Exhibit 10.1


 


THIRD AMENDMENT TO EMPLOYMENT
AGREEMENT


 


This Third Amendment to Employment Agreement
(“Third Amendment”), effective as of April 14, 2016 (the “Effective Date”) is entered into by and between
ArQule, Inc., a Delaware corporation (the “Company”) with its principal offices at One Wall Street, Burlington, Massachusetts
01803, and Paolo Pucci (“Executive”). The purpose of this Third Amendment is to amend the employment agreement dated
as of April 15, 2008 between the Company and Executive, as previously amended by an agreement effective as of July 15, 2010 (the
“First Amendment”), and as further amended by an agreement effective as of March 8, 2013 (the “Second Amendment”);
the employment agreement as so amended is hereinafter referred to as the “Employment Agreement”). Capitalized terms
used but not defined in this Third Amendment shall have the meanings ascribed to them in the Employment Agreement.


 


In consideration of the mutual covenants
and agreements contained herein and for other good and valuable consideration, the receipt, adequacy and sufficiency of which are
hereby acknowledged, the Company and Executive (collectively, the “Parties”) hereby agree as follows:


 


		1	Term of Employment. Section 1 of the Employment Agreement, as amended, is hereby amended and replaced in its entirety
with the following:



 


“The Company hereby agrees to continue to employ
Executive, and Executive hereby accepts such continued employment with the Company, upon the terms and subject to the conditions
set forth in the Employment Agreement. The Parties agree that the employment term shall continue through December 31, 2018, unless
earlier terminated in accordance with the provisions of Section 5 of the Employment Agreement (the “Employment Term”),
provided that the Company shall provide Executive with no fewer than ninety (90) days advance written notice in the event it decides
not to extend this Agreement beyond the Employment Term or negotiate in good faith a new agreement, and in the event the Company
does not provide such 90-day advance notice, the Company shall pay Executive up to 90 days of his Base Salary in lieu of such advance
notice.”


 


		2	Entire Understanding. This Third Amendment constitutes the entire understanding and agreement between the Parties regarding
the subject matter hereof and supersedes all prior agreements, written or oral, with respect to the subject matter hereof, except
that, other than as explicitly modified by the terms of this Third Amendment, the Employment Agreement shall remain in full force
and effect in accordance with its provisions. This Third Amendment shall be incorporated into the Employment Agreement as an additional
provision thereto.



 


		3	Governing Law. This Third Amendment shall be governed by and construed and enforced in accordance with the law (other
than the law governing conflict of law questions) of the Commonwealth of Massachusetts.



 


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IN WITNESS WHEREOF,
the Parties have executed or caused to be executed this Amendment as of the date set forth above.


 


	ARQULE, INC.	 	EXECUTIVE
	 	 	 	 	 
	By:	/s/ William G. Messenger	 	By:	/s/ Paolo Pucci
	Name: William G. Messenger	 	Name:  Paolo Pucci
	Title: Chairman of the Compensation,	 	 	 
	Nominating and Governance Committee