Initial to indicate certification as to information on this page (full text of certification is on page one) 

13. Phone Number

10. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any 

knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law.

12. Name of Company

11. Date

OMB Approval 2070-0174 

EPA FORM 6300-3

United States Environmental Protection Agency 

Washington, D.C. 20460

REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE

INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline

Requirement

Number

5. Study Title Progress 

Reports

1 2 3

6. Use 

Pattern

7. Test 

Substance

8. Time

Frame 

(Months)

9. Registrant

Response

P

R

O

T

O

C

O

L

1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Signature and Title of Company's Authorized Representative _________________________________________________________________

LANXESS CORPORATION

111 RIDC PARK WEST DRIVE

PITTSBURGH, PA 152751112

Applicator Exposure Data Requirements (Conventional 

Chemical)

Post-Application Exposure Data Requirements (Conventional 

Chemical)

Terrestrial and Aquatic Nontarget Organisms Data 

Requirements (Conventional Chemical)

875.1200

875.1400

875.1700

875.2700

875.2300

875.2800

850.2100

Dermal exposure--Indoor

Inhalation exposure--indoor

Product Use Information

Product Use Information

Indoor surface residue dissipation

Description of human activity

Avian acute oral toxicity test

2670 - Thiabendazole

Chemical # and Name: 060101

Thiabendazole

22-Jul-2015

GENERIC

ID # GDCI-060101-1453

X,C,A

X,C,A

X,C,A

X,C,A

X,C,A

X,C,A

X,C,A

TEP

TEP

TEP

TEP

TEP

TEP

TGAI

12

24

12

12

24

12

12

Page 1 of 

(10, 16, 20)

(10, 16, 20)

(10)

(10)

(9, 10, 21)

(10)

N

N

N

N

Y

N

N

3
OMB Approval 2070-0174 

EPA FORM 6300-3

United States Environmental Protection Agency 

Washington, D.C. 20460

REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE

INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline

Requirement

Number

5. Study Title Progress 

Reports

1 2 3

6. Use 

Pattern

7. Test 

Substance

8. Time

Frame 

(Months)

9. Registrant

Response

P

R

O

T

O

C

O

L

1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

LANXESS CORPORATION

111 RIDC PARK WEST DRIVE

PITTSBURGH, PA 152751112

835.3110

835.3220

835.3240

835.3280

850.3040

850.3300

850.4500

850.4550

850.6100

Ready biodegradability

Porous pot test

Simulation Test-Aerobic Sewage Treatment-Activated

Sludge

Simulation Tests to Assess the Biodegradability of 

Chemicals

Field testing for pollinators

Modified Activated Sludge, Respiration Inhibition Test

Algal Toxicity

Cyanobacteria (Anabaena flos-aquae) Toxicity

Environmental Chemistry Methods and Associated 

Independent Laboratory Validation

2670 - Thiabendazole

Chemical # and Name: 060101

Thiabendazole

22-Jul-2015

GENERIC

ID # GDCI-060101-1453

X,C,A

X,C,A

X,C,A

X,C,A

X,C,A

X,C,A

X,C,A

X,C,A

X,C,A

TGAI

TGAI

TGAI

TGAI

TEP

TGAI

TGAI

TGAI

TGAI

12

12

12

12

24

12

12

12

12

Page 2 of 

(1, 10, 19)

(1, 10, 19)

(1, 10, 19)

(1, 10, 19)

(4, 7, 21)

(1, 10)

(8)

(8)

(18)

N

N

N

N

Y

N

N

N

N

3
Date

OMB Approval 2070-0174 

EPA FORM 6300-3

United States Environmental Protection Agency 

Washington, D.C. 20460

REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE

INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline

Requirement

Number

5. Study Title Progress 

Reports

1 2 3

6. Use 

Pattern

7. Test 

Substance

8. Time

Frame 

(Months)

9. Registrant

Response

P

R

O

T

O

C

O

L

1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

LANXESS CORPORATION

111 RIDC PARK WEST DRIVE

PITTSBURGH, PA 152751112

SS-1154

SS-1254

SS-1256

SS-1314

SS-1316

SS-1319

Acute honey bee larvae feeding study

Adult honeybee chronic oral toxicity

Acute oral toxicity--honeybee adult

Honey bee larvae chronic oral toxicity

Field trial of residues in pollen and nectar

Semi-field testing for pollinators (tunnel or colony 

feeding studies)

2670 - Thiabendazole

Chemical # and Name: 060101

Thiabendazole

22-Jul-2015

GENERIC

ID # GDCI-060101-1453

X,C,A

X,C,A

X,C,A

X,C,A

X,C,A

X,C,A

TGAI

TGAI

TGAI

TGAI

TEP

TEP

12

12

12

12

24

24

Page 3 of 

(13, 21)

(11, 21)

(6, 21)

(12, 14, 21)

(2, 5, 21)

(3, 15, 17, 

21)

Y

Y

Y

Y

Y

Y

3
United States Environmental Protection Agency 

Washington, D.C. 20460

FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS

2670 - Thiabendazole

GDCI-060101-1453

1

2

3

4

5

6

7

8

Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active 

Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

The results of the Activated Sludge, Respiration Inhibition Test (ASRI), GLN 850.3300, will determine which of the four biodegredation tests is/are required. If the ASRI test results in an EC50 of 

less than or equal to 20 mg/L, then the registrant is required to conduct either the (i) Simulation tests to assess the biodegradability of chemicals discharged in wastewater1, GLN 835.3280, (ii) 

the Simulation Test Aerobic Sewage Treatment A. Activated Sludge Units, GLN 835.3240, or (iii) the Porous Pot Test, GLN 835.3220. If the ASRI test results in an EC50 greater than 20 mg/L, then

the registrant would be required to conduct either the (i) Ready Biodegradability, GLN 3110, (ii) Simulation tests to assess the biodegradability of chemicals discharged in wastewater, (iii) the 

Simulation Test Aerobic Sewage Treatment A. Activated Sludge Units, or (iv) the Porous Pot Test. If the Ready Biodegradability Study is conducted and passes, then no further testing is 

required. If, however, the pesticide fails the Ready Biodegradability study, then the registrant is required to conduct either the (i) Simulation tests to assess the biodegradability of chemicals 

discharged in wastewater, (ii) the Simulation Test Aerobic Sewage Treatment A. Activated Sludge Units, or (iii) the Porous Pot Test.

The need for measures of residues in pollen/nectar will be determined based upon lower tiered tests and/or other lines of evidence, and the need for a refined pollinator risk assessment.

The need for a semi-field test for pollinators (i.e., either a field-feeding test or a tunnel test) will be determined based upon the results of lower-tiered tests and/or other lines of evidence, and the

need for a refined pollinator risk assessment.

The need for a field test for pollinators will be determined based upon lower-tiered tests and/or other lines of data and the need for a refined pollinator risk assessment.

The following elements should be considered when developing study protocol(s) for the monitoring of residues in pollen/nectar.

(1) Consideration of the range of application methods and environmental conditions (e.g., soil and hydric regimes) that the target crop(s) may be under.

(2) Consideration of the attractiveness of the selected crop to pollinators

(3) Consideration of a collection schedule sufficient to allow for an understanding of the character of residues, in the pollen/nectar and/or plant tissues, over time.

(4) Consideration of data sufficient to determine whether residues of the active ingredient and/or degradation product(s) accumulates in soil and is/are bioavailable for plant to uptake in a 

following planting, and therefore result in potential exposure to pollinators.

(5) Consideration of the market proportion of the selected target crop(s).

See the OECD 213: OECD Guidelines for the Testing of Chemicals. Honeybees, Acute Oral Toxicity Test. 213. http://www.oecd-ilibrary.org/environment/test-no-213-honeybees-acute-oraltoxicity-test_9789264070165-en

See information and guidance identified in the EPA documents, (i) USEPA. 2012. White Paper in Support of the Proposed Risk Assessment Process for Bees. Submitted to the FIFRA Scientific 

Advisory Panel for Review and Comment September 11 - 14, 2012. Office of Chemical Safety and Pollution Prevention, Office of Pesticide Programs Environmental Fate and Effects Division, 

Environmentally Protection Agency, Washington, DC; Environmental Assessment Directorate, Pest Management Regulatory Agency, California Department of Pesticide Regulation. June 19, 2014. 

http://www2.epa.gov/sites/production/files/2014-06/documents/pollinator_risk_assessment_guidance_06_19_14.pdf and USEPA. 2012c. "Field Testing for Pollinators." Ecological Effects Test 

Guidance OCSPP 850.3030. EPA 712-C-017. Web. http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPPT-2009-0154-0018.

Results for studies conducted for (i) the freshwater green alga, Selenastrum capricornutum, (ii) the freshwater diatom, Navicula pelliculosa, (iii) the marine diatom, Skeletonema costatum, and 

(iv) the cyanobacteria species Anabaena flos-aquae, must be submitted to satisfy this requirement. Final 850 guidelines for the algal testing were posted in June 2012. The Public Draft OPPTS 

850.5400 Algal Toxicity guideline was split into two separate guidelines and renumbered with the cyanobacteria species separated into OCSPP 850.4550 and the other three species under 

OCSPP 850.4500.

Case # and Name:

DCI Number:

Page: 1 of

Footnotes: The following footnotes are referenced in column two (5. Study Title) of the Requirements Status and Registrant's Response form. 

These footnotes apply in addition to any test notes included in 40 CFR Part 158 with respect to the particular data requirement.

Use Categories Key:

A - Terrestrial food crop

C - Terrestrial nonfood crop

X - Materials preservatives

2
United States Environmental Protection Agency 

Washington, D.C. 20460

FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS

2670 - Thiabendazole

GDCI-060101-1453

9

10

11

12

13

14

15

16

17

18

19

20

21

Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active 

Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

Residue dissipation studies are required for textiles (clothing) and the plush of carpets. If specified on the label that only carpet backing is treated, then a residue study will not be needed for 

carpets.

Required only from registrants with registrations for antimicrobial use.

OECD has not yet finalized test guidelines for chronic studies, and efforts are underway to develop standardized guidelines for assessing the effects from chronic exposure to adult and larvae 

in the laboratory. Discussion of the study design elements for the 10-day adult toxicity test can be found in Appendix O of the European Food Safety Authority (EFSA) guidance document: 

EFSA. Guidance on the risk assessment of plant protection products on bees (Apis mellifera, Bombus spp. and solitary bees. EFSA Journal 2013;11(7):3295, 266 pp. 

doi:10.2903/j.efsa.2013.3295. 

Available online at: http://www.efsa.europa.eu/en/efsajournal/doc/3295.pdf

OECD has not yet finalized test guidelines for chronic studies with honey bee larvae. OECD draft guidance is being developed, see OECD Draft Guidance Document Honey Bee (Apis mellifera) 

Larval Toxicity Test, Repeated Exposure, http://www.oecd.org/env/ehs/testing/Draft_GD_honeybees_rep_exp_for_2nd_CR_25_November_2013.pdf

OECD Test Guideline 237 may be used to develop a protocol for this study (OECD. 2013 Guidelines for Testing Chemicals. Honey bee (Apis mellifera) larval toxicity test, single exposure.) See: 

http://www.oecd-ilibrary.org/environment/test-no-237-honey-bee-apis-mellifera-larval-toxicity-test-single-exposure_9789264203723-en.

In some cases, information pertaining to acute toxicity to honey bee larvae may be obtained with the chronic honey bee larvae test thereby negating the need for separate acute and chronic 

larval toxicity tests.

Formal guidelines for semi-field tests do not yet exist; however, information that can help guide the development of either a semi-field tunnel test protocol can be found at OECD 75, see: OECD. 

2007. Series on Testing and Assessment Number 75. Guidance document on the honey bee (Apis mellifera L.) brood test under semi-field conditions. Environmental Directorate Joint Meeting of 

the Chemicals Committee and the Working Party on Chemicals, Pesticides and Biotechnology. ENV/JM/MONO(2007)22. August 31, 2007. 

http://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=env/jm/mono(2007)22&doclanguage=en.

For products with both indoor and outdoor uses, and similar conditions of use, data are generally required for the indoor applications only. However, data for outdoor uses are required if the 

Agency expects outdoor uses to result in greater exposure than indoor uses (e.g., higher use rates and application, frequency, or longer exposure duration, or application methods/equipment) 

create potential for increased dermal or inhalation exposure in outdoor versus indoor use sites). In certain cases, when a pesticide may be used both indoors and outdoors under dissimilar 

conditions of use, the Agency may require submission of applicator exposure data for both use patterns.

For field-feeding studies see the following: Oomen et al. 1992: Oomen, P. A. A. DeRuijter and J. Van der Steen. 1992. Method for honey bee brood feeding tests with insect growth-regulating 

insecticides. Bul OEPP/EPPO Bulletin 22: 613-616.

Environmental chemistry analytical methods and associated laboratory validations for water only.

EPA has a published final guideline for this study: http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPPT-2009-0152. The required biodegradation study is based on the results of an 

Activated Sludge Respiration Inhibition test.

Airless sprayer and brush/roller.

A study protocol must be submitted to, and reviewed by EPA, prior to study initiation.

Case # and Name:

DCI Number:

Page: 2 of 2