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                                                                   Exhibit 10.82

           THE SECURITIES REPRESENTED HEREBY HAVE BEEN ISSUED WITHOUT
           REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR
           UNDER ANY STATE SECURITIES LAWS, AND MAY NOT BE SOLD,
           TRANSFERRED OR PLEDGED IN THE ABSENCE OF AN EFFECTIVE
           REGISTRATION STATEMENT UNDER APPLICABLE FEDERAL AND STATE
           SECURITIES LAWS OR AN OPINION OF COUNSEL REASONABLY SATISFACTORY
           TO THE COMPANY THAT THE TRANSFER IS EXEMPT FROM REGISTRATION
           UNDER APPLICABLE FEDERAL AND STATE SECURITIES LAWS.

                         VYTERIS HOLDINGS (NEVADA), INC.
                         10% CONVERTIBLE PROMISSORY NOTE

$500,000                                                   Fair Lawn, New Jersey
                                                                  March 20, 2006

        FOR VALUE RECEIVED, the undersigned, Vyteris Holdings (Nevada), Inc., a
Nevada corporation (the "Issuer"), hereby unconditionally promises to pay, in
accordance with the Note Purchase Agreement (the "Note Purchase Agreement"),
dated as of the date hereof, by and between the Issuer and Spencer Trask
Specialty Group, LLC, a Delaware limited liability company (the "Purchaser"), on
the Maturity Date (as defined in the Note Purchase Agreement) to the order of
the Purchaser, at the office of the Purchaser located at 535 Madison Avenue, New
York, NY or such other address designated by the Purchaser, in lawful money of
the United States of America and in immediately available funds, the principal
amount of Five Hundred Thousand ($500,000) Dollars. The Issuer further agrees to
pay interest on the unpaid principal amount outstanding hereunder from time to
time from the date hereof in like money at the rates and as and on the dates
specified in Section 3.3 of the Note Purchase Agreement.

        This Note is the promissory note referred to in the Note Purchase
Agreement, and is entitled to the benefits thereof, and is subject to voluntary
and mandatory conversions as set forth therein. This Note, and all
representations, warranties, covenants and agreements contained herein and in
the Note Purchase Agreement, shall be binding upon Issuer and its successors and
permitted assigns and shall inure to the benefit of the Purchaser and its
successors and assigns. Issuer may not assign or delegate any of its duties or
obligations under this Note without the written consent of the Purchaser, which
shall not be unreasonably withheld.

        Upon the occurrence of any one or more of the Events of Default
specified in the Note Purchase Agreement, all amounts then remaining unpaid on
this Note shall become, or may be declared to be, immediately due and payable,
all as provided in the Note Purchase Agreement.

        All parties now and hereafter liable with respect to this Note, whether
maker, principal, surety, guarantor, endorser or otherwise, hereby waive
presentment, demand, protest and all other notices of any kind.

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        Subject to Sections 3.3 and 10.5 of the Note Purchase Agreement, the
Issuer agrees to pay all of the Purchaser's expenses, including reasonable
attorneys' costs and fees, incurred in collecting sums due under this Note.

        This Note shall be governed by, and construed and interpreted in
accordance with, the laws of the State of New York.

                                         VYTERIS HOLDINGS (NEVADA), INC.


                                         By: /s/ Timothy J. McIntyre
                                             Name: Timothy J. McIntyre
                                             Title: President & Chief Executive
                                                    Officer








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