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Summary Minutes of the

U.S. Environmental Protection Agency (EPA)

Clean Air Scientific Advisory Committee (CASAC)

Lead Review Panel

Public Teleconference

May 30, 2012

Date and Time: Wednesday, May 30, 2012, 12:00 PM – 3:00 PM ET

Location: Teleconference Only

Purpose: The purpose of the meeting was to discuss the CASAC Lead Review Panel’s 

05-16-12 Draft Review of the EPA’s Integrated Science Assessment (ISA) for 

Lead (Second External Review Draft – February 2012)

Participants: Lead Review Panel (for full roster, see Attachment A)

Dr. H. Christopher Frey, Chair

Mr. George Allen

Dr. Herbert Allen

Dr. Richard Canfield

Dr. Cliff Davidson

Dr. Sean Hays

Dr. Susan Korrick

Dr. Michael Kosnett

Dr. Roman Lanno

Mr. Richard Poirot

Dr. Joel Pounds

Dr. Michael Rabinowitz

Dr. William Stubblefield

Dr. Ian von Lindern

Dr. Gail Wasserman

Mr. Aaron Yeow, Designated Federal Officer (DFO)

Wednesday, May 30, 2012

Opening Remarks

Mr. Aaron Yeow, the DFO for the CASAC Lead Review Panel took roll and opened the 

meeting. He noted that as required under the Federal Advisory Committee Act (FACA), the 

Panel’s deliberations are held in public with advanced notice given in the Federal Register1, and 

the meeting minutes will be made publicly available after the meeting. He noted that there was 

one registered public speaker and a copy of the oral statement was available on the meeting 

webpage. He also noted that the SAB Staff Office determined that there were no issues with 
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conflict-of-interest or appearance of a lack of impartiality for any of the advisory panel members 

participating in the review. He then turned the meeting over to Dr. Chris Frey, Chair of the 

CASAC Lead Review Panel.

Dr. Frey welcomed everyone, stated the purpose of the teleconference was to review the Panel’s 

draft review of EPA’s 2nd Draft Lead ISA, and reviewed the Agenda2.

Public Comments

Stephanie Shirley, Texas Commission on Environmental Quality, presented her oral statement3

and stated that the draft ISA frequently confuses associations with causations. She stated that the 

discussion of lead exposure and IQ did not adequately address uncertainties and confounders. 

Lastly she stated that inhalation of Pb is a minor exposure pathway compared to other exposure 

pathways. One panel member asked her which confounders in the Pb-IQ literature she found 

were not addressed. She indicated it was mainly paternal IQ, which another panel member stated 

was addressed in some of her studies.

Discussion of Consensus Responses

The Panel proceeded through the Consensus Responses. There was some discussion on how to 

clarify the statement in the response to the Chapter 1 charge question on the reversibility of 

health effects. For the response to Chapter 3 charge questions, there was some discussion on Pb 

wheel weights and it was agreed to add a sentence stating that EPA should review a particular 

recent study on Pb wheel weights. For the response to the Chapter 5 charge questions, there was 

some discussion on refining the comment regarding the need for utilizing experts in 

psychometric assessment as well as clarifying the comment on short duration exposures. For the 

response to the Chapter 6 charge questions, there was discussion of adding a bullet regarding the 

potential susceptibility of African Americans to lead possibly arising from factors not mediated 

by SES or exposure. There was also discussion about adding a statement that the discussion of 

the effect of fluoridation on lead exposure in the Integrative Summary was not supported by the 

literature and should be removed.

Discussion of Letter to Administrator

The Panel proceeded through the Letter to the Administrator with recommendations to improve 

the clarity and had some discussion on the need for an overarching comment that states that the 

ISA presents the discussion of many studies in an encyclopedic fashion, lacking an integrative 

synthesis.

The Panel and the members of CASAC were satisfied with the letter/report with the changes 

discussed and did not have any further comments.

With business concluded, the meeting was adjourned by the DFO at 2:15 pm.
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Respectfully Submitted: Certified as Accurate:

/SIGNED/ /SIGNED/

Mr. Aaron Yeow Dr. H. Christopher Frey

Designated Federal Officer Chair

EPA SAB Staff Office CASAC Lead Review Panel

NOTE AND DISCLAIMER: The minutes of this public meeting reflect diverse ideas and 

suggestions offered by Panel members during the course of deliberations within the meeting. Such 

ideas, suggestions and deliberations do not necessarily reflect consensus advice from the Panel 

members. The reader is cautioned to not rely on the minutes to represent final, approved, consensus 

advice and recommendations offered to the Agency. Such advice and recommendations may be 

found in the final advisories, commentaries, letters or reports prepared and transmitted to the EPA 

Administrator following the public meetings.
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Materials Cited

The following meeting materials are available on the CASAC website: 

http://www.epa.gov/casac, at the May 30, 2012 CASAC Lead Review Panel Meeting page:

 

1

Federal Register Notice Announcing the Meeting

2 Agenda for May 30, 2012 Public Meeting

3 Oral Statement from Stephanie Shirley, Texas Commission on Environmental Quality
A-1

ATTACHMENT A - ROSTER

U.S. Environmental Protection Agency

Clean Air Scientific Advisory Committee

CASAC Lead Review Panel

CHAIR

Dr. H. Christopher Frey, Professor, Department of Civil, Construction and Environmental 

Engineering, College of Engineering, North Carolina State University, Raleigh, NC

CASAC MEMBER

Mr. George A. Allen, Senior Scientist, Northeast States for Coordinated Air Use Management 

(NESCAUM), Boston, MA

CONSULTANTS

Dr. Herbert Allen, Professor Emeritus, Department of Civil and Environmental Engineering, 

University of Delaware, Newark, DE

Dr. Richard Canfield, Senior Research Associate, Division of Nutritional Sciences, Cornell 

University, Ithaca, NY

Dr. Deborah Cory-Slechta, Professor, Department of Environmental Medicine, School of 

Medicine and Dentistry, University of Rochester, Rochester, NY

Dr. Cliff Davidson, Professor, Civil and Environmental Engineering, Syracuse University, 

Syracuse, NY

Dr. Philip E. Goodrum, Senior Consultant, Cardno ENTRIX, Syracuse, NY

Dr. Sean Hays, President, Summit Toxicology, Allenspark, CO

Dr. Philip Hopke, Bayard D. Clarkson Distinguished Professor, Department of Chemical and 

Biomolecular Engineering, Clarkson University, Potsdam, NY

Dr. Chris Johnson, Professor, Department of Civil and Environmental Engineering, Syracuse 

University, Syracuse, NY

Dr. Susan Korrick, Assistant Professor of Medicine , Department of Medicine, Brigham and 

Women's Hospital, Channing Laboratory, Harvard Medical School, Boston, MA
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Dr. Michael Kosnett, Associate Clinical Professor, Division of Clinical Pharmacology and 

Toxicology, Department of Medicine, University of Colorado School of Medicine, Denver, CO

Dr. Roman Lanno, Associate Professor and Associate Chair, Department of Evolution, 

Ecology, and Organismal Biology, Ohio State University, Columbus, OH

Mr. Richard L. Poirot, Environmental Analyst, Air Pollution Control Division, Department of 

Environmental Conservation, Vermont Agency of Natural Resources, Waterbury, VT

Dr. Joel G. Pounds, Laboratory Fellow, Cell Biology & Biochemistry, Biological Sciences 

Division, Pacific Northwest National Laboratory, Richland, WA

Dr. Michael Rabinowitz, Geochemist, Marine Biological Laboratory, Newport, RI

Dr. William Stubblefield, Senior Research Professor, Department of Molecular and 

Environmental Toxicology, Oregon State University, Corvallis, OR

Dr. Ian von Lindern, President, TerraGraphics Environmental Engineering, Inc., Moscow, ID

Dr. Gail Wasserman, Professor of Clinical Psychology in Child Psychiatry, Division of Child 

and Adolescent Psychiatry, College of Physicians and Surgeons, Columbia University, New 

York, NY

Dr. Michael Weitzman, Professor, Pediatrics; Psychiatry, New York University School of 

Medicine, New York, NY

SCIENCE ADVISORY BOARD STAFF

Mr. Aaron Yeow, Designated Federal Officer, U.S. Environmental Protection Agency, Science 

Advisory Board,Washington, DC
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ATTACHMENT B – Other Attendees

CASAC Lead Review Panel Public Teleconference

(Persons who requested the teleconference call-in number or indicated they were on the call)

May 30, 2012

Name Affliation

Brown, James EPA

Deitrich, Casey FDCH

Dubois, Jean Jacques EPA

Hopkinson, Jenny InsideEPA

Hoyer, Marion EPA

Jacobs, Jeremy Greenwire

Kirrane, Ellen EPA

Kotchmar, Dennis EPA

Lassiter, Meredith EPA

Murphy, Deirdre EPA

Nystrom, Marci California Air Resources Board

Orlin, David EPA

Owens, Elizabeth EPA

Patel, Molini EPA

Richmond-Bryant, Jennifer EPA

Ross, Mary EPA

Shirley, Stephanie Texas Commission on Environmental Quality

Stanek, Lindsay EPA

Tennant, Ginger EPA

Vinikoor-Imler, Lisa EPA

Walsh, Debra EPA

Wilson, Linda NYS Office of the Attorney General