| (Mark One) |                                                                                                       |
|------------|------------------------------------------------------------------------------------------------------------|
| R          | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934                       |
|       | For the fiscal year ended December 31, 2010                                                                |
|       | or                                                                                                         |
| £     | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 (NO FEE REQUIRED) |
|       | For the transition period from ____________ to ____________                                                |

| Delaware                                 | 26-0734029          |
|------------------------------------------|---------------------|
| (State or Other Jurisdiction of          | (I.R.S. Employer    |
| Incorporation or Organization)           | Identification No.) |
|                                     |                |
| 850 Shades Creek Parkway, Suite 200      | 35209               |
| Birmingham, Alabama                      | (Zip Code)          |
| (Address of Principal Executive Offices) |                |

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|                                                                                                                              | Page |
|-----------------------------------------------------------------------------------------------------------------------------------|------|
| Report of Independent Registered Public Accounting Firm on    Consolidated Financial Statements               | 66   |
| Report of Management on Internal Control over Financial Reporting                                                                 | 67   |
| Report of Independent Registered Public Accounting Firm on     Internal Control over Financial Reporting | 68   |
| Consolidated Balance Sheets at December 31, 2010 and 2009                                                                         | 69   |
| Consolidated Statements of Income for the Years Ended December 31,    2010, 2009 and 2008                     | 70   |
| Consolidated Statements of Comprehensive Income for the Years Ended    December 31, 2010, 2009 and 2008       | 71   |
| Consolidated Statements of Stockholders’ Equity for Years Ended    December 31, 2010, 2009 and 2008     | 72   |
| Consolidated Statements of Cash Flows for the Years December 31, 2010,    2009 and 2008                       | 73   |
| Notes to Consolidated Financial Statements                                                                                        | 75   |

|   | (b)   | The following exhibits are furnished with this report. |
|--------|-----------------|--------------------------------------------------------|

| EXHIBIT NO. |   | NAME OF EXHIBIT                                                                                 |
|-------------|--------|-------------------------------------------------------------------------------------------------|
|        |   |                                                                                            |
| 2.1         |   | Plan of Reorganization and Agreement of Merger dated August 29, 2007 (1)                        |
|        |   |                                                                                            |
| 3.1         |   | Certificate of Incorporation (1)                                                                |
|        |   |                                                                                            |
| 3.2         |   | Certificate of Amendment to Certificate of Incorporation (1)                                    |
|        |   |                                                                                            |
| 3.3         |   | Bylaws (1)                                                                                      |
|        |   |                                                                                            |
| 4.1         |   | Form of Common Stock Certificate (1)                                                            |
|        |   |                                                                                            |
| 4.2         |   | Certain provisions from the Certificate of Incorporation (1)                                    |
|        |   |                                                                                            |
| 4.3         |   | Revised Form of Common Stock Certificate (2)                                                    |
|        |   |                                                                                            |
| 4.4         |   | Amended and Restated Trust Agreement of ServisFirst Capital Trust I dated September 2, 2008 (3) |
|        |   |                                                                                            |
| 4.5         |   | Indenture dated September 2, 2008 (3)                                                           |
|        |   |                                                                                            |
| 4.6         |   | Guarantee Agreement dated September 2, 2008 (3)                                                 |
|        |   |                                                                                            |
| 4.7         |   | Form of  Common Stock Purchase Warrant dated September 2, 2008 (3)                    |
|        |   |                                                                                            |
| 4.8         |   | ServisFirst Bank 8.5% Subordinated Note due June 1, 2016 (6)                                    |

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| 4.9    |   | Warrant to Purchase Shares of Common Stock dated June 23, 2009 (6)                                                                          |
|--------|--------|---------------------------------------------------------------------------------------------------------------------------------------------|
|   |   |                                                                                                                                        |
| 4.10   |   | Amended and Restated Trust Agreement of ServisFirst Capital Trust II, dated March 15, 2010 (7)                                              |
|   |   |                                                                                                                                        |
| 4.11   |   | Indenture, dated March 15, 2010, by and between ServisFirst Bancshares, Inc. and Wilmington Trust Company (7)                               |
|   |   |                                                                                                                                        |
| 4.12   |   | Preferred Securities Guaranty Agreement, dated March 15, 2010, by and between ServisFirst Bancshares, Inc. and Wilmington Trust Company (7) |
|   |   |                                                                                                                                        |
| 10.1   |   | 2005 Amended and Restated Stock Incentive Plan  (1)*                                                                              |
|   |   |                                                                                                                                        |
| 10.2   |   | Change in Control Agreement with William M. Foshee dated May 20, 2005 (1)*                                                                  |
|   |   |                                                                                                                                        |
| 10.3   |   | Change in Control Agreement with Clarence C. Pouncey III dated June 6, 2006 (1)*                                                            |
|   |   |                                                                                                                                        |
| 10.4   |   | Employment Agreement of Andrew N. Kattos dated April 27, 2006 (1)*                                                                          |
|   |   |                                                                                                                                        |
| 10.5   |   | Employment Agreement of G. Carlton Barker dated February 1, 2007 (1)*                                                                       |
|   |   |                                                                                                                                        |
| 10.6   |   | 2009 Stock Incentive Plan (4)*                                                                                                              |
|   |   |                                                                                                                                        |
| 11     |   | Statement Regarding Computation of Earnings Per Share is included herein at Note 21 to the Financial Statements in Item 8.                  |
| 14     |   | Code of Ethics for Principal Financial Officers (5)                                                                                         |
|   |   |                                                                                                                                        |
| 21     |   | List of Subsidiaries                                                                                                                        |
|   |   |                                                                                                                                        |
| 23     |   | Consent of Independent Registered Public Accounting Firm                                                                                    |
|   |   |                                                                                                                                        |
| 24     |   | Power of Attorney                                                                                                                           |
|   |   |                                                                                                                                        |
| 31.1   |   | Section 302 Certification of Chief Executive Officer                                                                                        |
|   |   |                                                                                                                                        |
| 31.2   |   | Section 302 Certification of Chief Financial Officer                                                                                        |
|   |   |                                                                                                                                        |
| 32.1   |   | Section 906 Certification of Chief Executive Officer                                                                                        |
|   |   |                                                                                                                                        |
| 32.2   |   | Section 906 Certification of Chief Financial Officer                                                                                        |

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|   | SERVISFIRST BANCSHARES, INC. |                                  |
|--------|------------------------------|---------------------------------------|
|   |                         |                                  |   |
|   | By:                          | /s/ Thomas A. Broughton, III     |   |
|   |                         | Thomas A. Broughton, III              |   |
|   |                         | President and Chief Executive Officer |   |
|   |                         |                                  |   |

| Signature                     |   | Title                            | Date           |
|-------------------------------|--------|----------------------------------|----------------|
|                          |   |                             |           |
| /s/Thomas A. Broughton, III   |   | President, Chief Executive       | April 14, 2011 |
| Thomas A. Broughton, III      |   | Officer and Director (Principal  |           |
|                          |   | Executive Officer)               |           |
|                          |   |                             |           |
| /s/ William M. Foshee         |   | Executive Vice President         | April 14, 2011 |
| William M. Foshee             |   | and Chief Financial Officer      |           |
|                          |   | (Principal Financial Officer and |           |
| Principal Accounting Officer) |   |                             |           |
|                          |   |                             |           |
| *                             |   | Chairman of the Board            | April 14, 2011 |
| Stanley M. Brock              |   |                             |           |
|                          |   |                             |           |
|                          |   |                             |           |
| *                             |   | Director                         | April 14, 2011 |
| Michael D. Fuller             |   |                             |           |
|                          |   |                             |           |
|                          |   | Director                         | April 14, 2011 |
| James J. Filler               |   |                             |           |
|                          |   |                             |           |
| *                             |   | Director                         | April 14, 2011 |
| Joseph R. Cashio              |   |                             |           |
|                          |   |                             |           |
| *                             |   | Director                         | April 14, 2011 |
| Hatton C. V. Smith            |   |                             |           |

| /s/ William M. Foshee             |   |   |   |
|-----------------------------------|--------|--------|--------|
| William M. FosheeAttorney-in-Fact |   |   |   |

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| EXHIBIT NO. |   | NAME OF EXHIBIT                                          |
|-------------|--------|----------------------------------------------------------|
|        |   |                                                     |
| 23          |   | Consent of Independent Registered Public Accounting Firm |
|        |   |                                                     |
| 31.1        |   | Section 302 Certification of Chief Executive Officer     |
|        |   |                                                     |
| 31.2        |   | Section 302 Certification of Chief Financial Officer     |
|        |   |                                                     |
| 32.1        |   | Section 906 Certification of Chief Executive Officer     |
|        |   |                                                     |
| 32.2        |   | Section 906 Certification of Chief Financial Officer     |

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