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Exhibit 10.21.1

Compensatory Arrangements of Certain Officers

On February 27, 2007, the Compensation Committee of the Board of Directors (the "Committee") of Genzyme Corporation ("Genzyme") determined 2007 incentive
bonuses for Genzyme's named executive officers. Prior to the beginning of 2007, the Committee had established a bonus target for each named executive officer.

For
each of the named executive officers, the bonus target includes both a corporate performance component and an individual performance component, which components are weighted on an
individual basis. The corporate performance component is payable based on the extent to which Genzyme achieves the operating income goals approved by the Board of Directors in connection with setting
the 2007 annual budget. The current corporate performance bonus formula allows for 100% payment when 100% of the target is met. If the performance target is exceeded, for every 1% above the target,
2.5% is added to the bonus payment, up to a maximum of 150% payment for achievement of 120% or more of the target. If the performance target is not met, for every 1% below the target, 1.5% is reduced
from the bonus payment. No corporate bonus is paid if less than 86% of the target is met. For 2007, Genzyme exceeded the operating income goals by 12% and, in accordance with the formula, the
Committee awarded the corporate performance component at 130% of target. The Committee also evaluated the individual performance of each of the named executive officers. The Committee awarded to the
named executive officers the individual performance component at 90% to 105% of target. For 2007, the Committee awarded to the named executive officers aggregate total bonuses ranging from 120% to
124% of target.

The
2007 base salaries and incentive bonuses for Genzyme's named executive officers are listed below. Additional information regarding compensation of the Company's named executive
officers will be included in Genzyme's proxy statement to be filed in connection with its Annual Meeting of Shareholders to be held on May 22, 2008.

|Named Executive Officer                                            |  | 2007 Base Salary |           | 2007 Bonus
|------------------------------------------------------------------ |  | ---------------- | --------- | ----------
|Henri A. Termeer
Chief Executive Officer                           |  | $                | 1,505,000 |           
|Earl M. Collier, Jr.
Executive Vice President                      |  | $                | 537,000   |           
|Alan Smith
Senior Vice President & Chief Science Officer           |  | $                | 490,000   |           
|Peter Wirth
Executive Vice President; Chief Legal Officer          |  | $                | 706,000   |           
|Michael S. Wyzga
Executive Vice President; Chief Financial Officer |  | $                | 490,000   |           

---



QuickLinks
From: Laurel Roy

To: E-OHPSCA2713.EBSA

Subject: RIN 1210-AB44 Mandatory Birth Control

Date: Saturday, August 06, 2011 7:40:06 AM

To Whom it May Concern,

I object in the strongest of terms to mandating birth control with no co-pays under

the Affordable Care Act.

Birth control is already widely available to all women, subsidized largely by

taxpayers. Demanding that we further subsidize other people's birth control by

increasing our insurance premiums in these days when families are struggling just to

make ends meet is an outrage. 

The mandate violates my conscience and that of millions of Americans who oppose

birth control on moral and religious grounds. 

It is undisputed that one of the operations of contraceptives is to render the

endometrium hostile to implantation, so that if fertilization occurs, the newly

conceived child may be lost to an early abortion. I also strongly object to the

inclusion of free sterilization as well as abortifacient pills like ella, which can work

weeks after a person's biological beginning to cause an abortion.

And what of Catholic employers and others who oppose birth control, but are now

going to be forced to participate in these plans and/or offer it to their employees?

This flies in the face of the conscience protections that Americans have historically

enjoyed.

The conscience provisions attached to the rule are so narrowly crafted that they

would appear to force Catholic institutions to make free birth control and sterilization

available in health plans, or cease hiring and providing services to non-Catholics. 

It is incomprehensible that such a mandate is being forced upon the people of the

United States.

It is no secret that Planned Parenthood, the largest abortion chain in America, is

behind this mandate, and will reap huge financial benefits from it at a time when

citizens in the United States are working on both the state and federal levels to

defund the abortion giant. 

The majority of Americans are pro-life and we do not want our tax dollars and

insurance premiums supporting the nation's largest abortion chain.

It is imperative that you give credence to my personal objection along with those of

millions of other Americans who do not want to be forced to pay for and provide

medication, devices, and procedures that do not treat or prevent any disease or

illness, but distort and render inoperable a healthy reproductive system. This rule is

unjust, untenable, and un-American--and it should be stricken.

Sincerely,

Laurel Roy
Chelmsford, Massachusetts
[No. 2378.]

#### Crowe v. Walker et al.

Appellate Practice — Abstract of Record.

A judgment for services performed will not be reviewed where it does not appear from the evidence as disclosed by the abstract of record what amount of services was performed, for whom performed, nor their value.

*Error to the District Court of El Paso County.*

Mr. M. J. Galligan, for plaintiff in error.

Gunter, J.

This was an action by defendants in error to recover for services alleged to have been performed by themselves and their assignors on a certain mining claim. From a judgment in their favor the case is here.

We rule the ease upon the evidence as disclosed by the abstract. Neither the amount of the services performed, their value, nor for whom rendered, in any manner appears.

The judgment must be reversed.

Reversed.
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From: JoAnne Blair

To: E-OHPSCA2713.EBSA

Subject: Thank you for supporting birth control access for all women

Date: Tuesday, August 02, 2011 10:17:16 PM

Dear Kathleen Sebelius, Secretary of Health & Human Services,

I commend the Department of Health & Human Services' landmark decision requiring health insurers to

cover the full cost of contraception, with no co-pay, beginning in August 2012.

This policy places a much-needed importance on women's health that is too-often not a priority in

health care policy. Birth control is a critical part of preventive care, and making contraception available

to all women, regardless of their insurance or ability to pay for it, will significantly reduce long-term

health care costs associated with unplanned pregnancies.

Thank you for prioritizing women's basic health care needs.

Sincerely,

JoAnne Blair

1306 Willow Rd

West Palm Beach, FL 33406
EXHIBIT 32.1

McDATA Corporation

Certification

Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

(Subsections
(a) and (b) of Section 1350, Chapter 63 of Title 18, United States Code)

Pursuant to Section 906 of the Sarbanes-Oxley
Act of 2002 (subsections (a) and (b) of Section 1350, Chapter 63 of Title 18,

United States Code), each of the undersigned
officers of McDATA Corporation, a Delaware corporation (the Company),

does hereby certify, to such officers knowledge,
that:

The Companys Annual Report on Form 10-K for the period ended January 31, 2006 (the Report) fully complies
with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended, and information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the
Company.



|                      |  |                                                                    
|--------------------- |  | -------------------------------------------------------------------
|Dated: April 24, 2006 |  | /s/ JOHN A. KELLEY, JR.                                            
|                      |  | John A. Kelley, Jr. Chairman, President and Chief Executive Officer
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Hosted by Defense Media Activity - WEB.mil
From: Kristin Walraven

To: E-OHPSCA2713.EBSA

Subject: RIN 1210-AB44 Mandatory Birth Control

Date: Friday, August 05, 2011 3:17:15 PM

To Whom it May Concern,

I object in the strongest of terms to mandating birth control with no co-pays under

the Affordable Care Act.

Birth control is already widely available to all women, subsidized largely by

taxpayers. Demanding that we further subsidize other people's birth control by

increasing our insurance premiums in these days when families are struggling just to

make ends meet is an outrage. 

The mandate violates my conscience and that of millions of Americans who oppose

birth control on moral and religious grounds. 

It is undisputed that one of the operations of contraceptives is to render the

endometrium hostile to implantation, so that if fertilization occurs, the newly

conceived child may be lost to an early abortion. I also strongly object to the

inclusion of free sterilization as well as abortifacient pills like ella, which can work

weeks after a person's biological beginning to cause an abortion.

And what of Catholic employers and others who oppose birth control, but are now

going to be forced to participate in these plans and/or offer it to their employees?

This flies in the face of the conscience protections that Americans have historically

enjoyed.

The conscience provisions attached to the rule are so narrowly crafted that they

would appear to force Catholic institutions to make free birth control and sterilization

available in health plans, or cease hiring and providing services to non-Catholics. 

It is incomprehensible that such a mandate is being forced upon the people of the

United States.

It is no secret that Planned Parenthood, the largest abortion chain in America, is

behind this mandate, and will reap huge financial benefits from it at a time when

citizens in the United States are working on both the state and federal levels to

defund the abortion giant. 

The majority of Americans are pro-life and we do not want our tax dollars and

insurance premiums supporting the nation's largest abortion chain.

It is imperative that you give credence to my personal objection along with those of

millions of other Americans who do not want to be forced to pay for and provide

medication, devices, and procedures that do not treat or prevent any disease or

illness, but distort and render inoperable a healthy reproductive system. This rule is

unjust, untenable, and un-American--and it should be stricken.

Sincerely,

Kristin Walraven
Ypsilanti, Michigan
From: Katherine Lynch

To: E-OHPSCA2713.EBSA

Subject: RIN 1210-AB44 Mandatory Birth Control

Date: Friday, August 05, 2011 3:54:19 PM

To Whom it May Concern,

I object in the strongest of terms to mandating birth control with no co-pays under

the Affordable Care Act.

Birth control is already widely available to all women, subsidized largely by

taxpayers. Demanding that we further subsidize other people's birth control by

increasing our insurance premiums in these days when families are struggling just to

make ends meet is an outrage. 

The mandate violates my conscience and that of millions of Americans who oppose

birth control on moral and religious grounds. 

It is undisputed that one of the operations of contraceptives is to render the

endometrium hostile to implantation, so that if fertilization occurs, the newly

conceived child may be lost to an early abortion. I also strongly object to the

inclusion of free sterilization as well as abortifacient pills like ella, which can work

weeks after a person's biological beginning to cause an abortion.

And what of Catholic employers and others who oppose birth control, but are now

going to be forced to participate in these plans and/or offer it to their employees?

This flies in the face of the conscience protections that Americans have historically

enjoyed.

The conscience provisions attached to the rule are so narrowly crafted that they

would appear to force Catholic institutions to make free birth control and sterilization

available in health plans, or cease hiring and providing services to non-Catholics. 

It is incomprehensible that such a mandate is being forced upon the people of the

United States.

It is no secret that Planned Parenthood, the largest abortion chain in America, is

behind this mandate, and will reap huge financial benefits from it at a time when

citizens in the United States are working on both the state and federal levels to

defund the abortion giant. 

The majority of Americans are pro-life and we do not want our tax dollars and

insurance premiums supporting the nation's largest abortion chain.

It is imperative that you give credence to my personal objection along with those of

millions of other Americans who do not want to be forced to pay for and provide

medication, devices, and procedures that do not treat or prevent any disease or

illness, but distort and render inoperable a healthy reproductive system. This rule is

unjust, untenable, and un-American--and it should be stricken.

Sincerely,

Katherine Lynch
Saline, Michigan
a)
    
    Designed such disclosure controls and procedures, or caused such disclosure
controls and procedures to be designed under our supervision, to ensure that material
information relating to the registrant, including its consolidated subsidiaries, is made
known to us by others within those entities, particularly during the period in which
this report is being prepared;b)
    
    Designed such internal control over financial reporting, or caused such internal
control over financial reporting to be designed under our supervision, to provide
reasonable assurance regarding the reliability of financial reporting and the
preparation of financial statements for external purposes in accordance with generally
accepted accounting principles;c)
    
    Evaluated the effectiveness of the registrants disclosure controls and
procedures and presented in this report our conclusions about the effectiveness of the
disclosure controls and procedures, as of the end of the period covered by this report
based on such evaluation; andd)
    
    Disclosed in this report any change in the registrants internal control over
financial reporting that occurred during the registrants most recent fiscal quarter
(the registrants fourth fiscal quarter in the case of an annual report) that has
materially affected, or is reasonably likely to materially affect, the registrants
internal control over financial reporting; and
  a)
    
    All significant deficiencies and material weaknesses in the design or operation
of internal control over financial reporting which are reasonably likely to adversely
affect the registrants ability to record, process, summarize and report financial
information; andb)
    
    Any fraud, whether or not material, that involves management or other employees
who have a significant role in the registrants internal control over financial
reporting.
  /s/ Stanley J. TalbiStanley J. TalbiExecutive Vice President and Chief Financial Officer
##### 



Exhibit 32.2 Certification of Chief Financial Officer
Pursuant to 18 U.S.C. Section 1350, as Adopted
Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 I, Randall D. Levy, Chief Financial Officer of Temple-Inland Inc., hereby certify pursuant to 18
U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that
this Annual Report on Form 10-K fully complies with the requirements of section 13(a) or 15(d) of
the Securities Exchange Act of 1934 and that the information contained in this Annual Report on
Form 10-K fairly presents, in all material respects, the financial condition and results of
operations of Temple-Inland Inc. /s/ Randall D. LevyRandall D. LevyMarch 9, 2005
From: Joline Gitis

To: E-OHPSCA2713.EBSA

Subject: Contraception coverage for ALL

Date: Wednesday, August 10, 2011 9:49:51 PM

I join with the American Association of University Women (AAUW) in asking you

to accept the recommendations of the Institute of Medicine as pertain to

coverage of preventive care under the new health care law, and to reject any

exemptions for “religious employers.” These preventive services are a critical

element of the new law and would provide countless women better access to

necessary health care.

While AAUW believes that “religious refusal” exemptions unjustly deny women

access to contraceptive services, others, driven by an ideological distaste for all

contraceptive services, are pushing the government to make exemptions even

larger. Indeed, some groups are pushing for the exemption to apply to

religiously-run health providers, so hospitals with religious affiliations would be

exempt from the coverage requirement, even though they employ people of all

faiths and ideologies. If granted, this larger exemption would deny access to

thousands of women just because of where they work.

I urge you to ensure women have access to quality preventive care by accepting

IOM’s recommendations and rejecting the proposed religious refusal exemption

provisions.