Flonicamid Dietary Exposure Assessment DP Barcode: D397279

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF CHEMICAL SAFETY

AND POLLUTION PREVENTION

MEMORANDUM

DATE: September 27, 2012 

SUBJECT: Revised Flonicamid Chronic Aggregate Dietary (Food and Drinking Water) 

Exposure and Risk Assessments for an IR-4 Section 3 Registration Action on 

Berry Low-Growing Subgroup 13-07G, Cucumber for Greenhouse Use Only, and 

Rapeseed Sub-group 20A. 

PC Code: 128016 DP Barcode: D397279

Decision No.: 457726 Registration Nos.: 71512-9, 71512-10

Petition No.: 1E7942 Regulatory Action: Section 3 Registration

Assessment Type: Single Chemical Case No.: NA

TXR No.: NA CAS No.: 158062-67-0

MRID No.: NA 40 CFR: §180.613

REVIEWER: Cassi L. Walls, Ph.D., Senior Biologist

Risk Assessment Branch III

Health Effects Division (7509P)

THROUGH: Julie Van Alstine, MPH, Environmental Health Scientist

Amelia M. Acierto, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division (7509P)

Jeff Dawson, Acting Branch Chief

Risk Assessment Branch III

Health Effects Division (7509P)

TO: Barry O’Keefe, Risk Assessor

Risk Assessment Branch III

Health Effects Division (7509P)

Executive Summary

Chronic aggregate dietary (food and drinking water) exposure and risk assessments were

conducted using the Dietary Exposure Evaluation Model software with the Food Commodity

Intake Database (DEEM-FCID) Version 3.16, which uses food consumption data from the U.S. 

Department of Agriculture’s National Health and Nutrition Examination Survey, What We Eat in 

America, (NHANES/WWEIA). This dietary survey was conducted from 2003 to 2008. The 

analysis was performed to support a petition for tolerances in conjunction with an IR-4 petition 
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for a Section 3 registration for the new uses of flonicamid on berry low-growing subgroup 13-

07G, cucumber (for greenhouse use only), and rapeseed sub-group 20A.

Chronic Dietary Exposure Results and Characterization

Tolerance-level residues combined with 100% crop treated were used to determine the chronic 

dietary exposure and risk estimates. Drinking water was incorporated directly into the dietary

assessment. The chronic dietary exposure estimates for food and drinking water are below 

HED’s level of concern for the general U.S. population [11% of the chronic population adjusted 

dose (cPAD)] and the most highly exposed population subgroup, children 1 – 2 years old (28%

of the cPAD). 

Acute Dietary Exposure Results and Characterization

An acute dietary risk assessment was not performed as flonicamid has no acute toxicological 

endpoint.

Cancer Dietary Exposure Results and Characterization

A cancer dietary assessment was not conducted as flonicamid has been determined to be 

“Suggestive Evidence of Carcinogenicity, but Not Sufficient to Assess Human Carcinogenic 

Potential”.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to point 

of departure (POD) (e.g., NOAEL, LOAEL) divided by the required uncertainty or safety 

factors.

For non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% 

of the PAD. HED is generally concerned when estimated cancer risk exceeds one in one million. 

References which discuss the acute and chronic risk assessments in more detail are available on 

the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A 

User’s Guide,” 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day12/6061.pdf; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for flonicamid was conducted by Amelia Acierto 

(08-NOV-2007, DP Number 343466).

II. Residue Information 
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Flonicamid Use:

Flonicamid is a Group 9C insecticide (selective feeding blocker) registered for the control of a 

variety of aphid pests and the suppression of a variety of non-aphid pests. Tolerances for 

registered commodities can be found in 40 CFR§180.613. The tolerances that are currently

being recommended are listed in Table 1, below. The residues of concern in/on plants are the 

parent flonicamid and its major metabolites, TFNA-AM, TFNA, and TFNG; and in/on ruminants 

are the parent and its metabolites TFNA-AM and TFNA. 

Residue Data used for Chronic Assessments:

The residue levels used in the chronic assessment were the tolerance levels for plant 

commodities established under 40 CFR §180.613 and the HED recommended tolerance levels 

based on the crop field trials for the proposed crops. The livestock commodity tolerances are 

unchanged from the previous assessment. Table 1 presents a summary of the tolerance residue 

levels used in the chronic assessment.

Estimated concentrations of flonicamid in drinking water from the proposed uses were provided 

by EFED and incorporated directly into the chronic assessment. 

The assessments used 100% crop treated.

Table 1. Tolerance Summary for Proposed Uses of Flonicamid

Commodity Proposed Tolerance 

(ppm)

HED 

Recommended 

Tolerance 

(ppm)

Comments 

(correct commodity 

definition)

Berry, low growing, subgroup 13-07G 1.4 1.5

Rapeseed subgroup 20A 1.5 1.5

Vegetable, cucurbit, group 9 0.4 1.5 Vegetable, cucurbit, 

group 9

Processing Factors:

Separate tolerances were established for dried potatoes, tomato paste, and tomato puree based on 

processing studies. The processing factor was set to 1.0 for these commodities. DEEM default 

processing factors were used for the other processed commodities for which default processing 

factors are available.

III. Drinking Water

The drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED) in the following memorandum: “Drinking 

Water Assessment to Assess Flonicamid Use on Low Growing Berries Subgroup 13-07G, 

Greenhouse Cucumbers, and Rapeseed 20A” (J. Hetrick, D396906, 4/25/12). Water residues 

were incorporated in the DEEM-FCID into the food categories “water, direct, all sources” and 
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“water, indirect, all sources.” 

No monitoring data of flonicamid were available to EFED. The estimated drinking water 

concentrations from surface water sources were calculated using the Tier II PRZM (Pesticide 

Root Zone Model) and EXAMS (Exposure Analysis Modeling System). PRZM is used to 

simulate pesticide transport as a result of runoff and erosion from an agricultural field and 

EXAMS estimates environmental fate and transport of pesticides in surface water. The values 

generated by the models for drinking water were multiplied by a national crop area factor (PCA), 

which accounts for the fact that it is unlikely for any basin to be completely planted to 

agricultural crops. Ground water concentrations were estimated using the Tier I SCI-GROW 

Model. The model and its description are available at the EPA internet site: 

http://www.epa.gov/oppefed1/models/water/. Flonicamid may be applied by aerial, ground, or 

chemigation as per the labels for this product. This memo only addresses the estimations of 

parent flonicamid and its major metabolites, TFNG, TFNA, TFNA-OH, TFNA-AM, and TFNGAM. 

Based on modeling results, the estimated concentration of flonicamid and its degradation 

products is 1.9 μg /L (ppb) for the 1 in 10 year annual mean concentration (non-cancer chronic).

This estimate is based on three aerial applications at the rate of 0.089 lb ai/acre to potatoes in 

Maine using a PCA factor of 0.87.

Both the acute and chronic estimated concentrations for flonicamid in ground water using the 

SCIGROW (version 2.3) Model are 1.32 x 10-3μg/L (ppb) for the combined residues. 

The surface water value of 1.9 ppb was used in the dietary assessment because the surface water 

estimate is greater than the ground water estimate.

IV. DEEM-FCIDTM Program and Consumption Information

Flonicamid chronic dietary exposure assessment was conducted using the Dietary Exposure 

Evaluation Model software with the Food Commodity Intake Database DEEM-FCID, Version 

3.16, which incorporates consumption data from USDA’s NHANES/WWEIA. This dietary

survey was conducted from 2003 to 2008. The data are based on the reported consumption of 

more than 20,000 individuals over two non-consecutive survey days. Foods “as consumed” 

(e.g., apple pie) are linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; 

fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe 

translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, 

consumption data are averaged for the entire U.S. population and within population subgroups, 

but for acute exposure assessment are retained as individual consumption events. Based on 

analysis of the 1994-96, 98 CSFII consumption data, which took into account dietary patterns 

and survey respondents, HED concluded that it is most appropriate to report risk for the 

following population subgroups: the general U.S. population, all infants (<1 year old), children 

1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years 

old.
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For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup.

V. Toxicological Information

The toxicity database for flonicamid was evaluated by HED's Toxicology Team on 9/30/2004. 

The team selected endpoints and evaluated for FQPA concerns based on the potential hazard and 

exposure data for flonicamid and determined that there was no need for an additional safety 

factor for the protection of infants and children. Flonicamid is classified to be category

“Suggestive Evidence of Carcinogenicity, but Not Sufficient to Assess Human Carcinogenic 

Potential,” according to the EPA Draft Guidelines for Carcinogen Risk Assessment dated July, 

1999; therefore, a cancer assessment is not necessary. HED’s current toxicology team has 

reevaluated the endpoints and determined they are acceptable and applicable for risk assessment 

purposes.

Table 2. Summary of Dose and Toxicological Endpoint Selection Relative to Use in Dietary Human Health Risk 

Assessment for Flonicamid

Exposure

Scenario

Dose (mg/kg/day) 

UF

FQPA Safety Factor and 

Level of Concern for 

Risk Assessment

Endpoint for Risk Assessment

Acute Dietary

general population 

including infants and 

children

N/A N/A N/A

Chronic Dietary

(All populations)

NOAEL= 4.0 mg/kg/day 

UF = 100 

cPAD = 0.04 mg/kg/day

FQPA SF = 1x

cPAD = Chronic RfD

 FQPA SF

 = 0.04 mg/kg/day

2-Gen reproduction study in the 

rat. Parental LOAEL = 22 

mg/kg/day based on increased 

kidney weights, kidney hyaline 

deposition, increased blood serum 

LH (F1 females). 

Cancer (oral, dermal, 

inhalation)

Classified as "Suggestive 

Evidence of 

Carcinogenicity, but Not 

Sufficient to Assess 

Human Carcinogenic 

Potential"

N/A N/A

UF = uncertainty factor, FQPA SF = Special FQPA safety factor, NOEL = no observed adverse effect level, LOAEL 

= lowest observed adverse effect level, cPAD = chronic population, adjusted dose, Rfd = reference dose, N/A = not 

applicable.

VI. Results/Discussion
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As stated above, for chronic assessments, HED is concerned when dietary risk exceeds 100% of 

the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the U.S. population and 

various population subgroups. The results reported in Table 3 below are for the general U.S. 

Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, 

females 13-49, adults 20-49, and adults 50+ years. 

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis

The results of the chronic dietary (food and drinking water) exposure analysis are reported in 

Table 3 below. 

The chronic dietary (food and drinking water) exposure to flonicamid is below HED’s level of 

concern for the general U.S. population and all population subgroups. The chronic dietary

exposure estimates are 11% cPAD for the general U.S. population and 25% cPAD for children 1-

2 years old, the most highly exposed population subgroup.

Table 3. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Flonicamid1

Population Subgroup

cPAD 

(mg/kg/day)

Exposure (mg/kg/day) % cPAD

DEEM-FCID DEEM-FCID

General U.S. Population

0.04

0.004455 11

All Infants (< 1 year old) 0.006272 16

Children 1-2 years old 0.011236 28

Children 3-5 years old 0.008413 21

Children 6-12 years old 0.004999 11

Youth 13-19 years old 0.003184 8

Adults 20-49 years old 0.003864 10

Females 13-49 years old 0.003962 10

Adults 50-99 years old 0.004270 11

1 The population with the highest exposure is in bold

VII. Characterization of Inputs/Outputs

The chronic dietary exposure analysis is considered to be conservative. As a result, HED is 

confident that exposure is not underestimated to the U.S. population or any population subgroup. 

Further refinements could be made; however, they are not necessary at the present time.

VIII. Conclusions

The chronic dietary exposure assessment was conducted for the proposed uses on greenhouse 

cucumber, low growing berries, rapeseed, and drinking water. A conservative assessment was 

conducted using tolerance residue values and 100% crop treated. Estimated concentrations of 

flonicamid in drinking water from the proposed uses were provided by EFED and incorporated 
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directly into the chronic assessments. 

The chronic dietary (food and drinking water) exposure to flonicamid is below HED’s level of 

concern for the general U.S. population and all population subgroups. The chronic dietary

exposure estimates are 11% cPAD for the general U.S. population and 28% cPAD for children 1-

2 years old, the most highly exposed population subgroup.

IX. List of Attachments

Attachment 1: Chronic Food and Water Residue Input File.

Attachment 2: Chronic Results File.
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ATTACHMENT 1. DEEM-FCID CHRONIC RESIDUE INPUT FILE.

Filename: C:\Documents and Settings\cwalls\My 

Documents\Cassi\HED\Flonicamid\FLONICAMID050712.R08

Chemical: FLONICAMID

RfD(Chronic): .04 mg/kg bw/day NOEL(Chronic): 4 mg/kg bw/day

RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 08-23-2012/09:49:14 Program ver. 3.16, 03-08-d

Comment: CHRONIC ONLY

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101050000 1AB Beet, garden, roots 0.600000 1.000 1.000 

0101050001 1AB Beet, garden, roots-babyfood 0.600000 1.000 1.000 

0101067000 1AB Burdock 0.600000 1.000 1.000 

0101078000 1AB Carrot 0.600000 1.000 1.000 

0101078001 1AB Carrot-babyfood 0.600000 1.000 1.000 

0101079000 1AB Carrot, juice 0.600000 1.000 1.000 

0101084000 1AB Celeriac 0.600000 1.000 1.000 

0101100000 1AB Chicory, roots 0.600000 1.000 1.000 

0101168000 1AB Ginseng, dried 0.600000 1.000 1.000 

0101190000 1AB Horseradish 0.600000 1.000 1.000 

0101250000 1AB Parsley, turnip rooted 0.600000 1.000 1.000 

0101251000 1AB Parsnip 0.600000 1.000 1.000 

0101251001 1AB Parsnip-babyfood 0.600000 1.000 1.000 

0101314000 1AB Radish, roots 0.600000 1.000 1.000 

0101316000 1AB Radish, Oriental, roots 0.600000 1.000 1.000 

0101327000 1AB Rutabaga 0.600000 1.000 1.000 

0101331000 1AB Salsify, roots 0.600000 1.000 1.000 

0101388000 1AB Turnip, roots 0.600000 1.000 1.000 

0103015000 1CD Arrowroot, flour 0.200000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 0.200000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 0.200000 1.000 1.000 

0103082000 1CD Cassava 0.200000 1.000 1.000 

0103082001 1CD Cassava-babyfood 0.200000 1.000 1.000 

0103139000 1CD Dasheen, corm 0.200000 1.000 1.000 

0103166000 1CD Ginger 0.200000 1.000 1.000 

0103166001 1CD Ginger-babyfood 0.200000 1.000 1.000 

0103167000 1CD Ginger, dried 0.200000 1.000 1.000 

0103296000 1C Potato, chips 0.200000 1.000 1.000 

0103297000 1C Potato, dry (granules/ flakes) 0.400000 1.000 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 0.400000 1.000 1.000 

0103298000 1C Potato, flour 0.400000 1.000 1.000 

0103298001 1C Potato, flour-babyfood 0.400000 1.000 1.000 

0103299000 1C Potato, tuber, w/peel 0.200000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.200000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.200000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.200000 1.000 1.000 

0103366000 1CD Sweet potato 0.200000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.200000 1.000 1.000 

0103371000 1CD Tanier, corm 0.200000 1.000 1.000 

0103387000 1CD Turmeric 0.200000 1.000 1.000 

0103406000 1CD Yam, true 0.200000 1.000 1.000 

0103407000 1CD Yam bean 0.200000 1.000 1.000 

0200315000 2 Radish, tops 16.000000 1.000 1.000 

0401005000 4A Amaranth, leafy 4.000000 1.000 1.000 

0401018000 4A Arugula 4.000000 1.000 1.000 

0401104000 4A Chrysanthemum, garland 4.000000 1.000 1.000 

0401133000 4A Cress, garden 4.000000 1.000 1.000 

0401134000 4A Cress, upland 4.000000 1.000 1.000 
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0401138000 4A Dandelion, leaves 4.000000 1.000 1.000 

0401150000 4A Endive 4.000000 1.000 1.000 

0401204000 4A Lettuce, head 4.000000 1.000 1.000 

0401205000 4A Lettuce, leaf 4.000000 1.000 1.000 

0401248000 4A Parsley, leaves 4.000000 1.000 1.000 

0401313000 4A Radicchio 4.000000 1.000 1.000 

0401355000 4A Spinach 9.000000 1.000 1.000 

0401355001 4A Spinach-babyfood 9.000000 1.000 1.000 

0402076000 4B Cardoon 4.000000 1.000 1.000 

0402085000 4B Celery 4.000000 1.000 1.000 

0402085001 4B Celery-babyfood 4.000000 1.000 1.000 

0402086000 4B Celery, juice 4.000000 1.000 1.000 

0402087000 4B Celtuce 4.000000 1.000 1.000 

0402152000 4B Fennel, Florence 4.000000 1.000 1.000 

0402322000 4B Rhubarb 4.000000 1.000 1.000 

0402367000 4B Swiss chard 4.000000 1.000 1.000 

0501061000 5A Broccoli 1.500000 1.000 1.000 

0501061001 5A Broccoli-babyfood 1.500000 1.000 1.000 

0501062000 5A Broccoli, Chinese 1.500000 1.000 1.000 

0501064000 5A Brussels sprouts 1.500000 1.000 1.000 

0501069000 5A Cabbage 1.500000 1.000 1.000 

0501071000 5A Cabbage, Chinese, napa 1.500000 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 1.500000 1.000 1.000 

0501083000 5A Cauliflower 1.500000 1.000 1.000 

0501196000 5A Kohlrabi 1.500000 1.000 1.000 

0502063000 5B Broccoli raab 16.000000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 16.000000 1.000 1.000 

0502117000 5B Collards 16.000000 1.000 1.000 

0502194000 5B Kale 16.000000 1.000 1.000 

0502229000 5B Mustard greens 16.000000 1.000 1.000 

0502318000 5B Rape greens 16.000000 1.000 1.000 

0502389000 5B Turnip, greens 16.000000 1.000 1.000 

0801374000 8A Tomatillo 0.400000 1.000 1.000 

0801375000 8A Tomato 0.400000 1.000 1.000 

0801375001 8A Tomato-babyfood 0.400000 1.000 1.000 

0801376000 8A Tomato, paste 2.000000 1.000 1.000 

0801376001 8A Tomato, paste-babyfood 2.000000 1.000 1.000 

0801377000 8A Tomato, puree 0.500000 1.000 1.000 

0801377001 8A Tomato, puree-babyfood 0.500000 1.000 1.000 

0801378000 8A Tomato, dried 0.400000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 0.400000 14.300 1.000 

0801379000 8A Tomato, juice 0.400000 1.500 1.000 

0802148000 8BC Eggplant 0.400000 1.000 1.000 

0802234000 8BC Okra 0.400000 1.000 1.000 

0802270000 8B Pepper, bell 0.400000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 0.400000 1.000 1.000 

0802271000 8B Pepper, bell, dried 0.400000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 0.400000 1.000 1.000 

0802272000 8BC Pepper, nonbell 0.400000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 0.400000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 0.400000 1.000 1.000 

0901075000 9A Cantaloupe 1.500000 1.000 1.000 

0901187000 9A Honeydew melon 1.500000 1.000 1.000 

0901399000 9A Watermelon 1.500000 1.000 1.000 

0901400000 9A Watermelon, juice 1.500000 1.000 1.000 

0902021000 9B Balsam pear 1.500000 1.000 1.000 

0902088000 9B Chayote, fruit 1.500000 1.000 1.000 

0902102000 9B Chinese waxgourd 1.500000 1.000 1.000 

0902135000 9B Cucumber 1.500000 1.000 1.000 

0902308000 9B Pumpkin 1.500000 1.000 1.000 

0902309000 9B Pumpkin, seed 1.500000 1.000 1.000 

0902356000 9B Squash, summer 1.500000 1.000 1.000 
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0902356001 9B Squash, summer-babyfood 1.500000 1.000 1.000 

0902357000 9B Squash, winter 1.500000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 1.500000 1.000 1.000 

1100007000 11 Apple, fruit with peel 0.200000 1.000 1.000 

1100008000 11 Apple, peeled fruit 0.200000 1.000 1.000 

1100008001 11 Apple, peeled fruit-babyfood 0.200000 1.000 1.000 

1100009000 11 Apple, dried 0.200000 8.000 1.000 

1100009001 11 Apple, dried-babyfood 0.200000 8.000 1.000 

1100010000 11 Apple, juice 0.200000 1.300 1.000 

1100010001 11 Apple, juice-babyfood 0.200000 1.300 1.000 

1100011000 11 Apple, sauce 0.200000 1.000 1.000 

1100011001 11 Apple, sauce-babyfood 0.200000 1.000 1.000 

1100129000 11 Crabapple 0.200000 1.000 1.000 

1100210000 11 Loquat 0.200000 1.000 1.000 

1100266000 11 Pear 0.200000 1.000 1.000 

1100266001 11 Pear-babyfood 0.200000 1.000 1.000 

1100267000 11 Pear, dried 0.200000 6.250 1.000 

1100268000 11 Pear, juice 0.200000 1.000 1.000 

1100268001 11 Pear, juice-babyfood 0.200000 1.000 1.000 

1100310000 11 Quince 0.200000 1.000 1.000 

1201090000 12A Cherry 0.600000 1.000 1.000 

1201090001 12A Cherry-babyfood 0.600000 1.000 1.000 

1201091000 12A Cherry, juice 0.600000 1.500 1.000 

1201091001 12A Cherry, juice-babyfood 0.600000 1.500 1.000 

1202012000 12B Apricot 0.600000 1.000 1.000 

1202012001 12B Apricot-babyfood 0.600000 1.000 1.000 

1202013000 12B Apricot, dried 0.600000 6.000 1.000 

1202014000 12B Apricot, juice 0.600000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 0.600000 1.000 1.000 

1202230000 12B Nectarine 0.600000 1.000 1.000 

1202260000 12B Peach 0.600000 1.000 1.000 

1202260001 12B Peach-babyfood 0.600000 1.000 1.000 

1202261000 12B Peach, dried 0.600000 7.000 1.000 

1202261001 12B Peach, dried-babyfood 0.600000 7.000 1.000 

1202262000 12B Peach, juice 0.600000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 0.600000 1.000 1.000 

1203285000 12C Plum 0.600000 1.000 1.000 

1203285001 12C Plum-babyfood 0.600000 1.000 1.000 

1203286000 12C Plum, prune, fresh 0.600000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 0.600000 1.000 1.000 

1203287000 12C Plum, prune, dried 0.600000 5.000 1.000 

1203287001 12C Plum, prune, dried-babyfood 0.600000 5.000 1.000 

1203288000 12C Plum, prune, juice 0.600000 1.400 1.000 

1203288001 12C Plum, prune, juice-babyfood 0.600000 1.400 1.000 

1307130000 13G Cranberry 1.500000 1.000 1.000 

1307130001 13G Cranberry-babyfood 1.500000 1.000 1.000 

1307131000 13G Cranberry, dried 1.500000 1.000 1.000 

1307132000 13G Cranberry, juice 1.500000 1.100 1.000 

1307132001 13G Cranberry, juice-babyfood 1.500000 1.100 1.000 

1307359000 13G Strawberry 1.500000 1.000 1.000 

1307359001 13G Strawberry-babyfood 1.500000 1.000 1.000 

1307360000 13G Strawberry, juice 1.500000 1.000 1.000 

1307360001 13G Strawberry, juice-babyfood 1.500000 1.000 1.000 

2001163000 20A Flax seed, oil 1.500000 1.000 1.000 

2001319000 20A Rapeseed, oil 1.500000 1.000 1.000 

2001319001 20A Rapeseed, oil-babyfood 1.500000 1.000 1.000 

2001336000 20A Sesame, seed 1.500000 1.000 1.000 

2001336001 20A Sesame, seed-babyfood 1.500000 1.000 1.000 

2001337000 20A Sesame, oil 1.500000 1.000 1.000 

2001337001 20A Sesame, oil-babyfood 1.500000 1.000 1.000 

2003128000 20C Cottonseed, oil 0.500000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 0.500000 1.000 1.000 
Flonicamid Dietary Exposure Assessment DP Barcode: D397279

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3100044000 31 Beef, meat 0.080000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.080000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.080000 1.920 1.000 

3100046000 31 Beef, meat byproducts 0.080000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.080000 1.000 1.000 

3100047000 31 Beef, fat 0.030000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.030000 1.000 1.000 

3100048000 31 Beef, kidney 0.080000 1.000 1.000 

3100049000 31 Beef, liver 0.080000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 0.080000 1.000 1.000 

3200169000 32 Goat, meat 0.080000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.080000 1.000 1.000 

3200171000 32 Goat, fat 0.030000 1.000 1.000 

3200172000 32 Goat, kidney 0.080000 1.000 1.000 

3200173000 32 Goat, liver 0.080000 1.000 1.000 

3300189000 33 Horse, meat 0.080000 1.000 1.000 

3500339000 35 Sheep, meat 0.080000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.080000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.080000 1.000 1.000 

3500341000 35 Sheep, fat 0.030000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.030000 1.000 1.000 

3500342000 35 Sheep, kidney 0.080000 1.000 1.000 

3500343000 35 Sheep, liver 0.080000 1.000 1.000 

3600222000 36 Milk, fat 0.030000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.030000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.030000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.030000 1.000 1.000 

3600224000 36 Milk, water 0.030000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.030000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.030000 1.000 1.000 

4000093000 40 Chicken, meat 0.030000 1.000 1.000 

4000093001 40 Chicken, meat-babyfood 0.030000 1.000 1.000 

4000094000 40 Chicken, liver 0.030000 1.000 1.000 

4000095000 40 Chicken, meat byproducts 0.030000 1.000 1.000 

4000095001 40 Chicken, meat byproducts-babyfoo 0.030000 1.000 1.000 

4000096000 40 Chicken, fat 0.030000 1.000 1.000 

4000096001 40 Chicken, fat-babyfood 0.030000 1.000 1.000 

4000097000 40 Chicken, skin 0.030000 1.000 1.000 

4000097001 40 Chicken, skin-babyfood 0.030000 1.000 1.000 

5000382000 50 Turkey, meat 0.030000 1.000 1.000 

5000382001 50 Turkey, meat-babyfood 0.030000 1.000 1.000 

5000383000 50 Turkey, liver 0.030000 1.000 1.000 

5000383001 50 Turkey, liver-babyfood 0.030000 1.000 1.000 

5000384000 50 Turkey, meat byproducts 0.030000 1.000 1.000 

5000384001 50 Turkey, meat byproducts-babyfood 0.030000 1.000 1.000 

5000385000 50 Turkey, fat 0.030000 1.000 1.000 

5000385001 50 Turkey, fat-babyfood 0.030000 1.000 1.000 

5000386000 50 Turkey, skin 0.030000 1.000 1.000 

5000386001 50 Turkey, skin-babyfood 0.030000 1.000 1.000 

6000301000 60 Poultry, other, meat 0.030000 1.000 1.000 

6000302000 60 Poultry, other, liver 0.030000 1.000 1.000 

6000303000 60 Poultry, other, meat byproducts 0.030000 1.000 1.000 

6000304000 60 Poultry, other, fat 0.030000 1.000 1.000 

6000305000 60 Poultry, other, skin 0.030000 1.000 1.000 

7000145000 70 Egg, whole 0.040000 1.000 1.000 

7000145001 70 Egg, whole-babyfood 0.040000 1.000 1.000 

7000146000 70 Egg, white 0.040000 1.000 1.000 

7000146001 70 Egg, white (solids)-babyfood 0.040000 1.000 1.000 

7000147000 70 Egg, yolk 0.040000 1.000 1.000 

7000147001 70 Egg, yolk-babyfood 0.040000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.001900 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.001900 1.000 1.000 
Flonicamid Dietary Exposure Assessment DP Barcode: D397279

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9500188000 O Hop 7.000000 1.000 1.000 
Flonicamid Dietary Exposure Assessment DP Barcode: D397279

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Attachment 2: DEEM-FCID Chronic Results

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for FLONICAMID NHANES 2003-2008 2-day

Residue file name: C:\Documents and Settings\cwalls\My 

Documents\Cassi\HED\Flonicamid\FLONICAMID050712.R08

 Adjustment factor #2 NOT used.

Analysis Date 09-27-2012/15:13:35 Residue file dated: 09-27-2012/15:12:49

Reference dose (RfD, Chronic) = .04 mg/kg bw/day

COMMENT 1: CHRONIC ONLY

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.004455 11.1%

Hispanic 0.004094 10.2%

Non-Hisp-White 0.004421 11.1%

Non-Hisp-Black 0.004612 11.5%

Non-Hisp-Other 0.005475 13.7%

Nursing Infants 0.004389 11.0%

Non-Nursing Infants 0.007113 17.8%

Female 13+ PREG 0.004172 10.4%

Children 1-6 0.009134 22.8%

Children 7-12 0.004695 11.7%

Male 13-19 0.003124 7.8%

Female 13-19/NP 0.003246 8.1%

Male 20+ 0.003698 9.2%

Female 20+/NP 0.004334 10.8%

Seniors 55+ 0.004270 10.7%

All Infants 0.006272 15.7%

Female 13-50 0.003950 9.9%

Children 1-2 0.011236 28.1%

Children 3-5 0.008413 21.0%

Children 6-12 0.004999 12.5%

Youth 13-19 0.003184 8.0%

Adults 20-49 0.003864 9.7%

Adults 50-99 0.004270 10.7%

Female 13-49 0.003962 9.9%

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