Exhibit 10.10


 





[410 W Harrison/Third Amendment]


 


THIRD AMENDMENT TO LEASE


 


THIS THIRD AMENDMENT
TO LEASE (this "Third Amendment") is made as of _______October 1________, 2014 by and between ARE-SEATTLE
NO. 10, LLC, a Delaware limited liability company ("Landlord"), and PHASERX INC., a Delaware corporation
("Tenant").


 


RECITALS


 


A.           Landlord
and Tenant entered into that certain Lease Agreement dated as of February 9, 2010 (“Original Lease”), as amended
by that certain First Amendment to Lease dated as of July 1, 2010 (“First Amendment”) and that certain Second
Amendment to Lease Agreement dated as of April 4, 2011 (“Second Amendment”). The Original Lease as amended by
the First Amendment and the Second Amendment is hereinafter referred to as the "Lease". Pursuant to the Lease,
Tenant leases certain premises consisting of approximately 11,291 rentable square feet ("Premises") in a building
located at 410 West Harrison, Seattle, Washington. The Premises are more particularly described in the Lease. Capitalized terms
used herein without definition shall have the meanings defined for such terms in the Lease.


 


B.            Pursuant
to a letter dated September 30, 2011, Tenant exercised its Termination Right under Section 10 of the Second Amendment and
terminated its right to lease the Expansion Space (defined in the Second Amendment) prior to Landlord’s delivery of the Expansion
Space to Tenant.


 


C.            The Base
Term of the Lease expires on September 30, 2015.


 


D.           Landlord
and Tenant desire, subject to the terms and conditions set forth below, to amend the Lease to, among other things, (i) extend the
Base Term of the Lease for a period of 3 months to expire on December 31, 2015, (ii) extend the date by which Tenant must give
Landlord written notice of its election to exercise is Extension Right, and (iii) clarify that Tenant does not lease the Expansion
Space.


 


NOW, THEREFORE,
in consideration of the foregoing Recitals, which are incorporated herein by this reference, the mutual promises and conditions
contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged,
Landlord and Tenant hereby agree as follows:


 


		1.	Base Term. The Base Term of the Lease is
hereby extended to expire on December 31, 2015.



 


		2.	Rent. Tenant shall pay Base Rent through
the expiration of the Base Term of the Lease (as extended pursuant to Section 1 above), at the rates in effect on September 30,
2015. Tenant shall continue to pay Tenant’s Share of Operating Expenses and all other charges as set forth in the Lease.



 


		3.	Extension Right.



 


(a)          The
first sentence of the first paragraph of Section 40(a) of the Lease is hereby deleted in its entirety and replaced with the following:


 


“Tenant
shall have 1 right (an “Extension Right”) to extend the term of this Lease for 5 years (an “Extension
Term") on the same terms and conditions as this Lease (other than with respect to Base Rent and the Work Letter) by giving
Landlord written notice of its election to exercise the Extension Right on or before June 30, 2015.”


 




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[410 W Harrison/Third Amendment]


  


		(b)	The first sentence of the last paragraph of Section 40(a)
of the Lease is hereby deleted in its entirety and replaced with the following:



 


“lf,
on or before the date which is 120 days prior to the expiration of the Base Term of this Lease, Tenant
has not agreed with Landlord's determination of the Market Rate and the rent escalations during the Extension Term after negotiating
in good faith, Tenant shall be deemed to have elected arbitration as described in Section
40(b).”


 


		4.	No Right to the Expansion Space. For avoidance
of doubt, Sections 1-10 of the Second Amendment are hereby deleted the entirety and are of no further force of effect; provided,
however that Section 11 of the Second Amendment shall remain in full force and effect.



 


		5.	Brokers. Landlord and Tenant each represents
and warrants that it has not dealt with any broker, agent or other person (collectively, "Broker") in connection
with the transaction reflected in this Third Amendment and that no Broker brought about this transaction. Landlord and Tenant
each hereby agrees to indemnify and hold the other harmless from and against any claims by any Broker claiming a commission or
other form of compensation by virtue of having dealt with Tenant or Landlord, as applicable, with regard to this leasing transaction.



 


		6.	Miscellaneous.



 


a.           This
Third Amendment is the entire agreement between the parties with respect to the subject matter hereof and supersedes all prior
and contemporaneous oral and written agreements and discussions. This Third Amendment may be amended only by an agreement in writing,
signed by the parties hereto.


 


b.           This
Third Amendment is binding upon and shall inure to the benefit of the parties hereto, their respective agents, employees, representatives,
officers, directors, divisions, subsidiaries, affiliates, assigns, heirs, successors in interest and shareholders.


 


c.           Tenant
acknowledges that it has read the provisions of this Third Amendment, understands them, and is bound by them. Time is of the essence
in this Third Amendment.


 


d.           This
Third Amendment may be executed in any number of counterparts, each of which shall be deemed an original, but all of which when
taken together shall constitute one and the same instrument. The signature page of any counterpart may be detached therefrom without
impairing the legal effect of the signature(s) thereon provided such signature page is attached to any other counterpart identical
thereto except having additional signature pages executed by other parties to this Third Amendment attached thereto.


 


e.           Except
as amended and/or modified by this Third Amendment, the Lease is hereby ratified and confirmed and all other terms of the Lease
shall remain in full force and effect, unaltered and unchanged by this Third Amendment. In the event of any conflict between the
provisions of this Third Amendment and the provisions of the Lease, the provisions of this Third Amendment shall prevail. Whether
or not specifically amended by this Third Amendment, all of the terms and provisions of the Lease are hereby amended to the extent
necessary to give effect to the purpose and intent of this Third Amendment.


 


[Signatures are on the next page]


 




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[410 W Harrison/Third Amendment]


 


IN WITNESS WHEREOF,
the parties hereto have executed this Third Amendment as of the day and year first above written.


 


	 	TENANT:
	 	 
	 	PHASERX INC.,
	 	a Delaware corporation
	 	 	 
	 	By:	/s/ Robert W. Overell
	 	Its:	President & CEO


 


	 	LANDLORD:
	 	 	 
	 	ARE-SEATTLE NO. 10, LLC, 
	 	a Delaware limited liability company
	 	 	 	 	 
	 	By:	ALEXANDRIA REAL ESTATE EQUITIES, L.P., 
	 	 	a Delaware limited partnership, 
	 	 	managing member
	 	 	 
	 	 	By:	ARE-QRS CORP., 
	 	 	 	a Maryland corporation, 
	 	 	 	general partner
	 	 	 	 	 
	 	 	 	By:	/s/ Jackie Clem
	 	 	 	Its: 	Jackie
    Clem, VP Real Estate Legal Affairs


 




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