Federal Register / Vol. 72, No. 166 / Tuesday, August 28, 2007 / Notices 49289 

form of identification (for example, a 

government-issued photo ID, driver’s license, 

or passport) and to state the purpose of their 

visit. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.879, Medical Library 

Assisance, National Institutes of Health, 

HHS) 

Dated: August 22, 2007. 

Jennifer Spaeth, 

Director, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 07–4215 Filed 8–27–07; 8:45 am] 

BILLING CODE 4140–01–M 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Library of Medicine; Notice of 

Closed Meetings 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. Appendix 2), notice 

is hereby given of the following 

meetings. 

The meetings will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: National Library of 

Medicine Special Emphasis Panel; G08–R01–

R21. 

Date: October 15, 2007. 

Time: 1 p.m. to 4:30 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Library of Medicine, 6705 

Rockledge Drive, Suite 301, Bethesda, MD 

20817 (Telephone Conference Call). 

Contact Person: Zoe E. Huang, MD, Health 

Scientific Administrator, Extramural 

Programs, National Library of Medicine, 

Rockledge 1 Building, 6705 Rockledge Drive, 

Suite 301, Bethesda, MD 20892–7968, 301–

594–4937, huangz@mail.nih.gov. 

Name of Committee: Biomedical Library 

and Informatics Review Committee. 

Date: November 6–7, 2007. 

Time: November 6, 2007, 8 a.m. to 6 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Library of Medicine, 

Building 38, 2nd Floor, Board Room, 9000 

Rockville Pike, Bethesda, MD 20894. 

Time: November 7, 2007, 8 a.m. to 2 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Library of Medicine, 

Building 38, 2nd Floor, Board Room, 9000 

Rockville Pike, Bethesda, MD 20894. 

Contact Person: Arthur A. Petrosian, PhD, 

Scientific Review Administrator, Division of 

Extramural Programs, National Library of 

Medicine, 6705 Rockledge Drive, Suite 301, 

Bethesda, MD 20892–7968, 301–496–4253, 

petrosia@mail.nih.gov. 

Any interested person may file written 

comments with the committee by forwarding 

the statement to the contact Person listed on 

this notice. The statement should include the 

name, address, telephone number and when 

applicable, the business or professional 

affiliation of the interested person. 

In the interest of security, NIH has 

instituted stringent procedures for entrance 

onto the NIH campus. All visitor vehicles, 

including taxicabs. hotel, and airport shuttles 

will be inspected before being allowed on 

campus. Visitors will be asked to show one 

form of identification (for example, a 

government-issued photo ID, driver’s license, 

or passport) and to state the purpose of their 

visit. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.879, Medical Library 

Assistance, National Institutes of Health, 

HHS) 

Dated: August 22, 2007. 

Jennifer Spaeth, 

Director, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 07–4223 Filed 8–27–07; 8:45 am] 

BILLING CODE 4140–01–M 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Prospective Grant of Exclusive 

License: FDA Cleared Pediatric Cancer 

Diagnostics and Prognostics 

AGENCY: National Institutes of Health, 

Public Health Service, HHS. 

ACTION: Notice. 

SUMMARY: This is notice, in accordance 

with 35 U.S.C. 209(c)(1) and 37 CFR 

404.7(a)(1)(I), that the National 

Institutes of Health (NIH), Department 

of Health and Human Services, is 

contemplating the grant of an exclusive 

license to practice the invention 

embodied in Patent Applications U.S. 

10/133,937, filed 04/25/2002, entitled 

‘‘Methods for Analyzing High 

Dimensional Data for Classifying, 

Diagnosing, Prognosticating and/or 

Predicting Diseases and Other Biological 

States’’; and U.S. 10/159,563, filed 05/ 

31/2002, entitled ‘‘Selections of Genes 

And Methods of Using The Same For 

Diagnosis And For Targeting The 

Therapy of Select Cancers’’; to Althea 

Technologies, Inc. having a place of 

business in San Diego, California. The 

patent rights in this invention have been 

assigned to the United States of America 

(PHS ref E–324–2001/0,1). 

DATE: Only written comments and/or 

application for a license that are 

received by the NIH Office of 

Technology Transfer on or before 

October 29, 2007 will be considered. 

ADDRESS: Requests for a copy of the 

patent application, inquiries, comments 

and other materials relating to the 

contemplated license should be directed 

to: Cristina Thalhammer-Reyero, Ph.D., 

M.B.A., Office of Technology Transfer, 

National Institutes of Health, 6011 

Executive Boulevard, Suite 325, 

Rockville, MD 20852–3804; e-mail: 

ThalhamC@mail.nih.gov; Telephone: 

301–435–4507; Facsimile: 301–402–

0220. 

SUPPLEMENTARY INFORMATION: The 

prospective exclusive license will be 

royalty bearing and will comply with 

the terms and conditions of 35 U.S.C. 

209 and 37 CFR 404.7. The prospective 

exclusive license may be granted unless, 

within 60 days from the date of this 

published Notice, NIH receives written 

evidence and argument that establishes 

that the grant of the license would not 

be consistent with the requirements of 

35 U.S.C. 209 and 37 CFR 404.7. 

The invention relates to a method of 

using supervised pattern recognition 

methods for classifying, diagnosing, 

predicting, or prognosticating various 

diseases. The method includes 

obtaining high dimensional 

experimental data, such as gene 

expression profiling data, filtering the 

data, reducing the dimensionality of the 

data through use of one or more 

methods, training artificial neural 

networks (ANN, a supervised pattern 

recognition method), ranking individual 

data points from the data, choosing 

multiple data points from the data based 

on the relative ranking, and using the 

multiple data points to determine if an 

unknown set of experimental data 

indicates a diseased condition, a 

predilection for a diseased condition, or 

a prognosis about a diseased condition. 

Further, the invention relates to sets of 

genes expressed in cancer cells that 

function to characterize each cancer 

type, and methods of using the sets of 

genes for diagnosis and for targeting the 

therapy of selected cancers. In 

particular, the methods apply to classify 

cancers which often present diagnostic 

dilemmas in clinical practice, such as 

the pediatric small round blue cell 

tumors (SRBCTs), including 

neuroblastoma (NB), 

rhabdomyosarcoma (RMS), Burkitt’s 

lymphoma (BL), and the Ewing family 

of tumors (EWS). Specifically, the 

invention is an application of ANNs for 


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