Exhibit 10.322

|CONFIDENTIAL |  | REDACTED VERSION
|------------ |  | ----------------

[***] CERTAIN INFORMATION IN THIS EXHIBIT HAS BEEN OMITTED AND FILED SEPARATELY WITH THE COMMISSION. CONFIDENTIAL TREATMENT HAS BEEN REQUESTED WITH
RESPECT TO THE OMITTED PORTIONS

BLOOD SCREENING    HIV PROBE LICENSE AGREEMENT    EUROPEAN UNION    between    CHIRON CORPORATION    F. HOFFMANN-LA ROCHE LTD.    and    ROCHE
MOLECULAR SYSTEMS, INC.

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BLOOD SCREENING HIV PROBE LICENSE AGREEMENTEUROPEAN UNION    TABLE OF CONTENTS

|           |  |                                        |  | Page
|---------- |  | -------------------------------------- |  | ----
|RECITALS   |  |                                        |  | 1   
|ARTICLE 1  |  | DEFINITIONS                            |  | 1   
|ARTICLE 2  |  | LICENSE AND OPTION GRANTS              |  | 5   
|ARTICLE 3  |  | PAYMENTS, ROYALTIES                    |  | 7   
|ARTICLE 4  |  | RECORDS AND REPORTS                    |  | 7   
|ARTICLE 5  |  | OTHER ACTIONS                          |  | 9   
|ARTICLE 6  |  | REPRESENTATIONS AND WARRANTIES         |  | 10  
|ARTICLE 7  |  | TERM AND TERMINATION                   |  | 11  
|ARTICLE 8  |  | CONFIDENTIALITY                        |  | 13  
|ARTICLE 9  |  | INDEMNITY                              |  | 14  
|ARTICLE 10 |  | ALTERNATIVE DISPUTE RESOLUTION         |  | 15  
|ARTICLE 11 |  | MISCELLANEOUS                          |  | 15  
|ARTICLE 12 |  | FIELD RESTRICTIONS AND OTHER COVENANTS |  | 18  
|ARTICLE 13 |  | INFRINGEMENT BY THIRD PARTIES          |  | 19  
|ARTICLE 14 |  | OTHER EUROPEAN COMMUNITY PROVISIONS    |  | 20  
|EXHIBIT A: |  | COMPENSATION TO CHIRON                 |  |     
|EXHIBIT B: |  | CHIRON PATENT LIST                     |  |     
|EXHIBIT C: |  | ROCHE PATENT LIST                      |  |     
|EXHIBIT D: |  | CHIRON LICENSED PRODUCTS               |  |     
|EXHIBIT E: |  | FORM OF REPORT                         |  |     
|EXHIBIT F: |  | EXISTING LICENSES                      |  |     

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BLOOD SCREENING HIV PROBE LICENSE AGREEMENTEUROPEAN UNION

This agreement (hereinafter "Agreement") is made by and between CHIRON CORPORATION, a Delaware corporation, of 4560 Horton Street, Emeryville, California 94608
(hereinafter referred to as "CHIRON"), F. HOFFMANN-LA ROCHE LTD., a Swiss corporation, of Grenzacherstrasse 124, Basel, Switzerland (hereinafter referred to as "ROCHE PARENT"), and
ROCHE MOLECULAR SYSTEMS, INC., a Delaware corporation, of 1145 Atlantic Avenue, Suite 100, Alameda, California 94501 (hereinafter referred to as "RMS" and collectively with ROCHE PARENT,
"ROCHE").

BACKGROUND

WHEREAS, CHIRON and ROCHE currently own or control certain patent rights relating to the human immunodeficiency virus ("HIV"), as defined below.

WHEREAS,
CHIRON and ROCHE entered into that certain Settlement Agreement dated as of October 10, 2000 (the "Settlement Agreement") pertaining to the settlement of the certain
litigation matters described therein.

WHEREAS,
in consideration of and subject to the execution and delivery of the Settlement Agreement, CHIRON granted licenses to ROCHE under certain patent rights relating to HIV for use
in assays for the detection of nucleic acid sequences for use in Blood Screening, under that certain Blood Screening HIV Probe License Agreement dated as of January 1, 2001 (the "Original
License Agreement").

WHEREAS,
the parties wish to amend the Original License Agreement by entering into a separate license agreement containing terms and conditions mutually agreed upon by the parties for
the region of the European Union, all on the terms and conditions set forth herein.

NOW,
THEREFORE, in consideration of the above provisions and the mutual covenants contained herein, CHIRON and ROCHE hereby agree as follows:

ARTICLE 1  DEFINITIONS

In this Agreement the following words and phrases shall have the following meanings:

1.1   "ADR"
means Alternative Dispute Resolution in accordance with Article 10.

1.2   "Affiliate"
means an entity that directly, or indirectly through one or more intermediaries, controls or is controlled by or is under common control with, a specified
entity. For the purposes of this definition, "control" (including with correlative meanings, the terms "controlling", "controlled by" and "under common control with"), as applied to any entity, means:
(a) the possession, directly or indirectly, of the power to direct or cause the direction of the management and policies of that entity, whether through the ownership of voting securities or by
contract or otherwise; or (b) the ownership of at least fifty percent (50%) of the voting securities of that entity. Notwithstanding anything to the contrary contained herein, "Affiliate" shall
not include, in the case of CHIRON, Novartis AG or any Affiliate of Novartis AG, unless Novartis shall have acquired direct control of a majority of the Board of Directors of CHIRON. Notwithstanding
anything to the contrary contained herein, "Affiliate" shall not include, in the case of ROCHE, Genentech Inc. or any Affiliate of Genentech Inc., nor Chugai Pharmaceutical
Co., Ltd. or any Affiliate of Chugai Pharmaceutical Co., Ltd.

1.3   "Authorized
Distributor" means abona fide, unaffiliated distributor, but excluding any entity which is a Major IVD
Manufacturer (as defined below) that is not licensed in the Field (as defined below) under one or-more of the CHIRON Licensed Patents (as defined below) or is affiliated with, or directly
or indirectly controlled by, such a Major IVD Manufacturer, except to the extent that such unlicensed Major IVD Manufacturer or its Affiliates distributes CHIRON Licensed Products for

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ROCHE
or its Affiliates on a local country basis and in the same manner in which it distributes other diagnostic products for ROCHE or its Affiliates and ROCHE and its Affiliates are not otherwise
selling CHIRON Licensed Products in such country.

1.4   "Blood
Screening" means the commercial use of products that detect nucleic acid sequences(s) for: (a) the screening of blood, plasma or blood components intended
for transfusion; and (b) confirmatory or supplemental testing of the same samples otherwise screened for purposes described in Section 1.4(a).

1.5   "Calendar
Quarter" means the three (3) month period beginning January 1, April 1, July 1 or October 1.

1.6   "Calendar
Year" means January 1 through December 31.

1.7   "CHIRON
Future HIV Sequence Patent Rights" means any and all Valid Claims Directed to HIV of United States and foreign patents and patent applications: (a) which
are based upon inventions conceived or rights acquired[***](as defined below); (b) are not CHIRON Licensed Patents (as
defined below); (c) which claim HIV nucleic acid sequence(s) or a method to use (other than in the manufacture of peptides) or detect such sequences specifically; (d) which are owned by,
licensed to or otherwise controlled by CHIRON or its Affiliates, with rights to license or sublicense; and (e) with respect to which CHIRON has the right to grant the option provided for in
Section 2.4 of this Agreement. For purposes of this Agreement, an invention will be deemed to have been conceived if there is a patent, patent application, written invention disclosure
statement or other tangible document (whether or not witnessed) describing such invention.

1.8   "CHIRON
Licensed Patents" means Valid Claims Directed to HIV which cover the manufacture, use, sale, offer for sale or importation of a Products that are contained
within any of the following: (a) the patents and applications identified in Exhibit B and any continuation, continuation-in-part and divisional applications
therefrom; (b) any reissued or reexamined patents obtained from such patents and applications; (c) all foreign counterparts of such patents and applications; and (d) all future
patents and applications which are based on inventions conceived by CHIRON or its Affiliates on or before the Effective Date.

1.9   "CHIRON
Licensed Products" means current and future Products which are used by, or for, or sold under circumstances, and in jurisdictions, such that in the absence of
the license granted under Section 2.1 such use or sale would constitute an infringement of a Valid Claim of the CHIRON Licensed Patents, including without limitation the Products identified in
Exhibit D, as modified from time to time by mutual agreement of the parties.

1.10 "CHIRON
Non-HCV/HIV Analyte Patent Rights" means any and all Valid Claims of U.S. and foreign patents and patent applications: (a) which claim any
nucleic acid sequence(s) or transmissible disease-causing agent(s), other than HCV or HIV; (b) which is a blood borne, infectious disease or virus to the extent such Valid Claims cover the
detection of any nucleic acid sequence(s) or transmissible disease-causing agent(s) of such infectious disease or virus; (c) which are owned by, licensed to or otherwise controlled by CHIRON or
its Affiliates, with right to license or sublicense; and (d) with respect to which CHIRON has the right to grant the option provided for in Section 2.4 of this Agreement.

1.11 "CHIRON
Optioned Rights" means the CHIRON Future HIV Sequence Patent Rights and the CHIRON Non-HCV/HIV Analyte Patent Rights.

1.12 "Cross
Sales" or "Cross Selling" shall have the meaning specified in Section 12.3.

1.13 "Cross
Seller" means an End User that is engaged in Cross Selling.

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1.14 "Directed
to HIV" means that the claim or technology in question is directed to methods, compositions, reagents or kits specifically for use in nucleic
acid-based diagnostic assays for the detection of HIV nucleic acid sequence(s), or specifically for use in the manufacture of any compositions or reagents for use in, or manufacture of
nucleic acid-based diagnostic assays for detection of HIV nucleic acid sequence(s) (excluding, for example, PCR claims and technology and other methods for detection of nucleic acid
sequence(s) generally which involve nucleic acid amplification). The terminology "specifically for use" as used in this Section 1.14, is intended to exclude inventions suitable for use with
viruses or analytes other than HIV (including by way of example and not by way of limitation, inventions relating to PCR, or assay formats, improved expression systems, detectable labels,
instrumentation, packaging and the like), which shall not be considered "specifically for use" in HIV detection as contemplated by this Section 1.14 and shall therefore not be considered as
"Directed to HIV" hereunder.

1.15 "Earned
Royalty" and "Earned Royalty Amount" shall have the meanings specified in Paragraph 1 of Exhibit A.

1.16 "Effective
Date" means[***].

1.17 "End
User" means a person or entity who is a final purchaser of a Product, and whose use of a Product results in the Product's consumption, operation, destruction or
loss of activity.

1.18 "Field"
means Blood Screening and Plasma Fractionation.

1.19 "Foundational
Patents" means the CHIRON Licensed Patents identified in Exhibit B which are stated therein to be Foundational Patents.

1.20 "HIV"
means any viral isolate of the human immunodeficiency virus classified as HIV by the International Committee on the Taxonomy of Viruses (or any body that replaces
such Committee) or any subtype of such isolate and further includes any isolate that is at least forty percent (40%) homologous to any such isolate and of the same genomic type and substantially the
same genomic organization, any isolate that has a genome that either hybridizes to or is substantially identical to any such isolate or its compliment, and any defective or modified form of any of the
above isolates.

1.21 "HIV
Diagnostics Agreements" means that certain HIV Probe License and Option AgreementEuropean Union between CHIRON and ROCHE, dated as of the Effective
Date, and that certain HIV Probe License and Option Agreement between CHIRON and ROCHE dated October 10, 2000, each as amended from time to time.

1.22 "Infringing
Third Party Sales" means (a) as to Blood Screening, sales by a Major IVD Manufacturer of Products for use in Blood Screening, and (b) as to
Plasma Fractionation, sales or use by any third party for use in Plasma Fractionation, which in either case: (i) infringe one or more of the CHIRON Licensed Patents, or (b) as to which a
license under one or more of the CHIRON Licensed Patents has been granted, but as to which the licensee is not paying royalties thereunder.

1.23 "In VitroDiagnostics" means the commercial use of products that detect nucleic acid sequence(s) of HIV in individual
human specimens, including the use of such products for diagnosis, prognosis, monitoring or classification purposes, including without limitation use for Transplantation but specifically excluding use
for Blood Screening and Plasma Fractionation (without prejudice to the provisions of the HIV Diagnostics Agreements).

1.24 "In VitroDiagnostics End User" means an entity that purchases CHIRON Licensed Products for the primary purpose of In VitroDiagnostics.

1.25 "Licensed/Optioned
Patents" means the CHIRON Licensed Patents and the ROCHE Optioned Patents.

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1.26 "Major
IVD Manufacturer" means a commercial entity (and its Affiliates) that manufactures, sells and engages in other commercial activities with respect to In VitroDiagnostic products and has a significant
marketing presence in the Region. Major IVD Manufacturers include Abbott, Bayer, Johnson &
Johnson, Pasteur, Sanofi, Dade Behring, Organon Teknika, Becton Dickinson, bioMerieux, BioRad, Fujirebio, Beckman Coulter, Visible Genetics, Innogenetics, and PE Corporation and each of their
successors and assigns and any other entity which commands in the future at least an equivalent presence as measured by total product sales as do any of the foregoing entities as of the Effective Date
in the Region.

1.27 "Passive
Sales" or "Passive Selling" means[***].

1.28 "PCR"
means polymerase chain reaction technology.

1.29 "Plasma
Fractionation" means the commercial use of products that detect nucleic acid sequence(s) for the screening of plasma or blood components intended for use in
blood products (e.g., without limitation, immunoglobulins).

1.30 "Product(s)"
means reagents, compositions or kits suitable for use in the Field.

1.31 "Region"
shall mean, with respect to any Calendar Quarter, all member states whose accession to the European Union has become effective on or before the first day of
each such Calendar Quarter.

1.32 "Registration"
means a filing with respect to the commercial sale of the CHIRON Licensed Products made with any governmental or regulatory body or other body having
authority over the commercial sale of the CHIRON Licensed Products, made[***]of this Agreement in any country located within,
or covering all of the countries within, the Region including, without limitation, applications for registration under the CE mark.

1.33 "Release
Screening" means, as to Plasma Fractionation only, the quality control testing of plasma samples that have previously been screened for the presence of HIV
using (a) a CHIRON Licensed Product for which at least the applicable Earned Royalty Amount has been paid, (b) any other Product for the detection of HIV licensed by CHIRON for sale or
use in Plasma Fractionation or (c) a Product sold or used by CHIRON for the detection of HIV.

1.34 "ROCHE
Future HIV Sequence Patent Rights" means any and all Valid Claims Directed to HIV of United States and foreign patents and patent applications: (a) which
are based on inventions conceived or rights acquired[***]; (b) are not ROCHE Optioned Patents (as defined below);
(c) which claim HIV nucleic acid sequence(s) or a method to use (other than in the manufacture of peptides) or detect such sequences specifically; (d) which are owned by, licensed to or
otherwise controlled by ROCHE or its Affiliate, with rights to license or sublicense; and (e) with respect to which ROCHE has the right to grant the option provided for in Section 2.5 of
this Agreement. For purposes of this Agreement, an invention will be deemed to have been conceived if there is a patent, patent application, written invention disclosure statement or other tangible
document (whether or not witnessed) describing such invention.

1.35 "ROCHE
Non-HCV/HIV Analyte Patent Rights" means any and all Valid Claims of U.S. and foreign patents and patent applications: (a) which claim any
nucleic acid sequence(s) or transmissible disease-causing agent(s), other than HCV or HIV; (b) which is a blood borne, infectious disease or virus to the extent such Valid Claims cover the
detection of any nucleic acid sequence(s) or transmissible disease-causing agent(s) of such infectious disease or virus; (c) which are owned by, licensed to or otherwise controlled by ROCHE or
its Affiliates, with right to license or sublicense; and (d) with respect to which ROCHE has the right to grant the option provided for in Section 2.5 of this Agreement.

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1.36 "ROCHE
Optioned Patents" means: (a) the patents and applications identified in Exhibit C and any continuation,
continuation-in-part and divisional applications therefrom; (b) any reissued or reexamined patents obtained from such patents and applications; (c) all foreign
counterparts of such patents and applications; and (d) all future patents and applications which are based on inventions conceived by ROCHE or its Affiliates [***], to the extent the items
described in clauses (a) through (d) of this Section 1.36 contain a Valid
Claim Directed to HIV which covers the manufacture, use, sale, offer for sale or importation of a product in the Field or in Transplantation.

1.37 "ROCHE
Optioned Product" means a Product which is manufactured, used, offered for sale, imported or sold under circumstances which would, in the absence of the license
for which an option is granted under Section 2.3, constitute an infringement of a Valid Claim of the ROCHE Optioned Patents.

1.38 "ROCHE
Optioned Rights" means the ROCHE Future HIV Sequence Patent Rights and the ROCHE Non-HCV/HIV Analyte Patent Rights.

1.39 "Term"
has the meaning set forth in Section 7.1.

1.40 "Transplantation"
means the commercial use of products that detect nucleic acid sequences for the screening of any biological materials intended for transfusion or
transplantation, in each case from any donor, including autologous donors, other than the transfusion or transplantation of blood or its derivatives, components or replacements.

1.41 "Units"
means the number of individual donations of blood, plasma or other blood components that are tested for Blood Screening by End Users through the use of a CHIRON
Licensed Product. In the event that ROCHE or its Affiliates perform assays for commercial purposes utilizing CHIRON Licensed Product, Units shall include the number of individual donations of blood,
plasma or other blood components that are so tested by ROCHE or its Affiliates. Notwithstanding the foregoing, Units shall not include those CHIRON Licensed Products used by or for End Users at no
charge by ROCHE for (A) reasonable quantities of quality control or evaluation testing or (B) replacement of defective goods. In the case of pooled blood samples tested through the use
of a CHIRON Licensed Product, "individual donations of blood" refers to each individual donation of blood, plasma or other blood components that is represented in the tested pool, regardless of the
number of times such donation is tested.

1.42 "Valid
Claim" means a claim in any issued, active, unexpired patent which has not been withdrawn, cancelled, lapsed or disclaimed, or held unpatentable, invalid or
permanently unenforceable by a non-appealed or nonappealable final decision by a court or other appropriate body of competent jurisdiction. The scope of a Valid Claim shall be limited to
its terms as defined by any such court or decision-making body of competent jurisdiction in a nonappealable or non-appealed final decision.

ARTICLE 2  LICENSE AND OPTION GRANTS

2.1CHIRON Grants.Subject to the terms and conditions of this Agreement, CHIRON hereby grants to ROCHE and its
Affiliates, so long as they remain Affiliates of ROCHE, a nonexclusive license, without the right to sublicense except to have made or to conduct research, under the CHIRON Licensed Patents to
research, develop, make, have made, import, use, offer for sale and sell CHIRON Licensed Products within the Region for use in the Field and, to the extent permitted in Section 12, for use
outside of the Field. CHIRON covenants not to sue any End User of a CHIRON Licensed Product (with respect to which ROCHE has performed all of its material obligations under this Agreement) to the
extent of activities in the Field, outside of the Field (to the extent provided in Section 12) or as otherwise permitted under this Agreement. Conversely no immunity from suit shall apply to
End User activities inIn VitroDiagnostics, or otherwise outside of the Field, except as

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otherwise
provided in this Agreement or as provided in the HIV Diagnostics Agreements. Subject to Paragraph 4 of Exhibit A, CHIRON retains the nonexclusive right to practice and to grant
licenses under the CHIRON Licensed Patents to make, have made, use, import, offer for sale and sell any Products in the Field and all rights outside of the Field.

2.2Exclusion from CHIRON License.ROCHE acknowledges that neither ROCHE nor its Affiliates are licensed under
this Agreement to perform research or to develop any product other than a CHIRON Licensed Product.

2.3ROCHE Optioned Patents.Subject to the terms and conditions of this Agreement, ROCHE hereby grants to CHIRON
and its Affiliates, so long as they remain Affiliates of CHIRON, an option to enter into a nonexclusive license, with no right to sublicense except to have made or to conduct research, under ROCHE
Optioned Patents to research, develop, make, have made, import, use, offer for sale and sell ROCHE Optioned Products within the Region for use in the Field and in Transplantation. [***]

2.4CHIRON Optioned Rights.CHIRON grants to ROCHE a nonexclusive option to obtain one or more nonexclusive
licenses, or sublicenses, as the case may be, with a right to sublicense to ROCHE Affiliates only, under the CHIRON Optioned Rights, to make, have made, use, import, offer for sale and sell CHIRON
Licensed Products and/or products within the Region in the Field and in Transplantation (including as to CHIRON Non-HCV/HIV Analyte Patent Rights products for the detection of other
transmissible disease-causing agents).[***]

2.5ROCHE Optioned Rights.ROCHE grants to CHIRON a nonexclusive option to obtain one or more nonexclusive
licenses, or sublicenses, as the case may be, with a right to sublicense to CHIRON Affiliates only, under the ROCHE Optioned Rights, to make, have made, use, import, offer for sale and sell products
within the Region in the Field and in Transplantation (including as to ROCHE Non-HCV/HIV Analyte Patent Rights products for the detection of other transmissible disease-causing agents). [***]

2.6Option Terms.As to any Valid Claim(s) included within CHIRON Optioned Rights or ROCHE Optioned Rights, the
options set forth in Sections 2.4 and 2.5 may be exercised at any time[***]during the life of such patent(s), by written
notice from the option grantee to the option grantor identifying the patent(s) under which the grantee wishes to obtain a license; [***].[***]The terms of
such license agreement will be
subject to the following:

(a)   [***];

(b)   [***];

(c)   [***];

(d)   The
licensee will be able to terminate the license agreement at any time by giving the licensor prior written notice;

(e)   The
licensee will not have any right of enforcement, and will not receive from the licensor any warranty of validity or noninfringement; provided, however, the licensor
shall disclose to the licensee prior to entering into such license, any knowledge it has of any pending or written threatened claim that is material to any challenge of validity or enforceability,
except to the extent that such disclosure is subject to an obligation of confidentiality, protective order or legal privilege; and

(f)    [***].

2.7Need for Option.CHIRON may, at any time hereunder, provide written notification to ROCHE that certain
products being sold or used by ROCHE within the Region are believed by CHIRON to be covered by one or more Valid Claims of a patent included within CHIRON Optioned Rights not licensed to ROCHE. In the
event ROCHE does not,[***]of receipt of such notification,

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exercise
the relevant option provided for under Section 2.4 to obtain a license under such CHIRON Optioned Right, then CHIRON and ROCHE shall promptly thereafter confer in good faith to discuss
their respective positions concerning whether such products being sold or used by ROCHE within the Region are covered by a Valid Claim of the patent in question. If within ninety (90) days
following the above-mentioned notification,[***].

2.8Option Exercise.[***].

2.9Effect on Option by Termination.Termination of this Agreement pursuant to Article 7 shall terminate
the provisions of Sections 2.3 to 2.9; provided, however, that if at the time of such termination or, if prior notification is required under Section 7.3, then if immediately prior to the
effective date of termination set forth in such notification: (a) a license agreement arising out of the options granted under Section 2.3, 2.4 or 2.5 is in effect, such license shall
survive such termination under Article 7 and shall remain in effect in accordance with its terms; or (b) a party has properly exercised an option pursuant to Section 2.3, 2.4 or
2.5 and is proceeding in good faith to negotiate a license agreement thereunder, the parties shall complete such negotiations in good faith.

2.10Third Party Patents.Each party shall use reasonable commercial efforts to acquire the right to grant the
options provided in Sections 2.4 and 2.5 when it acquires rights under patents of third parties.

ARTICLE 3  PAYMENTS, ROYALTIES

With respect to all Units, ROCHE shall make payments to CHIRON as set forth in Exhibit A. For the avoidance of doubt, payments are due CHIRON only with
respect to (a) CHIRON Licensed Products sold in a country within the Region where there is a Valid Claim of a CHIRON Licensed Patent and (b) CHIRON Licensed Products used by ROCHE or its
Affiliates to perform assays for commercial purposes or by an End User in a country within the Region where there is a Valid Claim of a CHIRON Licensed Patent.

ARTICLE 4  RECORDS AND REPORTS

4.1Units Data.ROCHE shall use commercially reasonable efforts to collect Units data for each Calendar Quarter
from End Users in such detail and accuracy so as to enable a determination of the amounts payable by ROCHE to CHIRON hereunder. In the event an End User fails to timely report its Units data for a
Calendar Quarter to ROCHE, ROCHE shall include in the report for such Calendar Quarter required under Section 4.2 a reasonable estimate of the number of such Units, subject to a "true up"
correction in the subsequent Calendar Quarter.[***].

4.2Earned Royalty Report.ROCHE shall, within ninety (90) days after the last day of each Calendar
Quarter commencing on or[***], deliver to CHIRON a true and accurate report for the prior Calendar Quarter, substantially in
the form attached as Exhibit E to this Agreement, which shall state the amount of monies due hereunder, if any, as Earned Royalties, and shall include all information reasonably necessary to
calculate such amount, including, but not limited to, the following information, presented for the Region by Product and Field Category (as defined in Paragraph 1 of Exhibit A):



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Upon
written request by CHIRON, ROCHE will annotate and redeliver to CHIRON any Earned Royalty Report four (4) or more Calendar Quarters old to include Units and Earned Royalty Amounts on a
country-by-country basis with respect to each country located in the Region.

4.3Payment Dates.Not later than seventy-five (75) days after the last day of each Calendar
Quarter commencing on or after the[***], ROCHE shall pay to CHIRON a good faith estimate of the Earned Royalty for such
Calendar Quarter due under this Agreement. Such good faith estimate shall be based on the most recent Units data available to ROCHE, together with such reasonable growth and seasonality assumptions
utilized by ROCHE for internal planning purposes. If no Earned Royalties are due, ROCHE shall so report, stating the reasons why no such royalty is due. Not later than the date each Earned Royalty
Report required under Section 4.2 is due, ROCHE shall "true-up" its estimated Earned Royalty payment based on the number of Units set forth in the Earned Royalty Report for such
Calendar Quarter and, if it is determined that the estimate of Earned Royalties paid was less than the amount actually due for such Calendar Quarter, pay the underpaid amount, plus interest at the
rate described in Section 4.9. If it is determined that the estimate of Earned Royalties paid was more than the amount actually due for such Calendar Quarter, such overpaid amount shall be
credited against Earned Royalties payable on Units in the subsequent Calendar Quarter, plus interest at the rate described in Section 4.9.

4.4Payment Procedures.ROCHE shall pay royalties and all other payments due hereunder to CHIRON in immediately
available funds on the due date by wire transfer to:



or
at such place and in such other manner as CHIRON may designate in a notice signed by CHIRON's Treasurer or Controller to ROCHE.

4.5Taxes on Royalties.ROCHE shall deduct from amounts payable hereunder all taxes assessed or imposed against,
or required to be withheld from, royalty payments due and shall pay such amount to the appropriate fiscal or tax authorities on behalf of CHIRON. ROCHE shall forward promptly to CHIRON all tax
receipts received by ROCHE evidencing payment of such taxes.

4.6Audit Rights.



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4.7Confidentiality of Audit.CHIRON agrees that all audited information shall be confidential to ROCHE and its
Affiliates, and that any person or entity conducting an audit on behalf of CHIRON pursuant to Section 4.6 shall be required to protect the confidentiality of such information.

4.8Payment in United States Currency.All payments shall be made in United States Dollars and shall be made on
the dates set forth herein.

4.9Late Payment Fee.Any payment, including, without limitation, royalty payments, made by ROCHE hereunder
after the date such payment is due, as set forth in this Article 4 hereof, shall bear interest at the lesser of:
(a)[***]as published in the Wall Street Journal as of the date such payment was due, or (b) the maximum rate
permitted by applicable law.

ARTICLE 5  OTHER ACTIONS

5.1Patent Validity; Enforceability.ROCHE represents and warrants that, on or before the Effective Date and
consistent with the Settlement Agreement, it has discontinued any opposition, challenge, compulsory license application or the like with respect to the CHIRON Licensed Patents within the Region.
CHIRON represents and warrants that, on or before the Effective Date and consistent with the Settlement Agreement, it has discontinued any opposition, challenge, compulsory license application or the
like with respect to the ROCHE Optioned Patents within the Region.

5.2Compulsory Licensing.ROCHE covenants and agrees on behalf of itself and its Affiliates to not support any
third party in seeking compulsory licensing of the CHIRON Licensed Patents in the Region. As used in this Section, "support" shall have the same meanings as in Section 7.2(b).

5.3Registrations.Notwithstanding the provisions of Section 12.1 of this Agreement or
Section 12.1 of the HIV Diagnostics Agreements, ROCHE or any of its Affiliates may elect, at any time during the Term, in its sole discretion and at its sole cost and expense, to seek a
Registration, or to provide assistance to a third party in such third party's seeking a Registration, of a CHIRON Licensed Product [***]. If ROCHE or an Affiliate of ROCHE files a Registration, or
provides substantial assistance to a third party for such
third party's Registration,[***]then ROCHE or the applicable ROCHE Affiliate will promptly inform CHIRON in writing of the
existence and subject

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matter
of such Registration. CHIRON acknowledges and agrees that ROCHE's or any ROCHE Affiliate's election to seek (or assist a third party in seeking) any such Registration outside of the Field
(absent other labeling or promoting activities by ROCHE or such ROCHE Affiliate which would independently fall outside of the definition of Passive Selling) will constitute Passive Selling for
purposes of this Agreement.[***]

ARTICLE 6  REPRESENTATIONS AND WARRANTIES

6.1Corporate Authority.Each party represents and warrants to the other party that it has the necessary
corporate authority to enter into this Agreement.

6.2Right to Grant.Each party represents and warrants that they have the right to grant the licenses and
options granted in Article 2 hereof and that they are the sole owner of their respective Licensed/Optioned Patents, subject to licenses existing as of the Effective Date. CHIRON represents and
warrants to ROCHE that, to the best of its knowledge, neither CHIRON nor any of its Affiliates have transferred to[***]or any
if its Affiliates (a) before December 1, 1998, title to any patent or patent application Directed to HIV in the Field existing on that date; or (b) on or after that date, title to
any patent, patent application or invention Directed to HIV in the Field.

6.3Current Licenses.CHIRON represents and warrants that: (a) as of the Effective Date the entities set
forth in Exhibit F are the only parties to which it has granted any licensed rights or other grants or
immunities to one or more of the CHIRON Licensed Patents in the Field; and (b) Exhibit F contains a complete and accurate description of the effective scope, field and territory of such
grant as of the Effective Date. CHIRON also represents and warrants that[***]except as disclosed in Exhibit F.

6.4Complete Patent List.CHIRON represents and warrants to ROCHE that, to the best of its knowledge and belief,
Exhibit B contains a complete list, as of the Effective Date, of all patents and patent applications owned by, licensed to (with a right to sublicense), or otherwise controlled by CHIRON or its
Affiliates containing claims Directed to HIV in the Field in any country located in the Region. To the extent that any other patent or patent application owned by, licensed to (with a right to
sublicense) or otherwise controlled by CHIRON or its Affiliates and filed on or before the Effective Date contains a claim Directed to HIV in the Field in any country located in the Region, such
patent or patent application shall be automatically added to the CHIRON Licensed Patents. Upon ROCHE's written request, not more frequently than annually, CHIRON shall provide ROCHE with an updated
Exhibit B and a report of the prosecution status of applications within CHIRON Licensed Patents. ROCHE represents and warrants to CHIRON that, to the best of its knowledge and belief,
Exhibit C contains a complete list, as of the Effective Date, of all patents and patent applications owned by, licensed to (with a right to sublicense), or otherwise controlled by ROCHE or its
Affiliates containing claims Directed to HIV in the Field in any country located in the Region. To the extent that any other patent or patent application owned by, licensed to (with a right to
sublicense) or otherwise controlled by ROCHE or its Affiliates and filed on or before the Effective Date contains a claim Directed to HIV in the Field in any country located in the Region, such patent
or patent application shall be automatically added to the ROCHE Optioned Patents. Upon CHIRON's written request, not more frequently than annually, ROCHE shall provide CHIRON with an updated
Exhibit C and a report of the prosecution status of applications within ROCHE Optioned Patents.

6.5Exclusions.Nothing contained in this Agreement shall be construed as:



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6.6Further ROCHE Assurance.ROCHE acknowledges that the inclusion of ROCHE Affiliates within the license and
option grants pursuant to Sections 2.1 and 2.4 is intended to enable ROCHE to utilize the manufacturing and sales capabilities of its Affiliates in connection with the manufacture and sale of CHIRON
Licensed Products in a manner substantially similar to the involvement of such Affiliates in the manufacture and sale of ROCHE's products generally. ROCHE shall not, directly or indirectly, take any
action having or intended to have the effect of sublicensing ROCHE's rights under any of the CHIRON Licensed Patents, other than to abona fideAffiliate, including, without limitation, by creating Affiliates specifically in connection with CHIRON Licensed Products, or through other third party arrangements such as joint ventures,
collaborations, or distribution arrangements with distributors. ROCHE and its Affiliates are licensed hereunder to sell and distribute CHIRON Licensed Products only under the label, name and trademark
rights owned by, licensed to or otherwise controlled by ROCHE or its Affiliates, and only through the sales force of ROCHE or its Affiliates, or through Authorized Distributors or Cross Sellers
(subject to Section 12). ROCHE and its Affiliates are not licensed to perform OEM manufacturing of CHIRON Licensed Products for a third party other than an Authorized Distributor or a Cross
Seller (subject to Section 12); to supply CHIRON Licensed Products for resale to any third party other than an Authorized Distributor or a Cross Seller (subject to Section 12); to permit
any Authorized Distributor or other third party to sell any CHIRON Licensed Products under another third party label, name or trademark or to permit any Authorized Distributor or other third party to
sell any CHIRON Licensed Products under the Authorized Distributor's or any third party's own label, name or trademark for use on an instrument bearing the label name or trademark of a party other
than ROCHE or its Affiliates; provided, however, that nothing in this Section 6.6 shall be construed to limit the rights of ROCHE or its Affiliates to engage in activities with such third
parties, to the extent such third parties have obtained rights under the CHIRON Licensed Patents permitting such activities.

6.7Limitation of Warranty.EXCEPT AS SPECIFICALLY SET FORTH HEREIN, NO PARTY MAKES ANY REPRESENTATION OR
WARRANTY, EITHER EXPRESS OR IMPLIED, ARISING BY LAW OR OTHERWISE, INCLUDING, BUT NOT LIMITED TO, IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE.

ARTICLE 7  TERM AND TERMINATION

7.1Term.



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7.2Voluntary Termination.ROCHE may voluntarily terminate all, but not less than all, licenses granted to ROCHE
and its Affiliates under this Agreement and the Original License Agreement on a country-by-country basis within the Region, on not less than six (6) months prior written
notice to CHIRON.

7.3Termination by CHIRON.CHIRON may terminate this Agreement and the Original License Agreement only upon any
of the following grounds:



7.4Enforcement After Termination.Upon valid termination of this Agreement under Section 7.2 or 7.3,
ROCHE and its Affiliates shall have no further rights under CHIRON Licensed Patents and CHIRON shall not be limited to its remedies under this Agreement, to the extent of such termination.

7.5Accrued Rights.Termination of this Agreement for whatever reason shall not affect any rights which have
accrued prior to termination, including without limitation royalty obligations occurring during the Term, calculated in accordance with Article 3 and Exhibit A.

7.6ROCHE Challenge to Section 7.3(a) Termination.In the event ROCHE provides written notification to
CHIRON prior to expiration of the thirty (30) day notice/cure period referenced in Section 7.3(a) that ROCHE disputes whether the grounds for termination under Section 7.3(a) are
present, such dispute shall be submitted to ADR pursuant to Article 10. The thirty (30) day notice/cure period shall be suspended during the pendancy of such ADR, provided that during
the pendancy of the

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ADR,
ROCHE shall continue to make any disputed payments to CHIRON, on the condition that CHIRON shall repay ROCHE the amounts of such disputed payments if ROCHE prevails in the ADR, plus interest at
the rate described in Section 4.9. Notwithstanding anything in this Section 7.6 to the contrary, ROCHE may submit a dispute concerning a method by which amounts payable by ROCHE and its
Affiliates to CHIRON hereunder are calculated only one time, and any resolution from the ADR shall bind the parties as to such calculation method thereafter.

7.7ROCHE Challenge to Section 7.3(b) Termination.In the event that ROCHE, within thirty
(30) days of receiving notice of termination by CHIRON for the grounds set forth in Section 7.3(b) above, provides written notice to CHIRON that ROCHE disputes whether such grounds are
present, such dispute shall be submitted to ADR pursuant to Article 10 and termination of this Agreement shall be suspended during the pendancy of the ADR, provided that ROCHE suspends its
action, suit or proceeding (other than in an ADR proceeding between the parties as permitted by Section 7.3 (b) and Article 10) [***], and continues to perform all of its material
obligations hereunder.

7.8Audit Results Not Grounds for Termination.CHIRON's request for an audit under Section 4.6 shall not
be treated as a notice of breach under Section 7.3(a). In the event such audit determines there has been an underpayment by ROCHE, such underpayment shall not constitute grounds for termination
by CHIRON under Section 7.3(a) unless: (a) ROCHE has failed to rectify such underpayment in accordance with Section 4.6; (b) ROCHE has failed to rectify such underpayment
after notification and opportunity to cure under Section 7.3(a); and (c) any ADR requested by ROCHE, pursuant to Section 7.6, and directed to any dispute concerning such
underpayment, results in a determination favorable to CHIRON and ROCHE has failed to rectify such underpayment. Notwithstanding the foregoing, ROCHE shall continue to make the disputed payments to
CHIRON, on the condition that CHIRON shall repay ROCHE the amounts of such disputed payments with respect to which ROCHE prevails in the ADR, plus interest at the rate described in Section 4.9.

7.9Survival.The following provisions of this Agreement shall survive termination or expiration of this
Agreement, in accordance with their respective terms: Article 1; Sections 4.6, 4.7, 4.8, 4.9, 6.7, 7.4, 7.5 and 7.9; Articles 8, 9, and 10; Sections 11.9 through 11.14; Section 12.2(b);
and Section 14.1.

ARTICLE 8  CONFIDENTIALITY

8.1Obligation.From time to time during the Term, CHIRON and ROCHE may provide to each other information
concerning patents, patent applications, license agreements and other confidential or proprietary information related to this Agreement (the "Information"). Notwithstanding anything in this Agreement
to the contrary, following the execution of this Agreement, Earned Royalty Amounts payable under this Agreement shall be deemed "Information" as to which both CHIRON and ROCHE shall be deemed to be
the party receiving the Information (the "Receiving Party"). Each Receiving Party shall during the Term and for a period of three (3) years after termination hereof: (a) maintain the
Information in confidence; (b) not disclose the Information to any third party, other than employees, agents or consultants of the Receiving Party, its Affiliates or permitted sublicensees who
have a need to know the Information and who are bound by confidentiality obligations to the Receiving Party no less restrictive than those contained herein; and (c) not use the Information for
any purpose not directly related to performance hereunder or otherwise authorized under this Agreement.

8.2Exclusions.The obligations of this Article 8 shall not apply to any Information which: (a) is
or which becomes generally known to the public by publication or by means other than a breach of a duty by the Receiving Party; (b) is otherwise known by the Receiving Party at the time of
disclosure by the other party; (c) otherwise becomes available to the Receiving Party from a third party not in breach of confidentiality obligations to the other party; or (d) is
developed by or for the Receiving Party

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independent
of any disclosure from the other party. The Receiving Party also shall be permitted to make disclosures of Information which are reasonably necessary in connection with a possible grant of
a permitted sublicense by the Receiving Party or in due diligence related to a possible acquisition, merger, consolidation, substantial asset transfer or similar transaction of the Receiving Party,
provided that the recipient is bound to the Receiving Party by confidentiality obligations with respect to the Information no less restrictive than those contained herein. Nothing herein shall prevent
the Receiving Party from making such disclosures of Information as are reasonably required by law, regulation (including 37 C.F.R. § 1.56), or order of any court or governmental agency;
provided that the Receiving Party has provided reasonable advance notice to allow the disclosing party the opportunity to seek a protective order or otherwise contest, prevent or limit such
disclosure.

8.3Return of Information.Upon termination of this Agreement for any reason, the Receiving Party shall return,
or at the option of the disclosing party, certify destruction of, all Information and copies thereof; provided that the Receiving Party may retain one copy thereof in its law department files solely
for evidentiary and regulatory purposes.

8.4Disclosure of Agreements and Terms.Each of the parties may issue a press release disclosing the existence
of this Agreement. Subject to mutual agreement as to form and substance, the parties may make selected disclosure of the material financial terms in such press releases. Each party may disclose any of
the terms of this Agreement to any Affiliate; provided that the recipient of such disclosure is obligated to confidentiality terms no less restrictive than those contained in this Article 8.
Each party may disclose any information contained in or regarding this Agreement to the extent required in its respective reasonable judgment by applicable law, regulation or order of any court or
governmental agency. Further, each party may determine in its respective discretion to file this Agreement under the Securities and Exchange Act of 1934 or otherwise with any United States or foreign
governmental agency, even if that filing may result in this Agreement becoming available to the public generally. The filing party shall seek confidential treatment for at least the essential
financial terms hereof in connection with any such filing, subject to applicable law and regulation, and shall notify the other party in advance of any such filing and consider such suggestions as the
other party may make as to the terms herein as to which the filing party should seek confidential treatment.

ARTICLE 9  INDEMNITY

9.1ROCHE Indemnity.ROCHE shall indemnify, defend and hold harmless CHIRON and its Affiliates and their
officers, directors, shareholders, employees, representatives and agents, against any claim, demand, loss, damage or injury, including reasonable attorneys' fees, asserted by a third party, arising
from, relating to, or otherwise in respect of, (a) the manufacture, use or sale of CHIRON Licensed Products within the Region, or (b) any breach by ROCHE or its Affiliates of any
representation, warranty or covenant under this Agreement; provided, however, that such indemnity shall not extend to damages arising directly from any breach or willful or negligent act of CHIRON or
its Affiliates.

9.2CHIRON Indemnity.CHIRON shall indemnify, defend and hold harmless ROCHE and its Affiliates and their
officers, directors, shareholders, employees, representatives and agents, against any claim, demand, loss, damage or injury, including reasonable attorneys' fees, asserted by a third party, arising
from, relating to, or otherwise in respect of, (a) the manufacture, use or sale of ROCHE Optioned Products within the Region, or (b) any breach by CHIRON or its Affiliates of any
representation, warranty or covenant under this Agreement; provided, however, that such indemnity shall not extend to damages arising directly from any breach or willful or negligent act of ROCHE or
its Affiliates.

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9.3Indemnification Procedures.In the event either party claims indemnification pursuant to this
Article 9, the indemnified party shall promptly notify the indemnifying party in writing upon becoming aware of any claim to which such indemnification may apply. Delay in providing such notice
shall constitute a waiver of the indemnifying party's indemnity obligations hereunder only if the indemnifying party's ability to defend such claim is materially impaired thereby. The indemnifying
party shall have the right to assume and solely control the defense of the claim at its own expense. If the right to assume and solely control the defense is exercised, the indemnified party shall
have the right to participate in, but not to control, such defense at its own expense, and the indemnifying party's indemnity obligations shall be deemed not to include attorneys' fees and litigation
expenses incurred by the indemnified party after the assumption of the defense by the indemnifying party. If the indemnifying party does not assume the defense of the claim, the indemnified party may
defend the claim at the indemnifying party's expense. The indemnified party shall not settle or compromise the claim without the prior written consent of the indemnifying party, and the indemnifying
party shall not settle or compromise the claim in any manner which would have an adverse effect on the indemnified party without the consent of the indemnified party, which consent, in each case,
shall not be unreasonably withheld. The indemnified party shall reasonably cooperate with the indemnifying party and shall make available to the indemnifying party all pertinent information under the
control of the indemnified party, all at the expense of the indemnifying party.

9.4Sunset.The provisions of Sections 9.1 and 9.2 shall continue in effect on a
claim-by-claim basis, after the termination of this Agreement, only until the expiration of the last to expire statute of limitations applicable to such claim.

9.5Limitation of Liability.Neither party shall be liable to the other for any consequential, special, indirect
or exemplary damages or for the loss of profits arising from the performance or nonperformance of this Agreement or any acts or omissions associated herewith.

ARTICLE 10  ALTERNATIVE DISPUTE RESOLUTION

The parties recognize thatbona-fidedisputes may from time to time arise which relate to any aspect
of this Agreement, including, without limitation, any of the parties' rights and/or obligations hereunder, and including, without limitation, disputes relating to the interpretation, form validity,
performance and/or termination of this Agreement or relating to infringement, scope, claims construction, or (without limiting the effect of Section 7.3(b)) validity or enforceability of the
CHIRON Licensed Patents. In the event of the occurrence of any dispute, a party may, by notice to the other party, have such dispute referred to their respective employees designated below or their
successors, for attempted resolution by good faith negotiations within ninety (90) days after such notice is received. Said designated officers are as follows:

For ROCHE: President
Roche Molecular Systems, Inc.For CHIRON: President
Blood Testing


In
the event the designated officers, after such good faith negotiations, are not able to resolve such dispute within such ninety (90) day period, or any agreed extension thereof,
a party may invoke the provisions for binding ADR as set forth in Paragraph 9 of the Settlement Agreement. Neither party shall seek recourse against the other hereunder in any court or other
forum, except as permitted by Paragraph 9 of the Settlement Agreement or as may be necessary to enforce a determination made in ADR pursuant to this Article 10 and Paragraph 9 of
the Settlement Agreement.

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ARTICLE 11  MISCELLANEOUS

11.1Assignment.



11.2Force Majeure.A party hereto shall not be liable for, nor shall this Agreement be terminable or cancelable
by reason of, any delay or default in any such party's performance hereunder, to the extent that such default or delay is caused by events beyond such party's reasonable control including, but not
limited to: acts of God; regulation, law or action of any government or agency thereof; war or insurrection; civil commotion; labor disturbances; epidemic; or failure of suppliers, public utilities or
common carriers. Each party shall give prompt notice to the other party of such cause, and shall take whatever reasonable steps are necessary to relieve the effect of such cause as rapidly as
possible.

11.3Severability.In the event that any one or more of the provisions of this Agreement should for any reason
be held by any court or authority having jurisdiction over this Agreement or over the parties hereto to be invalid, illegal or unenforceable, such provision or provisions shall be reformed to
approximate as nearly as possible the intent of the parties, in such jurisdiction; elsewhere, this Agreement shall not be affected.

11.4Entire Agreement; Termination of Original License Agreement.This Agreement together with the Exhibits,
Attachments and Schedules and[***], constitute the entire agreement among the parties relating to the subject matter of this
Agreement. Upon execution and delivery of this Agreement, the parties acknowledge and agree that this Agreement shall supercede all prior written and oral agreements with respect to the subject matter
hereof, including specifically the
Original License Agreement, which is hereby terminated and superceded by this Agreement solely with respect to its application to the Region, as more fully described in Section 7.1(a) above.
There are no other understandings, representations or warranties of any kind.

11.5Amendment.This Agreement shall not be altered, extended or modified except by written agreement of the
parties.

11.6Waiver.Failure by a party hereunder to enforce any right under this Agreement shall not be construed as
waiver of such right or any other rights under this Agreement; nor shall a waiver by a party hereunder in one or more instances be construed as constituting a continuing waiver or as a waiver in other
instances.

11.7Costs.Each of the parties hereto shall be responsible for its respective legal and other costs incurred in
relation to the preparation of this Agreement.

11.8Counterparts.This Agreement may be executed in two (2) or more counterparts, each of which shall be
deemed to be an original, but all of which, taken together, shall constitute one and the

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same
instrument. Facsimile copies of signatures for a party shall be deemed to be originals for purposes of execution of the Agreement.

11.9Notices.



ROCHE:

F. Hoffmann-La Roche Ltd.
Grenzacherstrasse 124
Basel
Bale 4002
Switzerland
Attn: Head of Diagnostics DivisionCopy to:

General Counsel
Roche Molecular Systems, Inc.
1145 Atlantic Avenue
Alameda, CA 94501CHIRON:

Chiron Corporation
4560 Horton Street
Emeryville, California 94608
Attn.: President, Blood TestingCopy to:

General Counsel
Chiron Corporation
4560 Horton Street
Emeryville, CA 94608




11.10Governing Law.All matters affecting the interpretation, form, validity, performance and termination of
this Agreement shall be decided and interpreted under the laws of the State of New York, excluding any choice of law rules which may direct application of the laws of any other jurisdiction.

11.11Relationship of the Parties.The relationship of the parties under this Agreement is that of independent
contractors. Nothing contained in this Agreement is intended or is to be construed so as to constitute the parties as partners, joint venturers or agents of the other. Neither party or its Affiliates
has any express or implied right or authority under this Agreement to assume or create any obligations or make any representations or warranties on behalf of or in the name of the other party or its
Affiliates.

11.12Headings.The headings of the Articles and Sections in this Agreement have been inserted for convenience
only and do not constitute part of this Agreement.

11.13No Trademark Rights.No right, express or implied, is granted by this Agreement to either party to use in
any manner the name, trade name or trademark of the other party in connection with the performance of this Agreement.

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11.14No Implied Licenses.No license, express or implied, is granted by this Agreement to either party, other
than the licenses or options granted under Sections 2.1, 2.3, 2.4 and 2.5.

ARTICLE 12  FIELD RESTRICTIONS AND OTHER COVENANTS

12.1ROCHE Covenant Regarding In VitroDiagnostics.

(a)   ROCHE
and its Affiliates shall not label or promote any CHIRON Licensed Product labeled or promoted for use in the Field in any respect for use outside the Field
(namely,In VitroDiagnostics) within the Region; and ROCHE shall use commercially reasonable efforts to prevent its Authorized Distributors from
labeling or promoting any CHIRON Licensed Products labeled or promoted for use in the Field in any respect for use outside the Field (namely,In VitroDiagnostics) within the Region.

(b)   Further,
ROCHE and its Affiliates and Authorized Distributors shall include on or with each CHIRON Licensed Product labeled or promoted for use in the Field within the
Region a statement to the effect that the CHIRON Licensed Product is not intended for use inIn VitroDiagnostics, using language to be determined by
ROCHE and approved in advance in writing by CHIRON, which approval shall not be unreasonably withheld. The location of such notice shall be the product insert of such CHIRON Licensed Products or such
other reasonably prominent location to be determined by ROCHE.

(c)   In
the event that ROCHE or CHIRON becomes aware of any material use inIn VitroDiagnostics of CHIRON Licensed Products
labeled or promoted for use in the Field within the Region, such party will promptly notify the other in writing of the relevant facts and, if so requested by CHIRON, ROCHE will meet and confer with
CHIRON in good faith to determine what steps either or both should take to abate such infringing use.

(d)   Nothing
in this Section 12.1 shall prohibit ROCHE from offering for sale or selling to End Users Products configured for use primarily in In VitroDiagnostics to satisfy thebona
fiderequirements of such End Users for use in In VitroDiagnostics and any Blood Screening use by such End Users of any such Products configured for use primarily inIn
VitroDiagnostics shall not be deemed a breach of this Section 12.1.

(e)   Nothing
in this Section 12.1 shall apply to any product or activity of ROCHE or its Affiliates to the extent that such product or activity is a necessary or
customary activity in connection with a Registration pursuant to Section 5.3.

12.2Passive Sales.

(a)   Notwithstanding
anything to the contrary in this Agreement and specifically the foregoing provisions of Section 12.1, nothing in this Agreement is intended to
prohibit Passive Sales of the CHIRON Licensed Product by ROCHE, its Affiliates or its Authorized Distributors or Cross Sellers (subject to Section 12) [***]within the Region. Passive Sales will be
subject to the royalty provisions set forth in Article 3 and
Exhibit A without application of any adjustment to Earned Royalties for Home Brew Screening pursuant to Paragraph (2) of Exhibit A.

(b)   Without
limiting the labeling and promoting obligations under Section 12.1, CHIRON shall not sue ROCHE, its Affiliates, its Authorized Distributors or its End
User customers (including, but not limited to, Cross Sellers) for any Passive Sale, or for the use byIn VitroDiagnostics End Users of a CHIRON
Licensed Product outside of the Field within the Region, whether arising during the Term, or during the term of the Original License Agreement prior to the Effective Date (it being understood that
nothing herein constitutes an admission by ROCHE or any of its Affiliates with respect to any such actual or alleged sales or use under the Original License Agreement).

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12.3Cross Sales.

(a)   Notwithstanding
anything to the contrary in this Agreement and subject to the provisions of this Section 12.3, nothing in this Agreement is intended to prohibit
an End User from selling CHIRON Licensed Product purchased from ROCHE, its Affiliates or an Authorized Distributor to another person or entity [***]within the Region ("Cross Sales").

(b)   Notwithstanding
the provisions of Section 12.1 of this Agreement or anything in this Agreement to the contrary, if at any time during the Term CHIRON forms a
reasonable belief that significant Cross Sales are occurring within the Region, it will promptly inform ROCHE in writing of the existence and basis of such belief. [***].

12.4Patent Marking.ROCHE and its Affiliates shall include a patent notice on each CHIRON Licensed Product to
identify the CHIRON Licensed Patents which such CHIRON Licensed Product, but for the licenses granted herein, would infringe one or more Valid Claims (or for which royalties are being paid); provided,
however, identification of CHIRON Licensed Patents on a CHIRON Licensed Product shall in no way be deemed to be an admission by ROCHE or its Affiliates, or raise a presumption, that such CHIRON
Licensed Product is in fact covered by such CHIRON Licensed Patent.

12.5 The
understanding and intent of the parties is that the amendments made by this Agreement reflect the unique circumstances applicable to ROCHE arising from the fact
that ROCHE is a licensee under both this Agreement and the HIV Diagnostics Agreements, and that, taking such unique circumstances into account, this Agreement imposes new burdens on ROCHE rather than
granting new benefits to ROCHE.[***].

ARTICLE 13  INFRINGEMENT BY THIRD PARTIES

13.1Notice of Infringement.Each party shall notify the other if it becomes aware of Infringing Third Party
Sales. CHIRON shall have the exclusive right to take action against any infringement of any of the CHIRON Licensed Patents, in its sole discretion, subject to this Article 13.

13.2Infringement Litigation.

(a)   In
the event that "substantial" Infringing Third Party Sales are occurring in a country within the Region in which ROCHE or its Affiliates or an Authorized Distributor
is selling a CHIRON Licensed Product (in each such, country, the "Impacted Product"), and ROCHE has notified CHIRON pursuant to Section 13.1 of the existence of such infringement in [***](an
"Infringement Notice"), then the provisions of this Section 13.2 shall apply. For purposes of this
Section 13.2, "Major Country" shall mean[***].

(b)   For
purposes of this Section 13.2, an Infringing Third Party Sale shall be considered substantial in a country if the infringing third party achieves market
share, in the case of Blood Screening of[***], and in the case of Plasma Fractionation of [***]of the Aggregated Products in such country[***].
For purposes of this Section 13.2, "Aggregated Products" means the number of Units of CHIRON Licensed Products of the applicable Field Category plus the number of Competitive Products sold (or
used, in the case of Plasma Fractionation) in a country, and "Competitive Products" means the number of Units of Products which are sold (or used, in the case of Plasma Fractionation) of the
applicable Field Category and which compete with a CHIRON Licensed Product sold or used by ROCHE or its Affiliates in a country.

(c)   If
the Infringement Notice identifies an Impacted Product in a Major Country and CHIRON fails to institute legal action in a Major Country or other country acceptable to
ROCHE[***]following receipt by CHIRON of the Infringement Notice and infringement is not otherwise abated,

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then
ROCHE shall be relieved of the obligation to pay the portion of Earned Royalties set forth in Section 13.2(d) with respect to the Impacted Product until such time as CHIRON institutes such
legal action as described in this Section 13.2(c); provided, however, that CHIRON need not initiate or continue any such legal action, if, after reasonably diligent effort (including reasonably
diligent effort by ROCHE if requested by CHIRON), CHIRON is unable to acquire admissible evidence sufficient to establish a prima facia case of infringement under the law of the applicable country;
and provided further, that CHIRON shall not be obligated to institute or maintain more than three such actions at any time with regard to Impacted Products in Plasma Fractionation.

(d)   If
CHIRON has not instituted such legal action at the end of such[***], to the extent required
under Section 13.2(c), and such infringement is not otherwise abated, the Earned Royalty with respect to an Impacted Product in Blood Screening shall be reduced by [***]from the amount otherwise
payable under Paragraph 1 of Exhibit A (excluding the effect of any reduction in
Earned Royalty Amounts triggered by operation of Paragraph 2 of Exhibit A) and with respect to an Impacted Product in Plasma Fractionation shall be reduced by [***]. If, at the end of[***]thereafter, CHIRON has
not instituted such legal action, to the extent so required, and infringement is not otherwise abated, Earned Royalties on such Impacted Product shall be reduced by [***]of the original Earned
Royalties, such that if legal action required under Section 13.2(c) has not commenced and
the infringement is not otherwise abated by, in the case of an Impacted Product in Blood Screening the end of the[***]following receipt by CHIRON of the Infringement Notice and in the case of an Impacted Product in Plasma Fractionation the end of the [***]following receipt by CHIRON of the Infringement Notice,
[***]shall be payable hereunder with respect to the Impacted Product.

(e)   The
obligations to pay Earned Royalties shall be reinstated on a prospective basis at such time as ROCHE receives written notice of the institution of legal action in
accordance with Section 13.2(c) or the infringement is otherwise abated, all subject to Section 13.2(f).

(f)    If
legal action required under Section 13.2(c) has not been instituted and the infringement is not otherwise abated in the case of an Impacted Product in Blood
Screening for more than[***]following receipt by CHIRON of the Infringement Notice and in the case of an Impacted Product in
Plasma Fractionation for more than[***]following receipt by CHIRON of the Infringement Notice, and if, as a result of the
infringement, sales of the Impacted Product[***]by ROCHE, its Affiliates or an Authorized Distributor have declined by [***]or more during the[***], then upon reinstatement
of Earned Royalties pursuant to Section 13.2(e), the parties shall meet and confer regarding possible adjustments to the Earned Royalties for the Impacted Product in view of such degradation of
the market. The parties will discuss possible rate reductions, as well as a plan for reinstating the original economic expectations of the parties. It is expected that any agreement for reduction of
Earned Royalties will be phased out over time, so as to return to the Earned Royalties set forth in Exhibit A. If the parties fail to reach agreement on any such adjustment, the matter shall be
submitted for resolution by ADR, except that in the event of ADR, each party shall submit to the neutral a proposal with respect to adjustments pursuant to this Section 13.2(f). The neutral
shall be empowered to choose one proposal or the other, but shall not be empowered to order any such adjustment other than as proposed by one of the parties.

13.3Cooperation.ROCHE and its Affiliates shall cooperate with CHIRON in connection with any legal action
referred to in this Article 13.

ARTICLE 14  OTHER EUROPEAN COMMUNITY PROVISIONS

14.1Competition Notification.If either party (the "Notifying Party") elects to file a notification with
respect to this Agreement (a "Notification") with the Competition Directorate of Commission of European Community (the "Commission") in accordance with regulations established by the

20

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Commission,
the Notifying Party shall provide a non-confidential version of the final draft to the other party for comment at least thirty (30) days before making the filing and
shall consider in good faith the modification thereto, if any, that the other party may propose. The other party shall execute all documents reasonably required by the Notifying Party and shall
otherwise reasonably cooperate in connection with the Notification. The Notifying Party shall bear all costs incurred by it relating to the Notification.

14.2Reformation.If, at any time during the Term, either party receives a request or other communication from
the Commission with respect to the Notification (a "Request"), such party shall promptly inform the other of the nature of the Request. In the event that the Commission indicates in a Statement of
Objection(s) that this Agreement will violate the provisions of Article 81 or 82 of the Treaty of Rome, then the parties shall amend this Agreement by making those minimal modifications
necessary to satisfy the concerns of the Commission as set forth in the Statement of Objection(s). Notwithstanding the foregoing, the parties agree that ROCHE shall retain substantially the same
license rights at substantially the same royalties as specified under this Agreement.

IN
WITNESS WHEREOF this Agreement has been executed by duly authorized officers of CHIRON and ROCHE as of the Effective Date.

|CHIRON CORPORATION           
|-----------------------------
|By:                          
|Title:                       
|Date:                        
|F. HOFFMANN-LA ROCHE LTD.    
|By:                          
|Title:                       
|Date:                        
|By:                          
|                             
|Title:                       
|Date:                        
|                             
|ROCHE MOLECULAR SYSTEMS, INC.
|By:                          
|Title:                       
|Date:                        

21

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Exhibit A  Compensation to Chiron Corporation

1.Earned Royalty.Subject to the adjustments referenced in this Exhibit A, royalties paid to CHIRON
under this Agreement in any Calendar Quarter (the "Earned Royalty") shall be calculated as follows:

The
Earned Royalty for each Calendar Quarter shall be the[***]:

Earned Royalty AmountsField Category[***]:

[***][***]:

[***]


(a)   Notwithstanding
the above,[***].

(b)   [***], the parties shall meet and reasonably consider adjustment to the Earned Royalty Amount
with respect to each CHIRON Licensed Product[***]. Any such adjustment should reflect both [***]. Accordingly, an increase in Earned Royalty Amounts may
be justified by an increase [***]. Generally, the parties intend that Earned Royalty Amounts should be not less than [***]. No adjustment shall be made to
any Earned Royalty Amount unless mutually agreed;[***].[***].

(c)   Earned
Royalties shall be payable quarterly, commencing with the Calendar Quarter ending[***],
within seventy-five (75) days following the end of each Calendar Quarter. Such payment shall be made in accordance with the payment and reporting obligations set forth in
Article 4 and is fully earned when paid and is non-refundable.

(d)   [***], the parties shall meet and reasonably consider adjustment to the allocation of
jurisdictions to the extent located within the Region. Generally, the parties intend that[***]. No adjustment shall be made to
the allocation of jurisdictions within the Region unless mutually agreed.

2.     Home
Brew Adjustment. With respect to sales of CHIRON Licensed Products in[***]for use in Blood
Screening, the[***]as set forth in this Paragraph 2, [***]:

|[***]
(in units) |  | Reduced
Earned Royalty Amount
|---------------- |  | -----------------------------
|[***]            |  | [***]                        
|[***]            |  | [***]                        

If
the parties are unable otherwise to agree within thirty (30) days of a request by either party,[***]. In the event
that Home Brew Screening achieve a market share[***]in Blood Screening [***], the parties shall meet and confer, at ROCHE's request, to consider
reasonably and in good faith the actions that CHIRON
might take to abate such Home Brew Screening.[***]. As used herein, "Home Brew Screening" shall mean the use in Blood Screening
of probe screening methods Directed to HIV not licensed by CHIRON and not utilizing any assay, kit, reagent or other component Directed to HIV made by or for ROCHE or any other CHIRON licensee in the
Field. ROCHE may have the benefit of the adjustment to Earned Royalty Amounts provided by this Paragraph 2 or the adjustment to Earned Royalty Amounts provided under Section 13.2, at its
election, but not both.

3.Pre-Licensing Royalties.Notwithstanding anything to the contrary in the Agreement or this
Exhibit A, Earned Royalties shall be paid on Units for investigational or other pre-licensure use.

4.Most Favored Licensee.CHIRON shall promptly notify ROCHE if it grants to a third party a license under
CHIRON Licensed Patents to (i) practice in Blood Screening or Plasma Fractionation under terms that impose[***]or
(ii)[***]. With such notification, CHIRON shall provide ROCHE with a summary of [***]. At ROCHE's election, to be made in writing[***]hereunder, or the[***], as applicable, shall be adjusted [***]. Any such adjustment will be subject to the same terms as are applicable to such minimum
amounts payable by such third
party, including, without limitation,[***]. This Paragraph 4 only applies to licenses that enable a third party to sell
or use Products Directed to

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HIV
for Blood Screening; provided, however, it does not apply to licenses of Products Directed to HIV for Blood Screening that do not compete with Products then being sold by ROCHE. It also does not
apply to a license that amends, replaces or supplements CHIRON's arrangement with[***].

5.Single Royalty Per CHIRON Licensed Product.Only one payment of Earned Royalty shall be due with respect to
any Net Sales or only one payment of Earned Royalty Amount shall be due with respect to any Unit of CHIRON Licensed Product Shipped, irrespective of the number of patents or Valid Claims in the CHIRON
Licensed Patents covering such CHIRON Licensed Product.

6.Dispute Resolution.Except as set forth in Paragraph 2 of this Exhibit A, any dispute between
CHIRON and ROCHE regarding whether any adjustment to or credits against Earned Royalties under this Exhibit A is appropriate, and which the parties fail to resolve themselves may only be
resolved by resort to the ADR provisions of Article 10. Until such dispute is resolved, ROCHE shall pay CHIRON the Earned Royalty provided for herein without benefit of the applicable disputed
adjustment on the condition that CHIRON shall repay ROCHE the amounts of such disputed payments if ROCHE prevails in the ADR, plus interest at the rate described in Section 4.9.

2

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Exhibit BBlood Screening  Page 1 of 1

[***]

[***]

[***]

[***]

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[***]Exhibit CHIV  Page 1 of 1

[***]

[***]

[***]

[***]

[***]

[***]

[***]

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EXHIBIT D

Product Codes, BS kits:

|Description |  | SAP/Part No.
|----------- |  | ------------
|           
|HIV         |  |             
|[***]       |  | [***]       
|[***]       |  | [***]       

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Exhibit E        Form of Report        [To Be Attached.]

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Exhibit F    Existing Licenses or Rights granted in the Field under the Licensed Patents as of the Effective Date

[***]

1.     Agreement
between Gen-Probe Incorporated and Chiron Corporation dated as of June 11, 1998 (the "Gen-Probe Agreement").

[***]

[***]

[***]

[***]

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