1 Summary Minutes of the

U.S. Environmental Protection Agency (EPA)

Clean Air Scientific Advisory Committee (CASAC)

Lead Review Panel

Public Teleconference

Ma y 30 , 2012

Date and Time : Wednes day

, Ma y 30 , 2012

, 12 :0 0 P M

– 3 :00 PM ET

Location : Teleconfer ence Only

Purpose : The purpose of the meeting was t o discuss the CASAC Lead Review Panel’s

05

- 16

- 12 Draft Review of the EPA’s Integrated Science Assessment (ISA) for

Lead (Second External Review Draft

– February 2012)

Participants : Lead Review Panel (for full roster, see Attachment A)

Dr. H. Christopher Frey , Chair

Mr. George Allen

Dr. Herbert Allen

Dr. Richard Canfield

Dr. Cliff Davidson

Dr. Sean Hays

Dr. Susan Korrick

Dr. Michael Kosnett

Dr. Roman Lanno

Mr. Richard Poirot

Dr. Joel Pounds

Dr. Michael Rab inowitz

Dr. William Stubblefield

Dr. Ian von Lindern

Dr. Gail Wasserman

Mr. Aaron Yeow, Designated Federal Officer (DFO)

Wednes day, Ma y 30 , 2012

Opening Remarks

Mr

. Aaron Yeow , the DFO for the CASAC Lead Review Panel took roll and opened the

meetin g

. H e noted that as required under the Federal Advisory Committee Act (FACA) , the

Panel ’s deliberations are held in public with advanced notice given in the Federal Register 1 , and

the meeting minutes will be made publicly available after the meeting. H e no ted that the re was

one registered public speaker and a copy of the oral statement was available on the meeting

webpage

. H e also no ted that t he SAB Staff Office determined that there we re no issues with2

conflict

- of

- interest or appearance of a lack of impart iality for any of the advisory panel members

participating in th e review

. He t hen turned the meeting over to Dr. Chris Frey

, Chair of the

C ASAC Lead Review Panel

.

Dr. Frey welcomed everyone

, st ated the purpose of the teleconference was to review the Panel ’s

draft review of EPA’s 2 nd Draft Lead ISA, and reviewed the Agenda 2

.

Public Comment s

Stephanie Shirley, Texas Commission on Environmental Quality, presented her oral statement 3

and stated that the draft ISA frequently confuses associations with causat ions. She stated that the

discussion of lead exposure and IQ did not adequately address uncertainties and confounders.

Lastly she stated that inhalation of Pb is a minor exposure pathway compared to other exposure

pathways. One panel member asked her which confounders in the Pb

- IQ literature she found

were not addressed. She indicated it was mainly paternal IQ, which another panel member stated

was addressed in some of her studies.

Discussion of Consensus Responses

The Panel proceeded through the Consensu s Responses . There was some discussion on how to

clarify the statement in the response to the Chapter 1 charge question on the reversibility of

health effects. For the response to Chapter 3 charge questions, there was some discussion on Pb

wheel weights an d it was agreed to add a sentence stating that EPA should review a particular

recent study on Pb wheel weights. For the response to the Chapter 5 charge questions, there was

some discussion on refining the comment regarding the need for utilizing experts i n

psychometric assessment as well as clarifying the comment on short duration exposures. For the

response to the Chapter 6 charge questions, there was discussion of adding a bullet regarding the

potential susceptibility of African Americans to lead possibl y arising from factors not mediated

by SES or exposure. There was also discussion about adding a statement that the discussion of

the effect of fluoridation on lead exposure in the Integrative Summary was not supported by the

literature and should be remov ed.

Discussion of Letter to Administrator

The Panel proceeded through the Letter to the Administrator with recommendations to improve

the clarity and had some discussion on the need for an overarching comment that states that the

ISA presents the discuss ion of many studies in an encyclopedic fashion, lacking an integrative

synthesis.

The Panel and the members of CASAC were satisfied with the letter/report with the changes

discussed and did not have any further comments.

With business conclude d

, the meet in g was adjourned by the DFO at 2 : 1 5 p m.3

Respectfully Submitted: Certified as Accurate :

/SIGNED/ /SIGNED/

Mr. Aaron Yeow Dr. H. Christopher Frey

Designated Federal Officer Chair

EPA SAB Staff Office CASA C Lead Review Pan el

NOTE AND DISCLAIMER: The minutes of this public meeting reflect diverse ideas and

suggestions offered by Panel members during the course of delib erations within the meeting. Such

ideas, suggestions and deliberations do not necessarily reflect consens us advice from the Panel

members. The reader is cautioned to not rely on the minutes to represent final, approved, consensus

advice and recommendatio ns offered to the Agency. Such advice and recommendations may be

found in the final advisories, commentarie s, letters or reports prepared and transmitted to the EPA

Administrator following the public meetings.4

Materials Cited

The following meeting materials are available on the CASAC website:

http://www.epa.gov/casac , at the May 30, 2012 CASAC Lead Review Panel Meeting page :

1 Federal Register Notice Announcing the Meeting

2 Agenda for Ma y 30 , 201 2 Public Meeting

3 Oral Statement from Stephanie Shirley, Texas Commis sion on Environmental QualityA

- 1 ATTACHMENT A

- ROSTER



### U.S. Environmental Protection Agency

Clean Air Scientific Ad visory Committee

CASAC Lead Review Panel

CHAIR

Dr. H. Christopher Frey , Professor, Department of Civil, Construction and Environmental

Engineering, College of Engineering, North Carolina State University, Raleigh, NC

CASAC MEMBER

Mr. George A. Allen

, Senior Scientist, Northeast States for Coordinated Air Use Management

(NESCAUM), Boston, MA

CONSULTANTS

Dr. Herbert Allen , Professor Emeritus, Department of Civil and Environmental Engineering,

University of Delaware, Newark, DE

Dr. Richard Canfield , Se nior Research Associate, Division of Nutritional Sciences, Cornell

University, Ithaca, NY

Dr. Deborah Cory

- Slechta , Professor, Department of Environmental Medicine, School of

Medicine and Dentistry, University of Rochester, Rochester, NY

Dr. Cliff Davids on , Professor, Civil and Environmental Engineering, Syracuse University,

Syracuse, NY

Dr. Philip E. Goodrum , Senior Consultant, Cardno ENTRIX, Syracuse, NY

Dr. Sean Hays , President, Summit Toxicology, Allenspark, CO

Dr. Philip Hopke , Bayard D. Clarkson Distinguished Professor, Department of Chemical and

Biomolecular Engineering, Clarkson University, Potsdam, NY

Dr. Chris Johnson , Professor, Department of Civil and Environmental Engineering, Syracuse

University, Syracuse, NY

Dr. Susan Korrick , Assistant Professor of Medicine , Department of Medicine, Brigham and

Women's Hospital, Channing Laboratory, Harvard Medical School, Boston, MAA

- 2

Dr. Michael Kosnett , Associate Clinical Professor, Division of Clinical Pharmacology and

Toxicology, Department of Medi cine, University of Colorado School of Medicine, Denver, CO

Dr. Roman Lanno , Associate Professor and Associate Chair, Department of Evolution,

Ecology, and Organismal Biology, Ohio State University, Columbus, OH

Mr. Richard L. Poirot , Environmental Analy st, Air Pollution Control Division, Department of

Environmental Conservation, Vermont Agency of Natural Resources, Waterbury, VT

Dr. Joel G. Pounds , Laboratory Fellow, Cell Biology & Biochemistry, Biological Sciences

Division, Pacific Northwest National L aboratory, Richland, WA

Dr. Michael Rabinowitz , Geochemist, Marine Biological Laboratory, Newport, RI

Dr. William Stubblefield , Senior Research Professor, Department of Molecular and

Environmental Toxicology, Oregon State University, Corvallis, OR

Dr. I an von Lindern , President, TerraGraphics Environmental Engineering, Inc., Moscow, ID

Dr. Gail Wasserman , Professor of Clinical Psychology in Child Psychiatry, Division of Child

and Adolescent Psychiatry, College of Physicians and Surgeons, Columbia Univer sity, New

York, NY

Dr. Michael Weitzman , Professor, Pediatrics; Psychiatry, New York University School of

Medicine, New York, NY

SCIENCE ADVISORY BOARD STAFF

Mr. Aaron Yeow , Designated Federal Officer, U.S. Environmental Protection Agency, Science

Advi sory Board,Washington, DCB

- 1 ATTACHMENT B

– Other Attendees

CASAC Lead Review Panel Public Teleconference

(Persons who requested the teleconference call

- in number or indicated they were on the call)

Ma y 30

, 201 2

Name Affliation

Brown, James EPA

De itrich, Casey FDCH

Dubois, Jean Jacques EPA

Hopkinson, Jenny InsideEPA

Hoyer, Marion EPA

Jacobs, Jeremy Greenwire

Kirrane, Ellen EPA

Kotchmar, Dennis EPA

Lassiter, Meredith EPA

Murphy, Deirdre EPA

Nystrom, Marci California Air Resources Board

Orl in, David EPA

Owens, Elizabeth EPA

Patel, Molini EPA

Richmond

- Bryant, Jennifer EPA

Ross, Mary EPA

Shirley, Stephanie Texas Commission on Environmental Quality

Stanek, Lindsay EPA

Tennant, Ginger EPA

Vinikoor

- Imler, Lisa EPA

Walsh, Debra EPA

Wilso n, Linda NYS Office of the Attorney General