### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

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## UNITED STA

**TES ENVIRONMENTA L PROTECTION A** **GENCY WA** **SHINGTON, D.C. 20460**

**OFFICE OF CHEMICAL SAFETY AND**  **POLLUTION PREVENTION**



## MEMORANDUM

**Date :**  **March 10,**  **20 14** 

**SUBJECT: Thiabendazole**  Acute Probabilistic and Chronic Aggregate Dietary (Food and Drinking Water ) Exposure and Risk Assessments for Section 3 Registration for New Seed Treatment Uses on Assorted V egetables / S mall Grain s and Increase d Seed Treatment Use Rate on Soy bean.

**PC Code:** 060101 **DP Barcode:** D416470 **Decision No.:** 47671 1 **Re gistration**  **No. :**  100

- 889, 100

- 963 **Petition No**

**. :**  3F8166 **Regulatory Action:** Section 3 Registration **Risk A**  **ss essment Type**  **:** Dietary **Case No.:**  2760 **T XR No.**  **:** Not Applicable **CAS No.:** 148

- 79

- 8 **MRID No**

**. :**  Not Applicable **40 CFR:** 180.242 and 2010 **21 CFR:** 556.730

**FROM:** Bonnie Cropp

- Kohlligian, Environmental Scientist

Risk Assessment Branch IV (RABIV), Health Effects Division (HED) (7509P)

**THROUGH:** Thurston Morton , Chemist, Senior Scientist

RABIV, HED (7509P) and Sheila Piper , Chemist , Senior Scientist David Hrdy , Senior Scientist Dietary Exposure Science Advisory Council (DESAC), HED (7509P)

**TO:** Rosemary

Kearns/Tony Kish, PM 22 Fungicide Branch, Registration Division (7505P)

**Executive Summary**

Acute probabilistic and chronic aggregate dietary ( food and drinking water ) exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity

Intake Database (DEEM

- FCID) Version 3.16 . This software uses 2003

- 2008 food consumption data from the U.S. Department of Agriculture’s (USDA’s) National Health and Nutrition Examination Survey, Wh at We Eat in America, (NHANES/WWEI A). The anal ys es we re conducted in support of a human health risk assessment for the requested increase

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

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## in the currentl y registered seed treatment use rate on soy beans and the new Section 3 uses o f thiabendazole for seed treatment on assorted v egetables and s mall grain s including: vegetable, root (except sugar beet)
, subgroup1B ; radish tops; onion, bulb, subgroup 3

- 07A; Brassica , head and stem, subgroup 5 A; vegetable, cucurbit group 9; alfalfa; spinach ; and a number of sm all grain s (barley , oats, rye, and triticale). A seed treatment use is already registered for wheat and tolerance s are established for wheat grain and wheat straw but the registrant submitted a new and complete dataset for wheat with the current petition

. Also, new toxicology data have been submitted and an acute dietary endpoint has recently

been selected. This memorandum was reviewed b y two peer reviewers of the DE SAC and the entire DESAC on 3/ 6 /14 , per DESAC SOP 2012.1

.

R efined acute probabilistic and chronic dietary exposure and risk assessment s were conducted for all supported thiabendazole food uses and drinking water. Anticipated residue estimates were based on USDA PDP monitoring data for all uses except, cereal grains, citrus oil/peel, dried beans/ peas , soy beans and the proposed new seed treatment uses. Established/recommended
t olerances were used for cereal grains (corn tolerance at the method limit of quantitation; estimated at 1⁄2 LOQ )
, citrus oil/peel, dried beans, soy beans and the proposed new seed treatment

uses. R esidues based on field trial data were used for dried peas

. Because USDA PDP monitoring data did not include benzimidazole (free and conjugated), an additional factor based on available metabolism data reflecting foliar use was applied to sweet potato/yam, avocado, cantaloupe, strawberry

and mushrooms to account for this residue. Anticipated residue estimates in meat and milk considered exposure from thiabendazole

- treated feedstuffs as well as from the use of thiabendazole as an animal drug, regulated by FDA under 21 CFR §556.730 and 21 CFR §558.615

. The available percent crop treated (%CT or PCT) data for the currentl y registered seed treatment uses of thiabendazole on so ybeans and wheat (SLUA report 2/22/13) were used in the acute (maximum %CT for both <2.5) and chronic (average %CT for both <1) dietary
assessments. Tier 1 drinking water estimates were used

. DEEM default processing factors were use for all commodities except potato chips/granules/flakes and wheat processed c ommodities which relied on empirical data demonstrating that residues do not concentration in these processed commodities. Also, the maximum theoretical concentration factor for citrus peel (3.3x) was applied to orange and lemon peel; since the use on citrus is post harvest and most of the residues should be found in/on the peel.

For the probabilistic acute dietary assessment (food and drinking water) , the dietary exposure at the 99.9 th 

## percentile of exposure used 26% of the acute population adjusted dos e ( aPAD ) for the general population and 69% of the aPAD for Children 1

- 2 years, the population subgroup with the highest estimated acute dietary exposure

. Acute dietary (food and drinking water) exposures are below HED’s level of concern (<100% aPAD) for all population subgroups.

For the chronic dietary assessment, the dietary exposure used 1.1 % of the chronic population adjusted dose ( cPAD ) for th e general population and 4. 7 % of the cPAD for Children 1

- 2 years old, the population subgroup with the highest estimated chronic dietary exposure. C hronic dietary (food and drinking water) exposures are below HED’s level of concern (<100% cPAD) for all population subgroups.

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

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## Since thiabendazole is c lassified as “ **Likely** to be carcinogenic at doses high enough to cause a disturbance of the th yr oid hormonal balance but **not likely** to be carcinogenic at doses lower that those which could cause a disturbance of this hormonal balance,” a cancer dietary expo sure assessment is not required.

**I. Introduction** 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose that HED has concluded will result in no unreasonab le adverse health effects). This dose is referred to as the population

- adjusted dose (PAD). The PAD is equivalent to the point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non

- cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure fro m Pesticides, A User’s Guide,” 21

- JUN

- 2000, web link: http://www.epa.gov/fedrgstr/EPA

- PEST/2000/July /Day

- 12/6061.pdf

; or see SOP 99.6 (20

- AUG

1999).

The most recent dietary

risk assessment for thiabendazole was conducted by T. Morton ( 7/8/10
, DP Number D379937 ) . That assessment was conducted for aggregate chronic dietary exposure (food and drinking water) and risk onl y. Recentl y, an acute dietary endpoint for thiabendazole has been identified. Details concerning the selected dietary endpoints will be provided in the forthcoming risk assessment ( D416471 ).

**II. Residue Information**  Reference Memos: No DP Barcode, L. Cheng, 2/14/92 (HED Metabolism Committee

- Livestock) D165718, L. Cheng, 19 92 Phase V Review (Plant metabolism data (foliar) ) D1 70818/D169697 , L. Cheng, 1992 Phase V Review ( Livestock metabolism data) D207850 /D214188, S. Mason, 1/8/99 (Residues of concern for post harvest uses) D261103 , T. Morton, 12/2/99 ( HED MARC

- Plant , Rotational and Water) D267871, T. Morton, 9/7/00 ( HED Residue Chemistry Chapter to RED) D 366219, J. Stokes, 1/13/10 ( Most recent l ivestock diet burden calculations ) D 410807 /D410833 /D313507 , S. Hummel
, 2/25/14 ( Current Petition 3F8166 )


## Existing/Proposed Agricultural Uses: Thiabendazole is used to control a variety of fruit and vegetable diseases such as mold, blight, rot and stains caused b y various fungi. It is mostly used post harvest as a dip or spray on bananas/plantains, carrot, citrus fruits, pome fruits, potatoes, mango, and papaya. It is also registered for use on mushrooms and for use as a seed treatment on potato seed pieces , sweet potato seed pieces, soy bean, dried beans /

peas and wheat. There are also tolerances with no U.S. registrations for avocado, cantalou pe and strawberry

. [Note: Thiabendazole h ypophosphorous salt (060102) is not currentl y registered for food uses.] Now, Sy ngenta Crop Protection, Inc. is proposing uses o f thiabendazole for seed treatment on : vegetable, root (except sugar beet)
, subgroup1 B ; radish tops; onion, bulb, subgroup 3

- 07A; Brassica , head and stem, subgroup 5 A; vegetable, cucurbit group 9; alfalfa; spinach ; and a

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

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## number of small grain s (barley , oats, rye, and triticale). They are also requesting an increase in the currently

regist ered seed treatment use rate on soy beans.

Residues of Concern: The qualitative nature of the residue in plants is adequately understood based on soy

bean, sugar beet and wheat metabolism studies reflecting foliar treatments

. The HED Metabolism Assessment Review Committee (MARC) determined that residues of concern in plants for regulation and dietary risk assessment include thiabendazole and its metabolite benzimidazole (free and conjugated). No residues of 5

- hydrox ythiabendazole were identified in th ese plant metabolism studies. [Note: The 5

- hydroxy thiabendazole metabolite was identified as a minor residue in rotational crops.] Post h arvest treatments are expected to result in the highest potential residues of thiabendazole per se in/on plant commodities and potential residues of benzimidazole (free and conjugated) are unlikely to contribute significantly to the total thiabendazole residues of concern for these uses

. Based on re

- evaluation of the available foliar metabolism dat a, the reviewer has determined that maximum total thiabendazole residues of concern in so yb ean (foliage, immature plant, straw and seed) , sugar beet roots, sugar beet tops and wheat (foliage, forage, straw and grain) may be estimated by

multiplying the thi abendazole residue level b y 1.5x, 1.4x, 1. 8 x and 1.8x, respectively

. The qualitative nature of the residue in animals is adequatel y understood based on acceptable ruminant and poultry

metabolism studies. The HED Metabolism Committee determined that residues of concern in livestock for regulation and dietary risk assessment include thiabendazole, 5

- hydroxy

thiabendazole (free and conjugated), and benzimidazole

. Currently Established Tolerances: Under 40 CFR §180.242(a)(1) tolerances are established for the combined residues of thiabendazole and its metabolite benzimidazole (free and conjugated) in/on a number of crops. Tolerances range from 0.01 ppm for seed treatments to 40 ppm in/ on mushroom. There are also tolerances with no U.S. registrations in/on avocado (10.0 ppm), cantaloupe (15.0 ppm) and strawberry (5.0 ppm). Threshold of Regulation (TOR) determinations for residues of thiabendazole are established under 40 CFR §180.2010 for use as a seed treatment on dry

pea (including fie ld pea, pigeon pea, chickpea or lentil); although a tolerance level has not been established, residues are not expected to exceed 0.01 ppm (L OQ) from the maximum registered application rate of 0.075 lbs ai/100 lbs seed.

Under 40 CFR §180.242(a)(2) toleran ces are established for the combined residues of thiabendazole and its metabolites 5

- hydroxy thiabendazole (free and conjugated) and benzimidazole in: (1) milk at 0.1 ppm; (2) cattle meat at 0.1 ppm; (3) cattle, goat, horse, and sheep meat b yproducts at 0.4 ppm; and (4) hog meat by product 0.3 ppm. HED has determined that there is no reasonable expectation of finite residues of thiabendazole in poultry and egg.

Existing Animal Drug Uses: Thiabendazole is used medicinally as a chelating agent to bind
metals . In addition, it is administered to treat several helminthes species such as roundworms in livestock and humans. These medicinal uses of thiabendazole are regulated by FDA. This dietary risk assessment has considered residues incurred in livestock co mmodities from the use of thiabendazole as an animal drug regulated by FDA

.

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

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## Under 21 CFR §556.730 tolerances are established at 0.1 ppm for negligible residues of thiabendazole in uncooked edible tissues of cattle, goats, sheep, pheasants and swine, and at 0.05 ppm for negligible residues in milk. These tolerances are established for the presc ribed dosing and intervals of preslaughter withdrawal and milk discard s pecified under 21 CFR §55 8

. 615. New Recommended Tolerances: Under PP# 3F8166 , Sy ngenta Crop Protection, Inc. is petitioning for tolerances for residues of thiabendazole and its metabolite benzimidazole (free and conjugated) in/on: vegetable, root (except sugar beet), subgroup1B ; onion, bulb, subgroup 3

- 07A; Brassica , head and stem, subgroup 5 A; vegetable, cucurbit group 9; alfalfa seed ; spin ach ; and barley , oats, rye, and triticale grains; and livestock feedstuffs (forage, hay , and straw) of alfalfa, barley
, oats, rye, wheat and triticale . H ED is recommending the tolerance s (excluding livestock feedstuffs) below for residues of thiabendazole and its metabolite benzimidazole (free and conjugated) :
Vegetable, root (except sugar beet ), subgroup 1B

........................... 0.02 ppm Onion, bulb, subgroup 3

- 07A

................................ .......................... 0.02 ppm Brassica
, h ead and s tem, subgroup 5

- A

................................ ........... 0.02 ppm Vegetable, cucurbit, group 9

................................ ............................ 0.02 ppm Spinach

................................ ................................ ............................. 0.02 ppm Barley , grain

................................ ................................ ..................... 0.05 ppm Oat, grain

................................ ................................ .......................... 0.05 ppm Rye, grain

................................ ................................ ......................... 0.05 ppm Triticale, grain

................................ ................................ .................. 0.05 ppm
HED has determined that it is not appropriate to set a tolerance in/on alfalfa seed and the currentl y established tolerance in/on so ybean (0.1 ppm) is adequate for the requested increased seed treatment use rate on soy beans

. A long with PP#3F8166, Sy ngenta Crop Protection, Inc. submitted a new and complete dataset for wheat grain supporting the existing seed treatment use on wheat. Although not petitioned

- for, H ED is recommending th at the current tolerance in/on wheat grain be lowered from 1.0 ppm (established for foliar uses that no longer exist) to 0.05 ppm consistent with the new data.

**Crop Commodities** 

**- Anticipated Residues** 

R efined acute probabilistic and chroni c dietary exposure assessments were conducted for thiabendazole using anticipated residue estimates for all existing uses except, cereal grains, citrus oil/peel, dried beans/

peas and soy

beans. Established/recommended tolerances were used for cereal grains ( corn tolerance at the method limit of quantitation; estimated at 1⁄2 L OQ ) , citrus oil/peel, dried beans, soy

beans and the proposed new seed treatment uses. Maximum residues based on field trial data were used for dried peas

. Anticipated residue estimates for carrot, potato, sweet potato, cantaloupe, orange, apple, pear bab y food, strawberry , mushrooms, avocado, banana, mango, and papaya were based on USDA PDP monitoring data for thiabendazole and translated, as appropriate to yams, other citrus fruits, other pome fruits and plantains. Because USDA PDP monitoring data did not include benzimidazole (free and conjugated), an additional factor based on available metabolism data reflecting foliar use was applied to sweet potato/yam, avocado, cantaloupe, strawberry and mushrooms to account for this residue. The factor (1.4x) applied to sweet potato/yam was based on sugar beet root metabolism

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## data and the factor (1.8x) applied to avocado, cantaloupe, strawberry and mushrooms was based on the maximum factor identified in any of the metabolism studies. See Attachment 1 for details

. USDA PDP findings for the metabolite 5

- hydroxythiabendazole: The HED MARC determined that residues of concern in plants for regulation and dietary risk assessment include thiabendazole and its metabolite benzimidazole (free and conjugated). No residues of 5

- hydrox ythiabendazole were identified in the plant metabolism studies re flecting foliar use and it was not identified as a significant residue in the rotational crops studies. Hence, based on available residue chemistry data, 5

- hydroxy

thiabendazole was not deemed a significant residue in crops.

USDA PDP did generate some l imited data for 5

- hydroxy thiabendazole (assumed to be free only) because it was easily determined by

the data

- collection methods (personal communication with D. Hrdy)

. For some of the USDA PDP data used in the dietary assessments, HED found that detectable residues of 5

- hydrox ythiabendazole were also detectable in/on some of the apple, apple juice, apple sauce, banana, orange, orange juice and potato samples used in the dietary
assessments . However, detailed anal ys es of the individual sample data (personal communication with S. Nako) found that these detectable levels of 5

- hydroxy thiabendazole did not rise to a level of significance as a percentage of the levels of the parent present (<10%) for all but orange juice ; and in the case of orange juice
, the level s detected were extremely low ( ≤ 0.002 ppm) and nearly equal to the LOD of the data

- collection method (0.001 ppm) for 5

- hydroxy thiabendazole in/on orange juice

. See Table 1 below for details. Hence, these detectable levels of 5

- hydrox ythiabend azole are of little consequence to the dietary risk assessments and were not included. Thus far, analy ses of all of the available USDA PDP 5

- hydroxy thiabendazole data (up through 2012 and with respect to levels in the absolute and/ or as a percent of the residues of parent) do not seem to contradict the HED MARC decision that residues of 5

- hydrox ythiabendazole are not a residue of concern in/on crops

.

**Table 1**  **. USDA PDP Data for Detectable Residues of**  **Free 5** 

**- Hydroxythiabendazole (5** 

**- Hydroxy)** 

**. 1** 


### Commodities with D etects /Years with D etects and

u sed in Dietary Assessments Detects Found (Number of samples or ppm) Percent Detects Relative to Parent (%) Sam ples with 5

- Hydroxy and Parent Detected/Total Used in Dietary Assessment 1 

### Sam ples with Only 5

- Hydroxy Detected Maximum

5

- Hydroxy Detected (ppm) mean max Apple /2009 10 /1162 0 0.018 1. 0 1. 8 Apple Juice /2007 and 2008 14 /183 0 0.0043 1. 6 2.4 Apple Sauce /2006 39 /744 1 0.019 2. 7 8.3 Banana/2006 an d 2007 60 /2045 0 0.002 7. 5 2 4 Orange /2009 2 /1488 0 0.005 3. 4 3. 8 Orange Juice /2006 8 /1106 0 0.002 2 4 **30** Potato /2008 and 2009 6 /1488 0 0.017 1. 1 3.0
1 

### Not all samples used in the dietary analyses were analyzed for residues of 5

- hydroxythiaben dazole. This table only includes data for samples u sed in the current dietary risk assessments which were found to have detectable residues of thiabendazole and 5

- hydroxythiabendazole . These data were extracted from a more complete analysis of the available USDA PDP 5

- hydroxythiabendazole data conducted by S . Nako.

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## Livestock Commodities

**- Anticipated**  **Residues**

Under 40 CFR §180.242(a)(2) tolerances are established for the combined residues of thiabendazole and its metabolites 5

- hydroxy thiabendazole (free and conjugated) and benzimidazole in: (1) milk at 0.1 ppm; (2) cattle meat at 0.1 ppm; (3) cattle, goat, hors e, and sheep meat b yproducts at 0.4 ppm; and (4) hog meat by product 0.3 ppm. HED has determined that there is no reasonable expectation of finite residues of thiabendazole in poultry and egg. In the most recent evaluation of maximum reasonably balanced dietary burdens for ruminants and available ruminant livestock metabolism and magnitude of the residue data, HED found that some of the established livestock tolerance s could be lowered but did not recommend this action. Livestock feedstuffs in the current petition are not expected to increase the most recent maximum reasonably

balanced dietary

burden estimates.

The maximum reasonably balanced dietary burdens for beef and dairy cattle are 21 ppm and 9.2 ppm, respectivel y. In the ruminant feeding study ( MRID 40271707) , thiabendazole was fed to dairy cows (3 animals/dose group) at levels of 25, 75, and 250 ppm in the diet for 28 consecutive day s. These feeding levels are equivalent to 1.2x, 3.6x, and 1 2 x the dietary burden for beef cattle (21.0 ppm) and 2 .7x, 8.2x, and 27x the dietary burden for dairy

cattle (9.2 ppm). Residues of thiabendazole and 5

- hydroxy thiabendazole (free and conjugated) were determined in fat, kidney
, liver and muscle within 24 hours of the last dose (day 29) and after a depuration period of nearl y 30 day s (day

57). Residues of thiabendazole and 5

- hydroxy thiabendazole (free and conjugated) were determined in milk on day s 1, 2, 4, 7, 14, 21 and 28 of the dosing period and on day s 29, 35, 42, 49 and 56 of the depuration period

.

A lthough residues of benzimidazole were not determined in the feeding study
, based on the goat metabolism study, finite residues of benzimidazole are not expected in milk and should not be greater than 0.7x the level of 5

- hydroxy thiabendazole residues found i n tissues

. The metabolite, 5

- hydroxy

thiabendazole w as the major residue in kidney , liver and milk; it was an order of magnitude or more than parent. M aximum combined residues of thiabendazole, 5

- hydrox ythiabendazole (free and conjugated) and benzimidazol e from exposure to thiabendazole

treated feedstuffs in fat, kidney , liver, m eat and milk are estimated at 0.0 05 ppm, 0.2 ppm, 0.0 7 ppm, 0.00 1 ppm and 0.01 7 ppm, respectivel y

. See Table 2 below for details and calculations.

**Table 2** 

**. Maximum residues of thiabendazole (TBZ** **), 5**

**- hydroxythiabendazole (5** 

**- OH** 

**- TBZ) and**  **benzimidazole (BNZ ) based on**  **days 2**

**- 28 of t**  **he cattle feeding study (MRID 40271707).** 

Matrix Feeding

Level (ppm) 1 

### TBZ

Found (ppm) 5

- OH

- TBZ

Found (ppm) BNZ

Estimated (ppm) 2 

### Com

bined Residues (ppm) Sum of residues found Adjusted

for residues in control 3 

### Adjusted to

1x feeding level

Fat 0 0.017 0.002 0.001 0.020

-- --

25 0.018 0.004 0.003 0.025 0.005 0.0 04 **75 0.017**  **0.012 0.008**  **0.037 0.017**  **0.0 05**  250 0.015 0.010 0.007 0.032 0.012 0.00 1 Kidney 0 0.018 0.009 0.006 0.033

-- --

25 0.012 0.049 0.034 0.095 0.062 0.0 5 **75 0.017**  **0.421 0.295**  **0.733 0.700**  **0. 2**  250 0.030 0.546 0.382 0.958 0.925 0.0 8

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

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-- --

25 0.022 0.028 0.020 0.070 0.034 0.0 3 **75 0.060**  **0.130 0.091**  **0.281 0.245**  **0.0 7**  250 0.080 0.156 0.109 0.185 0.149 0.01 Muscle 0 0.015 0.003 0.002 0.020

-- --

25 0.014 0.003 0.002 0.019 <0.001 < 0.0 01 **75 0.014**  **0.006 0.004**  **0.024 0.004**  **0.00 1**  250 0.017 0.005 0.004 0.026 0.006 < 0.00 1
Milk 4 

### 0 0.019 0.005 zero 0.024

-- --

25 0.01 8 0.01 8 0.0 36 0.012 0.0 04 **75 0.01**  **4 0.1**  **48 0.1**  **62 0.138**  **0.0 17**  250 0.01 6 0. 246 0.2 62 0.238 0.0 09 1 The 25, 75, and 250 ppm dose levels are equivalent to 1.2x, 3.6x, and 1 2 x the maximum reasonably balanced dietary burden of beef cattle (21 ppm) and 2.7x, 8.2x, and 27x the maximum reasonably balanced dietary burden of dairy cattle (9.2 ppm) , respectively

. 2 Residues of benzimidazole were not determined in the cattle feeding study so estimates of benzimidazole are based on the goat metabolism study. Based on these data b enzimidazole residues would not exceed 0.7x the residues of 5

- hydroxythiabendazole (free and conjugated) fo und in tissues

. Residues of benzimidazole were not detected in milk from the goat metabolism study. 3 Com bined Residues in treated samples are adjusted for Combined Residues in control samples

. Source of residues in control samples was not specified in the submission but is likely a consequence of the data collection method which used fluorometry detection. 4 Residue data are from milk samples collected on days 2

- 28 of dosing period. Residues in milk plateau around day 4 of the dosing period. Residues of 5

- hydroxythiabendazole were an order of magnitude greater than parent at the higher doses.


## In the depuration study , residues of thiabendazole and 5

- hydrox ythiabendazole in samples of tissues and milk from all dosing levels were nearl y equal to residues in the control samples after a depuration period of about 30 day s (day 57) and 4 day s (first depuration day tested for milk samples) , respectivel y.
Thiabendazole is also registered as an animal drug by FDA and under 21 CFR §55 8

. 615 it is prescribed for use in feeds of cattle (max. 5 g/100 lb body weight), goats (max. 3 g/100 lb body weight), sheep (max. 2 g/100 lb body weight) , swine (max. 0.1 % in feed continuously for 2 weeks followed b y 0.02 % in feed for 8

- 14 weeks) and peasants (max. 0.05 % in feed continuously

for 2 weeks). Lengthy

preslaughter withdrawal intervals (21

- 30 day s) are imposed for all but cattle (3 day s) . Also, there is a significant milk discard interval (4 day s; within 96 h ours (8 milkings) ) . Related tolerances are established under 21 CFR §556.730 at 0 .1 ppm for negligible residues of thiabendazole in uncooked edible tissues of cattle, goats, sheep, swine and pheasants, and at 0.05 ppm for negligible residues in milk. A t olerance for negligible residues is required when it is not possible to determine whether finite residues will be incurred but there is reasonable expectation that they may be present (21 CFR §556.1(a)(2)). Hence, it can be assumed that these tolerances are established at a limit of quantitation and residues for thiabendazole used as an animal drug can be estimated at 1⁄2LOQ. Therefore, residues of thiabendazole from the use as an animal drug should not be greater than 0.05 ppm and 0.025
ppm ( 1⁄2L OQ ) in treat ed livestock ti ssues and milk, respectivel y. Moreover, given the lengthy prescribed preslaughter withdrawal intervals for all but cattle, it would be reasonable to estimate anticipated residues of thiabendazole in the edible tissues of goats, sheep, swine and pheasants for the purposes of dietary risk assessment at nil. The available feeding/depuration study data indicate that residues do not plateau in milk for 3

- 4 day s and decline rel atively rapidly once

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

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## dosing is terminated; hence the single dose and prescribed milk discard interval (4 days) should ensure that residues in milk should be extremely low.

There are e xtensive USDA PDP data available for milk (2004

- 2005) which found no det ectable residues of thiabendazole (<0.001 ppm) in 1485 samples and for heav y cream (2007) which found no detectable residues of thiabendazole (<0.008 ppm) or 5

- hydrox ythiabendazole ( < 0.025 ppm) in 742 samples . [Note: Heav y cream samples from 2005 and all milk samples were not anal yz ed for residues of 5

- hydroxy thiabendazole.] Milk s amples were not anal yz ed of residues of 5

- hydrox ythiabendazole; however, based on the cattle feeding study , residues of 5

- hydrox ythiabendazole (free and conjugated) could be es timated at an order of magnitude greater that parent. Hence, the estimated combined residues of parent and 5

- hydroxy thiabendazole (free and conjugated) in milk would be < 0.01 ppm

.

Conclusions: Under 40 CFR §180.242(a)(2) tolerances are established for the combined residues of thiabendazole and its metabolites 5

- hydrox ythiabendazole (free and conjugated) and benzimidazole in: (1) milk at 0.1 ppm; (2) cattle meat at 0.1 ppm; (3) cattle, goat, horse, and sheep meat b yproducts at 0.4 ppm; and (4) hog meat b yproduct 0.3 ppm. HED has determined that there is no reasonable expectation of finite residues of thiabendazole in poultry and egg. Based on available livestock feeding study data, maximum thiabendazole residues of concern resulting from exposure to thi abendazole

- treated feedstuffs are estimated at 0. 0 05 ppm in fat
, 0.2 ppm in kidney
, 0.0 7 ppm in liver and 0.00 1 ppm in meat

. The estimate in kidney (0.2 ppm) will be translated to meat

- by

products. These estimates will also cover anticipated residues of thiabendazole in tissues from the use of thiabendazole as an animal drug with the exception s of beef meat and beef fat

.

Thiabendazole is also used as an animal drug, regulated by FDA
, and tolerances are established under 21 CFR §556.730 for residues of th iabendazole at 0.1 ppm for negligible residues of thiabendazole in uncooked edible tissues of cattle, goats, sheep, pheasants and swine, and at 0.05 ppm for negligible residues in milk. However, given the lengthy prescribed preslaughter withdrawal interval s (21

- 30 day s) for all but cattle (3 day s) , it would be reasonable to estimate residues of thiabendazole in the edible tissues of goats, sheep, swine and pheasants for the purposes of dietary risk assessment at nil. Therefore, residues of thiabendazole are estimated at 0.05 ppm (1⁄2L OQ) in beef meat and beef fat

. [Note: Available feeding and metabolism data indicate that parent is the major residue in meat and fat.] These estimates will also cover anticipated residues of thiabendazole in these tissues from exposure to thiabendazole

- treated feedstuffs

.

There are e xtensive USDA PDP data available for milk (2004

- 2005) which found no detectable residues of thiabendazole (<0.001 ppm) in 1485 samples and for heav y cream (2007) which found no detectable residue s of thiabendazole (<0.008 ppm) or 5

- hydrox ythiabendazole ( < 0.025 ppm) in 742 samples . [Note: Heav y cream samples from 2005 and all milk samples were not anal yz ed for residues of 5

- hydroxy thiabendazole.] Milk samples were not anal yz ed of residues of 5

- h ydrox ythiabendazole; however, based on the cattle feeding study, residues of 5

- hydrox ythiabendazole (free and conjugated) could be estimated at an order of magnitude greater that parent. Hence, the estimated combined residues of parent and 5

- hydroxy thiabendazole (free

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

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## and conjugated) in milk would be < 0.01 ppm. Based on the available metabolism data, residues of benzimidazole are not expected in milk.

**Fish**

N o tolerances are currently established for residues of thiabendazole in fish. The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 2009, and 2010. Only the catfish samples collected in 2008 (552 samples) were anal yz ed for residues of thiabendazole and onl y one was found to have detectable residues of thiabendazole (0.0031 ppm) at a level very

close to the limit of detection (0.002 ppm). As a result, residues in fish were not included in the assessment

.

**I I**  **I. Percent Crop Treated Information** 

The available percent crop treated (%CT or PCT) data for the currently registered seed treatment uses of thiabendazole on soy beans and wheat (SLUA report 2/22/13) were used in the acute and chronic dietary

assessments. The following maximum percent crop treated estimates were used in the acute dietary

risk assessment for the following crops that are currently registered for thiabendazole : soy

beans 2.5% and wheat 2.5%. The following average percent crop treated estimates were used in the chronic dietary risk assessment for the following crops that are currentl y registered for thiabendazole : soy beans 1 % and wheat 1%. The available %CT data for the currently registered seed treatment use of thiabendazole on potatoes was not use since there is also a post harvest use on potatoes. No other %CT data are available according to BEAD ( Email dated 12/12/13 from S. Haddad (BEAD) to T. Morton (HED) ) and , therefore, 100% crop treated was assumed for all other existing/proposed uses. See Attachment 9.

**IV. Drinkin g Water Data** 

**-** EFED Memo: D410805, 2/24/ 14 , J. Wolf. (Drinking Water Assessment (DWA))



## The drinking water estimates used in the dietary risk assessment were provided by the Environmental Fate and Effects Division (EFED; D410805) . EFED conducted a Tier I drinking
water assessment for thiabendazole i n surface water using the FQPA Index Reservoir Screening Tool (FIRST) model and in ground water using the Pesticide Root Zone Model for GroundWater ( PRZM

- GW ). The highest E stimated D rinking W ater Concentration s (EDWCs) resulted from the currently

registered use of thiabendazole on wheat as a seed treatment and not from the proposed new uses or requested soy bean use rate increase. Surface water estimates w ere higher than ground water estimates. The highest EDWCs for peak and annual mean were 3.80 and 0.47 μg/L(ppb), respectively . The peak concentration of 0.0038 ppm and annual mean of 0.00047
ppm were used in the acute and chronic dietary exposure anal ys es, respec tively

. See Table 3 below for details.

**Table 3** 

**. Summary of Tier 1 Estimated Drinking Water Concentrations in Surface and Ground Water for**  **the New Uses and Previously Assessed Wheat Use.**

New Uses and Reassessment **Thiabendazole Peak Concentration**  **Annual Average** Surface Water Crop (app rate lb a.i./A) Model **μg/L**

New Uses (0.15) FIRST 2.85 0.35 Wheat (0.20) FIRST 3.80 0.47

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 11 of 47 From RED Peak Concentration 56

- day Average Wheat (0.20) GENEEC 2.40 1 

### 1.55 1 

### Groundwater Highest Daily Concentration Average Concentration after Breakthrough New Uses (0.15) PRZM

- GW 0.46

- Wheat (0.20) PRZM

- GW 0.62

- 1 

### The highest EDWCs in surface water for thiabendazole were previously prepared for the 2002 Reregistration Eligibility D ecision (RED), using the Tier 1 GENEEC model (which has since been replaced by the FIRST model) for surface water and the SCI

- GROW model (which has since been replaced with PRZM

- GW) for groundwater. The peak concentrations are higher than previously determined fo r the RED primarily due to changes in the conceptual model (GENEEC vs. FIRST) (e.g., differences of field size and shape and the implementation of the Index Reservoir) and difference in fate input values for modeling. The chronic EDWCs are lower than befor e due the inclusion of the Index Reservoir (e.g., size and flow through the reservoir).



## The drinking water model s and their description s are available at the EPA internet site: http://www.epa.gov/ oppefed1/models/water/

.

**V. DEEM** 

**- FCID Program and Consumption Information** 

Thiabendazole acute probabilistic and chronic dietary exposure assessments were conducted using the DEEM

- FCID, Version 3.16 , which incorporates 2003

- 2008 consumption data from USDA’s NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 individuals over two non

- consecutive survey day s. Foods “as consumed” (e.g., apple pie) are linked to EPA

- defined food commodities (e.g.
, apples, peeled fruit

- cooke d; fresh or N/S; baked; or wheat flour

- cooked; fresh or N/S, baked) using publicl y available recipe translation files developed jointly

by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population an d within population subgroups . However , for acute exposure assessment , consumption data are retained as individual consumption events. Based on anal ys is of the 2003

- 2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and a dults 50

- 99
ye ars old.

For a chronic dietary

exposure assessment, an estimate of the residue level in each food or food

form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average dail y consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average esti mated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup.

For an acute exposure assessment, individual one

- day food consumption data are used on an individual

- b y

- individual basis. The reported consumption amounts of each food item can be multiplied by

a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 12 of 47 

## and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., onl y those who reported eating relevant commodities/food forms) and a per

- capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for analy ses performed at all levels of refinement . However, for deterministic assessments
, any significant differences in user vs. per capita exposure and risk are specificall y identified and noted in the risk assessment.

**VI. Toxicological Information** 

The doses and toxicological endpoints selected for dietary risk assessment are summarized in Table 4 below

. Since the most recent dietary assessment, an acute dietary endpoint has been selected. For details on the selected dietary endpoints , see the forthcoming risk assessment ( D 416471 ).

**Table 4** 

**. Summary of Toxicological Doses and Endpoints**  **for Thiabendazole**
**Exposure/ Scenario**  **Point of Departure**  **Uncertainty/FQ**

**PA Factors Level of Concern for** 

**Risk Assessment**  **Study and Toxicological Effects**

Acute Dietary (general population including females 13

– 49 years and children ) NOAEL = 5 0 mg/kg/day UF A = 10 x

UF H = 10x FQPA = UF DB = 10x aRfD =

0. 05 mg/kg/day

aPAD = 0. 05 mg/kg/day Acute neurotoxicity Study MRID 48996309 LOAEL = 200 mg/kg based decreases in the FOB (reduced body temperature in males p<0.05, and reduced rearing in females ↓54%, p<0.01), reduced locomotor activity in males and females ( ↓37

- 46%, p<0.01), at time of peak effect (approximately 3 hours post

- dose). Reduced body weight gain (p<0.01) and food consumption ( ↓44%, p<0.01) occurred on day 1.

Chronic Dietary NOAEL = 10mg/kg/day UF A = 3x

UF H = 10x FQPA = UF DB = 10x cRfD =

0.033 mg/kg/day cPAD = 0.033 mg/kg/day 2

- Year chronic c arcinogenicity in the Rat MRID 43593201

co

- critical with subchronic toxicity rat study MRID 42942802 Chronic LO AE L = 30 mg/kg/day based on decreased body weight gains and liver hypertrophy

. Thiabendazole induced thyroid adenomas in male rats at dosages of ≥30 mg/kg/day.

Subchronic LO AE L = 40 mg/kg/ based on reduced body weight and body weight gains (( ↓11%) and histopathological changes in the bone marrow (erythroid hyperplasia), liver (centrilobular hypertrophy), thyroid (follicular cell hypertrophy) and spleen (pigmented). Cancer (all routes) **Lik ely**  to be carcinogenic at doses high enough to cause a disturbance of the thyroid hormonal balance but **not lik ely**  to be carcinogenic at doses lower that those which could cause a disturbance of this hormonal balance (TXR 0050554). Point of Departure (POD) = A data point or an estimated point that is derived from observed dose

- response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UFA = extrapolation from anima l to human (interspecies). UF H = potential variation in sensitivity among members of the human population (intraspecies). UF DB = to account for the absence of key date (i.e., lack of a critical study). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose. MOE = margin of exposure. LOC = level of

concern. DAF = dermal absorption factor (TXR 0055373 )



## VII. **Results/Discussion**

F or acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM

- FCID anal ys es estimate the dietary exposure of the U.S. population and various population subgroups. The acute and chronic results reported in Table 4 are for the general U.S. p opulation, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, females 13

- 49, adults 20

- 49, and adults 50+ years.

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## Estimated acute and chronic dietary exposure s to thiabendazole from food and drinking water are below HED’s level of concern for all population su bgroups

. The c ombined acute dietary exposure from food and drinking water at the 99.9 th 

## percentile of exposure is estimated at 0. 0 129 53 mg/kg/day

for the general population, equival ent to 26 % of the aPAD. The population subgroup with the highest estimate d acute dietary exposure is children 1

- 2 years , with an estimated exposure at the 99.9 th 

## percentile of 0.0 34322 mg/kg/day , equivalent to 69 % of the aPAD. The combined chronic dietary exposure from food and drinking water is estimated at 0.0003 79 mg/kg/day for the general population ( 1. 1 % of the cPAD) and 0.00 1562 mg/kg/day the most highly

exposed population subgroup , Children 1

- 2 years old ( 4. 7 % cPAD). The results for all populations are summarized in Table 5 below.

Since thiabendazole is classified as “ **Likely** to be carcinogenic at doses high enough to cause a disturbance of the th yr oid hormonal balance but **not likely** to be carcinogenic at doses lower that those which could cause a disturbance of this hormonal balance ,” a cancer dietary exposure

assessm ent is not required.

**Table 5**  **. Summary of Dietary** (Food and Drinking Water) **Exposure and Risk for Thiabendazole** 

**.**

**Population Subgroup Acute Dietary**  **( 99.9**  **Percentile) Chronic Dietary**  **Cancer**
**Dietary Exposure**  **(m g/kg/day)**  **% aPAD*** **Dietary Exposure**  **(m g/kg/day)**  **% cPAD*** **Dietary Exposure**  **(m g/kg/day)**  **Risk**

General U.S. Population 0. 0 129 53 26 0.0003 79 1. 1 All Infants (<1 year old) 0.021 098 42 0.00061 2 1.9



## N/A N/A **Children 1**

**- 2 years old**  ***** **0.034 322**  **69 0.00156**  **2 4.**  **7** Children 3

- 5 years old 0.0282 11 56 0.00108 1 3.3 Children 6

- 12 years old 0.01786 5 36 0.000 597 1.8
Youth 13

- 19 years old 0.0090 42 18 0.00029 5 0.9 Adults 20

- 49 years old 0.0075 28 15 0.0002 67 0.8 Adults 50

- 99 years old 0.0077 86 1 6 0.00027 6 0.8
Females 13

- 49 years old 0.0077 89 16 0.00025 6 0.8 *T he population subgroup (s) with the highest risk estimates

.



## VIII. **Characterization of Inputs/Outputs**

With regards to food, refined acute probabilistic and chronic dietary exposure assessments were conducted for thiabendazole using anticipated residue estimates for all existing uses except, cereal grains, citrus oil/peel, dried beans/ peas and soy

beans. Established/recommended tolerances were used for cereal grains ( corn tolerance at the method limit of quantitation; estimated at 1⁄2 L OQ ) , citrus oil/peel, dried beans, soy beans and the proposed new seed treatment uses. Maximum residues based on field trial data were used for dried peas. Anticipated residue estimates for carrot, potato, sweet potato, cantaloupe, orange, apple, pear bab y food, strawberry
, mushrooms, avocado, banana, mango, and papaya were based on USDA PDP monitoring data for thiabendazole and translated, as appropriate to yams, other citrus fruits, other pome fruits and plantains. Because USDA PDP monitoring data did n ot include benzimidazole (free and conjugated), an additional factor based on available metabolism data reflecting foliar use was

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

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## applied to sweet potato/yam, avocado, cantaloupe, strawberry and mushrooms to account for this residue

.

There is no reasonabl e expectation of finite residues of thiabendazole in poultry and eggs. Anticipated residue estimates in meat and milk considered exposure from thiabendazole

- treated feedstuffs as well as from the use of thiabendazole as an animal drug, regulated by FDA

. Anticipated residue estimates in tissues with the exceptions of beef meat and beef fat were based

on feeding study data . Anticipated residue estimates in the meat and fat of beef were based on tolerances established under 21 CFR §556.730 for residues o f thiabendazole at 0.1 ppm for negligible residues of thiabendazole in tissues. The anticipated residue estimate in milk was based on USDA PDP data for parent and available feeding study data for its metabolite , 5

- hydrox ythiabendazole (free and conjugated) . All estimates were supported by available ruminant metabolism data.

DEEM default processing factors were use for all commodities except potato chips /granules/flakes and wheat processed commodities which relied on empirical data demonstrating that resi dues do not concentration in these processed commodities

. Also, the maximum theoretical concentration factor for citrus peel (3.3x) was applied to orange and lemon peel, since the use on citrus is post harvest and most of the residues should be found in/o n the peel.

The available percent crop treated (%CT or PCT) data for the currently registered seed treatment uses of thiabendazole on soy beans and wheat (SLUA report 2/22/13) were used in the acute (maximum %CT for both <2.5) and chronic (average %CT for both <1) dietary assessments. The available %CT data for the currently registered seed treatment use of thiabendazole on potatoes was not use since there is also a post harvest use on potatoes. No other %CT data are available according to BEAD (Email date d 12/12/13 from S. Haddad (BEAD) to T. Morton (HED) ) and, therefore, 100% crop treated was assumed for all other existing/proposed uses.

The drinking water estimates used in the dietary risk assessment were provided by the Environmental Fate and Effects D ivision (EFED; D410805). EFED conducted a Tier I drinking water assessment for thiabendazole in surface water using the FQPA Index Reservoir Screening Tool (FIRST) model and in ground water using the Pesticide Root Zone Model for GroundWater ( PRZM

- GW ). The highest Estimated Drinking Water Concentrations (EDWCs) resulted from the currently

registered use of thiabendazole on wheat as a seed treatment and not from the proposed new uses or requested soy bean use rate increase. Surface water estimates were higher than ground water estimates. The highest EDWCs were 3.80 and 0.47 μg/L (ppb) for peak and annual mean, respectively. The peak concentration of 0.0038 ppm and annual mean of 0.00047 ppm were used in the acute and chronic dietary exposure anal ys es, res pectively

. Estimated acute dietary

exposures to thiabendazole from food and drinking water are below HED’s level of concern for all population subgroups . The c ombined acute dietary exposure from food and drinking water at the 99.9 th 

## percentile of exposure is estimated to 0. 0 129 53 mg/kg/day for the general population, equival ent to 26 % of the aPAD. The population subgroup with the highest estimated acute dietary exposure is children 1

- 2 years , with an estimated exposure at the 99.9 th 

## percentile of 0.0 34322 mg/kg/day , equivalent to 69 % of the aPAD

. The major risk drivers

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## were fresh apple with peel (58%)
, fresh pear ( 14 %) and apple juice (9%) f or the most highl y exposed population subgroup (Children 1

- 2 years). Anticipated residue estimates for these food fo rms were based on available USDA PDP data. Available apple and apple juice data were used directly and apple data w ere translated to pear. [Note: For pears, the r eviewer used the more recent USDA PDP data for apple (2009 and 2010 ) rather than the older USDA PDP data for pear (2003

- 2005). USDA PDP data for pear in 2009 and 2010 did not analyze for residues of thiabendazole.] USDA PDP findings for these food forms were relativel y high with regards to both level and frequency most likely due to the post harvest use on these crops

. The anal ys es assumed 100% crop treated in the absence of more specific data . Tier 1 drinki ng water estimates were used ; however, drinking water did not contribute significantly to the dietary

exposure fo r any of the population subgroups. [See Attachment 5 for acute results for food only .] A dditional percent crop treated data and/or further refinements to the drinking water estimates might be of little value to further refinements of the acute dietary as sessments

. Chronic dietary

exposure estimates for food and drinking water are well below HED’s level of concern (<100% CPAD) for all population subgroups. The dietary exposure is estimated at 0.0003 79 mg/kg/day

for the general population ( 1. 1 % of the cPAD) and 0.00 1562 mg/kg/day ( 4. 7 % of the cPAD) for Children 1

- 2 years old , the population subgroup with the highest estimated chronic dietary exposure.

**IX. Conclusions** 

R efined acute probabilistic and chronic dietary exposures were conducted for all supported thiabendazole food uses and drinking water. For the acute assessment, aggregate dietary ( food and drinking water) exposure s are below HED’s level of concern (<100% aPAD) at the 99.9 th 

## percenti le of exposure for all population subgroups. The c ombined acute dietary exposure from food and drinking water at the 99.9 th 

## percentile of exposure is estimated to 0. 0 129 53 mg/kg/day for the overall U.S. population, equival ent to 26 % of the aPAD. The population subgroup with the highest estimated acute dietary exposure is children 1

- 2 years , with an estimated exposure at the 99.9 th 

## percentile of 0.0 34322 mg/kg/day , equivalent to 69 % of the aPAD

. Chronic dietary

exposure estimates for food and drinking w ater are well below HED’s level of concern (<100% CPAD) for all population subgroups. The dietary exposure is estimated at 0.0003 79 mg/kg/day

for the general U.S. population ( 1. 1 % of the cPAD) and 0.00 1562 mg/kg/day

( 4. 7 % of the cPAD) for Children 1

- 2 years old , the population subgroup with the highest estimated chronic dietary exposure.

**X. List of Attachments** 

• Attachment 1. Data and Residue Estimates Used in the Dietary Exposure Analy ses

• Attachment 2 . Residue Distribution Files for Acute Anal ys is

• Attachment 3

. Acute R esidue Input file

• Attachment 4

. Acute Results

- Food and Drinking Water

• Attachment 5 . Acute Results

- Food only

• Attachment 6

. CEC for Most Highly Exposed Population Subgroup (Children 1

- 2 years)

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Page 16 of 47 

## • Attachment 7

. Chronic Residue Input file

• Attachment 8

. Chronic Results File

• Attachment 9

. Screening L evel Usage Anal ys is (SLUA) for Thiabendazole (060101)

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

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## Attachment 1. Data and Residue Estimates Used in the **Dietary Exposure Analyses**

**Table 1**  **. Data and Residue Estimates Used in the Dietary Exposure Analyses.**

RAC Food

Forms Blending

Classif i

cation 1 Data

Source 2 Number

of Samples Detectable Residues Non

- Detectable Residues %CT 3 Processing Factors 4 Anticipated Residue

Estimates/Tolerance 5 **Factor for**  **Metabolite 6** 

Number [ Percent] Max

(ppm) Average

(ppm) Number Max.

LOD /LOQ (ppm) Acute Chronic

**Mem bers of Root and**  **Tuber Vegetables (Crop Group 1) 7** 
Carrot root PB or NB PD P

2007 2006 1488 6 [ <1 % ] 0.004 8 0.002567 1482 0.03

100 DEEM default RDF#5 PD P Average 0.0149 ppm9 None. Post

harvest Use.

baby food PB or

NB PD P

2012 792 0

-- -- 792 0.004 PD P Maximum/Average 0.002 ppm (1⁄2LOD) juice PB or

NB Translate PDP Carrot Root Data RDF#5 PD P Average 0.0149 ppm9
Potato tuber PB or NB PD P

2009 2008 1488 114 [ 8 % ] 1.5 0.195919 1374 0.03 DEEM default RDF#7 PD P Average 0.0289 ppm9 None. Post

harvest Use.

chips B Translate PDP Potato Tuber Data 1.0 10 PD P Average 0.0289 ppm9 granules/ flakes B

flour B DEEM default Sweet Potato tuber PB or NB PD P

2010 2009 2008 1476 8 [ <1 % ] 0.014 0.006125 1468 0.01 DEEM default RDF#12 PD P Average 0.005 ppm9 1.4x

baby food PB or

NB PD P

2011 2010 776 0

-- -- 776 0.003 PD P Maximum/Average 0.0015 ppm (1⁄2LOD)

Yam tuber NB Translate PDP Sweet Potato Tuber Data RDF#12 PD P Average 0.0050 ppm9 Vegetables, root (except sugar beet), subgroup 1B root/tuber PB or NB Tolerance Not Applicable (N/A) Tolerance 0.02 ppm None.

Ginseng dried B

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Page 18 of 47 **Table 1**  **. Data and Residue Estimates Used in the Dietary Exposure Analyses.**

RAC Food

Forms Blending

Classif i

cation 1 Data

Source 2 Number

of Samples Detectable Residues Non

- Detectable Residues %CT 3 Processing Factors 4 Anticipated Residue

Estimates/Tolerance 5 **Factor for**  **Metabolite 6** 

Number [ Percent] Max

(ppm) Average

(ppm) Number Max.

LOD /LOQ (ppm) Acute Chronic

**Mem bers of Bulb Vegetable (Crop Group 3)**  Onion, bulb, subgroup 3

- 07A bulb NB Tolerance Not Applicable (N/A) 100 DEEM default Tolerance 0.02 ppm None.
dried B

**Mem bers of Leafy Vegetables (except**  **Brassica Vegetables) (Crop Group 4)**  Spinach vegetable PB or NB Tolerance Not Applicable (N/A) 100 DEEM default Tolerance 0.02 ppm None.

**Mem bers of**  **Brassica (Cole) Leafy Vegetables (Crop Group 5)**  Head and Stem, subgroup 5

- A vegetable PB or NB Tolerance Not Applicable (N/A) 100 DEEM default Tolerance 0.02 ppm None.

**Mem bers of Legume Vegetables (Crop Group 6)**  Soybean seed B Tolerance Not Applicable (N/A) max. 2.5 ave. 1 DEEM default Tol erance 0.1 ppm None. milk flour oil Dried beans seed 100 Chickpea flour Dried peas seed FT 45428201 Not Applicable (N/A) Threshold of Regulation (TOR) decision (PP#1E6323 ; D343139, D. Davis, 8/29/07 )

. No tolerance esta

blished under 180.2010. Maximum residues in/on seed estimated at 0.01 ppm ( LOQ ) ; Used 0.005 ppm (1⁄2LOQ) None. Estimate includes all residues of

concern.

**Mem bers of Cucurbit Vegetables (Crop Group 9)**  Cantaloupe 11 fruit PB or NB PD P

2012 2011 2010 1482 5 [ <1 %] 0.12 0.0662 1477 0.01 100 DEEM default RDF#4 PD P Average 0.0052 ppm9 1.8x

All Others Tolerance Not Applicable (N/A) Tolerance 0.02 ppm None. Pumpkin seed B

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Page 19 of 47 **Table 1**  **. Data and Residue Estimates Used in the Dietary Exposure Analyses.**

RAC Food

Forms Blending

Classif i

cation 1 Data

Source 2 Number

of Samples Detectable Residues Non

- Detectable Residues %CT 3 Processing Factors 4 Anticipated Residue

Estimates/Tolerance 5 **Factor for**  **Metabolite 6** 

Number [ Percent] Max

(ppm) Average

(ppm) Number Max.

LOD /LOQ (ppm) Acute Chronic

**Citrus Fruits (Crop Group 10)** Orange fruit PB or NB PD P

2010 2009 1488 874 [ 59 % ] 0.38 0.048372 614 0.01

100 DEEM default RDF#9 PD P Average 0.0305 ppm9 None. Post

harvest Use.

Citron, Citron hybrids, Tangerine, Kumquat, Lemon, Lime, Grapefruit, Pummelo Translate PDP Orange Fruit Data

Orange Juice juice PB PD P 2012 2011 2010 1106 98 [ 9 % ] 0.051 0.015694 1008 0.03 1.0; using PD P juice data RDF#8 PD P Average 0.0151 ppm9

Tangerine, Lemon, Lime, Grapefruit Translate PDP Orange Juice Data

Orange Lemon peel PB Tolerance Not Applicable (N/A) 3.3 12 Tolerance 10.0 ppm

Citrus oil B Tolerance Not Applicable (N/A) DEEM default Tolerance 15.0 ppm

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 20 of 47 **Table 1**  **. Data and Residue Estimates Used in the Dietary Exposure Analyses.**

RAC Food

Forms Blending

Classif i

cation 1 Data

Source 2 Number

of Samples Detectable Residues Non

- Detectable Residues %CT 3 Processing Factors 4 Anticipated Residue

Estimates/Tolerance 5 **Factor for**  **Metabolite 6** 

Number [ Percent] Max

(ppm) Average

(ppm) Number Max.

LOD /LOQ (ppm) Acute Chronic

**Pome Fruits (Crop Group 11)** Apple fruit PB or NB PD P

2010 2009 1488 1162 13 [ 78 %] 7.4 0.350579 326 0.003

100 DEEM default RDF#2 PD P Average 0.2741 ppm9 None. Post

harvest Use.

juice PB PD P 2012 2008 2007 610 183 [ 30 %] 0.32 0.060123 427 0.003 1.0; using PD P juice data RDF#1 PD P Average 0.0191 ppm9

sauce PB PD P 2006 744 289 [39%] 1.2 0.094191 455 0.03 DEEM default RDF# 17 PD P Average 0.0458 ppm9

sauce

baby food PB PD P 2012 396 0

-- -- 396 0.003 PD P Maximum/Average 0.0015 ppm (1⁄2LOD) dried B Translate PDP Apple Fruit Data DEEM Default 8.0 PD P Average 0.2741 ppm9

Pear, Crabapple, Goji berry, Loquat, Quince fruit PB or NB Translate PDP Apple Fruit Data

Note: Older PDP Pear Fruit data (2003

- 2005; 66% detectable residues and having average residue value (Ave. 0.36 ppm) similar to the average residue value in/on apple (Ave. 0.39 ppm) during same time period (2004

- 2005) ) were not used and the newer PDP Pear Fruit data (2009 and 2010) did not include analysis for thiabendazole. DEEM default RDF#2 PD P Average 0.2741 ppm9

Pear baby food PB PD P 2011 2010 776 177 [ 23 %] 0.90 0.025698 599 0.001 RDF#10 PD P Average 0.0062 ppm9

juice PB Translate PD P Apple Juice Data RDF#1 PD P Average 0.0191 ppm9 dried B Translate PDP Apple Fruit Data DEEM d efault 6.25 PD P Average 0.2741ppm9

**Mem bers of**  **Berries ( Crop Group 13**  **)** Strawberry 11 fruit PB PD P 2009 2008 981 11 [ 1 %] 0.14 0.027773 970 0.03 100 DEEM default RDF#11 PD P Average 0.0151 ppm9 1.8x

juice Translate PDP Strawberry Fruit Data

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 21 of 47 **Table 1**  **. Data and Residue Estimates Used in the Dietary Exposure Analyses.**

RAC Food

Forms Blending

Classif i

cation 1 Data

Source 2 Number

of Samples Detectable Residues Non

- Detectable Residues %CT 3 Processing Factors 4 Anticipated Residue

Estimates/Tolerance 5 **Factor for**  **Metabolite 6** 

Number [ Percent] Max

(ppm) Average

(ppm) Number Max.

LOD /LOQ (ppm) Acute Chronic

**Mem bers of**  **Cereal Grains ( Crop Group 15**  **)** Corn, field grain B Tolerance at LOQ (0.01 ppm) Not Applicable (N/A) 100 DEEM default; no longer includes 1.5 for
sy rup (DESAC 1/23/14) Tolerance (0.01 ppm) at

LOQ; Used 0.005 ppm (1⁄2LOQ) None. flour
germ bran starch
sy rup oil Corn, pop grain Corn, sweet grain PB or NB Wheat grain B Tolerance 48996703 Not Applicable (N/A) max. 2.5 ave. 1 DEEM default Recommended Lower

Tolerance in/on Grain (from 1.0 to 0.05 ppm) 14 ; Used 0.05 ppm. Residues do not concentrate in processed commodities None. Estimate includes all residues of

concern. flour
germ bran Triticale flour B Translate Wheat flour 100
Barley all food

forms B Tolerance Not Applicable (N/A) 100 DEEM default Tolerance 0.05 ppm None.

Oat

Rye

**Mem bers of**  **Edible Fungi ( Crop Group 21**  **)** Mushrooms fungus PB PD P 2012 2011 930 494 [ 53 %] 3.9 0.344241 436 0.003 100 DEEM default RDF#14 PD P Average 0.1836 ppm9 1.8x

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 22 of 47 **Table 1**  **. Data and Residue Estimates Used in the Dietary Exposure Analyses.**

RAC Food

Forms Blending

Classif i

cation 1 Data

Source 2 Number

of Samples Detectable Residues Non

- Detectable Residues %CT 3 Processing Factors 4 Anticipated Residue

Estimates/Tolerance 5 **Factor for**  **Metabolite 6** 

Number [ Percent] Max

(ppm) Average

(ppm) Number Max.

LOD /LOQ (ppm) Acute Chronic

**Other Fruit and Vegetables** Avocado 11 fruit NB PD P 2012 372 0

-- -- 372 0.003 100 DEEM default PD P Maximum/Average

0.0015 ppm (1⁄2LOD) 1.8x

Banana fruit PB or NB PD P

2012 2007 2006 2045 1228 [ 60 %] 0.74 0.036729 817 0.03 100 DEEM default RDF#3 PD P Average 0.0280 ppm9 None. Post

harvest Use.

baby food PB or

NB Translate PDP Banana Fruit Data

dried B Translate PDP Banana Fruit Data DEEM Default 3.9 PD P Average 0.0280 ppm9

Mango fruit NB PD P 2010 372 58 1.5 0.472259 314 0.01 100 DEEM default RDF#13 PD P Average 0.0779 ppm9 baby food PB Translate PDP Mango Fruit Data dried NB juice PB Papaya fruit PB or NB PD P

2012 2011 749 26 [ 3 %] 0.505 0.242115 723 0.15 100 DEEM default RDF#15 PD P Average 0.0808 ppm9

baby food PB Translate PDP Papaya Fruit Data RDF#15 PD P Average 0.0808 9
dried B DEEM d efault 1.8 PD P Average 0.0808 ppm9

juice PB DEEM d efault 1.5 RDF#15 PD P Average 0.0808 ppm9

Pla ntain fruit PB or NB Translate PDP Banana Fruit Data 100 DEEM default RDF#3 PD P Average 0.0280 ppm9 dried B DEEM d efault 3.9 PD P Average 0.0280 ppm9

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 23 of 47 **Table 1**  **. Data and Residue Estimates Used in the Dietary Exposure Analyses.**

RAC Food

Forms Blending

Classif i

cation 1 Data

Source 2 Number

of Samples Detectable Residues Non

- Detectable Residues %CT 3 Processing Factors 4 Anticipated Residue

Estimates/Tolerance 5 **Factor for**  **Metabolite 6** 

Number [ Percent] Max

(ppm) Average

(ppm) Number Max.

LOD /LOQ (ppm) Acute Chronic

**Meat and**  **Milk** Fat, except beef (including pork skin) Feeding Study (MRID 40271707) and supported by metabolism data. These estimates which are based on exposure to thiabendazole

- treated feedstuffs will also cover anticipated residues of thiabendazole in these tissues from the use of thiabendazole as an animal drug regulated by FDA. DEEM default Maximum Residues

0.005 ppm None. Estimate includes all residues of

concern. Kidney and meat byproducts Maximum Residues 0.2 ppm Liver Maximum Residues 0.07 ppm Meat, except beef Maximum Residues 0.001 ppm Milk PD P and FT and supported by metabolism data. There are extensive PDP data available for milk (2004

- 2005) which found no detectable residues of thiabendazole (< 0.001 ppm) in 1485 samples and for heavy cream (2007) which found no detectable residues of thiabendazole (<0.008 ppm) or 5

- hydroxythiabendazole (<0.025 ppm) in 742 samples. [Note: Heavy cream samples from 2005 and all milk samples were not analyzed for residues of 5

- hydroxythiabendazole.] Milk samples were not analyzed of residues of 5

- hydroxythiabendazole; however, based on the cattle feeding study (MRID 40271707), residues of 5

- hydroxythiabendazole (free and conjugated) could be estimated at an order of magnitude greater that parent. Hence, the estimated combined residues of parent and 5

- hydroxythiabendazole (free and conjugated) in milk would be < 0.01 ppm. Based on available metabolism data, residues of benzimidazole are not expected in milk. Max im um Residues 0.01 ppm

Beef, fat FDA Tolerance under 21 CFR 556.730 as prescribed under 21 CFR 558.615. These estimates which are based on exposure to thiabendazole used as an animal drug regulated by FDA will also cover anticipated residues of thiabendazole in these tissues from exposure to thiabendazole

- treated feedstuffs. Tolerance (0.1 ppm) at LOQ; Used 0.05 ppm (1⁄2LOQ). Beef, meat Beef dried DEEM Default 1.92 1. Blending Classification: blended (B), partially blended (PB), not blended (NB). 2. Data Source: USDA Pesticide Data Program (PDP) with years included, field trial data (FT) with MRID included, tolerance (Tol ). 3

. Percent Crop Treated (%CT or PCT) based on Screening Level Estimates of Agricultural Uses (SLUA) for Thiabendazole (060101) dated 2/22/13 for reporting timeframe 2004

- 2011. Only available for seed treatment uses on potatoes, soybeans, and wheat. Note: The %CT for seed treatment use on potato is not u seful since there is also a post harvest (PH) use on potato which is the basis for the tolerance in/on potato. 4. Unless otherwise noted used DEEM default processing factors. 5. RDF = Residue Distribution File. See Attachment 2 for details. Except where noted, n on

- detectabl e residues were assigned a value equal to 1⁄2 the method limit of detection (LOD) for USDA PD P data or 1⁄2 the method limit of quantitation (LOQ) for field trial data

. 6. Because USDA PDP monitoring data did not include benzimidazole (free and conjugated), an additional factor
, based on available metabolism data reflecting foliar use, was applied to sweet potato/yam, avocado, cantaloupe, strawberry and mushrooms to account for this residue. Based on re

- evaluation of the available foliar metabolism data, the reviewer has determined that total thiabendazole residues of concern in soybean (foliage, immature plant, straw and seed), sugar beet roots, sugar beet tops and wheat (foliage, forage, straw and grain) may be estimated by

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 24 of 47 multiplying the thiabendazole residue level by 1.5x, 1.4x, 1.8x and 1.8x, respectively. The factor applied to sweet potato/yam (seed piece uses) was based on sugar beet root metabolism data (1.4x) and the factor applied to avocado, cantaloupe, strawberry and mushrooms was based on the maxi mum factor identified in any of the metabolism studies (1.8x). [Note: There are no U.S. registered uses on avocado, cantaloupe, and strawberry. While the tolerances in/on these commodities would suggest post harvest uses, the USDA PDP data found very lo w levels of detects and frequency of detects.] Post harvest treatments are expected to result in the highest potential residues of thiabendazole per se in/on plant commodities and potential residues of benzimidazole (free and conjugated) are unlikely to c ontribute significantly to the total thiabendazole residues of concern in these cases. Hence, an additional factor was not needed for post harvest uses . An additional factor was not needed for tolerances which include all residues of concern. 7. Tolerances in/on sugar beet commodities expired 10/25/10 and there are no currently registered uses of thiabendazole on sugar beets (email dated 1/7/14 from R . Jones (PRD) to J. Kidwell (HED))

. 8. Not e that maximum detect residue level (0.004 ppm) is lower than maximum LOD (0.03 ppm). 9

. Average USDA PDP Residue Calculations: 

### Apple Fruit. ((1162 x 0.350579 ppm) + (326 x 0.0015 ppm (1⁄2LOD))) ÷ 1488 = 0.2741 ppm Apple Juice. ((183 x 0.060123 ppm) + (427 x 0.0015 ppm (1⁄2LOD))) ÷ 610 = 0.0191 ppm Apple Sauce. (( 289 x 0.0 94191 ppm) + ( 455 x 0.015 ppm (1⁄2LOD))) ÷ 744 = 0. 0458 ppm Banana Fruit. ((1228 x 0.036729 ppm) + (817 x 0.015 ppm (1⁄2LOD))) ÷ 2045 = 0.0280 ppm Cantaloupe Fruit. ((5 x 0.0662 ppm) + (1477 x 0.005 ppm (1⁄2LOD))) ÷ 1482 = 0.0052 ppm Carrot Root. ((6 x 0.002567 ppm) + (1482 x 0.015 ppm (1⁄2LOD))) ÷ 1488 = 0.0149 ppm Mango Fruit. ((58 x 0.472259 ppm) + (314 x 0.005 ppm (1⁄2LOD))) ÷ 372 = 0.0779 ppm Mushrooms Fruit. ((494 x 0.344241 ppm) + (436 x 0.0015 ppm (1⁄2LOD))) ÷ 930 = 0.1836 ppm Orange Fruit. ((874 x 0.048372 ppm) + (614 x 0.005 ppm (1⁄2LOD))) ÷ 1488 = 0.0305 ppm Orange Juice. ((98 x 0.015694 ppm) + (1008 x 0.015 ppm (1⁄2LOD))) ÷ 1106 = 0.0151 ppm Papaya Fruit. ((26 x 0.242115 ppm) + (723 x 0.075 ppm (1⁄2LOD))) ÷ 749 = 0.0808 ppm Pear Baby Food. ((177 x 0.025698 ppm) + (599 x 0.0005 ppm (1⁄2LOD))) ÷ 776 = 0.0062 ppm Potato Tuber. ((114 x 0.195919 ppm) + (1374 x 0.015 ppm (1⁄2LOD))) ÷ 1488 = 0.0289 ppm Straw berry Fruit. ((11 x 0.027773 ppm) + (970 x 0.015 ppm (1⁄2LOD))) ÷ 981 = 0.0151 ppm Sweet Potato Tuber. ((8 x 0.006125 ppm) + (1468 x 0.005 ppm (1⁄2LOD))) ÷ 1476 = 0.0050 ppm 10 Post Harvest use on pot ato. Residues of thiabendazole did not concentrate in potato flakes, chips and wet peel (MRID 42660302; D189323, 8/3/93, J. Abbotts and MRID 43531002; D214188, 1/12/99, S. Mason). 11. Not registered for use in the U.S. USDA PDP data were used to estimate residues in/on these commodities. Did not exclude domestic samples from the analyses since domestic samples may also be co nsumed and did not estimate residue in/on domestic samples at nil. All domestic and non

- domestic samples with non

- detectable residues were handled in the same manner

. 12

. Post harvest use on citrus suggests that most of the residues are in/on the peel; hence, the maximum theoretical concentration factor for citrus peel (3.3x) was applied to the tolerance. 13

. Three tolerance

- exceeding residues: (1) 7.4 ppm Chile 2010, (2) 5.9 ppm and 5.7 ppm Washington State 2009 1 4

. The revised Residue Chemistry Chapter to the RED (D267871, 9/7/00, T. Morton) recommended lowering tolerance in/on wheat to 0 .2 ppm. Residues of concern were <0.15 ppm in/on wheat grain from 1x seed treatment study (D2078 50, 1/8/99, S. Mason) conducted at 3.6 oz ai/100 lb seed . Residues of concern were <0.1 ppm in grain, dust, bran, middlings, shorts, red dog, low grade flour and patent flower from study conducted at an exaggerated rate and used to determine residues in p rocessed commodities

. New wheat field trial and processing data (MRID 48996703) have been submitted (Petition 3 F8166; D410807/D410833/D313507, S. Hummel , 2/25/14 ). In wheat grown from seed treated with thiabendazole at 0.08

- 0.14 lb ai/A (90

- 157 g ai/ha)
, residues of thiabendazole and benzimidazole were each below the LOQ (<0.01 ppm) in/on wheat grain; combined residues were <0.02 ppm in/on all samples of wheat grain

. Residues did not concentration in wheat grain processed commodities (bran, flour, middli ngs, shorts, and germ)

. HED has recommended that the current tolerance in/on wheat grain be lowered from 1.0 ppm (established for foliar uses that no longer exist) to 0.05 ppm.

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 25 of 47 

## Attachment 2. **Residue Distribution Files for the Acute Analyses**

RDF#17 Apple Sauce PD P 2006 TotalZ=0 TotalLOD=455 LODRES=0.015 RDF#1 Apple Juice PD P 20 07 2008 20 12 TotalZ=0 TotalLOD=427 LODRES=0.0015 1.2 0.73 0.68 0.61 0.59 0.58 0.54 0.52 0.5 0.46 0.46 0.45 0.36 0.36 0.35 0.35 0.35 0.35 0.35 0.35 0.34 0.34 0.33 0.32 0.32 0.32 0.31 0.31 0.31 0.31 0.3 0.29 0.28 0.28 0.27 0.26 0.26 0.26 0.24 0.23 0.23 0.22 0.22 0.22 0.21 0.21 0.21 0.21 0.2 0.2 0.2 0.19 0.19 0.19 0.18 0.18

0.18 0.18 0.18 0.17 0.17 0.17 0.17 0.16 0.15 0.15 0.15 0.15 0.14 0.14 0.14 0.14 0.14 0.13 0.13 0.13 0.13 0.13 0.13 0.13 0.13 0.12 0.12 0.12 0.11 0.11 0.11 0.099 0.097 0.089 0.088 0.088 0.087 0.084 0.083 0.078 0.075 0.074 0.073 0.073 0.069 0.064 0.06 0.06 0.059 0.052 0.052 0.05 0.05 0.05 0.05

0.05 0.048 0.048 0.048 0.047 0.046 0.045 0.044 0.044 0.043 0.042 0.041 0.039 0.038 0.038 0.037 0.036 0.035 0.032 0.031 0.031 0.03 0.03 0.03 0.029 0.027 0.026 0.024 0.024 0.023 0.021 0.021 0.02 0.02 0.02 0.018 0.018 0.018 0.017 0.016 0.016 0.016 0.015 0.015 0.014 0.014 0.013 0.013 0.013 0.011 0.011 0.011 0.011 0.01 0.01

0.01 0.0097 0.0096 0.0095 0.0091 0.009 0.0083 0.0081 0.0081 0.008 0.0079 0.0074 0.0073 0.0071 0.0069 0.0068 0.0067 0.0067 0.0065 0.0063 0.0063 0.0058 0.0055 0.0055 0.0054 0.0052 0.005 0.0049 0.0048 0.0046 0.0046 0.0045 0.0042 0.0042 0.0036 0.0036 0.0035 0.0035 0.0035 0.0034 0.0033 0.0033 0.0031 0.003 0.003 0.003 0.003 0.0029 0.0027 0.0025 0.0023 0.0022 0.002 0.002 0.002

0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.0019 0.0015 0.0015 0.0014 0.0012 0.001 0.001 0.0009 0.0009 0.0008 0.0008 0.0008 0.0007 0.0007 0.0007 0.0006 0.0006 0.0005 0.0005 0.0005 0.0005 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002

0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.46

0.32 0.32 0.3 0.3 0.28 0.27 0.26 0.26 0.25 0.25 0.24 0.23 0.22 0.21 0.21 0.2 0.2 0.19 0.18 0.18 0.18 0.18 0.17 0.17 0.17 0.16 0.16 0.14 0.14 0.13 0.13 0.13 0.12 0.11 0.11 0.11 0.1 0.094 0.093 0.089 0.087 0.086 0.081 0.08 0.078 0.076 0.074 0.074 0.072 0.071 0.071 0.07 0.067 0.06 0.06

0.055 0.054 0.053 0.051 0.049 0.044 0.043 0.038 0.038 0.037 0.034 0.034 0.033 0.032 0.032 0.032 0.03 0.03 0.029 0.028 0.028 0.028 0.027 0.027 0.027 0.026 0.025 0.025 0.024 0.024 0.024 0.024 0.023 0.021 0.021 0.02 0.02 0.019 0.019 0.018 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.016 0.016 0.016 0.015 0.014 0.014 0.013

0.013 0.013 0.012 0.011 0.01 0.01 0.01 0.01 0.0099 0.009 0.009 0.0089 0.0086 0.0086 0.008 0.008 0.008 0.0072 0.007 0.007 0.007 0.007 0.007 0.0067 0.0062 0.006 0.006 0.006 0.006 0.006 0.006 0.006 0.0058 0.0056 0.0056 0.0054 0.005 0.005 0.005 0.005 0.0044 0.0043 0.004 0.004 0.004 0.004 0.004 0.004 0.0037 0.0036 0.003 0.003 0.003 0.002 0.002

0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 26 of 47 RDF #14 ; Mushrooms; PDP 2011 and 2012 TotalZ=0 TotalLOD=436 LODRES=0.0015 3.9 2.1 2 1.9 1.8 1.8 1.8 1.8 1.5 1.5 1.5 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.1 1.1 1.1 1.1 1 1 1 1 1 0.99 0.97 0.96 0.93 0.92 0.91 0.91 0.9 0.9 0.88 0.88 0.87 0.87 0.86 0.85 0.85 0.83 0.83 0.82 0.81 0.81 0.81 0.8 0.8 0.8 0.8 0.79 0.77

0.75 0.74 0.74 0.74 0.73 0.72 0.72 0.72 0.71 0.71 0.7 0.7 0.69 0.68 0.68 0.68 0.67 0.67 0.67 0.66 0.66 0.66 0.66 0.64 0.64 0.64 0.64 0.64 0.63 0.62 0.62 0.61 0.6 0.6 0.59 0.59 0.59 0.59 0.59 0.59 0.58 0.58 0.58 0.57 0.57 0.57 0.57 0.56 0.55 0.55 0.54 0.54 0.54 0.52 0.52

0.52 0.52 0.51 0.51 0.51 0.5 0.5 0.49 0.49 0.49 0.49 0.49 0.49 0.49 0.49 0.49 0.47 0.46 0.46 0.46 0.46 0.46 0.46 0.45 0.44 0.43 0.43 0.43 0.42 0.42 0.42 0.42 0.41 0.41 0.41 0.4 0.4 0.4 0.39 0.39 0.39 0.39 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.37 0.37 0.37 0.37 0.37 0.37

0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.35 0.35 0.35 0.35 0.35 0.34 0.34 0.34 0.34 0.33 0.33 0.33 0.33 0.32 0.32 0.32 0.31 0.31 0.31 0.31 0.31 0.31 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.297 0.29 0.29 0.29 0.29 0.29 0.28 0.28 0.28 0.28 0.28 0.28 0.28 0.28 0.28 0.27 0.27 0.27

0.27 0.27 0.26 0.26 0.26 0.26 0.26 0.26 0.25 0.25 0.25 0.25 0.25 0.25 0.25 0.25 0.25 0.24 0.24 0.24 0.24 0.24 0.24 0.23 0.23 0.23 0.22 0.22 0.22 0.22 0.22 0.22 0.22 0.21 0.21 0.21 0.21 0.21 0.21 0.21 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.19 0.19 0.19 0.19 0.19 0.18

0.18 0.18 0.18 0.18 0.18 0.18 0.18 0.18 0.17 0.17 0.17 0.17 0.17 0.17 0.17 0.16 0.16 0.16 0.16 0.16 0.16 0.16 0.16 0.16 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.14 0.14 0.14 0.14 0.14 0.14 0.14 0.13 0.13 0.13 0.13 0.13 0.13 0.13 0.13 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12

0.12 0.12 0.11 0.11 0.11 0.11 0.11 0.11 0.1 0.1 0.1 0.1 0.1 0.1 0.099 0.096 0.091 0.09 0.09 0.089 0.088 0.086 0.086 0.084 0.083 0.083 0.082 0.082 0.081 0.081 0.077 0.076 0.076 0.076 0.076 0.074 0.074 0.074 0.072 0.071 0.07 0.07 0.07 0.066 0.065 0.065 0.064 0.064 0.062 0.062 0.062 0.061 0.061 0.06 0.059

0.059 0.059 0.058 0.058 0.057 0.056 0.056 0.056 0.056 0.055 0.055 0.053 0.053 0.051 0.05 0.05 0.05 0.049 0.048 0.048 0.048 0.047 0.046 0.046 0.044 0.042 0.042 0.042 0.041 0.041 0.04 0.04 0.039 0.039 0.038 0.037 0.037 0.036 0.036 0.035 0.034 0.034 0.034 0.033 0.033 0.032 0.032 0.031 0.03 0.03 0.03 0.029 0.029 0.029 0.028

0.027 0.027 0.026 0.026 0.025 0.024 0.024 0.024 0.022 0.022 0.022 0.022 0.021 0.019 0.016 0.015 0.015 0.015 0.014 0.014 0.013 0.011 0.011 0.01 0.009 0.008 0.007 0.007 0.006 0.006 0.006 0.006 0.005 0.005 0.005 0.005 0.005 0.004 0.004 0.004 0.004 0.004 0.004 0.003 0.003 0.003 0.003 0.003 0.003 0.003 0.003 0.003 0.003

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 27 of 47 RDF#9 ; Oranges, PDP 2009 and 2010 TotalZ=0 TotalLOD=614 LODRES=0.005 0.38 0.36 0.31 0.3 0.3 0.3 0.3 0.29 0.28 0.27 0.25 0.24 0.24 0.24 0.24 0.24 0.24 0.24 0.23 0.23 0.23 0.21 0.21 0.21 0.21 0.2 0.2 0.19 0.19 0.19 0.19 0.19 0.19 0.19 0.19 0.18 0.18 0.18 0.18 0.17 0.17 0.17 0.17 0.16 0.16 0.16 0.16 0.159 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.149 0.14

0.14 0.14 0.14 0.14 0.14 0.13 0.13 0.13 0.13 0.13 0.13 0.13 0.13 0.13 0.13 0.13 0.13 0.126 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.11 0.11 0.11 0.11 0.11 0.11 0.11 0.11 0.1 0.1 0.1 0.098 0.097 0.097 0.097 0.097 0.097 0.097 0.096 0.096 0.095 0.095 0.095 0.094 0.094 0.093 0.093 0.092

0.091 0.091 0.091 0.09 0.09 0.089 0.089 0.088 0.088 0.088 0.087 0.083 0.083 0.083 0.081 0.081 0.081 0.08 0.08 0.079 0.079 0.079 0.079 0.078 0.078 0.078 0.078 0.078 0.077 0.077 0.077 0.077 0.077 0.076 0.076 0.076 0.076 0.076 0.075 0.075 0.074 0.073 0.073 0.071 0.071 0.071 0.071 0.07 0.07 0.07 0.069 0.069 0.069 0.067 0.067 0.067 0.067 0.066 0.066

0.065 0.065 0.065 0.064 0.064 0.064 0.063 0.063 0.063 0.062 0.062 0.062 0.062 0.062 0.062 0.062 0.061 0.061 0.061 0.061 0.06 0.06 0.06 0.06 0.059 0.059 0.059 0.059 0.059 0.059 0.058 0.058 0.057 0.057 0.057 0.057 0.056 0.056 0.056 0.056 0.055 0.055 0.054 0.054 0.053 0.053 0.053 0.053 0.053 0.053 0.053 0.053 0.053 0.052 0.052 0.051 0.051 0.051 0.051

0.051 0.051 0.051 0.05 0.05 0.05 0.049 0.049 0.049 0.048 0.048 0.048 0.048 0.048 0.048 0.048 0.047 0.047 0.047 0.047 0.047 0.047 0.046 0.046 0.046 0.046 0.046 0.046 0.046 0.045 0.045 0.045 0.045 0.045 0.045 0.044 0.044 0.044 0.044 0.044 0.043 0.043 0.043 0.043 0.043 0.043 0.042 0.042 0.042 0.042 0.042 0.042 0.042 0.042 0.041 0.041 0.041 0.04 0.04

0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.039 0.039 0.039 0.039 0.039 0.039 0.039 0.039 0.039 0.039 0.039 0.039 0.039 0.038 0.038 0.038 0.038 0.038 0.038 0.038 0.038 0.038 0.038 0.038 0.038 0.038 0.038 0.037 0.037 0.037 0.037 0.037 0.037 0.037 0.037 0.037 0.037 0.037 0.036 0.036 0.036 0.036 0.036 0.036 0.036 0.036 0.036 0.035 0.035 0.035

0.035 0.035 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.033 0.033 0.033 0.033 0.033 0.033 0.033 0.033 0.033 0.033 0.033 0.033 0.033 0.033 0.032 0.032 0.032 0.032 0.032 0.032 0.032 0.032 0.032 0.032 0.032 0.032 0.032 0.032 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.031

0.031 0.031 0.031 0.031 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.029 0.029 0.029 0.029 0.029 0.029 0.029 0.029 0.029 0.029 0.029 0.029 0.029 0.029 0.028 0.028 0.028 0.028 0.028 0.028 0.028 0.028 0.028 0.028 0.028 0.028 0.028 0.028 0.027 0.027 0.027 0.027 0.027 0.027 0.027 0.027 0.027 0.027 0.027 0.026

0.026 0.026 0.026 0.026 0.026 0.026 0.026 0.026 0.026 0.026 0.026 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.024 0.024 0.024 0.024 0.024 0.024 0.024 0.024 0.024 0.024 0.024 0.024 0.024 0.023 0.023 0.023 0.023 0.023 0.023 0.023 0.023 0.023 0.023 0.023 0.023 0.023 0.023 0.023 0.023 0.023 0.022 0.022 0.022 0.022 0.022

0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02

0.02 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018

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### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 28 of 47 RDF#9 ; Oranges; PDP Continued from previous page TotalZ=0 TotalLOD=614 LODRES=0.005 0.018 0.018 0.018 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015

0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013

0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011

0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005

0.005 0.005 0.005

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 29 of 47 RDF#2 ; A

pples ; PDP 2009 and 2010 TotalZ=0 TotalLOD=326 LODRES=0.0015 7.4 5.9 5.7 4.6 4.3 4.1 3.9 3.4 3.3 3.124 3.1 3.1 3 3 2.6 2.6 2.5 2.5 2.4 2.4 2.4 2.3 2.3 2.3 2.23 2.2 2.2 2.1 2.1 2.1 2 2 2 1.9 1.9 1.9 1.884 1.82 1.8 1.8 1.8 1.8 1.8 1.7 1.7 1.7 1.7 1.7 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5

1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.48 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.25 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.13 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1

1.1 1.1 1 1 1 1 1 0.97 0.97 0.96 0.96 0.96 0.96 0.95 0.95 0.946 0.94 0.94 0.92 0.91 0.91 0.9 0.9 0.9 0.89 0.87 0.87 0.86 0.86 0.85 0.85 0.85 0.84 0.84 0.83 0.83 0.83 0.83 0.83 0.82 0.82 0.82 0.81 0.81 0.81 0.8 0.8 0.8 0.791 0.79 0.79 0.79 0.79 0.78 0.77 0.77 0.77 0.764 0.76

0.76 0.76 0.75 0.75 0.74 0.74 0.74 0.74 0.74 0.73 0.73 0.72 0.72 0.72 0.71 0.71 0.71 0.71 0.7 0.69 0.69 0.69 0.68 0.66 0.66 0.651 0.65 0.65 0.64 0.64 0.64 0.64 0.64 0.63 0.62 0.61 0.61 0.61 0.61 0.59 0.59 0.59 0.59 0.58 0.58 0.57 0.57 0.56 0.56 0.56 0.56 0.56 0.55 0.55 0.55 0.55 0.55 0.55 0.55

0.54 0.54 0.54 0.54 0.53 0.53 0.53 0.52 0.52 0.52 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.51 0.5 0.5 0.49 0.49 0.49 0.49 0.49 0.49 0.49 0.48 0.48 0.48 0.48 0.48 0.48 0.48 0.471 0.47 0.47 0.47 0.47 0.47 0.46 0.456 0.45 0.45 0.45 0.45 0.44 0.44 0.44 0.438 0.43 0.43 0.43 0.43 0.43 0.42

0.42 0.42 0.42 0.41 0.41 0.41 0.41 0.41 0.41 0.4 0.4 0.4 0.4 0.4 0.4 0.4 0.39 0.39 0.39 0.39 0.39 0.39 0.38 0.38 0.38 0.38 0.38 0.38 0.38 0.37 0.37 0.37 0.37 0.37 0.37 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.36 0.35 0.35 0.35 0.35 0.35 0.35 0.34 0.34 0.34 0.34 0.33 0.33

0.33 0.33 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.32 0.317 0.31 0.31 0.31 0.303 0.3 0.3 0.3 0.3 0.3 0.3 0.29 0.29 0.29 0.29 0.29 0.29 0.29 0.28 0.28 0.28 0.28 0.28 0.28 0.28 0.27 0.27 0.27 0.27 0.27 0.27 0.268 0.26 0.26 0.26 0.26 0.26 0.26 0.26 0.26 0.25 0.25 0.25 0.25 0.25 0.25 0.25 0.25 0.25

0.25 0.24 0.24 0.24 0.24 0.24 0.24 0.24 0.24 0.24 0.238 0.232 0.23 0.23 0.23 0.23 0.23 0.22 0.22 0.22 0.22 0.22 0.21 0.21 0.21 0.21 0.21 0.21 0.21 0.21 0.21 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.19 0.19 0.19 0.18 0.18 0.18 0.18 0.18 0.18 0.18 0.178 0.17 0.17 0.17 0.17

0.17 0.17 0.17 0.17 0.17 0.17 0.16 0.16 0.16 0.16 0.16 0.16 0.16 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.14 0.14 0.13 0.13 0.13 0.13 0.13 0.13 0.13 0.13 0.13 0.13 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.11 0.11 0.11 0.11 0.11 0.11 0.11 0.11 0.11

0.1 0.1 0.1 0.1 0.1 0.098 0.098 0.097 0.096 0.096 0.095 0.095 0.094 0.094 0.093 0.093 0.092 0.091 0.0908 0.09 0.089 0.088 0.087 0.082 0.081 0.081 0.08 0.0794 0.074 0.074 0.073 0.072 0.071 0.067 0.066 0.066 0.065 0.062 0.06 0.059 0.058 0.057 0.056 0.054 0.054 0.053 0.052 0.051 0.049 0.049 0.048 0.048 0.0477 0.047 0.044 0.044 0.043 0.042 0.04

0.039 0.039 0.039 0.037 0.035 0.034 0.033 0.032 0.032 0.032 0.032 0.031 0.031 0.031 0.031 0.031 0.031 0.03 0.028 0.028 0.028 0.027 0.027 0.026 0.026 0.026 0.025 0.025 0.025 0.025 0.024 0.024 0.024 0.024 0.024 0.023 0.023

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### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 30 of 47 RDF#2 ; Apples; PDP

- Continued from previous page TotalZ=0 TotalLOD=326 LODRES=0.0015 0.023 0.022 0.022 0.022 0.0219 0.021 0.021 0.021 0.021 0.021 0.02 0.019 0.019 0.018 0.018 0.018 0.018 0.018 0.017 0.017 0.016 0.016 0.016 0.016 0.016 0.016 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.0138 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012

0.012 0.012 0.012 0.012 0.0115 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.0099 0.0097 0.0097 0.0095 0.0095 0.0094 0.0094 0.0093 0.0093 0.0092 0.0092 0.0091 0.0088 0.0086 0.0086 0.0086 0.0085 0.0085 0.0085 0.0084 0.0082 0.0082 0.0081 0.008 0.0079 0.0079 0.0079 0.0079 0.0079 0.0077 0.0077 0.0076 0.0076 0.0076 0.0075

0.0075 0.0075 0.0074 0.0074 0.0074 0.0074 0.0072 0.0072 0.007 0.007 0.0069 0.0069 0.0068 0.0068 0.0066 0.0066 0.0066 0.0066 0.0066 0.0065 0.0065 0.0065 0.0064 0.0064 0.0064 0.0063 0.0061 0.0061 0.006 0.006 0.006 0.006 0.006 0.006 0.0059 0.0059 0.0059 0.0058 0.0057 0.0057 0.0057 0.0057 0.0056 0.0056 0.0055 0.0055 0.0054 0.0054 0.0054 0.0054 0.0054 0.0054 0.0053 0.0052 0.0052 0.0052 0.0051 0.0051 0.0051

0.0051 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.0049 0.0049 0.0049 0.0049 0.0049 0.0048 0.0048 0.0048 0.0048 0.0048 0.0048 0.0047

0.0047 0.0047 0.0047 0.0046 0.0046 0.0046 0.0046 0.0046 0.0046 0.0045 0.0045 0.0045 0.0043 0.0043 0.0043 0.0043 0.0043 0.0043 0.0043 0.0043 0.0043 0.0042 0.0042 0.0042 0.0041 0.0041 0.0041 0.004 0.004 0.004 0.004 0.0039 0.0039 0.0038 0.0038 0.0038 0.0038 0.0037 0.0037 0.0037 0.0037 0.0036 0.0036 0.0035 0.0035 0.0034 0.0034 0.0034 0.0033 0.0033 0.0033 0.0033 0.0032 0.0032 0.0032 0.0032 0.0032 0.0032 0.0032

0.0032 0.0032 0.0031 0.0031 0.0031 0.0031 0.0031 0.0031 0.0031 0.0031 0.0031 0.003 0.003 0.003 0.003 0.003 0.003 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002

0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017

0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017

0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017

0.0017 0.0017

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 31 of 47 RDF#8 ; Orange Juice ; P DP 2010, 2011 and 2012 TotalZ=0 TotalLOD=1008 LODRES=0.015 RDF#10 ; Pears Baby Food; PD P 2010 and 2011 TotalZ=0 TotalLOD=599 LODRES=0.0005 RDF#13 ; Mango; PDP 2010 TotalZ=0 TotalLOD=314 LODRES=0.005 RDF#15 ; Papaya; PD P 2011 and 2012 TotalZ=0 TotalLOD=723 LODRES=0.075 0.051 0.044 0.039 0.038 0.038 0.034 0.031 0.031 0.029 0.029 0.028 0.027 0.026 0.026 0.025 0.025 0.025 0.023 0.022 0.022 0.022 0.021 0.021 0.021 0.021 0.02 0.02 0.02 0.02 0.02 0.02 0.019 0.019 0.019 0.019 0.019 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.017 0.017 0.017 0.017 0.017 0.017 0.016 0.016 0.016 0.015 0.015 0.015 0.014 0.012 0.012

0.012 0.011 0.01 0.01 0.01 0.009 0.009 0.009 0.009 0.007 0.007 0.007 0.007 0.007 0.007 0.006 0.006 0.006 0.006 0.005 0.005 0.004 0.004 0.004 0.004 0.004 0.004 0.004 0.004 0.003 0.003 0.003 0.003 0.003 0.003 0.003 0.003 0.003 0.003 0.9

0.31 0.26 0.19 0.11 0.11 0.093 0.088 0.087 0.086 0.085 0.078 0.067 0.065 0.063 0.06 0.055 0.054 0.052 0.051 0.05 0.046 0.043 0.043 0.043 0.043 0.04 0.04 0.039 0.039 0.038 0.035 0.033 0.032 0.031 0.03 0.03 0.03 0.03 0.029 0.028 0.028 0.028 0.028 0.027 0.027 0.025 0.024 0.024 0.022 0.022 0.019 0.019 0.019 0.018 0.018 0.018 0.018 0.018

0.018 0.017 0.016 0.016 0.016 0.015 0.015 0.015 0.014 0.013 0.013 0.012 0.012 0.011 0.0097 0.0095 0.0084 0.0084 0.0079 0.0079 0.0075 0.0073 0.0071 0.0069 0.0066 0.0063 0.0063 0.0059 0.0055 0.0054 0.005 0.005 0.0044 0.0042 0.0041 0.0039 0.0039 0.0038 0.0032 0.0031 0.0031 0.0031 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002

0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 0.0017 1.5

1.4 1.3 1.3 1.2 1.2 1.2 0.92 0.82 0.79 0.78 0.76 0.76 0.75 0.74 0.65 0.65 0.61 0.59 0.54 0.49 0.47 0.45 0.43 0.41 0.4 0.4 0.37 0.35 0.34 0.31 0.28 0.28 0.27 0.27 0.25 0.25 0.25 0.24 0.22 0.21 0.2 0.19 0.18 0.18 0.16 0.13 0.13 0.13 0.12 0.11 0.09 0.082 0.078 0.074 0.07 0.043 0.024 0.505 0.45 0.45 0.4 0.38 0.34 0.33 0.32 0.28 0.2 0.2 0.19 0.18 0.18 0.17 0.17 0.16 0.16 0.16 0.16 0.16 0.15 0.15 0.15 0.15 0.15

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 32 of 47 RDF#3 ; Banana, PD P 2006, 2007 and 2012 TotalZ=0 T otalLOD=817 LODRES=0.015 0.74 0.36 0.23 0.19 0.18 0.18 0.18 0.17 0.17 0.17 0.17 0.16 0.16 0.16 0.15 0.15 0.14 0.14 0.13 0.13 0.13 0.13 0.13 0.13 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.11 0.11 0.11 0.11 0.11 0.11 0.11 0.11 0.11 0.11 0.11 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.099 0.099 0.099 0.099 0.099 0.098 0.098 0.097

0.097 0.096 0.096 0.096 0.096 0.095 0.095 0.095 0.095 0.094 0.094 0.093 0.093 0.092 0.092 0.092 0.091 0.091 0.091 0.091 0.09 0.09 0.089 0.089 0.088 0.088 0.088 0.088 0.087 0.087 0.087 0.087 0.085 0.085 0.085 0.085 0.084 0.084 0.083 0.083 0.083 0.083 0.082 0.082 0.082 0.082 0.081 0.081 0.08 0.079 0.078 0.078 0.078 0.077 0.077 0.077 0.077 0.077 0.076

0.076 0.075 0.075 0.075 0.075 0.074 0.074 0.074 0.073 0.073 0.073 0.073 0.073 0.073 0.073 0.072 0.072 0.072 0.071 0.071 0.07 0.07 0.07 0.069 0.069 0.068 0.068 0.068 0.068 0.068 0.068 0.068 0.067 0.067 0.067 0.067 0.067 0.067 0.066 0.066 0.065 0.065 0.065 0.065 0.065 0.065 0.065 0.064 0.064 0.064 0.064 0.064 0.063 0.063 0.063 0.063 0.063 0.062 0.062

0.062 0.062 0.062 0.061 0.061 0.061 0.061 0.061 0.061 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.059 0.059 0.059 0.059 0.059 0.059 0.059 0.059 0.059 0.058 0.058 0.058 0.058 0.058 0.058 0.058 0.058 0.058 0.058 0.058 0.058 0.058 0.057 0.057 0.057 0.057 0.057 0.057 0.057 0.057 0.057 0.056 0.056 0.056 0.056 0.056 0.056 0.056

0.056 0.056 0.056 0.055 0.055 0.055 0.055 0.054 0.054 0.054 0.054 0.054 0.054 0.054 0.054 0.054 0.054 0.054 0.054 0.054 0.054 0.054 0.054 0.053 0.053 0.053 0.053 0.053 0.053 0.053 0.053 0.052 0.052 0.052 0.052 0.052 0.052 0.051 0.051 0.051 0.051 0.051 0.051 0.051 0.051 0.051 0.051 0.051 0.051 0.051 0.051 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05

0.05 0.049 0.049 0.049 0.049 0.049 0.049 0.049 0.049 0.049 0.049 0.048 0.048 0.048 0.048 0.048 0.048 0.048 0.048 0.048 0.048 0.048 0.047 0.047 0.047 0.047 0.047 0.047 0.047 0.047 0.047 0.047 0.046 0.046 0.046 0.046 0.046 0.046 0.046 0.046 0.045 0.045 0.045 0.045 0.045 0.045 0.045 0.045 0.045 0.045 0.045 0.045 0.045 0.045 0.045 0.045 0.045 0.044 0.044

0.044 0.044 0.044 0.044 0.044 0.044 0.044 0.044 0.044 0.044 0.044 0.044 0.044 0.044 0.044 0.043 0.043 0.043 0.043 0.043 0.043 0.043 0.043 0.043 0.042 0.042 0.042 0.042 0.042 0.042 0.042 0.042 0.042 0.042 0.042 0.042 0.042 0.042 0.041 0.041 0.041 0.041 0.041 0.041 0.041 0.041 0.041 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04

0.04 0.04 0.039 0.039 0.039 0.039 0.039 0.039 0.039 0.039 0.039 0.039 0.039 0.038 0.038 0.038 0.038 0.038 0.038 0.038 0.038 0.038 0.038 0.038 0.037 0.037 0.037 0.037 0.037 0.037 0.037 0.037 0.037 0.037 0.037 0.037 0.037 0.037 0.037 0.037 0.037 0.037 0.037 0.037 0.036 0.036 0.036 0.036 0.036 0.036 0.036 0.036 0.035 0.035 0.035 0.035 0.035 0.035 0.035

0.035 0.035 0.035 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.034 0.033 0.033 0.033 0.033 0.033 0.033 0.033 0.033 0.033 0.033 0.033 0.033 0.033 0.033 0.033 0.033 0.033 0.033 0.033 0.033 0.032 0.032 0.032 0.032 0.032 0.032 0.032 0.032 0.032 0.032 0.032 0.032 0.032 0.032 0.032

0.032 0.032 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.031 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.029 0.029 0.029 0.029 0.029 0.029 0.029 0.029 0.029 0.029 0.029 0.029 0.029 0.029 0.029

0.029 0.029 0.029 0.029 0.029 0.029 0.029 0.029 0.028 0.028 0.028 0.028 0.028 0.028 0.028 0.028 0.028 0.028 0.028 0.028 0.028 0.028 0.028 0.028 0.028 0.028 0.028 0.028 0.027 0.027 0.027 0.027 0.027 0.027 0.027 0.027 0.027 0.027 0.027 0.027 0.027 0.027 0.027 0.027 0.026

Continued
on next page

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 33 of 47 RDF#3 ; Banana; PDP

- Continued from previous page TotalZ=0 T otalLOD=817 LODRES=0.015 0.026 0.026 0.026 0.026 0.026 0.026 0.026 0.026 0.026 0.026 0.026 0.026 0.026 0.026 0.026 0.026 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.025 0.024 0.024 0.024 0.024 0.024 0.024 0.024 0.024 0.024 0.024

0.024 0.024 0.024 0.024 0.024 0.024 0.024 0.024 0.024 0.024 0.024 0.024 0.024 0.024 0.024 0.024 0.024 0.024 0.023 0.023 0.023 0.023 0.023 0.023 0.023 0.023 0.023 0.023 0.023 0.023 0.023 0.023 0.023 0.023 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022 0.022

0.022 0.022 0.022 0.022 0.022 0.022 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.021 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019

0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.019 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.018 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017 0.017

0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.016 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.015 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014

0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.014 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.013 0.012 0.012 0.012 0.012 0.012

0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.012 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011 0.011

0.011 0.011 0.011 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.0099 0.0098 0.0097 0.0097 0.0097 0.0096 0.0095 0.0095 0.0094 0.0093 0.0093 0.0093 0.009 0.009 0.0089 0.0086 0.0085 0.0085 0.0085 0.0083 0.0083 0.0083 0.0081 0.008 0.008 0.008 0.008 0.008 0.0078 0.0078 0.0077 0.0076 0.0076 0.0076 0.0075 0.0074 0.0074 0.0074 0.0074 0.0074 0.0073 0.0073 0.0072 0.0072

0.0071 0.0071 0.007 0.007 0.007 0.0069 0.0069 0.0068 0.0067 0.0067 0.0067 0.0067 0.0067 0.0066 0.0064 0.0064 0.0064 0.0063 0.0062 0.0062 0.0062 0.0062 0.0061 0.0061 0.006 0.0059 0.0059 0.0059 0.0059 0.0058 0.0058 0.0056 0.0055 0.0054 0.0053 0.0052 0.0052 0.0051 0.0051 0.005 0.005 0.005 0.0048 0.0047 0.0046 0.0046 0.0046 0.0046 0.0045 0.0044 0.0044 0.0043 0.0043 0.0043 0.0041 0.004 0.004 0.004 0.0039

0.0039 0.0039 0.0039 0.0038 0.0037 0.0037 0.0035 0.0035 0.0035 0.0035 0.0034 0.0034 0.0033 0.0032 0.003 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002

0.002

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 34 of 47 RDF#4 ; Cantaloupe; PDP 2010, 2011 and 2012 TotalZ=0 TotalLOD=1477 LODRES=0.005 RDF#5 ; Carrot; PDP 2006 and 2007 TotalZ=0 TotalLOD=1482 LODRES=0.015 RDF#7 ; Potato; PDP 2008 and 2009 TotalZ=0 TotalLOD=1374 LODRES=0.015

0.12 0.12 0.06 0.018 0.013 0.004 0.0034 0.002 0.002 0.002 0.002 1.5 1.2 1 1 0.98 0.89 0.84 0.84 0.78 0.72 0.72 0.65 0.65 0.64 0.64 0.62 0.56 0.41 0.35 0.34 0.34 0.34 0.33 0.29 0.28 0.27 0.267 0.266 0.26 0.236 0.234 0.23 0.22 0.21 0.19 0.19 0.16 0.15 0.14 0.14 0.14 0.14 0.12 0.12 0.11 0.1 0.1 0.066 0.062 0.061 0.0501 0.0501 0.0501 0.0501 0.0501

0.0501 0.0501 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.041 0.039 0.03 0.028 0.022 0.021 0.016 0.015 0.013 0.01 0.008 0.008 0.008 0.007 0.007 0.005 0.005 0.005 0.005 0.005 0.005 0.005 0.0049 0.0044 0.0042 0.004 0.004 0.004 0.004 0.004 0.004 0.004 0.004 0.004 0.004 0.0036 0.003 0.003 0.003 0.003 0.003 0.002

0.002 0.002 0.002 0.002 0.002

RDF#11 ; Strawberry; PDP 2008 and 2009 TotalZ=0 TotalLOD=970 LODRES=0.015 RDF#12 : Sweet Potato, PDP 2008, 2009 and 2010 TotalZ=0 TotalLOD=1468 LODRES=0.005 0.14 0.047 0.037 0.022 0.018 0.015 0.009 0.007 0.005 0.0035 0.002 0.014 0.005 0.005 0.005 0.005 0.005 0.005 0.005

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 35 of 47 

## Attachment 3. **Acute Residue Input file**

Filename: 060101ACUTEThiabendazole 3 7 14.R08 Chemical: Thiabendazole RfD(Chronic): .033 mg/kg bw/day NOEL(Chronic): 10 mg/kg bw/day RfD(Acute): .05 mg/kg bw/day NOEL(Acute): 50 mg/kg bw/day Date created/last modified: 03

- 07

- 2014/12:26:09 Program ver. 3.16, 03

- 08

- d

----------------------------------------------------------------------------------- RDL indices and parameters for Monte Carlo Analysis: Index Dist Parameter #1 Param #2 Param #3 Comment # Code

----- ---- ------------ -------- -------- ------- 1 6 Apple Juice.rdf 2 6 Apples.rdf 3 6 Banana.rdf 4 6 Cantaloupe.rdf 5 6 Carrot.rdf 6 6 Frozen Potato.rdf 7 6 Potato.rdf 8 6 Orange Juice.rdf 9 6 Oranges.rdf 10 6 Pears Baby Food.rdf 11 6 Strawberry.rdf 12 6 Sweet Potato.rdf 13 6 Mango.rdf 14 6 Mushrooms.rdf 15 6 Papaya.rdf 16 6 Wheat flour.rdf 17 6 Apple Sauce.rdf

EPA Crop Commodity Name Def Res Adj.Factors RDLComment Code Grp (ppm) #1 #2 Pntr

---------- ---- ------------------------------- ---------- ------ ------ --- ------- 0101050000 1AB Beet, garden, roots 0.020000 1.000 1.000 0101050 001 1AB Beet, garden, roots

- babyfood 0.020000 1.000 1.000 0101067000 1AB Burdock 0.020000 1.000 1.000 0101078000 1AB Carrot 10.000000 1.000 1.000 5 0101078001 1AB Carr ot

- babyfood 0.002000 1.000 1.000 0101079000 1AB Carrot, juice 10.000000 1.000 1.000 5 0101084000 1AB Celeriac 0.020000 1.000 1.000 0101100000 1AB Chicory, roots 0.020000 1.000 1.000 0101168000 1AB Ginseng, dried 0.020000 1.000 1.000 0101190000 1AB Horseradish 0.020000 1.000 1.000 0101250000 1AB Parsley, turnip rooted 0.020000 1.000 1.000 0101251000 1AB Parsnip 0.020000 1.000 1.000 0101251001 1AB Parsnip

- babyfood 0.020000 1.000 1.000 0101314000 1AB Radish, roots 0.020000 1.000 1.000 0101316000 1AB Radish, Oriental, roots 0.020000 1.000 1.000 0101327000 1AB Rutabaga 0.020000 1.000 1.000 0101331000 1AB Salsify, roots 0.020000 1.000 1.0 00 0101388000 1AB Turnip, roots 0.020000 1.000 1.000 0103296000 1C Potato, chips 0.028900 1.000 1.000 Residues Do Not Conc. 0103297000 1C Potato, dry (granules/ flakes) 0.028900 1.000 1.000 Residues Do Not Conc. 0103297001 1C Potato, dry (granules/ flakes)

- b 0.028900 1.000 1.000 Residues Do Not Conc. 0103298000 1C Potato, flour 0.028900 1.000 1.000 Residues Do Not Conc. 0103298001 1 C Potato, flour

- babyfood 0.028900 1.000 1.000 Residu e s Do Not Conc. 0103299000 1C Potato, tuber, w/peel 10.000000 1.000 1.000 7 0103299001 1C Potato, tuber, w/peel

- babyfood 10.000000 1.000 1.000 7 0103300000 1C Potato, tuber, w/o peel 10.000000 1.000 1.000 7 0103300001 1C Potato, tuber, w/o peel

- babyfood 10.000000 1.000 1.000 7 0103366000 1CD Sweet potato 0.050000 1.400 1.000 12 1.4x for benzi midazole 0103366001 1CD Sweet potato

- babyfood 0.001500 1.400 1.000 1.4x for benzimidazole 0103406000 1CD Yam, true 0.050000 1.400 1.000 12 1.4x for benzimidazole 0301165000 3A Garlic, bulb 0.020000 1.000 1.000 0301165001 3A Garlic, bulb

- babyfood 0.020000 1.000 1.000 0301237000 3A Onion, bulb 0.020000 1.000 1.000 0301237001 3A Onion, bulb

- babyfood 0.0 20000 1.000 1.000 0301238000 3A Onion, bulb, dried 0.020000 1.000 1.000 0301238001 3A Onion, bulb, dried

- babyfood 0.020000 1.000 1.000 0301338000 3A Shallot, bulb 0.020000 1.000 1.000 0401355000 4A Spinach 0.020000 1.000 1.000 0401355001 4A Spinach

- babyfood 0.020000 1.000 1.000

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 36 of 47 0501061000 5A Broccoli 0.020000 1.000 1.000 0501061001 5A Broccoli

- babyfood 0.020000 1.000 1.000 0501062000 5A Broccoli, Chinese 0.020000 1.000 1.000 0501064000 5A Brussels sprouts 0.020000 1.000 1.000 0501069000 5A Cabbage 0.020000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 0.020000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 0.020000 1.000 1.000 0501083000 5A Cauliflower 0.020000 1.000 1.000 0501196000 5A Kohlrabi 0.020000 1.000 1.000 0600347000 6 Soybean, seed 0.100000 1.000 0.025 Tol and blended commodity 0 600349000 6 Soybean, soy milk 0.100000 1.000 0.025 Tol and blended commodity 0600349001 6 Soybean, soy milk

- babyfood or in 0.100000 1.000 0.025 Tol and blended commodity 0600350000 6 Soybean, oil 0.100000 1.000 0.025 Tol and blended commodity 0600350001 6 Soybean, oil

- babyfood 0.100000 1.000 0.025 Tol and blended commodity 0603030000 6C Bean, black, seed 0.100000 1.000 1.000 06030320 00 6C Bean, broad, seed 0.100000 1.000 1.000 0603034000 6C Bean, cowpea, seed 0.100000 1.000 1.000 0603035000 6C Bean, great northern, seed 0.100000 1.000 1.000 0603036000 6C Bean, kidney, seed 0.100000 1.000 1.000 0603038000 6C Bean, lima, seed 0.100000 1.000 1.000 0603039000 6C Bean, mung, seed 0.100000 1.000 1.000 0603040000 6C Bean, navy, seed 0.100000 1.000 1.000 0603041000 6C Bean, pink, seed 0.100000 1.000 1.000 0603042000 6C Bean, pinto, seed 0.100000 1.000 1.000 0603098000 6C Chickpea, seed 0.100000 1.000 1.000 0603098001 6C Chickpea, seed

- babyfood 0.100000 1.000 1.000 0603099000 6C Chickpea, flour 0.100000 1.000 1.000 0603182000 6C Guar, seed 0.100000 1.000 1.000 0603182001 6C Guar, seed

- babyfood 0.100000 1.000 1.000 0603203000 6C Lentil, seed 0.005000 1.000 1.000 0603256000 6C Pea, dry 0.005000 1.000 1.000 0603256001 6C Pea, dry

- babyfood 0.005000 1.000 1.000 0603258000 6C Pea, pigeon, seed 0.005000 1.000 1.000 0603348000 6C Soybean, f lour 0.100000 1.000 1.000 0603348001 6C Soybean, flour

- babyfood 0.100000 1.000 1.000 0901075000 9A Cantaloupe 15.000000 1.800 1.000 4 1.8x for benzimidazole 0901187000 9A H oneydew melon 0.020000 1.000 1.000 0901399000 9A Watermelon 0.020000 1.000 1.000 0901400000 9A Watermelon, juice 0.020000 1.000 1.000 0902021000 9B Balsam pear 0.020000 1.000 1.000 0902088000 9B Chayote, fruit 0.020000 1.000 1.000 0902102000 9B Chinese waxgourd 0.020000 1.000 1.000 0902135000 9B Cucumber 0.020000 1.000 1.000 0902308000 9B Pumpkin 0.020000 1.000 1.000 0902309000 9B Pumpkin, seed 0.020000 1.000 1.000 0902356000 9B Squash, summer 0.020 000 1.000 1.000 0902356001 9B Squash, summer

- babyfood 0.020000 1.000 1.000 0902357000 9B Squash, winter 0.020000 1.000 1.000 0902357001 9B Squash, winter

- babyfood 0.020000 1.000 1.000 1001106000 10A Citron 10.000000 1.000 1.000 9 1001107000 10A Citrus hybrids 10.000000 1.000 1.000 9 1001108000 10A Citrus, oil 15.000000 1.000 1.000 1001240000 10A Orange 10.000000 1.000 1.000 9 1001241000 10A Orange, juice 10.000000 1.000 1.000 8 1001241001 10A Orange, juice

- babyfood 10.000000 1.000 1.000 8 1001242000 10 A Orange, peel 10.000000 3.300 1.000 Conc. for peel 1001369000 10A Tangerine 10.000000 1.000 1.000 9 1001370000 10A Tangerine, juice 10.000000 1.000 1.000 8 1002197000 1 0B Kumquat 10.000000 1.000 1.000 9 1002199000 10B Lemon 10.000000 1.000 1.000 9 1002200000 10B Lemon, juice 10.000000 1.000 1.000 8 1002200001 10B Lemon, ju ice

- babyfood 10.000000 1.000 1.000 8 1002201000 10B Lemon, peel 10.000000 3.300 1.000 Conc. f or peel 1002206000 10B Lime 10.000000 1.000 1.000 9 1002207000 10B Lime, juice 10.000000 1.000 1.000 8 1002207001 10B Lime, juice

- babyfood 10.000000 1.000 1.000 8 1003180000 10C Grapefruit 10.000000 1.000 1.000 9 1003181000 10 C Grapefruit, juice 10.000000 1.000 1.000 8 1003307000 10C Pummelo 10.000000 1.000 1.000 9 1100007000 11 Apple, fruit with peel 5.000000 1.000 1.000 2 1100008000 11 Apple, pee led fruit 5.000000 1.000 1.000 2 1100008001 11 Apple, peeled fruit

- babyfood 5.000000 1.000 1.000 2 1100009000 11 Apple, dried 0.274100 8.000 1.000 1100009001 11 Apple, dried

- babyfood 0.274100 8.000 1.000 1100010000 11 Apple, juice 5.000000 1.000 1.000 1

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 37 of 47 1100010001 11 Apple, juice

- babyfood 5.000000 1.000 1.000 1 1100011000 11 Apple, sauce 5.000000 1.000 1.000 17 1100011001 11 Apple, sauce

- babyfood 0.001500 1.000 1.000 1100129000 11 Crabapple 5.000000 1.000 1.000 2 1100173500 11 Goji berry 5.000000 1.000 1.000 2 1100210000 11 Loquat 5.000000 1.000 1.000 2 1100266000 11 Pear 5.000000 1.000 1.000 2 1100266001 11 Pear

- babyfood 5.000000 1.000 1.000 10 1100267000 11 Pear, dried 0.274100 6.250 1.000 1100268000 11 Pear, juice 5.000000 1.000 1.000 1 1100268001 11 Pear, juice

- babyfood 5 .000000 1.000 1.000 1 1100310000 11 Quince 5.000000 1.000 1.000 2 1307359000 13G Strawberry 5.000000 1.800 1.000 11 1.8x for benzimidazole 1307359001 13G Strawberry

- babyfood 5.000000 1.800 1.000 11 1.8x for benzimidazole 1307360000 13G Strawberry, juice 5.000000 1.800 1.000 11 1.8x for benzimidazole 1307360001 13G Strawberry, juice

- babyfood 5.000000 1.800 1.000 11 1.8x for benz imidazole 1500025000 15 Barley, pearled barley 0.050000 1.000 1.000 1500025001 15 Barley, pearled barley

- babyfood 0.050000 1.000 1.000 1500026000 15 Barley, flour 0.050000 1.000 1.000 150 0026001 15 Barley, flour

- babyfood 0.050000 1.000 1.000 1500027000 15 Barley, bran 0.050000 1.000 1.000 1500120000 15 Corn, field, flour 0.005000 1.000 1.000 1500120001 15 Corn, field, flour

- babyfood 0.005000 1.000 1.000 1500121000 15 Corn, field, meal 0.005000 1.000 1.000 1500121001 15 Corn, field, meal

- babyfood 0.005000 1.000 1.000 1500122000 15 Corn, field, bran 0.005000 1.000 1.000 1500123000 15 Corn, field, starch 0.005000 1.000 1.000 1500123001 15 Corn, field, starch

- babyfood 0.005000 1.000 1.000 1500124000 15 Corn, field, syrup 0.005000 1.000 1.000 DESAC decision 1500124001 15 Corn, field, syrup

- babyfood 0.005000 1.000 1.000 DESAC decision 1500125000 15 Corn, field, oil 0.005000 1.000 1.000 1500125 001 15 Corn, field, oil

- babyfood 0.005000 1.000 1.000 1500126000 15 Corn, pop 0.005000 1.000 1.000 1500127000 15 Corn, sweet 0.005000 1.000 1.000 1500127001 15 Corn , sweet

- babyfood 0.005000 1.000 1.000 1500231000 15 Oat, bran 0.050000 1.000 1.000 1500232000 15 Oat, flour 0.050000 1.000 1.000 1500232001 15 Oat, flour

- babyfo od 0.050000 1.000 1.000 1500233000 15 Oat, groats/rolled oats 0.050000 1.000 1.000 1500233001 15 Oat, groats/rolled oats

- babyfood 0.050000 1.000 1.000 1500328000 15 Rye, grain 0.050000 1.000 1.000 1500329000 15 Rye, flour 0.050000 1.000 1.000 1500381000 15 Triticale, flour 0.050000 1.000 1.000 1500381001 15 Triticale, flour

- babyfood 0.050000 1.000 1.000 1500401000 15 Wheat, grain 0.050000 1.000 0.025 max res / blended commodity 1500401001 15 Wheat, grain

- babyfood 0.050000 1.000 0.025 max res / blended commodity 1500402000 15 Wheat, flour 0.050000 1.000 0.025 max re s/ blended commodity 1500402001 15 Wheat, flour

- babyfood 0.050000 1.000 0.025 max re s/ blended commodity 1500403 000 15 Wheat, germ 0.050000 1.000 0.025 max re s/ blended commodity 1500404000 15 Wheat, bran 0.050000 1.000 0.025 max re s/ blended commodity 2100228000 21 Mushroom 4 0.000000 1.800 1.000 14 1.8x for benzimidazole 3100044000 31 Beef, meat 0.050000 1.000 1.000 FDA tol 3100044001 31 Beef, meat

- babyfood 0.050000 1.000 1.000 FDA tol 3100045000 31 Beef, meat, dried 0.050000 1.920 1.000 FDA tol 3100046000 31 Beef, meat byproducts 0.200000 1.000 1.000 max res 3100046001 31 Beef, meat byproducts

- babyfood 0.200000 1.000 1.000 max res 3100047000 31 Beef , fat 0.050000 1.000 1.000 FDA tol 3100047001 31 Beef, fat

- babyfood 0.050000 1.000 1.000 FDA tol 3100048000 31 Beef, kidney 0.200000 1.000 1.000 max res 3100049000 3 1 Beef, liver 0.070000 1.000 1.000 max res 3100049001 31 Beef, liver

- babyfood 0.070000 1.000 1.000 max res 3200169000 32 Goat, meat 0.001000 1.000 1.000 max res 3200170000 32 Goat, meat byproducts 0.200000 1.000 1.000 max res 3200171000 32 Goat, fat 0.005000 1.000 1.000 max res 3200172000 32 Goat, kidney 0.200000 1.000 1.000 max res 3200173000 32 Goat, liver 0.070000 1.000 1.000 max res 3300189000 33 Horse, meat 0.001000 1.000 1.000 max res 3400290000 34 Pork, meat 0.001000 1.000 1.000 max res 3400290001 34 Pork, meat

- babyfood 0.001000 1.000 1.000 max res 3400291000 34 Pork, skin 0.005000 1.000 1.000 max res 3400292000 34 Pork, meat byproducts 0.200000 1.000 1.000 max res 3400292001 34 Pork, meat byproducts

- babyfood 0.200000 1.000 1.000 max res 3400293000 34 Pork, fat 0.005000 1.000 1.000 max res 3400293001 34 Pork, fat

- babyfood 0. 005000 1.000 1.000 max res 3400294000 34 Pork, kidney 0.200000 1.000 1.000 max res

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 38 of 47 3400295000 34 Pork, liver 0.070000 1.000 1.000 max res 3500339000 35 Sheep, meat 0.001000 1.000 1.000 max res 3500339001 35 Sheep, meat

- babyfood 0.001000 1.000 1.000 max res 3500340000 35 Sheep, meat byproducts 0.200000 1.000 1.000 max res 3500341000 35 Sheep, fat 0.005000 1.000 1.000 max res 3500341001 35 Sheep, fat

- babyfood 0.005000 1.000 1.000 max res 3500342000 35 Sheep, kidney 0.200000 1.000 1.000 max res 3500343000 35 Sheep, liver 0.070000 1.000 1.000 max res 3600222000 36 Milk, fat 0.010000 1.000 1.000 PDP/max res 3600222001 36 Milk, fat

- baby food/infant formu 0.010000 1.000 1.000 PDP/max res 3600223000 36 Milk, nonfat solids 0.010000 1.000 1.000 PDP/max res 3600223001 36 Milk, nonfat solids

- baby food/in 0.010000 1.000 1.000 PDP/max res 3600224000 36 Milk, water 0.010000 1.000 1.000 PDP/m ax res 3600224001 36 Milk, water

- babyfood/infant form 0.010000 1.000 1.000 PDP/max res 3600225001 36 Milk, sugar (lactose)

- baby food/ 0.010000 1.000 1.000 PDP/max res 3800221000 38 Meat, game 0.001000 1.000 1.000 max res 3900312000 39 Rabbit, meat 0.001000 1.000 1.000 max res 8601000000 86A Water, direct, all sources 0.003800 1.000 1.000 8602000000 86B Water, indirect, all sources 0.003800 1.000 1.000 9500020000 O Avocado 0.001500 1.800 1.000 1.8x for benzimidazole 9500023000 O Banana 3.000000 1.000 1.000 3 9500023001 O Banana

- babyfood 3 .000000 1.000 1.000 3 9500024000 O Banana, dried 0.028000 3.900 1.000 9500024001 O Banana, dried

- babyfood 0.028000 3.900 1.000 9500215000 O Mango 10.000000 1.0 00 1.000 13 9500215001 O Mango

- babyfood 10.000000 1.000 1.000 13 9500216000 O Mango, dried 10.000000 1.000 1.000 13 9500217000 O Mango, juice 10.000000 1.000 1.000 13 9500217001 O Mango, juice

- babyfood 10.000000 1.000 1.000 13 9500245000 O Papaya 5.000000 1.000 1.000 15 9500245001 O Papaya

- babyfood 5.000000 1.000 1.000 15 9500246000 O Papaya, dried 0.080800 1.800 1.000 9500247000 O Papaya, juice 5.000000 1.500 1.000 15 9500283000 O Plantain 3.000000 1.000 1.000 3 9500284000 O Plantain, dried 0.028000 3.900 1.000

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 39 of 47 

## Attachment 4. **Acute Results file**

**- Food and Drinking Water** 

U.S. EPA Ver. 3.16, 03

- 08

- d
DEEM

- FCID ACUTE Analysis for THIABENDAZOLE NHANES 2003

- 2008 2

- Day Residue file: 060101ACUTEThiabendazole 3 7 14.R08 Adjustment factor #2 used. Analysis Date: 03

- 07

- 2014/12:42:53 Residue file dated: 03

- 07

- 2014/12:26:09 NOEL (Acute) = 50.000000 mg/kg body

- wt/day RAC/FF intake su mmed over 24 hours MC iterations = 1000; MC list in residue file; MC seed = 1024; RNG = MS VB Run Comment: ""

===============================================================================

Summary calculations

-- per capita:

--- 95th Percentile

---- -- - 99th Percentile

---- --- 99.9th Percentile

---- Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- Total US Population: 0.001294 2.59 38626 0.003914 7.83 12773 0.012953 25.91 3860 All Infants: 0.002214 4.43 22585 0.006619 13.24 7554 0.021098 42.20 2369 Children 1

- 2: 0.004926 9.85 10150 0.013111 26.22 3813 0 .034322 68.64 1456 Children 3

- 5: 0.003511 7.02 14241 0.010199 20.40 4902 0.028211 56.42 1772 Children 6

- 12: 0.001839 3.68 27187 0.006027 12.05 8296 0.017865 35.73 2798 Youth 13

- 19: 0.000866 1.73 57708 0.003082 6.16 16222 0.009042 18.08 5530 Adults 20

- 49: 0.000825 1.65 60631 0.002575 5.15 19418 0.007528 15.06 6641 Adults 50

- 99: 0.000896 1.79 55792 0.002775 5.55 18016 0.007786 15.57 6421 Female 13

- 49: 0.000805 1.61 62083 0.002638 5.28 18952 0.007789 15.58 6419

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 40 of 47 

## Attachment 5. Acute Results file

**- Food**  **O nly** 

U.S. EPA Ver. 3.16, 03

- 08

- d
DEEM

- FCID ACUTE Analysis for THIABENDAZOLE NHANES 2003

- 2008 2

- Day Residue file: 060101ACUTEThiabendazole FOOD ONLY 3 7 14.R08 Adjustment factor #2 used. Analysis Date: 03

- 07

- 2014/12:54:14 Residue file dated: 03

- 07

- 2014/12:27:50 NOEL (Acute) = 50. 000000 mg/kg body

- wt/day RAC/FF intake summed over 24 hours MC iterations = 1000; MC list in residue file; MC seed = 1024; RNG = MS VB Run Comment: ""

===============================================================================

Summary calculations

-- pe r capita:

--- 95th Percentile

---- --- 99th Percentile

---- --- 99.9th Percentile

---- Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- --- ----- Total US Population: 0.001186 2.37 42143 0.003811 7.62 13118 0.012887 25.77 3879 All Infants: 0.002001 4.00 24981 0.006324 12.65 7906 0.020320 40.64 2460 Children 1

- 2: 0.004785 9.57 10449 0. 013011 26.02 3842 0.034871 69.74 1433 Children 3

- 5: 0.003431 6.86 14572 0.010007 20.01 4996 0.027754 55.51 1801 Children 6

- 12: 0.001753 3.51 28528 0.005944 11.89 8411 0.017764 35.53 2814
Yout h 13

- 19: 0.000785 1.57 63656 0.002997 5.99 16680 0.008911 17.82 5611 Adults 20

- 49: 0.000706 1.41 70803 0.002457 4.91 20352 0.007495 14.99 6670 Adults 50

- 99: 0.000804 1.61 62190 0.002679 5.36 18663 0.007787 15.57 6421 Female 13

- 49: 0.000689 1.38 72590 0.002514 5.03 19888 0.007705 15.41 6489

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 41 of 47 

## Attachment **6 . CEC for Most Highly Exposed**  **Population Subgroup (Children 1** 

**- 2 years) file** 

U.S. EPA DEEM

- FCID Acute Critical Exposure Contribution Analysis (Ver. 3.16, 03

- 08

- d) NHANES 2003

- 2008 2

- Day Residue file = 060101ACUTEThiabendazole 3 7 14.R08 Acute report = acu te 3 7 14.AC8 Date and time of analysis: 03

- 07

- 2014 12:35:30 Daily totals for food and foodform consumption used. Adjustment factor #2 used. Minimum exposure contribution = 5% MC Iterations = 1000 Seed = 1024 RNG = MS VB Exposures divided by body weight

Subpopulation: Children 1

- 2 Low percentile for CEC records: 99 Exposure (mg/day) = 0.013111 High percentile for CEC records: 99.9 Exposure (mg/day) = 0.034322 Number of actual records in this interval: 2594

Critical foods with foodforms for this population (as derived from these records): N=number of appearances in all records (including duplicates) %=percent of total exposure for all records (including duplicates)

Food FF N Percent Food Name

---------- --- - ---- ------- ------------- 1100007000 110 1691 57.95% Apple, fruit with peel

- Uncooked; Fresh or N/S; Cook Meth N/S 1100266000 110 445 14.26% Pear

- Uncooked; Fresh or N/S; Cook Meth N/S 1100010000 110 355 9.03% Apple, juice

- Uncooked; Fresh or N/S; Cook Meth N/S 1100267000 132 86 3.41% Pear, dried

- Uncooked; Dried; Boiled 1100266000 240 81 1.86% Pear

- Cooked; Canned; Cook Meth N/S 1100010001 240 53 1.60% Apple, juice

- babyfood

- Cooke d; Canned; Cook Meth N/S 9500215000 110 44 1.35% Mango

- Uncooked; Fresh or N/S; Cook Meth N/S 1100011000 212 41 0.86% Apple, sauce

- Cooked; Fresh or N/S; Boiled 1100008001 240 24 0.66% Apple, peeled fruit

- babyfood

- Co oked; Canned; Cook Meth N/S 0103300000 212 22 0.52% Potato, tuber, w/o peel

- Cooked; Fresh or N/S; Boiled 1100010000 240 23 0.37% Apple, juice

- Cooked; Canned; Cook Meth N/S 9500217000 240 21 0.35% Mango, juice

- Cooked; Canned; Cook Meth N/S 3600224000 110 155 0.33% Milk, water

- Uncooked; Fresh or N/S; Cook Meth N/S 1100266000 210 22 0.32% Pear

- Cooked; Fresh or N/S; Cook Meth N/S 2100228000 210 13 0.18% Mushroom

- Cooked ; Fresh or N/S; Cook Meth N/S 0103300000 223 12 0.17% Potato, tuber, w/o peel

- Cooked; Frozen; Fried 1001240000 110 25 0.15% Orange

- Uncooked; Fresh or N/S; Cook Meth N/S 9500023000 110 36 0.11% Banana

- Uncooked; Fres h or N/S; Cook Meth N/S 9500023001 240 3 0.08% Banana

- babyfood

- Cooked; Canned; Cook Meth N/S 1100268001 240 4 0.07% Pear, juice

- babyfood

- Cooked; Canned; Cook Meth N/S 0103299000 211 3 0.07% Potato, tuber, w/peel

- Cooked; Fresh or N/S; Baked 

## TRUNCATED

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 42 of 47 

## Attachment **7**

**. Chronic Residue Input**  **F ile** 

Filename: 060101CHRONICThiabendazole 3 7 14.R08 Chemical: Thiabendazole RfD(Chronic): .033 mg/kg bw/day NOEL(Chronic): 10 mg/kg bw/day RfD(Acute): .05 mg/kg bw/day NOEL(A cute): 50 mg/kg bw/day Date created/last modified: 03

- 07

- 2014/12:30:50 Program ver. 3.16, 03

- 08

- d

----------------------------------------------------------------------------------- RDL indices and parameters for Monte Carlo Analysis: Index Dist Parameter #1 Param #2 Param #3 Comment # Code

----- ---- ------------ -------- -------- ------- 1 6 Apple Juice.rdf 2 6 Apples.rdf 3 6 Banana.rdf 4 6 Cantaloupe.rdf 5 6 Carrot.rdf 6 6 Frozen Potato.rdf 7 6 Potato.rdf 8 6 Orange Juice.rdf 9 6 Oranges.rdf 10 6 Pears Baby Food.rdf 11 6 Strawberry.rdf 12 6 Sweet Potato.rdf 13 6 Mango.rdf 14 6 Mushrooms.rdf 15 6 Papaya.rdf 16 6 Wheat fl our.rdf 17 6 Apple Sauce.rdf

Note: No residue distributions have been assigned to Commodities/FoodForms below

EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (p pm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101050000 1AB Beet, garden, roots 0.020000 1.000 1.000 0101050001 1AB Beet, garden, roots

- babyfood 0.020000 1.000 1.00 0 0101067000 1AB Burdock 0.020000 1.000 1.000 0101078000 1AB Carrot 0.014900 1.000 1.000 0101078001 1AB Carrot

- babyfood 0.002000 1.000 1.000 0101079000 1AB Carrot, juice 0.014900 1.000 1.000 0101084000 1AB Celeriac 0.020000 1.000 1.000 0101100000 1AB Chicory, roots 0.020000 1.000 1.000 0101168000 1AB Ginseng, dried 0.020000 1.000 1.000 0101190000 1AB Horseradish 0.020000 1.000 1.000 0101250000 1AB Parsley, turnip rooted 0.020000 1.000 1.000 0101251000 1AB Parsnip 0.020000 1.000 1.000 0101251001 1AB Parsnip

- babyfood 0.020000 1.000 1.000 0101314000 1AB Radish, roots 0.020000 1.000 1.000 0101316000 1AB Radish, Oriental, roots 0.020000 1.000 1.000 0101327000 1AB Rutabaga 0.020000 1.000 1.000 0101331000 1AB Salsify, roots 0.020000 1.000 1.000 0101388000 1AB Turnip, roots 0.020000 1.000 1.000 0103296000 1C Potato, chips 0.028900 1.000 1.000 Residues Do Not Concentrate 0103297000 1C Potato, dry (granules/ flakes) 0.028900 1.000 1.000 Residues Do Not Concentrate 0103297001 1C Potato, dry (granules/ flakes)

- b 0.028900 1.000 1. 000 Residues Do Not Concentrate 0103298000 1C Potato, flour 0.028900 1.000 1.000 Residu e s Do Not Concentrate 0103298001 1C Potato, flour

- babyfood 0.028900 1.000 1.000 Residu e s Do Not Concentrate 0103299000 1C Potato, tuber, w/peel 0.028900 1.000 1.000 0103299001 1C Potato, tuber, w/peel

- babyfood 0.028900 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.028900 1.000 1.000 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.028900 1.000 1.000 0103366000 1CD Sweet potato 0.005000 1.400 1.000 1.4x for benzimidazole 0103366001 1CD Sweet potato

- babyfood 0.001500 1.400 1.000 1.4x for benzimidazole 0103406000 1CD Yam, true 0.005000 1.400 1.000 1.4x for benzimidazole 0301165000 3A Garlic, bulb 0.020000 1.000 1.000 0301165001 3A Garlic, bulb

- babyfood 0.020000 1.000 1.000 0301237000 3A Onion, bulb 0.020000 1.000 1.000 0301237001 3A Onion, bulb

- babyfood 0.020000 1.000 1.000 0301238000 3A Onion, bulb, dried 0.020000 1.000 1.000 0301238001 3A Onion, bu lb, dried

- babyfood 0.020000 1.000 1.000 0301338000 3A Shallot, bulb 0.020000 1.000 1.000 0401355000 4A Spinach 0.020000 1.000 1.000

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 43 of 47 0401355001 4A Spinach

- babyfood 0.020000 1.000 1.000 0501061000 5A Broccoli 0.020000 1.000 1.000 0501061001 5A Broccoli

- babyfood 0.020000 1.000 1.000 0501062000 5A Broccoli, Chinese 0.020000 1.000 1.000 0501064000 5A Brussels sprouts 0.020000 1.000 1.000 0501069000 5A Cabbage 0.020000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 0.020000 1.000 1.000 0501072000 5A Cabbage , Chinese, mustard 0.020000 1.000 1.000 0501083000 5A Cauliflower 0.020000 1.000 1.000 0501196000 5A Kohlrabi 0.020000 1.000 1.000 0600347000 6 Soybean, seed 0.100000 1.000 0.010 Tol and blended commodity 0600349000 6 Soybean, soy milk 0.100000 1.000 0.010 Tol and blended commodity 0600349001 6 Soybean, soy milk

- babyfood or in 0.100000 1.000 0.010 Tol and blended commodit y 0600350000 6 Soybean, oil 0.100000 1.000 0.010 Tol and blended commodity 0600350001 6 Soybean, oil

- babyfood 0.100000 1.000 0.010 Tol and blended commodity 0603030000 6C Bean, black, seed 0.100000 1.000 1.000 0603032000 6C Bean, broad, seed 0.100000 1.000 1.000 0603034000 6C Bean, cowpea, seed 0.100000 1.000 1.000 0603035000 6C Bean, great northern, seed 0.100000 1.000 1.000 0603036000 6C Bean, kidney, seed 0.100000 1.000 1.000 0603038000 6C Bean, lima, seed 0.100000 1.000 1.000 0603039000 6C Bean, mung, seed 0.100000 1.000 1.000 0603040000 6C Bean, navy, seed 0.100000 1.000 1.000 0603041000 6C Bean, pink, seed 0.100000 1.000 1.000 0603042000 6C Bean, pinto, seed 0.100000 1.000 1.000 0603098000 6C Chickpea, seed 0.100000 1.000 1.000 0603098001 6C Chickpea, seed

- babyfood 0.100000 1.000 1.000 0603099000 6C Chickpea, flour 0.100000 1.000 1.000 0603182000 6C Guar, seed 0.100000 1.000 1.000 0603182001 6C Guar, seed

- babyfood 0.100000 1.000 1.000 0603203000 6C Lentil, seed 0.005000 1.000 1.000 0603256000 6C Pea, dry 0.005000 1.000 1.000 0603256001 6C Pea, dry

- babyfood 0.005000 1.000 1.000 0603258000 6C Pea, pigeon, seed 0.005000 1.000 1.000 0603348000 6C Soybean, flour 0.100000 1.000 1.000 0603348001 6C Soybean , flour

- babyfood 0.100000 1.000 1.000 0901075000 9A Cantaloupe 0.005200 1.800 1.000 1.8x for benzimidazole 0901187000 9A Honeydew melon 0.020000 1.000 1.000 0901399000 9A Watermelon 0.020000 1.000 1.000 0901400000 9A Watermelon, juice 0.020000 1.000 1.000 0902021000 9B Balsam pear 0.020000 1.000 1.000 0902088000 9B Chayote, fruit 0.020000 1.000 1.000 0902102000 9B Chinese waxgourd 0.020000 1.000 1.000 0902135000 9B Cucumber 0.020000 1.000 1.000 0902308000 9B Pumpkin 0.020000 1.000 1.000 0902309000 9B Pumpkin, seed 0.020000 1.000 1.000 0902356000 9B Squash, summer 0.020000 1.000 1.000 0902356001 9B Squash, summer

- babyfood 0.020000 1.000 1.000 0902357000 9B Squash, winter 0.020000 1.000 1.000 0902357001 9B Squash, winter

- babyfood 0.020000 1.000 1.000 1001106000 10A Citron 0.030500 1.000 1.000 1001107000 10A Citrus hybrids 0.030500 1.000 1.000 1001108000 10A Citrus, oil 15.000000 1.000 1.000 1001240000 10A Orange 0.030500 1.000 1.000 1001241000 10A Orange, j uice 0.015100 1.000 1.000 1001241001 10A Orange, juice

- babyfood 0.015100 1.000 1.000 1001242000 10A Orange, peel 10.000000 3.300 1.000 Conc. for peel 1001369000 10A Tangerine 0.030500 1.000 1.000 1001370000 10A Tangerine, juice 0.015100 1.000 1.000 1002197000 10B Kumquat 0.030500 1.000 1.000 1002199000 10B Lemon 0.030500 1.000 1.000 1002200000 10B Lemon, juice 0.015100 1.000 1.000 1002200001 10B Lemon, juice

- babyfood 0.015100 1.000 1.000 1002201000 10B Lemon, peel 10.000000 3.300 1.000 Conc. for peel 1002206000 10B Lime 0.030500 1.000 1.000 1002207000 10B Lime, juice 0.015100 1.000 1.000 1002207001 10B Lime, juice

- babyfood 0.015100 1.000 1.000 1003180000 10C Grap efruit 0.030500 1.000 1.000 1003181000 10C Grapefruit, juice 0.015100 1.000 1.000 1003307000 10C Pummelo 0.030500 1.000 1.000 1100007000 11 Apple, fruit with peel 0.274100 1.000 1.000 1100008000 11 Apple, peeled fruit 0.274100 1.000 1.000 1100008001 11 Apple, peeled fruit

- babyfood 0.274100 1.000 1.000 1100009000 11 Apple, dried 0.274100 8.000 1 .000 1100009001 11 Apple, dried

- babyfood 0.274100 8.000 1.000

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 44 of 47 1100010000 11 Apple, juice 0.019100 1.000 1.000 1100010001 11 Apple, juice

- babyfood 0.019100 1.000 1.000 1100011000 11 Ap ple, sauce 0.045800 1.000 1.000 1100011001 11 Apple, sauce

- babyfood 0.001500 1.000 1.000 1100129000 11 Crabapple 0.274100 1.000 1.000 1100173500 11 Goji berry 0.274100 1.000 1.000 1100210000 11 Loquat 0.274100 1.000 1.000 1100266000 11 Pear 0.274100 1.000 1.000 1100266001 11 Pear

- baby food 0.006200 1.000 1.000 1100267000 11 Pear, dried 0.274100 6.250 1.000 1100268000 11 Pear, juice 0.019100 1.000 1.000 1100268001 11 Pear, juice

- babyfood 0.019100 1.000 1.000 1100310000 11 Quince 0.274100 1.000 1.000 1307359000 13G Strawberry 0.015100 1.800 1.000 1.8x for benzimidazole 1307359001 13G Strawberry

- babyfood 0. 015100 1.800 1.000 1.8x for benzimidazole 1307360000 13G Strawberry, juice 0.015100 1.800 1.000 1.8x for benzimidazole 1307360001 13G Strawberry, juice

- babyfood 0.015100 1.800 1.000 1.8x for benzimidazole 1500025000 1 5 Barley, pearled barley 0.050000 1.000 1.000 1500025001 15 Barley, pearled barley

- babyfood 0.050000 1.000 1.000 1500026000 15 Barley, flour 0.050000 1.000 1.000 1500026001 15 Barley, flour

- babyfoo d 0.050000 1.000 1.000 1500027000 15 Barley, bran 0.050000 1.000 1.000 1500120000 15 Corn, field, flour 0.005000 1.000 1.000 1500120001 15 Corn, field, flour

- babyfood 0.005000 1.000 1.000 1500121000 15 Corn, field, meal 0.005000 1.000 1.000 1500121001 15 Corn, field, meal

- babyfood 0.005000 1.000 1.000 1500122000 15 Corn, field, bran 0.005000 1.000 1.000 1500123000 15 Corn, field, starch 0.005000 1.000 1.000 1500123001 15 Corn, field, starch

- babyfood 0.005000 1.000 1.000 1500124000 15 Corn, field, syrup 0.005000 1.000 1.000 DESAC decision 1500124001 15 Corn, field, syrup

- babyfood 0.005000 1.000 1.000 DESAC decision 1500125000 15 Corn, field, oil 0.005000 1.000 1.000 1500125001 15 Corn, field, oil

- babyfood 0.005000 1.000 1.000 1500126000 15 Corn, pop 0.005000 1.000 1.000 1500127000 15 Corn, sweet 0.005000 1.000 1.000 1500127001 15 Corn, sweet

- babyfood 0.005000 1.000 1.000 1500231000 15 Oat, bran 0.050000 1.000 1.000 1500232000 15 Oat, flour 0.050000 1.000 1.000 1500232001 15 Oat, flour

- babyfood 0.050000 1.000 1.000 1500233000 15 Oat, groa ts/rolled oats 0.050000 1.000 1.000 1500233001 15 Oat, groats/rolled oats

- babyfood 0.050000 1.000 1.000 1500328000 15 Rye, grain 0.050000 1.000 1.000 1500329000 15 Rye, flour 0.050000 1.000 1.000 1500381000 15 Triticale, flour 0.050000 1.000 1.000 1500381001 15 Triticale, flour

- babyfood 0.050000 1.000 1.000 1500401000 15 Wheat, grain 0.050000 1.000 0.010 max res and blended commodity 1500401001 15 Wheat, grain

- babyfood 0.050000 1.000 0.010 max res and blended commodity 1500402000 15 Wheat, flour 0.050000 1.000 0.010 max res and blended commodity 1500402001 15 Wheat, flour

- babyfood 0.050000 1.000 0.010 max res and blended commodity 1500403000 15 Wheat, germ 0.050000 1.000 0.010 max res and blended commodity 1500404000 15 Wheat, bran 0.0500 00 1.000 0.010 max res and blended commodity 2100228000 21 Mushroom 0.183600 1.800 1.000 1.8x for benzimidazole 3100044000 31 Beef, meat 0.050000 1.000 1.000 FDA tol 3100044001 31 Beef, me at

- babyfood 0.050000 1.000 1.000 FDA tol 3100045000 31 Beef, meat, dried 0.050000 1.920 1.000 FDA tol 3100046000 31 Beef, meat byproducts 0.200000 1.000 1.000 max res 3100046001 31 Beef, meat b yproducts

- babyfood 0.200000 1.000 1.000 max res 3100047000 31 Beef, fat 0.050000 1.000 1.000 FDA tol 3100047001 31 Beef, fat

- babyfood 0.050000 1.000 1.000 FDA tol 3100048000 31 Beef, kidney 0.200000 1.000 1.000 max res 3100049000 31 Beef, liver 0.070000 1.000 1.000 max res 3100049001 31 Beef, liver

- babyfood 0.070000 1.000 1.000 max res 3200169000 32 Goat, meat 0.001000 1.000 1.000 max res 3200170000 32 Goat, meat byproducts 0.200000 1.000 1.000 max res 3200171000 32 Goat, fat 0.005000 1.000 1.000 max res 3200172000 32 Goat, kidney 0.200000 1.000 1.000 max res 3200173000 32 Goat, liver 0.070000 1.000 1.000 max res 3300189000 33 Horse, meat 0.001000 1.000 1.000 max res 3400290000 34 Pork, meat 0.001000 1.000 1.000 max res 3400290001 34 Pork, meat

- babyfood 0.001000 1.000 1.000 max res 3400291000 34 Pork, skin 0.005000 1.000 1.000 max res 3400292000 34 Pork, meat byproducts 0.200000 1.000 1.000 max res 3400292001 34 Pork, meat byproducts

- babyfood 0.200000 1.000 1.000 max res 3400293000 34 Pork, fat 0.005000 1.000 1.000 max res 3400293001 34 Pork, fat

- babyfood 0 .005000 1.000 1.000 max res

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 45 of 47 3400294000 34 Pork, kidney 0.200000 1.000 1.000 max res 3400295000 34 Pork, liver 0.070000 1.000 1.000 max res 3500339000 35 Sheep, meat 0.001 000 1.000 1.000 max res 3500339001 35 Sheep, meat

- babyfood 0.001000 1.000 1.000 max res 3500340000 35 Sheep, meat byproducts 0.200000 1.000 1.000 max res 3500341000 35 Sheep, fat 0.005000 1.000 1.000 max res 3500341001 35 Sheep, fat

- babyfood 0.005000 1.000 1.000 max res 3500342000 35 Sheep, kidney 0.200000 1.000 1.000 max res 3500343000 35 Sheep, liver 0.070000 1. 000 1.000 max res 3600222000 36 Milk, fat 0.010000 1.000 1.000 PDP/max res 3600222001 36 Milk, fat

- baby food/infant formu 0.010000 1.000 1.000 PDP/max res 3600223000 36 Milk, nonfat solids 0.010000 1.000 1.000 PDP/max res 3600223001 36 Milk, nonfat solids

- baby food/in 0.010000 1.000 1.000 PDP/max res 3600224000 36 Milk, water 0.010000 1.000 1.000 PDP/max res 3600224001 36 Milk, water

- babyfood/infant form 0 .010000 1.000 1.000 PDP/max res 3600225001 36 Milk, sugar (lactose)

- baby food/ 0.010000 1.000 1.000 PDP/max res 3800221000 38 Meat, game 0.001000 1.000 1.000 max res 3900312000 39 Rabbit, meat 0.001000 1.000 1.000 max res 8601000000 86A Water, direct, all sources 0.000470 1.000 1.000 8602000000 86B Water, indirect, all sources 0.000470 1.000 1.000 9500020000 O Avocado 0.001500 1.80 0 1.000 1.8x for benzimidazole 9500023000 O Banana 0.028000 1.000 1.000 9500023001 O Banana

- babyfood 0.028000 1.000 1.000 9500024000 O Banana, dried 0.028000 3.900 1.000 9500024001 O Banana, dried

- babyfood 0.028000 3.900 1.000 9500215000 O Mango 0.077900 1.000 1.000 9500215001 O Mango

- babyfood 0.077900 1.000 1.000 9500216000 O M ango, dried 0.077900 1.000 1.000 9500217000 O Mango, juice 0.077900 1.000 1.000 9500217001 O Mango, juice

- babyfood 0.077900 1.000 1.000 9500245000 O Papaya 0.080800 1.000 1.000 9500245001 O Papaya

- babyfood 0.080800 1.000 1.000 9500246000 O Papaya, dried 0.080800 1.800 1.000 9500247000 O Papaya, juice 0.080800 1.500 1.000 9500283000 O Plantain 0.028000 1.000 1.000 9500284000 O Plantain, dried 0.028000 3.900 1.000

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 46 of 47 

## Attachment **8**

**. Chronic Results File** 

U.S. EPA Ver. 3.16, 03

- 08

- d
DEEM

- FCID Chronic analysis for THIABENDAZOLE NHANES 2003

- 2008 2

- day Residue file name: 060101CHRONICThiabendazole 3 7 14.R08 Adjustment fac tor #2 used. Analysis Date 03

- 07

- 2014/12:55:32 Residue file dated: 03

- 07

- 2014/12:30:50 Reference dose (RfD, Chronic) = .033 mg/kg bw/day

=============================================================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.000379 1.1% Hispanic 0.000499 1.5%
Non

- Hisp

- White 0.000359 1.1%
Non

- Hisp

- Black 0.000321 1.0%
Non

- Hisp

- Other 0.000468 1.4% Nursing Infants 0.000371 1.1%
Non

- Nursing Infants 0.000720 2.2% Female 13+ PREG 0.000329 1.0% Children 1

- 6 0.001223 3.7% Children 7

- 12 0.000542 1.6% Male 13

- 19 0.000315 1.0% Female 13

- 19/NP 0.000276 0.8% Male 20+ 0.000281 0.9% Female 20+/NP 0.000259 0.8% Seniors 55+ 0.000277 0.8% All Infants 0.000612 1.9% Female 13

- 50 0.000256 0.8% Children 1

- 2 0.001562 4.7% Children 3

- 5 0.001081 3.3% Children 6

- 12 0.000597 1.8% Youth 13

- 19 0.000295 0.9% Adults 20

- 49 0.000267 0.8% Adults 50

- 99 0.000276 0.8% Female 13

- 49 0.000256 0.8%

----------------------------------------------- --------------------------------

### Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 47 of 47 

## Attachment **9**

**. Screening Level Usage Analysis (SLUA) for Thiabendazole (060101)** 

**SLUA for Thiabendazole February 22, 2013**  **(Reporting Timeframe: 2004**

**- 2011)** 

**Percent Crop Treated Crop**  **Lbs. A.I. Average**  **Maximum 1**  **Potatoes**

**– seed treatment**  **<500 <1**  **<2.5 2**  **Soybeans**

**– seed treatment**  **<500 <1**  **<2.5 3**  **Wheat**

**– seed treatment**  **<500 <1**  **<2.5** All numbers rounded. <500 Less than 500 Lbs of active ingredient <2.5 Less than 2.5 percent of crop treated <1 Less than 1 percent of crop treated

SLUA data sources include: USDA

-NASS (United States Department of Agriculture's National Agricultural Statistics Service) Private Pesticide Market Research

These results reflect amalgamated data developed by the Agency and are releasable to the public.