[Federal Register Volume 88, Number 167 (Wednesday, August 30, 2023)]
[Notices]
[Pages 59927-59928]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2023-18730]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Agency for Toxic Substances and Disease Registry

[Docket No. ATSDR-2023-0004]


Availability of Five Draft Toxicological Profiles and One Draft 
Interaction Profile

AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR), 
Department of Health and Human Services (HHS).

ACTION: Notice with comment period.

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SUMMARY: The Agency for Toxic Substances and Disease Registry (ATSDR), 
within the Department of Health and Human Services (HHS), announces the 
opening of a docket to obtain comments on drafts of five updated 
toxicological profiles, and one draft interaction profile: Creosote, 
Nickel, 1,2-Dichloroethene, Vinyl acetate, Acrylonitrile, and the 
Interaction Profile for Selected Metallic Ions. This action is 
necessary as this is the opportunity for members of the public and 
organizations to submit comments on drafts of the profiles. The 
intended effect of this action is to ensure that the public can note 
any pertinent additional information or reports on studies about the 
health effects of these six profiles for review.

DATES: Written comments must be received on or before November 28, 
2023.

ADDRESSES: You may submit comments, identified by Docket No. ATSDR-
2023-0004 by either of the methods listed below. Do not submit comments 
by email. ATSDR does not accept comments by email.
    <bullet> Federal eRulemaking Portal: http://www.regulations.gov. 
Follow the instructions for submitting comments.
    <bullet> Mail: Agency for Toxic Substances and Disease Registry, 
Office of Innovation and Analytics, 4770 Buford Highway, Mail Stop 
S106-5, Atlanta, GA 30341-3717. Attn: Docket No. ATSDR-2023-0004.
    Instructions: All submissions received must include the agency name 
and Docket Number. All relevant comments received will be posted 
without change to http://www.regulations.gov, including any personal 
information provided. For access to the docket to read background 
documents or comments received, go to http://www.regulations.gov.

FOR FURTHER INFORMATION CONTACT: Farhana Rahman, Agency for Toxic 
Substances and Disease Registry, Office of Innovation and Analytics, 
1600 Clifton Rd. NE, Mail Stop S106-5, Atlanta, GA 30329-4027; Email: 
<a href="/cdn-cgi/l/email-protection#9bdacfc8dfc9cff4e3cbe9f4fdf2f7feddc9d5e8dbf8fff8b5fcf4ed"><span class="__cf_email__" data-cfemail="e2a3b6b1a6b0b68d9ab2908d848b8e87a4b0ac91a2818681cc858d94">[email protected]</span></a>; Phone: 1-800-232-4636.

SUPPLEMENTARY INFORMATION: ATSDR has prepared drafts of five updated 
toxicological profiles and one interaction profile based on current 
understanding of the health effects and availability of new studies and 
other information since their initial release. All toxicological 
profiles issued as ``Drafts for Public Comment'' represent the result 
of ATSDR's evidence-based evaluations to provide important 
toxicological information on priority hazardous substances to the 
public and health professionals. ATSDR considers key studies for these 
substances during the profile development process, using a systematic 
review approach. To that end, ATSDR is seeking public comments and 
additional information or reports on studies about the health effects 
of these substances for review and potential inclusion in the profiles. 
ATSDR will evaluate the quality and relevance of such data or studies 
for possible inclusion in the profile.

Legislative Background

    The Superfund Amendments and Reauthorization Act of 1986 (SARA) [42 
U.S.C. 9601 et seq.] amended the Comprehensive Environmental Response, 
Compensation, and Liability Act of 1980 (CERCLA or Superfund) [42 
U.S.C. 9601 et seq.] by establishing certain requirements for ATSDR and 
the U.S. Environmental Protection Agency (EPA) regarding the hazardous 
substances most commonly found at facilities on the CERCLA National 
Priorities List. Among these statutory requirements is a mandate for 
the Administrator of ATSDR to prepare toxicological profiles for each 
substance included on the priority list of hazardous substances [also 
called the Substance Priority List (SPL)]. This list identifies 275 
hazardous substances that ATSDR has determined pose the most 
significant potential threat to human health. The SPL is available 
online at http://www.atsdr.cdc.gov/SPL. ATSDR is also mandated to 
revise and publish updated toxicological profiles, as necessary, to 
reflect updated health effects and other information.
    In addition, CERCLA provides ATSDR with the authority to prepare 
toxicological profiles for substances not found on the SPL. CERCLA 
authorizes ATSDR to establish and maintain an inventory of literature, 
research, and studies on the health effects of toxic substances (CERCLA 
Section 104(i)(1)(B); 42 U.S.C. 9604(i)(1)(B)); to respond to requests 
for health consultations (CERCLA Section 104(i)(4); 42 U.S.C. 
9604(i)(4)); and to support the site-specific response actions 
conducted by the agency (CERCLA Section 104(i)(6); 42 U.S.C. 
9604(i)(6)).
    ATSDR has now prepared drafts of five updated toxicological 
profiles, and one interaction profile based on current understanding of 
the health effects and availability of new studies and other 
information since their initial release.

Availability

    The draft toxicological profiles and interaction profile are 
available online at http://www.regulations.gov, Docket No. ATSDR-2023-
0004 and at http://www.atsdr.cdc.gov/ToxProfiles.

Public Participation

    Interested persons or organizations are invited to participate by 
submitting written views, recommendations, and data. Please note that 
comments received, including attachments and other supporting 
materials, are part of the public record and are subject to public 
disclosure. Comments will be posted on https://www.regulations.gov. 
Therefore, do not include any information in your comment or supporting 
materials that you consider confidential or inappropriate for public 
disclosure. If you include your name, contact information, or other 
information that identifies you in the body of your comments, that 
information will be on public display. ATSDR will review all 
submissions and may choose to redact, or withhold, submissions 
containing private or proprietary information such as Social Security 
numbers, medical information, inappropriate language, or duplicate/near 
duplicate examples of a mass-mail

[[Page 59928]]

campaign. Do not submit comments by email. ATSDR does not accept 
comments by email.

Donata Green,
Acting Associate Director, Office of Policy, Planning and Partnerships, 
Agency for Toxic Substances and Disease Registry.
[FR Doc. 2023-18730 Filed 8-29-23; 8:45 am]
BILLING CODE 4163-70-P


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