Exhibit 10.4

[*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted
portions.

Addendum No. 3 to the Master Supply Agreement Dated as of April 1, 2009

This Addendum No. 3 to the Master Supply Agreement dated as of April 1, 2009 (the Third Addendum) is effective as
of April 1, 2011 (the Third Addendum Effective Date), by and between diaDexus, Inc. (diaDexus), and Berkeley HeartLab, Inc. (Lab).

WHEREAS, Lab and diaDexus are parties to that certain Master Supply Agreement dated April 1, 2009, as amended by Addendum No. 1 dated as of April 1, 2010 and Addendum No. 2 dated as of
May 14, 2010 (collectively, the Agreement);

WHEREAS, the parties desire to amend such Agreement to extend
the term of the Agreement.

NOW THEREFORE, in consideration of the agreements, mutual representations and covenants contained
herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereby agree as follows:

1. Definitions. All capitalized terms not defined herein shall have the meaning assigned to them in the Agreement.

2. Term. The first sentence of Section C of the Agreement is hereby deleted in its entirety and replaced with the following:

The term of the Agreement shall commence on April 1, 2009 and expire on [*](the Term), unless terminated earlier
pursuant to Paragraph N or P.

3. Entire Agreement. In the event of any conflict between the terms and conditions of
this Third Addendum and the Agreement, the terms and conditions of this Third Addendum shall control. Except as otherwise provided in the Third Addendum, the parties agree that all provisions of the Agreement are hereby ratified and agreed to be in
full force and effect and are incorporated herein by reference. This Third Addendum and the Agreement (as amended hereby), including without limitation all Attachments hereto, contain the entire agreement among the parties relating to the subject
matter herein and all prior proposals, discussions and writings by and among the parties and relating to the subject matter herein, whether written or oral, are superseded hereby and thereby. None of the terms of this Third Addendum shall be deemed
to be amended unless such amendment is in writing, signed by all parties hereto, and recites specifically that it is an addendum to the terms of this Third Addendum.

IN WITNESS WHEREOF, the parties hereto have caused this Third Addendum to be executed by their fully authorized representatives.



|                        |  |  |  |                             
|----------------------- |  |  |  | ----------------------------
|diaDexus, Inc.:         |  |  |  | Berkeley HeartLab, Inc.:    
|                        |  | 
|By: /s/ Patrick Plewman |  |  |  | By: /s/ Michael Mercer      
|                        |  | 
|Name: Patrick Plewman   |  |  |  | Name: Michael Mercer        
|                        |  | 
|Title: CEO              |  |  |  | Title: Senior Vice President
|                        |  | 
|Date: 4/8/11            |  |  |  | Date: Apr 7, 2011           



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