QuickLinks
 -- Click here to rapidly navigate through this document
  



Exhibit 4.3  


 
  AMENDMENT NO. 1 TO
  AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT    
    


        THIS AMENDMENT NO. 1 TO AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (the
"Amendment") is made and entered into as of this            day of April, 2004, by and among FAVRILLE,
INC., a Delaware corporation (the "Company"), and the investors listed on  Schedule A attached hereto (each of which is
referred to herein as an "Investor" and all of which
are collectively referred to herein as the "Investors"). 


 
 

RECITALS    
    


        WHEREAS, concurrently herewith, the Company and certain of the Investors have entered into that certain Amendment
No. 1 to Series C Preferred Stock Purchase Agreement (the "Purchase Amendment") pursuant to which the Company is selling and issuing, and
the New Investors (as defined in the Purchase Amendment) are purchasing, an aggregate of                        shares of the
Company's Series C Preferred Stock, par value $0.001 per share (the
"Additional Shares"); 


        WHEREAS, the Company and the Investors (other than the New Investors) are parties to that certain Amended and Restated Investor Rights
Agreement dated March 26, 2004 (the "Investor Rights Agreement"). Any capitalized term used in this Amendment and not defined herein shall have
the meaning assigned to such term in the Investor Rights Agreement; 


        WHEREAS, Section 3.7 of the Investor Rights Agreement provides that the Investor Rights Agreement may be amended only with the
written consent of (i) the Company, (ii) the holders of a majority of the Registrable Securities then outstanding, (iii) the holders of 662/3% of the
Series A Stock then outstanding, (iv) the holders of 662/3% of the Series B Stock and the Series B-2 Stock then outstanding, voting together as a
single class, and (v) the holders of 51% of the Series C Stock then outstanding; and 



        WHEREAS, in connection with the consummation of the transactions contemplated by the Purchase Amendment, the parties to the Investor
Rights Agreement wish to amend the Investor Rights Agreement to cause each of the New Investors to become a party to the Investor Rights Agreement. 


 
 

AGREEMENT    
    


        NOW THEREFORE, in consideration of the foregoing promises and the mutual covenants set forth herein, the Company
and the Investors agree as follows: 


1.     AMENDMENT OF INVESTOR RIGHTS AGREEMENT.  


        (a)   Effective as of the Second Closing Date (as defined in the Purchase Amendment), each of the New Investors shall become a
party to the Investor Rights Agreement and shall be deemed both an "Investor" and a "Holder" for purposes of the Investor Rights Agreement, and the shares of Series C Stock purchased by such
New Investors shall be deemed "Registrable Securities" for purposes of the Investor Rights Agreement. 



        (b)   The Company and the Investors hereby agree that the provisions of Section 2.5 of the Investor Rights Agreement
shall not apply to the offer or sale of the Additional Shares to the New Investors. 


2.    COUNTERPARTS.    This Amendment may be executed in any number of counterparts,
each of which shall be an original, but all of which together shall constitute one instrument. 


3.    NO OTHER CHANGES.    Except as otherwise provided herein, all the terms and
conditions of the Agreement which are not inconsistent herewith shall remain in full force and effect and shall apply equally to this Amendment. 


[THE
REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK] 


1








        IN WITNESS WHEREOF, the parties hereto have executed this AMENDMENT NO. 1 TO AMENDED AND RESTATED INVESTOR
RIGHTS AGREEMENTas of the date set forth in the first paragraph hereof. 



	 	FAVRILLE, INC.
	

 	

By:	

 	

 
	 	 	/s/  JOHN P. LONGENECKER      
 John P. Longenecker

President and Chief Executive Officer
	

 	

Address:	

10421 Pacific Center Court Suite 150 San Diego, CA 92121
	 	Fax:	(858) 526-8000
	

 	
INVESTORS:
	

 	
WILLIAM BLAIR CAPITAL PARTNERS VII, L.P.
	

 	

By:	

William Blair Capital Management VII, L.P.

Its: General Partner
	

 	

By:	

William Blair Capital Management VII, L.L.C.
	 	Its:	General Partner
	

 	

By:	

 	

 
	 	 	/s/  A.M. MINOCHERHOMJEE      

	 	Name:	Arda Minocherhomjee
	 	Its:	Managing Director
	

 	

Address:	

227 West Monroe Street

Suite 3500

Chicago, Illinois 60606
	

 	

Fax:	

(312) 236-5782




[SIGNATURE
PAGE TO AMENDMENT NO. 1 TO

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 







	 	WILLIAM BLAIR CAPITAL PARTNERS VII QP, L.P.
	

 	

By:	

William Blair Capital Management VII, L.P.
	 	Its:	General Partner
	

 	

By:	

William Blair Capital Management VII, L.L.C.
	 	Its:	General Partner
	

 	

By:	

 	

 
	 	 	/s/  A.M. MINOCHERHOMJEE      

	 	Name:	Arda Minocherhomjee
	 	Its:	Managing Director
	

 	

Address:	

227 West Monroe Street

Suite 3500

Chicago, Illinois 60606
	 	Fax:	(312) 236-5782
	

 	
ALLOY PARTNERS 2000, L.P.

ALLOY VENTURES 2000, L.P.

ALLOY CORPORATE 2000, L.P.

ALLOY INVESTORS 2000, L.P.
	

 	

By:	

Alloy Ventures 2000, LLC
	 	Their:	General Partner
	

 	

/s/  DOUGLAS E. KELLY      
 Managing Member of Alloy Ventures 2000, LLC
	

 	

Address:	

480 Cowpers Street

2nd Floor

Palo Alto, CA 94301
	 	Fax:	(650) 687-5010




[SIGNATURE
PAGE TO AMENDMENT NO. 1 TO

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 







	 	ALLOY ANNEX I, L.P.
	

 	

By:	

Alloy Annex I, LLC
	 	Its:	General Partner
	

 	

/s/  DOUGLAS E. KELLY      
 Managing Member of Alloy Annex I, LLC
	

 	

Address:	

480 Cowpers Street, 2nd Floor

Palo Alto, CA 94301
	

 	
DE NOVO VENTURES I, LP

DE NOVO (Q) VENTURES I, LP
	

 	

By:	

De Novo Management LLC
	 	Their:	General Partner
	

 	

/s/  FRED DOTZLER      
 Fred Dotzler, Managing Director
	

 	

Address:	

1550 El Camino Real

Suite 150

Menlo Park, CA 94025
	 	Fax:	(650) 329-1315




[SIGNATURE
PAGE TO AMENDMENT NO. 1 TO

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 







	 	SANDERLING VENTURE PARTNERS V, L.P.

SANDERLING V BIOMEDICAL, L.P.

SANDERLING V LIMITED PARTNERSHIP

SANDERLING V BETEILIGUNGS GMBH & CO. KG

SANDERLING VENTURE PARTNERS V CO-INVESTMENT FUND, L.P.

SANDERLING V BIOMEDICAL CO-INVESTMENT FUND, L.P.
	

 	

By:	

Middleton, McNeil & Mills Associates V, LLC
	

 	

/s/  FRED MIDDLETON      
 Fred A. Middleton

Managing Director
	

 	

Address:	

400 South El Camino Real

Suite 1200

San Mateo, CA 94402
	 	Fax:	(650) 375-7077
	

 	
SANDERLING V VENTURES MANAGEMENT
	

 	

/s/  FRED MIDDLETON      
 Fred A. Middleton

Owner
	

 	

Address:	

400 South El Camino Real

Suite 1200

San Mateo, CA 94402
	 	Fax:	(650) 375-7077




[SIGNATURE
PAGE TO AMENDMENT NO. 1 TO

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 







	 	FORWARD VENTURES III INSTITUTIONAL PARTNERS L.P.
	

 	

By:	

Forward III Associates, LLC
	

 	

By:	

 	

 
	 	 	/s/  IVOR ROYSTON      

	 	Name:	 	 
	 	 	Ivor Royston, M.D.

	 	Title:	 	 
	 	 	Managing Member

	

 	

Address:	

9393 Towne Centre Drive

Suite 200

San Diego, CA 92121
	 	Fax:	(858) 452-8799
	

 	
FORWARD VENTURES III L.P.
	

 	

By:	

Forward III Associates, LLC
	

 	

By:	

 	

 
	 	 	/s/  IVOR ROYSTON      

	 	Name:	 	 
	 	 	Ivor Royston, M.D.

	 	Title:	 	 
	 	 	Managing Member

	

 	

Address:	

9393 Towne Centre Drive

Suite 200

San Diego, CA 92121
	 	Fax:	(858) 452-8799
	

 	
FORWARD VENTURES IV B L.P.
	

 	

By:	

Forward IV Associates, LLC
	

 	

By:	

 	

 
	 	 	/s/  IVOR ROYSTON      

	 	Name:	 	 
	 	 	Ivor Royston, M.D.

	 	Title:	 	 
	 	 	Managing Member

	

 	

Address:	

9393 Towne Centre Drive

Suite 200

San Diego, CA 92121
	 	Fax:	(858) 452-8799




[SIGNATURE
PAGE TO AMENDMENT NO. 1 TO

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 







	 	FORWARD VENTURES IV L.P.
	

 	

By:	

Forward IV Associates, LLC
	

 	

By:	

 	

 
	 	 	/s/  IVOR ROYSTON      

	 	Name:	 	 
	 	 	Ivor Royston, M.D.

	 	Title:	 	 
	 	 	Managing Member

	

 	

Address:	

9393 Towne Centre Drive

Suite 200

San Diego, CA 92121
	 	Fax:	(858) 452-8799
	

 	
JACOBS INVESTMENT COMPANY, LLC
	

 	

By:	

 	

 
	 	 	/s/  GARY E. JACOBS      

	 	Name:	 	 
	 	 	Gary E. Jacobs

	 	Title:	 	 
	 	 	Manager

	

 	

Address:	

13974 Boquito Drive

Del Mar, CA 92014
	

 	
STEPHEN J. KANDEL SSB ROTH CONVERSION IRA CUST.
	

 	

By:	

 	

 
	 	 	

	 	Name:	Stephen J. Kandel
	 	Title:	Beneficial Owner
	

 	

Address:	

1021 Muirlands Drive

La Jolla, CA 92037
	

 	

    
 SANDEN KANDEL
	

 	

Address:	

1021 Muirlands Drive

La Jolla, CA 92037




[SIGNATURE
PAGE TO AMENDMENT NO. 1 TO

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 







	 	EBR HOLDINGS II LTD.
	

 	

By:	

 	

 
	 	 	

	 	Name:	 	 
	 	 	

	 	Title:	 	 
	 	 	

	

 	

Address:	

3366 N. Torrey Pines Ct.

Suite 210

La Jolla, CA 92037
	

 	

    
 ELLIOT FEUERSTEIN
	

 	

Address:	

8588 Ruette Monte Carlo

La Jolla, CA 92037
	

 	
MICHAEL M. BERNS LIVING TRUST

DATED 10/16/90, MICHAEL M. BERNS,

TRUSTEE
	

 	

By:	

 	

 
	 	 	
 Michael M. Berns

Trustee
	

 	

Address:	

1617 Emerald Bay

Laguna Beach, CA 92651
	

 	
THE PAYNE FAMILY TRUST DATED 1/23/85, ERROL G. PAYNE AND NAOMI F. PAYNE, TRUSTEES
	

 	

By:	

 	

 
	 	 	
 Errol G. Payne and Naomi F. Payne

Trustees
	

 	

Address:	

21 Ritz Cove Drive

Dana Point, CA 92629




[SIGNATURE
PAGE TO AMENDMENT NO. 1 TO

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 







	

 	

    
 JOSHUA COHEN AND LITA COHEN
	

 	

Address:	

8010 Frost Street, Suite 408

San Diego, CA 92123
	

 	
MICHAEL S. GROSSMAN UBS IRA ROLLOVER DG87091-68
	

 	

By:	

 	

 
	 	 	/s/  MICHAEL S. GROSSMAN      

	 	Name:	Michael S. Grossman
	 	Title:	Owner
	

 	

Address:	

310 Forward Street

La Jolla, CA 92037
	

 	
MARGARET GROSSMAN UBS IRA DG44753
	

 	

By:	

 	

 
	 	 	/s/  MARGARET STEVENS GROSSMAN      

	 	Name:	Margaret Grossman
	 	Title:	Owner
	

 	

Address:	

310 Forward Street

La Jolla, CA 92037
	

 	

    
 GUILIO WASSMER
	

 	

Address:	

Schlyffistrasse 15

8806 Bäch

Switzerland
	

 	

/s/  CHRISTOPH DIETSCHE      
 CHRISTOPH DIETSCHE
	

 	

Address:	

Jurastrasse 27

CH-5000 Aarau

Switzerland




[SIGNATURE
PAGE TO AMENDMENT NO. 1 TO

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 







	 	WARNKE BROADLEY KENNEDY FAMILY TRUST DATED 3/29/89, JOSEPH F. KENNEDY, TRUSTEE, GERIANN WARNKE, TRUSTEE
	

 	

By:	

 	

 
	 	 	/s/  JOSEPH F. KENNEDY      

	 	Name:	Joseph F. Kennedy
	 	Title	Trustee
	

 	

Address:	

6390 Cardeno Drive

La Jolla, CA 92037
	

 	
IRA M. LECHNER & WINIFRED EILEEN HAAG FAMILY TRUST DATED 1/21/00: IRA M. LECHNER & WINIFRED EILEEN HAAG TRUSTEES
	

 	

By:	

 	

 
	 	 	/s/  IRA M. LECHNER      

	 	Name:	 	 
	 	 	Ira M. Lechner

	 	Title:	 	 
	 	 	Trustee

	

 	

Address:	

19811 4th Place

Escondido, CA 92029
	

 	
MORGAN STANLEY DW INC. CUSTODIAN FOR IRA M. LECHNER (MSDW TAX ID #94-1671384)
	

 	

By:	

 	

 
	 	 	/s/  IRA M. LECHNER      

	 	Name:	Ira M. Lechner
	 	Title:	Trustee
	

 	

Address:	

19811 4th Place

Escondido, CA 92029




[SIGNATURE
PAGE TO AMENDMENT NO. 1 TO

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 







	

 	

    
 NEVINS MCBRIDE
	

 	

Address:	

 
	 	 	 	

	

 	

 	

 	


	

 	
ALFRED AND ADELE SALEH FAMILY TRUST
	

 	

By:	

 	

 
	 	 	

	 	Name:	Fred Saleh
	 	Title:	 	 
	 	 	

	

 	

Address:	

14845 Caminito Lorren

Del Mar, CA 92014
	

 	

    
 LAWRENCE BIER
	

 	

Address:	

13 Blueberry Ridge Court

Rockville, MD 20854
	

 	
DENNIS FAMILY TRUST DATED 3/29/93, EDWARD A. DENNIS, TRUSTEE, MARTHA G. DENNIS, TRUSTEE
	

 	

By:	

 	

 
	 	 	/s/  EDWARD A. DENNIS,   

/s/  MARTHA G. DENNIS      
 Edward A. Dennis and

Martha G. Dennis

Trustees
	

 	

Address:	

1921 Hypatia Way

La Jolla, CA 92037
	

 	

/s/  ELLIOTT ROYSTON      
 ELLIOTT ROYSTON
	

 	

Address:	

1634 Ponce de Leon Ave., #207

Atlanta, GA 30307




[SIGNATURE
PAGE TO AMENDMENT NO. 1 TO

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 







	

 	

    
 DAVID W. ODMARK
	

 	

Address:	

 
	 	 	 	

	

 	

 	

 	


	

 	
INDOFIN, NV
	

 	

By:	

 	

 
	 	 	

	 	Name:	Pieter van Dongen
	 	Title:	Director
	

 	

Address:	

c/o Avobone S.A.

9, Place du Bourg-de-Four

1204 Geneva

Switzerland

1204
	

 	

    
 HOWARD ALTMANN
	

 	

Address:	

P.O. Box 1965

New York, NY 10013
	

 	
LOTUS BIOSCIENCE INVESTMENT HOLDINGS LIMITED
	

 	

By:	

 	

 
	 	 	

	 	Name:	Wong Ken Lum and

Mong Cheuk Wai
	 	Title:	Directors
	

 	

Address:	

9th Floor, Central Building

Pedder Street, Hong Kong




[SIGNATURE
PAGE TO AMENDMENT NO. 1 TO

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 







	

 	
MERCER REVOCABLE FAMILY TRUST DTD 7/13/89
	

 	

By:	

 	

 
	 	 	

	 	Name:	Thomas Mercer
	 	Title:	Trustee
	

 	

Address:	

P.O. Box 842

Rancho Santa Fe, CA 92067
	

 	
WEIL FAMILY TRUST OF 1980,

CHRISTOPHER WEIL AND PATRICIA WEIL
	

 	

By:	

 	

 
	 	 	/s/  CHRISTOPHER WEIL      

	 	Name:	Christopher Weil
	 	Title:	Trustee
	

 	

Address:	

12555 High Bluff Dr.

San Diego, CA 92130




[SIGNATURE
PAGE TO AMENDMENT NO. 1 TO

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 







	 	GC&H INVESTMENTS
	

 	

By:	

 	

 
	 	 	/s/  JOHN L. CARDOZA      

	 	Name:	John L. Cardoza
	 	Title:	Executive Partner
	

 	

Address:	

One Maritime Plaza

20th Floor

San Francisco, CA 94111
	

 	
GC&H INVESTMENTS, LLC
	

 	

By:	

 	

 
	 	 	/s/  JOHN L. CARDOZA      

	 	Name:	John L. Cardoza
	 	Title:	Executive Partner
	

 	

Address:	

One Maritime Plaza

20th Floor

San Francisco, CA 94111
	

 	
GRAY GHOST, LLC
	

 	

By:	

 	

 
	 	 	/s/  PHILIP GOELET      

	 	Name:	 	 
	 	 	Philip Goelet

	 	Title:	Manager
	

 	

Address:	

c/o Red Abbey, LLC

2330 West Joppa Road

Suite 330

Lutherville, MD 21093
	 	Fax:	(410) 494-4247




[SIGNATURE
PAGE TO AMENDMENT NO. 1 TO

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 







	 	HELLER FINANCIAL LEASING, INC.
	

 	

By:	

 	

 
	 	 	/s/  MARK KING      

	 	Name:	Mark King
	 	Title:	Sr. Vice President
	

 	

Address:	

500 W. Monroe Street

Chicago, IL 60661

Attn: GE Technology Finance—Portfolio Management
	 	Fax:	(312) 876-2593
	

 	
PRIVATE EQUITY HOLDING-FAVRILLE, L.L.C.
	

 	

By:	

Howard Hughes Medical Institute
	 	Its:	Sole Member and Manager
	

 	

By:	

 	

 
	 	 	/s/  MARK A. BARNARD      

	 	Name:	 	 
	 	 	Mark A. Barnard

	 	Title:	 	 
	 	 	Managing Director

	

 	

Address:	

4000 Jones Bridge Road

Chevy Chase, MD 20815
	 	Fax:	(301) 215-8691
	

 	
SFP BIOTECH PARTNERS
	

 	

By:	

 	

 
	 	 	/s/  STEVEN LEE YAMSHON      
 Steven Lee Yamshon

Managing Partner
	

 	

Address:	

1851 E. First Street #150

Santa Ana, CA 92705




[SIGNATURE
PAGE TO AMENDMENT NO. 1 TO

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 







	 	STEPHEN J. KANDEL SSB ROTH

CONVERSION IRA CUST.
	

 	

By:	

 	

 
	 	 	/s/  STEPHEN J. KANDEL      

	 	Name:	Stephen J. Kandel
	 	Title:	Beneficial Owner
	

 	

Address:	

1021 Muirlands Drive

La Jolla, CA 92037
	

 	

/s/  STEPHEN J. KANDEL      
 STEPHEN AND GENEVIEVE KANDEL
	

 	

Address:	

P.O. Box 1891

Rancho Santa Fe, CA 92067




[SIGNATURE
PAGE TO AMENDMENT NO. 1 TO

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 







	 	OAKWOOD MEDICAL MANAGEMENT IV (QP), L.L.C.
	

 	

By:	

Oakwood Medical Management IV, L.L.C.
	 	Its:	Manager
	

 	

By:	

 	

 
	 	 	

	 	Name:	Raul E. Perez, M.D.
	 	Title:	President
	

 	

Address:	

439 Kirkwood Road, Suite 208

St. Louis, Missouri 63122
	

 	

 	

 	

 
	 	OAKWOOD MEDICAL INVESTORS IV, L.L.C.
	

 	

By:	

Oakwood Medical Management IV, L.L.C.
	 	Its:	Manager
	

 	

By:	

 	

 
	 	 	

	 	Name:	Raul E. Perez, M.D.
	 	Title:	President
	

 	

Address:	

439 Kirkwood Road, Suite 208

St. Louis, Missouri 63122




[SIGNATURE
PAGE TO AMENDMENT NO. 1 TO

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 







	 	COMMUNITY INVESTMENT PARTNERS V L.P., LLLP
	

 	

By:	

CIP Management L.P., LLLP
	 	Its:	Managing General Partner
	

 	

By:	

 	

 
	 	 	

	 	Name:	Daniel A. Burkhardt
	 	Title:	Chairman of CIP Management, Inc., Managing General Partner of CIP Management L.P., LLLP
	

 	

Address:	

12555 Manchester Road

St. Louis, Missouri 63131
	

 	
PIPER JAFFRAY HEALTHCARE FUND IV, L.P.
	

 	

By:	

Piper Jaffray Healthcare Management IV, LLC
	 	Its:	General Partner
	

 	

By:	

 	

 
	 	 	/s/  HEATH LUKATCH      
 Heath Lukatch, Managing Director of Piper Jaffray Ventures Inc., its General
Partner
	

 	

Address:	

100 Spear Street, Suite 1600

San Francisco, CA 94105
	 	Fax:	(415) 979-9488




[SIGNATURE
PAGE TO AMENDMENT NO. 1 TO

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 







	 	AVTECH PORTFOLIO, L.P.
	

 	

By:	

AVTech Ventures II, LLC
	 	Its:	General Partner
	

 	

By:	

 	

 
	 	 	
 Gary L. Shields, Managing Member
	

 	

Address:	

1201 Camino Del Mar, Suite 215

Del Mar, CA 92014
	 	Fax:	(858) 356-3563
	

 	
MATTHEW C. & IRIS LYNN STRAUSS, CO-TRUSTEES OF STRAUSS FAMILY TRUST DTD. 6/5/92
	

 	

By:	

 	

 
	 	 	/s/  MATTHEW STRAUSS      

	 	Name:	Matthew C. Strauss
	 	Title	Co-Trustee
	

 	

Address:	

c/o MC Strauss Company

990 Highland Drive, Suite 200

Solana Beach, CA 92075
	 	Fax:	(858) 792-7834
	

 	
BOSTON LIFE SCIENCE VENTURE CORP.
	

 	

By:	

 	

 
	 	 	/s/  KENNETH LO      

	 	Name:	Kenneth C.M. Lo
	 	Title:	Chairman
	

 	

Address:	

5th Fl. No. 420

Fu-Hsin N. Road

Taipei, Taiwan




[SIGNATURE
PAGE TO AMENDMENT NO. 1 TO

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 







	

 	
THOMAS A. SHIFTAN AND MAUREEN E. SHIFTAN, CO-TRUSTEES OF SHIFTAN FAMILY TRUST DTD. 3/23/98
	

 	

By:	

 	

 
	 	 	/s/  THOMAS SHIFTAN      

	 	Name:	Thomas A. Shiftan
	 	Title	Co-Trustee
	

 	

Address:	

7040 Neptune Place

La Jolla, CA 92037




[SIGNATURE
PAGE TO AMENDMENT NO. 1 TO

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 







	 	NEEDHAM CAPITAL SBIC III, L.P.

NEEDHAM CAPITAL PARTNERS IIIA, L.P.

NEEDHAM CAPITAL PARTNERS III (BERMUDA), L.P.
	

 	

By:	

 	

 
	 	 	/s/  JOHN J. PRIOR, JR.      

	 	Name:	 	 
	 	 	John J. Prior, Jr.

	 	Title:	 	 
	 	 	General Partner

	

 	

Address:	

Needham Asset Management

445 Park Avenue

New York, NY 10022




[SIGNATURE
PAGE TO AMENDMENT NO. 1 TO

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 







	 	1998 CO-INVESTING LLC

EIN 43-1831139
	

 	

By:	

 	

 
	 	 	/s/  JEFFREY MCDONNELL      

	 	Name:	Jeff McDonnell
	 	Title	Title Manager
	

 	

Address:	

1034 S. Brentwood, Suite 1860

St. Louise, MO 63117
	

 	
SCHRODERS & CO. BANK SA
	

 	

By:	

 	

 
	 	 	/s/  SAMUEL MOULIN      

	 	Name:	 	 
	 	 	Samuel Moulin

	 	Title:	 	 
	 	 	Director

	

 	

Address:	

8, Rue D'Italie

Geneve, Switzerland




[SIGNATURE
PAGE TO AMENDMENT NO. 1 TO

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 







	

 	

/s/  ERIC W. ROBERTS      
 ERIC W. ROBERTS
	

 	

Address:	

205 E 78th St., #4H

New York, NY 10022
	

 	
SCHEIBLER-LEHENY FAMILY LIVING TRUST U/D/T JUNE 6, 2001
	

 	

By:	

 	

 
	 	 	/s/  EDWARD M. SCHEIBLER      

	

 	

By:	

 	

 
	 	 	/s/  A. RACHEL LEHENY      

	

 	

Names:	

Edward G. Scheibler, Trustee

A. Rachel Leheny, Trustee
	

 	

Address:	

 
	 	 	 	P.O. Box 647

	

 	

 	

 	

Rancho Santa Fe, CA 92067

	

 	

 	

 	


	

 	
THE NICHOLAS & PADDI ARTHUR TRUST DATED 4-14-98
	

 	

By:	

 	

 
	 	 	/s/  NICHOLAS ARTHUR      

	

 	

By:	

 	

 
	 	 	/s/  PADDI ARTHUR      

	

 	

Names:	

Nicholas Arthur, Co-Trustee

Paddi Arthur, Co-Trustee
	

 	

Address:	

 
	 	 	 	

	

 	

 	

 	


	

 	

 	

 	






[SIGNATURE
PAGE TO AMENDMENT NO. 1 TO

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT] 







 
 

SCHEDULE A    
    
    INVESTORS    
    


INVESTOR  


William
Blair Capital Partners VII, L.P. 


William
Blair Capital Partners VII QP, L.P. 


Alloy
Partners 2000, L.P. 


Alloy
Ventures 2000, L.P. 


Alloy
Corporate 2000, L.P. 


Alloy
Investors 2000, L.P. 


Alloy
Annex I, L.P. 


De
Novo Ventures I, LP 


De
Novo (Q) Ventures I, LP 


Sanderling
Venture Partners V, L.P. 


Sanderling
V Biomedical, L.P. 


Sanderling
V Limited Partnership 


Sanderling
V Beteiligungs GmbH & Co. KG 


Sanderling
V Ventures Management 


Sanderling
Venture Partners V Co-Investment Fund, L.P. 



Sanderling
V Biomedical Co-Investment Fund, L.P. 


Forward
Ventures III Institutional Partners L.P. 


Forward
Ventures III L.P. 


Forward
Ventures IV B L.P. 


Forward
Ventures IV L.P. 


Jacobs
Investment Company, LLC 


Stephen
J. Kandel SSB Roth Conversion IRA Cust. 


Sanden
Kandel 


EBR
Holdings II Ltd. 


Elliot
Feuerstein 


Michael
M. Berns Living Trust Dated 10/16/90, Michael M. Berns, Trustee 



The
Payne Family Trust Dated 1/23/85, Errol G. Payne and Naomi F. Payne, Trustees 


Joshua
Cohen and Lita Cohen 


Michael
S. Grossman UBS IRA Rollover DG87091-68 


Margaret
Grossman UBS IRA DG44753 


Guilio
Wassmer 


Christoph
Dietsche 








Warnke
Broadley Kennedy Family Trust Dated 3/29/89, Joseph F. Kennedy, Trustee, Geriann Warnke, Trustee 



Ira
M. Lechner & Winifred Eileen Haag Family Trust Dated 1/21/00: Ira M. Lechner & Winifred Eileen Haag Trustees 


Morgan
Stanley DW Inc. Custodian for Ira M. Lechner (MSDW Tax ID #94-1671384) 


Nevins
McBride 


Alfred
and Adele Saleh Family Trust 


Lawrence
Bier 


Dennis
Family Trust Dated 3/29/93, Edward A. Dennis, Trustee, Martha G. Dennis, Trustee 


Elliott
Royston 


David
W. Odmark 



Indofin,
NV 


Howard
Altmann 


Lotus
Bioscience Investment Holdings Limited 


Mercer
Revocable Family Trust DTD 7/13/89 


Weil
Family Trust of 1980, Christopher Weil and Patricia Weil 


GC&H
Investments 


GC&H
Investments, LLC 


Gray
Ghost, LLC 


Heller
Financial Leasing, Inc. 


SFP
Biotech Partners 


Schroders
& Co. Bank SA 



Antonio
J. Grillo-Lopez and Maria S. Grillo Trustees Grillo-Marxuach Family Trust dated 6-28-95 


Private
Equity Holding-Favrille, L.L.C. 


Stephen
Kandel CGM Roth Conversion IRA CUST A/C #119-51879-17-380 


Stephan
and Genevieve Kandel 


Oakwood
Medical Investors IV (QP), L.L.C. 


Oakwood
Medical Investors IV, L.L.C. 


Community
Investment Partners V L.P., LLLP 


Piper
Jaffray Healthcare Fund IV, L.P. 


AVTech
Portfolio, L.P. 


Matthew
C. & Iris Strauss, co-trustees of Strauss Family Trust dtd. 6/5/92 


Boston
Life Science Venture Corp. 


Thomas
A. Shiftan and Maureen E. Shiftan, co-trustees of Shiftan Family Trust dated 3/23/98 


[ADD NEW SERIES C INVESTORS]  











QuickLinks


AMENDMENT NO. 1 TO AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT

RECITALS

AGREEMENT



SCHEDULE A INVESTORS