucccucgagcuaucuugguggaucuagaaccugggacuauggacuccguucgcucagguccuuuuggccag


 


aucuucagaccagacaacuucguuuucggucagucuggggcaggcaacaacugggcuaaaggccacuacacagagggagcug


 


aguugguugacucugucuuggauguggugcggaaggaggcggagagcugugauugccugcaaggcuuucagcugacccac


 


ucacuggguggaggcacuggcucuggcaugggcacccugcucaucagcaagauccgggaagaauauccugaccguaucauga


 


auaccuucaguguggugcccucgcccaaagucucugauaccguggucgagcccuacaaugccacccugucuguccaucaguu


 


gguugagaacacggaugagaccuacugcaucgacaacgaggcccucuacgacaucugcuuccguacccucaagcucaccacgc


 


caaccuacggagaccugaaccaucucgucucggccaccaugagcggcgucaccaccugccuccguuucccgggccagcuuaau


 


gcugaccuucgaaagcuggcugucaacauggugccauucccacgucuccacuucuucaugccuggcuuugccccucucacca


 


gccguggaagccagcaguaccgggcccucacugugccugaacuuacccagcaggucuucgaugccaagaacaugauggccgc


 


cugcgacccgcgccacggccgguaccucacaguugccgccgucuuccguggacggauguccaugaaggagguggaugagcag


 


augcucaacgugcagaacaagaauagcagcuacuucguggaauggauccccaacaaugucaagacagcugucugugacaucc


 


caccgcguggccucaagauggcagucaccuucauuggaaacagcacagccauccaggagcuguucaagcgcaucucugagca


 


guuuacggcuauguuccgccggaaggcuuuccuccacugguacacgggugagggcauggacgagauggaguucaccgaggc


 


ugagagcaacaugaacgaccuggugucugaguaccagcaguaccaggaugccaccgcggaagaggaagaggauuucggagag


 


gaggcagaagaggaggccuaacggcagagagcccugcaucagcucaggcugcuuagaucccucagccuuucuccaacugccc


 


uuuguccuccaguuucuuucugcugccucugucuuguauuuguuuugcuucuguuuucucauuggggguaaauggugcc


 


uggcacauggcaggcacucaauaaauauuuguuugugg


 









169
X61232
Sequence below.







ggcagacaaaagaggccggcagugcagcucgcgggacgcauggccgggcgcggaggacgggugcugcuggcgcugugugcc


 


gcgcugguggccggcggguggcugcugacgcgugaagcccaggagcccggggcgccagcggcuggcaugaggcgccgccgg


 


cggcuccagcaagaggacggcaucuccuucgaguaccaccgcuauccagagcugcgcgaggcgcuggugucgguauggcugc


 


agugcaccgccaucagcagaaucuacacagugggcgccagcuucgagggccgggagcuccuggucaucgagcugucugacaa


 


ccccgggguccaugagccgggugaaccugaauuuaaauacaucgggaacaugcauggcaaugaggcgguuggacgggaauu


 


gcucauuuucuuggcccaguaccuguguaacgaguaccagaaaggcaaugagacaauugucaaccugauccacagcacccga


 


auucauaucaugcccuccuugaaccccgacggcuuugagaaagccgcauggcagcccgggcagcugaaggacugguuugugg


 


gccgcagcaacgcccagggaauagaucugaaccguaacuucccagaccuggacaggaucguauauguuaaugagaaagaagg


 


cggucccaacaaccaccugcugaagaaucugaagaaaauuguggaccaaaauucaaagcuugcccccgagaccaaggcuguca


 


uucacuggaucauggacauucccauuugugcuuucugccaaucugcacggaggagaccuuguggcuaauuacccauaugaug


 


agacacggagcgguacugcucacgaauacaguuccugcccugaugacgcaauuuuccaaagcuuggcucgcgcguacucuuc


 


uuucaacccagucaugucugaccccaaucgaccucccugcugcaagaaugacgaugacagcagcuuugaugauggaacgacc


 


aaugguggugcaugguacagcguccccgguggaaugcaagacuucaauuaccugagcagcagcaacugcuuugagaucacug


 


uggagcuuacgugugagaaguucccaccugaagagacucucaaaagcuacugggaagauaacaaaaacucccucaucaacuac


 


cuggagcagauacaccgagguguuaaaggguuuguccgugaccuucaggguaacccgaaugccaacgcaaccaucucugugg


 


augggauagaccaugaugucaccucggcuaaggauggggauuacuggcgauugcuugcuccuggaaacuauaaacuuacag


 


ccuccgauccuggcuaccuggcaaucacaaagaaaguggcaguuccuuuuagcccugcuguugggguggacuuugagcuug


 


agucuuucucugaaaggaaggaggaggagaaggaagaauugauggagugguggaaaaugaugucagaaacuuugaauuuuu


 


aagaaaggcuucuaacuaauugcuuucaucuaucuauagacuguaguaagaugcaauguggcucuuuucuuuuagguugug


 


ugcaguugauauuuaacauugauuuauuuuugaucauuaaguaauaguuacuaaucacguaaauacacccggacagaaaua


 


uaaugcuggacaucuucauucuacaucaacauucgcuuaaaucauucgaagccucuuuuaacguaaugggugacaaugucac


 


uugacagaugcaugagagucacgauauagcugacugugacccugcacugcaaucacauaguuccauauaaguuguccuuagu


 


cucuugugcugauucacuguauaagcaugauccugguaaugcacuuuggaugggaagaaaauguacgugcuuuucagaggg


 


gcucugaacagaaugaaaaccuaguucuugcguguacuuugaagaauggaauuguauuagucagcuguuaaugccacuuca


 


gaaguuugggguuuugucuugauuguagauugg


 









170
X14309
Sequence below.







gccacggacgccucucugaacggggauccaggcaggauuagagcugccucacugacuacaggccgugucgugucaccguuuc


 


ugcaggcaccaugagccaggacaccgaaguggacaugaaagauguggagcugaacgagcuagaaccggagaagcagcccaug


 


aaugcagcggacggggcggcggccggggagaagaacggucuggugaagaucaagguggcggaggacgagacggaggccggg


 


gucaaguucaccggcuuauccaaggaggagcuacugaagguagcgggcagcccuggcugggugcgcacccgcugggcgcug


 


cugcugcucuucuggcucgguuggcugggcaugcuggcgggcgccgugguuaucaucguucgggcgccgcgcugccguga


 


gcugccuguacagaggugguggcacaagggcgcccucuaccgcaucggcgaccuucaggccuuuguaggccgggaugcggg


 


aggcauagcuggucugaagagccaucuggaguacuugagcacccugaaggugaagggccugguguuaggcccaauucacaa


 


gaaccagaaggaugaaaucaaugaaaccgaccugaaacagauuaaucccacuuugggcucccaggaagauuuuaagaccuuc


 


uacaaagugccaagaaaaagagcauucacaucauuuuggaccucacucccaacuaccagggccagaaugcgugguuccucccu


 


gcucaggcugacauuguagccaccaaaaugaaggaagcucugaguucuuggcugcaggacgguguggaugguuuccaauuc


 


cgggaugugggaaagcugaugaaugcacccuuguacuuggcugaguggcagaauaucaccaagaacuuaagugaggacagg


 


cuuuugauugcagggacugaguccucugaccugcagcaaauugucaacauacuugaauccaccagcgaccugcuguugacca


 


gcuccuaccugucaaauuccacuuucacuggggagcguacugaaucccuagucacuagguuuuugaaugccacuggcagcca


 


auggugcagcuggagugugucgcaagcaggacuccucgcagacuuuauaccggaccaucuucuccgacucuaccagcugcug


 


cucuucacucugccagggacuccuguuuuuagcuacggggaugagcuuggccuucagggugcccuuccuggacagccugcg


 


aaggccccacucaugccguggaaugaguccagcaucuuucacaucccaagaccuguaagccucaacaugacagugaagggcca


 


gaaugaagacccuggcucccuccuuacccaguuccggcggcugagugaccuucgggguaaggagcgcucucuguugcacgg


 


ugacuuccaugcacugucuuccucaccugaccucuucuccuacauacgacacugggaccagaaugagcguuaccugguggug


 


cucaacuuccgagauucgggccggucagccaggcuaggggccuccaaccucccugcuggcauaagccugccagccagcgcua


 


aacuuuugcuuaguaccgacagugcccggcaaagccgugaggaggacaccucccugaagcuggaaaaccugagccugaaucc


 


uuaugagggcuugcuguuacaguuccccuuuguggccugauccuuccuaugcagaaccuaccacccuccuuuguucucccc


 


aggccuuuuggauucuagucuuccucuccuuguuuuuaaacuuuugcagauuacauacgaauucuuauacuggguguuuu


 


ugucuucaaauaaaaacaucaccccugccucaug


 









171
U42386
Sequence below.







gncuuaagccncguuuauuuugaugnccuguuggcucagunaugnccaagaugccnauuguuuuugcccnuaaauaaauuu


 


acugaacuugggcuaaaaccaaaccuuggcacacaggugugauacaacuuaacaggaaucaucgauucauccauaaauaauau


 


aaggaaaaacucaagugguagccugucuuaaggcuuuugauacuugcagauuggggaaaaacaaacaacaaacgucuugaag


 


cauauuaauggaauuaguuucuaauguggcaaacuguauuaaguuaaaaguucugauuugcucacucuauccuggauaggu


 


auuuagaaccugauaauagucuuuaaacaagccauuccagucaugaugaggugauguauggauacaugcauacauucaaagc


 


acuguucucaaaguuaaugcaaguaaauacagcaauuccucuuucaauguuuaggcagaucguuaacuaugagcuagccaaa


 


ugugggcauguuauuacagggaaaguuuaaaggucugauaacuugaaauagguuuaggagaauucaucuacuuagacuuuu


 


uaaaugccugccauaaaaaauugaaaugguagaauggcugaccacagcaaugaccagcccucaccuagggcucuggaugauu


 


uuuggucuaauaacgcaugcuaguguugauguuuuuuggucaagaugggaaugaacaggaagaauuaugcagcaggcuuua


 


uuuuaaaugccgauucacauuacucuguucaagcugcguugagauguuaaacuggcuuacuauagacuuuguaaaaaaaaa


 


aaaaaccaaacaaauggcuccagaagaguaacaaacugaaaucugagaucacacagguuggaaauauguacauaacugaacaa


 


ggugucaauucugcucuacagugcaguuuagucaguuuuaguugcauagguuuccauuguuuuuauagucuguuuaugcu


 


aaaucuggccaaagaugagcauuguccaccacuaaaaugccuaugccacugggaauucuggguuaauuuugugaccagaaug


 


cagugaucaaaauguucaaucuuuuuacaguggcauaggaagauggcaaaaauuuccuaaagugcaauagauuuucaagug


 


uauugugccuuguucuaaaacuuuuauuaaguaggugcacuugacaguauugaggucauuuguuauggugcuauuucaau


 


uagucuagguuuaggcccuuguacauuuggcccauaacuuuuuacaaaguacuucuuuuauugcacauucagagaauuuua


 


uauauaugucuugugugcguguccuuaaacuuccaaucuuauuuugucucuuggagauuguugaacgcagcuugucuagg


 


aaagggaugggacuagauucuaaaauuuauuugggaccaugggaaugauaguugggaagaaacuuugcacacgacagauuu


 


cuagauacuuuuugcugcuaguuuuauguaauauuuauugaacauuuugacaaauauuuauuuuuguaagccuaaaagug


 


auucuuugaaaguuuaaagaaacuugaccaaaagacaguacaaaaacacuggcacuugaauguugaaugucaccguaugcgu


 


gaaauuauauauuucgggguagugugagcuuuuaauguuaagucauaauaaacucuuaagucaaauuaagcagacccggca


 


uuggcguguagccauaacuuucugauguuaguaaaaacaaaauuggcgacuugaaacuaaaucaugccaagguuugauacac


 


uugucuugagauauuaacgaaacacuuccaaacacugauacaaaguguccagauucucagauguuuguugugugaguuuug


 


uuuaguuguauuuuuuuuucagugaaugucuggcacauugcaauccucaaacaugugguuaucuuuguuguauuggcaua


 


uucagugacuuguacauucagcaauagcauuugagcaaguuuuaucagcaagcaauauuuucaguuauguuuccaaauuaa


 


gaauggguuuaaacuugcugaauguaaagauugacccucaagucacuguagcuuuaguaguugcuuauuguauuaguuua


 


gaugcuagcacugcaugugcugugcauauucugguuuuauuaaaauaaaaaguugaacugcacagucuccuuuguuguugu


 


caauugugguuuacuuuuagaggugaaaauaaaguugugcucuugccucgugccaauauguacauaacugnacaagguguc


 


aauncugcucuacagngnaguuuagncaguuuuagungnauagguucccaunguuuuuaungncuguuuaugcuaaaucu


 


ggccaaagaugagcauugcccaccacuaaaaugccuaugccacugggaauccuggguuanuuuggngaccagaaugaaguga


 


ncaaaauguccanucuuuuuacaguggnauaggaagauggnaaaaauunccuaaagugnaauagauuuccaaguguuungu


 


gccugguncuaaaacuuuunuuaaguagggugcacunganaguauugaggncauugguuauggugcuauuuccanuuagu


 


cuagguuuaggcccu


 









172
U51126
Sequence below.







cucggucuccaagaugguggcuaacaaaacgugaggccuagagguugauccuaggucacuggaagcauguccuugaagagg


 


acuaugggcaucuggguucuuccucuucuacuuggccacgagguaaccggcuucuuguaccacgugugcucaccucuacaa


 


ucugugcggauucagacuccaagcaacuaggcuacccagugacaggcuaaaaacuacagcucuaacgucuuggaaggcgauu


 


ccauggaccaggauguggaaagcccaguggccauucaccagccaaaguugccuaagcaggccagggacgaccugccgagacac


 


aucagccgagacaggaccaaaaggaaaauccagagguacgugaggaaggaugggaagugcaacguucaccacggcaaugugc


 


gggagacguaccgauaccugacggacaucuucaccacccugguggaccugaaguggagauucaaccuguugaucuuugucau


 


ggucuacacagugacguggcuuuucuuugggaugaucugguggcugauugcguacauccggggagauauggaccacauaga


 


ggaccccucguggacuccuugugucaccaaccucaacggguuugucucugcuuuuuuauucuccauagagacagaaaccacc


 


aucgguuauggcuaccgggucaucacggacaagugcccugaggggauuauucuccucuuaauccaguccguguuggggucc


 


auugucaacgccuucaugguaggauguauguuugugaaaauaucccaacccaagaagagggcagagacccuggucuuuucca


 


cccacgcggugaucuccaugcgggaugggaaacugugcuugauguuccgggugggggacuugaggaauucucacauugugg


 


aggcauccaucagagccaaguugaucaaguccaaacagacuucagagggggaguuuauuccccucaaccagacugauaucaac


 


gugggguacuacacaggggacgaccggcucuuucuggugucaccauugauuauuagccaugaaauuaaccaacagagucccu


 


ucugggagaucuccaaagcgcagcugccuaaagaggaacuggagauuguggucauccuggagggaaugguggaagccacag


 


ggcaguucugaaaucgaaaucaagcagaggucuauaagaacacccuggagacccccaugcugcuggaucuuggguccaugaa


 


cugcuuuuauuugcugcaaucaaaaaugcuagucgcugaucugauaggagaggaaacgagacucagagccugaaggauaaca


 


cgcugagggcugauuucauacacucuucccggcuggaucaucccagcccccacagcguccaggcuuaguuucuuccuuugu


 


uuuaacaaucuauacuuccuccagccugggcgagcuaguauacccagaguuugguuuuguuucuuuucagagcuguaagcc


 


cagugcccagugaccucaucugggaggagaguuaagcaauaagaccugaaugcuaacucugggguagaaaaccucugcag


 


agacagcgucucugggaagucucuacagagacagaguagggaagucucacgaaggucagagucuuacuuccauaccuggaga


 


aauccgcccguccguucagugccgguuucaacuccucugccaaagacuucuuuccaagacacugguaucagcuaucccagca


 


guaacuuuggcaguauauaaaucaauggcacugccccauaaaaccccguugaguaaaaccuauggucuucaacagcugggga


 


gccuguagcccagcuccugugugaggcuaaggcuguggagaccaugccugcucaccuccucguugaaaagcaaaacacugua


 


agaaaccuaacaugacuuuuuccaacauuucucaggcuggggagaagacuugguccacaaagagcuugaggucuugaucug


 


gaucccuagcauccauggaagaaggugggcaugaucacccacacuccucaucccauagcucugaaugagguaggcagauucc


 


uggggcucaccagcucauccuaacagccaggucccaaugagggacugucuacaaaagaacaagagguggauccugagaagcg


 


acacccaagcuugaccucuagccccuguacacaccuguuaagcaccugggcaucgggacacacacucgcaauuugcaaacaag


 


gcaaauucucacacuucagaaggcacugagagaaucccauaagcucaaaaaguuaggagccaagauugaccauuaaugacuu


 


ggguugaaaagacuaaaccacuggauagaauguuucauuacuaaaacaccuuaccugaaaaguauuacugcucuucuuucug


 


caacuggaccaugcagagauccacaaagagaugcccagagauuauuagugauggucauaugauauacacaauguggacucua


 


agccaaggccccaucaacucagauccagaggcugacagugugcuuaucuuagagauaccacaguggcugccuaaucaccacg


 


uccuuaagucaggggaguuugauuauuuccuaugaacaccgaguggggacagcggauuaccaaugaagcaauccaaccugac


 


aauccuaaccacccagaagaggaucgcugggggaaagcaugaauuauuuacgugucaacaugugcacacuccggccacgcag


 


cucaacagccaggagugcuucuccacuuagcccugcccuggcauccauuuaugaucucgucuguuguguuaauuacccagcu


 


agcuuuuuucucaaaaauaauaucucccagccauagaccuacucaucuguguccucuuuaauuucaacccacaguuacauca


 


uucacuggcuugcucaguuucuucaacucugaaaugggaaugaugaugaugaugccucuuccccccaagccaccauccucccc


 


cgugaccuuccuagguacagacucaaaccagggaagauuauuuccuucucauaggccacagggugaaaugcaauaaagaaca


 


aagccuuguagggaggcagagggaaagaccaguccucacaagaggcuccauuguuuccagggacuuugaagcuuggacagaa


 


ugucagaugauccccuuugaaggugcuccaaagagucaaugugaaaaauauugacugaugugugcccuccacaagccaagg


 


ugccucugcccuggucaccuaccaugaauuauaaacugaugauauuugaaauaauaaggaacacuggagccggccagaaagg


 


auucugcagucccauaaauagcaacauucaucacuacaaugccugccaacgguggccgugaauguagauuacccccggcucu


 


ucugaggccacugaggacagggcaaacuaccucugagaauggaggcucacuguucugcaucccacuucuaaauguuccauga


 


auuuuuugagacaucucccauaucccuguuagaaagauucaaccuugugcuauuaaccaaaucauuuugaauuccauaaacc


 


ucuacucuaaaguauacacuuaauucuacaauacagacaacaaauaugacuuuuuccuaugaaagagugauaaagauacugu


 


aucagucugcuuugacucaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa


 









173
AF093853
Sequence below.







uggaaugggugcuaggugaaggcuuuguugaaucaggaugcugagcugguguuuuuacagguccagauaugaugagcugg


 


aguuuugguaggcccagguaccuccuccaaaauugaccacauaauuggucacaaaucaggccuccacagauacaaaaauauu


 


gaaauuaucccaugcauccugucugaucaccacagacuaaggcugaucuucaauaacaacauaaaaauagaaagccagguuca


 


cugcugcggcugcgccuccuuguucucagcgucaccacugccgccaugcccggaggguugcuucucggggacgaagccccca


 


acuuugaggccaauaccaccaucggccgcauccgcuuccacgauuuccugggagauucauggggcauucucuuuucccaccc


 


acgggacuuuaccccagugugcaccacagaacuuggcagagcugcaaagcuggcgccagaguucgccaagaggaauguuaag


 


uugauugcucuuucaauagacaguguugaggaucaucuugccuggagcaaggacaucaaugcuuacaauggugaaacaccca


 


cggaaaaguugccauuucccaucauugaugauaagggcagggaccuugccauccuuuugggcauguuggauccagucgaga


 


aggacgauaacaacaugccugugacggcccgugugguguucauuuuuggcccugacaagaaacugaagcugucuauccucu


 


acccugccaccacgagcaggaacuuugaugagauucucagagugguugacucucuccagcugacaggcacaaagccgguugc


 


caccccaguugacuggaagaagggagagagcgugaugguaguccccacccucuccgaagaggaagccaaacaauguuucccu


 


aaaggagucuucaccaaagagcucccgucuggcaaaaaauaccuccguuauacaccccagccuuaagucuuugcggaaauug


 


gggcugcaucugcacguccagcacuggggccugaggacgucagccggcagccguggguccuugcagcagguccguagaaaga


 


ucguggcaugaucacagccggccuguagaucgcucgcuauacuacugggucauuaaauggaaauggcaccaaaaccuucuc


 


gggauucuuuacucugugccuucgccagcauucugccccucugccugucacagugcccuacugacuggcucucuuugaaac


 


gaauuauguauugaagauuccuuaggucucugcagggucuuugaucagcaagcaagguagcagugugggcucugugc


 


uagaaugaugaaacaccuuuuguagcuuuccgaacggaaucuucuguuacccauuuuggagagcacugacauggggagaag


 


cuuucaauucuguauuuuuaguaaauaaaguggggacagccgggagaauucuuacagggaaucuauuguaaguuucuaucg


 


aagugggcucagaaagccuuucgccucccaagagugcgcauguaccuccuagaguuuccacaucugcucucuggugauguc


 


ugccugugaacgcaccuuauaagacgggcggugacaguguuuuaccacucagugccuaguaguggguggccauuucug


 


aauucugcuuuuugagguucaacaaauaaaauccugaucagaaaaaaaaaaaaauagaaagccaacauucauguggaaacuga


 


acaacacuacucaaugauuccuuggucagagaugaaauaaagaaagaaauuaaagacuuuuuagaguuuaaugaaaaugaag


 


ccacaacauacccaaacuuaugggacacaaugaaggcauuucuaagaggaaaacucauagcccugagugcauccaaaggaaaa


 


aaaaaaaaaccuagagagaguguacacuagcagccugacugcacacuuagaagcucugcaaaaaaaggaaucaaauucaccca


 


agaggaauagacagcaggaaauaaucaaacuuagggcugaaaucaaccaaauggaaacaaaaagaacuauucaaagagugggc


 


caaaccaggagcuaguucuuugagaaaaucaacaagauagauaaacccuuagccagacucacuagagggcacagggacagcau


 


ccuaauuaacaaaaucagaacugaaaagggagacauaacaacagauccugaagaaauccaaaacaccaccagauccucuacaaa


 


aggcuauacucaacaaaacuggaaccuggaugaaaggaaaagcuucuagacaga


 









174
Z19521
Sequence below.







augagcaccgcggaucugaugcgucgcugggucaucgcccugcuccuugcugcugccggaguugcaguagaagacucaggc


 


agcaggaacgaguuccaguguagagacggaaaaugcaucgcuagcaagugggugugcgauggcagccccgagugcccggaug


 


gcuccgaugaguccccaaagacaugcaugucugucaccugucaguccaaucaauucagcuguggaggccgugucagccgaug


 


cauuccugacuccuggagaugugauggacagguagacugugaaaaugacucagacgaacaaggcuguccccccaagacgugc


 


ucccaggaugacuuccgaugccaggauggcaagugcaucuccccgcaguuugugugugauggagaccgagauugccuagau


 


ggcucugaugaggcccacugcccagccaccacuuguggccccgcccacuuccgcugcaaaucauccauaugcauccccagucu


 


uugggccugcgacggggaugucgacuguguugacggcucccaugaguggccacagaacugccaggccgaagacacggccucc


 


aaaggcguuagcagccccugcuccucccuggaguuccacugugguagcagugaguguauccaucgcagcuggucugugac


 


ggcgaggcgacugcaaggacaagucagaugaggagcacugcgcgguggccaccugccgaccugaugaauuccagugugcag


 


auggcuccugcauucacgguagccgccagugugaccgugaacaugacugcaaggacaugagcgacgagcucggcugcgucaa


 


ugugacacagugugauggccccaacaaguucaagugucacaguggggagugcaucagcuuggacaaggugugcgacuccgc


 


ccgcgacugccaggacuggucggaugagcccaucaaggagugcaagaccaacgaguguuuggacaacaaugguggcuguucc


 


cacaucugcaaggaccucaagauuggcucugagugccugugucccagcggcuuccgguugguggaccuccacaggugugaa


 


gauauugacgagugucaggagccagacaccugcagccagcucugugugaaccuggaaggcagcuacaagugugagugccagg


 


ccggcuuccacauggacccacacaccagggucugcaaggcugugggcuccauaggcuaucugcucuucaccaaccgccacga


 


gguccggaagaugacccuggaccgcagcgaguacaccagucugcuccccaaccugaagaaugugguggcucucgacacggag


 


gugaccaacaauagaaucuacugguccgaccugucccaaaaaaagaucuacagcgcccugauggaccaggccccuaacuuguc


 


cuacgacaccaucaucagugaggaccugcaugccccugacgggcuggcgguagacuggauccaccgcaacaucuacuggaca


 


gauucagucccaggcagcguaucuguggcugacaccaagggcguaaagaggaggacacuguuccaagaggcaggguccagac


 


ccagagccaucguaguggacccugugcauggcuucauguacuggacagauuggggaacacccgccaagaucaagaaaggggg


 


uuugaaugguguggacauccacucacuggugaccgaaaacauccaguggccaaauggcaucacacuagaucuuuccaguggc


 


cgucucuauuggguugauuccaaacuccacucuaucuccagcaucgaugucaaugggggcaaucggaaaaccauuuuggag


 


gaugagaaccggcuggcccaccccuucuccuuggccaucuaugaggacaaaguguauuggacagaugucauaaacgaagcca


 


uuuucagugccaaucgacucacggguucagaugugaauuugguggcugaaaaccucuuguccccggaggacauuguccugu


 


uccacaaggucacacagccuagaggggugaacuggugugagacaacagcccuccuccccaauggugguugccaguaccugug


 


ccugcccgccccacagaucgguccccacucgcccaaauucaccugcgccugcccugauggcaugcugcuggccaaggacaugc


 


ggagcugccucacagaagucgacacuguacugaccacccaggggacauccgccguccggccuguggucaccgcaucagcuac


 


caggccaccgaagcacagugaggaucucucagcucccaguacuccuaggcagccuguggacaccccagggcucagcacagugg


 


cgucagugacagugucccaccaaguccagggugacauggcuggcagagggaaugaggagcagccacaugguaugagguuccu


 


guccaucuucuucccuauugcacugguugcccuccuuguccuuggggccguccugcuguggaggaacuggcggcugaagaa


 


caucacaaucaacagcauaaacuuugacaacccagucuaccagaagaccacagaggacgagcuccacauuugccgaagccagg


 


auggcuauaccuaccccucaagacagauggucagccuggaggacgauguggcaugagcagccgggagagccgucucuuuccg


 


ggauccauugccaagcuuaggcagaaaagacacucucuccagaccuccccauccagcacugguccugccaccucccugggucu


 


guguugcucaaagcaagauagagcaaagcugggcuggggggccaagcucagcuuccugucugccccagguucuguuuuaua


 


uauuuauugucugggacagaaaaggcuacuggcugugcuugaaauucga


 









175
U04354
Sequence below.







accggucaucgggcucuuccuugggcucagggcacggaucaaguccucggcucgcucggccagcaccgcggcaccauggcgc


 


aggagcugcagcaccccgaguucgcgcgcgcaggccagcaggcugggcugcagguguggagggucgagaagcuggaacugg


 


uaccggugccccagggugccuauggugacuuuuacgucggagagcccuaccuggugcugcacaccaccaaguccagcagggg


 


cuucuccuaccgccugcauuucuggcugggaaaggaguguucccaggaugagagcacagcggcugccaucuuuacggucca


 


gauggacgacuauuuggguggcaagccaguccagagcagagagcuucaaggcuaugagucgacugauuuugugggcuauuu


 


caaaggcggucugaaguacaaggcuggagguguggcuucuggacuaaaccauguccucaccaaugaucugacugcgaaaaga


 


cuucugcacgugaagggucggagaguggucagagccacugaaguuccccucagcugggagagcuucaacaagggcgacugcu


 


ucaucauugaccuuggcaccgaaauuuaccaguggugugguuccuccugcaacaaauaugagcgucugaaagcaagccaggu


 


ggccauuggcauccgggacaaugagaggaaaggaagaucucaacucauugugguggaagaaggaagugaaccaucagagcuc


 


augaagguuuuagggagaaagccugagcuuccagauggggacaaugaugacgaugucguagcagacauaaguaacaggaaga


 


uggcgaagcucuacaugguuucagaugcaaguggguccaugaaaguaacacugguggcugaagaaaacccguucuccaugg


 


gaauguugcuuucugaagaaugcuucauuuuggaccauggugcugcaaaacaaauuuuuguauggaaagguaaaaaugcua


 


acccacaggagaggaagacugccaugaagacagcugaggaguuuuuacagaaaaugaaguauucuacuaauacucaaauuca


 


gguucuuccggaaggcggugaaacaccaauuuucaaacaguucuuuaaggacuggaaggauaaagaccagagugauggcuu


 


ugggaagguguacaucacggagaaaguggcucagauaaagcagauuccguuugaugccucaaaacugcacaguucuccgcag


 


auggcagcccagcacaacaugguggacgauggcucuggcgggguggagaucuggcguguagagaacagugguagaguccag


 


auugacccaagcuccuauggcgaguucuauggcggugacugcuacauuauccucuacacuuaucccagaggacagaucaucu


 


acacauggcaaggagcaaaugcuaccagagaugaacugaccauguccgcguuucugacuguccaguuggaccggucccuugg


 


agggcaggcugugcagguccgugucucucaaggcaaagagccugcucaccugcugaguuuguucaaagacaaaccacucauu


 


auuuauaagaaugggacauccaagaaagaagggcaggcaccggcucccccuacacgccuuuuucaaguccggaggaaccugg


 


caucuaucaccagaauuguggagguugacguugaugcaaauucauuaaauucuaaugacacuuuuguccuaaaacugccacg


 


aaacaauggcuucaucuggauaggaaaaggugcuagccaggaggaggagaaaggagcagaguauguggcugauguccucaag


 


ugcaaagcuucaagaauucaagaaggcaaggaaccagaggaauucuggaacucucuuggagggaggggagacuaccagacuu


 


caccauugcuagaaacucgggcugaagaccauccaccucggcuuuaugguugcuccaacaaaacuggaagauucauuauuga


 


agaaguuccgggagaguucacccaggaugaccuggcagaagaugaugucaugcuacuugaugcgugggaacagaucuuuau


 


uuggauuggcaaagaugccaaugaaguugagaaaaaggaaucagugaagucugccaaaauguaccuggagacagacccuucu


 


ggaagagacaagaggacaccgauugucaucaucaagcaagggcacgagccccccacauucacaggcugguuucugggcuggg


 


acuccagcaggugguaaaaccagcaacuauccuggcugcauuggggcagcugccacuuuguuguuggggaauuguuuacuu


 


uuuguuauuggcuuuugaagauaaacuccugccaaauggauauauaucuauaucuauaucuauaucuauaucuauaucuau


 


aucuauaucuauaucuauaucuaucuauaucuaaucuauaucuaucuaucuaucuaucuaucuaucuaucuaucuaucuau


 


cuaucuauaugcuccucuuuuccuucucuuucaaagggaauugcuguauguuacuauacugaaauaaccuaaagcaaccauu


 


uguuuucgagcaauuuugcaaucuggggaccucugaggaaguaauuuugucauucagccacugcuagccaaacuugucuuu


 


ucccauagagaggaaggagagccacagugcuucuaagcauuuccccgucugcauacucuguuugcagugagcuuuacuuuau


 


guauggcuuuaacaaugccuugcuguuucccaucucaagucaaugccacuucggaugccauucacucccaaguguccuuacau


 


aggaugaacuucuuuagcuuuuuuagaaaacuaaaaucaugucuuuuaugauaaaacacauuuuauuucuauaaguuuaac


 


uuuauauauuugauagcacaugcucaauagcauaaagaauaugcauugaaugauguuuuucauaauuaaaauauauccuuu


 


ugg


 









176
M35244
Sequence below.







caggguugagagcaagaaggugcaggauguaggccagcagaauuaucagacccaguggcggcuucugccacuggaagaauuu


 


ccaacauaaaacagaugaucaguuugggacaaucgauucugcgaccagagguagugucaucugguuacuuuuaaaauucaga


 


uugucugguguuuuccaaucacucgcgacuguaauuugaaguuggauucugagauaauacaaucgcugucgcucuaguuua


 


uaaagcuguccaagaucugcccagucccagauguccuggguccucagggcggcuguggucugcgcccuucuccugcagcug


 


gaugccagaccauccuggacucggaucccuuuggguucacacucgcuuagguauuucuacaccgcugugucccggccuggc


 


cuuggggagcccugguucauaaucgucggcuauguggacgacaugcagguccugcgcuucagcagcaaggaggagacuccg


 


aggauggcacccuggcuggagcaggaggaagcagaugacugggaacagcagacucauauagucacaauucaaggacagcugu


 


cugaaaggaaucugaugacccugguucauuuuuacaacaagagcauggacgacucucacacacuacaguggcugcaggacug


 


cgauguggagccagaucggcaccugugucucugguacaaccagcucgccuaugauagcgaggaucuccccacccugagcgaa


 


aacccaaguuccuguacagugggaaacagcacuguaccucagaucucucagcaccuggagggccacugcucagaugugcugc


 


agaaauaccuggaaaaagggaaggagaggcugcugcguucagaccccccaaaggcacaugugacccgucaccccagaccugaa


 


ggugaugucacccugaggugcugggcccuggguuucuacccugcugacaucacccugaccuggcagaaggauggggaggag


 


cugacccaagauguggaguuuguggagaccaggccugcaggggauggaaccuuccagaagugggcagcugugguggugccu


 


cuuggaaaggugcagaguuacacgugccauguggaccaugaggggcugccugagccccucacccugagaugggagccugcau


 


gguaccaaaagccuuggauuuggauuguugccacgguuuuuuccauuuugcucauuugucucuguguggcucgcagaccca


 


ugaagaagaaugcaggugggagaggaaggcgugacacccaagaagcaggcagagacaguccccaagacucuagcaagacugu


 


uguggaugaugaggagauggggguuugcuuuuggaagauuaaguccuguaaaacuugucuaggccacuccccaggaacuuc


 


aggaucaucugggagaugccccuuugaguggcugggcugugaggacagcaggccaguucuugccacccuggacagaaacaca


 


ucucaccuuucuggcucgaggaucugaacaccugucucuugccuacucggcuucuagucaggcauuuugucaccuugucaa


 


gggucccagggacacaaagcucccuccucucacccacagcacucuggguccuacccccaaugcuucagggacauuuaaucagg


 


ucaaauugggaucaauggcuuugaugcagaaaagaacuguggacuaauagagauaggguuuaauaaaaaaaauaucuuuuu


 









177
AW121930
uuuuuuuuuuuuuuuuucaacuuuaaagacuggauuugagguucagucugggucucuggg




ggggaccucugucaucacgccuauaaucaucccgagaguagucaucccuggagcuccacg




accgaucaucccgucugucauagcggucuucauagcgguccccaccuccucuguagucau




caucucuccgguacccacuuccaaaugcccuucugccacugccuauccuggagucauagc




cucggucauagucucugcugccucggucaucauagcgaucccggcccccauagcggucca




ugucucugcgugggccgucccgauauccgucccuauacccaucccgauaccggucugaau




cguaacgaucucgauacuugucuccaaagcuaucaucgccucuucuagguggguagucau




cacaacugucuguggugggacgggcccuccagucugugucuguuuug


 


178
AI852632
uuuuuuuuuuuuuuuuuggcccccaggcucugucucaaggaugggaauagaucaagccaa




acagugaaaaauaaggcaaaucguggcuucgggguuugagacuggcaccaauggcaaauc




agcagaggagaugcaaaugggguaacaaucacaguuagugggguaacaugagcaggcagg




aaacccuugagacaacacccaagguccacgucuucgcaugugcagggcacaacuccagca




gcaguuucugggcuuggaggcuuguuacucuuccuaccuuucccacccccuaaaagacac




caagauggagcccacgaagagauuacaucaagcucuucuggcuggg


 


179
U70475
Sequence below.







ucuaggacagccagggcuacacagagaaacccugucucaacuaaaacaaagcaaaccccccgaauauuguuuuuuauuugcg


 


gaugucuguuuauugagacgggguucauggcagacaugagugucucagugcauuugcuauccucucuucuaaaggggcgg


 


gggggggggugcgcuggagagguggcucagcaguuaagagcacugacuucucuuccagagguccugaguucaauucccagc


 


aaccacaugguggcuuauaaccaucuauagugagaucugaugccuucuucuugccuguaggcagaccacuguauacauaaua


 


aauaaaucuuaaaaggggggggaagguguggagcuaaaaguauggcaauaugcauaaguuuagcuauuucuguuguuuugc


 


agucaucagugagccaaacuaauucgaauggguagcuagaucuuguugcuuuuagcgaauauauauugagugaauggaauu


 


gacagucuucuguauucucauucaguuuguuuguguucuuccccaucagugauaacauguagugaacuaacccguguggac


 


caucuuaaccauggcuucuccuuccuuuucuguuuuaaacauaggacauggauuugauugacauccuuuggaggcaagaca


 


uagaucuuggaguaagucgagaaguguuugacuuuagucagcgacagaaggacuaugagcuggaaaaacagaaaaaacucga


 


aaaggaaagacaagagcaacuccagaaggaacaggagaaggccuuuuucgcucaguuucaacuggaugaagaaacaggagaa


 


uuccucccaauucagccggcccagcauauccagacagacaccaguggauccgccagcuacucccagguacacucgucguggug


 


ggagcuaaggaaaacucuagugagaaagcagacucucuggaguugaguucuuggucugccauuuacugugucuuuugugag


 


gaggagaaguucucaaacuucgcuucuugauaaucaggacacagaucacagggaggacuuugugaguucagaaacauccucu


 


guggugaugaaacagcggcagaaauacuguugggaguaaaagaaguaggcauugcucauugugguaggcagggcccugauu


 


guauggguaacugacuuaacuguguuaaguaugauucccauuuuauauucccaugucuaaacaacuaaagcauuugcccag


 


aacacucagaaagaaaugaagggagguuauugccuagcacagagcccugguucagucccccacgcuguucguuaaaggggag


 


ggacuaauaauuugaacacaaucugguuugaaucuaugcaaaucgauuucugaaaugagaccauagguuauuuuaugaaca


 


agucuuauugcucguugugacccugugcuuagaacauuucauaaaugaugcucucugugccuuuccccuuccuccagguug


 


cccacauucccaaacaagaugccuuguacuuugaagacuguaugcagcuuuuggcagagacauucccauuuguagaugacca


 


ugagguauaaaaauguuuguuuaacagcaaaacucccuuaucugauauuaguuccuuucaugugucuccaauuaagagaag


 


aaaagaaaauuuuagaaggaaaaaauugaucaaagaaauugucaaguaaacuguaugagagcuauauaaugcuuaaaaauaa


 


gaccuguaugggcuggugagauggcucaguugguaagaguacccgacugcucuuccgaagguccagaguucaaaucccagc


 


aaccacaagguggcucacaacauccauaacaagaucugacucccucuucuggagugucugaagacagcuacaguguacuuac


 


auauaauaaauaaauaaaucuuuaaaaaaaaaaaauaaggccuguaaacuacaaguccauuuuacuguauagcuggaaacagg


 


aaucagaauaauuuucccuggaaacuggauauagauauauaaaauauuuugacuaguaaagaacaacuauuaaucagcauuu


 


ggauuaaaaaaucuuaaucuguuguuugaagcauucugcuagauauuauggguacagauuaaguccuaaugaauguuuuua


 


uccauuuugaagucugccuuuaaauacauggagugaaauaaccuaggaguguauuaauauggagucacugggaggaggaaa


 


uguuucauuuuauaaaagcagccugagagcuguaggcccugcugcugucuguucuucaugccuuggcucucacucacauga


 


aucaaugucacgucaaucuuggcuuucuucacuugcauuucagucgcuugcccuggauauccccagccacgcugaaaguuca


 


gucuucacugccccucaucaggcccagucccucaauagcucucuggaggcagccaugacugauuuaagcagcauagagcagg


 


acauggagcaaguuuggcaggagcuauuuuccauucccgaauuacagguaagagagcucuaggagugugcuguuuucugcg


 


ggcccuuuuaaauuagucauccuaguuauuuauuauuuacaugcuaccuccucaaaggaagaaauugaugguguauuuaaa


 


uuacucaugagagcuucccagacucacuuaacacacauaguuuuuagguaaucagacugaauauuucuggauaaauucauuc


 


aaagacugaaagcuaauuuagaguucugacaaagauaaaauacuuaucuauugaaaaaugggaguugaaggaauuauugaaa


 


agaacaccuuggauuuggggguagggaauugaucuaaaaugcacuuagccucugcucauacaaugugaccuucuuuccuag


 


ugucuuaauaccgaaaacaagcagcuggcugauacuaccgcuguucccagcccagaagccacacugacagaaauggacagcaa


 


uuaccauuuuuacucaucgaucuccucgcuggaaaaagaagugggcaacugugguccacauuuccuucaugguuuugagga


 


uucuuucagcagcauccucuccacugaugaugccagccagcugaccuccuuagacucaaaucccaccuuaaacacagauuuu


 


ggcgaugaauuuuauucugcuuucauagcagagcccagugacgguggcagcaugccuuccuccgcugccaucagucaguca


 


cucucugaacuccuggacgggacuauugaaggcugugaccugucacuguguaaagcuuucaacccgaagcacgcugaaggca


 


caauggaauucaaugacucugacucuggcauuucacugaacacaagucccagccgagcguccccagagcacuccguggaguc


 


uuccauuuacggagacccaccgccuggguucagugacucggaaauggaggagcuagauagugccccuggaagugucaaacag


 


aacggcccuaaagcacagccagcacauucuccuggagacacaguacagccucugucaccagcucaagggcacagugcuccuau


 


gcgugaaucccaaugugaaaauacaacaaaaaaagaaguucccgugaguccuggucaucaaaagccccauucacaaaagaca


 


aacauucaagccgcuuagaggcucaucucacacgagaugagcuuagggcaaaagcucuccauauuccauucccugucgaaaa


 


aaucauuaaccucccuguugaugacuucaaugaaaugauguccaaggagcaauucaaugaagcucagcucgcauugauccga


 


gauauacgcaggagagguaagaauaaagucgccgcccagaacuguaggaaaaggaagcuggagaacauugucgagcuggagc


 


aagacuugggccacuuaaaagacgagagagaaaaacuacucagagaaaagggagaaaacgacagaaaccuccaucuacugaaa


 


aggcggcucagcaccuuguaucuugaagucuucagcauguuacgugaugaggauggaaagccuuacucucccagugaauac


 


ucucugcagcaaaccagagauggcaauguguuccuuguucccaaaagcaagaagccagauacaaagaaaaacuagguucggg


 


aggauggagccuuuucugagcuaguguuuguuuuguacugcuaaaacuuccuacugugaugugaaaugcagaaacacuuua


 


uaaguaacuaugcagaauuauagccaaagcuaguauagcaauaauaugaaacuuuacaaagcauuaaagucucaauguugaa


 


ucaguuucauuuuaacucucaaguuaauuucuuaggcaccauuugggagaguuucuguuuaaguguaaauacuacagaacu


 


uauuuauacuauucucacuuguuacagucauagacuuauaugacaucuggcuaaaagcaaacuauugaaaacuaaccagacc


 


acuauacuuuuuuauauacuguaugaacaggaaaugacauuuuuauauuaaauuguuuagcucauaaaaauuaaaaggagc


 


uagcacuaauaaagaauaucaugacuuaaacuacuuuggacuuuuugaauuuauucacacuauuuuccauaggacaaucac


 


ucauuuaccacauuugguuauuuuacauuuucaaaauggguuugaaaauacagaggcauuuuauagccauguguggcaguc


 


caugauuuuuuauucccgacauucaggaggcagaagcaggcagaucccugggcuccaggacggccaaggcuacaugagagcc


 


ugucucaagaaagacaaacccuuucuauacuaaacguuagcuaggauugucaaggagaugguauauauccacaaugguaugc


 


cugcuguacaguacuguggcacagagaacaaaaccuguaaccuccuguguucuuagaaguggcauucuaagaagggcuagga


 


aga


 









180
U09659
ggccagcaggacucuccuugcagcagcggcccgaguucagaguccggagcugcgguggug




gcggcgaaggcgagagucauggcuggacaagcuuuuaggaaguuucuuccgcucuuugac




agaguauugguugaaaggagugccgccgaaacuguaaccaaagguggcauuaugcuucca




gaaaagucucaaggaaaaguguugcaagcaacggucguggcuguggggucaggagggaaa




ggaaagaguggagagauugaaccugucagugugaaaguuggagauaaaguucuucuccca




gaauauggaggcaccaaaguaguucuagaugacaaggauuauuucuuauuuagagauagu




gacauucuuggaaaguaugucgacugaaaucacuguugaaauggugucacgugaagcugc




cauuccacugaugucugaacuauuucaucauguaaauaauuu


 


181
AW124785
uuuuuuuuuuuuuuuuucaggucucauuuucguuuauuugaaauucggugcucguguaag




uuuuuucucuuccccucaaauuuuauuucaguaaaaggagacuugggcgagguggauacc




ccacagccggauucuucccccccugccccccaggguggcuaaugcuaucuggggaagucg




ucauagggaagagaacuaugggugggcuccugccugaggccuccaaucucagcccagugg




acauaucacaggcagcuuaaaaaaaaaacccuaaaaaaaacaccccaaaacacacauuua




aauagguauucaagacagcuuuaaaaaaugcacccacucacaccccccucccuuuucuuu




uuggaaaaaaaaauaggaaaaaaaaaaaaaccaaaccgaauucucgcuuggccucua


 


182
AF071315
Sequence below.







auuuggcuccgaggccaagaauucggauccaaggcgggcgcggggaaaauggcggcggcagcugcggcgggggcgaauggg


 


agcggaggcagcagcggcauggaaguggaugcagcaguccccagcgugauggccuccggagugacugggaguguuuccguc


 


gcucuucauccccuugucauccuuaacaucucagaccauuggauccgcaugcgcucccaggaggggcggccuaugcagguga


 


uuggggcucugaucgggaagcaggaggggcgaaauaucgaagugaugaacuccuuugagcugcugucccacaccguggaag


 


agaagauuaucauugacaaagaauauuauuacaccaaggaggagcaguuuaaacagguuuucaaggagcuggaguuucugg


 


guugguauaccacaggggggccaccugaccccucagacauccacguccauaagcaggugugugagauaauugagaguccgcu


 


cuuucugaaguugaacccuaugaccaagcacacagaucuuccugucagcguuuuugagucugucaucgauauaaucaaugga


 


gaggccacaaugcuguuugcugagcucacuuacacucuggccacugaggaagcugaacggaucgguguagaccacguggccc


 


ggaugacagcaacaggcaguggggagaacuccacuguggcugaacaccugauagcucagcauagugccaucaagaugcugca


 


cagccgugugaagcucauuuuagaauaugucaaggccucugaagcaggagagguucccuucaaccaugagauccugcgggag


 


gccuaugcccuaugucacugucucccaguucucagcacugacaaguucaagacagacuuuuaugaucaaugcaaugacgugg


 


ggcucauggccuaccucggcaccaucaccaaaacgugcaacacaaugaaccaguuugugaacaaguucaacguccucuacgac


 


cgacaaggcauuggccggcgaaugcggggacuguuuuucugaugaugguucuggaagggaugguguguggggcucagaca


 


gcuguuccauggaccugaguaccacauucccuuuagagaaacucauuaauaaaagagcagccccuuaaaaaaaaaaaaaaaaa


 


aaaaaaaaaaaaaaaa


 









183
D49733
Sequence below.







aaaacccaauguuugguuuuaaagccaaaaauauaagggaagugcauagguuuggguuuuguuuuuuguuuuuucccgag


 


guccuugaucuuugcccccaaauuugagggcauaaaguaaucccucaguuaccuaaaaacacagccauuccuuugccauucc


 


acucuccuggauuggccgcuucugugcgcgggggagaggugacucacuauuacuacugaggaaaggggagccaguggugga


 


aguggggugagucacugaugggcagcagcuucagcccuccccccaacuuccuuggcucucuggggaugccugauccucuccc


 


ucacuuugcaccuacuuccccuggucccucaccacuacccuuugcccacccacucaaauucuuuggcucugcucuuuacucc


 


agaaggccaaaggcaagcuuagaguugaguaggcaggaaccaacauugugaagccccaggccagaaagggguguucugcaga


 


gugaggguuggcaugcuggcuccuccucaccauaccugcccccgccccuuuggguacaggauggcuccuuuaagagcagug


 


gauccacccccuguagaggagggccuauuagagccucugccuggcugucagugacucaguguucgcgggaacgcugccuca


 


gccucaacaccagccaacccagaucccgaggugcgccagcgcccagcccagaucuccacgccugccaggagcgagcuucgccg


 


gcucgcugucccccugagcagccucuguccuucuguccaagucccgcgcccuucucgggaccccugcccagcgggcagcacu


 


gucacccugccggccauggagaccccgucacagcggcgcgccacccgcaguggggcgcaggccagcucuaccccacugucgcc


 


cacucggaucacccggcugcaggagaaggaggaccugcaggagcucaaugaccgccuggccguguacaucgaucgcgugcgu


 


ucccuggagaccgagaacgcggggcugcgccuucgcaucacugagucugaagagguggucagccgagagguguccggcauca


 


aggcggccuacgaggccgagcugggggaugcccgcaagacccuugauucuguggccaaggagcgcgcccgccuccagguaga


 


gcugagcaaagugcgugaggaguucaaggagcugaaggcucggugagugaggcccggccggccggcaccagggaggcagca


 


gucgccuguaacuggccaucuaguccccucccuccccggaacugccucccgcgggugacuggcagugccaannnnnnnnnn


 


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


 


nnnnnnnnnnnnnngcuaggccagauauagaaagcuuucuguauuuaauacacaguacaugcaucauucaugucuacauaa


 


uuaagauaaaggaagcugcauuguuaaugggaaaaaaaauagggucugggaauguagugugccuagcauuuacgaacuucg


 


ggguuuggguuugaucccagcaucucacaaaccacguguaaucccagcacuuggaagguagaggccggaggauccgaaguu


 


uaaggucauucuugacuacuuagcaaauucggggcacccuaggauaccugagacccugucaugaauaaaaauaaauaauaaa


 


uaaaccaauaugggucuagguugagcagcagcuugggcaggguagggccggaaguuagccagguagaggguugcaguccca


 


ggaggacccuggcugggagcagcaccucaguccccugcccaaccacagggggccaccgggucuuuccggaacuccugagggc


 


gcaaggccuugcucucucuggcccagccauggggaacgcggagggccggugaggcaggcggcaggcgggcgggcggggcgc


 


gggccgucauccccuccugcuccuuauuuuuagcccaguguagagucugggccgccugucccucccccaggacagggggag


 


gaaauunnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


 


nnnnnnnnnnnnnnnnnnnnnnnnnnnnngaugccaacaauccuaauguaaugaugcccucuucugacagcugcggggac


 


cgcagagaggucccaucccagaugcacuccugaaaccugcuuuucuuuuucuagcaacaccaagaaggagggggacuuguug


 


gcugcgcaggcccggcucaaggaccucgaggcucuucucaacuccaaggaagcugcccugagcacugcucucagugagaagc


 


gcacauuggagggcgagcuccaugaccugcgggggcagguagccaagguaggccgcuguccugugaccccagugaccccacc


 


ugguccgacauaucauucggucccauuugccugcucaccuucacuucuccagucuagannnnnnnnnnnnnnnnnnnnnn


 


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


 


nnucuagauggggacagccaucaccucuccuuuggcauuuccugaacccccucccaccucuccaugaacuuggcuuucuccc


 


ucucagcuugaggcggcccugggagaggcuaagaagcagcuucaggaugagaugcugaggcgaguggaugcugagaacagg


 


cuacagacgcugaaggaggagcuugacuuccagaagaacauuuacagcgagguaagcgucccgcuguacaggucuuucuuac


 


uguggacagcugggaggggucaccuaauaaugccaggcuaagcgagggcugcccgugccuggccgguggaguuacgacuuc


 


uggucucagcuucuaaggaaccauugcgauguucuaaucuaagugucuccccuuaaccuuucaggaacugcgugagaccaag


 


cgccggcaugagacgcggcuuguggagaucgauaacgggaagcagcgagaguuugagagccggcuggcagaugcccugcag


 


gagcugcgggcucagcaugaggaccagguggaacaguauaagaaggagcuagaaaagacauacuccgccaaggugcuggccu


 


cauccuguccucucccuggugcugcccuggggacgggugggugguggcagggggccagggaugccuuccucaggcccccag


 


cuccagguuccugcucucauaacugugugcucccugcagcuggauaaugccaggcagucugcugagaggaacagcaaccucg


 


ugggggcugcccaugaggaacugcagcagucucgaauccgcauugacagccucucggcccagcucagccagcuccaaaagca


 


ggugacccucaguuuaccccucccaccuuggcucuggucuaagcagauacugcagaagcccacugagaagggggugggggag


 


ggacuccaggaccacaugcuaugguucugaaucugaugccugucuggcuuuccagggcucuccuuuagcuagcccugaucc


 


ucagagccucuauuuuacugugcaugaaggguuuuucauguuucuucugugccugccggagacugaaccagaggccucuug


 


cuugguagauaggugcuuucucacugaguuacaaacccagccgcauucccuacuuggagauagagcuucccuuggacugga


 


cauguagcucaguugguacagugcuugcuuauuauacacgauggccuggcuucuauccccaggaccnnnnnnnnnnnnnn


 


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


 


nnnnnnnnnnucuagagagagccuacagauccugagugucccucugccugccccugugccccucccucuucaucgacauca


 


gcccuugggagcucaucagacccuuugucuuccccgccccaguuggcagccaaggaggcaaagcugcgugaccuggaggacu


 


cgcuggcccgugagcgcgauaccagccggcgccugcuggcugagaaagagcgagagauggcggagaugcgggcgaggaugca


 


gcagcagcuggacgaguaccaggagcugcuggacaucaagcuggcccuggacauggagauccaugccuaucgaaagcugcug


 


gagggcgaggaggagaggugaacuaggaggggucuacagaacuugucaggggccucuggccgcaacuaccaugacuaacccc


 


gcaccgugucuccaccuuccccaggcugcgccugucccccagcccuaccucgcagcgcagccguggccgcgccuccucccacu


 


caucccagucucaggguggaggcagcgucaccaaaaagcgcaagcuggagucuuccgagagccggagcagcuucucgcagca


 


ugcucgcacuagcgggcguguggcgguagaggaagucgaugaagagggaaaguucgugcggcugcgcaacaaguccaacga


 


ggugggccugugaaccaggguggucuuuucaguggcugggaguucuugguucucguggagcaucugucucccuaucugag


 


aauuuggagugugugguaguccugucaucuuuaaauuguugggaagaugcaugauauagggaugggugacccuugagcca


 


auagucuagguuugaugccagagguagugguggaagccugucuuucuuuucuuuuucuuuuucuuuuucuuuuucuuuu


 


ucucuuucuucucucuuuuuuuuuuuuccgauggggucuugcccagguuggcuuugaucucccuaguuaagcuguucccc


 


ugccucagccuccauaguagcuggaacugcaggngcacacuggcgnccagccuaccuaagcuccugagugagauaauccaag


 


agucgguugaacucccuguccuccuuccuccuuccuccuuccuccacccuacuucaggaccaguccaugggcaacuggcaga


 


ucaggcgucagaauggugacgauccuuugaugaccuaucgcuucccaccgaaguucacccuaaaggcugggcagguggugac


 


ggugaguggaagggcacuugggacucuggcuggaguggagaaguuggccucaggacaggagcauuaaaaauaagcacaucu


 


cuuaaaccaucuuuucccagaucugggcuucaggagcuggggccacccauagccccccuacugacuugguguggaaggcgca


 


gaacaccuggggcugugggagcagccuucgcaccgcucucaucaacuccacuggagaagugaguauguugcagccgguagcu


 


ugcuggacaaggcucccccgggugaccauaaugggaacuagcuaccuccaacccaagggaaccugccuuggguuuaggaucg


 


cuuuccugagcccaagucccacccaguaagcaagccagaagucuccccaguagaauaauggguggaagucagccagugagug


 


uuaauagcagacuccagcuuacagagcaccgagcucucaguuguguccuuuuugcgcgugcgugcgcgcgugugcacaugu


 


gcauguguuuauccuuaguccccagcaucagagguuggacaagguuguauaaaggcccgggacaguucuaagugguuacua


 


uggguagacaggcugcacagcccucacccccugacucuugggccugggcuuauguccccacaggaaguggccaugcgcaagc


 


uggugcgcucacugaccaugguugaggacaaugaggaugacgacgaggauggagaagagcuccuccaucaccaccgugugag


 


uggcagccgccgcugaggcccagcccacaaggguagcccugccagccuagggcagcucucccaccuccaugccaaagucuuu


 


ucauuaaagaauguuuuggaaugccacuugcugcccuggccuuucuucucucuccucccucuaccuugaacagggaacccag


 


gugucugguaaggaagggaguggggacuugcugaugccauggauacuccacgguggcaguggacaggguucuggauuugu


 


guccugggaaggggcugggaggacagagguggccccagcccugccucucuuccucacucccauugcaugcacacuucucucc


 


ucucuccuuccacccuauugcaugcuucuccucagauuucccugcaacaauguucucuuuccuuccuguccccucacaaauu


 


aagucucuccaucuuugcucuuccucuugauugccccauaagugucuaagauucaggagagaguuaaagccacagcucuuu


 


auuucgaaggcuuccuggcuauuucccccaucaugcccuuccucccagccacaggucucccaaguccccaucacuugguugu


 


cuggguacagacagaggucaccuuccugcccaauggccaggaagcuccaagagcccacagccuaggugccgguccuaagaag


 


ucagucccaaacucgcugucccuccugagccuugucucccuucccaggguucccacugcagcggcucgggggaccccgcuga


 


guacaaccugcgcucacgcaccgugcugugcgggacgugugggcagccugcugacaaggcugccgguggagcgggagccca


 


ggugggcggauccaucuccucuggcucuucugccuccagugucacagucacucgaagcuuccgcaguguggggggcagugg


 


ggguggcagcuucggggacaaccuagucacccgcuccuaccuccugggcaacuccaguccccggagccaggugagucaucuc


 


ugcccuacagcaggacacugcucacugagcagcagggcagggcagcccaagggaguggggucccccuccuugcagucccucu


 


ugcauccugccccuccugucugaaccccagacucgaggucagggcaaggcccagagugugaggguuggggagacaaccccuu


 


uggggucagggagggagaggaagggccagccacugcugcucacaccucugccuucucuucucucuuagagcucccagaacug


 


cagcaucauguaaucugggaccugccaggcagggcugggggcagaggccaccugcuccccccucaccacaugccaccuccug


 


ucugcuccuuaggagagcaggccugaagccaaagaaaaauuuauccccugccuuugguuuuuuuuuuucuucuauuuuuuu


 


uucuuuuucuaagagaaguuauuuucuacagugguuuuauacugaaggaaaaacucaagcaaaaaaaaaaaucuuuaucuca


 


auccuaaguccuuccccuuucuuuccuuguaucugccuuaaaaccaaagggcuucucuaggagcccagggaaaggacugcuu


 


uuuauagagucuagauuuuuguccugcugccuuggcuuuacccucaucccaggacccugugacaauggugccugagaggca


 


ggcauggaguucucuucaccagccuccuccaacagcuggcccacugccacgccagcugcagagaaauggggcgcagagagga


 


ugacugagaaggucaagccccuccccggcacuacacgaggccgaggcuccucugccugccuuaccuucuuccugcccuuccc


 


uagccuggggcgaguggauucccagaggcaaaucugccgugcuugcuuuuucuauauuuuauuuagacaagagaugggaau


 


gacggggaaggagaagggaagaucaguuugagccuaccuuuucccagcuucugagccuggugggcucugucucaaugaugg


 


agggcaaugucaagugggauacagggaagagugggggacgaaggcucccagagauggggagaaccugcuggggcuggugag


 


aagucuagaggugcggcgauugguggcuacagcaaacacuaaggaacccuucaccccauuucccaucugcaccucugcucuc


 


cccuccaaaucaauacacuaguuguuuccaucccagaugcuguggugucucuuuguugggugugauguguguuuucaggg


 


gcagacacaugcacacagaggugccacacauucacuauauauucacuacccagcuauaaagguguguaugagggagacuucu


 


agaaaggucagcauauguggggugagcgagggguguccuuccuaucccucauccauccagcaccuuuuaaaaggggccagca


 


auccacaugugcaucagacacaggagcacagagagacggaggguagaguagggcagaguagcagagcuuccuugcugcccug


 


uagucgcaggcucuugaucgugugaucgcu


 









184
X80899
Sequence below.







gcggugcgaagcgggccuccgccaacauguacuacaaguuuagcaguuucacgcagaaguuggcuggagcuugggcuucgg


 


aagccuacaccccgcagggguuaaagccaguuuccacagaagcaccaccuaucauauuugccacaccaaccaaacugaccucc


 


agugugacagcauaugauuauucugggaagaacaaaguuccagagcugcagaaguuuuuccagaaggcugaugguuuccac


 


cugaaacgaggccuuccagaccaaaugcuuuaccggaccaccauggcucugacacugggagggaccaucuacugccugaucg


 


cccucuacauggccucgcagcccagaaacaaaugagcuugccuguggaggacugguucacuuuguggcacaaacccuuugaa


 


uccucacguuucauguuuuccacuuggauagucuacuuaacauuuugcaaacaaaggaaaagauaagaauacauuguuuug


 


auuuguuuauggugugcagauggccugucagaugucagagcugguuugacaguuaaaacuauuguuuaaggaaaugucac


 


ugagccaucacugagcugugcuucugcuccugauuucccuggaguucugcaggaaaguugcucuccagcucauucguggcc


 


agccgugcucagggccucgggacucaggcggugucugagcgggaagcgaacgcggaagccuuuuggaguguaggugugauu


 


gaggaaggaaaacaaaagccagcggacagguggugaagugagggcugaguuagccacccuagggauucguccgccuugcaga


 


aaacauugagaggaaugauagcaaccugccucuauuugugggcaguugguuucaaaggguugugugucucgcccagaaccu


 


agggaaauggguguuuguuccaucgugggaggagcaccugucagugcugcacauuagacagcugugucaggacuucuccuu


 


uaauaaugcuguggcuuuacguuaugauugaccggacugcggaauaaacacuggaaucaaaaaaaaaaaaaaaaaaaa


 









185
D83203
Sequence below.







cugagacagaacgaaacguccgcagauaacuacccguucuggcucuuguuaguucuauguguauggauaaugucuugggag


 


guuuugaaaugccacaagccuugcuggcccagggugcagcugccucugccguucagaccucagauuauaaggacagaacaca


 


gcacggaaguggggggaucagaaccaugggagauccaggacgaaggguccugugcgcaggugcggcaccgaauccuauauu


 


ugacauugaagcugucgucagcccaacuaguguguuauuaacauggaagcacaaugacucaggcgcuucagaauguagaaua


 


gagaauaagauggagagcaaucugacguuuccuguuaaaaaccagacaucauguaacauuacaggcuuaagcccagguacuu


 


cguauacauucuccaucaucucuguaacaaccaaugagaccuugaacaaaacuaucacaacagagcccuggccagugucugau


 


cuccaugucaccucugugggugugacacaggcucgucucaccuggagcaaugcaaauggcacugccuccuaccggaugcuga


 


uugaagaguugaccacacauuccucagucaauauuucaggucugaagccggggaccaauaauacguucgcuuucccagaauc


 


aaaugagacacaggcugacuuugcaguugcagaggaggucccggaugccaaugguaccaagagaaucccagugaccaaccua


 


ucccaaccacacaagaauucucuugccucuguggacccacccucuggccaggaucccucccucacagagaucuugcuuacuga


 


ccuaaagccugauacucaguacaaugccaccaucuauucucaagcagcaaauggcacugaaggacagcccaggaacaaagugu


 


uuaaaacaaauuccacccagguuucugacguccgagcuaugaacaucagugccucaagcaugacccugaccuggaaaagcaau


 


uacgaugggucccguacuucaauugucuacaaaauacacguggcugggggggaccacuccgucaaccaaacugucaauaaga


 


cugaggccaucauccucggacucagcuccagcaccuuguacaacaucacaguucauccuuuccugggucagacggagggcac


 


accaggcuuccuccaaguguacacuucccccgaucaggucucugacuuccgagugacaaaugucagcacaagggcaauuggu


 


uuggcuuggaggagcaaugacuccaaguccuucgagauuuucaucaagcaggacggaggugagaagcaucgaaaugcuucg


 


acgggaaaccagagcuauaugguugaagauuuaaagccuggaaccaguuaccauuuugagauaauuccacgaggaccagacg


 


ggacagaagggcuguccaguacagugaaugggagcacugaccccagugccgugacugacauccggguggucaacauuagcac


 


cacugaaaugcaguuggaguggcagaauacggacgaugccucuggauacacuuaccauuuaguucuagagucuaaaaguggc


 


uccaucaucaggaccaacaguucucagaaguggaucacaguagggagccucaccccaggcaccuuauacaaugucacaaucuu


 


uccagaaguggaccagauccagggaaucuccaacuccauuacccaguacacacggcccagcagugugucccacauugaaguaa


 


acaccaccaccaccacggcagccauccgauggaagaacgaggacacagccucugcuuccuaugccuacuccguccuuaucuug


 


aagacuggagauggcagcaauguaaccagcaacuucacaaaagacccuucuauucuaaucccugaguuaaucccuggcgucu


 


cuuacacagugaagauccuuacacaaguuggggaugguacaacaucacugguaccugguuggaagcuguucuguacggaacc


 


ugaaucagugaccuccuuccacugugaaguggucccuaaggagccagcauugguucucaagugggccugccccuuuggcau


 


guacacaggcuucgagcugggggucaggagugauuccugggacaauaugacacgccuagagaacugcacaucggaugaugac


 


acagagugcaggacggaagucgccuauuugaauuuuucuaccucguacaacaucagcaucgccaccuugucaugugggaaga


 


uggcgcuucccgcccagaacaucugcaccacuggcaucacagacccaccuacuccggauggauccccuaauauuacaucgguc


 


agucacaauucaguaaagguuaaguucagcggguuugaagccagccacggaccuaucaaagccuaugcugucauccucacca


 


ccggggaagcugcccaaccuucugcagauguuuugaaguacacguaugaggauuucaaaaggggagccucggauacuuaug


 


ucacauaccucauaagaauagaagagaagggacagucucagggcuugucugaagucuugaacuaugaaauugauguggggaa


 


ccaauccacuacccucggcuacuacaacgggaggcuggagccucugggcuccuaccgggauuguguugcuggcuuuaccaau


 


auuaccuacaaccuucagaaugacggccucaucaauggggaugagagcuaugugucuuucaguccauauucagaggccgug


 


uucuugccccaggauccaggugucaucugcggagcaguguuuggauguaucuuuggugcccuggccaucacagcuguggga


 


ggcuucaucuucuggagaaagaaaaggacagaugccaagaauaaugaaguguccuuuucucaaauuaaaccuaaaaaaucca


 


aguuaauccgaguggagaauuuugaggccuacuuuaagaaacagcaagcugacucuaacuguggguuugcagaggaauaug


 


aggaccugaagcugauugggauaaguuuaccuaaauacacagcugagauagccgagaacagagggaagaaccgcuacaacaa


 


uguucugcccuaugauauuucucgagucaaacuuucaguccagacccauucgacagaugacuacaucaaugccaacuauaug


 


ccuggcuaccauuccaagaaagauuucauugccacacaaggaccuuuacccaacacuuugaaagauuucuggcguaugguuu


 


gggagaaaaacguauaugccauuguuauguugaccaaaugcguggagcagggaaggaccaaaugugaggaguacuggccuu


 


ccaagcaggcucaggacuacggggacauaacuguggcgaugacaucagaagucguucuuccagaauggaccaucagagauuu


 


uguggugaaaaauaugcagaauagcgagagccauccucugcggcaguuccauuucaccuccuggccugaccacgguguuccu


 


gacaccacugaccugcucaucaacuuucgguaccugguccgggauuacaugaagcagauaccccccgagucaccaauucugg


 


ugcauugcagugcugggguuggaaggacgggcacuuucaucgccaucgaucgccugaucuaucagauagagaaugagaaca


 


ccguggacguguaugggauugucuaugaccuucggaugcacaggccucugauggugcagacagaggaccaguauguuuucc


 


ucaaucaguguguuuuggauauuaucagagcccagaaagacucaaaaguugaucucaucuaucagaacacaacggcaaugac


 


aaucuaugaaaaccucgagccaaguuccuugaaugugacuauguugcuucauccacagcugaacgauuuuggauguugggu


 


ucuagguccuggcuguugcuggucugcuaggauccagggccuuguugacaucugggaagauguaaauugucccgcugaagg


 


ccgcaguuuuagauguggccacuagauggagccagagcacugguaugaaggagcaccagggccguguaaggcaaaagaggac


 


ccagaaaaagaaacuuaacuuguucacuccugagaaaccugcaagucaacaagccaaggaagugccuuugcaugcauuuggu


 


agccuuuccaaucccgcuuauuacauaauauguucauguucauggcaaaaaaaaaaaaaauaaaauaaaauaaauaaaaaagg


 


aaaacaaaauaaaaaaaaucuuagaacauu


 









186
Z20410
gcccccucaagggcauccugggcuacacugagcaccagguggucuccucugacuucaaca




gcgacacccacuccuccaccugacgcuggggcuggcauugcccucaacgaccacuuuguc




aagcucauuuccugguaugacaacgaauuugcuacagcaacaggguguggaccucaugg




cccacauggccuccaagguaagccccuggaccaccagccccagcaaggcacaagaggaagg




agagacccu


 


187
AI839906
uuuuuuuuuuuuuuuuucauauuaaacuuguaguuuuauucagguuugauuuuuaaca




aaugugucagggagagagcccacaggaaaggguaaagcccgugggggcaaggccuuccca




gaugccugaggagggaucguguccccucccccccuccucuucucaccaccccuacagggg




uuugggaagagacacaggcagggaaggggcugguccccagucuguacaguggugcuugg




gggugaaggacuauggagaacaggggaccagaucggggaugaguaggauaaagggcaca




agaccauuuaccagaauccagcuuucugauuccaaauugaauuaaaaagaaaaaaaggag




aggggaaccuaaaccacaagcaguacccaacucccuuucccccaucagggcugc


 


188
AI843448
uuuuuuuuuuuuuuuuuagggaagaggcugaugccagauaaguuuuuauuauauuaaa




aaaaaaaaaaaaaccagugcaacuggaaaucagggugagucgcuggaggugagugagagu




cggaaggcccuccacaccucagugguggcaggaucuggacccguagccuaagccuggucu




gauccagccgagaugcuggaaagcagagcacacgguggugcccaucagggcaaagagggc




aagagagcccacggcuccuccauaccgcuugcuagggucuccuguguaguagccauaugc




guaaaggacucgcccaauaauccaggccaggcccaggccagaagcuaugcgcggguggua




aacaccucccaccguuaggaaaaa


 


189
AW125336
cggccgcgugaguuuugacugagcuucugcangaaguucanaugcaacuccauacauca




guucauuuucuagcauuaccacuggguuauuaucacgaauggccgauuuaauaaguccu




uuugcauccucggaauuccaggggcugaccacuuuuaaaccugggcagugcccauacca




ugcagcaaagcauugcgagugcugagcagcuacaccugcugaggcgccauugggcccccu




gaauacuaugggcaca


 


190
AW123802
uuuuuuuuuuuuuuuuugaagggccauuggaguuuauuuacagacaaccuuaggugag




gccuuuuccucuaggaucuacaugcuuuugaaguuacuugguuucaggcuucuugucu




ccagcuucgagcuugagacucucaggaggcuggcgauaggcagggaaagccucccaggg




gcuguucaggucaaacuugcggaauucuugugccagcuccacugguucagccacuaccc




gcuuuaccucaucgucguaacgaagcucaacauagccagugaggggaaagucuuuccgga




aaggaugucccucgaagccauaaucugucaggauccuucuuaaaucagggugguuaaaa




aaaaaaaaaaaaaaaaaa


 


191
AI835771
uuuuuuuuuuuuuuuuuggggggcagcgaacuuuauugaugguauucaaaaaaauagg




gagggcucccuaggcccccccuguuauuaugggggucugggauggaaauuuugagggaa




augcucaauuuugggggcccauuugggaaaaggccccccuugcccaauguccuugcugg




ggugggugguccaagguuucuuacuccuuggaggccauuuuggccaagagguccaccac




ccuguugcuguagccguauucauugucaaaccaagaaaugagcuugacaaauuugucau




ugaaaaaaaugccaaccccggaaucaaagg


 


192
X53584
Sequence below.







gcuccucaucucacucgggccuaugccaaagauguaaaauuuggugcggaugcucgagccuuaaugcuucaagguguagac


 


cuuuuagccgaugcuguagcuguuacaauggggccaaagggaagaacagugauuauugaacagaguuggggaagucccaaa


 


guaacaaaagauggggucacuguugcaaagucaauugauuuaaaggauaaauacaaaaauaucggagcuaagcuuguucagg


 


auguugccaauaacacaaaugaagaggcuggggauggcaccaccacugccacuguucuggcacggucuauugccaaggaggg


 


cuuugagaagaucagcaaaggggcuaauccaguggaaauccggagaggugugauguuggcuguggaugcuguaauugcuga


 


acuuaagaaacagucuaaaccugugacaaccccugaagaaauugcucagguugcuacaauuucugcaaacggagacaaagaca


 


uugggaacaucauuucugaugcaaugaagaagguuggaagaaagggugucaucacagugaaggauggaaaaacccugaauga


 


ugagcuagaaauuauugaaggcaugaaguuugauagaggauauauuuccccauauuuuauuaacacaucaaaaggucaaaaa


 


ugugaauuccaagaugccuauguuuuguugagugaaaagaaauuuuccaguguucaguccauugucccugcucuugaaauu


 


gcuaaugcucaucggaagccauuggucauaaucgccgaagauguugacggagaagcucuaagcacgcugguuuugaacaggc


 


uaaaaguuggucuucagguuguagcagucaaagcuccaggguuuggggacaacaggaagaaccagcuuaaagauauggcua


 


ucgcuacugguggugcgguguuuggagaagaggguuugaaucuaaaucuugaagauguucaagcucaugauuuagggaaa


 


guuggagaggucaucgucaccaaagaugaugccaugcuuuugaaaggaaaaggugacaaagcucacauugaaaaacguauuc


 


aagaaaucacugagcagcuagacaucacaacuagugaauaugaaaaagaaaagcugaacgagcgacuugcuaaacuuucagau


 


ggaguagcuguguugaagguuggaggaacaagugauguugaagugaaugagaagaaagacagaguuacugaugcucucaau


 


gcuacaagagcagcuguugaagaaggcauuguucuaggagggggcugcgcucugcuucggugcaucccagccuuggauuca


 


uuaaagccugcuaaugaagaccagaaaauagguauagaaauuauuaaaagagcacuuaaaauuccugcaaugacgauugcua


 


agaaugcagguguugaaggaucuuugauaguugagaaaauucugcagaguuccucagaaguugguuaugacgccaugcuug


 


gagauuuugugaacaugguggaaaaagggaucauugauccaacaaagguugugagaacugccuuacuggaugcugcugggg


 


uggccuccuugcuaacuacagccgaagcuguagugacagaaauuccuaaagaagagaaggacccuggaaugggugcaauggg


 


uggcaugggaggggguaugggaggcggcauguucuaacuccuagaguagugcuuugcccuuaucaaugaacugugacagga


 


agcucaaggcagguuccucaccaauaacuucagagaagucaccuggagaaaaugacugaagagaaggcuggcugaccacugu


 


aaucaucaguuacugguuuccuuugacgauauauaaugguuuacugcugucauuguccaugccuacagauaauuuauuuug


 


uauuuuugaauaaagaacauuuguacauuccugaugcugguugcaagagccauauaccaguguccugcuuucaacuuaaau


 


cacugaggcaucucuacucuucugugagucaucaggacuguagcgcugugucaacaaaacauagagaguucagaagacagcc


 


uuucuguggaagggugggaaugauuguguacaaaguagagaaguauccaauuaugugacaaccuuuguguaa


 








193
M32599







acagccgcaucuucuugugcagugccagccucgucccguagacaaaauggugaaggucggugugaacggauuuggccguau


 


ugggcgccuggucaccagggcugccauuugcaguggcaaaguggagauuguugccaucaacgaccccuucauugaccucaac


 


uacauggucuacauguuccaguaugacuccacucacggcaaauucaacggcacagucaaggccgagaaugggaagcuuguca


 


ucaacgggaagcccaucaccaucuuccaggagcgagaccccacuaacaucaaauggggugaggccggugcugaguaugucgu


 


ggagucuacuggugucuucaccaccauggagaaggccggggcccacuugaaggguggagccaaacgggucaucaucuccgcc


 


ccuucugccgaugcccccauguuugugaugggugugaaccacgagaaauaugacaacucacucaagauugucagcaaugcau


 


ccugcaccaccaacugcuuagccccccuggccaaggucauccaugacaacuuuggcauuguggaagggcucaugaccacagu


 


ccaugccaucacugccacccagaagacuguggauggccccucuggaaagcuguggcgugauggccguggggcugcccagaac


 


aucaucccugcauccacuggugcugccaaggcugugggcaaggucaucccagagcugaacgggaagcucacuggcauggccu


 


uccguguuccuacccccaauguguccgucguggaucugacgugccgccuggagaaaccugccaaguaugaugacaucaagaa


 


gguggugaagcaggcaucugagggcccacugaagggcaucuugggcuacacugaggaccagguugucuccugcgacuucaa


 


cagcaacucccacucuuccaccuucgaugccggggcuggcauugcucucaaugacaacuuugucaagcucauuuccugguau


 


gacaaugaauacggcuacagcaacagggugguggaccucauggccuacauggccuccaaggaguaagaaacccuggaccaccc


 


accccagcaaggacacugagcaagagaggcccuaucccaacucggcccccaacacugagcaucucccucacaauuuccauccca


 


gacccccauaauaacaggaggggccuagggagcccucccuacucucuugaauaccaucaauaaaguucgcugcacccac


 









194
AF035644
agaagcuuccuaaggaacaagcaaguugaauagagaaaauagugaucaauaauaggcauu




uuaguggucuuuuuaauguuuucugcugcggaacauuucaagauuuauugauuuccucc




uccccccauuuuuuucccaccacacucacacacgcacgcucacacuuuuuauuugccauaa




ugaaccguccagccccuguggagaucucuuaugagaacaugcguuuucugauaacucaca




accccaccaaugcgacucucaacaaguucacagaggaacuuaagaaguacggagugacaa




cuuugguucgaguuugugaugcuacauaugauaaagcuccaguugaaaaagaaggaaucc




acguucuagauuggccguuugaugauggagcuccacccccuaaucagauaguagaugauu




ggcuaaaccuguuaaaaaccaaauuucgugaagagccaggcuguuguguugcagugcauu




guguugcaggauugggaagggcuccugugcuaguugcgcuugcauugauugaaugcggaa




ugaaguaugaagaugcuguucaauuuauaagacaaaaaagaagaggagcauucaauucca




aacagcugcuuuacuuggagaaguaccgaccuaagaugcgguuacgcuucagagauacca




augggcacugcuguguucaguagaaguagaagcaggcuggcuggaucguggcauuagagg




gaa


 


195
Y00629
Sequence below.







auucagguuccucacagacccagggggugaggauguugcuuuuugcccacuugcuucagcugcuggucagcgccacagucc


 


cgacccagaguaguaagugaggggaggggugaggggagggguugggagcgaaaaagacucugugaggaaaagcgggagggu


 


ggugguggcggaggugcagcaccccaaguuccgccgcccuguccuagucccucccccgccuuuaccugggaccuugagccug


 


ggggaggucggggucucaccgcgcgccgcccccaggcccacacucgcugcgguauuucaccaccgccgugucccggcccggc


 


cucggggagccccgguucaucauugucggcuacguggacgacacgcaguucgugcgcuucgacagcgacgcggaaaauccga


 


ggauggagccucgggcgcgguggauugagcaggaggggccggaguauugggagcgggagacuuggaaagccagggacaugg


 


ggaggaacuucagaguaaaccugaggacccugcucggcuacuacaaucagaguaacgacggugagugcggcugggaucacag


 


cuaugaucacuccauguccccugagacgggccugggucaucuugacccgcugagacaaaguuucauccaaacgccuacccag


 


aaccucagacaaaaaagcccccgcagaguucugcuuagguuugggguuguacuuuuguuucucuuuuguuuugagauaucu


 


acuaacauugggcaaaguggccacagguggcgcucaucagcguaucccuuccagaaucucacacgcugcaguggauguacgg


 


cugcgacguggggcccgaugggcgccugcuccgcggguauugucaggaggccuacgauggccaggauuacaucucccugaa


 


cgaggaccugcguuccuggaccgcgaaugacauagccucacagaucucuaagcacaagucagaggcagucgaugaggcccac


 


caacagagggcauaccugcaagguccuugcguggaguggcuccauagauaccuacggcugggaaaugagacacugcagcgcu


 


caggugcccuggagagcucuccucacuuuuccucugcgguuugggggaaauccuugagguauaaccucaggggcagaacgc


 


uguucagcgggcacagcgcggaggaggagggagagggacucccaaaacugcuuuuccccuguagggauucuaauccuuaaca


 


aaagcagaucaggcucgacaauggcccuggacccauggggggagggggcucuuucucaggccucccuccuugcccuacucag


 


ugucucuauagucagacuccagcuuuucucaaucucuuggcccucauccagcucaggaccagaagcccuucccaugagucug


 


cagagaccuggagccuccuguccauguuguccugcucacauccuaaggcaucccuaagagcagauccucccaggugcaggug


 


cucuagcuggugucuagaugauggacaccauaaucccaccgcaguccuccuguccaccccaggacggucacaugaacacugc


 


ugaguccccagaagaaagcaagaugccucauccuuucaacucucucccucagacccuccaaaggcacaugugacccaucaccc


 


uagaucugaagaugaagucacccugaggugcugggcccugggcuucuacccugcugacaucacccugaccuggcaguugaau


 


ggggaggagcugacccaggacauggagcuuguggagaccaggccugcaggggauggaaccuuccagaagugggcagcuguc


 


guggugccucuugggaaggagcaguauuacacaugccauguguaccaugaggggcugccugagccccucacccugagaugg


 


gguaaggagggugugggugcugaacuggggucagggaaagcuggagccuucugcagacccugaguuggucauggcucagag


 


cugggaucauaacccucaccuucauuuccuguaccuguccuucccagagccuccuccauccacugucuccaacaugguaauc


 


auagcuguucugguuguccuuggagcugugaucauccuuggagcugugguggcuuuugugaugaagaggaggagacacau


 


agguaggaaagggcagggucugaguuuucucucagccuccuuuugcagugugcucugcuccuuaaugggaaacauagccac


 


acccacauugcugcagucuccaacugggucagcugucaguuccgggaacucccuagggcugguguuucucuggucucucau


 


ggcuuuucuucucacagguguaaaaggaugcuaugcucauguucuagguaagugcgagagaggggcaggggacacccuugu


 


cccugaggcucucaggauggagcugggauuuguuccagcccauaaucuccucuugccacauccucucugucuccucugugu


 


gccuuguuaucucuucuacugcaggcagcaagagcuuccagaccucugacuggccucagaaggcaugaaaaucccugggggg


 


gcuggugagauggcucaguggguaagagcacugacugcucuucugaagguccagaguucaaaucccagcaaccacauggug


 


gcucacaaccauccguaacgagaucugacucccucuucuggagugucugaagacagcuacaauguacuuacauauaauaaa


 









196
AW125380
uuuuuuuuuuuguucccuugaaagccagauguuccaaaaaguagccugcuccauuguucu




ucucagucucauagcgacugccagcgucaauccacacucccaccgugcagguagcaugcg




aggacugcuccgaggccacacgcagcccguuguccaagaugcugaccugggucuccggca




cgcucuggagggccugggcgaagguugcgguaccccgcaaggcagguaaccucagcaggg




ccggcgagcggcgggugcgccucgugccg


 


197
U68564
Sequence below.







ggugcuuaauguuuugaccuguagagguccucacuuuucgucauggcgcugaagguggcgauagcugcuggcggugcugc


 


aaaggcaaugcucaagccaacucuccucugccguccuugggagguucuggcugcccauguggccccccgaaggagcauuucc


 


ucacaacaaacaauuccuccaucugcuaaguauggugggcggcauacagugacuaugaucccaggggauggcaucggcccag


 


agcucauguugcauguuaagucuguauucaggcaugcaugugugccgguggacuuugaagaggugcauguaagcuccaacg


 


cugaugaggaggacauccgcaaugccaucauggccauccgccggaaccguguggcccugaagggcaacauugaaacaaauca


 


uaaccugccaccaucccacaaaucucgaaacaacauccuucgcaccagccuagaccucuaugccaacgucauccacuguaaga


 


gccugccaggaguggugacccggcacaaggacauagacauccucauuguacgggaaaacacagaaggcgaguacagcagccu


 


ggagcaugagagcguagcaggagugguggagagcuugaagauuaucaccaaagccaagucccugcgcauugcugaauaugc


 


uuucaagcuggcccaggagagugggcguaagaaagugacggcugugcacaaggccaacaucaugaaacugggugauggacuc


 


uuccuccagugcugcagggaaguagcagcccacuacccucagaucaccuuugacagcaugauuguagacaacacaacaaugca


 


gcugguaucccggccucagcaguuugaugucauggugaugccuaaucucuaugguaacauugucaacaacgucugugcagg


 


gcuaguuggaggcccaggccuuguggcuggggccaacuauggccauguguaugcaguauucgagacagcuacaaggaacac


 


aggcaaaaguauugccaauaagaacauugcuaacccgacugccacacugcuagcaagcugcaugaugcuagaccaccucaagc


 


uccacuccuaugccacuuccauccgcaaagcugucuuagcauccauggacaaugaaaauaugcauaccccagauauuggagg


 


ccagggcaccacaucccaagccauccaggacaucauucgucauauccgcaucauuaauggacgggcuguggaggcuuagcua


 


ucccuacaguuuugcucagcuugucuguaggacucucuucucacuuuagcacuccagcuagcuugggggacaggacccaga


 


auaaagccacuucuguuccagaaaaaa


 









198
AW125346
uuuuuuuuuuuuuuuuuguucuuaauagaaaacuuuauuuucacugauaaugucacugua




acauaauuucauagcagaccugugcaaaagaucccacaucaccaaugucuccaagagauu




ucacacacuucugggcaggacgcacagcucugcccccacccccguguugacagucaacau




uuuacccccgcuaugaguacagaaaggcgaggcaucauaacgaagccgccugaaggcagc




gugagcugaagucggacgcuugccaccucugaaugaauggucaccacagcaacagcacau




gguugccucagugugcucagggugggucuuugaaaaaacgucccacuauguaaauaugcu




gcacuuaucccuucaacauugu


 


199
X61232
See above (same Accession Number).


 


200
D20333
gauccuguauauguguguuuugggggagcuaugauaaguuuuauggcaaacgguugguau




uguuaacuuuuuauugucaucaaaaguucauaaaaguccuauuaauccccauauucunnn




ncugcccuuaacucugguauacaccaaaaagaaaucuuuacuuuccuuguuuuaucauua




uaaaaauaaaguauuuugcuaguauggaaa


 


201
AB025218
aguccgcgucccggcgucggcccgucccgcaccauggugacgcucgccgagcugcuggcg




cugcuggccgcgcugcuggccacggccucgggcuacuuugucagcaucgacgcgcacgcc




gaggagugcuucuucgagcgggucaccuccggcaccaagaugggccucaucuucgaggug




gcggagggcggcuuccuggacaucgacguggagaucacaggaccagauaauaaaggaauc




uauaaaggagaccgggaguccagcgggaaguacacauuugcagcccacauggaugggaca




uacaaguucugcuuuagcaauaggauguccacuaugacuccaaagauaguaauguucacc




auugacauuggggaggcucccaaaggacaagacauggagacagaagcucaucagaacaag




cuagaagaaaugauuaaugagcuggcaguggcaaugacagccguaaagcacgaacaggag




uacauggaaguccgggagagaauacacagagccaucaaugacaacacaaacagcagagug




guccuuugguccuucuucgaagcucuuguucuaguugccaugacauugggacagaucuac




uaccugaagagauuuuuugaaguccggaggguuguuuaaaaggccuuuuccuguugaucc




caaauucaugauuuacu


 


202
U84411
Sequence below.







gcauuggcucugggcugcggccggcucggcgacgcuccucgggcagcucacugcauggucgucuggugcccccgccgccug


 


cauccccgccgccgccccgcgacgcccaccgccgccugcccugccgccgccgccugcgccgccucgggaccggcuguaugauu


 


aggccacaaucuucaaugaguagacauauuccucaguucugugguguucucggucacacauuuauggaguuucugaagggc


 


aguggagauuacugccaggcacagcacgaccucuaugcagacaagugaacuguagaaauucauuacuacuccaccaagaaacc


 


cccauaagaguggauaaccuggacacaggcguguugaauugaaaucugcacagcauuugagaagagcucagaccuggauggg


 


guaaaccucagugccacuuccuuuguauugccucuaguauuacugggauugaagagucacugcuucuuguuuaggagguuc


 


auuucauuggcccguuucucccaauuucauacucaagcacugagaauuucaaguggaguauaucgaauaucgaaguagacu


 


ucagguuguuuuuugguuuuguuuuguuuuuuuuuuguuuugguuuuuuuuuuuuuuuucuguuuugguuuaaaucau


 


uucuguauucaauuuuuuaauucuuucauaacccuauuggguguuuuuuuaaacuaaauuaacauggcucgaaugaaccgc


 


ccugcuccuguggaagucacauacaagaacaugcgauuucuuauuacacacaauccaaccaaugcgaccuuaaacaaauuuau


 


agaggaacuuaagaaguauggaguuaccacaauaguaagaguaugugaagcaacuuacgacacuacucuuguggagaaagaa


 


ggcauucauguucuugacuggccuuuugaugauggugcaccaccauccaaccagauugucgaugacuggcuaagucuugug


 


aagauuaaguuucgugaagaaccugguugcuguauugcuguccauugugucgcaggccuuggcagagcuccggugcuugu


 


ugcccuagcauuaauugaagguggaaugaaauaugaagaugcaguacaauucauaagacaaaagcggcguggagcuuuuaac


 


agcaagcaacuuuuguaucuggagaaguaccguccgaaaaugcggcuccgcuucaaggauuccaauggucauagaaacaacu


 


guuguauucaauaaaacuggggugccugaugccauugccuuggaaguggaacuucagaugggaccugauuugucaugcaua


 


uuacccaaugugucggcuuacugaauaagucuacugcagcuccacaggaauacugaaaaaccagucuuaccaggccacaagu


 


uugacagaauugcaaccucuauauuugggcuaugaucaacauguuuggacacuuagcaaaagauuuuugcuguucagcauu


 


uaaaaugugcuuauuauuuguaccaauugaccuuuccuaaaauaagguauugaguuaugucauuaaauguacuccugugcc


 


agaauauuauuagucuauaaggaauuuagaaggauuaggugccaaaauacccagcacaauacuuguauauuuuuagcaucau


 


acagaaccaaaauugcaggaacugagaacucucagaccauccaugguguauuccuucagucauuucaaacacugcagggcuc


 


cucucguuaucugccugcucacucuguuuacaucucccacacuuaugccagaauacgucagguuugcuuagccauccuuua


 


uuuuuuuuauuuuuuuuuuuaacuaagucuugcgcugauuauuuaauaugucugucucauuuuguuuuguuuugggaaa


 


ccucugucugaaaaaucaacuuuguuacagaagcacauaucuucaacaaugucuccagacaaaaagccuuauaguuaauuua


 


auguuugcacucagaagugcaaccuaacagggagggccugaaaaagaaacgagaggaggcuauuaaauauuuuuaguaauau


 


guugccuuugucaugugcagaacauguagaguaugcucuuaauuuaguaaauauuuuuaagacauagagauacauguguag


 


cuaacccauucuuauucaaaauucuggaauuuuguguuuuccnauaccuaucaggaaguuuccagcuuguuugaauuaugg


 


cuuuccucuucccaaucucuugcaaaaaagacaaagugggaugaaucugcuagugaacugagcagaaauguuuuauaacgcc


 


uuuugagcuauguaacuuaauaauuggauacuugaucauuuguuuuauuauguaaucggauaaaauggugauguguauua


 


aaguuaguucaaccauauauuuauacugucugggaaugugugguuauaguucugugggagaaauaguuugucaguguuca


 


ccagcuuguaaaaacuuaguaugagagcuucaacauuuaaauaaaugaugaaccgcauucgucacugaggacacuuuugccu


 


aaaauuaacuuaauuuguagaaaacaauggauucaguuaauaucauuucaauuuauggaaaaaauuguuaggguugccaag


 


ugcuuuuuauuaaaaguuucucuuuaaaggucuagauaauugugaaucaguugaauguugggcaccgaggggaaacaguuu


 


guaauagaugaucuagauuuuucaguucaguuccaucagucacuuguagcucugcaauuuccagaccaguuuucucauuuu


 


uaaguucauuacaugccuguauauauuuugaaauuaacuugaaccugaguauuuggcacaugauggcuuaauaaauuuuaa


 


cuuuc


 









203
M62362
Sequence below.







acgcuccccaaccuccaccuccccucgcucggccucuauaugcucccgggcucccuaguguuggcuggaagugggugacuua


 


gaggcuuaaaggaggggcgccuaaccacggaccacgugugugcgggggcgacagcgccgccgggguggggcugagcgcugc


 


aagccggguucgccuugcagcgcaggagucagugggcguugcgccacgaucucucuccacuagcacuaugcucccgccccac


 


ucaccgccuuggaaagucacaggagaaggcgggcucuaagacccagcaggcaccauccuacuggcgccuucgauccgagaccc


 


guuuggacaccagggggcgaugccgacccucuauaaaagcgguccccgcgcgggccuggccauucgcgacccgaagcugcgc


 


gggcgcgagccaguuggggcacugggugggcggcggcgacagcggcgccacgcgcaggcuggaggccgccgaggcucgcca


 


ugccgggagaacucuaacucccccauggagucggccgacuucuacgagguggagccgcggcccccgaugagcagucaccucc


 


agagccccccgcacgcgcccagcaacgcccgccuuuggcuuuccccggggcgcgggccccgcgccgcccccagccccaccugc


 


cgccccggagccgcugggcggaucugcgagcacgagacgucuauagacaucagcgccuacaucgacccggccgccuucaacga


 


cgaguuccuggccgaccucuuccagcacagccgacagcaggagaaggccaaggcggcggcgggccccgcggguggcggcggu


 


gacuuugacuacccgggagccccggcgggccccggcggcgcggucauguccgcgggggcgcacgggcccccucccggcuacg


 


gcugugcggcggccggcuaccuggacggcaggcuggagccccuguacgagcgcgucggggcgcccgcgcuacggccgcugg


 


ugaucaaacaagagccccgcgaggaggacgaggcgaagcagcuggcgcuggccggccucuuccccuaccagccaccgccgcca


 


ccgccaccgccgcacccgcacgcgucucccgcgcaccuggccgccccccacuugcaguuccagaucgcgcacugcggccagac


 


caccaugcaccuacagccuggccaccccacaccgccgcccacgcccgugcccagcccgcacgcugcgcccgccuugggugcug


 


cgggccugccuggccccgggagcgcgcucaagggcuuggccggugcgcaccccgaccuccgcacgggaggcggcggcggugg


 


cagcggugccggugcgggcaaagccaagaagucgguggacaagaacagcaacgaguaccggguacggcgggaacgcaacaaca


 


ucgcggugcgcaagagccgagauaaagccaaacaacgcaacguggagacgcaacagaaggugcuggaguugaccagugacaa


 


ugaccgccugcgcaagcggguggaacagcugagccgugaacuggacacgcugcggggcaucuuccgccagcugccugagagc


 


uccuuggucaaggccauggcaacugcgcgugaggcgcgcggcugcgggaccgccuugggccggcccccuggcuggagaccca


 


gaggaugguuucgggucgcuggaucucuaggcugcccgggccgcgcaagccaggacuaggagauuccgguguggccugaaa


 


gccuggccugcuccgcguguccccucccuuccucugagccggacucggugcgucuaagaugagggagucaggccguggugg


 


uuucuccuugagaccgagagacuuuuccgcggagcugagcugggggcccggcaguacuaguauuaaggaaguaaccuugug


 


ccuuggauacucaaaacucgcuccuuuuccuaccgaguagggggagcaaaaaugugccuugauauuuuauuuggaggauuc


 


cugcuuccucucgggccucagcuggcccccgugagaaaaaugaagggugcaggcccagggcaggaggaagauacaggaagcu


 


gagaucccggcagugcccugagcugccccucagucccugucuuuagaggggagggacuuagguguuggggauuugagucug


 


uguccucacccccagcuacagggagguggagggcuccuaaucccuugcuuuuugcaccuccaccuacauccccccccccccac


 


ucagcuuacaacaggccagguuuccugggugaguucauggagaaugggggcaccacccccagucagacagaaagcugaguug


 


ugaguuagccaugugguaggagacagagaccuagguuucugggcuuuguggggugggggauaggaggacacggggaccau


 


uagccuuguguguacuguaugucgccagccgcuguugcugaaggaacuugaagcacaaucgauccaucccagagggacugg


 


aguuaugacaagcuucccaaauauuuugcuuuaucauccgauaucaacacuuguaucuggucucugugucccagcggugcc


 


uugugcaauggcagugugcacgucuaugcuaaaccaccauuuuauuuggucuuuuguuuuguuuugguuuugcucugauu


 


cuugccaaacugagacucuucacuaacggcugggggaaggagcugagugaggcucucauucuuuuugguuuagggauguu


 


uggguuuuuucgucugccucccagaggaccaaugaaaugaagugggcuucccccucuccccuaguuguccaaggguguaug


 


uaguagugggucuuagcuuccuccggcuaagacuuaggcuuccccacccacccaaccccauccccaacggcccuggcucugg


 


gucuggaaagaaggccaccuccagccaguucauacacacaccccuguggcugggagcagggcuggaccgcuuccuucucuuc


 


uuuuuuuggggggggggacacaaaguuucaugcuagaugucguauguauuauaucuauaauauaaacauaucaaacucaa


 









204
AA032310
gaagcucagugucgugaaauggaaaccaaaccuuggagccaucgcugaguauaaaaaaaa




ggaagauuuauauucngcaaagaguagccgaacuggacaaaauuacuucugaaagagaua




auuuuagacaagcauaugaagaucuucgaaaacaaaggcugaaugaauuuauggcugguu




uuuacguaauaacaaauaaacuaaaagaaaacuaccagaugcucacauugggaggagaug




cugaacuggagcuuguggacaguuuagauccuuuuucugaaggaaucauguucaguguuc




ggccaccuaagaaaaguuggaagaagaucuuuaaccucucaggaggcgagaaaacccuua




guuccuggccuuaguguuug


 


205
M94087
Sequence below.







gccgguuugaguugugcgcucgggugucccuuuccucuuccccucccgcagggcuugcggccaccauggcguauuagaggc


 


agcagugccugcggcagcguuggccuuugcagcggcggcagcagcaccaggcucugcagcggcaacccccaccggccuaagc


 


cauggcgcucuucacgaaauccagcagcaguguugcuguaacggacaaagauaccuucgaguuaagcacauuccuggaaucc


 


agcaaagccccacaacaugaccgagaugagcuuccugaacagcgaaguguuggcgggggacuugaugucccccuucgaccag


 


ucggguuugggggcugaagaaagccuaggucucuuagaugacuaucuggagguggccaagcacuugaaaccucauggguuc


 


uccagcgacaaggcgggcuccucggaauggccggcuauggaugauggcuuggccagugccucagacaccggcaaggaggaug


 


ccuuuuccgggacagauuggauguuggagaaaauggaucugaaagaguuugacuucgaugcucuguuucgaauggaugacc


 


uggaaaccaugccagaugagcucuugaccacguuggaugacacaugugaucuuuuugccccucuaguccaagagacuaauaa


 


ggagcccccucagacagugaacccaauuggccaucucccagaaaguuuaauaaaagucgaccagguugcccccuuuacauuc


 


uugcagccuuuccccuguuccccagggguucugucuuccacuccagagcauuccuuuaguuuagagcuaggcagugaaguu


 


gauaucucugaaggagacaggaagccugacucugcugcuuacauuacucuaaucccuccauguguaaaggaggaagacacuc


 


ccucugacaaugacaguggcaucuguaugagcccggaguccuaccugggcucuccccagcauagccccuccaccuccagggc


 


cccaccagacaaucugccuucuccaggugguucccgugggucuccucggcccaaaccuuaugacccaccuggaguuaguuug


 


acagcuaaagugaagacugagaaauuggauaagaagcugaaaaagauggagcaaaacaagacagcagccacuagguaccgcca


 


gaagaagcgggcugagcaggaggcccucacuggcgaguguaaggagcuagaaaaaaagaaugaggcucugaaagagaaggca


 


gauucucuggccaaggagauccaguaucugaaagaccugauagaagagguccguaaggcaagggggaagaagagaguuccgu


 


aauaggguagucaggugcuuugugcuuguacauagucuuguguugcuguguuugcuguaauaaauuauuuuguagugaaa


 


gu


 









206
AI847609
uuuuuuuuuuuuuuuauguagggaaguucauauuuuauuuguccagugacauuuuuuac




aguugaauacaaguuaaaggccugcuugcacaccaaagccagguccuuugggugguucag




ucaaagaaguaaggccuccagcuggcucacaacagaagcggccacuccuuggcccugguuu




gggaacuuuuccagcuuugaguucaucaauaaucucuucaauauccuugggugucagauc




cucauaguaguugucauuuauuugaaccaucggugcauuuacacaggccccuaaacauuc




cacuucuauaagagugaaaaguuugucagguguagucucuccaaccuuuauuccaa


 


207
AI853294
uuuuuuuuuuuuuuuuuggggugaauauagccaaguauuccauuuauuaacaaaauagu




cuuagcaagggagagcucuguucaccccacaagaggccccgcagccgaggccggcccgaag




ccccagcgcugcugcguaagaccgggagggagggaagguguuggggagaagacuuguauu




aagucuuuaauccuagccaccgcaggaacccacggaaaccuaaugccagcuuuggcgauu




gcuggcucaggucugggacauggcgaagggagugcucugauccuagggcucccugagucc




ccagccugcccccaacagagcuccuaaaguugucuggucugcugacuugaggacugguaa




gcuuuggagggauccaucaaggauuccccgaccccaccccuaucgccagggga


 


208
M33934
Sequence below.







ccucugcggcgcgguccucggagcggcgcgguucucggagccacgcgucugucuuccuccguggucauggcggacuaccug


 


auuagcggaggcaccucuuacgugccggacgacgggcucacagcgcagcagcucuucaacugcggggacggccucaccuaca


 


augauuuucucauucuuccuggguauaucgacuucacugcagaucagguggacuugacgucugcucuaacuaagaagauua


 


cacuaaagaccccauugguuuccucacccauggacacugucacagaggcuggaauggccaucgcgauggcgcuuacaggagg


 


uauugguuucauccaccacaacugcacaccugaauuccaggccaaugaaguucggaaagugaagaaauacgaacagggauuc


 


aucacugaccccgugguccuuagccccaaggaucguguacgcgauguuuuugaggccaaagccaggcauggcuucuguggu


 


auccccaucacagauacaggccggauggggagucgauuggugggcaucaucuccucaagggacauugauuuccucaaggagg


 


aagagcaugaccgguucuuggaagagaucaugacuaagagggaagauuugguggucgccccugccggcgucacucugaaag


 


aggcaaaugagauucugcagcgaaguaaaaagggaaaguugcccauugugaaugaaaaugaugagcugguagccaucauugc


 


ccggacagaccuaaagaagaaucgugauuacccccuggccuccaaagaugccaagaagcaacugcuguguggggcagccauu


 


ggcacucaugaggaugacaaguauaggcuggacuuacuggcccuugcugguguggauguagugguuuuggacucuucccag


 


ggaaacuccaucuuccaaaucaauaugaucaaauacaucaaggagaaguaucccagucuacaggucauuggaggcaauguag


 


ucacugcugcgcaagccaagaaccucauagaugcagguguagaugcuuugcgagucggcaugggaagugguuccaucugca


 


ucacccaggaaguguuggccugugggcggccccaagccacagcaguguacaaggucucugaguaugcccgucgcuuuggug


 


uuccuguuauugcugauggaggaauccaaaaugugggucauauugccaaagcuuuggcucuuggggcuuccacagucauga


 


ugggcucccuccuggcugccaccacugaggccccuggcgaguacuucuucucagaugggauccggcugaagaaauaccgagg


 


uauggguucucuugaugccauggacaaacaucucagcagccagaaccgauacuucagugaagcugacaaaaucaaaguggcc


 


caaggaguuucaggggcagugcaggacaaggggucuauccacaaguucguuccuuaccugauugcuggcauccagcauucc


 


ugucaagacauuggugccaagaguuuaacccaagucagagccaugacguacucgggggagcuuaaauuugagaagaggacau


 


ccucugcucagguggaagguggcguccacagccuccauucguacgagaaacggcuuuucugaaaacagauccaguauaugcc


 


uugaauuuuucaauaaaaguuugggaaaaaaaaagugaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa


 









209
X16202
gugugggugcagagcuggggucagggaaagcuggagccuuuugcagacccugagcugcuc




acggcugagagcuggggucauuacccucaccuucauuuccuguaccuguccuucccagag




ccuccuccauccacugucuccaacauggcgaacguagcuguucugguuguccuuggagcu




uggccaucauugcagcugugguggcuuuugugaugaagagaaggagacacacagguagga




aagggcagagucugaguuuuu


 


210
AI661431
acaggaggggaaggccaaagcaagaaugaaagucccccgccccguaucaccacgggcacu




cggggucacccucaggaacaugcagucucugcacgugaggaaagaaacacgcagagaugg




acgagcacuuuuacacccuaauaaaauuagaugcacuaaccacagaccccccu


 


211
AI839109
uuuuuuuuuuuuuuuuuaaaaaaaaaaauggcaucuuuuauucaucaaucccuguuacac




acugaaauacaugcaucuuucuuauguuacuuagcaacguccuuucuauccuuucaccca




uaaaucagucugaugaauucaucuuuaaauucaagaaguuuuucuuuuugaaacgcuacu




uacauuuuauugucucaauaucaaagccaaucuagagauuuauucuuccuacaggugaaa




uagauguuaauacgggaacagucaguacauguucaagaugacaucaaaguuaugcccuaa




gcagauauuucaaggcaauaucaugccacuagcucugagacucuaaguaucacugauagu




acuaaaagguagaagucagcuucaaaaacacacucuugcaauggacacugcucaugaugu




cuaagauuguucacucccacagucaugauuucagaugcacaguuuuuuuugcuuuccuga




gcauucgguuugac


 


212
AI849135
uuuuuuuuuuuuuuuuuaagagugucaccaaagcuuuauuuacaugcgucaucaucucuu




uuacaaacuagauuaugguuuuaaauggaauacacaggcaauaucuacaaacgccacggg




aaguacgcaccuccauuccaccgggaaggggcagauucccaaaucaaacugguuuugauc




cuugagaagaaaggcggcagagcuaacucacggcagcguaugguuagacaagguccucag




uacccagaaugcagcaggauugcgucugccucaaaccagacgaccaacugcugcaggugu




uuaaacauggccacgcgccacacgaaauucuaguuugugugggguagaagcaagaaaaaa




aaaaaaccauggcgccucgugccg


 


213
M32459
gguccggauaguaaacugcucccuuacaucuccuuaaauauaaaguaaggaaaaagaaaa




aacucaguucggguaaccaaguucaacaaguaauccuuggggccgcugugguaucgccaa




aaucuacauaguaucucuuauuaaaauguuuugacgaaaauguaacaauuacgguacuua




augguaacaauguggcugaggaagcaauaguuaacaaagaggagcuaagcuaugcaacaa




accagauuucuauuggucacaaauuugaaguugagaccuguuauccaauuaccaaguacu




uccgcauacaucaucauaggcauuugaagauuucaaccaaucaggagcauguuccuucua




uaaaggaacccagaaccuaaccucugcauuuccuauuucuuuguagaaauggcucguacg




aagcagaccgcucgcaaguccacuggcggcaaggccccgcgcaagcagcuggccaccaag




gccgcccgcaagagcgccccggccaccggcggcgugaagaaaccucaccgcuaccguccc




ggcaccguggcgcugcgcgagauccggcgcuaccagaagucgaccgagcugcugauccgc




aagcugccguuccagcgccuggugcgcgagaucgcgcaggacuucaagaccgaccugcgc




uuccagagcucggccgucauggcucugcaggaggcgagcgaggccuaccuugugggucug




uuugaggacaccaaccugugcgccauccacgccaagcgugucaccaucaugcccaaggac




auccagcuggcccgccguauccgcggcgagcgggcuuaauaggcacgcuuucuacacugg




cacguaaaccaaaacggcucuuuuaagagccaccuccauuauccaccaaagaugcuugaa




guacaaguugugagaguuuucuaggguuuccuauuauagccuuucuugacaaugugagca




ccacccgacgaagcagucugag


 


214
AI841389
uuuuuuuuuuuuuuuuuggacuucugcggcuuuuauuuuugcauguaaaccacugggggg




agggggaucuugauggugggcacccuagagauuacacuggaguuccgagggcuccagaca




cuagcugggaagucaggugacagaaacaaugauucagaccaaucacaugauugcaaaacu




gggucuccagcagggauucugguggucagguguggaugccuaaggaagcagugacauggg




aggggcacgcacugggcuggccuugagcugcugggaugacaucagggauagaggaccuag




cagcugguggcuccagggaucuccgguccaugcuuuauuuggccaggggguuccugaagg




accugccagcaaacuuggcuuugcugcccagcucuuccucaauucugaggaucugauugu




acuu


 


215
X03039
Sequence below.







auucuaaggaucaugucugcgagucaggauucucgauccagagacaauggccccgacgggauggagccggaaggcgucaucg


 


agaguaacuggaacgagauuguggauagcuuugaugacaugaaucucucagagucccuccuccgugguauuuaugccuaug


 


guuuugagaagcccucugccauccagcagcgagcuauucuuccuuguaucaaggguuaugaugugauugcucaagcccagu


 


cugggacugggaaaacagcuacauuugccauaucaauucugcagcagauugaauuagaucuaaaggccacucaggcuuuggu


 


ucuggcacccacacgugaauuggcucagcagauacaaaaggugguuauggcauuaggagacuacaugggugccucuuguca


 


ugccugcauugggggcaccaaugugcgugcugaggugcagaagcugcagauggaagcuccccauaucaucguggguacccc


 


uggccggguguuugacaugcuuaaccggagauaccugucccccaaauacaucaagauguucguacuggaugaagcagaugaa


 


auguuaagccgaggguucaaggaucagaucuaugacauauuccagaagcucaacagcaacacacagguaguuuuguugucug


 


cuacaaugccuucugauguccuugaggugaccaagaaauuuaugagagacccuauucggauucuugucaagaaggaagaau


 


ugacccuggaggguauccgccaauucuacaucaauguggaacgagaggaguggaagcuugacacauugugugacuuguaug


 


agacgcugaccaucacccaggcagucaucuuuaucaacaccagaaggaagguggacuggcucaccgagaagaugcaugcccga


 


gauuucacuguuucugccaugcacggagauauggaccaaaaggaacgagaugugaucaugagggaguuccggucuggcucu


 


agcagaguauuaauuaccacugaccuguuggccagaggcauugaugugcagcaggucuccuuagucaucaacuaugaccuuc


 


ccaccaacagggaaaacuacauccacagaaucggucgagguggucgguuuggucguaaggguguggcuauuaacaugguga


 


ccgaagaagacaagaggacucuucgagacauugagacuuucuacaacaccuccauugaagagaugccccucaacguugcugac


 


cucauuugaggggcuguccugcgaccuggcccuagcccaggguucaguccugggguggggcuaaggaagagcuggaggggg


 


gaggggagggagccaagggauggacaucuuguuuuuguuuuggcuuuuuuuuuuuuuuguuucaguuuuuuuucucuau


 


gaauaaaugucacuuuuugaggc


 









216
AW049795
uuuuuuuuuuuuuuuuugccaggauauauuuauuacugaaaguacaagcaacugagguuu




acccugggaacacccacaaugaaacguguaucuucccuguuucucagaugcugccuccuu




ccacagagugaguuuucguuuaaaacucauaaugaggagaaggcagggggcuccaccccu




uuccuguucaaucugaagacugaauugggcuacacugggauggagauuucaggugcugca




ggucagugucaaccaaggguucgugugucaggaacucuggcugguaagaugacacaaagg




cuucaugcugaagcucagggagguccagggagccuggcagaauggaaucaucauggucau




caucaaacgucugugucuggaaggcuucaaggcucauaauugcaucauucucuggcaguu




ccugagagagcugccccuuccuggguuugcacgcaucaaauuucacccacugguaauuga




cacaguuuugagcuucgggacaacucuuaaucagguuguggaugguuggaugagaaaacc




caaagaagucggcaccgcauga


 


217
D87691
Sequence below.







auuguaacagaagaaggaaaggaaaagaaaguuaacauugacuuugaaccuuucaaaccaauuaauacaucauuguauuugu


 


gcgacaauaaguuucauacagaggcucuuacagcguuacuuucagaugacagcaaguuugguuuuauuguaauagacggaa


 


guggugcucuuuuuggcacgcuccaaggaaacaccagagaaguccugcacaaauucacuguggaucucccaaagaaacacgg


 


cagaggaggucaaucagccuugcguuuugcccguuuaagaauggaaaagagacauaacuauguucggaaaguagccgagacu


 


gcugugcagcuguuuauuucuggagaccaagugaauguggcugguuugguuuuagcuggaucagcugacuuuaaaacuga


 


acuaagucaaucugacauguuugaccagagguugcaaucuaaaguuuuaaaauuaguugauauauccuaugguggugaaaa


 


uggauucaaccaagcuauugaauuaucuacugaaguucucuccaacgugaaguucauucaagagaagaaauuaauaggacga


 


uauuuugaugaaauuagccaggacacaggcaaguacuguuuuggaguugaagauacacuaaaggcuuuggaaaugggagcu


 


guacaaauucuaauagucuaugaaaaucuggauauaaugagauacguucuucauugccaaggcacagaagaggagaaaauuc


 


ucuauuuaacuccagaacaagagaaggauaaaucucacuucacagacaaagagacuggacaggaacacgaacugauagaaagc


 


augccucucuuggaaugguuugcuaacaacuauaaaaaauuuggagcuacacuagaaauugcacagauaagucacaagaag


 


gaucacaguuugugaaaggauuugguggaauuggagguaucuugugguaccgaguagauuuccagggaauggaguaccaag


 


gaggagaugaugaauuuuuugaccuugaugacuacuagguagucgacauggguccggcaaccgugccucacccuccagcau


 


ucaacccaaggagcauacccgugguggaguccaacagaucccugccuuacaauuggagcauuuccagaacuuaauccgugag


 


cauuggauacugaaaagaaaagugaaacaaaaccagacccaacccuacacuuugguuugucguggugucagcgcagcagccg


 


acaacuaagucucu


 









218
AI117211
cagaggagucauuguugcugugguggcuuuugugaugaagaggaggagaaacacagcgua




agccagcugccuggaguggacuaagugacagacaaugucuucacacaucuccugugacau




ccagagcccucaguuuucuuuagucaaguaucugauguucccugugagccuaugggucaa




agugaagaacugugcagcccagccugcccugcacacagaacccugucccugcacugcccu




ggguucccuuccacagccaaccuugcugcuccagccaaacacugggcgacaucugcaucc




ugccagcuccaugcugcccugagcugcagcuccucacuuccacacugagaguaagaaucu




gaaugggaccuugauucuuaacauccugaccgaggguugauuucuuguuaauuucaugga




uugagaauacuuagaguuuugguuugucuugauuuuuuuucaag


 


219
Y00520
ugaauaaaaacgaggagccgaagauucuagggggcuacagcugcgcuuuugcagcacuga




acaugguuccggguacucaagauauugcguuuguguuuggagagguguagauuguagauu




ccagccgagaagaccaggaaaagauaaggauaaagaaugucauauaucucaggagcuaga




ucacuucccgaugaacaaguaagaauugccucaacaaaaauggauggaauuggaccgaaa




aaagccauucagcuucguuaucgauuagguaucagugggaacaucaagaugaaugaguua




acuaaguaucagaucgaccaaauugaacaaaugauagcucaagaucauguuguucauugg




gaauugaagaggggagaacgagcagacaucgaacgauuaauuucuauuucucguuaucgu




ggaauucgucaucaagauggaucgcccuuacgcggucaacgaacucauacuaaugcaagg




acugcucgcaagcaaauucggaaaugaaagaaggcuaccgaaagaacaagcaacggauuu




cgcgcucaucccuugcuaaagcgcauacguuuucuugcuccuugguacuugucugaucaa




ucacacuguucauuaguucacuugauuuuucguucgaugucuugaaccgcuuacuaauca




cguauacguauaguaggcccccuucgccacuccacgucuggcccgucuuggucucgcuca




cuucgcccgccuaucguaucggcucggcuucguccgucaagcgacagcuucugccucuga




cggcuucacuaucgcucaugacugguaguacucuauguaguagucggccuuuguuaagcuu


 


220
AA638002
uauaaccauguuagaagcggaaguuggccugaaaaccugaggcuuaggcuucauagcugg




gcuguagauuggauuuaaacccaguuggagugcaaagucauggugugcucaaggugauga




cagugaacagaguaug


 


221
Z22661
caugggccuccugagaga




uccuuagauccagguuagugcauaggaaaguguccccccacuaccuacagcuaagggauu




gggguggugggaucaugguggagggccguggugaauacuagcgaugucccccgcuacccg




ugcgucugccuccagggugccccuccaaccaggaugaggcucuucaucgcucuuccuguc




cugauuguggucguagccaugaccuuggaagguaagaaagagccuuggaagguaagaaag




augcuuggaagugugaaguuggccuugugccugcggcccaggcuuagaagacccucgagg




agggcucugaggucccuuucugugucaucauuccacuaccgcccucccaucgucccccau




cccaccugccaggugccuuauuuuugugucaaagugggugcugaaggaggcaacucuguc




cagaaaagacgcaguaaccaaugaccuaggauaccacccuuuggaauuggcuaaucuucc




uagaaggggcggacgguaaaaacaaggaggugagaggugcaguaaaaucaaguguccaau




acccucccccaugcuaaugaguuugcucgcaacccucucgcggcaggcccagcccccgcc




caggcggccccggauuuguccggaacauuggagagcauaccggauaaacugaaggaguuu




gggaacacuuuggaagacaaggcccgggcagccauugaacauaucaaacagaaggaaauu




uugaccaagacccg


 


222
X99644
Sequence below.







cagcgccuggggcgcggcgggcgucggcccaggagacgcguggcggcgcucggccucgcggcaucggcggcugccuggccg


 


uuggcggcgagcgcacuugcgccugcgcagcgggguccgugccccuccuccccugggcggcccccccacccccccggcggcg


 


ugugaauggcggccucggcggcagcgacugcagcggccucggccgcgacggccgccucggcggccucugguagcccaggguc


 


gggcgagggcucggcgggcggugagaagcguccggcugcuuccucagccgcggcggccucugcagccgcgucguccccugc


 


ggggggcgguggcgaggcgcaggagcuucuggagcacugcggcgugugucgcgagcgccugcggcccgagcgggauccucg


 


gcugcugcccugucuacauucggccugcagugccugccugggccccgcuacacccgccgcagcgaauaauucgggggauggc


 


ggcucggcgggcgacggcgcuaugguggauuguccagugugcaaacagcagugcuacuccaaagacaucguggagaauuau


 


uuuaugcgugauaguggcaguaaggccucuucugauucccaggaugcuaaccagugcugcacuagcugugaagauaaugcc


 


ccagccacuagcuauuguguggagugcucugaaccacuuugugagaccuguguggaggcucaccagcgggugaaauacacca


 


aggaccacacugugcgcuccacaggaccugcuaagacucgagauggagagcgaacagucuacuguaaugugcacaagcauga


 


gccccucgugcuguucugugagagcugugacacacucaccugccgcgacugccagcucaacgcucacaaggaccaucaguac


 


caguuuuuggaagaugcagugaggaaccaacguaaacucuuggcuucacuggugaaacgucuuggggacaaacaugccacac


 


uucagaaaaacaccaaggagguucgaagcucgauccgccaggugucugaugugcagaagcgagugcagguugaugucaagau


 


ggccauucugcagaucaugaaggagcugaauaagcggggucgaguucuggucaaugaugcccagaaggugaccgaggguca


 


gcaggaacgucuggagcgccagcacuggaccaugaccaaaauucagaagcaccaggaacacauuuugcguuuugccucuugg


 


gcucuggagagugauaacaauacagcucucuugcucucuaagaagcugaucuauuuccagcugcaucgggcccucaaaauga


 


uuguggauccuguggagccucauggugagaugaaguuucagugggaucucaaugccuggaccaagagugcugaagccuuug


 


gcaagauuguggcugagcguccugguacgaacuccacagguccugggcccauggcuccuccaagagccccaggcccucuaag


 


caagcaagguucuggcaguagccagcccauggaaguacaagagggauauggcuuugggucagaugaucccuauucaagugca


 


gagccgcauguaucaggcaugaagcggucccgcucuggugagggagagguaaguggccucuuaaggaaggugccacgugug


 


agccuugaacgccuggaucuggaccucaccucugacagccagccaccagucuucaaggucuuuccuggaagcacuacugagg


 


acuacaaucugauuguuauugagcguggugcugcugcagcagcugcuggucaggcugggacugugccaccaggagccccug


 


gugccccaccccuuccuggcauggccauugucaaggaagaagagacagaagcugcuauuggagcucccccggcugcccccga


 


ggguccugaaaccaagccuguguugaugccucugacugaagguccuggugccgagggaccucgucuagcuucaccuagugg


 


caguaccagcucaggcuuggaggugguggcuccugagguuacuucagccccaguaagugggccagguauccuggaugacag


 


ugccacuaucugccgagucugccagaaaccaggugaccuggucauguguaaccagugcgaauuuugcuuccaccuggauug


 


ccaccucccugcccugcaggauguuccaggggaggaauggaguugcucacucugccacgugcucccugaccuaaaggaggaa


 


gauggaagccucagccuggauggagcagauagcacugguguggugacuaaacucucaccagccaaccagcggaaaugugagc


 


guguucuccuggcccuguucugccaugaaccaugccgucccuugcaucagcuggcuaccgacucuacauucuccauggagca


 


gccuggugguacccuagaccugaccuugauucgugcucgccuccaagagaagcugucaccuccuuauagcucccccaggag


 


uuugcucaagaugugggccgcauguucaaacaguucaacaagcugacugaggacaaggcagauguucaguccaucaucggcu


 


ugcagcgcuucuuugagacacgcaugaaugaugccuuuggugacaccaaguuuucugcugugcugguagaaccaccaccau


 


ugaaccuucccagugcuggccuaaguucucaggagcucucuggcccuggugauggccccugaagcuggggcucuugugguc


 


agcccaguccagcucuggucucuguauuuucaccccauacccuguccuugguggccugacuccuguucuugcuggcccca


 


ucguccccucagucccucuucacaaaaugguuuuuacuucuguggauuuaauaaaaacuucacugagucaguuaaaaaaaaa


 


aaa


 









223
AI843895
uuuuuuuuuuuuuuuuuaaaaauaauuucauuuuuuaauauucuguacaaaauuucucaa




ccuaugaaaauaaaguuugcaaaagucaaaguaguacaugggccugcccuggagccaggc




ccagccggaucuacacuauguacaggucucccagggugagccucagcuagggaaaagcca




cuaaggugccuacagagcaagagggugccaucgggccagugcagccucugcaauuuccag




aucugccacuagaggucggcaugguccugauugcuugucaggcucacccucuggaagacc




acagccaaugacaaagguccucaagggaaagcuuuggggucuagcuggaagugacggugg




guccgccgcccaggcgcaggagcaucugcuggcaguccagcaguaaccggugaucgccaa


 


224
M38724
uccgucguaaccuguugaguaacuauggaagacuauaucaaaauagagaaaauuggagaa




gguacuuacggugugguguauaaggguagacacagagucacuggccagauaguggccaug




aagaagaucagacuugaaagcgaggaagaaggagugcccaguacugcaauucgggaaauc




ucucuauuaaaagaacuucgacauccaaauauagucagccugcaggaugugcucaugcag




gacuccaggcuguaucucaucuuugaguuccuguccauggaccucaagaaguaccuggac




uccaucccuccugggcaguucauggauucuucacucguuaagaguuacuuacaccaaauc




cuccagggaauuguguuuugccacucccggcgaguucuucacagagacuugaaaccucaa




aaucuauugauugaugacaaaggaacaaucaaacuggcugauuucggccuugccagagcg




uuuggaauaccgauacgaguguacacacacgagguagugacgcugugguaccgaucucca




gaaguguugcugggcucggcucguuacuccacuccgguugacaucuggaguauagggacc




auauuugcagaacuggccaccaagaagccgcuuuuccacggcgacucagagauugaccag




cucuucaggaucuucagagcucugggcacuccuaacaacgaaguguggccagaagucgag




ucccugcaggacuacaagaacaccuuucccaaguggaagccggggagccucgcaucccac




gucaagaaccuggacgagaacggcuuggauuugcucucaaaaaugcuagucuaugauccu




gccaaacgaaucucuggcaaauggcccugaagcacccguacuuugaugacuuggacaau




cagauuaagaagauguagcccucuggauggaugucccugucugcuggucguaggggaaga




ucg


 


225
AW122989
uuuuuuuuuuuuuuuuuacuaggcaaagaauuuuauuaacccuuuccaaacuuuauuccc




aggcuucuucagcuuuauuugccgcaaagaaugaauuagguauagcgaaacugaaaaga




gcugcaguguccgggggcuugggcuuaaaaauauuagagaucuagauuuuaucagaucca




uaauaaacaaaaaaauuuuaaaaagcagucaugauauaaaauagcagcuccuguaauuuc




ugcaaguaucaccuucuucagaaguugcuucaauucaguuugccucauucuuagaagccu




caucaaaauucuccaccagaucuggaacuucaucaucaucauccucuccaguagcaaggg




gugcuuuuccauccacagauuguuugggcagagcuucagccagucuccuuaaacuaguca




ggcugucugcaccaagcugguugaggaugcugggaagcauuucugucagcugcuuuguc


 


226
AI844810
uuuuuuuuuuuuuuuuuauucaugcuugccuagggauggggaauagaucauucaauaaaa




acauacaguaaaaacaggggguggggagggggaaggcuuaucauguacaauguuuaaacu




acaauagugauguaccuuaauuacuuccaugcacacaagucuaacauuacaaguuuuuaa




aaaauaaacaccauuaagacuucuaggagcauuuuauaauaaauuccuaauuuuuucuuu




guagauagaucaagcaccuccaaaauacagauuccuauacacagugagcacuuuacuuaa




cguacauggacagccucaggacgagcugacgucucggaucagcucggcaggcaacaaacc




auagugccaaauggaaagaagggcaguugcaaauaaacuuaaaacuaaguuaacuuuuau




aauuaaauacagaaaauauacugauuugcuaaaaauaaauaagaugugauguauuuaaca




cuucacuauaaagaaugaacaccaugacauccucgugccg


 


227
AA940430
agaagaaggaggagugggaccgcaagcaugaggaugcuaguagggaguaugagaaaggca




ugaaagaguaugaaggaggaagaggggacucaucuaaaagggacaagucuaagaagaaaa




agaaaguaaaagcaaagauggaaaaaaaguccacuccuucccggggcucgucauccaagu




cuucauccaggcaguugagugacagcuucaagagcaaagaguuuguguccagugaugaga




gcucuucaggcgagaacaagagcaaaaagaagaggaggcggacgaggacucugaagagga




gcuagccaguaccccuccaagcucagaggacucugccucgggaucugaugaauaaaggag




ggaauucccaccccgucacagcuccagucucucacauaguccuuggauucugugccaucu




gaguaacugcucuugguggcuuccacugcccugaggcuuugagggaag


 


228
M38381
Sequence below.







aucgucguaaucguuugcagacuucucgccgucgccuuguaagcuuugucuucgccuugcaagcuuugucuucaggguug


 


gaaagaugagacauucaaagagaacuuacuguccugacugggaugaaagagacugggauuauggaacauggagaagcagcag


 


cagucacaaaagaaagaagagaucacauagcagcgcccgugagcaaaagcgcugcagguacgaucacuccaaaacgacagaca


 


gcuauuaucuggaaagcagauccauaaaugagaaagcuuaucauagucgacgcuauguugaugaauacaggaaugacuacau


 


gggcuacgagccagggcaucccuauggagaaccuggaagcagauaccagaugcauaguagcaaguccucugguaggagugga


 


agaagcaguuacaaaaguaaacacaggagucgccaccacacaucgcagcaccauucacacgggaagagucaccgaaggaaaaga


 


ucgaggaguguagaggaugaugaggagggucaccugaucugucagaguggagacguacuaagugcaagauaugaaauuguu


 


gauacuuuaggugaaggugcuuucggaaaagugguggaaugcaucgaucauaaagugggagguagacguguagcaguaaaa


 


auaguuaaaaauguggauagauacugugaagcugcucaaucggaaauacaaguuuuggaacacuugaauacaacagaccccc


 


auaguacuuuccguuguguccagauguuggagugguuugagcaucgaggucacauuugcauuguguuugaacuucugggg


 


cuuaguacuuaugauuucauuaaggaaaacaguuuucugccguuucgaauggaucauaucaggaagauggcauaucaaaua


 


ugcaaaucuguaaacuuuuugcauaguaauaaauugacucauacagacuugaagccugaaaacaucuuauuugugaagucu


 


gacuacacagaggcuuauaaucccaaaaugaaacgugaugaacguacuauaguaaauccagauauuaaagugguggacuuug


 


gaagugcaacauaugaugaugaacaccacagcacauugguaucuacaagacauuauagagcaccggaaguuauuuuagcccu


 


cggguggucacagccaugugaugucuggagcauaggauguauucuuaucgaguauuaucuuggauuuacaguuuuuucga


 


cucaugauagcagggaacauuuagcaaugauggaaaggauucuuggaccacuaccaaagcacaugauacagaaaaccaggaaa


 


cgcagauauuuccaucaugaucgauuagauugggaugaacacaguucugcuggcagauauguuucucggcgcuguaaaccu


 


cugaaggaguuuaugcuaucucaggaugccgaacaugagcuucucuuugaccucauugggaaaauguuggaguaugauccc


 


gccaaaagaauuacucucaaagaagcccuaaagcauccuuucuuuuacccacuuaaaaagcauacgugauuuauaaacacagu


 


gcucugaaaggaaucuuacagacuguaucagucuagcuuuuaauuaaguuauuuuguauagcuuaauuuguaaaacauuuu


 


auguuuuuuagaugcuuuauuaaauacauggccaaaccaaauaacaucuuucaguaauuauagaaugauuuauuuggaaua


 


aaauuugugcuuaugaauguaaaaaaa


 









229
AF014371
ggacucgcgacaagcguccucagcgcgaagaggcggacucggaguccucgccuugagccu




ugcaucugagaaguuccagguacuuuguacaacugcaucccagaaccuguguguuuucag




caccuuuauaagugauggcugccaucaggaagaaacuggugauuguuggugauggagcuu




gugguaagacaugcuugcucauagucuucagcaaggaccaguucccagaggucuaugugc




ccacgguguuugaaaacuauguggcggauaucgagguggaugggaagcagguagaguugg




cuuuaugggacacagcuggacaggaagauuaugacugccugaggccucucucuuauccag




acaccgauguuauauugauguguuuuuccauugacagcccugauaguuuagaaaacaucc




cagaaaaauggacuccagaagucaagcauuucuguccaaaugugcccaucauccugguug




ggaacaagaaggaccuucggaaugacgagcacacgagacgggaguuggccaaaaugaagc




aggagccgguaaaaccugaagaaggcagagauauggcaaacaggauuggcgcuuuugggu




acauggaguguucagcaaagaccaaagauggagugagagagguuuuugagauggccacga




gagcugcucugcaagcuagacgugggaagaaaaagucugggugccucaucuugugaagcc




uugugaacgcagccucaugcgguuaauuugaagugcuguuuauuaaucuuaguguaugau




uacuggccuuucauuuaucuauaauuuaccuaaga


 


230
Z30939
uucaagaccgaccugcgcuuccagagcucggccgucauggcucugcaggaggcgagcgag




gccuaccucgugggucuguuugaggacaccaaccugugcgccauccacgccaagcguguc




accaucaugcccaaggacauccagcuggcccgucgcauucguggggagagggcguaaauu




aggguagugagugaauuuggaccccaaaggcucuuuucagagccacccacauuuucuaua




aaaggcuguauaucgauaagcuuuuauaaaccccacucagcaacucc


 


231
U28208
uuaugugauaaaaaaauucaacuugguauuaacuuaacuaagggccuuggugcuggugcu




uugccugauguugguaaaggugcagcagaagaaucaauugaugaaauuauggagcauaua




aaagauagccauaugcucuuuaucacagcagggauggguggugguacuggaacaggugcu




gcaccgguaauugcaaaagcagccagagaagcaagagcgguaguuaaagauaaaggagca




aaagaaaaaaagauacugacuguuggaguuguaacuaagccguucgguuuugaaggugug




cgacguaugcgcauugcagagcuuggacuugaagaguugcaaaaauacguagauacacuu




auugucauucccaaucaaaauuuauuuagaauugcuaacgagaaaacuacauuugcugac




gcauuucaacucgccgauaauguucugcauauuggcauaagaggaguaacugauuugaug




aucaugccaggacugauuaaucuugauuuugcugauauagaaacaguaaugagugagaug




gguaaggcaaugauugguacuggagaagcagaaggagaagauagggcaauuagugcugca




gaggcugcgauaucuaauccauugcuugacaauguaucaaugaaaggugcgcaaggaaua




uugauuaauauuacuggugguggagacaugacucuauuugaaguugauucugcagccaau




agagugcgugaagaaguggaugaaaaugcaaauauaauauuuggugccacuuuugaucag




gcgauggagggaagaguuagaguuucuguucuugcaacuggcauugauagcuguaacgac




aauucaucuguuaaucaaaacaagaucccagcagaggaaaaaaauuuuaaauggccuuau




aaucaaauuccaacauuagaaacaaaagaauaugcuucaacugag


 


232
AV218217
ugaucaggucacauuccggugccuuccacccccuauggcacgggcgccccgccuugccau




accacagcucccuccaggcuuagaccuggcuucaccgcauuucaggugcuauaccccccc




cugcuuuuccccccauugcccuuaaaugccccucggccccuccauccccccggaacaggg




uggcacuugccacucucaggaccaccuugccaaggagaauaaaccgaauccuguugcu









Thus, the transcripts identified in this Example, the proteins they encode, and the pathways in which the proteins participate contribute significantly to HF stem cell activation. Accordingly, anagen can be induced by activation of these transcripts, proteins, and pathways.
Example 9
Molecular Pathways Activated During Induction of Epidermal Cells to Differentiate into HF Stem Cells
The gene expression pattern of HF stem cells was analyzed as described in Example 8 and compared to non-bulge basal keratinocytes. 157 genes were differentially expressed in the HF stem cells, as assessed by microarray analysis and quantitative polymerase chain reaction (qPCR). A group of selected genes with increased expression in HF stem cells is depicted in Table 4. A group of selected genes with decreased expression in HF stem cells is depicted in Table 5.







TABLE 4







Genes up-regulated in HF stem cells. Numbers in parentheses are


the fold increase as determined by quantitative real time PCR.










Gene Name/





Protein name/
Fold




GenBk Acces #.
Incr.
Sequence
SEQ ID No.










Cell surface proteins










Cd34/Cd34
43
uuuuuuuuuuuuuuuuucacucaucacguuuauucagaagagaauacacccaa
233


antigen
(189)
uccucucaucucuggaaaguuuuguuccuagccaucauuaagaucaggacccc



AI847784,

uguucuccccuuaaccccaggagaggaagcuuauagucuuuguagauauucug



AI173145

aaccucugaucacaaaggguuauaaaauagugaagggguuuggacuaggaaag





gcacagacugaaaggaaucugccaggggacugaggccacagcucccccaggag





ucagaggaagggggaagucacguauuuuauagaaggccaagggccucagagca





agaguauuccuuugaagagcuca



 







Calcium-related










S100a4/S100A4
35
ugguggagcaggucucaggaaucucuucgcuucagcuucaaucauggccugug
234


(mts)
(144)
gucuggucgccagcaaccugaaucucaaaccuggggaaugucucaaaguucgg



X15986

ggagagguggccucggacgccaagagcuuugugcugaaccugggaaaagacag





caacaaccugugccuacacuucaauccucgcuucaaugcccauggagacgcca





acaccauuguguguaacaccaaggaagaugggaccuggggaaccgaacaccgg





gaaccugccuuccccuuccagcccgggagcaucacagaggugucaucaccuuu





gaccaggcugaccugaccaucaagcugccagacggacaugaauucaaguuccc





caaccgccucaacauggaggccaucaacuacauggcggcggauggagacuuca





agauuaagugcguggccuuugagugaagccagccagccuguagcccucaauaa





aggcagcugccucugcu



 







Transcription Factors and related genes










Id2 helix-
11
gugguucuucggcgccagguucgcccgcuucugcccuuagguaacauucucua
235


loop-helix
(25)
aacugcguuucucucccaaucuuuugcaggcauuuggggacuuuuucuuuucu



protein

uuuuacuuucucuuuuucuuuugcacaagaagaagucuacaagaucuuuuaag



AF077861

acuuuuguuaucagccauuucaccaggagaacacguugaauggaccuuuuuaa





aaagaaagcggaaggaaaacuaaggaugaucgucuugcccaggugucuuguuc





uccggccuggacugugauaccguuauuuaugagagacuuucagugcccuuucu





acaguuggaagguuuucuuuauauacuauucccaccauggggagcgaaaaggu





uaaaaaaaagaaaaaaaucacaaggaauugcccaauguaagcagacuuugccu





uuucacaaagguggagcgugaauuccaggaggacccaguauucgguuacuuaa





augaagucuucggucagaaauggccuuuuugacacgagccuacugaaugcugu





guauauauuuauauauaaauauauauauauugagugaaccuuguggacucuuu





aauuagaguuuucuuguauaguggcagaaauaaccuauuucugcauuaaaaug





uaaugacguacuuaugcuaaacuuuuuauaaaaguuuaguuguaaacuuaacc





cuuuuauacaaaauaaaucaaguguguuuauugaauguugauugcuugcuuua





uuucagacaaccagugcuuugauuuuuuuuuaugcuauguuauaacugaaccc





aaauaaauaccaguucaaauuuauguagacuguauuaagauuauaauaaaaug





ugucugacaucaa



 


Id4
4
cgaugaaggcggugagcccggugcgccccucgggccgcaaggcgccgucgggc
236


AJ001972
(12)
ugcggcggcggggagcuggcgcuacgcugccuggcggagcacggccacagccu





ggguggcucggcagccgccgccgccgcugcggcggccgcgcgcugcaaggcgg





ccgaggcggcggccgaugagccggcgcugugccugcagugcgauaugaacgac





ugcuacagucgccugcggaggcucgugccuaccaucccgcccaacaagaaagu





cagcaaaguggagauccugcagcacguuaucgacuacauccuggaccugcagc





uggcgcuggagacucacccugcuuugcugagacagccgccaccgcccgcgcca





ccucuccacccggccggggcuuguccggucgcgccgccgcggaccccacucac





cgcgcucaacacugacccggugagaagccuuggcgggcacccugggcaucgcg





ggaaagguggcggggcggcgagauacggguggucuugcuccucucagggaaug





acagccgcuucucccgucuccaccgagagccgccugcugggcuuggugaucca





cuggucccugagccgagggcgguugggcuuggagcccugcgucuccggagugu





cccuugcaucacaggaggcuuccccagcuucgggcucggguggggacucugcu





caugcgcacucuaaccgcuuuuccccuugguguuggguugcuguuccaggaug





cgcacucuaaccgcuuuuccccuugguguuggguugcuguuccaggccggcgc





cgugaacaagcagggugacagcauucucugccgcu



 


Peg3/
12
Sequence below.
237


Paternally





expressed gene





3 zinc finger





protein





AF038939










acuagucucgaccauguaccaucacggagacgacaccaacagugacaugaacagugacgacgacaugagccgaagugggagagaa


accccacccccucgaccaucucaugcuuuuggcagugagcgagaccuggagcgcaggggcagaagcagagauguggagccucgag


accgcuggccauacaccaggaaucccagaagcaggcugccucaacgggaucuuucucuuccugugaugucaagaccacauuuugg


acuggacagagaugaugacagacguuccauggauuaugagucucgaucccaggaugccgagucauaccagaauguuguggaacuc


aaagaggacaagaagccucagaauccaauucaggacaaccuggagaacuacagaaagcugcucucgcugggaguccagcuugccg


aagaugaccgacacucucacaugacacaaggccacucaucgagguccaagagagcugccuacccaagcaccagccgaggucucaa


acccaugccugaggccaaaaagccaucccacaggcgugggaucugugaggacgagucuuucucauggagugauaauggaaaaauu


caucaaggauguggcucgcaaccccaaauccggaagagcaagggagcugaacgagcguccuccuccaagguuccccaggccuaau


gauaacuggaaggacaguuccuccagcagaagagagucagugauccaggagagggguuaugaagggagcgcauuuaggggcggcu


uccgguucaacgcagaccuggcuuccagaagcagagcucuagaaaggaagaggcguuaccacuuugauucugaugagcgggguuc


gggccaugagcauaaaagcugugugaggaagaagccuuuugaguguggugcugagaugagacaggcuaugagcaugggcaaccug


aacagcccuuccuucucugagucgcagucaaucgauuuuggggccaacccauacgugugugaugagugcgggaggcaguucagug


ucaucucugaguuuguugagcaccagaucaugcacacuagggagaaccucuaugaauauggagaguccuuuauucauagcguggc


ugucaaugaggugcaaagaagucaggguggggggaaacgcuuugaguguaaggaauguggagaaaccuucaguaggagugcugcc


cuggcagagcaccgccaaauccaugcuagagaauaucuugcagaauguagagaucaggaggaugaggagaccaucaugccuagcc


cgaccuuuagugagcugcagaagauguauggcaaagauaaguucuaugagugcaaggugugcaaggagaccuuucugcacaguuc


cgcccugauugagcaccagaaauccaugguagaggcaacucagaugacagagauaaugagcgugaacgcgaacgugaucgucuac


gugcacgugcacgagagcagcgugagcgcgaacgugaacgggagcgugagcgugagcuuggggaacccuuucugaccuguccaaa


cuucaaugaguuucggaagauguacaggaaagacaaaaucuaugagugcaaaguguguggggagagcuuucuucaucucucaucc


cugagggagcaucagaaaauccauacuagaggaaacccauuugaaaauaagagcaggaugugcgaggagaccuuugucccuaguc


agucucuccgacggcgccagaaaacuuacagagagaagcuguucgacuuuaacaaugccagggaugcacugaugggaaacucaga


cuccagcgagcaucagaaaaaccguucccgaaggaacuucuuugagggcagaggauuugagaaacccuucguugaaucucagaag


agucauacuauaacaagaccaccugaaaacaaagacgaugacaagccguucacaaucagugucaacccuaaugacaagcugaaac


uccccaucauggaaaauggcucccagggcaaauccugugagaggucuguuauucauagcuugggcuccgcagaagcucagaagag


ucaugguggacugggguucaguaaaccaagaccaguggcagagucuagcacccagagcucaagcagcauuuacuaccccagagca


cacucuggaggcaacaccuaugaaggaaaagaauacaaggacucuaucauccauagcuugccagcuccucgaccucugaaacguc


auagagcaaaugaccauauucaaugugaugaggggggagaauccuccauuuauaucccagauauuauuaauaagggaaggaagau


uccugccagagaagaugcuuaugaaggaaguagcagcagcaacuaccacacaccaaauguaucccgugcugagccuccaagucuu


ucuggagagucccaugacucuaagcaggaugucacguuuucaguucccagcucaaguguucgugaacaccagaaagcucgugcca


aaaagaaguacauugagcccaggaacaacgagaccucuguuauccacucccuaccuuuuggugaguugcuugcaggucaccguag


ggcaaaguucuuugagugucaggaaugcggggaggccuuugcucguaggucugagcucauugagcaccagaagauucaugauaga


gaaagaccuucuggaagccgacauuaugagcgcucugucauccgcagccuugcgcccagugacccucagaccaguuaugcccaag


aacguuucauccaagaacaagugcguaaauucagagcguuuggacaacgcucaacuaccagcaacaaccucaguguacagaaaau


cuaugcccaagagacauuuaaugccgaggagccccaugauaaagaaacucauggucaaaaaauucaugacaaagagccauauggu


aaggagcccaguggcaaggagccccauggugaugagccccaggacaaagaaccccuuguucaggagaugcgcagugaagagcccc


augaugauaagccccauggccaggagccccaugaugauaagccccauggccaggagccccaugaugauaagccccauggccagga


gccccacggugaugagccccauggccaggagccccacggugaugagccccaugacaaggaacccauugaucaggagaugcgcagu


gaagagccccacagugaagagucucauggugaugagccccauggugaagagucccauggccaggagaaaguugaagaugcuacca


uucaggccucaguuucugaagagcaucagaaagaugacgcuggugaugcaaucuaugaaugccaggacugugggcugggcuuuac


ugaucucaaugaccucacaagccaccaggacacccauagcagaaaggcucugguugacagucgugaauaugcacauucugaaguu


caugcccacuccgucagcgaauuugagaaaaaaugcucuggagagaaacuauaugaauguccaaaauguggggagucuuucauuc


acagcucguuacuuuucgagcaccagagaguucacgaacaagaccagcuguauuccguaaaggccuguuaugacgcuuucaucgc


ucuguugcccguuagaccaaggagaaauugcacuguugaaaggaauccugccguuucugggucagccauucgaugccgucagugu


ggacaaggcuucauucacaguucugcccuaaaugagcacaugagacagcacagagauaaugaaauaauggaacagagugagcuuu


cagaugagauuuucauucaaggccuagcccucacugaguaucaggggagugaaacagaagagaagcuuuucgagugcacaaucug


uggggaaugcuucuucacugccaaacagcucggggaccaccacaccaaaguucacaaggaugagcccuaugaguaugggcccucc


uacacccaugccuccuuucucaccgagccccucaggaagcacaucccacuguacgaaugcaaagauugcggccaguccuuccuag


acgacacugucaucgcugagcgcaugguguuucauccugagcgagaaggugggucagaaauaguagcugccacugcccaagaggu


cgaagccaauguccucaucccacaagaaguacugcgaauccaggggucaaaugcagaagcugcugagcccgaaguggaggcugca


gagcccgagguggaggcugcagagccugagguggaggcugcagagccuauuggagaggcugaagggccagauggagaagcugcug


agccugauggcgaggcugagcagcccaauggagaggcugaacagccaaacggugaugcugacgagccagacggagccgggaucga


agacccagaagagagagcugacgagccugaggaagacgucgaagagccagagggagaugcagaugagcccgauggugcagacauu


gaagacccagaagaggaaggagaagaucaagagauugagguugaagaaccauacuacaacugucaugaaugcgcagaaacguucg


cuuccagcucagccuuuggcgagcaucugaaaagucacgccagugugaucaucuucgagccggccaaugcuccuggagagugcuc


uggcuacauugaacgggccagcaccagugcagguggugcggagcaggcagacgacaaguacuucaaaugugaugugugcgggcaa


cucuucaacgaccgccucucccuugccagacaccagaauucucacacugguugaguaaccaggcugaagaaaagaagagcaaagc


caaaccuucuucccagaaccagacccuuaauaaaucacaaagagagccuaaaccaacccauaaugucuauaagaaauucaccuuc


cuguauacauaccggacuucacaucaaagacuuucacucucaucacagacugaaaaaagaaaagacauugaacgcagggacucuu


ucaguuuuagcuguucccuauggaacaucaguguauauuugggaaagcuagagugaacaucuacaucuuccauuucaucuaagua


acuagauugagggaaaccuagugacaauuccagaccacagagguugccccagucgacuguaaaugauaccccuuucauacccuau


acauaaugauuccugccauguauauaaaugagcaaaucagugauacauauauuuggauuuagugugcuauagaauuuacaguuua


cucuacagagcuaccuagccugguacucugauuuuuucccugaggaggaagagagcaacaauuuagcauauauuuguaaguauug


uccaugcagaagcuuuucugugcaucauuugaaccccauuaguauccuuuccaguaauggaguguucuguccccuaccucuuaga


uaguccugugaaggugugggugugaaagaucgugugucuuugaauccuggcuguguggaaacaggcauuuuagcuucuacagcca


uuuggugugcacccagaccccuugagacugauuguguaacccuuuacaauauauggauuugucucugugacccaaauacaaccca


ucccuacauuuauauaccuuacagugguuuucuugc


 


Growth Factors, Receptors and Related genes










Fz2/
9
uuuuuuuuuuuuuuuuuaccguucuuuauuuaaaaaaauaaaauaggaguccg
238


Frizzled 2
(17)
uagggugcacccuccccccuccugagugaaggagggcacggugcaguccggac



AW123618

cugggagaggggaaagcccggcaggcaggcgagaccgcuucacacaguggucu





cgccaugccggcuguuggugagacgaguguagaacuuccuccacgagugcagu





gucuugccggaccagauccagaagcccgacgugaugcccacgaugagcgucau





gagguauuugaucauguagacugugaagucgggcgacaugcggggcguguagu





gggccgggcaggggauggcuaggcucuugcagugcuggcuuacccaggagcgc





ucccagugcucgcggaaggccugcucauagaaguagcaggcgaug



 


Dkk3/
6
Sequence below.
239


Dickkopf3
(22)




AJ243964










ggccgcgucgacgccucuccagcugcucuguggcagcccagcuaccggucgugaccagauccagcuugcagcucagcuuuguuca


uucgaauugggcggcggccagcgcggaacaaacaugcagcggcucggggguauuuugcuguguacacugcuggcggcggcggucc


ccacugcuccugcuccuuccccgacggucacuuggacuccggcggagccgggcccagcucucaacuacccucaggaggaagcuac


gcucaaugagauguuucgagagguggaggagcugauggaagacacucagcacaaacugcgcagugccguggaggagauggaggcg


gaagaagcagcugcuaaaacguccucugaggugaaccuggcaagcuuaccucccaacuaucacaaugagaccagcacggagacca


gggugggaaauaacacaguccaugugcaccaggaaguucacaagauaaccaacaaccagaguggacagguggucuuuuucugaga


cagucauuacaucuguaggggaugaagaaggcaagaggagccaugaauguaucauugaugaagacugugggcccaccagguacug


ccaguucuccagcuucaaguacaccugccagccaugccgggaccagcagaugcuaugcacccgagacagugagugcuguggagac


cagcugugugccuggggucacugcacccaaaaggccaccaaagguggcaaugggaccaucugugacaaccagagggauugccagc


cuggccuguguugugccuuccaaagaggccugcuguuccccgugugcacaccccugcccguggagggagagcucugccaugaccc


caccagccagcugcuggaucucaucaccugggaacuggagccugaaggagcuuuggaccgaugccccugcgccaguggccuccua


ugccagccacacagccacagucugguguacaugugcaagccagccuucgugggcagccaugaccacagugaggagagccagcugc


ccagggaggccccggaugaguacgaagauguuggcuucauaggggaagugcgccaggagcuggaagaccuggagcggagccuagc


ccaggagauggcauuugaggggccugccccuguggagucacuaggcggagaggaggagauuuaggcccagacccagcugagucac


ugguagaugugcaauagaaauggcuaauuuauuuucccaggaguguccccaaguguggaauggccgcagcuccuucccaguagcu


uuuccucuggcuugacaagguacagugcaguacauuucuuccagccgcccugcuucucuggcuugggaaagacaggcauggcggg


uaagggcagcggugagucgucccucgcuguugcuagaaacgcugucuuguucuucauggauggaagauuuguuugaagggagagg


augggaaggggugaagucugcucaugauggauuugggggauacagggaggaggaugccugccuugcagacguggacuuggcaaaa


uguaaccuuugcuuuugucuugcgccgcucccaugggcugaggcaguggcuacacaagagcuaugcugcucuguggccucccaca


uauucaucccuguguuucagcuccuaccucacugucagcacagcccuucauagccacgcccccucuugcucaccacagccuagga


ggggaccagaggggacuucucucagagccccaugcucucucucucaaccccauaccagccucugugccagcgacagcccuuccaa


auggagggagugaaauccuuugguuuuauuauuuucuccuucaaggcacgccugccacuaaggucaggcugacuugcaugucccu


caacguucguagcagugugguggacacugucuuccaccgacugcuucaauaccucugaaagccagugcucggagugcaguucgug


uaaauuaauuugcaggaaguauacuuggcuaauuguagggcuaggauugugaaugaaauuugcaaagucgcuuagcaacaaugga


aagccuuucucagucacaccgagaagucacaaccaagccagguuguguagaguacagcugugacauacagacagaagaaggcugg


gcuggaugucaggccucagaugacgguuucaggugccaggaacuauuaccauucuguaucuauccagaguuauuaaaauugaaag


uugcacacauuuguauaagcaugccuuucuccugaguuuuaaauuauauguauacacaaacauguggcccucaaagaucaugcac


aaaccacuacucuuugcuaauucuuggacuuuucucuuugauuuucaauaaauacaaauccccuucaugcaaaaaaaaaaaaaaa


 










Sfrp1/
6
Sequence below.
240


Secreted





frizzled-related





protein 1





U88566










gcacgagcagcccgcagcccgccgcgccugugcgagccgggacagcacucggccccgcgcgcuccccgccccgcgccagccccgc


cgcggcgaccugcugcagcggaggaccccaucgaucggagacccggggagcagcgcgcagcccgcgagccgacgggccccgacug


cgucuuuguccccggaggcuccgggaaguuugcagcgggacgcgcgcgugaaggcagcgugggcagccccgacgucgccgagcaa


caugggcgucgggcgcagcgcgcggggucgcggcggggccgccucgggagugcugcuggcguuggccgccgcucugcuggccgcg


gguucggccagcgaguacgacuacgugagcuuccaguccgacaucggcucguaucagagcgggcgcuucuacaccaagcccccgc


agugcguggacaucccgguggaccugaggcugugccacaacgugggcuacaagaagauggugcugcccaaccugcuggagcacga


gaccauggcagaggugaagcagcaggccagcagcugggugccgcugcucaacaagaacugccacaugggcacccaggucuuccuc


uguucgcucuucgcgcccgucugucuggaccggcccaucuacccgugucgcuggcucugcgaggccgugcgcgacucgugcgagc


cggucaugcaguucuucggcuucuacuggcccgagaugcucaaaugugacaaguuccccgagggcgacgucugcaucgccaugac


cccgcccaauaccacggaagccucuaagccccaagguacaaccguguguccuccaugcgacaacgaguugaagucagaggccauc


auugaacaucucugugcaagcgaguuugcacugaggaugaaaaucaaagaagugaagaaggaaaacggugacaagaagauugucc


ccaagaagaagaaacccuugaagcuggggcccaucaagaagaaggagcugaaggcgcuugugcuguuccugaagaacggugccga


cugucccugccaccagcuggacaaccucagccacaacuuucucaucaugggccgcaaggugaagagccaguaccugcugacagcc


auucacaagugggacaagaaaaacaaggaguucaaaaacuucaugaagagaaugaaaaaccacgagugucccaccuuccagucug


uuuuuaagugauacuggggcggacuggggaaggggaguguggcuuggggugagggugggggcgcguggaugacccuggcucuung


gggcucacauauugcucucacccauacaguuguggcuuuugcauugcaccuggcucuguuccuacagcgaacccucucccuuncc


uccauagccacauccagcuaaggccacggccuuuagauuaggaaggcuuuuuuuuuuuuaagggcugcagcagggccagcagcga


cgugcaaaaggagaggcagaauccuuucacugagccuggggcacaaaaaacagaaaauguunnccgguuuggaaaaacaaaacaa


aacggauuguaaagaacugcagacggacagcugcucagcucaacguuguucgggacaucauuaccaauugcuuguggagucuaag


ccucuacagguagaagagucugaucauugccaagccaggcugcuuucaguuuauuauuaaucccccucuuucugccuuagauaga


ccaucgccaccuucaaaacacacacacacacacacacacacacacacacacacacacacacacacacacacacuucugaaaguag


ccaggguaucccaguauagaacgggauagcuaaggguuugggugggaggccacugcuacucuaccuucagcuuuugaacuggcca


ccuuugauaggaaacugaggucucagauggacacuucuaccaguccaucgggauacaaggaugccaggcaagggucugcuuuugu


cugaaggagguacgugggcaugaagagacaugaggcauuucaggcugagaagcaacagcuacuaguuuucaacaauagaguggaa


gaaaugagcaaagguagaaaugucaagcaggucacaagucagggugauugggggaauccugugccaacagccucacuuuguaauu


ccaucugucacuuucaaaagaacagcagcauaagacagggauaaaagcccacauacccuccaaggcuugaguaaaaguccacacu


cagcauuucaaagacuaacgucguugacugcccaaggcugcccucuuaauacaccgccuaugcaugugcuguggaaggcaacucu


gugcaugugcuguggaggagaugggccucauggcugugcuggcugcccggaaucaguauagcguggaaggagacaguauccauag


acucugcuuuucugcaaggaaagcccuuuuccuuauacaugauugccuauaauucagacaaauuuaaaaucgcugccugccugag


cccuccaccuuuacuuuugcauucuccggucauauucuuuugaggcuaaagugcccuauccgaggagaugguuucaaaggcuaac


uaaucugcagcuuuucccaagugcccagagguauuucucaaaguugguaugcuuaauaagugauguaaauauuccaguucucuua


ggcagccuuacuccuguugucccug


 










Dab2/Disabled
15
Sequence below.
241


homolog 2





U18869










aauuccgaguggccgcgcggcuauuuaaguggcguuacuccgcguccucggcgcugcagccuugaggcuucgggcgcgggggaag


ucaugcuggcuccacagaagcacuagcuaguccguguacuuuguggguucuguccuuuugagaccugcccgccggggauuggcug


guaucagugacugucuacugcuggauuuucugcuugccuucccgucaugucuaacgaaguagaaacaagcacaaccaauggccag


ccugaccaacaggcugccccgaaagcgccaucaaagaaggagaagaagaaagguucugaaaagacagacgaguacuuguuggcca


gguucaaaggugaugguguuaaauacaaggccaagcuaaucgguauugaugaugugccugaugcucgaggagacaaaaugaguca


ggauucuaugaugaaacucaagggaauggcagcagcuggucgcucucagggacaacacaagcaaagaaucugggucaacauuucc


uugucuggcauaaaaaucauugaugagaaaacugggguaauugaacaugaacauccaguaaauaagauuuccuucauugcucgug


augugacagacaacagagacauuugguuauguguguggaggugaaggccagcaucaauuuuuugcuauaaaaacagggcaacagg


cugagccauuagucgucgaucuuaaagaccuuuuucaaguuaucuauaauguaaagaaaaaggaagaagauaagaaaaagguuga


agaagccaacaaagcagaagagaauggaagugaggcccuaaugacccuugaugaucaagcuaacaaauugaagcuggguguugac


cagauggauuuguuuggggacaugucuacaccuccugaccuaaauaguccaacagaaagcaaagauauccuguuaguggaucuaa


acucugaaaucgacaccaaucagaacucuuuaagagaaaauccauucuuaacaaauggagucaccuccuguucucucccucgacc


aaagccucaggcauccuucuugccugagaacgccuuuucugccaaucucaacuucuuucccaccccuaacccugauccuuuccgu


gaugaucccuuugcacagccagaccaaucggcacccucuucguucgauucucucacaucuccagaucagaagaaagcgagucuga


guagcucgucuacuccacagaguaaagggccccugaacgucgauacugauuacuuuggucagcaauuugaccagcucucuaaccg


gacuggcaaaccggaagcucagggaggcccguggcccuacccaaguucgcagacccagcaagcagugagaacucaaaauggggua


ucugaaagagaacagaacggcuuccauaucaaaucuuccccgaacccuuuugugggaagcccucccaaaggacuaucgguaccga


auggcguaaagcaggacuuggaaaguucuguccaguccucagcacugacuccauagccauuaucccaccuccacaaaguaccaaa


ccaggaagaggcagaaggacugcuaagucuucagcaaacgacuugccugcuucagacaucuuugccucagaaccuccaggccaga


ugucccccacaggacaaccugcagucccgcagucgaacuuccuggaucucuucaaaggcaaugcuccucccccaguggggccccu


uguaggucuagguacggucccaguaacacccccccaagcaggacccuggacgccuguugucuacaguccuucgacaacugugguc


ccaggagccauaauaaguggccagccucccaguuuucgccagccacucguuuuugguacaaccccagcaguacaagucuggaauc


agucuccaucauuugcaaccccagcuuccccuccaccccccacaguuugguguccuaccacaucuguggcgcccaacgcuugguc


auccacaagcccucuggggaauccuuuucagaguaauaauaucuuuccaccucccaccauguccacucaguccucuccucagccu


augauguccucuguucuggccacaccgccucaaccaccuccccgaaauggcccacuaaaggacauucccagugacgcuuucacug


gcuuagacccccuuggggauaaagaggucaaggaagugaaagaaauguuuaaggacuuccagcugcggcagccaccucuuguucc


cucaaggaagggggagacgccucccucugggacuucaagcgccuucuccaguuacuucaacaauaaaguuggcauuccucaggag


cauguagaccaugaugauuuugaugccaaucaacuguugaacaagauuaaugaaccaccaaagccagccccgagacaaggugucc


ucuuggguaccaagucugcugacaauucacucgagaacccuuucuccaaaggguucagcucaucaaaccccucugugguuucuca


gccugcaucuucugauccccacaggagcccuuucggaaauccuuuugccuagcuucugaaguuguaaugaugacuauccagauga


gcaaaagacuggcuuuggucaagaaugaagcagacagccagaaacauguugaccucuguccucgcuccagcuuugacguauuauc


uguuacccuauuuguuuuggccucuuguacuuguaaaaugccuuucauuuuccugucuaggcuaaagcuaaacuuaaacuauggc


uuuacguaaauuaagcuccuaaacucucuagcuccaauauaaaugaaguagcuucccuaucaaaucccugucuguugugcccccu


ugaaacuuccagaauauucuccauucuacccuccauuugggaggagcggcuaccuuuacccuuaauaucacacugccuugaguca


auguccaaauacucauagcucucaaagucauuugggguuccuggugugcggccuaaaccuaaagcauccuauuaauagggaagua


agacaccuugcuuccuauguccacucagggagaauuuuauuuaauaaaaugaaagcaagacuaacuucucaaauccacccaagga


ccauuuugagauggucguuucucagcuaacugcaccauuuaccaauccugccccaaguggugcuuacauuugacuugaagaagag


aaagagcuaacucaaaacacaaggcauuauucaaagcuaauaaaacaauuucucccuggggccccacauuguuuucauuccagau


acguugcagcuguuugacccugaugacauuaugcccuacauuuuccuugaagauccugauuuuauuucaugugauuuuuguuucu


caauaaagaugauuauugugugcacggaauuc


 










Cktsf1b1/
12
Augaaucgcaccgcauacacugugggagcguugcuucuccuccuggggacccu
242


Gremlin,
(12)
acugccaacagcugaggggaaaaagaaagguucccaaggagccauuccgccuc



Cysteine knot

cugacaaggcucagcacaaugacucugagcagacccaguccccaccacaaccu



superfamily 1,

ggcuccaggacccgggggcggggccaggggcggggcaccgccaugccuggaga



BMP antagonist 1

ggaggugcuugaguccagccaagaggcccugcacgugacagagcgcaaguauc



AF045801

ugaagcgagauuggugcaaaacucagccccugaagcagaccauccacgaggag





ggcugcaacagccgcacuaucaucaaccgcuucuguuauggccagugcaacuc





cuucuacauccccaggcacauccgaaaggaggaaggguccuuucagucuugcu





ccuucugcaagcccaagaaguucaccaccaugauggucacacucaacuguccu





gagcuacagccacccaccaagaagaaaagggucacacgcgugaagcagugccg





uugcauauccaucgacuuggauuaa



 


Fgfr1/Fibroblast
10
Sequence below.
243


growth factor





receptor 1





U22324










guggaauauccauggagguacggagccuuguuaccaaccuuuaaccgcagaacugggauguggggcuggaagugccuccucuucu


gggcugugcuggucacagccacucucugcacugccaggccagccccaaccuugcccgaacaagcucagcccuggggagucccugu


ggaaguggagucucuccugguccacccuggcgaccugcuacagcuucgcugucggcuucgcgaugaugugcagagcaucaacugg


cugcgggauggggugcagcugguggagagcaaccguacccgcaucacaggggaggagguggaggugcgggacuccauccccgcug


acucuggccucuacgcuugcgugaccagcagccccucuggcagcgauaccaccuacuucuccgucaaugucucagaugcacuccc


auccucggaagaugaugacgacgacgaugacuccuccucggaggagaaagagacggacaacaccaaaccaaaccguaggccugua


gcucccuacuggacauccccagagaaaauggagaagaaacugcaugcggugcccgcugccaagacggugaaguucaagugcccgu


cgagugggacacccaaccccacucugcgcugguugaaaaauggcaaagaguuuaagccugaccaccgaauuggaggcuacaaggu


ucgcuaugccaccuggagcaucauaauggauucuguggugccuucugacaagggcaacuacaccugcaucguggagaaugaguau


gggagcaucaaccacaccuaccagcuugacgucguggaacgaucuccgcaccgacccauccuucaggcagggcugccugccaacg


agacaguggcccugggcagcaauguggaguucauguguaagguguacagcgauccgcagccucacauucaguggcugaagcacau


cgaggugaacgggaguaagaucgggccagacaacuugccguauguccagauccugaagacugcuggaguuaauaccaccgacaag


gaaauggaggugcuucaucuacggaaugucuccuuugaggaugcgggggaguauacgugcuuggcggguaacucuaucggacucu


cccaucacucugcaugguugaccguucuggaagcccuggaagagagaccagcugugaugaccucaccgcucuaccuggagaucau


uaucuacugcaccggggccuuccugaucuccugcauguugggcucugucaucaucuauaagaugaagagcggcaccaagaagagc


gacuuccauagccagauggcugugcacaagcuggccaagagcaucccucugcgcagacagguaacagugucagcugacuccagug


cauccaugaacucugggguucuccugguucggcccucacggcucuccuccagcgggacccccaugccggcuggagucuccgaaua


ugagcucccugaggauccccgcugggagcugccacgagacagacuggucuuaggcaaaccacuuggcgagggcugcuucgggcag


gugguguuggcugaggccaucgggcuggauaaggacaaacccaaccgugugaccaaaguggccgugaagauguugaaguccgacg


caacggagaaggaccugucggaucugaucucggagauggagaugaugaaaaugauugggaagcacaagaauaucaucaaccuucu


gggagcgugcacacaggaugguccucuuuaugucauuguggaguacgccuccaaaggcaaccuccgggaguaucuacaggcccgg


aggccuccugggcuggaguacugcuauaaccccagccacaaccccgaggaacagcugucuuccaaagaucugguauccugugccu


aucagguggcucggggcauggaguaucuugccucuaagaaguguauacaccgagaccuggcugcuaggaacguccuggugaccga


ggauaacguaaugaagaucgcagacuuuggcuuagcucgagacauucaucauaucgacuacuacaagaaaaccaccaacggccgg


cugccugugaaguggauggccccugaggcguuguuugaccggaucuacacacaccagagcgauguguggucuuuuggagugcucu


ugugggagaucuucacucuggguggcuccccauaccccggugugccuguggaggaacuuuucaagcugcugaaggagggucaucg


aauggacaagcccaguaacuguaccaaugagcuguacaugaugaugcgggacugcuggcaugcagugcccucucagagaccuacg


uucaagcaguugguggaagaccuggaccgcauuguggccuugaccuccagccaggaguaucuggaccuguccauaccgcuggacc


aguacucacccagcuuucccgacacaggagcuccaccugcuccucaggggaggacucugucuucucucaugagccguuaccugag


gagcccugucugccucgacaccccacccagcuugccaacaguggacucaaacggcgcuga


 










Fgf1/Fibroblast
10
auggcugaaggggagaucacaaccuucgcagcccugaccgagagguucaaccu
244


growth factor 1

gccucuaggaaacuacaaaaagcccaaacugcucuacugcagcaacgggggcc



M30641

acuucuugaggauccuuccugauggcaccguggaugggacaagggacaggagc





gaccagcacauucagcugcagcucagugcggaaagugcgggcgaaguguauau





aaaggguacggagaccggccaguacuuggccauggacaccgaagggcuuuuau





acggcucgcagacaccaaaugaggaaugucuguuccuggaaaggcuggaagaa





aaccauuauaacacuuacaccuccaagaagcaugcggagaagaacugguuugu





gggccucaagaagaacgggagcuguaagcgcgguccucggacucacuauggcc





agaaagccaucuuguuucugccccucccggugucuucugacuag



 


Gpr49/G protein-
63
Sequence below.
245


coupled receptor
(377)




49 FEX





AF110818










auggacaccuccugcguccacaugcuccuguccuugcuggcgcugcugcaguugguggccgccggcagcucaccgggaccagaug


cgauaccgcggggcugcccaucacacugucacugugagcuggauggcaggaugcugcucaggguggacugcucggaccuggggcu


cucggagcugcccuccaaccucagcgucuucaccuccuaccuggaccucaguaugaacaacaucagucagcuacccgccagucuc


cuacaucgccucugcuuccuagaagaguuacgucuugcuggaaaugcuuugacacacauucccaagggagcguucacgggccuuc


acagccucaaagugcuuaugcugcagaacaaccagcugagaaagguuccggaggaagcgcuacagaauuugagaagccuucaauc


ccugcgccuagaugccaaccacaucagcuacgugccacccagcuguuucagcggccugcacucccugaggcaccuguggcuagau


gacaaugcucucacagacgucccuguccaggcuuucagaaguuuaucagcccugcaagccaugaccuuggcccugaacaaaauac


accacauagcagacuacgccuuuggaaaccucuccagccucgugguucugcaucuccauaauaauagaauccacucccugggaaa


gaaaugcuuugauggacuccacagccuggagacuuuagauuuaaauuauaauaaccuugaugaauuccccacugcaaucaagaca


cucuccaaccuuaaggaacuaggauuccacagcaacaacaucaggucaauaccggagcgagcguucguaggcaacccuucucuua


ucacaauacacuucuaugacaaccccauccaauuuguuggaguaucugcuuuucagcauuugccugaacuaagaacacugacuuu


gaauggugccucgcacauuacugaauuuccucacuugacaggaacugccacccuggagagucugacuuuaacuggagcaaagauc


ucaucucuuccccaggccgucugugaucaguuaccuaaucuccaagugcuagauuugucuuacaaccuacucgaagacuuaccca


guuugucaggcugccaaaaacuucagaaaauugaccugaggcauaacgagaucuaugaaauuaagggcagcacuuuucagcaguu


guuuaaccuccgaucucugaacuuagcauggaauaaaauugcuaucauucaccccaaugcguuuucuacguugccgucucuaaua


aaguuggaccuaucauccaaucuccugucguccuucccuguacuggguuacaugguuuaacucacuuaaaauuaacagggaaccg


agccuuacagagccugauaccaucugcaaacuucccagagcucaagauuauagaaaugccaucugcuuaccaguguugugcauuu


ggggggugugagaaugucuauaaaauuucuaaccaauggaauaaagacgacggcaacaguguggacgaccuucauaagaaagacg


cuggguuauuucaaguucaagaugagcgggaccuugaagauuuccuacuugacuuugaggaagaccugaaugcccuucacucggu


gcagugcucgccuuccccaggucccuucaagcccugugagcaccuauuugguagcuggcugauccgaaucgggguguggaccacg


gcaguacugacgcuuuccugcaangccuugguggcuuugaccguguucagaacuccccuguacaucucuuccauaaagcugcuaa


uugggguaaucgcgguaguggacauucucaugggggncuccagugcugugcuggcugccguggaugcauucacuuuuggccguuu


ugcucagcacggugcguggugggaagacggaaucggcugccaaaucguuggcuuccuguccauuuuugcuuccgaaucgucgauc


uuccugcucacucuggcagcgcuggaacgagguuuuucugucaagugcucuucgaaguuugaagugaaagcuccccuuuuuagcc


ngagagcgauguuuugcuauguguccuguuggcccugaccaungccacaauccccuugcuaggaggcaguaaguacaaugccucu


ccccucugccugcccuugcccuuuggggagcccagaccacgggcuacaugguggcucucguguugcucaacucucucuguuuccu


cauaaugaccauugccuacacaaagcucuacugcaguuuggagaaaggagagcuggagaaucuuugggauuguucgauggugaag


cacauugcucuguugcucuucgccaacugcauccuuuacugccccguggcuuucuuauccuucuccucuuugcuaaaccucaccu


uuaucaguccugacgucauuaaauuuauacuucucgugaucgucccacuuccuuccugucucaacccacuucucuacauugucuu


caauccccauuuuaaggaggauaugggcagccugggaaagcauacccguuucuggaugagaucaaaacacgcgagucugcugucc


auuaacucggacgaugnugagaaacgguccugugagucaacccaagccunaguauccuuuacccacgccagcauagccuaugacu


ugccuuccacuuccggggcaucaccagcuuaccccaugacugaaagcugucaucucucuucaguugcauuugucccaugucucua


gugacuaugagagaggaacguuuuuaagaguuggaaaccugaaaagugauuucuaucagagcaguagcuaagaaaagcugagcua


aaaaccuaccuuaaaacccaagcaaacaucucnaaauugguguggaaacaguggugccuuagagcaggagagcaucauuaaacac


cgcuuguaucauuuguucagcuaagaaggaaagccaucaagucacuuaggugaacccagaugagaaaagcagccugaaaugcucu


ucgcauuguagucucuucugacucaccagcauagucucccauagugagaagacncguuggaugacucaauggguguauuuaaauc


cacaaauuccuuguuuaaaagguuagaguuuuaagaaaaaaaaaaaaaaaaa


 










Igfbp5/
37
Sequence below.
246


insulin-like





growth factor





binding protein 5





L12447










uuuuuuuucuucaccuccucccuuuucaaggccuccaagcuaauuauuucuguugcuuuggagugagcaauucugugguucucuc


caccaccacccccaauucugacccgaucccgccuggggguuucuacggucuccgcucacucugcgugcaccuggcgcgccucuuu


uuuucacccccaaccuguugcaagucuuuaauccucgcaauugggacuugcgugcaggcaccugaauccuccuugccucauanuu


ugcaaguguuugggggagagcaccugcucuaccugcaagagauuuaaaaggaaaaaaaucuccaggcucccucuuucuccacaca


cucucgcucuccugccccgccccgagguaaagccagacuccgagaaaauggugaucagcgugguccuccugcugcuggccgccua


ugccguaccggcucaaggccuggguucuuucgugcauugugaacccugcgacgagaaagcucuguccauguguccccccagcccu


cugggcugugagcuggucaaagagcccggcuguggcugcugcaugacuugcgcccuggcggagggacagucguguggugucuaca


cagagcgcugcgcccaggguuugcgcugccucccccggcaggaugaggagaagccgcugcacgcccugcugcacggccgcggggu


uugccucaacgaaaagagcuacggcgagcaaaccaagauagagagagacucucgggaacacgaggaacccaccaccuccgagaug


gcugaagagaccuacucccccaaggucuuccggcccaagcacacucgcauuuccgagcugaaggcugaggcugugaagaaggacc


gcagaaagaagcugacccaguccaaguuuguggggggugcagagaacacugcccaccccagagucaucccugcaccugagaugag


acaggaauccgaacaaggccccugccgcagacacauggaagcuucccuccaggaguucaaagccagcccacgcauggugccccgu


gcuguguaccugcccaacugugaccgcaaaggauucuacaagagaaagcaguguaagcccucccguggccgcaaacguggcaucu


gcugguguguggacaaguacggaaugaagcugccgggcauggaguacguggauggggacuuucagugccacgccuucgacagcag


uaacguugagugacgcguccccucccuuccucccccuauccuacccccccagccccaacuccagccagcgccucccuccacccca


ggacgucacuacauuucaucucauuuaggggaaauauauauacauauauauuugaggaaacugaggaccucggaaucucuagcaa


gggcuaaggagacacuccccaccaugaccccggaaauguauuccuuuuugaagcaaguugaacggacagagaagggaaggagaga


agaagcaagagggagcgagagauggaaagaaagcaaagcguuggaauagaggaaaagagggaaggacagauaggauuagagagag


aagagagaaacagcaaggcagaaaggacuccacaaccaaggcugaaucugcccuuuugcuuucagcucuagccuggggucagaaa


aaguguggcauucagugacacccaguuuagauuggucaaggggagaaaagaaacaaggugugucagugccucucgggucuguccc


cuccugcagccagcaguguggauggcuagaccccucacccuccucuccucuuacccaagugcagggugauuucauccccaaauuu


acaaagacuaaaaugcauuccaucccucugaaaauaaacaaaagugagugauugaagauagguuuucccccagcagacaagugaa


cucagaaugugugcaaauuuuacucuuguuaaagauuuuuuuaagaagucaguacgcacccccaacacuggaaagacuugauucu


ccagggugacaagcaauucagaagcgcguggcuucggcccuugauuucacuagacucaaagcuggcccggcagccucuguggagg


aggaugagagguggagaaaaccaaggggcuuguacucacccacaagacuccauguagacuuuauaggcauauaaaucuauuuucu


uuaccuuuuuuucccuuucccuuucuuucgaaguuuugcauuaccucuuuaaaguaguuuuuuuuaggacacugaagaucuuccu


cauucugggaaaaauccauauuucacaaauacaacccagaacgccagcuuggccugcguccaggcagccuuucucgugagcuaca


aguguggcucuuuuguggggcaccgauuuggaucuucucaugauuccaaacguguguugaagugaauccaccaagccagguaacu


gccagcacccaagggugcaucaagugcauagcccaggucaccccauuucagccuuccaacccgcagaaaguaacugucucacacc


acaccacauaaaccugccagauccaucuguaacccacuggccugcccagaccuuuuuuucccaucugcauuuuuuuuuuugaacu


gcauuuugaaagccucccucagaugccaggcugacagaucagagagaaacuaacaugagagaugacagaggaggaggaaguggag


ggugggggcagagacuuccacagagagacauagaagauggagcagaggucuggggguggggaggacaagaaagagacagagagag


gaaaauaccaauagaauuuuccuuggugucucccaucuaaucaacucucugagauuugagaggaaaaagaaggcaggggaagaac


uugagguagaaaugaggucaguucaagucacagggcccagaugguggguaacugaggcaggauccagacuugagacacacgguug


gaaacaaggcugguuagccugacuggguauugaagggugaagaggaugccuuggaaagacagcacaacuucaguucaacuucagg


cccccaaggaggaacugaggccaaagaauccuucaagugcuucaugagucuccucugcccgacucaaacauccuucccugugaug


gaggaugguagaaagcccaggacaacucaggcccggaucuucacgacuguugucauuugccagccugauuuugauccaagagaag


caucucauugcccacuggcuucuucaacaaagaggugcuuaacaaaaggcucaggacuaucuuugaagacugaagauaaccuucc


aggagaggagacucggacauugguacaggaggccccuuuuggcgggggacacagcucuuugcgcucucuugauggcauggcauag


uagaggcccccuccaacccggaacauggagcaacacaaagggagagcaaagaaacugacgugcgucgacucauaggacaugggug


gcugcgggcacagaaagggaugccuccuguugccuggacaggacaguuggcugggaaggaaagagaaaauugaucuucauaagac


aaagggccugaugggauggcaauagaaggacuuaccagaccugcagggucaguauacccaucaccccgcacaacauccccagccc


ccaacucaaacuucaauauaucuuaggccaguauccuagaccuaagucucuccuuucugccauuauuucuccgcaucuugagcag


ucaucugacugagauuugccaaguggauacugggguaccacugccccccaagaaaagacugagccaggaacugccuacucgcucc


cccucccgagccuggagcuaacuccugugaggggugcucucuucaccccacaacuuacuagaccuugagugagccucugucccuu


augugggcucuucgcugugagccacagauggaggucauuguauagacaguuagccuuccccaggucagccuaccucccccaaacu


ugugagucuccccgcugcucauauggagaggcaugucuaagacagcaagucuucuagaggaagcuugccuuuaacagacagaugg


aacuaaaccuuccaaaugggagaucuggcugaacccaggauacagagaccauggacauggauggggucaucaagagaagagggau


guccuucuccagguuagggagagagaaggcaaguuugcaacgaucccaucaugcccugagcaagaagcuuuuggcccaggcuagc


cuuuaacuccauuagaggccucucuguuggguuuauccacagcaguaggcccaaguauggccuguccccaccucuacuaucccgu


ggaagguuucuucccaccccuuuuugacaaaugccucacucgagcaguggaaagauagcucucuucccccucuucugccagguaa


caaagagaccuaaccaggaccuauucuccaccccagccagucuugaccagccagaacaaagcagggaaccuggagaauaaaagac


ucuacguuccucugacaaagacucuacguuucucugacggccaggccuaaacagacaaggcuugggaacaucugccccacaggau


acggaggaggucagcugugcucacuccucuucuccuuccaagacccucuuccgaccaugacuuaucuccaugguaacauccucac


caucauucucccacuaccaaggguugccauggcaaccucccaaccaccugcccaucccaggcaggcagcuguccuucugcucaga


acccuagaggacucuaggugaaauuuuacagcuuaagagaggagugagccaaggagaagagacccuguaguccucuggcuuucaa


gagaaagaaggcuaugauuuaaaacacaguagaagggaaagaggucucgucgaggucgaccucucccggggagcuuagggguugu


acugucuuuauuuuuuaaaccacuaaagugcaaunuuuccugcacucuuguuaccccgccucucuucccuguuagguuuucauuu


ccuugagcagacuuucuugguuuuuuaauggaguauagacuuucaccacuucacagacucuggccuccucuccaagucucucugg


auggggaaaaggaagguagagggucagaggggaaggggucccucgucaccccgcauccauucacccccacuucucuggucccuag


ucaccggcuucaccccnaucuccgacaccaucacugucacacaguagccugucacacggauaguacaguucagacaagacuccuu


cagauuccgagacgccuaccgguuguuuuugguuuuuguuuuguuuucuuuuguuuguuuguuuguuuguuuuuuacaacagcaa


uaaccacaucacauauuacuguagcucucuauaguguuacguucagacaccguagcucuguccucucuuauuuuguugguuuuga


cuuaaaaaaaaauacuuaugcuuuuuacuggugaaacagauugaaaaaaaaauugaacaacaaaccaguuugugaaaaaaaaaaa


aaaugugaaaaaaaaucaccccgauguggaagagcucggcuccucuuuagcauuuuguacuuaaggaaauaaaaaagaaaaaccu


ggaagaucucacauuuuauuacaaagugaaaaaaaaa


 










Myoc/trabecular
111
Sequence below.
247


meshwork induced





gluco-corticoid





protein





AF041335










guccagucugcagucuguauucggaagacauagauacuaaauacauggcaacucuuuuuuuuguuuguuuuaauucaucaggaug


uggagcgcuagucuggguaggagagccagucacccugaggacagcugaaacaaucgcuggcaaguauggaguguggaugagagac


cccaagcccacccaccccuacacccaggaaagcacauggaggauugacacgguuggcacagagauccgccagguguuugaguaca


gucagauaagccaguucgagcagggcuauccuuccaagguccaugugcucccucgggcacuggagagcacgggugcuguggugua


ugcggggagccucuauuuccagggggcugaguccagaacuguggucagguaugagcuagacacggagaccgugaaggcagagaag


gaaauuccuggagcuggcuaccacggacacuucccguacgcgugggguggcuacacagacauugacuuagcuguggaugagagcg


gccucugggucaucuacagcacggaggaagccaagggggccauaguccucuccaaauugaacccagcgaaccuggaacuugagcg


uaccugggagacuaacauccguaagcagucuguggccaaugccuuuguuaucuguggcaucuuguacacggugagcagcuacucu


ucagcccaugcaaccgucaacuucgccuacgacacuaaaacggggaccaguaagacccugaccaucccauucacgaaucgcuaca


aguacagcaguaugauugacuacaacccccuggagaggaagcuguuugccugggacaacuucaacauggucaccuaugauaucaa


gcucuuggagaugugaggagccucuaugccuaccagcaaaggccagaaaaggugaaguuccgggcucccgggugaagcagcuguc


agcagaggcagccagaugcauggaguuucuccuccugcuaaagauuuuguuuauccgggucaauguacagcuagcuccccucuga


cugacacguccuccaggcuuguauagucgcauagacucuguucucuucugucagcuuucaaagggcuguuccucuuuuaaaaauc


acauagug


 










Itm2a/E25
30
Sequence below.
248


putative





Integral membrane





protein 2A





L38971










gggagaccugagcucgcugcugccuguggaagacugggagaggagacacuaagugcgcucaagcaagcgcgauccucuccucuuu


caaccugcagcccaagauacugauucgagccgcgccuuaccgcgcagcccgaagauucaccauggugaagaucgccuucaacacc


ccuacggcggugcaaaaggaggaggcgcggcaagauauagaggcgcucgucagucgcacuguccgagcucaaauccugacuggca


aggagcucagaguugucccgcaggagaaagauggcucaucugggagaugcaugcuuacucuccuaggccucucauucaucuuggc


aggacugauuguugguggagccugcauuuacaaguacuucaugcccaagagcaccauuuaccauggugagaugugcuucuuugau


ucugaggauccugucaauuccauuccuggaggagagccauacuuucugccugugacugaggaggcugauauccgugaggaugaca


acauugccaucauugaugugccugugcccaguuucucugauagcgauccggcggcaauuauucacgacuuugagaagggaaugac


ugcuuaacuggacuugcuuuugggaaacuguuaucugaugccccucaauacuuccauuguuaugacuccaaagaaucugguggaa


cuuuuuggaaaacuggcaaguggcaaguauuugccucauacuuaugugguucgugaagaccugguugcuguggaagaaauucgug


auguuaguaaccuugguauuuuuauuuaccaacuuugcaacaaccgaaaauccuuccgccuuagacgcagagaccuucugcuggg


uuucaacaagcgugccauugacaaaugcuggaagauuagacacuuccccaaugaauuuaucguugaaaccaagaucugucaggag


ugaaaugugacagauaaagaguauccuugauaauaagaagucaggaacuuaccgucugacuuggaaaauugaaauugaugggaua


cucaugcuauuuacucauacauuuacucuauugcuuauacuggaaaaggaaagggaaaggggggagaaaacuacuaaccacugca


agcgauuguccaauucuacuuuaauugacauugcuugcuguuuucaacaagucaaaugauuaucuuuucucuugaauuuauaggg


uuuagauuucugaaagcagcaugaaugugucaucuuaccauccugacaauaaagcccauccucugguuuuauuuaaagcaagcuc


uuuccaacaucacuuggcuagagcaugcuuuaaauuuaaaauauuugaaauuuguuuuugacauuuuuuugugugaaacauguca


aaucucuuaccauucuuugguuuucuucuuuauuauguucaacucuccugauuucagaaguuacauuuuugcauuucuaucaggu


gcuguguaacgaaucugacugauaugugaacaaucuucaugaggaagcaauuuuuuacucauguaaugauucuuucucacugaua


ucuguauugugaaauccacagaacuguacaggugcugaaugcuguaaggaguucugguuguaugaauucuacaacccuauaauaa


aguuuaccguauucaauca


 










Eps8/epidermal
15
Sequence below.
249


growth factor





receptor pathway





substrate 8





L21671










ggccauuaccaaucgcgacccgcgcacacacggcccgggcggcgggcgaagcgggcucccggggcgcugggcgcagggcgcgggg


caagccccagcagcgugucugcaacggggcgcggcgggcgcuccagcuccgggaucuuucucccucggucaccucccucgcgucu


agggaggucguggcacucccugaggagcgcggcugcucggagggcggauccuagaacagaggcgugagagccggcaugaaugguc


auaugucuaaccgcuccaguggguauggagucuacccuucucaacugaaugguuacggaucuucaccacccuauucccagaugga


cagagaacacagcucaagaacaagugcaaaggcccuuuaugaacaaaggaagaacuaugcccgagacagugucagcagugugucg


gacgugucccaguaccgcguggaacacuugaccaccuucgugcuggaucggaaagaugcaaugaucacugucgaggacggaauaa


gaaagcugaaguugcuggaugccaagggcaaaguguggacucaagauaugauucuccaaguggaugaccgagcugugagccugau


ugacuuagagucaaagaaugaauuggagaauuuuccucuaaacacaaucucgcauugucaagcaguggugcaugcaugcagcuau


gacuccauucucgccuugguaugcaaagagccaacgcagagcaagccagaccuucaccuuuuuccagugugaugagguuaaggca


aaccuaauuagugaagauaucgaaagugcaaucagugacaguaaaggugggaaacagaagaggcggccggaggcccugaggauga


uugccaaagcagauccuggcaucccuccuccucccagagcuccugccccugugccaccggggacugucacacagguggacguuag


gagucgcguagcagccuggucugccugggcagcugaccagggugacuucgagaagccccggcaguaccacgagcaagaagagacg


cccgagaugauggcagcccggaucgacagggaugugcaaaucuuaaaccauauuuuggaugacauugaauuuuuuaucaccaaac


uccaaaaagccgccgaagcguuuucugagcuuucuaaaaggaagaaaaguaagaaaaguaaaaggaaaggaccuggagagggcgu


uuuaacacugagggcaaaaccgccaccuccugacgaguuuguugacuguuuccagaaguuuaaacauggauucaaccuucuggcc


aaguugaagucccauauccagaacccgagugcuucagaucugguucauuuuuuguuuacuccacuaaauauggugguccaggcaa


cagguggcccugaacuggccaguucgguacucagcccacuguugacaaaagacacaguugauuucuuaaacuacacagccacugc


ggaggaacggaagcuguggaugucacugggagauaguugggugaaagugagagcagaguggccgaaagaacaguucaucccaccu


uacgucccgagguuccgcaacggcugggagcccccgaugcugaacuucaugggcgcgcccacagagcaagacauguaucaacugg


ccgaguccguggccaacgcagaacaccagcgcaaacaggacagcaagaggcuguccacagagcauuccaauguguccgacuaucc


uccagccgacggauaugcguacaguagcagcauguaccacagaggaccacaugcagaccacggggaggcugccaugccuuucaag


ucaacuccuaaucaccaaguagauaggaauuaugacgcagucaaaacacaacccaagaaauacgccaaauccaaguacgacuuug


uggcgaggaacagcagcgagcucucgguuaugaaagaugaugucuuagagauacucgacgaucgaaggcagugguggaaaguccg


gaaugccaguggagacucuggguuugugccaaauaacauucuggauaucaugagaacuccagaaucuggaguggggcgcgcugac


cccccauacacacauaccauacagaaacaaaggacggaauacggccugagaucagcugacacuccuucugccccaucacccccuc


caacgccagcacccguuccggucccccuuccaccuucuguaccagcacccguuucugugcccaagguuccagcagaugucacccg


ccagaacagcagcuccagugacagugggggcagcauugugcgggacagccagagauacaaacaacucccaguggaccgaaggaag


ucccagauggaagagguucaggaugagcucuuccagaggcugaccaucgggcgcagugcugcgcagaggaaguuccacgugccac


ggcagaacguuccagugaucaauaucacuuaugacuccucaccggaagaaguaaagacuuggcugcagucaaagggauucaaucc


cgugacugucaauagccucgggguguugaacggagcacaacucuuuucucucaacaaagacgaacugaggucugucugcccggaa


ggugccagagucuuuaaccaaaucacuguucagaaagcugcuuuggaggacaguaauggaagcuccgaguuacaagagaucaugc


ggagacggcaggagaagaucagcgccgcugcgagcgacucgggaguggagucuuuugaugaagggagcagccacugaguccauga


acuuccuuauucuugguguggucguugaacagugauggacaugcuuuguuuuaagaagccuugaagggaaugucaaagcugucgu


cuugguauauguaauuuaucgccauauaaggaaacaguauaugccugaguaagcagaggacccgcugcuucugugcacauuaguu


ugauuaaaacugagaagcggguaggugagauggcucagcaaguaaaggugcuugcugccaagcccaaugacccaaguucgagucc


cugggucuacaugguaggagagagcuggcuucugcaaguuguccucugaccaccacacauaaauaaauaacaaauguaauuuaca


aacuuuuaaaagaaaauguaauuuaaaaaaccagacguucuagacuguucugggcuugggaauauuuuuuucacuuuccuaaggu


guacuuuccuuugcuacauuaauuauugcagccuuguucgaugaucuaaguggggauauuugacaauggcagauuuauucauugc


aacaaggaaagacacagccauugaugaaaaaaaaaagaaagucucagcuuucagugacugggauaccugcuguccagggaggagg


cucaguuagacuacccucugcuuacuugaggucugacaugcccaaugagaguguauuuagcuuuauuuaaaguucuuaaugccaa


caguuuuaaaaaucacauuuaaaugaacuguacaagguagccagaccuugaauguaugaauagacuauauaauaugucccgagaa


acuuuguuacucucagcucuguugauugcgaaaucuugcauagauuaugcuuugauuuaguuucu


 










Fyn/Fyn
10
Sequence below.
250


proto-oncogene





M27266










ccugggccccgccgcggacgcgcggagccgccugggccgcgccggaggagggcggggagaggaccaugugaaugugcuccggagc


ugagcgccaagccaagcaguguuugaaaggaacaggaugcugaucuaaucguggcaaaaagucaguccgaccgcugguuucgaag


acaugugguguauauaaaguuugugauaguugguggaaauuugggagcuuggauaaugggcugugugcaauguaaggauaaagaa


gcagcgaaacugacagaggagagggacggcagccugaaccagagcucuggguaccgcuauggcacagaccccaccccucagcacu


accccagcuucggcgugaccuccaucccgaacuacaacaacuuccacgcagcugggggccagggacucaccgucuuugggggugu


gaacuccuccucucacacugggacccuacgcacgagaggagggacaggagugacacuguuuguggcgcuuuaugacuaugaagca


cggacggaagaugaccugaguuuucacaaaggagaaaaauuucaaauauugaacagcucggaaggagauuggugggaagcccgcu


ccuugacaaccggggaaacugguuacauucccagcaauuacguggcuccaguugacuccauccaggcagaagagugguacuuugg


aaaacuuggccgcaaagaugcugagagacagcuccuguccuuuggaaacccaagagguaccuuucuuauccgcgagagccaaacc


accaaaggugccuacucacuuuccauccgugauugggaugauaugaaaggggaccacgucaaacauuauaaaauccgcaagcuug


acaaugguggauacuauaucacaacgcgggcccaguuugaaacacuucagcaacugguacagcauuacucagagaaagcugaugg


uuuguguuuuaacuuaacugugguuucaucaaguuguaccccacaaacuucuggauuggcuaaagaugcuugggaaguugcacgu


gacucguuguuucuggagaagaagcuggggcagggguguuucgcugaaguguggcuugguaccuggaauggaaauacaaaaguag


ccauaaagacccuuaagccaggcaccaugucuccggaguccuuccuggaggaggcgcagaucaugaagaagcugaagcaugacaa


gcuggugcagcucuacgcggucgugucugaggagcccauuuacaucgucacggaguacaugagcaaaggaaguuugcuugacuuc


uuaaaagauggugaaggaagagcucugaaguugccaaaccuuguggacauggcggcacagguugcugcaggaauggcuuacaucg


agcgcaugaauuauauccacagagaucugcgaucagcaaacauucuaguggggaauggacuaauuugcaagauugcugacuuugg


auuggcucgguugauugaagacaaugaauacacagcaagacaaggugcgaaguuucccauuaaguggacagcccccgaagcggcc


cuguauggaagguucacaaucaagucugacguauggucuuuuggaaucuuacucacagagcugguacaccaaaggaagagugcca


uacccaggcaugaacaaccgggaggugcuggagcagguggagagaggcuauaggaugcccugcccacaggacugcccgaucuccc


ugcacgagcucaugauccacugcuggaaaaaggauccggaagagcgcccgaccuucgaguacuugcagggcuuccuggaggacua


cuuuacggccacagagccccaguaucagcccggugaaaaccugugagagccugcgcuucagacgccucuucccgaggccucccua


ccccuccccauuagcuuccaauucuguagccagcugccccagagcaggagaaccguccaggaucagauugcaugugacucuugaa


gcugaacuuccacggcccucauuaaugacacuugucccccaguccgaaccuccucugugaaccaucugagacagaacguguuauu


ucucagacuuggaaaugcauuguaucgauguuaugucaaaggccaaaccucuguucaguguaaauagcugcuccugugccaacaa


ucccagugcuuuccuuuuuuaaaaaagaaaaagcaaauccuaugugauuuuaacucugauuucaccugauucaacuaaaaaaaaa


aaaguauuauuuuccaaaaguggccucuuugucuaaaacaauaaaauuuuuuuucauguuuuaacaaaaaaaaaaaaaaaaaaaa


aaaa


 










Col6a1/
36
Sequence below.
251


Procollagen, type





VI, alpha 1





X66405










cccucccuggcucucuccucagcucugggcucugacugcagcaagcagagacaaccucucacucucgccuuucccagcgcccacc


cugacccuggcccacauuugacggugacucgcaggccagccagaaacaugaggcuggcccacgcucugcugccccugcugcuaca


agccugcuggguggccacacaggacauccagggcuccaaagcgauugccuuccaagacugcccuguggaucuauucuucgugcuc


gacaccucggagaguguggccuugaggcugaaaccuuauggggccuugguggacaaggugaaguccuucacuaagcgcuucauug


acaaccugagagacagguacuaccggugugaccgcaaccugguuuggaaugcgggugcgcugcacuacagugacgagguggagau


cauccgagggcucacgcgcaugcccaguggccgcgaugagcucaaggccagcguggaugcggucaaguacuucgggaaaggcacc


uacaccgacugcgccauuaagaaggggcuggaggagcugcucauagggggcucccaccugaaggagaacaaguacuugaucgugg


ugaccgacgggcauccucuagagggcuacaaggaaccaugcgggggucuggaagaugcaguaaaugaggccaaacaccugggcau


caaggucuuuucuguggccaucacaccugaccaccuggagccacgucuaaguaucauugccacagaccacacauaccggcgcaau


uucacggcagcugacugggggcauagccgcgaugcagaagaggucaucagccagaccauugacaccauuguggacaugauuaaaa


auaacguggaacaaguguguuguucuuuugagugccaggcugccagaggaccuccagggccccgaggcgacccuggguaugaggg


ggagcgaggaaagccaggucuuccgggagagaagggagaagcuggagacccuggacgaccuggggaucuuggaccagucggguac


caggguaugaagggagaaaaggggagccguggagagaaggguuccagaggaccgaaagguuacaagggcgagaaaggcaagcgcg


gaaucgacggggucgacggcaugaagggagagacgggguacccaggacuaccgggcugcaagggcuccccaggauuugauggcau


ucaaggacccccgggucccaagggugaugcuggugccuuugggaugaagggagaaaagggugaagcuggagcagacggugaggcu


gggagaccagggaacucagggucaccuggagaugagggugauccuggagagccugguccccccggagaaaaaggagaggccggug


augaaggaaaugcuggcccagacggugccccuggagagagggguggcccuggugaaagaggaccucgggggaccccuggugugag


aggaccaaggggagacccgggugaagcuggaccacagggugaccaaggaagagaggggcccgucggcaucccuggagacucgggu


gaggcuggccccauuggaccuaaaggauaccgaggugaugaggguccuccagguccugagggccucagaggagccccaggaccug


uugguccuccuggagaccccggacugaugggugagagaggugaggauggaccaccaggaaacggcacggaagguuuccccggcuu


cccuggguauccaggcaacagaggcccuccugggcuaaauggcacaaaaggcuacccuggccucaagggggaugagggugaagug


ggagacccaggagaggauaacaacgacauuucaccccguggggucaaaggggcaaagggauaccgaggcccagaaggaccccagg


gaccuccaggacaugugggaccaccugggccagaugagugugagauccuggauaucaucaugaaaaugugcuccugcugugagug


cacauguggacccauugacauccucuucgugcuggacagcucggagagcauuggccuacagaacuuugagauugccaaggacuuc


aucaucaaggucauugaccgguugagcaaggaugagcuggucaaauuugagccagggcagucucacgcgggcgugguacaguaca


gccacaaccagaugcaagagcacguggacaugcggagccccaacguccgcaacgcccaggacuucaaagaagcugucaagaagcu


acaauggauggcugguggcacauucaccggagaagcgcugcaguacacccgggaccggcuacucccacccacacagaacaaccga


auugcccuggucauuacggauggacguucugacacucaacgggacacgacaccucucagugugcucuguggugcagacauucagg


ugaguuucugugggaaucaaggauguguuuggcuuuguggcgggcuccgaccagcucaaugucauuuccugccaaggcuuaucgc


aaggucguccagguaucucccuggugaaggagaacuaugcagagcuucucgaugacggcuuucugaagaacauaacagcccagau


cuguauagauaagaaguguccggauuauaccuguccaaucacauucuccuccccggcugacaucaccauccugcuagacagcuca


gccagugucggcagccacaacuucgaaaccaccaaggucuucgccaagcgccuagcugagcgauuccugucagcaggcagggcgg


auccuucccaggaugugcggguggccgugguacaguauaguggccaggggcagcaacagccaggucgggcggcucuucaguucuu


acagaauuacacagugcuggccagcucuguggacagcauggauuucaucaacgacgccacagacgucaacgaugcucugagcuac


gugacucguuucuaccgggaagccucgucaggugccaccaagaagagagugcuguuguuuucagacggcaacucucagggggcca


cagcagaggccauugagaaggcugugcaggaggcccagcgugcaggcauugagaucuuuguggugguggugggaccccaggugaa


cgagccccacauccgugugcuugucacuggcaagacugcagaguacgacguggccuuuggcgagcgccaccuauuccguguacca


aacuaccaggcccugcuacguggcguacucuaccagacagucuccaggaagguggcacugggcuagagggccacacacguggcug


gacacacauggcauggagacacauuucaacaggccuucccgcccuucccacugacaaaacaggaauaggaaaugugacccaacug


gucaacucaacugucuuaaagggaacgcugagaugcacacucuuugcuuuguguaauguccccuguggcucaccugagcuccuau


cuagaucccgcccuugguuuguacaucaugguggccaucuugcugaccccucccccaucugggacuggauccagccaucucgucu


uccuccucacugccccuaaccuauccguggugucuucacaccaucacugcaguuuccgucuguguucugucuuccaugcucaaca


ugaagcagaccuucucaugaguucagcuugcuggauuauggcuuuuaggaaauugaacacaggaggaguuccaaacacaaacuug


gaggagaccccuccucuucaucaggugcuugucagugaccuacaugcaucuuggucugguccuuaguggcuaguccuuccacucu


gaaagcaaaggugcuaucuaucuguaagggcucucucuacacacccagaggcuuagcuuggacaguucacacucaaguguccugu


cagaaucaauccagagcuuucucccucaaaauagugacuugucucccccugguccccaaaggcuccccuuuaguuaguuucuuca


uggcucccccacauuccccguaaucugauccaagccagcuaucucugcuaauaaagguuuccauuuuucaaaaaaaaaaaaaa


 










Tnc/Tenascin C
17
accccaugccccacccccaccuucgauguuuugaacauuucuaacaacugaag
252


AV230686

ccaguaaagucauauucuuuaaauuuccaggacauucauauuauucacauaau



X56304

cauggucauggugaugauggaaacugaggacuuuaaaagagauuuucccuucc





caaacguuucuggacaguaccugauuguauuuuuuuuguuuuguuuuguuuuu





uaauaaaagcacaguacuuuucc



 


Krt2-6a/Keratin
10
Sequence below.
253


complex 2, basic





gene 6a





(keratin 6a)





K02108










gucugcccugccguuucucuacuucccagccuucucaucuccaggaaccaugucuaccaaaaccaccaucaaaagucaaaccagc


caccguggcuacagugccagcucagccagagugcuuggacucaaccgcucgggcuucagcaguguguccgugugccgcucccggg


gcagcgguggcuccagugcaauguguggaggagcuggcuuuggcagcaggagccucuaugguguggggagcuccaagaggaucuc


caucggagggggcagcuguggcauuggaggaggcuauggcagccgauucggaggaagcuucggcauuggugguggagcugguagu


ggcuuuggcuucggugguggagcuggcuuuggugguggcuaugggggagcuggcuucccggugugcccacuuggaggcauccaag


aggucaccaucaaccagagccuccucacaccccugaaccugcaaauugaccccaccauccagcgggucaggacugaggagaggga


gcagaucaagacccucaauaacaaguuugccuccuucaucgacaaggugcgguucauggagcagcagaacaaggucauggacacc


aagugggcccugcugcaagagcaggacaccaagaccgugaggcagaacauggagcccauguuugagcaguacaucagcaaccucc


gcagacagcuggacagcaucauuggagagaggggucgcaugaacucagagcugaggaacaugcaggaacucguagaagaacuacg


gaacaaauaugaagaugaaaucaacaagcgcacagacgcagagaaugaauucgugacccugaagaaggauguagaugcugccuac


augaacaaaguugaacugcaagccaaggcagacagucuaacagaugauaucaacuucuugagagcucucuaugaagcagaacugu


cucagaugcaaacucacaucucagacacaucugugguccucuccauggucaacaaccguagccucguccuagacagcaucaucgc


ugaggucaaggcccaguuugaggucauagcucagagaagucgggcugaagcugagucauuguaccagacuaaauaugaggagcug


caggucacagcuggcagacauggggacgaccugcgcaacaccaagcaggagauugcugagaucaaccgcaugauccagaggcuga


gaucugagaucgaccacguuaagaagcagugugccaaccugcaagcugcuauugcugaugcugagcaacguggggagauggcccu


gaaggaugcaaggggcaagcuggaagggcuggaggaugcccugcagaaggccaaacaggacauggccaugcugcugaaggaguac


caugaacucaugaaugucaagcuggcccuugauguggaaauugccaccuacaggaagcugcuggaaggagaggagugcagguuga


auggugaagguguuggaccagucaacaucucuguggugcaguccaccguguccagcggcuauggcagugccgggggugccagcag


cagcuuaggcauggguggaggcagcagcuacuccuauagcagcagccauggccuuggagguggcuucagugcuggcaguggcaga


gccaucggagguggccucagcucuucugguggccucagcucuucuaccaucaaauacaccaccaccuccuccagcaagaagagcu


acaggcagugaauucugucaccaagagcuugucucuggucccagaugucauggcugcagcugaaccacaugcuuugguucccgga


agggaacgaaucccaaccucuggccuccccauggcucaguucuacauuuguguugcacgucagcaccuauacauguucuuuggug


acccagaccccaaaauguugcagaauguagaccuccaagacgaaaccccaaacccuacccagaauacccaccuaaauucugucau


gguucugacuuccuccagagucuguaaaauaaaaugcccccacaacaaac


 










Potassium
14
uuuuuuuuuuuuuuuuugauuuuaauuacaaacuuuauuuguccuccaguuca
254


channel,

caguuuauacgugguacaucccaccaugucagcuuccagaacggcuauucagg



subfamily K,

agauggguggagcuuucuuuguaaaggaacccgacauuuuaaaauuuugguua



member 2

gaaucuucauagguuuauaaaaguacucucugcaagcgaacuggauauauuua



AI849601

cauuuauagcuuaaauucaaauuuuggaaaauaggaaucuuuuuguguuuuua





aacauccuggguuuaugucuuaagacuuuacucugaaugccacaugaucacgu





aagcccaagccucccccagaagggaaaaaucaguuuugc



 


Skd3/Supressor
4
uuuuuuuuuuuuuuuuugggugccaugccacagcaaggggccuuuauuagaug
255


of K+ transport

uucagggcacagacagguggaugcuagaugguguagcacaccuucucagggug



defect 3

gaguggugccuggauguccaguuugcgggucuugcuguccuuaucaaugaucu



AI837887

ccagucgcaauguagguggacgcuucucagccuggggugagggcagcucacgg





cucuugaggaggugcuuguccgaauccuccacagugauacccagggugcaacc





cccugg



 


Clic4/Chloride
3
uuuuuuuuuuuuuuuucugacacaguaguaauccuuccagacuccuuacacaa
256


intracellular

uauuacaacucccccaguacauaaauguuccuauaccaugcacacagcaacau



channel 4

gggguccacugaugucgcaggcgacuuuucuaaugguggaacauagcaccuca



(mito-chondrial)

aguucugccaucuacacagugaagggacgugauggucggggcuccagagugac



AI845237

agcaaacugccucuugggugacacgcuuguggcgaagugccucc



 


Col18a1/
5
Sequence below.
257


Endostatin





(alpha 1 (XVIII)





collagen)





L22545










gagaauguugcugaggagguggggcugcugcagcuccuuggagacccccuaccugagaagaucucacaaaucgaugacccucacg


ucgggccggccuacaucuuuggaccagacuccaacaguggccagguggcccaguaucauuucccaaaacucuucuuccgggacuu


uucgcugcuguuucauguccggccagccacagaggcagcaggggugcuauuugccaucacagaugcugcccaggugguagucuca


cugggcgugaagcucucagagguccgagauggacagcaaaacaucucauugcucuacacggagccuggggccagccagacccaga


cgggagccagcuuccgccuaccugcauuuguugggcaguggacacacuucgcgcucagcgucgacggaggcucuguggcucucua


cguagacugugaagaauuccagagggugccauuugcucgggccucgcagggacuggagcuagagcguggcgcuggccucuuugug


ggucaggcuggaacagcagacccugacaaguuccaggggaugaucucagagcugaagguacgcaaaaccccccgggugagcccug


ugcacugucuggaugaagaagaugaugaugaagaccgggcaucuggagauuuuggaaguggcuuugaagaaagcagcaagucaca


caaggaggauacaucucuacuaccugggcucccucagccaccuccugucacuuccccaccccuggcuggaggcagcaccacagaa


gauccuagaacagaagaaacggaggaagacgccgcgguagauucuauaggagcugagacccuuccuggcacagguucaagcggug


caugggaugaggcuauccagaaccccggaaggggcuugauaaagggagguaugaaaggacaaaagggagaaccaggugcccaggg


cccaccuggcccagcuggcccccaggguccugccgguccagugguccagagccccaacucacaaccugucccuggagcacaagga


cccccgggaccucaggggccaccagggaaggauggcacuccaggaagggauggugaaccgggugacccuggugaagaugggagac


cgggugacacuggaccucaaggcuuuccagggaccccaggagaugugggcccuaagggcgagaagggagauccugguauugggcc


ccgaggaccuccagggccuccagggccaccaggacccuccuucagacaagacaagcugaccuucauugacauggagggauccggu


uucagcggagacauagagagccuuagaggcccacgaggcuucccuggccccccggggcccccuggugucccaggacuuccuggug


agccaggacgcuuugggaucaaugguuccuaugcaccaggaccugcaggccuuccugguguaccugggaaggaaggaccccccgg


uuuuccaggucccccgggaccuccagguccuccaggcaaagagggcccaccaggaguggccggccagaaaggcaguguuggugau


gugggcaucccaggacccaaggggagcaaaggagaccuugggcccaucgguaugccuggcaagucuggcuuggcuggauccccug


ggccaguuggacccccaggaccuccagggccuccagggccaccaggaccaggauuugcugcuggauucgaugauauggaaggcuc


uggaauaccccucuggacaacagcccgaagcucugaugggcugcagggaccucccgggucgccgggacucaagggggauccugga


guggcaggccuaccuggagccaagggagaaguuggagcagauggagcccagggcaucccuggucccccaggaagagaaggugcag


cuggaucuccggggccaaaaggagagaaggggaugccgggagaaaagggaaacccaggaaaagauggagugggccggccgggccu


cccugggccuccaggaccuccagggcuggugaucuaugugucaagugaggauaaagcaauagugagcacgccaggaccugagggc


aagccaggguacgcaggcuuuccuggaccugcuggaccgaagggugaccuggguuccaaaggcgagcagggucuuccgggguuua


agggugagaagggagagccaggcacuaucuuuaguccugauggcagacgucugggccauccccagaagggagccaagggagagcc


aggcuuucgaggacccccggguccuuauggacgaccugggcacaagggugaaauuggcuucccuggacggccgggucgaccugga


acgaauggcuuaaagggagagaagggagagccuggagaugccagccuuggguucagcaugaggggauugccuggccccccugggc


cuccaggacccccagguccuccugggaugcccaucuaugacagcaaugcauuuguggagucuggccgaccuggacuaccaggaca


gcagggugugcaggggccuucaggaccaaagggugacaaaggagagguggggccaccugggccaccagggcaauuccccauugac


cucuuccaccuggaagcggaaaugaagggggacaagggagaccgaggggaugcuggacagaaaggagagaggggagaaccugggg


cuccuggugguggauucuucagcucaaguguaccuggcccacccggcccaccuggauacccuggaauuccggguccaaagggaga


gagcauccgggggccaccuggcccuccuggcccgcagggaccuccuggcauuggcuaugagggucgccagggucccccaggaccu


ccaggaccuccaggaccucccuccuucccuggcccucacagacagacugucaguguuccugguccuccgggcccaccugguccuc


caggucccccaggagccaugggugccucugcugggcaggugaggaucugggccacauaccagaccaugcuggacaagauccggga


ggugccggagggcuggcucaucuuuguggccgagagggaagagcucuauguacgcguuagaaauggcuuccggaaggugcugcug


gaggcccggacagcccuccugagaggcacgggcaaugagguggcugcuuuccagcccccauugguccagcuucaugagggcaguc


cauacacccggagggaguacuccuauuccacggcacgacccuggcgagcagaugacauccuggccaacccaccgcgccugccaga


ccgccagccuuacccuggaguuccacaucaccacaguuccuaugugcaccugccgccagcccgccccacccucucacuugcucau


acucaucaggacuuucagccagugcuccaccugguggcacugaacaccccccugucuggaggcaugcgugguauccguggagcag


auuuccagugcuuccagcaagcccgagccguggggcugucgggcaccuuccgggcuuuccuguccucuaggcugcaggaucucua


uagcaucgugcgccgugcugaccgggggucugugcccaucgucaaccugaaggacgaggugcuaucucccagcugggacucccug


uuuucuggcucccagggucaagugcaacccggggcccgcaucuuuucuuuugacggcagagauguccugagacacccagccuggc


cgcagaagagcguauggcacggcucggaccccagugggcggaggcugauggagaguuacugugagacauggcgaacugaaacuac


uggggcuacaggucaggccuccucccugcugucaggcaggcuccuggaacagaaagcugcgagcugccacaacagcuacaucguc


cugugcauugagaauagcuucaugaccucuuucuccaaauaggccucugccagcuaggguggcagacagaggccaugcagaacuu


ugacacagcgcagggagcauucagucagcacccagggcucuggcugggauacaacuccuguauaguucccauuuuuauguaaucc


ucaagaaauaaaaggaagccaaagaguaaaaaaaaa



















TABLE 5





Gene
Fold




Name/Protein
Decr
Sequence
SEQ ID No.















Growth Factors, Receptors and Downstream genes










GNA-14
32
Sequence below.
258


Mouse G





protein alpha





subunit (GNA-14)





M80631










aacugccuucgagaagcguuagccuagagauccgagccucuucuccauaccauaguugguucaggugguuuccucuucaa


accuugcgucugcggauaauccgcgcggccgggcguuaagcuccaggucccugucgcuccgucgagguggcaagccaugg


ccggcugcugcuguuugucugcggaggagaaagagucucagcgcaucagcgcggagaucgagcggcacguucgccgcgac


aagaaggacgcgcgccgggagcucaagcugcuguugcugggaaccggugagagugggaaaagcaccuuuaucaagcagau


gaggauaauccaugggucuggcuacagugaugaagauagaaagggcuucacgaagcugguuuaccaaaacauauucacgg


ccaugcaagccaugaucagagcaauggauacccugaggauacaauacaugugugagcagaauaaggaaaaugcccagauc


aucagggaaguggaaguagacaaggucacugcacucucuagagaccagguggcagccaucaagcagcuguggcuggaucc


cggaauccaggaguguuacgacaggaggagggaguaccagcugucagacucugccaaauauuaccugacggacauugagc


guaucgccaugcccucuuucgugccaacacaacaggaugugcuucguguuagagugcccaccacuggcaucauagaauau


ccauucgaccuggaaaacaucaucuuccgaaugguggauguugguggccagcgaucugaacgacggaaauggauucacug


cuuugagagugucaccuccaucauuuucuugguugcucugagugaauaugaccagguucuggcugagugugacaaugaga


accgcauggaggagagcaaagcccuguuuagaaccaucaucaccuaccccugguuucugaacuccuccgugauucuguuc


uuaaacaagaaggaucuucuagaggagaaaaucauguacucucaucuaauuagcuacuucccagaguacacaggaccaaa


gcaagaugucaaagcggccagggacuuuauccugaagcuguaucaagaccagaauccugacaaagagaagguuaucuauu


cucacuucacuugugcuacagacaccgagaauauccgcuuuguguuugcugcugucaaagacacaauccuacagcuaaac


cuacgggaguucaacuugguguaaauggagggccuacuccuccgagacagagggugaucugagcccuuccugccugaucu


acaagugcuucuggaccaggaccuaaggacauuauguagcccacaggacagagauggguagugcaaugugaaaaauacuu


caccaacccuuuuaagugucuuuaauucuucacugucuaacucuuuuucucgccuuuugguugaacgauuagguaucauu


uuugagugguucccccucuccuauuuuuuuaaacuaguguucaacaguuauuaaaaaaucaugc


 










Ly6/Lymphocyte
12
gaauucccugcaaccuugucugagaggaagcaaggacuggugugagga
259


antigen 6 complex

gggagcugugagguuuuaucugugcagcccuucucugaggauggacac



X04653

uucucacacuacaaaguccuguuugcugauucuucuuguggcccuacu





gugugcagaaagagcucagggacuggaguguuaccagugcuauggagu





cccauuugagacuucuugcccaucaauuaccugccccuacccugaugg





agucuguguuacucaggaggcagcaguuauuguggguucucaaacaag





gaaaguaaagaacaaucuuugcuuacccaucugcccuccuaauauuga





aaguauggagauccuggguacuaaggucaaugugaagacuuccuguug





ccaggaagaccucugcaaugcagcaguucccaauggaggcagcaccug





gaccauggcaggggugcuucuguucagccugagcucaguccuccugca





gaccuugcucugaugguccucccaaugaccuccacccuuguccuuuua





uccucaugugcaacaauucuuccuggagcccucuagugaugaauuaug





aguuauagaagcuccaaggugggaguagugugugaaauaccauguuuu





gccuuuauagcccugcuggguagguaggugcucuaauccucucuaggg





cuuucaagucuguacuuccuagaaugucauuuuguuguggauugcugc





ucaugacccuggaggcacacagccagcacagugaagaggcagaauucc





aagguauuaugcuaucaccauccacacauaaguaucugggguccugca





auguucccacauguauccugaaugucccccuguugaguccaauaaacc





cuuuguucuccc



 


Bmp4/Bone
11
Sequence below.
260


morphogenetic





protein 4





L47480










ggaagaaagagagggagggaaaagagaaggaagaguagaugugagaggguggugcugagggugggaaggcaagagcgcga


ggccuggcccggaagcuaggugaguucggcauccgagcugagagaccccagccuaagacgccugcgcugcaacccagccu


gaguaucuggucuccgucccugaugggauucucgucuaaaccgucuuggagccugcagcgauccagucucuggcccucga


ccagguucauugcagcuuucuagagguccccagaagcagcugcuggcgagcccgcuucugcaggaaccaauggugagcag


ggcaaccuggagaggggcgcuauucugaggauucgaggugcacccguaguagaagcuggggauggggcucaggcuguaac


cgaggcaaaaguuggccuauuccuccuuccuucuccaacaguguuggaggugggaugauggaggcuaaaaggcaccucca


uauauguuacugcgucuaucaaccuacuuuagggaggugcgggccaggagaggcggaaggagagaaggccuuggaagaga


ggucauugggaagaacugugggguuugguggguuugcuuccacuuagacuauaagagugggagaggagggagucaacucu


aaguuucaacaccagugggggacugaggacugcuucauuaggagagagaaccuagccagagcuagcuuugcaaaagaggc


uguaguccugcuuugcucuaaagcgcgacccgggauagagaggcuuccuugagcggggugucaccuaaucuuguccccaa


cgcacccccucccagccccugagagcuagcgaacuguagguacacaacucgcucccaucuccaggagcuauuuucuuaga


caugggcacccaugauucugccuucugguacucuccccucccugggaaagggguguaagguuccgacggaaccguggcca


ggaugccgaaaggcuaccugugcgggucuucugccaugcugugucugugcggacaugccagcagggcuaaugaggagcuu


gcgauacuccaaaggguucgggaauugcgggguccuuacacgcaguggaguugggccccuuuuacucagaagguuuccgc


cacggcuuugguugauaguuuuuuuaguauccugguuuaugaacugaagguuuugugagauguugaaucacuagcagggu


cauauuuggcaaaccgaggcuacuauuaaauuuugguuuuagaagaagauucuggggagaaagugaaggguaacugccuc


caggagcuguaucaaccccauuaagaaaaaaaaaaauaccaggagaugaaaauuuacuuugaucuguauuuuuuaauuaa


aaaaaaucagggaagaaaggagugauuagaaagggauccugagcgucggcgguuccacggugcccucgcuccgcgugcgc


cagucgcuagcauaucgccaucucuuucccccuuaaaagcaaauaaacaaaucaacaauaagcccuuugcccuuuccagc


gcuuucccaguuauucccagcggcgacgcgugucggggaauagagaaaucgucucagaaagcugcgcugaugguggugag


agcggacugucgcucagggggcgcccgcggucucugcacccagggcagcagugugggauggcgcugggcagccaccgccg


ccaggaaggacgugacucuccauccuuuacacuucuuucucaaagguuucccgaaagugccccccgccucgaaaacuggg


gccggugcggggggggggagagguuagguugaaaaccagcuggacacgucgaguuccuaagugaggcaaagaggcggggu


ggagcgggcucuggagcgggggaguccugggacucgguccucggauggaccccgugcaaagaccuguuggaacaagaguu


cgcgcuuccgagguuagaacaggccaggcaucuuaggauagucaggucacccccccccccaaccccacccgaguuguguu


ggugaauuucuuggaggaaucuuagccgcgauucuguagcuggugcaaaaggaggaaaggggugggggaaggaaguggcn


gngcggggguggcgguggggguggaggugguuuaaaaaguaagccaagccagagggagaggucgagugcaggccgaaagc


uguucucggguuuguagacgcuugggaucgcgcuuggggucuccuuucgugccggguaggaguuguaaagccuuugcaac


ucugagaucguaaaaaaaaugugaugcgcucuuucuuuggcgacgccuguuuuggaaucuguccggaguuagaagcucag


acguccaccccccaccccccgcccacccccucugccuugaauggcaccgccgaccgguuucugaaggaucugcuuggcug


gagcggacgcugagguuggcagacacgguguggggacucuggcggggcuacuagacaguacuucagaagccgcuccuucu


aacuuucccacaccgcucaaaccccgacacccccgcggcggacugaguuggcgacggggucagagucuucuggcugaaag


uuagauccgcuaggggucggcugccugucgcuagaagcauuauuuggccucucggagacccguguggaggaagugcugga


gugugcgaguguguuugcgugugugugugugugugugugugugugugugugugugugugugugcgcgcgcccuuggaggg


ucccuaugcgcuuuccuuuucauggaacgcugucgugaggcucccugauccucaggcuucagauaacccguccccgaacc


uggccagaugcauugcacugcgcgccgcagguagagacgugccccacguccccugcgugcagcgacuacgaccgagagcc


gcgccaguguggugucccgccgagaguuccucagagcaggcggggacaacucccagacggcuggggcuccagcugcgggc


gcggagguuggccucgcucgcaggggcuggacccagccggggugggaggauggaggaggggcgggcgggcucuucgguga


guggggcggggccucuggguccacgugacuccuaggggcuggaagaaaaacagagccugucugcuccagagucucauuau


aucaaauaucauuuuaggagccauuccguagugccauucggagcgacgcacugccgcagcuucucugagccuuuccagca


aguuuguucaagauuggcucccaagaaucauggacuguuauuaugccuuguuuucugucagugaguagacaccucuucuu


ucccuucuugggauuucacucuguccucccaucccugaccacugucugucccucccgucggacuuccauuucagugcccc


gcgcccuacucucaggcagcgcuaugguucucuuucuggucccugcaaggccagacacucgaaauguacgggcuccuuuu


aaagcgcucccacuguuuucucugauccgcugcguugcaagaaagagggagcgcgagggaccaaauagaugaaagguccu


cagguuggggcugucccuugaagggcuaaccacucccuuaccagucccgauauauccacuagccugggaaggccaguucc


uugccucauaaaaaaaaaaaaaaaaacaaaaaacaaacagucguuugggaacaagacucuuuagugagcauuuucaacgc


agcgaccacaaugaaauaaaucacaaagucacuggggcagccccuugacuccuuuucccagucacuggaccuugcugccc


gguccaagcccugccggcacagcucuguucuccccuccuccuguucuuaaccagcuggaaguuguggaaauugggcugga


gggcggaggaagggcggggguggggggguggagaaggugggggggggggaggcugaagguccgaagugaagagcgauggc


auuuuaauucucccuccnccuccccccuuuaccuccucaauguuaacuguuuauccuugaagaagccacgcugagaucau


ggcucagauagccguugggacaggauggaggcuaucunauuugggguuauuugaguguaaacaaguuagaccaaguaauu


acagggcgauucuuacuuucgggccgugcauggcugcagcugguguguguguguguagggugugagggagaaaacacaaa


cuugaucuuucggaccuguuuuacaucuugaccgucgguugcuaccccuauaugcauaugcagagacaucucuauuucuc


gcuauugaucgguguuuauuuauucuuuaaccuuccaccccaacccccuccccagagacaccaugauuccugguaaccga


augcugauggucguuuuauuaugccaaguccugcuaggaggcgcgagccaugcuaguuugauaccugagaccgggaagaa


aaaagucgccgagauucagggccacgcgggaggacgccgcucagggcagagccaugagcuccugcgggacuucgaggcga


cacuucuacagauguuugggcugcgccgccguccgcagccuagcaagagcgccgucauuccggauuacaugagggaucuu


uaccggcuccagucuggggaggaggaggaggaagagcagagccagggaaccgggcuugaguacccggagcgucccgccag


ccgagccaacacugugaggaguuuccaucacgaaggucaguuucugcucuuaguccuggcgguguagggugggguagagc


rccggggcagaggguggggggugggcagcuggcagggcaagcugaagggguuguggaagcccccggggaagaagaguuca


uguuacaucaaagcuccgaguccuggagacuguggaacagggccucuuaccuucaacuuuccagagcugccucugagggu


acuuucuggagaccaaguagugguggugaugggggaggggguuacuuugggagaagcggacugacaccacucagacuncu


gcuaccncccagnggguguucuuuagcuauaccaaagncagggauucugcccguuuuguuccaaagcaccuacugaauuu


aauauuacancuguguguuugucagguuuaucaauaggggccuuguaauacgaucugaauguuuccuagcggauguuucu


uuuuccaaaguaaaucugaguuauuaauccuccagcaucauuacuguguuggaauuuauuuucccuucuguaacaugauc


aacaaggcgugcucuguguuucuaggaucgcuggggaauguuugguaacauacucaaaaguggagagggagagagggugg


ccccucuuuuucuuuacaaccacuuguaaagaaaacuguacacaaagccaagaggggcuuuaaaaggggaguccaagggu


gguggaguaaaagaguugacacauggaaauuauuaggcauauaaaggagguugggagauacuuucugucuuugguguuug


acaaaugugagcuaaguuuugcugguuugcuagcugcuccacaacucugcuccuucaaauuaaaaggcacaguaauuucc


uccccuuagguuucuacuauauaagcagaauucaaccaauucugcuauuuuuuguuuuuguuucuuguuuuuguuuuguu


ugguuuuuuuuuuuuuuuuuuuuuuuuugucucagaaaagcucaugggccuuuucuuuuccccuuucaacugugccuaga


acaucuggagaacaucccagggaccagugagagcucugcuuuucguuuccucuucaaccucagcagcaucccagaaaaug


aggugaucuccucggcagagcuccggcucuuucgggagcagguggaccagggcccugacugggaacagggcuuccaccgu


auaaacauuuaugagguuaugaagcccccagcagaaaugguuccuggacaccucaucacacgacuacuggacaccagacu


aguccaucacaaugugacacggugggaaacuuucgaugugagcccugcaguccuucgcuggacccgggaaaagcaaccca


auuaugggcuggccauugaggugacucaccuccaccagacacggacccaccagggccagcaugucagaaucagccgaucg


uuaccucaagggaguggagauugggcccaacuccgcccccuccuggucacuuuuggccaugauggccggggccauaccuu


gacccgcaggagggccaaacguagucccaagcaucacccacagcgguccaggaagaagaauaagaacugccgucgccauu


cacuauacguggacuucagugacgugggcuggaaugauuggauuguggccccacccggcuaccaggccuucuacugccau


ggggacugucccuuuccacuggcugaucaccucaacucaaccaaccaugccauugugcagacccuagucaacucuguuaa


uucuaguaucccuaaggccuguuguguccccacugaacugagugccauuuccauguuguaccuggaugaguaugacaagg


ugguguugaaaaauuaucaggagauggugguagagggguguggaugccgcugagaucagacguccggagggcggacacac


acacacacacacacacacacacacacacacacacacacaguucccauucaaccaccuacacauaccacacaaacugcuuc


ccuauagcuggacuuuuaucuuaaaaaaaaaaaaaagaaagaaagaaagaaagaaagaaaaaaaaugaaagacagaaaag


aaaaaaaaaacccuaaacaacucaccuugaccuuauuuaugacuuuacgugcaaauguuuugaccauauugaucauauuu


ugacaaauauauuuauaacuacauauuaaaagaaaauaaaaugag


 










Il1r2/Interleukin
11
gaaucccacuuacaugcgagcaucucuauauacauccucaaucuaucc
261


1 receptor, type

ccucgaauccacggacuuaucagucaaucaauacuacagucaaagaau



II

uuuuuucuacguuauccuggagcauugcgcuggcaccucuuuuucuaa



AV223216

ucaucuugguuguggggccaauauggaugcgcagacgguguaaacgca



X59769

gggcuggaaagacauauggacugaccaagcuacggacugacaaccagg





acuucccuuccagcccaaacuaaauaaaggaaaugaa



 


Wnt3a/wingless-
4
Sequence below.
262


related MMTV





integration site





3A





X56842










gaauucaugucuuacggucaaggcagagggcccagcgccacugcagccgcgccaccucccagggccgggccagcccaggc


guccgcgcucucgggguggacuccccccgcugcgcgcucaagccggcgauggcuccucucggauaccucuuagugcucug


cagccugaagcaggcucugggcagcuacccgaucuggugguccuuggcugugggaccccaguacuccucucugagcacuc


agcccauucucugugccagcaucccaggccugguaccgaagcagcugcgcuucugcaggaacuacguggagaucaugccc


agcguggcugagggugucaaagcgggcauccaggagugccagcaccaguuccgaggccggcguuggaacugcaccaccgu


cagcaacagccuggccaucuuuggcccuguucuggacaaagccacccgggagucagccuuuguccaugccaucgccuccg


cuggaguagcuuucgcagugacacgcuccugugcagagggaucagcugcuaucugugggugcagcagccgccuccagggc


uccccaggcgagggcuggaaguggggcggcuguagugaggacauugaauuuggaggaauggucucucgggaguuugccga


ugccagggagaaccggccggaugcccgcucugccaugaaccgucacaacaaugaggcugggcgccaggccaucgccaguc


acaugcaccucaagugcaaaugccacgggcuaucuggcagcugugaagugaagaccugcugguggucgcagccggacuuc


cgcaccaucggggauuuccucaaggacaaguaugacagugccucggagauggugguagagaaacaccgagagucucgugg


cuggguggagacccugaggccacguuacacguacuucaaggugccgacagaacgcgaccuggucuacuacgaggccucac


ccaacuucugcgaaccuaaccccgaaaccggcuccuucgggacgcgugaccgcaccugcaaugugagcucgcauggcaua


gaugggugcgaccuguugugcugcgggcgcgggcauaacgcgcgcacugagcgacggagggagaaaugccacuguguuuu


ccauuggugcugcuacgucagcugccaggagugcacacgugucuaugacgugcacaccugcaaguaggagagcuccuaac


acgggagcaggguucauuccgaggggcaagguuccuaccugggggcgggguuccuacuuggaggggucucuuacuugggg


acucgguucuuacuugagggcggagauccuaccugugagggucucauaccuaaggacccgguuucugccuucagccuggg


cuccuauuugggaucuggguuccuuuuuaggggagaagcuccugucugggauacggguuucugcccgaggguggggcucc


acuuggggauggaauuccaauuugggccggaaguccuaccucaauggcuuggacuccucucuugacccgacagggcucaa


auggagacagguaagcuacucccucaacuaggugggguucgugcggaugggugggaggggagagauuagggucccuccuc


ccagaggcacugcucuaucuagauacaugagagggugcuucagggugggcccuauuugggcuugaggaucccgugggggc


ggggcuucaccccgacuggguggaacuuuuggagacccccuuccacuggggcaaggcuucacugaagacucaugggaugg


agcuccacggaaggaggaguuccugagcgagccugggcucugagcaggccauccagcucccaucuggccccuuuccaguc


cugguguaagguucaaccugcaagccucaucugcgcagagcaggaucuccuggcagaaugaggcauggagaagaacucag


gggugauaccaagaccuaacaaaccccgugccuggguaccucuuuuaaagcucugcaccccuucuucaagggcuuuccua


gucuccuuggcagagcuuuccugaggaagauuugcagucccccagaguucaagugaacacccauagaacagaacagacuc


uauccugaguagagaggguucucuaggaaucucuauggggacugcuaggaaggauccugggcaugacagccucguaugau


agccugcauccgcucugacacuuaauacucagaucucccgggaaacccagcucauccgguccgugauguccaugccccaa


augccucagagauguugccucacuuugaguuguaugaacuucggagacauggggacacagucaagccgcagagccagggu


uguuucaggacccaucugauuccccagagccugcuguugaggcaauggucaccagauccguuggccaccacccugucccg


agcuucucuagugucugucuggccuggaagugaggugcuacauacagcccaucugccacaagagcuuccugauugguacc


acugugaaccgucccucccccuccagacaggggaggggauguggccauacaggagugugcccggagagcgcggaaagagg


aagagaggcugcacacgcguggugacugacugucuucugccuggaacuuugcguucgcgcuuguaacuuuauuuucaaug


cugcuauauccacccaccacuggauuuagacaaaagugauuuucuuuuuuuuuuuuucuuuucuuucuaugaaagaaauu


auuuuaguuuauaguauguuuguuucaaauaauggggaaaguaaaaagagagaaaaaaaaaaaaaaaaaaaaaaaaaaaa


aaaaaaaaaa


 










Il12rb2/
3
Sequence below.
263


Interleukin 12





receptor, beta 2





U64199










cgcaccggagguccacacugccgcguggacuccagcgauggcgcugcgcuaggcuagcgggugccaggaucccucucugc


guccugugcgcgggaagagcucuggagaaccagaguugcauucuggaguugaagacucauggcacagacuguuagagaau


gcucauuggcacuucuuuuuuuguucauguggcugcugauuaaagcaaauauagaugugugcaagcuuggcacugugacc


guccagccugccccugugauuccucuugggucagcugccaauauuuccugcuccuugaaucccaagcaaggcuguucaca


uuaucccaguucuaacgaauuaauccucuuaaaguuugucaaugauguccuuguugaaaaucuccauggcaagaaagucc


augaccacacuggucacuccuccacuuuucaagucaccaaccugucccuugguaugaccuuguuugucugcaagcuaaac


uguagcaacucucaaaagaagccaccagucccaguaugugggguggagaucucaguugguguugcuccagagccaccuca


aaacauaucauguguccaggaaggagaaaauggaacuguggccuguuccuggaacucuggaaaaguuacuuaucugaaaa


ccaauuacacuuuacaguuaaguggaccaaacaaucugaccugucagaaacaauguuuuucugacaaucgucagaauugc


aaucgccuggaucuugggaucaaucuaagcccugauuuagcugaauccagguucauaguccguguuacugccaucaacga


ucuuggaaauucuucuucacuuccgcauacguucacguucuuggacauagugaucccucuuccuccgugggacaucagaa


ucaacuuucuaaaugcuucugggagcagagguacacugcagugggaagaugaggggcaagugguacucaaucaacucaga


uaucagccucuuaacagcacguccuggaacauggucaaugcuacaaaugccaaaggaaaauaugaccugcgagaucugag


accguuuacagaauaugaauuucaaaucuccucuaagcuacaucucucuggaggaaguuggaguaauuggagugagucac


ugagaacacgaacaccagaggaagagccuguugggauauuagacaucugguacaugaaacaagacaugacuaugacagac


agcagaucucucuuuucuggaagagucugaauccaucagaggcaagggggaagauccuccacuaucaggugacguuacaa


gaggugacaaagaaaacaacacugcagaauacuacaagacacaccuccuggaccagggucaucccccgaacuggggcuug


gacggcaucagugucugcagccaacucaaaaggcgcuucugcacccacucacauuaacauaguggaccuauguggcacug


gguugcuggcuccucaccaggucucugcaaagucggagaacauggacaacauucuagugaccuggcagccuccuaagaaa


gcugauucugcuguucgggaguacauaguggaauggagagcucuccaaccagggagcaucacgaaguuucccccacacug


gcugcggauccccccggacaacaugucugcucugauuucagagaacauaaagcccuauaucuguuaugaaaucagggugc


augcacugucagagagccaaggagggugcagcuccauccggggugacuccaagcacaaagcaccagugaguggcccucac


auuacugccaucacagagaaaaaggaacgccuuuucauuuccuggacccacauuccauucccggagcaaaggggcugcau


ccuccauuacagaauauacuggaaagaacgagacucgacagcacaaccugagcucugcgaaauucaguaccgacgcucuc


aaaacucacauccaauaagcagccuacagcccagggugacauauguccuauggaugacagcugugacagcugcuggugaa


aguccccaaggaaaugaaagggaauuuuguccacagggcaaagccaacuggaaagcauucgugauaucaagcauuugcau


cgcuaucaucacggugggcacguucucaauucguuacuuccggcaaaaggcauuuacucuccugucuacucucaaaccuc


aaugguauagcagaaccauuccagauccagcaaacagcacuuggguaaagaaguaucccauucuggaggagaagauccag


cuaccuacggauaaucuccugauggcauggcccacuccugaagagccugagccccugaucauccaugaaguccucuacca


caugaucccaguugucagacaaccauauuacuucaaaagaggccaaggauuccaaggcuacucuaccuccaagcaagaug


caauguauauugccaauccacaagcuacaggaacucucacagcugagaccagacaacuagugaaccuauacaaggugcua


gaaagcagagacccugacucaaaacuggccaaccugaccagccccuugacagucaccccagugaacuaccuuccuagcca


ugaaggcuauuuacccuccaacauagaagaucugucaccacaugaggcugacccaacugauucuuuugaccuggagcauc


aacauauuucucuuuccauuuuugcaucaaguucucuccgcccacucaucuucgguggugagcggcugacucuagaucgg


uuaaagaugggcuaugacucccucaugaguaaugaggcuugauacuagaaagccaacguaccucauuuuaucugcccagu


uccuacuccaaaggucugugacagugaagacaagccagcugucucuggauaaaguuagcuucaccauagguacuuaaguc


uuauggauaagguggcaauacaccaacacugauaucauauagaaaggaccccaagauagucaugcuc


 










Wnt10a/Wingless-
3
Sequence below.
264


related MMTV





integration site





10a





U61969










ggcacgaguucacccucugcaugcguuccccuccccccucuccagcaaacacggcgcgccaguccaaagcggacucagug


gccucggggacgggagcaugccaccuccuguggugacgucacuugggguagaacccuuagacacuacauggggggggggg


guacagaacucccgagccaggacagucacucacucuucaggcgguggggcugggccagacaguaccgcccccaccgcgcc


cgccucgcacacccucggaagcgcaggcucgcagcgcggcgcuggggugggggguugcgccccagaacuucggccuccag


uccccagcccgcugcaccuccuuacccucuagaggcccccucccccuuacccucuagaggcaccaggaguugucgcaagg


ggcccuugggaaauucccuggaccccugugccaggaggugcccgguucgcccgcuccccauccacccccccgagggcggu


gcccgggggcgcugccccauggagcggggaggcgggcgccgucugcugcgggagcugugaccugaguaggagcugugugu


cgcagccgccccaccccugccgaucaugcgccggcgacccugguucgccagucccacugggcugugagccccccacuccu


ggccugucacggcccgcgcgccaugggcagcgcccacccucgccccuggcugcggcucccacaagggccccagccgcggc


cugaguucugggcgcuccuguucuuccuacugcugcuggcugccgcugugcccaggucagcacccaacgacauccugggc


cuccgccuacccccagagcccgugcucaacgccaacacagugugccugacauugcccggccugagccggcggcagaugga


ggugugugugcgucacccugacguggccgccucugcuauccagggcauccagaucgccauccaugagugccagcaucagu


uccgggaccagcgcuggaacugcuccagccuggagacucggaacaaaguccccuacgagagccccaucuucagccgaggu


uuucgagagagugcuuucgccuacgccauagcagcugccgggguggugcacgcaguguccaacgcgugcgcucuggguaa


acugaaggcuugcgguugcgacgccuccagacguggggacgaagaagcuuuccgcuggaagcugcaccgcuugcagcugg


acgcgcugcagcgcggaaagggcuugagccacggggucccugaacacccggccauacuuccugccagcccaggucugcag


gacuccugggagugggguggcugcaguccggaugugggcuucggagaacgcuucucuaaggacuuucuggacucccgaga


gccucacagagacauccaugcucgaaugagacuccacaacaaccgugugggccggcaggcggugauggagaacaugcggc


guaagugcaaaugccacggcaccucaggcagcugccagcucaagaccugcuggcaggugacgccugaguuccgcacagua


ggggcgcugcugcgcaaccgcuuccaccgcgccacgcucauccggccgcacaaccgcaacgguggccagcuggagcccgg


ccccgcgggagcacccucgccagcaccgggcacuccagggcugcgccgcagggccagccacuccgaccuggucuacuuug


agaaaucucccgacuucugugagcgcgagccgcgccuggacucggcaggcacugugggccgccugugcaauaagagcagc


acgggucccgauggcugcggcagcaugugcuguggccgcggccacaacauucugcgccagacgcgcagcgagcgcugcca


cugccgguuccacuggugcugcuucguggucugcgaagaaugccgcaucaccgagugggucagcgucugcaagugagcag


acccaagcuccucugggucucaagaaugguuguccucuuggugccuggcuucugccgcuagcggaucugagccaggcagc


aagcagcagccuuggcuccugagagaggugguuggcucuuacagccccgagggucuacaauacaccagacaguccagauc


ugauugacauuccuccgcucaccucuguagguuccccucuuucuguuccuagcucagacagcugggggugauaguggaga


cuguuccacacccuaggacagguacaccaaagcagcccagccuggcaugccuaccuccugucaucucuucuucccuuccc


caggagugauaggcaaugcacugaagcugaugggcaccggggaagaaaacuaaaaggcagaaauggccgucaucgggcug


aagugacucuaagggcuccagaccucugcuccugucuuucacuuaacagauauuuauuuuugcgcucucuuugagacacu


cucugggaaaaagaagcuccggagucuacaggcugauuaagggacauggacaauaaaccaguaaacacacaaaaaaaaaa


aaaaaaaa


 










Ifngr2/Inter-
3
Sequence below.
265


feron-gamma





receptor precursor





M28233










gaauuccgggccgcuugcacuuggcgacuagucugcggcggacgugacgccaaggccacgggcagcgcggguccccuguc


agaggugucccucgcgcaggaaugggcccgcaggcggcagcuggcaggaugauucugcuggugguccugaugcugucugc


gaaggucgggaguggagcuuugacgagcaccgaggauccugagccucccucggugccuguaccgacgaauguucuaauua


agucuuauaacuugaacccugucguaugcugggaauaccagaacaugucacagacuccuauuuuuacuguacagguaaag


guguauucggguuccuggacugauuccugcaccaacauuucugaucauuguuguaauaucuaugaacaaauuauguaucc


ugauguaucugccugggccagaguuaaagcuaagguuggacaaaaagaaucugacuaugcacggucaaaagaguuccuua


ugugccuaaagggaaaggucgggcccccuggccuggagaucaggaggaagaaggaagaacagcucuccguccucguauuu


cacccugaagucguugugaauggagagagccagggaaccauguuuggugacgggagcaccuguuacacauucgacuauac


uguguauguggagcauaaccggaguggggagauccuacauacgaaacauacggucgaaaaagaagaguguaaugagacuc


ugugugaguuaaacaucucaguauccacacuggauuccagauauuguauuucaguagacggaaucucaucuuucuggcaa


guuagaacagaaaaaucgaaagacgucuguaucccuccuuuccaugaugacagaaaggauucaauuuggauucugguggu


ugcuccucuuaccgucuuuacaguaguuauccugguauuugcguauugguauacuaagaagaauucauucaagagaaaaa


gcauaauguuaccuaaguccuugcucucugugguaaaaagugccacguuagagacaaaaccugaaucgaaguauucacuu


gucacaccgcaccagccagcuguccuagagagugagacggugaucugugaagagccccuguccacagugacagcuccaga


cagccccgaagcagcagaacaggaagaacuuucaaaagaaacaaaggcucuggaggcuggaggaagcacgucugccauga


ccccagacagcccuccaacuccgacacaaagacgcagcuuuucccuguuaaguaguaaccagucaggcccuuguagccuc


accgccuaucacucccgaaacggcucugacaguggccucgugggaucgggcagcuccauaucggacuuggaaucucuccc


aaaacaacaacucagaaacaaagauggcagagcacgacccuccacccgugagaaaggcccccauggccuccgguuaugac


aaaccgcacauguugguggacgugcuuguggauguuggggggaaggagucucucaugggguauagacucacaggagaggc


ccaggagcuguccuaaggucucccgaggccugcuggugguaaagaaacugaccuuuuaggcaguuuuucugcauugauuu


caugaaagaagcuauacauuagcuaauacuaaccacauagaauaucagacuuagauacgugaauaaggauccugugggca


cugcuggguccacucugcaaaugccaagacuaucaaaggaacguauugucgcuucuggcuccuucccaggugggcuagca


ucugugaguuugccucggcuagccuugcuuccuacagccgccacugcuccuccacccugaucaucucacaggacagggug


gaccggguuuuuuuuuuuuuuucacacaccuuuguauauguaaguucauguauauaauauguuuacauguuucacuuuga


acugaaagcuacucaaagccagccguaagucuaugguagaaugugauggaacauguugguggaagcuuguacaauagaac


acauuggugggagcuuguacauacuuuuuuauggagcauuacuuacgauuuuuuaaguaaaauguuuugaaaccaaaaaa


aaaaaaaggaauuc


 










Fgfbp1/Fibroblast
3
augagacuccacagccucauccugcucuccuuccuucuccuggcuacu
266


growth factor

caggcguucucagaaaaggucagaaagagagccaagaacgcaccacac



binding protein 1

agcacagcggaggaggggguagaggguucagcucccucguuagggaag



AF065441

gcccagaauaagcagagaagcaggacaucuaaaucucugacgcauggc





aaguuugucaccaaagaccaagccacaugcagaugggcugugacugag





gaggagcagggcaucagccugaagguccagugcacacaagccgaucag





gaguuuucuuguguuuuugcuggugacccaacugacugccuuaaacac





gacaaagaccagaucuacuggaaacagguugcccgcacgcugcgcaaa





cagaaaaauaucugcaggaacgccaagagugucuugaagaccagagug





ugcagaaagagauuuccagagucuaaccucaagcuggugaaccccaac





gcacguggaaacacgaagcccaggaaggagaaagcagaggucuccgca





agggagcacaacaagguccaagaagcugucuccacggagccaaacagg





gucaaagaagacaucacacucaauccagcugcgacccagaccauggcc





auuagagauccagagugucuagaggauccagaugugcucaaccagagg





aagaccgcccuggaguucugugggaaucuuggagcuccauuugcacau





ucuuccucaacauguuacaggcgacaucaugcuaa



 







Transcription Factors and Releated Genes


 










Klf5/Kruppel-
5

267


like factor 5





AA611766





 


Gata3/GATA
4
Sequence below.
268


binding protein 3





X55123










gcuaaacuaucccgcaaagauuuuucuuuccucccuaaacccuccuuuuugcucuccuuuucuauacccuuaacugcaaa


caaaccauuaaacgaccccucuccugggccuccgacggcaggaguccgcggaccucccaggccgacagcccucccucuac


ccgcgagguuccgggccgggcgagagggcgcgagcacagccgaggacauggaggugacugcggaccagccgcgcugggug


agccaccaucaccccgcgguccucaacggucagcacccagacacgcaccacccgggccucggccauucguacauggaagc


ucaguauccgcugacggaagagguggacguacuuuuuaacaucgauggucaaggcaaccacgucccguccuacuacggaa


acuccgucagggcuacggugcagagguauccuccgacccaccacgggagccagguaugccgcccgccucugcugcacgga


ucucugcccuggcuggauggcggcaaagcccugagcagccaccacaccgccucgcccuggaaccucagccccuucuccaa


gacguccauccaccacggcucuccggggccucuguccguuuacccuccggcuucauccucuucucuggcggccggccacu


ccaguccucaucucuucaccuucccgcccaccccgccgaaagacgucuccccagacccgucgcuguccaccccgggaucc


gccgggucggccaggcaagaugagaaagagugccucaaguaucaggugcagcugccagauagcaugaagcuggagacguc


ucacucucgaggcagcaugaccacccuggguggggccucauccucagcccaccaccccauuaccaccuauccgcccuaug


ugcccgaguacagcucuggacucuucccacccagcagccugcugggaggauccccuaccggguucggauguaagucgagg


cccaaggcacgauccagcacagaaggcagggagugugugaacugcggggcaaccucuaccccacuguggcggcgagaugg


uaccgggcacuaccuuugcaaugccugcggacucuaccauaaaaugaaugggcagaaccggccccuuaucaagcccaagc


gaaggcugucggcagcaaggagagcagggacauccugcgcgaacugucagaccaccaccaccacccucuggaggaggaac


gcuaauggggacccggucugcaaugccugugggcuguacuacaagcuucauaauauuaacagaccccugacuaugaagaa


agaaggcauccagacccgaaaccggaagaugucuagcaaaucgaaaaagugcaaaaaggugcaugacgcgcuggaggacu


uccccaagagcagcuccuucaacccggccgcucucuccagacacaugucaucccugagccacaucucucccuucagccac


uccagccacaugcugaccacaccgacgcccaugcauccgcccuccggccucuccuucggaccucaccacccuuccagcau


ggucaccgccauggguuagagaggcagagcccugcuccacaugcgugaggagucuccaagugugcgaagaguuccuccga


ccccuucuacuugcguuuuucgcaggagcaguaucaugaagcccgaaagcgacagaucuguguuuuugaaggcagaaagc


aaaauguuugcuucuuuuuucaaaggagcucgagguggugucugcauuccaaccacugaauccggaucccauuugugaau


aagccauucagacucauauucccuauuuaacagggucucuagugcugugaaaaaaauauugcugaacauugcauauaacu


uauauuguaagaaauacuguacauuugaggaagacuuuauuguaccuggauagcuguaagaaaggcaugaaggacgccaa


gaguuuuaaggaauauaggggnnuuaaaguauggagauacagaagaaaccacuaagucugauguccaaaugggcacacug


ucaguuuuguuucccuucaguuguuugaugcauuuaaaaaaaaaaaaaagaaagaa


 










Stimulated by
3
Sequence below.
269


retinoic acid 14,





basic-helix-





loop-helix protein





Y07836










caaccaccuccuaccugccugcccaaagcuccagggcuggagcacggagaccugucagggauggauuuugcccacaugua


ccaaguguacaaguccaggcggggaauaaaacggagcgaagacagcaaggaaacuuacaaacugccgcaccggcugauug


agaaaaagagacgugaccggauuaacgagugcauugcccagcugaaggaucuccuacccgaacaucucaaacuuacuacu


uugggucacuuggaaaaagcagugguucuggagcuuacguugaagcacgugaaagcauugacaaaucuaauugaucagca


gcagcagaaaaucauugcccugcagagcgguuuacaagcuggugauuugucgggaagaaaucucgaggcagggcaagaaa


uguucugcucagguuuccagacuugugcccgugagguacuucaguaccuggcgaagcaugagaacacucgggaccugaaa


ucuucccagcucgucacucaucuccaucguguggucucggagcugcugcaggguggugcuuccaggaaaccauuggacuc


ggcucccaaagccgucgacuugaaagagaagcccagcuuccuagccaagggaucagaaggcccagggaaaaacugugugc


cagucauccagcggacuuuugcucccucggguggggagcagagcggcagugacacggacacagacaguggcuauggaggu


gaauuggagaaaggggacuugcgcagugaacagccguacuucaaaagcgaccauggacgcagguucgccgugggagaacg


ugucagcacaauuaagcaagaauccgaagagccccccaccacaaagagccgaaugcagcucucagaagaggaaggccacu


ucgcgggcagugaucugauggguuccccauuucuugggccacacccacaucagccuccuuuuugccuucccuucuaucuc


aucccaccaucggccacugccuaccugccuaugcuggagaaaugcugguaccccaccucugugccaguguuauacccagg


ccucaacaccucagcugcagcccucuccagcuucaugaacccagacaagauaccgacucccuugcuucugccccagagac


ucccuucuccuuuggcacauucgucccuugacucuucggccuugcuccaggcuuugaagcagaucccuccuuuaaacuua


gaaaccaaagacuaaacucuggagggaucuccugcugccuugcuuucuuuccucccuaauuccaaaaaccacgaagguuu


cccugagugcagagagaucagcccacccugcagacccacagagaagauucagagugugugugagagugagugagugugcg


ugcgugcgugcuuguauguauguuuguauauguaggacaauaaguuccuucugacacaagggagacacgagaaggauagc


cugacaucagaugacagacuggaggacuguagcacaucucugggcguuucccuacccagagaagagcc


 










Mki67/antigen
4
Sequence below.
270


identified by





monoclonal





antibody Ki67





X82786










agucaccgacguuguauaacgacggccagugaauuguaauacgacucacuauagggcgaauuggguaccggccccccccu


cgaggucgacgguaucgauaagcuugauaucgaauucucgnccgcgugcgggucuggucggggcggagcgaaggccgcgg


guggccguggucgguccuccgcggcuaaggagccgagggcuccgacgcgggcugcgcccggugagcggcggccagagcua


acuugcgcugacuggaccagcugaggagcggcccggcggggcgacugcgagcuucaccgagaggcuucuccgcccugguc


cgcagucccgacggccgggcggaccauggcguccucggcucaccuggucaccaucaagcggagcggcgaugacggcgcac


acuucccgcugagccucagcuccugccuguuuggaaggaguauugaaugugacauucguauccagcugccuguagugucu


caaagacauugcccaauuguaguccaagagcaagaggcgauauuauauaauuucaguucuaccaauccaacucaaguaaa


cgggguuacuauagaugagccugugaggcugagacauggagacauaauaaccaucauugaccgcuccuuuagguaugaag


auggaaaucaugaggauggaagcaaaccaacagaauuuccaggaaagucccuuggaaaggaaccaucaaggcgagccuca


agagauagcuucugugcugacccugauggggaaggucaagauaccaaagcuucaaaaaugacugcuucaagaagaucuuu


uguguaugccaagggccuuucugcagauagcccugccucagauggcucaaagaacaguguuagccaagacucaucagggc


auguagaacagcacacuggcagaaacauaguagagcccacuucugggggaucucuuuuaagaaguccaggucuacaggga


gcaguuacagggaaccgaagucuucuuccuacacagagccuuagcaauagcaacgaaaaggaaucucccuuugagaaacu


uuaucaaucaaugaaggaagaguuggauguaaaaucccagaaaucuuguaggaaaucagaaccccaaccugaccgugcag


cagaggaaucgcgggagacacagcuauuggugucaggcagggcaagagcaaagucuaguggaagcaccccuguuacugca


gccucuucacccaaaguaggaaagaucuggacugagagauggcgcgguggaauggugccuguccagacuuccacagagac


agcuaaaaugaagaccccugugcggcauucacagcaacuuaaggaugaagacucucguguuacuggcagacgacauucug


ugaaucuggaugaagguggaagugcccaggcaguccauaaaacagucacuccugggaaacuggcgacuagaaaccaaacu


ccgguggaggcuggggauguuggcagccccgcugauacaccagaacauuccucuuccccccagagaaguauuccugcaaa


gguagaggcuccaucugcagagacacaaaaucggcucucuuuaacucagcgccuuguuccaggugaaaagaaaacuccca


aggguuccuucagcaagccugagaaacuggccacagccgccgaacagacuugcucuggccuaccuggucuuaguuccguu


gauaucagcaacuuuggugauuccauuaacaagagugagggaaugccuaugaagagaagacguguauccuuugguggaca


ucuaagaccugaauuauuugaugaaaacuugccuccuaauacaccacugaaaagaggagaaacgccaaccaagaggaagu


cucuuggcacucacagcccagcuguccucaagacaaucaucaaggaacggccccagucuccagggaaacaagagucuccu


gggauaacgccaccgaggacaaaugaucaaagacgcagaucaggcaggacuuccaguggaagcaauuucuuaugugagac


agacauucccaagaaagcaggcaggaagagcgguaaccugccugcgaagagagcauccaucagccggagucagcauggca


uucuacagaugauuugcuccaaaaggcgaaguggagcuucugaagccaacuugauuguugcaaaaucaugggcugauguu


guaaaacuuggcgugaaacaaacacaaacgaaaguugcgaaacaugucccuccaaagcagacgagcaagagacaaagaag


acccagcacuccaaagaaacccacaagcaaucuucacaaucaauuuacuacaggccaugcaaacucucccuguaccauug


uaguagguagagcgcagauugaaaaaguaagugugccugcccgacccuacaaaaugcugaauaacuugaugcuaaaccga


aaaguggacuucagugaagaucugucaggacuaacugaaauguucaagacuccagugaaggagaagcagcagcagaugag


ugauacaggcuccguacuuuccaauucagcgaauuugucugaaagacaauugcaaguaacuaauucaggagacauaccug


agcccaucaccacagagauuuugggagaaaaagugcuauccaguacucggaaugcagcaaagcagcagucugauagauau


ucugcaaguccuaccuuaagacggcggagcaucaaacaugaaaacacagugcaaacuccuaagaauguccauaacauuac


ugaccuugagaagaagacuccggucucugagacagagccccugaagacugcaucgagugugagcaaguuaagaagaucua


gagagcucagacauacccuuguggaaacuaugaaugaaaaaacagaagcaguccuugcugagaacaccacagcaagacau


uuaagggggacauuucgagaacaaaaaguagaucaacaggugcaggacaaugaaaacgcuccucaaagaugcaaggaaag


uggugaauuaagugaagguucagaaaagacaucagcuaggagaucaagugccaggaagcagaagccgacaaaagacuuac


uaggaagucagauggucacccaaacagcagacuaugcugaggaacuacuuagucaaggacaaggaaccauacaaaaccua


gaggaauccaugcacaugcaaaacacaucaauaagugaggaucaaggaauuacagaaaagaaagugaacauaauaguaua


ugcaaccaaagagaagcacucgccaaagaccccuggcaaaaaggcacaaccucuagaagggccagcuggucucaaggaac


acuuugaaacaccaaaccccaaagauaaaccuauaacggaagacagaacuagaguccuuugcaaaucaccacaagucaca


acagagaauaucacaacaaacacaaagccacagacuagcacaucugggaagaaaguagacaugaaggaagaaagcucugc


cuugacaaaacguauacauaugccaggggaauccaggcauaaucccaaaauuuuaaaacuugagugugaggauaucaaag


cuuugaagcaaucugaaaaugaaaugcugaccucaacaguaaauggaagcaagaggacuuuaggaaaaucuaaaaaaaag


gcucagccccuggaagaccugacuuguuuccaggaacucuuuauaucaccaguuccuacuaacauaaucaaaaaaauucc


cagcaaaucuccacacacaaccagucagaaccccagcgagcacaaagagacucuccaagacaggucucaguaaaguggau


gugagacaagaaccuucaacacuugggaaaagaacgaagucaccaggcagagccccaggcacaccagcaccagugcagga


agaaaaugacugcacagccuacauggaaacuccaaagcagaaacuggagucuauagaaaauuuaacagggcuuaggaaac


aguccagaacaccuaaagacaucacugguuuccaggauaguuuccaaauaccagaucaugcuaauggcccauuagugguu


gucaaaaccaaaaaaauguucuuuaauucuccacaaccagaaagugccauaacccgaaagagcagagagagacagucuag


ggcaaguauaaguaaaauagauguuaaagaagaacuuuuagaaucagaggaacaccuacaauuaggagaagguguagaca


cauuucagguauccaccaacaaagucauuagaucaucuaggaaaccugcaaagcguaaacuggauucaacagcugguaug


ccuaacagcaagaggaugcgcuguucuucaaaggauaacacaccaugccuagaagaccugaauggcuuccaagagcucuu


ccaaaugccaggcuaugcuaaugacucuuugaccacuggaaucucaacaaugcuugcuagaucaccacaauuaggaccag


uuagaacccaaaucaacaaaaagagucugcccaagaucaucuugagaaaaauggaugugacagaagaaauuucaggucuc


uggaagcagucacugggcagaguccacaccacacaagagcaggaggauaaugcaaucaaagcaauuauggagauuccaaa


ggaaacacugcagacugcagcagauggaacuaggcuuaccagacagccacaaacaccuaaggaaaaaguucaaccgcugg


aagaucacagugucuuccaagaacucuuccaaacaucacgcuacuguucugauccauuaauugguaacaaacaaacaaga


auguccuugagaucuccacaaccaggauuuguuagaacuccacgaaccucaaagagacuggcuaagacaaguguugggaa


uauugcugugagagaaaagaucucuccagugagucugccacagugugcuacaggggagguuguacacauacccauagggc


cagaagaugacacagagaacaaaggugugaaggaauccacaccucagacacuggacucaucagcaagucgaacugucagc


aagaggcagcaaggggcacaugaggaaaggccucaguucucaggagacuuauuucauccccaagagcucuuucaaacacc


agccaguggcaaagacccaguaacuguugaugaaacuacaaaaauagcucugcagucuccacaaccaggacauaucauaa


acccagcaagcaugaagagacaguccaacaugagucucaggaaagacaugagagaauuuuccauacuugaaaaacaaaca


cagucacgaggcagagacgcaggcacaccagcaccaaugcaggaagaaaauggcaccacagccauuauggaaacaccaaa


gcagaaacuggauuucauaggaaauucaacaggacauaagaggaggccucggacacccaaaaacagggcucagccccuag


aagaccuggauggcuuccaagaacucuuucaaacaccagcuggugccagugacccugugaguguugaagaaagugcaaag


auaucuuuggcaucuucacaagcagaaccagucagaaccccagcaaguacaaagagacgcuccaagacaggucucaguaa


aguggaugugagacaagaaccuucaacacuugggaaaagaaugaagucacuaggcagagccccaggcacaccagcaccag


ugcaggaagaaaaugacagcacagccuucauggaaacuccaaagcagaaacuggauuucacaggaaauucaucaggacau


aagaggaggccacagacaccuaagaucagggcucagccccuagaagaccuggauggcuuccaagaacucuuccaaacacc


agcuggugccaaugacucagugacuguugaggaaaguguaaagaugucuuuggaaucuucacaagcagaaccagucaaaa


ccccggcaagcacaaagagacucuccaagacaggucucaguaagguggaugugagagaagacccuucaauacuugagaaa


aaaacaaagucaccaggcacaccagcaccagugcaggaagaaaaugacugcacagccuucauggaaacuccaaagcagaa


acuggauuucacaggaaauucaucaggacauaagaggaggccacggacaccuaagaucagagcucagccccuagaagacc


uggauggcuuccaagaacucuuccaaacaccagcuggugcuagugacucagugacuguugaggaaagugcaaagaugucu


uuggaaucuucacaagcaaaaccagucaaaaccccggcaagcacaaagagacucuccaagacaggucucaguaaggugga


ugugagagaagacccuucaacacuugggaaaaaaacaaagucaccaggcagagccccaggcacaccagcaccagugcagg


aagaaaaugacagcacagccuucauggaaacuccaaagcagaaacuggauuuugcagagaauucaucagggaguaagaga


aggucacgaacaucuaagaacaggucucagccccuagaagaccuggauggcuuccaagaacucuuccaaacaccagcugg


ugccaguaacccugugaguguugaagaaagugcaaagauaucuuuggaaucuucacaagcagaaccagucagaacccggg


caagcacaaagagacuuuccaagacaggucucaauaagauggaugugagagaagggcacucuccgcucaguaagucaagc


ugugcaucacagaaagucaugcaaacccucacacuuggagaagaucauggcagagagaccaaagaugggaagguauuguu


agcucagaaauuggaaccagcaauauauguuacucguggcaagaggcagcaaaggucauguaagaaaaggucccaguccc


cagaagaccucucugguguucaggaggucuuccaaacaucaggccauaacaaggauucagugacaguggacaaucuugca


aaacugcccagcucgucuccaccacuagagccaacagacacuucaguaaccucacggagacaggccagaacuggucugag


gaaaguucacgugaaaaugaacuuucaggaggcauaaugcauccacaaauaucaggggaaauuguggacuuaccuagaga


accagaaggugaaggcaaagucauuaaaacaaggaagcaaucuguaaaacggaaauuggacacagaagucaaugugccuc


gcaguaagaggcaaagaauuacaagagcagaaaagacccuagaggaucugccuggcuuccaagagcucugccaagcucca


agcuugguaauggacucaguuauuguugagaaaaccccaaagaugcccgacaaaucuccagaaccuguggauacaacuuc


agagacacaggcaagaagaagacucaggagacugguuguuacugaagagcccauaccacaaagaaagacuacaagaguug


uaaggcaaaccagaaacacacagaaagagcccauaagugacaaucaagguauggaagaguuuaaggaaucuucaguacag


aaacaagacccaaguguaaguuuaacuggcaggaggaaccaaccaaggacaguuaaggagaaaacccaacccuuagaaga


acucaccaguuuccaagaggaaacugccaaaagaauaucuuccaaaucuccacaaccggaagagaaggaaaccuuagcag


guuuaaagaggcagcucagaauacaacuaaucaacgaugguguaaaagaagagcccacagcacagagaaagcaaccaucc


agggaaaccaggaacacacucaaagagccuguaggugacaguauaaauguugaagagguuaagaagucuacaaagcagaa


aauugauccaguagcaagugugccugucagcaagaggccacggaggguacccaaggaaaaggcacaggcccuagaauugg


cuggucucaaaggaccaauccaaacccuaggccacacugaugaaucagcaagugauaaaggacccacacagaugcccugu


aauucucuacaaccagagcaaguugacagcuuccaaagcucaccaaggcgacccaggacaagacgugggaaaguagaggc


agaugaagagccuucagcaguaagaaagacaguaucaacaucaaggcaaacuaugcgaucccgcaaggucccugaaauug


guaacaaugguacccaaguuucaaaggccuccauaaagcagacauuagauacaguagccaaaguaacuggcagcaggagg


cagcuaaggacacauaaaggaugggguucaacccucuugaaguuguuaggugacuccaaagaaauaacccaaauaucaga


ucacucugagaaacuagcacaugacaccaguauccuuaagagcacucaacagcaaaaagccagacucaguaaaaccucug


agaacaugcagaagagugcugagggccucuaaagagguccccaaggaaguguugguggacaccagagaccaugcaacauu


acaaagcaaaagcaacccuuugcuguccccgaagaggaagucugcaagagauggaagcauugugagaaccagggcuuugc


gcucuuuagcaccaaagcaggaagcaacagaugagaagccuguaccugagaaaaaaagggcugcuuccagcaagagguau


guaucaccugagccugugaagaugaaacaccugaaaaucgugucaaacaaacuugaaucuguggaagagcagguuagcac


uguuaugaaaacagaagaaauggaagccaaaagagaaaauccugucacuccagaucagaacucuagguaccgaaagaaaa


ccaauguaaaacagccaaggcccaaguuugaugcaucugcagagaaugucgggauaaagaaaaacgagaagacuaugaag


acugccucccaggagacagagcugcagaauccagaugauggagccaagaaaucuacaucucggggccaagucagugggaa


aagaacaugcuugaggucuagaggaacgacugagaugccccagccuugugaagcagaagagaaaacaagcaaaccagcug


cagaaaucuugauaaagccucaggaagagaaaggagucucuggagagucugauguuagguguuugagguccagaaaaacu


agagucgcuuuggacagugaaccuaagccaaggguaacucguggaaccaagaaagaugcaaaaacucugaaggaggauga


agacauuguaugcaccaagaaguuaagaacaagaaguuaagaacaagaaguuaccagaaaagugaaacuauguagcaaag


acauuuaagaaggaaaaguaaauuugacuuagugauaaguuccagugugguuuucaccuccaguguaaagaugaacugua


aauacuacugcuacugccugaguuuaaggaaggaagcuuugagcuuuccuggucauacucucuucagacgccaauggagg


ucaugaggaagaucaccagggaucucagcgcaauuacaguuuaggggugagcaggcagaaauguggcccucuguccuauc


caauaaagcucugaaauucgcugccaaaa


 










Cks2/CDC28
4
gacguagagccccuugcgcccgguuuccugaucccgcuuacuccucug
271


protein kinase

cgcgccggcaggauggcccacaagcagaucuacuacucagacaaguac



regulatory subunit

uucgaugagcacuacgaguaccggcaugucauguuacccagagaacuc



2, sim to cdk

ucuaaacaaguacccaaaacucaucugauguccgaagaggaguggagg



regulatory

agacuugguguccaacagagucuaggauggguucauuacaugauucau



subunit 2

gagccagaaccgcauauucuucucuuuagacgaccucuuccaaaagaa



AA681998

caacaaaaaugaagugcagcugggaucaucuaaucuuuuucaaauuua





auguauauguguauauaagguaguauucagugaauacuugaaaagugu





acaaaccuuucauccauaccugugcaugcgcuguauucuucacagcaa





cagagcucagucaaaugcaacugcaaguagg



 


Ccng2/Cyclin G2
3
Sequence below.
272


U95826










cuacccuagacaaucacggcuuagccggcgcgcggagucgaucgucucggucgcuagagcuguccugagcucgaacgguc


cgacgcccccgccgcgccgguccgugacgccggggccgacacgaugaaggauuugggggccaagcacuuggcagguggcg


aagggguucagcuuuucggauuguugaacuucuaccuggaacaagaacagagauaccaaccucgggaaaaagggcugauc


uugauggaggcuaccccggagaaugauaacacuuuguguucaagacugagaaaugccaaaguggaagauuuaagaaguuu


aacuaacuucuuuggaucuggcacugaaacuuucguucuggcugucaauauuuuggauagauucuuggcccuuaugaagg


ugaaaccgaaacaccuguccugcauuggcgucugcugcuuuuugcuggccgccaggcuggcggaagaagaaggugacguu


ccccccacgcacgacgugauccgcaucagucaguguaaaugcacagcgucugacauuaaacgcauggagaaaaucaucuc


agagaaacugcacuaugagcuggaagcuaccacugccuuaaacuuuuugcacuuguaccacgcgauuguauuuugucaca


cuucagaaaggaaggagauucucagccucgauaaacucgaagcgcagcugaaagcuugcaacugccgaguugucuucucc


aaagcaagaccaucuguauuagcucugugccuucucaauuuggaaauagaaacgauaaaauccguggaacugcuggaaau


ucucuugcuuguuaaaaaacauuugaagcucagcgacacugaauucuuuuacuggagggaacugguuucuaaaugucuag


cagaguauucuucgccucgcugcugcaagccugaucugaagaagcugguauggauuguuucgcgacgcacugcgcagaac


cuccacagcagcuacuacaguguuccugagcugcccacuaucccagagggggguugcuuugacggaagugaaagugagga


cucuggugaagacaugaguuguggagaggagagucucagcagcuccccacccagcgaucaggagugcaccuucuucuuug


acuuccaaguggcucagacacugugcuuuccaccauagaggaaucugacauuguucugugucagggaauuuauaagugug


uguaccuagguuucaaagcaauaaacuuggggguugaauaggguaguuuuccuagguuuccagccccccgucuagucagg


 










Prc1/Protein
3
aacuaccuugggcagguucuauuaacugcaccuaacucagacgugagu
273


regulator of

aggacagaaggaagcugucccgggcgaacugaggucacaaagacuugc



cytokinesis 1

uuuugauucaagagagaccuuaaaggcuaguuaugauaguuaaguaca



DNA segment,

aguuuuaacaucugguagcuaacuuuuuuucucuaccccguaauucua



Chr 7

cuaugacugcucuucuagagguccugaguucaaaucccagcaaccaca



AA856349

ugguggcucacaaccaucuauaaugggaucugaugcccucuucuggug





ugc









Thus, the transcripts identified in this Example, the proteins they encode, and the pathways in which the proteins participate, contribute significantly to induction of epidermal cells to differentiate into HF stem cells. Activation of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for enhancing EDIHN. In addition, inhibition of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for preventing EDIHN and eliminating hair follicles. In addition, inhibition of the transcripts, proteins, and pathways depicted in Table 5 is a method for enhancing EDIHN. In addition, activation of the transcripts, proteins, and pathways depicted in Table 5 is thus a method for enhancing EDIHN.
Example 10
Expression of Wnt-1 Inhibitors During the First Nine Days after Wounding Causes Pigmentation of New HF
Materials and Experimental Methods
In this Example, doubly transgenic mice expressing both tetO-Dkk1 and K5-rtTA were utilized. When these mice are fed chow formulated with 1 g/kg doxycycline (BioServ, Laurel, Md.), they express Dkk1, under the control of the K5 promoter, in the basal epidermis. The control mice also received doxycycline, but they were K5-rtTA negative and thus did not express Dkk1.
Results
A 1 cm2 wound was induced on the lower back of the doubly transgenic mice at 21 days or 50 days old. Mice were placed on doxycycline-containing chow immediately after wounding to induce Dkk1 expression, and then doxycycline was discontinued after completion of the re-epithelialization at 9 days after wounding. Dkk1 expression inhibits Wnt activity, which in turn induces follicle pigmentation. At 22 days after wounding, pigmented HF were observed in the excised skin after preparing the epidermal sheet (FIG. 23A-B). Control mice lacked pigmented HF (FIG. 24).
In other experiments, continued expression of Dkk1 after the 9-day period inhibited formation of new HF.
The findings of this Example show that pigmented HF can be produced by suppressing expression of Wnt1 or by inducing expression of Dkk1 during the period of re-epithelialization, then inducing expression of Wnt1. In addition, the findings of this Example show that factors that inhibit neonatal hair follicle formation (e.g. Dkk1) also inhibit EDIHN, thus further supporting the notion that hair follicles formed by EDIHN are similar to normal hair follicles.
Example 11
Inhibition of EDIHN by Epidermal Growth Factor Injection
21 day-old mice were wounded as described in previous Examples. Starting from day 11 after wounding, a time point corresponding to the point at which the wound had recently reepithelialized, 10 μL of 1 μg/ml EGF was injected into the wound bed. EGF was injected once per day after this point for a total of 5 days. Three days later, the skin was collected, and whole-mount EDIHN assays were performed. EGF prevented HF formation as assessed by gross morphology. In addition, whole mounts of control and treated skin were analyzed with anti-K17 antibody immunostaining. All mice injected with EGF (n=4) exhibited no new HF formation (FIGS. 25 A-B), while control mice (n=2) had many new HF, as expected. (FIGS. 25 C-D).
In an additional experiment, recombinant EGF (1 microgram (mcg)/microliter (mcl)) was injected at days 11, 13 and 15 after wounding. Skin was collected at 18 days after wounding and stained for K17 and alkaline phosphotase. Once again, administration of EGF inhibited EDIHN.
The findings of this Example show that EGF inhibits HF formation. Thus, inhibiting EGF, EGFR, or one of the pathways in which they participate increases EDIHN-induced HF formation.
Example 12
Enhancement of EDIHN by Inhibition of EGF Receptor
To determine the effect of administration of EGF receptor inhibitors on DIHN, the inhibitor AG1478 (150 μM in 10 μL volume) was administered as a single injection 11 days after incisional wounding (1 cm2) to the middle of the wound near the skin surface. EGF receptor inhibitor administration led to generation of more and larger hair follicles compared with control mice that were wounded only (FIG. 26A). As shown in FIG. 26B, large hair follicles developed in the wounded area in the AG1478-injected mice. Left panel: epidermis stained for K17, with three large hair follicles next to each other. Right panel: dermis stained for AP with large coalescing dermal papilla areas.
The findings of this Example confirm the results of the previous Example, and show that more and larger HF can be generated when EDIHN comprises, or is followed by, administration of EGFR inhibitors, or with compounds with a similar mechanism of action; e.g. Hedgehog protein and androgen antagonists.
Example 13
Enhancement of EDIHN by Expression of a β-Catenin Activator
To determine the effect of administration of β-catenin activators on EDIHN, K14-Wnt7 transgenic mice, which overexpress the β-catenin pathway activator, Wnt7, in the epidermis, were subjected to EDIHN, then HF formation was measured 19 days after wounding. In each of 2 separate experiments, with 4 week old and 3 week old mice, the transgenic mice developed significantly larger numbers of HF compared to control, non-transgenic littermate mice (FIG. 27 A-C).
Thus, administration of β-catenin activators leads to an increase in EDIHN. The findings of Examples 11-13 show that new HF can be generated by (a) disrupting the epidermis; and (b) administering a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell.
Example 14
Enhancement of EDIHN by Administration of FGF
To determine the effect of fibroblast growth factor (FGF) on EDIHN, recombinant FGF is administered 11 days after incisional wounding, as described in Example 11. FGF administration enhances HF formation, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering FGF, a nucleotide encoding FGF, or a factor that increases signaling by FGF.
Example 15
Enhancement of EDIHN by Administration of EDAR
To determine the effect of fibroblast growth factor (FGF) on EDIHN, K14-Eda-A1 transgenic mice, which overexpress (ectodysplasin-A1) Eda-A1 in the epidermis, are subjected to EDIHN, then HF formation is measured 19 days after wounding as described in Example 13. The transgenic mice developed significantly larger numbers of HF compared to control, non-transgenic littermate mice, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering a factor that enhances signaling by ectodysplasin.
Example 16
Enhancement of EDIHN by Administration of Minoxidil
To determine the effect of minoxidil on EDIHN, recombinant FGF is administered 11 days after incisional wounding, as described in Example 11. Minoxidil administration enhances HF formation, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering a minoxidil.
Example 17
Removal of HF by Abrasion and Administration of EGF
Hair-bearing regions of the epidermis of mice is abraded, as described in Example 1, then administering recombinant EGF, as described in Example 1. This method prevents hair re-growth in the abraded areas, showing that hair can be removed by (a) disrupting the epidermal layer; and (b) administering EGF, a nucleotide encoding EGF, or a factor that increases signaling by EGF.

## Claims

1. A method for enhancing hair follicle neogenesis in a scarred region of a subject, said method comprising:
(i) disrupting the basal and suprabasal epidermal layers of said scarred region of said subject; and
(ii) contacting the disrupted area of the scarred region of said subject with a compound comprising minoxidil, thereby enhancing hair follicle neogenesis in said scarred region of said subject.

2. The method of claim 1, wherein said disrupting is performed using a light-based method.

3. The method of claim 1, wherein said disrupting is performed using a laser.

4. The method of claim 3, wherein said laser is a CO2 laser, a fractional laser, or an excimer laser.

5. The method of claim 3, wherein said laser induces transepithelial injury.

6. The method of claim 1, wherein said disrupting is performed by abrading.

7. The method of claim 6, wherein said abrading comprises wearing away said epidermis or dermis by friction.

8. The method of claim 1, wherein said disrupting is performed using a mechanical method.

9. The method of claim 8, wherein said mechanical method comprises use of a tool that comprises sandpaper or a rotating felt wheel.

10. The method of claim 1, wherein said disrupting is performed by perforating.

11. The method of claim 10, wherein said perforating comprises use of a surgical tool.

12. The method of claim 11, wherein said surgical tool induces punch wounds.

13. The method of claim 1, wherein said disrupting is performed by freezing or cryoinjury.

14. The method of claim 1, wherein the step of contacting is performed 3-12 days after the step of disrupting.

15. The method of claim 1, wherein said subject is a human.

16. The method of claim 1, further comprising administering a lithium compound in an amount effective to stimulate hair growth in said scarred region.