UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D

.C

. 20460 

## JUL 20 2015

MEMORANDUM OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION

SUBJECT: 

### BEAD Chemical Profile (BCP) for Registration Review: Antimycin A (006314) FROM:

THRU: 

### Carl Chen, Plant Pathologist

·Biological Analysis Branch Donald Atwood, Entomologist Science Information and Analysis Branch**~ ~~**  

### Derek Berwald, Economist

# ~**~ ~**  Michelle Ranville, Economist Economic Analysis Branch Biological and Economic Analysis Division (7503P) .-.-

### ~J//'L

## :_**~I'** 

## ;J,.,._e.r::,J,,,..e**~** Arnet Jones, Chief 

### Biological Analysis**Bran ~**  

### Diann Sims, Chief 

# M

. Science Information and Analysis Branch Timothy Kiely, Chief 

# m 011Ao

# }vu**~** 

# · fl.x'**Tim~** 

# ILt.t

# u...,**Econom~c** Analysis Branch J 

### Biological and Economic Analysis Division (7503P) TO: Eric Miederhoff, Chemical Review Manager Risk Management and Implementation Branch 1 Pesticide Re-evaluation Division (7508P)

Product Review Panel date: July 8, 2015

The Biological and Economic Analysis Division (BEAD) Chemical Profile (BCP) provides an overview ofthe pest management role and quantitative usage information available for a pesticide. Information provided inthis BCP may be used by stakeholders (e.g., users and Page 1registrants), Office ofPesticide Programs (OPP) risk and benefit assessors, OPP risk managers, and the general public during the Registration Review process ofantimycin A. Antimycin A was registered in the United States in 1960. Its use sites include aquaculture, lakes, ponds, streams, channels, and intermittently flooded areas. Ithas only one end-use product, Fintrol® Fish Toxicant Kit, formulated as a soluble concentrate and registered under Section 3 of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). Water treatment is made when needed through spray equipment, boatbailer, ordrip stations. Antimycin A is registered for control ofunwanted fish as a fish toxicant. Itkills by interfering with the respiration ofbody cells with a complete kill at high concentrations to eliminate all fish or a selective kill at lower concentrations to eliminate only smaller ormore sensitive species. Approximately 20 fish species or groups are listed onthe label that include carp, trash fish, catfish, freshwater drum, and suckers. BEAD'sprevious work on antimycin A has included an alternatives analysis as part ofthe risk mitigation and reregistrationprocess and an evaluation for a lowvolume minor use data waiver request (Kaul et al., 2006; Kaul, 2007; Donaldson, 2009). BEAD's findings include: 1) there are only two registered broad spectrum piscicides, antimycin A and rotenone; 2) there are insufficient efficacious alternatives and antimycin A has niche uses so that it is useful for endangered fish repopulation efforts; and 3) it is a minor use as defined by FIFRA Section 2(ll) and there is limited economic incentive to produce requested data in order to continue its registration. There have been no BEADbenefits assessments or BEAD assessments for FIFRA Section 18 emergency exemption requests for antimycin A in the last 10 years. While an emergency exemptionrequest may yield information about a chemical's importance, the lack ofa FIFRA Section 18 assessment by BEAD is not anindicator ofthe relative importance ofthe chemical. Quantitative usage information for antimycin A is not available. In the event more information is needed concerning its use·or importance during registration review, the following maybe requested: 1) total pounds ofactive ingredient applied per year on a national and/orregional basis; 2) acreage orpercent area treated; 3) applicationrates: typical and maximum; 4) frequency and intervals ofapplication; and 5) efficacy information/product performance. REFERENCES Donaldson D. 2009. Evaluation ofBEAD related aspects ofthe low volume minor use data waiver request for antimycin A. EPA OPP Biological and Economic Analysis Division. Kaul M, ZinnN, Faulkner J. 2006. Alternatives analysis for antimycin A androtenone in lakes and streams. EPA OPP Biological and Economic Analysis Division. Kaul M. 2007. Response to public comments on alternatives analysis for antimycin A in lakes and streams. EPA OPP Biological and Economic Analysis Division.

Page2