Penoxsulam (I 19031 ) Dietary Exposure and Risk Assessment DP Number: 4290 I0 

### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON , D .C . 20460



### MEMORANDUM Date: December 4 , 2015 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION



### SUB J ECT : Penoxs ulam . Chronic Aggregate Dietary (Foo d and Drinking Water) Exposure and Ri sk Assessment fo r the Section 3 Registra ti o n on P o me Fruit , Sto ne Fruit , Olive , Pomegranate, and Fruit, Sma ll , Vine C limbing (Subgroup 13-07F, Except Fuzzy Ki w ifr uit); and Crop Group Convers ion for Tree N ut s. PC Code: 1190 3 I DP Barcode: D4290 I 0 Decision No.: 497353 Regi s tration No.: 62719-499 , 62719-611 Petition No.: 4E8330 Re gu latory Action: Section 3 Registration Risk Assessment Type: Single chemical , aggregate Case No.: NA TXR No.: NA CAS No.: 2 19714-96-2 MRJD No.: None 40 CFR: 180.605 

### FROM: Elizabeth Holman , Ph ysical**Scientist ~** **)+.,~** Ri sk Assess ment Branc h II 

### Health Effects Division (7509 P)**~** 

### THROUGH: Mohsen Sahafeyan, C hemi s; ·

# '~**~** \__

# 47f%**~/ ~**  Seyed Tadayon , C hemist

# ~~:;-_.. / Dietary Exposure Scie nc e Advi;?r'Y Co un cil (DES C) Health Effects Divisi o n (7509 P) 

### TO: Sidney Jack son/Barbara Madden Mi nor Use a nd Emergency Response Branch R eg istration Di vision (7505 P) 

### Executive Summary C hronic aggregate dietary [food and d rinking water] exposure and ri sk assessments were condu c t ed u s ing the Di etary E xpos w-e Evaluation Model softw are w ith th e Food Commod ity Intake D atabase ( DEEM

- FCID ) Version 3. 16. This softwa re uses 2003-2008 food consumption data from th e U.S. D epartment of Agriculture's (USDA's) Nat ional Health and Nutrit ion Exam ination Survey, What We Eat in America , (NHANES/WWEIA). The analysis was conducted in support of a human-health ri sk assessment for th e proposed Section 3 uses of penoxsulam on pome fru it, stone fru it , olive, pomegranate , a nd fr ui t. sma ll , v ine c limbin g Page I of I 0Penox sulam ( I 19031 ) Dietary Exposure and Risk A ss ess me n1 DP Number: 4290 I0 

### (S ubgroup l 3

- 07F, except 

### fuz zy kiwifruit) , plus crop group conversion for tree nut s. Specifically , crop gro up co nver s ions i nclu de the conversion of tree nut group 14 to tree nut group 14-12. In addition , the ex i sting tolerance on grape is being converted to a crop group tol e rance on fruit, small, vine climbing (S ub gro up 1 3

- 07F , exc ept fuz zy kiwifruit). T hi s memorandum was reviewed b y two peer re v iewers of the DESAC , p er DESAC SOP 2012.1. In calculatin g dietary risk estimates, HED ha s compared the chronic population adjusted dose (cPAD) to the respective estimated dietary exposures. Typically , HED has concerns regarding dietary risk w hen the estimates e xceed 100% of the cPAD. With the conse rvative ass umption s noted below , risk es timates ass oc iated with dietary exposure to penox s ulam a re signi fi cantly below HED 's level of concern. No s ingle dose effects w e re noted in th e toxicity stud ies for penox s ulam , so an acute dietary exposure and risk assessment was not required. Penox s ulam has been cl ass ified as having .. s ugge s tive evidence of carcinogenicity , but not sufficient to assess human carcinogenic potential. " As such, the chronic assessment is believed to be protective of potential carcinogenic effects; there fore, a separate cance r assessment was not required. An 

### unrefin e d chronic di e tary analysis for penoxsulam wa s conducted using tolerance le vel residues and 100% c rop-treated (CT) for all existing and proposed u ses . Default processing factors were used for all proce ssed commodities. Drinking water was incorporated directly into the dietary assess ment using the maximum est im ated chronic concentration associated with th e aquatic us e o f penoxsulam. The chronic risk estimates from di etary (foo d + drinking wate r) expos ure to penoxsulam do not exceed HED 's level of concern for the ge n eral U . S. population , or any of the population s ubgro ups. The chronic dietary risk estimate for the high est exposed population s ubgroup , all infants (< I year old) , is 6% of the cPAD. The gen eral U.S. populati on utili zes 2% o f the cPAD. I. 

### Introduction Dietary ri sk assessment incorp orate s both expos ure and toxicity of a given pesticide . For acute and chronic assessme nt s, the ri s k is ex pre ssed as a percentage of a maximum acceptable dose ( i.e. , the do se that HED has concluded will res ult in no unreasonable adverse health effec ts). Thi s dose i s referred to as the population-adjusted dose ( PAD). The PAD i s equiva lent to the point of departure (POD, NOA EL, LOAEL , e.g.) divided by the required uncertainty or safety factors. For acute and non-cancer chronic exposure s, HED is concerned when estimate d dietary risk exceeds 100% of the P AD . Referenc es that discu ss the acute and chronic ri s k asse ss ment s in more detail are available on the EPNpesticides web site: " Available Information on Assessing Exposure from Pe sticides, A Use r 's Guide ,' · 21

- JUN -2000 , web link: http ://www.regulations.gov/# !documentDetail;D = EPA-HQ-OPP-2007-0780-0001; or see SOP 99 .6 (20

- AUG

- 1999 ) . The most recent dietary risk assessment for pe nox s ulam was conducted by M. Doherty (03 / 24/2009 , 0360419 ). Page 2 o f 10Penox su lam ( 119031) Dietary Exposure and Risk Assessment DP Number: 429010 

### II. R es idue I nform a ti o n Tolerances for residue s of penoxsulam,per 

### se, [40 CFR 180.605] have been estab lished for fish (0.01 ppm) , crustaceans ( 0.0 l ppm), mollusks (0 .02 ppm), rice grain ( 0.02 ppm), and rice straw (0 .50 ppm), as well as 0.01 ppm in grape and tree nut ( in cludi n g pistach io) commodities. There are no tolerances established for meat, milk , or poultry commodit ies. Recommended Tolerances: As part of the current petition (4E8330) , under 40 CFR 180.605 (Tab le 1) , HED recommend s (E. Holman. DP4250 I 3, 12 /04/ 2015) for the to lerances of penoxsulam on pome fruit, s to ne fru it, olive, pomegranate , as well as crop group conversion for tree nuts and crop group expansion for fruit, small , vine climbing (Subgroup l 3-07F, except fuzzy kiwifruit).

T A BLE 1. Toler a n ce S umm ary fo r P e n oxs u l a m ( 40 CFR § 18 0. 60 5).

Propo sed or E xi s tin g* Propo se d o r Ex i s tin g* Re c omm e nd ed Co rr ect Commo dity D efi 11ition; Co mmo di ty To l erance ( ppm) To le ranc e loom) C omment s 4 0CFR § 18 0.S44l a llll Fruit , Pome, gro up 11-10 0.01 0.01 Fruit, pome, group I 1-10 Fruit , Stone. group 12-1 2 0.01 0.01 Fruit, s to n e, g roup 12-1 2 Fruit, small, vine 0.01 0.01 Based on available data on grape. climbing , subgroup 13- 07F, except fuzzy kiwifruit Nu t , Tree group 14-12 0.01 0.01 N111 , tree, group 1./-12; Conversion from tree nut group 14. Olive 0.01 0.01 Ba sed on submitted stone fruit and Pomegranate 0.01 0.01 pome fruit field trial data. Nut, tree , group 14 0.01 • Rem ove Conversion to tree nut group 14-1 2. Grape 0.01• Remove Replace with tolerance on Fruit, small, vine climbin g, sub g roup 13-07F, except fuzzy kiwifruit. Pi s tachio 0.01 • Remove Replace with the tolerance on tree nut group 14-1 2. • A tolerance is currently establ is hed at the listed tolerance level in the correspo ndin g commodity. 

### Residue Data Used for Chronic Assessment: Tolerance-level re s idue s were us ed for all e ntries in the assessment , except for fish , crustaceans , and mollusks , for which residue values include the 5-hydroxy metabolite of penoxsulam ; and it was assumed that all crops/foods with existing or proposed toleranc es were treated 

### (i. e . , 100% CT). The fish and shell fish express ion for risk assessment pu rposes is penoxsularn and its metabolite 5-0H penoxsu lam. To account for the presence of the metabolite , the parent tolerance is multiplied by a factor of l .4X (PP# 5F7012 , DP Nurn: 326985 , D . Soderberg , l/30/07 ). Therefore , the penoxsu lam re s idue level s for fish and crustacean is 0.014 ppm (0.01 ppm tolerance x 1.4 = 

### 0.0 14 ppm) a nd fo r mollusc is 0 .028 ppm (0.02 ppm toleranc e x 1.4 

## = 0.028 ppm). The available g rap e processing s tud y sho wed no concentration of penoxsulam residues upon processing. However , as there were no quantifiable residues of penoxsulam in either the grape raw agricu ltural commodity or the grape processed commodities , no empirical processi ng factors

Page 3of10Penoxsulam (I 1903 I) Dietary Expo sure and Ri sk Assessment DP Numb er: 4290 I0 could be calculated. In addition , ChemSAC previousl y concluded that as lon g as the field tri als s howed no quantifiable re s idues , addition a l processing stu di es are not re quire d to s upport penoxsulam tolerances on pom e fruit and s tone fruit (C hemSAC minutes, 09/ 0 1/ 20 l 0) . The avail abl e field trial data s howed no quantifi able res idues above the limit of quantita tion of 0.01 ppm for these commodities (E. Holman , D4 2 501 3, 12/ 04/2015) . Therefore, default proc ess ing facto rs from DEEM 7.81 were used for all processed co mm o ditie s of g rape , pome fruit , and stone fruit. Ill. Drinking Water D ata The Environmental Fate and Effects Division (EFED) has provide d HE D with Tier l m ode led estimate s of penoxsulam res idu es of co nc ern in drinking water based o n the proposed ne w u ses , as well as the ex istin g us e pattern (J. Wol f, 2 8 Aug 2015, D4 2 841 9). T he proposed new u ses re su lt in lower drinking water esti m ate s than tho se from the ex is tin g u se patt e rn. Based on the exi s ting turf g rass u se pattern (0 .09 lb a.i. / A) , residues of pe noxsu lam are not expected to be greater than 0.0463 ppm (Tab le 2) . Pe nox su lam is re g is tered for co ntrol of aquatic weeds. For that use pattern , the maximum app li cat ion rate i s 150 ppb (0.15 ppm) in the water column . Fo r t hi s assessment , HED ha s used 0 .15 ppm as a hi g h-end es timate of penoxsulam re s idue s in drinking water. The 0 . 15-ppm va lu e is like ly to be an overestimate of actual residu es in drinking wa t e r. Residues were incor porated in the DEEM-FC ID into the foo d categories "water , direct , all so urc es" and "water, indirect , all so urc es."

Table 2. S umm ary of Resid ue Esti mates for Penoxsu lam in Drinking Water. Turf Use Duration Aquatic Use, ppm S urface Water, ppm Ground Water, ppm Acute 0. 15 0.00154 0.0463 Chroni c 0. 15 0.000 11 0.0313 

### IV. DEEM-FCJDTM Program and Consumption Information The pen oxs ul am chronic d ietary ex pos ure assess ment was co ndu cted using the D E EM-FCID, Vers ion 3 .16 , w hich incorporates 2003-2008 con s umption d a ta fro m US DA 's N I IANES/ WWEIA. Th e d ata are based o n the reporte d consumption of more th an 20,000 indi v idu a ls over two non- con secuti ve survey days. Foods "as consumed" (e.g. , apple pie) are linked to EPA-defin e d food commodities (e . g., apples , pee led fruit

- cooked; fres h or N/ S; bake d ; o r w heat flour

- cooked ; fre s h o r N/ S, bak ed) u s ing publicly availab le r ec ip e translation fi les develop e d jointly by USDA/A RS and E PA. For chronic exposure assessment, c o n sumption data are averaged fo r the e ntire U . S . population and within population s ubgroup s . However , for acute expos ure assess ment , consumption data are retained as indi v idu a l consumption events. Based o n analysis of th e 2 00 3-20 08 WWEIA co nsumpti o n data , which took into account dietary pattern s and survey re s pond e nts , HED co ncluded th at it is mo s t appropriate to re port risk fo r th e fo ll ow ing population s ub gro up s: the ge neral U.S. population , all infants (< I ye ar old), ch ildre n 1- 2, children 3-5, children 6-12 , youth 13-1 9, adults 20 -49 , fe m a les 1 3-49, a nd adults 50 -99 years old. For a chronic dietary exposure assess me nt , an es timate of th e residue leve l in eac h food or food

form (e. g., orange o r orange juice) on the food commodity residu e li st is multipli ed by the 

### Page 4o f1 0Penoxsulam ( 11903 I) Dietary Exposure and Risk Assessment DP Numb er: 429010 

### average daily consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for eac h food/ food form is s ummed w ith the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated expos ure. Exposure i s expressed in mg/kg bod y weight / day and as a percent of the cPAD. This procedure is performed for eac h population subgroup. 

### V . Toxico lo g ica l Informati on The doses and endpoints for dietary exposure and risk assessment are summarized in Table 3 , below.

Table 3. S umma ry of Toxicologica l Do ses a nd Endp o int s for Penoxsu lam for Use in Di etary Exposure As sess me nt Exposure Point of Departure, FQPA SF and Level of Study and Toxicological Effect s Scenario UF Concern for Risk Assessment Acute Dietary None NIA No toxicological endpoint attributable (a ll populations) UF = N /A to a single exposure was identified in the available toxicology studies on penoxsulam. Chronic Dietary NOAEL= 14.7 FQPASF = lx I-Year Chronic Feeding Study in (all populations) mg/kg/day cPAD = Dogs. LOA EL = 46.2 mg/ k

g/day ba sed UF = 100 Ch roni c POD on multi-focal hyperpla sia of the pelvic FQPA SF epithelium of the kidne y . Chro ni c POD = 0.147 mg/kg/day = 0.147 mg/ k

g/day Cancer (oral, Suggestive Ev iden ce of Carcinogenicity , but Not Sufficient to Assess Hum an dennal. inhalation) Carcinogenic Potential Pomt of Departure (POD) == A data point or an estimated point that 1 s derived from observe d dose-respon se data and used to mark the beginning of extrapolation to determine risk associated with lower environmentall y relevant human exposures. NOA EL = no obse rv ed adverse effect level. LOAEL = low es t observed adverse effect level. UF == uncertainty factor. FQPA SF = FQPA Safety Factor. PAD == population adju sted dose (a = acute, c = chronic). N /A = not applicable. 

### VI. R esu lts / Discussion As stated above, HED is concerned whe n dietary risk exceeds 100% of the PAD. The DEEMFCIOTM analyses es timate the dietary exposure of the U.S. population and various population subgroups. The results , reported in Table 4, are for the ge n era l U.S. Population , all infants (< I 

### year o ld). children 1-2 , children 3 -5 , ch ildren 6 -12 , youth 1 3-19 , females 13

- 49 , adults 20 -4 9 , and adults 50 + years. Results of Chronic Dietary Expos ure Analvsis: P e nox sulam chronic dietary (food + drinking water) exposure estimates are below HED 's level of concern for the U.S. population and each of the population subgroups. Estimated chronic dietary exposure is 2% of the cPAD for the U . S. population. The chronic di etary expos ure estimate for the hi g he st reported exposed population subgroup , all infants ( < I year old), i s 6% of the cPAD. The re sults of the chronic dietary (food + drinking water) exposure analysis are rep o r1ed in Table 

### 4. Page 5of10Penoxsulam ( 119031) Dietary Exposure and Ri sk Assessment DP Number: 4290 I0

T a bl e 4. S ummary of Dieta ry (Food+ Orin kin2 Wate r) Exposu r e a nd Ri s k fo r Penox s ul am. Acute Dietary Chronic Dietary Cancer Dietary Dietary Dietary Exposure Exposure Exposure Population S ubgro up (mg/kg/day) o/oaPAD (mg/kg/day) o/oc PAD (mg/kg/day) Ri s k General U.S. Population 0.003173 2 All In fa nts(< I yea r o ld) 0.008222 6 Children 1-2 years old 0.004725 3 Chi ldren 3-5 years old 0.003929 3 Children 6-12 years old 

### N I A N I A 0.002798 2 

### N I A N I A Youth 1 3- 19 years old 0.002308 2 Adults 20-49 years old 0.003153 2 Adults 50 + year s o ld 0.003117 2 Females 1 3-49 years old 0.003140 2 The population subgroup with the highest exposure/risk estimate is bo ldcd . 

### VII . C h aracter iza ti o n of Inpu ts /O u tpu ts Thi s analysis is a conservative, unrefined dietary exposure assessment. Further refineme nt to the analysis could be made through the u se of anti c ipated r es idu es, incorporation of p e rcent crop treated information , and/ or monitorin g data that better reflect residues at the time of consumpt ion. Since risk estimates are below H E D 's level of co ncern, a more highly refi ned analysis is not needed at this time. The reported risk estimates are likely to be considerab ly hi g her than actual exposure to penoxsulam as a result of registered and proposed uses. Jn order to provide a comparison for ref e renc e, the dietary results for the analysis of food ex posures (only) are presented in attachment 3. 

### VIII. Conc lu s io n s Based on the conse r vative assumptions noted above, c hroni c dietar y risk est im ates for penoxsulam do not exceed H ED's level of concern for the general U.S. population , or any of the populati o n subgroups, includin g tho se compr ised of in fa nt s a nd ch ildre n. H E D is co nfid e nt th at the assessment does not underestimate ri sk to the general U.S. population or any population subgroup. 

### IX. Lis t of Attac hm en ts Attachment I: Chron ic Food plus Water Residue Input Fil e Attachment 

### 2: Chronic Food plus Water Result s File Attachment 3: Chronic Food Only Res ult s File

Page 6of10Penoxsu lam ( I 190 31) Dietary Exposure and Ri sk Asse ss ment DP Numb e r : 4290 I 0



### A ttachment 1. C hronic Food plus Wate r Res idue Input File Filename: F:\penoxsulam\Dietary\ll9031C

_ 090815 . R08 Chemical : Penoxsulam RfD{Chronic): .147 mg/kg bw/day NOEL(Chronic) : O mg/kg bw/day RfD (Acute) : O mg/kg bw/day NOEL( A cute) : 0 mg/kg bw/day Date created/last m o d ifie d: 09-10-2015/11 : 30:55 Program ver. 3.16, 03-08-d



### ----- - -------------------------- --- ---- - ---------- ----------- -- ---- - ----- -- ----- - -- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (pp m ) Ill 112



### ----- - ---- -- - -------------------- -- ------ 

### ---------- 

## ------- 1100007000 11 Apple, fruit with peel 0.010000 1.000 1.000 1100008000 11 Apple, pee l ed fruit 0 . 010000 1 . 000 1.000 1100008001 11 Apple, peeled fru i t-baby f ood 0 . 010000 1.000 1 . 000 1100009000 11 App l e, dried 0.010000 8.000 1.000 1100009001 11 Apple, dried-babyfood 0 . 010000 8.000 1 . 000 1100010000 11 App l e , juice 0 . 010000 1. 300 l. 000 1100010001 11 Apple, jui c e-babyfood 0.010000 1.300 1.000 1100011000 11 Apple, sauce 0 . 010000 1.000 1.000 1100011001 11 App l e, sauce-babyfood 0 . 010000 1.000 1.000 1100129000 11 Crabapple 0.010000 1 . 000 1.000 1100173500 11 Goji berry 0 . 010000 1.000 1.000 1100210000 11 Loquat 0.010000 1.000 1.000 1100266000 11 Pear 0 . 010000 1 . 000 1.000 1100266001 11 Pear-baby f ood 0 . 010000 1.000 1.000 1100267000 11 Pear, dried 0.010000 6.250 1.000 1100268000 11 Pear, juice 0 . 010000 1.000 1. 000 1100268001 11 Pear, juice-babyfood 0 . 010000 1 . 000 1 . 000 1100310000 11 Quince 0.010000 l. 000 1 . 000 1201090000 12A Cherry 0 . 010000 1.000 1.000 1201090001 12A Cherry-babyfood 0.010000 1.000 1 . 000 1201091000 12A Cherry, JU I. Ce 0.010000 1. 500 1. 000 1201091001 12A Cherry, juice-babyfood 0.010000 1.500 1.000 1202012000 12B Apricot 0.010000 1.000 1.000 1202012001 12B Apricot-babyfood 0 . 010000 1.000 1 . 000 1202013000 126 Apri cot, dried 0 . 010000 6.000 1.000 1202014000 126 Apricot, juice 0.010000 1.000 1.000 1202014001 126 Apricot, juice-babyfood 0 . 010000 l. 000 1.000 1202230000 126 Nectarine 0.010000 1 . 000 1. 000 1202260000 128 Peach 0.010000 1.000 1.000 1202260001 128 Peach-babyfood 0.010000 1.000 1.000 1202261000 128 Peach , dried 0 . 010000 7.000 1.000 1202261001 128 Peac h, dried-babyfood 0 . 010000 7.000 1.000 1202262000 126 Peach, juice 0.010000 1.000 1.000 1202262001 126 Peach, juice-babyfood 0.010000 1.000 1. 000 1203285000 12C Plum 0 . 010000 1.000 1 . 000 1203285001 12C Pl u m-babyfood 0.010000 1.000 1. 000 1203286000 12C Plum, prune, fresh 0.010000 1.000 1.000 1203286001 12C Plum , prune, fresh-babyfood 0.010000 l. 000 1. 000 1203287000 12C Plum , prune , drie d 0.010000 5 . 000 1 . 000 1203287001 12C Plum, prune, drie d -babyfood 0.010000 5.000 1.000 1203288000 12C Plum, prune, juice 0.010000 1.400 1.000 1203288001 12C Plum , prune, juice-babyfood 0 . 0 1 0000 1.400 1. 000 13021 74 000 136 Gooseberry 0 . 010000 1. 000 1.000 1304175000 130 Grape 0 . 010000 1.000 1.000 1304176000 130 Grape, juice 0.010000 1.200 1.000 1304176001 130 Grape , juice-babyfood 0 . 010000 1.200 1 . 000 1304179000 130 Grape, wine and s h erry 0.010000 1.200 1.000 1400003000 14 Almond 0 . 010000 1.000 1.000 1400003001 14 Almond-babyfood 0 . 010000 1.000 1.000 1400004000 14 Almo n d , oil 0.0 1 0000 1. 000 1. 000 1400004001 14 Almond, oil-babyfood 0.010000 1.000 1.000 1400059000 14 Brazil nut 0.010000 1.000 1.000 1400068000 14 Butternut 0 . 0 1 0000 1 . 000 1.000 1400081000 14 Cas h ew 0 . 010000 1.000 1.000 Page 7 of 10P e noxs ul am ( 11903 I) Dietary Expo sure and Ri sk Assess ment DP Numb er: 4290 I0 1400092000 14 Che stnut 0 . 010000 1.000 1 . 000 1400155000 14 Hazelnut 0 . 010000 1.000 1 . 000 1400156000 14 Hazelnut, oil 0 . 010000 1.000 1.000 1400185000 14 Hickory nut 0 . 010000 1.000 1.000 1400213000 14 Macadamia nut 0 . 010000 1. 000 1.000 1400269000 14 Pec an 0 . 010000 1.000 1 . 000 1 40027800 0 14 Pine nut 0 . 010000 1. 000 1.0 00 1400282000 14 Pistachio 0 .0 10000 1.000 1.000 1400391000 14 Walnut 0 . 010000 1 . 000 1 . 000 1500 323 000 15 Ri ce, whir.e 0 . 020000 1.000 1.000 1500323001 15 Rice , white

- babyfood 0 . 020000 1.000 1.000 1500324000 1 5 Rice, brown 0 . 020000 1. 000 1. 000 1500324001 15 Rice , brown-babyfood 0 . 020000 1 . 000 1 . 000 1500325000 15 Rice , flour 0 .02 0000 1 . 000 1 . 000 1500325001 15 Rice, flour-babyfood 0.020000 1. 000 1. 000 1500326000 15 Ric e, bran 0 . 0 20 000 1. 000 1.000 1500326001 15 Rice , bra n-babyfood 0 . 020000 1.000 1 . 000 1500405000 15 Wild rice 0.020000 1.000 1 . 000 8000157000 80 Fish -fre shwater finf is h 0 . 014000 1.000 1. 000 8000158000 80 Fish-freshwater finf ish , farm ra 0 . 014000 1 . 000 1.000 8000161000 80 Fish-shellfish, crustacean 0 . 014000 1. 000 1.000 8 0001 62000 80 Fish -shell fish, mollusc 0 . 028000 1 . 00 0 1.000 8601000000 86A Water, direct, all sources 0.150000 1.000 1.000 8602000000 86B war.er, indir ect, all sources 0 .15 0000 1 . 000 1 . 000 9500177000 0 Grape, leaves 0.010000 1. 000 1 . 000 9500178000 0 Grape, raisin 0.010000 4.300 1 . 000 9500235000 0 Olive 0 .0 10000 1.000 1 . 000 9500236000 0 Oli ve, oil 0 . 010000 1 . 000 1 . 000 9500289000 0 Pomegranate 0 . 010000 1.000 1 . 000

Page 8 of10Penoxs ulam ( 11 903 1) Dietar y Exp os ure and Risk Ass ess ment DP N umb er: 4290 I0 

### Attachment 2: Chronic Food plu s Water Re s ults File

us EPA Ver. 3 . 16, 03-0B-d DEEM-FCID Chronic analysis for PENOXSULAM N HANES 2003-2008 2-day Resid u e file name : F : \penoxsulam\Dietary\ll903lC_090815.R08 Adjustment factor #2 NOT used. Analysis Date 09-10-2015/11 : 48:49 Residue file da t ed : 09-10-2015/11:30 : 55 Reference dose (RfD, Chronic) a .147 mg/kg bw/day**== ===============================** **== ===** **=== ==** **=~ ====** **== ===** **== ===** **==================**

Population

Subgroup Total us Population H

ispanic Non

- Hisp

- White Non

- Hisp -Bl ack Non-Hisp -O ther Nursing Infants Non -Nursing Infants Female 13+ PREG Children 1-6 Children 7-12 Male 13-19 Female 13-19/NP Male 20+ Female 20+/NP Seniors SS+ All Infants Female 13

- so Children 1-2 Ch ildr en 3-S Children 6-12 Youth 13 -19 Adults 20

- 49 Adults S0-99 Female 13-49 Total exposure by p opulation subgro up Total Ex posure mg/kg body wt/day 0 . 003173 0.003039 0.003259 0.00262S 0.003669 0. 002916 0 . 010S91 0.002981 0.004lS8 0.002658 0.002l7S 0. 002438 0 . 002946 0.003317 0 . 0030S6 0.008222 0 . 003144 0.004725 0 . 003929 0.002798 0 . 002308 0. 0031S3 0. 003117 0 . 003140



### Page 9 o f I0 Percent of Rfd 2 . 2% 2 . 1% 2 . 2% 1. 8% 2 . S% 2 . 0% 7 . 2% 2 . 0% 2 . 8 % 1. 8% 1. S% l . 7% 2 . 0% 2.3% 2 . 1% 5 . 6% 2 . 1% 3 . 2% 2 . 7% 1. 9% 1.6% 2 . 1% 2.1% 2 . 1%P enoxsu lam ( I 1903 I ) Dietary Exposure and Ri sk As sess ment D P umb er: 429010 

### Attachment 3 : Chronic Food Only Results File

us EPA Ver. 3 . 16 , 03 -08

- d DEEM-FCID Chronic analysis for PENOXSULAM NHANES 2003-2008 2-day Re sidue file name : F:\penoxsulam\D ietary\11 903 1C_090815_noDW.R08 Adjustment factor #2 NOT used . An alysis Date 09-10-2015/16 :2 3:21 Residue file dated: 09-10-2015/16 : 23 :05 Referenc e dose (RfD , Chronic) 

### = . 147 mg/kg bw/day

Population

Subgroup Total US Population Hispanic Non

- Hisp

- White Non-Hisp-Black N

on-H is p-Other Nu rsing Infants Non-Nursing Infants Female 13+ PREG Ch il dren 1-6 Children 7-12 Ma le 13-19 Fe male 13-19/NP Ma le 20+ Female 20+/NP Seniors 55+ All Infants Female 13-50 Children 1-2 Children 3

- 5 Chi ldren 6-12 Youth 13-19 Ad ults 20-49 Adults 50-99 Female 13-49 Total exposure by population subgroup Total Exposure mg/kg body wt /day 0.000032 0.000040 0.000029 0 . 000034 0 . 000048 0.000075 0 . 000145 0.000024 0. 000135 0.000039 0 . 000016 0.000019 0 . 000020 0 . 000018 0.000019 0.000123 0 . 000018 0.000194 0.000112 0.000045 0 . 000017 0 . 000019 0.000019 0.000018



### Page 10of10 Percent of Rfd 0.0% 0 . 0% 0 . 0% 0 . 0% 0 . 0% 0 . 1% 0 . 1% 0 . 0% 0 . 1% 0 . 0% 0 . 0% 0.0 % 0.0 % 0 . 0% 0 . 0% 0 . 1% 0 . 0% 0 . 1% 0 . 1 % 0 . 0% 0 . 0% 0 . 0% 0 . 0% 0 . 0%