EX-10.41



 Exhibit 10.41 

FOURTH AMENDMENT TO BUILD TO SUIT LEASE 

This FOURTH AMENDMENT TO BUILD TO SUIT LEASE (this “Amendment”) is made as of March 1, 2016, by and between Britannia Pointe Grand
Limited Partnership, a Delaware limited partnership or its assigns (“Landlord”) and Cytokinetics, Inc., a Delaware corporation (“Tenant”), under the following circumstances: 

Landlord and Tenant, as successor in interest to MetaXen, LLC the original tenant under the Lease (as defined below) and to Exelixis, Inc. as
successor in interest to MetaXen, LLC., are parties to that certain Build to Suit Lease dated as of May 27, 1997, as amended by First Amendment to Lease dated as of April 13, 1998, as further amended by Second Amendment to Lease dated as
of July 11, 1999, and as further amended by Third Amendment to Lease dated as of December 10, 2010 (collectively, the “Lease”) whereby Landlord leases to Tenant approximately 81,587 rentable square feet, consisting of the
entire building (50,195 rentable square feet) located at 280 East Grand Avenue, South San Francisco, California (the “280 Building”) and 31,392 rentable square feet in the building located at 256 East Grand Avenue, South San
Francisco, California (the “256 Building”) (collectively, the “Premises”); and 
 Landlord and Tenant are
executing this Amendment in order to modify certain terms of the Lease. NOW THEREFORE, in consideration of the promises and the agreements and covenants contained herein, Landlord and Tenant agree that the Lease is amended and modified as follows:

  

	A.	Amendments 

 1. Landlord, through its project manager, Project Management Advisors, Inc.
(“PMA”), shall either replace or retrofit (to be determined in Landlord’s sole and absolute discretion) two (2) boilers located in the 280 Building (the “Boiler Project”). All costs associated with the
Boiler Project, including any fees charged by PMA for its services therein, shall be amortized by Landlord over a fifteen (15) year period and included as part of Operating Expenses for the Premises. An estimated budget and amortization
schedule (the “Estimated Costs”) is attached hereto as Exhibit A. Landlord and Tenant acknowledge that the actual costs of the Boiler Project may differ from that reflected in the Estimated Costs and that the amortization
schedule will be adjusted to reflect actual documented costs; provided, however, that Landlord will not approve any change orders increasing the estimated budget by more than five percent (5%) without obtaining Tenant’s prior written
approval. 
 2. In the event Tenant (a) does not renew the Lease at expiration, (b) relocates to a property not owned by Landlord
or one of its affiliates upon the expiration of this Lease, or (c) this Lease is terminated for any other reason prior to expiration, then Tenant shall be obligated to pay all unamortized costs associated with the Boiler Project to Landlord at
expiration or earlier termination of this Lease. 
  

	B.	Miscellaneous 

 1. Except as amended by this Amendment, the Lease is not otherwise
amended, and the Lease remains in full force and effect, as amended hereby. In the event of a conflict between the terms of this Amendment and the terms of the Lease, the terms of this Amendment shall control. Capitalized terms used in this
Amendment but not defined herein shall have the meaning set forth in the Lease. 
 [signatures on following page] 







 IN WITNESS WHEREOF, Landlord and Tenant have executed this Amendment as of the date first above written.

  

			
	LANDLORD:
	
	BRITANNIA POINTE GRAND LIMITED PARTNERSHIP, a Delaware limited partnership
	
	By HCP-Pointe Grand, Incorporated, its general partner
		
	By:	 	/s/ Jonathan M. Bergschneider
		
	Name:	 	Jonathan M. Bergschneider
	Title:	 	Executive Vice President


  

			
	TENANT:
	
	CYTOKINETICS, INC., a Delaware corporation
		
	By:	 	/s/ Sharon A. Barbari
		
	Name:	 	Sharon A. Barbari
	Title:	 	EVP, Finance & CFO









 Exhibit A 

Estimated Costs 
 Cytokinetics Boiler
replacement Project 
 cost amortization Estimated - 2/22/16 
  

			
	Estimated Project Cost	  	202, 156.00
	Interest Rate	  	7.00%
	Amortization period	  	15.0 years
	Amort. Start date	  	6/1/16

  

																					
	 	  	Month	 	  	Payment	 	  	Interest	 	  	Principal	 	  	Balance	 
	 1
	  	 	Jun-16	  	  	$	1,817.04	  	  	$	1,179.24	  	  	$	637.80	  	  	 	201,518.20	  
	 2
	  	 	Jul-16	  	  	$	1,817.04	  	  	$	1,175.52	  	  	$	641.52	  	  	 	200,876.68	  
	 3
	  	 	Aug-16	  	  	$	1,817.04	  	  	$	1,171.78	  	  	$	645.26	  	  	 	200,231.42	  
	 4
	  	 	Sep-16	  	  	$	1,817.04	  	  	$	1,168.02	  	  	$	649.02	  	  	 	199,582.40	  
	 5
	  	 	Oct-16	  	  	$	1,817.04	  	  	$	1,164.23	  	  	$	652.81	  	  	 	198,929.59	  
	 6
	  	 	Nov-16	  	  	$	1,817.04	  	  	$	1,160.42	  	  	$	656.62	  	  	 	198,272.97	  
	 7
	  	 	Dec-16	  	  	$	1,817.04	  	  	$	1,156.59	  	  	$	660.45	  	  	 	197,612.52	  
	 8
	  	 	Jan-17	  	  	$	1,817.04	  	  	$	1,152.74	  	  	$	664.30	  	  	 	196,948.22	  
	 9
	  	 	Feb-17	  	  	$	1,817.04	  	  	$	1,148.86	  	  	$	668.18	  	  	 	196,280.04	  
	 10
	  	 	Mar-17	  	  	$	1,817.04	  	  	$	1,144.97	  	  	$	672.07	  	  	 	195,607.97	  
	 11
	  	 	Apr-17	  	  	$	1,817.04	  	  	$	1,141.05	  	  	$	675.99	  	  	 	194,931.98	  
	 12
	  	 	May-17	  	  	$	1,817.04	  	  	$	1,137.10	  	  	$	679.94	  	  	 	194,252.04	  
	 13
	  	 	Jun-17	  	  	$	1,817.04	  	  	$	1,133.14	  	  	$	683.90	  	  	 	193,568.14	  
	 14
	  	 	Jul-17	  	  	$	1,817.04	  	  	$	1,129.15	  	  	$	687.89	  	  	 	192,880.25	  
	 15
	  	 	Aug-17	  	  	$	1,817.04	  	  	$	1,125.13	  	  	$	691.91	  	  	 	192,188.34	  
	 16
	  	 	Sep-17	  	  	$	1,817.04	  	  	$	1,121.10	  	  	$	695.94	  	  	 	191,492.40	  
	 17
	  	 	Oct-17	  	  	$	1,817.04	  	  	$	1,117.04	  	  	$	700.00	  	  	 	190,792.40	  
	 18
	  	 	Nov-17	  	  	$	1,817.04	  	  	$	1,112.96	  	  	$	704.08	  	  	 	190,088.32	  
	 19
	  	 	Dec-17	  	  	$	1,817.04	  	  	$	1,108.85	  	  	$	708.19	  	  	 	189,380.13	  
	 20
	  	 	Jan-18	  	  	$	1,817.04	  	  	$	1,104.72	  	  	$	712.32	  	  	 	188,667.81	  
	 21
	  	 	Feb-18	  	  	$	1,817.04	  	  	$	1,100.56	  	  	$	716.48	  	  	 	187,951.33	  
	 22
	  	 	Mar-18	  	  	$	1,817.04	  	  	$	1,096.38	  	  	$	720.66	  	  	 	187,230.67	  
	 23
	  	 	Apr-18	  	  	$	1,817.04	  	  	$	1,092.18	  	  	$	724.86	  	  	 	186,505.81	  
	 24
	  	 	May-18	  	  	$	1,817.04	  	  	$	1,087.95	  	  	$	729.09	  	  	 	185,776.72	  
	 25
	  	 	Jun-18	  	  	$	1,817.04	  	  	$	1,083.70	  	  	$	733.34	  	  	 	185,043.38