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###### Department of Defense

###### Office of the Secretary

          - [Docket ID: DoD-2023-HA-0082]

# AGENCY:

The Office of the Assistant Secretary of Defense for Health Affairs (OASD(HA)), Department of Defense (DoD).

# ACTION:

60-Day information collection notice.

# SUMMARY:

                        In compliance with the                         *Paperwork Reduction Act of 1995,*                         the Defense Health Agency announces a proposed public information collection and seeks public comment on the provisions thereof. Comments are invited on: whether the proposed collection of information is necessary for the proper performance of the functions of the agency, including whether the information shall have practical utility; the accuracy of the agency's estimate of the burden of the proposed information collection; ways to enhance the quality, utility, and clarity of the information to be collected; and ways to minimize the burden of the information collection on respondents, including through the use of automated collection techniques or other forms of information technology.                    

# DATES:

Consideration will be given to all comments received by November 13, 2023.

# ADDRESSES:

You may submit comments, identified by docket number and title, by any of the following methods:

*Federal eRulemaking Portal: http://www.regulations.gov.*                         Follow the instructions for submitting comments.                    

*Mail:*                         Department of Defense, Office of the Assistant to the Secretary of Defense for Privacy, Civil Liberties, and Transparency, 4800 Mark Center Drive, Mailbox #24, Suite 08D09, Alexandria, VA 22350-1700.                    

*Instructions:*                         All submissions received must include the agency name, docket number and title for this                         **Federal Register**                         document. The general policy for comments and other submissions from members of the public is to make these submissions available for public                               ( print page 63089)                            viewing on the internet at                         *http://www.regulations.gov*                         as they are received without change, including any personal identifiers or contact information.                    

# FOR FURTHER INFORMATION CONTACT:

To request more information on this proposed information collection or to obtain a copy of the proposal and associated collection instruments, please write to the Defense Health Agency, 7700 Arlington Blvd., Falls Church, VA 22042, Terry McDavid, 703-681-3645.

# SUPPLEMENTARY INFORMATION:

*Title; Associated Form; and OMB Number:*                     The Effect of Alcohol Intake on Resilience and Recovery Outcomes Using Alcohol Flush as an Instrumental Variable (Alcohol Flush); OMB Control Number 0720-FLSH.                

*Needs and Uses:*                     The study's objective is to investigate causal models of alcohol use on resilience measures (                    *e.g.,*                     posttraumatic stress disorder [PTSD]). This research objective will be accomplished by (a) collecting a self-report survey and (b) conducting genotyping and sequencing of DNA (potentially up to whole genomic sequencing) from samples of Active Duty Service Members (ADSM; ≥21 years old, n=999.). The compelling need for administration of the survey component of the                     *Alcohol Flush Study*                     rests on these four methodological requirements:                
    - Concurrent collection of demographics, research health information (RHI), and self-reported alcohol consumption
    - Avoid potential statistical confounding by implementing systematic data collection across all participants to address research questions and perform statistical modeling,
    - Ability to link survey data to genotyping and sequencing data,
    - Ability to re-contact participants for future research.

This research will deliver a knowledge product that will inform policy and practice in the Military Health System (MHS). We further expect to identify alcohol as a potential modifiable risk factor related to PTSD and other mental health conditions, which could go beyond the MHS into embedded mental health services for prevention and intervention for at-risk individuals. In the context of Precision Medicine, this survey establishes a cohort who may be contacted for participation in additional research, tailors medical care to optimize efficiency, effectiveness, safety, and patient-centeredness of therapeutic approaches using genetic profiling. The long-term impact of this study has the potential to lower inappropriate utilization, thus reducing costs while improving health-related quality of life and optimizing Readiness.

Information collected in this survey will be used for research purposes to fulfill the objectives of this grant-funded study which aligns to a requirement to “better understand the impact of alcohol use on resiliency and recovery.” The findings will be interpreted by a multidisciplinary team of physicians, scientists, behavioral psychologists, and healthcare services researchers to (a) inform policy and (b) make recommendations for practice in the contest of Precision Medicine.

*Affected Public:*                     Individuals and households.                

*Annual Burden Hours:*                     999.                

*Number of Respondents:*                     999.                

*Responses per Respondent:*                     1.                

*Annual Responses:*                     999.                

*Average Burden per Response:*                     1 Hour.                

*Frequency:*                     On occasion.                

Dated: September 5, 2023.

Aaron T. Siegel,

Alternate OSD Federal Register Liaison Officer, Department of Defense.

[FR Doc. 2023-19849 Filed 9-13-23; 8:45 am]

BILLING CODE 5001-06-P