## U.S. Environmental Protection Agency October 2014



# TSCA Work Plan for Chemical Assessments : 2014 Update

Environmental Protection Agency

Office of Pollution Prevention and Toxics

October 2014

## U.S. Environmental Protection Agency October 2014

TSCA Work Plan for Chemical Assessments: 2014 Update 2 

# I. Overview

EPA is updating its list of existing chemicals for assessment under the Toxic Substances Control Act (TSCA); this is known as the TSCA Work Plan for Chemical Assessments . The changes to the TSCA Work Plan for Chemical Assessments reflect updated industry data submitted to EPA through the Toxics Release Inventory (TRI) in 2011 and th e TSCA Chemical Data Reporting (CDR) requirements in 2012 on chemical releases and potentia l exposures

. This is the first update to the TSCA Work Plan for Chemical Assessments , which EPA presented in early 2012. As newer data from TRI and CDR become available, EPA will update the TSCA Work Plan for Chemical Assessments. The Agency use s th is Work Plan to focus the activities of the Existing Chemicals Program in the Office of Pollution Prevention and Toxics (OPPT) so that existing chemicals having the highest potential for exposure and hazard are assessed

, and

, if warranted

, are subject to risk reduction actions

.

EPA notes that identification of a chemical on the TSCA Work Plan for Chemical Assessments does not itself constitute a finding by the Agency that the chemical presents a risk to human health or the environment. Rather, identification of a chemical on the TSCA Work Plan for Chemical Assessments indicates only that the Agency intends to consider it for assessment. The Agency believes that identifying these chemicals early in the review process would afford all interested parties the opportunity to bring additional relevant information on those chemicals to the Agency’s attention to further inform the assessment.

Identification of chemical s for the TSCA Work Plan for Chemical Assessments does not mean EPA would not consider other chemicals for assessment and potential risk reduction action under TSCA and other statutes ; for example, if a potential risk has been identified with a chemical or type of chemicals , EPA may consider these chemicals

. EPA will consider other chemicals if warranted by available information.

II. Background

The 2012 TSCA Work Plan for Chemical Assessments identifie d 83 chemicals for assessment by EPA as part of its chemical safety program

. The screening process for identifying these chemicals is based on a combination of hazard, exposure (including via uses )

, and persistence and bioaccumulation characteristics, and is described in the TSCA Work Plan Chemicals Methods Document

. The Agency continues to use this process

, which focuses on chemicals that meet one or more of the following factors:

 Potential concern for children’s health (for examp le, because of reproductive or

developmental effects)

 Neurotoxic effects

 Persistent, bioaccumulative and toxic

 Probable or known carcinogens

 Used in children’s products or in products to which children may be highly exposed

 Detected in biomonitoring progra ms.
EPA also considered other factors in determining whether a chemical should be included on the TSCA Work Plan for Chemical Assessments . Some chemicals identified as ‘high’ through this scoring system may not necessarily be practical candidates for assessment under TSCA when other information

## U.S. Environmental Protection Agency October 2014

TSCA Work Plan for Chemical Assessments: 2014 Update 3 

# is factored into the process. For example, the particular risks presented by certain chemicals m ay already be addressed by significant regulation under other statutes.

III. 2014 Update to the TSCA Work Plan for Chemical Assessments

EPA updated the TSCA W ork P lan for Chemical Assessments by using more recent information submitted in 2012 under the Chemical Data Reporting Rule (CDR) and data reported in 2011 to the Toxic s Release Inventory (TRI). These data were used to update the exposure ranking for the 345 existing chemicals that were generated under the two

- step screening process used i n the 2012 TSCA Work Plan for Chemical Assessments

. In 2012, the Agency used several sources to identify chemicals meeting prioritization factor criteria as potential candidates for review; a total of 1,235 chemicals were identified. This group was screene d to determine if any chemicals should be excluded because they are not subject to TSCA or there was already significant regulation under TSCA, or due to radioactivity, complex process streams, natural occurrence, or other properties. After these chemicals were excluded, 345 chemicals remained as potential candidates and entered the second stage of the Work Plan screening, which scored them under three characteristics: hazard, exposure, and potential for persistence and bioaccumulation. Details of how chemi cals were screened and criteria were used are in the TSCA Work Plan Chemicals: Methods Document

.

In addition to re

- screening the 345 chemicals identified in 2012 , EPA used the methodology developed for the TSCA Work Plan for Chemical Assessments to screen the Action Plan chemicals

, which were not part of the 2012 TSCA Work Plan for Chemical Assessments

, as well as two chemical flame retardants identified during EPA’s development of a flame retardant strategy

. Based on this assessment, EPA is removing 1 5 of the original chemicals in the TSCA Work Plan for Chemical Assessments , consolidating one chemical, and adding 2 3 chemicals to the 2014 update to the TSCA Work Plan for Chemical Assessments , including five Action Plan chemicals or groups

. The TSCA Work Plan for Chemical Assessments: 2014 Update contains 90 chemicals.

Completed Chemical Assessments

EPA has completed assessments for four chemicals that are on the TSCA Work Plan for Chemical Assessments :

 Trichloroethylene (TCE) : This risk assessment addresses trichloroethylene (TCE) as a degreaser, a spot

- cleaner in dry cleaning and a spray

- on protective coating. On June 25, 2014, EPA released the fina l risk assessment that identified health risks to consumers using spray aerosol degreasers and spray fixatives and to workers when TCE is used as a degreaser in small commercial shops and as a stain removing agent in dry cleaning.

 Methylene Chloride or Dichloromethane (DCM): This risk assessment addresses methylene chloride in paint stripper products. On August 28, 2014, EPA released the final risk assessm ent that indicates health risks to both workers and consumers who use these products, and to bystanders in workplaces and residences where methylene chloride is used.

## U.S. Environmental Protection Agency October 2014

TSCA Work Plan for Chemical Assessments: 2014 Update 4



#  1,3,4,6,7,8

- Hexahydro

- 4,6,6,7,8,8,

- hexamethylcyclopenta[γ]

- 2

- benzopyran (HHCB) : This risk assessment addresses ecological risks from HHCB as a fragrance ingredient in commercial and consumer products. On August 28, 2014, EPA released the fina l risk assessment that indicated no concern for this use of HHCB.

 Antimony Trioxide (ATO) : This risk assessment addresses effects on ecological receptors from the use of antimony trioxide (ATO) as a synergist in halogenated flame retardants. On August 28, 2014, EPA released the final risk assessment that indicated no concern for this use of ATO

.

a. Chemicals Added

i. Action Plan Chemicals

From 2009 to 2011, EPA published ten chemical Action Plans

. Five chemicals or groups of chemicals that scored ‘high’ under the methodology developed for the TSCA Work Plan for Chemical Assessments methodology for which EPA has Action Plans are now included in the TSCA Work Plan for assessment. EPA added the following Action Plan chemicals to the TSCA Work Plan for Chemical Assessments :

 B isphenol A (BPA)

 Decabromodiphenyl ether (decaBDE)

 H exabr o mocyclododecane (HBCD )

 N onylphenol s and nonylphenol ethoxylates (NP/NPE)

 Group of phthalates ( dibutyl phthalate ( DBP )

, butyl benzyl phthalate ( BBP )

, di

- (2

- ethylhexyl ) phthalate ( DEHP )

, di

- n

- octyl phthalate ( D n OP )

, di

- isononyl phthalate ( DINP )

, di

- isodecyl phthalate ( DIDP )

, and di

- isobutyl phthalate ( DIBP )

Though a July 2014 report provided to the U.S. Consumer Product Safety Commission (CPSC) by the Chronic Hazard Advisory Panel (CHAP) on Phthalates and Ph thalate Alternatives provided a risk assessment for the eight phthalates described in EPA’s Ac tion Plan, EPA is adding seven of these chemicals to the TSCA Work Plan for Chemical Assessments to determine whether any additional assessment is needed to supplement the report and address any TSCA

- specific uses or exposure scenarios. One phth a late, di

- n

- pentyl phthalate (DnPP) , is not being added since it is no longer in

commerce

.

Five of the ten Action Plan chemicals screened using the methodology of the TSCA Work Plan for Chemical Assessments will not be added to the TSCA Work Plan during this update

.

 Benzidine dyes are not being added to the 2014 update of the TSCA Work Plan for Chemical Assessments because they are only moderately persistent and bioaccumulative, and have not been found to be present in human biomonitoring. Thus, the current expos ure potential is considered low. EPA will propose a Significant New Use Rule for these chemicals so that the Agency can review any new uses before they are introduced into commerce.

 EPA has already begun risk management actions for long

- chain perfluori nated chemicals (PFCs), which rank high for hazard due to chronic and developmental toxicity. PFCs

## U.S. Environmental Protection Agency October 2014

TSCA Work Plan for Chemical Assessments: 2014 Update 5 

# bioaccumulate in wildlife and humans, and are persistent in the environment. Use of one subgroup of PFCs (sulfonates) was discontinued in the United States f rom 2002 to 2006; additionally, in 2006 EPA and the eight major companies in the industry launched the 2010/15 PFOA Stewardship Program in which companies committed to reduce global facility emissions and product content of PFOA and related chemicals by 95 percent by 2010, and to work toward eliminating emissions and product content by 2015. However, EPA remains concerned about PFCs being produced by companies not participating in the stewardship program. Currently, the Agency is interested in gathering add itional data regarding use of PFCs in imported articles before determining if these chemicals should be candidates for the assessment process.

 The diisocyanates methylene diphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) are not being added to the TSCA Work Plan for Chemical Assessments because they are not persistent and bioaccumulative , due to their reactivity, and are not found in house dust (factors considered in the Work P lan Methodology). EPA intends to issue a SNUR for TDI. Given the toxicity and potential exposure of these chemicals, EPA will consider if other risk management actions are needed for these chemicals.

 EPA is not adding short chain chlorinated paraffins because they are no longer domestically produced or impo rted into the United States.

ii. Other Chemicals Added

In addition to the five Action Plan chemicals or groups being added, EPA is adding ten chemicals to the TSCA Work Plan for Chemical Assessments that in 2012 had been considered of moderate priority for assessment based on the TSCA Work Plan Methodology

, and two chemicals that are part of a widely

- used flame retardant

.

Chemicals with an Increase in Score

Ten of the chemicals added are part of a group of 345 chemicals the Agency screened in 2012 during the development of the TSCA Work Plan for Chemical Assessments

. They are:

 1,3

- Butadiene

 2,5

- Furandione

 2

- Dimethylaminoethanol

 2

- Hydroxy

- 4

- (octyloxy)benzophenone

 3,3’

- Dichloro

- benzidine

 4,4'

- (1

- Methylethylidene)bis[2,6

- dibromophenol] (TBBPA)

 Barium carbonate

 Dicyclohexyl phthalate

 Molybdenum and Molybdenum Compounds

 Pentachlorothiophenol

In the scoring process for the 201 2 TSCA Work Plan for Chemical Assessments , these ten chemicals rece ived a score of ‘moderate

. ’ R ecent ly submitted CDR and TRI data (in 2012 and 2011, respectively) indicate that they are being domestically produced or imported in greater quantities and are being used in a larger variety of consumer and children’s products , leading to an increase in their

## U.S. Environmental Protection Agency October 2014

TSCA Work Plan for Chemical Assessments: 2014 Update 6 

# exposure score and a subsequent increase in their final score to ‘high’ under Step 2 of the screening process identified in the Methods Document for the TSCA Work Plan for Chemical Assessments

. Details of their scores and the reasons for adding them are available in the TSCA Work Plan for Chemical Assessments: 2014 Update (at the end of this document)

. Like the group of phthalates included in EPA’s Action Plans (and described earlier), dicyclohexyl phthalate (DCHP) is also covered in the CHAP report on phthalates to CPSC . It also scores high under the methodology of the TSCA Work Plan for Chemical Assess ments and will also be evaluated by EPA to determine if there are TSCA

- specific scenarios that should be assessed.

Flame Retardants

Triphenyl phosphate (TPP) and isopropylated phenol, phosphate (iPTPP) are being added, though they were not among the chemicals screened in 201 2 . They came to the Agency’s attention as part of EPA’s analysis of flame retardant chemicals . Because TPP and iPTPP meet the screening criteria detailed in the methodology developed for the TSCA Work Plan for Chemical Assessments

, they are being added to the TSCA Work Plan for Chemical Assessments: 2014 Update

.

b. Chemicals Removed or Consolidated

Chemicals No Longer in Commerce

O f the original 83 chemicals in the TSCA Work Plan for Chemical Assessments , 67 had no change or had a n increase in their potential exposure to people and the environment, and most continue to be on the TSCA Work Plan for Chemical Assessments . Thirteen chemicals are being removed from the TSCA Work Plan for Chemical Assessments because they are not currently in commerce based on data the Agency received under the C D R rule and as part of TRI reporting . Though these chemicals may be toxic, persistent and bioaccumulative, and may have been detected in human or environmental biomonitoring, they no lo nger present exposure potential from current consumer or commercial use

. Thus, t hey are being removed from the TSCA Work Plan for Chemical Assessments . The chemicals being removed are :

 1,2,4,5

- Tetrachloro

- benzene

 4

- Chloro

- 2

- methylaniline (p

- Chloro

- o

- tol uidine)

 Benz(a)anthracene

 Dibenz(a,h)anthracene

 Dibromochloromethane

 Dichloroacetic acid

 Hexabromobiphenyl

 Hexachlorocyclohexane

 N

- Nitroso

- ethylamine

 N

- Nitrosodimethylamine

 Pentabromophenol

 Polychlorinated naphthalenes

 Tris(2,3

- di bromopropyl) phosphate (TBP)

## U.S. Environmental Protection Agency October 2014

TSCA Work Plan for Chemical Assessments: 2014 Update 7 

# EPA will continue to review data submitted for these chemicals. If new data indicate that these chemicals have returned to commerce, the Agency will update the TSCA Work Plan for Chemical Assessments

. Special Cases

EPA is removing m ercury and mercury compounds from the TSCA Work Plan for Chemical Assessments because their hazards are already well characterized and EPA has a strong risk reduction effort in place. P rotecting human health and the environment by reducing exposures to mer cury and mercury compounds remains a priority for EPA, and the Agency has taken and continue s to take risk management measures for these chemicals , including efforts to implement the Minamata Convention

. T herefore, t he Agency does not believe that its risk management activities on mercury and mercury compounds need additional assessment under the process for the TSCA Work Plan for Chemical Assessments

. EPA is also removing quartz from the TSCA Work Plan for Chemical Assessments because it presents a hazard only in the context of silicosis from the inhalation of very fine crystalline dust particles, which might occur only during such occupational activities as sandblasting or stone cutting; these potential exposures are specifically controlled under regulati ons issued by the Occupational Sa fety and Health Administration

. Polycyclic Aromatic Hydrocarbons

B enzo[a]pyrene is part of a group of polycyclic aromatic hydrocarbons (PAHs)

. EPA believes this chemical and other PAHs should be assessed as a category rather than as individual chemical substances. The exposure and release information EPA receives about PAHs is generally reported as a mixture of several PAHs , and not as individual chemicals. T he Agency will evaluate several PAHs

, including benzo[a]pyrene

, as part of a n assessment of creosote under the TSCA W ork P lan for Chemical Assessments

. Additional individual PAHs previously on the TSCA Work Plan for Chemical Assessments are being removed since they are no longer in commerce

.

c. TSCA Work Plan for Chemical Assessments: 2014 Update

See table on next page.

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

1 Acetaldehyde Added 2012 Possible human carcinogen 3 Used in consumer products Present in drinking water, indoor environments, ambient air, and groundwater High reported releases to the environment 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Industrial Not yet initiated 75-07-0

2 Acrylonitrile Added 2012 Probable human carcinogen 3 Widely used in consumer products Present in indoor environments, surface water, ambient air, and groundwater High reported releases to the environment 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Dispersive Industrial Not yet initiated 107-13-1

3 tert-Amyl methyl ether Added 2012 Chronic toxicity Central nervous system effects Potential carcinogenicity to specific target organs 2 Widely used in consumer products Present in drinking water, surface water, and ambient air Estimated to have moderate releases to the environment 3 Moderate environmental persistence Low bioaccumulation potential 2 Consumer Industrial Not yet initiated 994-05-8 

### This document updates the June 2012 TSCA Work Plan for Chemical Assessment. The TSCA Work Plan Chemicals Methods Document explains the hazard, exposure, and persistence/bioaccumulation criteria, the data sources used, and how chemicals were scored. The 2014 Update describes why changes were made. 

# TSCA Work Plan for Chemicals Assessments: 2014 Update

Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 1

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

4 Anthra[2,1,9-def:6,5,10-d'e'f'] diisoquinoline1,3,8,10(2H,9H)-tetrone (Pigment Violet 29) Added 2012 Aquatic toxicity 3* Widely used in consumer products Estimated to have moderate releases to the environment 3 High environmental persistence Low bioaccumulation potential 2 Consumer Industrial Not yet initiated 81-33-4

5 Antimony & Antimony Compounds Added 2012 Possible human carcinogen Developmental and reproductive toxicity Acute and chronic toxicity from inhalation exposures 3 Widely used in

consumer products Present in biomonitoring, drinking water, surface water, ambient air, and soil High reported releases to the environment 3 High environmental persistence Moderate bioaccumulation potential 3 Consumer Industrial Final

assessment complete August 2014 Category

6 Arsenic & Arsenic Compounds Added 2012 Known human carcinogens Neurotoxicity Central nervous system effects Acute and chronic toxicity from inhalation exposures 3 Widely used in consumer products Present in biomonitoring, drinking water, surface water, ambient air, soil High reported releases to the environment 2 High environmental persistence Low bioaccumulation potential 2 Consumer Industrial Not yet initiated Category

7 Asbestos & Asbestoslike Fibers Added 2012 Known human carcinogens Acute and chronic toxicity from inhalation exposures 3 Widely used in consumer products Present in indoor environments 3 High environmental persistence Low bioaccumulation potential 2 Consumer Industrial Not yet initiated Category



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 2

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

8 Barium Carbonate Added 2014 Acute toxicity 3 Used to manufacture paper, special glass, ceramics, bricks, enamels, paints, rubber, electrodes, and barium salts; used in oil well drilling, especially through gypsum; used in brines as a precipitant 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Industrial Not yet initiated 513-77-9

9 Benzenamine Added 2012 Probable human carcinogen 3 Used in consumer products Present in ambient air, groundwater, and soil High reported releases to the environment 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Industrial Not yet initiated 62-53-3

10 Benzene Added 2012 Known human carcinogen 3 Widely used in consumer products Present in biomonitoring, drinking water, indoor environments, surface water, ambient air, groundwater, soil High reported releases to the environment 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Dispersive Industrial Not yet initiated 71-43-2



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 3

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

11 Bisphenol A (BPA) Added 2014 Reproductive toxicity 3 Electrical and electronics equipment, optical media, linings in drinking water pipes, thermal paper coatings, automotive and transportation equipment 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Industrial Not yet initiated 80-05-7

12 1-Bromopropane Added 2012 Possible human carcinogen 3 Widely used in consumer products Present in drinking water, indoor environments, surface water, ambient air, groundwater, soil Estimated to have high releases to the environment 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Dispersive Industrial Initiated 2013 106-94-5

13 1,3-Butadiene Added 2014 Known human carcinogen 3 Major commodity product of the petrochemical industry, usuallyproduced as a byproduct of ethylene Increasing usage in the formation of rocket fuels, plastics, resins, and commercial latex paints Reported uses in plastic products, textiles, apparel 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Industrial Not yet initiated 106-99-0



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 4

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

14 Butanamide, 2,2'-[(3,3'- dichloro[1,1'- biphenyl]- 4,4'-diyl)bis(azo)]bis[N- (4-chloro-2,5 - dimethoxyphenyl)-3-oxo- (Pigment Yellow 83) Added 2012 Acute toxicity 2 Used in consumer products Estimated to have high releases to the environment 3 High environmental persistence High bioaccumulation potential 3 Consumer Industrial Not yet initiated 5567-15-7

15 Butanamide, 2-[(4- methoxy-2-nitrophenyl) azo]-N-(2- methoxyphenyl)-3-oxo- (Pigment Yellow 65) Added 2012 Aquatic toxicity 3* Widely used in consumer products Estimated to have high releases to the environment 3 High environmental persistence Low bioaccumulation potential 2 Consumer Not yet initiated 6528-34-3

16 Butyl benzyl phthalate (BBP)1,2-Benzenedicarboxylic acid, 1- butyl 2(phenylmethyl) ester Added 2014 Chronic aquatic toxicity 3 Most widely used stain-resistant plasticizer in poly(vinyl chloride) Widely used in vinyl tile Used in commercial/ industrial products 3 Low environmental persistence Low bioaccumulation potential 1 Industrial Commercial Consumer Not yet initiated 85-68-7

17 4-sec-Butyl-2,6-di-tertbutylphenol Added 2012 Chronic toxicity 2 Widely used in consumer products Estimated to have moderate releases to the environment 3 Moderate environmental persistence Moderate bioaccumulation potential 2 Consumer Industrial Not yet initiated 17540-75-9



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 5

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

18 Cadmium & Cadmium Compounds Added 2012 Known human carcinogens Chronic cardiovascular, renal and musculoskeletal effects Acute and chronic toxicity from inhalation exposures 3 Widely used in consumer products Present in biomonitoring, drinking water, surface water, ambient air, soil High reported releases to the environment 3 High environmental persistence Moderate bioaccumulation potential 3 Consumer Industrial Not yet initiated Category

19 Carbon tetrachloride Added 2012 Probable human carcinogen 3 Used in commercial/industri al products Present in biomonitoring, drinking water, indoor environments, surface water, ambient air, groundwater, soil High reported releases to the environment 3 High environmental persistence Low bioaccumulation potential 2 Industrial Not yet initiated 56-23-5

20 Chromium & Chromium Compounds Added 2012 Known human carcinogens Reproductive toxicity Developmental toxicity Acute and chronic toxicity from inhalation exposures 3 Used in commercial/ industrial products Present in ambient air High reported releases to the environment 1 High environmental persistence Moderate bioaccumulation potential 3 Industrial Not yet initiated Category



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 6

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

21 Cobalt & Cobalt Compounds Added 2012 Cardiovascular and central nervous system effects Acute and chronic toxicity from inhalation exposures 3 Used in consumer products Present in biomonitoring, surface water, ambient air, soil High reported releases to the environment 3 High environmental persistence Moderate bioaccumulation potential 3 Industrial Not yet initiated Category

22 Creosotes Added 2012 Probable human carcinogen 3 Widely used in consumer products Present in groundwater, soil High reported releases to the environment 3 Moderate environmental persistence Moderate bioaccumulation potential 2 Industrial Not yet initiated 8001-58-9

23 Cyanide Compounds (Limited to dissociable compounds) Added 2012 Neurotoxicity Reproductive toxicity Central nervous system effects 3 Widely used in consumer products Present in drinking water, surface water, and soil High reported releases to the environment 3 Moderate environmental persistence Low bioaccumulation potential 2 Consumer Industrial Not yet initiated Category



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 7

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

24 Decabromodiphenyl ethers (DecaBDE) Added 2014 Developmental toxicity Aquatic toxicity 3 Has been widely used in textiles, plastics and polyurethane foam as flame retardants Articles which were often treated with PBDEs include textiles such as carpets and upholstery fabric; cushions; plastics used as components in electrical appliances, devices, and equipment in consumer, commercial, and industrial use; and building and construction materials 3 High environmental persistence High bioaccumulation potential 3 Consumer Commercial Industrial Not yet initiated 1163-19-5

25 Dibutyl phthalate (DBP)(1,2-Benzenedicarboxylic acid, 1,2- dibutyl ester) Added 2014 Chronic aquatic toxicity 3 Used in cosmetics, medical supplies, textiles, propellant, food packaging, dental material, and paper Used in the manufacture of plastics, paints, wood varnishes, and lacquers 3 Low environmental persistence Low bioaccumulation potential 1 Industrial Commercial Consumer Not yet initiated 84-74-2



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 8

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

26 o-Dichlorobenzene Added 2012 Chronic toxicity 2 Widely used in consumer products Present in biomonitoring, drinking water, indoor environments, surface water, ambient air and groundwater Moderate reported releases to the environment 3 Moderate environmental persistence Low bioaccumulation potential 2 Consumer Dispersive Industrial Not yet initiated 95-50-1

27 p-Dichlorobenzene Added 2012 Possible human carcinogen 3 Widely used in consumer products Present in biomonitoring, drinking water, ambient air, surface water, groundwater, soil Moderate reported releases to the environment 3 Moderate environmental persistence Low bioaccumulation potential 2 Consumer Industrial Not yet initiated 106-46-7

28 3,3'-Dichlorobenzidine Added 2014 Probable human carcinogen 3 Used in the production of dyes 2 Moderate environmental persistence Low bioaccumulation potential 2 Industrial Not yet initiated 91-94-1

29 3,3'-Dichlorobenzidine dihydrochloride Added 2012 Probable human carcinogen 3 Used in consumer products Relatively small reported releases to the environment 2 Moderate environmental persistence Low bioaccumulation potential 2 Consumer Industrial Not yet initiated 612-83-9



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 9

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

30 1,1-Dichloroethane Added 2012 Mutagenicity 2 Used in consumer products Present in biomonitoring, drinking water, surface water, ambient air, groundwater, soil Moderate reported releases to the environment 3 Moderate environmental persistence Low bioaccumulation potential 2 Consumer Industrial Not yet initiated 75-34-3

31 1,2-Dichloroethane Added 2012 Possible human carcinogen 3 Used in commercial/industri al products Present in biomonitoring, drinking water, indoor environments, surface water, ambient air, groundwater, soil High reported releases to the environment 3 Moderate environmental persistence Low bioaccumulation potential 2 Consumer Industrial Not yet initiated 107-06-2

32 trans-1,2- Dichloroethylene Added 2012 Chronic toxicity 2 Widely used in consumer products Present in biomonitoring, drinking water, surface water, ambient air, groundwater, soil 3 Moderate environmental persistence Low bioaccumulation potential 2 Consumer Industrial Not yet initiated 156-60-5



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 10

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

33 1,2-Dichloropropane Added 2012 Acute mammalian toxicity 2 Used in consumer products Present in biomonitoring, drinking water, indoor environments, surface water, ambient air, groundwater, soil High reported releases to the environment 3 High environmental persistence Low bioaccumulation potential 2 Consumer Industrial Not yet initiated 78-87-5

34 Dicyclohexyl phthalate Added 2014 Acute and chronic aquatic toxicity 3* Plasticizer; heat sealer for cellulose; heat sealer for paper finishes (labels, pharmaceutical labels, price labels) 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Industrial Not yet initiated 84-61-7

35 Di-ethylhexyl phthalate (DEHP)(1,2-Benzenedicarboxylic acid, 1,2- bis(2-ethylhexyl) ester ) Added 2014 Chronic aquatic toxicity 3 Widely used in medical devices, such as intravenous tubing and blood bags Widely used in consumer productsand constructionrelated products 3 Low environmental persistence Low bioaccumulation potential 1 Industrial Commercial Consumer Not yet initiated 117-81-7



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 11

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

36 Di-isobutyl phthalate (DIBP)(1,2-Benzenedicarboxylic acid, 1,2- bis-(2methylpropyl) ester) Added 2014 Reproductive toxicity 1 Specialty plasticizer often combined with other phthalates Used in printing inks Used in nitrocellulose, cellulose ether, and polyacrylate and polyacetate dispersions 2 Low environmental persistence Low bioaccumulation potential 1 Industrial Commercial Consumer Not yet initiated 84-69-5

37 Di-isodecyl phthalate (DIDP)(1,2-Benzenedicarboxylic acid, 1,2- diisodecyl ester) Added 2014 Developmental toxicity 3 Used in cosmetics, medical supplies, textiles, propellant, food packaging, dental material, and paper Used in the manufacture of plastics, paints, wood varnishes, and lacquers 3 Low environmental persistence Low bioaccumulation potential 1 Industrial Commercial Consumer Not yet initiated 26761-40-0

38 Di-isononyl phthalate (DINP)(1,2-Benzenedicarboxylic acid, 1,2- diisononyl ester) Added 2014 Developmental toxicity 2 Commonly used as plasticizer in poly(vinyl chloride) applications 3 Low environmental persistence Low bioaccumulation potential 1 Industrial Commercial Consumer Not yet initiated 28553-12-0

39 1,2-Dimethoxyethane (Monoglyme) Added 2012 Reproductive toxicity Developmental toxicity Chronic toxicity 3 Widely used in consumer products Estimated to have high releases to the environment 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Industrial Not yet initiated 110-71-4



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 12

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

40 2- Dimethylaminoethanol Added 2014 Acute toxicity 3 Intermediate in the synthesis of dyestuffs, textile, auxiliaries, pharmaceuticals and corrosion inhibitors, emulsifiers in paints and coatings Some uses in adhesives and sealants 3 Low environmental persistence Low bioaccumulation potential 1 Industrial Not yet initiated 108-01-0

41 Di-n-octyl phthalate (DnOP)(1,2-Benzenedicarboxylic acid, 1,2- dioctyl ester) Added 2014 Reproductive toxicity 2 Commonly used as plasticizer in poly(vinyl chloride) applications 3 Low environmental persistence Low bioaccumulation potential 1 Industrial Commercial Consumer Not yet initiated 117-84-0

42 1,4-Dioxane Added 2012 Possible human carcinogen 3 Widely used in consumer products Present in groundwater, ambient air and indoor environments High reported releases to the environment 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Dispersive Industrial Initiated 2014 123-91-1

43 Ethanone, 1- (1,2,3,4,5,6,7,8- octahydro-2,3,5,5- tetramethyl-2- naphthalenyl)- Added 2012 Aquatic toxicity 3* Widely used in consumer products Estimated to have high releases to the environment 3 Moderate environmental persistence High bioaccumulation potential 3 Consumer Industrial Not yet initiated 54464-59-4

44 Ethanone, 1- (1,2,3,4,5,6,7,8- octahydro-2,3,8,8- tetramethyl-2- naphthalenyl)- Added 2012 Aquatic toxicity 1* Widely used in consumer products Estimated to have high releases to the environment 3 Moderate environmental persistence High bioaccumulation potential 3 Consumer Industrial Not yet initiated 54464-57-2



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 13

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

45 Ethanone, 1-(1,2,3,4,6,7,8,8aoctahydro- 2,3,8,8- tetramethyl-2- naphthalenyl)- Added 2012 Aquatic toxicity 3* Widely used in consumer products Estimated to have high releases to the environment 3 Moderate environmental persistence Moderate bioaccumulation potential 2 Consumer Industrial Not yet initiated 68155-67-9

46 Ethanone, 1-(1,2,3,5,6,7,8,8aoctahydro- 2,3,8,8- tetramethyl-2- naphthalenyl)- Added 2012 Aquatic toxicity 3* Widely used in consumer products Estimated to have high releases to the environment 3 Moderate environmental persistence Moderate bioaccumulation potential 2 Consumer Industrial Not yet initiated 68155-66-8

47 Ethylbenzene Added 2012 Possible human carcinogen 3 Used in consumer products Present in biomonitoring, drinking water, indoor environments, surface water, ambient air, groundwater, soil High reported releases to the environment 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Industrial Not yet initiated 100-41-4

48 Ethylene dibromide Added 2012 Probable human carcinogen 3 Used in commercial/industri al products Present in drinking water, indoor environments, surface water, ambient air, groundwater, soil Relatively small reported releases to the environment 2 Moderate environmental persistence Low bioaccumulation potential 2 Consumer Industrial Not yet initiated 106-93-4



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 14

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

49 bis(2-Ethylhexyl) adipate Added 2012 Possible human carcinogen 3 Widely used in consumer products Present in drinking water, and indoor environments Estimated to have high releases to the environment 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Industrial Not yet initiated 103-23-1

50 2-Ethylhexyl 2,3,4,5- tetrabromobenzoate (TBB) Added 2012 Developmental toxicity Acute and chronic aquatic toxicity 2 Used in consumer products Present in indoor environments and soil 3 Moderate environmental persistence Moderate bioaccumulation potential 2 Consumer Industrial Initiated 2013 183658-27-7

51 bis(2-Ethylhexyl) - 3,4,5,6- tetrabromophthalate (TBPH) Added 2012 Developmental toxicity Acute and chronic aquatic toxicity 2 Used in consumer products Present in indoor environments Estimated to have moderate releases to the environment 3 Moderate environmental persistence Moderate bioaccumulation potential 2 Consumer Industrial Initiated 2013 26040-51-7

52 Formaldehyde Added 2012 Known human carcinogen 3 Used in consumer products Present in indoor environments, drinking water, ambient air, and groundwater High reported releases to the environment 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Industrial Not yet initiated 50-00-0



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 15

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

53 2,5-Furandione Added 2014 Acute and chronic aquatic toxicity 3* Chemical intermediate for thousands of substances including lubricating oil additives, personal care products, adhesives, floor polishes, water treatment chemicals, detergents, paper sizing, epoxy curing agents, and leather treatment 3 Low environmental persistence Low bioaccumulation potential 1 Industrial Not yet initiated 108-31-6

54 Hexabromocyclododec ane (HBCD) Added 2014 Acute aquatic toxcity 3* Flame retardant in extruded polystyrene foam, textiles, and elctrical and electronic appliances 3 High environmental persistence High bioaccumulation potential 3 Consumer Initiated 2013 3194-55-6

55 Hexachlorobutadiene Added 2012 Possible human carcinogen 3 Present in indoor environments, surface water, ambient air, groundwater, soil Relatively small reported releases to the environment 2 High environmental persistence High bioaccumulation potential 3 Industrial Not yet initiated 87-68-3

56 1-Hexadecanol Added 2012 Chronic toxicity 2 Widely used in consumer products Present in surface water, ambient air, and soil Estimated to have high releases to the environment 3 Low environmental persistence Moderate bioaccumulation potential 2 Consumer Dispersive Industrial Not yet initiated 36653-82-4



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 16

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

57 1,3,4,6,7,8-Hexahydro4,6,6,7,8,8- hexamethylcyclopenta [g]-2-benzopyran (HHCB) Added 2012 Developmental toxicity 2 Widely used in

consumer products Present in biomonitoring Estimated to have high releases to the environment 3 Moderate environmental persistence Moderate bioaccumulation potential 2 Consumer Dispersive Final

assessment complete August 2014 1222-05-5

58 2-Hydroxy-4-(octyloxy) benzophenone Added 2014 Acute and chronic aquatic toxicity 3* UV stablizer for polymers; used in rubber and plastic products Numerous food packaging uses (especially as a stablizer for petroleum wax) 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Commercial Not yet initiated 1843-05-6

59 Lead & Lead Compounds Added 2012 Neurotoxicity Developmental toxicity Reproductive toxicity 3 Widely used in consumer products Present in biomonitoring, drinking water, indoor environments, surface water, ambient air, soil High reported releases to the environment 3 High environmental persistence Moderate bioaccumulation potential 3 Consumer Industrial Not yet initiated Category

60 Long-chain chlorinated paraffins (C18-20) Added 2012 Chronic toxicity to target organs including the liver, kidneys and thyroid Aquatic toxicity 2 Present in biomonitoring, surface water, and soil Used in commercial/ industrial products 2 High environmental persistence High bioaccumulation potential 3 Industrial Dispersive Initiated 2012 Category



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 17

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

61 Medium-chain chlorinated paraffins (C14-17) Added 2012 Chronic toxicity to target organs including the liver, kidneys and thyroid Aquatic toxicity 2 Used in consumer products Estimated to have high releases to the environment 2 High environmental persistence High bioaccumulation potential 3 Consumer Dispersive Industrial Initiated 2012 Category

62 Methylene chloride Added 2012 Probable human carcinogen 3 Widely used in

consumer products Present in drinking water, indoor environments, ambient air, groundwater, and soil High reported releases to the 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Industrial Final

assessment complete August 2014. Pursuing risk reduction 75-09-2

63 4,4'-Methylene bis(2- chloroaniline) Added 2012 Known human carcinogen 3 Widely used in consumer products Present only in ambient air Relatively small reported releases to the environment 2 Moderate environmental persistence Low bioaccumulation potential 2 Consumer Industrial Not yet initiated 101-14-4

64 4,4'-(1- Methylethylidene)bis[2, 6-dibromophenol] (TBBPA) Added 2014 Acute aquatic toxcity 2* Flame retardant in epoxy resin circuit boards and in electronic enclosures 3 High environmental persistence Low bioaccumulation potential 2 Consumer Not yet initiated 79-94-7

65 N-Methyl-2-pyrrolidone (NMP) Added 2012 Reproductive toxicity 3 Widely used in consumer products Present in drikning water and indoor environments High reported releases to the environment 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Industrial Initiated 2012 872-50-4



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 18

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

66 Molybdenum and Molybdenum Compounds Added 2014 Chronic toxicity 1 Alloying agent in cast iron, steel, and super alloys to increase hardenability, strength, toughness, and corrosion resistance Used for electrical lead-in (in halogen lamps and electricfurnaces) and wearresistant coatings for machine & engine parts Also used in glass and nuclear energy industries 3 High environmental persistence Moderate bioaccumulation potential 3 Consumer Industrial Not yet initiated Category

67 Naphthalene Added 2012 Possible human carcinogen 3 Widely used in consumer products Present in biomonitoring, drinking water, indoor environments, surface water, ambient air, groundwater, soil High reported releases to the environment 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Industrial Not yet initiated 91-20-3

68 2- Naphthalenecarboxylic acid, 4-[(4-chloro-5- methyl-2-sulfophenyl) azo]-3-hydroxy-, calcium salt (1:1) (Pigment Red 52) Added 2012 Aquatic toxicity 3* Widely used in consumer products Estimated to have moderate releases to the environment 2 High environmental persistence Low bioaccumulation potential 2 Consumer Industrial Not yet initiated 17852-99-2



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 19

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

69 Nickel & Nickel Compounds Added 2012 Known human carcinogens Acute and chronic toxicity from inhalation exposures 3 Used in consumer products Present in ambient air High reported releases to the environment 2 High environmental persistence Low bioaccumulation potential 2 Consumer Industrial Not yet initiated Category

70 N-Nitrosodiphenylamine Added 2012 Probable human carcinogen 3 Used in consumer products Present in surface water, groundwater, soil Relatively small reported releases to the environment 2 Moderate environmental persistence Low bioaccumulation potential 2 Consumer Industrial Not yet initiated 86-30-6

71 Nonylphenol and Nonylphenol Ethoxylates (NP/NPEs) Added 2014 Reproductive toxicity Developmental toxicity Aquatic toxicity 3 In industrial detergents as well as other cleaners, degreasers (some for consumer use), and dry cleaning Industrial uses include petroleum dispersants, emulsifiers, wetting agents, adhesives, paper and textile processing formulations, prewash spotters, metalworking fluids, some paints and coatings, and dust control agents 3 Moderate environmental persistence Moderate bioaccumulation potential 2 Commercial Industrial Not yet initiated Category



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 20

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

72 Octamethylcyclotetrasiloxane (D4) Added 2012 Reproductive toxicity 2 Used in consumer products Present in biomonitoring, drinking water, indoor environments, and surface water Estimated to have high releases to the environment 3 Moderate environmental persistence High bioaccumulation potential 3 Consumer Dispersive Industrial Initiated 2012 556-67-2

73 4-tert-Octylphenol (4-(1,1,3,3- Tetramethylbutyl)- phenol) Added 2012 Aquatic toxicity 3* Used in consumer products Present in biomonitoring and drinking water Estimated to have moderate releases to the environment 3 High environmental persistence Moderate bioaccumulation potential 2 Consumer Industrial Not yet initiated 140-66-9

74 p,p'- Oxybis(benzenesulfonyl hydrazide) Added 2012 Reproductive toxicity Mutagenicity 3 Used in consumer products Estimated to have moderate releases to the environment 3 Moderate environmental persistence Low bioaccumulation potential 2 Consumer Not yet initiated 80-51-3

75 Pentachlorothio-phenol Added 2014 Acute and chronic toxicity 3 A mercaptan(sulfur) crosslinking agent that makes rubber more pliable 1 High environmental persistence High bioaccumulation potential 3 Industrial Not yet initiated 133-49-3

76 Phenol, isopropylated, phosphate (3:1) (iPTPP) Added 2014 Neurotoxicity Aquatic toxicity 3 Widely used as a flame retardant 3 High environmental persistence High bioaccumulation potential 3 Consumer Industrial Not yet initiated 68937-41-7



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 21

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

77 Phosphoric acid, triphenyl ester (TPP) Added 2014 Acute and chronic aquatic toxicity 3* Widely used as a flame retardant in polyurethane foam, PVC, printed wiring boards, children's products Applications inpolymers in highimpact polystyrenes, epoxy resins, and adhesives (minor use) 3 Moderate environmental persistence Moderate bioaccumulation potential 2 Consumer Industrial Not yet initiated 115-86-6

78 Phthalic anhydride Added 2012 Respiratory sensitizer 3 Widely used in consumer products Present in groundwater and ambient air High reported releases to the environment 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Industrial Not yet initiated 85-44-9

79 Styrene Added 2012 Possible human carcinogen Central nervous system effects 3 Widely used in consumer products Present in biomonitoring, drinking water, indoor environments, surface water, ambient air, and groundwater, soil High reported releases to the environment 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Industrial Not yet initiated 100-42-5



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 22

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

80 Tetrachloroethylene (PERC) Added 2012 Probable human carcinogen 3 Widely used in consumer products Present in biomonitoring, drinking water, indoor environments, ambient air, groundwater, soil High reported releases to the environment 3 High environmental persistence Low bioaccumulation potential 2 Consumer Dispersive Industrial Not yet initiated 127-18-4

81 Tribromomethane (Bromoform) Added 2012 Probable human carcinogen 3 Used in consumer products Present in biomonitoring, drinking water, surface water, ambient air, and groundwater Moderate reported releases to the environment 3 Moderate environmental persistence Low bioaccumulation potential 2 Consumer Industrial Not yet initiated 75-25-2

82 1,1,2-Trichloroethane Added 2012 Possible human carcinogen 3 Widely used consumer products Present in biomonitoring, drinking water, surface water, ambient air, groundwater, and soil Moderate reported releases to the environment 2 High environmental persistence Low bioaccumulation potential 2 Dispersive Not yet initiated 79-00-5



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 23

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

83 Trichloroethylene (TCE) Added 2012 Probable human carcinogen 3 Widely used in

consumer products Present in drinking water, indoor environments, surface water, ambient air, groundwater, and soil 3 High environmental persistence Low bioaccumulation potential 2 Consumer Industrial Final

assessment complete June 2014. Pursuing risk reduction 79-01-6

84 Triglycidyl isocyanurate Added 2012 Reproductive toxicity Mutagenicity Acute toxicity from inhalation exposures 3 Widely used in consumer products Estimated to have high releases to the environment 3 Moderate environmental persistence Low bioaccumulation potential 1 Consumer Industrial Not yet initiated 2451-62-9

85 Tris(2-chloroethyl) phosphate (TCEP) Added 2012 Mutagenicity Limited evidence of carcinogenicity 2 Widely used in consumer products Present in drinking water, and indoor environments Estimated to have moderate releases to the environment 2 Moderate environmental persistence Low bioaccumulation potential 2 Consumer Industrial Initiated 2013 115-96-8

86 2,4,6-Tris(

- tertbutyl)phenol Added 2012 Chronic toxicity and liver effects 2 Widely used in consumer products Present in indoor environments Estimated to have moderate releases to the environment 2 Moderate environmental persistence High bioaccumulation potential 3 Consumer Industrial Not yet initiated 732-26-3



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 24

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

87 Vinyl chloride Added 2012 Known human carcinogen 3 Used in consumer products Present in drinking water, indoor environments, surface water, ambient air, groundwater, soil High reported releases to the environment 3 Moderate environmental persistence Low bioaccumulation potential 2 Consumer Industrial Not yet initiated 75-01-4

88 m-Xylene Added 2012 Reproductive toxicity Developmental toxicity 3 Widely used in consumer products Present in biomonitoring, drinking water, surface water, ambient air, groundwater, soil High reported releases to the environment 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Industrial Not yet initiated 108-38-3

89 o-Xylene Added 2012 Chronic toxicity 3 Used in consumer products Present in biomonitoring, drinking water, indoor environments, surface water, ambient air, groundwater, soil High reported releases to the environment 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Industrial Not yet initiated 95-47-6



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 25

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

90 p-Xylene Added 2012 Reproductive toxicity 3 Widely used in consumer products Present in biomonitoring, drinking water, surface water, ambient air, groundwater, soil High reported releases to the environment 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Industrial Not yet initiated 106-42-3

Chemical Name When was the chemical added and removed? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status or Other Action CASRN

1 Benz[a]anthracene Added 2012 Removed 2014 Probable human

carcinogen 3 Present in biomonitoring, indoor environments, surface water, ambient air, groundwater, and soil 2 High environmental persistence Moderate bioaccumulation potential 3 Dispersive Industrial No assessment 56-55-3

2 p-Chloro-o-toluidine Added 2012 Removed 2014 Probable human

carcinogen 3 Present in biomonitoring, surface water, and soil 2 Moderate environmental persistence Low bioaccumulation potential 2 Industrial No assessment 95-69-2

3 Dibenz(a,h)anthracene Added 2012 Removed 2014 Probable human

carcinogen 3 Present in indoor environments, surface water, ambient air, groundwater, and soil 2 Moderate environmental persistence Moderate bioaccumulation potential 2 Dispersive No assessment 53-70-3 

# TSCA Work Plan Chemicals for Assessment: 2014 Update - Chemicals Removed or Consolidated

Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 26

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

4 Dibromochloromethane Added 2012 Removed 2014 Possible human

carcinogen 3 Present in biomonitoring, surface water, ambient air, and soil 2 Moderate environmental persistence Low bioaccumulation potential 2 Industrial No assessment 124-48-1

5 Dichloroacetic acid Added 2012 Removed 2014 Possible human

carcinogen 3 Used in consumer products Present in drinking water 3 Low environmental persistence Low bioaccumulation potential 1 Consumer Industrial No assessment 79-43-6

6 Hexabromobiphenyl Added 2012 Removed 2014 Possible human

carcinogen 3 Used in consumer products Present in ambient air and soil 2 High environmental persistence High bioaccumulation potential 3 Industrial No assessment 36355-01-8

7 Hexachlorocyclohexane Added 2012 Removed 2014 Possible human

carcinogen 3 Present in biomonitoring and surface water 2 High environmental persistence Moderate bioaccumulation potential 3 Industrial No assessment 608-73-1

8 Mercury & Mercury Compounds Added 2012 Removed 2014 Neurotoxicity

Developmental toxicity Chronic nervous system and hepatic effects 3 Widely used in consumer products Present in biomonitoring, drinking water, indoor environments, surface water, ambient air, soil High reported releases to the environment 3 High environmental persistence Moderate bioaccumulation potential 3 Consumer Industrial No assessment Category



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 27

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

9 N-Nitrosodiethylamine Added 2012 Removed 2014 Probable human

carcinogen 3 Present in biomonitoring, surface water, and ambient air, groundwater, and soil Relatively small reported releases to the environment 2 Moderate environmental persistence Low bioaccumulation potential 2 Industrial No assessment 55-18-5

10 N-Nitrosodimethylamine Added 2012 Removed 2014 Probable human

carcinogen 3 Widely used in consumer products Present in drinking water, surface water, ambient air, groundwater, and soil 3 Moderate environmental persistence Low bioaccumulation potential 2 Consumer Dispersive Industrial No assessment 62-75-9

11 Pentabromophenol Added 2012 Removed 2014 Acute toxicity 3 Used in consumer products Present in surface water and soil 2 High environmental persistence Low bioaccumulation potential 2 Industrial No assessment 608-71-9

12 Polychlorinated naphthalenes Added 2012 Removed 2014 Acute dermal

toxicity Chronic liver effects 1 Widely used in consumer products Present in biomonitoring 3 High environmental persistence High bioaccumulation potential 3 Industrial No assessment Category

13 Quartz (Respirable forms only) Added 2012 Removed 2014 Probable human

carcinogen 3 Widely used in consumer products Present in drinking water Estimated to have high releases to the environment 3 High environmental persistence Low bioaccumulation potential 2 Consumer Industrial No assessment 14808-60-7



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 28

## U.S. Environmental Protection Agency October 2014

Chemical Name When was the chemical added? Hazard Criteria

Met Hazard

Score Exposure Criteria

Met Exposure

Score Persistence &

Bioaccumulation Criteria Met Persistence &

Bioaccumulation Score Use Risk Assessment Status and Other Actions CASRN

14 1,2,4,5- Tetrachlorobenzene Added 2012 Removed 2014 Chronic toxicity 3 Present in ground water and soil 1 Moderate environmental persistence High bioaccumulation potential 3 Industrial No assessment 95-94-3

15 Tris(2,3-dibromopropyl) phosphate (TBP) Added 2012 Removed 2014 Probable human

carcinogen 3 Widely used in consumer products Relatively small reported releases to the environment 0 Moderate environmental persistence Low bioaccumulation potential 2 Consumer No assessment 126-72-7

16 Benzo[a]pyrene Added 2012 Consolidated 2014 Known human

carcinogen 3 Present in biomonitoring, drinking water, indoor environments, surface water, ambient air, groundwater, and soil 2 High environmental persistence Moderate bioaccumulation potential 3 Dispersive Industrial No assessment 50-32-8



### Notes: An asterisk (*) in the Hazard Score column indicates the score is based solely on environmental toxicity. Chemicals in italics were added in 2014. Chemicals in bold have final risk assessments. 

## 29