Exhibit 10.8

 

WORK ORDER NO. 9

 

THIS WORK ORDER NO. 9 is by and between RADIUS HEALTH, INC. (“RADIUS”) and LONZA Sales Ltd, a Swiss company having an address at Muenchensteinerstrasse 38, CH-4002 Basel, Switzerland (together with its Affiliates, “Manufacturer”), and upon execution will be incorporated into the Development and Manufacturing Services Agreement between RADIUS and Manufacturer dated October 16, 2007 (the “Agreement”). Capitalized terms in this Work Order will have the same meanings as set forth in the Agreement.

 

RADIUS hereby engages Manufacturer to provide Services, as follows:

 

1.                                      API/Drug Substance and Product.

 

BA058

 

Peptide Sequence:  H-Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Glu-Leu-Leu-Glu-Lys-Leu-Leu-Aib-Lys-Leu-His-Thr-Ala-NH2

 

2.                                      Services.  Manufacturer will render to RADIUS the following Services:

 

Analytical Services:

 

·                  Bridging study stability: Price: 15,795€

·                  Mixing study: Price 3,625€

·                  LC/MS sequencing validation: Price 7,100€

·                  Dispensing of 2.5g of lot 7AL1 in aliquots of 50 mg (10 vials) and 100mg (15 vials): Price 2,185€

 

Manufacture of beta-asp-10 degradant

 

Following forced degradation of Lot 3AL1 via heating, Manufacturer will purify via HPLC to obtain approximately 1.5g of the beta-asp-10 degradant.

 

·                  Utilization of 21.9g net peptide weight of 3AL1 (Lonza owned material): Price 1750€/g

 

Total: 38,325€

 

·                  Purification and analysis: 23,275€

 

Radius shall place purchase orders with Manufacturer in accordance with Work Order 9, and the work will be initiated upon Manufacturer’s acceptance of the PO.

 

The deliverables will include regular updates (status reports, conference calls), as requested by RADIUS.

 

3.                                      Facilities.  The Services described above will be rendered at the Facility unless another facility of Manufacturer is indicated below:

 

N/A

 

4.                                      RADIUS Materials.  RADIUS will provide to Manufacturer the following materials to be used by Manufacturer to perform the Services:

 

None

 











 

5.                                      RADIUS Equipment.

 

None

 

6.                                      Manufacturer Representative.

 

Debra Sponholtz, Director, Sales and Business Development, Lonza

 

7.                                      RADIUS Representative.

 

David Hanley, Executive Director, Technical Operations

 

8.                          Compensation.  With the exception of the price for the starting material 3AL1 which will be invoiced in total (€38,325) upon signature of this Work Order, Radius will be invoiced 50% of the Services upon signature of this WO (€25,990) and 50% upon completion of each respective activity set forth above. The total compensation due Manufacturer for Services under this Work Order is not expected to exceed €90,305.

 

9.                          General: RADIUS and Manufacturer must agree in advance of either party making any change in the compensation due hereunder. Manufacturer will invoice RADIUS to the attention of David Hanley, for Services rendered under this Work Order.  Manufacturer will invoice RADIUS for all amounts due under this Work Order.  All undisputed payments will be made by RADIUS within thirty (30) days of receipt of invoice.

 

All other terms and conditions of the Agreement will apply to this Work Order.

 

	
WORK ORDER AGREED TO AND   ACCEPTED BY:
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
RADIUS HEALTH, INC.
    	
 
    	
LONZA SALES LTD
    
	
 
    	
 
    	
 
    
	
By
    	
/s/ G. Williams
    	
 
    	
By
    	
ppa /s/ M. Maskus
    
	
 
    	
 
    	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    	
 
    	
 
    
	
Print Name
    	
G. Williams
    	
 
    	
Print Name
    	
M. Maskus
    
	
Title
    	
Chief Development   Officer
    	
 
    	
Title
    	
Assoc. Director Comm   Develop
    
	
Date
    	
29 April 2015
    	
 
    	
Date
    	
07-May-2015
    
	
 
    	
 
    	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    	
By
    	
ppa /s/ N. Zieger
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    	
 
    
	
Approved   by BGL,
    	
 
    	
Print Name
    	
Nadia Zieger
    
	
Lonza   Legal Dept.
    	
 
    	
Title
    	
Senior Legal Counsel
    
	
 
    	
 
    	
Date
    	
6 May 2015