<Page>

                                                                   EXHIBIT 10.38
                                                       Confidential Treatment(1)


                                     LICENSE
                                    AGREEMENT
                                     BETWEEN
                            ANIKA THERAPEUTICS, INC.
                                       AND
                          ORTHO BIOTECH PRODUCTS, L.P.


----------
(1)  Redacted portions have been marked with brackets containing asterisks
([***]). The redacted portions are subject to a request for confidential
treatment and have been filed seperately with the Securities and Exchange
Commission.

<Page>

                                TABLE OF CONTENTS

<Table>
<Caption>
                                                                              PAGE
                                                                              ----
<S>                                                                             <C>
ARTICLE I - DEFINITIONS..........................................................2

ARTICLE II - PRODUCT DEVELOPMENT.................................................8

ARTICLE III - COMMERCIALIZATION.................................................10

ARTICLE IV - INTELLECTUAL PROPERTY LICENSE GRANTS...............................13

ARTICLE V - PAYMENTS............................................................13

ARTICLE VI - MANUFACTURE........................................................18

ARTICLE VII - PUBLICATIONS; TRANSFER OF DATA; CONFIDENTIALITY...................27

ARTICLE VIII - OWNERSHIP OF INTELLECTUAL PROPERTY AND PATENT RIGHTS.............29

ARTICLE IX - REPRESENTATIONS AND WARRANTIES.....................................32

ARTICLE X - ANIKA'S GENERAL OBLIGATIONS AND COVENANTS...........................34

ARTICLE XI - OBI's GENERAL OBLIGATIONS..........................................36

ARTICLE XII - TERM AND TERMINATION..............................................37

ARTICLE XIII - INDEMNIFICATION..................................................40

ARTICLE XIV - ADDITIONAL APPLICATIONS AND INDICATIONS...........................43

ARTICLE XV - STEERING COMMITTEE.................................................45

ARTICLE XVI - DISPUTE RESOLUTION................................................46

ARTICLE XVII - HSR FILING.......................................................46

ARTICLE XVIII - MISCELLANEOUS...................................................48
</Table>

                                       (i)
<Page>

This License Agreement (this "Agreement") is made effective as of December 20,
2003 by and between Anika Therapeutics, Inc., a Massachusetts corporation,
having a place of business at 160 New Boston Street, Woburn, Massachusetts 01801
("ANIKA"), and Ortho Biotech Products, L.P., a New Jersey limited partnership,
having a place of business at Route 22 East, P.O. Box 6914, Bridgewater, New
Jersey, 08807-0914 ("OBI"). ANIKA and OBI are each referred to by name or as a
"Party" or, collectively, as the "Parties." References to "ANIKA" and "OBI"
shall include their respective Affiliates (hereinafter defined), where
appropriate under the terms of this Agreement.

                                    RECITALS

        1.      ANIKA develops, manufactures and commercializes therapeutic
products and devices intended to promote the repair, protection and healing of
bone, cartilage and soft tissue.

        2.      On May 30, 2003, ANIKA submitted the third and final module of a
PMA to the FDA for HA for the treatment of pain associated with osteoarthritis
of the knee by intra-articular injection of such preparation.

        3.      OBI possesses research, development and commercialization
capabilities, as well as proprietary technology in a broad range of therapeutic
fields.

        4.      ANIKA desires to license its hyaluronic acid preparation
marketed as Orthovisc(R) to OBI so that OBI may develop, commercialize,
distribute and sell such preparation for indications and applications within the
Field and in the Territory as provided herein.

        5.      ANIKA also desires to supply Orthovisc(R) to OBI on an exclusive
basis for use by OBI in the commercialization of Orthovisc(R) pursuant to the
terms of this Agreement.

        6.      ANIKA and Pharmaceutical Sourcing Group Americas, an affiliate
of OBI, are entering into the Quality Agreement, in the form attached hereto as
Exhibit E, as of the date hereof.

        7.      Unless defined elsewhere in this Agreement, capitalized terms
used in this Agreement shall have the meanings set forth in Article I.

        NOW, THEREFORE, in consideration of the premises and mutual covenants
herein contained, and for other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the Parties hereto agree as
follows:

<Page>

                             ARTICLE I - DEFINITIONS

When used in this Agreement, each of the following terms, when capitalized in
their initials, shall have the meaning set forth below. The term shall have the
same meaning whether the singular or plural form is used.

"Active Ingredient" shall have the meaning set forth in Section 6.10(ii) of this
Agreement.

"Adverse Knowledge" shall have the meaning set forth in Section 6.10(iv) of this
Agreement.

"Affiliate" of a Party means any company or entity which controls, is controlled
by or is under common control with such Party, where control, for purposes of
this definition, means (i) the possession, directly or indirectly, of the power
to direct the management or policies of a Person or to veto any material
decision relating to the management or policies of a Person or a majority of the
composition of the board of directors (or similar governing body), in each case,
whether through the ownership of voting securities, by contract or otherwise, or
(ii) the Beneficial Ownership, directly or indirectly, of at least 50% of the
voting securities of a Person. "Beneficial Ownership" shall be determined in
compliance with Rule 13d-3 of the Securities Exchange Act of 1934.

"Agreement" shall have the meaning set forth in the first paragraph hereto.

"Alternative Supplier" shall have the meaning set forth in Section 6.10(i) of
this Agreement.

"Alternative Supplier Agreement" shall have the meaning set forth in Section
6.10(i) of this Agreement.

"ANIKA Area" shall have the meaning set forth in Section 3.3 of this Agreement.

"ANIKA Disclosure Date" shall have the meaning set forth in Section 14.1(b) of
this Agreement.

"ANIKA Know-How" means Information in ANIKA's Control, which is developed or
acquired by ANIKA, either as of the Effective Date or at any time during the
Term of this Agreement, which relates to the use of a Licensed Product in the
Field. Notwithstanding anything herein to the contrary, ANIKA Know-How excludes
ANIKA Patents.

"ANIKA Patents" means any patent granted by any governmental authority in any
jurisdiction within the Territory relating to a Licensed Product, which Patent
is Controlled by ANIKA during the term of this Agreement.

"ANIKA Potential Product" shall have the meaning set forth in Section 14.1(a) of
this Agreement.

"ANS" or "Annual Net Sales" means the Net Sales in a Calendar Year excluding
sales between Affiliates, and to distributors outside the United States.

                                        2
<Page>

"Audit" has the meaning set forth in Section 5.6(d) of this Agreement.

"Average Sales Price" shall have the meaning set forth in Section 6.2(a)(iii) of
this Agreement.

"Bankruptcy Code" has the meaning set forth in Section 18.16 of this Agreement.

"Branding Materials" has the meaning set forth in Section 3.2(j) of this
Agreement.

"Business Day" means a day on which banking institutions in New York, New York
are open for business.

"Calendar Quarter" means a quarter in a Calendar Year and as defined by the J&J
Universal Calendar.

"Calendar Year" means those twelve months as defined by the J&J Universal
Calendar.

"Claiming Party" shall have the meaning set forth in Section 13.6 of this
Agreement.

"CMS" means Center for Medicare Services.

"Competing Product" has the meaning set forth in Article XI (i) of this
Agreement.

"Confidential Information" shall have the meaning set forth in Section 7.1 of
this Agreement.

"Control" or "Controlling" means owned by or possesses the right to grant a
license or sublicense without violating the terms of any agreement with any
Third Party.

"Customers" has the meaning set forth in the definition of Net Sales in this
Article I.

"Date of First Sale" means the date on which OBI (or an Affiliate or any of
their distributors) first sells a Licensed Product to an unaffiliated Third
Party in an arms length commercial transaction.

"Develop" or "Development" means all activities relating to obtaining Regulatory
Approval of Licensed Products within the Field and Territory, including, but not
limited to, preclinical testing, toxicology, formulation, manufacturing process
development, quality assurance and quality control, pharmacokinetics, clinical
studies, Phase IV, development of kits and/or development of indications,
applications and/or formulations to the extent formulation development is
limited to optimization of the Licensed Product formulation such as formulation
modifications to reduce specific adverse events, to reduce volume of Licensed
Product per injection and to reduce the total number of injections by for
example increasing the concentration of HA or viscosity of HA solution; provided
that "Development" shall also mean any developments, inventions, processes,
methods or works of authorship which is created, developed, invented or reduced
to practice in connection with performing the foregoing described activities.

"Development Invention" shall have the meaning set forth in Section 8.1 of this
Agreement.

                                        3
<Page>

"Dispute" shall have the meaning set forth in Section 16.2 of this Agreement.

"Diverted Product" has the meaning set forth in Article X(a)(iii) of this
Agreement.

"DOJ" shall have the meaning set forth in Section 17.1 of this Agreement.

"Dollars" or "$" means lawful money of the United States in immediately
available funds.

"Domain Name Marks" shall have the meaning set forth in Section 3.3 of this
Agreement.

"Drug Approval Application" means an application for Regulatory Approval
required before commercial sale or use of a Licensed Product as a drug in a
regulatory jurisdiction.

"Effective Date" means the last date of execution of this Agreement referred to
above.

"Failure to Supply" shall have the meaning set forth in Section 6.10(i) of this
Agreement.

"FDA" means the United States Food and Drug Administration or any successor
agency.

"Field" means the treatment of pain in humans associated with osteoarthritis by
intra-articular injection.

"Filing Party" shall have the meaning set forth in Section 8.4(b) of this
Agreement.

"FTC" shall have the meaning set forth in Section 17.1 of this Agreement.

"GMP" means Good Manufacturing Practices as such term is generally understood in
the medical device industry.

"Governmental Antitrust Authority" shall have the meaning set forth in Section
17.1 of this Agreement.

"Gray Market Product" has the meaning set forth in Article X (a)(ii) in this
Agreement.

"HA" means a hyaluronic acid whether as an acid, a pharmaceutically acceptable
salt, or a mixture thereof, in any solid or solution phase form thereof,
including, but not limited to, a sterile, nonpyrogenic solution of sodium
hyaluronate in physiologic saline solution.

"HSR Act" shall have the meaning set forth in Section 17.4(a) of this Agreement.

"HSR Clearance Date" shall have the meaning set forth in Section 17.4(c) of this
Agreement.

"HSR Filing" shall have the meaning set forth in Section 17.4(b) of this
Agreement.

"Information" means technical information, techniques and data, whether in
writing or not, generally not known to the public, relating to the use of
Licensed Product in the Field and including techniques and data, including, but
not limited to, screens, models, inventions,

                                        4
<Page>

practices, methods, knowledge, know-how, skill, experience, test data including
pharmacological, toxicological and clinical test data, analytical and quality
control data, marketing, pricing, distribution, sales, manufacturing data, and
patent and legal data or descriptions.

"Initial Estimated Transfer Price" shall have the meaning set forth in Section
6.2(a)(i) of this Agreement.

"Initial Period" shall have the meaning set forth in Section 6.2(a)(i) of this
Agreement.

"Initial Report" shall have the meaning set forth in Section 6.2(a)(i) of this
Agreement.

"J Code" means a code issued pursuant to the HCFA Command Procedure Coding
System (HCPCS) recognized by Medicare carriers and Medicare agencies.

"J&J Universal Calendar means the annual calendar put forth by Johnson & Johnson
describing scheduled monthly, quarterly and yearly accounting periods for the
purposes of calculating net sales, royalty payments and sales based milestone
payments.

"Joint Patents" shall have the meaning set forth in Section 8.4(a) of this
Agreement.

"Licensed Product(s)" means products covered by ANIKA's PMA No. P030019 (i.e.
Orthovisc(R)), or products whose characteristics satisfy the Specifications. For
purposes of this Agreement, Licensed Product shall also include any product
Developed pursuant to Section 2.1(c).

"License Period" shall have the meaning set forth in Section 6.10(iii) of this
Agreement.

"Modified Licensed Product" shall have the meaning set forth in Section 8.9 of
this Agreement.

"Net Sales" means, consistent with, in the United States, generally accepted
accounting principles and, in the rest of the Territory, OBI worldwide practices
and procedures, and in each such case as consistently applied with respect to
all Licensed Products, the amount invoiced by OBI, its Affiliates, and its
distributors and sub-licensees to Customers for sales of Licensed Product in the
Territory, less accruals estimated, credits taken, and actual payments (to the
extent not previously accrued) made for: (i) discounts, including, but not
limited to, cash discounts, discounts to managed care or similar organizations
or government organizations, rebates paid, credited, accrued or actually taken,
including government rebates such as Medicaid charge backs or rebates, and
retroactive price reductions or allowances actually allowed or granted from the
billed amount, and commercially reasonable and customary fees paid to
wholesalers, buying groups, hospitals or physicians, excluding any distributors
or sub-licensees ("Customers"), (ii) credits or allowances actually granted upon
claims, rejections or returns of such sales of Licensed Products, including
recalls (provided such recalls are in accordance with Section 6.9 of this
Agreement and except to the extent ANIKA has otherwise paid for such recall),
(iii) taxes, duties or other governmental charges levied on or measured by the
billing amount when included in billing, as adjusted for rebates, charge-backs,
and refunds (and similar adjustments), (iv) actual

                                        5
<Page>

write-offs for uncollectable accounts, PROVIDED, HOWEVER, that if collected at a
later date, such amounts will be added to Net Sales, and (v) freight, postage,
shipping and insurance charges paid for delivery of such Licensed Products, to
the extent billed and reflected on the invoices. For purposes of calculating
"Net Sales," a Licensed Product shall be considered "sold" upon the invoicing of
such Licensed Product by OBI to a Third Party (other than to any of its
Affiliates), or upon invoicing of such Licensed Product by any of OBI's
Affiliates or distributors or sub-licensees to a Third Party.

"OBI Area" shall have the meaning set forth in Section 3.3 of this Agreement.

"OBI Disclosure Date" shall have the meaning set forth in Section 14.2(b) of
this Agreement.

"OBI Potential Products" shall have the meaning set forth in Section 14.2(a) of
this Agreement.

"OBI Sellers" means OBI, its Affiliates, sub-licensees and distributors.

"Patent" means (i) valid and enforceable patent, including any extension,
registration, confirmation, reissue, continuation, divisional,
continuation-in-part, re-examination or renewal thereof, and (ii) pending
applications for Letters Patents, in any jurisdiction within the Territory.

"Patent Costs" means the reasonable fees and expenses paid to outside legal
counsel and other Third Parties, and filing and maintenance expenses, incurred
in connection with the establishment and maintenance of rights under Patents.

"Person" shall mean any natural person, corporation, firm, limited liability
corporation, limited liability partnership, business trust, joint venture,
association, organization, company, partnership or other business entity, or any
government or any agency or political subdivision thereof.

"Per Unit Overpayment" shall have the meaning set forth in Section 6.2(a)(i) of
this Agreement.

"Per Unit Underpayment" shall have the meaning set forth in Section 6.2(a)(i) of
this Agreement.

"Phase IV" shall mean product support clinical trials of the Licensed Product
with an approved label claim commenced after receipt of Regulatory Approval in
the country where such trial is being conducted.

"PMA" means a premarket approval application filed with the FDA, or if a PMA is
not the appropriate filing, then the suitable filing required to obtain
Regulatory Approval. "PMA" includes the "Currently Filed PMA", which is ANIKA's
PMA No. P030019 for ORTHOVISC(R) presently under consideration by the FDA, as
may be supplemented, amended or augmented from time to time.

"Quality Agreement" has the meaning set forth in the recitals to this Agreement.

"R&D Pipeline" shall mean the research and development projects developed by
ANIKA.

                                        6
<Page>

"Raw Materials" shall mean the materials, components, and packaging required to
manufacture and package the Licensed Product in accordance with the
Specifications.

"Reference Quarter" shall have the meaning set forth in Section 6.2(a)(iii) of
this document.

"Regulatory Approval" shall mean all regulatory agency registrations and
approvals by government, pricing or health authorities in a country which are
required for first use or sale of a medical device or drug, including,
importation, manufacture (where manufacture is required) or use, in each case,
in the Field in the Territory.

"Replacement Product" shall have the meaning set forth in Section 5.2(a) of this
Agreement.

"Retained Sample" shall have the meaning set forth in Section 6.8 of this
Agreement

"Rolling Annual Forecast" shall have the meaning set forth in Section 6.3(a) of
this Agreement.

"Second Period" shall have the meaning set forth in Section 6.2(a)(ii) of this
Agreement.

"Second Period Per Unit Overpayment" shall have the meaning set forth in Section
6.2(a)(ii) of this Agreement.

"Second Period Per Unit Underpayment" shall have the meaning set forth in
Section 6.2(a)(ii) of this Agreement.

"Second Period Average Sales" shall have the meaning set forth in Section
6.2(a)(ii) of this Agreement.

"Second Report" shall have the meaning set forth in Section 6.2(a)(ii) of this
Agreement.

"Second Source Qualification" shall have the meaning set forth in Section
6.10(ii) of this Agreement.

"Shipping Point" shall have the meaning set forth in Section 6.6(b) of this
Agreement.

"Site" shall have the meaning set forth in Section 3.3 of this Agreement.

"Specifications" shall mean the specifications for the composition, manufacture,
packaging, and/or quality control of all Licensed Product, as set forth on
EXHIBIT A, attached hereto and made a part hereof, as the same may hereafter be
modified by mutual agreement of the Parties in writing and attached hereto as a
replacement for, or as an addition to, EXHIBIT A.

"Steering Committee" has the meaning set forth in Article 15 of this Agreement.

"Supply Year" shall mean Calendar Year.

                                        7
<Page>

"Term" shall mean the period commencing on the Effective Date and terminating on
the latest to expire of the effective periods of this Agreement with respect to
any country in the Territory as may be extended pursuant to Section 12.1 of this
Agreement.

"Territory" means the United States of America ("U.S."), and Mexico.

"Third Party" means any entity other than ANIKA, OBI or any Affiliates of ANIKA
or OBI.

"Total Initial Units" shall have the meaning set forth in Section 6.2(a)(i) of
this Agreement.

"Total Second Period Units" shall have the meaning set forth in Section
6.2(a)(ii) of this Report.

"Trademark" has the meaning set forth in Section 3.2(a)(i) of this Agreement.

"Unit" shall mean each syringe containing Licensed Product.

"Unit Price" shall have the meaning set forth in Section 6.2(a) of this
Agreement.

"Validity Challenge Claim" shall have the meaning set forth in Section 8.6(i) of
this Agreement.

"Vision System" means an automated system that reads information (either
printing or bar codes).


                        ARTICLE II - PRODUCT DEVELOPMENT

2.1.    DEVELOPMENT RESPONSIBILITIES.

        (a)     UNITED STATES. With respect to the Currently Filed PMA for
Licensed Product by ANIKA, ANIKA shall use commercially reasonable efforts
consistent with its normal business practices to obtain Regulatory Approval with
the FDA. ANIKA shall be solely responsible for obtaining such Regulatory
Approval, at its sole cost and expense. ANIKA shall on a regular basis report to
OBI on the progress of its efforts in obtaining such Regulatory Approval.

        (b)     MEXICO. OBI shall have the right but not the obligation to file
a Drug Approval Application in Mexico, at its sole cost and expense. Prior to
making any decision on whether to file for Regulatory Approval in Mexico of
Licensed Product, OBI shall discuss the matter through the Steering Committee. A
decision of whether to file for Regulatory Approval and/or launch Licensed
Product in Mexico is required to be mutually agreed upon by the Parties in
advance of any filing. Subject to the foregoing, should OBI proceed with such
filing of a Drug Approval Application in Mexico, ANIKA shall cooperate with the
preparation and execution of such Drug Approval Application. OBI agrees to name
ANIKA as the approved supplier of the Licensed Product in any such filings.
ANIKA shall have sole ownership rights in any such Drug Approval Application in
Mexico, notwithstanding OBI's participation in the filing thereof. If by the end
of the second quarter of 2005 OBI has failed to commence material and concerted
efforts to market and commercialize Licensed Product in Mexico, and if the
Steering Committee has

                                        8
<Page>

determined that commercialization of Licensed Product will not materially impair
the sales of Licensed Product in the United States, then OBI shall immediately
forfeit its rights and licenses under this Agreement with respect to any
Licensed Product in Mexico, all such rights and licenses (including distribution
rights), with respect to such Licensed Product in Mexico shall revert to or
remain with ANIKA (as the case maybe), and all references to "Territory" herein
will automatically exclude Mexico.

        (c)     GENERAL. OBI shall have the exclusive right to Develop Licensed
Product in the Territory in the Field by carrying out clinical trials in the
Territory. Prior to making any decision on whether to so Develop Licensed
Product, OBI shall discuss the matter through the Steering Committee. OBI agrees
to carry out such Development of any Licensed Product in the Territory and Field
consistent with its normal business practices regarding a product of similar
commercial potential. OBI hereby grants ANIKA the exclusive right to copy,
modify, distribute and use any such new Developments or Information created or
Development in connection with such Development outside the Territory including
the right to cross reference any OBI Regulatory Approvals and use the data and
Information contained therein at a cost equal to half of OBI's fully allocated
Development costs associated with any such new Development used by ANIKA. OBI
agrees to in good faith begin a clinical trial for a new indication for such
Licensed Product or a Phase IV clinical trial within 12 months from receipt of
approval of the Currently Filed PMA from the FDA unless otherwise mutually
agreed to by the Parties.

2.2.    OWNERSHIP AND OBTAINING OF DRUG APPROVAL APPLICATIONS AND REGULATORY
        APPROVALS.

        With respect to all Regulatory Approvals, including the Currently Filed
PMA and supplements thereto directed to new indications and formulations
Developed by OBI hereunder, ANIKA shall have sole ownership rights in any
Regulatory Approval received and all relevant documents associated with the
Regulatory Approval and corresponding Drug Approval Application materials;
provided, however, that ANIKA shall be permitted to assign or license such
ownership rights to OBI in ANIKA's sole discretion. Except to the extent
explicitly provided for in this Agreement, ANIKA will not be required to conduct
any clinical trials and or other studies in connection with any Regulatory
Approval and ANIKA's only obligation in connection herewith is to use
commercially reasonably efforts to prepare and file applicable agency
registrations and approvals. Notwithstanding anything to the contrary contained
herein, upon reasonable request by OBI, ANIKA agrees to set up a meeting or
initiate contact with the FDA in connection with Licensed Product. In such
meeting or contact, OBI shall be permitted to communicate and interact directly
with the FDA in connection with obtaining a Regulatory Approval from the FDA;
provided that (a) OBI shall, notify ANIKA in advance of such desired
communications or interaction (including the probable substance thereof); (b)
ANIKA facilitates and coordinates such communications or interaction; and (c) a
representative of Anika shall be present for and participate during such
communications or interaction.

                                        9
<Page>

                         ARTICLE III - COMMERCIALIZATION

3.1.    OBI'S MARKETING OBLIGATIONS FOR LICENSED PRODUCTS.

        All business decisions related to, the sale, price and promotion of
Licensed Products under this Agreement and the decisions whether to market or
not market any particular Licensed Product shall be within the sole discretion
of OBI. To the extent permitted in Section 15(e), the Steering Committee shall
review and comment on the relevant marketing and sales activities. Any marketing
or commercialization of a Licensed Product in one country within the Territory
shall not obligate OBI to market or commercialize said Licensed Product in any
other country. Furthermore, subject to Article IX and XI of this Agreement, OBI
makes no representation, warranty or covenant that the marketing of a Licensed
Product shall be the exclusive means by which OBI will participate in any
therapeutic field. In commercializing any Licensed Product, OBI will use
reasonable commercial efforts that are consistent with the efforts it uses in
commercializing its own pharmaceutical products.

3.2.    TRADEMARKS.

        (a)

                (i)       ANIKA hereby grants to OBI for the Term of this
        Agreement the exclusive, royalty-free right to use the trademark
        "Orthovisc(R)" (the "Trademark") only in connection with the marketing,
        distribution and sale of Licensed Product in the Territory and only in
        the Field. OBI expressly agrees that it will label all packaging
        containing the Licensed Product with the following designation,
        "Orthovisc(R) is a trademark of ANIKA Therapeutics, Inc.," and will sell
        all Licensed Product only under the trademark "Orthovisc(R)." ANIKA
        agrees that it will not use or give rights to a Third Party to use the
        Trademark in the Territory in connection with any other product. OBI
        agrees that all of its use of the Trademark will inure to the benefit of
        ANIKA.

                (ii)      OBI shall not use any trademark, service mark, trade
        name, logo, internet domain name or design which is the same or
        substantially similar to Trademark as such to cause confusion in the
        mind of a reasonable person.

                (iii)     All costs and expenses incurred with respect to the
        preparation of Trademark applications, and with respect to the filing
        and/or maintenance of Trademark registrations and other documentation
        required by government agencies shall be paid by ANIKA. OBI shall assist
        and cooperate with ANIKA in connection with the filing and/or
        maintenance of any such Trademark registrations and other documentation
        required by government agencies in the Territory as may be reasonably
        requested by ANIKA from time to time.

                (iv)      In the event OBI desires to market the Licensed
        Product under a trademark other than "Orthovisc," utilization of such
        alternative trademark shall be subject to the approval of ANIKA. OBI
        shall be fully responsible at its sole cost for obtaining such

                                       10
<Page>

        alternative trademark and shall own such trademark. ANIKA shall have no
        rights to use such trademark outside the Territory.

        (b)     OBI will supply ANIKA with samples of its use of Trademark upon
ANIKA's request.

        (c)     OBI shall use the Trademark only in a manner and form designed
to maintain the high quality of the Trademark. If ANIKA at any time finds that
OBI's or any of its sublicensee's or distributor's use of the Trademark is not
consistent with standards of quality acceptable to ANIKA, ANIKA may notify OBI
in writing of such deficiencies, and if OBI fails to correct such deficiencies
within sixty days after receipt of such notice, ANIKA, may, at its election,
terminate the license granted in Section 3.2(a)(i) immediately.

        (d)     OBI may not sublicense, other than to an Affiliate of OBI, the
Trademark to any Third Party without ANIKA's prior written consent; provided
that any permitted sublicensee must agree to be bound by the terms and
conditions of this Section 3.2.

        (e)     ANIKA reserves all other rights in and to the Trademark,
including, without limitation, the right to license the Trademark in all
countries outside the Territory.

        (f)     OBI shall never challenge ANIKA's ownership of or right to
license, or the validity of, the Trademark or any application for registration
thereof or any trademark registration thereof. OBI shall never file any
application for a registration for the Trademark in any office or agency
anywhere in the world.

        (g)     Each of the Parties shall promptly notify the other Party of any
infringement of the Trademark by a Third Party in the Territory and cooperate
with each other in deciding how to proceed. If the Trademark is infringed by a
Third Party in the Territory, ANIKA shall either (i) bring an action for
infringement, at its sole expense, against such third party, in which case ANIKA
shall be entitled to any and all proceeds resulting from such action, and shall
keep OBI informed as to the prosecution of the action; or (ii) notify OBI in
writing that it will not pursue an infringement action against the Third Party.
In the event ANIKA exercises option (ii) in the immediately preceding sentence,
OBI shall either (i) bring an action for infringement, at its sole expense,
against such Third Party, in which case OBI shall be entitled to any and all
proceeds resulting from such action, and shall keep ANIKA informed as to the
prosecution of the action; or (ii) notify ANIKA in writing that it will not
pursue an infringement action against the third party. In the event OBI
exercises option (ii) in the immediately preceding sentence, the Steering
Committee shall meet within ten (10) days of OBI's receipt of ANIKA's
notification to determine whether the third party infringement prevents OBI from
competing effectively in the affected market(s) and, if so, how best to proceed.

        (h)     If a Third Party asserts that a trademark owned by it is
infringed by the use of Orthovisc(R) by OBI in the Territory in accordance with
this Agreement, ANIKA a has an obligation under to defend against such assertion
or resulting litigation within thirty (30) days after receiving written notice
thereof, and OBI shall assist and cooperate with ANIKA in the

                                       11
<Page>

defense of such suit. ANIKA shall bear the full costs and expenses of such
defense and shall assume full responsibility for the payment of any award for
damages, or any amount due pursuant to any settlement entered into by ANIKA.
ANIKA shall not enter into any settlement, consent decree or other voluntary
final disposition of the suit without the prior written notice to OBI, and OBI
is not responsible in any way whatsoever for any such settlement or compromise
entered into without such prior written consent.

        (i)     Upon termination of this Agreement for any reason, the license
granted in this Section 3.2 shall immediately terminate, and OBI and all of its
sublicensees shall immediately cease all use of the Trademark.

        (j)     BRANDING MATERIALS. OBI shall bear the costs associated with its
efforts to establish and promote the Orthovisc(R) brand in the Territory, as set
out in any marketing plan(s) reviewed by the Steering Committee. The Parties
agree that the materials and information developed by OBI for this purpose (the
"Branding Materials"), are the sole property of OBI. As used herein, the term
"Branding Materials" includes without limitation promotional, training, and
public relations materials, trademarks, slogans, advertising tag lines, logos
and other trade dress, whether in print, video or other format (including,
without limitation, the content contained in the website referred to in Section
3.3), but expressly excludes the Trademark, any logo, and "trade dress" of the
Licensed Product's package, which is licensed to OBI hereunder, which Trademark,
logo and trade dress shall be the sole property of ANIKA. ANIKA may elect to
purchase from OBI a paid-up perpetual license to sell, sublicense, reproduce,
modify distribute any or all of the Branding Materials for use outside the
Territory, provided ANIKA shall have no right to purchase OBI trademarks and
logos, and other Branding Materials, which Branding Materials are used to
promote other OBI products. If ANIKA so elects, OBI shall provide one copy of
the digital file containing the Branding Materials ANIKA has selected, and ANIKA
shall pay to OBI within 45 days after receipt of the digital file a one-time fee
equal ten percent (10%) of OBI's documented Third Party hard costs for
conceptualization, preproduction, and production of the selected Branding
Materials (excluding printing costs).

3.3.    Subject to the terms and conditions of this Agreement, ANIKA hereby
grants to OBI for the Term of this Agreement the exclusive, non-sublicensable,
royalty-free right to use the domain name orthovisc.com. OBI shall have the sole
authority to create and post content on the Territory portion of any website
identified by the orthovisc.com domain name, and all such content, including
copyrights therein, shall belong to OBI. ANIKA shall maintain the orthovisc.com
domain name registration in good order for the duration of this Agreement and
any extensions thereof. OBI will, at its cost, design, develop, host, operate
and maintain a web site located at www.orthovisc.com, (the "Site") which will,
among other things, market and promote Licensed Product. ANIKA shall have the
right, at its cost, to develop, launch and update an ANIKA branded area on the
Site (the "ANIKA Area") which targets users outside of the Territory. OBI will
cooperate with ANIKA in connection with the development, launch and updating of
the ANIKA Area, including, but not limited to modifying the Site from time to
time to incorporate ANIKA Area content delivered by ANIKA. The orthovisc.com
website will be constructed in a manner so as to allow visitors to be directed
to either the OBI portion of the website, which will relate to the Territory
(the "OBI Area"), and to the ANIKA Area, which will relate to the ANIKA

                                       12
<Page>

regions of the world excluding the Territory. Reference herein to OBI's
authority to create and post content on the orthovisc.com website only relates
to the portion or link relating to the OBI Area. OBI acknowledges and agrees
that (a) OBI has no right, title and/or interest in the orthovisc.com domain
name, or any trademarks, trade names and service marks that may be contained in
the orthovisc.com domain name (collectively, "Domain Name Marks"), other than
the limited license granted in this Section 3.3, (b) all rights arising from
OBI's use of the Domain Name Marks inure to the benefit of ANIKA, (c) OBI will
only use the orthovisc.com domain name and any website identified by such domain
name for lawful purposes only and (d) upon termination of this Agreement, OBI
shall immediately discontinue all use of the orthovisc.com domain name.


                ARTICLE IV - INTELLECTUAL PROPERTY LICENSE GRANTS

4.1.    ANIKA hereby grants to OBI an exclusive, non-transferable royalty
bearing, license under ANIKA Know-How and ANIKA Patents in the Territory solely
to use and sell Licensed Products in the Field in the Territory, with a right to
grant sublicenses (to sublicensees and distributors), provided, however, (a) in
the United States, OBI may only grant sublicenses to Affiliates or, if approved
in advance in writing by ANIKA, to Third Parties and, (b) OBI may grant
sublicenses in Mexico to its Affiliates or to Third Parties who are OBI's
customary historical normal course distributors in accordance with past
practice, without prior notice or approval by ANIKA, and to non-customary
distributors only upon prior written notice or approval by ANIKA, which will not
be unreasonably withheld; provided, however, that any such sublicensee or
distributor shall be responsible for marketing and promotion of such Licensed
Product within the distribution territory. With respect to any such sublicensees
or distributors, OBI shall be responsible for making any payments due under this
Agreement to ANIKA resulting from sales made by such sublicensees or
distributors and the compliance by sublicensees or distributors with all
applicable terms of this Agreement.


                              ARTICLE V - PAYMENTS

        In consideration of the rights and licenses granted under this
Agreement, OBI agrees to pay ANIKA the following non-refundable amounts:

5.1.    UPFRONT PAYMENT.

        OBI agrees to pay to ANIKA a non-refundable upfront payment of two
million dollars ($2,000,000) within 5 Business Days of the Effective Date.

5.2.    PAYMENT EVENTS

        (a)     OBI agrees to make the following non-refundable payments to
ANIKA under this Section 5.2 upon the first occurrence of each event for the
first Licensed Product. If the first Licensed Product is replaced by another
Licensed Product (a "Replacement Product"), OBI shall not be obligated to make
the same event payments for the Replacement Product as it already

                                       13
<Page>

made in connection with the first Licensed Product which was replaced. It is
understood that in no event shall OBI be obligated to make the payment due on
any event more than once with respect to the same Licensed Product (or its
Replacement Product) in connection with any indication, application,
formulation, and/or use, regardless of the number of any of such indications,
applications, formulations and/or uses.

        (b)     Within twenty (20) Business Days following receipt from ANIKA of
a notice and invoice regarding the achievement of each of the following events
in connection with the Currently Filed PMA for Licensed Product as follows:

                (i)       [*****************************************************
        ************************************];

                (ii)      [*****************************************************
        ************************************];

                (iii)     [*****************************************************
        ************************************]

                (iv)      [*****************************************************
        ************************************************************************
        ************************************************************************
        *****************]

        For avoidance of doubt, if each of the items (i)-(iv) above were
        achieved, ANIKA would receive a total of thirty two million five-hundred
        thousand dollars ($32,500,000).

        (c)     Provisions (i)-(iii) in this subsection 5.2(c) as set forth
below refer to Annual Net Sales ("ANS") in the Territory:

                (i)       Referring to the 2005 ANS, either, and only one of,

                (i)(1)    if such 2005 ANS exceed [*****************************
        ****], OBI agrees to pay ANIKA [****************************************
        ****], or

                (i)(2)    if such 2005 ANS exceed [*****************************
        *****], OBI agrees to pay ANIKA [***************************************
        *********** *********],

                within thirty (30) Business Days from the end of the 2005
        Calendar Year;

                (ii)      Referring to the 2006 ANS, either, and only one of,

                (ii)(1)   if such 2006 ANS exceed [*****************************
        ****], OBI agrees to pay ANIKA [****************************************
        ********* ************], or

                                       14
<Page>

                (ii)(2)   if such 2006 ANS exceed [*****************************
        *], OBI agrees to pay ANIKA [*******************************************
        ****],

                within thirty (30) Business Days from the end of the 2006
        Calendar Year; and

                (iii)     Referring to the 2008 ANS, either, and only one of,

                (iii)(1)  if such 2008 ANS exceed [****************************
        **], OBI agrees to pay ANIKA [******************************************
        *], or

                (iii)(2)  if such 2008 ANS exceed [*****************************
        **], OBI agrees to pay ANIKA [******************************************
        ****],

                within thirty (30) Business Days from the end of the 2008
        Calendar Year.

5.3.    EARNED ROYALTIES FOR LICENSED PRODUCTS. In addition to any payments
pursuant to Section 5.2 of this Agreement, ANIKA shall be entitled to the
following royalty payments:

        (a)     With respect to each Calendar Year (including 2004), OBI shall
pay ANIKA a royalty according to the following Net Sales:

                (i)       For the portion of ANS in the Territory up to
        [*****************], a royalty of [******************] on such portion
        of Net Sales during such Calendar Year; PLUS

                (ii)      For the portion of ANS in the Territory that is in
        excess of [***********] up to and including [******************], a
        royalty of [***********************] on such portion of Net Sales during
        such Calendar Year; PROVIDED HOWEVER, if [**********************], such
        royalty shall be [*****************************] on such portion of Net
        Sales during such Calendar Year and each subsequent Calendar Year; PLUS

                (iii)     For the portion of ANS in the Territory that is in
        excess of [**********], a royalty of [**********************] on such
        portion of Net Sales during such Calendar Year.

        (b)     Royalties shall be paid in respect of all Licensed Products in
the Territory for the entire Term of this Agreement, including extensions or
renewals thereof.

5.4.    THIRD PARTY PATENTS.

        If a Patent or Patents of a Third Party should be in force in any
country in the Territory during the term of this Agreement covering the use or
sale of any Licensed Product, and if after receiving such notice from such Third
Party it should prove in OBI's reasonable judgment after consultation with
ANIKA, impractical or impossible for OBI or any OBI Affiliate to continue
performing the activity or activities licensed hereunder without obtaining a
royalty bearing

                                       15
<Page>

license from such Third Party under such Patent or Patents in said country, then
OBI shall promptly notify ANIKA in writing. If ANIKA agrees that a license is
required it shall use commercially reasonable efforts to procure such license
from the Third Party at its cost paying any compensation to such Third Party for
such license. If ANIKA disagrees that such a license is required, the Parties
shall submit the issue to an independent patent attorney selected mutually by
the Parties to determine whether a license is needed. The decision of such
patent attorney shall be final and to the extent that such patent attorney
decides that a license is required, ANIKA will use commercially reasonable
efforts to procure such license from the Third Party at its cost. The cost of
such patent attorney shall be borne by the non-prevailing party in the
disagreement.

5.5.    CURRENCY RESTRICTIONS.

        Except as herein provided in this Section 5.5, all royalties and
milestones shall be paid in Dollars. If, at any time, legal restrictions prevent
the prompt remittance of part of or all royalties and milestones with respect to
any country where Licensed Products are sold, OBI shall document such
restrictions to ANIKA and shall then have the right and option to make such
payments by depositing the amount thereof in local currency to ANIKA's accounts
in a bank or depository designated by ANIKA in such country.

5.6.    REPORTS AND RECORDS.

        (a)     During the Term of this Agreement and commencing with the Date
of First Sale of a Licensed Product, OBI shall furnish, or cause to be furnished
to ANIKA, written reports, including the calculation of royalty payment due,
within thirty (30) Business Days following the end of each Calendar Quarter,
showing:

                (i)       the Net Sales of each Licensed Product sold by each of
        OBI, its Affiliates and its Sublicensees in each country of the
        Territory, during the Calendar Quarter and the total for all quarters of
        the current Calendar Year;

                (ii)      the Units of each Licensed Product sold by each of
        OBI, its Affiliates and its Sublicensees in each country of the
        Territory, during the Calendar Quarter and the total for all quarters of
        the current Calendar Year;

                (iii)     the royalties payable in Dollars, which shall have
        accrued hereunder in respect to such Net Sales for the current Calendar
        Year; and

                (iv)      a detailed calculation of Net Sales for the Calendar
        Quarter and the total amount of Net Sales for the current Calendar Year
        through the most recently completed Calendar Quarter.

        (b)     All royalty payments to be made by OBI to ANIKA under Section
5.3 shall be made in Dollars by same day wire transfer no later than forty (40)
Business Days from the end of the applicable Calendar Quarter.

                                       16
<Page>

        (c)     In the case of sales outside the United States, for the purpose
of this Article 5, such sales shall be converted to Dollars in accordance with
OBI's current customary and usual procedures for calculating same which are the
following: the rate of currency conversion shall be calculated using a simple
monthly period average of the end "spot rates" provided by Brown Brothers
Harriman, 59 Wall Street, NY, NY 10005, for each Calendar Quarter, or if such
rates are not available, the same computation using the spot rates as published
by a leading United States commercial bank for such accounting period. These
methods of conversion are consistent with OBI's current accounting methods. OBI
shall give ANIKA prompt written notice of any proposed changes to OBI's
customary and usual procedures for currency conversion, which shall only apply
after such notice has been delivered to and approved by ANIKA, provided that
such changes continue to maintain a set methodology for currency conversion.

        (d)     Each report shall be made within thirty (30) Business Days from
the end of each calendar quarter. OBI shall keep accurate records in sufficient
detail to enable royalties and other payments payable hereunder to be
determined. OBI shall be responsible for all royalties and late payments that
are due to ANIKA that have not been paid by OBI, its Affiliates, its
sublicensees and distributors. All costs of enforcing or collecting payment
hereunder, including attorney's fees and court costs, shall be paid by the
non-prevailing Party.

        OBI shall maintain complete and accurate records, in accordance with
U.S. generally accepted accounting practices, which are relevant to costs,
expenses and payments under this Agreement and such records shall be open during
reasonable business hours for a period of five (5) years from creation of
individual records for examination at ANIKA's expense and not more often than
once each year by a certified public accountant or other representative selected
by ANIKA and acceptable to OBI for the sole purpose of verifying the correctness
of calculations or such costs, expenses or payments made under this Agreement
(the "Audit"). If OBI disagrees with the calculation of the Audit, and OBI and
ANIKA cannot resolve their disagreement, the matter shall be submitted to
arbitration in accordance with Article XVI. In the absence of material
discrepancies (in excess of 5% of the disputed amount) in any request for
reimbursement resulting from such audit, the accounting expense shall be paid by
ANIKA. If material discrepancies do result, OBI shall bear the reasonable audit
expense. Any records or accounting information received from OBI shall be
Confidential Information for purposes of Article VII.

5.7.    TAXES.

        (a)     OBI will make all payments to ANIKA under this Agreement without
deduction or withholding for taxes except, solely with respect to sales of
Licensed Product in Mexico, to the extent that any such deduction or withholding
is required by law in effect at the time of payment.

        (b)     Solely with respect to sales of Licensed Product in Mexico, any
tax required to be withheld on amounts payable under this Agreement will
promptly be paid by OBI on behalf of ANIKA to the appropriate governmental
authority, and OBI will furnish ANIKA with proof of

                                       17
<Page>

payment of such tax. Any such tax required to be withheld will be an expense of
and borne by ANIKA.

        (c)     OBI and ANIKA will cooperate with respect to all documentation
required by any taxing authority or reasonably requested by OBI or ANIKA to
secure a reduction in the rate of applicable withholding taxes solely with
respect to sales of Licensed Product in Mexico.

        (d)     If OBI had a duty to withhold taxes in connection with any
payment it made to ANIKA under this Agreement but OBI failed to withhold, and
such taxes were assessed against and paid by OBI, then ANIKA will indemnify and
hold harmless OBI from and against such taxes. If OBI makes a claim under this
Section 5.7(d), it will comply with the obligations imposed by Section 5.7(b) as
if OBI had withheld taxes from a payment to ANIKA.


                            ARTICLE VI - MANUFACTURE

6.1.    SUPPLY OF PRODUCTS.

        Subject to the Terms of this Agreement, during the term of this
Agreement, ANIKA agrees to supply OBI with those quantities of Licensed Product
as ordered by OBI pursuant to this Agreement, and OBI shall purchase from ANIKA
100% of OBI's requirements for Licensed Products to be sold in the Territory
subject to the ordering procedures set forth in Article VI.

6.2.    PRICES FOR PRODUCT.

        (a)     TRANSFER PRICES. The price for each Unit of Licensed Product
sold by ANIKA to OBI shall be set at [***] of the Unit Price (as defined below);
PROVIDED, HOWEVER, in no event shall [***] of the Unit Price be less than [***].
"Unit Price" is hereby defined as follows:

                (i)       FIRST CALENDAR QUARTER. The Unit Price for the period
        from the Date of First Sale until the last day of the first Calendar
        Quarter ended immediately following the Date of First Sale (the "Initial
        Period"), shall be the Initial Average Sales Price for such Initial
        Period where "Initial Average Sales Price" shall mean the fraction the
        NUMERATOR of which is the total Net Sales during such Initial Period and
        the DENOMINATOR of which is the total Units sold by the OBI Sellers
        during such Initial Period (the "Total Initial Units"). As the Unit
        Price for such Initial Period cannot be determined until after the end
        of such Initial Period, ANIKA shall invoice OBI at a transfer price
        equal to [***] of OBI's published list price ("Initial Estimated
        Transfer Price") for Units sold during such Initial Period.

        Within ten (10) days following the end of such Initial Period, OBI will
        provide ANIKA with a report containing the Net Sales for such Initial
        Period and the total Units sold during such Initial Period (the "Initial
        Report"). Within ten (10) days following the receipt of the Initial
        Report, (A) if the Initial Average Sales Price is greater than the
        Initial Estimated Transfer Price (such difference, the "Per Unit
        Underpayment"), OBI shall pay to ANIKA the product of (1) the Per Unit
        Underpayment and (2) the Total Initial Units,

                                       18
<Page>

        and (B) if the Initial Estimated Transfer Price is greater than the
        Initial Average Sales Price (such difference, the "Per Unit
        Overpayment"), ANIKA shall pay to OBI the product of (a) the Per Unit
        Overpayment and (b) the Total Initial Units, but in no event shall ANIKA
        pay any such amount to the extent such payment would result in ANIKA
        retaining a Unit Price of less than [***].

                (ii)      SECOND CALENDAR QUARTER. The Unit Price for the
        Calendar Quarter immediately succeeding the Initial Period (the "Second
        Period") shall be the Second Period Average Sales Price for such Second
        Period where "Second Period Average Sales Price" shall mean the fraction
        the NUMERATOR of which is the total Net Sales during such Second Period
        and the DENOMINATOR of which is the total Units sold by the OBI Sellers
        during such Second Period (the "Total Second Period Units"). As the Unit
        Price for such Second Period cannot be determined until after the end of
        such Second Period, ANIKA shall invoice OBI at a transfer price equal to
        Initial Estimated Transfer Price for Units sold during such Second
        Period.

        Within ten (10) days following the end of such Second Period, OBI will
        provide ANIKA with a report containing the Net Sales for such Second
        Period and the total Units sold during such Second Period (the "Second
        Report"). Within ten (10) days following the receipt of the Second
        Report, (A) if the Second Period Average Sales Price is greater than the
        Initial Estimated Transfer Price (such difference, the "Second Period
        Per Unit Underpayment"), OBI shall pay to ANIKA the product of (1) the
        Second Period Per Unit Underpayment and (2) the Total Second Period
        Units, and (B) if the Initial Estimated Transfer Price is greater than
        the Second Period Average Sales Price (such difference, the "Second
        Period Per Unit Overpayment"), ANIKA shall pay to OBI the product of (a)
        the Second Period Per Unit Overpayment and (b) the Total Second Period
        Units, but in no event shall ANIKA pay any such amount to the extent
        such payment would result in ANIKA retaining a Unit Price of less than
        [***].

                (iii)     SUBSEQUENT CALENDAR QUARTERS. The Unit Price for each
        Calendar Quarter ended after the Second Period shall be the Average
        Sales Price determined from the Calendar Quarter ended two Calendar
        Quarters immediately preceding such Calendar Quarter (the "Reference
        Quarter") (for instance, in the case of Q4, the Calendar Quarter ended
        two Calendar Quarters immediately preceding would be Q2), where "Average
        Sales Price" shall mean the fraction the NUMERATOR of which is the total
        Net Sales during such Reference Quarter and the DENOMINATOR of which is
        the total Units sold by the OBI Sellers during such Reference Quarter.

        Within five (5) Business Days following the end of each Calendar
        Quarter, OBI shall provide ANIKA with a preliminary and unaudited report
        containing the Net Sales for each such Calendar Quarter. These
        preliminary and unaudited reports will be superceded by the reports
        under Section 5.6(a) at the time those reports are required to be
        furnished.

        (b)     PAYMENT TERMS. Payment terms on all orders of Licensed Product
shall be forty-five (45) days net of invoice date. OBI shall keep accurate
records in sufficient detail to enable

                                       19
<Page>

transfer fees and other payments payable hereunder to be determined. OBI shall
be responsible for all transfer prices and late payments that are due to ANIKA.
Any past due amounts will be subject to a late fee of 1% per month, or the
highest rate allowed by law, whichever is less, with such interest accrual
commencing on the thirtieth day after the end of the month such payment was due.
All costs of enforcing or collecting payment hereunder, including attorney's
fees and court costs, shall be paid by the non-prevailing Party. Breach for
non-payment commences on the forty-sixth day following shipment of the Product
by ANIKA, assuming all invoice data from ANIKA is accurate.

6.3.    FORECASTS, ORDERS.

        (a)     Prior to the beginning of each Calendar Quarter during the term
of this Agreement, OBI shall provide ANIKA with a non-binding written forecast
of OBI's expected requirements for Licensed Products during the following twelve
months, designated M1-M12 and broken down by months and which shall include
order dates, quantity and shipping dates ("Rolling Annual Forecasts"). As
pertains for each Rolling Annual Forecast, the forecast for months designated
M7-M9, once set, may only be increased or decreased by up to 50% in the
aggregate from the original forecast for such month as the forecast is rolled
forward at the beginning of the next quarters, unless otherwise agreed to by
ANIKA. By way of example, assume the following four annual rolling forecast.

<Table>
<Caption>
   FORECAST             M1-M3                 M4-M6                  M7-M9               M10-M12
----------------------------------------------------------------------------------------------------
      <S>           <C>                    <C>                   <C>                  <C>
      1              Jan - March           April - June           JULY - SEPT          Oct. - Dec.
      2             April - June           July - Sept            OCT. - DEC.          Jan - March
      3              July - Sept           Oct. - Dec.            JAN - MARCH         April - June
      4              Oct. - Dec.           Jan - March           APRIL - JUNE          July - Sept
</Table>

Assume during Forecast 1, the forecast for July - September was 100 Units.
Accordingly, in each of Forecasts 2 and 3, the maximum forecast for
July-September is 150 Units and the minimum forecast for July-September is 50
Units.

The initial Rolling Annual Forecast shall be delivered by OBI within 2 weeks of
the Effective Date of the Agreement.

        (b)     ORDERS. The initial launch and inventory build quantities will
be exempt from this schedule, and determined by mutual agreement between ANIKA
and OBI. OBI shall place any binding orders for Licensed Product by written or
electronic purchase order (or by any other means agreed to by the Parties) to
ANIKA, which shall be placed at least 3 months prior to the desired date of
delivery and shall be consistent with the forecast provided for such Calendar
Quarter in the latest Rolling Annual Forecast. The Parties acknowledge that OBI
is not obligated to buy any specific amount of Licensed Product under this
Agreement, except for the quantities which OBI shall actually order through such
binding purchase orders in compliance with this Section 6.3(b).

                                       20
<Page>

        (c)     CONFLICTS. To the extent of any conflict or inconsistency
between this Agreement and any purchase order, purchase order release,
confirmation, acceptance or any similar document, the terms of this Agreement
shall govern.

6.4.    MOST FAVORED CUSTOMER.

        In consideration of the arrangements provided in this Agreement for the
OBI to purchase Licensed Product exclusively from ANIKA, ANIKA agrees that
during the term of this Agreement OBI shall be treated with "most favored
nation" status in connection with allocation of HA for manufacturing Licensed
Product, and, accordingly, if ANIKA is unable to supply all of the quantities of
Licensed Product ordered by OBI pursuant to binding orders in accordance with
this Agreement, ANIKA shall not provide any other customer (which customer is
similarly situated or purchases equivalent or less volume of products from ANIKA
than OBI in the aggregate) with preferential or more favorable treatment with
respect to allocation of Licensed Product (taking into account reasonable
forecasts, past sales and sales performance against forecast).

6.5.    IMPROVEMENTS.

        (a)     CHANGE IN SPECIFICATIONS. Either Party shall have the right to
request a change to the Specifications or packaging of Licensed Product during
the Term of this Agreement. In such event, the Party wishing to request a change
shall notify the other Party of its request in writing. If the receiving Party
agrees to such request, the Parties shall cooperate with each other to have such
change to the Specifications or packaging of Licensed Product approved by the
FDA, if such approval is necessary. ANIKA shall not be obligated to make any
changes to the Specifications or packaging of Licensed Product requested by OBI.
If the FDA requires a change to the Specifications or packaging of Licensed
Product (other than changes requested by the OBI), ANIKA shall use commercially
reasonable efforts to make such change with respect to the Licensed Product sold
in the Territory, and the costs for making such change as required by such
regulatory agency shall be born by ANIKA. OBI shall reimburse ANIKA for the
actual, documented expenses incurred by ANIKA in connection with changes to the
Specifications or the packaging of product requested by OBI, including, without
limitations, any necessary Regulatory Approval costs. Notwithstanding any other
terms of this paragraph, if the change to the Specifications or packaging of the
Licensed Product creates obsolescence in existing inventory held by ANIKA or OBI
or any other person or entity, the actual costs of such obsolescence, together
with any actual hard disposal costs, shall be the responsibility of OBI. ANIKA
shall have the right to appoint an independent certified accountant mutually
acceptable to both parties to audit and review OBI's financial records
pertaining directly to such costs for obsolescence. Any disputes arising from a
request for cost-sharing or reimbursement of expenses incurred in connection
with a change in Specifications or packaging of the Licensed Product under this
Section 6.5(a) and not resolved informally within 30 days shall be referred to
the Steering Committee for resolution. If the Steering Committee does not
resolve the matter within 60 days, either Party may submit the matter to
arbitration as provided in Article XVI.

                                       21
<Page>

        (b)     RECORDS. ANIKA shall keep complete and accurate records
pertaining to the manufacture, including quality control, of the Licensed
Product. OBI shall keep complete and accurate records pertaining to the use,
sale and other disposition of the Licensed Product, including for each lot
number of Licensed Product, the quantity shipped and where the lot was shipped.
Each party shall keep its respective records for at least five (5) years or for
such longer period if and as required by law. Each party shall make available
such records to the other party for such lawful purpose as such other party may
reasonably request in writing.

6.6.    DELIVERY.

        (a)     All charges for packing, hauling, storage, bar coding and
transportation to the Shipping Point are included in the transfer price as set
forth in Section 6.2 hereunder unless otherwise agreed to by the Parties. OBI
will pay all freight, shipping, insurance, duties, forwarding and handling
charges, taxes, storage and all other charges applicable to Licensed Product
after it is delivered by ANIKA to the Shipping Point. All shipments will be
accompanied by a packing slip which describes the articles, states the purchase
order number and shows the shipment's destination. ANIKA agrees to promptly
forward the original bill of lading or other shipping receipt for each shipment
in accordance with OBI's instructions.

        (b)     SHIPMENT. The risk of loss with respect to Licensed Product
shall remain with ANIKA through production until Licensed Product is delivered
to OBI FOB ANIKA's manufacturing facility (currently located in Woburn,
Massachusetts), or other manufacturing facility that has received Regulatory
Approval from the FDA (the "Shipping Point"). ANIKA will pack all Licensed
Product ordered hereunder in a manner suitable for shipment and sufficient to
enable the Licensed Product to withstand the normal effects of shipping,
including handling during loading and unloading. OBI is responsible for
designating the carrier(s) and negotiating terms for shipment of Licensed
Product, and is responsible for payment of all shipping insurance, handling,
storage and custom duties and fees.

        (c)     INVENTORY. ANIKA and OBI agree to reasonably cooperate to
improve the process for ordering Licensed Product with the mutual objectives of
expediting the supply process to a just-in-time process and reducing inventory
costs.

6.7.    INSPECTIONS.

        (a)     During the Term, OBI shall have the right, upon reasonable
notice to ANIKA and during regular business hours, to inspect and audit the
facilities being used by ANIKA (or any Third Party) for production and storage
of the Licensed Product to assure compliance by ANIKA (and its suppliers) with
GMP and applicable FDA rules and regulations pertaining to Licensed Product and
with other provisions of this Agreement.

        (b)     ANIKA shall have the right to visit OBI's facilities where the
Licensed Product is stored or delivered from time to time during the term of
this Agreement to perform a quality audit of OBI's records concerning storage
and distribution (including shipping and handling) of the Licensed Product. Such
visits shall be conducted during normal business hours upon at least

                                       22
<Page>

ten (10) days prior written notice and each party shall be limited to not more
than one visit per year, except in the event of a recall of the Licensed Product
or governmental action involving the Licensed Product.

6.8.    NON-CONFORMING PRODUCT.

        OBI shall evidence any claims of nonconformity of Licensed Product with
an analysis of the allegedly nonconforming Licensed Product that shall have been
prepared by OBI or its agent. Such report shall be accompanied with a copy of
the records pertaining to such testing and a sample of the Licensed Product from
the batch analyzed. If, after its own analysis of a sample stored by ANIKA from
such lot of Licensed Product (which such sample ANIKA is required to retain)
(the "Retained Sample"), ANIKA confirms such nonconformity, ANIKA shall, at
ANIKA's election, either replace the nonconforming Licensed Product with
conforming Licensed Product as soon as reasonably practicable at ANIKA's expense
or refund to OBI the entire transfer price therefore. The foregoing, and the
rights under this Section 6.8, shall be OBI's sole and exclusive remedy with
respect to such nonconformity. The nonconforming Licensed Product shall either
be returned to ANIKA, at ANIKA's request and its expense, or destroyed, at
ANIKA's expense.

        If, after ANIKA's own analysis, ANIKA does not confirm conformance to
  the Specifications or whether the Licensed Product has such a defect, either
  Party may deliver the Licensed Product to an independent Third-Party
  laboratory, mutually and reasonably acceptable to both Parties, for analytical
  testing to confirm the Licensed Product's conformance to the Specifications or
  the presence or absence of defects. All costs associated with such Third-Party
  testing shall be at OBI's expense unless the tested Licensed Product is deemed
  by such Third-Party to be materially defective or not in compliance with the
  Specifications, in which case all such costs, including reimbursement of
  freight and disposition costs, shall be promptly paid by ANIKA. No inspection
  or testing of or payment for Licensed Product by OBI or any Third-Party agent
  of OBI shall constitute acceptance by OBI thereof, nor shall any such
  inspection or testing be in lieu or substitution of any obligation of ANIKA
  for testing, inspection and quality control as provided in the Specifications
  or under applicable local, state, or federal laws, rules, regulations,
  standards, codes or statutes. In the event that any such shipment or batch
  thereof is ultimately agreed or found to meet the specifications, OBI shall
  retain such shipment or batch, and all the terms and conditions of this
  Agreement shall continue to apply to such Licensed Product.

6.9.    CORRECTIVE ACTION.

        (a)     REPORTABLE EVENTS. ANIKA shall be responsible for notifying all
applicable regulatory authorities of reportable events (including without
limitation complaints) involving the Licensed Product for which ANIKA receives
written notification, as required by applicable laws. OBI shall notify ANIKA of
potentially reportable events promptly but in no event later than twenty-four
(24) hours after the event. In addition, all such notices by OBI shall be
consistent with the requirements of law in the applicable jurisdictions.

                                       23
<Page>

        (b)     LICENSED PRODUCT COMPLAINTS. OBI shall promptly communicate to
ANIKA by facsimile, telephone or email (and confirm any such telephone
communication as instructed at the time) any complaint received from users of
the Licensed Product, in the configuration supplied by ANIKA. Each notification
of a complaint shall contain, but not be limited to, the lot number, dosage
size, expiration date, indication for actual use and description of
circumstances involved in the failure of the Unit(s) in question. Each complaint
notification will contain all the information available to OBI at that time,
including all information then available which is required in the ANIKA
Complaint Form attached hereto as Exhibit F, and a summary of the proposed
action to be taken by OBI to comply with its legal obligations. OBI will provide
additional information promptly as it becomes available. OBI acknowledges that
complaint investigation is the responsibility of ANIKA, but OBI reserves the
right to directly contact its customers.

        (c)     SAFETY OR EFFICACY CONCERNS. Each party agrees to notify the
other party as soon as practicable of any information of which it becomes aware
which relates to the safety or efficacy claims of the Licensed Product. Upon
receipt of any such information, the parties shall consult with each other in an
effort to arrive at a mutually agreeable course of action that is consistent
with the obligations of the parties under this Agreement and constant with
applicable laws.

        (d)     LICENSED PRODUCT RECALLS. If (i) the Licensed Product is
subjected to a recall by any governmental agency, or (ii) ANIKA after
notification to OBI elects to make a Licensed Product recall or (iii) in the
event either Party, after notification to, and consultation with, the other,
elects to make a Licensed Product withdrawal or corrective action, the expense
of such recall, withdrawal or corrective action shall be borne as provided
below. If (i) it is established that the Licensed Product was nonconforming
pursuant to Section 6.8 upon delivery by ANIKA to a common carrier at ANIKA's
Shipping Point, or (ii) such recall, withdrawal or corrective action arises from
any breach by ANIKA of the provisions of this Agreement, then ANIKA, subject to
Article XII, shall hold OBI harmless and shall bear all expenses related to the
recall, withdrawal or corrective action, including the replacement of the
recalled or withdrawn Licensed Product, which shall be replaced as soon as
reasonably practicable. If such recall, withdrawal or corrective action arises
as a result of actions or omissions on the part of OBI or its Affiliates,
distributors or sublicensees, or from any breach by OBI, its Affiliates,
distributors or sublicensees of the provisions of this Agreement, then OBI,
subject to Article XII, shall hold ANIKA harmless and shall bear all costs and
expenses in connection with such recall, withdrawal or corrective action. OBI
shall keep, and will use its reasonable efforts to the extent required by law to
cause its Affiliates, distributors and sublicensees to keep, detailed
distribution records for each lot number detailing the quantity shipped and the
location where the lot was shipped, so that in event of a recall, OBI will be
able to contact all physicians and/or end users.

6.10.   FAILURE TO SUPPLY: LICENSE TO MANUFACTURE.

                (i)       If ANIKA fails, for a period of three consecutive
        months, to deliver eighty percent (80%) of the aggregate cumulative
        quantity of all Licensed Products which ANIKA has agreed to deliver to
        OBI pursuant to binding purchase orders pursuant to Section 6.3(b) of
        this Agreement during that period, without being able to complete the

                                       24
<Page>

        delivery requirements along with any other scheduled delivery
        requirement in the next subsequent two months (including a failure
        caused by a force majeure) (hereinafter referred to as a "Failure to
        Supply"), then during any such License Period (as defined), OBI shall be
        permitted (with no obligation or liability to ANIKA) to obtain such
        Licensed Product from another supplier (an "Alternative Supplier"), to
        use, sell, make and have made Licensed Product pursuant to the license
        granted in this Section 6.10; provided, however, OBI shall use
        commercially reasonable efforts to ensure that the term of any agreement
        with an Alternative Supplier (the "Alternative Supplier Agreement") is
        as short as possible; provided further however, in no event shall the
        term of any Alternative Supplier Agreement extend beyond 30 months
        inclusive of any termination notice requirements under the terms of such
        Alternative Supplier Agreement. Upon the occurrence of any such Failure
        to Supply and through and until the later of such time as ANIKA fully
        resumes its supply obligations hereunder: ANIKA shall make available to
        OBI or its designee access to all Information, ANIKA Patents and ANIKA
        Know-How for OBI to procure required raw materials or product or arrange
        an alternative supplier of Licensed Product and (b) ANIKA shall provide
        reasonable advice and consultation in connection therewith and (c) ANIKA
        will not be entitled to implied royalties or compensation for lost
        profits as a result of Licensed Product obtained from such Alternative
        Supplier and (d) OBI shall bear all costs necessary to relocate
        manufacturing to an Alternative Supplier's facility in accordance with
        this Section 6.10. Notwithstanding anything to the contrary contained in
        this Agreement, in the event that OBI shall manufacture or have
        manufactured the Licensed Product, pursuant to this Section 6.10(i), (1)
        OBI shall be permitted to disclose to any Third Party any Confidential
        Information as is reasonably necessary in connection with such
        activities (subject to such Third Party agreeing in writing to be bound
        by the terms of Article VII hereof), and (2) ANIKA shall supply on
        commercially reasonable terms the Active Ingredient (as defined below)
        if requested by OBI..

                (ii)      From and after the Effective Date ANIKA will use
        commercially reasonable efforts to identify and qualify a second source
        of the hyaluronic acid active ingredient (the "Active Ingredient") in
        Licensed Products (the "Second Source Qualification"). Until such time
        as the Second Source Qualification, ANIKA will maintain a minimum
        inventory of the Active Ingredient for a 12-month period sufficient to
        manufacture Licensed Products as set forth in the Rolling Annual
        Forecast. OBI shall pay all administrative and regulatory fees in
        connection with the Second Source Qualification in an amount not to
        exceed [*****************************].

                (iii)     ANIKA hereby grants to OBI a fully paid up license,
        with the right to grant sub-licenses to its Affiliates, to manufacture
        and have manufactured Licensed Products solely in the Field and
        Territory; PROVIDED, HOWEVER, that the license granted hereunder shall
        be effective only during the period of time commencing upon the
        occurrence of a Failure to Supply and continuing through and until such
        time as ANIKA fully resumes its supply obligations hereunder (such
        period is hereinafter referred to as a "License Period") and OBI shall
        not exercise its rights to make or have made the

                                       25
<Page>

        Licensed Products pursuant to such license other than during such a
        License Period. For the avoidance of doubt, the license granted
        hereunder shall automatically be terminated upon the end of the License
        Period.

                (iv)      In the event that either OBI or ANIKA has actual
        knowledge of any facts or circumstances that are likely to result in a
        material disruption to the manufacture or sale of Licensed Products
        ("Adverse Knowledge"), such Party that has such Actual Knowledge shall
        give prompt notice to the other Party, and such Parties or the Steering
        Committee shall work together in good faith to address such Adverse
        Knowledge.

6.11.   INSURANCE.

     Each Party agrees to procure and maintain in full force and effect during
the term of this Agreement valid and collectible insurance policies in
connection with its activities as contemplated hereby which ANIKA policies shall
be in compliance with Exhibit F attached hereto. Upon the other Party's request,
each Party shall provide the other with a certificate of coverage or other
written evidence reasonably satisfactory to the requesting Party of such
insurance coverage.

6.12.   Packaging.

        OBI shall have the right to determine the appearance and text of any
labeling and packaging consistent with the approved label used in connection
with the Licensed Product in the Territory or any finished product containing or
contained in the Licensed Product in the Territory. OBI shall pay all of the
costs associated with the design of the labeling and packaging for the Licensed
Product. Once the initial labeling and packaging has been decided upon and
confirmed in writing, ANIKA shall not be required to make subsequent changes to
such labeling unless OBI agrees to pay all additional costs associated with the
implementing of changes and to pay ANIKA's out of pocket costs associated with
all packaging inventory rendered obsolete by the change in labeling.
Notwithstanding the foregoing, if any changes are required to be made to the
packaging or labeling as a result of the changes required by ANIKA, ANIKA shall
bear the expenses thereof.

6.13.   CLINICAL TRIAL SUPPLIES

        ANIKA agrees to supply up to 1000 Units of Licensed Product per clinical
trial at no cost only if, and to the extent, both the Steering Committee and
ANIKA have approved such clinical trial. For approved clinical trials requiring
more than 1000 units, ANIKA will provide Licensed Products at a price of [****]
per unit, subject to Section 6.2(b).

                                       26
<Page>

          ARTICLE VII - PUBLICATIONS; TRANSFER OF DATA; CONFIDENTIALITY

7.1.    CONFIDENTIALITY; EXCEPTIONS.

        The Parties acknowledge that discussions between ANIKA and OBI will
necessarily require the exchange of information (including detailed financial
and product information) that is considered confidential and proprietary by the
disclosing Party. The Parties agree that any information relating to the
business of the disclosing Party which such Party discloses to the other Party
pursuant to this Agreement shall be considered "Confidential Information" and
shall include, without limitation, (i) the ANIKA Know-How; (ii) earnings, costs,
and other financial information; (iii) drawings, formulations, samples,
technical data, photographs, specifications, manufacturing methods, testing
procedures; (iv) marketing, sales and customer information relating to the
disclosing Party's business; (v) all clinical studies and data developed by
either party in connection with this Agreement; and (vi) all other Information
related to Licensed Product in the Field. Except to the extent expressly
authorized by this Agreement or otherwise agreed in writing, the Parties agree
that, for the time royalties are due and for five (5) years thereafter, subject
to and except as permitted by Section 7.4 of this Agreement, each Party shall
keep confidential (and shall cause the directors, officers, employees and agents
of such Party or its Affiliates and sublicensors and distributors) to keep
completely confidential and shall not publish or otherwise disclose or use for
any purpose other than as provided for in this Agreement the Confidential
Information, except to the extent the receiving Party's (and their Affiliates)
employees and/or agents (including consultants) need to know such Confidential
Information in order to discharge such Party's obligations and exercise its
rights hereunder. Each Party will protect the other Party's Confidential
Information from unauthorized use, access or disclosure in the same manner that
it protests it own similar Confidential Information. Confidential Information
shall not include information which:

                (i)       was in the lawful knowledge and possession of the
        receiving Party prior to the time it was disclosed to, or learned by,
        the receiving Party, or was otherwise developed independently by the
        receiving Party, as evidenced by written records kept in the ordinary
        course of business, or other documentary proof of actual use by the
        receiving Party;

                (ii)      was generally available to the public or otherwise
        part of the public domain at the time of its disclosure to the receiving
        Party;

                (iii)     became generally available to the public or otherwise
        part of the public domain after its disclosure and other than through
        any act or omission of the receiving Party in breach of this Agreement;

                (iv)      was disclosed to the receiving Party, other than under
        an obligation of confidentiality, by a Third Party who had no obligation
        to the disclosing Party not to disclose such information to others; or

                                       27
<Page>

                (v)       was or is required to be disclosed as a result of a
        judicial order or decree or applicable law or regulation; provided,
        however, that the Party whose Confidential Information is the subject of
        such judicial order or decree is given the opportunity (to the extent
        not violative of applicable law) to contest the judicial order or decree
        prior to any disclosure.

        Each Party will be responsible and liable for all breaches of the
confidentiality provisions of this Agreement by its directors, officers,
employees, agents and Affiliates, and shall indemnify the other for any breaches
thereof.

7.2.    AUTHORIZED DISCLOSURE.

        Except as expressly provided otherwise in this Agreement, each Party may
disclose Confidential Information as follows: To Third Parties (including
without limitation investors and potential investors of ANIKA, Affiliates,
sublicensees, distributors and suppliers of ANIKA and Affiliates of OBI) under
appropriate terms and conditions that include confidentiality provisions
substantially equivalent to those in this Agreement as is reasonably necessary
to exercise the rights granted herein.

7.3.    PUBLICATIONS.

        Notwithstanding any other provision of this Agreement, including, but
not limited to the provisions of Section 7.4, ANIKA may not publish the results
of any of OBI's Development activities relating to Licensed Products in the
Field without the prior written consent of OBI. ANIKA may publish without the
prior written consent of OBI results of its Development activities relating to
Licensed Products for use outside the Territory.

7.4.    PUBLIC ANNOUNCEMENTS.

        Neither Party shall originate any publicity, press release or public
announcements, written or oral, whether to the public or press, relating to this
Agreement, including its existence, the subject matter to which it relates,
performance under it or any of its terms, to any amendment hereto or
performances hereunder without the prior written consent of the other Party (not
to be unreasonably withheld), save only such announcements that are required by
applicable law or any securities exchange or Nasdaq to be made or that are
otherwise agreed by the Parties.

        In the event of such publication, press release or public announcement
(other than those required by applicable law or any securities exchange or
Nasdaq), the Party making the announcement will give the other Party at least
reasonable advance notice, where possible, of the text of the announcement so
that the other Party will have an opportunity to comment upon the announcement.
Notwithstanding anything contained in this Agreement to the contrary, (i) upon
execution of this Agreement, ANIKA may issue a press release in the form of
Exhibit C, and (ii) OBI acknowledges that ANIKA is permitted to file this
Agreement with the Securities and Exchange Commission.

                                       28
<Page>

        Notwithstanding the foregoing, however, where urgent, unusual and rare
circumstances require immediate disclosure in the opinion of the Party's
counsel, the Party will, unless impossible because of legal reasons, provide at
least one (1) Business Day's advance written notice.


       ARTICLE VIII - OWNERSHIP OF INTELLECTUAL PROPERTY AND PATENT RIGHTS

8.1.    TITLE.

        Title to all Patents claiming inventions made solely by an employee of a
Party in the course of performing Development ("Development Invention") shall be
owned by such Party. Title to Patents claiming inventions made jointly by
employees of OBI and ANIKA shall be jointly owned by OBI and ANIKA. The laws of
the United States with respect to joint ownership of inventions shall apply in
all jurisdictions; accordingly, except as expressly provided in this Agreement,
neither Party shall have any obligation to account to the other for profits, or
to obtain any approval of the other party to license a jointly-owned patent, by
reason of joint ownership thereof.

8.2.    LICENSE TO OBI DEVELOPMENT INVENTIONS.

        OBI hereby grants ANIKA and its Affiliates a perpetual, royalty-free,
fully paid-up, exclusive, worldwide license to use the OBI Development
Inventions, with the right to sublicense, to use, manufacture, have
manufactured, sell, offer for sale, import, have imported, offer to import,
Licensed Products outside the Territory for a cost equal to half of OBI's fully
allocated direct Development costs associated with any such OBI Development
Invention used by ANIKA.

8.3.    DISCLOSURE OF PATENTABLE INVENTIONS.

        Each Party shall provide to the other any invention disclosure submitted
in the normal course of disclosing an invention arising in the course of the
Development or relating to Licensed Product. Such invention disclosures shall be
provided to the other Party promptly after creation.

8.4.    PATENT FILINGS.

        (a)     Each Party may prepare, file, prosecute and maintain Patents to
cover discoveries and inventions made solely by its own employees or consultants
relating to any Licensed Products being developed or sold hereunder by OBI and
use reasonable efforts to file initially all such applications in the United
States. Inventions relating to the discovery, evaluation, manufacture, use or
sale of Licensed Products that are made jointly by OBI and ANIKA in the course
of this Agreement (hereinafter referred to as "Joint Patents") may be filed,
prosecuted and maintained by ANIKA. The determination of the countries in which
to file Joint Patents shall be made by ANIKA, provided, however, ANIKA agrees to
file in the United States and Mexico. ANIKA shall have the right to direct or
control all material actions relating to the prosecution or maintenance of Joint
Patents.

                                       29
<Page>

        (b)     The Party who is responsible for filing a Patent, will be termed
the "Filing Party". In the case of a solely owned invention the Filing Party
shall bear all Patent Cost associated therewith. With respect to a joint patent
each of the Parties shall bear one half of all Patent Cost associated therewith.
The filing Party shall keep the other Party apprised of the status of each Joint
Patent, and shall seek the advice of the other Party with respect to patent
strategy and drafting applications and shall give reasonable consideration to
any suggestions or recommendations of the other Party concerning the
preparation, filing, prosecution, maintenance and defense thereof. The Parties
shall cooperate reasonably in the prosecution of all Joint Patents and shall
share all material information relating thereto, including all material
communications from patent offices, promptly after receipt of such information.
If, during the term of this Agreement, the filing Party intends to allow any
Joint Patent to lapse or leave abandoned, the filing Party shall, whenever
practicable, notify the non-filing Party of such intention at least sixty (60)
business days prior to the date upon which such Patent shall lapse or become
abandoned, and the non-filing Party shall thereupon have the right, but not the
obligation, to assume responsibility for the prosecution, maintenance and
defense thereof and all expenses related thereto.

8.5.    INFRINGEMENT BY THIRD PARTIES.

                (i)       If any ANIKA, OBI or Joint Patent covering a Licensed
        Product is infringed by a Third Party in any country in connection with
        the manufacture, use and sale of a Licensed Product in such country, the
        Party to this Agreement first having knowledge of such infringement
        shall promptly notify the other in writing. The notice shall set forth
        the known facts of that infringement in reasonable detail.

                (ii)      ANIKA shall have the primary right, but not the
        obligation, to institute, prosecute, and control any action or
        proceeding with respect to such infringement of the Joint Patent, by
        counsel of its own choice, and at its own expense. If ANIKA fails to
        bring an action or proceeding within a period of one hundred eighty
        (180) days after a request by OBI to do so, OBI shall have the right to
        bring and control any such action by counsel of its own choice, and at
        its own expense.

                (iii)     The Party bringing suit under this Paragraph 8.5
        regarding a Joint Patent shall bear all costs and expenses of the suit,
        with any damages or other monetary awards recovered being split with 70%
        to OBI and 30% to ANIKA after costs of the prosecuting Party are
        reimbursed..

                (iv)      A settlement or consent judgment or other voluntary
        final disposition of a suit brought by a Party related to a joint patent
        under this Paragraph 8.5 may be entered into without the consent of the
        other Party; provided that such settlement, consent judgment or other
        disposition does not admit the invalidity or unenforceability of any
        Joint Patent; and provided further that any rights to continue the
        infringing activity in such settlement, consent judgment or other
        disposition shall be limited to the product or activity that was the
        subject of the suit.

                                       30
<Page>

                (v)       Each Party shall have the sole and exclusive right,
        but no obligation, to enforce any Patent that it solely owns against
        infringement or alleged infringement thereof by a Third Party.

8.6.    VALIDITY CHALLENGE CLAIMS.

                (i)       In the event that any person shall assert any claim
        that any of ANIKA, OBI or Joint Patents are invalid or unenforceable, or
        seeks to limit the scope of enforcement thereof (each a "Validity
        Challenge Claim"), whether in defense against an enforcement action
        brought by a party, by a separate action for declaratory judgment, or
        otherwise, the party receiving notice of such claim shall promptly
        notify the other party.

                (ii)      ANIKA shall have the primary right, but not the
        obligation, to institute, prosecute, and control any action or
        proceeding with respect to any Validity Challenge Claim relating to a
        Joint Patent, by counsel of its own choice, and at its own expense. If
        ANIKA fails to bring an action or proceeding within a period of one
        hundred eighty (180) days after a request by OBI to do so, OBI shall
        have the right to bring and control any such action by counsel of its
        own choice, and at its own expense.

                (iii)     The Party bringing suit under this Paragraph 8.6
        regarding a Joint Patent shall bear all costs and expenses of the suit,
        with any damages or other monetary awards recovered being split with 70%
        to OBI and 30% to ANIKA after costs of the prosecuting Party are
        reimbursed. The other party will reasonably cooperate with and use
        commercially reasonable efforts to assist the Party bringing suit under
        this Paragraph 8.6, and the Party bringing such suit shall reimburse the
        other Party for its out-of-pocket expenses incurred as a result of such
        cooperation.

                (iv)      A settlement or consent judgment or other voluntary
        final disposition of a suit brought by a Party relating to a Joint
        Patent under this Paragraph 8.6 may be entered into without the consent
        of the other Party; provided that such settlement, consent judgment or
        other disposition does not admit the invalidity or unenforceability of
        any Joint Patent.

                (v)       Each Party shall have the sole and exclusive right,
        but no obligation, to institute, prosecute and control any action or
        proceeding with respect to any Validity Challenge Claim relating to any
        Patent that it solely owns.

8.7.    PATENT ASSIGNMENT.

        Neither Party may assign, license or otherwise transfer its rights under
any Joint Patent except with the prior written consent of the other Party;
provided, however, that either Party may assign such rights without consent to
permitted assignee under this Agreement in connection with a merger or similar
reorganization or the sale of all or substantially all of its assets.

                                       31
<Page>

8.8.    NOTICES RELATING TO THE ACT.

        ANIKA shall notify OBI of (a) the issuance of each U.S. and Mexican
Patent included among the ANIKA Patents, giving the date of issue and patent
number for each such patent.

8.9.    DEFENSE AND SETTLEMENT OF THIRD PARTY CLAIMS

        If a Third Party asserts that a patent right owned by it is infringed by
the use or sale of Licensed Product, OBI will be solely responsible for
defending against any such assertions at its cost and expense. OBI shall have
the right to defend and settle against such charge of infringement. ANIKA shall
have the same responsibility and rights in such Third Party actions if the
alleged infringement relates to the manufacture of Licensed Product. If an
action has not been brought but an assertion has been made that a patent right
owned by a Third Party is infringed by the use or sale of Licensed Product, then
the parties shall first exercise their rights and/or perform their obligations
set forth in Section 5.4. If an action for patent infringement is brought
against OBI for the use or sale of Licensed Product by a Third Party, OBI shall
promptly notify ANIKA. ANIKA shall have the right, but not the obligation, to
settle the litigation at its sole cost and expense. In no event, however, shall
any such settlement by ANIKA modify the rights and licenses granted hereunder to
OBI. If OBI is defending such charge of infringement, OBI shall have the right
to apply up to 50% of the royalties due ANIKA on sales of the allegedly
infringing Licensed Product against its litigation expenses during the pendency
of any litigation, but only in the event that the infringement action is not
based on or not related to a Modified Licensed Product. "Modified Licensed
Product" means Licensed Product not in the Currently Filed PMA (except that
Modified Licensed Product shall not include Licensed Products which result
solely from changes initiated by ANIKA). If, as a result of judgment in the
litigation or settlement with the Third Party not in connection with or not
related to a Modified Licensed Product, OBI is required to pay royalties or
other monies to such Third Party, OBI may thereafter deduct from the royalties
due ANIKA on net sales of the Licensed Product charge to infringe, an amount of
which is the lesser of 50% of all sums actually paid by OBI to such Third Party
or 50% of all royalty payments otherwise payable to ANIKA on the net sales of
such Licensed Product. In the case of a litigation involving a Modified Licensed
Product, OBI shall be fully responsible for all costs and expenses of such
litigation or settlement thereof.


                  ARTICLE IX - REPRESENTATIONS AND WARRANTIES.

9.1.    REPRESENTATIONS AND WARRANTIES OF ANIKA.

        ANIKA hereby represents and warrants to OBI as follows:

        (a)     ANIKA is a corporation duly organized, validly existing and in
good standing under the laws of the Commonwealth of Massachusetts and has all
requisite corporate power and lawful authority to own, lease and operate its
assets and to carry on its business as heretofore conducted. ANIKA has the full
legal right, corporate power and authority to execute and deliver this Agreement
and the other agreements contemplated hereby and to consummate the

                                       32
<Page>

transactions contemplated hereby and thereby. This Agreement has been duly
executed and delivered by ANIKA and constitutes the valid and binding obligation
of ANIKA, enforceable against ANIKA in accordance with its terms, except as such
enforceability may be limited by bankruptcy, insolvency, reorganization or
similar laws affecting creditors' rights generally or by general equitable
principles.

        (b)     ANIKA owns all rights, title and interest in the Licensed
Product necessary to grant the rights contained in this Agreement to OBI for
Licensed Product in the Territory. The Licensed Product does not infringe upon
any proprietary right, other than patents of any Person in the Territory;
provided, however, that ANIKA makes no such representation and warranty with
respect to any trademarks or trade dress not licensed to OBI hereunder which may
be used by OBI in the marketing, distribution and sale of the Licensed Product.
ANIKA does not have actual knowledge of any infringement by the Licensed Product
of any issued United States or Mexican patent; however, ANIKA makes no
representations or warranties regarding patents in any foreign jurisdictions
other than Mexico. ANIKA makes no representation or warranty with respect to any
marketing, distribution sale or use of the Licensed Product not in accordance
with any applicable PMA or any other Regulatory Approval. Nothing contained in
this Agreement is in conflict with any other agreement to which ANIKA is a Party
or is otherwise bound. ANIKA has not granted the right to market, sell or
distribute the Licensed Product in the Field in the Territory to any other
Person.

        (c)     ANIKA represents and warrants to OBI that at the time of
delivery to a common carrier at ANIKA's Shipping Point, all Licensed Product
supplied in connection with this Agreement shall be of merchantable quality, fit
for the purpose intended by this Agreement and free from defects in material and
workmanship and shall be manufactured and provided in accordance and conformity
with the Specifications and in compliance with this Agreement. ANIKA represents
and warrants that it shall materially comply with all pertinent present and
future statutes, laws, ordinances and regulations relating to the manufacture
and supply of the Licensed Product in the Territory and in the Field being
provided hereunder, including, without limitation, those enforced by the United
States Food and Drug Administration (including compliance with GMP) and
International Standards Organization Rules 9000 et seq.

        (d)     ANIKA'S WARRANTIES SET FORTH IN THIS AGREEMENT ARE IN LIEU OF
ANY OTHER WARRANTY, WHETHER EXPRESS OR IMPLIED, WRITTEN OR ORAL, AND, ANIKA
HEREBY DISCLAIMS ALL IMPLIED WARRANTIES, INCLUDING ANY IMPLIED WARRANTY OF
MERCHANTABILITY, NON-INFRINGEMENT, TITLE OR FITNESS FOR A PARTICULAR PURPOSE.

        (e)     EXCEPT AS OTHERWISE EXPRESSLY PROVIDED FOR IN THIS AGREEMENT,
NEITHER PARTY SHALL IN ANY EVENT BE LIABLE TO THE OTHER FOR PUNITIVE,
INCIDENTAL, SPECIAL OR CONSEQUENTIAL DAMAGES ARISING OUT OF THIS AGREEMENT,
INCLUDING BUT NOT LIMITED TO LOSS OF PROFITS.

                                       33
<Page>

9.2.    REPRESENTATIONS AND WARRANTEES OF OBI.

        OBI hereby represents and warrants to ANIKA as follows:

        (a)     OBI is a limited partnership duly organized, validly existing
and in good standing under the laws of the State of New Jersey and has all
requisite power and lawful authority to own, lease and operate its assets and to
carry on its business as heretofore conducted. OBI is a wholly-owned indirect
subsidiary of Johnson & Johnson. OBI has the full legal right, power and
authority to execute and deliver this Agreement and the other agreements
contemplated hereby and to consummate the transactions contemplated hereby and
thereby. This Agreement has been duly executed and delivered by OBI and
constitutes the valid and binding obligation of OBI, enforceable against OBI in
accordance with its terms, except as such enforceability may be limited by
bankruptcy, insolvency, reorganization or similar laws affecting creditors'
rights generally or by general equitable principles.

        (b)     Nothing contained in this Agreement is in conflict with any
other agreement to which OBI or its Affiliates or sub-distributors is or may
become a party or is otherwise bound.

        (c)     OBI and its Affiliates and sub-distributors shall store,
distribute, market and sell Licensed Product in accordance with directions for
storage and use as indicated in this Agreement and any amendments hereto.

        (d)     OBI and its Affiliates and sub-distributors shall distribute,
market and sell Product in accordance with all applicable international,
national and local laws of each country within the Territory, including without
limitation, applicable drug and medical device laws.


              ARTICLE X - ANIKA'S GENERAL OBLIGATIONS AND COVENANTS

        (a)     During the Term of this Agreement, ANIKA shall, in accordance
with any marketing plan, strategy and direction approved by the Steering
Committee:

                (i)       Provide to OBI reasonable technical, scientific, sales
        and marketing support with respect to the Licensed Product, to the
        extent OBI makes available opportunities to provide such support;

                (ii)      Use commercially reasonable efforts to ensure that
        products manufactured by the ANIKA for the purposes other than the
        treatment of osteoarthritis (other than the Licensed Product) are not
        marketed or used in the Field in the Territory (the "Gray Market
        Product"). If OBI reasonably believes that Gray Market Product is being
        marketed or used in any country in the Territory, and has caused
        financial loss to OBI of at least [****], OBI shall promptly notify
        ANIKA of such belief, and provide ANIKA with a written description of
        the basis for OBI's belief. Within five (5) Business Days of ANIKA's
        receipt of such notice, the matter shall be submitted to the Steering
        Committee for resolution of the following issues: (A) whether or not the
        goods believed by OBI to be Gray Market Product are actually goods
        manufactured by ANIKA; (B) whether or not

                                       34
<Page>

        the goods believed by OBI to be Gray Market Product are actually being
        marketed or used in the Field in the Territory; (C) upon determination
        that the goods are in fact Gray Market Product, whether or not the
        financial loss to OBI is at least [******], and if so, the approximate
        amount; and (D) upon determination that Gray Market Product has caused
        financial loss to OBI of at least [*****], what commercially reasonable
        course of action ANIKA shall be required to take, including without
        limitation taking such action, including legal and/or equitable action
        as required to prevent the Gray Market Product from entering the
        Territory and to prevent it from being marketed or used therein. In the
        event the Steering Committee does not reach a resolution concerning the
        Gray Market Product within thirty (30) days after such issues are
        presented to it, either Party may submit the matter to arbitration as
        provided in Article XVI herein, for resolution of the same issues as
        outlined in clauses (A) through (C) in the immediately preceding
        sentence;

                (iii)     Use commercially reasonable efforts to ensure that
        products manufactured by ANIKA for the purposes of treatment of
        osteoarthritis outside of the Territory (including the Licensed Product)
        are not marketed or used in the United States of America (the "Diverted
        Product"). If OBI reasonably believes that Diverted Product is being
        marketed or used in the United States of America, and has caused
        financial loss to OBI of at least [*****], OBI shall promptly notify
        ANIKA of such belief, and provide ANIKA with a written description of
        the basis for OBI's belief. Within five (5) Business Days of ANIKA's
        receipt of such notice, the matter shall be submitted to the Steering
        Committee for resolution of the following issues: (A) whether or not the
        goods believed by OBI to be Diverted Product are actually goods
        manufactured by ANIKA (B) whether or not the goods believed by OBI to be
        Diverted Product are actually being marketed or used in the Field in the
        United States of America; (C) upon determination that the goods are in
        fact Diverted Product, whether or not the financial loss to OBI is at
        least [******], and if so, the approximate amount; and (D) upon
        determination that Diverted Product has caused financial loss to OBI of
        at least [*****], what commercially reasonable course of action ANIKA
        shall be required to take, including without limitation, taking such
        action, including legal and/or equitable action as required to prevent
        the Diverted Product from entering the United States of America and to
        prevent it from being marketed or used therein (including, without
        limitation, terminating the supply agreement(s), if permitted
        thereunder, with the parties to whom ANIKA had originally sold such
        Diverted Product). In the event the Steering Committee does not reach a
        resolution concerning the Diverted Product within thirty (30) days after
        such issues are presented to it, either Party may submit the matter to
        arbitration as provided in Article XVI herein, for resolution of the
        same issues as outlined in clauses (A) through (C) in the immediately
        preceding sentence;

                (iv)      Except as otherwise explicitly provided for herein,
        maintain ownership of all Licensed Product Regulatory Approvals and be
        responsible for making all regulatory filings for the Licensed Product
        within the Territory;

                (v)       No earlier than thirty (30) days after the execution
        and delivery of this Agreement, upon OBI's request, ANIKA shall deliver
        to OBI copies of all Information in ANIKA's possession related to
        ANIKA's Know-How and ANIKA's Patents available as

                                       35
<Page>

        of such date which ANIKA and OBI reasonably determine is relevant to the
        safety, efficacy, regulatory status, sale, marketing or distribution of
        a Licensed Product in the Territory; provided, however, that all such
        transferred Information shall be subject to the confidentiality
        provisions of Article VII of this Agreement; and

                (vi)      ANIKA agrees that it will not use or grant rights to a
        Third Party to use the Trademark in connection with any product intended
        for use in animals other than humans.


                     ARTICLE XI - OBI's GENERAL OBLIGATIONS

        During the Term of this Agreement, OBI shall:

        (a)     Store and distribute Licensed Product in accordance with
direction for storage and use as indicated in the applicable PMA and Regulatory
Approvals which are in effect at the time of such storage and use;

        (b)     Market and sell Licensed Product in accordance with approved
labeling for Licensed Product at the time of such distribution, marketing or
sales;

        (c)     Use its commercially reasonable efforts to commercialize
Licensed Product in the Territory in a manner consistent with the efforts that
OBI uses in commercializing its own pharmaceutical products;

        (d)     Subject to Article IV, notify ANIKA prior to engaging any
distributor(s) to market, sell or distribute Licensed Product in the Territory
and cause any such distributor(s) to agree in writing to be bound by the terms
of this Agreement as if OBI hereunder. Notwithstanding the foregoing, OBI shall
remain solely and primarily responsible under this Agreement.

        (e)     Be responsible for the entire cost of selling, marketing,
advertising, promoting and distributing Licensed Product in the Territory;

        (f)     Supply ANIKA with any information as required by the FDA or
other governmental agencies for U.S. and international regulatory filings
related to the sale of the Licensed Product in the Territory;

        (g)     Timely advise ANIKA in writing of any suit, claim or complaint
known to OBI resulting from the distribution or use of any Licensed Product;

        (h)     Refrain from soliciting orders from or selling Licensed Products
to any Person located outside the Territory or to any Person inside the
Territory for sales which OBI knows are intended to be distributed to users
outside the Territory;

                                       36
<Page>

        (i)     Neither acquire directly or indirectly through its Affiliates
from any Third Party, any products containing HA as the sole active ingredient
for use in the Field (a "Competing Product"), nor distribute such Competing
Product;

        (j)     Furnish to ANIKA all advertising, marketing and promotional
materials related to the Licensed Product, for review and approval as to their
conformance with regulatory requirements, not to be unreasonably withheld, at
least five (5) days prior to utilizing such materials, including, without
limitation, any content to be displayed on the website pursuant to Section 3.3
of this Agreement; provided, however, that if there is an unresolved dispute as
to whether ANIKA has unreasonably withheld approval of such materials, such
matter shall be submitted to arbitration as provided in Article XVI; provided
further, however, that should ANIKA fail to respond to any request for approval
within the applicable five (5) day period then such approval will be deemed to
have been granted;

        (k)     Invoice Third Parties (and ensure any distributors invoice Third
Parties appropriately, consistently and on a timely basis with respect to sales
of any and all Licensed Products; and

        (l)     OBI, and its Affiliates, sublicensees and distributors will, to
the extent required by applicable law, keep detailed distribution records for
each lot number detailing the quantity shipped and the first location where the
lot was shipped by OBI, and will provide ANIKA with reasonable access to records
for purposes of conducting quality control audits as provided in Section 5.6(d).
ANIKA will generate and promptly transfer to OBI the same detailed distribution
records for any and all units of the Licensed Product drop-shipped directly from
ANIKA to a customer of OBI.


                       ARTICLE XII - TERM AND TERMINATION

12.1.   TERM.

        This Agreement shall commence on the Effective Date and shall remain in
effect for ten (10) years subject to the termination provisions set forth
herein. OBI shall have the right, but not the obligation, to choose to extend
the term of this Agreement for additional periods of (5) five-year intervals
subject to the termination provisions set forth herein, so long as notification
of any five-year extension of the Term is provided by OBI to ANIKA at least
one-year prior to the expiration of the original ten (10) year Term or the
then-current five (5) year Term, as the case may be, and at such time of
notification extensions are permitted for the next five-year period only. Absent
a provision to the contrary, any extension of this Agreement shall be subject to
the terms set forth hereunder.

12.2.   TERMINATION RIGHTS.

        (a)     Notwithstanding any of the foregoing, this Agreement may be
terminated by either Party upon written notice to the other party, upon the
occurrence of any of the following: (i) a material breach of any term or
condition of this Agreement by the other Party which is amenable

                                       37
<Page>

to cure, and the breaching party shall have failed to cure such breach within
ninety (90) days from the receipt by it of written notice thereof from the other
Party; (ii) either Party commits a material breach which is not amenable to
cure; (iii) the other Party (or, in the case of OBI, its general partner or
ultimate parent Affiliate) shall commence any case, proceeding or other action
(A) under any applicable law relating to bankruptcy, insolvency, reorganization
or relief of debtors, seeking to have an order for relief entered with respect
to it, or seeking to adjudicate it as bankrupt or insolvent, or seeking
reorganization, arrangement, adjustment, wind-up, liquidation, dissolution,
composition or other relief with respect to it or its debts, or (B) seeking
appointment of a receiver, trustee, custodian or other similar official for it
or for all or any substantial part of its assets; (iv) there shall be commenced
against the other Party (or, in the case of OBI, its general partner or ultimate
parent Affiliate) any such case, proceeding or other action referred to in
clause (iii) of this Section 12.2 which results in the entry of an order for
relief; (v) the other Party (or, in the case of OBI, its general partner or
ultimate parent Affiliate) shall take any action authorizing, or in furtherance
of, or indicating its consent to, approval of, or acquiescence in, any of the
acts set forth above in clauses (iii) or (iv) of this Section 12.2; or (vi) the
other Party (or, in the case of OBI, its general partner or ultimate parent
Affiliate) shall admit in writing its inability to pay its debts as they become
due; PROVIDED, HOWEVER, that OBI may not terminate under Section 12.2(iii)-(vi)
if ANIKA has not materially breached Section 6.1 of this Agreement.

12.3.   RESULTS OF TERMINATION.

        In the event of termination of this Agreement by ANIKA, except as
expressly provided in this Article 12, all the rights and obligations, including
without limitation, the licenses granted to OBI in Article II and Article V
hereof, shall immediately terminate. Upon termination by either Party, OBI shall
provide ANIKA at no cost to ANIKA copies of all relevant communications and
correspondence with and from regulatory agencies pertaining to Licensed Products
and copies of all relevant marketing and promotional materials including
customer lists, together with all Information relating to OBI's product
development pursuant to Article II hereof. Except as otherwise provided in this
Section 12.3, upon the termination of this Agreement, each Party shall promptly:
(i) upon request return to the requesting Party all of the requesting Party's
relevant records, materials and Confidential Information relating to the
Licensed Product in the possession or control of the other Party, or its
Affiliates, suppliers or Third Party distributors or sublicensees, and (ii)
discontinue all distribution of the Licensed Product and the use of know-how in
connection therewith. Notwithstanding anything herein to the contrary, upon
termination of this Agreement for any reason, OBI shall have the right for one
(1) year to dispose of all Licensed Product then in OBI's, OBI's Affiliate's, or
Third Party distributor's possession, and the payments pursuant to Sections 5.2
and 5.3 shall be paid to ANIKA with respect to such Licensed Product as though
this Agreement had not terminated. Termination of this Agreement shall not
terminate OBI's obligation to pay ANIKA for Licensed Product which has been
shipped to OBI under this Agreement or under the supply provisions if it is sold
to a Third Party, including, without limitation, any applicable payments under
Article V hereof. Subject to the provisions of this Section 12.3 with respect to
OBI's right to dispose of Licensed Product post-termination of this Agreement,
ANIKA shall have the right upon termination of this Agreement to purchase all of
OBI' s unsold inventory in merchantable condition or having a remaining shelf

                                       38
<Page>

life acceptable to ANIKA, at the price of [****] per Unit.

12.4.   TERMINATION BY OBI.

        OBI shall have the right to terminate this Agreement as follows:

                (i)       at any time after March 31, 2004, upon 30 days prior
        written notice, if the Currently Filed PMA is not approved;

                (ii)      upon thirty (30) days written notice to ANIKA at any
        time during the Term if material data regarding the safety of the
        Licensed Product arise after the Effective Date that indicate a
        materially and adversely different safety profile as compared to the
        profile as of the Effective Date;

                (iii)     during the period from the Effective Date to the
        second anniversary of the Effective Date, OBI may not terminate other
        than pursuant to Section 12.4(i)-(iii);

                (iv)      upon two hundred and seventy (270) days written notice
        to ANIKA if such notice to terminate is given after two (2) years from
        the Effective Date; and

                (v)       upon one hundred and eighty (180) days written notice
        to ANIKA if such notice to terminate is given after three (3) years from
        the Effective Date.

        In the event of a termination under this Section 12.4, ANIKA shall
retain all payments made by OBI under this Agreement and all payments made by
OBI to purchase Licensed Product prior to the termination date, and OBI shall
also make any such payments to which ANIKA is then entitled under this Agreement
but payment of which have not previously been made by OBI. In addition, ANIKA
shall have no right to use OBI owned trademarks even if such were used by OBI in
connection with the Licensed Product.

        Article VII and any relevant definitions in Article I shall survive the
expiration and any termination of this Agreement for any reason.

12.5.   ACCRUED RIGHTS, SURVIVING OBLIGATIONS.

        Termination of the Agreement for any reason shall be without prejudice
to any Party's obligations which shall have accrued prior to such termination,
including, without limitation, the payment obligations under Article V hereof or
to the remedy, in accordance with the terms herein, of either Party hereto in
respect of any previous breach on any covenant contained herein. Such
termination shall not relieve either Party from obligations that are expressly
indicated to survive termination or expiration of the Agreement.

12.6.   TERMINATION NOT SOLE REMEDY.

        Termination is not the sole remedy under this Agreement and, whether or
not termination is effected, all other remedies will remain available except as
agreed to otherwise herein.

                                       39
<Page>

                         ARTICLE XIII - INDEMNIFICATION

13.1.   ANIKA shall indemnify, defend and hold harmless OBI, and any Affiliates
of OBI, together with their respective officers and directors, from and against
any and all losses (except consequential losses, such as, for example, loss of
business profits) including compensatory losses for personal injury, damages,
liabilities, costs and expenses, including without limitation reasonable
attorney's fees, arising out of or in connection with:

        (a)     the breach of any of ANIKA's representations and warranties made
in Section 9.1;

        (b)     the breach by ANIKA of any of its obligations, covenants or
undertakings hereunder;

        (c)     any Licensed Product recall for which ANIKA is required to bear
all costs and expenses pursuant to Section 6.9(d); and

        (d)     any act or omission of ANIKA in connection with the design,
development, manufacture, packaging, testing, warehousing or handling of the
Licensed Product;

        (e)     any infringement or alleged infringement of a Third Party's
patent rights resulting solely from the manufacture of any Licensed Product
other than Modified Licensed Products.

13.2.   OBI shall indemnify, defend and hold harmless ANIKA and any Affiliates
of ANIKA, together with their respective officers and directors, from and
against any and all losses (except consequential losses, such as, for example,
loss of business or of profits) including compensatory losses for personal
injury, damages, liabilities, costs and expenses, including without limitation
reasonable attorney's fees, arising out of or in connection with:

        (a)     the breach of any of OBI's representations and warranties made
hereunder;

        (b)     the breach by OBI of any of its obligations, covenants or
undertakings hereunder;

        (c)     any claim made by OBI, its distributors, sublicensees or
Affiliates, as to the safety or effectiveness of the Licensed Product or the use
to be made of the Licensed Product by any purchaser of Licensed Product,
contained in any advertising or other promotional material created and
disseminated by OBI, its distributors, sublicensees or Affiliates, to the extent
that such claim (A) is not supported by the Licensed Product label and package
insert as approved by the FDA (or, in Mexico, the appropriate governmental body
having authority to approve the Licensed Product, label, and package insert for
marketing in Mexico) and (B) was not approved in advance by ANIKA;

        (d)     any other act or omission of the OBI, its distributors,
sublicensees or Affiliates, in connection with the marketing, promotion, and
sale of Licensed Product, including the storage, handling and distribution by
OBI, its distributors, sublicensees or Affiliates of the Product, other than as
contemplated by this Agreement or the provisions of the PMA;

                                       40
<Page>

        (e)     any product recall for which OBI is required to bear all costs
and expenses pursuant to Section 6.9(d); and

        (f)     OBI's, its Affiliates', distributors' or sublicensees' use, sale
or disposition of Licensed Products where such Licensed Products incorporate
changes made by OBI, its Affiliates, distributors, or sublicensees, to the
Specifications or packaging which ANIKA has not approved, or changes made by
OBI, its Affiliates, distributors or sublicensees to any Regulatory Application
with respect to Licensed Product which ANIKA has not approved.

13.3.   The Parties agree that in the event of a loss for which it is determined
under this Article XIII that both Parties bear a measure of responsibility, it
is the intent of both Parties that the liability for the loss (including without
limitation all damages, hard costs and expenses, together with reasonable
attorney's fees) be apportioned among the Parties according to their respective
measures of responsibility, as that responsibility is determined according to
this Section 13.3. The Parties further agree that any portion of the loss not
attributable to either party under this Section 13.3 (and not otherwise
recoverable from a third party or its insurer) shall be borne equally among the
Parties. For example, the Party determined to be 10% responsible under Article
XIII pays 10% of the loss, the Party determined to be 60% responsible pays 60%
of the loss, and each Party pays one-half of the remaining 30%. Within ten (10)
business days after either Party so requests, the Steering Committee shall
convene to develop an equitable apportionment of liability for the loss
according to this Article XIII. If the Steering Committee fails to agree on an
apportionment within twenty (20) days after meeting, either Party may submit the
matter to arbitration under this Article XIV.

13.4.   Notwithstanding anything contained in this Agreement to the contrary,
the Parties expressly agree that ANIKA shall have no liability to OBI under this
Article XIII for claims, losses, or liability of any kind based upon or related
to:

        (a)     OBI's, its Affiliates', distributors', sublicensees' use, sale
or disposition of Licensed Products where such Licensed Products incorporates
changes made by OBI, its Affiliates, distributors or sublicensees to the
Specifications or packaging which ANIKA has not approved, or changes made by
OBI, its Affiliates, distributors or sublicensees, to any Regulatory
Application with respect to Licensed Product which ANIKA has not approved;

        (b)     sale or disposition of Licensed Products by OBI, its Affiliates,
distributors or sublicensees for any use other than the uses specified by the
accompanying package inserts;

        (c)     use, sale of disposition of Licensed Products by OBI, its
Affiliates, distributors or sublicensees in combination with devices or Licensed
Products not purchased hereunder, where such combined sale or disposition is the
sole cause of an infringement claim and whereas such Licensed Products would not
themselves be infringing;

        (d)     sale or disposition of Licensed Products by OBI, its Affiliates,
distributors or sublicensees in or for an application or environment for which
such Licensed Products were not approved by the FDA or other applicable
government or regulatory agency; or

                                       41
<Page>

        (e)     modifications of Licensed Products by OBI, its Affiliates,
distributors or sublicensees;

to the extent such uses, sales, dispositions or modifications give rise to the
claim, loss or liability and have not been approved by ANIKA.

13.5.   Notwithstanding anything contained in this Agreement to the contrary,
the Parties expressly agree that OBI shall have no liability to ANIKA under this
Section for claims, losses or liability of any kind based upon or related to:

        (a)     the design, manufacturing, packaging, sterilization, testing,
warehousing and handling of the Product by ANIKA through delivery to the common
carrier for shipment to the Shipping Point;

        (b)     ANIKA's use, sale or disposition of Licensed Products where such
Licensed Products incorporate changes made by ANIKA to the Specifications which
OBI has not approved;

        (c)     sale or disposition of Licensed Products by ANIKA for any use
other than the uses specified by the accompanying package inserts;

        (d)     sale or disposition of Licensed Products by ANIKA in or for an
application or environment for which such Licensed Products were not approved by
the FDA or other applicable government or regulatory agency; or

        (e)     modification of Licensed Products by ANIKA which OBI has not
approved and as to which OBI has the right to approve under this Agreement;

to the extent such activities, uses, sales, dispositions or modifications give
rise to the claim, loss or liability and have not been reviewed or approved by
ANIKA.

                                       42
<Page>

13.6.   If OBI or ANIKA intends to claim indemnification under this Section,
such Party (the "Claiming Party") shall (i) promptly notify the other Party in
writing of any claim or loss for which it intends to claim such indemnification,
(ii) cooperate fully with the other Party and its legal representatives in the
investigation of any claim or loss covered by this Section, and (iii) allow the
other Party to control the defense and/or disposition of such suit or claim;
provided that the Claiming Party shall have the right to participate at its own
expense through counsel of its own choosing. Neither Party shall have any
indemnification obligations hereunder to the extent that such Party's ability to
defend such suit or redress such loss is prejudiced by the Claiming Party's
failure to perform the obligations set forth in the preceding sentence. No claim
shall be settled for which any Indemnifying Party shall be liable without the
advance written consent of both the indemnifying Party and the Claiming Party,
which consent shall not be unreasonably withheld.

              ARTICLE XIV - ADDITIONAL APPLICATIONS AND INDICATIONS

14.1.   OBI FIRST RIGHT OF REFUSAL.

        (a)     ANIKA hereby grants to OBI a right of first refusal, as
described in this Section 14.1, to obtain rights to any new HA-based products
derived from ANIKA's R&D Pipeline, which are solely owned by ANIKA, acquired by
or licensed to ANIKA (provided ANIKA has rights to sublicense to others
thereunder) and developed for human use in the treatment of osteoarthritis,
(collectively referred to as the "ANIKA Potential Products").

        (b)     If at any time during the development of ANIKA Potential
Products, ANIKA determines in its sole discretion to seek a license,
distribution and/or development partner, ANIKA shall promptly notify OBI and
shall supply to OBI all available relevant information and data related thereto
as is reasonably necessary for OBI to make an informed decision of its interest
in obtaining license or distribution rights to the ANIKA Potential Product and
to develop a proposal for the commercial terms for such rights. The date of such
notification is hereinafter referred to as the "ANIKA Disclosure Date." OBI
shall have sixty (60) days from the ANIKA Disclosure Date to review the ANIKA
Potential Product and to determine if it wishes to negotiate distribution or
licensing arrangements with respect to such ANIKA Potential Product. During such
period, OBI may request that ANIKA provide OBI with additional information and
data which OBI reasonably considers relevant to OBI's consideration of the ANIKA
Potential Product, and ANIKA shall provide such additional information at OBI's
expense, but only to the extent such information is in existence and easily
accessed. If OBI does not wish to pursue negotiations for the distribution or
license of such ANIKA Potential Product and OBI so notifies ANIKA, or if such
sixty (60) day period expires without OBI notifying ANIKA as to its interest,
then ANIKA shall be free to enter into an agreement with a Third Party as to
that ANIKA Potential Product, as ANIKA shall determine at its sole discretion,
without any further restriction or obligation to OBI.

        (c)     If prior to the expiration of the sixty (60) day period referred
to in Section 14.1(b) OBI expresses in writing its interest in obtaining the
right to distribute or license the ANIKA

                                       43
<Page>

Potential Product, the Parties shall enter into good faith negotiations
regarding the right to distribute or license such ANIKA Potential Product within
the one hundred eighty (180) day period immediately following the ANIKA
Disclosure Date. If at the end of such one hundred eighty (180) day period the
parties are unable to reach a definitive agreement, and ANIKA does not wish to
continue the negotiations, as ANIKA shall determine at its sole discretion,
ANIKA shall be free to enter into an agreement with any Third Party without any
further restriction or obligation to OBI, except that it may not enter into an
agreement with a Third Party on terms less favorable to ANIKA then those terms
offered to ANIKA by OBI.

14.2.   ANIKA FIRST RIGHT OF REFUSAL.

        (a)     OBI (and its Affiliates) hereby grants to ANIKA a right of first
refusal, as described in this Section 14.2, to manufacture any new HA-based
products solely owned by OBI and/or its Affiliates or licensed to OBI and/or its
Affiliates, provided, so long as, in the case of and such licensed products, OBI
and/or its Affiliates has no obligations to use another manufacturer as part of
its license obligations (collectively referred to as the "OBI Potential
Products").

        (b)     If at any time during the development of OBI Potential Products,
OBI or an Affiliate determines in its sole discretion to seek a supplier or
manufactures for OBI Potential Products, OBI shall promptly notify ANIKA and
shall supply to OBI all available relevant information and data related thereto
as is reasonably necessary for ANIKA to make an informed decision of its
interest in supplying and/or manufacturing the OBI Potential Product and to
develop a proposal for the commercial terms for such supply rights. The date of
such notification is hereinafter referred to as the "OBI Disclosure Date." ANIKA
shall have sixty (60) days from the OBI Disclosure Date to review the OBI
Potential Product and to determine if it wishes to negotiate supply and/or
manufacturing arrangements with respect to such OBI Potential Product. During
such period, ANIKA may request that OBI provide ANIKA with additional
information and data which ANIKA reasonably considers relevant to ANIKA's
consideration of the OBI Potential Product, and OBI and its Affiliates shall
provide such additional information at ANIKA's expense, but only to the extent
such information is in existence and easily accessed. If ANIKA does not wish to
pursue negotiations for supply of such OBI Potential Product and ANIKA so
notifies OBI, or if such sixty (60) day period expires without ANIKA notifying
OBI as to its interest, then OBI or an Affiliate shall be free to enter into an
agreement with a Third Party as to that OBI Potential Product, as OBI shall
determine at its sole discretion, without any further restriction or obligation
to ANIKA.

        (c)     If prior to the expiration of the sixty (60) day period referred
to in Section 14.2(b) ANIKA expresses in writing its interest in obtaining the
right to supply the OBI Potential Product, the Parties shall enter into good
faith negotiations regarding the supply and/or manufacturing of such OBI
Potential Product within the one hundred eighty (180) day period immediately
following the OBI Disclosure Date. If at the end of such one hundred eighty
(180) day period, the Parties are unable to reach a definitive agreement, and
OBI does not wish to continue the negotiations, as OBI shall determine at its
sole discretion, OBI or an Affiliate shall be free to enter into an agreement
with any Third Party without any further restriction or

                                       44
<Page>

obligation to ANIKA, except that it may not enter into an agreement with a Third
Party on terms less favorable to OBI and its Affiliates than those terms offered
to OBI and its Affiliates by ANIKA.


                         ARTICLE XV - STEERING COMMITTEE

        (a)     OBI and ANIKA shall establish a Steering Committee (the
"Steering Committee") consisting of four (4) members. Each of OBI and ANIKA
shall appoint two (2) individuals to serve on the Steering Committee.

        (b)     Within thirty (30) days after the execution and delivery of this
Agreement by both Parties, ANIKA and OBI shall each appoint its initial
representatives to serve on the Steering Committee. Each Party may change its
representatives upon notice to the other Party.

        (c)     The Steering Committee shall be chaired by one representative of
either ANIKA or OBI for each successive twelve (12) month period during the Term
of this Agreement, and the chair shall alternate between the Parties. During the
first twelve (12) month period, the Steering Committee shall be chaired by a
representative of OBI.

        (d)     The Steering Committee shall meet at least two (2) times each
year during the Term of this Agreement, at such dates and times as agreed to by
the Parties, with the intention that the meetings should occur at least once
during each Calendar Quarter. Meetings in person shall alternate between the
offices of the Parties or such other place as may be mutually agreed upon by the
Parties. The Steering Committee may also convene or be polled or consulted from
time to time by means of telecommunications or correspondence, and members will
be deemed "present" at "meetings" for purposes of this Article 15 if
participating by such means. All decisions made or actions taken by the Steering
Committee shall require the affirmative vote of a majority of its entire
membership. A quorum for a meeting shall require at least one ANIKA member and
at least one OBI member.

        (e)     The duties and responsibilities of the Steering Committee shall
include: (i) reviewing and commenting on any Development being conducted by OBI;
(ii) reviewing and commenting on development relating to Orthovisc(R) being
conducted by ANIKA outside the Territory; (iii) review and comment on marketing
and sales activities being carried out by OBI in the Territory including
trademark and website issues, including review of an annual marketing plan; (iv)
review and comment on marketing and sales activities being conducted by ANIKA
outside the Territory; (v) discussing issues concerning whether to file for
Regulatory Approval and/or launch the Licensed Product in Mexico; and (vi)
review and discuss any manufacture and supply issues that may arise. In
connection with any meeting of the Steering Committee, the Parties will endeavor
to provide to the other Party all materials in connection with this Article
XV(e) at least five (5) Business Days in advance of such meeting.

                                       45
<Page>

                        ARTICLE XVI - DISPUTE RESOLUTION.

16.1.   DISPUTE RESOLUTION AND ARBITRATION.

        In the case of any Disputes (as defined below) between the Parties
arising from this Agreement, and in case this Agreement does not provide a
solution for how to resolve such disputes, the Parties shall endeavor to discuss
and negotiate in good faith towards a solution acceptable to both Parties and in
the spirit of this Agreement. If the Parties fail to reach agreement within
sixty (60) days, then the President of ANIKA and the President of OBI shall
discuss in good faith an appropriate resolution to the dispute. If these
executives fail to reach an amicable agreement within sixty (60) days, then
either Party may upon written notice to the other submit the dispute to binding
arbitration pursuant to Section 16.2.

16.2.   ARBITRATION.

        Any claim, dispute or controversy arising out of or in connection with
or relating to this Agreement, (including, without limitation, disputes with
respect to the rights and obligations of the Parties following termination) (a
"Dispute") not settled by the procedures set forth in Section 16.1 above shall
be adjudicated by arbitration in accordance with the Arbitration Proceedings as
set forth in Exhibit B attached hereto.


                            ARTICLE XVII - HSR FILING

17.1.   To the extent, that a Party concludes in good faith that it is required
to file or register this Agreement or a notification thereof in accordance with
applicable Laws with any Governmental Authority with regulatory jurisdiction
over enforcement of any applicable Competition Laws ("Governmental Antitrust
Authority"), including without limitation the U.S. Federal Trade Commission
Bureau of Competition ("FTC") and the U.S. Department of Justice Antitrust
Division ("DOJ"), such Party may do so. Without limiting the foregoing, the
Parties agree to make all necessary HSR Filings, if any, within seven (7)
business days after the Effective Date. Each Party shall be responsible for its
own costs, expenses, and filing fees associated with any filing with any
Governmental Antitrust Authority, including any HSR Filing.

17.2.   Subject to appropriate confidentiality protections, the Parties shall
work cooperatively in connection with obtaining the requisite approvals,
consents or orders of each applicable Governmental Antitrust Authority necessary
for the consummation of the transactions contemplated by this Agreement, and
shall keep each other apprised of the status of matters relating to the
obtainment of such approvals, consents or orders, including:

                (i)       cooperating with each other in connection with HSR
        Filings and filings under any foreign investments laws or any other
        Competition Laws;

                (ii)      furnishing to the other Party all information within
        its possession that is required for any HSR Filing or any application or
        other filing to be made by the other party pursuant to any foreign
        investment laws or any other Competition Laws in connection with the
        transactions contemplated by this Agreement;

                                       46
<Page>

                (iii)     promptly notifying each other of any communications
        from or with any Governmental Antitrust Authority with respect to the
        transactions contemplated by this Agreement;

                (iv)      promptly providing to the other Party copies of all
        communications with any Governmental Antitrust Authority relating to the
        transactions contemplated by this Agreement, or relating to any of the
        matters described in this Article XVII;

                (v)       not participating in any meeting or discussion with
        any Governmental Antitrust Authority in connection with proceedings
        under or relating to the HSR Act, any foreign investment laws or any
        other antitrust laws unless it consults with the other Party in advance,
        and, to the extent permitted by such Governmental Antitrust Authority,
        gives the other Party the opportunity to attend and participate thereat;
        and

                (vi)      consulting and cooperating with one another in
        connection with all analyses, appearances, presentations, memoranda,
        briefs, arguments, opinions and proposals made or submitted by or on
        behalf of any Party hereto in connection with proceedings under or
        relating to the HSR Act, any foreign investment laws or any other
        competition laws.

17.3.   The Parties agree to request early termination of the applicable waiting
period under the HSR Act in any HSR Filing. Each Party shall use its
commercially reasonable best efforts to secure termination of any waiting
periods under the HSR Act or other applicable law, to certify as soon as
practicable its substantial compliance with any requests for additional
information or documentary material that may be made under the HSR Act, and/or
to obtain the approval of any Governmental Antitrust Authority of the
transactions contemplated by this Agreement, including without limitation
promptly providing information and documents requested by any Governmental
Antitrust Authority and entering into good faith negotiations with any
Governmental Antitrust Authority to enter into a consent decree or other
arrangement to secure termination of such waiting periods or to obtain such
approval (provided, however, that nothing in this Article XVII shall prevent, or
be construed to prevent, either Party from agreeing to extend the waiting period
under the HSR Act in connection with good faith settlement negotiations with the
DOJ or FTC).

17.4.   As used in this Article, the following terms have the following
meanings:

        (a)     "HSR Act" means the Hart-Scott-Rodino Antitrust Improvements Act
of 1976, as amended, and the rule and regulations promulgated thereunder.

        (b)     "HSR Filing" means filings by ANIKA and OBI with the FTC and the
DOJ of a Notification and Report Form for Certain Mergers and Acquisitions (as
that term is defined in the HSR Act) with respect to the matters set forth in
this Agreement, together with all required documentary attachments thereto.

        (c)     "HSR Clearance Date" means the earlier of

                                       47
<Page>

                (i)       the date on which the FTC shall notify OBI and ANIKA
        of early termination of the applicable waiting period under the HSR Act,
        or

                (ii)      the day after the date on which the applicable waiting
        period under the HSR Act expires; or

                (iii)     the day after the date on which the seven (7) Business
        Day period referred to in Section 17.1 expires if no HSR Filings have
        been filed by that date.

17.5.   The licenses granted pursuant to Articles III, IV and VIII shall not be
effective until the HSR Clearance Date. In the event that an HSR Filing is
required and either:

        (a)     the FTC and/or the DOJ shall seek a preliminary injunction under
the HSR Act against ANIKA and OBI to enjoin the transactions contemplated by
this Agreement; or

        (b)     the HSR Clearance Date shall not have occurred on or prior to
June 1, 2004;

this Agreement may be terminated by either Party upon one (1) week written
notice (such termination to be deemed a termination pursuant to Section 12.2).


                          ARTICLE XVIII - MISCELLANEOUS

18.1.   RELATIONSHIP OF PARTIES.

        For the purposes of this Agreement, each Party is an independent
contractor and not an agent or employee of the other Party. Neither Party shall
have authority to make any statements, representations, or commitments of any
kind, or to take any action which shall be binding on the other Party, except as
may be explicitly provided for herein or authorized in writing.

18.2.   COUNTERPARTS.

        This Agreement may be executed in two or more counterparts, each of
which shall be deemed an original, and all of which together shall be deemed to
be one and the same instrument.

18.3.   HEADINGS.

        All headings in this Agreement are for convenience only and shall not
affect the meaning of any provision hereof.

18.4.   BINDING EFFECT.

        This Agreement shall inure to the benefit of and be binding upon the
Parties and their respective lawful successors and assigns.

                                       48
<Page>

18.5.   ASSIGNMENT.

        Neither Party may assign or transfer this Agreement or its rights and
obligations under this Agreement without the prior written consent of the other
Party, except to its Affiliates, which consent may be given or withheld in its
sole discretion, and any such assignment or transfer shall be null and void and
entitle the non-assigning party to terminate this Agreement forthwith.
Notwithstanding the foregoing, either Party must assign this Agreement (and
shall be permitted to do so without the consent of the other Party) in
connection with the sale of all or substantially all of its assets (whether by
merger, consolidation or otherwise); provided, however, that in no event shall
any such assignment release either Party from its responsibilities under this
agreement unless the assignee has agreed in writing to assume all of the
obligations of assignor hereunder.

18.6.   AMENDMENT AND WAIVER.

        This Agreement may be amended, supplemented, or otherwise modified at
any time, but only by means of a written instrument signed by both Parties. Any
waiver of any rights or failure to act in a specific instance shall relate only
to such instance and shall not be construed as an agreement to waive any rights
or fail to act in any other instance, whether or not similar.

18.7.   GOVERNING LAW.

        This Agreement and the legal relations among the parties shall be
governed by and construed in accordance with the laws of the State of New York,
USA, irrespective of any choice of laws or conflict-of-law principles.

18.8.   SEVERABILITY.

        In the event that any provision of this Agreement shall, for any reason,
be held to be invalid or unenforceable in any respect, such invalidity or
unenforceability shall not affect any other provision hereof, and this Agreement
shall be construed as if such invalid or unenforceable provision had not been
included herein.

18.9.   ENTIRE AGREEMENT.

        This Agreement constitutes the entire agreement between the parties with
respect to the subject matter hereof and supersedes any and all prior or
contemporaneous oral and prior written agreements and understandings.

18.10.  ADVICE OF COUNSEL.

        OBI and ANIKA have each consulted counsel of their choice regarding this
Agreement, and each acknowledges and agrees that this Agreement shall not be
deemed to have been drafted by one party or another and will be construed
accordingly.

                                       49
<Page>

18.11.  FORCE MAJEURE.

        Neither Party shall lose any rights hereunder or be liable to the other
Party for damages or losses on account of failure or delay of performance by the
defaulting Party if the failure or delay is occasioned by (i) any fire,
explosion, unusually severe weather, natural disaster or Act of God (except for
any fire or explosion that could reasonably have been prevented by ANIKA); (ii)
epidemic; any nuclear, biological, chemical, or similar attack; any other public
health or safety emergency; any act of terrorism; and any action reasonably
taken in response to any of the foregoing; (iii) any act of declared or
undeclared war or of a public enemy, or any riot or insurrection; (iv) any
disruption in transportation, communications, electric power or other utilities,
or other vital infrastructure; or any means of disrupting or damaging internet
or other computer networks or facilities; (v) any strike, lockout or other labor
dispute or action; (vi) any action taken in response to any of the foregoing
events by any civil or military authority; or (vii) any other event beyond such
Party's control, provided that the Party claiming force majeure has exerted all
reasonable efforts to avoid or remedy such force majeure; provided, however,
that in no event shall a Party be required to settle any labor dispute or
disturbance. Notwithstanding the foregoing, this Section 18.11 shall not operate
to relieve either Party from performance of any obligation for more than ninety
(90) days.

18.12.  FURTHER ACTIONS.

        Each Party agrees to execute, acknowledge and deliver such further
instruments, and to do all such other acts, as may be necessary or appropriate
in order to carry out the purposes and intent of this Agreement.

18.13.  NO TRADEMARK RIGHTS.

        Except as otherwise explicitly provided herein, no right, express or
implied, is granted by the Agreement to use in any manner the name "ANIKA" or
"OBI", or any other trade name or trademark of the other Party or its Affiliates
in connection with the performance of the Agreement.

18.14.  NOTICES.

        All notices hereunder shall be in writing and shall be deemed given if
delivered personally or by facsimile transmission (receipt verified), email
(receipt acknowledged), mailed by registered or certified mail (return receipt
requested), postage prepaid, or sent by express courier service, to the Parties
at the following address (or at such other address for a Party as shall be
specified by like notice; provided, that notices of a change of address shall be
effective only upon receipt thereof).

                                       50
<Page>

If to ANIKA,

                addressed to:

                ANIKA THERAPEUTICS INC.
                160 New Boston Street
                Woburn, MA 01801
                Attention:  Chief Executive Officer
                Facsimile:  (781) 932-3360
                Email: csherwood@anikatherapeutics.com

        With a copy to:

                Goodwin Procter LLP
                Exchange Place
                Boston, MA 02109
                Attention:  H. David Henken, P.C.
                Facsimile:  (617) 523-1231
                Email: dhenken@goodwinprocter.com

If to OBI:

                addressed to:

                Ortho Biotech Products, L.P.
                430 Route 22 East
                P.O. Box 6914
                Bridgewater, NJ 08807-0914
                Attention: President
                Facsimile: 908-529-4365
                Email: jhjohns@obius.jnj.com

                With a copy to:

                Office of General Counsel
                Johnson & Johnson
                One Johnson & Johnson Plaza
                New Brunswick, NJ 08933
                Facsimile:   732-524-2788
                Email: pjohnson@corus.jnj.com

        Each of the Parties consent to the personal jurisdiction of the U.S.
Federal Courts and agree to accept any legal process served upon such Party at
the addresses specified above for such Party.

                                       51
<Page>

18.15.  WAIVER.

        Except as specifically provided for herein, the waiver from time to time
by either of the Parties of any of their rights or their failure to exercise any
remedy shall not operate or be construed as a continuing waiver of same or of
any other of such Party's rights or remedies provided in this Agreement.

18.16.  BANKRUPTCY.

        All rights and licenses granted under or pursuant to this Agreement by
each Party are, and shall otherwise be deemed to be, for purposes of Section
365(n) of Title 11, U.S. code (the "Bankruptcy Code"), licenses of rights to
"intellectual property" as defined under Section 101(60) of the Bankruptcy Code.
The parties agree that OBI shall retain and may fully exercise all of its rights
and elections under the Bankruptcy Code. The licensor agrees, during the term of
this Agreement, to create and maintain current copies or, if not amenable to
copying, detailed descriptions or other appropriate embodiments, of all such
intellectual property. The Parties further agrees that in the event of the
commencement of a bankruptcy proceeding by or against it under the Bankruptcy
Code, the licensee shall be entitled to a complete duplicate of (or complete
access to, as appropriate) any such intellectual property, and all embodiments
of such intellectual property, and same, if not already in its possession, shall
promptly be delivered to licensee (a) upon such commencement of a bankruptcy
proceeding upon written request therefore by licensee, unless licensor elects to
continue to perform all of its obligations under this Agreement, or (b) if not
delivered under (a) above, upon the rejection of this Agreement by or on behalf
of licensor upon written request therefore by licensee.

18.17.  COMPLIANCE WITH ENVIRONMENT, SAFETY AND INDUSTRIAL HYGIENE.

        With respect to all environmental, safety and industrial hygiene matters
related to ANIKA's activities under this Agreement, ANIKA shall (i) comply with
all applicable laws and regulations issued by national, state and local
authorities, (ii) allow OBI to inspect ANIKA's facilities, such inspections to
be at reasonable times and upon reasonable notice, and (iii) implement
corrective action which may be reasonably requested by OBI to correct an
violations of laws or regulations regarding environmental, safety and industrial
hygiene

18.18.  CHILD LABOR EMPLOYMENT PRACTICES.

        ANIKA agrees to comply with the following PPC Corporate Policy relating
to the Employment of Child Labor:

        (a)     No person under the age of 16 shall be employed, and no other
young person (under age of 18) shall be employed unless such employment is in
compliance with the International Labor Organizations Convention 138 Concerning
Minimum Age;

        (b)     No young person (under age 18) shall be required to work more
than 48 regular hours and 12 hours overtime per week nor more than six (6) days
per week; and

                                       52
<Page>

        (c)     No young person (under age 18) shall be employed unless such
employment is in compliance with all applicable laws and regulations concerning,
age, hours, compensation, health and safety.

                                       53
<Page>

IN WITNESS WHEREOF, the undersigned have duly executed and delivered this
Agreement as a sealed instrument effective as of the date first above written.


ORTHO BIOTECH PRODUCTS, L.P.

BY:   Ortho Biotech Inc., its general partner


     BY: /s/ John Johnson
         --------------------------------------------
           John Johnson, President

DATE: December 20, 2003
      -----------------------------------------------


ANIKA THERAPEUTICS, INC.


By: /s/ Charles h. Sherwood
    -------------------------------------------------
        Charles H. Sherwood, Ph.D., President and CEO

DATE: December 20, 2003
      -----------------------------------------------

<Page>

                                    EXHIBIT A
                             PRODUCT SPECIFICATIONS

[******************************************************************************
*******************************************************************************
*******************************************************************************
*******************************************************************************
*******************************************************************************
*******************************************************************************
*******************************************************************************
*******************************************************************************
*******************************************************************************
*******************************************************************************
*******************************************************************************
*******************************************************************************
*******************************************************************************]

                                       A-1
<Page>

                                    EXHIBIT B

                                   ARBITRATION

        Any controversy or claim arising out of or relating to this Agreement
shall be resolved by arbitration before a single arbitrator in accordance with
the Commercial Arbitration Rules of the American Arbitration Association ("AAA")
then pertaining (available at www.adr.org), except where those rules conflict
with this provision, in which case this provision controls. Any court with
jurisdiction shall enforce this clause and enter judgment on any award. The
arbitrator shall be selected within twenty business days from commencement of
the arbitration from the AAA's National Roster of Arbitrators pursuant to
agreement or through selection procedures administered by the AAA. Within 45
days of initiation of arbitration, the parties shall reach agreement upon and
thereafter follow procedures, including limits on discovery, assuring that the
arbitration will be concluded and the award rendered within no more than six
months from selection of the arbitrator or, failing agreement, procedures
meeting such time limits will be designed by the AAA and adhered to by the
parties. In connection with the arbitration proceeding, the arbitrator shall
order the prompt exchange of relevant documents by each party; each party may
take up to two depositions as of right, and the arbitrator may in his or her
discretion allow additional depositions upon good cause shown by the moving
party; however, the arbitrator shall not have the power to order the answering
of interrogatories or the response to requests for admission. In connection with
any arbitration, each party shall provide to the other, no later than fourteen
(14) days before the date of the arbitration, the identity of all persons that
may testify at the arbitration and a copy of all documents that may be
introduced at the arbitration or considered or used by a party's witness or
expert. The arbitration shall be held in Boston, MA and the arbitrator shall
apply the substantive law of New York, except that the interpretation and
enforcement of this arbitration provision shall be governed by the Federal
Arbitration Act. From the date of initiation of arbitration and until such time
as any matter has been finally settled by arbitration, the running of the time
periods contained in Article VII as to which Party must cure a breach of this
Agreement shall be suspended as to the subject matter of the dispute. Prior to
commencement of arbitration, emergency relief is available from any court to
avoid irreparable harm. THE ARBITRATOR SHALL NOT AWARD EITHER PARTY PUNITIVE,
EXEMPLARY, MULTIPLIED OR CONSEQUENTIAL DAMAGES, OR ATTORNEYS FEES OR COSTS.

        Prior to commencement of arbitration, the parties must attempt to
mediate their dispute using a professional mediator from AAA, the CPR Institute
for Dispute Resolution, or like organization selected by agreement or, absent
agreement, through selection procedures administered by the AAA. Within a period
of 45 days after the request for mediation, the parties agree to convene with
the mediator, with business representatives present, for at least one session to
attempt to resolve the matter. In no event will mediation delay commencement of
the arbitration for more than 45 days absent agreement of the parties or
interfere with the availability of emergency relief.

                                       B-1
<Page>

                                    EXHIBIT C

                              FORM OF PRESS RELEASE

DRAFT 12/18/03


FOR IMMEDIATE RELEASE

Contacts:

ANIKA THERAPEUTICS, INC.            PONDEL/WILKINSON KLEIN

Charles Sherwood, Ph.D., CEO        Susan Klein (508) 358-4315
William Knight, CFO                 Rob Whetstone (323) 866-6050
(781) 932-6616

ANIKA THERAPEUTICS ANNOUNCES U.S. ORTHOVISC(R)LICENSE AND SUPPLY AGREEMENT WITH
ORTHO BIOTECH PRODUCTS, L.P.

        WOBURN, MA - December 22, 2003 - Anika Therapeutics, Inc. (NASDAQ:ANIK)
today announced the signing of an exclusive, multi-year U.S. licensing and
supply agreement with Ortho Biotech Products, L.P. for Anika's ORTHOVISC(R), a
highly purified, high molecular weight form of hyaluronic acid for treating pain
in patients suffering from osteoarthritis of the knee.

        Under the agreement, Anika will receive an initial payment of $2 million
and payments upon receipt of final marketing approval for ORTHOVISC from the
U.S. Food and Drug Administration (FDA), and other milestones. Earlier this
month, Anika announced that it had received a letter from the FDA stating that
an approval order will be issued for ORTHOVISC subject to a successful
inspection of Anika's manufacturing facility. In addition, Ortho Biotech will
fund post-marketing clinical trials for ORTHOVISC and development of future
products based on Anika's proprietary viscosupplementation technology. The
agreement covers the U.S. and Mexico. The effectiveness of certain of the
license provisions under the agreement may be subject to customary regulatory
approvals, including clearance under the Hart-Scott-Rodino Antitrust
Improvements Act.

        Anika Chief Executive Officer Charles H. Sherwood, Ph.D., said Anika
selected Ortho Biotech as its U.S. marketing partner for ORTHOVISC due to its
outstanding reputation for high quality products and customer service. "Ortho
Biotech is known for its strategy aimed at becoming a leader in the markets it
chooses to address. We

                                       C-1
<Page>

believe the company is an excellent partner for driving ORTHOVISC sales and
penetrating the U.S. market for viscosupplementation."

Designed to relieve pain and stiffness and improve joint mobility, ORTHOVISC has
been marketed outside of the United States since 1996. It is currently sold in
Canada and various European and Middle Eastern nations. The U.S. market for
viscosupplementation products is growing, with more than 10 million Americans
suffering from osteoarthritis of the knee.

ABOUT ORTHO BIOTECH PRODUCTS, L.P. (www.orthobiotech.com)

        In 1990, Ortho Biotech Products, L.P. was established in Raritan, N.J.,
as the first biotechnology subsidiary of Johnson & Johnson. Since that time,
Ortho Biotech and its worldwide affiliates have earned a global reputation for
researching, manufacturing and marketing innovative health care products that
extend and enhance the quality of patients' lives. Ortho Biotech, the
established market leader in Epoetin alfa therapy for anemia management across
multiple indications, focuses its research and marketing efforts in four
clinical areas: oncology, nephrology, immunology and critical care/surgery.

ABOUT ANIKA THERAPEUTICS, INC. (www.anikatherapeutics.com)

        Headquartered in Woburn, Mass., Anika Therapeutics, Inc. develops,
manufactures and commercializes therapeutic products and devices intended to
promote the repair, protection and healing of bone, cartilage and soft tissue.
These products are based on hyaluronic acid (HA), a naturally occurring,
biocompatible polymer found throughout the body. In addition to ORTHOVISC(R), a
treatment for osteoarthritis of the knee (not approved for sale in the U.S.),
Anika markets HYVISC(R) in the U.S. for the treatment of equine osteoarthritis
through Boehringer Ingelheim Vetmedica, Inc. and manufactures AMVISC(R) and
AMVISC(R) Plus, HA viscoelastic products for ophthalmic surgery, for Bausch &
Lomb. It also produces CoEaseTM, which is marketed by Advanced Medical Optics,
Inc., STAARVISCTM-II distributed by STAAR Surgical Company and ShellgelTM for
Cytosol Ophthalmics, Inc.

THE STATEMENTS MADE IN THIS PRESS RELEASE WHICH ARE NOT STATEMENTS OF HISTORICAL
FACT ARE FORWARD-LOOKING STATEMENTS WITHIN THE MEANING OF SECTION 27A OF THE
SECURITIES ACT OF 1933 AND SECTION 21E OF THE SECURITIES EXCHANGE ACT OF 1934,
INCLUDING, WITHOUT LIMITATION, STATEMENTS THAT MAY BE IDENTIFIED BY WORDS SUCH
AS "EXPECTATIONS," "REMAINS," "FOCUS," "EXPECTED," "PROSPECTIVE," "EXPANDING,"
"BUILDING," "CONTINUE," "PROGRESS," "EFFORTS," "HOPE," "BELIEVE," "OBJECTIVES,"
OPPORTUNITIES," "WILL," "SEEK," AND OTHER EXPRESSIONS WHICH ARE PREDICTIONS OF
OR INDICATE FUTURE EVENTS AND TRENDS AND WHICH DO NOT CONSTITUTE HISTORICAL
MATTERS IDENTIFY FORWARD-LOOKING STATEMENTS. THE STATEMENTS ARE BASED UPON THE
CURRENT BELIEFS AND EXPECTATIONS OF MANAGEMENT AND ARE SUBJECT TO SIGNIFICANT
RISKS AND UNCERTAINTIES. THE COMPANY'S ACTUAL RESULTS COULD DIFFER MATERIALLY
FROM ANY ANTICIPATED FUTURE RESULTS,

                                       C-2
<Page>

PERFORMANCE OR ACHIEVEMENTS DESCRIBED IN THE FORWARD-LOOKING STATEMENTS AS A
RESULT OF A NUMBER OF FACTORS, INCLUDING: THE RESULTS OF ITS RESEARCH AND
DEVELOPMENT EFFORTS AND TIMING OF REGULATORY APPROVALS; APPROVAL AND
COMMERCIALIZATION OF THE COMPANY'S PRODUCTS, AND, WITH RESPECT TO ORTHOVISC,
RISKS RELATING TO THE ABILITY OF THE COMPANY TO SUCCESSFULLY ADDRESS THE
REQUESTS OF THE FDA IN THE APPROVABLE LETTER AND THE TIMING OF THE COMPANY'S
EFFORTS TO DO SO, AS WELL AS THE TIMING OF ANY APPROVED ORDER; AND THAT THE
COMPANY'S NEW LICENSING AND SUPPLY ARRANGEMENTS WILL NOT RESULT IN MEANINGFUL
SALES OR WILL BE TERMINATED AT AN EARLIER DATE IN ACCORDANCE WITH ITS TERMS OR
THAT ANY OF THE MILESTONES CONTAINED IN THE COMPANY'S NEW LICENSING AND SUPPLY
AGREEMENTS WILL BE ACHIEVED. THERE CAN BE NO ASSURANCES THAT THE COMPANY'S
INCREASED UNIT SALES WILL MATERIALLY INCREASE PRODUCT REVENUE OR IMPROVE GROSS
MARGINS. CERTAIN OTHER FACTORS THAT MIGHT CAUSE THE COMPANY'S ACTUAL RESULTS TO
DIFFER MATERIALLY FROM THOSE IN THE FORWARD-LOOKING STATEMENTS INCLUDE THOSE SET
FORTH UNDER THE HEADINGS "BUSINESS," "RISK FACTORS AND CERTAIN FACTORS AFFECTING
FUTURE OPERATING RESULTS" AND "MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL
CONDITION AND RESULTS OF OPERATIONS" IN EACH OF THE COMPANY'S ANNUAL REPORT ON
FORM 10-K FOR THE YEAR ENDED DECEMBER 31, 2002, ITS QUARTERLY REPORT ON FORM
10-Q FOR THE QUARTER ENDED SEPTEMBER 30, 2003 AND CURRENT REPORTS ON FORM 8-K,
AS WELL AS THOSE DESCRIBED IN THE COMPANY'S OTHER PRESS RELEASES AND SEC
FILINGS.

                                      # # #

                                       C-3
<Page>

                                    EXHIBIT D

                         ANIKA'S INSURANCE REQUIREMENTS

1.0     DEFINITIONS

        "ANIKA"

2.0     INSURANCE REQUIREMENTS

        ANIKA shall procure and maintain, at all times, and at its own expense,
        until final completion of the work covered by the contract, and during
        the time period following the final completion if ANIKA is required to
        return and perform additional work, for any reason whatsoever, the types
        of insurance(s) specified below.

        A.      COMMERCIAL GENERAL LIABILITY

                ANIKA shall provide coverage on a Commercial General Liability
                Occurrence Coverage Form (or equivalent) with limits of not less
                than $1,000,000 each occurrence, $1,000,000 products/completed
                operations aggregate, $1,000,000 personal injury/advertising
                injury aggregate and $2,000,000 general aggregate. ANIKA will
                endeavor to inform OBI of any exclusions or amendments to the
                policy form which would result in direct impact to OBI. ANIKA's
                policy shall be specifically endorsed with Chubb Form to include
                OBI, its subsidiaries, and its directors, officers and
                employees, as an Additional Insured, as respects negligence
                caused by ANIKA as a result of this Agreement. ANIKA shall
                supply OBI with the above proof of insurance and forms as
                required upon the signing of this Agreement, but OBI's failure
                to demand such proof or forms shall not waive OBI's rights to
                such coverage as specified herein.

        B.      AUTOMOBILE LIABILITY

                ANIKA shall provide coverage on a Business Auto Policy Form (or
                equivalent) for hired and non-owned automobiles with a limit of
                liability in an amount no less than $1,000,000 each accident.

        C.      WORKERS' COMPENSATION

                ANIKA shall provide Workers' Compensation Form (or equivalent)
                in accordance with the laws of the State of MA, and any other
                applicable jurisdiction, covering all employees who are to
                provide service under this Agreement. Employers' Liability
                coverage is required with limits of not less than the following:

<Table>
                <S>                                                       <C>
                Bodily Injury by Accident.................................$500,000 Each Accident
                Bodily Injury by Disease..................................$500,000 Each Employee
                Bodily Injury by Disease..................................$500,000 Policy Limit
</Table>

                                       D-1
<Page>

        D.      EXCESS LIABILITY

                ANIKA shall provide Umbrella Liability coverage with a limit of
                liability no less than $5,000,000 each occurrence, $5,000,000
                aggregate.

        E.      MISCELLANEOUS

                All insurance companies must be authorized to do business in the
                States where business is being transacted covering all
                operations under this Agreement. All insurance companies must be
                rated A or better with a financial rating of VII or better in
                the most recent A. M. BEST'S RATING GUIDE.

                All insurers will endeavor to provide for thirty (30) days'
                prior written notice to OBI of cancellation.

                Certificates of insurance for all required coverages shall be
                provided to OBI prior to commencement of any work on the
                project.

                                       D-2
<Page>

                                    EXHIBIT E

                                QUALITY AGREEMENT


                                QUALITY AGREEMENT

                                     BETWEEN

                 PHARMACEUTICAL SOURCING GROUP AMERICAS (PSGA),
                          A JOHNSON & JOHNSON COMPANY,

                                       AND

                               ANIKA THERAPEUTICS

                     EFFECTIVE DATE:  MM/YY / REPLACES: NEW

                                       E-1
<Page>

                                QUALITY AGREEMENT

21 CFR Sec. 820.50 (Purchasing controls) of the Quality System Regulation states
"Each manufacturer shall establish and maintain procedures to ensure that all
purchased or otherwise received product and services conform to specified
requirements."

Toward this end, the PURPOSE of this Agreement is to ensure a mutual
understanding of key responsibilities to assure that those Pharmaceutical
Sourcing Group Americas (PSGA) products manufactured by Anika Therapeutics,
Inc., are produced according to specifications and comply with all governing
regulations and corporate policies. IT IS ACKNOWLEDGED THAT THIS WILL BE A
CONTINUOUSLY EVOLVING PROCESS.

                                       E-2
<Page>

                                TABLE OF CONTENTS

<Table>
<Caption>
SECTION TITLE                                                        PAGE
-------------                                                        ----
<S>                                                                  <C>
1.   MAIN CONTACTS                                                   4

2.   OBJECTIVES                                                      5

3.   SCOPE                                                           5

4.   DEFINITIONS                                                     5

5.   REGULATORY/GMP                                                  6

6.   MATERIALS                                                       7

7.   MANUFACTURING/PACKAGING                                         7

8.   STABILITY                                                       7

9.   PRODUCT COMPLAINTS                                              8

10.  EXPIRATION DATING / LOT NUMBERING                               8

11.  SPECIFICATIONS                                                  8

12.  NON-CONFORMANCES                                                9

13.  PRODUCT RELEASE/REJECTION                                       9

14.  VALIDATION                                                      9

15.  SUPPLIERS                                                       10

16.  CHANGE CONTROL                                                  10

17.  ADVERSE DRUG EXPERIENCES                                        10

18.  RECALLS                                                         10

19.  TECHNICAL SUPPORT                                               11

20.  AGREEMENT MAINTENANCE                                           11

21.  RESPONSIBILITIES                                                12

22.  APPROVALS                                                       17
</Table>

                                       E-3
<Page>

1.      MAIN CONTACTS:

PSGA:

[******************************************************************************
*******************************************************************************
*******************************************************************************
*******************************************************************************
*******************************************************************************
*******************************************************************************
*******************************************************************************
*******************************************************************************
*******************************************************************************
*******************************************************************************
*******************************************************************************
*******************************************************************************
*******************************************************************************]

ANIKA THERAPEUTICS:


Name: Frank Luppino

Title: Vice President - Operations

Telephone: 781-932-6616 x136

FAX: 781-932-3360

e-mail: fluppino@anikatherapeutics.com

                                       E-4
<Page>

  2.  OBJECTIVES:

2.1     To document the responsibilities of Anika Therapeutics and
     Pharmaceutical Sourcing Group Americas (PSGA) associated with the
     manufacture, packaging, testing, storage, and release of product.

2.2     To ensure a mutual understanding of key responsibilities, to ensure PSGA
     products are produced according to agreed upon specifications, and to
     ensure compliance with all applicable governing regulations and corporate
     policies.

2.3     It is acknowledged that this will be a continuously evolving process and
     that this Quality Agreement may be amended with concurrence from both
     parties as necessary.

  3.  SCOPE:

3.1     This agreement applies to the product(s) and locations listed below:

     PRODUCT(S):  ORTHOVISC(R)

     LOCATION(S): 236 West Cummings Park, Woburn, MA 01801

3.2     Any external manufacturing or packaging services provided for PSGA by an
     outside facility must conform at a minimum to the Quality Agreement terms
     and conditions. Anika Therapeutics is currently being contracted to provide
     these services. This Quality Agreement is being implemented to delineate
     the PSGA/Anika Therapeutics quality objectives and responsibilities.

3.3     This document constitutes a Quality Agreement only and is not intended
     to represent a purchase contract. The Quality Agreement does not represent
     or replace the Manufacturing and Supply Agreement or any other agreement
     and/or amendment(s) thereto between Anika Therapeutics and PSGA.

  4.  DEFINITIONS:

4.1     FDA: United States Food and Drug Administration or any successor entity
     (CBER-CDER).

4.2     PMA: Pre-market approval

                                       E-5
<Page>

4.3     QSR'S: Quality System Regulation, covering medical device good
     manufacturing practices as defined in the regulations promulgated under the
     Food, Drug, & Cosmetic Act (FDCA) 21 CFR Part 820.

4.4     PRODUCTS: Those products in Section 3.

4.5     RESPONSIBILITY: These abbreviations will be used to identify the
     responsibilities outlined in Section 21.

4.5.1          A = Audit
4.5.2          R = Primary Responsibility
4.5.3          D = Ultimate Decision Maker
4.5.4          S = Shared Responsibility

4.6     SPECIFICATIONS:

4.6.1          Master Formula
4.6.2          Test Methods
4.6.3          Product (WIP (Work in-process)/Finished) Requirements
4.6.4          Standard Operating Procedures (SOPs)
4.6.5          Labels & labelling

4.7     PRODUCT TERMS:

4.7.1          Bulk: Product stored in containers (drums, vessels, portable
     kettles etc.)

4.7.2          Work in Process (WIP): Product processed into its primary
     container needing further processing and/or packaging.

4.7.3          Finished Product: Product completely packaged and in its final
     stage. No further processing and/or packaging is required.

4.8     NON-CONFORMANCE: Any deviation from a specification as defined in
     Section 4.6.

  5.  REGULATORY / QSR:

5.1     Unless other wise specified, all information and documentation from
     Anika Therapeutics shall be provided to the PSGA QA contacts designated in
     Section 1 or their designee.

5.2     Anika Therapeutics shall manufacture, test, label, package, and store
     ORTHOVISC(R) in compliance with the QSR.

5.3     PMA:

                                       E-6
<Page>

5.3.1   Anika Therapeutics shall provide PSGA with copy of the annual report to
     the FDA not later than thirty (30) days from established dates.

5.4     GMP AUDITS:

5.4.1   For auditing purposes, PSGA will be granted full access to the Anika
     Therapeutics facility (except restricted areas) used for manufacturing,
     filing, packaging, testing, and storage of ORTHOVISC(R).
5.4.2   PSGA will provide Anika Therapeutics at least two weeks notification
     prior to scheduling an audit of the Anika Therapeutics facility.
5.4.3   The Anika Therapeutics response to any audit report findings must be
     received by PSGA within 30 days of receipt of an audit report unless
     otherwise agreed upon by the two companies.

5.5     VISITS BY THE FDA:

5.5.1   Within 2 business days Anika Therapeutics shall notify PSGA of any FDA
     inspection, or notice of inspection, relating to the ORTHOVISC(R) product.
5.5.2   Anika Therapeutics will notify PSGA by the end of the audit, or more
     frequently if appropriate, of any issues found during the FDA inspection
     that may impact ORTHOVISC(R) operations.
5.5.3   Anika Therapeutics will provide PSGA with copies of FDA 483 reports or
     similar reports relating to ORTHOVISC(R) or the facility.
5.5.4   PSGA will participate in the development and approval of action plans
     which involve actions to be taken by PSGA.

  6.  MATERIALS:

6.1     RAW MATERIALS: Anika Therapeutics will be responsible for
     inspection/testing and acceptance of all raw materials.

6.2     COMPONENTS: Anika Therapeutics will be responsible for all
     inspection/testing of components.

  7.  MANUFACTURING / PACKAGING:

7.1     Anika Therapeutics shall manufacture, package, test, and store the,
     bulk, WIP, and finished product in accordance with its approved
     specifications and current Good Manufacturing Practices.

7.2     The manufacture of any penicillin or steroid product will not be allowed
     in the same facility used for the manufacture of (PSGA product(s)).

                                       E-7
<Page>

7.3     Anika Therapeutics is responsible for releasing the finished product for
     PSGA review and the overall quality/compliance of the product (see
     Responsbilities - Section 21).

  8.  STABILITY / RETAIN SAMPLES:

8.1     Anika Therapeutics will be responsible for withdrawing the required
     number of samples and performing annual product stability analysis in
     accordance with approved test methods and at test intervals identified in
     the stability specifications.

8.2     Anika Therapeutics will maintain the required amount of retain samples
     of finished goods to perform full testing from every commercial lot
     manufactured at Anika Therapeutics.

8.3     All stability results will be available to PSGA upon request.

8.4     Anika Therapeutics will provide a copy of their stability protocol to
     PSGA.

  9.  PRODUCT COMPLAINTS:

9.1     OBI shall promptly communicate to ANIKA by facsimile, telephone or email
     (and confirm any such telephone communication as instructed at the time)
     any complaint received from users of the Licensed Product, in the
     configuration supplied by ANIKA.

9.2     Each notification of a complaint shall contain, but not be limited to,
     the lot number, dosage size, expiration date, indication for actual use and
     description of circumstances involved in the failure of the Unit(s) in
     question.

9.3     Each complaint notification will contain all the information available
     to OBI at that time, including all information then available which is
     required in the ANIKA Complaint Form, and a summary of the proposed action
     to be taken by OBI to comply with its legal obligations. OBI will provide
     additional information promptly as it becomes available.

9.4     OBI acknowledges that complaint investigation is the responsibility of
     ANIKA, but OBI reserves the right to directly contact its customers.

9.5     Anika Therapeutics will make reasonable efforts to complete their
     investigation, in writing, to all complaints within 30 business days of
     receipt, although some complaint investigations, due to their nature, may
     take longer to complete.

9.6     Anika Therapeutics will provide PSGA with summary complaint data on a
     semi-annual basis.

                                       E-8
<Page>

  10. EXPIRATION DATING / LOT NUMBERING:

10.1    Anika Therapeutics will be responsible for providing PSGA QA the
     formats, layouts and abbreviations for expiration dating and lot numbers.
     The assignment of expiration dates will be identified in the
     specifications.

10.2    The format, layout, and abbreviation for expiration date and lot number
     will be approved in writing by PSGA QA and be documented in the
     specification. All labels must comply with the PMA-approved labelling.

  11. NON-CONFORMANCES:

11.1    Anika Therapeutics will be responsible for investigating and documenting
     any non-conformance to any process, material or product. (Reference
     Sections 4.6 and 4.8).

11.2    Anika Therapeutics will provide PSGA with non-conformance summary data
     on a quarterly basis.

  12. PRODUCT RELEASE:

12.1    Upon determination by Anika Therapeutics that the ORTHOVISC(R) meets the
     required specifications it is approved for shipment to PSGA. PSGA will
     disposition the shipment after review and receipt of Anika Therapeutics QA
     documentation:

12.1.1     Anika Therapeutics is responsible for the storage of product prior to
      its receipt by PSGA
12.1.2     Shipment will be made to the designated PSGA facility
12.1.3     PSGA will specify approved carrier(s).
12.1.4     Carriers not specified by PSGA must be initially approved by PSGA
      prior to use by Anika Therapeutics.

12.2    Anika Therapeutics will forward the required documentation to PSGA QA
     for release.

12.2.1      Certificate of Analysis (COA)
12.2.2      Certificate of Compliance (COC)
12.2.3      Copies of the completed manufacturing record
12.2.4

12.3    PSGA is responsible for its acceptance decisions on finished
     ORTHOVISC(R) lots based on manufacturing site compliance with QSR's,
     including completed and approved batch record documentation and conformance
     to specifications.

                                       E-9
<Page>

12.4    Anika Therapeutics will maintain retain samples for each lot of raw
     materials for one (1) year past the expiration date.

12.5    Anika Therapeutics will not supply to PSGA product that has been
     reworked unless such rework is validated and approved within the PMA for
     the product.

  13. VALIDATION:

13.1    Anika Therapeutics will perform process, packaging, and cleaning
     validations as required by its procedures and in accordance with standard
     industry practice.

13.2    Anika Therapeutics will perform laboratory test method validations as
     required by its procedures and in accordance with standard industry
     practice.

13.3    Anika Therapeutics will develop protocols for required validations in
     accordance with standard industry practice.

  14. SUPPLIERS:

14.1    Anika Therapeutics will be responsible for conducting periodic audits of
     suppliers.

14.2    Anika Therapeutics will be responsible for qualification of new
     suppliers.

14.3    Anika Therapeutics will notify PSGA of any supplier-related quality
     issues impacting PSGA product(s).

  15. CHANGE CONTROL:

15.1    Anika Therapeutics will notify PSGA QA in advance of any changes in
     processes, testing, and materials prior to implementation if such changes
     are significant enough to affect finished product specifications or require
     FDA pre-approval submission.

15.2    Anika Therapeutics will provide PSGA with a summary of Change Control
     activities on a semi annual basis. This depends upon the type of change.

  16. MEDICAL DEVICE REPORTS:

16.1    ANIKA shall be responsible for notifying all applicable regulatory
     authorities of reportable events (including without limitation complaints)
     involving the Licensed Product for which ANIKA receives written
     notification, as required by applicable laws.

                                      E-10
<Page>

16.2    OBI shall notify ANIKA of potentially reportable events promptly but in
     no event later than twenty-four (24) hours after the event. In addition,
     all such notices by OBI shall be consistent with the requirements of law in
     the applicable jurisdictions.

16.3    Anika Therapeutics will provide PSGA with a summary of Medical Device
     Reports on a semi annual basis.

16.4    Anika Therapeutics and PSGA will work together to investigate reportable
     events and complaints, including gathering information from customers and
     end users.

  17. RECALLS:

17.1    Anika Therapeutics shall be responsible for coordinatingany recall of
     product from PSGA

17.2    PSGA shall be responsible for recalling product from end users and
     notifying end users of any field alert activities.

17.3    Anika Therapeutics shall forward all required recall-related information
     to PSGA on request, within two (2) calendar days of the request.

  18. TECHNICAL SUPPORT:

18.1    Technical support will be mutually agreed upon as situations arise.

  19. AGREEMENT MAINTENANCE:

19.1    This agreement shall be reviewed and amended annually or as needed.

19.2    Modifications/addenda can be made as required; any such modifications or
     addenda must be in writing and approved by the Anika Therapeutics and PSGA.

19.3    RECORD RETENTION: Original signed copies of this Agreement must be
     maintained for ten (10) years from the date of approval.

                                      E-11
<Page>

  20. RESPONSIBILITIES:

<Table>
<Caption>
                       DUTIES                                     ANIKA     PSGA      N/A        COMMENTS
-------------------------------------------------------------------------------------------------------------
<S>                                                                <C>       <C>      <C>    <C>
1.  RAW MATERIAL AND COMPONENTS
    -Specifications Development & Maintenance                      R, D      A
    -Specifications Control in Plant/SOPs                          R, D      A
    -Ordered from Approved Suppliers                               R, D      A
    -Receipt/Warehousing/Segregation of Materials                  R, D      A
    -Incoming inspection, sampling & testing                       R, D      A
    -Retest as necessary for release                               R, D      A
    -Retest for expiration                                         R, D      A
    -Inventory Management & Accountability - FIFO                  R, D      A
    -Destruction of Waste Materials                                R, D      A
    -Retain Samples (Active RM)                                    R, D      A
    -Labelling Control & Accountability                            R, D      A
    -Disposition of Materials (Release/Reject)                     R, D      A
-Use of Materials out of Specifications - Deviations               R, D      A
    -Suppliers Audits                                              R, D      A
    -Supplier Audit (API)                                                             X
</Table>

                                      E-12
<Page>

<Table>
<S>                                                                <C>       <C>      <C>    <C>
2.  BULK AND WORK-IN-PROGRESS
    -Specifications Development and Maintenance                    R, D      A
    -Manufacturing Directions Development & Maint.                 R, D      A
    -Specifications Control in Plant                               R, D      A
    -Area/Equipment Set Up & Inspection                            R, D      A
    -Sanitization - Manufacturing Areas                            R, D      A
    -Filling Machinery & Equipment Sanitization                    R, D      A
    -Line Clearance Procedure                                      R, D      A
    -Batch Records issuance & maintenance                          R, D      A
    -Equipment -maintenance, integrity & calibration               R, D      A
    -Environmental & Personnel monitoring                          R, D      A
    -Primary batch record review                                   R, D      A
    -Cleaning Records & Logs                                       R, D      A
    -Dispensing records & logs                                     R, D      A
    -In-Process Sampling analysis & testing                        R, D      A
    -Deviations from Bulk Finished Parameters Specifications         S       S
-Development of Bulk and WIP Parameters/Annual Rev.                  R       A
    -Documentation System and SOPs/Int'l                           R, D      A
    -Changes to Process Parameters*                                  S       S
    -Final Product Sampling and testing                            R, D      A
    -Disposition of Product (release/reject)                         R       A
    -Destruction of Waste Materials                                R, D      A
</Table>

        *To the extent changes meet the threshold in the "Change Control"
        section of this agreement.

                                      E-13
<Page>

<Table>
<Caption>
                       DUTIES                                     ANIKA     PSGA      N/A        COMMENTS
-------------------------------------------------------------------------------------------------------------
<S>                                                                <C>       <C>      <C>    <C>
3.  PACKAGING
    -Specifications Development & Maintenance                      R, D      A
    -Specifications Control in Plant                               R, D      A
    -Line Clearance Procedure                                      R, D      A
    -Environmental & Personnel monitoring                          R, D      A
-Labelling controls & reconciliation (bottle, PI, carton)          R, D      A
    -Lot number, control                                           R, D      A
    -Expiration Date Control                                       R, D      A
    -Expiration Dating Development                                   S       A
    -Cartoning & Bundling                                          R, D      A
    -Palletizing and Storage                                       R, D      A
    -Quarantine and Storage SOPs                                   R, D      A
    -Deviations from Packaging Specifications                        S       S
    -Product Sampling, Inspection and testing                      R, D      A

4.  PRODUCT RELEASE
    -Specifications Development and Maintenance                    R, D      A
    -Quarantine Release SOPs                                       R, D      A
    -Product Release SOPs                                          R, D      A
    -Standard Analytical & Microbiological Tests                   R, D      A
    -Batch record review                                           R, D      A
-Environmental monitoring review (air, water, steam, pressure)     R, D      A
    -Tests Problem Resolution procedures                           R, D      A
-Deviation(s) reporting, investigations & documentation              S       S
-Finished Goods Re-testing                                           R       D
    -Disposition of Product (release/rejection)                      R       D
-Evaluation of Finished Product with deviations from specs           R       D
</Table>

                                      E-14
<Page>

<Table>
<S>                                                                <C>       <C>      <C>    <C>
    -Destruction of Waste Materials                                R, D      A
-Quarantine & Quarantine Release procedures/Execute based on SOP   R, D      A
</Table>

                                      E-15
<Page>

<Table>
<Caption>
                       DUTIES                                     ANIKA     PSGA      N/A         COMMENTS
-------------------------------------------------------------------------------------------------------------
<S>                                                                <C>       <C>      <C>    <C>
5.  STABILITY PROGRAM
    -Stability Protocols/Documentation System                      R, D      A
    -Documentation Systems/SOPs in Plant                           R, D      A
    -Retain Sampling                                               R, D      A
    -Stability Testing                                             R, D      A
-New test Methods Development
(validation, transfer, documentation)                              R, D      A
    -Test Methods Implementation                                   R, D      A
    -Equipment Records, calibrations, validations                  R, D      A
    -Result Handling
        -Result Reporting to PSGA                                    R       A
        -Stability alert - OOS Results                               R       A
    -Reporting (Internal, External)                                R, D      A
    -FDA Field Alert                                                 S       S

6.  CUSTOMER COMPLAINTS
    -Standard Operating Procedure-in plant                         R, D      A
    -Logging/Receipt                                               R, D      A
    -Retain Sampling, handling & testing                           R, D      A
    -Analysis
       -in plant laboratory                                        R, D      A
       -outside laboratory                                           R       D
    -Synchrony on records with PSGA                                                   X
    -Reporting (Internal & External)                               R, D      A
    -FDA Field Alert                                                 S       S
</Table>

                                      E-16
<Page>

<Table>
<Caption>
                       DUTIES                                     ANIKA     PSGA      N/A         COMMENTS
-------------------------------------------------------------------------------------------------------------
<S>                                                                <C>       <C>      <C>    <C>
7.  GENERAL & FACILITY
    -SOPs, Guidelines, Practices and Policies                      R, D      A
    -Monitoring, Maintenance, Calibration of
        -Water Systems (DI, WFI)                                   R, D      A
        -Clean Air System                                          R, D      A
        -HVAC System                                               R, D      A
        -Steam System                                              R, D      A
        -Pressure System                                           R, D      A
    -Annual Product Review
        -Data Collection                                           R, D      A
-Written Report (Process, Analytical & Complaint Data)             R, D      A
    -General Records Systems                                       R, D      A
        -Documentation System in Plant                             R, D      A
        -Records Retention (Batch Records)                         R, D      A
    -Change Control in Plant                                       R, D      A
    -Retain Samples Management                                     R, D      A
    -Training and Education                                        R, D      A
    -Process and Product Validation
        -Facility and Systems                                      R, D      A
        -Equipment                                                 R, D      A
        -Product                                                   R, D      A
        -Revalidation                                              R, D      A
        -New Products                                                                 X
    -Quality Alert System                                          R, D      A

8.  COMPLIANCE & PMA-RELATED
- Adverse Drug Experience Reporting                                R,D       A
- PMA compliance & Annual Report to FDA                            R,D       A
- Recall coordination                                               S        S
</Table>

                                      E-17
<Page>

      A = Audits
      R = Primary Responsible
      D = Ultimate Decision Maker
      S = Shared Responsibility/Agree

                                      E-18
<Page>

  22. APPROVAL SIGNATURES

  THIS AGREEMENT HAS BEEN REVIEWED AND APPROVED BY:

<Table>
<Caption>
               APPROVED BY:                   DATE:
    --------------------------------------------------
       <S>                                    <C>
            Anika Therapeutics



          (Site QA Manager, PSGA)

       (QA Director Ext. Mfg., PSGA)

       (VPQA Pharmaceuticals, PSGA)
</Table>

                                      E-19
<Page>

                                    EXHIBIT F

                              ANIKA COMPLAINT FORM

COMPLAINT FORM

COMPLAINT FILE NUMBER:                                       COMPLAINANT:
DATE COMPLAINT RECEIVED:                                     Address
METHOD OF COMMUNICATION OF COMPLAINT:                        Address
                                                             Phone number

PRODUCT NAME:                                                PRODUCT LOT NUMBER:

COMPLAINT:

ATTACH APPROPRIATE DOCUMENTATION TO THIS FORM.
1.      Date Complaint Receipt Acknowledged:
2.      Was there a death, serious injury or serious illness?
3.      Any relationship of the device/drug to the reported incident?
4.      Is the event described in product labeling?
5.      Description of specific medical intervention action taken or withheld:

6.      Physician name:
7.      Description of patient condition:

8.      ADE or MDR Reportable Event? YES: ________ NO: ________ ( If yes,
        proceed to #4.)
        IF NO STATE RATIONALE:


        Vigilance Reporting? YES: ________ NO: ________ Date Reported:
        _____________

9.      DATE FAILURE INVESTIGATION INITIATED: If investigation was not
        initiated, state reason:


10.     CAPA #: If corrective action is not required, state rationale:

11.     DATE FAILURE INVESTIGATION CLOSED:

                                       F-1
<Page>

REQUIRED DOCUMENTATION OBTAINED AND COMPLAINT CLOSED:

DATE OF CLOSE-OUT TO COMPLAINANT: ____________________


QS/RA SIGNATURE: __________________________________      DATE:  ________________

                                       F-2