|   | Re: | Amendment      to Extension and Amendment to Budget and Research Agreement between      Waterloo, Thompson, and Senesco for a Nine Month Period From December 1,      2010 Through August 31, 2011 |
|--------|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| Very      truly yours, |
|------------------------|
|                   |
| Leslie      J. Browne  |
| President              |
| Senesco,      Inc.     |

| Agreed      and Accepted:     |   |
|-------------------------------|--------|
|                          |   |
|                          |   |
| University      of Waterloo   |   |
|                          |   |
|                          |   |
| Dr.      John Thompson, Ph.D. |   |

----

| Salaries                           |   | Cdn $/Month |      |   | Cdn $/3 Months |   |
|------------------------------------|--------|-------------|-----------|--------|----------------|--------|
|                               |   |        |      |   |           |   |
| Senior      Research Associate     |   | $           | 8,625.00  |   |           | $      | 25,875.00 |   |
| ($90,000/year      + 15% benefits) |   |        |      |   |           |   |   |   |
|                               |   |        |      |   |           |   |   |   |
| Senior      Research Associate     |   |        | 6,708.33  |   |           |   | 20,125.00 |   |
| ($70,000/year      + 15% benefits) |   |        |      |   |           |   |   |   |
|                               |   |        |      |   |           |   |   |   |
| Research      Associate            |   |        | 4,791.67  |   |           |   | 14,375.00 |   |
| ($50,000/year      + 15% benefits) |   |        |      |   |           |   |   |   |
|                               |   |        |      |   |           |   |   |   |
| Research      Associate            |   |        | 4,791.67  |   |           |   | 14,375.00 |   |
| ($50,000/year      + 15% benefits) |   |        |      |   |           |   |   |   |
|                               |   |        |      |   |           |   |   |   |
| Research      Associate            |   |        | 3,833.33  |   |           |   | 11,500.00 |   |
| ($40,000/year      + 15% benefits) |   |        |      |   |           |   |   |   |
|                               |   |        |      |   |           |   |   |   |
| Research      Associate            |   |        | 1,916.67  |   |           |   | 5,750.00 |   |
| ($20,000/year      + 15% benefits) |   |        |      |   |           |   |   |   |
|                               |   |        |      |   |           |   |   |   |
| Research      Associate            |   |        | 1,916.67  |   |           |   | 5,750.00 |   |
| ($20,000/year      + 15% benefits) |   |        |      |   |           |   |   |   |
|                               |   |        |      |   |           |   |   |   |
| Supplies                           |   |        |      |   |           |   |   |   |
| Operating      Expenses            |   |        | 10,000.00 |   |           |   | 30,000.00 |   |
|                               |   |        |      |   |           |   |   |   |
| Subtotal                           |   |        | 42,583.34 |   |           |   | 127,750.00 |   |
|                               |   |        |      |   |           |   |   |   |
| Overhead                           |   |        |      |   |           |   |   |   |
| 30%      on total direct costs     |   |        | 12,775.00 |   |           |   | 38,325.00 |   |
|                               |   |        |      |   |           |   |   |   |
| TOTAL      BUDGET                  |   | $           | 55,358.34 |   |           | $      | 166,075.00 |   |

----

| Salaries                           |   | Cdn $/Month |      |   | Cdn $/6 Months |   |
|------------------------------------|--------|-------------|-----------|--------|----------------|--------|
|                               |   |        |      |   |           |   |
| Senior      Research Associate     |   | $           | 8,625.00  |   |           | $      | 51,750.00 |   |
| ($90,000/year      + 15% benefits) |   |        |      |   |           |   |   |   |
|                               |   |        |      |   |           |   |   |   |
| Senior      Research Associate     |   |        | 2,395.83  |   |           |   | 14,375.00 |   |
| ($25,000/year      + 15% benefits) |   |        |      |   |           |   |   |   |
|                               |   |        |      |   |           |   |   |   |
| Research      Associate            |   |        | 4,791.67  |   |           |   | 28,750.00 |   |
| ($50,000/year      + 15% benefits) |   |        |      |   |           |   |   |   |
|                               |   |        |      |   |           |   |   |   |
| Research      Associate            |   |        | 4,791.67  |   |           |   | 28,750.00 |   |
| ($50,000/year      + 15% benefits) |   |        |      |   |           |   |   |   |
|                               |   |        |      |   |           |   |   |   |
| Research      Associate            |   |        | 3,833.33  |   |           |   | 23,000.00 |   |
| ($40,000/year      + 15% benefits) |   |        |      |   |           |   |   |   |
|                               |   |        |      |   |           |   |   |   |
| Supplies                           |   |        |      |   |           |   |   |   |
| Operating      Expenses            |   |        | 10,000.00 |   |           |   | 60,000.00 |   |
|                               |   |        |      |   |           |   |   |   |
| Subtotal                           |   |        | 34,437.50 |   |           |   | 206,625.00 |   |
|                               |   |        |      |   |           |   |   |   |
| Overhead                           |   |        |      |   |           |   |   |   |
| 30%      on total direct costs     |   |        | 10,331.25 |   |           |   | 61,987.50 |   |
|                               |   |        |      |   |           |   |   |   |
| TOTAL      BUDGET                  |   | $           | 44,768,75 |   |           | $      | 268,612.50 |   |

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