UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

JUL 2 0 2015 

MEMORANDUM 

OFFICE OF CHEMICAL SAFETY 

AND POLLUTION PREVENTION 

SUBJECT: BEAD Chemical Profile (BCP) for Registration Review: Antimycin A (006314) 

FROM: 

THRU: 

Carl Chen, Plant Pathologist 

· Biological Analysis Branch 

Donald Atwood, Entomologist 

Science Information and Analysis Branch ~ ~~ 

Derek Berwald, Economist ~ ~ ~ Michelle Ranville, Economist 

Economic Analysis Branch 

Biological and Economic Analysis Division (7503P) .-.-

~J//'L :_ ~I' ;J,.,._e.r ::,J,,,..e ~ Arnet Jones, Chief 

Biological 

Diann Sims, 

Analysis 

Chief 

Bran

M 

~ 

. Science Information and Analysis Branch 

Timothy Kiely, Chief m 011Ao }vu ~ ·fl.x' Tim~ ILt.t u..., Econom~c Analysis Branch J 

Biological and Economic Analysis Division (7503P) 

TO: Eric Miederhoff, Chemical Review Manager 

Risk Management and Implementation Branch 1 

Pesticide Re-evaluation Division (7508P) 

Product Review Panel date: July 8, 2015 

The Biological and Economic Analysis Division (BEAD) Chemical Profile (BCP) provides an 

overview of the pest management role and quantitative usage information available for a 

pesticide. Information provided in this BCP may be used by stakeholders (e.g., users and 

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registrants), Office of Pesticide Programs (OPP) risk and benefit assessors, OPP risk managers, 

and the general public during the Registration Review process of antimycin A. 

Antimycin A was registered in the United States in 1960. Its use sites include aquaculture, lakes, 

ponds, streams, channels, and intermittently flooded areas. It has only one end-use product, 

Fintrol® Fish Toxicant Kit, formulated as a soluble concentrate and registered under Section 3 of 

the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). Water treatment is made when 

needed through spray equipment, boat bailer, or drip stations. 

Antimycin A is registered for control of unwanted fish as a fish toxicant. It kills by interfering 

with the respiration of body cells with a complete kill at high concentrations to eliminate all fish 

or a selective kill at lower concentrations to eliminate only smaller or more sensitive species. 

Approximately 20 fish species or groups are listed on the label that include carp, trash fish, 

catfish, freshwater drum, and suckers. 

BEAD's previous work on antimycin A has included an alternatives analysis as part of the risk 

mitigation and reregistration process and an evaluation for a low volume minor use data waiver 

request (Kaul et al., 2006; Kaul, 2007; Donaldson, 2009). BEAD's findings include: 1) there are 

only two registered broad spectrum piscicides, antimycin A and rotenone; 2) there are 

insufficient efficacious alternatives and antimycin A has niche uses so that it is useful for 

endangered fish repopulation efforts; and 3) it is a minor use as defined by FIFRA Section 2(ll) 

and there is limited economic incentive to produce requested data in order to continue its 

registration. 

There have been no BEAD benefits assessments or BEAD assessments for FIFRA Section 18 

emergency exemption requests for antimycin A in the last 10 years. While an emergency 

exemption request may yield information about a chemical's importance, the lack of a FIFRA 

Section 18 assessment by BEAD is not an indicator of the relative importance of the chemical. 

Quantitative usage information for antimycin A is not available. In the event more information 

is needed concerning its use· or importance during registration review, the following may be 

requested: 1) total pounds of active ingredient applied per year on a national and/or regional 

basis; 2) acreage or percent area treated; 3) application rates: typical and maximum; 4) frequency 

and intervals of application; and 5) efficacy information/product performance. 

REFERENCES 

Donaldson D. 2009. Evaluation of BEAD related aspects of the low volume minor use data 

waiver request for antimycin A. EPA OPP Biological and Economic Analysis Division. 

Kaul M, Zinn N, Faulkner J. 2006. Alternatives analysis for antimycin A and rotenone in lakes 

and streams. EPA OPP Biological and Economic Analysis Division. 

Kaul M. 2007. Response to public comments on alternatives analysis for antimycin A in lakes 

and streams. EPA OPP Biological and Economic Analysis Division. 

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