Fluoxastrobin 028869 Dietary Exposure and Risk Assessment DP Number: 380847

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF CHEMICAL SAFETY 

 AND POLLUTION PREVENTION

MEMORANDUM

DATE: 12/28/2010 

SUBJECT: Fluoxastrobin: Chronic Dietary (Food and Drinking Water) Exposure 

Assessments for the Section 3 Registration Action use on 

Squash/Cucumber Subgroup 9B.

PC Code: 028869 DP Barcode: 380847

Decision No.: 433137 Registration No.: 66330-64

Petition No.: NA Regulatory Action: Section 3 Registration

Risk Assessment Type: Dietary Case No.: NA

TXR No.: NA CAS No.: 361377-29-9

MRID No.: NA 40 CFR: §180.609

REVIEWER: Cassi L. Walls, Ph.D, Senior Biologist

Risk Assessment Branch III

Health Effects Division (7509P)

THROUGH: Mohsen Sahafeyan, Chemist

Donna Davis, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division (7509P)

TO: Nancy Tsaur, Risk Assessor

Risk Assessment Branch III

Health Effects Division (7509P)

Tony Kish, RM Team #22

Registration Division (7505P)

Executive Summary

Chronic dietary (food and drinking water) exposure and risk assessments were conducted 

using the Dietary Exposure Evaluation Model (DEEM-FCIDTM, Version 2.03), which 

uses food consumption data from the U.S. Department of Agriculture’s Continuing 

Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 1998. The analyses

were performed to support new uses on crop subgroup 9B.
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Acute Dietary Exposure Results and Characterization: 

No toxic effects attributable to a single exposure to fluoxastrobin have been identified; 

therefore, an acute reference dose (aRfD) has not been established and an acute dietary

exposure assessment was not conducted. 

 

Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization

A conservative dietary exposure assessment was performed for fluoxastrobin. The 

assumptions of this dietary assessment included tolerance level residues and 100% crop 

treated (CT). Estimated drinking water concentration (EDWC) values were also 

incorporated. The estimated surface water concentration was incorporated directly into 

the dietary assessment using the 1-in-10 yr annual mean of 53 μg/L (DP379114, 384377). 

The results of the chronic dietary analysis for food and drinking water are below the 

Agency’s level of concern for all population subgroups. The dietary exposure for food 

and water is estimated at 22% of the chronic Population Adjusted Dose (cPAD) for the 

general U.S. population and 47%, of the cPAD for children 1-2 yrs, the population 

subgroup with the highest estimated chronic dietary exposure to fluoxastrobin.

Cancer Dietary Exposure Results and Characterization

The Cancer Assessment Review Committee (CARC) recently concluded that 

fluoxastrobin is “not likely to be carcinogenic to humans;” therefore, cancer risk is not of 

concern. 

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For 

acute and chronic assessments, the risk is expressed as a percentage of a maximum 

acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable 

adverse health effects). This dose is referred to as the population adjusted dose (PAD). 

The PAD is equivalent to the reference dose point of departure (POD, NOAEL, LOAEL) 

divided by the required uncertainty and safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary

risk exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk 

exceeds one in one million. References which discuss the acute and chronic risk 

assessments in more detail are available on the EPA/pesticides web site: “Available 

Information on Assessing Exposure from Pesticides, A User’s Guide,” 6/21/2000, web 

link: http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 

99.6 (8/20/99).

The last dietary risk assessment for fluoxastrobin was conducted by M. Negussie

(01/22/2010, DP367050). This dietary assessment is an update to the January 2010
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fluoxastrobin dietary assessment to include the proposed new uses on squash/cucumber 

Subgroup 9B.

II. Residue Information

Fluoxastrobin is a fungicide used for the control of fungal diseases in tuberous and corm 

vegetables, fruiting vegetables, the leaf petiole vegetables, peanuts, sweet corn, wheat, as 

a seed treatment for potato and peanut, and as a soilborne/seedling disease control. 

The residues of concern in primary crops, rotational crops, and livestock, for tolerance 

enforcement and risk assessment are as follows: primary crops/rotational crops 

fluoxastrobin and its Z-isomer, livestock- fluoxastrobin, its Z-isomer and 6-(2-

chlorophenoxy)-5-fluoro-4-pyrimidinol ( DP289106, W. Wassell, 01/25/2005). Table 1 

is a summary of the current food tolerances, Table 2 is a summary of pending tolerances, 

and Table 3 is a summary of the proposed tolerances for fluoxastrobin.

As stated above, Arysta is requesting the establishment of tolerances for fluoxastrobin for 

the new use on squash/cucumber Subgroup 9B. HED recommends a food tolerance 0.50 

ppm for residues of fluoxastrobin resulting from the proposed new use on 

squash/cucumbers (DP380846, M. Negussie, 11/17/2010). 

TABLE 1. Summary of Current Tolerances for Fluoxastrobin

Commodity Tolerance (ppm)

40 CFR §180.609(a)(1)

Berry, low growing, subgroup 13-07G 1.9

Leaf petioles, subgroup 4B 4.0

Soybean seed 0.05

Tomato paste 1.5

Vegetable, fruiting, group 8 1.0

Vegetable, tuberous and corm, subgroup 

1C

0.01

40 CFR §180.609(a)(2)

Cattle, fat

Goat, fat

Horse, fat

Sheep, fat

0.10

Cattle, meat

Goat, meat

Horse, meat

Sheep, meat

0.05

Milk 0.02

Milk, fat 0.50
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TABLE 2. Summary of Pending Tolerance for Fluoxastrobin

Commodity Tolerance (ppm)

40 CFR §180.609(a)(1)

Corn, sweet, kernels plus cobs with 

husks removed (K+CWHR)

0.01

Wheat, grain 0.09

Wheat, bran 0.15

Peanut* 0.02

Peanut, refined oil* 0.06

40 CFR §180.609(a)(2)

Cattle, meat byproducts*

Goat, meat byproducts

Horse, meat byproducts

Sheep, meat byproducts

0.20

* Note that the current 40 CFR §180.609(a)(1) and (2) lists different tolerances for these commodities. 

The tolerances listed in this table differ because the registrant provided additional data and requested 

tolerances for new uses that can be fed to livestock which affected the livestock commodity residues. 

These tolerances are still pending. Detailed information on these data can be found in the previous dietary 

assessment (DP367050, M. Negussie, 01/22/2010).

TABLE 3. Summary of Proposed Tolerance for Fluoxastrobin

Commodity Tolerance (ppm)

40 CFR §180.609(a)(1)

Squash/cucumber Subgroup 9B 0.50

Residue Data used for Chronic Assessments:

Current, pending, and proposed tolerance level residues and 100% CT were used for all 

commodities included in the assessment. Based on processing studies, the processing 

factors for tomato puree, potato, chips, dried potato (granules/flakes), and potato, flour

were reduced to 1. Separate tolerances were set for peanut oil, wheat bran and tomato 

paste; therefore, the processing factors for these commodities were set at 1 (DP289106, 

W.D. Wassell, 01/25/2005). For all other processed commodities, DEEM version 7.81

default processing factors were assumed. 

Residue values used for chronic assessments are listed in Tables 1, 2, and 3 while the 

processing factors are listed in Table 4.

TABLE 4. Processing Factors (PF) for Fluoxastrobin Dietary Risk Assessment.

Processed Commodity PF Source

Beef, meat, dried 1.92 DEEM Default

Corn grain, sugar/hfcs 1.5 DEEM Default

Cranberries, juice 1.1 DEEM Default

Peanut, butter 1.89 DEEM Default

Peanut, oil 1.0 Tolerance for peanut, oil 

accounts for processing.
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TABLE 4. Processing Factors (PF) for Fluoxastrobin Dietary Risk Assessment.

Potato, dried and flour 1.0 Processing Study

Tomato, dried 14.3 DEEM Default

Tomato, juice 1.5 DEEM Default

Tomato, paste 1.0 Tolerance for tomato, paste 

accounts for processing.

Tomato, puree 1.0 Processing Study

Wheat, bran 1.0 Tolerance for wheat, bran 

accounts for processing.

III. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED) (DP379114 and 384377, R. Bohaty, 

12/15/10) and incorporated directly into this dietary assessment. Water residues were 

incorporated in the DEEM-FCID into the food categories “water, direct, all sources” and 

“water, indirect, all sources.”

Tier II EDWCs in surface water were estimated using PRZM/EXAMS while Tier I 

EDWCs in groundwater were estimated using the SCI-GROW Model. The chronic Tier 

II EDWCs for the new use on squash/cucumbers are significantly lower (12 μg/L) than 

the exposures calculated based on the revised existing fluoxastrobin use on turf (53 

μg/L). The revised turf use provided the most conservative EDWC and was used in this 

assessment. 

Fluoxastrobin EDWCs were estimated using the turf use based on an application interval of 7 days

and total application rate of 2.2 lb ai/A resulting from 4 applications of 0.55 lb ai/A. The currently

approved label and the proposed label for fluoxastrobin allow for a 7 day application interval on 

turf. Table 5 provides an updated Tier II EDWCs for turf in surface water. In the chronic analysis, 

the 1- in 10 year peak surface water value of 53 ppb was used. The models and their descriptions 

are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/. 

TABLE 5. Tier II EDWCs of Fluoxastrobin in surface water.

Crop Scenario

PRZM/EXAMS Estimated Concentrations in Surface Water (μg/L)

1-in-10 year Annual 

Peak (Acute)

1-in-10 year Annual 

Mean (Chronic)

30 year annual 

mean

(Cancer)

Turf use 60.7 52.9 23.5

IV. DEEM-FCIDTM Program and Consumption Information

Fluoxastrobin chronic dietary exposure assessments were conducted using the Dietary

Exposure Evaluation Model software with the Food Commodity Intake Database 

(DEEM-FCIDTM, Version 2.03), which incorporates consumption data from USDA’s 

Continuing Surveys of Food Intakes by Individuals (CSFII), 1994-1996 and 1998. The 
Fluoxastrobin 028869 Dietary Exposure and Risk Assessment DP Number: 380847

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1994-96, 98 data are based on the reported consumption of more than 20,000 individuals 

over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked 

to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation 

files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, 

consumption data are averaged for the entire U.S. population and within population 

subgroups, but for acute exposure assessment are retained as individual consumption 

events. Based on analysis of the 1994-96, 98 CSFII consumption data, which took into 

account dietary patterns and survey respondents, HED concluded that it is most 

appropriate to report risk for the following population subgroups: the general U.S. 

population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-

19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or 

food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied 

by the average daily consumption estimate for that food/food form to produce a residue 

intake estimate. The resulting residue intake estimate for each food/food form is summed 

with the residue intake estimates for all other food/food forms on the commodity residue 

list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg 

body weight/day and as a percent of the cPAD. This procedure is performed for each 

population subgroup.

V. Toxicological Information

The toxicity endpoints pertinent for human dietary risk assessment are summarized in 

Table 6. 

TABLE 6. Summary of Toxicological Doses and Endpoints for Fluoxastrobin for Use in Dietary 

Exposure Risk Assessments

Exposure/

Scenario

Dose Used in Risk 

Assessment, UF

FQPA SF and 

Endpoint for Risk 

Assessment

Study and Toxicological 

Effects

Acute Dietary 

(General Population) No acute endpoint was identified for the general population.

Acute Dietary

(Females 13-49 

years of age) No acute endpoint was identified for females 13 to 49 years old.

Chronic Dietary all 

Populations

NOAEL = 1.5 

mg/kg/day

UF = 100

Chronic RfD = 

0.015 mg/kg/day

FQPA SF = 1X

cPAD = chronic RfD

 FQPA SF

= 0.015 mg/kg/day

Chronic toxicity study with 

dogs.

LOAEL = M/F:8.1/7.7 

mg/kg/day based on body 

weight reductions and 

hepatocytomegaly and 

cytoplasmic changes associated 

with increased serum liver 

alkaline phosphatase indicative 

of cholestasis. 

Cancer (oral, 

dermal, inhalation) 

Classification: Not likely to be carcinogenic to humans.
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NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF =

uncertainity factor. FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = 

chronic). RfD = reference dose. 

VI. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk 

exceeds 100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure 

of the U.S. population and various population subgroups. The results reported in Table 7

are for the general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, 

children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+ years. 

Results of Chronic Dietary Exposure Analysis

The results of the aggregate chronic dietary analysis for food and drinking water are 

below the Agency’s level of concern (<100% cPAD) for the general U.S. population 

(19% cPAD) and all population subgroups. The most highly exposed population 

subgroup is children 1-2 yrs at 47% of the cPAD. The results of the chronic dietary

exposure analyses are reported in Table 7 below.

Table 7. Result of Acute and Chronic Dietary Exposure and Risk Estimates for Fluoxastrobin

Population Subgroup PAD, 

mg/kg/day

DEEM-FCID (food only) DEEM-FCID (food and water)

Exposure, 

mg/kg/day % PAD Exposure, mg/kg/day %PAD

Chronic Dietary Estimates

U.S. Population

0.015

0.002154 14 0.003269 22

All infants (< 1 yr) 0.001470 9.8 0.005125 34

Children 1-2 yrs 0.005323 36 0.006979 47

Children 3-5 yrs 0.004553 30 0.006103 41

Children 6-12 yrs 0.003055 20 0.004125 28

Youth 13-19 yrs 0.001914 13 0.002720 18

Adults 20-49 yrs 0.001780 12 0.002821 19

Adults 50+ yrs 0.001749 12 0.002844 19

Females 13-49 yrs 0.001728 12 0.002765 18

Cancer Dietary Exposure Results and Characterization

As noted above, the HED CARC has recently revisited the cancer classification for 

fluoxastrobin. HED has reclassified fluoxastrobin as “not likely to be carcinogenic to 

humans,” therefore cancer risk is not of concern. 

VIII. Characterization of Inputs/Outputs

The chronic dietary risk assessment is conservative. For this assessment, tolerance level 

residues and 100% CT were incorporated in the dietary analyses. Based on processing 
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studies, the processing factors for tomato puree, potato, chips, dried potato 

(granules/flakes), and potato, flour were reduced to 1. Separate tolerances were set for 

peanut oil, wheat bran and tomato paste; therefore, the processing factors for these 

commodities were set at 1. For all other processed commodities, DEEM version 7.81

default processing factors were assumed. The assessment can be refined using percent 

crop treated information and monitoring data, however, since there are no risks of 

concern, additional refinement was not required.

Estimated drinking water concentrations for surface water were also incorporated. The

contribution of residues in drinking water to the dietary risk is minimal. 

IX. Conclusions

Dietary risks for fluoxastrobin are below HED’s level of concern for dietary exposure 

and risk. Children 1-2 years old are the most highly exposed population subgroup for 

chronic exposure, with risks estimates at 47% of the cPAD. Risks were lower for all 

other population subgroups, including the general U.S. population which has a %cPAD. 

of 22%. The chronic dietary exposure assessment is not likely to underestimate 

exposure.

 

X. List of Attachments

Attachment 1. Fluoxastrobin Chronic Dietary Analysis Input File - Food & Water

Attachment 2. Fluoxastrobin Chronic Dietary Analysis Results - Food & Water

Attachment 3. Fluoxastrobin Chronic Dietary Analysis Results - Food only
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Filename: C:\Documents and Settings\cwalls\My 

Documents\Cassi\HED\Fluoxastrobin\Fluoxastrobin_tol+water_121510.R98

Chemical: Fluoxastrobin

RfD(Chronic): .015 mg/kg bw/day NOEL(Chronic): 1.5 mg/kg bw/day

RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 12-16-2010/15:27:05/8 Program ver. 2.03

Comment: proposed squash/cucumber use, new EDWC

-------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors 

Comment

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -----

01030150 1CD Arrowroot, flour 0.010000 1.000 1.000 

01030151 1CD Arrowroot, flour-babyfood 0.010000 1.000 1.000 

01030170 1CD Artichoke, Jerusalem 0.010000 1.000 1.000 

01030820 1CD Cassava 0.010000 1.000 1.000 

01030821 1CD Cassava-babyfood 0.010000 1.000 1.000 

01031390 1CD Dasheen, corm 0.010000 1.000 1.000 

01031660 1CD Ginger 0.010000 1.000 1.000 

01031661 1CD Ginger-babyfood 0.010000 1.000 1.000 

01031670 1CD Ginger, dried 0.010000 1.000 1.000 

01032960 1C Potato, chips 0.010000 1.000 1.000 

01032970 1C Potato, dry (granules/ flakes) 0.010000 1.000 1.000 

01032971 1C Potato, dry (granules/ flakes)-b 0.010000 1.000 1.000 

01032980 1C Potato, flour 0.010000 1.000 1.000 

01032981 1C Potato, flour-babyfood 0.010000 1.000 1.000 

01032990 1C Potato, tuber, w/peel 0.010000 1.000 1.000 

01032991 1C Potato, tuber, w/peel-babyfood 0.010000 1.000 1.000 

01033000 1C Potato, tuber, w/o peel 0.010000 1.000 1.000 

01033001 1C Potato, tuber, w/o peel-babyfood 0.010000 1.000 1.000 

01033660 1CD Sweet potato 0.010000 1.000 1.000 

01033661 1CD Sweet potato-babyfood 0.010000 1.000 1.000 

01033710 1CD Tanier, corm 0.010000 1.000 1.000 

01033870 1CD Turmeric 0.010000 1.000 1.000 

01034060 1CD Yam, true 0.010000 1.000 1.000 

01034070 1CD Yam bean 0.010000 1.000 1.000 

04020760 4B Cardoon 4.000000 1.000 1.000 

04020850 4B Celery 4.000000 1.000 1.000 

04020851 4B Celery-babyfood 4.000000 1.000 1.000 

04020860 4B Celery, juice 4.000000 1.000 1.000 

04020870 4B Celtuce 4.000000 1.000 1.000 

04021520 4B Fennel, Florence 4.000000 1.000 1.000 

04023220 4B Rhubarb 4.000000 1.000 1.000 

04023670 4B Swiss chard 4.000000 1.000 1.000 

06003470 6 Soybean, seed 0.050000 1.000 1.000 

06003480 6 Soybean, flour 0.050000 1.000 1.000 

06003481 6 Soybean, flour-babyfood 0.050000 1.000 1.000 

06003490 6 Soybean, soy milk 0.050000 1.000 1.000 

06003491 6 Soybean, soy milk-babyfood or in 0.050000 1.000 1.000 

06003500 6 Soybean, oil 0.050000 1.000 1.000 

06003501 6 Soybean, oil-babyfood 0.050000 1.000 1.000 

08001480 8 Eggplant 1.000000 1.000 1.000 

08002340 8 Okra 1.000000 1.000 1.000 

08002700 8 Pepper, bell 1.000000 1.000 1.000 

08002701 8 Pepper, bell-babyfood 1.000000 1.000 1.000 

08002710 8 Pepper, bell, dried 1.000000 1.000 1.000 

08002711 8 Pepper, bell, dried-babyfood 1.000000 1.000 1.000 

08002720 8 Pepper, nonbell 1.000000 1.000 1.000 

08002721 8 Pepper, nonbell-babyfood 1.000000 1.000 1.000 

08002730 8 Pepper, nonbell, dried 1.000000 1.000 1.000 

08003740 8 Tomatillo 1.000000 1.000 1.000 

08003750 8 Tomato 1.000000 1.000 1.000 

08003751 8 Tomato-babyfood 1.000000 1.000 1.000 
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08003760 8 Tomato, paste 1.500000 1.000 1.000 

08003761 8 Tomato, paste-babyfood 1.500000 1.000 1.000 

08003770 8 Tomato, puree 1.000000 1.000 1.000 

08003771 8 Tomato, puree-babyfood 1.000000 1.000 1.000 

08003780 8 Tomato, dried 1.000000 14.300 1.000 

08003781 8 Tomato, dried-babyfood 1.000000 14.300 1.000 

08003790 8 Tomato, juice 1.000000 1.500 1.000 

09020210 9B Balsam pear 0.500000 1.000 1.000 

09020880 9B Chayote, fruit 0.500000 1.000 1.000 

09021020 9B Chinese waxgourd 0.500000 1.000 1.000 

09021350 9B Cucumber 0.500000 1.000 1.000 

09023080 9B Pumpkin 0.500000 1.000 1.000 

09023090 9B Pumpkin, seed 0.500000 1.000 1.000 

09023560 9B Squash, summer 0.500000 1.000 1.000 

09023561 9B Squash, summer-babyfood 0.500000 1.000 1.000 

09023570 9B Squash, winter 0.500000 1.000 1.000 

09023571 9B Squash, winter-babyfood 0.500000 1.000 1.000 

13020570 13B Blueberry 1.900000 1.000 1.000 

13020571 13B Blueberry-babyfood 1.900000 1.000 1.000 

15001200 15 Corn, field, flour 0.020000 1.000 1.000 

15001201 15 Corn, field, flour-babyfood 0.020000 1.000 1.000 

15001210 15 Corn, field, meal 0.020000 1.000 1.000 

15001211 15 Corn, field, meal-babyfood 0.020000 1.000 1.000 

15001220 15 Corn, field, bran 0.020000 1.000 1.000 

15001230 15 Corn, field, starch 0.020000 1.000 1.000 

15001231 15 Corn, field, starch-babyfood 0.020000 1.000 1.000 

15001240 15 Corn, field, syrup 0.020000 1.500 1.000 

15001241 15 Corn, field, syrup-babyfood 0.020000 1.500 1.000 

15001250 15 Corn, field, oil 0.020000 1.000 1.000 

15001251 15 Corn, field, oil-babyfood 0.020000 1.000 1.000 

15001270 15 Corn, sweet 0.010000 1.000 1.000 

DP#364

 Full comment: DP#364445

15001271 15 Corn, sweet-babyfood 0.010000 1.000 1.000 

15004010 15 Wheat, grain 0.090000 1.000 1.000 

DP#364

 Full comment: DP#364445

15004011 15 Wheat, grain-babyfood 0.090000 1.000 1.000 

DP#364

 Full comment: DP#364445

15004020 15 Wheat, flour 0.090000 1.000 1.000 

DP#364

 Full comment: DP#364445

15004021 15 Wheat, flour-babyfood 0.090000 1.000 1.000 

DP#364

 Full comment: DP#364445

15004030 15 Wheat, germ 0.090000 1.000 1.000 

DP#364

 Full comment: DP#364445

15004040 15 Wheat, bran 0.150000 1.000 1.000 

DP#364

 Full comment: DP#364445

21000440 M Beef, meat 0.050000 1.000 1.000 

21000441 M Beef, meat-babyfood 0.050000 1.000 1.000 

21000450 M Beef, meat, dried 0.050000 1.920 1.000 

21000460 M Beef, meat byproducts 0.200000 1.000 1.000 

DP#364

 Full comment: DP#364445

21000461 M Beef, meat byproducts-babyfood 0.200000 1.000 1.000 

21000470 M Beef, fat 0.100000 1.000 1.000 

21000471 M Beef,fat-babyfood 0.100000 1.000 1.000 

21000480 M Beef, kidney 0.200000 1.000 1.000 

DP#364
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 Full comment: DP#364445

21000490 M Beef, liver 0.200000 1.000 1.000 

DP#364

 Full comment: DP#364445

21000491 M Beef, liver-babyfood 0.200000 1.000 1.000 

23001690 M Goat, meat 0.050000 1.000 1.000 

23001700 M Goat, meat byproducts 0.200000 1.000 1.000 

DP#364

 Full comment: DP#364445

23001710 M Goat, fat 0.100000 1.000 1.000 

23001720 M Goat, kidney 0.200000 1.000 1.000 

DP#364

 Full comment: DP#364445

23001730 M Goat, liver 0.200000 1.000 1.000 

DP#364

 Full comment: DP#364445

24001890 M Horse, meat 0.050000 1.000 1.000 

26003390 M Sheep, meat 0.050000 1.000 1.000 

26003391 M Sheep, meat-babyfood 0.050000 1.000 1.000 

26003400 M Sheep, meat byproducts 0.200000 1.000 1.000 

DP#364

 Full comment: DP#364445

26003410 M Sheep, fat 0.100000 1.000 1.000 

26003411 M Sheep, fat-babyfood 0.100000 1.000 1.000 

26003420 M Sheep, kidney 0.200000 1.000 1.000 

DP#364

 Full comment: DP#364445

26003430 M Sheep, liver 0.200000 1.000 1.000 

DP#364

 Full comment: DP#364445

27002220 D Milk, fat 0.500000 1.000 1.000 

27002221 D Milk, fat - baby food/infant for 0.500000 1.000 1.000 

27012230 D Milk, nonfat solids 0.020000 1.000 1.000 

27012231 D Milk, nonfat solids-baby food/in 0.020000 1.000 1.000 

27022240 D Milk, water 0.020000 1.000 1.000 

27022241 D Milk, water-babyfood/infant form 0.020000 1.000 1.000 

27032251 D Milk, sugar (lactose)-baby food/ 0.020000 1.000 1.000 

86010000 O Water, direct, all sources 0.052900 1.000 1.000 

86020000 O Water, indirect, all sources 0.052900 1.000 1.000 

95001300 O Cranberry 1.900000 1.000 1.000 

95001301 O Cranberry-babyfood 1.900000 1.000 1.000 

95001310 O Cranberry, dried 1.900000 1.000 1.000 

95001320 O Cranberry, juice 1.900000 1.100 1.000 

95001321 O Cranberry, juice-babyfood 1.900000 1.100 1.000 

95002630 O Peanut 0.020000 1.000 1.000 

DP#364

 Full comment: DP#364445

95002640 O Peanut, butter 0.020000 1.890 1.000 

DP#364

 Full comment: DP#364445

95002650 O Peanut, oil 0.060000 1.000 1.000 

DP#364

 Full comment: DP#364445

95003590 O Strawberry 1.900000 1.000 1.000 

95003591 O Strawberry-babyfood 1.900000 1.000 1.000 

95003600 O Strawberry, juice 1.900000 1.000 1.000 

95003601 O Strawberry, juice-babyfood 1.900000 1.000 1.000 
Fluoxastrobin 028869 Dietary Exposure and Risk Assessment DP Number: 380847

___________________________________________________________________________________ 

 Page 12 of 13

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for FLUOXASTROBIN (1994-98 data)

Residue file name: C:\Documents and Settings\cwalls\My 

Documents\Cassi\HED\Fluoxastrobin\Fluoxastrobin_tol+water_121510.R98

 Adjustment factor #2 NOT used.

Analysis Date 12-16-2010/15:30:21 Residue file dated: 12-16-2010/15:27:05/8

Reference dose (RfD, Chronic) = .015 mg/kg bw/day

COMMENT 1: proposed squash/cucumber use, new EDWC

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ---------------

U.S. Population (total) 0.003269 21.8%

U.S. Population (spring season) 0.003304 22.0%

U.S. Population (summer season) 0.003440 22.9%

U.S. Population (autumn season) 0.003180 21.2%

U.S. Population (winter season) 0.003151 21.0%

Northeast region 0.003289 21.9%

Midwest region 0.003335 22.2%

Southern region 0.002977 19.8%

Western region 0.003646 24.3%

Hispanics 0.003765 25.1%

Non-hispanic whites 0.003245 21.6%

Non-hispanic blacks 0.002856 19.0%

Non-hisp/non-white/non-black 0.003669 24.5%

All infants (< 1 year) 0.005125 34.2%

Nursing infants 0.002053 13.7%

Non-nursing infants 0.006291 41.9%

Children 1-6 yrs 0.006259 41.7%

Children 7-12 yrs 0.003916 26.1%

Females 13-19 (not preg or nursing) 0.002568 17.1%

Females 20+ (not preg or nursing) 0.002839 18.9%

Females 13-50 yrs 0.002933 19.6%

Females 13+ (preg/not nursing) 0.003156 21.0%

Females 13+ (nursing) 0.003543 23.6%

Males 13-19 yrs 0.002860 19.1%

Males 20+ yrs 0.002804 18.7%

Seniors 55+ 0.002859 19.1%

Children 1-2 yrs 0.006979 46.5%

Children 3-5 yrs 0.006103 40.7%

Children 6-12 yrs 0.004125 27.5%

Youth 13-19 yrs 0.002720 18.1%

Adults 20-49 yrs 0.002821 18.8%

Adults 50+ yrs 0.002844 19.0%

Females 13-49 yrs 0.002765 18.4%

-------------------------------------------------------------------------------
Fluoxastrobin 028869 Dietary Exposure and Risk Assessment DP Number: 380847

___________________________________________________________________________________ 

 Page 13 of 13

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for FLUOXASTROBIN (1994-98 data)

Residue file name: C:\Documents and Settings\cwalls\My 

Documents\Cassi\HED\Fluoxastrobin\Fluoxastrobin_tol_121510.R98

 Adjustment factor #2 NOT used.

Analysis Date 12-28-2010/13:40:05 Residue file dated: 12-28-2010/13:39:07/8

Reference dose (RfD, Chronic) = .015 mg/kg bw/day

COMMENT 1: proposed squash/cucumber use; no water

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ---------------

U.S. Population (total) 0.002154 14.4%

U.S. Population (spring season) 0.002199 14.7%

U.S. Population (summer season) 0.002242 14.9%

U.S. Population (autumn season) 0.002102 14.0%

U.S. Population (winter season) 0.002073 13.8%

Northeast region 0.002272 15.1%

Midwest region 0.002208 14.7%

Southern region 0.001917 12.8%

Western region 0.002368 15.8%

Hispanics 0.002500 16.7%

Non-hispanic whites 0.002157 14.4%

Non-hispanic blacks 0.001797 12.0%

Non-hisp/non-white/non-black 0.002302 15.3%

All infants (< 1 year) 0.001470 9.8%

Nursing infants 0.000697 4.6%

Non-nursing infants 0.001763 11.8%

Children 1-6 yrs 0.004701 31.3%

Children 7-12 yrs 0.002903 19.4%

Females 13-19 (not preg or nursing) 0.001784 11.9%

Females 20+ (not preg or nursing) 0.001726 11.5%

Females 13-50 yrs 0.001854 12.4%

Females 13+ (preg/not nursing) 0.002072 13.8%

Females 13+ (nursing) 0.001999 13.3%

Males 13-19 yrs 0.002040 13.6%

Males 20+ yrs 0.001804 12.0%

Seniors 55+ 0.001764 11.8%

Children 1-2 yrs 0.005323 35.5%

Children 3-5 yrs 0.004553 30.4%

Children 6-12 yrs 0.003055 20.4%

Youth 13-19 yrs 0.001914 12.8%

Adults 20-49 yrs 0.001780 11.9%

Adults 50+ yrs 0.001749 11.7%

Females 13-49 yrs 0.001728 11.5%

-------------------------------------------------------------------------------