# Patent

## Title
Data processing, analysis method of gene expression data to identify endogenous reference genes

## Abstract

Disclosed are data processing and analysis methods for gene expression data for identifying endogenous reference genes and a composition for the quantitative analysis of gene expression, comprising a pair of primers and/or probes useful in amplifying the identified endogenous reference genes. Introduced with the concepts of “Zero's proportion” and CV, the method allows different datasets to be integrally analyzed, thereby searching for novel reference genes. By the method, 2,087 genes are first found as housekeeping genes which are expressed in most tissues, and the usefulness thereof in the relative quantification of different target genes is determined by analyzing their expression stability. Of the 2,087 genes, 13 genes show higher expression stability with lower expression levels across a wide range of samples than traditional reference genes such as GAPDH and ACTS, and therefore are suitable for the normalization of universal genes having relatively low expression levels.

## Background
RELATED APPLICATIONS
This application is a continuation of U.S. application Ser. No. 12/521,498, filed Jun. 26, 2009, which is the U.S. national phase pursuant to 35 U.S.C. §371, of PCT international application Ser. No. PCT/KR2007/006890, filed Dec. 27, 2007, designating the United States and published in English on Jul. 3, 2008 as publication WO 2008/078969 A1, which claims priority to Korean application Ser. No. 10-2006-0134883, filed Dec. 27, 2006. The entire contents of the aforementioned patent applications are incorporated herein by this reference.


SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on May 24, 2013, is named 84346-CON-301519_ST25.txt and is 8,058 bytes in size.
TECHNICAL FIELD
The present invention relates to a data processing and analysis method of gene expression data for identifying endogenous reference genes and a composition for the quantitative analysis of gene expression, comprising a pair of primers and/or probes useful in the amplification of the identified endogenous reference genes. More particularly, the present invention relates to a data processing and analysis method for identifying novel endogenous reference genes using gene expression data from EST, SAGE and microarray datasets with zero's proportion and coefficient of variation, and a composition for the quantitative analysis of gene expression, comprising a pair of primers and/or probes useful in the amplification of the identified endogenous reference genes.
BACKGROUND ART
As many as 50,000-100,000 genes can be found in each human cell, but are selectively used in each cell. Of them, a significant number of genes are involved in basic functions and routine cellular metabolic processes required for the sustenance of the cell. Such genes are called housekeeping genes (hereinafter referred to as “HKG”). In various gene expression analysis methods utilizing the quantification of messenger RNA (hereinafter referred to as “mRNA”) to determine expression levels of specific or multiple genes with the aim of identifying the functions of specific genes, searching for genes directed to specific functions, profiling the gene expression of organisms under specific conditions, and describing other biological purposes, endogenous reference genes mean housekeeping genes useful in the normalization of the mRNA level for the relative quantification of genes of interest.
Endogenous reference genes are most widely used to normalize mRNA level for accurate comparison of gene expression between different samples (Vandesompele J et al., Genome Biol 3(7), p. RESEARCH0034, 2002). Endogenous reference genes are usually used in gene expression analysis techniques ranging from conventional reverse transcriptase polymerase chain reaction (hereinafter referred to as “RT-PCR”) to recently developed quantitative real time PCR (hereinafter referred to as “qRT-PCT”), serial analysis of gene expression (hereinafter referred to as “SAGE”) and microarray. Traditional reference genes such as glyceraldehyde-3-phosphate dehydrogenase (hereinafter referred to as “GAPDH”) and β-actin (hereinafter referred to as “ACTB”) have been used without proper validation, assuming that they are expressed at constant levels across different samples, irrespectively cell or tissue type and are not regulated by experimental treatment.
However, it is well known that the expression of traditional reference genes may vary among different tissues and cell types and can be regulated by experimental conditions, including sample treatment, developmental stage and pathological states (Bereta J and Bereta M, Biochem Biophys Res Commun 217(1)363-369, 1995; Tricarico C et al., Anal Biochem 309(2):293-300, 2002; Thellin O et al., J Biotechnol 75(2-3):291-295, 1999; Rubie C et al., Mol Cell Probes 19(2):101-109, 2005; Schmittgen T D and Zakrajsek B A, J Biochem Biophys Methods 46(1-2):69-81, 2000; Zhong H and J Simons W, Biochem Biophys Res Commun 259(3):523-526, 1999; Selvey S et al., Mol Cell Probes 15(5):307-311, 2001; Wu Y Y and L Rees J, Acta Derm Venereol 80(1):2-3, 2000; Lee P D et al., Genome Res 12(2):292-297, 2002; Hamalainen H K et al., Anal Biochem 299(1):63-70, 2001). The use of inappropriate reference genes in the relative quantification of gene expression may result in biased expression profiles. This concern has already been raised by many researchers (Tricarico C et al., Anal Biochem 309(2):293-300 2002; Dheda K et al., Anal Biochem 344(1):141-143, 2005; de Kok J B et al., Lab Invest 85(1):154-159, 2005; Brunner A M et al., BMC Plant Biol 4:14, 2004). Particularly, the selection of proper endogenous reference genes is essential for accurate measurement in qRT-PCR, which is a reliable method for detecting gene expression with high sensitivity and accuracy though accurate normalization, and may not be required in qualitative analysis such as northern blot or conventional RT-PCR (Huggett J et al., Genes Immun 6(4):279-284, 2005).
With the acknowledgement of the importance of the proper validation of traditional reference genes and the identification of more suitable reference genes, a number of studies have been undertaken to select the most suitable genes among commonly used reference genes in specific experimental conditions, or to identify novel genes, which are superior to the traditional genes that are universally used for mRNA quantification. However, most of the previous studies have been focused on the selection (validation) of the most stable genes among commonly used reference genes in specific experimental systems or a given set of limited tissue samples (Goidin D et al., Anal Biochem 295(1):17-21, 2001; Haller F et al., Anal Biochem 335(1):1-9, 2004; Ohl F et al., J Mol Med 83(12):1014-1024, 2005; Radonic A et al., Biochem Biophys Res Commun 313(4):856-862, 2004). Some programs are now available for identifying the most appropriate genes among multiple reference genes using qRT-PCR results (Vandesompele J et al., Genome Biol 3(7), p. RESEARCH0034, 2002; Pfaffl M W et al., Biotechnol Lett 26(6):509-15, 2004; Andersen C L et al., Cancer Res 64(15):5245-5250, 2004).
In addition, novel endogenous reference genes have been found mostly on the basis of microarray data (Hamalainen H K et al., Anal Biochem 299(1):63-70, 2001; Hoerndli F J et al., Anal Biochem 335(1):30-41, 2004; Czechowski T et al., Plant Physiol 139(1):5-17, 2005; Jin P et al., BMC Genomics, 5(1):55, 2004; Kobayashi M S et al., J. Neurosci Res 76(4):512-518, 2004; Shulzhenko N et al., Biochem Biophys Res Commun 337(1):306-12, 2005). As is well-known, the microarray technique has some problems and limitations (errors) due to the potential for inaccurate cross hybridization between probes and unintended transcripts, the potential for differences in hybridization efficiency between probe sets, and the potential for the incorrect annotation of transcripts (Haverty P M et al., Bioinformatics 20(18):3431-3441, 2004; van Ruissen F et al., BMC Genomics 6:91, 2005). The microarray technique also allows the detection of expression of genes only on the chip, in contrast to expressed sequence tag (hereinafter referred to as “EST”) and SAGE, in which the expression profiles of whole transcripts in samples (cDNA libraries) can be measured (van Ruissen F et al., BMC Genomics 6:91, 2005). The use of gene expression data from different platforms together is expected to complement the limitation of individual platforms. For example, SAGE is far more sensitive than EST for detecting low-abundance transcripts (Sun M et al., BMC Genomics 5(1):1-4, 2004).
Even if an ideal endogenous reference gene does not exist, it is possible to find a more ideal endogenous reference gene applicable to most experimental conditions than traditional reference genes through various, large gene expression data.
Leading to the present invention, intensive and thorough research on accurate comparison of gene expression among different samples, conducted by the present inventors, resulted in the finding that gene expression datasets constructed from microarray data, in addition to EST and SAGE data, are useful in searching for endogenous reference genes, and that novel reference genes identified using the datasets are superior to previously used genes and show more stable expression across a wide range of samples, thus being universally useful for the normalization of gene expression, rather than being limited for use on specific tissue samples or in specific studies.
DISCLOSURE
Technical Problem
Therefore, it is an object of the present invention to provide a method of processing and analyzing gene expression data, with a statistical concept introduced thereinto, to identify endogenous reference genes which are superior to traditional reference genes in terms of expression stability across a wide range of samples, thus being universally useful for the normalization of gene expression, and a composition for the quantitative analysis of gene expression, comprising a pair of primers and/or probes useful in the amplification of the identified endogenous reference genes.
Technical Solution
In order to accomplish the above objects, the present invention provides a method for selecting candidate endogenous reference genes (ERG), comprising: 1) computing expression levels of genes from EST, SAGE and microarray datasets; and 2) identifying genes which are constitutively expressed across a wide range of tissues using the computed gene expression levels of step 1) and zero(0)'s proportions thereof.
Also, the present invention provides a composition for detecting at least one candidate endogenous reference gene selected according to the present invention, comprising a detection reagent applicable to amplification of the candidate endogenous reference gene.
Also, there is provided a method for quantifying an expression level of a gene of interest, comprising: 1) performing real-time PCR to amplify the gene of interest with a pair of primers and/or probes and then performing real-time PCR to amplify the a candidate endogenous reference gene with the composition; and 2) normalizing the expression level of the gene of interest relative to that of the candidate endogenous reference gene.
Furthermore, there is provided a method for selecting guide genes, comprising: measuring the candidate endogenous reference genes selected using the method for coefficient of variation (CV); and ranking the endogenous reference genes in an ascending order of CV.
Also, the present invention provides a composition for detecting at least one guide reference gene identified according to the present invention, comprising a detection reagent applicable to amplification of the guide gene.
There is provided a method for quantifying an expression level of a target gene, comprising: 1) synthesizing cDNA from RNA of a subject; 2) performing real-time PCR to amplify the target gene using a pair of primers and/or probes, with the cDNA serving as a template and then performing real-time PCR to amplify the candidate endogenous reference gene using the composition; and 3) normalizing an expression level of the target gene to that of the candidate endogenous reference gene of step 2).
Moreover, there is provided a method for identifying the amplification of a target gene in genomic DNA, comprising: 1) amplifying the target gene with a pair of primers or probes through real-time PCR, with a genomic DNA of a subject serving as a template and then performing real-time PCR to amplify the candidate endogenous reference gene with the composition; and 2) normalizing an expression level of the target gene to that of the candidate endogenous reference gene.
Advantageous Effects
Introduced with the concepts of ‘Zero's proportion’ and CV, the method of the present invention allows different datasets to be integrally analyzed, thereby searching for novel reference genes. By the method, 2,087 genes were first found as housekeeping genes which are expressed in most tissues, and the usefulness thereof in the relative quantification of different target genes was determined by analyzing their expression stability. Out of the 2,087 genes, 13 genes were found to show higher expression stability with lower expression levels across a wide range of samples than traditional reference genes such as GAPDH and ACTB, and therefore are suitable for the normalization of universal genes having relatively low expression levels.



DESCRIPTION OF DRAWINGS
FIG. 1 is a schematic view showing a process of identifying endogenous reference genes (ERGs).
FIG. 2 is a graph showing a functional distribution of candidate ERGs classified according to FunCat (Functional Classification Catalogue):
Numeral: numbers of genes
A: protein fate (folding, modification, destination); B: cellular transport, transport facilitation and transport route; C: transcription; D: cellular communication/signal transduction mechanism; E: cell cycle and DNA processing; F: protein synthesis; G: metabolism; H: energy; I: cell fate; J: interaction with cellular environment; K: interaction with environment (systemic); L: organ differentiation; M: development (systemic); N: protein activity regulation; O: tissue differentiation; P: biogenesis of cellular components; Q: cell rescue, defense and virulence; and R: cell type differentiation.
FIG. 3 shows correlations of gene expression of 2,087 candidates ERG among four datasets [EST (expressed sequence tag), ShortSAGE, LongSAGE and microarray datasets].
FIG. 4 shows correlations of CV (coefficient of variation %) of 2,087 candidates ERGs among four datasets (EST, ShortSAGE, LongSAGE and microarray datasets).
FIG. 5 is a graph showing the comparison of gene expression between the candidate ERGs, selected according to the present invention, and non-candidate ERGs among each dataset:
Box and Whisker plots: expression distribution expressed as natural log value (ln);
Bottom surface of box: corresponding to 25% of the total expression levels in ascending order; and
Top surface of box: corresponding to 75% of the total expression levels in ascending order.
FIG. 6 shows the comparison of gene expression between the 13 ERGs of the present invention and 13 arbitrarily selected traditional ERGs.
FIG. 7 shows the comparison of CV (%) between the 13 ERGs of the present invention and 13 arbitrarily selected traditional ERGs.
FIG. 8 is a graph showing mRNA level distributions of the novel and traditional ERGs, determined by, real-time PCR, in 48 samples including frozen human tissues and cancer cell lines.
FIG. 9 shows mRNA level distributions, expressed as Cp values determined using real-time PCR, of the novel and traditional ERGs in 48 samples (including frozen human tissues and cancer cell lines) and 60 FFPE (formalin-fixed paraffin-embedded) tissues. In the boxes, the middle lines represent median values of Cp, and the bottom and the top surfaces correspond to 25% and 75% of the total Cp values in ascending order, respectively.



BEST MODE
The terms used herein are defined before embodiments of the present invention are described in detail.
The term “candidate reference gene”, as used herein, is intended to refer to a gene, selected using the method of the present invention, which shows a housekeeping gene (HKG)'s properties of being constitutively expressed across a wide range of tissues.
The term “guide gene”, as used herein, is intended to refer to a gene, selected from among candidate reference genes, which shows as low an expression level and variation in expression level as most transcripts within cells, which is also expressed as “reference gene” or “endogenous reference gene”.
In accordance with an aspect thereof, the present invention provides a method for selecting candidate endogenous reference genes (ERG), comprising:
1) computing expression levels of genes from EST, SAGE and microarray datasets; and
2) identifying genes which are constitutively expressed across a wide range of tissues using the computed gene expression levels of step 1) and zero(0)'s proportions thereof.
Endogenous reference genes (ERG) are most widely used to normalize mRNA levels for an accurate comparison of gene expression between different samples. ERG is usually applied to gene expression analysis, such as RT-PCR (reverse transcriptase polymerase chain reaction), qRT-PCR (quantitative real time PCR), SAGE (serial analysis of gene expression) and microarray. Traditional reference genes, such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and β-actin (ACTB), have been used without proper validation, assuming that they are expressed at constant levels across different samples irrespectively the various origins thereof, and are not regulated according to experimental conditions. However, it is well known that the expression of traditional reference genes may differ from one tissue or cell type to another and can be regulated by experimental conditions, including sample treatment, developmental stage and pathological states.
In order to search for candidate housekeeping genes (HKG) whose expression is maintained on similar levels in most tissues, first, datasets were constructed using EST and SAGE human gene expression data collected from the publicly available CGAP site (The Cancer Genome Project, http://cgap.nci.nih.gov/) and microarray gene expression data obtained from the GeneExpress Oncology DatasuiteTM of Gene Logic Inc., based on the Affymetrix Human Genome U133 array set. Although the above-mentioned databases were combined to construct new datasets, it should be noted that availability is not limited to the databases. Using the expression data from the datasets, the expression level of a given gene is determined according to the following Mathematical Formulas 1 and 2. The EST (expressed sequence tag) expression levels and the SAGE expression levels of a gene in a given library can be calculated according to Mathematical Formulas 1 and 2, respectively



  
    
      
    
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In accordance with the present invention, data from the different databases were analyzed to determine their integrity and to identify commonality therebetween. In this regard, the concept of zero (0)'s proportion is introduced to determine the possibility that a given gene might be a housekeeping gene (HKG), which is ubiquitously expressed across most tissues.




  
    
      
        
      
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As expressed by Mathematical Formula 3, zero(0)'s proportion is defined as the ratio of the number of the tissues with no expression of a given gene to the total number of tissues. The lower the 0's proportion is, the higher is the possibility that the given gene might be an HKG. Utilizing the concept of 0's proportion, genes which have low 0's proportions in EST, ShortSAGE, LongSAGE datasets were sorted. 2,087 genes common to the 3 datasets were selected and categorized as “candidate reference genes” or “candidate ERGs”. The genes which have low 0's proportions refer to genes with 0's proportions less than 0.4 for EST, 0.1 for ShortSAGE, and 0.3 for LongSAGE. The mean gene expression values and CV (%) of the 2,087 candidate reference genes were calculated using another dataset, Affymetrix HG-U133, as well as in EST and SAGE datasets. The expression data of 1,990 UniGene clusters (gene expression data for 5,238 different probe sets, 5317 fragments) corresponding to 2,087 ERGs were obtained.
As a result, a significant correlation of the mean expression values is observed among all of the four datasets (EST (expressed sequence tag), ShortSAGE, LongSAGE and microarray dataset)) (see FIG. 3). Correlation analysis on CV showed lower agreement between datasets than on the mean gene expression levels, although a significant correlation was detected (see FIG. 4).
In addition, the candidate ERGs were compared with non-ERGs with regard to gene expression in each dataset. As we expected, the mean gene expression level of the candidate ERGs was significantly higher than that of non-ERGs in all of the four datasets (p<0.0001) (see FIG. 5).
In accordance with another aspect thereof, the present invention provides a composition for detecting at least one candidate endogenous reference gene selected according to the present invention, comprising a detection reagent applicable to amplification of the candidate endogenous reference gene.
The candidate endogenous reference gene useful in the present invention is one or more genes selected from a group consisting of Accession No. Hs 120(PRDX6), Accession No. Hs 142(SULT1A1), Accession No. Hs 202(BZRP), Accession No. Hs 429(ATP5G3), Accession No. Hs 695(CSTB), Accession No. Hs 808(HNRPF), Accession No. Hs 861(MAPK3), Accession No. Hs 1063(SNRPC), Accession No. Hs 1103(TGFB1), Accession No. Hs 2430(TCFL1), Accession No. Hs 2533(ALDH9A1), Accession No. Hs 2795(LDHA), Accession No. Hs 2853(PCBP1), Accession No. Hs 3100(KARS), Accession No. Hs 3254(MRPL23), Accession No. Hs 3353(G3BP), Accession No. Hs 3416(ADFP), Accession No. Hs 439(STOML2), Accession No. Hs 3530(FUSIP1), Accession No. Hs 3989(PLXNB2), Accession No. Hs 4055(KLF6), Accession No. Hs 4742(GPAA1), Accession No, Hs 4747(DKC1), Accession No. Hs 4766(FAM32A), Accession No. Hs 4859(CCNL1), Accession No. Hs 4997(RBM23), Accession No. Hs 4998(TMOD3), Accession No. Hs 5062(TM4SF8), Accession No. Hs 5086(MGC10433), Accession No. Hs 5120(DNCL1), Accession No. Hs 5158(ILK), Accession No. Hs 5245(FLJ20643), Accession No. Hs 5258(MAGED1), Accession No. Hs 5268(ZDHHC4), Accession No. Hs 5298(ADIPOR1), Accession No. Hs 5308(UBA52), Accession No. Hs 5324(C2orf25), Accession No. Hs 5345(RNPEPL1), Accession No. Hs 5662(GNB2L1), Accession No. Hs 5710(CREG1), Accession No. Hs 5719(CNAP1), Accession No. Hs 5912(FBXO7), Accession No. Hs 5947(RAB8A), Accession No. Hs 6396(JTB), Accession No. Hs 6454(RGS19IP1), Accession No. Hs 6459(GPR172A), Accession No. Hs 6551(ATP6AP1), Accession No. Hs 6891(SFRS6), Accession No. Hs 7101(ANAPC5), Accession No. Hs 7236(NOSIP), Accession No. Hs 7476(ATP6V0B), Accession No. Hs 7527(DKFZP566E144), Accession No. Hs 7744(NDUFV1), Accession No. Hs 7753(CALU), Accession No. Hs 7768 (FIBP), Accession No. Hs 7862(PNRC2), Accession No. Hs 7910(RYBP), Accession No. Hs 7917(HIG1), Accession No. Hs 8102(RPS20), Accession No. Hs 8372(UQCR), Accession No. Hs 8737(WDR6), Accession No. Hs 8752(TMEM4), Accession No. Hs 8765(DDX42), Accession No. Hs 8859(CANT1), Accession No. Hs 8867(CYR61), Accession No. Hs 9003(FLJ13868), Accession No. Hs 9015(MGC52000), Accession No. Hs 9043(C14orf120), Accession No. Hs 9234(NIFIE14), Accession No. Hs 9235(NME4), Accession No. Hs 9527(C2orf28), Accession No. Hs 9534(SEC11L1), Accession No. Hs 9573(ABCF1), Accession No. Hs 9589(UBQLN1), Accession No. Hs 9788(NDFIP1), Accession No. Hs 9825(CGI-128), Accession No. Hs 9857(DCXR), Accession No. Hs 10326(COPE), Accession No. Hs 10842(RAN), Accession No. Hs 10848(BMS1L), Accession No. Hs 11125(SPCS1), Accession No. Hs 11184(UBE2R2), Accession No. Hs 11223(IDH1), Accession No. Hs 11355(TMPO), Accession No. Hs 11463(UMP-CMPK), Accession No. Hs 12013(ABCE1), Accession No. Hs 12084(TUFM), Accession No. Hs 12102(SNX3), Accession No. Hs 12107(BC-2), Accession No. Hs 12109(WDR39), Accession No. Hs 12144(KIAA1033), Accession No. Hs 12152(SRPRB), Accession No. Hs 12272(BECN1), Accession No. Hs 12341(ADAR), Accession No. Hs 12457(NUP133), Accession No. Hs 12865(NSFLIC), Accession No. Hs 13662(MGC5508), Accession No. Hs 14317(NOLA3), Accession No. Hs 14333(FLJ10349), Accession No. Hs 14745(C10orf9), Accession No. Hs 14839(POLR2G), Accession No. Hs 14846(SLC7A1), Accession No. Hs 14894(TGOLN2), Accession No. Hs 15277(C16orf33), Accession No. Hs 15591(COPS6), Accession No. Hs 15738(RAB7), Accession No. Hs 16059(HSPC009), Accession No. Hs 16130(E2-230K), Accession No. Hs 16349(KIAA0431), Accession No. Hs 17118(FLJ11730), Accession No. Hs 17250(MGC4767), Accession No. Hs 17680(FUCA2), Accession No. Hs 17731(FLJ12892), Accession No. Hs 17883(PPM1G), Accession No. Hs 18069(LGMN), Accession No. Hs 18128(C20orf44), Accession No. Hs 18349(MRPL15), Accession No. Hs 19673(MAF1), Accession No. Hs 20013(P29), Accession No. Hs 20107(KNS2), Accession No. Hs 20157(CDK5RAP3), Accession No. Hs 20521(HRMT1L2), Accession No. Hs 20529(LOC127262), Accession No. Hs 20573(IGF1R), Accession No. Hs 20716(TIMM17A), Accession No. Hs 22393(DENR), Accession No. Hs 22543(UBE3A), Accession No. Hs 22546(CYBASC3), Accession No. Hs 22616(KIAA0664), Accession No. Hs 23033(LOC92912), Accession No. Hs 23111(FARSLA), Accession No. Hs 23978(SAFB), Accession No. Hs 24301(POLR2E), Accession No. Hs 24379(TRAPPC1), Accession No. Hs 24601(FBLN1), Accession No. Hs 24950(RGS5), Accession No. Hs 25155(NET1), Accession No. Hs 25450(SLC29A1), Accession No. Hs 25723(MTVR1), Accession No. Hs 26010(PFKP), Accession No. Hs 26023(FOXJ3), Accession No. Hs 26136(MGC14156), Accession No. Hs 26232(MAN2C1), Accession No. Hs 26403(GSTZ1), Accession No. Hs 26518(TM4SF7), Accession No. Hs 27222(NOLA2), Accession No. Hs 28491(SAT), Accession No. Hs 28914(APRT), Accession No. Hs 29203(GBL), Accession No. Hs 29665(CLSTN1), Accession No. Hs 30011(MGC2963), Accession No. Hs 30026(HSPC182), Accession No. Hs 30345(TRAP1), Accession No. Hs 30954(PMVK), Accession No. Hs 31053(CKAP1), Accession No. Hs 31334(C20orf14), Accession No. Hs 31387(DKFZP564J0123), Accession No. Hs 34045(CDCA4), Accession No. Hs 34576(TAX1BP1), Accession No. Hs 34906(BLOC1S2), Accession No. Hs 35052(TEGT), Accession No. Hs 35828(MARK3), Accession No. Hs 36587(PPP1R7), Accession No. Hs 36927(HSPH1), Accession No. Hs 37616(STRA13), Accession No. Hs 37916(DPP7), Accession No. Hs 42806(Cab45), Accession No. Hs 43297(MTPN), Accession No. Hs 47062(POLR2I), Accession No. Hs 50098(NDUFA4), Accession No. Hs 50308(HIP2), Accession No. Hs 50425(TEBP), Accession No. Hs 53066(HSPBP1), Accession No. Hs 54277(FAM50A), Accession No. Hs 54457(CD81), Accession No. Hs 54642(MAT2B), Accession No. Hs 54649(RY1), Accession No. Hs 55682(EIF3S7), Accession No. Hs 55847(MRPL51), Accession No. Hs 58488(CTNNAL1), Accession No. Hs 58992(SMC4L1), Accession No. Hs 59486(HSDL2), Accession No. Hs 61812(PTPN12), Accession No. Hs 65234(DDX27), Accession No. Hs 65238(RNF40), Accession No. Hs 66048(BPY2IP1), Accession No. Hs 66915(C22orf16), Accession No. Hs 68714(SFRS1), Accession No. Hs 9293(HEXB), Accession No. Hs 69554(RNF126), Accession No. Hs 69855(UNR), Accession No. Hs 71465(SQLE), Accession No. Hs 71787(MRPS7), Accession No. Hs 73527(CSNK2B), Accession No. Hs 73722(APEX1), Accession No. Hs 73799(GNAI3), Accession No. Hs 73965(SFRS2), Accession No. Hs 74047(ETFB), Accession No. Hs 74050(FVT1), Accession No. Hs 74137(TMP21), Accession No. Hs 74375(DVL1), Accession No. Hs 74405(YWHAQ), Accession No. Hs 74471(GJA1), Accession No. Hs 74563(OAZ2), Accession No. Hs 74564(SSR2), Accession No. Hs 74576(GDI1), Accession No. Hs 75056(TIMM13), Accession No. Hs 75061(MARCKSL1), Accession No. Hs 75066(TSN), Accession No. Hs 75087(FASTK), Accession No. Hs 75117(ILF2), Accession No. Hs 75133(TFAM), Accession No. Hs 75139(ARFIP2), Accession No. Hs 75189(DAP), Accession No. Hs 75227(NDUFA9), Accession No. Hs 75243(BRD2), Accession No. Hs 75249(ARL6IP), Accession No. Hs 75254(IRF3), Accession No. Hs 75318(TUBA1), Accession No. Hs 75348(PSME1), Accession No. Hs 75438(QDPR), Accession No. Hs 75527(ADSL), Accession No. Hs 75724(COPB2), Accession No. Hs 75798(C20orf111), Accession No. Hs 75841(C12orf8), Accession No. Hs 75890(MBTPS1), Accession No. Hs 75914(RNP24), Accession No. Hs 76111(DAG1), Accession No. Hs 76394(ECHS1), Accession No. Hs 76480(UBL4), Accession No. Hs 76662(ZDHHC16), Accession No. Hs 76686(GPX1), Accession No. Hs 76847(GANAB), Accession No. Hs 77060(PSMB6), Accession No. Hs 77269(GNAI2), Accession No. Hs 77313(CDK10), Accession No. Hs 77422(PLP2), Accession No. Hs 77558(HMGN3), Accession No. Hs 77578(USP9X), Accession No. Hs 77793(CSK), Accession No. Hs 77897(SF3A3), Accession No. Hs 77961(HLA-B), Accession No. Hs 77978(DKFZp761I2123), Accession No. Hs 78466(PSMD8), Accession No. Hs 78601(UROD), Accession No. Hs 78771(PGK1), Accession No. Hs 78880(ILVBL), Accession No. Hs 78888(DBI), Accession No. Hs 78989(ADH5), Accession No. Hs 79064(DHPS), Accession No. Hs 79081(PPP1CC), Accession No. Hs 79088(RCN2), Accession No. Hs 79101(CCNG1), Accession No. Hs 79110(NCL), Accession No. Hs 79322(QARS), Accession No. Hs 79335(SMARCD1), Accession No. Hs 79387(PSMC5), Accession No. Hs 79402(POLR2C), Accession No. Hs 79411(RPA2), Accession No. Hs 79625(C20orf149), Accession No. Hs 80545(RPL37), Accession No. Hs 80919(SYPL), Accession No. Hs 80986(ATP5G1), Accession No. Hs 81328(NFKBIA), Accession No. Hs 81424(SUMO1), Accession No. Hs 81848(RAD21), Accession No. Hs 81964(SEC24C), Accession No. Hs 82201(CSNK2A2), Accession No. Hs 82327(GSS), Accession No. Hs 82719(MGC21416), Accession No. Hs 82793(PSMB3), Accession No. Hs 82887(PPP1R1), Accession No. Hs 82890(DAD1), Accession No. Hs 82916(CCT6A), Accession No. Hs 82927(AMPD2), Accession No. Hs 83190(FASN), Accession No. Hs 83347(AAMP), Accession No. Hs 83383(PRDX4), Accession No. Hs 83734(STX4A), Accession No. Hs 83753(SNRPB), Accession No. Hs 83765(DHFR), Accession No. Hs 83916(NDUFA5), Accession No. Hs 84359(GABARAP), Accession No. Hs 84753(FLJ12442), Accession No. Hs 85155(ZFP36L1), Accession No. Hs 85769(ERBP), Accession No. Hs 85962(DERPC), Accession No. Hs 86131(FADD), Accession No. Hs 87752(MSN), Accession No. Hs 89545(PSMB4), Accession No. Hs 89643(TKT), Accession No. Hs 89649(EPHX1), Accession No. Hs 89781(UBTF), Accession No. Hs 89864(SKIV2L), Accession No. Hs 90061(PGRMC1), Accession No. Hs 90093(HSPA4), Accession No. Hs 90107(ADRM1), Accession No. Hs 90443(NDUFS8), Accession No. Hs 91142(KHSRP), Accession No. Hs 91531(MLLT6), Accession No. Hs 93659(ERP70), Accession No. Hs 93832(LOC54499), Accession No. Hs 95577(CDK4), Accession No. Hs 96530(COX11), Accession No. Hs 96852(FLJ21128), Accession No. Hs 96996(HNRPA0), Accession No. Hs 97616(SH3GL1), Accession No. Hs 97887(RCN1), Accession No. Hs 98751(FUBP3), Accession No. Hs 98791(ACTR1B), Accession No. Hs 102696(MCTS1), Accession No. Hs 102798(PSMA1), Accession No. Hs 103561(ARL6IP4), Accession No. Hs 103834(MGC5576), Accession No. Hs 104839(TIMP2), Accession No. Hs 105547(NPDC1), Accession No. Hs 106185(RALGDS), Accession No. Hs 106876(ATP6V0D1), Accession No. Hs 106909(ANAPC13), Accession No. Hs 107003(CCNB1IP1), Accession No. Hs 107101(FLJ31031), Accession No. Hs 107387(C7orf20), Accession No. Hs 107393(C3orf4), Accession No. Hs 108029(SH3BGRL), Accession No. Hs 108080(CSRP1), Accession No. Hs 108371(E2F4), Accession No. Hs 108408(APH-1A), Accession No. Hs 108957(RPS27L), Accession No. Hs 108969(PTD008), Accession No. Hs 109051(SH3BGRL3), Accession No. Hs 109052(C14orf2), Accession No. Hs 109672(SIAT7F), Accession No. Hs 109798(C6orf48), Accession No. Hs 110695(SF3B5), Accession No. Hs 110849(ESRRA), Accession No. Hs 111286(MRPS11), Accession No. Hs 111577(ITM2C), Accession No. Hs 11801(ARS2), Accession No. Hs 112058(SIVA), Accession No. Hs 112318(TOMM7), Accession No. Hs 112955(NUDT5), Accession No. Hs 114033(SSR1), Accession No. Hs 114286(CD9), Accession No. Hs 114412(TXNL1), Accession No. Hs 115474(RFC3), Accession No. Hs 115792(EXOSC7), Accession No. Hs 116448(GLS), Accession No. Hs 117176(PABPN1), Accession No. Hs 117715(ST5), Accession No. Hs 118110(BST2), Accession No. Hs 118400(FSCN1), Accession No. Hs 118463(PNPLA2), Accession No. Hs 118638(NME1), Accession No. Hs 118722(FUT8), Accession No. Hs 118964(p66alpha), Accession No. Hs S18983(GSDMDC1), Accession No. Hs 19177(ARF3), Accession No. Hs 119192(H2AFZ), Accession No. Hs 119251(UQCRC1), Accession No. Hs 119591(AP2S1), Accession No. Hs 119598(RPL3), Accession No. Hs 120323(DNAPTP6), Accession No. Hs 121088(NUP153), Accession No. Hs 121549(CDIPT), Accession No. Hs 122363(WIP1-2), Accession No. Hs 122523(SND1), Accession No. Hs 124126(ARPC1A), Accession No. Hs 124147(FBXL11), Accession No. Hs 124246(C10orf119), Accession No. Hs 124366(BBX), Accession No. Hs 125113(CCT8), Accession No. Hs 125867(EVL), Accession No. Hs 125898(GNAS), Accession No. Hs 126497(AEBP2), Accession No. Hs 126774(RAMP), Accession No. Hs 126938(NAPA), Accession No. Hs 127092(DHX38), Accession No. Hs 127249(EAP30), Accession No. Hs 127386(MAMDC2), Accession No. Hs 127764(RAB5C), Accession No. Hs 128065(CTSC), Accession No. Hs 128199(SEPT11), Accession No. Hs 128548(WDR1), Accession No. Hs 129634(CINP), Accession No. Hs 129673(EIF4A1), Accession No. Hs 130031(TRIO), Accession No. Hs 130098(DDX23), Accession No. Hs 130293(CROP), Accession No. Hs 130413(TM9SF2), Accession No. Hs 131226(BNIP3L), Accession No. Hs 132497(PRNPIP), Accession No. Hs 132513 HSD17B12), Accession No. Hs 133892(TPM1), Accession No. Hs 134074(SLC35E1), Accession No. Hs 134688(PSMD13), Accession No. Hs 135406(CEBPZ), Accession No. Hs 136905(UREB1), Accession No. Hs 136947(RALY), Accession No. Hs 137510(NCOR2), Accession No. Hs 138860(ARHGAP1), Accession No. Hs 139896(MAEA), Accession No. Hs 140452(M6PRBP1), Accession No. Hs 142442(HP1-BP74), Accession No. Hs 143187(DDX49), Accession No. Hs 143766(DRPLA), Accession No. Hs 143873(S100A10), Accession No. Hs 144058(EBSP), Accession No. Hs 144468(MGC3234), Accession No. Hs 144835(EEF1G), Accession No. Hs 144868(VTI1B), Accession No. Hs 144941(MUF1), Accession No. Hs 144949(ZNF313), Accession No. Hs 144980(SCAMP4), Accession No. Hs 145049(PLEKHM2), Accession No. Hs 145442(MAP2K1), Accession No. Hs 145575(UBL3), Accession No. Hs 146070(TPM3), Accession No. Hs 146393(HERPUD1), Accession No. Hs 146602(QP-C), Accession No. Hs 146804(SPIN), Accession No. Hs 146806(CUL1), Accession No. Hs 147433(PCNA), Accession No. Hs 148078(RBAF600), Accession No. Hs 148272(CCM2), Accession No. Hs 148330(ARF4), Accession No. Hs 148340(PTPRG), Accession No. Hs 148670(RHOBTB1), Accession No. Hs 149004(FBXO31), Accession No. Hs 149957(RPS6KA1), Accession No. Hs 149983(PEX14), Accession No. Hs 150107(BIRC6), Accession No. Hs 150540(BC002942), Accession No. Hs 150580(SUI1), Accession No. Hs 150837(TXNDC5), Accession No. Hs 151134(OXA1L), Accession No. Hs 151220(KIAA0992), Accession No. Hs 151413(GMFB), Accession No. Hs 151787(U5-116KD), Accession No. Hs 152536(p44S10), Accession No. Hs 153177(RPS28), Accession No. Hs 154023(TXNDC4), Accession No. Hs 154073(SLC35B1), Accession No. Hs 155165(ZFPL1), Accession No. Hs 155218(HNRPUL1), Accession No. Hs 155396(NFE2L2), Accession No. Hs 155829(KIAA0676), Accession No. Hs 156171(PSMC6), Accession No. Hs 156367(RPS29), Accession No. Hs 156667(KIAA1536), Accession No. Hs 157160(MRPS34), Accession No. Hs 157351(PTD004), Accession No. Hs 157379(H2AFV), Accession No. Hs 157394(HAGH), Accession No. Hs 159014(PRPF4B), Accession No. Hs 159118(AMD1), Accession No. Hs 159130(RAF1), Accession No. Hs 159161(ARHGDIA), Accession No. Hs 159699(FBXO21), Accession No. Hs 159799(THRAP2), Accession No. Hs 160958(CDC37), Accession No. Hs 161357(PDHB), Accession No. Hs 162032(HBP1), Accession No. Hs 162233(CHD4), Accession No. Hs 162877(PACSIN2), Accession No. Hs 163645(MOCS2), Accession No. Hs 163776(UBE2J1), Accession No. Hs 163893(PICALM), Accession No. Hs 165195(VAPA), Accession No. Hs 166011(CTNND1), Accession No. Hs 166204(PHF1), Accession No. Hs 166463(HNRPU), Accession No. Hs 166924(SEC13L1), Accession No. Hs 166975(SFRS5), Accession No. Hs 167535(SRP54), Accession No. Hs 168073(TRPC4AP), Accession No. Hs 168799(METTL3), Accession No. Hs 169611(DIABLO), Accession No. Hs 169718(CNN2), Accession No. Hs 170107(UQCRFS1), Accession No. Hs 170131(NFIC), Accession No. Hs 170553(CNOT7), Accession No. Hs 170622(CFL1), Accession No. Hs 171626(SKP1A), Accession No. Hs 172550(PTBP1), Accession No. Hs 172755(BRP44L), Accession No. Hs 172928(COL1A1), Accession No. Hs 173024(NYREN18), Accession No. Hs 173162(NOC4), Accession No. Hs 173381(DPYSL2), Accession No. Hs 173464(FKBP8), Accession No. Hs 173611(NDUFS2), Accession No. Hs 173705(LOC401152), Accession No. Hs 173724(CKB), Accession No. Hs 174050(EDF1), Accession No. Hs 174195(IFITM2), Accession No. Hs 175473(AK1), Accession No. Hs 175955(YT521), Accession No. Hs 177530(ATP5E), Accession No. Hs 177766(PARP1), Accession No. Hs 178551(RPL8), Accession No. Hs 178728(MBD3), Accession No. Hs 179986(FLOT1), Accession No. Hs 180141(CFL2), Accession No. Hs 180312(MRPS16), Accession No. Hs 180414(HSPA8), Accession No. Hs 180877(H3F3B), Accession No. Hs 180903(384D8-2), Accession No. Hs 180909(PRDX1), Accession No. Hs 180933(CXXC1), Accession No. Hs 181046(DUSP3), Accession No. Hs 181112(MED4), Accession No. Hs 181163(HMGN2), Accession No. Hs 181244(HLA-A), Accession No. Hs 181368(PRPF8), Accession No. Hs 181444(TMEM9), Accession No. Hs 182255(NHP2L1), Accession No. Hs 182626(C22orf5), Accession No. Hs 182885(SLC35B2), Accession No. Hs 183684(EIF4G2), Accession No. Hs 183706(ADD1), Accession No. Hs 183800(RANGAP1), Accession No. Hs 183850(DCTD), Accession No. Hs 183994(PPP1CA), Accession No. Hs 184062(C20orf24), Accession No. Hs 184211(PMPCB), Accession No. Hs 184233(HSPA9B), Accession No. Hs 184492(ELAVL1), Accession No. Hs 185172(GNB2), Accession No. Hs 185597(SPG7), Accession No. Hs 187199(MALAT1), Accession No. Hs 187635(RPS15A), Accession No. Hs 187763(BRD4), Accession No. Hs 187866(SDFR1), Accession No. Hs 187946(SLC20A 1), Accession No. Hs 188501 (PAFAH1B2), Accession No. Hs 188614(PLEKHA5), Accession No. Hs 188879(RBM6), Accession No. Hs 188882(NUDT3), Accession No. Hs 189075(PTK9), Accession No. Hs 189119(CXXC5), Accession No. Hs 189329(SMURF1), Accession No. Hs 189716(NDUFAB1), Accession No. Hs 189772(CCT2), Accession No. Hs 190028(GSTO1), Accession No. Hs 190086(MRCL3), Accession No. Hs 190334(RAP1A), Accession No. Hs 190384(COPS4), Accession No. Hs 190722(HSPC142), Accession No. Hs 190904(STRN4), Accession No. Hs 191186(TTC17), Accession No. Hs 191346(SEPT7), Accession No. Hs 191518(DHX9), Accession No. Hs 191987(UBE2J2), Accession No. Hs 192316(CDC2L1), Accession No. Hs 192374(TRA1), Accession No. Hs 192425(EIF3S8), Accession No. Hs 193118(RAI17), Accession No. Hs 193163(BIN1), Accession No. Hs 193491(TUBB6), Accession No. Hs 194329(TCEAL4), Accession No. Hs 194718(ZNF265), Accession No. Hs 195464(FLNA), Accession No. Hs 195642(C17orf27), Accession No. Hs 196983(SSFA2), Accession No. Hs 198281(PKM2), Accession No. Hs 199561(RANBP2), Accession No. Hs 199625(HAX1), Accession No. Hs 200063(HDAC7A), Accession No. Hs 200600(SCAMP3), Accession No. Hs 200804(SDCBP), Accession No. Hs 201253(ch-TOG), Accession No. Hs 201390(WDR45L), Accession No. Hs 201712(GLG1), Accession No. Hs 202011(GK001), Accession No. Hs 202085(VDAC1), Accession No. Hs 202166(HNRPH1), Accession No. Hs 202179(SMN2), Accession No. Hs 203099(KIAA0261), Accession No. Hs 203910(SGTA), Accession No. Hs 204041(AHSA1), Accession No. Hs 204773(MEP50), Accession No. Hs 205163(MRPL3), Accession No. Hs 206500(CTTN), Accession No. Hs 206824(MGC71993), Accession No. Hs 208597(CTBP1), Accession No. Hs 209983(STMN1), Accession No. Hs 210469(ELMO2), Accession No. Hs 210532(KIAA0141), Accession No. Hs 211463(DNM2), Accession No. Hs 211594(PSMC4), Accession No. Hs 211914(NDUFS7), Accession No. Hs 212102(TXNDC7), Accession No. Hs 212395(CIZ1), Accession No. Hs 213061(NUCKS), Accession No. Hs 213470(PSMB7), Accession No. Hs 213541, Accession No. Hs 213666(KIAA0460), Accession No. Hs 213724(SUPT16H), Accession No. Hs 216653(FBXO9), Accession No. Hs 220950(FOXO3A), Accession No. Hs 221847(SLC38A2), Accession No. Hs 222510(DAZAP1), Accession No. Hs 223141(DDX21), Accession No. Hs 224607(SDC1), Accession No. Hs 226007(RDH11), Accession No. Hs 226117(H1F0), Accession No. Hs 226755(YWHAH), Accession No. Hs 227067(ATAD3A), Accession No. Hs 227253(TOMM70A), Accession No. Hs 227777(PTP4A1), Accession No. Hs 229641(PC4), Accession No. Hs 231295(PITPNC1), Accession No. Hs 231616(HSPC023), Accession No. Hs 232194(KIAA0174), Accession No. Hs 232543(PDCD4), Accession No. Hs 233458(NFYC), Accession No. Hs 233552(CDC2L5), Accession No. Hs 233952(PSMA7), Accession No. Hs 2345211(MAPKAPK3), Accession No. Hs 236030(SMARCC2), Accession No. Hs 237536(MGC20781), Accession No. Hs 237971(XTP3TPA), Accession No. Hs 238839(SCYL1), Accession No. Hs 240170(MGC2731), Accession No. Hs 241336(ATPIF1), Accession No. Hs 241543(POLDIP2), Accession No. Hs 241558(ARIH2), Accession No. Hs 241575(GNPTG), Accession No. Hs 241576(DERL1), Accession No. Hs 241579(SERPINH1), Accession No. Hs 242458(SPG21), Accession No. Hs 242947(DGKI), Accession No. Hs 246112(ASCC3L1), Accession No. Hs 246310(ATP5J), Accession No. Hs 246413(CPNE1), Accession No. Hs 246781(FBXO1), Accession No. Hs 247077(RHOA), Accession No. Hs 247186(FBS1), Accession No. Hs 247975(HSPD1), Accession No. Hs 248267(MPST), Accession No. Hs 248941(TAF9), Accession No. Hs 49600(DLGAP4), Accession No. Hs 250009(ARL10C), Accession No. Hs 250429(SUPT6H), Accession No. Hs 250758(PSMC3), Accession No. Hs 250899(HSBP1), Accession No. Hs 250905(LOC51234), Accession No. Hs 251531(PSMA4), Accession No. Hs 252457(MVD), Accession No. Hs 252713(TTC15), Accession No. Hs 252967 DKFZp566C0424), Accession No. Hs 253726(PAPOLA), Accession No. Hs 253903(STOM), Accession No. Hs 254042(BAT1), Accession No. Hs 255015(VPS24), Accession No. Hs 255093(PFKL), Accession No. Hs 255932(XRN2), Accession No. Hs 255935(BTG1), Accession No. Hs 255973(CRI1), Accession No. Hs 256301(MGC13170), Accession No. Hs 256549(NUBP2), Accession No. Hs 257008(PLD3), Accession No. Hs 257341(SAV1), Accession No. Hs 57761(SH3BP5), Accession No. Hs 258551(DNPEP), Accession No. Hs 258563(FEZ2), Accession No. Hs 258798 C10orf86), Accession No. Hs 259461(PALM2-AKAP2), Accession No. Hs 260603(PIP5K2B), Accession No. Hs 262823(FLJ10326), Accession No. Hs 265829(ITGA3), Accession No. Hs 268488(KIAA1185), Accession No. Hs 268530(GPS1), Accession No. Hs 268742(C13orf12), Accession No. Hs 268849(GLO1), Accession No. Hs 268939(MATR3), Accession No. Hs 269528(MAK3), Accession No. Hs 269577(PTPRA), Accession No. Hs 269782(GNAQ), Accession No. Hs 269944(MTCH2), Accession No. Hs 270291(ACTN4), Accession No. Hs 270428(SUCLG1), Accession No. Hs 270525(LASS5), Accession No. Hs 270869(ZNF410), Accession No. Hs 271135(ATP5C1), Accession No. Hs 271695(NOB1P), Accession No. Hs 272062(PTPRF), Accession No. Hs 272168(TDE1), Accession No. Hs 272630(ATP6V1D), Accession No. Hs 272927(SEC23A), Accession No. Hs 273077(TMEM14B), Accession No. Hs 274184(TFE3), Accession No. Hs 274772(C15orf15), Accession No. Hs 274873(CARS), Accession No. Hs 275243(S100A6), Accession No. Hs 275775(SEPP1), Accession No. Hs 275865(PCNP), Accession No. Hs 276878(NUP93), Accession No. Hs 277035(MGLL), Accession No. Hs 277517(C11 orf2), Accession No. Hs 278186(ARHGEF1), Accession No. Hs 278362(MEA), Accession No. Hs 278426(PDAP1), Accession No. Hs 278429(C9orf78), Accession No. Hs 278500(GNPDA1), Accession No. Hs 278569(SNX17), Accession No. Hs 278573(CD59), Accession No. Hs 278721(SLC39A7), Accession No. Hs 279061(C17orf25), Accession No. Hs 279245(TACC1), Accession No. Hs 279257(PCMT1), Accession No. Hs 279413(POLD1), Accession No. Hs 279529(PX19), Accession No. Hs 279583(DREV1), Accession No. Hs 279623(SEPX1), Accession No. Hs 279640(TPR), Accession No. Hs 279652(MRPL4), Accession No. Hs 279669(TUBG1), Accession No. Hs 279696(SUMF2), Accession No. Hs 279806(DDX5), Accession No. Hs 79836(COMMD9), Accession No. Hs 279920(YWHAB), Accession No. Hs 279929(TMED9), Accession No. Hs 80202(SBF1), Accession No. Hs 280342(PRKAR1A), Accession No. Hs 280378(SNRPB2), Accession No. Hs 282410(CALM1), Accession No. Hs 282700(SPCS2), Accession No. Hs 282901(RNPC2), Accession No. Hs 282998(RBM9), Accession No. Hs 283111(C14orf124), Accession No. Hs 283454(BNIP2), Accession No. Hs 283521(RHEB), Accession No. Hs 283610(APG4B), Accession No. Hs 283652(IDI1), Accession No. Hs 283739(UBQLN4), Accession No. Hs 284208(ANKRD25), Accession No. Hs 284279(HMOX2), Accession No. Hs 284286(MRPS24), Accession No. Hs 284491(PDXK), Accession No. Hs 285354(MAX), Accession No. Hs 285976(LASS2), Accession No. Hs 286221(ARF1), Accession No. Hs 286226(MYO1C), Accession No. Hs 288193(KPNA4), Accession No. Hs 288856(PFDN5), Accession No. Hs 288969(HSCARG), Accession No. Hs 289008(C6orf68), Accession No. Hs 289092(COTL1), Accession No. Hs 289123(DCTN2), Accession No. Hs 289271(CYC1), Accession No. Hs 290243(GBF1), Accession No. Hs 290404(SLC25A3), Accession No. Hs 290758(DDB1), Accession No. Hs 291587(ARID1B), Accession No. Hs 292026(EIF4E2), Accession No. Hs 292063(EIF4B), Accession No. Hs 292078(LARP), Accession No. Hs 292265(ZMYND11), Accession No. Hs 292457, Accession No. Hs 292493(G22P1), Accession No. Hs 292524(CCNH), Accession No. Hs 292579(PTDSS1), Accession No. Hs 293563(FLJ12666), Accession No. Hs 295917(ATP6V1B2), Accession No. Hs 297324(TIMP3), Accession No. Hs 298198(CKLFSF3), Accession No. Hs 298280(ATP5A1), Accession No. Hs 298654(DUSP6), Accession No. Hs 299002(FBL), Accession No. Hs 299055(GD12), Accession No. Hs 300141(RPL39), Accession No. Hs 300684(RCP9), Accession No. Hs 300772(TPM2), Accession No. Hs 300816 RAB1B), Accession No. Hs 300834(GALNT2), Accession No. Hs 301404(RBM3), Accession No. Hs 301412(Ufc1), Accession No. Hs 302742(MRPS6), Accession No. Hs 302903(UBE21), Accession No. Hs 303676(G3BP2), Accession No. Hs 304192(DSTN), Accession No. Hs 304682(CST3), Accession No. Hs 306123(MAGEF1), Accession No. Hs 306242(RANBP9), Accession No. Hs 306329(ZA20D3), Accession No. Hs 306425(IBTK), Accession No. Hs 308122(ITPK1), Accession No. Hs 308340(NUP188), Accession No. Hs 308709(GRP58), Accession No. Hs 309090(SFRS7), Accession No. Hs 309231(C6orf153), Accession No. Hs 309641(RNF11), Accession No. Hs 309753(STARD3NL), Accession No. Hs 309849(C14orf159), Accession No. Hs 310542(TOMM40), Accession No. Hs 310645(RAB1A), Accession No. Hs 311072(MRPS35), Accession No. Hs 311346(CMAS), Accession No. Hs 311609(DDX39), Accession No. Hs 311640(RPS27A), Accession No. Hs 312098(ADAM15), Accession No. Hs 313847(TXNDC11), Accession No. Hs 314263(BAZ2A), Accession No. Hs 314359(EIF3S12), Accession No. Hs 315177(IFRD2), Accession No. Hs 315230(GC20), Accession No. Hs 319334(NASP), Accession No. Hs 321391(MGC4549), Accession No. Hs 321541(RAB11A), Accession No. Hs 323363(APG9L1), Accession No. Hs 323489(FLJ20758), Accession No. Hs 324250(NDUFB2), Accession No. Hs 324844(VKORC1), Accession No. Hs 325650(EHD2), Accession No. Hs 326387(MORF4L2), Accession No. Hs 330384(CORO1C), Accession No. Hs 331431(SCC-112), Accession No. Hs 333388(EEF1D), Accession No. Hs 333579(HSPC152), Accession No. Hs 333786(PSMA2), Accession No. Hs 333823(MRPL13), Accession No. Hs 334017(K-ALPHA-1), Accession No. Hs 334479(TRAF7), Accession No. Hs 334534(GNS), Accession No. Hs 334587(RBPMS), Accession No. Hs 334713(BMSC-UbP), Accession No. Hs 334851(LASP1), Accession No. Hs 334868(PPP2R5E), Accession No. Hs 335003(ANKRD11), Accession No. Hs 335057(SEPT2), Accession No. Hs 335163(KIAA1102), Accession No. Hs 335918(FDPS), Accession No. Hs 337295(STIP1), Accession No. Hs 337766(TXNRD1), Accession No. Hs 339278(COPB), Accession No. Hs 339639(COX7A2L), Accession No. Hs 339697(GRINA), Accession No. Hs 343911(EI24), Accession No. Hs 345694(KCMF1), Accession No. Hs 346868(EBNA1BP2), Accession No. Hs 348418(DR1), Accession No. Hs 349656(SCARB2), Accession No. Hs 350194(ZMAT2), Accession No. Hs 350229(CASC3), Accession No. Hs 350268(IRF2BP2), Accession No. Hs 350364(C9orf10OS), Accession No. Hs 350927(SLC25A6), Accession No. Hs 351099(FLJ10241), Accession No. Hs 351296(LOC51035), Accession No. Hs 351316(TM4SF1), Accession No. Hs 351474(PAQR4), Accession No. Hs 351680, Accession No. Hs 351875(COX6C), Accession No. Hs 352341(STCH), Accession No. Hs 352656(GHITM), Accession No. Hs 352768(PSMB1), Accession No. Hs 354056(POR), Accession No. Hs 355141(TNIP1), Accession No. Hs 355606(MGC23909), Accession No. Hs 355643(RNPS1), Accession No. Hs 355708(FLJ20507), Accession No. Hs 355750(MGC5306), Accession No. Hs 355753(DKFZp586M1819), Accession No. Hs 355867(MARS), Accession No. Hs 355927(VDAC2), Accession No. Hs 355934(SFPQ), Accession No. Hs 355983(BZW1), Accession No. Hs 356061(MAP1LC3B), Accession No. Hs 356096(FLJ10350), Accession No. Hs 356190(UBB), Accession No. Hs 356270(SDHD), Accession No. Hs 356285(HMGN1), Accession No. Hs 356331(PPIA), Accession No. Hs 356366(RPS2), Accession No. Hs 356371(RPL28), Accession No. Hs 356377(LOC149603), Accession No. Hs 356467(MGC2747), Accession No. Hs 356501(PHF6), Accession No. Hs 356502(RPLP1), Accession No. Hs 356549(SNRPD3), Accession No. Hs 356630(NUTF2), Accession No. Hs 356647(SNX6), Accession No. Hs 356654(PSMC1), Accession No. Hs 56766( ), Accession No. Hs 356769(MAN2B1), Accession No. Hs 356799, Accession No. Hs 357901(SOX4), Accession No. Hs 362728(SEP15), Accession No. Hs 365116(U2AF1), Accession No. Hs 368084(LRPPRC), Accession No. Hs 368149(CCT7), Accession No. Hs 368157(PYGB), Accession No. Hs 368240(DYRK1A), Accession No. Hs 68264(PPP2R5C), Accession No. Hs 368376(SRPR), Accession No. Hs 368402(LOC51337), Accession No. Hs 368404(EXT2), Accession No. Hs 368525(PDLIM1), Accession No. Hs 368598(LEREPO4), Accession No. Hs 368934(MGC40157), Accession No. Hs 368985(TRIP12), Accession No. Hs 369017(RAB2), Accession No. Hs 369052(SELT), Accession No. Hs 369068(DNCLI2), Accession No. Hs 369125(PSMD14), Accession No. Hs 369285(DKFZP434B168), Accession No. Hs 369356(MLL5), Accession No. Hs 369606(CPSF6), Accession No. Hs 369607(GAK), Accession No. Hs 369614(COPS2), Accession No. Hs 369615(FLJ20551), Accession No. Hs 369761(DAZAP2), Accession No. Hs 369785(MGC2749), Accession No. Hs 369920(RAP1B), Accession No. Hs 370024(SEC31L1), Accession No. Hs 370247(APLP2), Accession No. Hs 370292(BCCIP), Accession No. Hs 370312(FNTA), Accession No. Hs 370408(COMT), Accession No. Hs 370581(CAP1), Accession No. Hs 370770(XPO1), Accession No. Hs 370771(CDKN1A), Accession No. Hs 370895(RPN2), Accession No. Hs 370927(PRO1855), Accession No. Hs 370937(TAPBP), Accession No. Hs 371001(EIF3S9), Accession No. Hs 371416(CARM1), Accession No. Hs 371563(RAB14), Accession No. Hs 371788(DKFZP547E1010), Accession No. Hs 371889(ATP1A1), Accession No. Hs 372003(C9orf10), Accession No. Hs 372050(SMAP-5), Accession No. Hs 372286(CUL3), Accession No. Hs 372331(SPTAN1), Accession No. Hs 372541(KBTBD2), Accession No. Hs 372616(ARL1), Accession No. Hs 372914(NDRG1), Accession No. Hs 373550(TGIF), Accession No. Hs 373741(HM13), Accession No. Hs 373763(HNRPR), Accession No. Hs 373952(CAMTA2), Accession No. Hs 373959(VGLL4), Accession No. Hs 374043(ASXL1), Accession No. Hs 374257(SIAT4A), Accession No. Hs 374378(CKS1B), Accession No. Hs 374477(EWSR1), Accession No. Hs 374503(MORF4L1), Accession No. Hs 374588(RPL17), Accession No. Hs 374596(TPT1), Accession No. Hs 374650(IFITM3), Accession No. Hs 374973(PRPF4), Accession No. Hs 375001(TLN1), Accession No. Hs 375108(CD24), Accession No. Hs 375217(RNF31), Accession No. Hs 376046(BTN3A2), Accession No. Hs 376933(GUK1), Accession No. Hs 377155(LYRIC), Accession No. Hs 378103(RPS5), Accession No. Hs 378532(HBS1L), Accession No. Hs 378808(eIF2A), Accession No. Hs 380403(PCGF4), Accession No. Hs 380774(DDX3X), Accession No. Hs 380953(RPL38), Accession No. Hs 380973(SUMO2), Accession No. Hs 381008(HLA-E), Accession No. Hs 381058(KIAA0146), Accession No. Hs 381072(PPIF), Accession No. Hs 381123(RPL21), Accession No. Hs 381126(RPS14), Accession No. Hs 381189(CBX3), Accession No. Hs 381219, Accession No. Hs 381256(GLTP), Accession No. Hs 382044(MRPS2), Accession No. Hs 382168(NCOA3), Accession No. Hs 385913(ANP32E), Accession No. Hs 385986(UBE2B), Accession No. Hs 386434(ANXA7), Accession No. Hs 386465(CHERP), Accession No. Hs 386939(USP7), Accession No. Hs 387208(FAU), Accession No. Hs 387804(PABPC1), Accession No. Hs 388034(RXRB), Accession No. Hs 388654(ATP6V1G1), Accession No. Hs 388664(RPL11), Accession No. Hs 388739(XRCC5), Accession No. Hs 388927(YY1), Accession No. Hs 388956(C19orf22), Accession No. Hs 389037(MCM3APAS), Accession No. Hs 389107(ATP6V0C), Accession No. Hs 389171(PINK1), Accession No. Hs 389649(DDX48), Accession No. Hs 389734(TCEAL8), Accession No. Hs 389996(CHCHD2), Accession No. Hs 390667(GSTK1), Accession No. Hs 393201(ACTR2), Accession No. Hs 395482(PTK2), Accession No. Hs 396644(PAIP2), Accession No. Hs 396740(NIP30), Accession No. Hs 396783(SLC9A3R1), Accession No. Hs 397609(RPS16), Accession No. Hs 399800(AKAP8L), Accession No. Hs 400295(RPL30), Accession No. Hs 401509(RBM10), Accession No. Hs 401903(COX5A), Accession No. Hs 401929(RPL10), Accession No. Hs 403917(STK24), Accession No. Hs 404056(EIF3S1), Accession No. Hs 404321(GARS), Accession No. Hs 405144(SFRS3), Accession No. Hs 405410(OGT), Accession No. Hs 405514(LOC284058), Accession No. Hs 405590(EIF3S6), Accession No. Hs 405880(MRPS21), Accession No. Hs 405942(LOC339229), Accession No. Hs 406062(NDUFA11), Accession No. Hs 406068(UBE2M), Accession No. Hs 406096(ZA20D2), Accession No. Hs 406277(SF3A1), Accession No. Hs 406300(RPL23), Accession No. Hs 406423(SF3B2), Accession No. Hs 406510(ATP5B), Accession No. Hs 406520(LOC389541), Accession No. Hs 406534(HMG20B), Accession No. Hs 406590(PGR1), Accession No. Hs 406620(RPS10), Accession No. Hs 406683(RPS15), Accession No. Hs 406799(RAB18), Accession No. Hs 406840(SLC35A4), Accession No. Hs 407368(C19orf13), Accession No. Hs 407580(PKP4), Accession No. Hs 407995(MIF), Accession No. Hs 408018(RPL36), Accession No. Hs 408073(RPS6), Accession No. Hs 408236(TXNL5), Accession No. Hs 408257(NDUFS6), Accession No. Hs 408293(KAB), Accession No. Hs 408324(FLJ10769), Accession No. Hs 408428(CHES1), Accession No. Hs 408581(SVIL), Accession No. Hs 408909(GOLPH3), Accession No. Hs 409140(ATP5O), Accession No. Hs 409223(SSR4), Accession No. Hs 409230(AGPAT1), Accession No. Hs 409834(PHPT1), Accession No. Hs 410197(IDH3G), Accession No. Hs 410596(HAN11), Accession No. Hs 410817(RPL13), Accession No. Hs 411480(AUP1), Accession No. Hs 411641(EIF4EBP1), Accession No. Hs 411847(MAPK6), Accession No. Hs 412103(EFHA1), Accession No. Hs 412117(ANXA6), Accession No. Hs 412196(ESRRBL1), Accession No. Hs 412433(AIP), Accession No. Hs 412468(KLHDC3), Accession No. Hs 412842(C10orf7), Accession No. Hs 413036(WBSCR22), Accession No. Hs 413482(C21orf33), Accession No. Hs 414579(SCOTIN), Accession No. Hs 415342(KIAA1049), Accession No. Hs 416049(TNPO2), Accession No. Hs 416436(TRIM50A), Accession No. Hs 417004(S100A11), Accession No. Hs 417029(DERP6), Accession No. Hs 418123(CTSL), Accession No. Hs 418175(VPS28), Accession No. Hs 418233(MRPL24), Accession No. Hs 418450(MRPL11), Accession No. Hs 418533(BUB3), Accession No. Hs 418668(ATP5D), Accession No. Hs 419640(PARK7), Accession No, Hs 420269(COL6A2), Accession No. Hs 420272(H2AFY), Accession No. Hs 421257(RPL7), Accession No. Hs 421509(CCT4), Accession No. Hs 422113(ZNF511), Accession No. Hs 423935(RDBP), Accession No. Hs 423968(TTC11), Accession No. Hs 424126(SERF2), Accession No. Hs 424908(LSM5), Accession No. Hs 425777(UBE2L6), Accession No. Hs 426296(C10orf104), Accession No. Hs 426359(DKFZp564J157), Accession No. Hs 429052(ITGB1), Accession No. Hs 429353(SEPN1), Accession No. Hs 429581(RTN4), Accession No. Hs 429819(PITPNA), Accession No. Hs 429839(MGC23908), Accession No. Hs 430425(GNB1), Accession No. Hs 430551(IQGAP1), Accession No. Hs 430606(CS), Accession No. Hs 430657(ARF5), Accession No. Hs 430733(CLNS1A), Accession No. Hs 431101(GNG12), Accession No. Hs 431367(C6orf55), Accession No. Hs 431498(FOXP1), Accession No. Hs 431550(MAP4K4), Accession No. Hs 431668(COX6B1), Accession No. Hs 431850(MAPK1), Accession No. Hs 431861(PPP5C), Accession No. Hs 431926 NFKB1), Accession No. Hs 432121(PRDX2), Accession No. Hs 432438(EML4), Accession No. Hs 432491(ESD), Accession No. Hs 432690(SLC39A9), Accession No. Hs 432760(CAPZB), Accession No. Hs 432898(RPL4), Accession No. Hs 432976(NR1H2), Accession No. Hs 433154(PLSCR3), Accession No. Hs 433201(CDK2AP1), Accession No. Hs 433222(NPC2), Accession No. Hs 433291(ARD1), Accession No. Hs 433307(BCKDHA), Accession No. Hs 433343(SRRM2), Accession No. Hs 433345, Accession No. Hs 433419(COX41), Accession No. Hs 433512(ACTR3), Accession No. Hs 433529(RPS11), Accession No. Hs 433540(DNAJC8), Accession No. Hs 433573(Bles03), Accession No. Hs 433615(TUBB2), Accession No. Hs 433701(RPL37A), Accession No. Hs 433722(K1AA1967), Accession No. Hs 33732(CLK1), Accession No. Hs 433750(EIF4G1), Accession No. Hs 433759(BANF1), Accession No. Hs 433795(SHC1), Accession No. Hs 433863(PBP), Accession No. Hs 433901(COX8A), Accession No. Hs 433951(GPX4), Accession No. Hs 434102(HMGB1), Accession No. Hs 434207(HARS2), Accession No. Hs 434219(ANKHD1), Accession No. Hs 434401(ZNF638), Accession No. Hs 434937(PPIB), Accession No. Hs 434953(HMGB2), Accession No. Hs 434980(APP), Accession No. Hs 435044(TBC1D22A), Accession No. Hs 435064(KIAA1608), Accession No. Hs 435120(KIF1C), Accession No. Hs 435136(TXN), Accession No. Hs 435166(LBR), Accession No. Hs 435231(ZFR), Accession No. Hs 435255(UBXD1), Accession No. Hs 435326(ACTL6A), Accession No. Hs 435512(PPP3CA), Accession No. Hs 435535(ZNF395), Accession No. Hs 435610(WAC), Accession No. Hs 435741(GCSH), Accession No. Hs 435759(THAP4), Accession No. Hs 435771(API5), Accession No. Hs 435841(TNRC15), Accession No. Hs 435850(LYPLA1), Accession No. Hs 435933(PHF10), Accession No. Hs 435948(ATAD1), Accession No. Hs 435952(CDK5RAP1), Accession No. Hs 435974(MTHFD1), Accession No. Hs 436035(TUBA6), Accession No. Hs 436093(BAT2), Accession No. Hs 436204(ZNF289), Accession No. Hs 436298(EMP1), Accession No. Hs 436405(IDH3B), Accession No. Hs 436437(ALDH2), Accession No. Hs 436446(ARMET), Accession No. Hs 436500(DBNL), Accession No. Hs 436568(CD74), Accession No. Hs 436578(POLR2F), Accession No. Hs 436657(CLU), Accession No. Hs 436687(SET), Accession No. Hs 436803(VBP1), Accession No. Hs 437056(SUPT5H), Accession No. Hs 437060(CYCS), Accession No. Hs 437110(ANXA2), Accession No. Hs 437178(ACADVL), Accession No. Hs 437256(GRINL1A), Accession No. Hs 437277(MGAT4B), Accession No. Hs 437367(GBAS), Accession No. Hs 437388(PIGT), Accession No. Hs 437403(PP), Accession No. Hs 437594(RPLP2), Accession No. Hs 437638(XBP1), Accession No. Hs 437779(C11orf10), Accession No. Hs 437831(C14orf32), Accession No. Hs 438072(UNC84A), Accession No. Hs 438219(GPS2), Accession No. Hs 438429(RPS19), Accession No. Hs 438678(TALDO1), Accession No. Hs 438720(MCM7), Accession No. Hs 438970(TBL1XR1), Accession No. Hs 438974(CUTL1), Accession No. Hs 439480(RBM5), Accession No. Hs 439481(SUPT4H1), Accession No. Hs 439548(FLJ22875), Accession No. Hs 439552, Accession No. Hs 439815(HBXIP), Accession No. Hs 440382(RFP), Accession No. Hs 440544(CLIC4), Accession No. Hs 440599(DDX1), Accession No. Hs 440604(PSMD7), Accession No. Hs 440899(TTYH3), Accession No. Hs 440932(SEPT9), Accession No. Hs 440960(RAD23A), Accession No. Hs 440961(CAST), Accession No. Hs 441072(POLR2L), Accession No. Hs 441550(C20orf22), Accession No. Hs 442344(IRS2), Accession No. Hs 442798(RNF10), Accession No. Hs 443134(GBA2), Accession No. Hs 443379(PSMD11), Accession No. Hs 443837(NPEPPS), Accession No. Hs 443914(SOD1), Accession No. Hs 444279(DKFZp761C169), Accession No. Hs 444356(GRB2), Accession No. Hs 444468(CTDSP1), Accession No. Hs 444472(SDHC), Accession No. Hs 444569(VMP1), Accession No. Hs 444673(CRR9), Accession No. Hs 444724(AZI2), Accession No. Hs 444818(CGGBP1), Accession No. Hs 444931(CRSP6), Accession No. Hs 444969(C2orf4), Accession No. Hs 444986(METAP2), Accession No. Hs 445081(NS5ATP13TP2), Accession No. Hs 445351(LGALS1), Accession No. Hs 445394(VPS29), Accession No. Hs 445498(SKIIP), Accession No. Hs 445511(RIOK3), Accession No. Hs 445570(CD63), Accession No. Hs 445803(DC2), Accession No. Hs 445893(KHDRBS1), Accession No. Hs 445977(GTF3A), Accession No. Hs 446017(WSB1), Accession No. Hs 446091(WTAP), Accession No. Hs 446123(CAPZA2), Accession No. Hs 446149(LDHB), Accession No. Hs 446260(PSMA6), Accession No. Hs 446336(PXN), Accession No. Hs 446345(FTH1), Accession No. Hs 446414(CD47), Accession No. Hs 446427(OAZ1), Accession No. Hs 446445(YIF1), Accession No. Hs 446450(ITM2B), Accession No. Hs 446574(TMSB10), Accession No. Hs 446588(RPS13), Accession No. Hs 446623(HNRPL), Accession No. Hs 446628(RPS4X), Accession No. Hs 446641(ARAF), Accession No. Hs 446852(EIF3S6IP), Accession No. Hs 447477(ST13), Accession No. Hs 447492(PGAM1), Accession No. Hs 447547(VPS35), Accession No. Hs 48226(RPLP0), Accession No. Hs 448588(NGFRAP1), Accession No. Hs 448646(RPL27A), Accession No. Hs 448879, Accession No. Hs 449114(HNRPC), Accession No. Hs 449171(HNRPK), Accession No. Hs 454534(USF2), Accession No. Hs 454699(IL6ST), Accession No. Hs 456507(PKD1-like), Accession No. Hs 456557(FLJ10597), Accession No. Hs 458320(DC12), Accession No. Hs 458358(TSPYL1), Accession No. Hs 458414(IFITM1), Accession No. Hs 458458(C19orf27), Accession No. Hs 458747(ANP32A), Accession No. Hs 459106(OAZIN), Accession No. Hs 459149(BTBD1), Accession No. Hs 459174(FLJ23790), Accession No. Hs 459211(AKAP13), Accession No. Hs 459596(MPG), Accession No. Hs 459649(CLCN7), Accession No. Hs 459927(PTMA), Accession No. Hs 459940(LITAF), Accession No. Hs 460238(SH3GLB2), Accession No. Hs 460317(ALS4), Accession No. Hs 460336(GGA2), Accession No. Hs 460468(XPO6), Accession No. Hs 460499(ATXN2L), Accession No. Hs 460574(LOC124446), Accession No. Hs 460923(CNOT1), Accession No. Hs 460929(GOT2), Accession No. Hs 460978(APPBP1), Accession No. Hs 461047(G6PD), Accession No. Hs 461131(CYB5-M), Accession No. Hs 461361(CFDP1), Accession No. Hs 461379(GABARAPL2), Accession No. Hs 461722(HSPC176), Accession No. Hs 461777(PCOLN3), Accession No. Hs 461896(CRK), Accession No. Hs 461925(RPA1), Accession No. Hs 462035(UBE2G1), Accession No. Hs 462086(RIP), Accession No. Hs 462306(UBE2S), Accession No. Hs 462316(TTC19), Accession No. Hs 462492(USP22), Accession No. Hs 462550(PIGS), Accession No. Hs 462956(PPARBP), Accession No. Hs 462998(IGFBP4), Accession No. Hs 463010(SMARCE1), Accession No. Hs 463035(FKBP10), Accession No. Hs 463041(RERE), Accession No. Hs 463059(STAT3), Accession No. Hs 463295(CDC27), Accession No. Hs 463506(AKAP1), Accession No. Hs 463702(BCAS3), Accession No. Hs 463797(C1orf33), Accession No. Hs 464071(PGD), Accession No. Hs 464137(ACOX1), Accession No. Hs 464210(SYNGR2), Accession No. Hs 464336(P4HB), Accession No. Hs 464438(AGTRAP), Accession No. Hs 464472(MRLC2), Accession No. Hs 464595(PPP4R1), Accession No. Hs 464652(TNFSF5IP1), Accession No. Hs 464912(P15RS), Accession No. Hs 465224(NARS), Accession No. Hs 465374(EFHD2), Accession No. Hs 465498(TXNL4A), Accession No. Hs 465529(MIDN), Accession No. Hs 465543(BTBD2), Accession No. Hs 465627(MAP2K2), Accession No. Hs 465645(C19orf10), Accession No. Hs 465808(HNRPM), Accession No. Hs 465849(PIN1), Accession No. Hs 465924(SDHB), Accession No. Hs 466044(PKN1), Accession No. Hs 466088(TPM4), Accession No. Hs 466148(NR2F6), Accession No. Hs 466471(GPI), Accession No. Hs 466693(SIRT2), Accession No. Hs 466766(LTBP4), Accession No. Hs 466775(SNRPA), Accession No. Hs 467084(EIF4G3), Accession No. Hs 467097(SNRP70), Accession No. Hs 467192(PPP2R1A), Accession No. Hs 467279(LENG4), Accession No. Hs 467284(RPS9), Accession No. Hs 467408(TRIM28), Accession No. Hs 467637(CDC42), Accession No. Hs 467696(HPCAL1), Accession No. Hs 467701(ODC1), Accession No. Hs 467807(LAPTM4A), Accession No. Hs 467824(PUM2), Accession No. Hs 467960(RAB10), Accession No. Hs 468018(PPP1CB), Accession No. Hs 468415(PIGF), Accession No. Hs 468442(CALM2), Accession No. Hs 468760(AFTIPHILIN), Accession No. Hs 469022(DGUOK), Accession No. Hs 469171(DKFZP564D0478), Accession No. Hs 469331(STARD7), Accession No. Hs 469820(RALB), Accession No. Hs 469863(YWHAZ), Accession No. Hs 469925(FLJ14346), Accession No. Hs 469970(SFRS4), Accession No. Hs 470091(YWHAE), Accession No. Hs 470233(ARL5), Accession No. Hs 470417, Accession No. Hs 470477(PTP4A2), Accession No. Hs 470577(EIF2S2), Accession No. Hs 470588(KPNA6), Accession No. Hs 470943(STAT1), Accession No. Hs 471011(SF3B1), Accession No. Hs 471104(NOP5/NOP58), Accession No. Hs 471207(NDUFS1), Accession No. 471441(PSMB2), Accession No. Hs 471461(ACSL3), Accession No. Hs 471593(CAB39), Accession No. Hs 471768(MGC4796), Accession No. Hs 471818(M11S1), Accession No. Hs 471851(HDLBP), Accession No. Hs 471873(DTYMK), Accession No. Hs 471933(FKBP1A), Accession No. Hs 471975(C20orf116), Accession No. Hs 472010(PRNP), Accession No. Hs 472024(C20orf30), Accession No. Hs 472031(UBE2D3), Accession No. Hs 472038(CGI-94), Accession No. Hs 472056(SYNCRIP), Accession No. Hs 472119(MKKS), Accession No. Hs 472185(NDUFS5), Accession No. Hs 472213(RRBP1), Accession No. Hs 472330(C20orf3), Accession No. Hs 472475(MACF1), Accession No. Hs 472535(AKIP), Accession No. Hs 472558(SDBCAG84), Accession No. Hs 472651(BLCAP), Accession No. Hs 472737(TOP1) Accession No. Hs 473296(TPD52L2), Accession No. Hs 473583(NSEP1), Accession No. Hs 473648(GART), Accession No. Hs 473721(SLC2A1), Accession No. Hs 473761(RTN3), Accession No. Hs 473788(OTUB1), Accession No. Hs 474005(SUMO3), Accession No. Hs 474010(PTTG1IP), Accession No. Hs 474053(COL6A1), Accession No. Hs 474083(B4GALT2), Accession No. Hs 474213(UFD1L), Accession No. Hs 474584(AKR1A1), Accession No. Hs 474643(HSPC117), Accession No. Hs 474751(MYH9), Accession No. Hs 474833(CSNK1E), Accession No. Hs 474914(RUTBC3), Accession No. Hs 474938(SLC25A17), Accession No. Hs 474949(RBX1), Accession No. Hs 474982(ACO2), Accession No. Hs 475125(ATXN10), Accession No. Hs 475319(LRRFIP2), Accession No. Hs 475382(FLJ22405), Accession No. Hs 475392(LOC55831), Accession No. Hs 475663(RAB5A), Accession No. Hs 475733(TOP2B), Accession No. Hs 475812(SIMP), Accession No. Hs 476018(CTNNB1), Accession No. Hs 476033(TLP19), Accession No. Hs 476179(SMARCC1), Accession No. Hs 476221(IHPK2), Accession No. Hs 76231(IMPDH2), Accession No. Hs 476308(ALAS1), Accession No. Hs 476365(SCP2), Accession No. Hs 476448(FLNB), Accession No. Hs 476706(MRPL37), Accession No. Hs 476930(DKFZP564O123), Accession No. Hs 477157(DULLARD), Accession No. Hs 477789(ATP1B3), Accession No. Hs 477892(GYG), Accession No. Hs 478000(MBNL1), Accession No. Hs 478044(PA2G4), Accession No. Hs 478553(EIF4A2), Accession No. Hs 479208(FBXL5), Accession No. Hs 479264(LAP3), Accession No. Hs 479634(SLC30A9), Accession No. Hs 479693(SFRS11), Accession No. Hs 479728(GAPD), Accession No. Hs 479747(BCAR1), Accession No. Hs 479814(POLR2B), Accession No. Hs 480073(HNRPD), Accession No. Hs 480311(PDLIM5), Accession No. Hs 480465(SCYE1), Accession No. Hs 80653(ANXA5), Accession No. Hs 481571(UQCRH), Accession No. Hs 481720(MYO10), Accession No. Hs 481898(KAT3), Accession No. Hs 482144(RPL26), Accession No. Hs 482363(SLC30A5), Accession No. Hs 482526(TINP1), Accession No. Hs 482868(KIAA0372), Accession No. Hs 483036(PJA2), Accession No. Hs 483067(C50orf13), Accession No. Hs 483305(HINT1), Accession No. Hs 483408(PPP2CA), Accession No. Hs 483454(CNN3), Accession No. Hs 483486(JMJD1B), Accession No. Hs 484138(FBXW11), Accession No. Hs 484188(ATP6V0E), Accession No. 484242(ETEA), Accession No. Hs 484288(DDX41), Accession No. Hs 484363(RNF130), Accession No. Hs 484551(CPM), Accession No. Hs 484813(DEK), Accession No. Hs 485155(RPL35), Accession No. Hs 485195(SORT1), Accession No. Hs 485246(PSMA5), Accession No. Hs 485262(MTCH1), Accession No. Hs 485365(AHCYL1), Accession No. Hs 485616(DST), Accession No. Hs 486542(BCLAF1), Accession No. Hs 487027(VIL2), Accession No. Hs 487054(TCP1), Accession No. Hs 487635(BZW2), Accession No. Hs 487774(HNRPA2B1), Accession No. Hs 488171(KIAA1068), Accession No. Hs 488181(OGDH), Accession No. Hs 488307(DKFZP564K0822), Accession No. Hs 488478(FLJ10099), Accession No. Hs 488671(BAZ1B), Accession No. Hs 489207(ASNS), Accession No. Hs 489284(ARPC1B), Accession No. Hs 489287(CPSF4), Accession No. Hs 489336(SYAP1), Accession No. Hs 489615(PBEF1), Accession No. Hs 490203(CALD1), Accession No. Hs 490394(SSBP1), Accession No. Hs 490415(ZYX), Accession No. Hs 490745(DNAJB6), Accession No. Hs 490795(CHR2SYT), Accession No. Hs 490874(MTX1), Accession No. Hs 491336(ELP3), Accession No. Hs 491359(LMNA), Accession No. Hs 491440(PPP2CB), Accession No. Hs 491494(CCT3), Accession No. Hs 491597(VDAC3), Accession No. Hs 491695(UBE2V2), Accession No. Hs 491745(TCEA1), Accession No. Hs 491988(TRAM1), Accession No. Hs 492236(WDR42A), Accession No. Hs 492314(LAPTM4B), Accession No. Hs 492445(EDD), Accession No. Hs 492599(EIF3S3), Accession No. Hs 492805(CGI-07), Accession No. Hs 493362(AK3L1), Accession No. Hs 493750(WDR40A), Accession No. Hs 494173(ANXA1), Accession No. Hs 494419(LAMP1), Accession No. Hs 494457(NINJ1), Accession No. Hs 494604(ANP32B), Accession No. Hs 494614(XTP2), Accession No. Hs 494691(PFN1), Accession No. Hs 494700(CDW92), Accession No. Hs 494985(FBXW2), Accession No. Hs 495039(NDUFA8), Accession No. Hs 495349(KIAA0515), Accession No. Hs 495471(PMPCA), Accession No. Hs 495605(CD99), Accession No. Hs 495851 (MGC4825), Accession No. Hs 495960(ATP6AP2), Accession No. Hs 496068(PCTK1), Accession No. Hs 496098(DKFZp761A052), Accession No. Hs 496271, Accession No. Hs 496487(ATF4), Accession No. Hs 496646(IL13RA1), Accession No. Hs 496684(LAMP2), Accession No. Hs 497183(IVNS1ABP), Accession No. Hs 497599(WARS), Accession No. Hs 497692(C1orf48), Accession No. Hs 497893(ENAH), Accession No. Hs 498239(FH), Accession No. Hs 498313(ADSS), Accession No. Hs 498317(PNAS-4), Accession No. Hs 498455(KIAA0217), Accession No. Hs 498548(RBM17), Accession No. Hs 498727(DHCR24), Accession No. Hs 499145(YME1L1), Accession No. Hs 499158(GGA1), Accession No. Hs 499594(TIMM23), Accession No. Hs 499833(C10orf74), Accession No. Hs 499891(HNRPH3), Accession No. Hs 499925(VPS26), Accession No. Hs 499960(SARA1), Accession No. Hs 500067(PPP3CB), Accession No. Hs 500101(VCL), Accession No. Hs 500375(ENTPD6), Accession No. Hs 500409(GLUD1), Accession No. Hs 500546(IDE), Accession No. Hs 500674(SMBP), Accession No. Hs 500775(ZNF207), Accession No. Hs 500842(MGEA5), Accession No. Hs 500874(CUEDC2), Accession No. Hs 501012(ADD3), Accession No. Hs 501023(MXI1), Accession No. Hs 501203(TIAL1), Accession No. Hs 501293(BSG), Accession No. Hs 501309(CIRBP), Accession No. Hs 501353(PLEKHJ1), Accession No. Hs 501376(UROS), Accession No. Hs 501420(NCLN), Accession No. Hs 501629(IER2), Accession No. Hs 501684(NAP1L4), Accession No. Hs 501735(STIM1), Accession No. Hs 501853(C11orf15), Accession No. Hs 501924(USP47), Accession No. Hs 501991(MLSTD2), Accession No. Hs 502302(CAT), Accession No. Hs 502328(CD44), Accession No. Hs 502461(DGKZ), Accession No. Hs 502528(NDUFS3), Accession No. Hs 502630(C11orf31), Accession No. Hs 502659(RHOC), Accession No. Hs 502705(PRP19), Accession No. Hs 502745(FADS2), Accession No. Hs 502769(SLC3A2), Accession No. Hs 502773(MTCBP-1), Accession No. Hs 502823(PRDX5), Accession No. Hs 502829(SF1), Accession No. Hs 502836(ARL2), Accession No. Hs 502842(CAPN1), Accession No. Hs 502872(MAP3K11), Accession No. Hs 502876(RHOB), Accession No. Hs 503093(ZFP36L2), Accession No. Hs 503222(RAB6A), Accession No. Hs 503251(PME-1), Accession No. Hs 503597(HSPC148), Accession No. Hs 503709(PORIMIN), Accession No. Hs 503716(MGC2714), Accession No. Hs 503787(DARS), Accession No. Hs 504237(ITM1), Accession No. Hs 504517(RPS27), Accession No. Hs 504613(PTMS), Accession No. Hs 504620(REA), Accession No. Hs 504687(MYL9), Accession No. Hs 504828(DDX47), Accession No. Hs 504895(STRAP), Accession No. Hs 505033(KRAS2), Accession No. Hs 505059(PSMD4), Accession No. Hs 505625(C12orf10), Accession No. Hs 505652(COPZ1), Accession No. Hs 505676(CIP29), Accession No. Hs 505705(MYL6), Accession No. Hs 505806(PBXIP1), Accession No. Hs 505824(CGI-51), Accession No. Hs 506215(RARS), Accession No. Hs 506325(NUDT4), Accession No. Hs 06759(ATP2A2), Accession No. Hs 506861(DDX54), Accession No. Hs 507074(KIAA0152), Accession No. Hs 507162(FLJ12750), Accession No. Hs 507584(MGC9850), Accession No. Hs 507680(PFAAP5), Accession No. Hs 507910(PGRMC2), Accession No. Hs 507916(TGFB1I4), Accession No. Hs 508010(FNDC3A), Accession No. Hs 508644(FLJ10154), Accession No. Hs 509163(KIAA1181), Accession No. Hs 509226(FKBP3), Accession No. Hs 509264(KLHDC2), Accession No. Hs 509414(KTN1), Accession No. Hs 509622(RGL2), Accession No. Hs 509736(HSPCB), Accession No. Hs 509791(ERH), Accession No. Hs 509909(NUMB), Accession No. Hs 510087(ENSA), Accession No. Hs 510328(DDX24), Accession No. Hs 510402(MCP), Accession No. Hs 511067(FLJ10579), Accession No. Hs 511138(DKFZP564G2022), Accession No. Hs 511149(SNAP23), Accession No. Hs 511425(SRP9), Accession No. Hs 511504(TCF12), Accession No. Hs 511862, Accession No. Hs 511952(CBX6), Accession No. Hs 512005(ARPC3), Accession No. Hs 512465(SURF4), Accession No. Hs 512525(RPS17), Accession No. Hs 512607(MIR16), Accession No. Hs 512640(PRKCSH), Accession No. Hs 512661(KIAA1160), Accession No. Hs 512676, Accession No. Hs 512693(FLJ20859), Accession No. Hs 512756(THAP7), Accession No. Hs 512815(AP3D1), Accession No. Hs 512857(CD151), Accession No. Hs 512867(H63), Accession No. Hs 512908(ARPP-19), Accession No. Hs 513043(C15orf12), Accession No. Hs 513055(REC14), Accession No. Hs 513057(RANBP5), Accession No. Hs 513058(TMED3), Accession No. Hs 513071(MESDC1), Accession No. Hs 513083(RPL9), Accession No. Hs 513141(IDH2), Accession No. Hs 513145(NEUGRIN), Accession No. Hs 513153(FURIN), Accession No. Hs 513230(MRPL28), Accession No. Hs 513242(RHOT2), Accession No. Hs 513261(C16orf34), Accession No. Hs 513266(NDUFB10), Accession No. Hs 513470(NFATC2IP), Accession No. Hs 513488(MVP), Accession No. Hs 513490(ALDOA), Accession No. Hs 513520(BCKDK), Accession No. Hs 513522(FUS), Accession No. Hs 513631(ARL2BP), Accession No. Hs 513856(DPH2L1), Accession No. Hs 513984(FLII), Accession No. Hs 514012(MAP2K3), Accession No. Hs 514036(SDF2), Accession No. Hs 514038(FLOT2), Accession No. Hs 514174(JUP), Accession No. Hs 514196(RPL27), Accession No. Hs 514211(MGC4251), Accession No. Hs 514216(CGI-69), Accession No. Hs 514220(GRN), Accession No. Hs 514297(FLJ13855), Accession No. Hs 514303(PHB), Accession No. Hs 514435(SF3B3), Accession No. Hs 514489(WBP2), Accession No. Hs 514535(LGALS3BP), Accession No. Hs 514581(ACTG1), Accession No. Hs 514590(HGS), Accession No. Hs 514819(AP2B1), Accession No. Hs 514870(ATP5F1), Accession No. Hs 514920(NDP52), Accession No. Hs 514934(CAPZA1), Accession No. Hs 515003(C19orf6), Accession No. Hs 515005(STK11), Accession No. Hs 515018(GNA13), Accession No. Hs 515053(AES), Accession No. Hs 515070(EEF2), Accession No. Hs 515092(CLPP), Accession No. Hs 515155(MGC2803), Accession No. Hs 515162(CALR), Accession No. Hs 515164(GADD45GIP1), Accession No. Hs 515210(DNAJB1), Accession No. Hs 515255(LSM4), Accession No. Hs 515266(RENT1), Accession No. Hs 515271(SFRS14), Accession No. Hs 515329(RPL22), Accession No. Hs 515371(CAPNS1), Accession No. Hs 515406(AKT2), Accession No. Hs 515417(EGLN2), Accession No. Hs 515432(DEDD2), Accession No. Hs 515472(SNRPD2), Accession No. Hs 515475(SYMPK), Accession No. Hs 515487(CALM3), Accession No. Hs 515494(SLC1A5), Accession No. Hs 515500(SAE1), Accession No. Hs 515515(KDELR1), Accession No. Hs 515517(RPL18), Accession No. Hs 515524(NUCB1), Accession No. Hs 515540(PTOV1), Accession No. Hs 515550(LOC284361), Accession No. Hs 515598(PRPF31), Accession No. Hs 515607(PPP1R12C), Accession No. Hs 515642(GPSN2), Accession No. Hs 515785(BLVRB), Accession No. Hs 515846(RUVBL2), Accession No. Hs 515848(HADHB), Accession No. Hs 515890(YPEL5), Accession No. Hs 516075(TIA1), Accession No. Hs 516077(FLJ14668), Accession No. Hs 516087(TEX261), Accession No. Hs 516111(DCTN1), Accession No. Hs 516114(WBP1), Accession No. Hs 516157(MAT2A), Accession No. Hs 516450(FLJ20297), Accession No. Hs 516522(FLJ21919), Accession No. Hs 516539(HNRPA3), Accession No. Hs 516587(UBE2Q), Accession No. Hs 516633(NCKAP1), Accession No. Hs 516711(CHPF), Accession No. Hs 516790(ARHGEF2), Accession No. Hs 516807(STK25), Accession No. Hs 516826(TRIB3), Accession No. Hs 516855(CENPB), Accession No. Hs 517080(SLC35C2), Accession No. Hs 517106(CEBPB), Accession No. Hs 517134(C20orf43), Accession No. Hs 517145(ENO1), Accession No. Hs 517168(TAGLN2), Accession No. Hs 517216(PEA15), Accession No. Hs 517232(PEX19), Accession No. Hs 517240(IFNGR2), Accession No. Hs 517262(SON), Accession No. Hs 517293(F11R), Accession No. Hs 517338(ATP6V1E1), Accession No. Hs 17342(DEDD), Accession No. Hs 517356(COL18A1), Accession No. Hs 517357(DGCR2), Accession No. Hs 517421(PCQAP), Accession No. Hs 517438(ASCC2), Accession No. Hs 517517(EP300), Accession No. Hs 517543(PES1), Accession No. Hs 517582(MCM5), Accession No. Hs 517622(UNC84B), Accession No. Hs 517641(L3 MBTL2), Accession No. Hs 517666(DIA1), Accession No. Hs 517731(PP2447), Accession No. Hs 517768(DKFZP564B167), Accession No. Hs 517792(C3orf10), Accession No. Hs 517817(MGC3222), Accession No. Hs 517821, Accession No. Hs 517888(CRTAP), Accession No. Hs 517948(DHX30), Accession No. Hs 517949(MAP4), Accession No. Hs 517969(APEH), Accession No. Hs 517981(TUSC2), Accession No. Hs 518060(ARL6IP5), Accession No. Hs 518123(TFG), Accession No. Hs 518236(SEC61A1), Accession No. Hs 518244(RPN1), Accession No. Hs 518249(ZNF9), Accession No. Hs 518250(COPG), Accession No. Hs 518265(H41), Accession No. Hs 518326(SERP1), Accession No. Hs 518346(SSR3), Accession No. Hs 518374(QSCN6), Accession No. Hs 518424(NDUFB5), Accession No. Hs 518460(AP2M1), Accession No. Hs 518464(PSMD2), Accession No. Hs 518525(GLUL), Accession No. Hs 518551(RPL31), Accession No. Hs 518608(PP784), Accession No. Hs 518609(ARPC5), Accession No. Hs 518750(OCIAD1), Accession No. Hs 18805(HMGA1), Accession No. Hs 518827(CCNI), Accession No. Hs 519276(MAPKAPK2), Accession No. Hs 519304(PELO), Accession No. Hs 519346(ERBB2IP), Accession No. Hs 519347(SFRS12), Accession No. Hs 519520(RPS25), Accession No. Hs 519523(SERPINB6), Accession No. Hs 519557(TMEM14C), Accession No. Hs 519718(TTC1), Accession No. Hs 519756(STK10), Accession No. Hs 519818(MGAT1), Accession No. Hs 519909(MARCKS), Accession No. Hs 519930(C6orf62), Accession No. Hs 520026(VARS2), Accession No. Hs 520028(HSPA1A), Accession No. Hs 520037(NEU1), Accession No. Hs 520070(C6orf82), Accession No. Hs 520140(SRF), Accession No. Hs 520189(ELOVL5), Accession No. Hs 520205(EIF2AK1), Accession No. Hs 520210(KDELR2), Accession No. Hs 520287(C6orf111), Accession No. Hs 520313(CD164), Accession No. Hs 520383(STX7), Accession No. Hs 520421(PERP), Accession No. Hs 520459(GTF2I), Accession No. Hs 520623(C7orf27), Accession No. Hs 520640(ACTB), Accession No. Hs 520740(SCRN1), Accession No. Hs 520794(YKT6), Accession No. Hs 520898(CTSB), Accession No. Hs 520943(WBSCR1), Accession No. Hs 520967(MDH2), Accession No. Hs 520973(HSPB1), Accession No. Hs 520974(YWHAG), Accession No. Hs 521064(ZNF655), Accession No. Hs 521151(FLJ22301), Accession No. Hs 521289(REPIN1), Accession No. Hs 521487(MGC8721), Accession No. Hs 521640(RAD23B), Accession No. Hs 521809(COBRA1), Accession No. Hs 521903(LY6E), Accession No. Hs 521924(SIAHBP1), Accession No. Hs 521969(NDUFB11), Accession No. Hs 521973(WDR13), Accession No. Hs 522074(DSIPI), Accession No. Hs 522110(CREB3), Accession No. Hs 522114(CLTA), Accession No. Hs 522310(NANS), Accession No. Hs 522373(GSN), Accession No. Hs 522394(HSPA5), Accession No. Hs 522463(EEF1A1), Accession No. Hs 522507(FBXW5), Accession No. Hs 522584(TMSB4X), Accession No. Hs 522590(EIF1AX), Accession No. Hs 522632(TIMP1), Accession No. Hs 522665(MAGED2), Accession No. Hs 522675(FLJ12525), Accession No. Hs 522752(PSMD10), Accession No. Hs 522817(BCAP31), Accession No. Hs 522819(IRAK1), Accession No. Hs 522823(EMD), Accession No. Is 522932(NCOA4), Accession No. Hs 522995(EIF4EBP2), Accession No. Hs 523004(PSAP), Accession No. Hs 523012(DDIT4), Accession No. Hs 523054(SMP1), Accession No. Hs 523131(TRAPPC3), Accession No. Hs 523145(DDOST), Accession No. Hs 523215(NDUFB8), Accession No. Hs 523238(NOLC1), Accession No. Hs 523262(C1orf8), Accession No. Hs 523299(EIF3S10), Accession No. Hs 523302(PRDX3), Accession No. Hs 523560(HSPCA), Accession No. Hs 523680(SSRP1), Accession No. Hs 523789(TncRNA), Accession No. Hs 523829(POLD4), Accession No. Hs 523836(GSTP1), Accession No. Hs 523852(CCND1), Accession No. Hs 523875(INPPL1), Accession No. Hs 524009(AASDHPPT), Accession No. Hs 524081(DPAGT1), Accession No. Hs 524084(RNF26), Accession No. Hs 524161(RSU1), Accession No. Hs 524171(RAD52), Accession No. H1s 524183(FKBP4), Accession No. Hs 524195(ARHGAP21), Accession No. Hs 524214(MLF2), Accession No. Hs 524219(TPI1), Accession No. Hs 524271(PHC2), Accession No. Hs 524367(CBARA1), Accession No. Hs 524395(TUBA3), Accession No. Hs 524464(ATP5G2), Accession No. Hs 524502(RNF41), Accession No. Hs 524530(CTDSP2), Accession No. Hs 524590(RAB21), Accession No. Hs 524599(NAP1L1), Accession No. Hs 524690(PPIE), Accession No. Hs 524788(RAB35), Accession No. Hs 524809(RSN), Accession No. Hs 524899(SAP18), Accession No. Hs 524920(ZFP91), Accession No. Hs 524969(Ufm1), Accession No. Hs 525134(FLJ20277), Accession No. Hs 525163(ANKRD10), Accession No. Hs 525232(LRP10), Accession No. Hs 525238(C14orf119), Accession No. Hs 525330(ARF6), Accession No. Hs 525391(FLJ20580), Accession No. Hs 525527(RER1), Accession No. Hs 525626(PACS1L), Accession No. Hs 525899(C6orf49), Accession No. Hs 526464(PML), Accession No. Hs 526521(MDH1), Accession No. Hs 527105(HNRPDL), Accession No. Hs 527193(RPS23), Accession No. Hs 527348(AKAP9), Accession No. Hs 527412(ASAH1), Accession No. Hs 527861(OS-9), Accession No. Hs 527862(PKD1), Accession No. Hs 527980(DUT), Accession No. Hs 528050(HARS), Accession No. Hs 528222(NDUFS4), Accession No. Hs 528300(PITRM1), Accession No. Hs 528305(DDX17), Accession No. Hs 528572(SCAM-1), Accession No. Hs 528668(RPL6), Accession No. Hs 528780(GSPT1), Accession No. Hs 528803(UQCRC2), Accession No. Hs 529059(EIF3S4), Accession No. Hs 529132(SEPW1), Accession No. Hs 529244(NCK2), Accession No. Hs 529280(ANAPC7), Accession No. Hs 529303(ARPC2), Accession No. Hs 529369(AFAP), Accession No. Hs 529400(IFNAR1), Accession No. Hs 529420(UBE2G2), Accession No. Hs 529591(TLOC1), Accession No. Hs 529618(TFRC), Accession No. Hs 529631(RPL35A), Accession No. Hs 529782(VCP), Accession No. Hs 529798(BTF3), Accession No. Hs 529862(CSNK1A1), Accession No. 1s 529890(CANX), Accession No. Hs 529892(SQSTM1), Accession No. Hs 529957(SEC63), Accession No. Hs 530096(EIF3S2), Accession No. Hs 530118(LUC7L2), Accession No. Hs 530291(ANXA11), Accession No. Hs 530314(SSNA1), Accession No. Hs 530331(PDHA1), Accession No. Hs 530381(PIM3), Accession No. Hs 530412(PAI-RBP1), Accession No. Hs 530436(STXBP3), Accession No. Hs 530479(PMF1), Accession No. Hs 530687(RNH), Accession No. Hs 530734(MRPL16), Accession No. Hs 530753(FLJ20625), Accession No. Hs 530823(COPS7A), Accession No. Hs 530862(PRKAG1), Accession No. Hs 531081(LGALS3), Accession No. Hs 531089(PSMA3), Accession No. Hs 531176(SARS), Accession No. Hs 531330(CBWD1), Accession No. Hs 531614(BTBD14B), Accession No. Hs 531752(RANBP3), Accession No. Hs 531856(GAS5), Accession No. Hs 531876(DNCL2A), Accession No. Hs 531879(RAD1), Accession No. Hs 532359(RPL5), Accession No. Hs 532399(KIAA0663), Accession No. Hs 532755(GTL3), Accession No. Hs 532790(NMT1), Accession No. Hs 532793(KPNB1), Accession No. Hs 532803(HN1), Accession No. Hs 532826(MCL1), Accession No. Hs 532853(NDUFB7), Accession No. Hs 533030(HRIHFB2122), Accession No. Hs 533059(TUBB), Accession No. Hs 533122(SFRS10), Accession No. Hs 533136(LRPAP1), Accession No. Hs 533192(TOMM20), Accession No. Hs 533222(HSA9761), Accession No. Hs 533245(DDX46), Accession No. Hs 533282(NONO), Accession No. Hs 533308(PPP2R5D), Accession No. Hs 533317(VIM), Accession No. Hs 533437(TCEB1), Accession No. Hs 533440(WWP1), Accession No. Hs 533474(PPP1R8), Accession No. Hs 533479(LYPLA2), Accession No. Hs 533526(ATRX), Accession No. Hs 533624(H3F3A), Accession No. Hs 533712(RBM4), Accession No. Hs 533732(SRP14), Accession No. Hs 533771(STUB1), Accession No. Hs 533782(KRT8), Accession No. Hs 533977(TXNIP), Accession No. Hs 533985(EXOC7), Accession No. Hs 533986(ZNF258), Accession No. Hs 534125(HLA-C), Accession No. Hs 534168(NDUFA1), Accession No. Hs 534212(SEC22L1), Accession No. Hs 534255(B2M), Accession No. Hs 534307(CCND3), Accession No. Hs 534314(EIF5A), Accession No. Hs 534326(ITGB4BP), Accession No. Hs 534338(PPP4C), Accession No. Hs 534346(RPS7), Accession No. Hs 534350(SMARCB1), Accession No. Hs 534453(GRIM19), Accession No. Hs 534456(ANAPC11), Accession No. Hs 534457(C14orf66), Accession No. Hs 534473(TOMM22), Accession No. Hs 534483(MGC2941), Accession No. Hs 536275(PACS1), Accession No. Hs 541269(NDUFB9), Accession No. Hs 546248(CTSD), Accession No. Hs 546250(DNCI2), Accession No. Hs 546253(FDFT1), Accession No. Hs 546261(HNRPA1), Accession No. Hs 546269(RPL10A), Accession No. Hs 546271(PCBP2), Accession No. Hs 546286(RPS3), Accession No. Hs 546289(RPS12), Accession No. Hs 546290(RPS18), Accession No. Hs 546291(NET-5), Accession No. Hs 546339(SMAP), Accession No. Hs 546356(RPL13A), Accession No. Hs 546394(HSPC016), Accession No. Hs 547759(SSBP3), Accession No. Hs 549178(C9orf86), Accession No. Hs 552590(HTF9C), Accession No. Hs 553496(PGM3), Accession No. Hs 553512(C3F), Accession No. Hs 554767(NUP88), Accession No. Hs 554776(SREBF1), Accession No. Hs 554894(FLJ12953), Accession No. Hs 554896(MGC11257), Accession No. Hs 555194(FAM36A), Accession No. Hs 555866(C1QBP), Accession No. Hs 555873(HNRPAB), Accession No. Hs 555875(IDH3A), Accession No. Hs 555889(PSMC2), Accession No. Hs 555890(RBBP4), Accession No. Hs 555911(RBM8A), Accession No. Hs 555969(RIC8), Accession No. Hs 555971(PP1201), Accession No. Hs 555973(MRPS25), Accession No. Hs 555994(LONP), Accession No. Hs 556267(FBXL10), Accession No. Hs 556461(NDUFV2), Accession No. Hs 556795(PAICS), Accession No. Hs 557550(NPM1), Accession No. Hs 558296(ACP1), Accession No. Hs 558313(COX6A1), Accession No. Hs 558322(EEF1B2), Accession No. Hs 558325(EIF5), Accession No. Hs 558328(FKBP5), Accession No. Hs 558330(FTL), Accession No. Hs 558338(HSPE1), Accession No. Hs 558345(IK), Accession No. Hs 558354(LAMR1), Accession No. Hs 558360(NDUFB4), Accession No. Hs 558361(NME2), Accession No. Hs 558362(NUMA1), Accession No. Hs 558376(RAC1), Accession No. Hs 558381(RNU65), Accession No. Hs 558382(RPL15), Accession No. Hs 558383(RPL18A), Accession No. Hs 558384(RPL19), Accession No. Hs 558385(RPL23A), Accession No. Hs 558386(RPL34), Accession No. Hs 558388(RPS3A), Accession No. Hs 558389(RPS8), Accession No. Hs 558390(RPS24), Accession No. Hs 558391(RPS26), Accession No. Hs 558396(SCD), Accession No. Hs 558424(CSDA), Accession No. Hs 558426(EIF3S5), Accession No. Hs 558429(G10), Accession No. Hs 558431(RPL14), Accession No. Hs 558442(PDCD61P), Accession No. Hs 558448(TXNL2), Accession No. Hs 558453(ATP5L), Accession No. Hs 558454(NUDC), Accession No. Hs 558458(COPS8), Accession No. Hs 558473(C18orf10), Accession No. Hs 558499(8D6A), Accession No. Hs 558511(PSARL), Accession No. Hs 558521(C2orf33), Accession No. Hs 558591(ORMDL1), Accession No. Hs 558825(PDE4DIP), Accession No. Hs 558995, Accession No. Hs 567260(CD2BP2), Accession No. Hs 567263(C1orf43), Accession No. Hs 567267(ATP2C1) and Accession No. Hs 567279(HCNGP). According to the present invention, the detection reagent is a pair of primers and/or probes applicable to the amplification of the candidate reference gene.
Suitable for use in the composition of the present invention is a pair of a sense primer and an antisense primer, both ranging in length from 10 to 50 bp, corresponding to a sense or antisense sequence of the selected candidate reference gene, respectively. The sense primer is preferably 12 ̃30 bp, more preferably 15 ̃26 bp, and most preferably 17 ̃22 bp in length. This is also true of the antisense primer. However, as long as they are useful in the amplification of the gene, the primers used in the present invention can be any length. The primers may be designed using a well-known primer design program. Additionally, the primers are not limited as to their position on the gene, as long as they can be used in the amplification of the gene.
In contrast to previously reported traditional HKGs, in which genes encoding metabolism and ribosome proteins are contained in high proportions (Eisenberg E & Levanon E Y, Trends Genet 19:362-5, 2003; Hsiao L L et al., Physiol Genomics 7:97-104, 2001), genes encoding proteins involved in protein fate (23%, 308/1318) and cellular transport (21%, 273/1318) are found at a high proportion within the candidate ERGs when they are classified by FunCat (Functional Classification Catalogue, Version 2.0, Ruepp A et al., Nucleic Acids Res 32:5539-45, 2004) (see FIG. 2). Further, analysis on the 2,087 genes shows a high frequency of CpG islands, which is in line with the results of previous reports (Larsen F et al., Genomics 13:1095-107, 1992; Ponger L et al., Genome Res 1.1:1854-60, 2001) (see TABLE 1).
Moreover, the genes can be detected using microarray, SAGE (Serial Analysis of Gene Expression) or qRT-PCR (quantitative real time PCR). Out of the genes, the most abundant transcript was found to come from EEF1A1 in EST and LongSAGE, from DGK1 in ShortSAGE, and from RPL10A in HG-U133 microarray (see Table 2).
In addition, the reference genes selected and identified according to the present invention are adopted as candidate reference genes which may be useful in the analysis of the genes of interest through the validation of expression stability.
In accordance with a further aspect thereof, the present invention provides a method for quantifying an expression level of a gene of interest, comprising:
1) performing real-time PCR to amplify the gene of interest with a pair of primers and/or probes and then performing real-time PCR to amplify the candidate endogenous reference gene with the composition; and
2) normalizing the expression level of the gene of interest relative to that of the candidate endogenous reference gene.
In accordance with still a further aspect thereof, the present invention provides a method for selecting guide genes, comprising measuring the selected candidate endogenous reference genes for coefficient of variation (CV) and ranking the endogenous reference genes in an ascending order of CV.
In an embodiment, the guide genes are expressed in most human body tissues. The guide genes can be used to normalize expression levels for relative quantification of gene expression between different samples. The higher the coefficient of variation (CV) is, the more greatly the gene expression varies from one tissue to another.
CVs of the candidate reference genes, selected using the selection method of the present invention, were calculated for each UniGene cluster in the datasets including EST, ShortSAGE, LongSAGE and microarray, and the genes were arranged in ascending order of CV. From the candidate ERG were selected the reference genes which were found to be stably expressed across a wide range of tissues. Out of the 400 genes (corresponding to about 20% of the candidate ERG) which were preferentially ranked in ascending order of CV from each dataset, 13 ERGs common to all four datasets were selected (see FIG. 1 and Table 3). The 13 reference genes are identified as Accession No. Hs 500775(ZNF207), Accession No. Hs 446427(OAZ1), Accession No. Hs 530118(LUC7L2), Accession No. Hs 208597(CTBP1), Accession No. Hs 440382(TRIM27), Accession No. Hs 444279(GPBP1), Accession No. Hs 250009(ARL8B), Accession No. Hs 9589(UBQLN1), Accession No. Hs 253726(PAPOLA), Accession No. Hs 146806(CUL1), Accession No. Hs 533222(DIMT1L), Accession No. Hs 494985(FBXW2) and Accession No. Hs 242458(SPG21).
In other words, the reference genes are genes that show lower expression variations than do the other genes among the 2,087 genes expressed in most tissues. The reference genes identified according to the present invention are expressed in a manner similar to that in which the majority of the intracellular transcripts are expressed at low abundance.
In an aspect of gene expression level and CV, the 13 reference genes identified according to the present invention were compared with 13 traditional reference genes (see Table 4). In all datasets, six of the 13 traditional reference genes showed relatively high mean expression levels, while the other traditional reference genes indicated expression levels similar to or lower than those of the reference genes of the present invention. In terms of both expression level and CV, the traditional reference genes are generally greater than the endogenous reference genes of the present invention (see FIGS. 6 and 7).
In order to validate the suitability of the 13 genes for reference genes, they were examined for gene copy number variation with reference to the Database of Genomic Variants(//projects.tcag.ca/variation/)(see Table 5). As a result, only OAZ1 and DIMT1L, among the 13 genes of the present invention, were found on chromosome regions known for gene copy variation, whereas many (ACTB, GAPDH, PGK1, B2M, TBP, TFRC, ALAS1) of the traditional reference genes were located in such chromosome regions.
Furthermore, the quantitative real-time RT-PCR (qRT-PCR) analysis (see Table 7) of ERG on human tissue samples and cancer cell lines (see Table 6) indicated that the 13 novel ERGs were expressed in all 48 samples, including frozen human tissues and cancer cell lines (see FIG. 8). The novel 13 ERGs ranged from 19 to 29 in Cp (Crossing Point, the cycle number at which fluorescence crosses the background signal upon qRT-PCR) (see FIG. 9). In addition, using geNorm v 3.4 software (Vandesompele J et al., Genome Biol 3:RESEARCH0034, 2002) and NormFinder software (Andersen C L et al., Cancer Res 64:5245-50, 2004), ERGs were analyzed for expression stability according to the following Mathematical Formula 4 in consideration of the efficiency of the PCR performed above (see Table 8). All of the 13 novel ERGs according to the present invention were found to show higher expression stability than were the traditional ERGs as calculated by the geNorm and NormFinder programs (see Table 9). In Table 9, lower expression stability values (M by geNorm, S by NormFinder) mean more stable expression.

Relative Expression=(1+E)ΔCp  <Mathematical Formula 4>

    
    
        ΔCp=Minimum Cp−Sample Cp;
        Minimum Cp=lowest Cp value; and
        E=PCR Efficiency
    
    


There was no significant correlation between the M values, which were calculated with geNorm (M) and CV in microarray and LongSAGE datasets, but significance was found in EST and ShortSAGE datasets. Likewise, as for the stability values(S), calculated with NormFinder, significant correlation was found in EST, ShortSAGE and LongSAGE, but not in microarray. Both the M and the S values showed highest agreement with CV in ShortSAGE (see Table 10).
These results indicate that the reference genes identified according to the present invention are more stably expressed than are the traditional reference genes.
In consideration of the fact that the majority of intracellular transcripts are expressed in low abundance (Warrington J A et al., Physiol Genomics 2(3):143-147, 2000), traditional reference genes, having high expression levels, may not be suitable for use in normalization. A reference gene with an expression level similar to that of a target gene is recommended, so that the measurement can be done on the same linear scale (Szabo A et al., Genome Biol 5(8):R59, 2004; RocheAppliedScience Technical Note No. LC 15/2005). Therefore, the endogenous reference genes identified according to the present invention are believed to be more suitable and widely used because they show relatively lower expression and lower variability than do the traditional reference genes (Czechowski T et al., Plant Physiol 139(1):5-17, 2005).
In accordance with still another aspect thereof, the present invention provides a composition for detecting at least one of the guide genes identified according to the present invention, comprising a detection reagent applicable to amplification of the guide gene.
In an embodiment of this aspect, the guide genes feature low expression levels, like most low-abundance intracellular transcripts. The guide gene useful in the present invention is one or more genes selected from a group consisting of Accession No. Hs 500775(ZNF207), Accession No. Hs 446427(OAZ1), Accession No. Hs 530118(LUC7L2), Accession No. Hs 208597(CTBP1), Accession No. Hs 440382(TRIM27), Accession No. Hs 444279(GPBP1), Accession No. Hs 250009(ARL8B), Accession No. Hs 9589(UBQLN1), Accession No. Hs 253726(PAPOLA), Accession No. Hs 146806(CUL1), Accession No. Hs 533222(DIMT1L), Accession No. Hs 494985(FBXW2) and Accession No. Hs 242458(SPG21). According to the present invention, the detection reagent is a pair of primers and/or probes applicable to the amplification of the guide gene.
Suitable for use in the composition of the present invention is a pair of a sense primer and an antisense primer, both ranging in length from 10 to 50 bp corresponding to sense or antisense sequence of the identified guide genes, respectively. The sense primer is preferably 12 ̃30 bp, more preferably 15 ̃26 bp, and most preferably 17 ̃22 bp in length. This is also true of the antisense primer. However, as long as they are useful in the amplification of the gene, any length of primers can be used in the present invention. The primers may be designed using a well-known primer design program. Additionally, the primers are not limited by the position on the gene as long as they can be used in the amplification of the gene.
In addition, the detection method is preferably conducted using microarray, SAGE (Serial Analysis of Gene Expression) or qRT-PCR (quantitative real time PCR).
In accordance with yet a further aspect thereof, the present invention provides a method for quantifying an expression level of a target gene, comprising:
1) synthesizing cDNA from RNA of a subject;
2) performing real-time PCR to amplify the target gene using a pair of primers and/or probes, with the cDNA serving as a template and then performing real-time PCR to amplify the candidate endogenous reference gene using the composition; and
2) normalizing the expression level of the target gene to that of the candidate endogenous reference gene.
In accordance with yet another aspect thereof, the present invention provides a method for identifying the amplification of a target gene in genomic DNA, comprising:
1) amplifying the target gene with a pair of primers or probes through real-time PCR, with a genomic DNA of a subject serving as a template and than performing real-time PCR to amplify the candidate endogenous reference gene with the composition; and
2) normalizing the expression level of the target gene to that of the candidate endogenous reference gene.
MODE FOR INVENTION
A better understanding of the present invention may be obtained through the following examples which are set forth to illustrate, but are not to be construed as the limit of the present invention.
Example 1
Gene Expression Dataset Construction
EST (expressed sequence tag) and SAGE (serial analysis of gene expression) human gene expression data were collected from the publicly available CGAP site (The Cancer Genome Project, http://cgap.nci.nih.gov/). Microarray gene expression data were obtained from the GeneExpress Oncology DatasuiteTM of Gene Logic Inc., based on the Affymetrix Human Genome U133 array set.
Out of a total of 8,633 libraries in Hs_LibData.dat (31 Oct. 2005) file, 77 libraries meeting the requirements: 1) non-normalized and 2)>10,000 sequences, were included in the EST dataset constructed from the CGAP site. EST frequency in each library was obtained from Hs_ExprData.dat (31 Oct. 2005) file. 29 different tissues, including normal and tumor samples, and 26,117 UniGene clusters were included in these libraries.
SAGE short data for all 280 libraries (Hs_short.frequencies.gz, 5 Dec. 2006), representing 38,290 UniGene clusters, and SAGE long data (Hs_long.frequencies.gz, 5 Dec. 2006) for 46 libraries, representing 21,868 UniGene clusters, were used in creating the dataset for SAGE short (ShortSAGE) and long (LongSAGE), respectively. Also, SAGE tags were mapped to UniGene clusters using the files Hs_short.best_gene.gz (5 Dec. 2006) and Hs_long.best_gene.gz (5 Dec. 2006). ShortSAGE and LongSAGE contained information on SAGE expression in 28 and 9 different tissues, including normal and tumor samples, respectively.
Affymetrix GeneChips gene expression data from 567 different samples representing 13 different tissues including the brain, the breast, the colon, the esophagus, the kidney, the liver, the lung, the lymph node, the ovary, the pancreas, the prostate, the rectum and the stomach were also analyzed (Table 11). Affymetrix (CA) HG-U133 and 44,760 different probe sets (total 44,928 probe sets) were included in the microarray dataset.
Example 2
Selection of Candidate ERG
Using the datasets constructed in Example 1, expression level was calculated for UniGene clusters so as to search for housekeeping genes which are constitutively expressed in most human tissues.
Gene expression levels of EST dataset for each gene were calculated as the number of ESTs of a gene in a given library, divided by the total number of ESTs in all genes in a given library and then multiplied by 1,000,000, as expressed by Mathematical Formula 1.
Likewise, Gene expression levels of SAGE dataset for each gene were calculated as the number of tags (sum of tag frequency) of a gene in a given library, divided by the total number of tags and then multiplied by 1,000,000, as expressed by Mathematical Formula 2.



  
    
      
    
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        Mathematical
        ⁢
        
          
        
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      ⁢
      
        
      
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          Total
          ⁢
          
            
          
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            .
            
              
            
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Expression levels in Microarray dataset were represented by the signal intensity calculated for each transcript by the analysis algorithm of Affymetrix Microarray Suite 5.0. Mean gene expression was defined as the average of gene expression level of a given gene in all libraries.
HKGs for use in identifying endogenous reference genes, which are expressed in most human tissues, were investigated using EST and SAGE datasets. In order to examine whether a given gene might be an HKG which is constitutively expressed across a wide range of tissues, the proportion of the tissues not expressing the given gene to the total tissues of the EST and SAGE datasets was calculated. If gene expression frequency is found in any one library of multiple libraries corresponding to one tissue, that gene was considered to be expressed in that tissue. For this, the 0's proportion, which is defined as the ratio of the number of the tissues in which a given gene was not expressed to the total number of tissues, was introduced. In the 0's proportion, “0” indicates that the gene is expressed in all tissues, and conversely, “1” means that the gene is not expressed in any tissue.




  
    
      
        
      
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          〈
          
            Mathematical
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In a study of 101 samples obtained from 47 different human tissues and cell lines, cutoff values for the 0's proportion were determined in each of EST and SAGE datasets so as to include most of the 575 housekeeping genes identified from previous microarray data using the Affymetrix U95A chip (CA), containing 2,600 probes (Eisenberg E and Levanon E Y, Trends Genet, 19(7), 362-365, 2003). Genes with 0's proportion <0.4 for EST (EST, 4,027 UniGene clusters), 0.1 for ShortSAGE (4,758 UniGene clusters) and 0.3 for LongSAGE (4,569 UniGene clusters) were sorted. 2,087 genes common to the three datasets were selected
Out of the 575 genes obtained by U95A, 451(78.43%) in EST, 432(75.13%) in ShortSAGE, and 446(77.57%) in LongSAGE were included in the selected housekeeping genes, respectively. A majority of the 575 HKGs was found to have low 0's proportion in the constructed datasets, EST, ShortSAGE and LongSAGE even though some genes showed the 0's proportion greater than 0.5 unexpectedly. Traditional reference genes like RPLP0, ACTB, PPIA, GAPDH, PGK1, B2M and were TFRC also found in the 2,087 genes.
The mean gene expression value and CV (%) of the housekeeping genes selected from the EST and SAGE datasets were calculated in the microarray dataset (Affymetrix HG-U133, CA). The microarray expression data of 5,238 different probe sets (gene expression data for 5,317 fragments, 1,990 UniGene clusters) corresponding to the selected HKGs were obtained.
UniGene clusters were used to allow respective gene probes to correspond thereto in the datasets. On the chip set HG-U133 were found cases where multiple probe sets, which show various expression intensities, correspond to one gene or UniGene cluster. In such cases, one probe set for one UniGene cluster, showing the lowest CV among several probe sets, was selected.
The 2,087 HKGs obtained above were categorized as “candidate ERGs” or “candidate reference genes” in accordance with the present invention.
Experimental Example 1
Analysis of Candidate ERG
<1-1> Functional Classification of Candidate ERG
Using FunCat (Functional Classification Catalogue, Version 2.0, Ruepp, A., et al. Nucleic Acids Res, 32, 5539-45, 2004), the 2,087 genes obtained above were classified.
Out of the 2,087 candidate ERGs, 1,689 UniGene clusters were associated with GO terms allocated to MIPS (Munich Information Center for Protein Sequences) FunCat (Functional Catalogue). Among the 1,689 UniGene clusters, 1,318 UniGene clusters were functionally classified to be associated with GO terms corresponding to biological processes. These 1,318 genes were identified to be involved in various basic cellular functions. While a high proportion of the previously reported traditional HKGs encode metabolism and ribosome proteins (Eisenberg E & Levanon EY, Trends Genet 19:362-5, 2003; Hsiao L L et al., Physiol Genomics 7:97-104, 2001), genes encoding proteins involved in protein fate (23%, 308/1318) and cellular transport (21%, 273/1318) are found in large amounts in the candidate ERGs (FIG. 2).
<1-2> Analysis of Candidate ERGs for CpG Island
Sequences upstream of the annotated transcription start site of the ERGs according to the present invention were obtained from the UCSC site (//hgdownload.cse.ucsc.edu/goldenPath/hg18/bigZips/). CpG islands located 1,000, 2,000 and 5,000 bp upstream of the transcription start points on the basis of a DNA sequence longer than 500 bp, and having a G+C content of 55% and a CpG observed/expected ratio of 0.65 (Takai D & Jones P A Proc Natl Acad Sci USA, 99, 3740-5, 2002), were searched for using CpGIE software (Wang, Y & Leung, F C Bioinformatics, 20, 1170-7, 2004).
The Z-test (R program, //www.R-project.org) was applied to assess whether there was a statistical significance of differences in the frequency of genes with CpG island between the candidate ERGs and non-candidate ERGs. P<0.05 was considered to be significant.
In line with the previous reports (Larsen, F., et al., Genomics, 13, 1095-107. 1992; Ponger, L., et al., Genome Res, 11, 1854-60. 42, 2001), most candidate ERGs were found to show high frequencies of CpG islands in upstream sequences (1000 bp; 70%, 2000 bp; 73%, 5000 bp; 76%). In contrast, CpG islands were found at low frequencies in the upstream sequences of non-candidate ERGs (p<0.001, Table 1).







TABLE 1







Comparison of the Proportion of Genes with CpG Islands


in Upstream Sequences of the transcription start site in


Candidate ERG and Non-Candidate ERG












Non-Candidate ERG




Candidate ERG
(No. = 14848)












(No. = 2002)

Ratios of













Upstream
No. of
Ratios of Genes
No. of
Genes with
p-


Bp
Genes
with CpG Islands
Genes
CpG Islands
values





5000
1516
76%
8036
54%
<0.001


2000
1456
73%
7410
50%
<0.001


1000
1410
70%
7048
47%
<0.001









Experimental Example 2
Correlation Analysis
Correlation analysis was performed using a correlation coefficient, which indicates linear association between two groups, with a significance level of p<0.05. All calculations and scatter plots were produced with the statistical analysis program R-Package (//www.r-project.org).
First, Pearson and Spearman's rank correlation analysis were performed to compare the candidate ERGs selected from the four datasets in terms of gene expression and CV. FIG. 3 is a scatter plot of gene expression for the four datasets of the candidate ERGs. It was observed that there was a significant correlation of expression values between all four datasets. ShortSAGE versus LongSAGE showed the highest Spearman correlation coefficient of 0.853 (p<0.0001) and the lowest Spearman correlation of 0.339 between EST and Microarray (p<0.0001).
Next, the coefficient of variation (CV, %) was computed to investigate the consistency of the expression level of the candidate ERGs across various libraries in each dataset. Pearson and Spearman's rank correlation analyses were performed on the CV thus obtained, indicating that the CV was less similar between datasets (Spearman correlation coefficient <0.5) than was the gene expression level although a significant correlation was still found (p≦0.001) (FIG. 4).
These results may be attributed to the difference in the kind and number of samples between datasets because expression levels may vary depending on the kind and number of the samples.
Experimental Example 3
Comparison between Candidate ERG and Non-Candidate ERG
A t-test was conducted to examine whether there was a significant difference in mean gene expression between candidate ERG and non-candidate ERG. FIG. 5 shows the distribution of the gene expressions of candidate ERG and non-candidate ERG for each dataset. As was expected, the mean gene expression level of the candidate ERGs was significantly higher than that of non-candidate ERGs in all four datasets (p<0.0001). These results are in line with previous reports (Eisenberg E and Levanon E Y, Trends Genet, 19(7), 362-365, 2003).
Gene expression levels were found to range from 73.83 to 9324.87 in EST, from 28.58 to 4086.25 in ShortSAGE, from 17.47 to 4621.60 in LongSAGE, and from 1.47 to 18598.26 in HG-U133 microarray. A significant number of genes encoding ribosomal proteins showed the highest expression levels in all four datasets. The most abundant transcript was found to come from EEF1A1 in EST and LongSAGE, from DGK1 in ShortSAGE, and from RPL10A in HG-U133 microarray (Table 2)







TABLE 2





A list of 2087 candidate endogenous reference genes


















UniGene


EST












cluster
Symbol
Gene Names
Mean
CV
0's P





  120
PRDX6
Peroxiredoxin 6
458.61
113.71
0.034


  142
SULT1A1
Sulfotransferase family, cytosolic, 1A, phenol-preferring, member
1248.16
105.30
0.241


  202
TSPO
translocator protein
198.55
80.83
0.207


  429
ATP5G3
ATP synthase, H+ transporting, mitochondrial F0 complex, subuni
211.73
76.87
0.103




c (subunit 9) isoform 3





  695
CSTB
Cystatin B (stefin B)
138.20
109.45
0.345


  808
HNRPF
Heterogeneous nuclear ribonucleoprotein F
340.14
74.87
0.034


  861
MAPK3
Mitogen-activated protein kinase 3
145.68
106.68
0.241


 1063
SNRPC
Small nuclear ribonucleoprotein polypepticte C
171.26
77.26
0.276


 1103
TGFB1
Transforming growth factor, beta 1 (Camurati-Engelmann disease)
197.32
110.45
0.345


 2430
VPS72
Vacuolar protein sorting 72 homolog (S. cerevisiae)
117.28
76.90
0.241


 2533
ALDH9A1
Aldehyde dehydrogenase 9 family, member A1
119.81
68.68
0.207


 2795
LDHA
Lactate dehydrogenase A
723.58
109.92
0.034


 2853
PCBP1
Poly(rC) binding protein 1
203.55
81.02
0.103


 3100
KARS
Lysyl-tRNA synthetase
242.90
76.66
0.138


 3254
MRPL23
Mitochondrial ribosomal protein L23
105.59
58.85
0.379


 3353
G3BP1
GTPase activating protein (SH3 domain) binding protein 1
221.63
105.29
0.138


 3416
ADFP
Adipose differentiation-related protein
250.88
167.90
0.241


 3439
STOML2
Stomatin (EPB72)-like 2
303.44
78.37
0.069


 3530
FUSIP1
FUS interacting protein (serine/arginine-rich) 1
188.96
77.05
0.138


 3989
PLXNB2
Plexin B2
365.44
108.04
0.138


 4055
KLF6
Kruppel-like factor 6
258.77
121.39
0.276


 4742
GPAA1
GPAA1P anchor attachment protein 1 homolog (yeast)
334.17
107.33
0.207


 4747
DKC1
Dyskeratosis congenita 1, dyskerin
232.08
109.39
0.138


 4766
FAM32A
Family with sequence similarity 32, member A
182.68
72.56
0.138


 4859
CCNL1
Cyclin L1
117.20
67.94
0.379


 4997
RBM23
RHA binding motif protein 23
151.36
66.00
0.345


 4998
TMOD3
Tropomodulin 3 (ubiquitous)
117.77
105.21
0.345


 5062
TSPAN3
Tetraspanin 3
230.30
90.95
0.069


 5086
RBM42
RNA binding motif protein 42
232.32
80.47
0.172


 5120
DYNLL1
Dynein, light chain, LC8-type 1
202.21
103.08
0.103


 5158
ILK
Integrin-linked kinase-2
154.41
64.84
0.138


 5245
PIH1D1
PIH1 domain containing 1
300.56
124.75
0.207


 5258
MAGED1
Melanoma antigen family D, 1
605.46
103.33
0.138


 5268
ZDHHC4
Zinc finger, DHHC-type containing 4
105.02
62.27
0.345


 5298
ADIPOR1
Adiponectin receptor 1
175.47
95.76
0.138


 5308
UBA52
Ubiquitin A-52 residue ribosomal protein fusion product 1
482.46
229.44
0.103


 5324
C2orf25
Chromosome 2 open reading frame 25
665.12
222.84
0.138


 5345
RNPEPL1
Arginyl aminopeptidase (aminopeptidase B)-like 1
174.04
85.31
0.310


 5662
GNB2L1
Guanine nucleotide binding protein (G protein), beta polypeptide 2
2888.02
78.73
0.000




like 1





 5710
CREG1
Cellular repressor of E1A-stimulated genes 1
186.09
125.07
0.241


 5719
NCAPD2
Non-SMC condensin I complex, subunit D2
285.44
132.20
0.241


 5912
FBXO7
F-box protein 7
203.36
91.84
0.207


 5947
RAB8A
RAB8A, member RAS oncogene family
195.76
70.42
0.138


 6396
JTB
Jumping translocation breakpoint
264.77
96.40
0.172


 6454
GIPC1
GIPC PDZ domain containing family, member 1
283.16
100.25
0.069


 6459
GPR172A
G protein-coupled receptor 172A
180.95
83.98
0.276


 6551
ATP6AP1
ATPase, H+ transporting, lysosomal accessory protein 1
238.13
103.93
0.207


 6891
SFRS6
Splicing factor, arginine/serine-rich 6
131.50
89.49
0.241


 7101
ANAPC5
Anaphase promoting complex subunit 5
248.20
68.36
0.103


 7236
NOSIP
Nitric oxide synthase interacting protein
160.80
86.71
0.310


 7476
ATP6V0B
ATPase, H+ transporting, lysosomal 21 kDa, V0 subunit c′′
179.43
84.77
0.241


 7527
REXO2
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
137.24
85.72
0.379


 7744
NDUFV1
NADH dehydrogenase (ubiquinone) flavoprotein 1, 51 kDa
373.45
70.69
0.069


 7753
CALU
Calumenin
251.14
83.95
0.069


 7768
FIBP
Fibroblast growth factor (acidic) intracellular binding protein
149.44
71.07
0.138


 7862
PNRC2
Proline-rich nuclear receptor coactivator 2
165.82
66.37
0.241


 7910
RYBP
RING1 and YY1 binding protein
148.78
147.82
0.310


 7917
HIGD1A
HIG1 domain family, member 1A
1039.59
201.55
0.103


 8102
RPS20
Ribosomal protein S20
808.74
200.51
0.000


 8372
UQCR
Ubiquinol-cytochrome c reductase, 6.4 kDa subunit
171.69
131.04
0.172


 8737
WDR6
WD repeat domain 6
214.98
113.65
0.172


 8752
TMEM4
Transmembrane protein 4
133.39
83.23
0.345


 8765
DDX42
DEAD (Asp-Glu-Ala-Asp) box polypeptide 42
139.51
72.23
0.310


 8859
CANT1
Calcium activated nucleotidase 1
195.72
80.27
0.310


 8867
CYR61
Cysteine-rich, angiogenic inducer, 61
267.57
79.91
0.379


 9003
C16orf58
Chromosome 16 open reading frame 58
148.64
68.89
0.207


 9015
LOC57255
Hypothetical locus LOC572558
130.09
98.43
0.276


 9043
NGDN
Neuroguidin, EIF4E binding protein
117.81
54.04
0.379


 9234
TMEM147
Transmembrane protein 147
129.58
83.82
0.207


 9235
NME4
Protein expressed in non-metastatic cells 4
148.59
103.05
0.379


 9527
C2orf28
Chromosome 2 open reading frame 28
184.04
88.83
0.207


 9534
SEC11A
SEC11 homolog A (S. cerevisiae)
146.99
82.65
0.069


 9573
ABCF1
ATP-binding cassette, sub-family F (GCN20), member 1
173.73
124.13
0.276


 9589
UBQLN1
Ubiquilin 1
111.34
60.19
0.310


 9788
NDFIP1
Nedd4 family interacting protein 1
167.04
73.62
0.172


 9825
FAM96B
Family with sequence similarity 96, member B
139.95
94.16
0.345


 9857
DCXR
Dicarbonyl/L-xylulose reductase
170.77
74.16
0.379


 10326
COPE
Coatomer protein complex, subunit epsilon
383.31
95.38
0.103


 10842
RAN
RAN, member RAS oncogene family
825.56
82.38
0.000


 10848
BMS1
BMS1 homolog, ribosome assembly protein (yeast)
121.69
60.27
0.345


 11125
SPCS1
Signal peptidase complex subunit 1 homolog (S. cerevisiae)
151.97
92.91
0.276


 11184
UBE2R2
Ubiquitin-conjugating enzyme E2R 2
379.09
474.01
0.172


 11223
IDH1
Isocitrate dehydrogenase 1 (NADP+), soluble
199.04
77.27
0.103


 11355
TMPO
Thymopoietin
213.98
130.12
0.172


 11463
CMPK
Cytidylate kinase
180.54
86.53
0.172


 12013
ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
179.59
72.05
0.241


 12084
TUFM
Tu translation elongation factor, mitochondrial
518.02
95.08
0.207


 12102
SNX3
Sorting nexin 3
280.04
91.18
0.207


 12107
CHMP2A
Chromatin modifying protein 2A
108.77
44.44
0.207


 12109
CIAO1
Cytosolic iron-sulfur protein assembly 1 homolog (S. cerevisiae)
127.53
69.27
0.207


 12144
KIAA1033
KIAA1033
109.38
59.10
0.345


 12152
SRPRB
Signal recognition particle receptor, B subunit
197.29
199.04
0.310


 12272
BECN1
Beclin 1 (coiled-coil, myosin-like BCL2 interacting protein)
135.99
56.22
0.310


 12341
ADAR
Adenosine deaminase, RNA-specific
272.66
83.29
0.103


 12457
NUP133
Nucleoporin 133 kDa
134.39
100.25
0.310


 12865
NSFL1C
NSFL1 (p97) cofactor (p47)
137.86
79.36
0.276


 13662
TMEM109
Transmembrane protein 109
180.15
110.32
0.276


 14317
NOLA3
Nucleolar protein family A, member 3 (H/ACA small nucleolar
205.32
119.91
0.310




RNPs)





 14333
ATPBD1B
ATP binding domain 1 family, member B
159.24
82.57
0.379


 14745
CCNY
Cyclin Y
133.37
75.66
0.276


 14839
POLR2G
Polymerase (RNA) II (DNA directed) polypeptide G
141.30
66.30
0.207


 14846
SLC7A1
Solute carrier family 7 (cationic amino acid transporter, y+ system
139.07
71.59
0.310




member 1





 14894
TGOLN2
Trans-golgi network protein 2
157.54
69.37
0.241


 15277
C16orf33
Chromosome 16 open reading frame 33
120.09
75.30
0.310


 15591
COPS6
COP9 constitutive photomorphogenic homolog subunit 6
217.83
90.78
0.172




(Arabidopsis)





 15738
RAB7A
RAB7A, member RAS oncogene family
400.18
95.67
0.069


 16059
CCDC56
Coiled-coil domain containing 56
143.39
86.29
0.345


 16130
UBE2O
Ubiquitin-conjugating enzyme E2O
157.52
114.59
0.241


 16349
ASCIZ
ATM/ATR-Substrate Chk2-Interacting Zn2+-finger protein
122.72
69.67
0.310


 17118
C1orf149
Chromosome 1 open reading frame 149
139.92
85.35
0.310


 17250
COQ5
Coenzyme Q5 homolog, methyltransferase (S. cerevisiae)
91.88
50.52
0.345


 17680
FUCA2
Fucosidase, alpha-L-2, plasma
157.91
93.28
0.276


 17731
CCDC14
Coiled-coil domain containing 14
84.79
48.78
0.379


 17883
PPM1G
Protein phosphatase 1G (formerly 2C), magnesium-dependent,
381.13
94.17
0.103




gamma isoform





 18069
LGMN
Legumain
189.38
150.90
0.310


 18128
C20orf44
Chromosome 20 open reading frame 44
120.34
63.49
0.276


 18349
MRPL15
Mitochondrial ribosomal protein L15
126.02
62.29
0.310


 19673
MAF1
MAF1 homolog (S. cerevisiae)
208.66
72.97
0.069


 20013
SYF2
SYF2 homolog, RNA splicing factor (S. cerevisiae)
109.39
47.58
0.310


 20107
KLC1
Kinesin light chain 1
158.65
81.31
0.241


 20157
CDK5RAP3
CDK5 regulatory subunit associated protein 3
186.17
71.88
0.276


 20521
PRMT1
Protein arginine methyltransferase 1
270.96
72.70
0.103


 20529
FAM79A
Family with sequence similarity 79, member A
101.33
68.50
0.379


 20573
IGF1R
Insulin-like growth factor 1 receptor
133.12
72.84
0.379


 20716
TIMM17A
Translocase of inner mitochondrial membrane 17 homolog A
378.20
138.09
0.241




(yeast)





 22393
DENR
Density-regulated protein
147.59
60.97
0.138


 22543
UBE3A
Ubiquitin protein ligase E3A (human papilloma virus E6-associated
180.41
98.42
0.276




protein, Angelman syndrome)





 22546
CYBASC3
Cytochrome b, ascorbate dependent 3
271.22
114.11
0.276


 22616
KIAA0664
KIAA0664 protein
126.85
69.83
0.276


 23033
UBE2Q2
Ubiquitin-conjugating enzyme E2Q (putative) 2
127.34
80.73
0.379


 23111
FARSA
Phenylalanyl-tRNA synthetase, alpha subunit
239.95
79.63
0.241


 23978
SAFB
Scaffold attachment factor B
195.91
87.35
0.207


 24301
POLR2E
Polymerase (RNA) II (DNA directed) polypeptide E, 25 kDa
345.43
77.04
0.207


 24379
TRAPPC1
Trafficking protein particle complex 1
155.30
123.38
0.172


 24601
FBLN1
Fibulin 1
492.05
242.68
0.345


 24950
RGS5
Regulator of G-protein signalling 5
561.58
225.25
0.345


 25155
NET1
Neuroepithelial cell transforming gene 1
114.28
95.82
0.207


 25450
SLC29A1
Solute carrier family 29 (nucleoside transporters), member 1
201.64
68.32
0.379


 25723
FAM89B
Family with sequence similarity 89, member B
140.19
148.04
0.345


 26010
PFKP
Phosphofructokinase, platelet
268.83
113.15
0.103


 26023
FOXJ3
Forkhead box J3
73.83
44.60
0.379


 26136
PIGY
Phosphatidylinositol glycan anchor biosynthesis, class Y
150.82
96.10
0.345


 26232
MAN2C1
Mannosidase, alpha, class 2C, member 1
117.43
87.14
0.379


 26403
GSTZ1
Glutathione transferase zeta 1 (maleylacetoacetate isomerase)
139.46
92.67
0.345


 26518
TSPAN4
Tetraspanin 4
164.19
75.89
0.310


 27222
NOLA2
Nucleolar protein family A, member 2 (H/ACA small nucleolar
172.83
107.54
0.276




RNPs)





 28491
SAT1
Spermidine/spermine N1-acetyltransferase 1
578.08
192.92
0.276


 28914
APRT
Adenine phosphoribosyltransferase
160.48
119.31
0.345


 29203
GBL
G protein beta subunit-like
172.86
96.17
0.310


 29665
CLSTN1
Calsyntenin 1
223.34
109.23
0.103


 30011
TMEM93
Transmembrane protein 93
122.56
80.02
0.379


 30026
SSU72
SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)
122.96
77.31
0.138


 30345
TRAP1
TNF receptor-associated protein 1
433.73
106.66
0.103


 30954
PMVK
Phosphomevalonate kinase
168.78
141.42
0.379


 31053
TBCB
Tubulin folding cofactor B
267.45
128.93
0.276


 31334
PRPF6
PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)
278.00
95.93
0.103


 31387
C3orf60
Chromosome 3 open reading frame 60
194.85
96.83
0.276


 34045
CDCA4
Cell division cycle associated 4
142.01
95.48
0.379


 34576
TAX1BP1
Tax1 (human T-cell leukemia virus type I) binding protein 1
166.29
86.39
0.138


 34906
BLOC1S2
Biogenesis of lysosome-related organelles complex-1, subunit 2
110.24
106.36
0.345


 35052
TEGT
Testis enhanced gene transcript (BAX inhibitor 1)
601.46
76.56
0.000


 35828
MARK3
MAP/microtubule affinity-regulating kinase 3
181.74
68.97
0.207


 36587
PPP1R7
Protein phosphatase 1, regulatory subunit 7
147.34
89.65
0.207


 36927
HSPH1
Heat shock 105 kDa/110 kDa protein 1
142.61
62.36
0.241


 37616
STRA13
Stimulated by retinoic acid 13 homolog (mouse)
132.28
87.28
0.310


 37916
DPP7
Dipeptidylpeptidase 7
189.05
126.98
0.207


 42806
SDF4
Stromal cell derived factor 4
395.61
110.02
0.138


 43297
MTPN
Myotrophin
224.31
82.09
0.172


 47062
POLR2I
Polymerase (RNA) II (DNA directed) polypeptide I, 14.5 kDa
136.77
76.60
0.310


 50098
NDUFA4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9 kDa
444.09
142.87
0.310


 50308
HIP2
Huntingtin interacting protein 2
145.77
68.04
0.207


 50425
PTGES3
Prostaglandin E synthase 3 (cytosolic)
411.83
77.96
0.103


 53066
HSPBP1
Hsp70-interacting protein
202.07
92.49
0.138


 54277
FAM50A
Family with sequence similarity 50, member A
145.83
129.34
0.345


 54457
CD81
CD81 antigen (target of antiproliferative antibody 1)
303.19
99.16
0.069


 54642
MAT2B
Methionine adenosyltransferase II, beta
133.55
71.29
0.207


 54649
RY1
Putative nucleic acid binding protein RY-1
203.85
97.67
0.241


 55682
EIF3S7
Eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67 kDa
455.77
153.84
0.034


 55847
MRPL51
Mitochondrial ribosomal protein L51
122.64
99.22
0.241


 58488
CTNNAL1
Catenin (cadherin-associated protein), alpha-like 1
126.66
70.42
0.379


 58992
SMC4
Structural maintenance of chromosomes 4
228.66
99.66
0.207


 59486
HSDL2
Hydroxysteroid dehydrogenase like 2
129.48
73.68
0.345


 61812
PTPN12
Protein tyrosine phosphatase, non-receptor type 12
108.62
74.97
0.345


 65234
DDX27
DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
199.19
91.01
0.241


 65238
RNF40
Ring finger protein 40
193.26
81.38
0.172


 66048
MAP1S
Microtubule-associated protein 1S
131.74
79.04
0.276


 66915
C22orf16
Chromosome 22 open reading frame 16
135.11
102.77
0.379


 68714
SFRS1
Splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate
249.07
79.18
0.103




splicing factor)





 69293
HEXB
Hexosaminidase B (beta polypeptide)
198.57
153.59
0.276


 69554
RNF126
Ring finger protein 126
161.03
83.35
0.241


 69855
UNR
Cold shock domain containing E1, RNA-binding
657.29
110.51
0.103


 71465
SQLE
Squalene epoxidase
105.27
62.62
0.276


 71787
MRPS7
Mitochondrial ribosomal protein S7
159.90
59.92
0.310


 73527
CSNK2B
Casein kinase 2, beta polypeptide
202.65
73.01
0.207


 73722
APEX1
APEX nuclease (multifunctional DNA repair enzyme) 1
339.50
85.30
0.103


 73799
GNAI3
Guanine nucleotide binding protein (G protein), alpha inhibiting
150.46
62.95
0.207




activity polypeptide 3





 73965
SFRS2
Hypothetical protein ET
280.26
73.78
0.000


 74047
ETFB
Electron-transfer-flavoprotein, beta polypeptide
168.06
80.53
0.138


 74050
FVT1
Follicular lymphoma variant translocation 1
98.29
70.32
0.379


 74137
TMED10
Transmembrane emp24-like trafficking protein 10 (yeast)
237.09
91.81
0.138


 74375
DVL1
Dishevelled, dsh homolog 1 (Drosophila)
133.54
77.04
0.276


 74405
YWHAQ
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
413.13
88.00
0.034




activation protein, theta polypeptide





 74471
GJA1
Gap junction protein, alpha 1, 43 kDa (connexin 43)
183.35
62.77
0.379


 74563
OAZ2
Ornithine decarboxylase antizyme 2
193.33
73.23
0.103


 74564
SSR2
Signal sequence receptor, beta (translocon-associated protein
312.91
86.38
0.034




beta)





 74576
GDI1
GDP dissociation inhibitor 1
230.50
117.59
0.138


 75056
TIMM13
Translocase of inner mitochondrial membrane 13 homolog (yeast)
225.25
76.11
0.345


 75061
MARCKSL
MARCKS-like 1
449.23
89.23
0.103


 75066
TSN
Translin
128.46
75.98
0.345


 75087
FASTK
Fas-activated serine/threonine kinase
179.08
68.42
0.345


 75117
ILF2
Interleukin enhancer binding factor 2, 45 kDa
349.26
76.78
0.034


 75133
TFAM
Transcription factor A, mitochondrial
111.21
68.59
0.310


 75139
ARFIP2
ADP-ribosylation factor interacting protein 2 (arfaptin 2)
178.80
116.43
0.345


 75189
DAP
Death-associated protein
217.73
94.24
0.103


 75227
NDUFA9
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39
290.29
122.15
0.138


 75243
BRD2
Bromodomain containing 2
301.76
102.55
0.069


 75249
ARL6IP1
ADP-ribosylation factor-like 6 interacting protein 1
269.13
69.42
0.172


 75254
IRF3
Interferon regulatory factor 3
131.45
93.03
0.345


 75318
TUBA4A
Tubulin, alpha 4a
346.93
95.88
0.276


 75348
PSME1
Proteasome (prosome, macropain) activator subunit 1 (PA28
196.67
85.95
0.138




alpha)





 75438
QDPR
Quinoid dihydropteridine reductase
239.93
101.27
0.345


 75527
ADSL
Adenylosuccinate lyase
187.36
79.69
0.000


 75724
COPB2
Coatomer protein complex, subunit beta 2 (beta prime)
169.19
70.94
0.172


 75798
C20orf111
Chromosome 20 open reading frame 111
138.12
60.97
0.379


 75841
ERP29
Endoplasmic reticulum protein 29
170.38
80.11
0.276


 75890
MBTPS1
Membrane-bound transcription factor peptidase, site 1
143.96
76.79
0.241


 75914
TMED2
Transmembrane emp24 domain trafficking protein 2
257.34
78.55
0.103


 76111
DAG1
Dystroglycan 1 (dystrophin-associated glycoprotein 1)
185.89
66.32
0.310


 76394
ECHS1
Enoyl Coenzyme A hydratase, short chain, 1, mitochondrial
296.18
99.29
0.207


 76480
UBL4A
Ubiquitin-like 4A
177.47
73.71
0.379


 76662
ZDHHC16
Zinc finger, DHHC-type containing 16
138.92
90.05
0.276


 76686
GPX1
Glutathione peroxidase 1
154.93
84.27
0.276


 76847
GANAB
Glucosidase, alpha; neutral AB
371.62
103.22
0.138


 77060
PSMB6
Proteasome (prosome, macropain) subunit, beta type, 6
258.61
103.69
0.172


 77269
GNAI2
Guanine nucleotide binding protein (G protein), alpha inhibiting
454.86
93.08
0.103




activity polypeptide 2





 77313
CDK10
Cyclin-dependent kinase (CDC2-like) 10
98.89
72.87
0.345


 77422
PLP2
Proteolipid protein 2 (colonic epithelium-enriched)
189.36
121.71
0.310


 77558
HMGN3
High mobility group nucleosomal binding domain 3
161.44
94.74
0.207


 77578
USP9X
Ubiquitin specific peptidase 9, X-linked (fat facets-like, Drosophila)
143.39
67.26
0.310


 77793
CSK
C-src tyrosine kinase
222.19
95.17
0.310


 77897
SF3A3
Splicing factor 3a, subunit 3, 60 kDa
169.65
127.16
0.276


 77961
HLA-B
Major histocompatibility complex, class I, B
851.44
157.10
0.103


 77978

Hypothetical protein DKFZp761I2123
115.47
65.78
0.345


 78466
PSMD8
Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
274.96
128.74
0.241


 78601
UROD
Uroporphyrinogen decarboxylase
187.65
84.63
0.103


 78771
PGK1
Phosphoglycerate kinase 1
681.19
86.72
0.034


 78880
ILVBL
IlvB (bacterial acetolactate synthase)-like
185.37
153.08
0.379


 78888
DBI
Diazepam binding inhibitor (GABA receptor modulator, acyl-
220.96
127.35
0.241




Coenzyme A binding protein)





 78989
ADH5
Alcohol dehydrogenase 5 (class III), chi polypeptide
179.39
72.64
0.034


 79064
DHPS
Deoxyhypusine synthase
164.95
100.52
0.241


 79081
PPP1CC
Protein phosphatase 1, catalytic subunit, gamma isoform
318.25
84.70
0.103


 79088
RCN2
Reticulocalbin 2, EF-hand calcium binding domain
150.90
75.39
0.207


 79101
CCNG1
Cyclin G1
240.04
67.65
0.069


 79110
NCL
Nucleolin
293.04
63.35
0.034


 79322
QARS
Glutaminyl-tRNA synthetase
402.46
67.92
0.138


 79335
SMARCD1
SWI/SNF related, matrix associated, actin dependent regulator of
146.36
68.95
0.241




chromatin, subfamily d, member 1





 79387
PSMC5
Proteasome (prosome, macropain) 26S subunit, ATPase, 5
243.74
74.96
0.138


 79402
POLR2C
Polymerase (RNA) II (DNA directed) polypeptide C, 33 kDa
146.42
65.99
0.241


 79411
RPA2
Replication protein A2, 32 kDa
179.33
111.72
0.345


 79625
C20orf149
Chromosome 20 open reading frame 149
361.43
94.87
0.310


 80545
RPL37
Ribosomal protein L37
755.77
355.66
0.103


 80919
SYPL1
Synaptophysin-like 1
215.72
101.08
0.207


 80986
ATP5G1
ATP synthase, H+ transporting, mitochondrial F0 complex, subuni
209.65
91.99
0.276




c (subunit 9), isoform 1





 81328
NFKBIA
Nuclear factor of kappa light polypeptide gene enhancer in B-cells
186.76
120.33
0.345




inhibitor, alpha





 81424
SUMO1
SMT3 suppressor of mif two 3 homolog 1 (yeast)
313.72
89.00
0.034


 81848
RAD21
RAD21 homolog (S. pombe)
368.76
164.73
0.103


 81964
SEC24C
SEC24 related gene family, member C (S. cerevisiae)
186.43
96.07
0.241


 82201
CSNK2A2
Casein kinase 2, alpha prime polypeptide
123.76
72.38
0.310


 82327
GSS
Glutathione synthetase
184.39
77.08
0.138


 82719
YIPF6
Yip1 domain family, member 6
123.85
72.31
0.379


 82793
PSMB3
Proteasome (prosome, macropain) subunit, beta type, 3
158.41
64.83
0.138


 82887
PPP1R11
Protein phosphatase 1, regulatory (inhibitor) subunit 11
190.42
75.63
0.241


 82890
DAD1
Defender against cell death 1
202.51
132.00
0.310


 82916
CCT6A
Chaperonin containing TCP1, subunit 6A (zeta 1)
407.59
75.69
0.034


 82927
AMPD2
Adenosine monophosphate deaminase 2 (isoform L)
148.16
149.07
0.345


 83190
FASN
Fatty acid synthase
562.35
101.57
0.241


 83347
AAMP
Angio-associated, migratory cell protein
224.46
80.95
0.138


 83383
PRDX4
Peroxiredoxin 4
152.24
74.89
0.379


 83734
STX4
Syntaxin 4
117.13
61.41
0.276


 83753
SNRPB
Small nuclear ribonucleoprotein polypeptides B and B1
874.09
87.85
0.138


 83765
DHFR
Dihydrofolate reductase
111.62
78.02
0.310


 83916
NDUFA5
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13
455.28
149.11
0.207


 84359
GABARAP
GABA(A) receptor-associated protein
190.65
77.34
0.138


 84753
NT5DC2
5′-nucleotidase domain containing 2
158.64
96.33
0.310


 85155
ZFP36L1
Zinc finger protein 36, C3H type-like 1
196.81
98.76
0.207


 85769
DNTTIP2
Deoxynucleotidyltransferase, terminal, interacting protein 2
105.55
51.70
0.379


 85962
CTF8
Chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
170.29
139.62
0.276


 86131
FADD
Fas (TNFRSF6)-associated via death domain
158.82
101.13
0.172


 87752
MSN
Moesin
275.46
95.27
0.103


 89545
PSMB4
Proteasome (prosome, macropain) subunit, beta type, 4
463.81
87.69
0.034


 89643
TKT
Transketolase (Wernicke-Korsakoff syndrome)
588.97
97.80
0.103


 89649
EPHX1
Epoxide hydrolase 1, microsomal (xenobiotic)
238.26
88.30
0.345


 89781
UBTF
Upstream binding transcription factor, RNA polymerase I
121.71
54.79
0.241


 89864
SKIV2L
Superkiller viralicidic activity 2-like (S. cerevisiae)
132.50
66.99
0.379


 90061
PGRMC1
Progesterone receptor membrane component 1
194.16
93.36
0.172


 90093
HSPA4
Heat shock 70 kDa protein 4
149.59
74.25
0.172


 90107
ADRM1
Adhesion regulating molecule 1
246.89
81.18
0.172


 90443
NDUFS8
NADH dehydrogenase (ubiquinone) Fe—S protein 8, 23 kDa
153.66
106.13
0.207




(NADH-coenzyme Q reductase)





 91142
KHSRP
KH-type splicing regulatory protein (FUSE binding protein 2)
237.57
80.25
0.241


 91531
MLLT6
Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog,
163.44
99.71
0.207




Drosophila); translocated to, 6





 93659
PDIA4
Protein disulfide isomerase family A, member 4
221.64
92.23
0.207


 93832
TMCO1
Transmembrane and coiled-coil domains 1
215.75
94.44
0.138


 95577
CDK4
Cyclin-dependent kinase 4
512.67
181.54
0.103


 96530
COX11
COX11 homolog, cytochrome c oxidase assembly protein (yeast)
133.50
61.61
0.241


 96852
EDC3
Enhancer of mRNA decapping 3 homolog (S. cerevisiae)
315.49
327.98
0.345


 96996
HNRPA0
Heterogeneous nuclear ribonucleoprotein A0
203.93
87.67
0.172


 97616
SH3GL1
SH3-domain GRB2-like 1
271.66
106.70
0.069


 97887
RCN1
Reticulocalbin 1, EF-hand calcium binding domain
176.05
78.51
0.207


 98751
FUBP3
Far upstream element (FUSE) binding protein 3
115.91
57.99
0.276


 98791
ACTR1B
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
154.61
74.84
0.276


102696
MCTS1
Malignant T cell amplified sequence 1
182.20
108.79
0.379


102798
PSMA1
Proteasome (prosome, macropain) subunit, alpha type, 1
222.80
73.98
0.069


103561
ARL6IP4
ADP-ribosylation-like factor 6 interacting protein 4
177.34
82.48
0.172


103834
TMEM106C
Transmembrane protein 106C
164.57
88.83
0.138


104839
TIMP2
TIMP metallopeptidase inhibitor 2
266.07
83.65
0.172


105547
NPDC1
Neural proliferation, differentiation and control, 1
184.55
89.27
0.345


106185
RALGDS
Ral guanine nucleotide dissociation stimulator
113.28
56.31
0.379


106876
ATP6V0D1
ATPase, H+ transporting, lysosomal 38 kDa, V0 subunit d isoform 1
157.31
76.54
0.207


106909
ANAPC13
Anaphase promoting complex subunit 13
409.28
124.92
0.310


107003
CCNB1IP1
Cyclin B1 interacting protein 1
198.64
135.06
0.207


107101
C1orf86
Chromosome 1 open reading frame 86
132.02
90.12
0.310


107387
C7orf20
Chromosome 7 open reading frame 20
158.14
146.65
0.379


107393
CLDND1
Claudin domain containing 1
182.62
98.17
0.276


108029
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
217.90
129.37
0.138


108080
CSRP1
Cysteine and glycine-rich protein 1
226.87
81.65
0.172


108371
E2F4
E2F transcription factor 4, p107/p130-binding
124.23
53.45
0.207


108408
APH1A
Anterior pharynx defective 1 homolog A (C. elegans)
214.52
73.54
0.276


108957
RPS27L
Ribosomal protein S27-like
214.43
105.97
0.345


108969
C19orf56
Chromosome 19 open reading frame 56
165.48
98.67
0.207


109051
SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
190.53
95.77
0.207


109052
C14orf2
Chromosome 14 open reading frame 2
254.93
147.67
0.310


109672
ST6GALNAC6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-
113.89
58.27
0.379




acetylgalactosaminide alpha-2,6-sialyltransferase 6





109798
C6orf48
Chromosome 6 open reading frame 48
221.40
98.21
0.207


110695
SF3B5
Splicing factor 3b, subunit 5, 10 kDa
161.11
93.81
0.310


110849
ESRRA
Estrogen-related receptor alpha
243.72
107.89
0.310


111286
MRPS11
Mitochondrial ribosomal protein S11
118.62
52.84
0.207


111577
ITM2C
Integral membrane protein 2C
293.83
115.98
0.138


111801
ARS2
ARS2 protein
213.16
99.08
0.276


112058
SIVA1
SIVA1, apoptosis-inducing factor
161.23
58.99
0.345


112318
TOMM7
Translocase of outer mitochondrial membrane 7 homolog (yeast)
406.79
253.67
0.276


112955
NUDT5
Nudix (nucleoside diphosphate linked moiety X)-type motif 5
197.68
94.29
0.276


114033
SSR1
Signal sequence receptor, alpha (translocon-associated protein
161.00
68.79
0.207




alpha)





114286
CD9
CD9 antigen (p24)
239.20
130.06
0.172


114412
TXNL1
Thioredoxin-like 1
117.31
93.59
0.207


115474
RFC3
Replication factor C (activator 1) 3, 38 kDa
175.70
158.89
0.345


115792
EXOSC7
Exosome component 7
134.25
74.20
0.207


116448
GLS
Glutaminase
192.13
67.06
0.379


117176
PABPN1
Poly(A) binding protein, nuclear 1
124.05
80.27
0.276


117715
ST5
Suppression of tumorigenicity 5
101.33
55.39
0.379


118110
BST2
Bone marrow stromal cell antigen 2
216.68
84.28
0.241


118400
FSCN1
Fascin homolog 1, actin-bundling protein (Strongylocentrotus
684.83
91.57
0.241




purpuratus)





118463
PNPLA2
Patatin-like phospholipase domain containing 2
162.21
88.10
0.345


118638
NME1
Non-metastatic cells 1, protein (NM23A) expressed in
290.12
103.60
0.172


118722
FUT8
Fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
118.38
149.55
0.379


118964
GATAD2A
GATA zinc finger domain containing 2A
124.22
85.19
0.310


118983
GSDMDC1
Gasdermin domain containing 1
184.87
95.75
0.379


119177
ARF3
ADP-ribosylation factor 3
239.68
76.49
0.138


119192
H2AFZ
H2A histone family, member Z
453.31
159.40
0.103


119251
UQCRC1
Ubiquinol-cytochrome c reductase core protein I
442.99
74.48
0.103


119591
AP2S1
Adaptor-related protein complex 2, sigma 1 subunit
177.74
82.21
0.241


119598
RPL3
Ribosomal protein L3
3807.92
79.61
0.000


120323
LOC26010
Viral DNA polymerase-transactivated protein 6
128.35
69.74
0.310


121088
NUP153
Nucleoporin 153 kDa
123.13
79.84
0.310


121549
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
177.98
81.88
0.241




(phosphatidylinositol synthase)





122363
WIPI2
WD repeat domain, phosphoinositide interacting 2
186.76
89.61
0.138


122523
SND1
Staphylococcal nuclease domain containing 1
355.50
74.36
0.034


124126
ARPC1A
Actin related protein 2/3 complex, subunit 1A, 41 kDa
206.46
81.13
0.103


124147
FBXL11
PRO1880 protein
144.07
78.43
0.207


124246
C10orf119
Chromosome 10 open reading frame 119
144.50
66.52
0.172


124366
BBX
Bobby sox homolog (Drosophila)
147.83
66.94
0.345


125113
CCT8
Chaperonin containing TCP1, subunit 8 (theta)
187.53
84.03
0.034


125867
EVL
Enah/Vasp-like
170.08
84.54
0.276


125898
GNAS
GNAS complex locus
669.01
93.40
0.069


126497
AEBP2
AE binding protein 2
102.85
77.77
0.379


126774
DTL
Denticleless homolog (Drosophila)
160.79
71.32
0.379


126938
NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
196.92
84.26
0.069


127092
DHX38
DEAH (Asp-Glu-Ala-His) box polypeptide 38
168.85
103.87
0.379


127249
SNF8
SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)
134.67
80.08
0.310


127386
MAMDC2
MAM domain containing 2
147.47
78.47
0.241


127764
RAB5C
RAB5C, member RAS oncogene family
242.33
112.45
0.276


128065
CTSC
Cathepsin C
238.81
102.05
0.207


128199
SEPT11
Septin 11
159.83
63.97
0.241


128548
WDR1
WD repeat domain 1
267.90
69.81
0.069


129634
CINP
Cyclin-dependent kinase 2-interacting protein
104.53
70.89
0.345


129673
EIF4A1
Eukaryotic translation initiation factor 4A, isoform 1
1492.15
82.19
0.000


130031
TRIO
Triple functional domain (PTPRF interacting)
142.59
75.94
0.310


130098
DDX23
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
188.55
94.45
0.172


130293
CROP
Cisplatin resistance-associated overexpressed protein
152.55
84.06
0.207


130413
TM9SF2
Transmembrane 9 superfamily member 2
210.83
99.09
0.103


131226
BNIP3L
BCL2/adenovirus E1B 19 kDa interacting protein 3-like
192.67
70.38
0.241


132497
PRNPIP
Prion protein interacting protein
168.32
67.74
0.310


132513
HSD17B12
Hydroxysteroid (17-beta) dehydrogenase 12
137.10
95.65
0.207


133892
TPM1
Tropomyosin 1 (alpha)
606.98
169.48
0.207


134074
SLC35E1
Solute carrier family 35, member E1
110.83
70.67
0.345


134688
PSMD13
Proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
304.05
104.85
0.207


135406
CEBPZ
CCAAT/enhancer binding protein zeta
126.72
64.41
0.207


136905
HUWE1
HECT, UBA and WWE domain containing 1
196.13
66.09
0.138


136947
RALY
RNA binding protein, autoantigenic (hnRNP-associated with lethal
339.69
92.28
0.069




yellow homolog (mouse))





137510
NCOR2
Nuclear receptor co-repressor 2
243.82
126.40
0.207


138860
ARHGAP1
Rho GTPase activating protein 1
106.56
50.87
0.310


139896
MAEA
Macrophage erythroblast attacher
203.45
84.45
0.276


140452
M6PRBP1
Mannose-6-phosphate receptor binding protein 1
381.09
119.04
0.138


142442
HP1BP3
Heterochromatin protein 1, binding protein 3
161.28
66.57
0.207


143187
DDX49
DEAD (Asp-Glu-Ala-Asp) box polypeptide 49
144.35
67.10
0.241


143766
ATN1
Atrophin 1
184.56
86.85
0.207


143873
S100A10
S100 calcium binding protein A10 (annexin II ligand, calpactin I,
255.56
111.88
0.172




light polypeptide (p11))





144058
NAT9
N-acetyltransferase 9
99.56
67.02
0.345


144468
CHID1
Chitinase domain containing 1
179.03
105.35
0.241


144835
EEF1G
Eukaryotic translation elongation factor 1 gamma
4056.39
76.55
0.000


144868
VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B
103.57
54.85
0.310




(yeast)





144941
LRRC41
Leucine rich repeat containing 41
152.40
71.74
0.172


144949
ZNF313
Zinc finger protein 313
145.79
62.78
0.138


144980
SCAMP4
Secretory carrier membrane protein 4
127.39
96.37
0.345


145049
PLEKHM2
Pleckstrin homology domain containing, family M (with RUN
205.68
86.88
0.138




domain) member 2





145442
MAP2K1
Mitogen-activated protein kinase kinase 1
101.59
55.16
0.241


145575
UBL3
Ubiquitin-like 3
157.68
79.65
0.345


146070
TPM3
Tropomyosin 3
695.80
102.33
0.000


146393
HERPUD1
Homocysteine-inducible, endoplasmic reticulum stress-inducible,
226.44
86.29
0.172




ubiquitin-like domain member 1





146602
UQCRQ
Ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5 kDa
193.38
169.43
0.276


146804
SPIN1
Spindlin 1
127.00
68.69
0.345


146806
CUL1
Cullin 1
120.27
57.50
0.207


147433
PCNA
Proliferating cell nuclear antigen
258.31
133.96
0.172


148078
UBR4
Ubiquitin protein ligase E3 component n-recognin 4
144.18
73.44
0.138


148272
CCM2
Cerebral cavernous malformation 2
199.79
94.01
0.207


148330
ARF4
ADP-ribosylation factor 4
385.93
105.50
0.138


148340
PTPRG
Protein tyrosine phosphatase, receptor type, G
1592.61
150.52
0.069


148670
RHOBTB1
Rho-related BTB domain containing 1
116.95
99.14
0.345


149004
FBXO31
F-box protein 31
141.63
81.88
0.379


149957
RPS6KA1
Ribosomal protein S6 kinase, 90 kDa, polypeptide 1
146.89
140.85
0.310


149983
PEX14
Peroxisomal biogenesis factor 14
132.69
140.50
0.241


150107
BIRC6
Baculoviral IAP repeat-containing 6 (apollon)
149.90
66.77
0.345


150540
TMEM112B
Transmembrane protein 112B
180.63
177.93
0.379


150580
EIF1
Eukaryotic translation initiation factor 1
458.80
84.42
0.034


150837
TXNDC5
Thioredoxin domain containing 5
483.23
126.33
0.034


151134
OXA1L
Oxidase (cytochrome c) assembly 1-like
238.54
70.29
0.103


151220
PALLD
Palladin, cytoskeletal associated protein
198.94
75.04
0.345


151413
GMFB
Glia maturation factor beta
190.53
95.31
0.379


151787
EFTUD2
Elongation factor Tu GTP binding domain containing 2
326.78
81.27
0.069


152536
PSMD6
Proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
134.14
63.78
0.241


153177
RPS28
Ribosomal protein S28
437.53
297.35
0.241


154023
TXNDC4
Thioredoxin domain containing 4 (endoplasmic reticulum)
133.74
72.55
0.345


154073
SLC35B1
Solute carrier family 35, member B1
99.61
61.75
0.379


155165
ZFPL1
Zinc finger protein-like 1
156.23
92.72
0.310


155218
HNRPUL1
Heterogeneous nuclear ribonucleoprotein U-like 1
474.38
82.52
0.000


155396
NFE2L2
Nuclear factor (erythroid-derived 2)-like 2
182.54
63.38
0.172


155829
TBC1D9B
TBC1 domain family, member 9B (with GRAM domain)
189.13
67.14
0.241


156171
PSMC6
Proteasome (prosome, macropain) 26S subunit, ATPase, 6
202.42
86.99
0.172


156367
RPS29
Ribosomal protein S29
735.43
357.07
0.241


156667
CALCOCO
Calcium binding and coiled-coil domain 1
150.95
83.49
0.276


157160
MRPS34
Mitochondrial ribosomal protein S34
163.79
79.67
0.276


157351
GTPBP9
GTP-binding protein 9 (putative)
256.77
85.59
0.207


157379
H2AFV
H2A histone family, member V
212.94
72.40
0.138


157394
HAGH
Hydroxyacylglutathione hydrolase
110.09
79.63
0.345


159014
PRPF4B
PRP4 pre-mRNA processing factor 4 homolog B (yeast)
101.54
63.09
0.379


159118
AMD1
Adenosylmethionine decarboxylase 1
179.16
87.63
0.241


159130
RAF1
V-raf-1 murine leukemia viral oncogene homolog 1
148.50
123.34
0.138


159161
ARHGDIA
Rho GDP dissociation inhibitor (GDI) alpha
781.87
98.28
0.138


159699
FBXO21
F-box protein 21
112.15
59.46
0.345


159799
THRAP2
Thyroid hormone receptor associated protein 2
135.37
68.96
0.345


160958
CDC37
CDC37 cell division cycle 37 homolog (S. cerevisiae)
297.55
114.77
0.069


161357
PDHB
Pyruvate dehydrogenase (lipoamide) beta
188.51
80.70
0.172


162032
HBP1
HMG-box transcription factor 1
119.42
40.70
0.345


162233
CHD4
Chromodomain helicase DNA binding protein 4
294.77
95.15
0.207


162877
PACSIN2
Protein kinase C and casein kinase substrate in neurons 2
181.10
101.47
0.207


163645
MOCS2
Molybdenum cofactor synthesis 2
123.58
91.10
0.276


163776
UBE2J1
Ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)
229.95
250.60
0.310


163893
PICALM
Phosphatidylinositol binding clathrin assembly protein
153.29
84.25
0.310


165195
VAPA
VAMP (vesicle-associated membrane protein)-associated protein
170.73
76.58
0.069




A, 33 kDa





166011
CTNND1
Catenin (cadherin-associated protein), delta 1
181.39
76.07
0.138


166204
PHF1
PHD finger protein 1
128.96
77.28
0.345


166463
HNRPU
Heterogeneous nuclear ribonucleoprotein U (scaffold attachment
279.34
89.13
0.034




factor A)





166924
SEC13
SEC13 homolog (S. cerevisiae)
164.56
70.57
0.207


166975
SFRS5
Splicing factor, arginine/serine-rich 5
241.85
95.20
0.138


167535
SRP54
Signal recognition particle 54 kDa
132.08
105.35
0.241


168073
TRPC4AP
Transient receptor potential cation channel, subfamily C, member
174.32
67.74
0.241




4 associated protein





168799
METTL3
Methyltransferase like 3
133.88
65.22
0.172


169611
DIABLO
Diablo homolog (Drosophila)
167.55
69.66
0.276


169718
CNN2
Calponin 2
263.90
111.61
0.138


170107
UQCRFS1
Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide
112.20
75.09
0.241


170131
NFIC
Nuclear factor I/C (CCAAT-binding transcription factor)
128.62
75.64
0.379


170553
CNOT7
CCR4-NOT transcription complex, subunit 7
119.98
77.62
0.276


170622
CFL1
Cofilin 1 (non-muscle)
1372.26
96.41
0.034


171626
SKP1A
S-phase kinase-associated protein 1A (p19A)
457.12
128.78
0.138


172550
PTBP1
Polypyrimidine tract binding protein 1
554.08
85.76
0.103


172755
BRP44L
Brain protein 44-like
150.10
97.09
0.379


172928
COL1A1
Collagen, type I, alpha 1
657.85
170.49
0.276


173024
NUB1
Negative regulator of ubiquitin-like proteins 1
102.38
55.09
0.276


173162
COX4NB
COX4 neighbor
259.86
100.34
0.310


173381
DPYSL2
Dihydropyrimidinase-like 2
213.62
76.62
0.310


173464
FKBP8
FK506 binding protein 8, 38 kDa
446.43
105.38
0.103


173611
NDUFS2
NADH dehydrogenase (ubiquinone) Fe—S protein 2, 49 kDa
308.98
100.60
0.069




(NADH-coenzyme Q reductase)





173705
LOC40115
HCV F-transactivated protein 1
155.92
91.92
0.207


173724
CKB
Creatine kinase, brain
395.40
117.54
0.310


174050
EDF1
Endothelial differentiation-related factor 1
163.11
77.20
0.345


174195
IFITM2
Interferon induced transmembrane protein 2 (1-8D)
439.92
224.90
0.276


175473
AK1
Adenylate kinase 1
115.05
96.67
0.345


175955
YTHDC1
YTH domain containing 1
114.99
56.92
0.310


177530
ATP5E
ATP synthase, H+ transporting, mitochondrial F1 complex, epsilor
343.57
172.81
0.207




subunit





177766
PARP1
Poly (ADP-ribose) polymerase family, member 1
260.77
114.80
0.103


178551
RPL8
Ribosomal protein L8
1600.62
93.63
0.034


178728
MBD3
Methyl-CpG binding domain protein 3
226.33
93.86
0.241


179986
FLOT1
Flotillin 1
239.64
133.66
0.241


180141
CFL2
Cofilin 2 (muscle)
236.22
198.55
0.345


180312
MRPS16
Mitochondrial ribosomal protein S16
148.32
71.61
0.276


180414
HSPA8
Heat shock 70 kDa protein 8
1204.20
99.10
0.000


180877
H3F3B
H3 histone, family 3B (H3.3B)
701.35
71.33
0.000


180903
NCAPH2
Non-SMC condensin II complex, subunit H2
273.31
91.43
0.310


180909
PRDX1
Peroxiredoxin 1
973.56
146.34
0.138


180933
CXXC1
CXXC finger 1 (PHD domain)
127.97
58.18
0.345


181046
DUSP3
Dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-
168.09
115.04
0.207




related)





181112
MED4
Mediator of RNA polymerase II transcription, subunit 4 homolog
208.67
152.66
0.276




(yeast)





181163
HMGN2
High-mobility group nucleosomal binding domain 2
798.73
84.12
0.000


181244
HLA-A
Major histocompatibility complex, class I, A
874.95
96.35
0.138


181368
PRPF8
PRP8 pre-mRNA processing factor 8 homolog (yeast)
308.98
76.46
0.138


181444
TMEM9
Transmembrane protein 9
210.70
80.44
0.172


182255
NHP2L1
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
236.95
69.85
0.069


182626
C22orf5
Chromosome 22 open reading frame 5
189.45
87.32
0.310


182885
SLC35B2
Solute carrier family 35, member B2
197.27
131.49
0.241


183684
EIF4G2
Eukaryotic translation initiation factor 4 gamma, 2
571.05
99.96
0.069


183706
ADD1
Adducin 1 (alpha)
210.75
70.37
0.138


183800
RANGAP1
Ran GTPase activating protein 1
330.34
92.47
0.172


183850
DCTD
DCMP deaminase
140.58
59.00
0.345


183994
PPP1CA
Protein phosphatase 1, catalytic subunit, alpha isoform
374.52
71.55
0.103


184062
C20orf24
Chromosome 20 open reading frame 24
161.95
77.22
0.310


184211
PMPCB
Peptidase (mitochondrial processing) beta
177.15
64.50
0.138


184233
HSPA9
Heat shock 70 kDa protein 9 (mortalin)
311.24
80.92
0.034


184492
ELAVL1
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu
130.66
66.07
0.207




antigen R)





185172
GNB2
Guanine nucleotide binding protein (G protein), beta polypeptide 2
420.89
178.43
0.172


185597
SPG7
Spastic paraplegia 7, paraplegin (pure and complicated autosomal
167.10
102.17
0.207




recessive)





187199
MALAT1
Metastasis associated lung adenocarcinoma transcript 1 (non-
3984.95
243.42
0.241




coding RNA)





187635
RPS15A
Chromosome 20 open reading frame 19
705.06
435.58
0.138


187763
BRD4
Bromodomain containing 4
226.90
138.89
0.241


187866
NPTN
Neuroplastin
120.12
53.64
0.379


187946
SLC20A1
Solute carrier family 20 (phosphate transporter), member 1
141.36
96.84
0.207


188501
PAFAH1B2
Platelet-activating factor acetylhydrolase, isoform Ib, beta subunit
149.54
78.69
0.138




30 kDa





188614
PLEKHA5
Pleckstrin homology domain containing, family A member 5
115.79
66.94
0.379


188879
RBM6
RNA binding motif protein 6
100.43
54.89
0.379


188882
NUDT3
Nudix (nucleoside diphosphate linked moiety X)-type motif 3
129.54
63.13
0.276


189075
TWF1
Twinfilin, actin-binding protein, homolog 1 (Drosophila)
164.98
70.22
0.310


189119
CXXC5
CXXC finger 5
97.63
45.99
0.345


189329
SMURF1
SMAD specific E3 ubiquitin protein ligase 1
126.19
77.52
0.379


189716
NDUFAB1
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1,
224.85
87.06
0.276




8 kDa





189772
CCT2
Chaperonin containing TCP1, subunit 2 (beta)
269.61
95.66
0.069


190028
GSTO1
Glutathione S-transferase omega 1
178.51
92.79
0.241


190086
MRCL3
Myosin regulatory light chain MRCL3
469.83
322.83
0.172


190334
RAP1A
RAP1A, member of RAS oncogene family
130.79
76.47
0.310


190384
COPS4
COP9 constitutive photomorphogenic homolog subunit 4
163.76
100.38
0.138




(Arabidopsis)





190722
C19orf62
Chromosome 19 open reading frame 62
218.33
85.79
0.207


190904
STRN4
Striatin, calmodulin binding protein 4
183.13
100.67
0.241


191186
TTC17
Tetratricopeptide repeat domain 17
125.42
63.68
0.310


191346
SEPT7
Septin 7
318.59
80.82
0.103


191518
DHX9
DEAH (Asp-Glu-Ala-His) box polypeptide 9
239.90
67.53
0.241


191987
UBE2J2
Ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast)
125.95
71.90
0.207


192316
CDC2L1
Cell division cycle 2-like 1 (PITSLRE proteins)
102.48
85.83
0.379


192374
HSP90B1
Heat shock protein 90 kDa beta (Grp94), member 1
388.12
88.21
0.034


192425
EIF3S8
Eukaryotic translation initiation factor 3, subunit 8, 110 kDa
1001.22
91.36
0.103


193118
ZMIZ1
Zinc finger, MIZ-type containing 1
125.42
71.59
0.345


193163
BIN1
Bridging integrator 1
216.65
88.45
0.241


193491
TUBB6
Tubulin, beta 6
255.15
94.70
0.241


194329
TCEAL4
Transcription elongation factor A (SII)-like 4
110.76
60.41
0.207


194718
ZRANB2
Zinc finger, RAN-binding domain containing 2
170.63
70.34
0.207


195464
FLNA
Filamin A, alpha (actin binding protein 280)
554.90
92.75
0.172


195642
RNF213
Ring finger protein 213
146.02
74.10
0.379


196983
SSFA2
Sperm specific antigen 2
238.74
197.56
0.241


198281
PKM2
Pyruvate kinase, muscle
3044.33
101.80
0.000


199561
RANBP2
RAN binding protein 2
134.09
59.13
0.379


199625
HAX1
HCLS1 associated protein X-1
243.58
94.74
0.138


200063
HDAC7A
Histone deacetylase 7A
252.27
159.81
0.241


200600
SCAMP3
Secretory carrier membrane protein 3
165.58
75.71
0.207


200804
SDCBP
Syndecan binding protein (syntenin)
355.16
73.99
0.172


201253
CKAP5
Cytoskeleton associated protein 5
157.71
77.53
0.069


201390
WDR45L
WDR45-like
115.15
53.09
0.138


201712
GLG1
Golgi apparatus protein 1
128.23
88.99
0.310


202011
CCDC47
Coiled-coil domain containing 47
108.62
67.48
0.172


202085
VDAC1
Voltage-dependent anion channel 1
179.22
70.07
0.276


202166
HNRPH1
Heterogeneous nuclear ribonucleoprotein H1 (H)
199.33
74.31
0.069


202179
SMN2
Survival of motor neuron 1, telomeric
103.17
55.27
0.379


203099
WAPAL
Wings apart-like homolog (Drosophila)
162.13
143.02
0.345


203910
SGTA
Small glutamine-rich tetratricopeptide repeat (TPR)-containing,
213.58
79.65
0.138




alpha





204041
AHSA1
AHA1, activator of heat shock 90 kDa protein ATPase homolog 1
263.29
112.20
0.207




(yeast)





204773
WDR77
WD repeat domain 77
185.81
74.28
0.172


205163
MRPL3
Mitochondrial ribosomal protein L3
176.93
58.08
0.069


206500
CTTN
Cortactin
148.63
96.70
0.310


206824
MGC71993
Similar to DNA segment, Chr 11, Brigham & Womens
143.54
88.77
0.345




Genetics 0434 expressed





208597
CTBP1
Hypothetical protein LOC285463
136.74
48.53
0.138


209983
STMN1
Stathmin 1/oncoprotein 18
619.09
139.81
0.034


210469
ELMO2
Engulfment and cell motility 2 (ced-12 homolog, C. elegans)
96.39
71.43
0.379


210532
KIAA0141
KIAA0141
138.36
72.99
0.241


211463
DNM2
Dynamin 2
195.67
87.32
0.241


211594
PSMC4
Proteasome (prosome, macropain) 26S subunit, ATPase, 4
469.59
192.26
0.138


211914
NDUFS7
NADH dehydrogenase (ubiquinone) Fe—S protein 7, 20 kDa
159.44
73.80
0.379




(NADH-coenzyme Q reductase)





212102
PDIA6
Protein disulfide isomerase family A, member 6
274.17
97.91
0.103


212395
CIZ1
CDKN1A interacting zinc finger protein 1
272.61
88.59
0.138


213061
NUCKS1
Nuclear casein kinase and cyclin-dependent kinase substrate 1
304.71
64.96
0.138


213470
PSMB7
Proteasome (prosome, macropain) subunit, beta type, 7
247.81
65.94
0.034


213541
LOC55288
Hypothetical LOC552889
136.06
60.14
0.345


213666
KIAA0460
KIAA0460
96.71
78.04
0.241


213724
SUPT16H
Suppressor of Ty 16 homolog (S. cerevisiae)
149.27
79.71
0.207


216653
FBXO9
F-box protein 9
92.27
49.72
0.310


220950
FOXO3
Forkhead box O3
196.88
112.74
0.276


221847
SLC38A2
Solute carrier family 38, member 2
204.23
78.33
0.207


222510
DAZAP1
DAZ associated protein 1
126.05
97.18
0.276


223141
DDX21
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
255.54
70.08
0.069


224607
SDC1
Syndecan 1
241.65
87.87
0.276


226007
RDH11
Retinol dehydrogenase 11 (all-trans and 9-cis)
340.36
135.94
0.172


226117
H1F0
H1 histone family, member 0
326.85
160.18
0.310


226755
YWHAH
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
199.21
161.02
0.207




activation protein, eta polypeptide





227067
ATAD3A
ATPase family, AAA domain containing 3A
254.68
105.30
0.172


227253
TOMM70A
Translocase of outer mitochondrial membrane 70 homolog A
130.67
67.31
0.172




(yeast)





227777
PTP4A1
Protein tyrosine phosphatase type IVA, member 1
219.08
115.20
0.138


229641
SUB1
SUB1 homolog (S. cerevisiae)
300.51
103.71
0.138


231295
PITPNC1
Phosphatidylinositol transfer protein, cytoplasmic 1
171.09
127.31
0.345


231616
C19orf53
Chromosome 19 open reading frame 53
162.05
104.55
0.345


232194
KIAA0174
KIAA0174
204.24
73.78
0.138


232543
PDCD4
Programmed cell death 4 (neoplastic transformation inhibitor)
126.25
61.41
0.310


233458
NFYC
Nuclear transcription factor Y, gamma
92.20
51.11
0.345


233552
CDC2L5
Cell division cycle 2-like 5 (cholinesterase-related cell division
139.27
109.94
0.379




controller)





233952
PSMA7
Proteasome (prosome, macropain) subunit, alpha type, 7
358.81
133.21
0.069


234521
MAPKAPK3
Mitogen-activated protein kinase-activated protein kinase 3
185.75
77.03
0.379


236030
SMARCC2
SWI/SNF related, matrix associated, actin dependent regulator of
198.07
83.50
0.207




chromatin, subfamily c, member 2





237536
NT5C3L
5′-nucleotidase, cytosolic III-like
160.67
84.27
0.276


237971
XTP3TPA
XTP3-transactivated protein A
122.34
67.16
0.276


238839
SCYL1
SCY1-like 1 (S. cerevisiae)
173.16
113.72
0.310


240170
OBFC2B
Oligonucleotide/oligosaccharide-binding fold containing 2B
136.42
69.86
0.345


241336
ATPIF1
ATPase inhibitory factor 1
227.40
125.29
0.172


241543
POLDIP2
Polymerase (DNA-directed), delta interacting protein 2
217.98
81.62
0.138


241558
ARIH2
Ariadne homolog 2 (Drosophila)
178.45
77.54
0.172


241575
GNPTG
N-acetylglucosamine-1-phosphate transferase, gamma subunit
117.17
100.69
0.345


241576
DERL1
Der1-like domain family, member 1
111.58
87.37
0.310


241579
SERPINH1
Serpin peptidase inhibitor, clade H (heat shock protein 47),
380.44
115.76
0.172




member 1, (collagen binding protein 1)





242458
SPG21
Spastic paraplegia 21 (autosomal recessive, Mast syndrome)
120.35
59.44
0.310


242947
DGKI
Diacylglycerol kinase, iota
131.75
120.70
0.379


246112
ASCC3L1
Activating signal cointegrator 1 complex subunit 3-like 1
278.46
81.24
0.172


246310
ATP5J
ATP synthase, H+ transporting, mitochondrial F0 complex, subuni
220.45
113.90
0.276




F6





246413
CPNE1
RNA binding motif protein 12
392.42
88.16
0.069


246781
FBXO11
F-box protein 11
141.20
92.55
0.379


247077
RHOA
Ras homolog gene family, member A
553.79
77.72
0.034


247186
FBRS
Fibrosin
145.20
107.50
0.379


247975
HSPD1
Pro-melanin-concentrating hormone-like 1
241.69
85.58
0.207


248267
MPST
Mercaptopyruvate sulfurtransferase
167.67
112.86
0.276


248941
TAF9
TAF9 RNA polymerase II, TATA box binding protein (TBP)-
148.14
65.92
0.276




associated factor, 32 kDa





249600
DLGAP4
Discs, large (Drosophila) homolog-associated protein 4
233.49
169.10
0.276


250009
ARL8B
ADP-ribosylation factor-like 8B
132.27
55.79
0.379


250429
SUPT6H
Suppressor of Ty 6 homolog (S. cerevisiae)
162.25
82.76
0.379


250758
PSMC3
Proteasome (prosome, macropain) 26S subunit, ATPase, 3
391.11
115.64
0.138


250899
HSBP1
Heat shock factor binding protein 1
214.94
105.83
0.069


250905
TMEM85
Transmembrane protein 85
156.08
143.74
0.241


251531
PSMA4
Proteasome (prosome, macropain) subunit, alpha type, 4
739.81
217.34
0.138


252457
MVD
Mevalonate (diphospho) decarboxylase
170.93
117.34
0.379


252713
TTC15
Tetratricopeptide repeat domain 15
105.62
56.20
0.345


252967
C1orf144
Chromosome 1 open reading frame 144
240.90
109.65
0.207


253726
PAPOLA
Poly(A) polymerase alpha
216.15
65.36
0.172


253903
STOM
Stomatin
199.17
100.65
0.276


254042
BAT1
HLA-B associated transcript 1
351.44
89.43
0.069


255015
VPS24
Vacuolar protein sorting 24 (yeast)
126.82
67.80
0.069


255093
PFKL
Phosphofructokinase, liver
342.69
81.83
0.207


255932
XRN2
5′-3′ exoribonuclease 2
166.16
57.70
0.069


255935
BTG1
B-cell translocation gene 1, anti-proliferative
272.14
115.44
0.138


255973
EID1
EP300 interacting inhibitor of differentiation 1
227.90
86.79
0.138


256301
C19orf48
Chromosome 19 open reading frame 48
337.67
84.54
0.207


256549
NUBP2
Nucleotide binding protein 2 (MinD homolog, E. coli)
200.75
98.94
0.241


257008
PLD3
Phospholipase D family, member 3
349.21
100.00
0.276


257341
SAV1
Salvador homolog 1 (Drosophila)
91.57
65.55
0.276


257761
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
170.93
92.54
0.345


258551
DNPEP
Aspartyl aminopeptidase
168.16
84.05
0.138


258563
FEZ2
Fasciculation and elongation protein zeta 2 (zygin II)
190.19
204.72
0.345


258798
NSMCE4A
Non-SMC element 4 homolog A (S. cerevisiae)
79.52
52.34
0.345


259461
PALM2-
PALM2-AKAP2 protein
171.91
79.41
0.310



AKAP2






260603
PIP5K2B
Phosphatidylinositol-4-phosphate 5-kinase, type II, beta
132.75
67.00
0.276


262823
IARS2
Isoleucyl-tRNA synthetase 2, mitochondrial
139.24
59.53
0.345


265829
ITGA3
Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3
404.31
148.83
0.379




receptor)





268488
LRRC47
Leucine rich repeat containing 47
115.89
116.32
0.379


268530
GPS1
Radical fringe homolog (Drosophila)
263.51
64.58
0.138


268742
POMP
Proteasome maturation protein
213.22
98.49
0.276


268849
GLO1
Glyoxalase I
293.88
85.24
0.138


268939
MATR3
Matrin 3
292.73
68.23
0.034


269528
NAT13
N-acetyltransferase 13
237.37
198.20
0.172


269577
PTPRA
Protein tyrosine phosphatase, receptor type, A
183.68
82.75
0.207


269782
GNAQ
Guanine nucleotide binding protein (G protein), q polypeptide
174.12
105.06
0.241


269944
MTCH2
Mitochondrial carrier homolog 2 (C. elegans)
158.42
74.35
0.103


270291
ACTN4
Actinin, alpha 4
341.13
108.40
0.172


270428
SUCLG1
Succinate-CoA ligase, GDP-forming, alpha subunit
242.34
241.99
0.241


270525
LASS5
LAG1 longevity assurance homolog 5 (S. cerevisiae)
111.31
73.14
0.379


270869
ZNF410
Zinc finger protein 410
135.77
84.28
0.172


271135
ATP5C1
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma
448.47
176.19
0.172




polypeptide 1





271695
NOB1
NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)
111.46
73.07
0.310


272062
PTPRF
Protein tyrosine phosphatase, receptor type, F
269.10
88.46
0.310


272168
SERINC3
Serine incorporator 3
121.11
72.44
0.138


272630
ATP6V1D
ATPase, H+ transporting, lysosomal 34 kDa, V1 subunit D
149.33
85.72
0.207


272927
SEC23A
Sec23 homolog A (S. cerevisiae)
128.24
74.07
0.379


273077
TMEM14B
Transmembrane protein 14B
128.20
70.29
0.345


274184
TFE3
Transcription factor binding to IGHM enhancer 3
111.31
57.20
0.276


274772
C15orf15
Chromosome 15 open reading frame 15
1163.64
205.16
0.172


274873
CARS
Cysteinyl-tRNA synthetase
176.72
76.48
0.207


275243
S100A6
S100 calcium binding protein A6 (calcyclin)
361.59
101.08
0.103


275775
SEPP1
Selenoprotein P, plasma, 1
543.33
189.21
0.379


275865
PCNP
PEST-containing nuclear protein
315.34
88.79
0.069


276878
NUP93
Nucleoporin 93 kDa
101.32
60.26
0.241


277035
MGLL
Monoglyceride lipase
399.51
211.97
0.379


277517
C11orf2
Chromosome 11 open reading frame 2
193.83
84.84
0.241


278186
ARHGEF1
Rho guanine nucleotide exchange factor (GEF) 1
194.28
91.63
0.345


278362
MEA1
Male-enhanced antigen 1
152.60
83.00
0.276


278426
PDAP1
PDGFA associated protein 1
184.93
86.49
0.172


278429
C9orf78
Chromosome 9 open reading frame 78
109.74
79.17
0.276


278500
GNPDA1
Glucosamine-6-phosphate deaminase 1
174.64
74.75
0.241


278569
SNX17
Sorting nexin 17
297.66
66.25
0.069


278573
CD59
CD59 antigen p18-20 (antigen identified by monoclonal antibodies
336.75
91.21
0.138




16.3A5, EJ16, EJ30, EL32 and G344)





278721
SLC39A7
Solute carrier family 39 (zinc transporter), member 7
147.65
72.58
0.379


279061
GLOD4
Glyoxalase domain containing 4
148.90
76.66
0.172


279245
TACC1
Transforming, acidic coiled-coil containing protein 1
186.16
79.86
0.241


279257
PCMT1
Protein-L-isoaspartate (D-aspartate) O-methyltransferase
172.73
62.20
0.103


279413
POLD1
Polymerase (DNA directed), delta 1, catalytic subunit 125 kDa
164.91
99.93
0.276


279529
PRELID1
PRELI domain containing 1
224.95
77.28
0.172


279583
METTL9
Methyltransferase like 9
183.44
155.70
0.241


279623
SEPX1
Selenoprotein X, 1
117.70
54.66
0.345


279640
TPR
Translocated promoter region (to activated MET oncogene)
94.90
66.61
0.310


279652
MRPL4
Mitochondrial ribosomal protein L4
173.40
73.00
0.276


279669
TUBG1
Tubulin, gamma 1
169.58
65.01
0.310


279696
SUMF2
Sulfatase modifying factor 2
149.85
83.02
0.345


279806
DDX5
RNA-binding protein 45 (RBP45), putative
457.60
87.95
0.103


279836
COMMD9
COMM domain containing 9
104.98
49.94
0.379


279920
YWHAB
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
288.39
87.94
0.034




activation protein, beta polypeptide





279929
TMED9
Transmembrane emp24 protein transport domain containing 9
291.55
91.04
0.069


280202
SBF1
SET binding factor 1
382.01
317.21
0.310


280342
PRKAR1A
Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue
266.02
111.27
0.103




specific extinguisher 1)





280378
SNRPB2
Small nuclear ribonucleoprotein polypeptide B′′
243.47
100.43
0.310


282410
CALM1
Calmodulin 1 (phosphorylase kinase, delta)
246.78
67.76
0.103


282700
SPCS2
Signal peptidase complex subunit 2 homolog (S. cerevisiae)
232.99
84.36
0.207


282901
RBM39
RNA binding motif protein 39
166.92
85.70
0.138


282998
RBM9
RNA binding motif protein 9
477.00
221.29
0.103


283111
C14orf124
Chromosome 14 open reading frame 124
168.06
139.52
0.207


283454
BNIP2
BCL2/adenovirus E1B 19 kDa interacting protein 2
130.03
68.79
0.310


283521
RHEB
Ras homolog enriched in brain
193.25
113.28
0.310


283610
ATG4B
ATG4 autophagy related 4 homolog B (S. cerevisiae)
180.36
88.44
0.172


283652
IDI1
Isopentenyl-diphosphate delta isomerase 1
233.34
102.32
0.241


283739
UBQLN4
Ubiquilin 4
165.35
84.58
0.207


284208
ANKRD25
Ankyrin repeat domain 25
124.68
85.84
0.379


284279
HMOX2
Heme oxygenase (decycling) 2
151.53
85.91
0.310


284286
MRPS24
Mitochondrial ribosomal protein S24
136.83
77.51
0.345


284491
PDXK
Pyridoxal (pyridoxine, vitamin B6) kinase
235.50
93.74
0.138


285354
MAX
MYC associated factor X
109.16
60.60
0.345


285976
LASS2
LAG1 longevity assurance homolog 2 (S. cerevisiae)
203.17
82.28
0.172


286221
ARF1
ADP-ribosylation factor 1
704.87
66.67
0.069


286226
MYO1C
Myosin IC
253.69
114.87
0.310


288193
KPNA4
Karyopherin alpha 4 (importin alpha 3)
144.60
134.58
0.379


288856
PFDN5
Prefoldin 5
226.65
96.63
0.103


288969
NMRAL1
NmrA-like family domain containing 1
126.04
77.91
0.379


289008
NUS1
Nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)
157.63
95.67
0.310


289092
COTL1
Coactosin-like 1 (Dictyostelium)
315.93
109.13
0.172


289123
DCTN2
Dynactin 2 (p50)
261.39
105.34
0.069


289271
CYC1
Cytochrome c-1
345.69
78.79
0.172


290243
GBF1
Golgi-specific brefeldin A resistance factor 1
241.54
85.11
0.310


290404
SLC25A3
Solute carrier family 25 (mitochondrial carrier; phosphate carrier),
1579.85
87.93
0.034




member 3





290758
DDB1
Damage-specific DNA binding protein 1, 127 kDa
452.78
82.29
0.138


291587
ARID1B
AT rich interactive domain 1B (SWI1-like)
135.97
82.06
0.310


292026
EIF4E2
Eukaryotic translation initiation factor 4E member 2
186.78
88.38
0.138


292063
EIF4B
Hypothetical protein PRO1843
439.43
110.97
0.103


292078
LARP1
La ribonucleoprotein domain family, member 1
246.82
65.22
0.069


292265
ZMYND11
Zinc finger, MYND domain containing 11
133.13
109.13
0.207


292457
SNHG5
Small nucleolar RNA host gene (non-protein coding) 5
400.14
267.50
0.276


292493
XRCC6
X-ray repair complementing defective repair in Chinese hamster
691.10
100.07
0.034




cells 6 (Ku autoantigen, 70 kDa)





292524
CCNH
Cyclin H
158.48
96.80
0.276


292579
PTDSS1
Phosphatidylserine synthase 1
195.76
80.55
0.276


293563
C1orf108
Chromosome 1 open reading frame 108
144.99
87.81
0.172


295917
ATP6V1B2
ATPase, H+ transporting, lysosomal 56/58 kDa, V1 subunit B,
151.09
76.58
0.207




isoform 2





297324
TIMP3
TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy,
505.19
227.34
0.310




pseudoinflammatory)





298198
CMTM3
CKLF-like MARVEL transmembrane domain containing 3
127.34
71.77
0.310


298280
ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha
1791.25
357.36
0.000




subunit, isoform 1, cardiac muscle





298654
DUSP6
Dual specificity phosphatase 6
208.26
87.60
0.310


299002
FBL
Fibrillarin
591.46
179.47
0.138


299055
GDI2
GDP dissociation inhibitor 2
323.73
77.59
0.069


300141
RPL39
Ribosomal protein L39
775.36
419.08
0.172


300684
RCP9
Calcitonin gene-related peptide-receptor component protein
79.62
45.89
0.241


300772
TPM2
Tropomyosin 2 (beta)
881.72
370.12
0.345


300816
RAB1B
RAB1B, member RAS oncogene family
228.92
96.00
0.172


300834
GALNT2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-
155.76
89.15
0.241




acetylgalactosaminyltransferase 2 (GalNAc-T2)





301404
RBM3
RNA binding motif (RNP1, RRM) protein 3
325.81
102.69
0.172


301412
UFC1
Ubiquitin-fold modifier conjugating enzyme 1
142.19
76.03
0.276


302742
MRPS6
Mitochondrial ribosomal protein S6
184.15
77.33
0.276


302903
UBE2I
Ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
178.40
82.89
0.172


303676
G3BP2
Ras-GTPase activating protein SH3 domain-binding protein 2
149.92
66.30
0.241


304192
DSTN
Destrin (actin depolymerizing factor)
223.11
77.62
0.207


304682
CST3
Cystatin C (amyloid angiopathy and cerebral hemorrhage)
266.47
126.42
0.172


306123
MAGEF1
Melanoma antigen family F, 1
183.67
83.29
0.379


306242
RANBP9
RAN binding protein 9
116.92
67.43
0.310


306329
ZFAND6
Zinc finger, AN1-type domain 6
247.28
99.07
0.276


306425
IBTK
Inhibitor of Bruton agammaglobulinemia tyrosine kinase
104.18
51.87
0.379


308122
ITPK1
Inositol 1,3,4-triphosphate 5/6 kinase
254.52
81.30
0.276


308340
NUP188
Nucleoporin 188 kDa
329.72
144.04
0.241


308709
PDIA3
Protein disulfide isomerase family A, member 3
204.27
87.48
0.069


309090
SFRS7
Splicing factor, arginine/serine-rich 7, 35 kDa
189.69
89.49
0.172


309231
C6orf153
Chromosome 6 open reading frame 153
157.44
80.31
0.310


309641
RNF11
Ring finger protein 11
162.82
68.82
0.172


309753
STARD3NL
STARD3 N-terminal like
119.30
74.99
0.310


309849
C14orf159
Chromosome 14 open reading frame 159
122.74
74.53
0.379


310542
TOMM40
Translocase of outer mitochondrial membrane 40 homolog (yeast)
267.48
79.87
0.138


310645
RAB1A
RAB1A, member RAS oncogene family
252.99
84.41
0.241


311072
MRPS35
Mitochondrial ribosomal protein S35
138.81
64.82
0.345


311346
CMAS
Cytidine monophosphate N-acetylneuraminic acid synthetase
109.31
97.45
0.345


311609
DDX39
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39
260.02
110.28
0.138


311640
RPS27A
Ribosomal protein S27a
524.64
119.16
0.034


312098
ADAM15
ADAM metallopeptidase domain 15 (metargidin)
200.26
132.76
0.345


313847
TXNDC11
Thioredoxin domain containing 11
106.99
71.40
0.345


314263
BAZ2A
Bromodomain adjacent to zinc finger domain, 2A
164.92
91.68
0.241


314359
EIF3S12
Eukaryotic translation initiation factor 3, subunit 12
248.91
116.13
0.103


315177
IFRD2
Interferon-related developmental regulator 2
180.25
60.11
0.276


315230
EIF1B
Eukaryotic translation initiation factor 1B
166.77
108.63
0.207


319334
NASP
Nuclear autoantigenic sperm protein (histone-binding)
320.92
87.44
0.103


321391
ELOF1
Elongation factor 1 homolog (S. cerevisiae)
119.51
68.26
0.345


321541
RAB11A
RAB11A, member RAS oncogene family
193.82
99.65
0.172


323363
ATG9A
ATG9 autophagy related 9 homolog A (S. cerevisiae)
159.62
88.11
0.276


323489
PTCD3
Pentatricopeptide repeat domain 3
153.29
80.62
0.172


324250
NDUFB2
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8 kDa
245.74
182.66
0.379


324844
VKORC1
Vitamin K epoxide reductase complex, subunit 1
151.74
66.24
0.276


325650
EHD2
EH-domain containing 2
160.03
99.53
0.379


326387
MORF4L2
Mortality factor 4 like 2
313.02
109.69
0.103


330384
CORO1C
Coronin, actin binding protein, 1C
171.53
69.53
0.103


331431
SCC-112
SCC-112 protein
242.38
75.28
0.069


333388
EEF1D
Eukaryotic translation elongation factor 1 delta (guanine nucleotide
899.57
105.63
0.000




exchange protein)





333579
HSPC152
Hypothetical protein HSPC152
209.20
133.84
0.172


333786
PSMA2
Proteasome (prosome, macropain) subunit, alpha type, 2
207.24
97.57
0.138


333823
MRPL13
Mitochondrial ribosomal protein L13
113.33
69.75
0.345


334017
TUBA1B
Tubulin, alpha 1b
1834.27
95.82
0.000


334479
TRAF7
TNF receptor-associated factor 7
242.13
130.36
0.138


334534
GNS
Glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID)
129.18
72.76
0.276


334587
RBPMS
RNA binding protein with multiple splicing
136.68
59.93
0.345


334713
UBL7
Ubiquitin-like 7 (bone marrow stromal cell-derived)
192.75
67.45
0.207


334851
LASP1
LIM and SH3 protein 1
297.69
80.06
0.034


334868
PPP2R5E
Protein phosphatase 2, regulatory subunit B (B56), epsilon isoform
111.74
78.51
0.345


335003
ANKRD11
Ankyrin repeat domain 11
152.63
135.85
0.276


335057
SEPT2
Septin 2
321.01
90.60
0.069


335163
LIMCH1
LIM and calponin homology domains 1
217.46
84.47
0.379


335918
FDPS
Farnesyl diphosphate synthase (farnesyl pyrophosphate
635.55
104.20
0.034




synthetase, dimethylallyltranstransferase, geranyltranstransferase





337295
STIP1
Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing
326.55
78.19
0.172


337766
TXNRD1
Thioredoxin reductase 1
641.30
103.44
0.034


339278
COPB1
Coatomer protein complex, subunit beta 1
144.35
59.14
0.241


339639
COX7A2L
Cytochrome c oxidase subunit VIIa polypeptide 2 like
222.21
84.81
0.241


339697
GRINA
Glutamate receptor, ionotropic, N-methyl D-asparate-associated
287.06
90.28
0.103




protein 1 (glutamate binding)





343911
EI24
Etoposide induced 2.4 mRNA
172.38
72.77
0.103


345694
KCMF1
Potassium channel modulatory factor 1
114.01
57.72
0.345


346868
EBNA1BP2
EBNA1 binding protein 2
190.81
79.22
0.276


348418
DR1
Down-regulator of transcription 1, TBP-binding (nagative cofactor
109.41
77.62
0.207


349656
SCARB2
Scavenger receptor class B, member 2
147.31
89.03
0.241


350194
ZMAT2
Zinc finger, matrin type 2
115.49
53.42
0.207


350229
CASC3
Cancer susceptibility candidate 3
124.19
53.21
0.241


350268
IRF2BP2
Interferon regulatory factor 2 binding protein 2
153.03
81.62
0.276


350364
FAM120AOS
Family with sequence similarity 120A opposite strand
107.30
65.11
0.379


350927
SLC25A6
Solute carrier family 25 (mitochondrial carrier; adenine nucleotide
952.99
85.55
0.000




translocator), member 6





351099
FLJ10241
Hypothetical protein FLJ10241
126.93
65.83
0.276


351296
LOC51035
SAPK substrate protein 1
210.44
71.71
0.172


351316
TM4SF1
Transmembrane 4 L six family member 1
422.43
110.13
0.276


351474
PAQR4
Progestin and adipoQ receptor family member IV
212.87
153.70
0.345


351680

CDNA clone IMAGE: 5302006
133.19
88.88
0.276


351875
COX6C
Cytochrome c oxidase subunit VIc
304.69
180.70
0.310


352341
STCH
Stress 70 protein chaperone, microsome-associated, 60 kDa
121.74
86.32
0.379


352656
GHITM
Growth hormone inducible transmembrane protein
363.92
99.19
0.103


352768
PSMB1
Proteasome (prosome, macropain) subunit, beta type, 1
292.02
82.24
0.103


354056
POR
P450 (cytochrome) oxidoreductase
227.09
82.79
0.379


355141
TNIP1
TNFAIP3 interacting protein 1
269.81
97.79
0.241


355606
TMEM167
Transmembrane protein 167
211.08
149.60
0.276


355643
RNPS1
RNA binding protein S1, serine-rich domain
423.42
65.75
0.103


355708
TMEM127
Transmembrane protein 127
77.31
49.24
0.379


355750
JOSD3
Josephin domain containing 3
117.50
61.17
0.379


355753
AGPAT6
1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic
150.13
73.56
0.345




acid acyltransferase, zeta)





355867
MARS
Methionine-tRNA synthetase
323.10
233.26
0.069


355927
VDAC2
Voltage-dependent anion channel 2
242.40
82.56
0.103


355934
SFPQ
Splicing factor proline/glutamine-rich (polypyrimidine tract binding
269.46
133.96
0.138




protein associated)





355983
BZW1
Basic leucine zipper and W2 domains 1
338.32
108.39
0.103


356061
MAP1LC3B
Microtubule-associated protein 1 light chain 3 beta
126.69
74.25
0.207


356096
MAP7D1
MAP7 domain containing 1
191.33
92.49
0.207


356190
UBB
Ubiquitin B
742.69
74.99
0.000


356270
SDHD
Succinate dehydrogenase complex, subunit D, integral membrane
977.72
187.08
0.207




protein





356285
HMGN1
High-mobility group nucleosome binding domain 1
279.36
80.39
0.138


356331
PPIA
Peptidylprolyl isomerase A (cyclophilin A)
1225.70
78.02
0.034


356366
RPS2
Ribosomal protein S2
5031.59
91.00
0.000


356371
RPL28
Ribosomal protein L28
622.10
176.27
0.034


356377
RNF187
Ring finger protein 187
188.84
96.73
0.207


356467
C19orf42
Chromosome 19 open reading frame 42
148.32
80.69
0.034


356501
PHF6
PHD finger protein 6
145.65
87.04
0.310


356502
RPLP1
Ribosomal protein, large, P1
881.03
208.46
0.000


356549
SNRPD3
Small nuclear ribonucleoprotein D3 polypeptide 18 kDa
153.63
84.17
0.276


356630
NUTF2
Nuclear transport factor 2
144.29
83.13
0.103


356647
SNX6
Sorting nexin 6
134.10
84.57
0.310


356654
PSMC1
Proteasome (prosome, macropain) 26S subunit, ATPase, 1
154.97
82.94
0.172


356766
C20orf199
Chromosome 20 open reading frame 199
227.51
154.61
0.310


356769
MAN2B1
Mannosidase, alpha, class 2B, member 1
166.87
97.57
0.310


356799
RPL41
Ribosomal protein L41
336.21
165.15
0.345


357901
SOX4
SRY (sex determining region Y)-box 4
163.64
90.74
0.345


362728
SEP15
15 kDa selenoprotein
302.87
139.54
0.138


365116
U2AF1
U2(RNU2) small nuclear RNA auxiliary factor 1
152.30
63.70
0.241


368084
LRPPRC
Leucine-rich PPR-motif containing
180.31
95.65
0.241


368149
CCT7
Chaperonin containing TCP1, subunit 7(eta)
968.98
94.04
0.069


368157
PYGB
Phosphorylase, glycogen; brain
289.40
94.26
0.241


368240
DYRK1A
Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
132.39
93.19
0.379


368264
PPP2R5C
Protein phosphatase 2, regulatory subunit B (B56), gamma
235.30
135.72
0.103


368376
SRPR
Signal recognition particle receptor (‘docking protein’)
170.10
91.17
0.138


368402
C8orf55
Chromosome 8 open reading frame 55
129.24
75.63
0.379


368404
EXT2
Exostoses (multiple) 2
144.25
80.41
0.345


368525
PDLIM1
PDZ and LIM domain 1 (elfin)
285.39
113.52
0.241


368598
ZC3H15
Zinc finger CCCH-type containing 15
153.03
73.26
0.172


368934
C17orf45
Chromosome 17open reading frame 45
538.27
122.37
0.103


368985
TRIP12
Thyroid hormone receptor interactor 12
160.59
66.50
0.345


369017
RAB2A
RAB2A, member RAS oncogene family
185.09
87.27
0.172


369052
SELT
Selenoprotein T
368.37
150.53
0.172


369068
DYNC1LI2
Dynein, cytoplasmic 1, light intermediate chain 2
158.56
97.53
0.138


369125
PSMD14
Proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
166.50
83.15
0.103


369285
INTS7
Integrator complex subunit 7
112.06
98.19
0.379


369356
MLL5
Myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog,
156.73
73.07
0.276




Drosophila)





369606
CPSF6
Cleavage and polyadenylation specific factor 6, 68 kDa
132.90
65.76
0.207


369607
GAK
Cyclin G associated kinase
139.66
91.16
0.379


369614
COPS2
COP9 constitutive photomorphogenic homolog subunit 2
138.58
64.46
0.241




(Arabidopsis)





369615
SLC25A38
Solute carrier family 25, member 38
148.69
73.93
0.345


369761
DAZAP2
DAZ associated protein 2
432.10
77.51
0.069


369785
C19orf50
Chromosome 19 open reading frame 50
176.53
91.76
0.207


369920
RAP1B
RAP1B, member of RAS oncogene family
160.45
86.70
0.138


370024
SEC31A
SEC31 homolog A (S. cerevisiae)
162.54
73.78
0.138


370247
APLP2
Amyloid beta (A4) precursor-like protein 2
331.96
98.29
0.207


370292
BCCIP
BRCA2 and CDKN1A interacting protein
116.14
69.62
0.172


370312
FNTA
Farnesyltransferase, CAAX box, alpha
113.75
73.97
0.172


370408
COMT
Catechol-O-methyltransferase
269.48
182.45
0.138


370581
CAP1
CAP, adenylate cyclase-associated protein 1 (yeast)
429.82
79.15
0.069


370770
XPO1
Exportin 1 (CRM1 homolog, yeast)
218.71
75.18
0.172


370771
CDKN1A
Cyclin-dependent kinase inhibitor 1A (p21, Cip1)
406.91
129.23
0.207


370895
RPN2
Ribophorin II
431.77
115.24
0.069


370927
LRRC59
Leucine rich repeat containing 59
338.69
149.06
0.138


370937
TAPBP
TAP binding protein (tapasin)
159.24
70.81
0.310


371001
EIF3S9
Eukaryotic translation initiation factor 3, subunit 9 eta, 116 kDa
343.76
63.64
0.103


371416
CARM1
Coactivator-associated arginine methyltransferase 1
186.54
108.72
0.276


371563
RAB14
RAB14, member RAS oncogene family
154.08
65.54
0.310


371788
C1orf77
Chromosome 1 open reading frame 77
121.36
60.36
0.207


371889
ATP1A1
Hypothetical protein MGC16179
910.43
156.53
0.069


372003
FAM120A
Family with sequence similarity 120A
211.67
121.79
0.241


372050
YIPF5
Yip1 domain family, member 5
117.56
66.39
0.276


372286
CUL3
Cullin 3
131.34
66.77
0.207


372331
SPTAN1
Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
187.03
76.74
0.207


372541
KBTBD2
Kelch repeat and BTB (POZ) domain containing 2
100.18
63.32
0.310


372616
ARL1
ADP-ribosylation factor-like 1
107.60
50.60
0.345


372914
NDRG1
N-myc downstream regulated gene 1
214.33
101.47
0.241


373550
TGIF1
TGFB-induced factor homeobox 1
109.97
67.30
0.379


373741
HM13
Histocompatibility (minor) 13
280.09
120.85
0.069


373763
HNRPR
Heterogeneous nuclear ribonucleoprotein R
210.83
74.59
0.103


373952
CAMTA2
Calmodulin binding transcription activator 2
181.38
88.37
0.345


373959
VGLL4
Vestigial like 4 (Drosophila)
141.11
70.42
0.310


374043
ASXL1
Additional sex combs like 1 (Drosophila)
130.97
88.31
0.241


374257
LOC28616
Hypothetical protein LOC286167
151.79
112.19
0.276


374378
CKS1B
CDC28 protein kinase regulatory subunit 1B
179.04
67.28
0.172


374477
EWSR1
Ewing sarcoma breakpoint region 1
423.33
116.42
0.069


374503
MORF4L1
Mortality factor 4 like 1
292.45
60.67
0.069


374588
RPL17
Ribosomal protein L17
907.22
138.52
0.034


374596
TPT1
Tumor protein, translationally-controlled 1
987.59
77.14
0.034


374650
IFITM3
Interferon induced transmembrane protein 3 (1-8U)
366.99
97.80
0.276


374973
PRPF4
PRP4 pre-mRNA processing factor 4 homolog (yeast)
103.66
65.33
0.207


375001
TLN1
Talin 1
392.09
120.61
0.138


375108
CD24
CD24 antigen (small cell lung carcinoma cluster 4 antigen)
239.14
95.21
0.310


375217
RNF31
Ring finger protein 31
104.06
73.05
0.379


376046
BTN3A2
Butyrophilin, subfamily 3, member A2
149.93
123.05
0.310


376933
GUK1
Guanylate kinase 1
401.68
92.59
0.276


377155
MTDH
Metadherin
214.89
91.52
0.138


378103
RPS5
Ribosomal protein S5
1006.11
134.01
0.069


378532
HBS1L
HBS1-like (S. cerevisiae)
131.17
80.02
0.241


378808
EIF2A
Eukaryotic translation initiation factor 2A, 65 kDa
197.55
75.77
0.138


380403
BMI1
BMI1 polycomb ring finger oncogene
103.02
59.56
0.276


380774
DDX3X
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
183.86
64.56
0.241


380953
RPL38
Ribosomal protein L38
472.88
260.03
0.138


380973
SUMO2
SMT3 suppressor of mif two 3 homolog 2 (yeast)
634.74
241.40
0.103


381008
HLA-E
Major histocompatibility complex, class I, E
476.57
108.00
0.103


381058
KIAA0146
KIAA0146 protein
136.13
82.82
0.276


381072
PPIF
Peptidylprolyl isomerase F (cyclophilin F)
236.14
96.10
0.034


381123
RPL21
Ribosomal protein L21
1087.11
152.34
0.069


381126
RPS14
Ribosomal protein S14
312.13
120.35
0.172


381189
CBX3
Chromobox homolog 3 (HP1 gamma homolog Drosophila)
352.70
90.90
0.138


381219
RPL15
Ribosomal protein L15
454.76
118.60
0.034


381256
GLTP
Glycolipid transfer protein
107.14
53.95
0.379


382044
MRPS2
Mitochondrial ribosomal protein S2
171.06
80.19
0.207


382168
NCOA3
Nuclear receptor coactivator 3
166.37
135.20
0.345


385913
ANP32E
Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
183.06
71.26
0.345


385986
UBE2B
Ubiquitin-conjugating enzyme E2B (RAD6 homolog)
135.72
71.52
0.345


386434
ANXA7
Annexin A7
173.87
70.85
0.138


386465
CHERP
Calcium homeostasis endoplasmic reticulum protein
177.08
80.21
0.345


386939
USP7
Ubiquitin specific peptidase 7 (herpes virus-associated)
181.20
217.36
0.207


387208
FAU
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV)
336.62
163.47
0.103




ubiquitously expressed (fox derived); ribosomal protein S30





387804
PABPC1
Poly(A) binding protein, cytoplasmic 1
625.68
87.04
0.000


388034
RXRB
Retinoid X receptor, beta
142.87
89.88
0.310


388654
ATP6V1G1
ATPase, H+ transporting, lysosomal 13 kDa, V1 subunit G isoform 1
234.65
112.64
0.172


388664
RPL11
Ribosomal protein L11
672.13
137.34
0.034


388739
XRCC5
X-ray repair complementing defective repair in Chinese hamster
346.39
73.79
0.034




cells 5 (double-strand-break rejoining; Ku autoantigan, 80 kDa)





388927
YY1
YY1 transcription factor
136.53
65.73
0.103


388956
C19orf22
Chromosome 19 open reading frame 22
133.57
84.00
0.345


389037
MCM3APAS
MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
152.46
115.81
0.207




associated protein





389107
ATP6V0C
ATPase, H+ transporting, lysosomal 16 kDa, V0 subunit c
237.34
79.84
0.172


389171
PINK1
PTEN induced putative kinase 1
126.44
98.97
0.207


389649
EIF4A3
Eukaryotic translation initiation factor 4A, isoform 3
193.85
75.13
0.138


389734
TCEAL8
Transcription elongation factor A (SII)-like 8
155.08
72.63
0.345


389996
CHCHD2
Coiled-coil-helix-coiled-coil-helix domain containing 2
373.11
68.47
0.034


390667
GSTK1
Glutathione S-transferase kappa 1
168.35
104.34
0.241


393201
ACTR2
ARP2 actin-related protein 2 homolog (yeast)
328.49
139.01
0.172


395482
PTK2
PTK2 protein tyrosine kinase 2
177.88
103.98
0.207


396644
PAIP2
Poly(A) binding protein interacting protein 2
198.13
69.25
0.103


396740
NIP30
NEFA-interacting nuclear protein NIP30
96.64
53.08
0.241


396783
SLC9A3R1
Solute carrier family 9 (sodium/hydrogen exchanger), member 3
165.70
98.11
0.276




regulator 1





397609
RPS16
Ribosomal protein S16
1470.38
224.21
0.069


399800
AKAP8L
A kinase (PRKA) anchor protein 8-like
166.62
90.19
0.310


400295
RPL30
Ribosomal protein L30
473.07
139.61
0.103


401509
RBM10
RNA binding motif protein 10
170.05
75.56
0.172


401903
COX5A
Cytochrome c oxidase subunit Va
149.97
93.76
0.379


401929
RPL10
Ribosomal protein L10
1521.64
147.31
0.000


403917
STK24
Serine/threonine kinase 24 (STE20 homolog, yeast)
150.48
84.52
0.276


404056
EIF3S1
Eukaryotic translation initiation factor 3, subunit 1 alpha, 35 kDa
140.93
90.80
0.310


404321
GARS
Glycyl-tRNA synthetase
247.29
80.31
0.034


405144
SFRS3
Splicing factor, arginine/serine-rich 3
526.80
137.87
0.034


405410
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-
153.55
55.45
0.379




acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)





405514
KIAA1267
KIAA1267
114.08
65.11
0.345


405590
EIF3S6
Eukaryotic translation initiation factor 3, subunit 6 48 kDa
654.44
113.72
0.069


405880
MRPS21
Mitochondrial ribosomal protein S21
141.88
82.93
0.276


405942
CCDC137
Coiled-coil domain containing 137
133.03
86.11
0.241


406062
NDUFA11
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7 kDa
173.17
93.80
0.345


406068
UBE2M
Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)
132.46
80.88
0.345


406096
ZFAND5
Zinc finger, AN1-type domain 5
192.43
93.38
0.345


406277
SF3A1
Splicing factor 3a, subunit 1, 120 kDa
296.74
89.39
0.276


406300
RPL23
Ribosomal protein L23
696.30
308.79
0.069


406423
SF3B2
Splicing factor 3b, subunit 2, 145 kDa
355.96
73.17
0.069


406510
ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta
1002.07
88.90
0.034




polypeptide





406520
LOC38954
Similar to CG14977-PA
124.27
87.28
0.276


406534
HMG20B
High-mobility group 20B
281.92
155.98
0.103


406590
MRFAP1
Mof4 family associated protein 1
256.02
73.95
0.207


406620
RPS10
Ribosomal protein S10
1185.80
153.87
0.034


406683
RPS15
Ribosomal protein S15
521.25
123.23
0.069


406799
RAB18
RAB18, member RAS oncogene family
127.87
57.58
0.310


406840
SLC35A4
Solute carrier family 35, member A4
186.45
71.30
0.103


407368
LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
151.28
68.77
0.207


407580
PKP4
Plakophilin 4
130.61
101.53
0.207


407995
MIF
Macrophage migration inhibitory factor (glycosylation-inhibiting
520.62
161.06
0.241




factor)





408018
RPL36
Ribosomal protein L36
426.58
200.20
0.276


408073
RPS6
Ribosomal protein S6
1753.93
92.01
0.034


408236
TXNL5
Thioredoxin-like 5
137.51
78.57
0.276


408257
NDUFS6
NADH dehydrogenase (ubiquinone) Fe—S protein 6, 13 kDa
167.98
115.41
0.379




(NADH-coenzyme Q reductase)





408293
CEP170
Centrosomal protein 170 kDa
95.55
57.63
0.379


408324
FLJ10769
Hypothetical protein FLJ10769
179.63
110.86
0.345


408428
FOXN3
Forkhead box N3
171.98
93.85
0.379


408581
SVIL
Supervillin
150.79
78.33
0.276


408909
GOLPH3
Golgi phosphoprotein 3 (coat-protein)
149.55
90.99
0.207


409140
ATP5O
ATP synthase, H+ transporting, mitochondrial F1 complex, O
238.76
77.50
0.138




subunit (oligomycin sensitivity conferring protein)





409223
SSR4
Signal sequence receptor, delta (translocon-associated protein
187.19
88.00
0.138




delta)





409230
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic
188.83
78.43
0.207




acid acyltransferase, alpha)





409834
PHPT1
Phosphohistidine phosphatase 1
129.72
80.15
0.379


410197
IDH3G
Isocitrate dehydrogenase 3 (NAD+) gamma
142.89
74.63
0.276


410596
WDR68
WD repeat domain 68
190.39
78.19
0.069


410817
RPL13
Ribosomal protein L13
1259.59
96.20
0.034


411480
AUP1
Ancient ubiquitous protein 1
197.34
72.07
0.103


411641
EIF4EBP1
Eukaryotic translation initiation factor 4E binding protein 1
185.54
87.93
0.310


411847
MAPK6
Mitogen-activated protein kinase 6
143.89
100.65
0.207


412103
EFHA1
EF-hand domain family, member A1
130.69
68.19
0.276


412117
ANXA6
Annexin A6
173.96
90.66
0.172


412196
IFT57
Intraflagellar transport 57 homolog (Chlamydomonas)
109.98
56.91
0.379


412433
AIP
Aryl hydrocarbon receptor interacting protein
157.20
76.87
0.207


412468
KLHDC3
Kelch domain containing 3
366.49
77.49
0.172


412842
CDC123
Cell division cycle 123 homolog (S. cerevisiae)
155.00
62.20
0.207


413036
WBSCR22
Williams Beuren syndrome chromosome region 22
181.29
80.06
0.103


413482
C21orf33
Chromosome 21 open reading frame 33
220.73
103.88
0.172


414579
SCOTIN
Scotin
344.80
79.60
0.138


415342
TCF25
Transcription factor 25 (basic helix-loop-helix)
132.99
67.57
0.172


416049
TNPO2
Transportin 2 (importin 3, karyopherin beta 2b)
121.80
74.72
0.345


416436
TRIM50
Tripartite motif-containing 50
253.97
118.36
0.138


417004
S100A11
S100 calcium binding protein A11 (calgizzarin)
282.02
146.47
0.138


417029
C17orf81
Chromosome 17 open reading frame 81
116.93
60.21
0.379


418123
CTSLL3
Cathepsin L-like 3
196.99
151.69
0.345


418175
VPS28
Vacuolar protein sorting 28 (yeast)
137.80
101.08
0.345


418233
MRPL24
Mitochondrial ribosomal protein L24
111.66
117.93
0.345


418450
MRPL11
Mitochondrial ribosomal protein L11
169.41
63.02
0.310


418533
BUB3
BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
180.32
113.91
0.172


418668
ATP5D
ATP synthase, H+ transporting, mitochondrial F1 complex, delta
142.90
94.88
0.276




subunit





419640
PARK7
Parkinson disease (autosomal recessive, early onset) 7
255.09
75.95
0.172


420269
COL6A2
Collagen, type VI, alpha 2
425.15
132.41
0.379


420272
H2AFY
H2A histone family, member Y
236.54
78.85
0.069


421257
RPL7
Ribosomal protein L7
148.01
111.08
0.138


421509
CCT4
Chaperonin containing TCP1, subunit 4 (delta)
245.54
69.17
0.138


422113
ZNF511
Zinc finger protein 511
92.03
40.84
0.379


423935
RDBP
RD RNA binding protein
114.07
56.49
0.241


423968
F1S1
Fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
140.14
94.84
0.379


424126
SERF2
Small EDRK-rich factor 2
421.90
169.35
0.103


424908
LSM5
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
118.18
94.48
0.310


425777
UBE2L6
Ubiquitin-conjugating enzyme E2L 6
176.08
83.76
0.345


426296
C10orf104
Chromosome 10 open reading frame 104
193.46
94.72
0.207


426359
PRR13
proline rich 13
204.04
77.90
0.345


429052
ITGB1
Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen
343.25
71.08
0.207




CD29 includes MDF2, MSK12)





429353
SEPN1
Selenoprotein N, 1
163.54
91.46
0.241


429581
RTN4
Reticulon 4
587.74
263.68
0.069


429819
PITPNA
Phosphatidylinositol transfer protein, alpha
132.54
66.33
0.241


429839
BTF3L4
Basic transcription factor 3-like 4
128.62
88.13
0.379


430425
GNB1
Guanine nucleotide binding protein (G protein), beta polypeptide 1
348.68
72.19
0.069


430551
IQGAP1
IQ motif containing GTPase activating protein 1
168.69
68.30
0.241


430606
CS
Citrate synthase
377.31
109.46
0.034


430657
ARF5
ADP-ribosylation factor 5
184.36
99.34
0.310


430733
CLNS1A
Chloride channel, nucleotide-sensitive, 1A
147.58
71.03
0.207


431101
GNG12
Guanine nucleotide binding protein (G protein), gamma 12
197.95
72.99
0.310


431367
VTA1
Vps20-associated 1 homolog (S. cerevisiae)
154.26
81.47
0.172


431498
FOXP1
Forkhead box P1
158.95
84.08
0.345


431550
MAP4K4
Mitogen-activated protein kinase kinase kinase kinase 4
150.49
75.85
0.241


431668
COX6B1
Cytochrome c oxidase subunit Vib polypeptide 1 (ubiquitous)
249.30
171.30
0.207


431850
MAPK1
Mitogen-activated protein kinase 1
147.43
68.90
0.241


431861
PPP5C
Protein phosphatase 5, catalytic subunit
203.35
97.62
0.138


431926
NFKB1
Nuclear factor of kappa light polypeptide gene enhancer in B-cells
118.70
65.79
0.310




1 (p105)





432121
PRDX2
Peroxiredoxin 2
328.05
98.46
0.069


432438
EML4
Echinoderm microtubule associated protein like 4
127.17
67.00
0.345


432491
ESD
Esterase D/formylglutathione hydrolase
181.49
81.57
0.103


432690
SLC39A9
Solute carrier family 39 (zinc transporter), member 9
123.27
74.29
0.207


432760
CAPZB
Capping protein (actin filament) muscle Z-line, beta
189.76
70.34
0.069


432898
RPL4
Mitogen-activated protein kinase kinase kinase 13
2173.97
96.68
0.000


432976
NR1H2
Nuclear receptor subfamily 1, group H, member 2
190.02
112.04
0.241


433154
PLSCR3
Phospholipid scramblase 3
118.46
78.13
0.345


433201
CDK2AP1
CDK2-associated protein 1
137.33
80.77
0.241


433222
NPC2
Niemann-Pick disease, type C2
218.82
98.64
0.069


433291
ARD1A
ARD1 homolog A, N-acetyltransferase (S. cerevisiae)
119.07
75.05
0.207


483307
BCKDHA
Branched chain keto acid dehydrogenase E1, alpha polypeptide
166.35
84.74
0.379




(maple syrup urine disease)





433343
SRRM2
Serine/arginine repetitive matrix 2
179.81
99.94
0.103


433345

Full-length cDNA clone CL0BB014ZH04 of Neuroblastoma of
131.69
72.43
0.241




Homo sapiens (human)





433419
COX4I1
Cytochrome c oxidase subunit IV isoform 1
291.96
97.81
0.103


433512
ACTR3
ARP3 actin-related protein 3 homolog (yeast)
202.84
72.82
0.103


433529
RPS11
Ribosomal protein S11
659.56
130.65
0.069


433540
DNAJC8
DnaJ (Hsp40) homolog, subfamily C, member 8
164.57
66.59
0.172


433573
C11orf68
Chromosome 11 open reading frame 68
109.74
74.58
0.379


433615
TUBB2C
Tubulin, beta 2C
1313.99
109.59
0.034


433701
RPL37A
Ribosomal protein L37a
941.22
280.38
0.034


433722
KIAA1967
KIAA1967
137.26
57.51
0.345


433732
CLK1
CDC-like kinase 1
179.68
71.24
0.379


433750
EIF4G1
Eukaryotic translation initiation factor 4 gamma, 1
509.92
79.20
0.138


433759
BANF1
Barrier to autointegration factor 1
185.36
115.51
0.103


433795
SHC1
SHC (Src homology 2 domain containing) transforming protein 1
307.01
110.48
0.103


433863
PEBP1
Phosphatidylethanolamine binding protein 1
349.44
89.20
0.034


433901
COX8A
Cytochrome c oxidase subunit 8A (ubiquitous)
335.34
202.06
0.207


433951
GPX4
Glutathione peroxidase 4 (phospholipid hydroperoxidase)
265.60
84.94
0.207


434102
HMGB1
High-mobility group box 1
638.86
104.01
0.000


434207
HARS2
Histidyl-tRNA synthetase 2
146.76
94.43
0.276


434219
ANKHD1
Ankyrin repeat and KH domain containing 1
190.31
76.42
0.103


434401
ZNF638
Zinc finger protein 638
127.61
80.05
0.276


434937
PPIB
Peptidylprolyl isomerase B (cyclophilin B)
258.12
78.54
0.069


434953
HMGB2
High-mobility group box 2
275.63
95.40
0.138


434980
APP
Amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer's
228.56
92.10
0.172




disease)





435044
TBC1D22A
TBC1 domain family, member 22A
160.02
137.97
0.310


435064
DENND1A
DENN/MADD domain containing 1A
99.58
55.26
0.379


435120
KIF1C
Kinesin family member 1C
210.09
68.46
0.241


435136
TXN
Thioredoxin
346.61
189.66
0.276


435166
LBR
Lamin B receptor
188.22
185.85
0.310


435231
ZFR
Zinc finger RNA binding protein
158.35
73.83
0.172


435255
UBXD1
UBX domain containing 1
173.66
118.04
0.241


435326
ACTL6A
Actin-like 6A
152.42
64.63
0.172


435512
PPP3CA
Protein phosphatase 3 (formerly 2B), catalytic subunit, alpha
156.63
85.19
0.345




isoform (calcineurin A alpha)





435535
ZNF395
Zinc finger protein 395
126.06
79.86
0.310


435610
WAC
WW domain containing adaptor with coiled-coil
197.21
111.45
0.172


435741
GCSH
IQ motif and WD repeats 1
165.11
72.41
0.138


435759
THAP4
THAP domain containing 4
133.58
83.98
0.379


435771
API5
Apoptosis inhibitor 5
191.29
106.97
0.276


435841
TNRC15
Trinucleotide repeat containing 15
115.02
60.28
0.310


435850
LYPLA1
Lysophospholipase I
278.94
98.93
0.138


435933
PHF10
Chromosome 6 open reading frame 120
160.27
71.75
0.276


435948
ATAD1
ATPase family, AAA domain containing 1
119.77
79.07
0.310


435952
CDK5RAP1
CDK5 regulatory subunit associated protein 1
122.11
83.77
0.310


435974
MTHFD1
Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1,
193.28
103.81
0.172




methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate







synthetase





436035
TUBA1C
Tubulin, alpha 1c
3419.68
98.12
0.000


436093
BAT2
HLA-B associated transcript 2
414.35
96.65
0.172


436204
ZNF289
Zinc finger protein 289, ID1 regulated
187.48
70.10
0.138


436298
EMP1
Epithelial membrane protein 1
139.81
90.61
0.310


436405
IDH3B
Isocitrate dehydrogenase 3 (NAD+) beta
233.17
64.64
0.172


436437
ALDH2
Aldehyde dehydrogenase 2 family (mitochondrial)
213.99
91.66
0.207


436446
ARMET
Arginine-rich, mutated in early stage tumors
238.76
107.79
0.379


436500
DBNL
Drebrin-like
322.18
106.61
0.241


436568
CD74
CD74 antigen (invariant polypeptide of major histocompatibility
3672.46
211.82
0.345




complex, class II antigen-associated)





436578
POLR2F
Polymerase (RNA) II (DNA directed) polypeptide F
106.90
73.50
0.345


436657
CLU
Clusterin (complement lysis inhibitor, SP-40,40, sulfated
586.91
158.76
0.241




glycoprotein 2, testosterone-repressed prostate message 2,







apolipoprotein J)





436687
SET
SET translocation (myeloid leukemia-associated)
285.02
84.84
0.034


436803
VBP1
Von Hippel-Lindau binding protein 1
182.84
93.52
0.207


437056
SUPT5H
Suppressor of Ty 5 homolog (S. cerevisiae)
216.64
117.71
0.207


437060
CYCS
Cytochrome c, somatic
1874.90
252.41
0.207


437110
ANXA2
Annexin A2
2060.10
130.61
0.034


437178
ACADVL
Acyl-Coenzyme A dehydrogenase, very long chain
288.37
92.69
0.069


437256
GRINL1A
Glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A
151.07
83.14
0.345


437277
MGAT4B
Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-
1083.50
147.46
0.103




acetylglucosaminyltransferase, isoenzyme B





437367
GBAS
Glioblastoma amplified sequence
143.22
113.71
0.276


437388
PIGT
Phosphatidylinositol glycan, class T
227.91
106.45
0.103


437403
PPA1
Pyrophosphatase (inorganic) 1
159.06
72.02
0.138


437594
RPLP2
Ribosomal protein, large, P2
498.18
148.73
0.034


437638
XBP1
X-box binding protein 1
319.21
100.78
0.069


437779
C11orf10
Chromosome 11 open reading frame 10
241.39
149.44
0.345


437831
C14orf32
Chromosome 14 open reading frame 32
175.37
74.13
0.241


438072
UNC84A
Unc-84 homolog A (C. elegans)
146.52
82.20
0.345


438219
GPS2
G protein pathway suppressor 2
172.78
109.64
0.172


438429
RPS19
Ribosomal protein S19
721.53
169.75
0.103


438678
TALDO1
Transaldolase 1
280.29
75.06
0.138


438720
MCM7
MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
548.49
107.89
0.138


438970
TBL1XR1
Transducin (beta)-like 1X-linked receptor 1
185.70
86.87
0.241


438974
CUTL1
Cut-like 1, CCAAT displacement protein (Drosophila)
159.65
95.91
0.310


439480
RBM5
RNA binding motif protein 5
145.24
117.34
0.379


439481
SUPT4H1
Suppressor of Ty 4 homolog 1 (S. cerevisiae)
139.55
62.12
0.207


439548
FAM96A
Family with sequence similarity 96, member A
155.35
85.81
0.241


439552
MAP2K3
Mitogen-activated protein kinase kinase 3
2617.77
147.47
0.000


439815
HBXIP
Hepatitis B virus x interacting protein
127.08
97.39
0.310


440382
TRIM27
Tripartite motif-containing 27
155.33
68.54
0.172


440544
CLIC4
Chloride intracellular channel 4
337.71
121.54
0.103


440599
DDX1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
433.83
283.30
0.103


440604
PSMD7
Proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
156.07
77.17
0.138




(Mov34 homolog)





440899
TTYH3
Tweety homolog 3 (Drosophila)
229.54
97.64
0.172


440932
SEPT9
Septin 9
361.78
96.86
0.034


440960
RAD23A
RAD23 homolog A (S. cerevisiae)
214.38
69.61
0.207


440961
CAST
Calpastatin
194.31
90.01
0.207


441072
POLR2L
Polymerase (RNA) II (DNA directed) polypeptide L, 7.6 kDa
225.44
138.68
0.379


441550
ABHD12
Abhydrolase domain containing 12
215.47
106.70
0.241


442344
IRS2
Insulin receptor substrate 2
134.97
79.52
0.379


442798
RNF10
Ring finger protein 10
210.73
75.43
0.103


443134
GBA2
Glucosidase, beta (bile acid) 2
132.85
60.27
0.379


443379
PSMD11
Proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
180.98
64.45
0.172


443837
NPEPPS
Aminopeptidase puromycin sensitive
173.54
73.65
0.172


443914
SOD1
Superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1
341.06
88.95
0.103




(adult))





444279
GPBP1
GC-rich promoter binding protein 1
132.98
56.92
0.241


444356
GRB2
Growth factor receptor-bound protein 2
167.92
61.94
0.172


444468
CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A
187.59
76.37
0.241




small phosphatase 1





444472
SDHC
Succinate dehydrogenase complex, subunit C, integral membrane
175.42
71.22
0.207




protein, 15 kDa





444569
TMEM49
Transmembrane protein 49
212.58
83.31
0.241


444673
CLPTM1L
CLPTM1-like
229.08
106.76
0.207


444724
AZI2
5-azacytidine induced 2
132.28
73.71
0.345


444818
CGGBP1
CGG triplet repeat binding protein 1
177.53
83.72
0.241


444931
CRSP6
Cofactor required for Sp1 transcriptional activation, subunit 6, 77 kDa
88.71
48.78
0.379


444969
MEMO1
Mediator of cell motility 1
96.52
59.19
0.276


444986
METAP2
Methionyl aminopeptidase 2
169.09
73.08
0.172


445081
OAF
OAF homolog (Drosophila)
113.21
58.71
0.345


445351
LGALS1
Lectin, galactoside-binding, soluble, 1 (galectin 1)
564.16
197.93
0.241


445394
VPS29
Vacuolar protein sorting 29 (yeast)
276.97
108.32
0.138


445498
SNW1
SNW domain containing 1
143.71
69.55
0.138


445511
RIOK3
RIO kinase 3 (yeast)
110.92
105.70
0.379


445570
CD63
CD63 antigen (melanoma 1 antigen)
489.45
199.49
0.034


445803
DC2
DC2 protein
658.16
215.09
0.138


445893
KHDRBS1
KH domain containing, RNA binding, signal transduction
227.64
88.75
0.138




associated 1





445977
GTF3A
General transcription factor IIIA
160.66
73.81
0.172


446017
WSB1
WD repeat and SOCS box-containing 1
239.91
93.71
0.276


446091
WTAP
Wilms tumor 1 associated protein
119.70
95.46
0.379


446123
CAPZA2
Capping protein (actin filament) muscle Z-line, alpha 2
370.83
95.48
0.138


446149
LDHB
Lactate dehydrogenase B
1544.78
120.53
0.000


446260
PSMA6
Proteasome (prosome, macropain) subunit, alpha type, 6
224.07
106.72
0.172


446336
PXN
Paxillin
259.56
97.96
0.138


446345
FTH1
Ferritin, heavy polypeptide 1
2359.77
133.58
0.034


446414
CD47
CD47 antigen (Rh-related antigen, integrin-associated signal
165.59
95.67
0.310




transducer)





446427
OAZ1
Ornithine decarboxylase antizyme 1
673.68
62.71
0.069


446445
YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
151.87
80.99
0.276


446450
ITM2B
Integral membrane protein 2B
511.62
115.21
0.138


446574
TMSB10
Thymosin beta 10
524.43
177.08
0.103


446588
RPS13
Ribosomal protein S13
183.34
95.13
0.345


446623
HNRPL
Heterogeneous nuclear ribonucleoprotein L
113.61
53.54
0.276


446628
RPS4X
Ribosomal protein S4, X-linked
1285.06
89.84
0.000


446641
ARAF
V-raf murine sarcoma 3611 viral oncogene homolog
176.49
69.57
0.241


446852
EIF3S6IP
Eukaryotic translation initiation factor 3, subunit 6 interacting
925.97
188.87
0.034




protein





447477
ST13
Suppression of tumorigenicity 13 (colon carcinoma) (Hsp70
272.29
141.17
0.103




interacting protein)





447492
PGAM1
Phosphoglycerate mutase 1 (brain)
781.46
84.70
0.034


447547
VPS35
Hypothetical protein MGC34800
195.14
67.15
0.103


448226
RPLP0
Ribosomal protein, large, P0
3809.20
75.92
0.000


448588
NGFRAP1
Nerve growth factor receptor (TNFRSF16) associated protein 1
218.09
83.14
0.310


448646
RPL27A
Ribosomal protein L27a
766.60
139.37
0.276


448879
LOC38834
similar to ribosomal protein L13
471.24
99.11
0.069


449114
HNRPC
Heterogeneous nuclear ribonucleoprotein C (C1/C2)
803.24
90.38
0.034


449171
HNRPK
Heterogeneous nuclear ribonucleoprotein K
403.79
69.90
0.034


454534
USF2
Upstream transcription factor 2, c-fos interacting
111.98
76.53
0.310


454699
IL6ST
Interleukin 6 signal transducer (gp130, oncostatin M receptor)
266.74
139.73
0.103


456507
KIAA0319L
KIAA0319-like
131.45
85.77
0.241


456557
C1orf164
chromosome 1 open reading frame 164
143.89
71.60
0.276


458320
C3orf37
chromosome 3 open reading frame 37
170.49
148.07
0.310


458358
TSPYL1
Squamous cell carcinoma antigen recognized by T cells 2
101.91
73.81
0.345


458414
IFITM1
Interferon induced transmembrane protein 1 (9-27)
278.31
223.88
0.345


458458
FAM108A1
Family with sequence similarity 108, member A1
149.77
96.59
0.276


458747
ANP32A
Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
197.57
100.71
0.172


459106
AZIN1
Antizyme inhibitor 1
209.63
95.22
0.207


459149
BTBD1
BTB (POZ) domain containing 1
136.20
84.67
0.310


459174
FAM91A1
Family with sequence similarity 91, member A1
133.90
80.72
0.379


459211
AKAP13
A kinase (PRKA) anchor protein 13
217.52
97.30
0.310


459596
MPG
N-methylpurine-DNA glycosylase
110.09
94.77
0.241


459649
CLCN7
Chloride channel 7
161.09
107.31
0.207


459927
PTMA
Prothymosin, alpha (gene sequence 28)
1066.55
86.69
0.000


459940
LITAF
Lipopolysaccharide-induced TNF factor
184.70
98.75
0.069


460238
SH3GLB2
SH3-domain GRB2-like endophilin B2
146.60
86.41
0.207


460317
SETX
Senataxin
132.56
111.94
0.310


460336
GGA2
Golgi associated, gamma adaptin ear containing, ARF binding
253.27
171.03
0.241




protein 2





460468
XPO6
Exportin 6
212.84
80.39
0.172


460499
ATXN2L
Ataxin 2-like
228.25
84.67
0.310


460574
LOC12444
Hypothetical protein BC017488
125.84
87.37
0.379


460923
CNOT1
CCR4-NOT transcription complex, subunit 1
173.85
65.75
0.207


460929
GOT2
Glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate
397.62
79.42
0.103




aminotransferase 2)





460978
APPBP1
Amyloid beta precursor protein binding protein 1
133.67
64.71
0.241


461047
G6PD
Glucose-6-phosphate dehydrogenase
274.16
130.32
0.207


461131
CYB5B
Cytochrome b5 type B (outer mitochondrial membrane)
192.30
75.56
0.138


461361
CFDP1
Craniofacial development protein 1
111.79
67.73
0.310


461379
GABARAPL2
GABA(A) receptor-associated protein-like 2
122.55
63.48
0.345


461722
TRAPPC2L
Trafficking protein particle complex 2-like
97.91
62.09
0.379


461777
CHMP1A
Chromatin modifying protein 1A
171.31
77.92
0.207


461896
CRK
V-crk sarcoma virus CT10 oncogene homolog (avian)
158.10
68.61
0.276


461925
RPA1
Replication protein A1, 70 kDa
160.13
72.42
0.103


462035
UBE2G1
Ubiquitin-conjugating enzyme E2G1 (UBC7 homolog, yeast)
149.46
102.82
0.207


462086
RPAIN
RPA interacting protein
129.54
77.35
0.379


462306
UBE2S
Ubiquitin-conjugating enzyme E2S
216.54
74.27
0.310


462316
TTC19
Hypothetical protein LOC125150
116.49
89.17
0.241


462492
USP22
Ubiquitin specific peptidase 22
379.95
165.78
0.138


462550
PIGS
Phosphatidylinositol glycan, class S
164.57
97.00
0.345


462956
PPARBP
PPAR binding protein
106.51
76.59
0.379


462998
IGFBP4
Insulin-like growth factor binding protein 4
345.88
87.71
0.207


463010
SMARCE1
SWI/SNF related, matrix associated, actin dependent regulator of
173.85
56.13
0.069




chromatin, subfamily e, member 1





463035
FKBP10
FK506 binding protein 10, 65 kDa
164.51
91.24
0.310


463041
RERE
Arginine-glutamic acid dipeptide (RE) repeats
200.18
92.99
0.276


463059
STAT3
Signal transducer and activator of transcription 3 (acute-phase
205.74
114.93
0.207




response factor)





463295
CDC27
Cell division cycle 27
115.34
79.50
0.310


463506
AKAP1
A kinase (PRKA) anchor protein 1
124.11
52.64
0.345


463702
BCAS3
Breast carcinoma amplified sequence 3
98.88
74.57
0.379


463797
MRTO4
mRNA turnover 4 homolog (S. cerevisiae)
142.20
59.85
0.276


464071
PGD
Phosphogluconate dehydrogenase
338.78
85.70
0.138


464137
ACOX1
Acyl-Coenzyme A oxidase 1, palmitoyl
103.04
66.74
0.241


464210
SYNGR2
Synaptogyrin 2
348.69
97.83
0.276


464336
P4HB
Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-
859.74
89.54
0.069




hydroxylase), beta polypeptide (protein disulfide isomerase-







associated 1)





464438
AGTRAP
Angiotensin II receptor-associated protein
117.55
68.62
0.379


464472
MRLC2
Myosin regulatory light chain MRLC2
233.35
102.50
0.034


464595
PPP4R1
Protein phosphatase 4, regulatory subunit 1
181.18
80.16
0.241


464652
TNFSF5IP1
Tumor necrosis factor superfamily, member 5-induced protein 1
145.59
119.46
0.345


464912
P15RS
Hypothetical protein FLJ10656
142.03
83.19
0.276


465224
NARS
Asparaginyl-tRNA synthetase
220.96
70.84
0.103


465374
EFHD2
EF-hand domain family, member D2
265.91
113.85
0.241


465498
TXNL4A
Thioredoxin-like 4A
121.61
80.29
0.276


465529
MIDN
Midnolin
139.65
96.07
0.345


465543
BTBD2
BTB (POZ) domain containing 2
204.49
98.92
0.207


465627
MAP2K2
Mitogen-activated protein kinase kinase 2
154.59
85.81
0.310


465645
C19orf10
Chromosome 19 open reading frame 10
204.93
79.48
0.276


465808
HNRPM
Heterogeneous nuclear ribonucleoprotein M
258.95
99.76
0.103


465849
PIN1
Protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
121.36
61.35
0.310


465924
SDHB
Succinate dehydrogenase complex, subunit B, iron sulfur (lp)
161.79
65.94
0.241


466044
PKN1
Protein kinase N1
252.31
87.50
0.276


466088
TPM4
Tropomyosin 4
139.00
71.29
0.345


466148
NR2F6
Nuclear receptor subfamily 2, group F, member 6
179.12
94.04
0.379


466471
GPI
Glucose phosphate isomerase
502.15
94.80
0.069


466693
SIRT2
Sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
214.11
113.63
0.379


466766
LTBP4
Latent transforming growth factor beta binding protein 4
174.46
77.33
0.379


466775
SNRPA
Small nuclear ribonucleoprotein polypeptide A
196.94
63.74
0.138


467084
EIF4G3
Eukaryotic translation initiation factor 4 gamma, 3
102.77
64.71
0.310


467097
SNRP70
Small nuclear ribonucleoprotein 70 kDa polypeptide (RNP antigen)
294.48
80.04
0.103


467192
PPP2R1A
Protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65)
475.55
80.67
0.069




alpha isoform





467279
LENG4
Leukocyte receptor cluster (LRC) member 4
315.24
116.72
0.310


467284
RPS9
Ribosomal protein S9
986.04
73.58
0.069


467408
TRIM28
Tripartite motif-containing 28
715.33
79.78
0.138


467637
CDC42
Cell division cycle 42 (GTP binding protein, 25 kDa)
158.07
97.05
0.138


467696
HPCAL1
Hippocalcin-like 1
172.64
83.71
0.379


467701
ODC1
Ornithine decarboxylase 1
351.16
77.30
0.103


467807
LAPTM4A
Lysosomal-associated protein transmembrane 4 alpha
482.50
88.89
0.069


467824
PUM2
Pumilio homolog 2 (Drosophila)
153.26
86.50
0.207


467960
RAB10
RAB10, member RAS oncogene family
162.79
57.31
0.103


468018
PPP1CB
Protein phosphatase 1, catalytic subunit, beta isoform
203.84
64.65
0.207


468415
PIGF
Phosphatidylinositol glycan, class F
150.01
71.46
0.241


468442
CALM2
Calmodulin 2 (phosphorylase kinase, delta)
1841.31
235.41
0.000


468760
AFTPH
Aftiphilin
93.25
61.52
0.310


469022
DGUOK
Deoxyguanosine kinase
116.26
75.71
0.241


469171
C1orf160
Chromosome 1 open reading frame 160
116.05
66.17
0.172


469331
STARD7
START domain containing 7
312.84
91.19
0.138


469820
RALB
V-ral simian leukemia viral oncogene homolog B (ras related; GTF
125.95
59.65
0.379




binding protein)





469863
YWHAZ
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
385.89
74.53
0.034




activation protein, zeta polypeptide





469925
FAM128B
Family with sequence similarity 128, member B
157.81
62.74
0.345


469970
SFRS4
Splicing factor, arginine/serine-rich 4
134.13
54.16
0.310


470091
YWHAE
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
330.87
97.70
0.069




activation protein, epsilon polypeptide





470233
ARL5A
ADP-ribosylation factor-like 5A
137.43
81.25
0.345


470417
PEF1
Penta-EF-hand domain containing 1
144.07
63.57
0.241


470477
PTP4A2
Protein tyrosine phosphatase type IVA, member 2
163.45
69.99
0.103


470577
EIF2S2
Eukaryotic translation initiation factor 2, subunit 2 beta, 38 kDa
175.54
98.23
0.379


470588
KPNA6
Karyopherin alpha 6 (importin alpha 7)
105.07
66.63
0.207


470943
STAT1
Signal transducer and activator of transcription 1, 91 kDa
204.00
91.39
0.207


471011
SF3B1
Splicing factor 3b, subunit 1, 155 kDa
171.22
65.74
0.276


471104
NOP5/NOP58
Nucleolar protein NOP5/NOP58
119.95
77.84
0.207


471207
NDUFS1
NADH dehydrogenase (ubiquinone) Fe—S protein 1, 75 kDa
152.75
64.26
0.207




(NADH-coenzyme Q reductase)





471441
PSMB2
Proteasome (prosome, macropain) subunit, beta type, 2
160.02
84.75
0.207


471461
ACSL3
Acyl-CoA synthetase long-chain family member 3
143.25
48.15
0.207


471593
CAB39
Calcium binding protein 39
125.47
90.94
0.276


471768
STK40
Serine/threonine kinase 40
150.57
81.43
0.310


471818
CAPRIN1
Cell cycle associated protein 1
233.39
93.24
0.069


471851
HDLBP
High density lipoprotein binding protein (vigilin)
770.41
90.63
0.034


471873
DTYMK
Deoxythymidylate kinase (thymidylate kinase)
151.55
81.98
0.276


471933
FKBP1A
FK506 binding protein 1A, 12 kDa
284.05
83.21
0.138


471975
C20orf116
Chromosome 20 open reading frame 116
168.09
95.60
0.379


472010
PRNP
Prion protein (p27-30) (Creutzfeld-Jakob disease, Gerstmann-
151.22
82.78
0.276




Strausler-Scheinker syndrome, fatal familial insomnia)





472024
C20orf30
Chromosome 20 open reading frame 30
180.50
82.62
0.138


472031
UBE2D3
Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
305.38
72.17
0.069


472038
UTP11L
UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
116.49
107.41
0.379


472056
SYNCRIP
Synaptotagmin binding, cytoplasmic RNA interacting protein
198.01
71.24
0.103


472119
MKKS
McKusick-Kaufman syndrome
110.70
82.99
0.276


472185
NDUFS5
NADH dehydrogenase (ubiquinone) Fe—S protein 5, 15 kDa
317.85
115.06
0.172




(NADH-coenzyme Q reductase)





472213
RRBP1
Ribosome binding protein 1 homolog 180 kDa (dog)
194.55
81.99
0.276


472330
C20orf3
Chromosome 20 open reading frame 3
210.62
71.28
0.345


472475
MACF1
Glycine-rich protein (GRP3S)
170.84
81.77
0.310


472535
AURKAIP1
Aurora kinase A interacting protein 1
236.28
92.32
0.345


472558
ERGIC3
ERGIC and golgi 3
273.22
82.09
0.138


472651
BLCAP
Bladder cancer associated protein
174.08
74.85
0.241


472737
TOP1
Topoisomerase (DNA) I
145.07
71.88
0.310


473296
TPD52L2
Tumor protein D52-like 2
198.42
74.39
0.172


473583
YBX1
Y box binding protein 1
706.53
98.38
0.034


473648
GART
Phosphoribosylglycinamide formyltransferase,
159.98
70.49
0.138




phosphoribosylglycinamide synthetase,







phosphoribosylaminoimidazole synthetase





473721
SLC2A1
Solute carrier family 2 (facilitated glucose transporter), member 1
496.75
142.19
0.345


473761
RTN3
Reticulon 3
222.45
76.58
0.103


473788
OTUB1
OTU domain, ubiquitin aldehyde binding 1
235.08
75.48
0.207


474005
SUMO3
SMT3 suppressor of mif two 3 homolog 3 (yeast)
224.13
104.97
0.138


474010
PTTG1IP
Pituitary tumor-transforming 1 interacting protein
472.39
85.43
0.138


474053
COL6A1
Collagen, type VI, alpha 1
240.21
60.68
0.345


474083
B4GALT2
UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 2
118.57
65.47
0.345


474213
UFD1L
Ubiquitin fusion degradation 1 like (yeast)
117.12
72.56
0.276


474584
AKR1A1
Aldo-keto reductase family 1, member A1 (aldehyde reductase)
216.03
70.29
0.138


474643
C22orf28
Chromosome 22 open reading frame 28
331.66
109.80
0.138


474751
MYH9
Myosin, heavy polypeptide 9, non-muscle
426.57
109.52
0.069


474833
CSNK1E
Casein kinase 1, epsilon
193.49
86.78
0.138


474914
RUTBC3
RUN and TBC1 domain containing 3
190.23
157.68
0.345


474938
SLC25A17
Solute carrier family 25 (mitochondrial carrier; peroxisomal
113.70
81.93
0.345




membrane protein, 34 kDa), member 17





474949
RBX1
Ring-box 1
145.55
82.29
0.241


474982
ACO2
Aconitase 2, mitochondrial
307.04
91.01
0.034


475125
ATXN10
Ataxin 10
198.54
95.44
0.172


475319
LRRFIP2
Leucine rich repeat (in FLII) interacting protein 2
104.35
72.12
0.310


475382
MTMR14
Myotubularin related protein 14
149.47
83.39
0.172


475392
TMEM111
Transmembrane protein 111
136.12
88.37
0.379


475663
RAB5A
RAB5A, member RAS oncogene family
119.70
91.27
0.241


475733
TOP2B
Topoisomerase (DNA) II beta 180 kDa
180.06
113.03
0.172


475812
STT3B
STT3, subunit of the oligosaccharyltransferase complex, homolog
108.24
76.02
0.310




B (S. cerevisiae)





476018
CTNNB1
Catenin (cadherin-associated protein), beta 1, 88 kDa
138.21
58.20
0.310


476033
TXNDC12
Thioredoxin domain containing 12 (endoplasmic reticulum)
146.57
70.89
0.172


476179
SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of
171.16
127.75
0.138




chromatin, subfamily c, member 1





476221
IHPK2
Inositol hexaphosphate kinase 2
145.26
55.31
0.241


476231
IMPDH2
IMP (inosine monophosphate) dehydrogenase 2
1006.91
110.38
0.034


476308
ALAS1
Aminolevulinate, delta-, synthase 1
132.82
82.50
0.345


476365
SCP2
Sterol carrier protein 2
690.56
180.11
0.276


476448
FLNB
Filamin B, beta (actin binding protein 278)
189.01
103.49
0.310


476706
MRPL37
Mitochondrial ribosomal protein L37
249.66
66.27
0.172


476930
CHMP2B
Chromatin modifying protein 2B
143.22
100.41
0.310


477157
DULLARD
Dullard homolog (Xenopus laevis)
158.37
96.36
0.103


477789
ATP1B3
ATPase, Na+/K+ transporting, beta 3 polypeptide
167.45
84.60
0.138


477892
GYG1
Glycogenin 1
151.92
63.62
0.345


478000
MBNL1
Muscleblind-like (Drosophila)
304.13
90.08
0.241


478044
PA2G4
Proliferation-associated 2G4, 38 kDa
460.10
87.56
0.103


478553
EIF4A2
Eukaryotic translation initiation factor 4A, isoform 2
403.21
91.85
0.069


479208
FBXL5
F-box and leucine-rich repeat protein 5
140.68
84.67
0.276


479264
LAP3
Leucine aminopeptidase 3
140.16
84.68
0.241


479634
SLC30A9
Solute carrier family 30 (zinc transporter), member 9
123.90
63.55
0.379


479693
SFRS11
Splicing factor, arginine/serine-rich 11
189.39
69.99
0.172


479728
GAPDH
Glyceraldehyde-3-phosphate dehydrogenase
7330.72
80.18
0.000


479747
BCAR1
Breast cancer anti-estrogen resistance 1
183.08
85.45
0.310


479814
POLR2B
Polymerase (RNA) II (DNA directed) polypeptide B, 140 kDa
170.30
62.57
0.310


480073
HNRPD
Heterogeneous nuclear ribonucleoprotein D (AU-rich element RN/
229.02
68.01
0.103




binding protein 1, 37 kDa)





480311
PDLIM5
PDZ and LIM domain 5
273.24
235.65
0.241


480465
SCYE1
Small inducible cytokine subfamily E, member 1 (endothelial
107.39
55.27
0.276




monocyte-activating)





480653
ANXA5
Annexin A5
303.60
104.16
0.069


481571
UQCRH
Similar to Ubiquinol-cytochrome C reductase complex 11 kDa
229.54
102.84
0.138




protein, mitochondrial precursor (Mitochondrial hinge protein)







(Cytochrome C1, nonheme 11 kDa protein) (Complex III subunit







VIII)





481720
MYO10
Myosin X
140.50
130.53
0.310


481898
CCBL2
Cysteine conjugate-beta lyase 2
134.41
54.32
0.310


482144
RPL26
Similar to 60S ribosomal protein L26
447.43
95.30
0.034


482363
SLC30A5
Solute carrier family 30 (zinc transporter), member 5
78.30
56.98
0.379


482526
TINP1
TGF beta-inducible nuclear protein 1
121.52
61.06
0.241


482868
KIAA0372
KIAA0372
126.07
60.99
0.241


483036
PJA2
Praja 2, RING-H2 motif containing
158.62
65.91
0.276


483067
C5orf13
Chromosome 5 open reading frame 13
318.12
190.12
0.379


483305
HINT1
Histidine triad nucleotide binding protein 1
236.40
118.42
0.207


483408
PPP2CA
Protein phosphatase 2 (formerly 2A), catalytic subunit, alpha
230.50
94.12
0.138




isoform





483454
CNN3
Calponin 3, acidic
211.93
89.89
0.207


483486
JMJD1B
Jumonji domain containing 1B
107.12
52.95
0.310


484138
FBXW11
F-box and WD-40 domain protein 11
117.64
68.50
0.379


484188
ATP6V0E1
ATPase, H+ transporting, lysosomal 9 kDa, V0 subunit e1
159.10
68.32
0.138


484242
UBXD8
UBX domain containing 8
125.98
75.93
0.207


484288
DDX41
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
214.13
74.98
0.138


484363
RNF130
Ring finger protein 130
97.65
67.32
0.138


484551
CPM
Carboxypeptidase M
186.28
78.16
0.310


484813
DEK
DEK oncogene (DNA binding)
260.77
83.22
0.172


485155
RPL35
Ribosomal protein L35
281.04
111.39
0.172


485195
SORT1
Sortilin 1
150.82
80.52
0.345


485246
PSMA5
Proteasome (prosome, macropain) subunit, alpha type, 5
164.31
83.49
0.207


485262
MTCH1
Mitochondrial carrier homolog 1 (C. elegans)
364.72
91.85
0.103


485365
AHCYL1
S-adenosylhomocysteine hydrolase-like 1
182.57
61.85
0.207


485616
DST
Dystonin
144.43
74.83
0.276


486542
BCLAF1
BCL2-associated transcription factor 1
184.76
58.42
0.207


487027
VIL2
Villin 2 (ezrin)
228.59
71.02
0.138


487054
TCP1
T-complex 1
209.76
78.62
0.138


487635
BZW2
Basic leucine zipper and W2 domains 2
250.31
146.18
0.172


487774
HNRPA2B1
Heterogeneous nuclear ribonucleoprotein A2/B1
218.53
87.55
0.103


488171
NUDCD3
NudC domain containing 3
607.73
183.50
0.034


488181
OGDH
Oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
245.90
110.90
0.207


488307
ECOP
EGFR-coamplified and overexpressed protein
151.47
75.46
0.345


488478
C7orf42
Chromosome 7 open reading frame 42
151.66
70.90
0.207


488671
BAZ1B
Bromodomain adjacent to zinc finger domain, 1B
114.54
65.20
0.207


489207
ASNS
Asparagine synthetase
262.06
124.38
0.172


489284
ARPC1B
Actin related protein 2/3 complex, subunit 1B, 41 kDa
555.08
109.32
0.103


489287
CPSF4
Cleavage and polyadenylation specific factor 4, 30 kDa
171.76
69.89
0.172


489336
SYAP1
Synapse associated protein 1, SAP47 homolog (Drosophila)
126.10
45.09
0.310


489615
PBEF1
Pro-B-cell colony enhancing factor 1
211.67
111.85
0.276


490203
CALD1
Caldesmon 1
242.44
103.25
0.207


490394
SSBP1
Single-stranded DNA binding protein 1
444.28
309.52
0.241


490415
ZYX
Zyxin
259.67
90.01
0.138


490745
DNAJB6
DnaJ (Hsp40) homolog, subfamily B, member 6
182.26
74.39
0.103


490795
FAM62B
Family with sequence similarity 62 (C2 domain containing)
256.81
139.32
0.276




member B





490874
MTX1
Metaxin 1
139.52
83.02
0.310


491336
ELP3
Elongation protein 3 homolog (S. cerevisiae)
98.38
59.66
0.379


491359
LMNA
Lamin A/C
797.11
108.53
0.138


491440
PPP2CB
Protein phosphatase 2 (formerly 2A), catalytic subunit, beta
146.90
77.42
0.276




isoform





491494
CCT3
Chaperonin containing TCP1, subunit 3 (gamma)
1152.31
109.73
0.034


491597
VDAC3
Voltage-dependent anion channel 3
189.10
60.03
0.207


491695
UBE2V2
Ubiquitin-conjugating enzyme E2 variant 2
1324.03
205.58
0.276


491745
TCEA1
Transcription elongation factor A (SII), 1
180.17
63.49
0.241


491988
TRAM1
Translocation associated membrane protein 1
151.74
62.44
0.172


492236
WDR42A
WD repeat domain 42A
135.63
62.96
0.310


492314
LAPTM4B
Lysosomal associated protein transmembrane 4 beta
315.85
98.92
0.138


492445
UBR5
Ubiquitin protein ligase E3 component n-recognin 5
133.59
70.25
0.345


492599
EIF3S3
Eukaryotic translation initiation factor 3, subunit 3 gamma, 40 kDa
457.44
91.86
0.069


492805
NMD3
NMD3 homolog (S. cerevisiae)
154.69
68.25
0.276


493362
AK3L1
Adenylate kinase 3
138.22
63.01
0.241


493750
WDR40A
WD repeat domain 40A
158.95
64.13
0.345


494173
ANXA1
Annexin A1
663.71
206.40
0.138


494419
LAMP1
Lysosomal-associated membrane protein 1
278.30
123.84
0.276


494457
NINJ1
Ninjurin 1
146.99
120.17
0.379


494604
ANP32B
Acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
297.30
74.71
0.069


494614
BAT2D1
BAT2 domain containing 1
103.03
72.44
0.310


494691
PFN1
Profilin 1
582.68
96.95
0.069


494700
SLC44A1
Solute carrier family 44, member 1
156.34
79.78
0.379


494985
FBXW2
F-box and WD-40 domain protein 2
97.45
68.65
0.379


495039
NDUFA8
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19
100.91
70.67
0.345


495349
KIAA0515
KIAA0515
213.73
62.92
0.069


495471
PMPCA
Peptidase (mitochondrial processing) alpha
174.09
84.07
0.172


495605
CD99
CD99 antigen
171.31
62.16
0.138


495851
APOO
Apolipoprotein O
144.33
80.53
0.345


495960
ATP6AP2
ATPase, H+ transporting, lysosomal accessory protein 2
177.66
91.25
0.276


496068
PCTK1
PCTAIRE protein kinase 1
177.60
80.15
0.207


496098
OTUD5
OTU domain containing 5
171.08
119.61
0.207


496271
?
Full-length cDNA clone CS0DJ002YF04 of T cells (Jurkat cell line)
552.58
198.74
0.172




Cot 10-normalized of Homo sapiens (human)





496487
ATF4
Activating transcription factor 4 (tax-responsive enhancer element
644.83
92.22
0.069




B67)





496646
IL13RA1
Interleukin 13 receptor, alpha 1
117.23
77.35
0.310


496684
LAMP2
Lysosomal-associated membrane protein 2
175.62
85.98
0.241


497183
IVNS1ABP
Influenza virus NS1A binding protein
156.30
56.55
0.241


497599
WARS
Tryptophanyl-tRNA synthetase
328.30
141.43
0.103


497692
NSL1
NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)
142.41
132.49
0.379


497893
ENAH
Enabled homolog (Drosophila)
133.62
90.22
0.276


498239
FH
Fumarate hydratase
304.63
108.28
0.276


498313
ADSS
Adenylosuccinate synthase
138.41
96.89
0.276


498317
C1orf121
Chromosome 1 open reading frame 121
139.90
108.25
0.379


498455
LARP5
La ribonucleoprotein domain family, member 5
142.32
72.97
0.241


498548
RBM17
RNA binding motif protein 17
119.60
106.34
0.207


498727
DHCR24
24-dehydrocholesterol reductase
380.21
178.18
0.207


499145
YME1L1
YME1-like 1 (S. cerevisiae)
218.20
87.96
0.241


499158
GGA1
Golgi associated, gamma adaptin ear containing, ARF binding
149.92
94.46
0.276




protein 1





499594
TIMM23
Translocase of inner mitochondrial membrane 23 homolog (yeast)
116.05
77.66
0.241


499833
REEP3
Receptor accessory protein 3
97.26
86.49
0.345


499891
HNRPH3
Heterogeneous nuclear ribonucleoprotein H3 (2H9)
152.75
70.91
0.103


499925
VPS26A
Vacuolar protein sorting 26 homolog A (S. pombe)
129.39
63.83
0.172


499960
SAR1A
SAR1 gene homolog A (S. cerevisiae)
122.18
69.10
0.172


500067
PPP3CB
Protein phosphatase 3 (formerly 2B), catalytic subunit, beta
120.27
66.72
0.241




isoform (calcineurin A beta)





500101
VCL
Vinculin
197.78
102.19
0.207


500375
ENTPD6
Ectonucleoside triphosphate diphosphohydrolase 6 (putative
163.42
84.78
0.276




function)





500409
GLUD1
Glutamate dehydrogenase 1
161.37
95.54
0.138


500546
IDE
Insulin-degrading enzyme
112.83
68.82
0.310


500674
TM9SF3
Transmembrane 9 superfamily member 3
215.50
58.43
0.207


500775
ZNF207
Zinc finger protein 207
233.29
62.27
0.034


500842
MGEA5
Meningioma expressed antigen 5 (hyaluronidase)
179.67
93.93
0.310


500874
CUEDC2
CUE domain containing 2
129.96
52.06
0.310


501012
ADD3
Adducin 3 (gamma)
223.70
119.75
0.310


501023
MXI1
MAX interactor 1
94.44
62.74
0.345


501203
TIAL1
TIA1 cytotoxic granule-associated RNA binding protein-like 1
146.01
73.16
0.276


501293
BSG
Basigin (OK blood group)
737.88
112.29
0.103


501309
CIRBP
Cold inducible RNA binding protein
265.44
117.90
0.034


501353
PLEKHJ1
Pleckstrin homology domain containing, family J member 1
100.87
56.61
0.379


501376
UROS
Uroporphyrinogen III synthase (congenital erythropoietic porphyria)
130.07
71.33
0.241


501420
NCLN
Nicalin homolog (zebrafish)
177.01
86.48
0.241


501629
IER2
Immediate early response 2
140.79
60.99
0.241


501684
NAP1L4
Nucleosome assembly protein 1-like 4
166.93
111.13
0.138


501735
STIM1
Stromal interaction molecule 1
117.62
71.87
0.276


501853
TMEM9B
TMEM9 domain family, member B
110.79
91.41
0.379


501924
USP47
Ubiquitin specific peptidase 47
132.14
118.32
0.345


501991
MLSTD2
Male sterility domain containing 2
96.74
62.95
0.379


502302
CAT
Catalase
158.19
107.96
0.345


502328
CD44
CD44 antigen (homing function and Indian blood group system)
366.11
100.63
0.172


502461
DGKZ
Diacylglycerol kinase, zeta 104 kDa
109.99
96.64
0.310


502528
NDUFS3
NADH dehydrogenase (ubiquinone) Fe—S protein 3, 30 kDa
119.28
75.88
0.207




(NADH-coenzyme Q reductase)





502630
C11orf31
Chromosome 11 open reading frame 31
170.27
98.83
0.276


502659
RHOC
Ras homolog gene family, member C
253.62
101.47
0.138


502705
PRPF19
PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
198.31
100.04
0.276


502745
FADS2
Fatty acid desaturase 2
266.18
116.45
0.276


502769
SLC3A2
Solute carrier family 3 (activators of dibasic and neutral amino acid
276.24
84.47
0.138




transport), member 2





502773
ADI1
Acireductone dioxygenase 1
159.84
55.74
0.103


502823
PRDX5
Peroxiredoxin 5
183.65
76.11
0.241


502829
SF1
Splicing factor 1
263.86
66.20
0.069


502836
ARL2
ADP-ribosylation factor-like 2
134.06
114.72
0.310


502842
CAPN1
Calpain 1, (mu/I) large subunit
287.11
101.89
0.207


502872
MAP3K11
Mitogen-activated protein kinase kinase kinase 11
128.70
82.13
0.276


502876
RHOB
Ras homolog gene family, member B
165.00
92.57
0.310


503093
ZFP36L2
Zinc finger protein 36, C3H type-like 2
150.79
67.83
0.207


503222
RAB6A
RAB6A, member RAS oncogene family
152.69
73.96
0.241


503251
PPME1
Protein phosphatase methylesterase 1
123.71
52.56
0.207


503597
HSPC148
Hypothetical protein HSPC148
107.89
76.02
0.276


503709
TMEM123
Transmembrane protein 123
339.10
161.64
0.172


503716
DCUN1D5
DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)
167.32
87.13
0.138


503787
DARS
Aspartyl-tRNA synthetase
147.34
55.17
0.138


504237
STT3A
STT3, subunit of the oligosaccharyltransferase complex, homolog
117.19
108.95
0.345




A (S. cerevisiae)





504517
RPS27
Tetraspanin 9
176.40
121.62
0.379


504613
PTMS
Parathymosin
175.13
81.37
0.345


504620
PHB2
Prohibitin 2
506.51
79.86
0.069


504687
MYL9
Elongation factor Tu family protein
343.66
100.94
0.379


504828
DDX47
DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
130.63
59.08
0.379


504895
STRAP
Serine/threonine kinase receptor associated protein
221.43
95.09
0.138


505033
KRAS
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
115.82
83.04
0.310


505059
PSMD4
Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
259.00
62.63
0.103


505625
C12orf10
Chromosome 12 open reading frame 10
105.33
77.88
0.345


505652
COPZ1
Coatomer protein complex, subunit zeta 1
204.89
87.20
0.000


505676
CIP29
Cytokine induced protein 29 kDa
184.81
88.39
0.241


505705
MYL6
Myosin, light polypeptide 6, alkali, smooth muscle and non-muscle
438.52
109.87
0.069


505806
PBXIP1
Pre-B-cell leukemia transcription factor interacting protein 1
115.75
83.63
0.310


505824
SAMM50
Sorting and assembly machinery component 50 homolog (S. cerevisiae)
242.60
117.59
0.172


506215
RARS
Arginyl-tRNA synthetase
192.15
85.96
0.172


506325
NUDT4
Nudix (nucleoside diphosphate linked moiety X)-type motif 4
121.40
87.04
0.379




pseudogene 2





506759
ATP2A2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
375.19
241.76
0.241


506861
DDX54
DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
199.70
104.77
0.241


507074
KIAA0152
KIAA0152
244.90
89.86
0.069


507162
VPS37B
Vacuolar protein sorting 37 homolog B (S. cerevisiae)
142.45
79.66
0.276


507584
POLR1D
Polymerase (RNA) I polypeptide D, 16 kDa
121.94
73.07
0.241


507680
PFAAP5
Phosphonoformate immuno-associated protein 5
143.30
68.40
0.345


507910
PGRMC2
Progesterone receptor membrane component 2
131.09
75.85
0.207


507916
TSC22D1
TSC22 domain family, member 1
344.52
102.84
0.172


508010
FNDC3A
Fibronectin type III domain containing 3A
264.21
157.30
0.241


508644
FLJ10154
Hypothetical protein FLJ10154
183.99
75.88
0.310


509163
ERGIC1
Endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
147.54
71.85
0.103


509226
FKBP3
FK506 binding protein 3, 25 kDa
146.28
97.77
0.241


509264
KLHDC2
Kelch domain containing 2
117.21
72.23
0.207


509414
KTN1
Kinectin 1 (kinesin receptor)
196.92
103.65
0.207


509622
RGL2
Ral guanine nucleotide dissociation stimulator-like 2
136.36
70.20
0.345


509736
HSP90AB1
Heat shock protein 90 kDa alpha (cytosolic), class B member 1
2045.82
87.83
0.000


509791
ERH
Enhancer of rudimentary homolog (Drosophila)
148.95
80.20
0.207


509909
NUMB
Numb homolog (Drosophila)
115.97
62.99
0.241


510087
ENSA
Endosulfine alpha
196.15
70.81
0.034


510328
DDX24
DEAD (Asp-Glu-Ala-Asp) box polypeptide 24
446.38
126.73
0.103


510402
CD46
CD46 molecule, complement regulatory protein
255.43
87.89
0.276


511067
FAM82C
Family with sequence similarity 82, member C
193.94
125.16
0.345


511138
TMEM87A
Transmembrane protein 87A
153.90
71.25
0.241


511149
SNAP23
Synaptosomal-associated protein, 23 kDa
159.76
70.15
0.276


511425
SRP9
Signal recognition particle 9 kDa
1439.84
206.14
0.069


511504
TCF12
Transcription factor 12 (HTF4, helix-loop-helix transcription factors
175.22
83.75
0.276




4)





511862

Similar to 60S acidic ribosomal protein P1
182.40
88.27
0.379


511952
CBX6
Chromobox homolog 6
153.88
81.20
0.276


512005
ARPC3
Actin related protein 2/3 complex, subunit 3, 21 kDa
175.09
73.61
0.241


512465
SURF4
Surfeit 4
272.49
79.31
0.069


512525
RPS17
Ribosomal protein S17
1561.21
128.47
0.069


512607
MIR16
Membrane interacting protein of RGS16
243.63
112.71
0.207


512640
PRKCSH
Protein kinase C substrate 80K-H
369.95
87.75
0.172


512661
ISY1
ISY1 splicing factor homolog (S. cerevisiae)
247.17
110.21
0.241


512676
RPS25
Ribosomal protein S25
200.49
132.68
0.241


512693
METT11D1
Methyltransferase 11 domain containing 1
119.37
86.98
0.345


512756
THAP7
THAP domain containing 7
139.40
88.58
0.345


512815
AP3D1
Adaptor-related protein complex 3, delta 1 subunit
260.40
98.20
0.034


512857
CD151
CD151 antigen
289.17
93.65
0.207


512867
CASC4
Cancer susceptibility candidate 4
130.94
70.38
0.207


512908
ARPP-19
Cyclic AMP phosphoprotein, 19 kD
226.51
76.75
0.207


513043
IMP3
IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
135.64
58.16
0.310


513055
WDR61
WD repeat domain 61
114.60
53.12
0.345


513057
RANBP5
RAN binding protein 5
280.02
118.69
0.172


513058
TMED3
Transmembrane emp24 protein transport domain containing 3
180.01
81.33
0.138


513071
MESDC1
Mesoderm development candidate 1
153.38
113.49
0.276


513083
RPL9
Ribosomal protein L9
1564.85
164.78
0.034


513141
IDH2
Isocitrate dehydrogenase 2 (NADP+), mitochondrial
276.13
73.73
0.103


513145
NGRN
Neugrin, neurite outgrowth associated
292.66
85.21
0.034


513153
FURIN
Furin (paired basic amino acid cleaving enzyme)
171.95
95.68
0.379


513230
MRPL28
Mitochondrial ribosomal protein L28
206.58
141.00
0.241


513242
RHOT2
Ras homolog gene family, member T2
146.56
66.79
0.345


513261
HN1L
Hematological and neurological expressed 1-like
169.07
73.84
0.138


513266
NDUFB10
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22
141.77
93.82
0.345


513470
NFATC2IP
Nuclear factor of activated T-cells, cytoplasmic, calcineurin-
123.18
55.34
0.310




dependent 2 interacting protein





513488
MVP
Major vault protein
276.00
95.97
0.276


513490
ALDOA
Aldolase A, fructose-bisphosphate
1575.38
81.23
0.034


513520
BCKDK
Branched chain ketoacid dehydrogenase kinase
181.01
99.21
0.276


513522
FUS
Fusion (involved in t(12; 16) in malignant liposarcoma)
402.21
88.89
0.034


513631
ARL2BP
ADP-ribosylation factor-like 2 binding protein
133.32
76.06
0.379


513856
DPH1
DPH1 homolog (S. cerevisiae)
153.80
77.15
0.172


513984
FLII
Flightless 1 homolog (Drosophila)
218.66
80.64
0.103


514012
MAP2K3
Mitogen-activated protein kinase kinase 3
206.91
198.73
0.379


514036
SDF2
Stromal cell-derived factor 2
139.48
83.16
0.379


514038
FLOT2
Flotillin 2
205.94
75.37
0.241


514174
JUP
Junction plakoglobin
311.95
175.04
0.310


514196
RPL27
Ribosomal protein L27
445.53
163.18
0.103


514211
TMEM101
Transmembrane protein 101
207.70
66.43
0.345


514216
SLC25A39
Solute carrier family 25, member 39
372.09
78.71
0.103


514220
GRN
Granulin
569.94
118.75
0.103


514297
UBE2Z
Ubiquitin-conjugating enzyme E2Z (putative)
149.22
70.83
0.172


514303
PHB
Prohibitin
337.86
78.21
0.103


514435
SF3B3
Splicing factor 3b, subunit 3, 130 kDa
245.52
67.98
0.138


514489
WBP2
WW domain binding protein 2
367.18
97.07
0.138


514535
LGALS3BP
Lectin, galactoside-binding, soluble, 3 binding protein
714.12
134.59
0.172


514581
ACTG1
Actin, gamma 1
6790.08
96.54
0.000


514590
HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate
234.48
89.80
0.241


514819
AP2B1
Adaptor-related protein complex 2, bela 1 subunit
184.47
53.67
0.207


514870
ATP5F1
ATP synthase, H+ transporting, mitochondrial F0 complex, subuni
441.56
130.47
0.034




b, isoform 1





514920
CALCOCO
Calcium binding and coiled-coil domain 2
151.26
76.62
0.241


514934
CAPZA1
Capping protein (actin filament) muscle Z-line, alpha 1
232.49
84.07
0.276


515003
C19orf6
Chromosome 19 open reading frame 6
218.92
96.61
0.172


515005
STK11
Serine/threonine kinase 11 (Peutz-Jeghers syndrome)
127.27
85.12
0.379


515018
GNA13
Guanine nucleotide binding protein (G protein), alpha 13
162.22
105.65
0.345


515053
AES
Amino-terminal enhancer of split
314.90
95.73
0.138


515070
EEF2
Eukaryotic translation elongation factor 2
403.41
101.00
0.034


515092
CLPP
ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit
173.03
103.29
0.241




homolog (E. coli)





515155
C19orf43
Chromosome 19 open reading frame 43
161.94
77.42
0.138


515162
CALR
Calreticulin
575.58
88.03
0.034


515164
GADD45GIP1
Growth arrest and DNA-damage-inducible, gamma interacting
191.12
69.42
0.276




protein 1





515210
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
233.68
80.33
0.207


515255
LSM4
LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
266.66
105.98
0.276


515266
UPF1
UPF1 regulator of nonsense transcripts homolog (yeast)
163.88
99.99
0.276


515271
SFRS14
Splicing factor, arginine/serine-rich 14
124.30
81.86
0.310


515329
RPL22
Ribosomal protein L22
191.43
75.49
0.138


515371
CAPNS1
Calpain, small subunit 1
404.46
95.10
0.069


515406
AKT2
V-akt murine thymoma viral oncogene homolog 2
139.00
124.72
0.345


515417
EGLN2
Egl nine homolog 2 (C. elegans)
257.04
138.23
0.379


515432
DEDD2
Death effector domain containing 2
94.65
52.25
0.379


515472
SNRPD2
Small nuclear ribonucleoprotein D2 polypeptide 16.5 kDa
292.31
154.43
0.207


515475
SYMPK
Symplekin
133.18
53.29
0.241


515487
CALM3
Calmodulin 3 (phosphorylase kinase, delta)
439.26
95.22
0.069


515494
SLC1A5
Solute carrier family 1 (neutral amino acid transporter), member 5
448.32
106.79
0.138


515500
SAE1
SUMO-1 activating enzyme subunit 1
380.21
79.67
0.034


515515
KDELR1
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention
261.62
81.81
0.138




receptor 1





515517
RPL18
Ribosomal protein L18
743.38
74.48
0.103


515524
NUCB1
Nucleobindin 1
350.34
117.21
0.103


515540
PTOV1
Prostate tumor overexpressed gene 1
175.30
98.47
0.172


515550
LOC284361
Hematopoietic signal peptide-containing
135.48
82.61
0.310


515598
PRPF31
PRP31 pre-mRNA processing factor 31 homolog (yeast)
368.40
151.24
0.276


515607
PPP1R12C
Protein phosphatase 1, regulatory (inhibitor) subunit 12C
165.22
97.14
0.379


515642
GPSN2
Glycoprotein, synaptic 2
171.37
74.21
0.345


515785
BLVRB
Biliverdin reductase B (flavin reductase (NADPH))
143.92
94.30
0.310


515846
RUVBL2
RuvB-like 2 (E. coli)
354.78
98.40
0.138


515848
HADHB
Hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme
213.42
90.90
0.103




thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta







subunit





515890
YPEL5
Yippee-like 5 (Drosophila)
181.92
82.16
0.276


516075
TIA1
TIA1 cytotoxic granule-associated RNA binding protein
183.23
80.58
0.310


516077
FLJ14668
Hypothetical protein FLJ14668
112.96
75.82
0.276


516087
TEX261
Testis expressed sequence 261
146.81
110.15
0.241


516111
DCTN1
Dynactin 1 (p150, glued homolog, Drosophila)
261.96
94.41
0.103


516114
WBP1
WW domain binding protein 1
114.03
56.61
0.310


516157
MAT2A
Methionine adenosyltransferase II, alpha
195.52
68.87
0.172


516450
SMPD4
Sphingomyelin phosphodiesterase 4, neutral membrane (neutral
248.30
97.54
0.172




sphingomyelinase-3)





516522
INTS3
Integrator complex subunit 3
142.16
102.91
0.379


516539
HNRPA3
Heterogeneous nuclear ribonucleoprotein A3
223.52
72.69
0.138


516587
UBE2Q1
Ubiquitin-conjugating enzyme E2Q (putative) 1
131.58
55.37
0.345


516533
NCKAP1
NCK-associated protein 1
198.42
62.97
0.241


516711
CHPF
Chondroitin polymerizing factor
213.73
142.81
0.379


516790
ARHGEF2
Rho/rac guanine nucleotide exchange factor (GEF) 2
133.62
84.47
0.379


516807
STK25
Serine/threonine kinase 25 (STE20 homolog, yeast)
455.41
109.35
0.138


516826
TRIB3
Tribbles homolog 3 (Drosophila)
228.24
99.31
0.241


516855
CENPB
Centromere protein B, 80 kDa
202.67
80.52
0.276


517080
SLC35C2
Solute carrier family 35, member C2
163.93
94.82
0.207


517106
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
178.82
93.37
0.345


517134
C20orf43
Chromosome 20 open reading frame 43
247.39
69.92
0.069


517145
ENO1
Enolase 1, (alpha)
3401.32
102.15
0.000


517168
TAGLN2
Transgelin 2
626.02
75.92
0.069


517216
PEA15
Phosphoprotein enriched in astrocytes 15
283.17
82.20
0.172


517232
PEX19
Peroxisomal biogenesis factor 19
151.27
57.99
0.207


517240
IFNGR2
Interferon gamma receptor 2 (interferon gamma transducer 1)
158.55
79.26
0.172


517262
SON
SON DNA binding protein
197.08
79.92
0.138


517293
F11R
F11 receptor
215.86
109.54
0.276


517338
ATP6V1E1
ATPase, H+ transporting, lysosomal 31 kDa, V1 subunit E isoform 1
197.20
81.17
0.069


517342
DEDD
Death effector domain containing
136.31
62.93
0.276


517356
COL18A1
Collagen, type XVIII, alpha 1
388.40
175.92
0.345


517357
DGCR2
DiGeorge syndrome critical region gene 2
214.17
92.03
0.241


517421
PCQAP
PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-
205.74
178.98
0.241




associated protein





517438
ASCC2
Activating signal cointegrator 1 complex subunit 2
138.59
89.52
0.138


517517
EP300
E1A binding protein p300
124.61
92.25
0.379


517543
PES1
Pescadillo homolog 1, containing BRCT domain (zebrafish)
242.64
124.33
0.276


517582
MCM5
MCM5 minichromosome maintenance deficient 5, cell division
424.00
105.24
0.172




cycle 46 (S. cerevisiae)





517622
UNC84B
Unc-84 homolog B (C. elegans)
131.34
80.16
0.310


517641
L3MBTL2
L(3)mbt-like 2 (Drosophila)
116.46
67.43
0.345


517666
CYB5R3
Cytochrome b5 reductase 3
314.58
161.98
0.138


517731
TRABD
TraB domain containing
180.88
102.41
0.276


517768
BRP44
Brain protein 44
127.10
104.51
0.345


517792
C3orf10
Chromosome 3 open reading frame 10
175.04
80.24
0.069


517817
TMEM43
Transmembrane protein 43
136.66
75.36
0.310


517821

CDNA clone IMAGE: 5278517
120.53
66.29
0.310


517888
CRTAP
Cartilage associated protein
208.15
77.38
0.207


517948
DHX30
DEAH (Asp-Glu-Ala-His) box polypeptide 30
209.13
121.04
0.207


517949
MAP4
Microtubule-associated protein 4
306.69
79.18
0.103


517969
APEH
N-acylaminoacyl-peptide hydrolase
330.37
60.97
0.207


517981
TUSC2
Tumor suppressor candidate 2
129.92
69.61
0.310


518060
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
303.59
116.09
0.207


518123
TFG
TRK-fused gene
189.81
59.70
0.138


518236
SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
272.42
82.37
0.138


518244
RPN1
Ribophorin I
232.54
86.03
0.172


518249
CNBP
CCHC-type zinc finger, nucleic acid binding protein
307.66
69.72
0.034


518250
COPG
Coatomer protein complex, subunit gamma
205.51
104.21
0.276


518265
CDV3
CDV3 homolog (mouse)
192.56
91.81
0.138


518326
SERP1
Stress-associated endoplasmic reticulum protein 1
233.71
64.27
0.069


518346
SSR3
Signal sequence receptor, gamma (translocon-associated protein
133.69
62.65
0.241




gamma)





518374
QSOX1
Quiescin Q6 sulfhydryl oxidase 1
151.71
84.80
0.310


518424
NDUFB5
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16 kDa
625.19
180.45
0.276


518460
AP2M1
Adaptor-related protein complex 2, mu 1 subunit
584.10
76.35
0.069


518464
PSMD2
Proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
538.23
93.02
0.103


518525
GLUL
Glutamate-ammonia ligase (glutamine synthetase)
326.37
86.68
0.138


518551
RPL31
Ribosomal protein L31
883.50
204.46
0.103


518608
MRFAP1L1
Morf4 family associated protein 1-like 1
107.24
53.27
0.172


518609
ARPC5
Actin related protein 2/3 complex, subunit 5, 16 kDa
226.65
65.59
0.172


518750
OCIAD1
OCIA domain containing 1
121.73
78.62
0.172


518805
HMGA1
High mobility group AT-hook 1
1583.57
131.69
0.172


518827
CCNI
Cyclin I
495.99
157.57
0.034


519276
MAPKAPK2
Mitogen-activated protein kinase-activated protein kinase 2
172.89
87.16
0.172


519304
PELO
Pelota homolog (Drosophila)
204.10
151.63
0.310


519346
ERBB2IP
Erbb2 interacting protein
171.05
83.90
0.241


519347
SFRS12
Splicing factor, arginine/serine-rich 12
99.98
49.97
0.310


519520
RPS25
Ribosomal protein S25
717.45
181.09
0.034


519523
SERPINB6
Serpin peptidase inhibitor, clade B (ovalbumin), member 6
180.64
74.06
0.172


519557
TMEM14C
Transmembrane protein 14C
139.62
70.39
0.276


519718
TTC1
Tetratricopeptide repeat domain 1
119.41
63.74
0.276


519756
STK10
Serine/threonine kinase 10
131.85
89.36
0.379


519818
MGAT1
Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-
179.60
85.97
0.138




acetylglucosaminyltransferase





519909
MARCKS
Myristoylated alanine-rich protein kinase C substrate
360.12
219.46
0.310


519930
C6orf62
Chromosome 6 open reading frame 62
131.39
63.83
0.138


520026
VARS2
Valyl-tRNA synthetase
317.40
77.78
0.241


520028
HSPA1A
Heat shock 70 kDa protein 1A
267.63
174.20
0.241


520037
NEU1
Sialidase 1 (lysosomal sialidase)
229.35
119.62
0.310


520070
CUTA
CUtA divalent cation tolerance homolog (E. coli)
154.48
68.26
0.207


520140
SRF
Serum response factor (c-fos serum response element-binding
130.75
59.73
0.379




transcription factor)





520189
ELOVL5
ELOVL family member 5, elongation of long chain fatty acids
137.81
70.07
0.276




(FEN1/Elo2, SUR4/Elo3-like, yeast)





520205
EIF2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1
238.20
66.39
0.138


520210
KDELR2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention
225.97
94.83
0.138




receptor 2





520287
C6orf111
Chromosome 6 open reading frame 111
170.77
69.67
0.207


520313
CD164
CD164 antigen, sialomucin
387.43
78.65
0.172


520383
STX7
Syntaxin 7
200.61
198.70
0.379


520421
PERP
PERP, TP53 apoptosis effector
278.10
105.31
0.379


520459
GTF2I
General transcription factor II, i
179.36
111.40
0.345


520623
C7orf27
Chromosome 7 open reading frame 27
107.46
71.73
0.345


520640
ACTB
Actin, beta
4381.34
95.98
0.034


520740
SCRN1
Secernin 1
162.41
76.80
0.276


520794
YKT6
SNARE protein Ykt6
322.61
99.65
0.276


520898
CTSB
Cathepsin B
555.78
100.98
0.034


520943
EIF4H
Eukaryotic translation initiation factor 4H
520.03
71.02
0.069


520967
MDH2
Malate dehydrogenase 2, NAD (mitochondrial)
368.83
66.26
0.069


520973
HSPB1
Heat shock 27 kDa protein 1
608.95
126.99
0.138


520974
YWHAG
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
171.99
87.92
0.310




activation protein, gamma polypeptide





521064
ZNF655
Zinc finger protein 655
100.31
68.90
0.379


521151
ZNF672
Zinc finger protein 672
185.36
113.36
0.310


521289
REPIN1
Replication initiator 1
220.03
101.31
0.172


521487
TMEM66
Transmembrane protein 66
276.62
74.21
0.138


521640
RAD23B
RAD23 homolog B (S. cerevisiae)
334.78
294.31
0.241


521809
RP13-
Cofactor of BRCA1
180.78
84.61
0.172



122B23.3






521903
LY6E
Lymphocyte antigen 6 complex, locus E
425.61
138.70
0.172


521924
SIAHBP1
Fuse-binding protein-interacting repressor
381.93
82.10
0.103


521969
NDUFB11
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3 kDa
144.58
114.75
0.379


521973
WDR13
WD repeat domain 13
177.47
106.14
0.172


522074
TSC22D3
TSC22 domain family, member 3
194.81
93.94
0.207


522110
CREB3
CAMP responsive element binding protein 3
153.05
94.31
0.241


522114
CLTA
Clathrin, light polypeptide (Lca)
317.85
88.44
0.103


522310
NANS
N-acetylneuraminic acid synthase (sialic acid synthase)
114.60
62.52
0.310


522373
GSN
Gelsolin (amyloidosis, Finnish type)
434.41
204.85
0.138


522394
HSPA5
Heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa)
367.53
102.24
0.172


522463
EEF1A1
Eukaryotic translation elongation factor 1 alpha 1
9324.87
148.86
0.000


522507
FBXW5
F-box and WD-40 domain protein 5
199.15
90.48
0.276


522584
TMSB4X
Thymosin, beta 4, X-linked
1362.45
161.68
0.172


522590
EIF1AX
Eukaryotic translation initiation factor 1A, X-linked
136.35
67.99
0.207


522632
TIMP1
TIMP metallopeptidase inhibitor 1
386.91
180.87
0.241


522665
MAGED2
Melanoma antigen family D, 2
430.71
110.49
0.138


522675
LAS1L
LAS1-like (S. cerevisiae)
201.59
69.13
0.241


522752
PSMD10
Proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
122.91
60.90
0.276


522817
BCAP31
B-cell receptor-associated protein 31
290.93
84.50
0.172


522819
IRAK1
Interleukin-1 receptor-associated kinase 1
382.94
97.80
0.138


522823
EMD
Emerin (Emery-Dreifuss muscular dystrophy)
171.35
87.58
0.379


522932
NCOA4
Nuclear receptor coactivator 4
209.19
70.05
0.138


522995
EIF4EBP2
Eukaryotic translation initiation factor 4E binding protein 2
176.81
73.83
0.103


523004
PSAP
Prosaposin (variant Gaucher disease and variant metachromatic
1098.27
123.65
0.034




leukodystrophy)





523012
DDIT4
DNA-damage-inducible transcript 4
415.15
125.10
0.276


523054
TMEM50A
Transmembrane protein 50A
139.64
109.41
0.276


523131
TRAPPC3
Trafficking protein particle complex 3
139.68
66.61
0.310


523145
DDOST
Dolichyl-diphosphooligosaccharide-protein glycosyltransferase
338.02
90.17
0.103


523215
NDUFB8
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19 kDa
199.51
106.37
0.172


523238
NOLC1
Nucleolar and coiled-body phosphoprotein 1
176.02
83.34
0.138


523262
TMEM59
Transmembrane protein 59
262.49
95.63
0.069


523299
EIF3S10
Eukaryotic translation initiation factor 3, subunit 10 theta, 150/170 kDa
180.25
76.56
0.172


523302
PRDX3
Peroxiredoxin 3
948.84
182.31
0.138


523560
HSP90AA2
Heat shock protein 90 kDa alpha (cytosolic), class A member 2
971.87
81.16
0.000


523680
SSRP1
Structure specific recognition protein 1
259.94
67.23
0.138


523789
TncRNA
Trophoblast-derived noncoding RNA
290.76
109.38
0.310


523829
POLD4
Polymerase (DNA-directed), delta 4
192.79
92.64
0.310


523836
GSTP1
Glutathione S-transferase pi
363.83
79.45
0.103


523852
CCND1
Cyclin D1
257.94
79.21
0.310


523875
INPPL1
Inositol polyphosphate phosphatase-like 1
198.48
82.78
0.310


524009
AASDHPPT
Aminoadipate-semialdehyde dehydrogenase-phosphopantetheiny
139.83
74.10
0.345




transferase





524081
DPAGT1
Dolichyl-phosphate (UDP-N-acetylglucosamine) N-
125.85
78.99
0.345




acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase





524084
RNF26
Ring finger protein 26
170.50
95.60
0.310


524161
RSU1
Ras suppressor protein 1
173.91
80.13
0.276


524171
RAD52
RAD52 homolog (S. cerevisiae)
128.36
73.88
0.345


524183
FKBP4
FK506 binding protein 4, 59 kDa
345.04
165.12
0.138


524195
ARHGAP2
Rho GTPase activating protein 21
118.87
87.10
0.379


524214
MLF2
Myeloid leukemia factor 2
271.91
68.75
0.138


524219
TPI1
Triosephosphate isomerase 1
1085.58
88.77
0.069


524271
PHC2
Polyhomeotic-like 2 (Drosophila)
333.79
105.07
0.138


524367
CBARA1
Calcium binding atopy-related autoantigen 1
133.75
65.29
0.207


524395
TUBA1A
Tubulin, alpha 1a
423.08
127.26
0.241


524464
ATP5G2
ATP synthase, H+ transporting, mitochondrial F0 complex, subuni
300.01
124.98
0.172




c (subunit 9), isoform 2





524502
RNF41
Ring finger protein 41
110.38
68.59
0.241


524530
CTDSP2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A
286.91
136.97
0.103




small phosphatase 2





524590
RAB21
RAB21, member RAS oncogene family
112.13
48.40
0.379


524599
NAP1L1
60S ribosomal protein L6 (RPL6A)
559.97
99.14
0.034


524690
PPIE
Peptidylprolyl isomerase E (cyclophilin E)
224.33
109.34
0.207


524788
RAB35
RAB35, member RAS oncogene family
97.18
65.96
0.379


524809
CLIP1
CAP-GLY domain containing linker protein 1
121.91
90.76
0.345


524899
SAP18
Sin3-associated polypeptide, 18 kDa
129.03
72.41
0.172


524920
ZFP91
Zinc finger protein 91 homolog (mouse)
128.10
83.51
0.207


524969
UFM1
Ubiquitin-fold modifier 1
172.41
84.47
0.310


525134
POMGNT1
Protein O-linked mannose beta1,2-N-
161.82
102.74
0.345




acetylglucosaminyltransferase





525163
ANKRD10
Ankyrin repeat domain 10
156.22
79.59
0.207


525232
LRP10
Low density lipoprotein receptor-related protein 10
201.98
129.16
0.138


525238
C14orf119
Chromosome 14 open reading frame 119
141.96
104.26
0.276


525330
ARF6
ADP-ribosylation factor 6
191.66
134.63
0.103


525391
C1orf123
Chromosome 1 open reading frame 123
98.24
87.20
0.310


525527
RER1
RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)
137.56
72.32
0.310


525626
PACS2
Phosphofurin acidic cluster sorting protein 2
126.74
98.42
0.345


525899
C6orf49
Chromosome 6 open reading frame 49
144.67
83.87
0.172


526464
PML
Promyelocytic leukemia
129.51
84.95
0.345


526521
MDH1
Malate dehydrogenase 1, NAD (soluble)
414.98
150.61
0.103


527105
HNRPDL
Heterogeneous nuclear ribonucleoprotein D-like
215.39
95.16
0.207


527193
RPS23
Ribosomal protein S23
178.23
128.51
0.207


527348
AKAP9
A kinase (PRKA) anchor protein (Yotiao) 9
103.64
60.76
0.310


527412
ASAH1
N-acylsphingosine amidohydrolase (acid ceramidase) 1
216.47
95.28
0.241


527861
OS9
Amplified in osteosarcoma
317.55
151.86
0.138


527862
PKD1
Hypothetical protein LOC339047
142.25
87.72
0.345


527980
DUT
DUTP pyrophosphatase
150.77
79.02
0.207


528050
HARS
Histidyl-tRNA synthetase
171.62
84.32
0.138


528222
NDUFS4
NADH dehydrogenase (ubiquinone) Fe—S protein 4, 18 kDa
112.10
94.04
0.276




(NADH-coenzyme Q reductase)





528300
PITRM1
Pitrilysin metallopeptidase 1
122.00
61.07
0.276


528305
DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
298.20
91.95
0.138


528572
SORBS3
Sorbin and SH3 domain containing 3
187.70
104.57
0.345


528668
RPL6
Ribosomal protein L6
1037.68
85.03
0.034


528780
GSPT1
G1 to S phase transition 1
170.88
56.71
0.138


528803
UQCRC2
Ubiquinol-cytochrome c reductase core protein II
272.39
84.82
0.103


529059
EIF3S4
Eukaryotic translation initiation factor 3, subunit 4 delta, 44 kDa
311.33
92.44
0.172


529132
SEPW1
Selenoprotein W 1
231.08
110.89
0.276


529244
NCK2
NCK adaptor protein 2
236.70
169.13
0.345


529280
ANAPC7
Anaphase promoting complex subunit 7
94.04
52.31
0.379


529303
ARPC2
Actin related protein 2/3 complex, subunit 2, 34 kDa
329.77
127.35
0.034


529369
AFAP1
Actin filament associated protein 1
101.03
56.96
0.379


529400
IFNAR1
Interferon (alpha, beta and omega) receptor 1
108.71
56.53
0.310


529420
UBE2G2
Ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)
160.64
100.65
0.103


529591
TLOC1
Translocation protein 1
141.82
65.80
0.172


529618
TFRC
Transferrin receptor (p90, CD71)
212.76
85.52
0.241


529631
RPL35A
Ribosomal protein L35a
453.58
173.13
0.103


529782
VCP
Valosin-containing protein
532.58
85.03
0.034


529798
BTF3
Basic transcription factor 3
400.11
94.96
0.069


529862
CSNK1A1
Casein kinase 1, alpha 1
210.72
69.09
0.103


529890
CANX
Calnexin
399.31
129.28
0.069


529892
SQSTM1
Sequestosome 1
789.12
108.86
0.034


529957
SEC63
SEC63-like (S. cerevisiae)
120.12
80.80
0.276


530096
EIF3S2
Eukaryotic translation initiation factor 3, subunit 2 beta, 36 kDa
451.94
86.61
0.034


530118
LUC7L2
LUC7-like 2 (S. cerevisiae)
132.76
59.55
0.172


530291
ANXA11
Annexin A11
279.25
86.71
0.069


530314
SSNA1
Sjogren's syndrome nuclear autoantigen 1
122.20
58.54
0.379


530331
PDHA1
Pyruvate dehydrogenase (lipoamide) alpha 1
179.99
79.37
0.207


530381
PIM3
Pim-3 oncogene
114.61
72.86
0.345


530412
SERBP1
SERPINE1 mRNA binding protein 1
289.56
66.47
0.069


530436
STXBP3
Syntaxin binding protein 3
113.84
77.40
0.276


530479
PMF1
Polyamine-modulated factor 1
128.35
73.53
0.241


530687
RNH1
Ribonuclease/angiogenin inhibitor 1
342.47
102.27
0.172


530734
MRPL16
Mitochondrial ribosomal protein L16
106.22
67.89
0.345


530753
C11orf59
Chromosome 11 open reading frame 59
153.75
63.46
0.276


530823
COPS7A
COP9 constitutive photomorphogenic homolog subunit 7A
202.70
132.83
0.138




(Arabidopsis)





530862
PRKAG1
Protein kinase, AMP-activated, gamma 1 non-catalytic subunit
136.75
73.16
0.241


531081
LGALS3
Lectin, galactoside-binding, soluble, 3 (galectin 3)
318.01
134.08
0.241


531089
PSMA3
Proteasome (prosome, macropain) subunit, alpha type, 3
218.40
93.16
0.276


531176
SARS
Seryl-tRNA synthetase
297.55
88.08
0.138


531330
CBWD1
COBW domain containing 2
123.09
79.22
0.310


531614
BTBD14B
BTB (POZ) domain containing 14B
123.09
63.39
0.310


531752
RANBP3
RAN binding protein 3
122.49
64.65
0.310


531856
GAS5
Growth arrest-specific 5
227.80
134.55
0.241


531876
DYNLRB1
Dynein, light chain, roadblock-type 1
167.51
104.22
0.241


531879
RAD1
RAD1 homolog (S. pombe)
115.15
74.02
0.379


532359
RPL5
Ribosomal protein L5
747.39
72.96
0.000


532399
ZC3H11A
Zinc finger CCCH-type containing 11A
139.50
74.48
0.241


532755
C16orf80
Chromosome 16 open reading frame 80
95.17
63.38
0.207


532790
NMT1
N-myristoyltransferase 1
165.97
105.96
0.172


532793
KPNB1
Karyopherin (importin) beta 1
568.94
129.62
0.000


532803
HN1
Hematological and neurological expressed 1
225.82
90.89
0.103


532826
MCL1
Myeloid cell leukemia sequence 1 (BCL2-related)
252.48
83.80
0.207


532853
NDUFB7
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18 kDa
145.80
84.03
0.345


533030
TRIOBP
TRIO and F-actin binding protein
339.95
148.19
0.207


533059
TUBB
Tubulin, beta polypeptide
2476.41
87.07
0.000


533122
SFRS10
Splicing factor, arginine/serine-rich 10 (transformer 2 homolog,
182.52
60.97
0.034




Drosophila)





533136
LRPAP1
Low density lipoprotein receptor-related protein associated protein 1
234.76
108.38
0.207


533192
TOMM20
Translocase of outer mitochondrial membrane 20 homolog (yeast)
208.87
77.43
0.138


533222
DIMT1L
DIM1 dimethyladenosine transferase 1-like (S. cerevisiae)
129.17
69.14
0.379


533245
DDX46
DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
118.53
50.97
0.345


533282
NONO
Non-POU domain containing, octamer-binding
842.92
104.94
0.034


533308
PPP2R5D
Protein phosphatase 2, regulatory subunit B (B56), delta isoform
223.23
100.62
0.138


533317
VIM
Vimentin
1800.81
137.19
0.069


533437
TCEB1
Transcription elongation factor B (SIII), polypeptide 1 (15 kDa,
121.08
94.03
0.276




elongin C)





533440
WWP1
WW domain containing E3 ubiquitin protein ligase 1
146.51
87.93
0.345


533474
PPP1R8
Protein phosphatase 1, regulatory (inhibitor) subunit 8
95.08
118.26
0.379


533479
LYPLA2
Lysophospholipase II
223.79
59.26
0.276


533526
ATRX
Alpha thalassemia/mental retardation syndrome X-linked (RAD54
149.83
61.38
0.276




homolog, S. cerevisiae)





533624
H3F3A
H3 histone, family 3A
322.44
81.23
0.103


533712
RBM4
RNA binding motif protein 4
169.22
66.18
0.138


533732
SRP14
Signal recognition particle 14 kDa (homologous Alu RNA binding
223.87
85.87
0.172




protein)





533771
STUB1
STIP1 homology and U-box containing protein 1
238.45
84.03
0.241


533782
KRT8
Keratin 8
1307.25
94.61
0.379


533977
TXNIP
Thioredoxin interacting protein
429.73
92.27
0.034


533985
EXOC7
Exocyst complex component 7
168.92
93.23
0.276


533986
ZMYM6
Zinc finger, MYM-type 6
99.16
62.99
0.310


534125
HLA-C
Major histocompatibility complex, class I, C
610.10
155.80
0.034


534168
NDUFA1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5 kDa
261.51
202.07
0.310


534212
SEC22B
SEC22 vesicle trafficking protein homolog B (S. cerevisiae)
107.96
68.79
0.379


534255
B2M
Beta-2-microglobulin
1303.98
172.16
0.000


534307
CCND3
Cyclin D3
471.76
356.89
0.207


534314
EIF5A
Eukaryotic translation initiation factor 5A
438.38
88.29
0.207


534326
ITGB4BP
Integrin beta 4 binding protein
360.06
78.91
0.103


534338
PPP4C
Protein phosphatase 4 (formerly X), catalytic subunit
191.52
75.42
0.138


534346
RPS7
Ribosomal protein S7
572.81
120.27
0.000


534350
SMARCB1
SWI/SNF related, matrix associated, actin dependent regulator of
210.96
162.57
0.172




chromatin, subfamily b, member 1





534453
NDUFA13
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
194.91
119.87
0.138


534456
ANAPC11
APC11 anaphase promoting complex subunit 11 homolog (yeast)
164.01
99.17
0.172


534457
C14orf166
Chromosome 14 open reading frame 166
171.37
66.04
0.138


534473
TOMM22
Translocase of outer mitochondrial membrane 22 homolog (yeast)
144.72
100.10
0.207


534483
PHF23
PHD finger protein 23
123.34
63.04
0.276


536275
PACS1
Phosphofurin acidic cluster sorting protein 1
217.82
86.00
0.345


541269
NDUFB9
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22 kDa
269.72
132.31
0.172


546248
CTSD
Cathepsin D (lysosomal aspartyl peptidase)
660.73
119.52
0.103


546250
DYNC1I2
Dynein, cytoplasmic 1, intermediate chain 2
154.54
71.13
0.172


546253
FDFT1
Farnesyl-diphosphate farnesyltransferase 1
249.53
81.90
0.034


546261
HNRPA1
Heterogeneous nuclear ribonucleoprotein A1
649.46
94.55
0.000


546269
RPL10A
Ribosomal protein L10a
706.14
175.46
0.103


546271
PCBP2
Poly(rC) binding protein 2
293.34
87.15
0.103


546286
RPS3
Ribosomal protein S3
2290.87
95.60
0.000


546289
RPS12
Ribosomal protein S12
527.74
281.85
0.103


546290
RPS18
Ribosomal protein S18
939.29
233.81
0.069


546291
RPS27
Ribosomal protein S27 (metallopanstimulin 1)
725.59
382.56
0.172


546339
C11orf58
Chromosome 11 open reading frame 58
580.69
190.75
0.138


546356
RPL13A
Ribosomal protein L13a
1352.43
84.32
0.000


546394
CCDC72
Coiled-coil domain containing 72
244.28
200.01
0.241


547759
SSBP3
Single stranded DNA binding protein 3
124.35
57.76
0.310


549178
C9orf86
Chromosome 9 open reading frame 86
219.13
114.79
0.138


552590
HTF9C
HpaII tiny fragments locus 9C
107.24
77.34
0.276


553496
PGM3
Phosphoglucomutase 3
103.08
61.39
0.379


553512
MBOAT5
Membrane bound O-acyltransferase domain containing 5
124.81
75.10
0.310


554767
NUP88
Nucleoporin 88 kDa
120.01
86.75
0.345


554776
SREBF1
Sterol regulatory element binding transcription factor 1
171.91
88.02
0.276


554894
WDR54
WD repeat domain 54
114.62
72.99
0.345


554896
C7orf50
Chromosome 7 open reading frame 50
193.18
101.69
0.207


555194
FAM36A
Family with sequence similarity 36, member A
120.40
52.67
0.276


555866
C1QBP
Complement component 1, q subcomponent binding protein
312.33
77.95
0.138


555873
HNRPAB
Heterogeneous nuclear ribonucleoprotein A/B
316.21
89.74
0.034


555875
IDH3A
Isocitrate dehydrogenase 3 (NAD+) alpha
143.01
87.51
0.345


555889
PSMC2
Proteasome (prosome, macropain) 26S subunit, ATPase, 2
219.37
69.24
0.172


555890
RBBP4
Retinoblastoma binding protein 4
204.72
80.47
0.172


555911
RBM8A
RNA binding motif protein 8A
125.26
75.03
0.172


555969
RIC8A
Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)
261.31
93.56
0.172


555971
TMBIM1
Transmembrane BAX inhibitor motif containing
219.28
114.17
0.207


555973
MRPS25
Mitochondrial ribosomal protein S25
152.15
62.00
0.207


555994
LONP2
Ion peptidase 2, peroxisomal
135.95
87.69
0.379


556267
FBXL10
F-box and leucine-rich repeat protein 10
81.84
65.86
0.379


556461
NDUFV2
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24 kDa
146.86
108.59
0.207


556795
PAICS
Phosphoribosylaminoimidazole carboxylase,
253.76
89.34
0.138




phosphoribosylaminoimidazole succinocarboxamide synthetase





557550
NPM1
Nucleophosmin (nucleolar phosphoprotein B23, numatrin)
1675.95
168.64
0.000


558296
ACP1
Acid phosphatase 1, soluble
123.81
58.79
0.172


558313
COX6A1
Cytochrome c oxidase subunit VIa polypeptide 1
170.58
93.53
0.241


558322
EEF1B2
Eukaryotic translation elongation factor 1 beta 2
450.71
94.79
0.034


558325
EIF5
Eukaryotic translation inititation factor 5
232.38
85.09
0.172


558328
FKBP5
FK506 binding protein 5
117.84
59.52
0.310


558330
FTL
Ferritin, light polypeptide
2521.41
158.72
0.069


558338
HSPE1
Heat shock 10 kDa protein 1 (chaperonin 10)
270.37
133.18
0.207


558345
IK
IK cytokine, down-regulator of HLA II
252.13
99.25
0.138


558354
RPSA
Ribosomal protein SA
1322.76
86.38
0.034


558360
NDUFB4
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15 kDa
211.99
145.77
0.345


558361
NME2
Non-metastatic cells 2, protein (NM23B) expressed in
300.76
113.65
0.276


558362
NUMA1
Nuclear mitotic apparatus protein 1
186.63
72.04
0.207


558376
RAC1
Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP
310.27
151.23
0.000




binding protein Rac1)





558381
SNORA65
Small nucleolar RNA, H/ACA box 65
182.13
140.06
0.172


558382
RPL15
Ribosomal protein L15
675.76
128.40
0.000


558383
RPL18A
Ribosomal protein L18a
705.56
175.27
0.034


558384
RPL19
Ribosomal protein L19
526.89
137.15
0.034


558385
RPL23A
Ribosomal protein L23a
699.13
138.42
0.069


558386
RPL34
Ribosomal protein L34
697.35
378.17
0.069


558388
RPS3A
Ribosomal protein S3A
2474.40
122.86
0.034


558389
RPS8
Ribosomal protein S8
962.64
129.92
0.000


558390
RPS24
Ribosomal protein S24
612.43
101.36
0.034


558391
RPS26
Ribosomal protein S26
165.48
119.11
0.276


558396
SCD
Stearoyl-CoA desaturase (delta-9-desaturase)
914.63
104.45
0.069


558424
CSDA
Cold shock domain protein A
226.19
107.82
0.103


558426
EIF3S5
Eukaryotic translation initiation factor 3, subunit 5 epsilon, 47 kDa
303.80
92.52
0.172


558429
BUD31
BUD31 homolog (S. cerevisiae)
144.18
63.32
0.172


558431
RPL14
Ribosomal protein L14
572.84
76.90
0.069


558442
PDCD6IP
Programmed cell death 6 interacting protein
197.37
92.14
0.241


558448
TXNL2
Thioredoxin-like 2
190.19
99.31
0.276


558453
ATP5L
ATP synthase, H+ transporting, mitochondrial F0 complex, subunig
303.51
169.99
0.172


558454
NUDC
Nuclear distribution gene C homolog (A. nidulans)
366.87
118.17
0.207


558458
COPS8
COP9 constitutive photomorphogenic homolog subunit 8
143.44
86.61
0.207




(Arabidopsis)





558473
C18orf10
Chromosome 18 open reading frame 10
143.75
80.47
0.172


558499
CD320
CD320 molecule
188.81
75.95
0.379


558511
PARL
Presenilin associated, rhomboid-like
126.27
91.30
0.276


558521
C2orf33
Chromosome 2 open reading frame 33
133.19
79.12
0.241


558591
ORMDL1
ORM1-like 1 (S. cerevisiae)
156.16
85.13
0.345


558825
PDE4DIP
Phosphodiesterase 4D interacting protein (myomegalin)
192.79
111.41
0.241


558995
C1orf151
Chromosome 1 open reading frame 151
718.64
244.03
0.103


567260
CD2BP2
CD2 antigen (cytoplasmic tail) binding protein 2
161.65
79.42
0.207


567263
C1orf43
Chromosome 1 open reading frame 43
337.41
80.70
0.172


567267
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
95.02
60.83
0.345


567279
SAP30BP
SAP30 binding protein
178.67
103.35
0.207


















Genomic Variants on Human


Uni-



Genome Assembly Build 36













Gene
SHORT SAGE
LONG SAGE
Affymetrix


Locus


















cluster
Mean
CV
0's P
Mean
CV
0's P
Mean
CV
Variation
Cytogen
ID





  120
222.30
77.57
0.000
182.28
77.83
0.000
536.31
44.78
CopyNumber
1q25.1
177


  142
177.46
78.94
0.036
83.00
75.28
0.000


CopyNumber
16p11.2
2900


  202
233.57
113.47
0.000
199.28
96.07
0.111
419.21
51.49





  429
522.98
82.18
0.000
551.21
81.48
0.000
865.18
43.60





  695
151.39
90.92
0.000
118.87
85.62
0.111
1052.98
100.96
CopyNumber
21q22.3
3455


  808
137.03
66.96
0.000
135.76
77.44
0.222
210.67
38.17





  861
68.60
107.22
0.000
36.11
50.87
0.222
127.15
87.08
CopyNumber
16p11.2
2903


 1063
96.52
67.18
0.036
100.31
75.40
0.222
194.60
33.14





 1103
106.49
111.80
0.036
125.52
97.41
0.111
106.24
57.23





 2430
41.98
80.01
0.071
47.30
88.89
0.222
218.15
32.90





 2533
60.36
77.46
0.071
74.01
77.57
0.111
354.31
47.43





 2795
334.22
95.03
0.000
259.59
82.14
0.111
2250.38
43.77





 2853
154.67
63.43
0.036
186.93
60.34
0.111
926.32
22.95





 3100
67.12
76.40
0.000
61.24
67.08
0.222
517.42
29.81





 3254
97.41
78.32
0.036
113.88
73.94
0.111
211.49
31.45
Inversion
11p15.5
2202


 3353
78.09
56.37
0.071
216.42
70.65
0.000
881.36
27.96





 3416
109.67
131.08
0.036
68.67
112.87
0.222
360.44
151.18
CopyNumber
9p22.1
1912


 3439
70.64
80.75
0.036
89.54
93.24
0.111
191.34
38.33





 3530
79.35
72.15
0.036
108.31
56.32
0.000
136.00
30.88





 3989
98.71
108.38
0.036
134.74
83.01
0.111
427.22
43.37





 4055
257.29
135.83
0.000
441.94
118.93
0.111
64.49
38.32





 4742
107.98
119.15
0.036
39.71
65.93
0.222
275.64
44.77
CopyNumber
8q24.3
1879


 4747
62.19
73.50
0.071
71.07
73.04
0.111
307.46
47.47





 4766
55.17
86.86
0.036
72.60
84.36
0.222
262.05
27.51





 4859
101.90
103.29
0.071
110.40
111.52
0.000
299.38
40.44





 4997
65.10
62.12
0.000
50.72
94.59
0.111
264.44
22.10





 4998
60.81
63.22
0.036
28.78
51.61
0.222
229.36
56.84





 5062
333.07
101.42
0.000
111.82
81.88
0.111
800.47
52.13
CopyNumber
15q24.3
2811


 5086
62.72
72.25
0.036
53.42
73.36
0.222
135.70
28.77





 5120
212.71
71.64
0.000
204.68
69.54
0.111
1158.59
29.63





 5158
163.14
67.54
0.000
138.55
60.73
0.111
383.95
36.39





 5245
64.41
74.90
0.000
80.69
73.69
0.000
219.54
21.60





 5258
122.13
84.40
0.071
133.74
77.92
0.111
589.76
55.05





 5268
71.67
78.70
0.000
46.25
73.83
0.111
113.40
37.54





 5298
78.91
59.08
0.000
58.54
49.70
0.111
296.11
31.82





 5308
354.49
83.81
0.000
479.50
73.38
0.000
2422.20
38.02





 5324
73.70
64.23
0.000
62.22
66.74
0.111
694.81
25.69





 5345
69.83
86.81
0.071
61.41
84.79
0.111
73.49
30.51
CopyNumber
2q37.3
515


 5662
632.04
87.26
0.000
651.22
57.10
0.000
2861.36
36.28





 5710
58.67
67.53
0.071
34.13
80.74
0.111
452.86
45.78





 5719
289.65
94.26
0.000
65.99
56.36
0.000
55.53
45.18
CopyNumber
12p13.31
2368


 5912
53.23
65.61
0.000
30.20
60.87
0.111
430.78
30.03





 5947
44.57
68.42
0.036
34.91
59.37
0.222
368.59
33.28





 6396
138.04
72.90
0.036
94.01
39.56
0.222
869.88
31.02





 6454
233.69
77.38
0.000
290.31
91.04
0.000
504.85
40.25
CopyNumber
19p13.12
3223


 6459
117.70
121.97
0.036
88.34
85.38
0.111
157.79
41.08
CopyNumber
8q24.3
1880


 6551
113.84
102.10
0.000
99.28
83.28
0.000
515.56
45.37





 6891
113.93
68.55
0.000
79.36
95.32
0.000
437.26
34.58





 7101
57.03
85.77
0.071
81.04
84.26
0.000
183.19
27.20





 7236
73.56
91.55
0.000
89.02
123.50
0.111
150.63
53.39
CopyNumber
19q13.33
3277


 7476
134.42
85.55
0.000
91.48
67.53
0.000
1250.83
39.30





 7527
91.89
92.63
0.036
52.36
54.01
0.222
97.43
36.93





 7744
253.95
85.28
0.000
77.42
71.13
0.000
415.46
37.27
CopyNumber
11q13.1-11q13.2
2278


 7753
200.10
136.12
0.000
138.00
85.95
0.111
100.65
48.84
CopyNumber
7q32.1
1639


 7768
81.86
65.21
0.000
63.80
65.95
0.111
269.17
27.39
CopyNumber
11q13.1
2276


 7862
93.55
74.15
0.036
84.67
63.85
0.111







 7910
165.96
72.05
0.036
78.63
65.90
0.111
153.70
42.23





 7917
249.49
78.00
0.000
135.78
112.82
0.111
661.73
52.63
CopyNumber
3p22.1
572


 8102
918.89
83.01
0.000
1410.01
75.01
0.000
4250.06
30.72





 8372
357.79
108.88
0.000
146.74
79.82
0.111
788.19
32.34





 8737
102.30
68.38
0.036
88.71
85.75
0.111
253.06
44.11





 8752
56.83
57.76
0.071
52.10
62.17
0.222
102.13
32.76
CopyNumber
12q13.2
2429


 8765
48.25
64.21
0.000
53.71
59.12
0.000
228.43
30.56





 8859
74.83
111.07
0.036
53.33
94.17
0.222
234.96
73.37





 8867
187.29
137.92
0.000
273.81
95.23
0.111
547.98
79.93





 9003
73.69
69.05
0.000
66.15
65.61
0.000
148.11
36.69





 9015
184.94
65.95
0.000
180.11
68.32
0.000







 9043
56.29
67.83
0.000
38.48
97.33
0.111
162.00
25.78





 9234
68.85
79.49
0.071
68.18
62.80
0.111
434.76
37.42





 9235
93.18
92.25
0.000
67.77
88.26
0.222
256.46
58.39





 9527
81.51
84.48
0.036
51.11
48.09
0.222
538.70
28.49





 9534
98.58
72.74
0.000
86.28
73.16
0.222
626.14
29.63





 9573
46.97
92.63
0.036
31.79
54.71
0.222
778.41
33.32





 9589
75.93
61.30
0.036
71.77
49.75
0.111
919.32
26.81





 9788
82.06
88.77
0.071
127.59
72.78
0.000
377.13
38.24





 9825
76.79
66.79
0.000
56.23
48.85
0.111
365.07
28.07





 9857
194.06
122.60
0.000
232.82
151.99
0.000
463.40
157.98





 10326
164.06
73.58
0.000
197.00
75.36
0.000
369.97
68.55





 10842
182.70
94.54
0.000
239.28
115.19
0.222
718.72
44.58





 10848
38.94
67.53
0.071
31.76
66.74
0.111
104.71
37.33
CopyNumber
10q11.21
2093


 11125
94.29
68.78
0.071
93.47
59.46
0.000
817.21
27.49





 11184
129.52
59.84
0.036
115.93
46.13
0.000
292.68
27.77
CopyNumber
9p13.3
1937


 11223
52.37
88.67
0.071
78.63
87.24
0.222
57.89
55.15





 11355
63.16
104.32
0.036
66.99
75.00
0.222
62.56
35.20





 11463
123.53
61.89
0.036
113.19
84.50
0.111
429.95
40.75





 12013
47.30
64.76
0.036
45.75
69.36
0.222
99.02
32.35





 12084
235.78
81.01
0.000
364.40
89.06
0.000
623.07
39.39
CopyNumber
16p11.2
2900


 12102
131.08
67.05
0.071
114.17
52.22
0.111
518.73
22.82
CopyNumber
6q21
1407


 12107
76.75
72.91
0.036
50.80
59.67
0.111
329.36
29.47





 12109
66.06
61.69
0.036
46.73
59.25
0.111
118.79
29.00
CopyNumber
2q11.2
378


 12144
39.29
73.94
0.071
41.87
82.28
0.222
162.21
31.04





 12152
64.91
79.55
0.036
58.29
64.64
0.222
30.47
58.95





 12272
50.41
64.89
0.071
48.28
64.28
0.111
236.82
29.21





 12341
99.54
71.85
0.000
80.90
63.60
0.222
646.53
35.91





 12457
69.13
60.75
0.036
41.32
44.32
0.222
141.28
35.86





 12865
48.09
77.51
0.036
56.10
68.14
0.111
161.87
24.52





 13662
52.31
73.45
0.071
42.54
82.56
0.111
286.77
29.53





 14317
169.22
85.06
0.000
210.81
76.29
0.111
707.56
30.56
CopyNumber
15q14
2760


 14333
150.04
93.92
0.000
49.69
65.95
0.222
52.91
32.36
CopyNumber
1p36.11
49


 14745
86.24
67.71
0.036
34.86
68.85
0.222
344.17
44.46





 14839
89.01
60.79
0.036
72.24
59.97
0.000
425.45
27.99
CopyNumber
11q12.3
2269


 14846
60.63
71.11
0.036
35.42
56.40
0.111
290.22
58.28





 14894
121.24
82.05
0.000
60.76
70.36
0.111
126.08
28.41





 15277
84.56
127.86
0.000
94.06
82.10
0.111
147.72
37.89
CopyNumber
16p13.3
2866


 15591
83.92
67.01
0.000
41.12
58.74
0.111
131.70
28.53
CopyNumber
7q22.1
1598


 15738
120.91
72.04
0.000
129.69
48.46
0.111
417.14
23.56





 16059
96.29
66.35
0.000
71.91
74.39
0.111
679.76
46.08





 16130
63.36
62.56
0.036
43.34
61.70
0.222
18.64
94.29
CopyNumber
17q25.1
3075


 16349
39.01
59.57
0.071
31.68
64.66
0.222
148.04
24.93
CopyNumber
16q23.2
2956


 17118
67.64
62.14
0.071
46.03
69.29
0.111
213.73
40.31
CopyNumber
1p34.3
58


 17250
105.68
79.64
0.071
117.82
78.92
0.111
294.70
33.94





 17680
55.65
73.53
0.071
48.01
54.77
0.111
516.93
33.95
CopyNumber
6q24.2
1437


 17731
64.78
70.13
0.000
29.51
60.36
0.111
520.71
54.10





 17883
159.30
65.60
0.000
135.33
70.28
0.000
114.89
33.02





 18069
74.08
90.49
0.036
63.83
85.91
0.111
211.65
49.02





 18128
50.49
74.70
0.036
28.66
43.42
0.222
141.00
37.06
CopyNumber
20q11.22
3366


 18349
42.98
74.07
0.036
49.61
83.49
0.222
300.87
45.97





 19673
71.97
80.92
0.071
95.67
73.57
0.222
562.71
37.51
CopyNumber
8q24.3
1879


 20013
80.86
65.84
0.000
62.25
52.78
0.000
173.94
35.93
CopyNumber
1p36.11
48


 20107
78.88
96.88
0.036
39.46
139.41
0.222
175.52
41.33
CopyNumber
14q32.33
2746


 20157
79.43
77.35
0.036
59.44
87.93
0.222
376.62
32.83





 20521
131.53
94.01
0.000
152.96
89.93
0.111
383.24
40.81
CopyNumber
19q13.33
3277


 20529
50.65
69.78
0.071
39.76
53.17
0.222
749.10
34.18
CopyNumber
1p36.32
11


 20573
106.46
67.85
0.000
81.56
153.79
0.111
23.55
41.49





 20716
84.45
71.00
0.036
66.00
55.65
0.222
276.11
36.03
CopyNumber
1q32.1
209


 22393
66.26
64.62
0.036
63.67
82.21
0.222
228.15
33.72





 22543
92.47
56.69
0.036
63.96
65.55
0.222
34.14
49.75





 22546
52.24
71.92
0.036
42.45
98.37
0.222
651.22
63.93
CopyNumber
11q12.2
2266


 22616
39.21
75.10
0.071
35.69
58.10
0.222
144.92
52.15
CopyNumber
17p13.3
2978


 23033
38.96
58.71
0.071
39.15
53.57
0.222
341.82
43.42





 23111
48.89
77.82
0.071
52.47
83.58
0.222
105.11
33.54
CopyNumber
19p13.13
3220


 23978
63.83
66.48
0.036
58.25
63.84
0.222
128.24
28.55





 24301
85.97
143.33
0.036
116.94
59.98
0.111
286.08
26.26
CopyNumber
19p13.3
3198


 24379
110.66
89.22
0.000
90.75
71.03
0.000
479.98
29.85





 24601
156.54
136.75
0.000
195.56
129.74
0.222
34.60
49.50
CopyNumber
22q13.31
3508


 24950
142.46
186.79
0.071
189.81
135.70
0.222
307.39
104.91





 25155
72.57
120.45
0.071
52.76
77.03
0.222
204.80
58.51





 25450
64.55
206.58
0.036
103.43
106.19
0.222
124.80
61.30





 25723
67.63
98.01
0.036
74.46
92.32
0.111
204.78
31.78





 26010
141.32
107.96
0.036
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51.33
65.65
0.071
131.99
67.30
0.111
252.76
37.55





520313
179.75
83.70
0.036
103.31
73.66
0.000
842.14
32.44





520383
62.05
69.15
0.036
54.79
74.80
0.222
51.28
37.61





520421
142.93
121.20
0.071
155.06
87.58
0.111
2195.13
80.88





520459
291.72
84.53
0.000
159.85
66.78
0.111
399.69
40.23
InversionBreak-
7q11.23
1572











point













CopyNumber




520623
33.85
81.68
0.036
27.31
61.61
0.222
248.55
33.13





520640
1348.49
91.02
0.000
1961.29
60.59
0.111
5036.63
31.42
CopyNumber
7p22.1
1487


520740
116.36
85.41
0.000
97.72
112.58
0.111
187.18
70.60





520794
50.36
70.80
0.036
49.78
44.95
0.111
40.24
56.59
CopyNumber
7p13
1537


520898
454.52
110.99
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400.82
102.01
0.000
21.23
57.80





520943
219.24
59.21
0.000
305.60
62.29
0.000
662.42
26.48





520967
186.05
70.34
0.000
252.42
65.79
0.000
120.89
29.85
CopyNumber
7q11.23
1572


520973
466.81
130.49
0.000
298.97
145.41
0.111
1152.33
82.08
CopyNumber
7q11.23
1572


520974
260.44
80.79
0.036
179.20
74.93
0.111
1930.00
33.13
CopyNumber
7q11.23
1572


521064
78.88
70.08
0.071
60.61
80.98
0.111
558.65
43.97





521151
46.43
85.62
0.036
47.47
134.19
0.222
127.30
30.14





521289
86.72
65.97
0.036
64.57
62.31
0.222
236.18
49.64





521487
363.27
69.54
0.000
276.67
67.15
0.000
538.96
41.02





521640
1470.83
133.20
0.000
85.15
63.55
0.111
298.27
31.34





521809
78.57
69.55
0.000
72.24
94.32
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125.31
30.12
CopyNumber
9q34.3
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521903
224.92
143.71
0.000
176.08
67.76
0.000
27.38
72.01





521924
89.56
82.37
0.036
59.55
73.11
0.111
401.23
45.90





521969
136.30
86.81
0.000
55.63
96.01
0.000
400.95
33.05





521973
49.95
80.96
0.036
39.93
90.53
0.111
142.18
54.69





522074
98.72
162.66
0.071
183.70
145.60
0.000
75.36
43.60





522110
42.72
63.85
0.071
29.44
57.72
0.222
152.37
38.21





522114
155.26
58.16
0.000
93.47
54.91
0.000
909.36
30.72





522310
91.19
102.19
0.036
111.23
114.70
0.111
227.49
72.44





522373
323.96
177.96
0.000
134.50
163.88
0.111
1015.67
83.01





522394
784.29
84.47
0.000
695.64
96.96
0.000
892.36
34.63





522463
3936.86
71.14
0.000
4621.60
78.17
0.000







522507
108.16
66.02
0.036
114.54
64.14
0.000
369.13
29.46
CopyNumber
9q34.3
2030


522584
1985.02
80.07
0.000
1864.38
65.53
0.000
2817.95
42.35





522590
125.35
65.85
0.000
87.04
74.78
0.111
155.78
39.35





522632
193.45
157.61
0.000
149.26
117.91
0.111
1399.30
82.97





522665
74.89
99.28
0.071
78.39
77.48
0.111
169.43
65.16





522675
56.35
68.02
0.071
35.39
56.96
0.222
89.16
49.55





522752
74.90
63.85
0.036
65.13
87.37
0.111
226.13
30.00





522817
110.80
92.87
0.000
243.72
76.57
0.000
446.45
43.91





522819
147.41
75.66
0.000
128.02
77.03
0.000
442.54
53.56





522823
89.83
65.96
0.000
55.52
55.51
0.111
80.40
39.08
Inversion
Xq28
3631


522932
63.66
74.41
0.071
62.12
87.31
0.222
932.94
35.74
CopyNumber
10q11.23
2097


522995
72.69
72.57
0.000
92.76
85.46
0.222
155.41
29.78





523004
854.93
91.74
0.000
1093.46
104.71
0.000
1020.96
39.57





523012
174.92
151.59
0.036
108.27
101.71
0.111
460.74
105.86





523054
109.08
58.03
0.000
85.81
56.99
0.111
215.84
28.86
CopyNumber
1p36.11
48


523131
61.64
64.37
0.036
54.95
87.13
0.000
176.91
27.06





523145
119.03
77.65
0.000
77.46
74.44
0.000
713.08
34.57





523215
132.65
72.87
0.000
87.19
71.68
0.111
515.77
29.73
CopyNumber
10q24.31
2164


523238
97.37
72.68
0.000
120.04
66.25
0.222
77.37
32.28





523262
168.88
70.08
0.036
131.35
69.97
0.000
1073.88
31.10





523299
112.29
84.00
0.071
94.08
72.86
0.222
94.93
27.98





523302
83.94
73.40
0.036
52.80
58.41
0.111
39.16
33.68





523560
822.83
81.28
0.000
971.82
62.39
0.000







523680
128.11
83.52
0.000
107.04
96.51
0.111
160.42
34.93





523789
400.45
160.56
0.000
399.15
138.88
0.000
126.46
81.17





523829
73.03
93.80
0.036
62.35
75.95
0.111
128.33
63.45





523836
390.11
118.62
0.000
551.15
91.25
0.000
692.25
64.89
CopyNumber
11q13.1-11q13.2
2278


523852
315.81
122.32
0.000
140.78
82.29
0.222
223.69
123.19
CopyNumber
11q13.2-11q13.3
2280


523875
52.62
85.23
0.036
67.45
82.01
0.222
138.28
32.54





524009
73.36
72.05
0.071
48.51
71.53
0.222
181.41
38.91





524081
43.70
79.74
0.036
25.40
66.56
0.222
131.07
30.87





524084
45.76
71.59
0.000
52.46
63.40
0.222
310.09
30.43





524161
81.94
56.55
0.071
58.04
46.88
0.000
158.34
33.48
CopyNumber
10p13
2062


524171
57.90
65.02
0.036
39.20
45.15
0.222







524183
195.27
99.77
0.036
250.38
82.32
0.111
259.10
66.52
CopyNumber
12p13.33
2363


524195
102.62
77.48
0.036
45.90
110.88
0.222
329.67
54.17





524214
109.61
65.06
0.000
93.97
80.62
0.111
429.42
38.04





524219
928.11
102.77
0.000
1283.75
138.72
0.000
1413.03
41.62





524271
59.03
101.04
0.000
72.07
117.41
0.111
303.87
28.52





524367
95.25
97.52
0.000
23.68
69.12
0.222
212.52
34.89





524395
779.97
160.71
0.071
629.43
152.46
0.111
691.04
113.98





524464
295.35
63.84
0.000
249.77
51.93
0.111
800.60
36.87





524502
55.12
63.30
0.036
38.16
53.21
0.222
35.02
67.39
CopyNumber
12q13.2
2429


524530
54.40
62.04
0.071
58.64
69.36
0.222
119.54
33.29





524590
39.33
62.24
0.071
32.90
59.64
0.222
168.27
24.98
CopyNumber
12q21.1
2454


524599
179.39
101.39
0.036
171.63
88.17
0.111
877.45
45.68





524690
60.86
157.16
0.071
37.45
91.05
0.222
129.11
25.70
CopyNumber
1p34.2
60


524788
47.40
66.86
0.071
46.71
77.38
0.222
152.65
26.13





524809
71.42
81.00
0.071
32.60
68.39
0.222
71.44
35.75





524899
89.47
64.26
0.000
95.67
74.61
0.222
638.70
30.17





524920
99.40
66.48
0.000
61.67
67.69
0.111
789.95
26.29





524969
85.23
65.49
0.000
50.51
61.47
0.222
159.56
35.37





525134
77.25
62.67
0.036
52.40
77.61
0.222
157.75
32.67





525163
92.10
68.79
0.036
118.15
66.40
0.000
209.09
38.04





525232
71.88
89.47
0.036
78.60
84.11
0.000
536.96
31.58





525238
130.29
93.87
0.000
59.16
67.35
0.111
602.44
37.66





525330
129.69
77.23
0.000
183.06
61.77
0.000
381.49
40.05





525391
44.15
59.57
0.036
42.13
65.68
0.222
156.20
32.83
CopyNumber
1p32.3
74


525527
57.33
71.43
0.071
100.14
58.46
0.111
184.06
29.23
CopyNumber
1p36.33-1p36.32
4


525626
36.14
70.54
0.036
28.27
80.56
0.222
93.85
33.60
CopyNumber
14q32.33
2747


525899
114.56
90.18
0.000
114.54
61.10
0.222
197.83
28.39





526464
75.33
68.99
0.036
26.13
58.80
0.222
142.58
30.88
CopyNumber
15q24.1
2808


526521
302.75
96.01
0.000
250.88
101.74
0.000
147.15
33.86





527105
425.77
68.10
0.000
371.42
53.26
0.000
445.41
26.61





527193
1153.32
66.74
0.000
1409.75
60.87
0.000
54.69
37.93





527348
39.34
68.02
0.071
31.17
107.14
0.111
156.88
41.93





527412
124.23
112.08
0.036
111.78
104.84
0.222
954.00
37.46





527861
157.27
75.05
0.000
174.55
93.72
0.000
778.13
44.76





527862
135.27
77.71
0.000
121.83
69.64
0.222


CopyNumber
16p13.3
2866


527980
96.02
93.19
0.000
140.08
80.91
0.111
72.21
28.28
CopyNumber
15q21.1
2774


528050
39.25
86.07
0.071
39.50
93.86
0.222
153.01
24.84





528222
72.79
71.25
0.000
56.92
67.43
0.222
297.99
38.18





528300
46.35
70.72
0.071
37.21
64.60
0.111
143.10
32.16
CopyNumber
10p15.2-10p15.3
2038


528305
235.95
69.32
0.000
323.87
54.84
0.000
1767.97
27.06





528572
62.31
107.18
0.036
40.58
69.71
0.222
121.35
39.94
CopyNumber
8p21.3
1710


528668
572.62
82.67
0.000
640.96
72.93
0.000







528780
73.97
78.91
0.036
95.64
74.72
0.111
545.27
28.60





528803
118.93
63.96
0.000
69.19
61.88
0.222
637.49
39.09
Inversion
16p12.2-16p12.1
2894


529059
112.54
86.70
0.000
155.84
79.33
0.000
436.61
43.10
CopyNumber
19p13.2
3216


529132
115.82
101.86
0.000
206.58
89.23
0.000
607.67
37.45





529244
42.17
79.26
0.036
48.81
59.97
0.222
299.18
31.69
CopyNumber
2q12.2
387


529280
51.63
59.84
0.036
42.59
87.27
0.222
122.27
29.28





529303
204.04
118.67
0.000
324.14
115.14
0.111
857.43
38.03





529369
54.85
89.29
0.000
25.26
76.50
0.111
9.01
69.95





529400
76.16
76.13
0.000
40.63
114.07
0.111
32.05
45.08





529420
928.90
107.73
0.000
106.80
48.77
0.000
56.41
37.58





529591
80.62
68.74
0.000
78.81
61.99
0.111
467.29
39.56





529618
89.51
87.09
0.036
82.62
91.59
0.111
36.01
56.84
CopyNumber
3q29
753











Inversion













CopyNumber




529631
891.99
74.72
0.000
620.31
56.60
0.000
176.79
30.79
CopyNumber
3q29
755


529782
173.75
58.53
0.000
130.67
66.49
0.000
146.41
27.77





529798
270.43
75.07
0.000
328.92
49.58
0.000
1755.52
30.60





529862
102.92
62.81
0.000
117.16
56.20
0.222







529890
448.92
63.76
0.000
331.32
41.79
0.000
3988.58
27.20
CopyNumber
5q35.3
1270


529892
194.96
108.94
0.036
139.13
107.43
0.222


CopyNumber
5q35.3
1271


529957
70.58
57.49
0.036
71.45
52.24
0.000
242.41
35.55





530096
284.86
68.28
0.000
137.92
57.16
0.111
422.18
29.43





530118
74.65
65.41
0.000
57.21
50.39
0.111
386.79
22.90





530291
75.64
94.65
0.000
62.14
78.23
0.000
77.23
37.30





530314
75.26
113.91
0.000
72.35
69.84
0.111
135.51
32.51
CopyNumber
9q34.3
2030


530331
104.89
79.95
0.071
96.65
72.31
0.111
393.16
48.43





530381
42.02
84.23
0.000
44.92
94.49
0.111
740.81
47.85





530412
569.26
108.42
0.000
884.31
121.35
0.000
755.69
25.73





530436
71.84
68.51
0.036
39.15
65.12
0.000
89.36
36.15





530479
60.22
68.09
0.071
50.16
67.87
0.222
130.74
30.76





530687
126.29
76.35
0.000
123.16
101.20
0.111
388.74
29.72
CopyNumber
11p15.5
2200


530734
48.51
78.25
0.036
43.82
67.00
0.222
203.80
36.73





530753
132.79
64.89
0.000
122.19
58.43
0.111
1049.37
27.21





530823
52.43
71.41
0.036
34.72
46.24
0.111
219.78
24.63





530862
38.26
76.97
0.071
24.06
57.79
0.111
216.03
27.91
CopyNumber
12q13.12
2421


531081
403.19
144.33
0.000
188.82
111.97
0.111
1778.83
73.47





531089
54.35
64.92
0.000
58.25
72.81
0.222
240.62
40.78





531176
137.35
69.91
0.036
192.02
57.22
0.111
407.01
25.65





531330
125.23
73.90
0.000
113.07
68.46
0.111
834.17
46.89
CopyNumber
9p24.3
1883


531614
79.33
75.55
0.071
84.93
89.38
0.111
260.94
66.65





531752
44.32
65.88
0.071
46.35
66.00
0.000
53.66
35.52





531856
609.96
113.19
0.000
567.60
102.77
0.000
10.32
101.76





531876
122.79
75.41
0.036
87.48
59.71
0.222
539.73
29.29





531879
58.80
73.81
0.071
33.40
53.04
0.111
88.51
36.03





532359
682.59
71.75
0.000
899.39
67.01
0.000
3112.89
40.25





532399
64.34
60.44
0.071
53.30
56.19
0.111
556.41
25.27





532755
37.29
59.70
0.071
35.53
57.88
0.222
174.78
35.47





532790
94.43
82.55
0.000
83.21
52.24
0.222
153.66
31.53





532793
88.10
105.70
0.036
160.69
81.87
0.111
299.76
37.08
CopyNumber
17q21.32
3031


532803
218.39
110.79
0.000
194.85
85.55
0.111
251.26
89.23





532826
221.93
124.52
0.036
436.04
83.52
0.000
55.92
39.14





532853
150.66
75.00
0.000
86.71
66.43
0.111
104.95
47.87





533030
108.55
90.84
0.036
91.99
90.93
0.111
235.53
30.97
CopyNumber
22q13.1
3496


533059
423.10
100.23
0.000
432.63
104.06
0.111
952.40
34.46
CopyNumber
6p21.33
1312


533122
111.10
60.64
0.071
124.04
67.72
0.000
610.09
26.23





533136
119.75
71.52
0.000
67.48
58.25
0.111
202.24
47.72
CopyNumber
4p16.2
761


533192
133.51
67.13
0.036
119.13
68.06
0.000
390.25
37.80





533222
42.41
60.55
0.071
36.87
44.13
0.111
164.72
28.30
CopyNumber
5q12.1
1137


533245
51.51
65.70
0.036
46.71
63.31
0.111
179.53
24.31
CopyNumber
5q31.1
1222


533282
184.07
56.67
0.000
183.69
77.18
0.000
1100.81
25.29





533308
47.46
68.45
0.036
48.77
64.22
0.222
202.26
24.39





533317
658.72
143.97
0.000
745.87
104.93
0.111
2393.96
70.88





533437
103.33
71.07
0.036
132.40
64.32
0.222







533440
60.09
143.68
0.036
45.51
61.68
0.222
235.54
58.67





533474
50.60
59.55
0.036
53.89
75.77
0.111
128.82
31.21





533479
107.17
69.59
0.036
96.22
76.98
0.111
86.44
31.09





533526
73.22
71.06
0.000
49.86
57.89
0.111
218.93
31.26





533624
986.85
70.85
0.000
959.57
58.54
0.000
1867.45
27.19





533712
54.47
65.23
0.036
55.59
73.88
0.222
259.05
30.12





533732
350.32
65.50
0.000
204.31
50.13
0.000
1297.83
21.87





533771
74.01
93.54
0.000
50.24
77.32
0.222
1094.17
25.43
CopyNumber
16p13.3
2866


533782
1096.00
221.65
0.036
544.77
104.33
0.222
29.71
50.29





533977
105.46
109.58
0.071
160.18
105.13
0.111
1758.85
51.28
CopyNumber
1q21.1
147


533985
83.81
197.67
0.036
55.92
64.84
0.111
188.23
31.85





533986
42.97
68.64
0.036
24.58
130.07
0.222
179.95
28.58





534125
477.32
142.62
0.000
832.59
105.81
0.111
4813.26
38.31
CopyNumber
6p21.33
1313


534168
304.79
75.97
0.036
323.99
55.72
0.000
1011.41
45.93
CopyNumber
Xq24
3602


534212
57.75
77.33
0.000
43.32
66.35
0.222
99.62
33.06
CopyNumber
1q21.1
147


534255
2594.12
96.87
0.000
2910.69
103.61
0.000
4736.90
32.54
CopyNumber
15q21.1
2773


534307
49.64
90.48
0.036
47.43
99.71
0.111
237.12
58.21





534314
745.09
85.64
0.000
902.22
82.80
0.000
123.06
45.02





534326
132.91
91.25
0.000
113.47
96.69
0.111
398.89
46.54





534338
85.04
66.09
0.036
78.26
71.00
0.222
158.13
58.47
CopyNumber
16p11.2
2903


534346
458.06
77.56
0.000
650.12
74.11
0.000







534350
56.06
71.06
0.071
29.73
56.39
0.222
141.64
41.82





534453
355.30
90.65
0.000
296.51
95.48
0.000
624.74
38.70





534456
159.17
130.28
0.000
192.47
72.01
0.000
88.66
32.89
CopyNumber
17q25.3
3087


534457
73.01
62.64
0.071
61.53
74.61
0.000
730.32
25.54





534473
64.20
63.86
0.071
93.62
63.87
0.222
453.91
46.23





534483
43.74
56.84
0.071
41.04
62.68
0.222
271.95
33.02





536275
46.64
69.43
0.071
36.99
76.62
0.222
305.46
30.60





541269
420.59
79.15
0.000
244.71
86.94
0.000







546248
104.98
137.05
0.036
819.47
122.30
0.000
277.15
66.77





546250
166.85
75.46
0.000
135.33
72.35
0.000
457.00
31.62





546253
124.83
79.22
0.036
154.37
88.05
0.222
80.29
33.55





546261
470.61
89.83
0.036
496.55
65.24
0.000
6040.82
27.54





546269
1748.03
75.45
0.000
1517.81
42.29
0.000
14429.75
31.95





546271
451.52
65.78
0.000
386.41
50.39
0.000
1283.29
34.90





546286
1021.82
89.05
0.000
1172.72
54.31
0.000
4362.29
39.28





546289
1459.28
108.77
0.000
1051.06
67.54
0.000
4831.90
38.49





546290
1853.80
94.06
0.000
2012.36
62.38
0.000
6697.93
38.63





546291
55.70
84.07
0.000
142.03
61.95
0.000
5073.35
34.62
CopyNumber
12p13.33-12p13.32
2364


546339
99.65
64.42
0.000
67.76
55.24
0.111
535.27
24.30





546356
3663.74
59.11
0.000
4388.69
51.21
0.000
6301.04
40.02
CopyNumber
19q13.33
3277


546394
175.77
111.80
0.000
185.13
58.61
0.000







547759
76.79
63.46
0.071
48.56
84.67
0.000







549178
106.75
82.90
0.000
82.93
55.18
0.111


CopyNumber
9q34.3
2030


552590
37.92
70.08
0.036
25.28
65.81
0.222


CopyNumber
22q11.21
3466


553496
48.42
72.62
0.071
41.08
79.89
0.222
43.50
72.79





553512
81.43
113.45
0.000
44.13
95.01
0.111







554767
41.31
64.47
0.071
35.90
65.85
0.222







554776
65.79
84.70
0.071
46.58
100.28
0.222


Inversion
17p11.2
2999


554894
48.56
87.26
0.071
45.88
73.07
0.222


CopyNumber
2p13.1
356


554896
156.46
89.43
0.000
112.49
60.07
0.000
291.19
31.70
CopyNumber
7p22.3
1481


555194
115.74
75.14
0.036
108.54
77.43
0.222







555866
179.94
100.49
0.000
206.53
89.92
0.000
185.01
47.68





555873
87.52
116.51
0.000
174.85
100.43
0.111







555875
43.03
78.46
0.036
17.73
91.10
0.222







555889
67.04
61.77
0.036
59.41
70.56
0.222







555890
148.13
64.41
0.000
151.98
72.68
0.111


CopyNumber
1p35.1
54


555911
110.86
83.61
0.000
120.74
64.55
0.000
182.74
32.39
CopyNumber
1q21.1
147


555969
42.50
85.57
0.036
27.90
60.28
0.222
187.95
28.62





555971
100.55
102.99
0.071
43.43
70.29
0.000







555973
47.22
61.02
0.071
25.39
54.32
0.222
365.86
37.66
CopyNumber
3p24.3
538


555994
37.87
67.15
0.071
17.47
70.28
0.222
113.88
43.85
CopyNumber
16q12.1
2912


556267
39.65
68.11
0.036
37.29
76.22
0.222







556461
99.23
109.80
0.000
89.26
94.15
0.111







556795
122.76
113.17
0.071
222.20
105.92
0.111







557550
707.78
90.20
0.000
781.42
91.24
0.000
2030.99
30.63





558296
76.31
65.84
0.000
71.76
64.47
0.222
293.40
20.63
CopyNumber
2p25.3
261


558313
268.12
83.46
0.000
103.84
61.28
0.111







558322
725.93
81.02
0.000
781.10
60.08
0.000







558325
121.20
58.04
0.071
105.00
59.17
0.000







558328
88.77
175.31
0.071
41.72
74.68
0.222
724.52
77.69
CopyNumber
6p21.31
1321


558330
1268.35
119.70
0.000
1306.25
81.82
0.000


CopyNumber
19q13.33
3275


558338
259.73
94.69
0.000
392.75
84.14
0.111







558345
52.12
68.96
0.036
47.70
48.55
0.222







558354
2215.71
85.28
0.000
3392.33
80.75
0.000







558360
213.80
85.52
0.000
198.33
51.08
0.111







558361
377.22
86.68
0.000
276.67
71.79
0.111







558362
70.26
74.08
0.036
45.59
64.87
0.222
229.35
49.45





558376
423.24
55.75
0.000
528.10
45.88
0.000







558381
167.44
127.10
0.000
52.20
90.63
0.000







558382
247.73
62.95
0.036
245.75
66.13
0.111







558383
1510.30
92.57
0.000
850.60
69.48
0.111







558384
913.52
70.50
0.000
972.23
66.45
0.000


CopyNumber
17q12
3020


558385
591.06
76.67
0.000
522.14
55.82
0.111







558386
994.94
70.79
0.000
1008.37
63.71
0.000







558388
1599.66
76.32
0.000
1561.96
59.50
0.000







558389
1884.53
86.31
0.000
2526.25
46.00
0.000







558390
1096.04
76.07
0.000
653.91
60.77
0.000







558391
1253.30
71.38
0.000
1018.49
62.26
0.000







558396
153.06
101.60
0.071
177.30
89.88
0.222
187.47
100.01





558424
153.84
92.40
0.000
144.32
74.76
0.000







558426
111.38
67.09
0.036
90.90
62.22
0.111







558429
74.41
78.14
0.036
73.01
72.78
0.111


CopyNumber
7q22.1
1597


558431
374.90
100.68
0.000
155.33
60.37
0.000







558442
62.39
68.18
0.000
51.45
69.20
0.000







558448
111.05
67.59
0.000
46.04
58.06
0.111







558453
614.08
82.84
0.000
530.26
57.92
0.000







558454
97.57
75.98
0.000
112.20
87.34
0.111


CopyNumber
1p36.11
49


558458
41.97
67.67
0.071
35.79
63.61
0.111







558473
66.89
70.64
0.000
40.37
55.42
0.222
104.21
36.46
CopyNumber
18q12.2
3132


558499
45.84
78.66
0.071
43.18
52.43
0.222
69.81
63.34
CopyNumber
19p13.2
3210


558511
60.47
54.61
0.000
46.40
50.18
0.222







558521
84.37
78.28
0.000
61.92
65.33
0.111







558591
92.26
68.02
0.071
85.80
56.76
0.111
687.61
32.03





558825
95.41
107.55
0.000
42.12
72.58
0.000


CopyNumber
1q21.1
147


558995
115.01
53.36
0.000
186.71
64.24
0.111







567260
55.10
63.25
0.036
44.20
70.83
0.222
14.03
385.13
CopyNumber
16p11.2
2903


567263
106.63
62.05
0.000
93.74
61.88
0.222
27.38
49.92





567267
74.61
57.55
0.036
44.12
65.62
0.000
26.18
56.35





567279
55.83
65.02
0.036
43.97
59.48
0.111


CopyNumber
17q25.1
3074





Mean: mean gene expression level,


CV: coefficient of variation,


0's P: 0's proportion






Example 3
Identification of ERG
Among the candidate ERGs, reference genes were further identified according to the following process.
First, CVs were calculated for each UniGene cluster in the datasets including EST, ShortSAGE, LongSAGE and microarray (Affymetrix HG-U133, CA), and genes were preferentially ranked in ascending order of CV. Out of the 400 genes (approx. 20% of the candidate ERG) which were preferentially ranked in ascending order of CV from each dataset, 13 ERGs were found to be common to all four datasets (Table 3). The 13 ERGs were identified as Accession No. Hs 500775(ZNF207), Accession No. Hs 446427(OAZ1), Accession No. Hs 530118(LUC7L2), Accession No. Hs 208597(CTBP1), Accession No. Hs 440382(TRIM27), Accession No. Hs 444279(GPBP1), Accession No. Hs 250009(ARL8B), Accession No. Hs 9589(UBQLN1), Accession No. Hs 253726(PAPOLA), Accession No. Hs 146806(CUL1), Accession No. Hs 533222(DIMT1L), Accession No. Hs 494985(FBXW2) and Accession No. Hs 242458(SPG21).
The gene ontology thereof was determined from a Gene Ontology site (http://www.geneontology.org/).
Most of the identified genes (ZNF207, OAZ1, CTBP1, PAPOLA, and FBXW2) were involved in basic cellular physiological processes, particularly in cellular metabolic processes. TRIM27 and CUL1 are genes responsible for cell proliferation. OAZ1 showed, the lowest CV in both ShortSAGE and LongSAGE. CTBP1 and ZNF207 were the most stable genes in CGAP and Microarray, respectively. OAZ1, which is involved in polyamine biosynthesis, showed the highest expression across all four datasets, with relatively low CV in all datasets except for the EST dataset.
Experimental Example 4
Correlation Analysis of Reference Gene between Datasets
Pearson and Spearman's rank correlation analyses were performed on the ERGs identified according to the present invention in a manner similar to that of Experimental Example 2 to compare the four datasets in terms of gene expression and CV.
Significant correlations between expression values were observed within some of the datasets, whereas no significant correlations of CV between any of the datasets were observed.
Although the Spearman correlation between EST-Microarray (0.374, P=0.206) and ShortSAGE-Microarray (0.511, P=0.076) was not significant, the gene expression of the 13 ERGs showed a significant Pearson correlation (p<0.001). No significant correlation in CV was found between the datasets (P>0.05). With the respective transcripts thereof found in all tissues in both ShortSAGE and LongSAGE, CDC42 and MYL6 were most stably expressed among the ERGs. HBP1 and PSMC1 showed the lowest CV in EST and Microarray.
Experimental Example 5
Comparison between Novel Reference Gene and Traditional Reference Gene in Gene Expression Datasets
The 13 endogenous reference genes identified according to the present invention were compared with 13 traditional reference genes (Table 4) in terms of gene expression level and CV.
As a result, the six traditional endogenous reference genes, RPLP0, ACTB, PPIA, GAPD, PGK1 and B2M, showed high expression levels, while the other genes, GUSB, HPRT1, TBP, TFRC, ALAS1, H6PD and HMBS, exhibited relatively low expression levels, in all four datasets (FIG. 6). These results are in line with those of the previous report, in which potential endogenous expression genes were analyzed for mRNA level using qRT-PCR (Radonic A et al., Biochem Biophys Res Commun, 313(4), 856-862, 2004). The expression levels of the endogenous reference genes identified according to the present invention were similar to or slightly higher than those of the low-abundance group of the traditional endogenous reference genes.
In addition, all of the endogenous reference genes identified according to the present invention, except for a few, showed lower CV values than traditional reference genes (FIG. 7). In other words, the endogenous reference genes of the present invention are generally low in expression variation across a wide range of tissues, indicating that the identified reference genes according to the present invention are more stably expressed than traditional endogenous reference genes.







TABLE 3





ERGs identified from four datasets

















UniGene
EST
SHORT SAGE















cluster
Symbol
Gene Title
Mean
CV
0's P
Mean
CV
0's P





Hs.446427
OAZ1
Ornithine decarboxylase
673.68
62.71
0.069
576.39
55.94
0




antizyme 1


Hs.9589
UBQLN1
Ubiquitin 1
111.34
60.19
0.31
75.93
61.3
0.036


Hs.444279
GPBP1
GC-rich promoter
132.98
56.92
0.241
63.11
61.63
0




binding protein 1


Hs.208597
CTBP1
C-terminal binding
136.74
48.53
0.138
213.99
62.01
0




protein 1


Hs.253726
PAPOLA
Poly(A) polymerase
216.15
65.36
0.172
118.24
58.02
0




alpha


Hs.250009
ARL8B
ADP-ribosylation factor-
132.27
55.79
0.379
134.21
61.55
0




like 8B


Hs.242458
SPG21
Spastic paraplegia 21
120.35
59.44
0.31
76.41
57.83
0.036




(autosomal recessive,




Mast syndrome)


Hs.530118
LUC7L2
LUC7-like 2 (S. cerevisiae)
132.76
59.55
0.172
74.65
65.41
0


Hs.500775
ZNF207
Zinc finger protein 207
233.29
62.27
0.034
165.68
56.77
0


Hs.533222
DIMT1L
DIM1 dimethyladenosine
129.17
69.14
0.379
42.41
60.55
0.071




transferase 1-like (S. cerevisiae)


Hs.440382
TRIM27
Tripartite motif
155.33
68.54
0.172
80.66
63.06
0




containing 27


Hs.146806
CUL1
Culin 1
120.27
57.5
0.207
69.33
65.76
0.036


Hs.494985
FBXW2
F-box and WD-40
97.45
68.65
0.379
40.27
58.47
0




domain protein 2













UniGene
LONG SAGE
Affymetrix
Gene Ontology














cluster
Mean
CV
0's P
Mean
CV
Biological Process
Molecular Function





Hs.446427
444.92
41.01
0
1860.9
22.07
Polyamine biosynthesis
Ornithine decarboxylase









inhibitor activity


Hs.9589
71.77
49.75
0.111
919.32
26.81

Kinase binding


Hs.444279
80.72
51.79
0.111
746.56
26.6


Hs.208597
112.96
50.6
0
481.51
24.72
Negative regulation of cell
Protein C-terminus








proliferation; Protein
binding Transcription








phosphorylation; Viral
factor binding








genome replication


Hs.253726
89.5
50.88
0
451.23
27.68
mRNA polyadenylation
RNA binding


Hs.250009
59.19
55.14
0.111
418.28
26.81
Chromosome segregation
α-tubulin binding;









β-tubulin binding; GDP









binding, GTP binding;









GTPase activity


Hs.242458
73.3
49.12
0
415.64
29.35
Antigen receptor-mediated
CD4 receptor binding








signaling pathway


Hs.530118
57.21
50.39
0.111
386.79
22.9


Hs.500775
154.32
52.88
0.111
358.69
18.38
Regulation of transcription,
Transcription factor








DNA-dependent
activity, Zinc ion binding


Hs.533222
36.87
44.13
0.111
164.72
28.3


Hs.440382
67.84
45.41
0.111
163.6
26.3
Cell proliferation
Metal ion binding








Spermatogenesis
Transmembrane receptor









protein tyrosine kinase









activity


Hs.146806
76.43
55
0.111
156.47
27.78
Cell cycle arrest; G1/S
Protein binding








transition of mitotic cell








cycle. Induction of








apoptosis by intracellular








signals Negative








regulation of cell








proliferation


Hs.494985
23.54
51.61
0.111
69.32
28.36
Proteolysis
Protein binding; ubiquitin









conjugating enzyme









activity; ubiquitin-protein









ligase activity





Mean: Mean gene expression level,


CV: Coefficient of variation,


0's P: 0's proportion













TABLE 4







Traditional EGRs used in present invention











UniGene
EST
SHORT SAGE
LONG SAGE
Affymetrix




















cluster
Symbol
Gene Title
Mean
CV
0's P
Mean
CV
0's P
Mean
CV
0's P
Mean
CV























Hs.448226
RPLP0
Ribosomal protein,
3,809.2
75.92
0
1,108.65
91.01
0
1,605.76
74.12
0
1,888.46
41.47




large, P0


Hs.520640
ACTB
β-actin
4,381.34
95.98
0.034
1,348.49
91.02
0
1,961.29
60.59
0.111
5,036.63
31.42


Hs.356331
PPIA
Peptidylprolyl
1,225.7
78.02
0.034
1,646.83
59.53
0
1,683.27
56.79
0
5,223.43
28.46




isomerase




A (cyclophilin A)


Hs.479728
GAPDH
Glyceraldehyde-3-
7,330.72
80.18
0
3,167.05
83.62
0
3,178.15
102.5
0
4,934.56
42.86




phosphate




dehydrogenase


Hs.78771
PGK1
Phosphoglycerate
681.19
86.72
0.034
423.67
85.52
0
445.96
90.9
0
1,179.63
41.05




kinase 1


Hs.534255
B2M
β-2-microglobulin
1,303.98
172.16
0
2,594.12
96.87
0
2,910.69
103.61
0
4,736.9
32.54


Hs.255230
GUSB
β-Glucuronidase
116.77
89.37
0.414
40.98
67.81
0.107
11.42
89.36
0.556
360.37
49.14


Hs.412707
HPRT1
Hypoxanthine
103.48
63.18
0.345
32.51
63.51
0.107
33.29
49.07
0.222
233.36
40.85




phosphor-




ibosyltransferase 1


Hs.1100
TBP
TATA box binding
71.46
47.77
0.448
31.94
62.8
0.286
17.58
69.22
0.444
25.44
73.23




protein


Hs.529618
TFRC
Transferrin receptor
212.76
85.52
0.241
89.51
87.09
0.036
82.62
91.59
0.111
36.01
56.84




(p90, CD71)


Hs.82609
HMBS
Hydroxy-
176.26
105.68
0.172
32.51
76.51
0.214
28.04
42.5
0.444
119.08
33.63




methylbilane




synthase


Hs.463511
H6PD
Hexose-6-
101.9
86.9
0.483
44.65
70.8
0.071
25.33
101.45
0.222
25.4
28.85




phosphate




dehydrogenase




(glucose-




1-dehydrogenase)


Hs.476308
ALAS1
δ-Aminolevulinate
132.82
82.5
0.345
50.43
72.23
0
22.5
50.59
0.222
178.95
107.93




synthase 1





Mean: Mean gene expression level,


CV: Coefficient of variation,


0's P: 0's proportion






Experimental Example 6
Gene Copy Number Variations of ERGs
The 13 ERGs identified according to the present invention were examined for gene copy number variation with reference to the Database of Genomic Variants (http://projects.tcag.ca/variation/). Only OAZ1 and DIMT1L, among the 13 genes of the present invention, were found in chromosome regions known to exhibit gene copy number variation (Table 5). In contrast, many (ACTB, GAPDH, PGK1, B2M, TBP, TFRC, ALAS1) of the traditional reference genes were located at such genomic loci (Table 5). These results suggest that almost all of the identified reference genes of the present invention, except for the two genes, can be used as guide genes for the measurement of gene amplification because they might be highly unlikely to show variation in gene copy number.
Experimental Example 7
Validation of Reference Gene
<7-1> Validation of Expression Level of ERG by Quantitative RT-PCR (qRT-PCR)
For use in validating the expression stability of the ERGs identified from the datasets, a total of 108 human samples, including 26 frozen human tissues, 60 formalin-fixed, paraffin embedded (FFPE) human tissues, and 22 human cancer cell lines were obtained (Table 6). The 60 FFPE tissues were composed of 10 breast cancer tissues, 8 normal stomach tissues, 9 stomach cancer tissues, 10 normal ovary tissues, 4 ovarian dropsy tissues, 9 borderline ovarian tumors, and 10 ovarian cancer tissues. Total RNA was isolated from these tissues and cell lines. For frozen human tissues and human cancer cell line samples, RNA which met the requirements of A260/280≧1.80 and rRNA (28S/18S)≧1.0 was used in qRT-PCR. cDNA was synthesized from the RNA using a standard technique and then diluted in distilled water (1:3 cDNA:DW) before qRT-PCR. PCR primers are summarized, together with the Universal Probe Library (UPL) thereof, in Table 7, below.
For use in this qRT-PCR, traditional ERGs were selected on the basis of the use frequency in previous reports and commercially available kits and the CV calculated from the database of the present invention. The 8 ERGs (B2M, ACTB, GAPDH, HMBS, PPIA, HPRT1, TBP and H6PD) that are most widely used can be found in commercially available kits such as Taqman human endogenous control plate (Applied Biosystems) and HKG selection kit (Roche Applied Science, Ohl F et, al., J Mol Med 83:1014-24, 2005; Roche Applied Science Technical Note No. LC 15/2005; Applied Biosystems, 2001). Each gene was measured at 530 nm using an FAM-conjugate UPL probe (Roche Applied Science) or a custom-made specific probe (TIB MOLBIOL GmbH, Germany). All PCR was performed in a Lightcycler 2.0 (Roche Applied Science, USA) using standard protocols.
PCR efficiency for each gene was measured using a cDNA serial dilution (Pfaffl M W et al., Nucleic Acids Res 29: e45, 2001) of the stomach cancer cell line MKN74 and calculated with Lightcycler software 4.0 (Roche Applied Science, USA). It was found to fall within a range from 90 to 100% (Table 8).
Also, PCR efficiency for each probe in tissue samples was estimated using a LinRegPCR program (Ramakers C et al., Neurosci Lett 339:62-6, 2003). A Cp value is an average of three measurements for each gene. The same genes from different tissue samples were measured under the same PCR conditions so as to minimize experimental variation. Because it was not measured in any of 4 samples, normal lung, liver, breast and kidney tissues, the Cp value of H6PD was omitted from subsequent calculations. For each experiment that was conducted in triplicate, the Cp values were found to have a CV less than 5%.
Expression levels of 20 genes, except for H6PD, across 48 samples, including frozen human tissues and cancer cell lines, are depicted in FIG. 8. The 13 novel ERGs of the present invention were expressed in all 48 samples. 7 traditional ERGs showed a wide expression range (Cp: 13.52 ̃29.39) whereas H6PD was not found in some tissues. The 13 ERGs ranged in Cp from 18.90 to 28.79 (FIG. 9). Traditional ERGs can be classified into a high-expression group (median <20 cycles) and a low-expression group (median >23 cycles). B2M, PPIA, GAPDH and ACTB are included in the high-expression group and HPRT1, TBP, and HMBS are found in the low-expression group. All of the novel ERGs of the present invention, except for OAZ1, show expression levels between those of the high-expression group and the low-expression group of the traditional ERGs. ZNF2007 had the highest expression level among the ERGs, followed by UBQLN1 and CUL1. OAZ1 had the lowest expression level.







TABLE 5







Gene copy number variations of traditional ERG and novel ERG








Novel candidate ERGs
Traditional ERGs












Gene
Genomic
Genomic Variation**
Gene
Genomic
Genomic Variation**
















Symbol
location*
Variation type
Locus ID
References
symbol
location*
Variation type
Locus ID
References



















ZNF207
17q11.2



RPLP0
12q24.23





OAZ1
19p13.3
Copy number
3199
Wong et al (2007)
ACTB
7p22.1
Copy number
1487
Wong et al (2007)


LUC7L2
7q34



PPIA
7p13


CTBP1
4p16.3



GAPDH
12p13.31
Copy number
2368
Redon et al (2006)


TRIM27
6p22.1



PGK1
Xq21.1
Copy number
3567
Iafrate et al (2004)


GPBP1
5q11.2



B2M
15q21.1
Copy number
2773
Redon et al (2006)


UBQLN1
9q21.33



GUSB
7q11.21


ARL8B
3p26.1



HPRT1
Xq26.2


PAPOLA
14q32.2



TBP
6q27
Copy number
1479
Redon et al (2006)


CUL1
7q36.1



TFRC
3q29
Copy number
753
Iafrate et al (2004)









Copy number

Redon et al (2006)


DIMT1L
5q12.1
Copy number
1137
Redon et al (2006)
HMBS
11q23.3


FBXW2
9q33.2



H6PD
1p36.22


SPG21
15q22.31



ALAS1
3p21.2
Copy number
590
Wong et al (2007)





*Genomic location was searched from Ensembl (http://www.ensembl.org/index.html)


**Genomic variations were searched in the Database of Genomic Variants (http://projects.tcag.ca/variation. Human Genome Assembly Build 36 (hg18)).






<7-2> Validation of ERG Using Expression Stability Based on qRT-PCR Data
Gene expression stability was analyzed using geNorm v3.4 software (Vandesompele J et al., Genome Biol 3:RESEARCH0034, 2002) and NormFinder software (Andersen C L et al., Cancer Res 64:5245-50, 2004). For geNorm and NormFinder analysis, Cp values were converted into relative expression levels in consideration of the PCR efficiencies of genes shown in Table 8 (GeNorm software manual, update on Sep. 6, 2004. //medgen.ugnet.be/ ̃jvdesomp/genorm/). Relative expression was calculated according to the following Mathematical Formula 4.

Relative Expression=(1+E)ΔCp  <Mathematical Formula 4>

    
    
        ΔCp=Minimum Cp−Sample Cp;
        Minimum Cp=lowest Cp value; and
        E=PCR Efficiency
    
    


Correlation between the gene expression stability calculated with the geNorm or NormFinder program (M by geNorm, S by NormFinder) and the CV calculated in each dataset was analyzed with R analysis software (//www.R-project.org).
All of the genes were found to have M values (<0.9) lower than the default limit, 1.5, of geNorm, with high expression stability, as analyzed using the geNorm program (Table 9). Lower M values for mean expression stability mean more stable expression. GPBP1 and CUL1 were observed to show the most stable expression. Among the genes analyzed, B2M is the lowest stable expression gene, with the highest M value of 0.888, followed by ACTB (M=0.843), HMBS (M=0.815) and GAPDH (M=0.793) in descending order of expression instability.
When using the NormFinder program, TBP and PAPOLA were ranked as the top two in terms of expression stability (Table 9). Consistent with the geNorm result, B2M, ACTB, GAPDH, HMBS and HPRT1 were found to be less stable in expression level than the novel ERGs of the present invention. Both programs demonstrated that most of the novel ERGs identified according to the present invention show more stable expression levels than do traditional ERGs. Further, when analyzed for gene expression stability using a LinRegPCR program on the basis of the relative expression calculated with PCR efficiency, most novel ERGs were found to maintain higher expression stability than traditional ERGs.
There is no significant correlation between the M values calculated with geNorm and the CV values in Microarray and LongSAGE (p>0.05), whereas significance was found in correlation between M values and CV values in EST (Pearson correlation coefficient: 0.676, p=0.001) and ShortSAGE (Pearson correlation coefficient: 0.659, p=0.002). Likewise, as for the Stability values (S), calculated with NormFinder, significant correlation was found in EST, ShortSAGE and LongSAGE, but not in microarray. Both the M and the S values showed higher agreement with CV in EST and ShortSAGE than in Affymetrix (Table 10).
Furthermore, the 13 novel ERGs were analyzed for expression in 60 FFPE samples using qRT-PCR in order to examine the possibility of applying them to the tissues in which high RNA degradation occurs. All of the genes, except for DIMT1L, were found to be expressed in all 60 samples. Cp was observed to range from 18.85 to 33.02 for traditional ERGs and from 23.33 to 31.38 for the novel ERGs (FIG. 9). Because of the lack of amplification in 5 samples, DIMT1L was omitted from subsequent stability analyses. Despite difference in the type of samples used in the experiments, almost all genes, except for several genes, were observed to be expressed in a pattern similar to that observed in the previous 48 samples. These results indicate that the novel ERGs of the present invention can be applied to gene expression in FFPE samples. geNorm and NormFinder analyses demonstrate that most of the novel ERGs are more stably expressed with lower Cp values in FFPE samples, as well as in the 48 samples, than are traditional ERGs (Table 9).







TABLE 6







Human tissues and cancer cell lines used in Real time-PCR













Tissue or cell

Normal (N)/




No.
lines
Type
Tumor (T)
Diagnosis
Remarks















1
Adrenal gland
frozen tissue
N
Normal



2
Brain
frozen tissue
N
Normal


3
Breast
frozen tissue
N
Normal


4
Colon
frozen tissue
N
Normal
Normal tissue adjacent to signet ring







cell carcinoma, ascending colon


5
Esophagus
frozen tissue
N
Normal


6
Kidney
frozen tissue
N
Normal


7
Liver
frozen tissue
N
Normal


8
Lung
frozen tissue
N
Normal


9
Omentum
frozen tissue
N
Normal


10
Ovary
frozen tissue
N
Normal


11
Placenta
frozen tissue
N
Normal


12
Placenta
frozen tissue
N
Normal
Immature placenta with focal







intervillous calcifications, normal two







umbilical arteries and one vein, and







no evidence of chorioamnionitis


13
Rectum
frozen tissue
N
Normal


14
Salivary gland
frozen tissue
N
Normal


15
Thyroid gland
frozen tissue
N
Normal


16
Tonsil
frozen tissue
N
Normal


17
Uterus
frozen tissue
N
Normal


18
Vein
frozen tissue
N
Normal


19
Vulva
frozen tissue
N
Normal


20
Brain
frozen tissue
T
Glioblastoma multiforme


21
Breast
frozen tissue
T
Invasive ductal carcinoma, upper






central


22
Transverse colon
frozen tissue
T
Ulcerofungating carcinoma,






transverse colon, Mucinous






adenocarcinoma


23
Lung
frozen tissue
T
Pleomorphic carcinoma


24
Ovary
frozen tissue
T
Transitional cell carcinoma, bilateral






ovaries


25
Rectum
frozen tissue
T
Adenocarcinoma, moderately






differentiated with mucin production


26
Stomach
frozen tissue
T
Advanced gastric carcinoma, Tubular






adenocarcinoma, M/D


27
HL-60
cell lines
T
Leukemia
Blood


28
MDA-MB-231
cell lines
T
Breast cancer
Breast


29
C33A
cell lines
T
Cervical cancer
Cervix


30
HeLa
cell lines
T
Cervical cancer


31
HCC-44
cell lines
T
Lung cancer
Lung


32
A549
cell lines
T
Lung cancer


33
Caov3
cell lines
T
Ovarian cancer
Ovary


34
OV-90
cell lines
T
Ovarian cancer


35
OVCAR3
cell lines
T
Ovarian cancer


36
SK-OV3
cell lines
T
Ovarian cancer


37
SNU119
cell lines
T
Ovarian cancer


38
SW626
cell lines
T
Ovarian cancer


39
AGS
cell lines
T
Gastric cancer
Stomach


40
Kato III
cell lines
T
Gastric cancer


41
MKN1
cell lines
T
Gastric cancer


42
MKN74
cell lines
T
Gastric cancer


43
NCI-N87
cell lines
T
Gastric cancer


44
SNU5
cell lines
T
Gastric cancer


45
SNU16
cell lines
T
Gastric cancer


46
SNU484
cell lines
T
Gastric cancer


47
SNU601
cell lines
T
Gastric cancer


48
SNU638
cell lines
T
Gastric cancer





*: Normal tissue adjacent to signet ring cell carcinoma, ascending colon; and


**: immature placenta with focal intervillous calcifications; normal two umbilical arteries and one vein, and no evidence of chorioamnionitis.













TABLE 7







Primers and Taqman Probes for Real-Time PCR










Gene
UPL
Primers
Product











Names
No.
Sense Primers
Anti-Sense Primers
(bp)





GAPDH
60
SEQ ID NO. 1:
SEQ ID NO. 2:
 66




agccacatcgctcagaca
gcccaatacgaccaaatcc



 


ACTB
64
SEQ ID NO. 3:
SEQ ID NO. 4:
 97




ccaaccgcgagaagatga
ccagaggcgtacagggatag



 


B2M
42
SEQ ID NO. 5:
SEQ ID NO. 6:
 86




ttctggcctggaggctatc
tcaggaaatttgactttccattc



 


PPIA
#
SEQ ID NO. 7:
SEQ ID NO. 8:
326




catctgcactgccaagactgag
tgcaatccagctaggcatg



 


HPRT1
73
SEQ ID NO. 9:
SEQ ID NO. 10:
102




tgaccttgatttattttgcatacc
cgagcaagacgttcagtcct



 


HMBS
26
SEQ ID NO. 11:
SEQ ID NO. 12:
 92




tgtggtgggaaccagctc
tgttgaggtttccccgaat



 


TBP
 3
SEQ ID NO. 13:
SEQ ID NO. 14:
 60




gctggcccatagtgatcttt
cttcacacgccaagaaacagt



 


H6PD
89
SEQ ID NO. 15:
SEQ ID NO. 16:
 74




tggagatcatcatgaaagagac
gcgaatgacaccgtactcct





c




 


ZNF207
27
SEQ ID NO. 17:
SEQ ID NO. 18:
 65




ctgtttcctagcacagcacaa
ggtttgaaatctgtaccaacagg



 


OAZ1
74
SEQ ID NO. 19:
SEQ ID NO. 20:
 67




caccatgccgctcctaag
gagggagaccctggaactct



 


LUC7L2
85
SEQ ID NO. 21:
SEQ ID NO. 22:
 60




cgatcacacagcaagaatcc
agatcgatgtctgcgatgc



 


CTBP1
77
SEQ ID NO. 23:
SEQ ID NO. 24:
 86




actgcgtgaccctgcact
gccccttgtctcatctgc



 


TRIM27
 7
SEQ ID NO. 25:
SEQ ID NO. 26:
 71




caggcacgagctgaactct
agctgctcaaactcccaaac



 


GPBP1
 4
SEQ ID NO. 27:
SEQ ID NO. 28:
 75




tcacttgaggcagaacacaga
agcacatgtttcatcattttcac



 


UBQLN
73
SEQ ID NO. 29:
SEQ ID NO. 30:
 92


1

gaatcctgaccttgctgcac
ttgggagctgttgtctcattt



 


ARL8B
82
SEQ ID NO. 31:
SEQ ID NO. 32:
 66




aagcatgtgggagcggtat
cgatctgcagcatctatcatgt



 


PAPOL
78
SEQ ID NO. 33:
SEQ ID NO. 34:
 91


A

gctacgaagaccagtccattg
tgttggtcacagatgctgct



 


CUL1
65
SEQ ID NO. 35:
SEQ ID NO. 36:
 86




gcgaggtcctcactcagc
ttctttctcaattagaatgtcaatgc



 


DIMT1L
77
SEQ ID NO. 37:
SEQ ID NO. 38:
 75




tccagtgttgtaaggatagaacc
Ccttactagaccatcccattcct





taag




 


FBXW2
 3
SEQ ID NO. 39:
SEQ ID NO. 40:
111




cggctctgcagacttcact
ttgcacttctgcaaaactacct



 


SPG21
21
SEQ ID NO. 41:
SEQ ID NO. 42:
 88




gatgtctttttccggcagat
cgagatggtcccaataaactg
















TABLE 8







PCR Efficiency of Genes











UPL Probe
PCR Efficiency
PCR Efficiency


Gene Name
Nos.
(Diluted)*
(LinRegPCR)**













GAPDH
60
1.899
1.735 ± 0.048 (137)


ACTB
64
2.038
1.491 ± 0.034 (137)


B2M
42
1.868
1.717 ± 0.068 (140)


PPIA
#
1.877
1.773 ± 0.058 (142)


HPRT1
73
1.800
1.771 ± 0.024 (143)


HMBS
26
1.954
1.431 ± 0.031 (143)


TBP
3
1.826
1.447 ± 0.038 (142)


H6PD
89
1.874
1.832 ± 0.026 (64)


ZNF207
27
1.869
1.648 ± 0.018 (142)


OAZ1
74
2.068
1.498 ± 0.059 (142)


LUC7L2
85
1.829
1.709 ± 0.047 (143)


CTBP1
77
2.064
1.651 ± 0.055 (141)


TRIM27
7
1.908
1.693 ± 0.034 (143)


GPBP1
4
1.844
1.715 ± 0.031 (141)


UBQLN1
73
1.864
1.723 ± 0.027 (143)


ARL8B
82
1.838
1.499 ± 0.074 (139)


PAPOLA
78
1.830
1.509 ± 0.032 (141)


CUL1
65
1.810
1.695 ± 0.027 (139)


DIMT1L
77
1.906
1.655 ± 0.037 (141)


FBXW2
3
1.891
1.638 ± 0.02 (142)


SPG21
21
1.826
1.636 ± 0.021 (142)





*PCR Efficiency; calculated with Roche Lightcycler software 4.0 using serial diluted cDNA of MKN 74 stomach cancer cell line;


**PCR Efficiency; calculated with LinRegPCR(Ramakers et al., Neurosci Lett 339(1): 62-66, 2003); and,


#: F-ttcttgctggtcttgccatTcctgga-p; T: TAMRA-labeled; F: FAM-labeled; P: phosphate.













TABLE 9







Expression Stability of Novel and Traditional ERGs Calculated by geNorm


and NormFinder based on Real-Time PCR Data








48 Samples
60 FFPE Samples*










GeNorm
NormFinder
GeNorm
NormFinder














Genes
M
Genes
S
Genes
M
Genes
S





GPBP1
0.496
TBP
0.276
GPBP1
0.409
ARL8B
0.233


CUL1

PAPOLA
0.280
PAPOLA

LUC7L2
0.235


PAPOLA
0.536
CUL1
0.287
ARL8B
0.437
OAZ1
0.247


TBP
0.548
LUC7L2
0.290
CTBP1
0.454
CTBP1
0.251


LUC7L2
0.565
CTBP1
0.312
LUC7L2
0.483
UBQLN1
0.273


TRIM27
0.585
GPBP1
0.317
SPG21
0.509
SPG21
0.280


FBXW2
0.597
TRIM27
0.317
FBXW2
0.528
FBXW2
0.286


CTBP1
0.608
FBXW2
0.329
OAZ1
0.545
PAPOLA
0.290


UBQLN1
0.623
DIMT1L
0.364
UBQLN1
0.555
TRIM27
0.327


DIMT1L
0.637
PPIA
0.383
TRIM27
0.567
GPBP1
0.345


PPIA
0.661
UBQLN1
0.398
TBP
0.580
HPRT1
0.368


OAZ1
0.682
OAZ1
0.438
CUL1
0.593
CUL1
0.383


ZNF207
0.709
ARL8B
0.494
HPRT1
0.609
TBP
0.402


ARL8B
0.731
SPG21
0.502
ZNF207
0.625
HMBS
0.407


SPG21
0.749
ZNF207
0.502
HMBS
0.641
ZNF207
0.440


HPRT1
0.770
HPRT1
0.516
GAPDH
0.668
PPIA
0.461


GAPDH
0.793
HMBS
0.587
PPIA
0.692
GAPDH
0.527


HMBS
0.815
GAPDH
0.591
B2M
0.715
B2M
0.530


ACTB
0.843
ACTB
0.618
ACTB
0.737
ACTB
0.541


B2M
0.888
B2M
0.815





*DIMT1L was excluded from the analysis.


M: mean expression stability calculated with geNorm program;


S: Stability calculated with NormFinder program.













TABLE 10







Correlation between CV in each dataset and expression stability calculated with geNorm and NormFinder

















EST-M
EST-S
ShortSAGE-M
ShortSAGE-S
LongSAGE-M
LongSAGE-S
Affy-M
Affy-S
M-S




















Pearson
0.676
0.792
0.659
0.75
0.427
0.561
0.039
0.017
0.953


P value
0.001
<0.001
0.002
<0.001
0.061
0.01
0.869
0.944
<0.001


Spearman
0.589
0.605
0.277
0.268
0.092
0.105
0.424
0.357
0.955


P value
0.006
0.005
0.237
0.254
0.701
0.661
0.063
0.123
<0.001


Pearson
0.623
0.626
0.656
0.737
0.481
0.672
0.243
0.335
0.852


P value
0.004
0.004
0.002
<0.001
0.037
0.002
0.317
0.161
<0.001


Spearman
0.663
0.596
0.515
0.502
0.374
0.567
0.521
0.583
0.841


P value
0.002
0.008
0.024
0.03
0.115
0.013
0.022
0.009
<0.001





M: Mean expression stability calculated with geNorm;


S: Stability calculated with NormFinder













TABLE 11







List of 567 Samples Including 13 Tissues in HG-U133 Array













Nos. of


Tissues
Categories
Morphology
Samples














Brain
Benign
Meningioma
7
23



Malignant
Glioblastoma Multiforme
7




Oligodendroglioma
6




Medulloblastoma
3


Breast
Normal
Normal Tissue
18
74



Malignant
Infiltrating Duct Carcionma
36




Infiltrating Duct and Lobular
7




Carcinoma




Infiltrating Lobular Carcinoma
13


Colon
Normal
Normal Tissue
22
62



Malignant
Adenocarcinoma
33




Mucinous Adenocarcinoma
7


Esophagus
Normal
Normal Tissue
11
17



Malignant
Adenocarcinoma
6


Kidney
Normal
Normal Tissue
26
51



Benign
Oncocytoma
5



Malignant
Clear Cell Adenocarcinoma
6




Renal Cell Carcinoma
14


Liver
Normal
Normal Tissue
10
29



Malignant
Hepatocellular Carcinoma
19


Lung
Normal
Normal Tissue
26
58



Malignant
Adenocarcinoma
15




Squamous Cell Carcinoma
17


Lymph
Normal
Normal Tissue
4
23


Node
Malignant
Hodgkin's Disease
4




Malignant Lymphoma
15


Ovary
Normal
Normal Tissue
10
50



Malignant
Adenocarcinoma
5




Clear Cell Adenocarcinoma
6




Mucinous Cystadenocarcinoma
5




Serous Cystadenocarcinoma
6




Papillary Serous Adenocarcinoma
18


Pancreas
Normal
Normal Tissue
13
41



Malignant
Adenocarcinoma
28


Prostate
Normal
Normal Tissue
14
41



Malignant
Adenocarcinoma
27


Rectum
Normal
Normal Tissue
17
38



Malignant
Adenocarcinoma
21


Stomach
Normal
Normal Tissue
17
60



Malignant
Adenocarcinoma
37




Signet Ring Cell Carcinoma
6



Total



567

## Claims

1. A method for quantifying an expression level of a target gene, comprising:
1) synthesizing cDNA from RNA of a subject;
2) performing real-time PCR to amplify the target gene using a pair of primers and/or probes with the cDNA serving as a template and then performing real-time PCR to amplify an endogenous reference gene, wherein said endogenous reference gene is selected by a method comprising (a) computing expression levels of genes from EST (expressed sequence tag), SAGE (serial analysis of gene expression), and microarray datasets; and (b) identifying constitutively expressed genes from more than one tissue type based on the computed gene expression levels of step (a) and zero(0)'s proportions thereof; and
3) normalizing an expression level of the target gene to that of the endogenous reference gene of step 2).

2. A method for quantifying an expression level of a target gene, comprising:
1) synthesizing cDNA from RNA of a subject;
2) performing real-time PCR to amplify the target gene using a pair of primers and/or probes with the cDNA serving as a template and then performing real-time PCR to amplify an endogenous reference gene, wherein said endogenous reference gene is selected by a method comprising (a) computing expression levels of genes from EST (expressed sequence tag), SAGE (serial analysis of gene expression), and microarray datasets; (b) identifying constitutively expressed genes from more than one tissue type based on the computed gene expression levels of step (a) and zero(0)'s proportions thereof; (c) determining the coefficient of variation (CV) for the endogenous reference gene; and (d) ranking the endogenous reference gene in an ascending order of CV; and
3) normalizing an expression level of the target gene to that of the endogenous reference gene of step 2).