Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY AND

 POLLUTION PREVENTION

MEMORANDUM

Date: March 10, 2014

SUBJECT: Thiabendazole Acute Probabilistic and Chronic Aggregate Dietary (Food and 

Drinking Water) Exposure and Risk Assessments for Section 3 Registration for 

New Seed Treatment Uses on Assorted Vegetables/Small Grains and Increased 

Seed Treatment Use Rate on Soybean.

PC Code: 060101 DP Barcode: D416470

Decision No.: 476711 Registration No.: 100-889, 100-963

Petition No.: 3F8166 Regulatory Action: Section 3 Registration

Risk Assessment Type: Dietary Case No.: 2760

TXR No.: Not Applicable CAS No.: 148-79-8

MRID No.: Not Applicable 40 CFR: 180.242 and 2010

21 CFR: 556.730

FROM: Bonnie Cropp-Kohlligian, Environmental Scientist

Risk Assessment Branch IV (RABIV), Health Effects Division (HED) (7509P)

THROUGH: Thurston Morton, Chemist, Senior Scientist

RABIV, HED (7509P)

and

Sheila Piper, Chemist, Senior Scientist

David Hrdy, Senior Scientist

Dietary Exposure Science Advisory Council (DESAC), HED (7509P)

TO: Rosemary Kearns/Tony Kish, PM 22

Fungicide Branch, Registration Division (7505P)

Executive Summary

Acute probabilistic and chronic aggregate dietary (food and drinking water) exposure and risk 

assessments were conducted using the Dietary Exposure Evaluation Model software with the 

Food Commodity Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 

food consumption data from the U.S. Department of Agriculture’s (USDA’s) National Health 

and Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA). The 

analyses were conducted in support of a human health risk assessment for the requested increase 
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

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in the currently registered seed treatment use rate on soybeans and the new Section 3 uses of 

thiabendazole for seed treatment on assorted vegetables and small grains including: vegetable, 

root (except sugar beet), subgroup1B; radish tops; onion, bulb, subgroup 3-07A; Brassica, head 

and stem, subgroup 5A; vegetable, cucurbit group 9; alfalfa; spinach; and a number of small 

grains (barley, oats, rye, and triticale). A seed treatment use is already registered for wheat and

tolerances are established for wheat grain and wheat straw but the registrant submitted a new and 

complete dataset for wheat with the current petition. Also, new toxicology data have been 

submitted and an acute dietary endpoint has recently been selected. This memorandum was

reviewed by two peer reviewers of the DESAC and the entire DESAC on 3/6/14, per DESAC 

SOP 2012.1. 

Refined acute probabilistic and chronic dietary exposure and risk assessments were conducted 

for all supported thiabendazole food uses and drinking water. Anticipated residue estimates were 

based on USDA PDP monitoring data for all uses except, cereal grains, citrus oil/peel, dried 

beans/peas, soybeans and the proposed new seed treatment uses. Established/recommended 

tolerances were used for cereal grains (corn tolerance at the method limit of quantitation; 

estimated at 1⁄2 LOQ), citrus oil/peel, dried beans, soybeans and the proposed new seed treatment 

uses. Residues based on field trial data were used for dried peas. Because USDA PDP 

monitoring data did not include benzimidazole (free and conjugated), an additional factor based 

on available metabolism data reflecting foliar use was applied to sweet potato/yam, avocado, 

cantaloupe, strawberry and mushrooms to account for this residue. Anticipated residue estimates 

in meat and milk considered exposure from thiabendazole-treated feedstuffs as well as from the 

use of thiabendazole as an animal drug, regulated by FDA under 21 CFR §556.730 and 21 CFR 

§558.615. The available percent crop treated (%CT or PCT) data for the currently registered 

seed treatment uses of thiabendazole on soybeans and wheat (SLUA report 2/22/13) were used in 

the acute (maximum %CT for both <2.5) and chronic (average %CT for both <1) dietary

assessments. Tier 1 drinking water estimates were used. DEEM default processing factors were 

use for all commodities except potato chips/granules/flakes and wheat processed commodities 

which relied on empirical data demonstrating that residues do not concentration in these 

processed commodities. Also, the maximum theoretical concentration factor for citrus peel 

(3.3x) was applied to orange and lemon peel; since the use on citrus is post harvest and most of 

the residues should be found in/on the peel.

For the probabilistic acute dietary assessment (food and drinking water), the dietary exposure at 

the 99.9th percentile of exposure used 26% of the acute population adjusted dose (aPAD) for the 

general population and 69% of the aPAD for Children 1-2 years, the population subgroup with 

the highest estimated acute dietary exposure. Acute dietary (food and drinking water) exposures 

are below HED’s level of concern (<100% aPAD) for all population subgroups. 

For the chronic dietary assessment, the dietary exposure used 1.1 % of the chronic population 

adjusted dose (cPAD) for the general population and 4.7% of the cPAD for Children 1-2 years 

old, the population subgroup with the highest estimated chronic dietary exposure. Chronic 

dietary (food and drinking water) exposures are below HED’s level of concern (<100% cPAD) 

for all population subgroups. 
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Since thiabendazole is classified as “Likely to be carcinogenic at doses high enough to cause a 

disturbance of the thyroid hormonal balance but not likely to be carcinogenic at doses lower that 

those which could cause a disturbance of this hormonal balance,” a cancer dietary exposure 

assessment is not required.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the 

point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety 

factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in 

more detail are available on the EPA/pesticides web site: “Available Information on Assessing 

Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link: 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-AUG1999).

The most recent dietary risk assessment for thiabendazole was conducted by T. Morton (7/8/10, 

DP Number D379937). That assessment was conducted for aggregate chronic dietary exposure 

(food and drinking water) and risk only. Recently, an acute dietary endpoint for thiabendazole 

has been identified. Details concerning the selected dietary endpoints will be provided in the 

forthcoming risk assessment (D416471).

II. Residue Information

Reference Memos: No DP Barcode, L. Cheng, 2/14/92 (HED Metabolism Committee - Livestock)

D165718, L. Cheng, 1992 Phase V Review (Plant metabolism data (foliar))

D170818/D169697, L. Cheng, 1992 Phase V Review (Livestock metabolism data)

D207850/D214188, S. Mason, 1/8/99 (Residues of concern for post harvest uses)

D261103, T. Morton, 12/2/99 (HED MARC - Plant, Rotational and Water)

D267871, T. Morton, 9/7/00 (HED Residue Chemistry Chapter to RED)

D366219, J. Stokes, 1/13/10 (Most recent livestock diet burden calculations)

D410807/D410833/D313507, S. Hummel, 2/25/14 (Current Petition 3F8166)

Existing/Proposed Agricultural Uses: Thiabendazole is used to control a variety of fruit and 

vegetable diseases such as mold, blight, rot and stains caused by various fungi. It is mostly used 

post harvest as a dip or spray on bananas/plantains, carrot, citrus fruits, pome fruits, potatoes, 

mango, and papaya. It is also registered for use on mushrooms and for use as a seed treatment 

on potato seed pieces, sweet potato seed pieces, soybean, dried beans/peas and wheat. There are 

also tolerances with no U.S. registrations for avocado, cantaloupe and strawberry. [Note: 

Thiabendazole hypophosphorous salt (060102) is not currently registered for food uses.]

Now, Syngenta Crop Protection, Inc. is proposing uses of thiabendazole for seed treatment on: 

vegetable, root (except sugar beet), subgroup1B; radish tops; onion, bulb, subgroup 3-07A; 

Brassica, head and stem, subgroup 5A; vegetable, cucurbit group 9; alfalfa; spinach; and a 
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

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number of small grains (barley, oats, rye, and triticale). They are also requesting an increase in 

the currently registered seed treatment use rate on soybeans.

Residues of Concern: The qualitative nature of the residue in plants is adequately understood 

based on soybean, sugar beet and wheat metabolism studies reflecting foliar treatments. The 

HED Metabolism Assessment Review Committee (MARC) determined that residues of concern 

in plants for regulation and dietary risk assessment include thiabendazole and its metabolite 

benzimidazole (free and conjugated). No residues of 5-hydroxythiabendazole were identified in 

these plant metabolism studies. [Note: The 5-hydroxythiabendazole metabolite was identified 

as a minor residue in rotational crops.] Post harvest treatments are expected to result in the 

highest potential residues of thiabendazole per se in/on plant commodities and potential residues 

of benzimidazole (free and conjugated) are unlikely to contribute significantly to the total 

thiabendazole residues of concern for these uses. Based on re-evaluation of the available foliar

metabolism data, the reviewer has determined that maximum total thiabendazole residues of 

concern in soybean (foliage, immature plant, straw and seed), sugar beet roots, sugar beet tops

and wheat (foliage, forage, straw and grain) may be estimated by multiplying the thiabendazole 

residue level by 1.5x, 1.4x, 1.8x and 1.8x, respectively. 

The qualitative nature of the residue in animals is adequately understood based on acceptable 

ruminant and poultry metabolism studies. The HED Metabolism Committee determined that 

residues of concern in livestock for regulation and dietary risk assessment include thiabendazole, 

5-hydroxythiabendazole (free and conjugated), and benzimidazole.

Currently Established Tolerances: Under 40 CFR §180.242(a)(1) tolerances are established for 

the combined residues of thiabendazole and its metabolite benzimidazole (free and conjugated) 

in/on a number of crops. Tolerances range from 0.01 ppm for seed treatments to 40 ppm in/on 

mushroom. There are also tolerances with no U.S. registrations in/on avocado (10.0 ppm), 

cantaloupe (15.0 ppm) and strawberry (5.0 ppm). Threshold of Regulation (TOR) 

determinations for residues of thiabendazole are established under 40 CFR §180.2010 for use as 

a seed treatment on dry pea (including field pea, pigeon pea, chickpea or lentil); although a 

tolerance level has not been established, residues are not expected to exceed 0.01 ppm (LOQ) 

from the maximum registered application rate of 0.075 lbs ai/100 lbs seed.

Under 40 CFR §180.242(a)(2) tolerances are established for the combined residues of 

thiabendazole and its metabolites 5-hydroxythiabendazole (free and conjugated) and 

benzimidazole in: (1) milk at 0.1 ppm; (2) cattle meat at 0.1 ppm; (3) cattle, goat, horse, and 

sheep meat byproducts at 0.4 ppm; and (4) hog meat byproduct 0.3 ppm. HED has determined 

that there is no reasonable expectation of finite residues of thiabendazole in poultry and egg. 

Existing Animal Drug Uses: Thiabendazole is used medicinally as a chelating agent to bind 

metals. In addition, it is administered to treat several helminthes species such as roundworms in 

livestock and humans. These medicinal uses of thiabendazole are regulated by FDA. This 

dietary risk assessment has considered residues incurred in livestock commodities from the use 

of thiabendazole as an animal drug regulated by FDA.
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Under 21 CFR §556.730 tolerances are established at 0.1 ppm for negligible residues of 

thiabendazole in uncooked edible tissues of cattle, goats, sheep, pheasants and swine, and at 0.05

ppm for negligible residues in milk. These tolerances are established for the prescribed dosing 

and intervals of preslaughter withdrawal and milk discard specified under 21 CFR §558.615. 

New Recommended Tolerances: Under PP#3F8166, Syngenta Crop Protection, Inc. is

petitioning for tolerances for residues of thiabendazole and its metabolite benzimidazole (free 

and conjugated) in/on: vegetable, root (except sugar beet), subgroup1B; onion, bulb, subgroup 

3-07A; Brassica, head and stem, subgroup 5A; vegetable, cucurbit group 9; alfalfa seed; spinach; 

and barley, oats, rye, and triticale grains; and livestock feedstuffs (forage, hay, and straw) of 

alfalfa, barley, oats, rye, wheat and triticale. HED is recommending the tolerances (excluding 

livestock feedstuffs) below for residues of thiabendazole and its metabolite benzimidazole (free 

and conjugated): 

Vegetable, root (except sugar beet), subgroup 1B...........................0.02 ppm

Onion, bulb, subgroup 3-07A ..........................................................0.02 ppm

Brassica, head and stem, subgroup 5-A...........................................0.02 ppm

Vegetable, cucurbit, group 9............................................................0.02 ppm

Spinach.............................................................................................0.02 ppm

Barley, grain.....................................................................................0.05 ppm

Oat, grain..........................................................................................0.05 ppm

Rye, grain.........................................................................................0.05 ppm

Triticale, grain..................................................................................0.05 ppm

HED has determined that it is not appropriate to set a tolerance in/on alfalfa seed and the 

currently established tolerance in/on soybean (0.1 ppm) is adequate for the requested increased 

seed treatment use rate on soybeans. Along with PP#3F8166, Syngenta Crop Protection, Inc.

submitted a new and complete dataset for wheat grain supporting the existing seed treatment use 

on wheat. Although not petitioned-for, HED is recommending that the current tolerance in/on 

wheat grain be lowered from 1.0 ppm (established for foliar uses that no longer exist) to 0.05 

ppm consistent with the new data.

Crop Commodities - Anticipated Residues

Refined acute probabilistic and chronic dietary exposure assessments were conducted for 

thiabendazole using anticipated residue estimates for all existing uses except, cereal grains, citrus

oil/peel, dried beans/peas and soybeans. Established/recommended tolerances were used for 

cereal grains (corn tolerance at the method limit of quantitation; estimated at 1⁄2 LOQ), citrus 

oil/peel, dried beans, soybeans and the proposed new seed treatment uses. Maximum residues 

based on field trial data were used for dried peas. Anticipated residue estimates for carrot, 

potato, sweet potato, cantaloupe, orange, apple, pear baby food, strawberry, mushrooms, 

avocado, banana, mango, and papaya were based on USDA PDP monitoring data for 

thiabendazole and translated, as appropriate to yams, other citrus fruits, other pome fruits and 

plantains. Because USDA PDP monitoring data did not include benzimidazole (free and 

conjugated), an additional factor based on available metabolism data reflecting foliar use was 

applied to sweet potato/yam, avocado, cantaloupe, strawberry and mushrooms to account for this 

residue. The factor (1.4x) applied to sweet potato/yam was based on sugar beet root metabolism 
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data and the factor (1.8x) applied to avocado, cantaloupe, strawberry and mushrooms was based 

on the maximum factor identified in any of the metabolism studies. See Attachment 1 for 

details.

USDA PDP findings for the metabolite 5-hydroxythiabendazole: The HED MARC determined 

that residues of concern in plants for regulation and dietary risk assessment include 

thiabendazole and its metabolite benzimidazole (free and conjugated). No residues of 5-

hydroxythiabendazole were identified in the plant metabolism studies reflecting foliar use and it 

was not identified as a significant residue in the rotational crops studies. Hence, based on 

available residue chemistry data, 5-hydroxythiabendazole was not deemed a significant residue 

in crops. 

USDA PDP did generate some limited data for 5-hydroxythiabendazole (assumed to be free 

only) because it was easily determined by the data-collection methods (personal communication 

with D. Hrdy). For some of the USDA PDP data used in the dietary assessments, HED found 

that detectable residues of 5-hydroxythiabendazole were also detectable in/on some of the apple, 

apple juice, apple sauce, banana, orange, orange juice and potato samples used in the dietary

assessments. However, detailed analyses of the individual sample data (personal communication 

with S. Nako) found that these detectable levels of 5-hydroxythiabendazole did not rise to a level 

of significance as a percentage of the levels of the parent present (<10%) for all but orange juice; 

and in the case of orange juice, the levels detected were extremely low (≤ 0.002 ppm) and nearly

equal to the LOD of the data-collection method (0.001 ppm) for 5-hydroxythiabendazole in/on 

orange juice. See Table 1 below for details. Hence, these detectable levels of 5-

hydroxythiabendazole are of little consequence to the dietary risk assessments and were not 

included. Thus far, analyses of all of the available USDA PDP 5-hydroxythiabendazole data (up 

through 2012 and with respect to levels in the absolute and/or as a percent of the residues of 

parent) do not seem to contradict the HED MARC decision that residues of 5-

hydroxythiabendazole are not a residue of concern in/on crops.

Table 1. USDA PDP Data for Detectable Residues of Free 5-Hydroxythiabendazole (5-Hydroxy).

1

Commodities with 

Detects/Years with Detects and 

used in Dietary Assessments

Detects Found (Number of samples or ppm) Percent Detects 

Relative to Parent

(%)

Samples with

5-Hydroxy and Parent

Detected/Total Used in

Dietary Assessment1

Samples

with Only

5-Hydroxy

Detected

Maximum

5-Hydroxy

Detected

(ppm) mean max

Apple/2009 10/1162 0 0.018 1.0 1.8

Apple Juice/2007 and 2008 14/183 0 0.0043 1.6 2.4

Apple Sauce/2006 39/744 1 0.019 2.7 8.3

Banana/2006 an d 2007 60/2045 0 0.002 7.5 24

Orange/2009 2/1488 0 0.005 3.4 3.8

Orange Juice/2006 8/1106 0 0.002 24 30

Potato/2008 and 2009 6/1488 0 0.017 1.1 3.0

1

 Not all samples used in the dietary analyses were analyzed for residues of 5-hydroxythiabendazole. This table 

only includes data for samples used in the current dietary risk assessments which were found to have detectable 

residues of thiabendazole and 5-hydroxythiabendazole. These data were extracted from a more complete analysis of 

the available USDA PDP 5-hydroxythiabendazole data conducted by S. Nako.
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Livestock Commodities - Anticipated Residues

Under 40 CFR §180.242(a)(2) tolerances are established for the combined residues of 

thiabendazole and its metabolites 5-hydroxythiabendazole (free and conjugated) and 

benzimidazole in: (1) milk at 0.1 ppm; (2) cattle meat at 0.1 ppm; (3) cattle, goat, horse, and 

sheep meat byproducts at 0.4 ppm; and (4) hog meat byproduct 0.3 ppm. HED has determined 

that there is no reasonable expectation of finite residues of thiabendazole in poultry and egg. In 

the most recent evaluation of maximum reasonably balanced dietary burdens for ruminants and 

available ruminant livestock metabolism and magnitude of the residue data, HED found that 

some of the established livestock tolerances could be lowered but did not recommend this action. 

Livestock feedstuffs in the current petition are not expected to increase the most recent 

maximum reasonably balanced dietary burden estimates. 

The maximum reasonably balanced dietary burdens for beef and dairy cattle are 21 ppm and 9.2 

ppm, respectively. In the ruminant feeding study (MRID 40271707), thiabendazole was fed to 

dairy cows (3 animals/dose group) at levels of 25, 75, and 250 ppm in the diet for 28 consecutive 

days. These feeding levels are equivalent to 1.2x, 3.6x, and 12x the dietary burden for beef cattle 

(21.0 ppm) and 2.7x, 8.2x, and 27x the dietary burden for dairy cattle (9.2 ppm). Residues of 

thiabendazole and 5-hydroxythiabendazole (free and conjugated) were determined in fat, kidney, 

liver and muscle within 24 hours of the last dose (day 29) and after a depuration period of nearly 

30 days (day 57). Residues of thiabendazole and 5-hydroxythiabendazole (free and conjugated) 

were determined in milk on days 1, 2, 4, 7, 14, 21 and 28 of the dosing period and on days 29, 

35, 42, 49 and 56 of the depuration period. 

Although residues of benzimidazole were not determined in the feeding study, based on the goat 

metabolism study, finite residues of benzimidazole are not expected in milk and should not be 

greater than 0.7x the level of 5-hydroxythiabendazole residues found in tissues. The metabolite, 

5-hydroxythiabendazole was the major residue in kidney, liver and milk; it was an order of 

magnitude or more than parent. Maximum combined residues of thiabendazole, 5-

hydroxythiabendazole (free and conjugated) and benzimidazole from exposure to thiabendazoletreated feedstuffs in fat, kidney, liver, meat and milk are estimated at 0.005 ppm, 0.2 ppm, 0.07

ppm, 0.001 ppm and 0.017 ppm, respectively. See Table 2 below for details and calculations.

Table 2. Maximum residues of thiabendazole (TBZ), 5-hydroxythiabendazole (5-OH-TBZ) and 

benzimidazole (BNZ) based on days 2-28 of the cattle feeding study (MRID 40271707).

Matrix

Feeding 

Level

(ppm) 1

TBZ

Found

(ppm) 

5-OH-TBZ

Found

(ppm) 

BNZ

Estimated

(ppm) 2

Combined Residues (ppm)

Sum of 

residues 

found

Adjusted 

for 

residues in 

control3

Adjusted to 

1x feeding 

level

Fat 0 0.017 0.002 0.001 0.020 -- --

25 0.018 0.004 0.003 0.025 0.005 0.004

75 0.017 0.012 0.008 0.037 0.017 0.005

250 0.015 0.010 0.007 0.032 0.012 0.001

Kidney 0 0.018 0.009 0.006 0.033 -- --

25 0.012 0.049 0.034 0.095 0.062 0.05

75 0.017 0.421 0.295 0.733 0.700 0.2

250 0.030 0.546 0.382 0.958 0.925 0.08
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Liver 0 0.016 0.012 0.008 0.036 -- --

25 0.022 0.028 0.020 0.070 0.034 0.03

75 0.060 0.130 0.091 0.281 0.245 0.07

250 0.080 0.156 0.109 0.185 0.149 0.01

Muscle 0 0.015 0.003 0.002 0.020 -- --

25 0.014 0.003 0.002 0.019 <0.001 <0.001

75 0.014 0.006 0.004 0.024 0.004 0.001

250 0.017 0.005 0.004 0.026 0.006 <0.001

Milk 4 0 0.019 0.005 zero 0.024 -- --

25 0.018 0.018 0.036 0.012 0.004

75 0.014 0.148 0.162 0.138 0.017

250 0.016 0.246 0.262 0.238 0.009

1 The 25, 75, and 250 ppm dose levels are equivalent to 1.2x, 3.6x, and 12x the maximum reasonably balanced 

dietary burden of beef cattle (21 ppm) and 2.7x, 8.2x, and 27x the maximum reasonably balanced dietary 

burden of dairy cattle (9.2 ppm), respectively.

2 Residues of benzimidazole were not determined in the cattle feeding study so estimates of benzimidazole are 

based on the goat metabolism study. Based on these data benzimidazole residues would not exceed 0.7x the 

residues of 5-hydroxythiabendazole (free and conjugated) found in tissues. Residues of benzimidazole were 

not detected in milk from the goat metabolism study. 

3 Combined Residues in treated samples are adjusted for Combined Residues in control samples. Source of 

residues in control samples was not specified in the submission but is likely a consequence of the data collection 

method which used fluorometry detection.

4 Residue data are from milk samples collected on days 2-28 of dosing period. Residues in milk plateau around 

day 4 of the dosing period. Residues of 5-hydroxythiabendazole were an order of magnitude greater than parent 

at the higher doses.

In the depuration study, residues of thiabendazole and 5-hydroxythiabendazole in samples of 

tissues and milk from all dosing levels were nearly equal to residues in the control samples after 

a depuration period of about 30 days (day 57) and 4 days (first depuration day tested for milk 

samples), respectively.

Thiabendazole is also registered as an animal drug by FDA and under 21 CFR §558.615 it is 

prescribed for use in feeds of cattle (max. 5 g/100 lb body weight), goats (max. 3 g/100 lb body

weight), sheep (max. 2 g/100 lb body weight), swine (max. 0.1 % in feed continuously for 2 

weeks followed by 0.02 % in feed for 8-14 weeks) and peasants (max. 0.05 % in feed 

continuously for 2 weeks). Lengthy preslaughter withdrawal intervals (21-30 days) are imposed 

for all but cattle (3 days). Also, there is a significant milk discard interval (4 days; within 96 

hours (8 milkings)). Related tolerances are established under 21 CFR §556.730 at 0.1 ppm for 

negligible residues of thiabendazole in uncooked edible tissues of cattle, goats, sheep, swine and 

pheasants, and at 0.05 ppm for negligible residues in milk. A tolerance for negligible residues is 

required when it is not possible to determine whether finite residues will be incurred but there is 

reasonable expectation that they may be present (21 CFR §556.1(a)(2)). Hence, it can be 

assumed that these tolerances are established at a limit of quantitation and residues for 

thiabendazole used as an animal drug can be estimated at 1⁄2LOQ. Therefore, residues of 

thiabendazole from the use as an animal drug should not be greater than 0.05 ppm and 0.025 

ppm (1⁄2LOQ) in treated livestock tissues and milk, respectively. Moreover, given the lengthy

prescribed preslaughter withdrawal intervals for all but cattle, it would be reasonable to estimate 

anticipated residues of thiabendazole in the edible tissues of goats, sheep, swine and pheasants 

for the purposes of dietary risk assessment at nil. The available feeding/depuration study data 

indicate that residues do not plateau in milk for 3-4 days and decline relatively rapidly once 
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dosing is terminated; hence the single dose and prescribed milk discard interval (4 days) should 

ensure that residues in milk should be extremely low.

There are extensive USDA PDP data available for milk (2004-2005) which found no detectable 

residues of thiabendazole (<0.001 ppm) in 1485 samples and for heavy cream (2007) which 

found no detectable residues of thiabendazole (<0.008 ppm) or 5-hydroxythiabendazole (<0.025 

ppm) in 742 samples. [Note: Heavy cream samples from 2005 and all milk samples were not 

analyzed for residues of 5-hydroxythiabendazole.] Milk samples were not analyzed of residues 

of 5-hydroxythiabendazole; however, based on the cattle feeding study, residues of 5-

hydroxythiabendazole (free and conjugated) could be estimated at an order of magnitude greater 

that parent. Hence, the estimated combined residues of parent and 5-hydroxythiabendazole (free 

and conjugated) in milk would be < 0.01 ppm.

Conclusions: Under 40 CFR §180.242(a)(2) tolerances are established for the combined 

residues of thiabendazole and its metabolites 5-hydroxythiabendazole (free and conjugated) and 

benzimidazole in: (1) milk at 0.1 ppm; (2) cattle meat at 0.1 ppm; (3) cattle, goat, horse, and 

sheep meat byproducts at 0.4 ppm; and (4) hog meat byproduct 0.3 ppm. HED has determined 

that there is no reasonable expectation of finite residues of thiabendazole in poultry and egg. 

Based on available livestock feeding study data, maximum thiabendazole residues of concern 

resulting from exposure to thiabendazole-treated feedstuffs are estimated at 0.005 ppm in fat, 0.2 

ppm in kidney, 0.07 ppm in liver and 0.001 ppm in meat. The estimate in kidney (0.2 ppm) will 

be translated to meat-byproducts. These estimates will also cover anticipated residues of 

thiabendazole in tissues from the use of thiabendazole as an animal drug with the exceptions of 

beef meat and beef fat.

Thiabendazole is also used as an animal drug, regulated by FDA, and tolerances are established 

under 21 CFR §556.730 for residues of thiabendazole at 0.1 ppm for negligible residues of 

thiabendazole in uncooked edible tissues of cattle, goats, sheep, pheasants and swine, and at 0.05

ppm for negligible residues in milk. However, given the lengthy prescribed preslaughter 

withdrawal intervals (21-30 days) for all but cattle (3 days), it would be reasonable to estimate 

residues of thiabendazole in the edible tissues of goats, sheep, swine and pheasants for the 

purposes of dietary risk assessment at nil. Therefore, residues of thiabendazole are estimated at 

0.05 ppm (1⁄2LOQ) in beef meat and beef fat. [Note: Available feeding and metabolism data 

indicate that parent is the major residue in meat and fat.] These estimates will also cover 

anticipated residues of thiabendazole in these tissues from exposure to thiabendazole-treated 

feedstuffs.

There are extensive USDA PDP data available for milk (2004-2005) which found no detectable 

residues of thiabendazole (<0.001 ppm) in 1485 samples and for heavy cream (2007) which 

found no detectable residues of thiabendazole (<0.008 ppm) or 5-hydroxythiabendazole (<0.025 

ppm) in 742 samples. [Note: Heavy cream samples from 2005 and all milk samples were not 

analyzed for residues of 5-hydroxythiabendazole.] Milk samples were not analyzed of residues 

of 5-hydroxythiabendazole; however, based on the cattle feeding study, residues of 5-

hydroxythiabendazole (free and conjugated) could be estimated at an order of magnitude greater 

that parent. Hence, the estimated combined residues of parent and 5-hydroxythiabendazole (free 
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 10 of 47

and conjugated) in milk would be < 0.01 ppm. Based on the available metabolism data, residues 

of benzimidazole are not expected in milk.

Fish

No tolerances are currently established for residues of thiabendazole in fish. The USDA 

Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 2009, and 2010. 

Only the catfish samples collected in 2008 (552 samples) were analyzed for residues of 

thiabendazole and only one was found to have detectable residues of thiabendazole (0.0031 ppm) 

at a level very close to the limit of detection (0.002 ppm). As a result, residues in fish were not 

included in the assessment.

III. Percent Crop Treated Information

The available percent crop treated (%CT or PCT) data for the currently registered seed treatment 

uses of thiabendazole on soybeans and wheat (SLUA report 2/22/13) were used in the acute and 

chronic dietary assessments. The following maximum percent crop treated estimates were used 

in the acute dietary risk assessment for the following crops that are currently registered for 

thiabendazole: soybeans 2.5% and wheat 2.5%. The following average percent crop treated 

estimates were used in the chronic dietary risk assessment for the following crops that are 

currently registered for thiabendazole: soybeans 1% and wheat 1%. The available %CT data for 

the currently registered seed treatment use of thiabendazole on potatoes was not use since there 

is also a post harvest use on potatoes. No other %CT data are available according to BEAD 

(Email dated 12/12/13 from S. Haddad (BEAD) to T. Morton (HED)) and, therefore, 100% crop 

treated was assumed for all other existing/proposed uses. See Attachment 9.

IV. Drinking Water Data -

EFED Memo: D410805, 2/24/14, J. Wolf. (Drinking Water Assessment (DWA))

The drinking water estimates used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED; D410805). EFED conducted a Tier I drinking 

water assessment for thiabendazole in surface water using the FQPA Index Reservoir Screening 

Tool (FIRST) model and in ground water using the Pesticide Root Zone Model for GroundWater 

(PRZM-GW). The highest Estimated Drinking Water Concentrations (EDWCs) resulted from 

the currently registered use of thiabendazole on wheat as a seed treatment and not from the 

proposed new uses or requested soybean use rate increase. Surface water estimates were higher

than ground water estimates. The highest EDWCs for peak and annual mean were 3.80 and 0.47 

μg/L (ppb), respectively. The peak concentration of 0.0038 ppm and annual mean of 0.00047 

ppm were used in the acute and chronic dietary exposure analyses, respectively. See Table 3 

below for details.

Table 3. Summary of Tier 1 Estimated Drinking Water Concentrations in Surface and Ground Water for 

the New Uses and Previously Assessed Wheat Use.

New Uses and Reassessment Thiabendazole

Peak Concentration Annual Average

Surface Water Crop (app rate lb a.i./A) Model μg/L

New Uses (0.15) FIRST 2.85 0.35

Wheat (0.20) FIRST 3.80 0.47
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

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From RED Peak Concentration 56-day Average

Wheat (0.20) GENEEC 2.4011.551

Groundwater Highest Daily 

Concentration

Average 

Concentration after 

Breakthrough

New Uses (0.15) PRZM-GW 0.46 -

Wheat (0.20) PRZM-GW 0.62 -

1

 The highest EDWCs in surface water for thiabendazole were previously prepared for the 2002 Reregistration 

Eligibility Decision (RED), using the Tier 1 GENEEC model (which has since been replaced by the FIRST model) 

for surface water and the SCI-GROW model (which has since been replaced with PRZM-GW) for groundwater. 

The peak concentrations are higher than previously determined for the RED primarily due to changes in the 

conceptual model (GENEEC vs. FIRST) (e.g., differences of field size and shape and the implementation of the 

Index Reservoir) and difference in fate input values for modeling. The chronic EDWCs are lower than before due 

the inclusion of the Index Reservoir (e.g., size and flow through the reservoir).

The drinking water models and their descriptions are available at the EPA internet site: 

http://www.epa.gov/oppefed1/models/water/.

V. DEEM-FCID Program and Consumption Information

Thiabendazole acute probabilistic and chronic dietary exposure assessments were conducted 

using the DEEM-FCID, Version 3.16, which incorporates 2003-2008 consumption data from 

USDA’s NHANES/WWEIA. The data are based on the reported consumption of more than 

20,000 individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) 

are linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; 

baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation 

files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption 

data are averaged for the entire U.S. population and within population subgroups. However, for 

acute exposure assessment, consumption data are retained as individual consumption events. 

Based on analysis of the 2003-2008 WWEIA consumption data, which took into account dietary

patterns and survey respondents, HED concluded that it is most appropriate to report risk for the 

following population subgroups: the general U.S. population, all infants (<1 year old), children 

1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99

years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup.

For an acute exposure assessment, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

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and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating 

relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for analyses performed at all levels of refinement. However, for 

deterministic assessments, any significant differences in user vs. per capita exposure and risk are 

specifically identified and noted in the risk assessment.

VI. Toxicological Information

The doses and toxicological endpoints selected for dietary risk assessment are summarized in

Table 4 below. Since the most recent dietary assessment, an acute dietary endpoint has been 

selected. For details on the selected dietary endpoints, see the forthcoming risk assessment 

(D416471).

Table 4. Summary of Toxicological Doses and Endpoints for Thiabendazole

Exposure/

Scenario

Point of 

Departure

Uncertainty/FQ

PA Factors

Level of Concern for 

Risk Assessment Study and Toxicological Effects

Acute Dietary

(general population 

including females 13 

– 49 years and 

children)

NOAEL =

50 mg/kg/day

UFA = 10x

UFH = 10x

FQPA = UFDB = 

10x

aRfD =

0.05 mg/kg/day

aPAD =

0.05 mg/kg/day

Acute neurotoxicity Study MRID 48996309

LOAEL = 200 mg/kg based decreases in the FOB (reduced 

body temperature in males p<0.05, and reduced rearing in 

females ↓54%, p<0.01), reduced locomotor activity in males 

and females (↓37-46%, p<0.01), at time of peak effect 

(approximately 3 hours post-dose). Reduced body weight gain 

(p<0.01) and food consumption (↓44%, p<0.01) occurred on 

day 1.

Chronic Dietary NOAEL =

10mg/kg/day

UFA = 3x

UFH = 10x

FQPA = UFDB = 

10x

cRfD =

0.033 mg/kg/day

cPAD =

0.033 mg/kg/day

2-Year chronic carcinogenicity in the Rat MRID 43593201

co-critical with subchronic toxicity rat study MRID 

42942802

Chronic LOAEL = 30 mg/kg/day based on decreased body 

weight gains and liver hypertrophy. Thiabendazole induced 

thyroid adenomas in male rats at dosages of ≥30 mg/kg/day.

Subchronic LOAEL = 40 mg/kg/ based on reduced body 

weight and body weight gains ((↓11%) and histopathological 

changes in the bone marrow (erythroid hyperplasia), liver 

(centrilobular hypertrophy), thyroid (follicular cell 

hypertrophy) and spleen (pigmented).

Cancer (all routes) Likely to be carcinogenic at doses high enough to cause a disturbance of the thyroid hormonal balance but not likely to be 

carcinogenic at doses lower that those which could cause a disturbance of this hormonal balance (TXR 0050554).

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and used to mark the beginning of 

extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = 

lowest observed adverse effect level. UF = uncertainty factor. UFA = extrapolation from animal to human (interspecies). UFH = potential variation in 

sensitivity among members of the human population (intraspecies). UFDB = to account for the absence of key date (i.e., lack of a critical study). FQPA SF 

= FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose. MOE = margin of exposure. LOC = level of 

concern.

DAF = dermal absorption factor (TXR 0055373)

VII. Results/Discussion 

For acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the 

PAD. The DEEM-FCID analyses estimate the dietary exposure of the U.S. population and 

various population subgroups. The acute and chronic results reported in Table 4 are for the 

general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 

13-19, females 13-49, adults 20-49, and adults 50+ years. 
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

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Estimated acute and chronic dietary exposures to thiabendazole from food and drinking water are

below HED’s level of concern for all population subgroups. The combined acute dietary

exposure from food and drinking water at the 99.9th percentile of exposure is estimated at

0.012953 mg/kg/day for the general population, equivalent to 26% of the aPAD. The population 

subgroup with the highest estimated acute dietary exposure is children 1-2 years, with an 

estimated exposure at the 99.9th percentile of 0.034322 mg/kg/day, equivalent to 69% of the 

aPAD. The combined chronic dietary exposure from food and drinking water is estimated at 

0.000379 mg/kg/day for the general population (1.1% of the cPAD) and 0.001562 mg/kg/day the 

most highly exposed population subgroup, Children 1-2 years old (4.7% cPAD). The results for 

all populations are summarized in Table 5 below. 

Since thiabendazole is classified as “Likely to be carcinogenic at doses high enough to cause a 

disturbance of the thyroid hormonal balance but not likely to be carcinogenic at doses lower that 

those which could cause a disturbance of this hormonal balance,” a cancer dietary exposure 

assessment is not required.

Table 5. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Thiabendazole.

Population Subgroup

Acute Dietary

(99.9 Percentile) Chronic Dietary Cancer

Dietary 

Exposure 

(mg/kg/day)

% aPAD*

Dietary 

Exposure

(mg/kg/day)

% cPAD*

Dietary 

Exposure

(mg/kg/day)

Risk

General U.S. Population 0.012953 26 0.000379 1.1

All Infants (<1 year old) 0.021098 42 0.000612 1.9

N/A N/A

Children 1-2 years old* 0.034322 69 0.001562 4.7

Children 3-5 years old 0.028211 56 0.001081 3.3

Children 6-12 years old 0.017865 36 0.000597 1.8

Youth 13-19 years old 0.009042 18 0.000295 0.9

Adults 20-49 years old 0.007528 15 0.000267 0.8

Adults 50-99 years old 0.007786 16 0.000276 0.8

Females 13-49 years old 0.007789 16 0.000256 0.8

*The population subgroup(s) with the highest risk estimates.

VIII. Characterization of Inputs/Outputs

With regards to food, refined acute probabilistic and chronic dietary exposure assessments were 

conducted for thiabendazole using anticipated residue estimates for all existing uses except, 

cereal grains, citrus oil/peel, dried beans/peas and soybeans. Established/recommended 

tolerances were used for cereal grains (corn tolerance at the method limit of quantitation; 

estimated at 1⁄2 LOQ), citrus oil/peel, dried beans, soybeans and the proposed new seed treatment 

uses. Maximum residues based on field trial data were used for dried peas. Anticipated residue

estimates for carrot, potato, sweet potato, cantaloupe, orange, apple, pear baby food, strawberry, 

mushrooms, avocado, banana, mango, and papaya were based on USDA PDP monitoring data 

for thiabendazole and translated, as appropriate to yams, other citrus fruits, other pome fruits and 

plantains. Because USDA PDP monitoring data did not include benzimidazole (free and 

conjugated), an additional factor based on available metabolism data reflecting foliar use was 
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

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applied to sweet potato/yam, avocado, cantaloupe, strawberry and mushrooms to account for this 

residue.

There is no reasonable expectation of finite residues of thiabendazole in poultry and eggs. 

Anticipated residue estimates in meat and milk considered exposure from thiabendazole-treated 

feedstuffs as well as from the use of thiabendazole as an animal drug, regulated by FDA. 

Anticipated residue estimates in tissues with the exceptions of beef meat and beef fat were based 

on feeding study data. Anticipated residue estimates in the meat and fat of beef were based on 

tolerances established under 21 CFR §556.730 for residues of thiabendazole at 0.1 ppm for 

negligible residues of thiabendazole in tissues. The anticipated residue estimate in milk was 

based on USDA PDP data for parent and available feeding study data for its metabolite, 5-

hydroxythiabendazole (free and conjugated). All estimates were supported by available 

ruminant metabolism data.

DEEM default processing factors were use for all commodities except potato 

chips/granules/flakes and wheat processed commodities which relied on empirical data

demonstrating that residues do not concentration in these processed commodities. Also, the 

maximum theoretical concentration factor for citrus peel (3.3x) was applied to orange and lemon 

peel, since the use on citrus is post harvest and most of the residues should be found in/on the 

peel.

The available percent crop treated (%CT or PCT) data for the currently registered seed treatment 

uses of thiabendazole on soybeans and wheat (SLUA report 2/22/13) were used in the acute 

(maximum %CT for both <2.5) and chronic (average %CT for both <1) dietary assessments. The 

available %CT data for the currently registered seed treatment use of thiabendazole on potatoes 

was not use since there is also a post harvest use on potatoes. No other %CT data are available 

according to BEAD (Email dated 12/12/13 from S. Haddad (BEAD) to T. Morton (HED)) and, 

therefore, 100% crop treated was assumed for all other existing/proposed uses.

The drinking water estimates used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED; D410805). EFED conducted a Tier I drinking 

water assessment for thiabendazole in surface water using the FQPA Index Reservoir Screening 

Tool (FIRST) model and in ground water using the Pesticide Root Zone Model for GroundWater 

(PRZM-GW). The highest Estimated Drinking Water Concentrations (EDWCs) resulted from 

the currently registered use of thiabendazole on wheat as a seed treatment and not from the 

proposed new uses or requested soybean use rate increase. Surface water estimates were higher

than ground water estimates. The highest EDWCs were 3.80 and 0.47 μg/L (ppb) for peak and 

annual mean, respectively. The peak concentration of 0.0038 ppm and annual mean of 0.00047 

ppm were used in the acute and chronic dietary exposure analyses, respectively.

Estimated acute dietary exposures to thiabendazole from food and drinking water are below 

HED’s level of concern for all population subgroups. The combined acute dietary exposure from 

food and drinking water at the 99.9th percentile of exposure is estimated to 0.012953 mg/kg/day

for the general population, equivalent to 26% of the aPAD. The population subgroup with the 

highest estimated acute dietary exposure is children 1-2 years, with an estimated exposure at the 

99.9th percentile of 0.034322 mg/kg/day, equivalent to 69% of the aPAD. The major risk drivers 
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

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were fresh apple with peel (58%), fresh pear (14%) and apple juice (9%) for the most highly 

exposed population subgroup (Children 1-2 years). Anticipated residue estimates for these food 

forms were based on available USDA PDP data. Available apple and apple juice data were used 

directly and apple data were translated to pear. [Note: For pears, the reviewer used the more 

recent USDA PDP data for apple (2009 and 2010) rather than the older USDA PDP data for pear 

(2003-2005). USDA PDP data for pear in 2009 and 2010 did not analyze for residues of 

thiabendazole.] USDA PDP findings for these food forms were relatively high with regards to 

both level and frequency most likely due to the post harvest use on these crops. The analyses 

assumed 100% crop treated in the absence of more specific data. Tier 1 drinking water estimates

were used; however, drinking water did not contribute significantly to the dietary exposure for 

any of the population subgroups. [See Attachment 5 for acute results for food only.] Additional 

percent crop treated data and/or further refinements to the drinking water estimates might be of 

little value to further refinements of the acute dietary assessments.

Chronic dietary exposure estimates for food and drinking water are well below HED’s level of 

concern (<100% CPAD) for all population subgroups. The dietary exposure is estimated at 

0.000379 mg/kg/day for the general population (1.1% of the cPAD) and 0.001562 mg/kg/day

(4.7% of the cPAD) for Children 1-2 years old, the population subgroup with the highest 

estimated chronic dietary exposure. 

IX. Conclusions

Refined acute probabilistic and chronic dietary exposures were conducted for all supported 

thiabendazole food uses and drinking water. For the acute assessment, aggregate dietary (food 

and drinking water) exposures are below HED’s level of concern (<100% aPAD) at the 99.9th

percentile of exposure for all population subgroups. The combined acute dietary exposure from 

food and drinking water at the 99.9th percentile of exposure is estimated to 0.012953 mg/kg/day

for the overall U.S. population, equivalent to 26% of the aPAD. The population subgroup with 

the highest estimated acute dietary exposure is children 1-2 years, with an estimated exposure at 

the 99.9th percentile of 0.034322 mg/kg/day, equivalent to 69% of the aPAD. 

Chronic dietary exposure estimates for food and drinking water are well below HED’s level of 

concern (<100% CPAD) for all population subgroups. The dietary exposure is estimated at 

0.000379 mg/kg/day for the general U.S. population (1.1% of the cPAD) and 0.001562

mg/kg/day (4.7% of the cPAD) for Children 1-2 years old, the population subgroup with the 

highest estimated chronic dietary exposure. 

X. List of Attachments

• Attachment 1. Data and Residue Estimates Used in the Dietary Exposure Analyses

• Attachment 2. Residue Distribution Files for Acute Analysis

• Attachment 3. Acute Residue Input file

• Attachment 4. Acute Results - Food and Drinking Water

• Attachment 5. Acute Results - Food only

• Attachment 6. CEC for Most Highly Exposed Population Subgroup (Children 1-2 years)
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• Attachment 7. Chronic Residue Input file

• Attachment 8. Chronic Results File

• Attachment 9. Screening Level Usage Analysis (SLUA) for Thiabendazole (060101)
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

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Attachment 1. Data and Residue Estimates Used in the Dietary Exposure Analyses

Table 1. Data and Residue Estimates Used in the Dietary Exposure Analyses.

RAC Food

Forms

Blending

Classification1

Data

Source2

Number

of

Samples

Detectable Residues Non-Detectable

Residues

%CT3 Processing

Factors4

Anticipated Residue 

Estimates/Tolerance5

Factor

for 

Metabolite6

Number

[Percent]

Max

(ppm)

Average

(ppm) Number

Max.

LOD/LOQ

(ppm)

Acute Chronic

Members of Root and Tuber Vegetables (Crop Group 1)7

Carrot root PB or 

NB

PDP

2007

2006

1488 6

[<1%]

0.00480.002567 1482 0.03

100

DEEM 

default

RDF#5 PDP Average

0.0149 ppm9

None. Post 

harvest Use.

baby food PB or 

NB

PDP

2012

792 0 -- -- 792 0.004 PDP Maximum/Average

0.002 ppm (1⁄2LOD)

juice PB or 

NB

Translate PDP Carrot Root Data RDF#5 PDP Average

0.0149 ppm9

Potato tuber PB or 

NB

PDP

2009

2008

1488 114

[8%]

1.5 0.195919 1374 0.03 DEEM 

default

RDF#7 PDP Average

0.0289 ppm9

None. Post 

harvest Use.

chips B Translate PDP Potato Tuber Data 1.010 PDP Average 0.0289 ppm9

granules/

flakes

B

flour B DEEM 

default

Sweet Potato tuber PB or 

NB

PDP

2010

2009

2008

1476 8

[<1%]

0.014 0.006125 1468 0.01 DEEM 

default

RDF#12 PDP Average

0.005 ppm9

1.4x

baby food PB or 

NB

PDP

2011

2010

776 0 -- -- 776 0.003 PDP Maximum/Average

0.0015 ppm (1⁄2LOD)

Yam tuber NB Translate PDP Sweet Potato Tuber Data RDF#12 PDP Average

0.0050 ppm9

Vegetables, 

root (except 

sugar beet), 

subgroup 1B

root/tuber PB or 

NB

Tolerance Not Applicable (N/A) Tolerance 0.02 ppm None.

Ginseng dried B
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Table 1. Data and Residue Estimates Used in the Dietary Exposure Analyses.

RAC Food

Forms

Blending

Classification1

Data

Source2

Number

of

Samples

Detectable Residues Non-Detectable

Residues

%CT3 Processing

Factors4

Anticipated Residue 

Estimates/Tolerance5

Factor

for 

Metabolite6

Number

[Percent]

Max

(ppm)

Average

(ppm) Number

Max.

LOD/LOQ

(ppm)

Acute Chronic

Members of Bulb Vegetable (Crop Group 3)

Onion, bulb, 

subgroup 3-

07A

bulb NB Tolerance Not Applicable (N/A) 100 DEEM 

default

Tolerance 0.02 ppm None.

dried B

Members of Leafy Vegetables (except Brassica Vegetables) (Crop Group 4)

Spinach vegetable PB or 

NB

Tolerance Not Applicable (N/A) 100 DEEM 

default

Tolerance 0.02 ppm None.

Members of Brassica (Cole) Leafy Vegetables (Crop Group 5)

Head and 

Stem, 

subgroup 5-A

vegetable PB or 

NB

Tolerance Not Applicable (N/A) 100 DEEM 

default

Tolerance 0.02 ppm None.

Members of Legume Vegetables (Crop Group 6)

Soybean seed B Tolerance Not Applicable (N/A) max. 

2.5

ave. 1 

DEEM

default

Tolerance 0.1 ppm None.

milk

flour

oil

Dried beans seed 100

Chickpea flour

Dried peas seed FT

45428201

Not Applicable (N/A) Threshold of Regulation 

(TOR) decision 

(PP#1E6323; D343139, D. 

Davis, 8/29/07). No 

tolerance established under 

180.2010. Maximum 

residues in/on seed 

estimated at 0.01 ppm

(LOQ); Used 0.005 ppm 

(1⁄2LOQ)

None. 

Estimate 

includes all 

residues of 

concern.

Members of Cucurbit Vegetables (Crop Group 9)

Cantaloupe11 fruit PB or 

NB

PDP

2012

2011

2010

1482 5

[<1%]

0.12 0.0662 1477 0.01 100 DEEM 

default

RDF#4 PDP Average

0.0052 ppm9

1.8x

All Others Tolerance Not Applicable (N/A) Tolerance 0.02 ppm None.

Pumpkin seed B
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Table 1. Data and Residue Estimates Used in the Dietary Exposure Analyses.

RAC Food

Forms

Blending

Classification1

Data

Source2

Number

of

Samples

Detectable Residues Non-Detectable

Residues

%CT3 Processing

Factors4

Anticipated Residue 

Estimates/Tolerance5

Factor

for 

Metabolite6

Number

[Percent]

Max

(ppm)

Average

(ppm) Number

Max.

LOD/LOQ

(ppm)

Acute Chronic

Citrus Fruits (Crop Group 10)

Orange fruit PB or 

NB

PDP

2010

2009

1488 874

[59%]

0.38 0.048372 614 0.01

100

DEEM 

default

RDF#9 PDP Average

0.0305 ppm9

None. Post 

harvest Use.

Citron, Citron 

hybrids, 

Tangerine, 

Kumquat, 

Lemon, Lime, 

Grapefruit, 

Pummelo

Translate PDP Orange Fruit Data

Orange Juice juice PB PDP

2012

2011

2010

1106 98

[9%]

0.051 0.015694 1008 0.03 1.0; using 

PDP juice 

data

RDF#8 PDP Average

0.0151 ppm9

Tangerine, 

Lemon, Lime,

Grapefruit

Translate PDP Orange Juice Data

Orange 

Lemon 

peel PB Tolerance Not Applicable (N/A) 3.312 Tolerance 10.0 ppm

Citrus oil B Tolerance Not Applicable (N/A) DEEM 

default

Tolerance 15.0 ppm
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Table 1. Data and Residue Estimates Used in the Dietary Exposure Analyses.

RAC Food

Forms

Blending

Classification1

Data

Source2

Number

of

Samples

Detectable Residues Non-Detectable

Residues

%CT3 Processing

Factors4

Anticipated Residue 

Estimates/Tolerance5

Factor

for 

Metabolite6

Number

[Percent]

Max

(ppm)

Average

(ppm) Number

Max.

LOD/LOQ

(ppm)

Acute Chronic

Pome Fruits (Crop Group 11)

Apple fruit PB or 

NB

PDP

2010

2009

1488 116213

[78%]

7.4 0.350579 326 0.003

100

DEEM 

default

RDF#2 PDP Average

0.2741 ppm9

None. Post 

harvest Use.

juice PB PDP

2012

2008

2007

610 183

[30%]

0.32 0.060123 427 0.003 1.0; using 

PDP juice 

data

RDF#1 PDP Average

0.0191 ppm9

sauce PB PDP

2006

744 289

[39%]

1.2 0.094191 455 0.03 DEEM

default

RDF#17 PDP Average

0.0458 ppm9

saucebaby foodPB PDP

2012

396 0 -- -- 396 0.003 PDP Maximum/Average

0.0015 ppm (1⁄2LOD)

dried B Translate PDP Apple Fruit Data DEEM

Default

8.0

PDP Average 0.2741 ppm9

Pear, 

Crabapple, 

Goji berry, 

Loquat, 

Quince

fruit PB or 

NB

Translate PDP Apple Fruit Data

Note: Older PDP Pear Fruit data (2003-2005; 66% detectable residues and having 

average residue value (Ave. 0.36 ppm) similar to the average residue value in/on 

apple (Ave. 0.39 ppm) during same time period (2004-2005)) were not used and 

the newer PDP Pear Fruit data (2009 and 2010) did not include analysis for 

thiabendazole.

DEEM

default

RDF#2 PDP Average

0.2741 ppm9

Pear baby food PB PDP

2011

2010

776 177

[23%]

0.90 0.025698 599 0.001 RDF#10 PDP Average

0.0062 ppm9

juice PB Translate PDP Apple Juice Data RDF#1 PDP Average

0.0191 ppm9

dried B Translate PDP Apple Fruit Data DEEM 

default 

6.25

PDP Average 0.2741ppm9

Members of Berries (Crop Group 13)

Strawberry11 fruit PB PDP

2009

2008

981 11

[1%]

0.14 0.027773 970 0.03 100 DEEM 

default

RDF#11 PDP Average

0.0151 ppm9

1.8x

juice Translate PDP Strawberry Fruit Data
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 21 of 47

Table 1. Data and Residue Estimates Used in the Dietary Exposure Analyses.

RAC Food

Forms

Blending

Classification1

Data

Source2

Number

of

Samples

Detectable Residues Non-Detectable

Residues

%CT3 Processing

Factors4

Anticipated Residue 

Estimates/Tolerance5

Factor

for 

Metabolite6

Number

[Percent]

Max

(ppm)

Average

(ppm) Number

Max.

LOD/LOQ

(ppm)

Acute Chronic

Members of Cereal Grains (Crop Group 15)

Corn, field grain B Tolerance 

at LOQ 

(0.01 

ppm)

Not Applicable (N/A) 100 DEEM 

default; no 

longer 

includes 

1.5 for 

syrup 

(DESAC 

1/23/14)

Tolerance (0.01 ppm) at 

LOQ; Used 0.005 ppm 

(1⁄2LOQ)

None.

flour

germ

bran

starch

syrup

oil

Corn, pop grain

Corn, sweet grain PB or 

NB

Wheat grain B Tolerance

48996703

Not Applicable (N/A) max. 

2.5

ave. 1

DEEM 

default

Recommended Lower 

Tolerance in/on Grain (from 

1.0 to 0.05 ppm)

14; Used 

0.05 ppm. Residues do not 

concentrate in processed 

commodities

None. 

Estimate

includes all 

residues of 

concern.

flour

germ

bran

Triticale flour B Translate Wheat flour 100

Barley all food 

forms

B Tolerance Not Applicable (N/A) 100 DEEM 

default

Tolerance 0.05 ppm None.

Oat

Rye

Members of Edible Fungi (Crop Group 21)

Mushrooms fungus PB PDP

2012

2011

930 494

[53%]

3.9 0.344241 436 0.003 100 DEEM 

default

RDF#14 PDP Average

0.1836 ppm9

1.8x
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 22 of 47

Table 1. Data and Residue Estimates Used in the Dietary Exposure Analyses.

RAC Food

Forms

Blending

Classification1

Data

Source2

Number

of

Samples

Detectable Residues Non-Detectable

Residues

%CT3 Processing

Factors4

Anticipated Residue 

Estimates/Tolerance5

Factor

for 

Metabolite6

Number

[Percent]

Max

(ppm)

Average

(ppm) Number

Max.

LOD/LOQ

(ppm)

Acute Chronic

Other Fruit and Vegetables

Avocado11 fruit NB PDP

2012

372 0 -- -- 372 0.003 100 DEEM 

default

PDP Maximum/Average

0.0015 ppm (1⁄2LOD)

1.8x

Banana fruit PB or 

NB

PDP

2012

2007

2006

2045 1228

[60%]

0.74 0.036729 817 0.03 100 DEEM 

default

RDF#3 PDP Average

0.0280 ppm9

None. Post 

harvest Use.

baby food PB or 

NB

Translate PDP Banana Fruit Data

dried B Translate PDP Banana Fruit Data DEEM 

Default 

3.9

PDP Average 0.0280 ppm9

Mango fruit NB PDP

2010

372 58 1.5 0.472259 314 0.01 100 DEEM 

default

RDF#13 PDP Average

0.0779 ppm9

baby food PB Translate PDP Mango Fruit Data

dried NB

juice PB

Papaya fruit PB or 

NB

PDP

2012

2011

749 26

[3%]

0.505 0.242115 723 0.15 100 DEEM 

default

RDF#15 PDP Average

0.0808 ppm9

baby food PB Translate PDP Papaya Fruit Data RDF#15 PDP Average

0.08089

dried B DEEM 

default

1.8

PDP Average 0.0808 ppm9

juice PB DEEM 

default

1.5

RDF#15 PDP Average

0.0808 ppm9

Plantain fruit PB or 

NB

Translate PDP Banana Fruit Data 100 DEEM 

default

RDF#3 PDP Average

0.0280 ppm9

dried B DEEM 

default

3.9

PDP Average 0.0280 ppm9
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 23 of 47

Table 1. Data and Residue Estimates Used in the Dietary Exposure Analyses.

RAC Food

Forms

Blending

Classification1

Data

Source2

Number

of

Samples

Detectable Residues Non-Detectable

Residues

%CT3 Processing

Factors4

Anticipated Residue 

Estimates/Tolerance5

Factor

for 

Metabolite6

Number

[Percent]

Max

(ppm)

Average

(ppm) Number

Max.

LOD/LOQ

(ppm)

Acute Chronic

Meat and Milk

Fat, except beef (including pork skin) Feeding Study (MRID 40271707) and supported by metabolism data.

These estimates which are based on exposure to thiabendazole-treated feedstuffs will also 

cover anticipated residues of thiabendazole in these tissues from the use of thiabendazole as 

an animal drug regulated by FDA.

DEEM 

default

Maximum Residues

0.005 ppm

None. 

Estimate 

includes all 

residues of 

concern.

Kidney and meat byproducts Maximum Residues

0.2 ppm

Liver Maximum Residues

0.07 ppm

Meat, except beef Maximum Residues

0.001 ppm

Milk PDP and FT and supported by metabolism data.

There are extensive PDP data available for milk (2004-2005) which found no detectable 

residues of thiabendazole (<0.001 ppm) in 1485 samples and for heavy cream (2007) which 

found no detectable residues of thiabendazole (<0.008 ppm) or 5-hydroxythiabendazole 

(<0.025 ppm) in 742 samples. [Note: Heavy cream samples from 2005 and all milk 

samples were not analyzed for residues of 5-hydroxythiabendazole.] Milk samples were not 

analyzed of residues of 5-hydroxythiabendazole; however, based on the cattle feeding study 

(MRID 40271707), residues of 5-hydroxythiabendazole (free and conjugated) could be 

estimated at an order of magnitude greater that parent. Hence, the estimated combined 

residues of parent and 5-hydroxythiabendazole (free and conjugated) in milk would be 

< 0.01 ppm. Based on available metabolism data, residues of benzimidazole are not 

expected in milk.

Maximum Residues

0.01 ppm

Beef, fat FDA Tolerance under 21 CFR 556.730 as prescribed under 21 CFR 558.615.

These estimates which are based on exposure to thiabendazole used as an animal drug 

regulated by FDA will also cover anticipated residues of thiabendazole in these tissues from 

exposure to thiabendazole-treated feedstuffs.

Tolerance (0.1 ppm) at 

LOQ; Used 0.05 ppm 

(1⁄2LOQ).

Beef, meat

Beef dried DEEM 

Default 

1.92

1. Blending Classification: blended (B), partially blended (PB), not blended (NB).

2. Data Source: USDA Pesticide Data Program (PDP) with years included, field trial data (FT) with MRID included, tolerance (Tol).

3. Percent Crop Treated (%CT or PCT) based on Screening Level Estimates of Agricultural Uses (SLUA) for Thiabendazole (060101) dated 2/22/13 for reporting timeframe 2004-2011. Only 

available for seed treatment uses on potatoes, soybeans, and wheat. Note: The %CT for seed treatment use on potato is not useful since there is also a post harvest (PH) use on potato which is 

the basis for the tolerance in/on potato.

4. Unless otherwise noted used DEEM default processing factors.

5. RDF = Residue Distribution File. See Attachment 2 for details. Except where noted, non-detectable residues were assigned a value equal to 1⁄2 the method limit of detection (LOD) for USDA 

PDP data or 1⁄2 the method limit of quantitation (LOQ) for field trial data.

6. Because USDA PDP monitoring data did not include benzimidazole (free and conjugated), an additional factor, based on available metabolism data reflecting foliar use, was applied to sweet 

potato/yam, avocado, cantaloupe, strawberry and mushrooms to account for this residue. Based on re-evaluation of the available foliar metabolism data, the reviewer has determined that total 

thiabendazole residues of concern in soybean (foliage, immature plant, straw and seed), sugar beet roots, sugar beet tops and wheat (foliage, forage, straw and grain) may be estimated by 
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 24 of 47

multiplying the thiabendazole residue level by 1.5x, 1.4x, 1.8x and 1.8x, respectively. The factor applied to sweet potato/yam (seed piece uses) was based on sugar beet root metabolism data 

(1.4x) and the factor applied to avocado, cantaloupe, strawberry and mushrooms was based on the maximum factor identified in any of the metabolism studies (1.8x). [Note: There are no U.S. 

registered uses on avocado, cantaloupe, and strawberry. While the tolerances in/on these commodities would suggest post harvest uses, the USDA PDP data found very low levels of detects and 

frequency of detects.] Post harvest treatments are expected to result in the highest potential residues of thiabendazole per se in/on plant commodities and potential residues of benzimidazole (free 

and conjugated) are unlikely to contribute significantly to the total thiabendazole residues of concern in these cases. Hence, an additional factor was not needed for post harvest uses. An 

additional factor was not needed for tolerances which include all residues of concern.

7. Tolerances in/on sugar beet commodities expired 10/25/10 and there are no currently registered uses of thiabendazole on sugar beets (email dated 1/7/14 from R. Jones (PRD) to J. Kidwell 

(HED)).

8. Note that maximum detect residue level (0.004 ppm) is lower than maximum LOD (0.03 ppm).

9. Average USDA PDP Residue Calculations:

Apple Fruit. ((1162 x 0.350579 ppm) + (326 x 0.0015 ppm (1⁄2LOD))) ÷ 1488 = 0.2741 ppm

Apple Juice. ((183 x 0.060123 ppm) + (427 x 0.0015 ppm (1⁄2LOD))) ÷ 610 = 0.0191 ppm

Apple Sauce. ((289 x 0.094191 ppm) + (455 x 0.015 ppm (1⁄2LOD))) ÷ 744 = 0.0458 ppm

Banana Fruit. ((1228 x 0.036729 ppm) + (817 x 0.015 ppm (1⁄2LOD))) ÷ 2045 = 0.0280 ppm

Cantaloupe Fruit. ((5 x 0.0662 ppm) + (1477 x 0.005 ppm (1⁄2LOD))) ÷ 1482 = 0.0052 ppm

Carrot Root. ((6 x 0.002567 ppm) + (1482 x 0.015 ppm (1⁄2LOD))) ÷ 1488 = 0.0149 ppm

Mango Fruit. ((58 x 0.472259 ppm) + (314 x 0.005 ppm (1⁄2LOD))) ÷ 372 = 0.0779 ppm

Mushrooms Fruit. ((494 x 0.344241 ppm) + (436 x 0.0015 ppm (1⁄2LOD))) ÷ 930 = 0.1836 ppm

Orange Fruit. ((874 x 0.048372 ppm) + (614 x 0.005 ppm (1⁄2LOD))) ÷ 1488 = 0.0305 ppm

Orange Juice. ((98 x 0.015694 ppm) + (1008 x 0.015 ppm (1⁄2LOD))) ÷ 1106 = 0.0151 ppm

Papaya Fruit. ((26 x 0.242115 ppm) + (723 x 0.075 ppm (1⁄2LOD))) ÷ 749 = 0.0808 ppm

Pear Baby Food. ((177 x 0.025698 ppm) + (599 x 0.0005 ppm (1⁄2LOD))) ÷ 776 = 0.0062 ppm

Potato Tuber. ((114 x 0.195919 ppm) + (1374 x 0.015 ppm (1⁄2LOD))) ÷ 1488 = 0.0289 ppm

Strawberry Fruit. ((11 x 0.027773 ppm) + (970 x 0.015 ppm (1⁄2LOD))) ÷ 981 = 0.0151 ppm

Sweet Potato Tuber. ((8 x 0.006125 ppm) + (1468 x 0.005 ppm (1⁄2LOD))) ÷ 1476 = 0.0050 ppm

10 Post Harvest use on potato. Residues of thiabendazole did not concentrate in potato flakes, chips and wet peel (MRID 42660302; D189323, 8/3/93, J. Abbotts and MRID 43531002; D214188, 

1/12/99, S. Mason).

11. Not registered for use in the U.S. USDA PDP data were used to estimate residues in/on these commodities. Did not exclude domestic samples from the analyses since domestic samples may 

also be consumed and did not estimate residue in/on domestic samples at nil. All domestic and non-domestic samples with non-detectable residues were handled in the same manner.

12. Post harvest use on citrus suggests that most of the residues are in/on the peel; hence, the maximum theoretical concentration factor for citrus peel (3.3x) was applied to the tolerance.

13. Three tolerance-exceeding residues: (1) 7.4 ppm Chile 2010, (2) 5.9 ppm and 5.7 ppm Washington State 2009

14. The revised Residue Chemistry Chapter to the RED (D267871, 9/7/00, T. Morton) recommended lowering tolerance in/on wheat to 0.2 ppm. Residues of concern were <0.15 ppm in/on wheat 

grain from 1x seed treatment study (D207850, 1/8/99, S. Mason) conducted at 3.6 oz ai/100 lb seed. Residues of concern were <0.1 ppm in grain, dust, bran, middlings, shorts, red dog, low 

grade flour and patent flower from study conducted at an exaggerated rate and used to determine residues in processed commodities. New wheat field trial and processing data (MRID 48996703) 

have been submitted (Petition 3F8166; D410807/D410833/D313507, S. Hummel, 2/25/14). In wheat grown from seed treated with thiabendazole at 0.08-0.14 lb ai/A (90-157 g ai/ha), residues 

of thiabendazole and benzimidazole were each below the LOQ (<0.01 ppm) in/on wheat grain; combined residues were <0.02 ppm in/on all samples of wheat grain. Residues did not 

concentration in wheat grain processed commodities (bran, flour, middlings, shorts, and germ). HED has recommended that the current tolerance in/on wheat grain be lowered from 1.0 ppm 

(established for foliar uses that no longer exist) to 0.05 ppm. 
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 25 of 47

Attachment 2. Residue Distribution Files for the Acute Analyses 

RDF#17 Apple Sauce PDP 2006

TotalZ=0

TotalLOD=455

LODRES=0.015

RDF#1 Apple Juice PDP 2007 2008 2012

TotalZ=0

TotalLOD=427

LODRES=0.0015

1.2

0.73

0.68

0.61

0.59

0.58

0.54

0.52

0.5

0.46

0.46

0.45

0.36

0.36

0.35

0.35

0.35

0.35

0.35

0.35

0.34

0.34

0.33

0.32

0.32

0.32

0.31

0.31

0.31

0.31

0.3

0.29

0.28

0.28

0.27

0.26

0.26

0.26

0.24

0.23

0.23

0.22

0.22

0.22

0.21

0.21

0.21

0.21

0.2

0.2

0.2

0.19

0.19

0.19

0.18

0.18

0.18

0.18

0.18

0.17

0.17

0.17

0.17

0.16

0.15

0.15

0.15

0.15

0.14

0.14

0.14

0.14

0.14

0.13

0.13

0.13

0.13

0.13

0.13

0.13

0.13

0.12

0.12

0.12

0.11

0.11

0.11

0.099

0.097

0.089

0.088

0.088

0.087

0.084

0.083

0.078

0.075

0.074

0.073

0.073

0.069

0.064

0.06

0.06

0.059

0.052

0.052

0.05

0.05

0.05

0.05

0.05

0.048

0.048

0.048

0.047

0.046

0.045

0.044

0.044

0.043

0.042

0.041

0.039

0.038

0.038

0.037

0.036

0.035

0.032

0.031

0.031

0.03

0.03

0.03

0.029

0.027

0.026

0.024

0.024

0.023

0.021

0.021

0.02

0.02

0.02

0.018

0.018

0.018

0.017

0.016

0.016

0.016

0.015

0.015

0.014

0.014

0.013

0.013

0.013

0.011

0.011

0.011

0.011

0.01

0.01

0.01

0.0097

0.0096

0.0095

0.0091

0.009

0.0083

0.0081

0.0081

0.008

0.0079

0.0074

0.0073

0.0071

0.0069

0.0068

0.0067

0.0067

0.0065

0.0063

0.0063

0.0058

0.0055

0.0055

0.0054

0.0052

0.005

0.0049

0.0048

0.0046

0.0046

0.0045

0.0042

0.0042

0.0036

0.0036

0.0035

0.0035

0.0035

0.0034

0.0033

0.0033

0.0031

0.003

0.003

0.003

0.003

0.0029

0.0027

0.0025

0.0023

0.0022

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.0019

0.0015

0.0015

0.0014

0.0012

0.001

0.001

0.0009

0.0009

0.0008

0.0008

0.0008

0.0007

0.0007

0.0007

0.0006

0.0006

0.0005

0.0005

0.0005

0.0005

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.0002

0.46

0.32

0.32

0.3

0.3

0.28

0.27

0.26

0.26

0.25

0.25

0.24

0.23

0.22

0.21

0.21

0.2

0.2

0.19

0.18

0.18

0.18

0.18

0.17

0.17

0.17

0.16

0.16

0.14

0.14

0.13

0.13

0.13

0.12

0.11

0.11

0.11

0.1

0.094

0.093

0.089

0.087

0.086

0.081

0.08

0.078

0.076

0.074

0.074

0.072

0.071

0.071

0.07

0.067

0.06

0.06

0.055

0.054

0.053

0.051

0.049

0.044

0.043

0.038

0.038

0.037

0.034

0.034

0.033

0.032

0.032

0.032

0.03

0.03

0.029

0.028

0.028

0.028

0.027

0.027

0.027

0.026

0.025

0.025

0.024

0.024

0.024

0.024

0.023

0.021

0.021

0.02

0.02

0.019

0.019

0.018

0.017

0.017

0.017

0.017

0.017

0.017

0.017

0.017

0.016

0.016

0.016

0.015

0.014

0.014

0.013

0.013

0.013

0.012

0.011

0.01

0.01

0.01

0.01

0.0099

0.009

0.009

0.0089

0.0086

0.0086

0.008

0.008

0.008

0.0072

0.007

0.007

0.007

0.007

0.007

0.0067

0.0062

0.006

0.006

0.006

0.006

0.006

0.006

0.006

0.0058

0.0056

0.0056

0.0054

0.005

0.005

0.005

0.005

0.0044

0.0043

0.004

0.004

0.004

0.004

0.004

0.004

0.0037

0.0036

0.003

0.003

0.003

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 26 of 47

RDF #14; Mushrooms; PDP 2011 and 2012

TotalZ=0

TotalLOD=436

LODRES=0.0015

3.9

2.1

2

1.9

1.8

1.8

1.8

1.8

1.5

1.5

1.5

1.4

1.4

1.4

1.3

1.3

1.3

1.3

1.3

1.1

1.1

1.1

1.1

1

1

1

1

1

0.99

0.97

0.96

0.93

0.92

0.91

0.91

0.9

0.9

0.88

0.88

0.87

0.87

0.86

0.85

0.85

0.83

0.83

0.82

0.81

0.81

0.81

0.8

0.8

0.8

0.8

0.79

0.77

0.75

0.74

0.74

0.74

0.73

0.72

0.72

0.72

0.71

0.71

0.7

0.7

0.69

0.68

0.68

0.68

0.67

0.67

0.67

0.66

0.66

0.66

0.66

0.64

0.64

0.64

0.64

0.64

0.63

0.62

0.62

0.61

0.6

0.6

0.59

0.59

0.59

0.59

0.59

0.59

0.58

0.58

0.58

0.57

0.57

0.57

0.57

0.56

0.55

0.55

0.54

0.54

0.54

0.52

0.52

0.52

0.52

0.51

0.51

0.51

0.5

0.5

0.49

0.49

0.49

0.49

0.49

0.49

0.49

0.49

0.49

0.47

0.46

0.46

0.46

0.46

0.46

0.46

0.45

0.44

0.43

0.43

0.43

0.42

0.42

0.42

0.42

0.41

0.41

0.41

0.4

0.4

0.4

0.39

0.39

0.39

0.39

0.38

0.38

0.38

0.38

0.38

0.38

0.38

0.37

0.37

0.37

0.37

0.37

0.37

0.36

0.36

0.36

0.36

0.36

0.36

0.36

0.35

0.35

0.35

0.35

0.35

0.34

0.34

0.34

0.34

0.33

0.33

0.33

0.33

0.32

0.32

0.32

0.31

0.31

0.31

0.31

0.31

0.31

0.3

0.3

0.3

0.3

0.3

0.3

0.3

0.3

0.297

0.29

0.29

0.29

0.29

0.29

0.28

0.28

0.28

0.28

0.28

0.28

0.28

0.28

0.28

0.27

0.27

0.27

0.27

0.27

0.26

0.26

0.26

0.26

0.26

0.26

0.25

0.25

0.25

0.25

0.25

0.25

0.25

0.25

0.25

0.24

0.24

0.24

0.24

0.24

0.24

0.23

0.23

0.23

0.22

0.22

0.22

0.22

0.22

0.22

0.22

0.21

0.21

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0.21

0.21

0.21

0.21

0.2

0.2

0.2

0.2

0.2

0.2

0.2

0.2

0.2

0.19

0.19

0.19

0.19

0.19

0.18

0.18

0.18

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0.17

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0.15

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0.14

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0.14

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0.13

0.13

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0.13

0.13

0.13

0.12

0.12

0.12

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0.12

0.12

0.12

0.12

0.12

0.12

0.11

0.11

0.11

0.11

0.11

0.11

0.1

0.1

0.1

0.1

0.1

0.1

0.099

0.096

0.091

0.09

0.09

0.089

0.088

0.086

0.086

0.084

0.083

0.083

0.082

0.082

0.081

0.081

0.077

0.076

0.076

0.076

0.076

0.074

0.074

0.074

0.072

0.071

0.07

0.07

0.07

0.066

0.065

0.065

0.064

0.064

0.062

0.062

0.062

0.061

0.061

0.06

0.059

0.059

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0.057

0.056

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0.049

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0.039

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0.003
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 27 of 47

RDF#9; Oranges, PDP 2009 and 2010

TotalZ=0

TotalLOD=614

LODRES=0.005

0.38

0.36

0.31

0.3

0.3

0.3

0.3

0.29

0.28

0.27

0.25

0.24

0.24

0.24

0.24

0.24

0.24

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0.23

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0.19

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0.159

0.15

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0.15

0.149

0.14

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0.13

0.13

0.13

0.13

0.13

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0.13

0.13

0.13

0.13

0.13

0.13

0.126

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.11

0.11

0.11

0.11

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0.11

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0.1

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0.098

0.097

0.097

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0.079

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0.07

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0.069

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Continued

on next

page
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 28 of 47

RDF#9; Oranges; PDP Continued from previous page

TotalZ=0

TotalLOD=614

LODRES=0.005

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Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 29 of 47

RDF#2; Apples; PDP2009 and 2010

TotalZ=0

TotalLOD=326

LODRES=0.0015

7.4

5.9

5.7

4.6

4.3

4.1

3.9

3.4

3.3

3.124

3.1

3.1

3

3

2.6

2.6

2.5

2.5

2.4

2.4

2.4

2.3

2.3

2.3

2.23

2.2

2.2

2.1

2.1

2.1

2

2

2

1.9

1.9

1.9

1.884

1.82

1.8

1.8

1.8

1.8

1.8

1.7

1.7

1.7

1.7

1.7

1.6

1.6

1.6

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1.6

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.5

1.48

1.4

1.4

1.4

1.4

1.4

1.3

1.3

1.3

1.3

1.3

1.3

1.3

1.3

1.3

1.3

1.3

1.25

1.2

1.2

1.2

1.2

1.2

1.2

1.2

1.2

1.2

1.2

1.2

1.2

1.2

1.2

1.2

1.2

1.2

1.2

1.2

1.2

1.2

1.2

1.2

1.13

1.1

1.1

1.1

1.1

1.1

1.1

1.1

1.1

1.1

1.1

1.1

1

1

1

1

1

0.97

0.97

0.96

0.96

0.96

0.96

0.95

0.95

0.946

0.94

0.94

0.92

0.91

0.91

0.9

0.9

0.9

0.89

0.87

0.87

0.86

0.86

0.85

0.85

0.85

0.84

0.84

0.83

0.83

0.83

0.83

0.83

0.82

0.82

0.82

0.81

0.81

0.81

0.8

0.8

0.8

0.791

0.79

0.79

0.79

0.79

0.78

0.77

0.77

0.77

0.764

0.76

0.76

0.76

0.75

0.75

0.74

0.74

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0.74

0.74

0.73

0.73

0.72

0.72

0.72

0.71

0.71

0.71

0.71

0.7

0.69

0.69

0.69

0.68

0.66

0.66

0.651

0.65

0.65

0.64

0.64

0.64

0.64

0.64

0.63

0.62

0.61

0.61

0.61

0.61

0.59

0.59

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0.56

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0.51

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0.51

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0.51

0.51

0.51

0.51

0.5

0.5

0.49

0.49

0.49

0.49

0.49

0.49

0.49

0.48

0.48

0.48

0.48

0.48

0.48

0.48

0.471

0.47

0.47

0.47

0.47

0.47

0.46

0.456

0.45

0.45

0.45

0.45

0.44

0.44

0.44

0.438

0.43

0.43

0.43

0.43

0.43

0.42

0.42

0.42

0.42

0.41

0.41

0.41

0.41

0.41

0.41

0.4

0.4

0.4

0.4

0.4

0.4

0.4

0.39

0.39

0.39

0.39

0.39

0.39

0.38

0.38

0.38

0.38

0.38

0.38

0.38

0.37

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0.36

0.36

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0.36

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0.36

0.36

0.36

0.36

0.36

0.36

0.36

0.35

0.35

0.35

0.35

0.35

0.35

0.34

0.34

0.34

0.34

0.33

0.33

0.33

0.33

0.32

0.32

0.32

0.32

0.32

0.32

0.32

0.32

0.317

0.31

0.31

0.31

0.303

0.3

0.3

0.3

0.3

0.3

0.3

0.29

0.29

0.29

0.29

0.29

0.29

0.29

0.28

0.28

0.28

0.28

0.28

0.28

0.28

0.27

0.27

0.27

0.27

0.27

0.27

0.268

0.26

0.26

0.26

0.26

0.26

0.26

0.26

0.26

0.25

0.25

0.25

0.25

0.25

0.25

0.25

0.25

0.25

0.25

0.24

0.24

0.24

0.24

0.24

0.24

0.24

0.24

0.24

0.238

0.232

0.23

0.23

0.23

0.23

0.23

0.22

0.22

0.22

0.22

0.22

0.21

0.21

0.21

0.21

0.21

0.21

0.21

0.21

0.21

0.2

0.2

0.2

0.2

0.2

0.2

0.2

0.2

0.2

0.2

0.2

0.2

0.2

0.19

0.19

0.19

0.18

0.18

0.18

0.18

0.18

0.18

0.18

0.178

0.17

0.17

0.17

0.17

0.17

0.17

0.17

0.17

0.17

0.17

0.16

0.16

0.16

0.16

0.16

0.16

0.16

0.15

0.15

0.15

0.15

0.15

0.15

0.15

0.14

0.14

0.13

0.13

0.13

0.13

0.13

0.13

0.13

0.13

0.13

0.13

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.11

0.11

0.11

0.11

0.11

0.11

0.11

0.11

0.11

0.1

0.1

0.1

0.1

0.1

0.098

0.098

0.097

0.096

0.096

0.095

0.095

0.094

0.094

0.093

0.093

0.092

0.091

0.0908

0.09

0.089

0.088

0.087

0.082

0.081

0.081

0.08

0.0794

0.074

0.074

0.073

0.072

0.071

0.067

0.066

0.066

0.065

0.062

0.06

0.059

0.058

0.057

0.056

0.054

0.054

0.053

0.052

0.051

0.049

0.049

0.048

0.048

0.0477

0.047

0.044

0.044

0.043

0.042

0.04

0.039

0.039

0.039

0.037

0.035

0.034

0.033

0.032

0.032

0.032

0.032

0.031

0.031

0.031

0.031

0.031

0.031

0.03

0.028

0.028

0.028

0.027

0.027

0.026

0.026

0.026

0.025

0.025

0.025

0.025

0.024

0.024

0.024

0.024

0.024

0.023

0.023

Continued 

on next 

page
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 30 of 47

RDF#2; Apples; PDP - Continued from previous page

TotalZ=0

TotalLOD=326

LODRES=0.0015

0.023

0.022

0.022

0.022

0.0219

0.021

0.021

0.021

0.021

0.021

0.02

0.019

0.019

0.018

0.018

0.018

0.018

0.018

0.017

0.017

0.016

0.016

0.016

0.016

0.016

0.016

0.015

0.015

0.015

0.015

0.015

0.015

0.015

0.014

0.014

0.014

0.014

0.014

0.014

0.014

0.0138

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.0115

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.01

0.01

0.01

0.01

0.01

0.01

0.01

0.01

0.0099

0.0097

0.0097

0.0095

0.0095

0.0094

0.0094

0.0093

0.0093

0.0092

0.0092

0.0091

0.0088

0.0086

0.0086

0.0086

0.0085

0.0085

0.0085

0.0084

0.0082

0.0082

0.0081

0.008

0.0079

0.0079

0.0079

0.0079

0.0079

0.0077

0.0077

0.0076

0.0076

0.0076

0.0075

0.0075

0.0075

0.0074

0.0074

0.0074

0.0074

0.0072

0.0072

0.007

0.007

0.0069

0.0069

0.0068

0.0068

0.0066

0.0066

0.0066

0.0066

0.0066

0.0065

0.0065

0.0065

0.0064

0.0064

0.0064

0.0063

0.0061

0.0061

0.006

0.006

0.006

0.006

0.006

0.006

0.0059

0.0059

0.0059

0.0058

0.0057

0.0057

0.0057

0.0057

0.0056

0.0056

0.0055

0.0055

0.0054

0.0054

0.0054

0.0054

0.0054

0.0054

0.0053

0.0052

0.0052

0.0052

0.0051

0.0051

0.0051

0.0051

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.0049

0.0049

0.0049

0.0049

0.0049

0.0048

0.0048

0.0048

0.0048

0.0048

0.0048

0.0047

0.0047

0.0047

0.0047

0.0046

0.0046

0.0046

0.0046

0.0046

0.0046

0.0045

0.0045

0.0045

0.0043

0.0043

0.0043

0.0043

0.0043

0.0043

0.0043

0.0043

0.0043

0.0042

0.0042

0.0042

0.0041

0.0041

0.0041

0.004

0.004

0.004

0.004

0.0039

0.0039

0.0038

0.0038

0.0038

0.0038

0.0037

0.0037

0.0037

0.0037

0.0036

0.0036

0.0035

0.0035

0.0034

0.0034

0.0034

0.0033

0.0033

0.0033

0.0033

0.0032

0.0032

0.0032

0.0032

0.0032

0.0032

0.0032

0.0032

0.0032

0.0031

0.0031

0.0031

0.0031

0.0031

0.0031

0.0031

0.0031

0.0031

0.003

0.003

0.003

0.003

0.003

0.003

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

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0.0017

0.0017

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0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 31 of 47

RDF#8; Orange Juice; PDP

2010, 2011 and 2012

TotalZ=0

TotalLOD=1008

LODRES=0.015

RDF#10; Pears Baby Food; PDP

2010 and 2011

TotalZ=0

TotalLOD=599

LODRES=0.0005

RDF#13; Mango; PDP

2010

TotalZ=0

TotalLOD=314

LODRES=0.005

RDF#15; Papaya; PDP

2011 and 2012

TotalZ=0

TotalLOD=723

LODRES=0.075

0.051

0.044

0.039

0.038

0.038

0.034

0.031

0.031

0.029

0.029

0.028

0.027

0.026

0.026

0.025

0.025

0.025

0.023

0.022

0.022

0.022

0.021

0.021

0.021

0.021

0.02

0.02

0.02

0.02

0.02

0.02

0.019

0.019

0.019

0.019

0.019

0.018

0.018

0.018

0.018

0.018

0.018

0.018

0.018

0.017

0.017

0.017

0.017

0.017

0.017

0.016

0.016

0.016

0.015

0.015

0.015

0.014

0.012

0.012

0.012

0.011

0.01

0.01

0.01

0.009

0.009

0.009

0.009

0.007

0.007

0.007

0.007

0.007

0.007

0.006

0.006

0.006

0.006

0.005

0.005

0.004

0.004

0.004

0.004

0.004

0.004

0.004

0.004

0.003

0.003

0.003

0.003

0.003

0.003

0.003

0.003

0.003

0.003

0.9

0.31

0.26

0.19

0.11

0.11

0.093

0.088

0.087

0.086

0.085

0.078

0.067

0.065

0.063

0.06

0.055

0.054

0.052

0.051

0.05

0.046

0.043

0.043

0.043

0.043

0.04

0.04

0.039

0.039

0.038

0.035

0.033

0.032

0.031

0.03

0.03

0.03

0.03

0.029

0.028

0.028

0.028

0.028

0.027

0.027

0.025

0.024

0.024

0.022

0.022

0.019

0.019

0.019

0.018

0.018

0.018

0.018

0.018

0.018

0.017

0.016

0.016

0.016

0.015

0.015

0.015

0.014

0.013

0.013

0.012

0.012

0.011

0.0097

0.0095

0.0084

0.0084

0.0079

0.0079

0.0075

0.0073

0.0071

0.0069

0.0066

0.0063

0.0063

0.0059

0.0055

0.0054

0.005

0.005

0.0044

0.0042

0.0041

0.0039

0.0039

0.0038

0.0032

0.0031

0.0031

0.0031

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

0.0017

1.5

1.4

1.3

1.3

1.2

1.2

1.2

0.92

0.82

0.79

0.78

0.76

0.76

0.75

0.74

0.65

0.65

0.61

0.59

0.54

0.49

0.47

0.45

0.43

0.41

0.4

0.4

0.37

0.35

0.34

0.31

0.28

0.28

0.27

0.27

0.25

0.25

0.25

0.24

0.22

0.21

0.2

0.19

0.18

0.18

0.16

0.13

0.13

0.13

0.12

0.11

0.09

0.082

0.078

0.074

0.07

0.043

0.024

0.505

0.45

0.45

0.4

0.38

0.34

0.33

0.32

0.28

0.2

0.2

0.19

0.18

0.18

0.17

0.17

0.16

0.16

0.16

0.16

0.16

0.15

0.15

0.15

0.15

0.15
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 32 of 47

RDF#3; Banana, PDP 2006, 2007 and 2012

TotalZ=0

TotalLOD=817

LODRES=0.015

0.74

0.36

0.23

0.19

0.18

0.18

0.18

0.17

0.17

0.17

0.17

0.16

0.16

0.16

0.15

0.15

0.14

0.14

0.13

0.13

0.13

0.13

0.13

0.13

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.12

0.11

0.11

0.11

0.11

0.11

0.11

0.11

0.11

0.11

0.11

0.11

0.1

0.1

0.1

0.1

0.1

0.1

0.1

0.099

0.099

0.099

0.099

0.099

0.098

0.098

0.097

0.097

0.096

0.096

0.096

0.096

0.095

0.095

0.095

0.095

0.094

0.094

0.093

0.093

0.092

0.092

0.092

0.091

0.091

0.091

0.091

0.09

0.09

0.089

0.089

0.088

0.088

0.088

0.088

0.087

0.087

0.087

0.087

0.085

0.085

0.085

0.085

0.084

0.084

0.083

0.083

0.083

0.083

0.082

0.082

0.082

0.082

0.081

0.081

0.08

0.079

0.078

0.078

0.078

0.077

0.077

0.077

0.077

0.077

0.076

0.076

0.075

0.075

0.075

0.075

0.074

0.074

0.074

0.073

0.073

0.073

0.073

0.073

0.073

0.073

0.072

0.072

0.072

0.071

0.071

0.07

0.07

0.07

0.069

0.069

0.068

0.068

0.068

0.068

0.068

0.068

0.068

0.067

0.067

0.067

0.067

0.067

0.067

0.066

0.066

0.065

0.065

0.065

0.065

0.065

0.065

0.065

0.064

0.064

0.064

0.064

0.064

0.063

0.063

0.063

0.063

0.063

0.062

0.062

0.062

0.062

0.062

0.061

0.061

0.061

0.061

0.061

0.061

0.06

0.06

0.06

0.06

0.06

0.06

0.06

0.06

0.06

0.06

0.06

0.06

0.059

0.059

0.059

0.059

0.059

0.059

0.059

0.059

0.059

0.058

0.058

0.058

0.058

0.058

0.058

0.058

0.058

0.058

0.058

0.058

0.058

0.058

0.057

0.057

0.057

0.057

0.057

0.057

0.057

0.057

0.057

0.056

0.056

0.056

0.056

0.056

0.056

0.056

0.056

0.056

0.056

0.055

0.055

0.055

0.055

0.054

0.054

0.054

0.054

0.054

0.054

0.054

0.054

0.054

0.054

0.054

0.054

0.054

0.054

0.054

0.054

0.053

0.053

0.053

0.053

0.053

0.053

0.053

0.053

0.052

0.052

0.052

0.052

0.052

0.052

0.051

0.051

0.051

0.051

0.051

0.051

0.051

0.051

0.051

0.051

0.051

0.051

0.051

0.051

0.05

0.05

0.05

0.05

0.05

0.05

0.05

0.05

0.05

0.049

0.049

0.049

0.049

0.049

0.049

0.049

0.049

0.049

0.049

0.048

0.048

0.048

0.048

0.048

0.048

0.048

0.048

0.048

0.048

0.048

0.047

0.047

0.047

0.047

0.047

0.047

0.047

0.047

0.047

0.047

0.046

0.046

0.046

0.046

0.046

0.046

0.046

0.046

0.045

0.045

0.045

0.045

0.045

0.045

0.045

0.045

0.045

0.045

0.045

0.045

0.045

0.045

0.045

0.045

0.045

0.044

0.044

0.044

0.044

0.044

0.044

0.044

0.044

0.044

0.044

0.044

0.044

0.044

0.044

0.044

0.044

0.044

0.043

0.043

0.043

0.043

0.043

0.043

0.043

0.043

0.043

0.042

0.042

0.042

0.042

0.042

0.042

0.042

0.042

0.042

0.042

0.042

0.042

0.042

0.042

0.041

0.041

0.041

0.041

0.041

0.041

0.041

0.041

0.041

0.04

0.04

0.04

0.04

0.04

0.04

0.04

0.04

0.04

0.04

0.04

0.04

0.04

0.04

0.039

0.039

0.039

0.039

0.039

0.039

0.039

0.039

0.039

0.039

0.039

0.038

0.038

0.038

0.038

0.038

0.038

0.038

0.038

0.038

0.038

0.038

0.037

0.037

0.037

0.037

0.037

0.037

0.037

0.037

0.037

0.037

0.037

0.037

0.037

0.037

0.037

0.037

0.037

0.037

0.037

0.037

0.036

0.036

0.036

0.036

0.036

0.036

0.036

0.036

0.035

0.035

0.035

0.035

0.035

0.035

0.035

0.035

0.035

0.035

0.034

0.034

0.034

0.034

0.034

0.034

0.034

0.034

0.034

0.034

0.034

0.034

0.034

0.034

0.034

0.034

0.034

0.034

0.034

0.034

0.034

0.033

0.033

0.033

0.033

0.033

0.033

0.033

0.033

0.033

0.033

0.033

0.033

0.033

0.033

0.033

0.033

0.033

0.033

0.033

0.033

0.032

0.032

0.032

0.032

0.032

0.032

0.032

0.032

0.032

0.032

0.032

0.032

0.032

0.032

0.032

0.032

0.032

0.031

0.031

0.031

0.031

0.031

0.031

0.031

0.031

0.031

0.031

0.031

0.031

0.031

0.031

0.031

0.031

0.031

0.031

0.031

0.031

0.031

0.031

0.031

0.03

0.03

0.03

0.03

0.03

0.03

0.03

0.03

0.03

0.03

0.03

0.03

0.03

0.03

0.03

0.03

0.03

0.03

0.03

0.029

0.029

0.029

0.029

0.029

0.029

0.029

0.029

0.029

0.029

0.029

0.029

0.029

0.029

0.029

0.029

0.029

0.029

0.029

0.029

0.029

0.029

0.029

0.028

0.028

0.028

0.028

0.028

0.028

0.028

0.028

0.028

0.028

0.028

0.028

0.028

0.028

0.028

0.028

0.028

0.028

0.028

0.028

0.027

0.027

0.027

0.027

0.027

0.027

0.027

0.027

0.027

0.027

0.027

0.027

0.027

0.027

0.027

0.027

0.026

Continued

on next 

page
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 33 of 47

RDF#3; Banana; PDP - Continued from previous page

TotalZ=0

TotalLOD=817

LODRES=0.015

0.026

0.026

0.026

0.026

0.026

0.026

0.026

0.026

0.026

0.026

0.026

0.026

0.026

0.026

0.026

0.026

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.025

0.024

0.024

0.024

0.024

0.024

0.024

0.024

0.024

0.024

0.024

0.024

0.024

0.024

0.024

0.024

0.024

0.024

0.024

0.024

0.024

0.024

0.024

0.024

0.024

0.024

0.024

0.024

0.024

0.023

0.023

0.023

0.023

0.023

0.023

0.023

0.023

0.023

0.023

0.023

0.023

0.023

0.023

0.023

0.023

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.022

0.021

0.021

0.021

0.021

0.021

0.021

0.021

0.021

0.021

0.021

0.021

0.021

0.021

0.021

0.021

0.021

0.021

0.021

0.021

0.02

0.02

0.02

0.02

0.02

0.02

0.02

0.02

0.02

0.02

0.02

0.02

0.02

0.02

0.02

0.02

0.02

0.02

0.02

0.02

0.019

0.019

0.019

0.019

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0.019

0.019

0.019

0.019

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0.019

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0.019

0.019

0.019

0.019

0.019

0.019

0.018

0.018

0.018

0.018

0.018

0.018

0.018

0.018

0.018

0.018

0.018

0.018

0.018

0.018

0.018

0.018

0.018

0.018

0.018

0.018

0.017

0.017

0.017

0.017

0.017

0.017

0.017

0.017

0.017

0.017

0.017

0.017

0.017

0.017

0.017

0.017

0.017

0.017

0.017

0.017

0.017

0.017

0.017

0.016

0.016

0.016

0.016

0.016

0.016

0.016

0.016

0.016

0.016

0.016

0.016

0.016

0.016

0.016

0.016

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0.016

0.016

0.016

0.016

0.016

0.016

0.016

0.016

0.016

0.016

0.016

0.016

0.016

0.016

0.016

0.015

0.015

0.015

0.015

0.015

0.015

0.015

0.015

0.015

0.015

0.015

0.015

0.015

0.015

0.015

0.015

0.015

0.015

0.015

0.014

0.014

0.014

0.014

0.014

0.014

0.014

0.014

0.014

0.014

0.014

0.014

0.014

0.014

0.014

0.014

0.014

0.014

0.014

0.014

0.014

0.014

0.014

0.014

0.014

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.013

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.012

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.011

0.01

0.01

0.01

0.01

0.01

0.01

0.01

0.01

0.01

0.01

0.01

0.01

0.0099

0.0098

0.0097

0.0097

0.0097

0.0096

0.0095

0.0095

0.0094

0.0093

0.0093

0.0093

0.009

0.009

0.0089

0.0086

0.0085

0.0085

0.0085

0.0083

0.0083

0.0083

0.0081

0.008

0.008

0.008

0.008

0.008

0.0078

0.0078

0.0077

0.0076

0.0076

0.0076

0.0075

0.0074

0.0074

0.0074

0.0074

0.0074

0.0073

0.0073

0.0072

0.0072

0.0071

0.0071

0.007

0.007

0.007

0.0069

0.0069

0.0068

0.0067

0.0067

0.0067

0.0067

0.0067

0.0066

0.0064

0.0064

0.0064

0.0063

0.0062

0.0062

0.0062

0.0062

0.0061

0.0061

0.006

0.0059

0.0059

0.0059

0.0059

0.0058

0.0058

0.0056

0.0055

0.0054

0.0053

0.0052

0.0052

0.0051

0.0051

0.005

0.005

0.005

0.0048

0.0047

0.0046

0.0046

0.0046

0.0046

0.0045

0.0044

0.0044

0.0043

0.0043

0.0043

0.0041

0.004

0.004

0.004

0.0039

0.0039

0.0039

0.0039

0.0038

0.0037

0.0037

0.0035

0.0035

0.0035

0.0035

0.0034

0.0034

0.0033

0.0032

0.003

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002

0.002
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 34 of 47

RDF#4; Cantaloupe; PDP

2010, 2011 and 2012

TotalZ=0

TotalLOD=1477

LODRES=0.005

RDF#5; Carrot; PDP 2006 and 2007

TotalZ=0

TotalLOD=1482

LODRES=0.015

RDF#7; Potato; PDP 2008 and 2009

TotalZ=0

TotalLOD=1374

LODRES=0.015

0.12

0.12

0.06

0.018

0.013

0.004

0.0034

0.002

0.002

0.002

0.002

1.5

1.2

1

1

0.98

0.89

0.84

0.84

0.78

0.72

0.72

0.65

0.65

0.64

0.64

0.62

0.56

0.41

0.35

0.34

0.34

0.34

0.33

0.29

0.28

0.27

0.267

0.266

0.26

0.236

0.234

0.23

0.22

0.21

0.19

0.19

0.16

0.15

0.14

0.14

0.14

0.14

0.12

0.12

0.11

0.1

0.1

0.066

0.062

0.061

0.0501

0.0501

0.0501

0.0501

0.0501

0.0501

0.0501

0.05

0.05

0.05

0.05

0.05

0.05

0.05

0.05

0.05

0.05

0.041

0.039

0.03

0.028

0.022

0.021

0.016

0.015

0.013

0.01

0.008

0.008

0.008

0.007

0.007

0.005

0.005

0.005

0.005

0.005

0.005

0.005

0.0049

0.0044

0.0042

0.004

0.004

0.004

0.004

0.004

0.004

0.004

0.004

0.004

0.004

0.0036

0.003

0.003

0.003

0.003

0.003

0.002

0.002

0.002

0.002

0.002

0.002

RDF#11; Strawberry; PDP

2008 and 2009

TotalZ=0

TotalLOD=970

LODRES=0.015

RDF#12: Sweet Potato, PDP

2008, 2009 and 2010

TotalZ=0

TotalLOD=1468

LODRES=0.005

0.14

0.047

0.037

0.022

0.018

0.015

0.009

0.007

0.005

0.0035

0.002

0.014

0.005

0.005

0.005

0.005

0.005

0.005

0.005
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 35 of 47

Attachment 3. Acute Residue Input file

Filename: 060101ACUTEThiabendazole 3 7 14.R08

Chemical: Thiabendazole

RfD(Chronic): .033 mg/kg bw/day NOEL(Chronic): 10 mg/kg bw/day

RfD(Acute): .05 mg/kg bw/day NOEL(Acute): 50 mg/kg bw/day

Date created/last modified: 03-07-2014/12:26:09 Program ver. 3.16, 03-08-d

-----------------------------------------------------------------------------------

RDL indices and parameters for Monte Carlo Analysis:

Index Dist Parameter #1 Param #2 Param #3 Comment

 # Code 

----- ---- ------------ -------- -------- -------

 1 6 Apple Juice.rdf

 2 6 Apples.rdf

 3 6 Banana.rdf

 4 6 Cantaloupe.rdf

 5 6 Carrot.rdf

 6 6 Frozen Potato.rdf

 7 6 Potato.rdf

 8 6 Orange Juice.rdf

 9 6 Oranges.rdf

 10 6 Pears Baby Food.rdf

 11 6 Strawberry.rdf

 12 6 Sweet Potato.rdf

 13 6 Mango.rdf

 14 6 Mushrooms.rdf

 15 6 Papaya.rdf

 16 6 Wheat flour.rdf

 17 6 Apple Sauce.rdf

 EPA Crop Commodity Name Def Res Adj.Factors RDLComment

 Code Grp (ppm) #1 #2 Pntr

---------- ---- ------------------------------- ---------- ------ ------ --- -------

0101050000 1AB Beet, garden, roots 0.020000 1.000 1.000 

0101050001 1AB Beet, garden, roots-babyfood 0.020000 1.000 1.000 

0101067000 1AB Burdock 0.020000 1.000 1.000 

0101078000 1AB Carrot 10.000000 1.000 1.000 5 

0101078001 1AB Carrot-babyfood 0.002000 1.000 1.000 

0101079000 1AB Carrot, juice 10.000000 1.000 1.000 5 

0101084000 1AB Celeriac 0.020000 1.000 1.000 

0101100000 1AB Chicory, roots 0.020000 1.000 1.000 

0101168000 1AB Ginseng, dried 0.020000 1.000 1.000 

0101190000 1AB Horseradish 0.020000 1.000 1.000 

0101250000 1AB Parsley, turnip rooted 0.020000 1.000 1.000 

0101251000 1AB Parsnip 0.020000 1.000 1.000 

0101251001 1AB Parsnip-babyfood 0.020000 1.000 1.000 

0101314000 1AB Radish, roots 0.020000 1.000 1.000 

0101316000 1AB Radish, Oriental, roots 0.020000 1.000 1.000 

0101327000 1AB Rutabaga 0.020000 1.000 1.000 

0101331000 1AB Salsify, roots 0.020000 1.000 1.000 

0101388000 1AB Turnip, roots 0.020000 1.000 1.000 

0103296000 1C Potato, chips 0.028900 1.000 1.000 Residues Do Not Conc.

0103297000 1C Potato, dry (granules/ flakes) 0.028900 1.000 1.000 Residues Do Not Conc.

0103297001 1C Potato, dry (granules/ flakes)-b 0.028900 1.000 1.000 Residues Do Not Conc.

0103298000 1C Potato, flour 0.028900 1.000 1.000 Residues Do Not Conc.

0103298001 1C Potato, flour-babyfood 0.028900 1.000 1.000 Residues Do Not Conc.

0103299000 1C Potato, tuber, w/peel 10.000000 1.000 1.000 7 

0103299001 1C Potato, tuber, w/peel-babyfood 10.000000 1.000 1.000 7 

0103300000 1C Potato, tuber, w/o peel 10.000000 1.000 1.000 7 

0103300001 1C Potato, tuber, w/o peel-babyfood 10.000000 1.000 1.000 7 

0103366000 1CD Sweet potato 0.050000 1.400 1.000 12 1.4x for benzimidazole

0103366001 1CD Sweet potato-babyfood 0.001500 1.400 1.000 1.4x for benzimidazole

0103406000 1CD Yam, true 0.050000 1.400 1.000 12 1.4x for benzimidazole

0301165000 3A Garlic, bulb 0.020000 1.000 1.000 

0301165001 3A Garlic, bulb-babyfood 0.020000 1.000 1.000 

0301237000 3A Onion, bulb 0.020000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 0.020000 1.000 1.000 

0301238000 3A Onion, bulb, dried 0.020000 1.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 0.020000 1.000 1.000 

0301338000 3A Shallot, bulb 0.020000 1.000 1.000 

0401355000 4A Spinach 0.020000 1.000 1.000 

0401355001 4A Spinach-babyfood 0.020000 1.000 1.000 
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 36 of 47

0501061000 5A Broccoli 0.020000 1.000 1.000 

0501061001 5A Broccoli-babyfood 0.020000 1.000 1.000 

0501062000 5A Broccoli, Chinese 0.020000 1.000 1.000 

0501064000 5A Brussels sprouts 0.020000 1.000 1.000 

0501069000 5A Cabbage 0.020000 1.000 1.000 

0501071000 5A Cabbage, Chinese, napa 0.020000 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 0.020000 1.000 1.000 

0501083000 5A Cauliflower 0.020000 1.000 1.000 

0501196000 5A Kohlrabi 0.020000 1.000 1.000 

0600347000 6 Soybean, seed 0.100000 1.000 0.025 Tol and blended commodity

0600349000 6 Soybean, soy milk 0.100000 1.000 0.025 Tol and blended commodity

0600349001 6 Soybean, soy milk-babyfood or in 0.100000 1.000 0.025 Tol and blended commodity

0600350000 6 Soybean, oil 0.100000 1.000 0.025 Tol and blended commodity

0600350001 6 Soybean, oil-babyfood 0.100000 1.000 0.025 Tol and blended commodity

0603030000 6C Bean, black, seed 0.100000 1.000 1.000 

0603032000 6C Bean, broad, seed 0.100000 1.000 1.000 

0603034000 6C Bean, cowpea, seed 0.100000 1.000 1.000 

0603035000 6C Bean, great northern, seed 0.100000 1.000 1.000 

0603036000 6C Bean, kidney, seed 0.100000 1.000 1.000 

0603038000 6C Bean, lima, seed 0.100000 1.000 1.000 

0603039000 6C Bean, mung, seed 0.100000 1.000 1.000 

0603040000 6C Bean, navy, seed 0.100000 1.000 1.000 

0603041000 6C Bean, pink, seed 0.100000 1.000 1.000 

0603042000 6C Bean, pinto, seed 0.100000 1.000 1.000 

0603098000 6C Chickpea, seed 0.100000 1.000 1.000 

0603098001 6C Chickpea, seed-babyfood 0.100000 1.000 1.000 

0603099000 6C Chickpea, flour 0.100000 1.000 1.000 

0603182000 6C Guar, seed 0.100000 1.000 1.000 

0603182001 6C Guar, seed-babyfood 0.100000 1.000 1.000 

0603203000 6C Lentil, seed 0.005000 1.000 1.000 

0603256000 6C Pea, dry 0.005000 1.000 1.000 

0603256001 6C Pea, dry-babyfood 0.005000 1.000 1.000 

0603258000 6C Pea, pigeon, seed 0.005000 1.000 1.000 

0603348000 6C Soybean, flour 0.100000 1.000 1.000 

0603348001 6C Soybean, flour-babyfood 0.100000 1.000 1.000 

0901075000 9A Cantaloupe 15.000000 1.800 1.000 4 1.8x for benzimidazole

0901187000 9A Honeydew melon 0.020000 1.000 1.000 

0901399000 9A Watermelon 0.020000 1.000 1.000 

0901400000 9A Watermelon, juice 0.020000 1.000 1.000 

0902021000 9B Balsam pear 0.020000 1.000 1.000 

0902088000 9B Chayote, fruit 0.020000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.020000 1.000 1.000 

0902135000 9B Cucumber 0.020000 1.000 1.000 

0902308000 9B Pumpkin 0.020000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.020000 1.000 1.000 

0902356000 9B Squash, summer 0.020000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.020000 1.000 1.000 

0902357000 9B Squash, winter 0.020000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.020000 1.000 1.000 

1001106000 10A Citron 10.000000 1.000 1.000 9 

1001107000 10A Citrus hybrids 10.000000 1.000 1.000 9 

1001108000 10A Citrus, oil 15.000000 1.000 1.000 

1001240000 10A Orange 10.000000 1.000 1.000 9 

1001241000 10A Orange, juice 10.000000 1.000 1.000 8 

1001241001 10A Orange, juice-babyfood 10.000000 1.000 1.000 8 

1001242000 10A Orange, peel 10.000000 3.300 1.000 Conc. for peel

1001369000 10A Tangerine 10.000000 1.000 1.000 9 

1001370000 10A Tangerine, juice 10.000000 1.000 1.000 8 

1002197000 10B Kumquat 10.000000 1.000 1.000 9 

1002199000 10B Lemon 10.000000 1.000 1.000 9 

1002200000 10B Lemon, juice 10.000000 1.000 1.000 8 

1002200001 10B Lemon, juice-babyfood 10.000000 1.000 1.000 8 

1002201000 10B Lemon, peel 10.000000 3.300 1.000 Conc. for peel

1002206000 10B Lime 10.000000 1.000 1.000 9 

1002207000 10B Lime, juice 10.000000 1.000 1.000 8 

1002207001 10B Lime, juice-babyfood 10.000000 1.000 1.000 8 

1003180000 10C Grapefruit 10.000000 1.000 1.000 9 

1003181000 10C Grapefruit, juice 10.000000 1.000 1.000 8 

1003307000 10C Pummelo 10.000000 1.000 1.000 9 

1100007000 11 Apple, fruit with peel 5.000000 1.000 1.000 2 

1100008000 11 Apple, peeled fruit 5.000000 1.000 1.000 2 

1100008001 11 Apple, peeled fruit-babyfood 5.000000 1.000 1.000 2 

1100009000 11 Apple, dried 0.274100 8.000 1.000 

1100009001 11 Apple, dried-babyfood 0.274100 8.000 1.000 

1100010000 11 Apple, juice 5.000000 1.000 1.000 1 
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 37 of 47

1100010001 11 Apple, juice-babyfood 5.000000 1.000 1.000 1 

1100011000 11 Apple, sauce 5.000000 1.000 1.000 17 

1100011001 11 Apple, sauce-babyfood 0.001500 1.000 1.000 

1100129000 11 Crabapple 5.000000 1.000 1.000 2 

1100173500 11 Goji berry 5.000000 1.000 1.000 2 

1100210000 11 Loquat 5.000000 1.000 1.000 2 

1100266000 11 Pear 5.000000 1.000 1.000 2 

1100266001 11 Pear-babyfood 5.000000 1.000 1.000 10 

1100267000 11 Pear, dried 0.274100 6.250 1.000 

1100268000 11 Pear, juice 5.000000 1.000 1.000 1 

1100268001 11 Pear, juice-babyfood 5.000000 1.000 1.000 1 

1100310000 11 Quince 5.000000 1.000 1.000 2 

1307359000 13G Strawberry 5.000000 1.800 1.000 11 1.8x for benzimidazole

1307359001 13G Strawberry-babyfood 5.000000 1.800 1.000 11 1.8x for benzimidazole

1307360000 13G Strawberry, juice 5.000000 1.800 1.000 11 1.8x for benzimidazole

1307360001 13G Strawberry, juice-babyfood 5.000000 1.800 1.000 11 1.8x for benzimidazole

1500025000 15 Barley, pearled barley 0.050000 1.000 1.000 

1500025001 15 Barley, pearled barley-babyfood 0.050000 1.000 1.000 

1500026000 15 Barley, flour 0.050000 1.000 1.000 

1500026001 15 Barley, flour-babyfood 0.050000 1.000 1.000 

1500027000 15 Barley, bran 0.050000 1.000 1.000 

1500120000 15 Corn, field, flour 0.005000 1.000 1.000 

1500120001 15 Corn, field, flour-babyfood 0.005000 1.000 1.000 

1500121000 15 Corn, field, meal 0.005000 1.000 1.000 

1500121001 15 Corn, field, meal-babyfood 0.005000 1.000 1.000 

1500122000 15 Corn, field, bran 0.005000 1.000 1.000 

1500123000 15 Corn, field, starch 0.005000 1.000 1.000 

1500123001 15 Corn, field, starch-babyfood 0.005000 1.000 1.000 

1500124000 15 Corn, field, syrup 0.005000 1.000 1.000 DESAC decision

1500124001 15 Corn, field, syrup-babyfood 0.005000 1.000 1.000 DESAC decision

1500125000 15 Corn, field, oil 0.005000 1.000 1.000 

1500125001 15 Corn, field, oil-babyfood 0.005000 1.000 1.000 

1500126000 15 Corn, pop 0.005000 1.000 1.000 

1500127000 15 Corn, sweet 0.005000 1.000 1.000 

1500127001 15 Corn, sweet-babyfood 0.005000 1.000 1.000 

1500231000 15 Oat, bran 0.050000 1.000 1.000 

1500232000 15 Oat, flour 0.050000 1.000 1.000 

1500232001 15 Oat, flour-babyfood 0.050000 1.000 1.000 

1500233000 15 Oat, groats/rolled oats 0.050000 1.000 1.000 

1500233001 15 Oat, groats/rolled oats-babyfood 0.050000 1.000 1.000 

1500328000 15 Rye, grain 0.050000 1.000 1.000 

1500329000 15 Rye, flour 0.050000 1.000 1.000 

1500381000 15 Triticale, flour 0.050000 1.000 1.000 

1500381001 15 Triticale, flour-babyfood 0.050000 1.000 1.000 

1500401000 15 Wheat, grain 0.050000 1.000 0.025 max res/blended commodity

1500401001 15 Wheat, grain-babyfood 0.050000 1.000 0.025 max res/blended commodity

1500402000 15 Wheat, flour 0.050000 1.000 0.025 max res/blended commodity

1500402001 15 Wheat, flour-babyfood 0.050000 1.000 0.025 max res/blended commodity

1500403000 15 Wheat, germ 0.050000 1.000 0.025 max res/blended commodity

1500404000 15 Wheat, bran 0.050000 1.000 0.025 max res/blended commodity

2100228000 21 Mushroom 40.000000 1.800 1.000 14 1.8x for benzimidazole

3100044000 31 Beef, meat 0.050000 1.000 1.000 FDA tol

3100044001 31 Beef, meat-babyfood 0.050000 1.000 1.000 FDA tol

3100045000 31 Beef, meat, dried 0.050000 1.920 1.000 FDA tol

3100046000 31 Beef, meat byproducts 0.200000 1.000 1.000 max res

3100046001 31 Beef, meat byproducts-babyfood 0.200000 1.000 1.000 max res

3100047000 31 Beef, fat 0.050000 1.000 1.000 FDA tol

3100047001 31 Beef, fat-babyfood 0.050000 1.000 1.000 FDA tol

3100048000 31 Beef, kidney 0.200000 1.000 1.000 max res

3100049000 31 Beef, liver 0.070000 1.000 1.000 max res

3100049001 31 Beef, liver-babyfood 0.070000 1.000 1.000 max res

3200169000 32 Goat, meat 0.001000 1.000 1.000 max res

3200170000 32 Goat, meat byproducts 0.200000 1.000 1.000 max res

3200171000 32 Goat, fat 0.005000 1.000 1.000 max res

3200172000 32 Goat, kidney 0.200000 1.000 1.000 max res

3200173000 32 Goat, liver 0.070000 1.000 1.000 max res

3300189000 33 Horse, meat 0.001000 1.000 1.000 max res

3400290000 34 Pork, meat 0.001000 1.000 1.000 max res

3400290001 34 Pork, meat-babyfood 0.001000 1.000 1.000 max res

3400291000 34 Pork, skin 0.005000 1.000 1.000 max res

3400292000 34 Pork, meat byproducts 0.200000 1.000 1.000 max res

3400292001 34 Pork, meat byproducts-babyfood 0.200000 1.000 1.000 max res

3400293000 34 Pork, fat 0.005000 1.000 1.000 max res

3400293001 34 Pork, fat-babyfood 0.005000 1.000 1.000 max res

3400294000 34 Pork, kidney 0.200000 1.000 1.000 max res
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 38 of 47

3400295000 34 Pork, liver 0.070000 1.000 1.000 max res

3500339000 35 Sheep, meat 0.001000 1.000 1.000 max res

3500339001 35 Sheep, meat-babyfood 0.001000 1.000 1.000 max res

3500340000 35 Sheep, meat byproducts 0.200000 1.000 1.000 max res

3500341000 35 Sheep, fat 0.005000 1.000 1.000 max res

3500341001 35 Sheep, fat-babyfood 0.005000 1.000 1.000 max res

3500342000 35 Sheep, kidney 0.200000 1.000 1.000 max res

3500343000 35 Sheep, liver 0.070000 1.000 1.000 max res

3600222000 36 Milk, fat 0.010000 1.000 1.000 PDP/max res

3600222001 36 Milk, fat-baby food/infant formu 0.010000 1.000 1.000 PDP/max res

3600223000 36 Milk, nonfat solids 0.010000 1.000 1.000 PDP/max res

3600223001 36 Milk, nonfat solids-baby food/in 0.010000 1.000 1.000 PDP/max res

3600224000 36 Milk, water 0.010000 1.000 1.000 PDP/max res

3600224001 36 Milk, water-babyfood/infant form 0.010000 1.000 1.000 PDP/max res

3600225001 36 Milk, sugar (lactose)-baby food/ 0.010000 1.000 1.000 PDP/max res

3800221000 38 Meat, game 0.001000 1.000 1.000 max res

3900312000 39 Rabbit, meat 0.001000 1.000 1.000 max res

8601000000 86A Water, direct, all sources 0.003800 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.003800 1.000 1.000 

9500020000 O Avocado 0.001500 1.800 1.000 1.8x for benzimidazole

9500023000 O Banana 3.000000 1.000 1.000 3 

9500023001 O Banana-babyfood 3.000000 1.000 1.000 3 

9500024000 O Banana, dried 0.028000 3.900 1.000 

9500024001 O Banana, dried-babyfood 0.028000 3.900 1.000 

9500215000 O Mango 10.000000 1.000 1.000 13 

9500215001 O Mango-babyfood 10.000000 1.000 1.000 13 

9500216000 O Mango, dried 10.000000 1.000 1.000 13 

9500217000 O Mango, juice 10.000000 1.000 1.000 13 

9500217001 O Mango, juice-babyfood 10.000000 1.000 1.000 13 

9500245000 O Papaya 5.000000 1.000 1.000 15 

9500245001 O Papaya-babyfood 5.000000 1.000 1.000 15 

9500246000 O Papaya, dried 0.080800 1.800 1.000 

9500247000 O Papaya, juice 5.000000 1.500 1.000 15 

9500283000 O Plantain 3.000000 1.000 1.000 3 

9500284000 O Plantain, dried 0.028000 3.900 1.000 
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 39 of 47

Attachment 4. Acute Results file - Food and Drinking Water

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID ACUTE Analysis for THIABENDAZOLE NHANES 2003-2008 2-Day

Residue file: 060101ACUTEThiabendazole 3 7 14.R08 Adjustment factor #2 used.

Analysis Date: 03-07-2014/12:42:53 Residue file dated: 03-07-2014/12:26:09

NOEL (Acute) = 50.000000 mg/kg body-wt/day

RAC/FF intake summed over 24 hours

MC iterations = 1000; MC list in residue file; MC seed = 1024; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

--- 95th Percentile---- --- 99th Percentile---- ---99.9th Percentile----

Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

Total US Population:

 0.001294 2.59 38626 0.003914 7.83 12773 0.012953 25.91 3860 

All Infants:

 0.002214 4.43 22585 0.006619 13.24 7554 0.021098 42.20 2369 

Children 1-2:

 0.004926 9.85 10150 0.013111 26.22 3813 0.034322 68.64 1456 

Children 3-5:

 0.003511 7.02 14241 0.010199 20.40 4902 0.028211 56.42 1772 

Children 6-12:

 0.001839 3.68 27187 0.006027 12.05 8296 0.017865 35.73 2798 

Youth 13-19:

 0.000866 1.73 57708 0.003082 6.16 16222 0.009042 18.08 5530 

Adults 20-49:

 0.000825 1.65 60631 0.002575 5.15 19418 0.007528 15.06 6641 

Adults 50-99:

 0.000896 1.79 55792 0.002775 5.55 18016 0.007786 15.57 6421 

Female 13-49:

 0.000805 1.61 62083 0.002638 5.28 18952 0.007789 15.58 6419 
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 40 of 47

Attachment 5. Acute Results file - Food Only

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID ACUTE Analysis for THIABENDAZOLE NHANES 2003-2008 2-Day

Residue file: 060101ACUTEThiabendazole FOOD ONLY 3 7 14.R08 Adjustment factor #2 used.

Analysis Date: 03-07-2014/12:54:14 Residue file dated: 03-07-2014/12:27:50

NOEL (Acute) = 50.000000 mg/kg body-wt/day

RAC/FF intake summed over 24 hours

MC iterations = 1000; MC list in residue file; MC seed = 1024; RNG = MS VB

Run Comment: ""

===============================================================================

Summary calculations--per capita:

--- 95th Percentile---- --- 99th Percentile---- ---99.9th Percentile----

Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

Total US Population:

 0.001186 2.37 42143 0.003811 7.62 13118 0.012887 25.77 3879 

All Infants:

 0.002001 4.00 24981 0.006324 12.65 7906 0.020320 40.64 2460 

Children 1-2:

 0.004785 9.57 10449 0.013011 26.02 3842 0.034871 69.74 1433 

Children 3-5:

 0.003431 6.86 14572 0.010007 20.01 4996 0.027754 55.51 1801 

Children 6-12:

 0.001753 3.51 28528 0.005944 11.89 8411 0.017764 35.53 2814 

Youth 13-19:

 0.000785 1.57 63656 0.002997 5.99 16680 0.008911 17.82 5611 

Adults 20-49:

 0.000706 1.41 70803 0.002457 4.91 20352 0.007495 14.99 6670 

Adults 50-99:

 0.000804 1.61 62190 0.002679 5.36 18663 0.007787 15.57 6421 

Female 13-49:

 0.000689 1.38 72590 0.002514 5.03 19888 0.007705 15.41 6489 
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 41 of 47

Attachment 6. CEC for Most Highly Exposed Population Subgroup (Children 1-2 years) file

U.S. EPA

DEEM-FCID Acute Critical Exposure Contribution Analysis (Ver. 3.16, 03-08-d)

NHANES 2003-2008 2-Day

Residue file = 060101ACUTEThiabendazole 3 7 14.R08

Acute report = acute 3 7 14.AC8

Date and time of analysis: 03-07-2014 12:35:30

Daily totals for food and foodform consumption used.

Adjustment factor #2 used.

Minimum exposure contribution = 5%

MC Iterations = 1000 Seed = 1024 RNG = MS VB

Exposures divided by body weight

Subpopulation:Children 1-2

Low percentile for CEC records: 99 Exposure (mg/day) = 0.013111

High percentile for CEC records: 99.9 Exposure (mg/day) = 0.034322

Number of actual records in this interval: 2594

Critical foods with foodforms for this population (as derived from these records):

 N=number of appearances in all records (including duplicates)

 %=percent of total exposure for all records (including duplicates)

Food FF N Percent Food Name 

---------- --- ----- ------- -------------

1100007000 110 1691 57.95% Apple, fruit with peel-Uncooked; Fresh or N/S; Cook Meth N/S

1100266000 110 445 14.26% Pear-Uncooked; Fresh or N/S; Cook Meth N/S

1100010000 110 355 9.03% Apple, juice-Uncooked; Fresh or N/S; Cook Meth N/S

1100267000 132 86 3.41% Pear, dried-Uncooked; Dried; Boiled

1100266000 240 81 1.86% Pear-Cooked; Canned; Cook Meth N/S

1100010001 240 53 1.60% Apple, juice-babyfood-Cooked; Canned; Cook Meth N/S

9500215000 110 44 1.35% Mango-Uncooked; Fresh or N/S; Cook Meth N/S

1100011000 212 41 0.86% Apple, sauce-Cooked; Fresh or N/S; Boiled

1100008001 240 24 0.66% Apple, peeled fruit-babyfood-Cooked; Canned; Cook Meth N/S

0103300000 212 22 0.52% Potato, tuber, w/o peel-Cooked; Fresh or N/S; Boiled

1100010000 240 23 0.37% Apple, juice-Cooked; Canned; Cook Meth N/S

9500217000 240 21 0.35% Mango, juice-Cooked; Canned; Cook Meth N/S

3600224000 110 155 0.33% Milk, water-Uncooked; Fresh or N/S; Cook Meth N/S

1100266000 210 22 0.32% Pear-Cooked; Fresh or N/S; Cook Meth N/S

2100228000 210 13 0.18% Mushroom-Cooked; Fresh or N/S; Cook Meth N/S

0103300000 223 12 0.17% Potato, tuber, w/o peel-Cooked; Frozen; Fried

1001240000 110 25 0.15% Orange-Uncooked; Fresh or N/S; Cook Meth N/S

9500023000 110 36 0.11% Banana-Uncooked; Fresh or N/S; Cook Meth N/S

9500023001 240 3 0.08% Banana-babyfood-Cooked; Canned; Cook Meth N/S

1100268001 240 4 0.07% Pear, juice-babyfood-Cooked; Canned; Cook Meth N/S

0103299000 211 3 0.07% Potato, tuber, w/peel-Cooked; Fresh or N/S; Baked

TRUNCATED
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 42 of 47

Attachment 7. Chronic Residue Input File

Filename: 060101CHRONICThiabendazole 3 7 14.R08

Chemical: Thiabendazole

RfD(Chronic): .033 mg/kg bw/day NOEL(Chronic): 10 mg/kg bw/day

RfD(Acute): .05 mg/kg bw/day NOEL(Acute): 50 mg/kg bw/day

Date created/last modified: 03-07-2014/12:30:50 Program ver. 3.16, 03-08-d

-----------------------------------------------------------------------------------

RDL indices and parameters for Monte Carlo Analysis:

Index Dist Parameter #1 Param #2 Param #3 Comment

 # Code 

----- ---- ------------ -------- -------- -------

 1 6 Apple Juice.rdf

 2 6 Apples.rdf

 3 6 Banana.rdf

 4 6 Cantaloupe.rdf

 5 6 Carrot.rdf

 6 6 Frozen Potato.rdf

 7 6 Potato.rdf

 8 6 Orange Juice.rdf

 9 6 Oranges.rdf

 10 6 Pears Baby Food.rdf

 11 6 Strawberry.rdf

 12 6 Sweet Potato.rdf

 13 6 Mango.rdf

 14 6 Mushrooms.rdf

 15 6 Papaya.rdf

 16 6 Wheat flour.rdf

 17 6 Apple Sauce.rdf

Note: No residue distributions have been assigned to Commodities/FoodForms below

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101050000 1AB Beet, garden, roots 0.020000 1.000 1.000 

0101050001 1AB Beet, garden, roots-babyfood 0.020000 1.000 1.000 

0101067000 1AB Burdock 0.020000 1.000 1.000 

0101078000 1AB Carrot 0.014900 1.000 1.000 

0101078001 1AB Carrot-babyfood 0.002000 1.000 1.000 

0101079000 1AB Carrot, juice 0.014900 1.000 1.000 

0101084000 1AB Celeriac 0.020000 1.000 1.000 

0101100000 1AB Chicory, roots 0.020000 1.000 1.000 

0101168000 1AB Ginseng, dried 0.020000 1.000 1.000 

0101190000 1AB Horseradish 0.020000 1.000 1.000 

0101250000 1AB Parsley, turnip rooted 0.020000 1.000 1.000 

0101251000 1AB Parsnip 0.020000 1.000 1.000 

0101251001 1AB Parsnip-babyfood 0.020000 1.000 1.000 

0101314000 1AB Radish, roots 0.020000 1.000 1.000 

0101316000 1AB Radish, Oriental, roots 0.020000 1.000 1.000 

0101327000 1AB Rutabaga 0.020000 1.000 1.000 

0101331000 1AB Salsify, roots 0.020000 1.000 1.000 

0101388000 1AB Turnip, roots 0.020000 1.000 1.000 

0103296000 1C Potato, chips 0.028900 1.000 1.000 Residues Do Not Concentrate

0103297000 1C Potato, dry (granules/ flakes) 0.028900 1.000 1.000 Residues Do Not Concentrate

0103297001 1C Potato, dry (granules/ flakes)-b 0.028900 1.000 1.000 Residues Do Not Concentrate

0103298000 1C Potato, flour 0.028900 1.000 1.000 Residues Do Not Concentrate

0103298001 1C Potato, flour-babyfood 0.028900 1.000 1.000 Residues Do Not Concentrate

0103299000 1C Potato, tuber, w/peel 0.028900 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.028900 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.028900 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.028900 1.000 1.000 

0103366000 1CD Sweet potato 0.005000 1.400 1.000 1.4x for benzimidazole

0103366001 1CD Sweet potato-babyfood 0.001500 1.400 1.000 1.4x for benzimidazole

0103406000 1CD Yam, true 0.005000 1.400 1.000 1.4x for benzimidazole

0301165000 3A Garlic, bulb 0.020000 1.000 1.000 

0301165001 3A Garlic, bulb-babyfood 0.020000 1.000 1.000 

0301237000 3A Onion, bulb 0.020000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 0.020000 1.000 1.000 

0301238000 3A Onion, bulb, dried 0.020000 1.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 0.020000 1.000 1.000 

0301338000 3A Shallot, bulb 0.020000 1.000 1.000 

0401355000 4A Spinach 0.020000 1.000 1.000 
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 43 of 47

0401355001 4A Spinach-babyfood 0.020000 1.000 1.000 

0501061000 5A Broccoli 0.020000 1.000 1.000 

0501061001 5A Broccoli-babyfood 0.020000 1.000 1.000 

0501062000 5A Broccoli, Chinese 0.020000 1.000 1.000 

0501064000 5A Brussels sprouts 0.020000 1.000 1.000 

0501069000 5A Cabbage 0.020000 1.000 1.000 

0501071000 5A Cabbage, Chinese, napa 0.020000 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 0.020000 1.000 1.000 

0501083000 5A Cauliflower 0.020000 1.000 1.000 

0501196000 5A Kohlrabi 0.020000 1.000 1.000 

0600347000 6 Soybean, seed 0.100000 1.000 0.010 Tol and blended commodity

0600349000 6 Soybean, soy milk 0.100000 1.000 0.010 Tol and blended commodity

0600349001 6 Soybean, soy milk-babyfood or in 0.100000 1.000 0.010 Tol and blended commodity

0600350000 6 Soybean, oil 0.100000 1.000 0.010 Tol and blended commodity

0600350001 6 Soybean, oil-babyfood 0.100000 1.000 0.010 Tol and blended commodity

0603030000 6C Bean, black, seed 0.100000 1.000 1.000 

0603032000 6C Bean, broad, seed 0.100000 1.000 1.000 

0603034000 6C Bean, cowpea, seed 0.100000 1.000 1.000 

0603035000 6C Bean, great northern, seed 0.100000 1.000 1.000 

0603036000 6C Bean, kidney, seed 0.100000 1.000 1.000 

0603038000 6C Bean, lima, seed 0.100000 1.000 1.000 

0603039000 6C Bean, mung, seed 0.100000 1.000 1.000 

0603040000 6C Bean, navy, seed 0.100000 1.000 1.000 

0603041000 6C Bean, pink, seed 0.100000 1.000 1.000 

0603042000 6C Bean, pinto, seed 0.100000 1.000 1.000 

0603098000 6C Chickpea, seed 0.100000 1.000 1.000 

0603098001 6C Chickpea, seed-babyfood 0.100000 1.000 1.000 

0603099000 6C Chickpea, flour 0.100000 1.000 1.000 

0603182000 6C Guar, seed 0.100000 1.000 1.000 

0603182001 6C Guar, seed-babyfood 0.100000 1.000 1.000 

0603203000 6C Lentil, seed 0.005000 1.000 1.000 

0603256000 6C Pea, dry 0.005000 1.000 1.000 

0603256001 6C Pea, dry-babyfood 0.005000 1.000 1.000 

0603258000 6C Pea, pigeon, seed 0.005000 1.000 1.000 

0603348000 6C Soybean, flour 0.100000 1.000 1.000 

0603348001 6C Soybean, flour-babyfood 0.100000 1.000 1.000 

0901075000 9A Cantaloupe 0.005200 1.800 1.000 1.8x for benzimidazole

0901187000 9A Honeydew melon 0.020000 1.000 1.000 

0901399000 9A Watermelon 0.020000 1.000 1.000 

0901400000 9A Watermelon, juice 0.020000 1.000 1.000 

0902021000 9B Balsam pear 0.020000 1.000 1.000 

0902088000 9B Chayote, fruit 0.020000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.020000 1.000 1.000 

0902135000 9B Cucumber 0.020000 1.000 1.000 

0902308000 9B Pumpkin 0.020000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.020000 1.000 1.000 

0902356000 9B Squash, summer 0.020000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.020000 1.000 1.000 

0902357000 9B Squash, winter 0.020000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.020000 1.000 1.000 

1001106000 10A Citron 0.030500 1.000 1.000 

1001107000 10A Citrus hybrids 0.030500 1.000 1.000 

1001108000 10A Citrus, oil 15.000000 1.000 1.000 

1001240000 10A Orange 0.030500 1.000 1.000 

1001241000 10A Orange, juice 0.015100 1.000 1.000 

1001241001 10A Orange, juice-babyfood 0.015100 1.000 1.000 

1001242000 10A Orange, peel 10.000000 3.300 1.000 Conc. for peel

1001369000 10A Tangerine 0.030500 1.000 1.000 

1001370000 10A Tangerine, juice 0.015100 1.000 1.000 

1002197000 10B Kumquat 0.030500 1.000 1.000 

1002199000 10B Lemon 0.030500 1.000 1.000 

1002200000 10B Lemon, juice 0.015100 1.000 1.000 

1002200001 10B Lemon, juice-babyfood 0.015100 1.000 1.000 

1002201000 10B Lemon, peel 10.000000 3.300 1.000 Conc. for peel

1002206000 10B Lime 0.030500 1.000 1.000 

1002207000 10B Lime, juice 0.015100 1.000 1.000 

1002207001 10B Lime, juice-babyfood 0.015100 1.000 1.000 

1003180000 10C Grapefruit 0.030500 1.000 1.000 

1003181000 10C Grapefruit, juice 0.015100 1.000 1.000 

1003307000 10C Pummelo 0.030500 1.000 1.000 

1100007000 11 Apple, fruit with peel 0.274100 1.000 1.000 

1100008000 11 Apple, peeled fruit 0.274100 1.000 1.000 

1100008001 11 Apple, peeled fruit-babyfood 0.274100 1.000 1.000 

1100009000 11 Apple, dried 0.274100 8.000 1.000 

1100009001 11 Apple, dried-babyfood 0.274100 8.000 1.000 
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 44 of 47

1100010000 11 Apple, juice 0.019100 1.000 1.000 

1100010001 11 Apple, juice-babyfood 0.019100 1.000 1.000 

1100011000 11 Apple, sauce 0.045800 1.000 1.000 

1100011001 11 Apple, sauce-babyfood 0.001500 1.000 1.000 

1100129000 11 Crabapple 0.274100 1.000 1.000 

1100173500 11 Goji berry 0.274100 1.000 1.000 

1100210000 11 Loquat 0.274100 1.000 1.000 

1100266000 11 Pear 0.274100 1.000 1.000 

1100266001 11 Pear-babyfood 0.006200 1.000 1.000 

1100267000 11 Pear, dried 0.274100 6.250 1.000 

1100268000 11 Pear, juice 0.019100 1.000 1.000 

1100268001 11 Pear, juice-babyfood 0.019100 1.000 1.000 

1100310000 11 Quince 0.274100 1.000 1.000 

1307359000 13G Strawberry 0.015100 1.800 1.000 1.8x for benzimidazole

1307359001 13G Strawberry-babyfood 0.015100 1.800 1.000 1.8x for benzimidazole

1307360000 13G Strawberry, juice 0.015100 1.800 1.000 1.8x for benzimidazole

1307360001 13G Strawberry, juice-babyfood 0.015100 1.800 1.000 1.8x for benzimidazole

1500025000 15 Barley, pearled barley 0.050000 1.000 1.000 

1500025001 15 Barley, pearled barley-babyfood 0.050000 1.000 1.000 

1500026000 15 Barley, flour 0.050000 1.000 1.000 

1500026001 15 Barley, flour-babyfood 0.050000 1.000 1.000 

1500027000 15 Barley, bran 0.050000 1.000 1.000 

1500120000 15 Corn, field, flour 0.005000 1.000 1.000 

1500120001 15 Corn, field, flour-babyfood 0.005000 1.000 1.000 

1500121000 15 Corn, field, meal 0.005000 1.000 1.000 

1500121001 15 Corn, field, meal-babyfood 0.005000 1.000 1.000 

1500122000 15 Corn, field, bran 0.005000 1.000 1.000 

1500123000 15 Corn, field, starch 0.005000 1.000 1.000 

1500123001 15 Corn, field, starch-babyfood 0.005000 1.000 1.000 

1500124000 15 Corn, field, syrup 0.005000 1.000 1.000 DESAC decision

1500124001 15 Corn, field, syrup-babyfood 0.005000 1.000 1.000 DESAC decision

1500125000 15 Corn, field, oil 0.005000 1.000 1.000 

1500125001 15 Corn, field, oil-babyfood 0.005000 1.000 1.000 

1500126000 15 Corn, pop 0.005000 1.000 1.000 

1500127000 15 Corn, sweet 0.005000 1.000 1.000 

1500127001 15 Corn, sweet-babyfood 0.005000 1.000 1.000 

1500231000 15 Oat, bran 0.050000 1.000 1.000 

1500232000 15 Oat, flour 0.050000 1.000 1.000 

1500232001 15 Oat, flour-babyfood 0.050000 1.000 1.000 

1500233000 15 Oat, groats/rolled oats 0.050000 1.000 1.000 

1500233001 15 Oat, groats/rolled oats-babyfood 0.050000 1.000 1.000 

1500328000 15 Rye, grain 0.050000 1.000 1.000 

1500329000 15 Rye, flour 0.050000 1.000 1.000 

1500381000 15 Triticale, flour 0.050000 1.000 1.000 

1500381001 15 Triticale, flour-babyfood 0.050000 1.000 1.000 

1500401000 15 Wheat, grain 0.050000 1.000 0.010 max res and blended commodity

1500401001 15 Wheat, grain-babyfood 0.050000 1.000 0.010 max res and blended commodity

1500402000 15 Wheat, flour 0.050000 1.000 0.010 max res and blended commodity

1500402001 15 Wheat, flour-babyfood 0.050000 1.000 0.010 max res and blended commodity

1500403000 15 Wheat, germ 0.050000 1.000 0.010 max res and blended commodity

1500404000 15 Wheat, bran 0.050000 1.000 0.010 max res and blended commodity

2100228000 21 Mushroom 0.183600 1.800 1.000 1.8x for benzimidazole

3100044000 31 Beef, meat 0.050000 1.000 1.000 FDA tol

3100044001 31 Beef, meat-babyfood 0.050000 1.000 1.000 FDA tol

3100045000 31 Beef, meat, dried 0.050000 1.920 1.000 FDA tol

3100046000 31 Beef, meat byproducts 0.200000 1.000 1.000 max res

3100046001 31 Beef, meat byproducts-babyfood 0.200000 1.000 1.000 max res

3100047000 31 Beef, fat 0.050000 1.000 1.000 FDA tol

3100047001 31 Beef, fat-babyfood 0.050000 1.000 1.000 FDA tol

3100048000 31 Beef, kidney 0.200000 1.000 1.000 max res

3100049000 31 Beef, liver 0.070000 1.000 1.000 max res

3100049001 31 Beef, liver-babyfood 0.070000 1.000 1.000 max res

3200169000 32 Goat, meat 0.001000 1.000 1.000 max res

3200170000 32 Goat, meat byproducts 0.200000 1.000 1.000 max res

3200171000 32 Goat, fat 0.005000 1.000 1.000 max res

3200172000 32 Goat, kidney 0.200000 1.000 1.000 max res

3200173000 32 Goat, liver 0.070000 1.000 1.000 max res

3300189000 33 Horse, meat 0.001000 1.000 1.000 max res

3400290000 34 Pork, meat 0.001000 1.000 1.000 max res

3400290001 34 Pork, meat-babyfood 0.001000 1.000 1.000 max res

3400291000 34 Pork, skin 0.005000 1.000 1.000 max res

3400292000 34 Pork, meat byproducts 0.200000 1.000 1.000 max res

3400292001 34 Pork, meat byproducts-babyfood 0.200000 1.000 1.000 max res

3400293000 34 Pork, fat 0.005000 1.000 1.000 max res

3400293001 34 Pork, fat-babyfood 0.005000 1.000 1.000 max res
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 45 of 47

3400294000 34 Pork, kidney 0.200000 1.000 1.000 max res

3400295000 34 Pork, liver 0.070000 1.000 1.000 max res

3500339000 35 Sheep, meat 0.001000 1.000 1.000 max res

3500339001 35 Sheep, meat-babyfood 0.001000 1.000 1.000 max res

3500340000 35 Sheep, meat byproducts 0.200000 1.000 1.000 max res

3500341000 35 Sheep, fat 0.005000 1.000 1.000 max res

3500341001 35 Sheep, fat-babyfood 0.005000 1.000 1.000 max res

3500342000 35 Sheep, kidney 0.200000 1.000 1.000 max res

3500343000 35 Sheep, liver 0.070000 1.000 1.000 max res

3600222000 36 Milk, fat 0.010000 1.000 1.000 PDP/max res

3600222001 36 Milk, fat-baby food/infant formu 0.010000 1.000 1.000 PDP/max res

3600223000 36 Milk, nonfat solids 0.010000 1.000 1.000 PDP/max res

3600223001 36 Milk, nonfat solids-baby food/in 0.010000 1.000 1.000 PDP/max res

3600224000 36 Milk, water 0.010000 1.000 1.000 PDP/max res

3600224001 36 Milk, water-babyfood/infant form 0.010000 1.000 1.000 PDP/max res

3600225001 36 Milk, sugar (lactose)-baby food/ 0.010000 1.000 1.000 PDP/max res

3800221000 38 Meat, game 0.001000 1.000 1.000 max res

3900312000 39 Rabbit, meat 0.001000 1.000 1.000 max res

8601000000 86A Water, direct, all sources 0.000470 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.000470 1.000 1.000 

9500020000 O Avocado 0.001500 1.800 1.000 1.8x for benzimidazole

9500023000 O Banana 0.028000 1.000 1.000 

9500023001 O Banana-babyfood 0.028000 1.000 1.000 

9500024000 O Banana, dried 0.028000 3.900 1.000 

9500024001 O Banana, dried-babyfood 0.028000 3.900 1.000 

9500215000 O Mango 0.077900 1.000 1.000 

9500215001 O Mango-babyfood 0.077900 1.000 1.000 

9500216000 O Mango, dried 0.077900 1.000 1.000 

9500217000 O Mango, juice 0.077900 1.000 1.000 

9500217001 O Mango, juice-babyfood 0.077900 1.000 1.000 

9500245000 O Papaya 0.080800 1.000 1.000 

9500245001 O Papaya-babyfood 0.080800 1.000 1.000 

9500246000 O Papaya, dried 0.080800 1.800 1.000 

9500247000 O Papaya, juice 0.080800 1.500 1.000 

9500283000 O Plantain 0.028000 1.000 1.000 

9500284000 O Plantain, dried 0.028000 3.900 1.000 
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 46 of 47

Attachment 8. Chronic Results File

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for THIABENDAZOLE NHANES 2003-2008 2-day

Residue file name: 060101CHRONICThiabendazole 3 7 14.R08

 Adjustment factor #2 used.

Analysis Date 03-07-2014/12:55:32 Residue file dated: 03-07-2014/12:30:50

Reference dose (RfD, Chronic) = .033 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.000379 1.1%

Hispanic 0.000499 1.5%

Non-Hisp-White 0.000359 1.1%

Non-Hisp-Black 0.000321 1.0%

Non-Hisp-Other 0.000468 1.4%

Nursing Infants 0.000371 1.1%

Non-Nursing Infants 0.000720 2.2%

Female 13+ PREG 0.000329 1.0%

Children 1-6 0.001223 3.7%

Children 7-12 0.000542 1.6%

Male 13-19 0.000315 1.0%

Female 13-19/NP 0.000276 0.8%

Male 20+ 0.000281 0.9%

Female 20+/NP 0.000259 0.8%

Seniors 55+ 0.000277 0.8%

All Infants 0.000612 1.9%

Female 13-50 0.000256 0.8%

Children 1-2 0.001562 4.7%

Children 3-5 0.001081 3.3%

Children 6-12 0.000597 1.8%

Youth 13-19 0.000295 0.9%

Adults 20-49 0.000267 0.8%

Adults 50-99 0.000276 0.8%

Female 13-49 0.000256 0.8%

-------------------------------------------------------------------------------
Thiabendazole (060101) Dietary Exposure and Risk Assessment DP Number: D416470

Page 47 of 47

Attachment 9. Screening Level Usage Analysis (SLUA) for Thiabendazole (060101)

SLUA for Thiabendazole

February 22, 2013 

(Reporting Timeframe: 2004-2011)

Percent Crop Treated

Crop Lbs. A.I. Average Maximum

1 Potatoes – seed treatment <500 <1 <2.5

2 Soybeans – seed treatment <500 <1 <2.5

3 Wheat – seed treatment <500 <1 <2.5

All numbers rounded.

<500 Less than 500 Lbs of active ingredient

<2.5 Less than 2.5 percent of crop treated

<1 Less than 1 percent of crop treated

SLUA data sources include: 

USDA-NASS (United States Department of Agriculture's National Agricultural Statistics Service) 

Private Pesticide Market Research

These results reflect amalgamated data developed by the Agency and are releasable to the public.