EXHIBIT 10.33




	


EXHIBIT  10.33



CHANGE
OF CONTROL AGREEMENT



        THIS
CHANGE OF CONTROL AGREEMENT (“Agreement”) is effective as of the
30th day of March, 2004 (the “Effective Date”), by and
between AXONYX, INC. (the “Company”), and Gosse Bruinsma (the
“Executive”).



        WHEREAS,
the Executive is currently employed by the Company;



        WHEREAS,
the Board of Directors of the Company (the “Board”) has determined
that it is in the best interests of the Company and its stockholders to assure
that the Company will have the continued services and dedication of the
Executive, notwithstanding the possibility, threat or occurrence of a Change of
Control (as defined herein); and



        WHEREAS,
in order to accomplish the foregoing objective, the Board has authorized and
directed the Company to enter into this Agreement.



        NOW,
THEREFORE, in consideration of the premises, the mutual covenants and agreements
contained in this Agreement, and other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, the Company and the
Executive hereby agree as follows:



        1.
Term. The term of this Agreement (“Term”) shall commence on the
Effective Date and shall continue until the earlier of: (a) ninety (90) days
after the Executive’s termination of employment with the Company if no
Change of Control shall have then been commenced, publicly announced or
occurred; or (b) one (1) year after a Change of Control shall have occurred.



        2.
Accelerated Vesting of Options; Severance Payments. If:










	 	        (a)
a Change of Control shall have occurred and the Executive’s employment with  the
Company is terminated by the Executive for Good Reason during the Term; or






	 	        (b)
during the period from ninety (90) days prior to the commencement or public  announcement
of a Change of Control until one (1) year after a Change of Control  shall have occurred,
the Executive’s employment with the Company is  terminated by the Company other than
for Cause;






	


then (i) all unvested
options granted to the Executive by the Company or any successor entity prior
to, simultaneously with or in connection with the Change of Control shall vest
immediately prior to such resignation or termination of employment described in
subsection 2(a) or (b) above, (ii) all outstanding options shall remain
exercisable for a period of one year following the termination of employment,
and (iii) the Company shall pay to the Executive (in addition to any accrued but
unpaid base salary and/or bonus and any unreimbursed business and/or medical
expenses and/or other accrued but unpaid benefits under the Company’s
employee benefit programs as of the date of such resignation or termination of
employment), in a single lump sum payment, within thirty (30) days after any
such resignation or termination, an amount equal to the sum of:










	 	        (1)
two hundred percent (200%) of the Executive’s highest annual base salary in  effect
during the one (1) year period immediately preceding such resignation or  termination,
plus






	


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	 	        (2)
the greater of the annual bonus the Executive received with respect to the  immediately
preceding fiscal year of the Company and the current annual target  bonus in effect at
the time of such resignation or termination.






	


        3.
Good Reason.










	 	        (a)
As used in this Agreement, the term “Good Reason” means:






	 	        (i)
a material diminution in the nature of the Executive’s authority, duties,
responsibilities or status (including offices, titles, reporting requirements  and
supervisory functions), from those in effect immediately prior to the Change  of Control;
or






	 	        (ii)
the required relocation of the Executive’s place of employment to a  location in
excess of thirty (30) miles from the Executive’s place of  employment at the time
the Executive terminates employment, except for required  travel on Company business to
an extent substantially equivalent to the  Executive’s business travel obligations
immediately prior to the Change of  Control; or






	 	        (iii)
any substantial reduction by the Company of the Executive’s base salary, or  a
reduction in the Executive’s bonus opportunities, profit sharing  opportunities, or
other incentive opportunities from those in effect immediately  prior to the Change of
Control.






	 	        (b)
If, at any time during the Term of this Agreement, whether before or after the
occurrence of a Change of Control, the Executive receives a written description  from the
Company of the nature of the Executive’s authorities, duties,  responsibilities,
status, salary, bonus and other employee benefits, or job  location, and the Executive
thereafter accepts in writing such new authority,  duties, responsibilities, status,
salary, bonus and other employee benefits, or  job location (“New Position”)
with the Company without determining  that the New Position causes a Good Reason as set
forth in Section 2(a) hereof,  then for the remainder of the Term, the New Position shall
be the authorities,  duties, responsibilities, status, salary, bonus and other employee
benefits, or  job location to be used by the Executive in determining whether Good Reason
has  occurred thereafter pursuant to Section 2(a) hereof.






	


        4.
Change of Control. As used herein, the term “Change of Control”
shall mean the occurrence with respect to the Company of any of the following
events:










	 	        (a)
An acquisition of any voting securities of the Company (the “Voting  Securities”)
by any “Person” (as the term Person is used for  purposes of Section 13(d) or
14(d) of the Securities Exchange Act of 1934, as  amended (the “Exchange Act”))
immediately after which such Person has  “Beneficial Ownership” (within the
meaning of Rule 13d-3 promulgated  under the Exchange Act) of fifty percent (50%) or more
of the combined voting  power of the then outstanding Voting Securities;






	 	        (b)
The individuals who, as of the date hereof, are members of the Board (the  “Incumbent
Board”), cease for any reason to constitute at least a  majority of the Board;
provided, however, that if the election or nomination for  election by the Company’s
stockholders of any new director was approved by  a vote of at least a majority of the
Incumbent Board, such new director shall,  for purposes of this Agreement, be considered
as a member of the Incumbent  Board; provided, further, however, that no individual shall
be considered a  member of the Incumbent Board if (i) such individual initially assumed
office as  a result of either an actual or threatened “Election Contest” (as
described in Rule 14a-11 promulgated under the Exchange Act) or other actual or
threatened solicitation of proxies or consents by or on behalf of a Person other  than
the Board (a “Proxy Contest”), including by reason of any  agreement intended
to avoid or settle any Election Contest or Proxy Contest, or  (ii) such individual was
designated by a Person who has entered into an  agreement with the Company to effect a
transaction described in clause (i) or  (iii) of subsection (c) below; or






	


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	 	        (c)
Approval by stockholders of the Company of:






	 	        (i)
A  merger, consolidation or reorganization involving the Company, unless,






	 	        (1)
the stockholders of the Company immediately before such merger, consolidation or
reorganization, own, directly or indirectly, immediately following such merger,
consolidation or reorganization, at least a majority of the combined voting  power of the
outstanding Voting Securities of the corporation (the  “Surviving Corporation”)
in substantially the same proportion as their  ownership of the Voting Securities
immediately before such merger, consolidation  or reorganization;






	 	        (2)
the individuals who were members of the Incumbent Board immediately prior to the
execution of the agreement providing for such merger, consolidation or  reorganization
constitute at least a majority of the members of the board of  directors of the Surviving
Corporation; and






	 	        (3)
no Person (other than any Person who, immediately prior to such merger,  consolidation or
reorganization, had Beneficial Ownership of a majority or more  of the then outstanding
Voting Securities) has Beneficial Ownership of a  majority or more of the combined voting
power of the Surviving  Corporation’s then outstanding Voting Securities.






	 	        (ii)
A complete liquidation or dissolution of the Company; or






	 	        (iii)
An agreement for the sale or other disposition of all or substantially all of  the assets
of the Company to any Person.






	


        Notwithstanding
the foregoing, a Change of Control shall not be deemed to occur solely because
any Person (the “Subject Person”) acquired Beneficial Ownership of
more than the permitted amount of the outstanding Voting Securities as a result
of the acquisition of Voting Securities by the Company which, by reducing the
number of Voting Securities outstanding, increased the proportional number of
shares Beneficially Owned by the Subject Person; provided that if a Change of
Control would occur (but for the operation of this sentence) as a result of the
acquisition of Voting Securities by the Company, and after such share
acquisition by the Company, the Subject Person becomes the Beneficial Owner of
any additional Voting Securities Beneficially Owned by the Subject Person, then
a Change of Control shall be deemed to have occurred.



        5.
Cause. The term “Cause” shall mean (1) the willful failure of
the Executive substantially to perform the duties of his employment (other than
any such failure resulting from incapacity due to physical or mental illness)
for at least [10] days after a demand for substantial performance is delivered
to the Executive by the Company which specifically identifies the manner in
which the Company believes the Executive has not substantially performed the
duties of his employment; (2) the Executive’s engaging in conduct that
constitutes neglect or willful misconduct in carrying out the duties of his
employment or that is injurious to the Company or any of its affiliates; (3) the
Executive’s conviction of, or entering a plea of guilty, nolo contendere
(or similar plea) to a crime that constitutes a felony or any crime of moral
turpitude; (4) the Executive’s directly or indirectly selling, passing on
or otherwise using or disclosing without permission any confidential information
of the Company; or (5) the Executive’s direct or indirect participation in
business activities in competition with the Company.



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        6.
Governing Law. This Agreement shall be governed by and construed in
accordance with the laws of the State of New York, without reference to the
choice of law principles thereof.



        7.
Assignability. This Agreement is personal to the Executive and without
the prior written consent of the Company shall not be assignable by the
Executive other than by will or the laws of descent and distribution. This
Agreement shall inure to the benefit of and be enforceable by the
Executive’s legal representatives and heirs. This Agreement shall inure to
the benefit of and be binding upon the Company and its successors and assigns.
The Company shall require any corporation, entity, individual or other person
who is the successor (whether direct or indirect, by purchase, merger,
consolidation, reorganization, or otherwise) to all or substantially all of the
business and/or assets of the Company, to expressly assume and agree to perform,
by a written agreement in form and substance reasonably satisfactory to the
Executive, all of the obligations of the Company under this Agreement, prior to
or contemporaneously with a Change of Control. As used in this Agreement, the
term “Company” shall mean the Company as defined above and any
successor to its business and/or assets as described herein which assumes and
agrees to perform this Agreement by operation of law, written agreement, or
otherwise.



        8.
Waiver. This Agreement may not be changed or terminated without the prior
written agreement of both the Company and the Executive. The waiver of any
breach of any term or condition of this Agreement shall not be deemed to
constitute the waiver of any breach of the same or any other term or condition
of this Agreement.



        9.
Severability. In the event any provision of this Agreement is found to be
unenforceable or invalid, such provision shall be severable from this Agreement
and shall not affect the enforceability or validity of any other provision of
this Agreement. If any provision of this Agreement is capable to two
constructions, one of which would render the provision void and the other that
would render the provision valid, then the provision shall have the construction
that renders it valid.



        10.
Additional Agreement. This Agreement is in addition to (and, except as
specifically set forth herein, does not supercede or modify any of the
provisions of) the Company’s 2000 Stock Option Plan, which shall remain in
full force and effect. For the avoidance of doubt, certain stock options granted
to the Executive may automatically vest under certain circumstances pursuant to
the Company’s 2000 Stock Option Plan even though no Change of Control has
been commenced, publicly announced or occurred as contemplated hereby.



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        IN
WITNESS WHEREOF, the parties have executed this Agreement as of the Effective
Date.










			AXONYX, INC:



By: /s/ MARVIN S. HAUSMAN

——————————————
Name/Title: Marvin S. Hausman,

Chairman of the Board and CEO










			EXECUTIVE:



/s/ GOSSE BRUINSMA

——————————————
Gosse Bruinsma







	


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