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                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    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                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             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|   | *This staff working paper was discussed at the Council's February 2002 meeting. It was prepared by staffsolely to aid discussion, and does not represent the official views of the Council or of the United States Government.*Staff Working Paper **On             Terminology**Introduction: The Importance of Careful Use        of NamesThere is a great deal of confusion about the        terms used in discussing human cloning. There is honest disagreement about        what names should be used, and there are also attempts to select and use        terms in order to gain advantage for a particular moral or policy position.        It is terribly important to try to be accurate and fair in the matter        of language. Choice of names can decisively affect the way questions are        posed, and hence how answers are given. Efforts to win the moral argument        by Orwellian use of speech must be resisted. The issue is not a matter        of semantics; it is a matter of trying to call things by their right names,        of trying to fit speech to fact as best one can. We should not only stipulate        the meanings we intend by our use of terms; we should also choose terms        that most accurately convey the descriptive reality of the matter at hand.        If this is well done, the moral argument can then proceed on the merits,        without distortion by linguistic sloppiness or chicanery. Many of the terms that appear in the cloning debate are confusing or are        used in a confused manner. There are difficulties concerning the terms        that seek to name the *activity* or *activities* involved: cloning,        asexual reproduction, reproductive cloning, research cloning, therapeutic        cloning, somatic cell nuclear transfer (or nuclear transplantation), nuclear        transfer for stem cell research, nuclear transfer for regenerative medicine.        There are difficulties concerning the terms that seek to name the *"product"*or *"products"* of the activities: cell, activated cell,        clump of cells, reconstituted (or reconstructed) egg, zygote, embryo,        human embryo, blastocyst, potential human being, human being, clone, person.        And there are difficulties concerning the terms that seek to describe        the *relation* between the "product" and the person whose        somatic cell nucleus was transferred to produce "it": genetic        copy, replica, genetically virtually identical, non-contemporary twin,        clone. Let us try to sort out the terms by beginning with the nature of the *activity*or the *deed* done in the activity of cloning. As a prelude to doing        so, some general observations will be helpful. Although all aspects of        an activity or action are relevant to understanding its full human meaning,        when describing a deed we do well to distinguish WHAT it is from both        HOW it is done and WHY it is done. The act itself (WHAT) may be accomplished        by a variety of means or techniques (HOW), and it may be undertaken for        a variety of motives or purposes (WHY). To be sure, there is disagreement        about the degree to which the motives or purposes of the agent are to        be reckoned in the description of the act itself. For example, do the        different motives make an act of "mercy-killing" different AS        AN ACT from murdering a person or killing a murderer or killing someone        in self-defense? Or are they all equally acts of homicide (killing of        a human being) whose MORAL meaning we can then proceed to debate, if we        wish, by attending not only to the act itself but also to the agent's        motive and purpose? (See Meilaender comment on "Distinguishing Motive        and Intention.") Though we do not wish to beg this question, the        very existence of this disagreement suggests that we do well not to ignore        the naked act itself, since it may well have a meaning independent of        what moved the agent. To illustrate: in vitro fertilization (IVF: the extra-corporeal -- *in        vitro* = in glass -- merging of egg and sperm, creating a zygote that        is the beginning stage of a new living being) is the WHAT. It is an act        of "fertilization," of making fertile, of making the egg cell        ready and able to develop into the human organism. This fertilization        may be accomplished in at least two ways (HOW): by merely mixing egg and        sperm, allowing the sperm to find and penetrate the egg, or by the technique        of injecting individual sperm directly into the egg (a technique known        as ICSI, intracytoplasmic sperm injection). And it may be done for the        (proximate) purpose (WHY) of initiating a pregnancy, in turn for the (ultimate)        purpose of providing a child for an infertile couple; or it may be done        for the (proximate) purpose of providing living human embryos for basic        research on normal and abnormal embryological development, in turn for        the (ultimate) purposes of understanding human development or of discovering        cures for diseases and producing tissues for regenerative medicine. Though        the technique used or the purposes served may differ, in the crucial respect        the act remains the same and bears a common intrinsic meaning: a human        zygote, the first stage of a new human being, is intentionally produced        outside the body with technical assistance.As it happens, this fact is more or less accurately reflected in the descriptive        terminology used for IVF. Interestingly enough, unlike the situation with        cloning, no one distinguishes between "reproductive IVF" and        "therapeutic IVF" or "research IVF," naming the activity        or deed after the motive or purpose of the agent. This may reflect the        accidental fact that IVF was initiated solely (or mainly) by people who        were interested in using it to produce live-born children for infertile        couples; the research use of "spare" embryos created by IVF        came only later. But it happens that this common name is also descriptively        apt: the deed is fertilization of egg by sperm, creating a living human        zygote, the first stage of the development of a new human being. It should be noted that, although we began by trying to describe the deed        rather than the product of the deed, the two aspects merged necessarily.        The meaning of the act of "fertilization" falls forward onto        the nature of the "object" that fertilization creates: the fertilized        egg or zygote or earliest embryo.**1**(By contrast, there is nothing in the name of the technique, "intracytoplasmic        sperm injection," that even hints at the immediate result or goal        of the intended injection.) Similar attention to the nature of the product        may turn out to be indispensable for a proper characterization of the        activity of cloning.Cloning: Toward an Appropriate TerminologyThough much of the terminological confusion and controversy concerns the        way to describe the different kinds of cloning practices that are envisioned,        the term "cloning" itself is not without its own ambiguities.        A "clone" (noun, from the Greek klon, "twig") refers        to a group of genetically identical molecules, cells, or organisms descended        from a single common ancestor, as well as to any        one of the one or more individual organisms        that have descended asexually from a common ancestor. "To clone"(verb) is to duplicate or create a genetic duplicate(s) of a molecule,        cell, or individual organism. The replication of DNA fragments in the        laboratory is called "DNA cloning." The propagation of single-cell        lines in tissue culture is sometimes referred to as "cell cloning."Asexual propagations of bacteria or of plants by means of cuttings are        instances of organismal cloning. Cloning of higher organisms is more complex:        all cloning of vertebrate organisms must begin at the embryonic stages.        Contrary to what some people imagine, cloning of amphibians or mammals        (including human beings) is not the "Xeroxing" of an adult organism.        In the sense relevant here, "cloning" is a mode of asexual reproduction        (parthenogenesis is another), the creation of a new individual not by        the chance union of egg and sperm (from female and male individuals, the        parents), but the creation of a new individual by some form of replication        of the genetic make-up of a single individual. (The essence of sexual        reproduction is not bodily intercourse but the fusion of male and female        germ cells; thus IVF, though it takes place outside the body, is-biologically        speaking-a form of sexual reproduction.) The WHAT of cloning is the activity        of producing a clone, an individual or group of individuals genetically        the same as the precursor that is being "replicated."2In much of the current public discussion, we encounter a distinction between        "reproductive" cloning and "therapeutic" cloning.        The distinction is based entirely on the differing goals (the WHY) of        the cloners: in the first case, the goal is the production of a cloned        baby, in the second case, the development of treatments for diseases (suffered        not by the clone, but by others). Both these terms have been criticized        by partisans of several sides of the debate, and for understandable reasons.        Some object to the term "reproductive" cloning used as a term        of distinction, because they argue that ALL cloning is reproductive: all        cloning intends and issues in the creation of a living human embryo, a        creature that is a new human being in the (its) earliest stage of development        or "reproduction." (This is a descriptive, not a normative point;        it does not necessarily imply that such a being        is fully human or "one of us," hence deserving of the moral        and social protection accorded "persons.")The fact that only some of these embryonic cloned humans are wanted for        baby-making purposes does not, in the view of these critics, alter this        fact about their being. Others object to the term "therapeutic" cloning for related        reasons. The act of cloning may be undertaken with healing motives. But        it is not itself an act of healing, nor does it issue in or effect a treatment        or a cure (compare, in this respect, what used to be called "therapeutic        abortion," an abortion undertaken in cases in which pregnancy was        life-threatening to the pregnant woman and where abortion was therefore        intended to save the woman's life). The prospective beneficiaries of any        acts of cloning are, at the moment, purely hypothetical. And if medical        treatments do eventually result, the embryonic clone produced in the process        will never be the beneficiary of any therapy. On the contrary, this sort        of cloning actually sacrifices the being that results from the act of        cloning. To avoid the misleading implications of calling any cloning "therapeutic,"we might prefer the term "research" cloning, again indicating        the purpose of the activity. Yet others find fault with this replacement.        Because it appears to be a deliberate substitution for "therapeutic"cloning, it seems to imply that the scientists have abandoned the pursuit        of medical cure in favor of research (as an end in itself). Believing        that creating embryos just for research would seem to be less justifiable        than creating them with healing motives, these critics want to avoid the        impression that scientists want to experiment on new life just to satisfy        their curiosity. (The same argument applies with equal force against the        term "experimental cloning.")Some proponents of "therapeutic" cloning-the use of quotation        marks are intended only to indicate that there is dispute over whether        this term is apt-also now complain about the term, but not about the adjective.        Though they originally coined and used the term, they now want to shed        the term "cloning," fearing that the opprobrium of the latter        will weigh against the activity itself. Cloning, they insist, should be        reserved for the activity that creates live-born cloned babies; it should        not apply to the initial act that starts the process, which they would        rather call "somatic cell nuclear transfer" or "nuclear        transplantation." While not inaccurate, such a substitution is, as        the sequel suggests, also problematic. To escape from the bad connotations of "cloning," and to stay        closer to scientific terminology, scientists now seem to prefer the term        human "somatic cell nuclear transfer" (SCNT) as the name for        the activity they support. But accurate though it may be as a description        of the technique that is used to produce the embryonic clone (HOW), it        does not touch the nature of the deed itself (WHAT). The WHAT is "the        creation of a living-human-zygote (or embryo) that is genetically virtually        identical to the donor organism," a fact or meaning not captured        in the name for the HOW, the transfer of a somatic cell nucleus (into        an unfertilized egg whose own nucleus has been removed or inactivated).        This reduction of act to its mechanism is roughly analogous to describing        walking as "sequential alternate leg advancement" (SALA). In        fact, it is not even as good as this, for, as a name, SCNT is not a fully        accurate description even of the technique itself. Not only does it make        no reference to the intended and direct result of the deed of nuclear        transfer. It also omits mention of the fact that the recipient of the        transferred nucleus is an EGG (rather than another kind of) cell, which        then can be made to behave as if it were a zygote produced by fertilization.        The further amendments, "somatic cell nuclear transfer for        stem cell research" or "nuclear transplantation        for regenerative medicine"only compound the difficulty, mixing in the purpose of the activity (WHY)        with its technique (HOW), thus further obscuring the immediate meaning        (the WHAT) of the act itself, the creation of a living human embryo of        a certain type, i.e., cloned. There is a further difficulty with these expressions. All these descriptions        of the activities that the scientists wish to pursue omit all reference        not only to cloning but also to embryos (and human embryos). Indeed, some        are insisting that the immediate product of somatic cell nuclear transfer        is not an "embryo" but rather "an activated cell,"and that the subsequent stages of development should not be called embryos        but "clumps of cells" or "activated cells."Once again, we see how the meaning of the act, and hence its proper name        and description, falls forward onto the nature of the product. We come        then at the question of names from a consideration of the outcome.The initial product of SCNT is, to be sure, a cell. But it is no ordinary        cell. It is a cell that resembles and can be made to act like a fertilized        egg, a cell that not only has the full complement of chromosomes but,        unlike a somatic cell, is capable of developing into a new organism. In        other words, it is a zygote or a zygote-like being. It is, to be sure,        not just a cell but an active cell, or, at least, it can be activated,        say by electric shocking. But to name it "activated cell" is        much too vague to describe the activity of which it is capable. For once        stimulated, the activity of this "cell" produced by SCNT is        nothing other than human embryological development, initiated and directed        by the cell itself. The processes of cellular growth, chromosomal replication,        cell division, and (ultimately) differentiation into the tissues and organs        of the organism are coordinated processes under the governance of the        immanent plan for such development encoded in the cell's genetic material.        In other words, the "cell" is an organism in its germinal stage,        and its activities are those of an integrated and self-developing whole.For the same reason, it is inaccurate to describe the next few stages        of this developing being as "clumps of cells." Yes, there will        be 2, then 4, then 8 cells "clumped" together, and the 100-200        cell spherical stage called the blastocyst may be externallydescribed as a "ball of cells" or a "clump of cells."But this ball or clump is not just a heap or an aggregate; it is a primordial        and unfolding whole that functions as a whole and that is in the process        of developing into a mature whole being, if nothing interferes (and if        it is implanted). It is, in short, an embryo. That it can be interfered        with to prevent it from reaching that maturity does not alter our assessment        of what it is, here and now, any more than the eating of a sprouting acorn        by a squirrel denies that the acorn is a nascent or embryonic oak tree.        The fact of the matter seems to be this: the product of somatic cell nuclear        transfer is a living (one-celled) human embryo. The immediate intention        of transferring the nucleus is precisely to produce just such a being:        one that is alive (rather than non-living), one that is human (rather        than non-human or animal), and one that is an embryo, a developing being        capable of unfolding into an articulated organismic whole (rather than        just a somatic cell capable only of replication into more of the same        cell type). This is the intended product of SCNT, whether the motive or        purpose is baby-making with the embryo or scientific research to be conducted        on the embryo. Also, the blastocyst that develops from this one-celled        embryo will be the same being, whether it is then transferred to a woman's        uterus to begin a pregnancy or it is used as a source of stem cells for        research and possible therapy for others. The name "SCNT" also omits one further, crucial, and indeed        essential aspect of this activity and this product. The human embryo thus        produced will be a clone: a genetic copy (rather, a nearcopy) of the individual that was the source of the transferred nucleus,        hence an embryonic clone of the donor. There is, to be sure, much discussion        about how close the genetic relation is between donor and embryonic clone,        and what that bodes for the phenotypic identity of the clone. The environment        in which the donor came to be and lives surely differs from the one in        which the cloned embryo may develop (if it does develop). There may be        imprinting differences in gene expression early on that may affect the        degree of genetic identity. There is also the matter of the mitochondrial        genes, some 13 or so genes out of a total of some 30,000, which are inherited        from the female source of the egg (the clone would be genetically identical        only in those cases in which the same woman donated both egg and somatic        cell nucleus, to produce an embryonic clone of herself). Yet the goal        in this process is in fact an embryo or child that is genetically virtually        identical to the donor; otherwise there would be no reason to create the        embryo by SCNT rather than by ordinary IVF. This analysis leads to the following conclusion regarding the terms most        descriptive of the facts of the matter: WHAT: The term "human cloning" means the asexual production        of a new human organism-at whatever stage of development-that is genetically        virtually identical to an already existing or previously existing human        being.HOW: It is currently accomplished by introducing the nuclear material        of a human somatic cell into an oocyte whose own nucleus has been removed        or inactivated, to produce a living organism that has a human genetic        constitution virtually identical to the donor of the somatic cell.WHY: This same activity may be undertaken for purposes of baby-making        or for purposes of scientific and medical investigation and use. Human "reproductive" cloning and human "therapeutic"/"research"cloning should now be understood to mean the following: 1. "Reproductive" cloning:Creation of a living cloned human embryo, produced for the (proximate)        purpose of initiating a pregnancy that will issue in a child who will        be a genetic (near-)twin of a previously existing individual, with the        ultimate goal of satisfying one or another parental desire to have such        a child. 2. "Therapeutic"/"Research"cloning: Creation of a living cloned human embryo,        produced for the (proximate) purpose of using it in research or for extracting        its stem cells, with the ultimate goals of gaining scientific knowledge        of normal and abnormal development and of developing cures for human diseases.        What Does This Mean for the Council's Work?        Where does this linguistic analysis leave us? One possibility is to adopt        the dominant terminology ("reproductive" and "therapeutic"or "research"), given that we have little hope of changing the        current usage. We could make perfectly clear what these terms mean in        our hands, so that there will be no ambiguity. At the same time, our analysis        might serve to chasten people regarding the power and pitfalls of the        terminology, including the ones we are adopting. The analysis would also        alert people to the danger of euphemism and misleading speech. A second possibility is to attempt a better way of describing these matters,        perhaps even coining some new terms. No one should underestimate the difficulty        of the task, or exaggerate the chances that our terms, even if better,        could gain currency. But the invitation is open to anyone who would like        to make a proposal. 
1. Though not needed for present purposes, a more careful        analysis of the WHAT of this activity would distinguish between the activity        itself and the product that results from it. Unlike non-productive activities,        for example dancing ("How can we know the dancer from the dance?"),        the work (activity) of making and producing issues in separable objects        or works (products). Although shoemaking completes itself in the production        of a shoe, the shoe as RESULT is distinct from the ACTIVITY of shoemaking.        Similarly, though fertilization is an activity that is intelligible only        as issuing in a fertilized egg, the now-fertile egg as RESULT or PRODUCT        stands apart from the deed of IVF.  2. Although cloning, like fertilization, is responsible        for bringing forth a new organism, the activities are named in very different        ways, yet in each case emphasizing the inner intention of the activity.        "Fertilization" describes the activity in terms of the capacitation        of the egg, as a result of which development begins. "Cloning"describes the activity in terms of the relation between the progenitor        and the product. In cloning by somatic cell nuclear transfer, the egg,        though it is activated as if it were fertilized, is not cloned; cloned        rather is the donor from whom the nucleus was taken; and the resulting        organism (at all stages of development) is a clone of the donor. The name        of the activity, "cloning," even more than "in vitro fertilization,"refers to the *product* of the activity, an identical (or near-identical)        thing. |