<PAGE>

                                                                  EXHIBIT 10.78



                       [CONFIDENTIAL TREATMENT REQUESTED]

[Certain information has been omitted herein pursuant to a request for
confidential treatment pursuant to Rule 24b-2.]


              INVESTMENT, RESEARCH SUPPORT AND MARKETING AGREEMENT


This Agreement is made as of September 29, 1995, by and between Chiron
Corporation, a Delaware corporation ("Chiron") and Ciba-Geigy Limited, a Swiss
corporation ("Ciba"), and Chiron Funding Corporation, a Delaware Corporation
("Newco").

RECITALS:

A.   Ciba previously has agreed to provide funding and support for research and
development activity conducted at Chiron pursuant to the terms of that certain
Investment Agreement dated as of November 20, 1994, among Ciba, Chiron, Ciba-
Geigy Corporation and Ciba Biotech Partnership, Inc. (the "Investment
Agreement").

B.   Ciba and Chiron now wish to implement such support through a newly
organized corporation ("Newco") wholly-owned by Chiron, to which Chiron shall
contribute royalty interests and promotional rights relating to specified
products now under development by Chiron, all as provided below herein.


C.   Chiron from time to time will sell and Ciba agrees to buy from Chiron
shares of common stock of Newco as and when requested by Chiron, subject to the
limitations contained herein, and Chiron will use the proceeds of such sales to
fund the research and development of such products.

D.   Chiron will have an option to repurchase such shares, which option, if
exercised, will commit Chiron to offer to Ciba certain marketing rights with
respect to such products.

AGREEMENTS:

     1.   NEWCO.

     1.01 INCORPORATION.  Chiron has caused Newco to be organized as a Delaware
corporation.

     (a)  ARTICLES OF INCORPORATION.  The Articles of Incorporation are attached
     hereto as Schedule 1.01.


     (b)  BYLAWS.  The Bylaws of Newco shall be adopted by the Board of
     Directors once fully constituted, and will be in standard form, with limits
     on

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     Board of Director action as to specific matters without supermajority
     approval, consistent with the provisions of Section 1.01(e) below.

     (c)  DIRECTORS.  The Board of Directors shall consist of three members, two
     of which shall be appointed by the majority shareholder, with the remaining
     Director appointed by the minority shareholder.  Unless otherwise agreed by
     the parties, one Director appointed by each shareholder will have
     appropriate scientific background.


     The initial Directors will be William Green and Dennis Winger; provided
     that as soon as practicable following the execution of this Agreement,
     Chiron and Ciba shall elect directors in accordance with the preceding
     paragraph.

     (d)  OFFICERS.  Unless otherwise agreed, Newco shall have three officers,
     with the President and one other officer appointed by the Directors
     designated by the majority shareholder, and the remaining office appointed
     by the Directors designated by the minority shareholder.

     The initial officers of Newco shall be Dennis Winger, President, and
     William Green, Secretary; provided that as soon as practicable following
     execution of this Agreement, the Directors designated by Ciba shall appoint
     a third officer  of Newco.


     (e)  ADDITIONAL AGREEMENTS.  Chiron and Ciba further agree as follows:

          (i)  Neither Chiron nor Ciba shall transfer any shares of Newco stock,
          and Newco shall not issue any shares, to any third party without the
          prior written consent of both Chiron and Ciba.

          (ii) Newco shall not enter into any agreements or conduct any
          transactions, other than those specifically authorized in this
          Agreement or the Royalty Agreement, without the approval of both
          Chiron and Ciba.

          (iii)     Ciba shall have the right to require that Newco exercise its
          rights under this Agreement, including without limitation the co-
          promotion option, and under the Royalty Agreement. Each of Chiron and
          Ciba shall be authorized to enforce against the other any and all
          rights of Newco against such other party.

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          (iv) In the event that Ciba acquires a majority interest in Newco, the
          parties agree to hold a shareholders meeting within thirty (30) days
          following the date on which such majority interest is acquired.  At
          such meeting, new Directors shall be elected pursuant to Section
          1.01(c), and new officers shall be appointed pursuant to Section
          1.01(d).

          (v)  At any time, Ciba or Chiron may notify the other party of changes
          in the Directors or officers designated by the notifying party
          hereunder.  Both parties agree promptly to take and to cause Newco to
          take such actions as may be required to implement such changes in
          Directors or officers.

     1.02 CAPITAL.  The authorized capital stock of Newco consists of 300,000
shares of Common Stock (par value $0.01 per share) (the "Newco Stock").

     1.03 INITIAL SHARE ISSUANCE; CONTRIBUTION.  240,000 shares of Newco Stock
have been or promptly shall be issued to Chiron and are or shall be validly
issued, fully paid and non-assessable.  In consideration thereof, Chiron has or
promptly shall effectively contribute to Newco as a capital contribution the
following.:

          (a)  CASH.  Cash in an amount equal to the par value of the Newco
     Stock ($2400.00).

          (b)  ROYALTY.  A royalty agreement in the form of Schedule 1.03B (the
     "Royalty Agreement") with respect to royalties on Adult Vaccines, as
     defined therein.

          (c)  CO-PROMOTION OPTION.  The option to co-promote all Adult Vaccines
     in all countries of the world other than North America and Europe in which
     Newco, directly or indirectly, through Ciba or otherwise, reasonably has
     the field sales force and other promotional infrastructure necessary to
     successfully promote the Adult Vaccines.  In determining such adequacy, the
     capabilities of Ciba's sales force and promotional infrastructure shall be
     deemed to be the field sales force and promotional infrastructure of Newco,
     in all countries where Ciba elects to undertake co-promotion activities.
     Such option shall be exercisable by Newco, on a country by country basis,
     by written notice to Chiron, at any time until 180 days following the
     granting of the first regulatory approval in North America or Europe to
     market and sell the first Adult Vaccine for which such regulatory approval
     is obtained. This option shall terminate automatically as to all Adult
     Vaccines, in any country, with respect to which the option is not exercised
     by Newco within the time limit set forth above, it being understood that it
     may be


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     in the interests of the parties to explore, without obligation, a
     broadening and/or extension of such co-promotion.

               (i)  Upon exercise of the option by Newco, the parties shall
          negotiate in good faith a co-promotion agreement for the
          Adult Vaccines in the countries as to which Newco has exercised its
          co-promotion option, on commercially reasonable terms, which shall
          include (A) a pre-tax  co-promotion profit to Newco of not less than
          [CONFIDENTIAL TREATMENT REQUESTED] of Net Sales of Adult Vaccines in
          such countries, (B) an obligation of reasonable diligence, (C) a
          reservation in favor of Chiron of the right to market to international
          public organizations such as UNICEF and W.H.O, with an appropriate
          compensation to be paid to Newco for any co-promotional activity
          agreed to be provided by Newco supporting such international sales,
          and (D) such other terms as the parties may then agree.  The
          co-promotion right shall expire as to each Adult Vaccine six (6) years
          after the first commercial sale, on a country by country and product
          by product basis.

               (ii)  Newco agrees to exercise such option only in the event that
          Newco is able to contract with Ciba (or other entity acceptable to
          Ciba and Chiron) to perform the co-promotion activities.

               (iii)  Newco, and in the event that Newco has granted  co-
          promotion rights hereunder to Ciba, Newco and Ciba shall keep accurate
          books and records as to its co-promotion, which books and records
          shall be subject to audit by Chiron, in the same manner as set forth
          in Section 3.05.

     1.04 FUTURE SHARE ISSUANCE; CONTRIBUTION.   At any time, upon request of
Chiron, and subject to the approval of Ciba pursuant to Section 2.04, Newco
agrees to issue additional shares to Chiron, up to a maximum  of the total
authorized capital of Newco.  In return for such shares, Chiron agrees to
contribute the following:

          (a)  CASH.   Cash in an amount equal to the par value of the shares
     issued.

          (b)  PRODUCT RIGHTS.   Chiron shall grant to Newco the right to
     participate in marketing opportunities with respect to additional products
     other than Adult Vaccines, based on one or more of the following
     structures, to be determined at Chiron's election, but subject to approval
     by Ciba:

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          (i) ROYALTY INTEREST.  Chiron may grant to Newco the right to receive
     a royalty on net sales of such products, subject to acceptable terms and
     conditions, such as those set forth in the Royalty Agreement.

          (ii)  MARKETING OR PROMOTION RIGHTS.  Chiron may grant to Newco the
     right to participate in the marketing and/or selling in selected markets of
     the identified product(s).  In such event, the parties would agree upon a
     supply arrangement under which Chiron would manufacture the products for
     sale through Newco or upon co-promotion arrangements under which Newco
     would market products sold through Chiron.  Such rights would be subject to
     acceptable terms and conditions, such as stated in Section 1.03 (c) above.

          (iii)  PROFITS INTEREST.  Chiron may grant to Newco the right to
     receive a stated percentage of pre-tax profits and losses from the sale of
     products developed, manufactured and marketed by Chiron arising from the
     contributed project or products subject to acceptable terms and conditions.


2.   SUBSCRIPTION.

     2.01 CIBA OBLIGATION.    From time to time at Chiron's request, subject to
the limitations set forth in this Article 2, during the period commencing with
the date hereof (the "Effective Date") and ending on December 31, 1999 (such
period referred to herein as the "Funding Period"), Ciba agrees to purchase from
Chiron and Chiron Agrees to sell to Ciba shares of Newco Stock at a price of One
Thousand Dollars ($1000.00) per share.

     2.02.     AGGREGATE PURCHASE LIMITATIONS.  Ciba's obligation to purchase
Newco Stock hereunder shall be subject to the following limitations:

          (a)  The Net Purchased Amount, as defined below, shall not exceed  Two
     Hundred Fifty Million Dollars (U.S. $250,000,000); provided, however, that
     such amount may be increased, at Chiron's request, to a maximum of Three
     Hundred Million Dollars (U.S. $300,000,000) pursuant to the Section 5.12 of
     the Investment Agreement.  "Net Purchased Amount" shall mean, at any time,
     the aggregate amount paid to Chiron by Ciba for the purchase of Newco Stock
     pursuant to this Agreement, plus Ciba's share (in proportion to Ciba's
     percentage ownership interest in Newco) of royalties reinvested by Newco
     pursuant to Section 5.01.  The Net Purchased Amount will be reduced by the
     aggregate amount of any dividends or other capital distributions actually
     paid by Newco to Ciba and any profits to Ciba from co-promotion or
     marketing activity

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     by Ciba pursuant to Section 1.03(c), in each case, through the date of any
     required purchase of Newco Stock.

          (b)  The Net Purchased Amount shall not exceed at any time one hundred
     percent (100%) of the R&D Costs, as defined below, of research and
     development projects at Chiron as to which royalty or other interests have
     been granted to Newco pursuant to this Agreement including, initially the
     Adult Vaccines and, subsequently, new projects as contemplated by Sections
     1.04 and 2.04(the "Funded Projects").  As used herein, the "R&D Costs" of
     any Funded Project for a given period shall mean the fully burdened, fairly
     allocated costs of Chiron, on a consolidated basis, as determined under
     Chiron's normal project accounting practices, including reasonable and
     customary allocations of indirect and overhead expenses and charges in the
     nature of depreciation and amortization of capitalized cost, general and
     administrative expenses, and out-of-pocket expenses, to the extent that any
     of the foregoing were or are incurred after January 1, 1995, in connection
     with activities performed pursuant to a Funded Project during the period in
     question.

     2.03 TIMING LIMITATIONS. In no event shall Ciba be obligated to purchase
Newco Stock such that the purchase price paid exceeds

          a)   Fifty Million Dollars (U.S. $50,000,000) in 1995;

          b)   In 1996, One Hundred Million Dollars (U.S. $100,000,000), plus
          any unused portion of the funding limit for 1995 pursuant to section
          2.03(a); and

          c)   For subsequent calendar years, equal annual portions of the
          remaining unexpended aggregate amount under Section 2.02 above.

     2.04 FUNDED PROJECTS.   Chiron agrees to use the proceeds of sales of Newco
Stock to Ciba hereunder solely for the purpose of research and development
activities with respect to Funded Projects, determined in accordance with this
Section 2.04.

          (a)  In conjunction with any request by Chiron for the issuance of
     additional Newco Stock pursuant to Section 1.04, Chiron shall provide to
     Ciba proposals for research and development programs which Chiron desires
     to fund or partially fund as Funded Projects through the sale of such
     additional Newco Stock to Ciba.  No limitation shall be placed upon the
     number of Funded Projects that Chiron may present to Ciba during the
     Funding Period.

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          (b)   Upon acceptance by Ciba of a proposal pursuant to Section
     2.04(a), Newco shall be authorized to issue additional Newco Stock pursuant
     to Section 1.04, and the proposed project shall become a Funded Project.  A
     Funded Project shall remain a Funded Project for purposes of this Agreement
     unless or until  Chiron elects, in its sole discretion, to discontinue
     research and development with respect to such project.  Chiron will manage
     the research with respect to Funded Projects in its sole discretion.

          (c)  Chiron will prepare, in consultation with Ciba,  annual and
     quarterly forecasts of the R&D Costs for each Funded Project.

     2.05 SALES OF NEWCO STOCK.  From time to time, not more frequently than
once per fiscal quarter and prior to the conclusion of the fiscal quarter,
Chiron shall provide Ciba with a written notice of the amount of Newco Stock
that it wishes to sell to Ciba, and the associated purchase price, all in
accordance with the provisions of this Article 2.  Such purchase price shall not
exceed the lesser of  (i) 100% of R&D Costs of the Funded Projects incurred on
or after January 1, 1995 and not previously funded through sales of Newco Stock
hereunder; or (ii) the maximum funding obligation of Ciba pursuant to Section
2.03 for the period  in question.  Ciba shall purchase the requested amount of
Newco Stock, by paying the purchase price in U.S. dollars in immediately
available funds, by wire transfer, unless otherwise mutually agreed.  The
purchase price of the initial Newco Stock to be sold  pursuant to Section 2.06
shall be due and payable upon execution of this Agreement.  As to all subsequent
sales of Newco Stock, the purchase price shall be due and payable within thirty
(30) days following the notice delivered by Chiron to Ciba pursuant to this
Section 2.05.

     2.06 INITIAL PURCHASE.  As of the date hereof, Chiron agrees to sell and
Ciba agrees to purchase Twelve Thousand (12,000) shares of Newco Stock and in
consideration thereof Ciba shall promptly pay to Chiron by wire transfer Twelve
Million Dollars (U.S.$12,000,000).

     3.   CHIRON RESEARCH AND DEVELOPMENT ACTIVITY.

     3.01 DILIGENCE.  Chiron shall use reasonable commercial diligence to pursue
and complete the research and to develop, test, gain regulatory approval for,
market and sell the products of the Funded Projects. In the event that less than
100% of the R & D Costs of a Funded Project is provided to Chiron hereunder,
Chiron nevertheless shall spend its own portion of such R & D Costs in
conducting activities related to the Funded Project

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     3.02.     ALLOCATION OF FUNDING.  Where a Funded Project includes more than
one product under development, and in the event that more than one Funded
Project is subject to funding pursuant to Section 2.04, funds received by Chiron
through sales of Newco Stock or from Newco as reinvested net income shall be
allocated, on a quarterly basis,  as follows.  First, such funds shall be
allocated to Funded Projects, in accordance with the R&D Costs of each Funded
Project actually incurred during the most recently completed fiscal quarter, as
a percentage of the total R&D Costs of all Funded Projects incurred during such
period.  Second,  the funds allocated to each Funded Project will be further
allocated to each product within such Funded Project, in accordance with  the
R&D Costs  of such product actually incurred during such period, as a percentage
of the R&D Costs of the entire Funded Project incurred during such period. In
the event that funds received by Chiron exceed the R&D Costs incurred in such
most recently completed quarter, the excess shall be allocated, prorata, to R&D
Costs incurred after the Effective Date and not previously funded or reimbursed
hereunder, whether through the sale of Newco Stock to Ciba or the reinvestment
of Newco net income.

     3.03 NO WARRANTY OF SUCCESS.  CHIRON MAKES NO WARRANTIES OR GUARANTEES OF
ANY KIND THAT THE RESEARCH AND DEVELOPMENT ACTIVITIES FUNDED  HEREUNDER WILL BE
SUCCESSFUL OR WILL ACTUALLY RESULT IN ANY MARKETED PRODUCTS.

     3.04 RIGHTS TO INVENTIONS.  Nothing in this Agreement will cause Ciba or
Newco to obtain any ownership or license rights in any patent or other
intellectual property rights of Chiron in connection with any Funded Project; or
any other right or license not specifically granted herein or in the Royalty
Agreement.  Chiron will own the right, title and interest in and to any new
inventions arising in the course of any Funded Project, to the extent such
inventions are made by Chiron, its employees, agents or assignors.

     3.05 AUDIT RIGHTS.  Chiron agrees to keep accurate books and records of the
funding received through sales of Newco Stock hereunder, the R & D Costs
incurred with respect to Funded Projects, and the allocation of such funding
pursuant to Section 3.02.  Ciba shall have the right, at its own expense, for a
period of three (3) years after the end of the Funding Period,   to have an
independent certified public accountant ("CPA") reasonably acceptable to Chiron
examine the relevant books and records Chiron, during normal business hours, at
the principal offices of Chiron, upon two (2) weeks advance written request, to
verify the R & D Costs or the allocation thereof to Funded Projects; provided,
however, that such audits shall not occur more than once per year.  Said CPA
shall be under confidentiality obligations to Chiron, to reveal  only

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whether there is an error in the R & D Costs or allocation reported to Ciba, and
if so, the amount of such error.

     4.   REPURCHASE RIGHT.

     4.01 RIGHT TO REPURCHASE NEWCO STOCK.  Chiron shall have the right (the
Buy-Out Right") to repurchase from Ciba all Newco Stock sold to Ciba under this
Agreement upon tender by Chiron to Ciba of payment in the amount of the Buyout
Amount (as hereinafter defined) in effect at the time of such tender; provided
that such right shall expire if such tender is not made prior to January 1,
2002.

     As used herein, "Buyout Amount" shall mean an amount equal to (i) the sum
of all stock purchase payments made by Ciba prior to the date of such tender
pursuant to this Agreement, PLUS (ii) interest thereon from the date of payment
until the date of such tender at a rate equal to LIBOR determined and compounded
on a quarterly basis,  LESS (iii)  the aggregate amount of any dividends or
other capital distributions received or receivable by Ciba from Newco and any
pre-tax profits received by Ciba from co-promotion or marketing activity by Ciba
pursuant to Section 1.03(c), to the date of such tender, which exceed the pre-
tax profits which would ordinarily be payable to a third party conducting such
co-promotion or marketing activity, LESS (iv) interest on the amounts referenced
in (iii) above from the date of actual receipt of such amount by Ciba until the
date of such tender at a rate equal to LIBOR determined and compounded on a
quarterly basis.  Amounts reinvested in research and development at Chiron
pursuant to Section 5.01 shall not be deemed payments to Ciba subject to (iii)
above; but payments made to Ciba pursuant to Section 5.02 shall be subject to
(iii) above.

     4.02 FORM OF PAYMENT.    Chiron shall be entitled to make the payment of
the Buyout Amount in the form of cash, in immediately available funds, or Chiron
Common Stock ("Chiron Stock"), or a combination of the two.  If Chiron shall
elect to employ Chiron Stock for the purposes of making such payment, such
Chiron Stock shall be valued at its Fair Market Value as of the date immediately
preceding the date on which such payment shall be made.  As used herein, "Fair
Market Value" shall mean, as of any date of determination, the average of the
closing sale prices of Chiron Stock during the 10 trading day period immediately
preceding such date of determination on the principal United States securities
exchange registered under the Exchange Act on which Chiron Stock is listed, or,
if Chiron Stock is not listed on any such exchange, the average of the closing
sale prices or the closing bid quotations of the Chiron Stock during the 10
trading day period preceding such date of determination on the NASDAQ National
Market or any comparable system then in use, or, if no such quotations are
available, the fair market value of the Chiron Stock as of such date of
determination as determined in good  faith by a majority of the Independent
Directors,

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as defined in that certain Governance Agreement among Ciba, Chiron and Ciba-
Geigy Corporation dated as of November 20, 1994.

     4.03 EFFECT ON CO-PROMOTION RIGHT.  If, at the time of repurchase by Chiron
of Newco Stock pursuant to this Article 4, Newco has exercised the option to co-
promote the Adult Vaccines in one or more countries, pursuant to Section
1.03(c), and has contracted with Ciba to perform such obligations, Ciba shall
have the right to continue to co-promote Adult Vaccines then subject to said
right in such countries for the remainder of the term of such co-promotion
rights, all on the terms set forth in  Section 1.03(a), together with the
further rights set forth in Section 4.04..

     4.04 RESIDUAL RIGHTS.   In the event that Chiron exercises its right to
repurchase all of the Newco Stock pursuant to this Article 4, Chiron agrees to
grant to Ciba the option (the Residual Rights Option) to expand its marketing
rights, if any, with respect to all Adult Vaccines, as provided in this Section
4.04 (the "Residual Rights").  If exercised, Ciba would have the right to
convert its co-promotion right into the right to exclusively market and sell all
Adult Vaccines, in all countries of the world other than North America and
Europe, in which Ciba then has the right to co-promote any Adult Vaccine
pursuant to Section 1.03(c) and to extend such exclusive marketing for a period
of six (6) years from the later of the date of Ciba's exercise of the Residual
Rights Option or the first approval for commercial sale, on a product by product
basis.

          (a)  The Residual Rights Option shall be exercisable by Ciba, by
     written notice to Chiron,  during the 60 days following Chiron's exercise
     of its Buy-out Right.  Upon exercise of the Residual Rights Option by Ciba,
     the parties shall negotiate in good faith an agreement under which Chiron
     would manufacture and supply, and Ciba would market, sell and distribute,
     the Adult Vaccines in the countries as to which Ciba has Residual Rights,
     all on commercially reasonable terms, including reasonable and customary
     distributor obligations to use diligence and to pursue and pay the cost of
     regulatory approvals and other marketing, selling and product introduction
     activities.

          (b)  Such agreement shall provide for a pre-tax distributor profit to
     Ciba of not less than [CONFIDENTIAL TREATMENT REQUESTED] of Net Sales by
     Ciba of Adult Vaccines in such countries.  In the event that the Net
     Purchase Price, as defined in Section 2.02 is less than $250,000,000, such
     minimum pre-tax distribution profit payable to Ciba hereunder will be
     reduced by multiplying [CONFIDENTIAL TREATMENT REQUESTED] of net sales by
     the following fraction:

                               NET PURCHASE PRICE
                            ------------------------
                                  $250,000,000


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          (c)  Ciba's exclusive rights pursuant to this Section 4.04 shall be
     subject to the continuation of such promotional and sales activity as
     Chiron may be  permitted to conduct under any applicable co-promotion and
     other marketing agreements entered into between Chiron and Newco or Ciba
     prior to the exercise of Chiron's Buy-Out Right and to the negotiation of
     equitable and reasonable terms for (i) the phase out such activity by
     Chiron after the expiration of the original terms of such agreements and
     (ii) compensating Ciba for the reduction of such exclusivity by reason of
     Chiron's continued activity.

     4.05 COOPERATION.  Chiron and Ciba shall meet and confer from time to time
to consider whether and to what extent it is in their respective best interests
to permit Chiron to participate in marketing of Adult Vaccines on a county-by-
country basis.  Nothing in this Section 4.05, however, shall obligate Newco or
Ciba either (i) to exercise the options to acquire co-promotion rights or
Residual Rights or (ii) if Ciba exercises the option to acquire the Residual
Rights, to permit Chiron to participate in such Residual Rights, other than as
provided in Section 4.04(c), except to the extent that Ciba determines it to be
in its best interest to do so in the reasonable exercise of its discretion.

     5.   REINVESTMENT OF INCOME BY NEWCO.

     5.01 OBLIGATION TO REINVEST INCOME.  During the Funding Period, Newco
agrees that it will invest all revenues it receives pursuant to the Royalty
Agreement or the co-promotion option or otherwise less payments to Ciba or
others for co-promotion services and any expenses of otherwise doing business,
as follows.  Newco shall enter into a research and development funding agreement
with Chiron pursuant to which it will provide funding to Chiron for the R & D
Costs of the Funded Projects.  In return for such funding, Newco shall receive
the right to increased royalties on products arising from the Funded Projects in
question, as provided in Section 1.01(b) of the Royalty Agreement.  Chiron shall
use such funding to pay for the R&D Costs of the Funded Projects in the final
period in which they are received to the maximum extent possible and to pre-pay
the R&D Cost of the Funded Project forecast to be incurred over the remainder of
the Funding Period.  To the extent so paid or prepaid, the R&D Costs shall not
be eligible for funding hereunder, and therefore, shall not be used to calculate
the limitation on the  Net Purchased Amount under Section 2.02(b).

     5.02 TERMINATION OF SUCH OBLIGATION.  In the event that during the Funding
Period there are no unfunded R & D Costs of the Funded Projects; or in the event
that income is received by Newco following the end of the Funding Period, Chiron
and Ciba shall meet and confer as to the use of any income.  If the parties
cannot agree on another resolution, following the end of the Funding Period, all
cash held or received by Newco in excess of its needs shall be distributed to
the stockholders of Newco  by dividend,  subject to applicable law.

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     6.   ACTION BY CIBA MEMBERS OF CHIRON BOARD.

     Ciba agrees that the members of the Chiron Board of Directors which are
designated by Ciba pursuant to that certain Governance Agreement dated as of
November 20, 1994, shall refrain from voting, or otherwise acting to direct or
control Chiron, with respect to any matter relating to the Funded Projects or
Chiron's ownership of Newco Stock, or Chiron's exercise of its rights to
repurchase Newco Stock hereunder.

     7.   CONFIDENTIALITY.

     During the term of this Agreement and for a period of five (5) years
following the expiration or termination of this Agreement, Newco and Ciba agree
to maintain in confidence all confidential or proprietary information of Chiron
("Confidential Information") which is disclosed to Newco or Ciba pursuant to
this Agreement.  Newco and Ciba shall use such Confidential Information only as
permitted by this Agreement and shall not disclose the same to anyone other than
its employees, agents or consultants, as are necessary for the purposes of this
Agreement.  Any such disclosure shall be on terms and conditions at least as
restrictive as those contained herein.


     The foregoing obligation of confidentiality shall not apply to the extent
that (a) Newco and Ciba are required to disclose information by law, order or
regulation of a governmental agency or a court of competent jurisdiction, and
provides Chiron with reasonable notice prior to such disclosure, and cooperates
with Chiron in seeking such protection for such disclosed information as Chiron
may determine; or  (b) Newco or Ciba can demonstrate that:  (i)  the information
was at the time of receipt already in the public domain or thereafter entered
the public domain other than as a result of actions of Newco, Ciba, or any of
their respective employees, consultants, or agents, in violation hereof; (ii)
the information was rightfully known by Newco and Ciba prior to the date of
receipt hereunder; or (iii) the  information was disclosed to Newco or Ciba by a
third party  source not under a duty of confidentiality to Chiron; or (iv) the
information was independently developed by Newco or Ciba by employees, agents or
consultants who had no access to the Confidential Information.

     8.   INDEMNIFICATION

     Chiron agrees to indemnify, defend and hold Newco and Ciba harmless from
and against any and all claims, losses, damages, liabilities, costs and expenses
(including reasonable attorneys' fees) (collectively, "Claims") arising as a
result of

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Chiron's research and development activities which are funded pursuant to this
Agreement, or as a result of the manufacture, use or sale of any product arising
from a Funded Project, except to the extent that such Claims result from (i)
marketing, sale or promotion of the product by Newco, Ciba, or their respective
affiliates or licensees, in deviation from the approved labeling for the product
in question, or (ii) negligence or willful misconduct of Newco, Ciba, or their
respective employees, agents or consultants.

     Newco and Ciba agree to notify Chiron promptly after receipt of notice of
any Claim, and to cooperate with Chiron in connection with the investigation and
defense of any Claim.  Chiron shall have the  right to control such defense,
using counsel selected by Chiron, provided that Newco and Ciba shall each have
the right to participate in such defense through its own counsel, at its sole
expense.  Chiron shall have the sole right to control the settlement or
disposition of any such Claim, provided that Chiron shall not settle or
compromise any Claim in any manner which would materially adversely impact the
rights or activities of Newco or Ciba without prior written consent of Newco or
Ciba, as the case may be, which consent shall not be unreasonably withheld.

     9.   MISCELLANEOUS.

     9.01 OBLIGATIONS UNDER OTHER AGREEMENTS.  The promotional and marketing
options hereunder are in lieu of the application of Sections 3.02 and 4.02 of
that certain Cooperation and Collaboration Agreement between Chiron and Ciba
dated as of November 20, 1994, with respect to all products arising from the
Funded Projects.  All obligations in such Sections are suspended during the term
of this Agreement, the Royalty Agreement and any co-promotion or marketing
agreements hereunder with respect to the products covered hereby and thereby.

     9.02 ASSIGNMENT.   Neither party shall have the right to assign any of its
rights or obligations hereunder to any unaffiliated third party without the
prior written consent of the other party hereto, which consent shall not be
unreasonably withheld.  Subject to the foregoing, this Agreement shall be
binding on, and inure to the benefit of, the parties, their successors and
permitted assigns.

          9.03 SEVERABILITY.    If any provision of this Agreement should be
held invalid or unenforceable, the remaining provisions hereof shall be
unaffected and shall remain in full force and effect without regard to such
invalid or unenforceable provisions, provided that such remainder is consistent
with the intent of the parties as evidenced by this Agreement as a whole.

                                       13
<PAGE>

     9.04 AMENDMENT.    This Agreement may not be modified or amended except in
writing signed by both parties.

     9.05 ENTIRE AGREEMENT.    This Agreement and the Royalty Agreement
represent the entire agreement of the parties with respect to the subject matter
hereof, and supersedes all prior negotiations and agreements, including without
limitation Exhibit B to the Investment Agreement.

     9.06.     GOVERNING LAW.  This Agreement shall be governed by and construed
in accordance with the laws of the State of Delaware.

     9.07 COUNTERPARTS.  This Agreement may be executed in one or more
counterparts, each of which shall be deemed an original, and all of which
together shall constitute a single agreement.

                                       14
<PAGE>

     9.08 INDEPENDENT CONTRACTORS.  The parties hereto are independent
contractors.  Nothing herein shall construed to constitute Chiron and Ciba or
Newco as joint venturers or partners with respect to the subject matter hereof.


Executed by the parties, effective as of the Effective Date.


CHIRON CORPORATION


By        /s/ William G. Green
          --------------------------------

Title     Senior Vice-President and
          General Counsel
          --------------------------------

Date      September 29, 1995
          --------------------------------




CIBA-GEIGY LIMITED


By        /s/ R. A. Meyer                    /s/ Dr. Herbert Gut
          --------------------------------   --------------------------------

Title     Member of the Executive
          Committee/CFO                      Senior Division Counsel
          --------------------------------   --------------------------------

Date
          --------------------------------   --------------------------------



CHIRON FUNDING CORPORATION

By        /s/ Dennis Winger
          --------------------------------

Title     President
          --------------------------------

Date      September 29, 1995
          --------------------------------

                                       15


<PAGE>

                                                                   Schedule 1.01

                          CERTIFICATE OF INCORPORATION
                                       OF
                           CHIRON FUNDING CORPORATION

                                    * * * * *

                                                         [COPY - NOT FOR FILING]

     1.   The name of the corporation is Chiron Funding Corporation.

     2.   The address of its registered office in the State of Delaware is
Corporation Trust Center, 1209 Orange Street, in the City of Wilmington, County
of New Castle.  The name of its registered agent at such address is The
Corporation Trust Company.

     3.   The nature of the business or purposes to be conducted or promoted is
to engage in any lawful act or activity for which corporations may be organized
under the General Corporation Law of Delaware.

     4.   The total number of shares of stock which the corporation shall have
authority to issue is Three Hundred Thousand (300,000) and the par value of each
of such shares is Zero Dollars and One Cent ($0.01) amounting in the aggregate
to Three Thousand Dollars and No Cents ($3,000.00).

     5.   The board of directors is authorized to make, alter or repeal the by-
laws of the corporation.  Election of directors need not be by written ballot.

     6.   The name and mailing address of the sole incorporator is:

                         Corporation Trust Center
                         1209 Orange Street
                         Wilmington, Delaware  19801

     7.   A director of the corporation shall not be personally liable to the
corporation or its stockholders for monetary damages for breach of fiduciary
duty as a director except for liability (i) for any breach of the director's
duty of loyalty to the corporation or its stockholders, (ii) for acts or
omissions not in good faith or which involve intentional misconduct or a knowing
violation of law, (iii) under Section 174 of the Delaware General Corporation
Law, or (iv) for any transaction from which the director derived any improper
personal benefit.

     8.   The corporation shall indemnify its officers, directors, employees and
agents to the extent permitted by the General Corporation Law of Delaware.

     I, THE UNDERSIGNED, being the incorporator hereinbefore named, for the
purpose of forming a corporation pursuant to the General Corporation Law of the
State of Delaware, do make this certificate, hereby declaring and certifying
that this is my act and deed and the facts herein stated are true, and
accordingly have hereunto set my hand this       day of          , 19      .
                                           -----        --------      ------

                            -------------------------
                                Sole Incorporator

                                     Page 1
<PAGE>


                                                                SCHEDULE 1.03B

                                ROYALTY AGREEMENT

                             BIOCINE ADULT VACCINES


     This Royalty Agreement is made effective as of September 29, 1995, by and
between Chiron Corporation ("Chiron"), a Delaware corporation, and Chiron
Funding Corporation, a Delaware Corporation ("Newco").

RECITALS.

     Chiron, Newco and Ciba-Geigy Limited, a Swiss corporation ("Ciba") have
entered into a Subscription Agreement of even date herewith (the "Subscription
Agreement").  The parties wish to set forth the terms under which Chiron will
pay to Newco royalties on certain adult vaccine products of The Biocine Company
identified on Schedule A hereto (the "Adult Vaccines"),  as contemplated in
Section 1.03 of the Subscription Agreement.

AGREEMENTS.

All capitalized terms not defined in this Agreement shall have the meanings set
forth in the Subscription Agreement.

1.   ROYALTIES

     1.01 OBLIGATION TO PAY ROYALTIES.  In consideration of the Newco Stock
issued to Chiron pursuant to Section 1.03 of the Subscription Agreement, subject
to the terms and conditions set forth herein, Chiron hereby agrees to pay to
Newco royalties on the Adult Vaccines identified in Schedule 1.01 hereto as
follows.

          (a)  ROYALTY RATE.  The royalty rate for each Adult Vaccine shall be a
     percentage of worldwide Net Sales, as defined below, which rate shall be
     calculated as of the date on which the Chiron or its Affiliates, as defined
     below, first receive regulatory approval to market and sell such Adult
     Vaccine in the first country in Europe or North America in which such
     approval is obtained.  If such approval is obtained during the Funding
     Period, the royalty rate will be recalculated at the end of the Funding
     Period as provided below.

     Royalty Rate = [CONFIDENTIAL TREATMENT REQUESTED] x The
                    [CONFIDENTIAL TREATMENT REQUESTED] x  The
                    [CONFIDENTIAL TREATMENT REQUESTED]

          Wherein:  The [CONFIDENTIAL TREATMENT REQUESTED] equals [CONFIDENTIAL
     TREATMENT REQUESTED], when [CONFIDENTIAL TREATMENT REQUESTED] is the
     prorata portion of [CONFIDENTIAL TREATMENT REQUESTED], as defined below,
     attributable to such Adult Vaccine pursuant to Section 2.06 of the
     Subscription Agreement and [CONFIDENTIAL TREATMENT REQUESTED] is the

                                        1
<PAGE>

     [CONFIDENTIAL TREATMENT REQUESTED] for such Adult Vaccine.  The
     [CONFIDENTIAL TREATMENT REQUESTED] equals [CONFIDENTIAL TREATMENT
     REQUESTED], but not greater than one (1), when [CONFIDENTIAL TREATMENT
     REQUESTED] is [CONFIDENTIAL TREATMENT REQUESTED] plus the amount of
     [CONFIDENTIAL TREATMENT REQUESTED],  and [CONFIDENTIAL TREATMENT REQUESTED]
     is the [CONFIDENTIAL TREATMENT REQUESTED] for [CONFIDENTIAL TREATMENT
     REQUESTED] of the Adult Vaccines.  [CONFIDENTIAL TREATMENT REQUESTED]
     means, on a [CONFIDENTIAL TREATMENT REQUESTED] basis for the [CONFIDENTIAL
     TREATMENT REQUESTED], and on a [CONFIDENTIAL TREATMENT REQUESTED] basis for
     the [CONFIDENTIAL TREATMENT REQUESTED], the [CONFIDENTIAL TREATMENT
     REQUESTED] of the Adult Vaccine(s) in question incurred during the
     [CONFIDENTIAL TREATMENT REQUESTED].  [CONFIDENTIAL TREATMENT REQUESTED]
     for an Adult Vaccine means the [CONFIDENTIAL TREATMENT REQUESTED] incurred
     by Chiron or its Affiliates with respect to such Adult Vaccine from
     [CONFIDENTIAL TREATMENT REQUESTED].  The [CONFIDENTIAL TREATMENT REQUESTED]
     incurred by Chiron [CONFIDENTIAL TREATMENT REQUESTED] for each Adult
     Vaccine has been provided to and approved by Ciba prior to the date hereof.

          For a royalty calculation made prior to the end of the Funding Period,
     the [CONFIDENTIAL TREATMENT REQUESTED] will be deemed to be one (1).  At
     the end of the Funding Period, the royalty shall be recalculated based on
     the actual [CONFIDENTIAL TREATMENT REQUESTED] determined at that time.

          For example, if the amount of [CONFIDENTIAL TREATMENT REQUESTED]
     hereunder for [CONFIDENTIAL TREATMENT REQUESTED] is [CONFIDENTIAL
     TREATMENT REQUESTED] and the [CONFIDENTIAL TREATMENT REQUESTED] of
     [CONFIDENTIAL TREATMENT REQUESTED] is [CONFIDENTIAL TREATMENT REQUESTED]
     and if the [CONFIDENTIAL TREATMENT REQUESTED] of [CONFIDENTIAL TREATMENT
     REQUESTED] is [CONFIDENTIAL TREATMENT REQUESTED], then the royalty payable
     to Newco will be:

<TABLE>
     <C>                    <C>                    <C>                    <S>
        [CONFIDENTIAL     x    [CONFIDENTIAL     x    [CONFIDENTIAL     =    [CONFIDENTIAL
     TREATMENT REQUESTED]   TREATMENT REQUESTED]   TREATMENT REQUESTED]   TREATMENT REQUESTED]
                            --------------------   --------------------
                               [CONFIDENTIAL          [CONFIDENTIAL
                            TREATMENT REQUESTED]   TREATMENT REQUESTED]

        [CONFIDENTIAL     x    [CONFIDENTIAL     x    [CONFIDENTIAL     =    [CONFIDENTIAL
     TREATMENT REQUESTED]   TREATMENT REQUESTED]   TREATMENT REQUESTED]   TREATMENT REQUESTED]
</TABLE>

          (b)   REINVESTMENT OF ROYALTIES.  Pursuant to Section 4 of the
     Subscription Agreement, Newco has agreed that it will reinvest its net
     income, including royalties actually received  pursuant to this Section
     1.01 during the Funding Period, to pay or prepay R & D Costs of the Funded
     Projects at Chiron. The amount of all such funding which is reinvested by
     Newco will be included as part of the Aggregate Fraction, as provided in
     Section 1.01(a) with respect to the Adult Vaccines to which such funding is
     allocated.

          (c)  ADJUSTMENT FOR LACK OF PATENT PROTECTION.  Royalties payable
     hereunder shall be reduced by [CONFIDENTIAL TREATMENT REQUESTED] with
     respect to Net Sales in any country in which the sale of the Adult Vaccine
     in question is not covered by any patents or patent applications held by
     Chiron or its Affiliates, whether due to the lack of patent applications,
     adjudicated invalidity of patents, or expiration of patents prior to the
     end of the royalty term.

                                        2
<PAGE>

          (d)  "AFFILIATES."  As used herein, Affiliates of Chiron shall include
     all entities controlled by Chiron, but shall not include Newco and shall
     not include Ciba or any entity controlled by or under common control with
     Ciba which is not also controlled by Chiron.  Affiliates of Chiron
     specifically include The Biocine Company and Biocine S.p.A.

2.   NET SALES.  As used herein, "Net Sales" means the invoiced price of a
     product sold by Chiron, its affiliates or licenses, less (i) discounts,
     rebates, chargebacks and allowances; (ii) credits or refunds for returned
     or damaged goods; (iii) sales, use, excise, value added and similar taxes;
     (iv) customs, export and import duties and other governmental charges; (v)
     transportation and insurance charges; (vi) royalties payable to third
     parties; (vii) costs incurred by Chiron, including amounts payable in
     damages or settlement, in defending claims by third parties that the
     products infringe third party intellectual property rights.

     In the event that a product is sold in combination with another active
     ingredient, or with a delivery system not developed as part of the Funded
     Project, or with instrumentation, or with other components in a kit, or
     with services related to the use of the product (all collectively referred
     to as "Other Components", and the resulting product referred to as a
     "Combination Product"), the parties shall reasonably determine the portion
     of Net Sales of the Combination Product which should be allocated to the
     product arising from the Funded Project.  If the product arising from the
     Funded Project and the Other Components are sold separately, the Net Sales
     for the purpose of this Agreement shall be determined by multiplying the
     gross invoiced price of the Combination Product, less the deductions
     specified above, by a the fraction A/(A+B), where A is the selling price of
     the products arising from the Funded Project, and B is the selling price of
     the Other Components.  If no such separate sales are made, the appropriate
     allocation shall be negotiated in good faith by the parties.

3.   ROYALTY TERM. Royalties payable hereunder shall commence with the first
     commercial sale of the Adult Vaccine in question, and shall continue, on a
     country by country basis, until the later of the expiration of applicable
     patent protection for the Adult Vaccine in such country, or ten (10) years
     following the first commercial sale of such Adult Vaccine in such country.

4.   ROYALTY PAYMENTS AND REPORTS

     4.01.  PAYMENTS.  All royalties payable to Newco hereunder shall be paid in
     U.S. Dollars, on a quarterly  basis within ninety (90) days following the
     close of Chiron's fiscal quarter, with respect to Net Sales of Adult
     Vaccines during such fiscal quarter.

     4.02.  REPORTS.  Each royalty payment shall be accompanied by  a written
     report setting forth in reasonable detail the Net Sales of Adult Vaccines
     by

                                        3
<PAGE>

     Chiron, its affiliates and licensees during the applicable period and the
     resulting calculation of the royalty payment due hereunder.   For the
     purposes of determining royalties hereunder, Net Sales shall be calculated
     in the currency of the country of sale and then converted to U.S. Dollars
     in accordance with Chiron's standard accounting practices.

     4.03.  TAXES.  If law or regulation requires withholding of any taxes on
     payments with respect to Net Sales in any given country to Chiron, its
     affiliates or licensees, or on payments due to Newco hereunder,  such taxes
     will be deducted  on a country-by-country basis from such remittable
     payment, and the amounts due to Newco hereunder shall be remitted net of
     such withheld taxes.  Chiron shall provide Newco with documentation of any
     such withholding or other taxes paid hereunder with respect to tax
     liability of Newco.

     4.04.  BLOCKED CURRENCY.  If, in any country, the transfer of payment to
     Chiron,  its affiliates or sublicensees with respect to Net Sales, or the
     transfer of royalties to Newco hereunder, is prohibited by law or
     regulation, the payment obligations to Newco hereunder with respect to the
     amounts so restricted shall be fully satisfied upon payment of the amounts
     due to Newco in local currency to a bank account in Newco's name in such
     country.  The parties agree to cooperate in their efforts to resolve any
     such blocked currency situation.


5.  AUDIT RIGHTS.  Chiron agrees to keep accurate books and records of the sales
of all Adult Vaccines.  Newco and Ciba shall have the right, at Ciba's expense,
for a period of three (3) years after each report delivered pursuant to Section
4.02 to have an independent certified public accountant ("CPA") reasonably
acceptable to Chiron examine the relevant books and records Chiron and its
affiliates, during normal business hours, at the principal offices of Chiron,
upon two (2) weeks advance written request, to verify the calculation of any
royalty payment; provided, however, that such

                                        4
<PAGE>

audits shall not occur more than once per year.  Said CPA shall be under
confidentiality obligations to Chiron, to reveal  only whether there is an error
in the calculation of a royalty payment owed hereunder, and if so, the amount of
such error.

     Executed by the parties as of the date first written above.

CHIRON CORPORATION


By
          --------------------------------

Title
          --------------------------------



CHIRON FUNDING CORPORATION


By
          --------------------------------

Title
          --------------------------------





                                        5
<PAGE>

                                   SCHEDULE A


                                 ADULT VACCINES

Herpes Simplex Virus Vaccine (prophylactic and therapeutic use)

Hepatitis C Virus Vaccine (prophylactic and therapeutic use)

Cytomegalovirus Vaccine

Adjuvanted Hepatitis B Vaccine

Human Papilloma Virus Vaccine

Human Immunodeficiency Virus Vaccine







                                        6