Flonicamid Dietary Exposure Assessment DP Barcode: D397279



### Page 1 of 13 **UNITED STA TES ENVIRONMENTA**  **L PROTECTION A GENCY**  **WA SHINGTON, D.C. 20460**  **OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION**  

### MEMORANDUM DATE: September 27, 2012 S UBJECT: **Revised Flonicamid**  Chronic Aggregate Dietary (Food and Drinking Water)

Exposure and Risk Assessments for a n IR
- 4 Section 3 Registration Action on Berry L ow - Growing Subgroup 13
- 07G, Cucumber for Greenhouse Use Only , and Rapeseed Sub
- g roup 20A. **PC Code:** 128016 **DP Barcode:** D39 7279 **Decision No.:** 457726 **Registration No s**  **. :**  71512
- 9, 71512
- 10 **Petition No.:** 1E7942 **Regulatory Action:** Section 3 Registration **Assessment Type:** Single Chemical **Case No.:** NA **T XR No.:**  NA **CAS No.:** 158062
- 67
- 0 **MRID No.:** NA **40 CFR:** § 180.613 

### REVI EWER: Cassi L . Walls, Ph.D., Senior Biologist

Risk Assessment Branch III Health Effects Division (7509P) THROUGH: Julie Van Alstine, MPH, Environmental Health Scientist

Amelia M. Acierto , Chemist Dietary Exposure Science Advisory Council (DESAC) Health Effects Division (7509 P ) Jeff Dawson , Acting Branch Chief Risk Assessment Branch III Health Effects Division (7509P) TO: Barry

O’Keefe , Risk Assessor Risk Assessment Branch III Health Effects Divis ion (7509P) **Executive Summary** C hronic aggregate dietary (food and drinking water) exposure and risk assessment s w ere conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM
- FCID) Version 3.16 , which uses food consumption data from the U.S. Department of Agriculture’s National Health and Nutrition Examination Survey , What We Eat in America, (NHANES/WWEI A). This dietary survey was conducted from 2003 to 2008. The anal ys is was performed to suppo rt a petition for tolerances in conjunction with an IR
- 4 petitionFlonicamid Dietary Exposure Assessment DP Barcode: D397279



### Page 2 of 13 for a Section 3 registration for the new uses of flonicamid on berry low
- g rowing subgroup 13
- 07G, cucumber (for greenhouse use only ), and rapeseed s ub
- group 20A. Chronic Dietary

Exposure Re sults and Characterization Tolerance
- level residues combined with 100% crop treated were used to determine the chronic dietary exposure and risk estimates. Drinking water was incorporated directly into the dietary assessment. Th e chronic dietary exposur e estimates for food and drinking water are below HED’s level of concern for the general U.S. population [11 % of the chronic population adjusted dose (cPAD) ] and t he most highly exposed population subgroup , children 1

– 2 y ears old (28 % of the cPAD). Acute Dietary

Exposure Results and Characterization An acute dietary

risk assessment was not performed as flonicamid has no acute toxicological endpoint. Cancer Dietary

Exposure Results and Characterization A cancer dietary

assessment was not conducted as flonicamid has been determined to be “ Suggestive Evidence of Carcinogenicit y, but Not Sufficient to Assess Human Carcinogenic Potential ”. **I. Introduction**  Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population adjusted dose (PAD). Th e PAD is equivalent to point of de parture (POD) (e.g., NOAEL, LOAEL ) divided by the required uncertainty

or safet y factors. For non
- cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. HED is generall y concerned when estimated cancer risk exceeds one in one million. References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Gui de,” 21
- JUN
- 2000, web link: http://www.epa.gov/fedrgstr/EPA
- PEST/2000/July /Day
12/6061.pdf

; or see SOP 99.6 (20
- AUG
- 1999). The most recent dietary

risk assessment for flonicamid was conducted b y Amelia Acierto ( 08
- NOV
- 2007 , DP Number 343466 ). **II. Residue Information** Flonicamid Dietary Exposure Assessment DP Barcode: D397279



### Page 3 of 13 Flonicamid Use: Flonicamid is a Group 9C insecticide (selective feeding blocker) registered for the control of a variet y of aphid pests and the suppression of a variety of non
- aphid pests . Tolerances for registered com modities can be found in 40 CFR §180.613 . The tolerances that are currently being recommended are listed in Table 1, below. The residue s of concern in/on plants are the parent flonicamid and i ts major metabolites , TFNA
- AM, TFNA , and TFNG; and in /on ruminants are the parent and its metabolites TFNA
- AM and TFNA. Residue Data used for Chronic Assessments: The r esidue levels used in the chronic assessment were the tolerance levels for plant commodities established under 40 CFR § 180.613 and the HED recommended tolerance levels based on the crop field trials for the proposed crops
. T he livestock commodity tole rances are unchanged from the previous assessment
. Table 1 presents a summary of the tolerance residue levels used in the chronic assessment
. Estimated concentrations of flonicamid in drinking water from the proposed use s w ere provided by EFED and incorporated directl y into the chronic assessment. The assessments used 100% crop treated. **Table 1. Tolerance Summary for Proposed Uses of Flonicam id**  **Comm odity**  **Proposed Tolerance (ppm)**  **HED**

**Recommended Tolerance**  **(ppm) Comments** 

**(correct commodity definition)**  Berry, low

growing, subgroup 13
- 07G 1.4 1
. 5 Rapeseed subgroup 20A 1.5 1.5 Vegetable, cucurbit, group 9 0.4 1.5 Vegetable, cucurbit, group 9 

### Processing Factors : Separate tolerances were established for dried potatoes, tomato paste, and tomato puree based on processing studies. The processing factor was s et to 1.0 for these commodities. DEEM default processing factors were used for the other processed commodities for which default processing factors a re available. **III. Drinking Water**  The drinking water residues used in the dietary risk assessment were provided by the Environmental Fate and Effects Division (EFED) in the following memorandum: “ Drinking Water Assessment to Assess Flonicamid Use on Low Growing Berries Subgroup 13
- 07G, Gre enhouse Cucumbers, and Rapeseed 20A ” ( J. Hetrick , D396906, 4/25/12 )
. Water residues were incorporated in the DEEM
- FCID into the food categories “water, direct, all sources” andFlonicamid Dietary Exposure Assessment DP Barcode: D397279



### Page 4 of 13 “water, indirect, all sources.” No monitoring data of flonicamid were availa ble to EFED
. The estimated drinking water concentrations from s urface water sources were calculated using th e Tier II PRZM ( Pesticide Root Zone Model) and EXAMS ( Exposure Analysis Modeling Sy stem). PR ZM is used to simulate pesticide transport as a result of runoff and erosion from an agricultural field and EXAMS estimates environmental fate and transport of pesticides in surface water. The values generated b y the models for drinking water were multipl ied by a national crop area factor (PCA), which accounts for the fact that it is unlikely for any basin to be completely

planted to agricultural crops. Ground water concentrations were estimated using the Ti er I SCI
- GROW M odel. The model and its descript ion are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/
. Flonicamid may be applied by

aerial , ground , or chemigation as per the label s for this product
. This memo only addresses the estimations of parent flonicamid and its major metabolites, TFNG, TFNA, TFNA
- OH, TFNA
- AM , and TFNG
AM
. Based on modeling results, the estimated concentration of flonicamid and its degradation products is 1.9 μ g /L (ppb) for the 1 in 10 ye ar annual mean concentration (non
- cancer chronic)
. This estimate is based on three aerial applications at the rate of 0.089 lb ai/acre to potatoes in Maine using a PCA factor of 0.87. Both the acute and chronic estimated concentrations for flonicamid in ground water using the SCI GROW (version 2.3) M odel are 1.32 x 10 - 3 

### μg /L (ppb) for the combined residues
. The surface water value of 1.9 ppb was used in the dietary assessment because the surface water estimate is greater than the ground water estimate. **IV. DEEM**  **- FCIDTM Program and Consumption Information**  Flonicamid chronic dietary exposure assessment was conducted using the Dietary Exposure Evaluation Model software with the Food Commodity I ntake Database DEEM
- FCID, Version 3.16, which incorporates consumption data from USDA’s NHANES/WWEIA. This dietary survey was conducted from 2003 to 2008. The data are based on the reported consumption of more than 20,000 individuals over two non - consecutive survey day s. Foods “as consumed” (e.g., apple pie) are linked to EPA
- defined food commodities (e.g. , apples, peeled fruit
- cooked; fresh or N/S; baked; or wheat flour
- cooked; fresh or N/S, baked) using publicly available recipe tra nslation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption e vents. Based on anal ys is of the 1994
- 96, 98 CSFII consumption data, which took into account dietary patterns and survey

respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. populati on, all infants (<1 y ear old), children 1
- 2, children 3
- 5, children 6
- 12, y outh 13
- 19, adults 20
- 49, females 13
- 49, and adults 50+ y ears old.Flonicamid Dietary Exposure Assessment DP Barcode: D397279



### Page 5 of 13 For chronic dietary

exposure assessment, an estimate of the residue level in each food or food
form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average dail y consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the resi due intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg bod y weight/day and as a percent of the cPAD. This procedure is performed for each populati on subgroup. **V. Toxicological Information**  The toxicity

database for flonicamid was evaluated by HED's Toxicology

Team on 9/30/2004. The t eam selected endpoints and evaluated for FQPA concerns based on the potential hazard and exposure data for flonicami d and determined that there was no need for an additional safet y factor for the protection of infants and children. Flonicamid is classified to be category “Suggestive Evidence of Carcinogenicit y, but Not Sufficient to Assess Human Carcinogenic Potential, ” according to the EPA Draft Guidelines for Carcinogen Risk Assessment dated July , 1999; therefore, a cancer assessment is not necessary
. HED’s current toxicology team has reevaluated the endpoints and determined they are acceptable and applicable for risk assessment purposes. **Table 2. Summary of Dose and Toxicological Endpoint Selection Relative to Use in Dietary Hum an Health Risk**  **Assessment for Flonicam id**  **Exposure Scenario**  **Dose (m g/kg/day)**  **UF FQPA Safety Factor and**  **Level of Concern for Risk Assessment**  **Endpoint for Risk Assessment Acute Dietary**  general population including infants and children N/A N/A N/A
**Chronic Dietary** (All populations) NOAEL= 4.0 mg/kg/day UF = 100 **cPAD** = **0.04 m g/kg/day**  FQPA SF = 1x **cPAD** = Chronic RfD FQPA SF = 0.04 mg/kg/day 2
- Gen reproduction study in the

rat. Parental LOAEL = 22 mg/kg/day based on increased kidney weights, kidney hyaline deposition, increased blood serum LH (F1 females). **Cancer** (oral, dermal, inhalation) Classified as " Suggestive Evidence of Carcinogenicity, but Not Sufficient to Assess Human Carcinogenic Potential " N/A N/A

UF = uncertainty factor, FQPA SF = Special FQPA safety factor, NOEL = no observed adverse effect level, LOAEL = low est observed adverse effect level, cPAD = chronic populatio n , adjusted dose, Rfd = reference dose, N/A = not applicable. 

### V **I .**  **Results/Discussion**Flonicamid Dietary Exposure Assessment DP Barcode: D397279



### Page 6 of 13 As stated above, for chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM
- FCI DTM anal ys es estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table 3 below are for the general U.S. Population, all infants (<1 y ear old), children 1
- 2, children 3
- 5, children 6
- 12, y outh 13
- 19, females 13
- 49, adults 20
- 49, and adults 50+ years. Results of Chronic Dietary (Food and Drinking Water) Exposure Analy sis The resu lts of the chronic dietary (food and drinking water) exposure anal ysis are reported in Table 3 below. The chronic dietary

(food and drinking water) exposure to flonicamid is below HED’s level of concern for the general U.S. population and all popula tion subgroups. The chronic dietary exposure estimates are 1 1 % cPAD for the general U.S. population and 2 5 % cPAD for children 1
- 2 y ears old, the most highly exposed population subgroup. **Table 3. Summary of Dietary (Food and Drinking Water) Exposure an**  **d Risk for Flonicam id**  **1 Population Subgroup**  **cPAD (m**  **g/kg/day) Exposure (mg/kg/day)**  **% cPAD**

**DEEM -**  **FCID DEEM**  **- FCID**  General U.S. Population

0.04 0.004455 1 1 All Infants (< 1 year old) 0.006272 1 6 **Children 1 -**  **2 years old**  **0.011236 2**  **8** Children 3
- 5 y ears old 0.008413 21 Children 6
- 12 y ears old 0.004999 1 1 Youth 13
- 19 y ears old 0.003184 8 Ad ults 20
- 49 y ears old 0.003864 10 Fem ales 13
- 49 y ears old 0.003962 10 Ad ults 50
- 99 years old 0.004270 11 1 The population with the highest exposure is in bold 

### VI **I .**  **Characterization of Inputs/Outputs** The chroni c dietary

exposure anal ys is is considered to be conservative . As a result, HED is confident that exposure is not underestimated to the U.S. population or any population subgroup. Further refinements could be made; however, they are not necessary

at the present time. **VII I**  **. Conclusions**  The chronic dietary

exposure assessment was conducted for the proposed uses on greenhouse cucumber, low gr owing berries, rapeseed, and drinking water. A conservative assessment was conducted using tolerance residue values and 100% crop treated . Estimated concentrations of flonicamid in drinking water from the proposed uses were provided b y EFED and incorpora tedFlonicamid Dietary Exposure Assessment DP Barcode: D397279



### Page 7 of 13 directly into the chronic assessments. The chronic dietary

(food and drinking water) exposure to flonicamid is below HED’s level of concern for the general U.S. population and all population subgroups. The chronic dietary exposure estimates are 1 1 % cPAD for the general U.S. population and 2 8 % cPAD for children 1
- 2 y ears old, the most highly exposed population subgroup. **IX. List of Attachments**  Attachment 1: Chronic Food and Water Residue Input File. Attachment 2: Chronic Results File.Flonicamid Dietary Exposure Assessment DP Barcode: D397279



### Page 8 of 13 **A TTACHMENT**  

### 1. **DEEM**  **- FCID**  **C HRONIC**  

### R **ESIDUE** 

### I **NPUT** 

### F **ILE** 

### . Filename: C: \ Documents and Settings \ cwalls \ My Documents \ Cassi \ HED \ Flonicamid \ FLONICAMID050712.R08 Chemical: FLONICAMID RfD(Chronic): .04 mg/kg bw/day NOEL(Chronic): 4 mg/kg bw/day RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 08
- 23 - 2012/09:49:14 Program ver. 3.16, 03
- 08 - d Comment: CHRONIC ONLY

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101050000 1A B Beet, garden, roots 0.600000 1.000 1.000 0101050001 1AB Beet, garden, roots - babyfood 0.600000 1.000 1.000 0101067000 1AB Burdock 0.600000 1.000 1.000 0101078000 1AB Carrot 0.600000 1.000 1.000 0101078001 1AB Carrot - babyfood 0.600000 1.000 1.000 0101079000 1AB Carrot, juice 0.600000 1.000 1.000 0101084000 1AB Celeriac 0.600000 1 .000 1.000 0101100000 1AB Chicory, roots 0.600000 1.000 1.000 0101168000 1AB Ginseng, dried 0.600000 1.000 1.000 0101190000 1AB Horseradish 0.600000 1.000 1.000 0101250000 1AB Parsley, turnip rooted 0.600000 1.000 1.000 0101251000 1AB Parsnip 0.600000 1.000 1.000 0101251001 1AB Parsnip
- babyfood 0.600000 1.000 1.000 0101314000 1AB Radish, roots 0.600000 1.000 1.000 0101316000 1AB Radish, Oriental, roots 0.600000 1.000 1.000 0101327000 1AB Rutabaga 0.600000 1.000 1.000 0101331000 1AB Salsify, roots 0.600000 1.000 1.000 0101388000 1AB Turnip, roots 0.600000 1.000 1.000 0103015000 1CD Arrowroot, flour 0.200000 1.000 1.000 0103015001 1CD Arrowroot, flour - babyfood 0.200000 1.000 1.000 010301700 0 1CD Artichoke, Jerusalem 0.200000 1.000 1.000 0103082000 1CD Cassava 0.200000 1.000 1.000 0103082001 1CD Cassava - babyfood 0.200000 1.000 1.000 0103139000 1CD Dasheen , corm 0.200000 1.000 1.000 0103166000 1CD Ginger 0.200000 1.000 1.000 0103166001 1CD Ginger
- babyfood 0.200000 1.000 1.000 0103167000 1CD Ginger, dried 0.200000 1.000 1.000 0103296000 1C Potato, chips 0.200000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.400000 1.000 1.000 0103297001 1C Potato, dry (granules/ flakes)
- b 0.400000 1.000 1.00 0 0103298000 1C Potato, flour 0.400000 1.000 1.000 0103298001 1C Potato, flour - babyfood 0.400000 1.000 1.000 0103299000 1C Potato, tuber, w/peel 0.200000 1.000 1.000 0103299001 1C Potat o, tuber, w/peel
- babyfood 0.200000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.200000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel
- babyfood 0.200000 1.000 1.000 0103366000 1CD Sweet potato 0.200000 1.000 1.000 0103366001 1CD Sweet potato - babyfood 0.200000 1.000 1.000 0103371000 1CD Tanier, corm 0.200000 1.000 1.000 0103387000 1CD Turmeric 0.200000 1.000 1. 000 0103406000 1CD Yam, true 0.200000 1.000 1.000 0103407000 1CD Yam bean 0.200000 1.000 1.000 0200315000 2 Radish, tops 16.000000 1.000 1.000 0401005000 4A Ama ranth, leafy 4.000000 1.000 1.000 0401018000 4A Arugula 4.000000 1.000 1.000 0401104000 4A Chrysanthemum, garland 4.000000 1.000 1.000 0401133000 4A Cress, garden 4.000000 1.000 1.000 0401134000 4A Cress, upland 4.000000 1.000 1.000Flonicamid Dietary Exposure Assessment DP Barcode: D397279



### Page 9 of 13 0401138000 4A Dandelion, leaves 4.000000 1.000 1.000 0401150000 4A Endive 4.000000 1.000 1.000 0401204000 4A Lettuce, head 4.000000 1.000 1.000 0401205000 4A Lettuce, leaf 4.000000 1.000 1.000 0401248000 4A Parsley, leaves 4.000000 1.000 1.000 0401313000 4A Radicchio 4.000000 1.000 1.000 0401355000 4A Spinach 9.000000 1.000 1.000 0401355001 4A Spinach
- babyfood 9.000000 1.000 1.000 0402076000 4B Cardoon 4.000000 1.000 1.000 0402085000 4B Celery 4.000000 1.000 1.000 0402085001 4B Celery - babyfood 4.000000 1.000 1.000 0402086000 4B Celery, juice 4.000000 1.000 1.000 0402087000 4B Celtuce 4.000000 1.000 1.000 0402152000 4B Fennel, Florence 4.000000 1.000 1.000 0402322000 4B Rhubarb 4.000000 1.000 1.000 0402367000 4B Swiss chard 4.000000 1.000 1.000 0501061000 5A Broccoli 1.500000 1.000 1.000 0501061001 5A Broccoli
- babyfood 1.500000 1.000 1.000 0501062000 5A Broccol i, Chinese 1.500000 1.000 1.000 0501064000 5A Brussels sprouts 1.500000 1.000 1.000 0501069000 5A Cabbage 1.500000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 1.500000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 1.500000 1.000 1.000 0501083000 5A Cauliflower 1.500000 1.000 1.000 0501196000 5A Kohlrabi 1.500000 1.000 1.00 0 0502063000 5B Broccoli raab 16.000000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok choy 16.000000 1.000 1.000 0502117000 5B Collards 16.000000 1.000 1.000 0502194000 5B Kale 16.000000 1.000 1.000 0502229000 5B Mustard greens 16.000000 1.000 1.000 0502318000 5B Rape greens 16.000000 1.000 1.000 0502389000 5B Turnip, greens 16.000000 1.000 1.000 0801374000 8A Tomatillo 0.400000 1.000 1.000 0801375000 8A Tomato 0.400000 1.000 1.000 0801375001 8A Tomato - babyfood 0.400000 1.000 1.000 0801376000 8A Tomato, paste 2.000000 1.000 1.000 0801376001 8A Tomato, paste - babyfood 2.000000 1.000 1.000 0801377000 8A Tomato, puree 0.500000 1.000 1.000 0801377001 8A T omato, puree - babyfood 0.500000 1.000 1.000 0801378000 8A Tomato, dried 0.400000 14.300 1.000 0801378001 8A Tomato, dried
- babyfood 0.400000 14.300 1.000 0801379000 8A Tomato, juice 0.400000 1.500 1.000 0802148000 8BC Eggplant 0.400000 1.000 1.000 0802234000 8BC Okra 0.400000 1.000 1.000 0802270000 8B Pepper, bell 0.400000 1.000 1.000 0802270001 8B Pepper, bell - babyfood 0.400000 1.000 1.000 0802271000 8B Pepper, bell, dried 0.400000 1.000 1.000 0802271001 8B Pepper, bell, dried
- babyfood 0.400000 1.000 1.000 0802272000 8BC Pepper, nonbell 0.400000 1.000 1.000 0802272001 8BC Pepper, nonbell - babyfood 0.400000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 0.400000 1.000 1.000 0901075000 9A Cantaloupe 1.500000 1.000 1.000 0901187000 9A Honeydew melon 1.500000 1.000 1.000 0901399000 9A Watermelon 1.500000 1.000 1.000 0901400000 9A Watermelon, juice 1.500000 1.0 00 1.000 0902021000 9B Balsam pear 1.500000 1.000 1.000 0902088000 9B Chayote, fruit 1.500000 1.000 1.000 0902102000 9B Chinese waxgourd 1.500000 1.000 1.000 0902135000 9B Cucumber 1.500000 1.000 1.000 0902308000 9B Pumpkin 1.500000 1.000 1.000 0902309000 9B Pumpkin, seed 1.500000 1.000 1.000 0902356000 9B Squash, summer 1.500000 1.000 1.000Flonicamid Dietary Exposure Assessment DP Barcode: D397279



### Page 10 of 13 0902356001 9B Squash, summer - babyfood 1.500000 1.000 1.000 0902357000 9B Squash, winter 1.500000 1.000 1.000 0902357001 9B Squash, winter
- babyfood 1.500000 1.000 1.000 1100007000 11 Apple, fruit with peel 0.200000 1.000 1.000 1100008000 11 Apple, peeled fruit 0.200000 1.000 1.000 1100008001 11 Apple, peeled fruit
- babyfood 0.200000 1.000 1.000 1100009000 11 Apple, dried 0.200000 8.000 1.000 1100009001 11 Apple, dried
- babyfood 0.200000 8.000 1.000 1100010000 11 Apple, juice 0.200000 1.300 1.000 1100010001 11 Apple, juice
- babyfo od 0.200000 1.300 1.000 1100011000 11 Apple, sauce 0.200000 1.000 1.000 1100011001 11 Apple, sauce - babyfood 0.200000 1.000 1.000 1100129000 11 Crabapple 0.200000 1.000 1.000 1100210000 11 Loquat 0.200000 1.000 1.000 1100266000 11 Pear 0.200000 1.000 1.000 1100266001 11 Pear - babyfood 0.200000 1.000 1.000 11002670 00 11 Pear, dried 0.200000 6.250 1.000 1100268000 11 Pear, juice 0.200000 1.000 1.000 1100268001 11 Pear, juice
- babyfood 0.200000 1.000 1.000 1100310000 11 Quince 0.200000 1.000 1.000 1201090000 12A Cherry 0.600000 1.000 1.000 1201090001 12A Cherry - babyfood 0.600000 1.000 1.000 1201091000 12A Cherry, juice 0.60000 0 1.500 1.000 1201091001 12A Cherry, juice
- babyfood 0.600000 1.500 1.000 1202012000 12B Apricot 0.600000 1.000 1.000 1202012001 12B Apricot
- babyfood 0.600000 1.000 1.000 120201 3000 12B Apricot, dried 0.600000 6.000 1.000 1202014000 12B Apricot, juice 0.600000 1.000 1.000 1202014001 12B Apricot, juice
- babyfood 0.600000 1.000 1.000 1202230000 12B Nectarine 0.600000 1.000 1.000 1202260000 12B Peach 0.600000 1.000 1.000 1202260001 12B Peach - babyfood 0.600000 1.000 1.000 1202261000 12B Peach, dried 0.600000 7.000 1.000 1202261001 12B Peach, dried
- babyfood 0.600000 7.000 1.000 1202262000 12B Peach, juice 0.600000 1.000 1.000 1202262001 12B Peach, juice
- babyfood 0.600000 1.000 1.000 1203285000 12C Plum 0.600000 1.000 1.000 1203285001 12C Plum - babyfood 0.600000 1.000 1.000 1203286000 12C Plum, prune, fresh 0.600000 1.000 1.000 1203286001 12C Plum, p rune, fresh - babyfood 0.600000 1.000 1.000 1203287000 12C Plum, prune, dried 0.600000 5.000 1.000 1203287001 12C Plum, prune, dried
- babyfood 0.600000 5.000 1.000 1203288000 12C Plum, prune, juice 0.600000 1.400 1.000 1203288001 12C Plum, prune, juice
- babyfood 0.600000 1.400 1.000 1307130000 13G Cranberry 1.500000 1.000 1.000 1307130001 13G Cranberry - babyfood 1.500000 1.000 1.00 0 1307131000 13G Cranberry, dried 1.500000 1.000 1.000 1307132000 13G Cranberry, juice 1.500000 1.100 1.000 1307132001 13G Cranberry, juice
- babyfood 1.500000 1.100 1.000 1307359000 13G Straw berry 1.500000 1.000 1.000 1307359001 13G Strawberry - babyfood 1.500000 1.000 1.000 1307360000 13G Strawberry, juice 1.500000 1.000 1.000 1307360001 13G Strawberry, juice
- babyfood 1.500000 1.000 1.000 2001163000 20A Flax seed, oil 1.500000 1.000 1.000 2001319000 20A Rapeseed, oil 1.500000 1.000 1.000 2001319001 20A Rapeseed, oil
- babyfood 1.500000 1.000 1. 000 2001336000 20A Sesame, seed 1.500000 1.000 1.000 2001336001 20A Sesame, seed - babyfood 1.500000 1.000 1.000 2001337000 20A Sesame, oil 1.500000 1.000 1.000 2001337001 20A Sesame, oil
- babyfood 1.500000 1.000 1.000 2003128000 20C Cottonseed, oil 0.500000 1.000 1.000 2003128001 20C Cottonseed, oil
- babyfood 0.500000 1.000 1.000Flonicamid Dietary Exposure Assessment DP Barcode: D397279



### Page 11 of 13 3100044000 31 Beef, meat 0.080000 1.000 1.000 3100044001 31 Beef, meat - babyfood 0.080000 1.000 1.000 3100045000 31 Beef, meat, dried 0.080000 1.920 1.000 3100046000 31 Beef, meat byproducts 0.080000 1.00 0 1.000 3100046001 31 Beef, meat byproducts - babyfood 0.080000 1.000 1.000 3100047000 31 Beef, fat 0.030000 1.000 1.000 3100047001 31 Beef, fat - babyfood 0.030000 1.000 1.000 3100048000 31 Beef, kidney 0.080000 1.000 1.000 3100049000 31 Beef, liver 0.080000 1.000 1.000 3100049001 31 Beef, liver
- babyfood 0.080000 1.000 1.000 3200169000 32 Goat, meat 0.080000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.080000 1.000 1.000 3200171000 32 Goat, fat 0.030000 1.000 1.000 3200172000 32 Goat, kidney 0.080000 1. 000 1.000 3200173000 32 Goat, liver 0.080000 1.000 1.000 3300189000 33 Horse, meat 0.080000 1.000 1.000 3500339000 35 Sheep, meat 0.080000 1.000 1.000 3500339001 3 5 Sheep, meat - babyfood 0.080000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.080000 1.000 1.000 3500341000 35 Sheep, fat 0.030000 1.000 1.000 3500341001 35 Sheep, fat - babyfood 0.030000 1.000 1.000 3500342000 35 Sheep, kidney 0.080000 1.000 1.000 3500343000 35 Sheep, liver 0.080000 1.000 1.000 3600222000 36 Milk, fat 0.030000 1.000 1.000 3600222001 36 Milk, fat
- baby food/infant formu 0.030000 1.000 1.000 3600223000 36 Milk, nonfat solids 0.030000 1.000 1.000 3600223001 36 Milk, nonfat solids
- baby food/in 0.030000 1.000 1.000 3600224000 36 Milk, water 0.030000 1.000 1.000 3600224001 36 Milk, water
- babyfood/infant form 0.030000 1.000 1.000 3600225001 36 Milk, sugar (lactose)
- baby food/ 0.030000 1.000 1.000 4000093000 40 Chicken, meat 0.030000 1.000 1.000 4000093001 40 Chicken, meat
- babyfood 0.030000 1.000 1.000 4000094000 40 Chicken, liver 0.030000 1.000 1.000 4000095000 40 Chicken, meat byproducts 0.030000 1.000 1.000 4000095001 40 Chicken, meat byproducts
- babyfoo 0.030000 1.000 1.000 4000096000 40 Chicken, fat 0.030000 1.000 1.000 4000096001 40 Chicken, fat
- babyfood 0.030000 1.000 1.000 4000097000 40 Chicken, skin 0.030000 1.000 1.000 4000097001 40 Chicken, skin
- babyfood 0.030000 1.000 1.000 5000382000 50 Turkey, meat 0.030000 1.000 1.000 5000382001 50 Turkey, meat - babyfood 0.030000 1.000 1.000 5000383000 50 Turkey, liver 0.030000 1.000 1.000 5000383001 50 Turkey, liver
- babyfood 0.030000 1.000 1.000 5000384000 50 Turkey, meat byproducts 0.030000 1.000 1.000 5000384001 50 Turkey, meat byproducts - babyfood 0.030000 1.000 1.000 5000385000 50 Turkey, fat 0.030000 1.000 1.000 5000385001 50 Turkey, fat - babyfood 0.030000 1.000 1.00 0 5000386000 50 Turkey, skin 0.030000 1.000 1.000 5000386001 50 Turkey, skin
- babyfood 0.030000 1.000 1.000 6000301000 60 Poultry, other, meat 0.030000 1.000 1.000 6000302000 60 Poult ry, other, liver 0.030000 1.000 1.000 6000303000 60 Poultry, other, meat byproducts 0.030000 1.000 1.000 6000304000 60 Poultry, other, fat 0.030000 1.000 1.000 6000305000 60 Poultry, other, skin 0.030000 1.000 1.000 7000145000 70 Egg, whole 0.040000 1.000 1.000 7000145001 70 Egg, whole - babyfood 0.040000 1.000 1.000 7000146000 70 Egg, white 0.040000 1.000 1.000 7000146001 70 Egg, white (solids)
- babyfood 0.040000 1.000 1.000 7000147000 70 Egg, yolk 0.040000 1.000 1.000 7000147001 70 Egg, yolk - babyfood 0.040000 1.000 1.000 8601000000 86A W ater, direct, all sources 0.001900 1.000 1.000 8602000000 86B Water, indirect, all sources 0.001900 1.000 1.000Flonicamid Dietary Exposure Assessment DP Barcode: D397279



### Page 12 of 13 9500188000 O Hop 7.000000 1.000 1.000Flonicamid Dietary Exposure Assessment DP Barcode: D397279



### Page 13 of 13 **Attachment 2: DEEM**  **- FCID Chronic Results**  U.S. EPA Ver. 3.16, 03 - 08 - d DEEM - FCID Chronic analysis for FLONICAMID NHANES 2003
- 2008 2 - day Residue file name: C: \ Documents and Settings \ cwa lls \ My Documents \ Cassi \ HED \ Flonicamid \ FLONICAMID050712.R08 Adjustment factor #2 NOT used. Analysis Date 09
- 27 - 2012/15:13:35 Residue file dated: 09
- 27 - 2012/15:12:49 Reference dose (RfD , Chronic) = .04 mg/kg bw/day COMMENT 1: CHRONIC ONLY

=============================================================================== Total exposure by population subgroup

---------------------------------------------------------------- --------------- Total Exposure

----------------------------------- Population mg/kg Percent of Subgrou p body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.004455 11.1% Hispanic 0 .004094 10.2% Non - Hisp
- White 0.004421 11.1% Non - Hisp
- Black 0.004612 11.5% Non - Hisp
- Other 0.005475 13.7% Nursi ng Infants 0.004389 11.0% Non - Nursing Infants 0.007113 17.8% Female 13+ PREG 0.004172 10.4% Children 1
- 6 0.009134 22.8% Children 7
- 12 0.004695 11.7% Male 13 - 19 0.003124 7.8% Female 13 - 19/NP 0.003246 8.1% Male 20+ 0.003698 9.2% Female 20+/NP 0.004334 10.8% Seniors 55+ 0.004270 10.7% All Infants 0.006272 15.7% Female 13 - 50 0.003950 9.9% Children 1
- 2 0.011236 28.1% Children 3
- 5 0.008413 21.0% Children 6
- 12 0.004999 12.5% Youth 13 - 19 0.003184 8.0% Adults 20 - 49 0.003864 9.7% Adults 50 - 99 0.004270 10.7% Female 13 - 49 0.003962 9.9%

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