### Page 3 of 8

from registrants, other federal and state health and environmental agencies

, an d individual consumers. Since 1992, OPP has compile d these reports in IDS. IDS contain s reports from across the U.S. and most incidents have all relevant product information recorded. Reports submitted to the IDS represent anecdotal reports or allegations only, unless otherwise stated in the report.

IDS records incidents in one of two modules: Main IDS and Aggregate IDS:

o Main IDS contains incidents resulting in higher severity outcomes and provides more detail with regard to case specific s . This system stores incident data for death, major and moderate incidents, and it includes information about the location, date and nature of the incident. Main IDS incidents involving only one pesticide are considered to provide more certain informatio n about the potential effects of exposure from the pesticide.

o Aggregate IDS contains incidents resulting in less severe human incidents (minor, unknown, or no effects outcomes) . These are reported by registrants only as counts in what are aggregate summa ries

.

For the M ain IDS, from January 1, 200 7 to September 13, 2012, there were 10 incidents reported for single chemical only in the database and 17 additional incidents reported involving more than one chemical. These incidents all occurred to adult ho meowner applicators. They experienced respiratory, dermal, ocular, and neurological symptoms. These incidents were classified as modera te severity and are described further in Table 1. Overall, there are few incidents involving metheanearsonic acid, salts reported to IDS.

In A ggregate IDS , from January 1, 200 7 to September 13 , 2012

, there were 1 22 reported incidents involving metheanearsonic acid, salts

.

b. NIOSH SENSOR

The NIOSH

- led SENSOR

- Pesticides database covers 11 states from 1998

- 2008, although reporting varies from state to state. Cases of pesticide

- related illnesses are ascertained from a variety of sources, including: reports from local Poison Control Centers, state Department of Labor workers’ compen sation claims when reported by physicians, reports from Stat e Departments of Agriculture, and physician reports to s tate Departments of Health . Although both occupational and non

- occupational incidents are included in the database, SENSOR

- Pesticides focuse s on occupational pesticide incidents, and is of particular value in providing that information. A state SENSOR contact specialist attempts to follow

- up with cases and obtains medical records to verify symptoms, circumstances surrounding the exposure, seve rity, and outcome. Using standardized protocol and case definitions, derived from poison center reporting, SENSOR

- Pesticides coordinators at State Departments of Health enter the incident interview description provided by the case , medical report, physici an into the data system

. In order to be included in the database, all SENSOR

- Pesticides cases, including low severity cases, must have at least two adverse health effects.

### Page 4 of 8

In SENSOR

- Pesticides from 1998

- 2008, 29 individual cases, stemming from 26 events, were identified. Methanearsonic acid was the single AI implicated in 17 of these cases. Three cases of the 29 cases are classified as high severity, six are moderate in severity and 20 are low in severity. Eight cases are classified as work

- related and a review of narrative and details affirms all were occupational, resulting from pesticide applications

. Table 2 provides a summary of symptoms reported for all cases. Cases may report multiple symptoms.

Table 2 . Reported Symptom by Cases Exposed to Metheanearsonic acid, salts

MSMA was the product implicated in two (of three) high severity incidents. One high severity incident involved what the physician suspected to be a potentially malicious poisoning by a certified pesticide applicator. Descriptions for the three high severity incidents are pro vided in the Table 3 below.

Nine cases involve d children (ranging from ages 2 through 17) with symptomatic exposures. In one multiple exposure event that occurred in Florida in 2006, four school children (11

- 12 years old) were playing in a park and all l aid in grass that was stained blue from an MSMA (EPA r eg # 00060303511) application. 1 

### All four children experienced dizziness and weakness. Two of the children also experienced shortness of breath and sore throats. Three of these four children were
trea ted at an ER and one did not seek medical treatment. Three of these four cases were low in severity and one case was moderate.

Another exposure event involved two 11

- year

- old school children who both sat in an area at school that had been sprayed with A cme Crabgrass and Nutgrass Killer (single active ingredient) on the previous day. These two cases went to the ER and both reported headache and dizziness and are classified as low in severity.

Another case involved a two

- year old that sprayed Herbicide 3D RTU (contains multiple active ingredients) on his face, lips and in his eye. This was a low severity case. Another child case occurred when the 9

- year

- old drank from a glass he thought contained water but was actually Weed Be Gone. This case went to the ER and reported vomiting, nausea, and diarrhea; this case is cla ssified as moderate in severity. In another case involved a 15

- year

- old who rolled in grass that was sprayed with Image Herbicide and developed hives and itching and was seen by a physic ian. This case was low in severity. The final child case involved a 17

- year

- old but no narrative or details were provided for this case that was lost to follow

- up.

1 OPPIN query of registration # 603

- 3511 shows this product was cancelled in 1987. 

### System Effected Number of Cases Nervous System 16 Gastrointestinal 13 Eye 6 Respiratory 9 Dermal 9 Cardiovascular 1 Renal 1 Misc. 5

### Page 5 of 8 c. AHS

The AHS is a high quality

, prospective epidemiology study evaluating the link between pesticide use and various health outcomes including cancer. The AHS includes private and commercial pesticide applicators and their spouses . If there are AHS findings relevant to a particular pesticide going through registration review, the Agency will ensure they are considered in the problem formulation/scoping phase of the process and, if appropriate, fully reviewed in the risk assessment phase of the process

. The AHS includes information on use of 50 different pesticide active ingredients common ly used in agriculture.

Metheanearsonic acid, salts are not included in the AHS, and therefore this study does not provide information for this report.

IV. CONCLUSION

Based on the low frequency and mostly low severity of incident cases reported for metheanearsonic acid, salts in both IDS and NIOSH SENSOR, there does not appear to be a concern at this time that would warrant further investigation. However; because there were three incidents in NIOSH SENSOR classified as high severity, the Agency will continue to monitor the incident information and if a concern is triggered, additional analysis will be included in the risk assessment.

### Page 6 of 8

Table 1 : IDS Incidents involving the single chemical Metheanearsonic acid, salts

Human Incident Chemical: Metheanearsonic acid, salts PC Codes: 035301, 035302, 035303, 128920

Incident Package Report Incident

Date Location Reg Number Product Name Ingredient Name Exposure

Severity * Incident Description

018507

- 00042 4/16/2007 SLAINSVILLE, WV 000239

-

02572 WEED

- B

- GON

CRABGRASS KILLER (READY

- TO

- USE TRIGGER SPRAY) MSMA,

calcium salt HC An adult male applied the product. He developed a sore throat that persisted for two weeks. He saw his MD who diagnosed a pollen allergy and prescribed antihistamine.

018818

- 00006 6/27/2007 SACRAMENTO, CA 000239

-

02510 WEED

- B

- GON

CRABGRASS KILLER CONCENTRATE MSMA,

calcium salt HC An 81 year old male applied the product to his lawn. He did not shower after use. Approximately 24 post exposure he developed a rash on his entire body. He self treated with anti

- itch cream. He saw his MD, they prescribed itch cream and Benadryl . Approxim ately 3 weeks post
exposure; the rash has cleared on his arms and legs, but is persisting on his chest and back.

018818

- 00054 7/24/2007 INDIANAPOLIS, IN 000239

-

02510 WEED

- B

- GON

CRABGRASS KILLER CONCENTRATE MSMA,

calcium salt HC An adult used the product and got some in their eye. The experienced a visual problem. No further information available.

018915

- 00038 8/21/2007 SAN JOSE, CA 000239

- 02510 WEED

- B

- GON

CRABGRASS KILLER CONCENTRATE MSMA,

calcium salt HC A 68 year old male applied the product to his lawn. He believes the product misted back onto him during use. He used the product for 20 minutes and continued to work outside for 2 hours. Within 1.5

- 2 hours after product application, he developed slurred speech, loss of balance and pain in his neck and back. The next morning his symptoms had resolved. 019025

- 00014 9/8/2007 NJ 000239

- 02510 WEED

- B

- GON

CRABGRASS MSMA,

calcium salt HC An unknown age adult male applied the diluted product to his lawn. Two days

### Page 7 of 8

Incident Package Report Incident

Date Location Reg Number Product Name Ingredient Name Exposure

Severity * Incident Description KILLER CONCENTRATE later, he developed a rash on his arms, fingers, and back. The rash resolved after about 1 week. He used hydrocortisone

cream.

019910

- 00486 6/24/2008 VA 000239

- 02510 WEED

- B

- GON

CRABGRASS KILLER CONCENTRATE MSMA,

calcium salt HC An unknown age adult male applied the product. After application his legs became itchy. The next day he developed a rash. He saw his MD who prescribed oral steroids. He did not take the steroids and his rash healed after about 1 week.

020705

- 00039 3/8/2009 MANTECA, CA 000239

- 02510 WEED

- B

- GON

CRABGRASS KILLER CONCENTRATE MSMA,

calcium salt HC A 71 year old male used the product and did not wash his hands before he ate his lunch. He experienced severe vertigo, double vision and weakness.

021916

- 00043 4/28/2010 NC 000239

- 02510 WEED

- B

- GON

CRABGRASS KILLER CONCENTRATE MSMA,

calcium salt HC An unknown age adult male used the product. About 6 hours later he developed hives from his chest to his legs and he experienced a tingly tongue and tightness in his throat. His han ds also appeared to be swelling. He had no previous allergies.

022251

- 00001 8/11/2010 AL 019713

- 00040

- 073342 IMAGE

HERBICIDE CRABGRASS CONCENTRATE 24 FL OZ MSMA

(and salts) HC An unknown age adult male used this product for 3 years. He has elevated arsenic levels in his blood.

024179

- 00066 5/31/2012 PA 000239

- 02510 WEED

- B

- GON

CRABGRASS KILLER CONCENTRATE MSMA,

calcium salt HC An unknown age adult male used the product and got some on his finger which may have gotten in his mouth when he smoked a cigarette. He experienced a swollen tongue. He was take n to the ER and given an injection of antihistamine and steroids. He had no response so he was given something stronger. He r ecovered one hour later.

### Page 8 of 8

* HC

- Human Moderate ( if the person alleged or exhibited symptoms more pronounced, more prolonged or of a more systemic nature than minor symptoms; and involved some form of treatment, even though symptoms were not life threatening and the person returned to his/her pre

- exposure state of health with no additional residual disability)



### Table 3 : SENSOR

- Pesticide High Severity Incident s involving Metheanearsonic acid, salts SENSOR

- Pesticides Incidents Chemical: Metheanearsonic acid, salts PC Codes: 035301, 035302, 035303, 128920

Incident Year Location Registration Number Product Name Exposure Severity* Incident Description

2007 Texas Not provided Not provided High Case was spraying a customer’s yard, spray rig had a leak and product got on her hands & face. She r eported dermal, ocular and gastrointestinal symptoms.

2003 Texas 01082700039 MSMA High Ex told case he applied Chlordane and MSMA 8/31/03. Case got very sick, remains sick. She also experienced Chloracne. Ex was a licensed applicator. Doctors suspect poisoning by inge stion. The case continues to experience C hl oracne and bout s of fatigue ( 11/05). The case reported f

acial outbreaks from outset. She also

r eported dermal and gastrointestinal symptoms.

2006 Texas 06271900182 MSMA High Sprayed lawn with MSMA & Grazon P+D after work. Following the application the case felt bad

. The n ext night he felt worse and went to the ER. He r eported dermal, nervous system, respiratory and gastrointestinal symptoms. Previous diagnosed with post concussion syndrome suffered from fall 1 year earlier.

* SENSOR

- Pesticides Severity Index 1 Fatal Death resulting from exposures to one or more pesticides 2 High Severe or life

- threatening; involves treatment; commonly hospitalization to prevent death and/or loss

of time >5 days for regular work or normal activities. Signs/symptoms may include coma, c ardiac arrest, renal failure and respiratory depression. 3 Moderate Less severe illness/injury often involving systemic manifestations. Treatment is generally provided.

Individual is able to return to normal functioning without any residual disability. ≥3

- 5 days lost work/normal activity 4 Low Skin, eye, upper respiratory irritation. May also include fever, headache, fatigue or dizziness.

Typically the illness/injury resolves without treatment. Minimal lost time (>3 days) from work/normal activities