Thiacloprid Dietary Exposure and Risk Assessment DP Number: 405299

Page 3 of 20 

### point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety
facto rs. For acute and non

- cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk exceeds
one in one million. References that discuss the acute and chronic risk as sessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21

- JUN

- 2000, web link: http://www.epa.gov/fedrgstr/EPA

PEST/2000/July/Day

- 12/6061.pdf ; or see SOP 99.6 ( 20

- AUG

- 1999).

The most recent dietary risk assessment for thiacloprid was conducted by D. Soderberg ( 23

- June

2003, DP289292 ). As indicated previously, this assessment was partially refined using average residue field trial data and percent crop treated data. Recent changes in the toxicological endpoints and FQPA safety factor have made these refinements no longer required in the acute
and non

- cancer chronic assessments, but the refinements are st ill being utilized for the cancer analysis.

II. Residue Information

Thiacloprid is a neonicotinoid insecticide that is currently approved for u se on cotton and pome fruit (Group 11)

. The residue chemistry data supporting these crop uses were summarized by
HED in a June 11, 2003 memo (DP# 279818

, D. Soderberg ). Tolerances are currently established [40 CFR §180. 594 ] for the combined residues of the insecticide thiacloprid ([3

- [(6

- chloro

- 3

- pyridinyl)methyl]

- 2

- thiazolidinylidene] cyanamide) and metabolites retaining the thiazolidine ring intact, measured and expressed in terms of thiacloprid, per se , in/on pome fruit, group 11 at 0.30 ppm; wet apple pomace at 0.60 ppm, cotton, undelinted seed at 0.02 ppm; cotton gin byproducts at 11.0 ppm ; and an imal commodities at 0.02

- 0.15 ppm

. For the new uses on stone fruits and peppers, the HED

- recommended tolerances are summarized in Table 1.

Table 1

. Tolerance Summary for Thiacloprid Proposed New Uses
Commodity Recommended
Tolerance (ppm) Comments; Correct Commodity

Definition

P epper (bell and non

- bell) 1.0 P epper , recommended tolerance is
harmonized with the Codex MRL.

S tone Fruit , except plum 0.5 F ruit , stone, group 12

- 12

, except plum

, recommended tolerance is
harmonized with the Codex MRL.

Plum 0.0 5 Plum

The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 2009,
and 2010. Over this 3

- year period, PDP analyzed 1479 samples of catfish for thiacloprid residues. None of the samples contained detectable residues. As a result, residues in fish were
not included in the assessment.

Processing FactorsThiacloprid Dietary Exposure and Risk Assessment DP Number: 405299

Page 4 of 20 

### For the existing uses on pome fruits, processing studies were previously reviewed and found to be adequate (D. Soderberg, DP279818, 11

- June

- 2003 ). For this analysis, the same empirical processing factors were utilized as in the 2003 dietary exposure assessment for processed apple and pear commodities. For the new uses on stone fruit and peppers, processing studies on stone fruit were submitted and recently reviewed (M. Doherty, D3 78298

, 01

- Feb

- 2011 ). Empirically derived processing factors were calculated based on these studies on dried peaches and plums. For all other processed comm odities, default processing factors were u sed . The processing factors utilized in this assessment (acute, chronic, and cancer) are summarized in Table 2.

Table 2

. Processing Factors for Thiacloprid Commodity Processing Factor Reference Apple, dried 0.51x D289292 Pear, dried 0.51x D289292 Apple

, juice 0.23x D289292

Pear

, juice 0.87x D289292 Applesauce 0.68x D289292 Peeled apples 0.82x D289292 Peach, dried 3.6x D378298 Plum, prune 3.1x D378298 Plum, juice 1.4x Default (DEEM 7.81) Apricot, dried 6.0x Default (DEEM 7.81) Beef, meat, dried 1.92x Default (DEEM 7.81) Cherry, juice 1.5 x Default (DEEM 7.81)

Acute and Chronic Assessment Inputs

For the acute and chronic assessments, unrefined assessments were completed, with tolerance

level residues and the assumption of 100% CT being made for all existing and proposed new

uses. In addition, tolerance

- level residues were used for the associated livestock tolerances. There are no livestock feedstuffs associated with the reque st to establish tolerances on peppers
and stone fruit. Thus, these new uses have no impact on the existing livestock tolerances. Empirical or default processing factors were used as described above for processed commodities

.

Cancer Assessment Inputs

With the exception of cottonseed oil, t he cancer assessment was partially refined to include average residue field trial data for the existing and proposed new uses. These average residues
are summarized in Table 3. For cottonseed oil, the existing toler ance of 0.020 ppm for cottonseed was utilized, as there is no separate tolerance for cottonseed oil. Consistent with HED SOP 2000.1, t he average residue from the pear field trial of 0.141 ppm was used as a conservative estimate of the anticipated residue from other pome fruits, including loquat and quince; the average apple field trial residue of 0.066 ppm was translated to crabapple . Simil arly, the average residue from the peach field trial of 0.167 ppm was translated to other stone fruits, specifically apricot and nectarine. Default or empirical processing factors were used as described previously for processed commodities . In addition, PCT data was used as appropriate for the existing and proposed new uses, as discussed below in Section III.Thiacloprid Dietary Exposure and Risk Assessment DP Number: 405299

Page 5 of 20 

### Table 3

. Average Residue Field Trial Data for Thiacloprid Cancer Assessment Commodity Average Residue (ppm) Reference Apple Crabapple a 

### 0.066 D279818

Pear Loquat b


### Quince b 

### 0.141 D279818

Cherry 0.162 D279818

Peach Apricot c



### Nectarine c 

### 0.167 D378298

Plum

Prune 0.016 D378298

Bell Pepper 0.053 D378298

Non

- Bell Pepper 0.077 D378298

a Translated from apple.

b Translated from pear.

c Translated from peach.



### In the 2003 assessment, the anticipated dietary burden associated with livestock commodities
was calculated. As there are no livestock commodities associated with the proposed new uses on stone fruit and peppers, the anticipated dietary burden remains unc hanged. Therefore, the values
from the 2003 assessment for the chronic anticipated dietary burden in cattle were used in this
cancer assessment. These values are summarized in Table 4 , with the values in cattle being translated to the appropriate tissues in goat and sheep. HED previously concluded that there is no reasonable expectation of residues in swine and poultry given current uses, per 40 CFR 180.6(a)3. Therefore, residues are not applied to swine and poultry (i.e. are set to zero) in this
assessment and no livestock tolerances have been established for swine and poultry
commodities. For further infor mation, including the details for th e s e anticip ated dietary burden
calculation s , please refer to D. Soderberg, D289292, 23

- June

- 2003.

Table 4

. Chronic Anticipated Residues in Cattle for Thiacloprid Cancer Assessment

Tissue Chronic Anticipated Residue (ppm)

Muscle 0.0001

Liver 0.0006 * Kidney 0.0002

Fat 0.0001

Milk 0.0001

*Value also used for meat byproducts

I I I. Percent Crop Treated Information

The acute and chronic dietary risk assessments assumed 100% CT for all existing and proposed

new uses.Thiacloprid Dietary Exposure and Risk Assessment DP Number: 405299

Page 6 of 20 

### The following average percent crop treated estimates ( A. Grube, D372886, 02

- Feb

- 2010 ) were
used in the cancer dietary risk assessment for the following crops that are currently registered for thiacloprid : apples: 10 % ; and pears: 5%.

The following projected percent crop treated estimates ( J. Alsadek, D382568, 09

- 26

- 2012 ) were used in the cancer die tary risk assessments for the following crops that are the subject of this petition for residues of thiacloprid : peaches : 4 3 %; and pe ppers : 45 %

.

IV. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the Environmental Fate and Effects Division (EFED) in the following memorandum: “ Thiacloprid: Update of the Drinking Water Exposure Assessment for Section 3 New Uses on Stone Fruits and Peppers ” (D 376184, G. Orrick, 07/12/2012 ) and incorporated directly in to this dietary assessment. Water residues were incorporated in the DEEM

- FCID into the food categories “water, direct, all sources” and “water, indirect, all sources.” Table 5 summarizes the drinking water estimates for thiacloprid in surface water and g roundwater, which are based on the highest use pattern scenario associated with the existing use on pome fruits. The surface water EDWCs were generated using the Pesticide Root Zone Model linked with the Exposure Analysis Modeling System (PRZM/EXAMS) and the ground water estimates are from the Screening
Concentration In GROund Water (SCI

- GroW) Model. The models and their descriptions are
available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/

.

The surface water results from the PRZM/EXAMS models were entered in each case for the acute, chronic, and cancer assessments. For the acute point estimate, the 1

- in

- 10

- year annual
maximum c oncentration estimate of 0.018 ppm was entered . For the chronic point estimate, the

1

- in

- 10

- year annual mean concentration estimate of 0.0023 ppm was entered . For the cancer assessment, the overall 30

- year mean concentration estimate of 0.0012 ppm was entered

. All of
these PRZM/EXAMS surface water estimates are protective of the ground water exposure
estimates from the SCI

- GROW model.

It is noted that the drinking water estimates used in this assessment have been refined to account for both percent crop ped area and for th e impact of drinking water treatment processes.

T hiacloprid and its amide are the only residues of concern in untreated drinking water. Following drinking water treatment, thiacloprid is the only residue of concern expected to be potentially present. Th is is because the submitted drinking water treatment study data indicate that 1) coagulation does not remove thiacloprid or thiacloprid

- amide from source water, 2) a typical oxidant (sodium hypochlorite) removes thiacloprid

- amide (but not thiacloprid), and 3) HED has determined that the four major treatment products of thiacloprid

- amide are not residues
of concern. HED determined that the treatment products of thiacloprid

- amide are not residues of concern due to the fact that they do not contain the thiazo lidine ring. Because surface water sourced drinking water is typically treated, thiacloprid is the only compound of concern for the
surface water estimates

. The ground water estimates listed below include both thiacloprid and thiacloprid

- amide as they will not always be treated, whereas the surface water estimates include only thiacloprid.Thiacloprid Dietary Exposure and Risk Assessment DP Number: 405299

Page 7 of 20 

### Table 5 . Total Residue EDWCs in Surface Water and Ground Water for Use in Dietary Risk
Asse ssment Based on the Use Pattern of Maximum Exposure, Pome Fruits

.

Use (maximum rate) Source PCA (%) 1

- in

- 10

- year Peak Exposure (ppb) 1

- in

- 10

- year

Annual Mean Exposure (ppb) 30

- year Mean

Exposure (ppb)

Pome fruits (0. 5 0 lbs a.i./A/year) Surface water (treated) 91 18 2.3 1.2

Ground water (untreated) N/A 0.25 0.25 < 0.25



### V. DEEM

- FCID Program and Consumption Information

Thiacloprid acute and chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database DEEM

- FCID,
Version 3.16 , which incorporates consumption data from USDA’s NHANES/WWEIA. This dietary survey was conducted from 2003 to 2008. The data are based on the reported consumption of more than 20,000 individuals over two non

- consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked to EPA

- defined food commodities (e.g.

, apples, peeled
fruit

- cooked; fresh or N/S; baked; or wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chr onic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups . However , for acute exposure assessment

, consumption data are retained as individual consumption events. Based on analysis of the 2003

- 2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19,
adults 20

- 49, females 13

- 49, and adults 50+ years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or food

form (e.g., orange or orange juice) on the food commodit y residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake
estimates for all other fo od/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup.

For an acute exposure a ssessment, individual one

- day food consumption data are used on an
individual

- by

- individual basis. The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only tho se who reported eating relevant commodities/food forms) and a per

- capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for a nalyses p erformed at all levels of refinement . However, for
deterministic assessments , any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.Thiacloprid Dietary Exposure and Risk Assessment DP Number: 405299

Page 8 of 20 

### VI. Toxicological Information

Table 6 summa rizes the toxicological endpoints for acute, chronic, and cancer dietary exposure

assessments. For acute dietary exposure assessments (all populations) , the NOAEL of 4.4 mg/kg/day from the developmental neurotoxicity study in rat s was used for risk assess ment,
based on offspring effects of altered performance in passive avoidance testing at a LOAEL of 25.6 mg/kg/day. The acute neurotoxicity study in rats was selected as a co

- critical study, based on reductions in motor and locomotor activity at the LOAEL o f 11 mg/kg/day (NOAEL = 3.1 mg/kg/day). For chronic dietary exposure, the NOAEL of 1.2 mg/kg/day from the combined chronic/carcinogenicity study in rats was used for risk assessment, based on liver and thyroid effects in males, and retinal degeneration in females at the LOAEL of 2.5 mg/kg bw/day. HED
has concluded that the 10x FQPA Safety Factor ( for the protection of infants and children ) can
be reduced to 1x. This decision was based on multiple factors, with the rationale described in
detail in the forthcoming risk assessment associated with this new use petition (M. Doherty,

D376178 ).

Thiacloprid is classified as, “Likely to be Carcinogenic to Humans,” based on an increased incidence of uterine tumors in rats, thyroid follicular cell adenoma s in rats (both sexes), and
ovarian tumors in the mice. A linear low

- dose approach for cancer risk was recommended for thiacloprid, a Q 1 

### * of 4.06 x 10 - 2 

### was calculated based on the incidence of combined uterine
tumors in female rats.

Table 6. Toxicolo gical Doses and Endpoints for Thi a cloprid for Use in Dietary Human Health Risk
Assessments Exposure/Scenario Point of

Departure Uncertainty/FQP

A Safety Factors RfD, PAD/ Level of

Concern for Risk
Assessment Study and Toxicological
Effects

Acute Dietary All Populations NOAEL =

4.4 mg/kg/day UF A =10x

UF H = 10x FQPA SF =1x aRfD=0.0 44

mg/kg/day

a PAD=0.0 44 mg/kg/day Co

- Critical Studies

Developmental Neurotoxicity Study

- rat LOAEL=25.6 mg/kg bw based on offspring effects of altered performance in passive avoidance testing.

Acute Neurotoxicity Study

– rat LOAEL = 22 mg/kg bw based
on a reduction of motor and locomotor activity in females (NOAEL = 3.1 mg/kg bw).

Chronic All Populations including
Infants/Children NOAEL =

1.2 mg/kg/day UF A =10x

UF H =10x FQPA SF =1x cRfD =0.012

mg/kg/day

cPaD =0.012 Chronic/Carcinogenicity Study

rat LOAEL = 2.5/3.3 (M/F) mg/kg
bw based on liver hypertrophy and cytoplasmic changes as well as induction of enzymes, thyroid epithelial hypertrophy
in males and retinal degeneration in females.

Cancer “Likely to be Carcinogenic to Humans” based on thyroid tumors in male rats, uterine tu mors

in rats and ovarian tumors in mice. Quantification is Q 1 * (mg/kg/day) - 1 = 4.06 x 10 - 2Thiacloprid Dietary Exposure and Risk Assessment DP Number: 405299

Page 9 of 20 Point of Departure (POD) = A data point or an estimated point that is derived from observed dose

- response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no obs erved adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (intraspecies). UF H = potential variation in sensitivity among members of the human population (interspecies). UF L = use of a LOAEL to extrapolate a

NOAEL. UF S = use of a short

- term study for long

- term risk assessment. UF DB = to account for the absence of key data (i.e., lack of a critical study). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD

- = reference dose. MOE = margin of exposure. LOC = level of concern. N/A = not applicable.

HEC = human equivalent concentration; HED = human equivalent dose.



### VII. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds
100% of the PAD. The DEEM

- FCID analyses estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table 7 are for the general U.S. Population, a ll infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19,
females 13

- 49, adults 20

- 49, and adults 50

- 99 years. Cancer risk is determined for the general U.S. population only.

Risk estimates are below HED’s level of concern for the U.S. population and all population subgroups for all acute and non

- cancer chronic exposure scenarios.

For the cancer dietary assessment (food and drinking water), t he estimated exposure of the general U.S. population to thiacloprid is 0.000049 mg/kg/day. Applying the Q* of 4.06 (mg/kg/day) - 1 

### to the exposure value results in a cancer risk estimate of 2 .0 x10 - 6



### . It is noted that drinking water is the primary driver of this risk estimate . The cancer risk estimate is 9. 7 x10 - 7 

### for food only.

Ta ble 7 . Summary of Dietary ( Food and Drinking Water ) Exposure and Risk for Thiacloprid

Population Subgroup Acute Dietary ( 95th Percentile) Chronic Dietary Cancer

Dietary Exposure (mg/kg/day) % aPAD* Dietary Exposure (mg/kg/day) % cPAD* Dietary Exposure (mg/kg/day) Risk

General U.S. Population 0.002745 6 .2 0.000612 5.1 0.000049 2.0x 10 - 6

All Infants (<1 year old)* 0.008329 19 0.001936 16



### N/A N/A Children 1

- 2 years old* 0.007996 18 0.003106 26

Children 3

- 5 years old 0.005457 12 0.001859 16

Children 6

- 12 years old 0.003399 7.8 0.000961 8.0

Youth 13

- 19 years old 0.001901 4 .3 0.000444 3.7

Adults 20

- 49 years old 0.001852 4 .2 0.000380 3.2
Adults 50+ years old 0.001768 4 .0 0.000414 3.5

Females 13

- 49 years old 0.001867 4 .2 0.000388 3.2

*The subpopulation(s) with the highest risk estimates are bolded.



### VIII. Characterization of Inputs/Outputs

As the exposure estimates to all population subgroups are below HED’s level of concern, it was not necessary to make refinements to the acute or non

- cancer chronic dietary analysis. If it hadThiacloprid Dietary Exposure and Risk Assessment DP Number: 405299

Page 10 of 20 

### been necessary to refine these analyses, field trial values or monitoring data could have been used in place of tolerance

- level residues. In addition, estimates of percent crop treated could
have been used.

In the case of the cancer dietary assessment, a partially refined assessment was conducted, using average field trial data and percent crop treated data. This assessment could have been refined further using monitoring data for the existing uses , but as the drinking water is the prim ary risk
driver

, such refinements would likely not significantly lower the risk estimate . Monitoring data is not available for thiacloprid in drinking water. The drinking water residues used in this assessment have been par tially refined to account for percent crop treated area and drinking
water treatment processes. However, the se drinking water estimates are still considered to be
conservative and upper

- bound

. It is also noted that the earlier 2003 assessment for the exi sting uses on pome fruit and cotton had a cancer risk estimate for food + drinking water of 2.6 x 10 - 6



### . Refinements in the toxicological endpoints and drinking water estimates, as well as updated percent crop treated data

, have resulted in a lower cancer risk estimate in this assessment , while still adding the new uses on stone fruit and peppers.

IX. Conclusions

With the exception of the utilization of empirical processing factors for available pome and stone fruit commodities, an unrefined tolerance

- level residue assessment was conducted for the acute
and non

- cancer chronic dietary analysis. All risk estimates for the U.S. population and population subgroups were below HED’s level of concern in the acute and non

- cancer dietary exposure assessment. T he cancer dietary exposure assessment was partially refined, including the use of average field trial data, and percent crop treated data. Drinking water was the primary
risk driver in the cancer assessment. HED is confident that the assessment does not underestimate risk to the general U.S. populat ion or any population subgroup.

X. List of Attachments

• Attachment 1

- Acute R esidue Input file

• Attachment 2

- Acute Results file

• Attachment 3

- Chronic Residue Input file

• Attachment 4

- Chronic Results File

• Attachment 5

- Cancer Residue Input file

• Attachment 6

- Cancer Results File

• Attachment 7

- Percent Crop Treated Data from BEADThiacloprid Dietary Exposure and Risk Assessment DP Number: 405299

Page 11 of 20 

### Attachment 1

– Acute Residue Input File for Thiacloprid

Filename: F: \ Thiacloprid \ New dietary \ THIACLOPRID AC UTE TOL.R08 Chemical: thiacloprid RfD(Chronic): .012 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .044 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Q*= .0406 Date created/last modified: 09

- 28

- 2012/17:00:42 Program ver. 3.16, 03

- 08

- d

Comment: THIS R98 FILE WAS GENERATED USING THE CONVERT TO R98 UTILITY VERSION 1.1.2.

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment

Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0802270000 8B Pepper, bell 1.000000 1.000 1.000 0802270001 8B Pepper, bell

- ba byfood 1.000000 1.000 1.000 0802271000 8B Pepper, bell, dried 1.000000 1.000 1.000 0802271001 8B Pepper, bell, dried

- babyfood 1.000000 1.000 1.000 0802272000 8BC Pepper, nonbell 1.000 000 1.000 1.000 0802272001 8BC Pepper, nonbell

- babyfood 1.000000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 1.000000 1.000 1.000 1100007000 11 Apple, fruit with peel 0.300000 1.000 1.000

1100 008000 11 Apple, peeled fruit 0.300000 0.820 1.000 1100008001 11 Apple, peeled fruit

- babyfood 0.300000 0.820 1.000 1100009000 11 Apple, dried 0.300000 0.510 1.000 1100009001 11 Apple, dried

- babyfood 0.300000 0.510 1.000 1100010000 11 Apple, juice 0.300000 0.230 1.000 1100010001 11 Apple, juice

- babyfood 0.300000 0.230 1.000 1100011000 11 Apple, sauce 0.3 00000 0.680 1.000 1100011001 11 Apple, sauce

- babyfood 0.300000 0.680 1.000 1100129000 11 Crabapple 0.300000 1.000 1.000 1100210000 11 Loquat 0.300000 1.000 1.000

11 00266000 11 Pear 0.300000 1.000 1.000

1100266001 11 Pear

- babyfood 0.300000 1.000 1.000 1100267000 11 Pear, dried 0.300000 0.510 1.000 1100268000 11 Pear, juice 0.300000 0.870 1.000 1100268001 11 Pear, juice

- babyfood 0.300000 0.870 1.000 1100310000 11 Quince 0.300000 1.000 1.000 1201090000 12A Cherry 0.500000 1.000 1.000 1201090001 12A Cherry

- babyfood 0.500000 1.000 1.000 1201091000 12A Cherry, juice 0.500000 1.500 1.000 1201091001 12A Cherry, juice

- babyfood 0.500000 1.500 1.000 1202012000 12B Apricot 0.500000 1.000 1.000 1202012001 12B Apricot

- babyfood 0.500000 1.000 1.000 1202013000 12B Apricot, dried 0.500000 6.000 1.000 1202014000 12B Apricot, juice 0.500000 1.000 1.000 1202014001 12B Apricot, juice

- babyfood 0.500000 1.000 1.000

1202230000 12B Nectarine 0.500000 1.000 1.000

1202260000 12B Peach 0.500000 1.000 1.000

1202260001 12B Peach

- babyfood 0.500000 1.000 1.000 1202261000 12B Peach, dried 0.500000 3.600 1.000 1202261001 12B Peach, dried

- babyfood 0.500000 3.600 1.000 1202262000 12B Peach, juice 0.500000 1.000 1.000 1202262001 12B Peach, juice

- babyfood 0.500000 1.000 1.000

1203285000 12C Plum 0.050000 1.000 1.00 0

1203285001 12C Plum

- babyfood 0.050000 1.000 1.000 1203286000 12C Plum, prune, fresh 0.050000 1.000 1.000 1203286001 12C Plum, prune, fresh

- babyfood 0.050000 1.000 1.000 1203287000 12C Plum, prune, dried 0.050000 3.100 1.000 1203287001 12C Plum, prune, dried

- babyfood 0.050000 3.100 1.000 1203288000 12C Plum, prune, juice 0.050000 1.400 1.000 1203288001 12C Plum, prune, juice

- babyfood 0.050000 1.400 1.000 2003128000 20C Cottonseed, oil 0.020000 1.000 1.000 2003128001 20C Cottonseed, oil

- babyfood 0.020000 1.000 1.000 3100044000 31 Beef, meat 0.030000 1.000 1.000 3100044001 31 Beef, meat

- babyfood 0.030000 1.000 1.000 3100045000 31 Beef, meat, dried 0.030000 1.920 1.000 3100046000 31 Beef, meat byproducts 0.050000 1.000 1.000

3100046001 31 Beef, meat byproducts

- babyfood 0.050000 1.000 1.000Thiacloprid Dietary Exposure and Risk Assessment DP Number: 405299

Page 12 of 20 3100047000 31 Beef, fat 0.020000 1.000 1.000 3100047001 31 Beef, fat

- babyfood 0.020000 1.000 1.000 3100048000 31 Beef, kidney 0.050000 1.000 1.000 3100049000 31 Beef, liver 0.150000 1.000 1.000 3100049001 31 Beef, liver

- babyfood 0.150000 1.000 1.000 3200169000 32 Goat, meat 0.030000 1.00 0 1.000 3200170000 32 Goat, meat byproducts 0.050000 1.000 1.000 3200171000 32 Goat, fat 0.020000 1.000 1.000 3200172000 32 Goat, kidney 0.050000 1.000 1.000

3200173000 32 Goat, liver 0.150000 1.000 1.000 3300189000 33 Horse, meat 0.030000 1.000 1.000 3500339000 35 Sheep, meat 0.030000 1.000 1.000 3500339001 35 Sheep, meat

- babyfood 0.030000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.050000 1.000 1.000 3500341000 35 Sheep, fat 0.020000 1.000 1.000 3500341001 35 Sheep, fat

- babyfood 0.020000 1. 000 1.000 3500342000 35 Sheep, kidney 0.050000 1.000 1.000 3500343000 35 Sheep, liver 0.150000 1.000 1.000 3600222000 36 Milk, fat 0.030000 1.000 1.000

3600222001 3 6 Milk, fat

- baby food/infant formu 0.030000 1.000 1.000 3600223000 36 Milk, nonfat solids 0.030000 1.000 1.000 3600223001 36 Milk, nonfat solids

- baby food/in 0.030000 1.000 1.000 3600224000 36 Milk, water 0.030000 1.000 1.000 3600224001 36 Milk, water

- babyfood/infant form 0.030000 1.000 1.000 3600225001 36 Milk, sugar (lactose)

- baby food/ 0.030000 1.000 1.000 8601000000 86A Water, di rect, all sources 0.018000 1.000 1.000 8602000000 86B Water, indirect, all sources 0.018000 1.000 1.000Thiacloprid Dietary Exposure and Risk Assessment DP Number: 405299

Page 13 of 20 

### Attachment 2

- Acute Results File

U.S. EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID ACU TE Analysis for THIACLOPRID NHANES 2003

- 2008 2

- Day Residue file: THIACLOPRID ACUTE TOL.R08 Adjustment factor #2 NOT used. Analysis Date: 09

- 28

- 2012/17:07:53 Residue file dated: 09

- 28

- 2012/17:00:42 RAC/FF intake summed over 24 h ours Run Comment: "THIS R98 FILE WAS GENERATED USING THE CONVERT TO R98 UTILITY VER

SION 1.1.2."

===============================================================================

Summary calculations

-- per capita:

95th Percentile 99t h Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- Total US Population:

0.002745 6.24 0.005401 12.28 0.010510 23.89

All Infants:

0.008329 18.93 0.011574 26.30 0.016968 38.56

Children 1

- 2:

0.007996 18.17 0.012617 28.68 0.017068 38.79

Children 3

- 5:

0.005457 12.40 0.008438 19.18 0.012304 27.96

Children 6

- 12:

0.003399 7.72 0.005506 12.51 0.007247 16.47

Youth 13

- 19:

0.001901 4.32 0.002771 6.30 0.00 3752 8.53

Adults 20

- 49:

0.001852 4.21 0.002822 6.41 0.004273 9.71

Adults 50

- 99:

0.001768 4.02 0.002703 6.14 0.004499 10.22

Female 13

- 49:

0.001867 4.24 0.002772 6.30 0.004182 9.51Thiacloprid Dietary Exposure and Risk Assessment DP Number: 405299

Page 14 of 20 

### Attachment 3

– Chronic Residue Input File

Filename: F: \ Thiacloprid \ New dietary \ THIACLOPRID CHRONIC TOL.R08 Chemical: thiacloprid RfD(Chronic): .012 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day
RfD( Acute): .044 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Q*= .0406 Date created/last modified: 09

- 28

- 2012/16:59:08 Program ver. 3.16, 03

- 08

- d

Comment: THIS R98 FILE WAS GENERATED USING THE CONVERT TO R98 UTILITY VERSION 1.1.2.

------------------------ ----------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- --------------------- ---------- ---------- ------ ------ ------- 0802270000 8B Pepper, bell 1.000000 1.000 1.000 0802270001 8B Pepper, bell

- babyfood 1.000000 1.000 1.000 0802271000 8B Pepper, bell, dried 1.00 0000 1.000 1.000 0802271001 8B Pepper, bell, dried

- babyfood 1.000000 1.000 1.000 0802272000 8BC Pepper, nonbell 1.000000 1.000 1.000 0802272001 8BC Pepper, nonbell

- babyfood 1.000000 1.000 1.000

080 2273000 8BC Pepper, nonbell, dried 1.000000 1.000 1.000 1100007000 11 Apple, fruit with peel 0.300000 1.000 1.000 1100008000 11 Apple, peeled fruit 0.300000 0.820 1.000 1100008001 11 Apple, peele d fruit

- babyfood 0.300000 0.820 1.000 1100009000 11 Apple, dried 0.300000 0.510 1.000 1100009001 11 Apple, dried

- babyfood 0.300000 0.510 1.000 1100010000 11 Apple, juice 0. 300000 0.230 1.000 1100010001 11 Apple, juice

- babyfood 0.300000 0.230 1.000 1100011000 11 Apple, sauce 0.300000 0.680 1.000 1100011001 11 Apple, sauce

- babyfood 0.300000 0.680 1.000

1 100129000 11 Crabapple 0.300000 1.000 1.000 1100210000 11 Loquat 0.300000 1.000 1.000

1100266000 11 Pear 0.300000 1.000 1.000

1100266001 11 Pear

- babyf ood 0.300000 1.000 1.000 1100267000 11 Pear, dried 0.300000 0.510 1.000 1100268000 11 Pear, juice 0.300000 0.870 1.000 1100268001 11 Pear, juice

- babyfood 0.300000 0.870 1.000 1100310000 11 Quince 0.300000 1.000 1.000 1201090000 12A Cherry 0.500000 1.000 1.000 1201090001 12A Cherry

- babyfood 0.500000 1.000 1.000 1201091000 12A Cherry, juice 0.500000 1.500 1.000 1201091001 12A Cherry, juice

- babyfood 0.500000 1.500 1.000 1202012000 12B Apricot 0.500000 1.000 1.000

120201200 1 12B Apricot

- babyfood 0.500000 1.000 1.000 1202013000 12B Apricot, dried 0.500000 6.000 1.000 1202014000 12B Apricot, juice 0.500000 1.000 1.000 1202014001 12B Apricot, juice

- bab yfood 0.500000 1.000 1.000

1202230000 12B Nectarine 0.500000 1.000 1.000

1202260000 12B Peach 0.500000 1.000 1.000

1202260001 12B Peach

- babyfood 0.500000 1.000 1.000 1202261000 12B Peach, dried 0.500000 3.600 1.000 1202261001 12B Peach, dried

- babyfood 0.500000 3.600 1.000 1202262000 12B Peach, juice 0.500000 1.000 1.000

1202262 001 12B Peach, juice

- babyfood 0.500000 1.000 1.000

1203285000 12C Plum 0.050000 1.000 1.000

1203285001 12C Plum

- babyfood 0.050000 1.000 1.000 1203286000 12C Plum, prune, fre sh 0.050000 1.000 1.000 1203286001 12C Plum, prune, fresh

- babyfood 0.050000 1.000 1.000 1203287000 12C Plum, prune, dried 0.050000 3.100 1.000 1203287001 12C Plum, prune, dried

- babyfood 0.0500 00 3.100 1.000 1203288000 12C Plum, prune, juice 0.050000 1.400 1.000 1203288001 12C Plum, prune, juice

- babyfood 0.050000 1.400 1.000 2003128000 20C Cottonseed, oil 0.020000 1.000 1.000 2003128001 20C Cottonseed, oil

- babyfood 0.020000 1.000 1.000 3100044000 31 Beef, meat 0.030000 1.000 1.000 3100044001 31 Beef, meat

- babyfood 0.030000 1.000 1.000 3100045000 31 Beef, mea t, dried 0.030000 1.920 1.000 3100046000 31 Beef, meat byproducts 0.050000 1.000 1.000 3100046001 31 Beef, meat byproducts

- babyfood 0.050000 1.000 1.000Thiacloprid Dietary Exposure and Risk Assessment DP Number: 405299

Page 15 of 20 3100047000 31 Beef, fat 0.020000 1.000 1.000 3100047001 31 Beef, fat

- babyfood 0.020000 1.000 1.000 3100048000 31 Beef, kidney 0.050000 1.000 1.000 3100049000 31 Beef, liver 0.150000 1.000 1.000 3100049001 31 Beef, liver

- babyfood 0.150000 1.000 1.000 3200169000 32 Goat, meat 0.030000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.050000 1.000 1.000 3200171000 32 Goat, f at 0.020000 1.000 1.000 3200172000 32 Goat, kidney 0.050000 1.000 1.000 3200173000 32 Goat, liver 0.150000 1.000 1.000 3300189000 33 Horse, meat 0.030000 1.000 1.000 3500339000 35 Sheep, meat 0.030000 1.000 1.000 3500339001 35 Sheep, meat

- babyfood 0.030000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.050000 1.000 1.00 0 3500341000 35 Sheep, fat 0.020000 1.000 1.000 3500341001 35 Sheep, fat

- babyfood 0.020000 1.000 1.000 3500342000 35 Sheep, kidney 0.050000 1.000 1.000 3500343000 35 Sheep , liver 0.150000 1.000 1.000 3600222000 36 Milk, fat 0.030000 1.000 1.000 3600222001 36 Milk, fat

- baby food/infant formu 0.030000 1.000 1.000 3600223000 36 Milk, nonfat solids 0.030000 1.000 1.000 3600223001 36 Milk, nonfat solids

- baby food/in 0.030000 1.000 1.000 3600224000 36 Milk, water 0.030000 1.000 1.000 3600224001 36 Milk, water

- babyfood/infant form 0.030000 1.000 1.000 3600225001 36 Milk, sugar (lactose)

- baby food/ 0.030000 1.000 1.000 8601000000 86A Water, direct, all sources 0.002300 1.000 1.000 8602000000 86B Water, indirect, all sources 0.002300 1.000 1.000Thiacloprid Dietary Exposure and Risk Assessment DP Number: 405299

Page 16 of 20 

### Attachment 4

– Chronic Results File

U.S. EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for THIACLOPRID NHANES 2003

- 2008 2

- day

Residue file name: F: \ Thiacloprid \ New dietary \ THIACLOPRID CHRONIC TO L.R08 Adjustment factor #2 NOT used. Analysis Date 09

- 28

- 2012/17:09:36 Residue file dated: 09

- 28

- 2012/16:59:08 Reference dose (RfD, Chronic) = .012 mg/kg bw/day

COMMENT 1: THIS R98 FILE WAS GENERATED USI NG THE CONVERT TO R98 UTILITY VERSION 1.1.2.

=============================================================================== Total exposure by population subgroup

------------------------------------------------------------------------- ------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.000612 5.1% Hispanic 0.000768 6.4%

Non

- Hisp

- White 0.000596 5.0%

Non

- Hisp

- Black 0.000502 4.2%

Non

- Hisp

- Other 0.000685 5.7% Nursing Infant s 0.001131 9.4%

Non

- Nursing Infants 0.002296 19.1%

Female 13+ PREG 0.000508 4.2%

Children 1

- 6 0.00 2236 18.6%

Children 7

- 12 0.000872 7.3%

Male 13

- 19 0.000454 3.8%

Female 13

- 19/NP 0.000434 3.6%

Male 20+ 0.000387 3.2% Female 20+/NP 0.000397 3.3%

Seniors 55+ 0.000422 3.5%

All Infants 0.001936 16.1%

Female 13

- 50 0.000389 3.2%

Children 1

- 2 0.003106 25.9%

Children 3

- 5 0.001859 15.5%

Ch ildren 6

- 12 0.000961 8.0%

Youth 13

- 19 0.000444 3.7%

Adults 20

- 49 0.000380 3.2%

Adults 50

- 99 0.000414 3.5%

Female 13

- 49 0.000388 3.2%

-------------------------------------------------------------------------------Thiacloprid Dietary Exposure and Risk Assessment DP Number: 405299

Page 17 of 20 

### Attachment 5

- Cancer Residue Input File

Filename: F: \ Thiacloprid \ New dietary \ THIACLOPRID CANCER.R08 Chemical: thiacloprid RfD(Chronic): .012 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .044 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Q*= .0406 Date created/last modified: 10

- 16

- 2012/14:24:49 Program ver. 3.16, 03

- 08

- d

Comment: THIS R98 FILE WAS GENERATED USING THE CONVERT TO R98 UTILITY VERSION 1.1.2.

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0802270000 8B Pepper, bell 0.053000 1.000 0 .450 Non

- be

Full comment: Non

- bell pepper FT avg, avg %CT 0802270001 8B Pepper, bell

- babyfood 0.053000 1.000 0.450 0802271000 8B Pepper, bell, dried 0.053000 1.000 0.450 0802271001 8B Pepper, bell, d ried

- babyfood 0.053000 1.000 0.450 0802272000 8BC Pepper, nonbell 0.077000 1.000 0.450 Bell p

Full comment: Bell pepper FT avg., avg. %CT 0802272001 8BC Pepper, nonbell

- babyfood 0.077000 1.000 0. 450 0802273000 8BC Pepper, nonbell, dried 0.077000 1.000 0.450 1100007000 11 Apple, fruit with peel 0.066000 1.000 0.100 Apple

Full comment: Apple FT avg., avg %CT 1100008000 11 Apple, peeled fruit 0.066000 0.820 0.100 1100008001 11 Apple, peeled fruit

- babyfood 0.066000 0.820 0.100 1100009000 11 Apple, dried 0.066000 0.510 0.100 1100009001 11 Apple, dried

- babyfood 0.066000 0.51 0 0.100 1100010000 11 Apple, juice 0.066000 0.230 0.100 1100010001 11 Apple, juice

- babyfood 0.066000 0.230 0.100 1100011000 11 Apple, sauce 0.066000 0.680 0.100

1100011001 11 Apple, sauce

- babyfood 0.066000 0.680 0.100 1100129000 11 Crabapple 0.066000 1.000 1.000 Transl

Full comment: Translated Apple FT average 1100210000 11 Loquat 0.141 000 1.000 1.000 Transl

Full comment: Translated Pear FT average

1100266000 11 Pear 0.141000 1.000 0.050 Pear F

Full comment: Pear FT average, avg %CT

1100266001 11 Pear

- babyfood 0.141000 1.000 0.050 1100267000 11 Pear, dried 0.141000 0.510 0.050 1100268000 11 Pear, juice 0.141000 0.870 0.050 1100268001 11 Pear, juice

- babyfood 0.141000 0.870 0.050 1100310000 11 Quince 0.141000 1.000 1.000 Transl

Full comment: Translated pear FT average 1201090000 12A Cherry 0.162000 1.000 1.000 Cherry

Full comment: C herry FT avg. 1201090001 12A Cherry

- babyfood 0.162000 1.000 1.000 1201091000 12A Cherry, juice 0.162000 1.500 1.000 1201091001 12A Cherry, juice

- babyfood 0.162000 1.500 1.000

1202012000 12B Apricot 0.167000 1.000 1.000 Transl

Full comment: Translated Peach FT avg. 1202012001 12B Apricot

- babyfood 0.167000 1.000 1.000 1202013000 12B Apricot, dried 0.1 67000 6.000 1.000 1202014000 12B Apricot, juice 0.167000 1.000 1.000 1202014001 12B Apricot, juice

- babyfood 0.167000 1.000 1.000

1202230000 12B Nectarine 0.167000 1.000 1.000 Tra nsl

Full comment: Translated Peach FT avg.

1202260000 12B Peach 0.167000 1.000 0.430 Peach

Full comment: Peach FT avg., avg. %CT

1202260001 12B Peach

- babyfood 0.167000 1.000 0.430 1202261000 12B Peach, dried 0.167000 3.600 0.430 1202261001 12B Peach, dried

- babyfood 0.167000 3.600 0.430 1202262000 12B Peach, juice 0.16 7000 1.000 0.430 1202262001 12B Peach, juice

- babyfood 0.167000 1.000 0.430

1203285000 12C Plum 0.016000 1.000 1.000 Plum F

Full comment: Plum FT avg.

1203285001 12C Plum

- babyfood 0.016000 1.000 1.000 1203286000 12C Plum, prune, fresh 0.016000 1.000 1.000Thiacloprid Dietary Exposure and Risk Assessment DP Number: 405299

Page 18 of 20 1203286001 12C Plum, prune, fresh

- babyfood 0.016000 1.000 1.000 1203287000 12C Plum, prune, dried 0.016000 3.100 1.000 1203287001 12C Plum, prune, dried

- babyfood 0.016000 3.100 1.000 1203288000 12C Plum, prune, juice 0.016000 1.400 1.000 1203288001 12C Plum, prune, juice

- babyfood 0.016000 1.400 1.000

2003128 000 20C Cottonseed, oil 0.020000 1.000 1.000 Tolera

Full comment: Tolerance level residue for cottonseed 2003128001 20C Cottonseed, oil

- babyfood 0.020000 1.000 1.000 3100044000 31 Beef, meat 0.000100 1.000 1.000 3100044001 31 Beef, meat

- babyfood 0.000100 1.000 1.000 3100045000 31 Beef, meat, dried 0.000100 1.920 1.000 3100046000 31 Beef, meat byproducts 0.000600 1 .000 1.000 3100046001 31 Beef, meat byproducts

- babyfood 0.000600 1.000 1.000 3100047000 31 Beef, fat 0.000100 1.000 1.000 3100047001 31 Beef, fat

- babyfood 0.000100 1.000 1.000

3100048000 31 Beef, kidney 0.000200 1.000 1.000 3100049000 31 Beef, liver 0.000600 1.000 1.000 3100049001 31 Beef, liver

- babyfood 0.000600 1.000 1.000 3200169000 32 Goat, meat 0.000100 1.000 1.000 3200170000 32 Goat, meat byproducts 0.000600 1.000 1.000 3200171000 32 Goat, fat 0.000100 1.000 1.000 3200172000 32 Goat, kid ney 0.000200 1.000 1.000 3200173000 32 Goat, liver 0.000600 1.000 1.000 3300189000 33 Horse, meat 0.000100 1.000 1.000 3500339000 35 Sheep, meat 0.000100 1.000 1.000 3500339001 35 Sheep, meat

- babyfood 0.000100 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.000600 1.000 1.000 3500341000 35 Sheep, fat 0.000100 1.000 1.000 3500341001 35 Sheep, fat

- babyfood 0.000100 1.000 1.000 3500342000 35 Sheep, kidney 0.000200 1.000 1.000 3500343000 35 Sheep, liver 0.000600 1.000 1.000 3600222000 36 Milk, f at 0.000100 1.000 1.000 3600222001 36 Milk, fat

- baby food/infant formu 0.000100 1.000 1.000 3600223000 36 Milk, nonfat solids 0.000100 1.000 1.000 3600223001 36 Milk, nonfat solids

- baby food/in 0.000100 1.000 1.000 3600224000 36 Milk, water 0.000100 1.000 1.000 3600224001 36 Milk, water

- babyfood/infant form 0.000100 1.000 1.000 3600225001 36 Milk, sugar (lactose)

- baby food/ 0.000100 1.000 1.00 0 8601000000 86A Water, direct, all sources 0.001200 1.000 1.000 8602000000 86B Water, indirect, all sources 0.001200 1.000 1.000Thiacloprid Dietary Exposure and Risk Assessment DP Number: 405299

Page 19 of 20 

### Attachment 6

– Cancer Results File

A. Food + Drinking Water

U.S. EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for THIACLOPRID NHANES 2003

- 2008 2

- day

Residue file name: F: \ Thiacloprid \ New dietary \ THIACLOPRID CANCER.R08 Adjust ment factor #2 used. Analysis Date 10

- 16

- 2012/14:25:22 Residue file dated: 10

- 16

- 2012/14:24:49
Q* = 0.0406

COMMENT 1: THIS R98 FILE WAS GENERATED USING THE CONVERT TO R98 UTILITY VERSION 1.1.2.

========================================================= ====================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Lifetime risk Subgroup body wt/day (Q*= .0406)

-------------------------------------- ------------- -- ------------ Total US Population 0.000049 1.99E

- 06



### B. Food Only

U.S. EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for THIACLOPRID NHANES 2003

- 2008 2

- day

Residue file name: F: \ Thiacloprid \ New dietary \ THIACLOPRID CANCER No DW.R08 Adjustment factor #2 used. Analysis Date 10

- 16

- 2012/14:47:54 Residue file dated: 10

- 16

- 2012/14:47:14
Q* = 0.0406

COMMENT 1: THIS R98 FILE WAS GENERATED USING THE CONVERT TO R98 UTILITY VERSION 1.1.2.

=============================================================================== Total exposure by population subgroup

------------------------------- ------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Lif etime risk Subgroup body wt/day (Q*= .0406)

-------------------------------------- ------------- -------------- Total US Population 0.000024 9.68E

- 07Thiacloprid Dietary Exposure and Risk Assessment DP Number: 405299

Page 20 of 20 

### Attachment 7

– BEAD PCT and PCTn Data

A. New Uses on Stone Fruit and Peppers

– PCTn Data (From BEAD Memo J. Alsadek, D382568, 09

- 26

- 2012)

B. Existing Uses (From BEAD SLUA, J. Alsadek

, 04

- Oct

- 2012 )

October 4, 2012

Screening Level Estimates of Agricultural Uses of Thiacloprid ( 014019 ) Sorted Alphabetically Reporting Years: 200 4

- 201 1

Percent Crop T reated Crop Lbs. A.I. Avg. Max.

1 Apples 10,000 10 20



### 2 Pears 1,000 5 10

All numbers are rounded.

SLUA data sources include:

USDA

- NASS (United States Department of Agriculture's National Agricultural Statistics Service)
Private Pesticide Market Research These results reflect amalgamated data developed by the Agency and are releasable to the public.