Acetochlor (PC Code 12160 1) Dietary Exposure and Risk Assessment DP #: 408112 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

Office of Chemical Safety and Pollution Prevention 

MEMORANDUM 

January 16, 2013 

SUBJECT: Acetochlor- Revised Acute and Chronic Dietary and Drinking Water Exposure 

and Risk Assessments. 

PC Code: 121601 DP Barcode: 4081 12 

Decision No.: 461987 Registration No.: 524-591 

Petition No.: PP#2F7996 Regulatory Action: Section 3 

Risk Assessment Type: Dietary Case No.: 7230 

TXR No.: NA CAS No: 34256-82-1 

MRID No.: NA 40 CFR: 180.470 

7

L 

Reviewer: Thurston G. Morton, Chemist ~ ~ ~ 

Through: 

TO: 

Risk Assessment Branch IV/Healtli Effects Division (RABIV/HED; 7509P) 

And 

Susan V. Hummel, Senior Chemist 

RABIV/HED (7509P) 

Hope Johnson 

Herbicide Branch/RD (7505P) 

This document provides an acute and chronic dietary and drinking water risk analyses of 

exposures resulting from use of acetochlor on food crops for weed control. This assessment 

supports a Section 3 request to remove the exception for rice as a rotational crop from the cereal 

grain inadvertent tolerances. No updated cumulative assessment is needed. 

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Acetochlor (PC Code 12160 1) Dietary Exposure and Risk Assessment DP #: 408112 

Executive Summary 

Unrefined acute and partially refined chronic dietary risk assessments were conducted for 

acetochlor. The analyses were performed to support Section 3 amendment and associated 

petition to remove the exception for rice as a rotational crop from the cereal grain inadvertent 

tolerances. 

Acute Dietary Exposure Analysis Results and Characterization 

A screening level acute dietary exposure analysis was performed for the general population and 

all population subgroups. The acute dietary analysis assumed tolerance level residues and 100% 

crop treated for all commodities. Experimentally derived processing factors were used for cereal 

grain commodities. Default processing factors were used for all other commodities. The acute 

analysis incorporated the 1 in 1 0 year peak surface drinking water estimate from application of 

acetochlor to sorghum. The resulting 95th percentile acute exposure estimate for infants < 1 year 

old (the most highly exposed subgroup) is not of concern to HED (<1% acute population 

adjusted dose (aPAD)). The exposure estimate for the U.S. population was< 1% ofthe aPAD. 

Chronic Dietary Exposure Analysis Results and Characterization 

A partially refined chronic dietary exposure analysis was performed for the general U.S. 

population and various population subgroups. Anticipated residues from field trial data and 100% 

crop treated assumptions were made for all commodities. Experimentally derived processing 

factors were used for cereal grain commodities. Default processing factors were used for all 

other commodities. The chronic analysis incorporated the 1 in 10 year average surface drinking 

water estimate from application of acetochlor to sorghum. Chronic dietary risk estimates are not 

of concern for general population or other population subgroups. The subgroup with the highest 

risk estimate was infants< 1 year old with an exposure estimate of6.2% of the cPAD. The 

general U.S. population estimated exposure was 2.1% of the cP AD. 

Cancer Dietary Exposure Analysis Results and Characterization 

HED has determined that linear quantification of carcinogenic potential is not required for the 

mouse tumors. There are acceptable mode of action data for the rat tumors (nasal olfactory 

epithelial tumors and thyroid follicular cell tumors) which are adequate to support a non-linear 

MOE approach for assessment of cancer risk. The rat nasal tumors, with a POD of 10 mg!kg/day 

are the most sensitive effect for cancer risk. Quantification of cancer risk is not required since 

the chronic RID of 0.02 mg!kg/day will be protective of both non-cancer and cancer effects, 

including rat nasal tumors, thyroid tumors, and mouse tumors. As noted above, chronic dietary 

risks do not exceed HED's level of concern. 

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Acetochlor (PC Code 121601) Dietary Exposure and Risk Assessment DP #: 408112

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Cumulative Dietary Exposure

Acetochlor is included in a Cumulative Assessment Group (CAG) of Chloroacetanilide 

pesticides. For purposes of a cumulative risk assessment, it was determined that the common 

mechanism of toxicity group consists of alachlor, acetochlor and butachlor. Based on the most 

recent chloroacetanilide CAG cumulative risk assessment, cumulative risk is not of concern. A 

revised quantitative cumulative assessment was not conducted because the proposed amended 

use would not affect the cumulative risk results. Not only is acetochlor is a very minor 

contributor to chloroacetanilide cumulative risk when compared to alachlor but removing the 

exception for rotation to rice will only have a minor impact on acetochlor exposure.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to point 

of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk exceeds one 

in one million. References which discuss the acute and chronic risk assessments in more detail 

are available on the EPA/pesticides web site: “Available Information on Assessing Exposure 

from Pesticides, A User’s Guide,” 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/EPAPEST/2000/July/Day-12/6061.pdf ; or see SOP 99.6 (20-AUG-1999).

Acetachlor had a previous dietary risk assessment conducted (B. Daiss, D360868, 7/1/09).

II. Residue Information

Residues of Concern 

The residues of concern in plants includes parent and any metabolites containing the ethyl methyl 

aniline (EMA) or hydroxyethyl methyl aniline (HEMA) moiety, expressed in acetochlor 

equivalents. The residues of concern in rotational crops are acetochlor, its EMA and HEMA type 

metabolites as well as its hydroxymethyl ethyl aniline (HMEA) type metabolites. HED has

concluded that the tolerance expression for rotational crops should include only acetochlor and 

its EMA and HEMA type metabolites; however the acetochlor HMEA type metabolites should 

be included in the risk assessment (M. Flood, MARC Memorandum, 9/30/93). Table 1 provides 

a summary of the MARC decisions regarding residues of concern for acetochlor. 
Acetochlor (PC Code 121601) Dietary Exposure and Risk Assessment DP #: 408112

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Table 1: Summary of MARC Decisions for Acetochlor

Matrix Residues of Concern 

For Risk Assessment For Tolerance Expression

Plants Parent and metabolites containing the EMA

or HEMA or HMEA moiety

Parent and metabolites containing the 

EMA or HEMA moiety

Rotational Crops Parent and metabolites containing the EMA

or HEMA or HMEA moiety

Parent and metabolites containing the 

EMA or HEMA moiety

Drinking Water Parent Only NA

Established/Recommended Tolerances

Tolerances for acetochlor are currently established under 40 CFR §180.470(a) and (d) 

Tolerances for acetochlor are expressed in terms of acetochlor and its metabolites containing the 

EMA (2-ethyl-6-methylaniline) and HEMA (2-(1-hydroxyethyl)-6-methylaniline) moieties. 

Tolerances for field corn, pop corn, sweet corn, and sorghum commodities range from 0.05 ppm 

to 3.0 ppm. Tolerances for rotational crops, nongrass animal feeds, sugar beet root and tops, 

cereal grain commodities, peas and beans, potato, soybean commodities, sunflower seed, and 

wheat commodities range from 0.1 ppm to 1.0 ppm. No tolerances have been established for 

livestock commodities. Recommended tolerances for the proposed new use are as follows (by 

removal of rice as an exception from the cereal grain tolerance). 

Rice, grain ............................................................................0.05 ppm

The submitted field trial data for all rotational commodities did not sample for the HMEA 

metabolite. However, no quantifiable residues of acetochlor or HEMA were found in any of the 

cereal grain, sugar beet, or potato commodities. Based on the available rotational crop 

metabolism studies conducted on lettuce, radish, and wheat, the EMA producing metabolites 

were present at the highest concentrations, followed by the HEMA- and HMEA-type metabolites. 

Therefore, if acetochlor or HEMA were non-quantifiable in any samples, it is reasonable to 

assume that HMEA would be less than LOQ and use of established tolerances for rotational 

crops is appropriate. 

Residues Used in the Acute Analysis

For the acute dietary analysis, tolerance level residues were used for all crops. 100% crop treated 

was assumed for all commodities in the assessment. Experimentally derived processing factors 

were applied to processed cereal grain commodities. DEEM Default processing factors were 

used for all other commodities.
Acetochlor (PC Code 121601) Dietary Exposure and Risk Assessment DP #: 408112

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Residues Used in the Chronic Analysis

For the chronic dietary analysis, tolerance level residues were used for rice, soybean and cotton 

commodities. Average field trial residue values were used for all other crops. 100% crop treated 

was assumed for all commodities in the assessment. Experimentally derived processing factors 

were applied to processed cereal grain commodities. DEEM Default processing factors were 

used for all other commodities.

Residues used in the acute and chronic dietary analyses are provided in Table 2.

Table 2. Data and Residue Estimates Used in Acetochlor Dietary and Drinking Water Analyses

RAC

Blending 

Status1

Data

Source LOD %CT PF

Residues (ppm)

Acute (Tol) Chronic (AR)

Beet, Sugar B

Tolerance & 

Field Trial Data 

45322103

24 samples

0.04 100 None 0.05 0.02

Cereal grain, except 

corn, sorghum and rice,

group 15 (barley, 

buckwheat, millet, oat, 

rye, triticale, wheat)

B

Tolerance & 

Field Trial Data 

45322108

17 samples

0.035 100 Flour 0.5X 

Groats 0.4X 0.05 0.02

Corn, field and pop, 

grain B

Tolerance & 

Field Trial Data 

41592014 

42713114; 15

40365601

2 samples

0.03 100

Flour, meal, 

starch and 

oil 0.6X

0.05 0.02

Corn, sweet, K-CWHR NB/PB

Tolerance & 

Field Trial Data 

44107105

32 samples

0.04 100 None 0.05 0.02

Pea and bean, dried 

shelled, except 

soybean, subgroup 6C

B

Tolerance & 

Field Trial Data 

45322104 

45322105

28 samples

0.04 100 None 0.05 0.02

Potato NB/PB/

B

Tolerance & 

Field Trial Data 

45322107

10 samples

0.04 100 Dried 6.5X 0.05 0.02

Soybean, seed B Tolerance N/A 100 Flour 0.75X 

Oil 0.2X 1.0 Tol 1.0

Sorghum B Tolerance N/A 100 None 0.05 Tol 0.05

Sunflower seed PB/B

Tolerance & 

Field Trial Data 

45322106

16 samples

0.04 100 None 0.05 0.02

Rice B Tolerance 0.05 100 0.05 0.05

Water N/A Modeling Data N/A N/A N/A 0.0749 0.00484

1

Classification of blended (B), partially blended (PB), not blended (NB).
Acetochlor (PC Code 121601) Dietary Exposure and Risk Assessment DP #: 408112

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III. Water Data

A new drinking water assessment did not need to be conducted for this amendment since no new 

primary crops were added, so the previous assessment was used. Drinking water residues were 

incorporated directly into the acute and chronic dietary analyses (“water, direct, all sources” and 

“water, indirect, all sources”) and were provided by the Environmental Fate and Effects Division 

(EFED) (D359995, M. Barrett, 6/24/2009). Acetochlor parent residue exposure is generally 

higher and more widespread through surface water sources than ground water, therefore, EFED 

generated the surface water concentrations using the PRZM (Pesticide Root Zone Model; version 

3.12 Beta compiled May 24, 2001) and EXAMS (Exposure Analysis Modeling System; version 

2.98.04, compiled November 12, 2002). The drinking water assessment provides modelingbased Tier 2 drinking water exposure estimates for the proposed uses of acetochlor on soybeans 

and cotton along with the existing uses on corn (including sweet corn, popcorn, field corn, and 

corn for silage) and sorghum. Estimates for the use of acetochlor on sorghum were used in the 

screening level dietary assessment because this use produces the EDWCs of the registered uses. 

Surface water EDWCs for acetochlor are provided in Table 3. Using Tier 2 estimation methods, 

parent acetochlor concentrations in drinking water are estimated to be up to 74.9 ug/L (ppb) for 

instantaneous exposure and 4.84 ppb for annual exposure.

Table 3. Modeled EDWCs for Use of Acetochlor on Sorghum (ug/L) Underlined values Recommended by 

EFED for Dietary Exposure Assessment.

Exposure Scenario Peak Day 365 Day Avg Lifetime (30 yr Avg)

KS Sorghum (2.5 lb ai/ A) 49.9 to 74.9 4.14 to 4.84 0.29 to 1.12

Corn – scenarios from IL, MS, 

NC, OH, and PA (3 lb ai/A rate)

14.3 to 44.5 2.08 to 6.56 0.72 to 2.96

Cotton – scenarios from CA, MS, 

and NC

3.56 to 20.0 0.55 to 2.16 0.29 to 1.12

MS Soybean 28.0 4.68 2.18

IV. DEEM-FCIDTM Program and Consumption Information

Acetochlor acute and chronic dietary exposure assessments were conducted using the Dietary 

Exposure Evaluation Model software with the Food Commodity Intake Database DEEMFCIDTM, Version 3.16, which incorporates consumption data from USDA’s National Health and 

Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA). This dietary 

survey was conducted from 2003 to 2008. The data are based on the reported consumption of 

more than 20,000 individuals over two non-consecutive survey days. Foods “as consumed” (e.g., 

apple pie) are linked to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh 

or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe 

translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, 

consumption data are averaged for the entire U.S. population and within population subgroups, 
Acetochlor (PC Code 121601) Dietary Exposure and Risk Assessment DP #: 408112

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but for acute exposure assessment are retained as individual consumption events. Based on 

analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns 

and survey respondents, HED concluded that it is most appropriate to report risk for the 

following population subgroups: the general U.S. population, all infants (<1 year old), children 1-

2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 years 

old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total average 

estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the 

cPAD. This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating 

relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for all tiers of analysis. However, for tiers 1 and 2, any significant 

differences in user vs. per capita exposure and risk are specifically identified and noted in the risk 

assessment.

V. Toxicological Information

HED evaluated the toxicology data base for acetochlor and selected the following doses and 

endpoints for acute and chronic dietary and drinking water risk assessments. 
Acetochlor (PC Code 121601) Dietary Exposure and Risk Assessment DP #: 408112

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Table 4. Summary of Toxicological Doses and Endpoints for Acetochlor for Use in Dietary and Non-Occupational Human 

Health Risk Assessments

Exposure/Scenario Point of 

Departure

Uncertainty/FQPA 

Safety Factors

RfD, PAD, LOC 

for Risk 

Assessment

Study and Toxicological Effects

Acute Dietary

(All populations)

NOAEL = 

150 

mg/kg/day

UFA= 10x

UFH=10x

FQPA SF= 1x

Acute RfD = 1.5

mg/kg/day

aPAD = 1.5

mg/kg/day

Acute oral neurotoxicity screening in rats

LOAEL = 500mg/kg/day based on decreased 

motor activity in females.

Chronic Dietary 

(All Populations)

NOAEL = 2.0 

mg/kg/day

UFA= 10x

UFH=10x

FQPA SF= 1x

Chronic RfD = 

0.02

mg/kg/day

cPAD = 0.02

mg/kg/day

Chronic oral toxicity in beagle dogs

LOAEL = 10 mg/kg/day based on increased 

salivation and histopathology in the testes, 

kidney and liver.

Cancer (all routes)

Classification: “Suggestive Evidence of Carcinogenic Potential". Quantification of cancer risk is not 

required since the cRfD of 0.02 mg/kg/day will be protective of both non-cancer and cancer effects

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and used to mark the beginning of 

extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. 

NOAEL = no observed adverse effect level. 

LOAEL = lowest observed adverse effect level. 

UF = uncertainty factor. 

UFA = extrapolation from animal to human (interspecies). 

UFH = potential variation in sensitivity among members of the human population (intraspecies). 

FQPA SF = FQPA Safety Factor. 

PAD = population adjusted dose (a = acute, c = chronic). 

RfD = reference dose. 

VI. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the U.S. 

population and various population subgroups. The results reported in Tables 5 and 6 are for the 

general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 

13-19, females 13-49, adults 20-49, and adults 50-99 years.

Results of Acute Dietary Exposure Analysis

The results of the acute dietary exposure analysis at the 95th percentile of exposure are reported in 

Table 5.
Acetochlor (PC Code 121601) Dietary Exposure and Risk Assessment DP #: 408112

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Table 5: Summary of Acute Dietary Exposure and Risk for Acetochlor

Population Subgroup aPAD (mg/kg/day) Acute (95th Percentile)

Exposure (mg/kg/day) % aPAD

General U.S. Population

0.15

0.004913 <1

All Infants (< 1 year old) 0.014093 <1

Children 1-2 years old 0.008084 <1

Children 3-5 years old 0.006749 <1

Children 6-12 years old 0.004796 <1

Youth 13-19 years old 0.003943 <1

Adults 20-49 years old 0.004696 <1

Adults 50-99 years old 0.004138 <1

Females 13-49 years old 0.004739 <1

Results of Chronic Dietary Exposure Analysis

The results of the chronic dietary exposure analysis are reported in Table 6. 

Table 6: Summary of Chronic Dietary Exposure and Risk for Acetochlor

Population Subgroup cPAD (mg/kg/day) Chronic

Exposure (mg/kg/day) % cPAD

General U.S. Population

0.002

0.000419 2.1

All Infants (< 1 year old) 0.000912 4.6

Children 1-2 years old 0.001244 6.2

Children 3-5 years old 0.000915 4.6

Children 6-12 years old 0.000537 2.7

Youth 13-19 years old 0.000315 1.6

Adults 20-49 years old 0.000359 1.8

Adults 50-99 years old 0.000331 1.7

Females 13-49 years old 0.000342 1.7

VI. Characterization of Inputs/Outputs

The acute dietary analysis is an unrefined screening level analysis. In addition, the 100% crop 

treated estimate used for all crops in the assessment will considerably overestimate the actual 

percent crop treated. 

The chronic dietary analysis is somewhat refined. Average field trial residues used in the 

analysis are expected to exceed the residues actually consumed. In addition, the 100% crop 

treated estimate used for all crops in the assessment will considerably overestimate the actual 

percent crop treated. 

VII. Conclusions

Acute and chronic dietary exposure analyses were performed for the general U.S. population and 

various population subgroups. The risk estimates for the general U.S. population and all 

population subgroups are below HED’s level of concern. HED is confident that acute and 

chronic dietary exposures to acetochlor are not underestimated.
Acetochlor (PC Code 121601) Dietary Exposure and Risk Assessment DP #: 408112

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VIII. Cumulative Risk

As part of the provisions of the Food Quality Protection Act (FQPA, 1996), EPA must 

consider the cumulative effects on human health that may result from exposure to different 

chemicals that cause toxic effects by the same mode of action. The chloroacetanilides have been 

evaluated by the Agency and the FIFRA Scientific Advisory Panel (SAP) as a related group of 

chemicals for this purpose. Acetochlor is included in a Cumulative Assessment Group (CAG) of 

Chloroacetanilide pesticides. Structurally related chloroacetanilides include acetochlor, alachlor, 

butachlor, propachlor and metolachlor. For purposes of a cumulative risk assessment, it was 

determined that the common mechanism of toxicity group consists of alachlor, acetochlor and 

butachlor. Butachlor is excluded from the group for risk assessment purposes at present there are 

no registered uses or tolerances for this chemical in the US. The group was selected based on 

common endpoints of (1) nasal turbinate tumors in rats, and a known mechanism of toxicity for 

development of these tumors and (2) induction of hepatic UDP-Glucuronosyl Transferase 

(UDPGT), which results in increased incidence of thyroid follicular cell tumors secondary to 

disruption of pituitary-thyroid homeostasis. Thyroid effects were not included in the final 

cumulative assessment of the chloroacetanilide herbicides because they were determined to occur 

at excessively toxic dose levels, and therefore were not considered relevant to human risk 

assessment. Nasal tumors represent the most sensitive endpoint for both compounds.

An updated cumulative risk assessment of the Chloroacetanilide (CAG) pesticides 

acetochlor and alachlor conducted in April, 2007 provides an assessment of existing and new 

uses of those chemicals to date (Y. Donovan, D336214, 4/30/07). Based on the most recent 

chloroacetanilide CAG cumulative risk assessment, cumulative risk is not of concern. A revised 

quantitative cumulative assessment was not conducted because the proposed amended use would 

not affect the cumulative risk results. Not only is acetochlor is a very minor contributor to 

chloroacetanilide cumulative risk when compared to alachlor but removing the exception for 

rotation to rice will only have a minor impact on acetochlor exposure.

 
Acetochlor (PC Code 121601) Dietary Exposure and Risk Assessment DP #: 408112

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VIII. List of Attachments

1. Acute DEEM-FCID Residue Input File.

2. Results of Acute DEEM-FCID Dietary Exposure Analysis.

3. Chronic DEEM-FCID Residue Input File.

4. Results of Chronic DEEM-FCID Dietary Exposure Analysis.
Acetochlor (PC Code 121601) Dietary Exposure and Risk Assessment DP #: 408112

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Attachment 1 Acute DEEM-FCID Residue Input File

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\121601 

Acetochlor\Acetochlor Adding Rice as a Rot Crop\121601 ACUTE.R08

Chemical: Acetochlor

RfD(Chronic): .02 mg/kg bw/day NOEL(Chronic): 2 mg/kg bw/day

RfD(Acute): 1.5 mg/kg bw/day NOEL(Acute): 150 mg/kg bw/day

Date created/last modified: 01-16-2013/12:06:04 Program ver. 3.16, 03-08-d

Comment: Run with new commodities at tolerance & 100% CT

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101052000 1A Beet, sugar 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0101052001 1A Beet, sugar-babyfood 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0101053000 1A Beet, sugar, molasses 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0103296000 1C Potato, chips 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0103297000 1C Potato, dry (granules/ flakes) 0.050000 6.500 1.000 new ro

 Full comment: new rot crop tol; 100% CT; PF used

0103297001 1C Potato, dry (granules/ flakes)-b 0.050000 6.500 1.000 new ro

 Full comment: new rot crop tol; 100% CT; PF used

0103298000 1C Potato, flour 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0103298001 1C Potato, flour-babyfood 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0103299000 1C Potato, tuber, w/peel 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0103299001 1C Potato, tuber, w/peel-babyfood 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0103300000 1C Potato, tuber, w/o peel 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0103300001 1C Potato, tuber, w/o peel-babyfood 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0600347000 6 Soybean, seed 1.000000 1.000 1.000 new to

 Full comment: new tolerance; 100% CT

0600349000 6 Soybean, soy milk 1.000000 1.000 1.000 new to

 Full comment: new tolerance; 100% CT

0600349001 6 Soybean, soy milk-babyfood or in 1.000000 1.000 1.000 new to

 Full comment: new tolerance; 100% CT

0600350000 6 Soybean, oil 1.000000 0.200 1.000 new to

 Full comment: new tolerance; 100% CT

0600350001 6 Soybean, oil-babyfood 1.000000 0.200 1.000 new to

 Full comment: new tolerance; 100% CT

0603030000 6C Bean, black, seed 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0603032000 6C Bean, broad, seed 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0603034000 6C Bean, cowpea, seed 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0603035000 6C Bean, great northern, seed 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0603036000 6C Bean, kidney, seed 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0603038000 6C Bean, lima, seed 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0603039000 6C Bean, mung, seed 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0603040000 6C Bean, navy, seed 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0603041000 6C Bean, pink, seed 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0603042000 6C Bean, pinto, seed 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0603098000 6C Chickpea, seed 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0603098001 6C Chickpea, seed-babyfood 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT
Acetochlor (PC Code 121601) Dietary Exposure and Risk Assessment DP #: 408112

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0603099000 6C Chickpea, flour 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0603182000 6C Guar, seed 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0603182001 6C Guar, seed-babyfood 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0603203000 6C Lentil, seed 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0603256000 6C Pea, dry 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0603256001 6C Pea, dry-babyfood 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0603258000 6C Pea, pigeon, seed 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

0603348000 6C Soybean, flour 1.000000 0.750 1.000 new to

 Full comment: new tolerance; 100% CT

0603348001 6C Soybean, flour-babyfood 1.000000 0.750 1.000 new to

 Full comment: new tolerance; 100% CT

1500025000 15 Barley, pearled barley 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100%CT

1500025001 15 Barley, pearled barley-babyfood 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100%CT

1500026000 15 Barley, flour 0.050000 0.500 1.000 new ro

 Full comment: new rot crop tol; 100% CT; PF used

1500026001 15 Barley, flour-babyfood 0.050000 0.500 1.000 new ro

 Full comment: new rot crop tol; 100% CT; PF used

1500027000 15 Barley, bran 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

1500065000 15 Buckwheat 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

1500066000 15 Buckwheat, flour 0.050000 0.500 1.000 new ro

 Full comment: new rot crop tol; 100% CT; PF used

1500120000 15 Corn, field, flour 0.050000 0.600 1.000 existi

 Full comment: existing use; 100% CT

1500120001 15 Corn, field, flour-babyfood 0.050000 0.600 1.000 existi

 Full comment: existing use; 100% CT

1500121000 15 Corn, field, meal 0.050000 0.600 1.000 existi

 Full comment: existing use; 100% CT

1500121001 15 Corn, field, meal-babyfood 0.050000 0.600 1.000 existi

 Full comment: existing use; 100% CT

1500122000 15 Corn, field, bran 0.050000 1.000 1.000 existi

 Full comment: existing use; 100% CT

1500123000 15 Corn, field, starch 0.050000 0.600 1.000 existi

 Full comment: existing use; 100% CT

1500123001 15 Corn, field, starch-babyfood 0.050000 0.600 1.000 existi

 Full comment: existing use; 100% CT

1500124000 15 Corn, field, syrup 0.050000 1.500 1.000 existi

 Full comment: existing use; 100% CT

1500124001 15 Corn, field, syrup-babyfood 0.050000 1.500 1.000 existi

 Full comment: existing use; 100% CT

1500125000 15 Corn, field, oil 0.050000 0.600 1.000 existi

 Full comment: existing use; 100% CT

1500125001 15 Corn, field, oil-babyfood 0.050000 0.600 1.000 existi

 Full comment: existing use; 100% CT

1500126000 15 Corn, pop 0.050000 1.000 1.000 new to

 Full comment: new tolerance; 100% CT

1500127000 15 Corn, sweet 0.050000 1.000 1.000 new to

 Full comment: new tolerance; 100% CT

1500127001 15 Corn, sweet-babyfood 0.050000 1.000 1.000 new to

 Full comment: new tolerance; 100% CT

1500226000 15 Millet, grain 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

1500231000 15 Oat, bran 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

1500232000 15 Oat, flour 0.050000 0.500 1.000 new ro

 Full comment: new rot crop tol; 100% CT; PF used

1500232001 15 Oat, flour-babyfood 0.050000 0.500 1.000 new ro

 Full comment: new rot crop tol; 100% CT; PF used

1500233000 15 Oat, groats/rolled oats 0.050000 0.400 1.000 new ro

 Full comment: new rot crop tol; 100% CT; PF used

1500233001 15 Oat, groats/rolled oats-babyfood 0.050000 0.400 1.000 new ro
Acetochlor (PC Code 121601) Dietary Exposure and Risk Assessment DP #: 408112

Page 14 of 19

 Full comment: new rot crop tol; 100% CT; PF used

1500323000 15 Rice, white 0.050000 1.000 1.000 

1500323001 15 Rice, white-babyfood 0.050000 1.000 1.000 

1500324000 15 Rice, brown 0.050000 1.000 1.000 

1500324001 15 Rice, brown-babyfood 0.050000 1.000 1.000 

1500325000 15 Rice, flour 0.050000 1.000 1.000 

1500325001 15 Rice, flour-babyfood 0.050000 1.000 1.000 

1500326000 15 Rice, bran 0.050000 1.000 1.000 

1500326001 15 Rice, bran-babyfood 0.050000 1.000 1.000 

1500328000 15 Rye, grain 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100% CT

1500329000 15 Rye, flour 0.050000 0.500 1.000 new ro

 Full comment: new rot crop tol; 100% CT; PF used

1500344000 15 Sorghum, grain 0.050000 1.000 1.000 new to

 Full comment: new tolerance; 100% CT

1500345000 15 Sorghum, syrup 0.050000 1.000 1.000 new to

 Full comment: new tolerance; 100% CT

1500381000 15 Triticale, flour 0.050000 0.500 1.000 new ro

 Full comment: new rot crop tol; 100%CT; PF Used

1500381001 15 Triticale, flour-babyfood 0.050000 0.500 1.000 new ro

 Full comment: new rot crop tol; 100%CT; PF Used

1500401000 15 Wheat, grain 0.050000 1.000 1.000 establ

 Full comment: established - rot crop; 100 % CT

1500401001 15 Wheat, grain-babyfood 0.050000 1.000 1.000 establ

 Full comment: established - rot crop; 100 % CT

1500402000 15 Wheat, flour 0.050000 0.500 1.000 establ

 Full comment: established - rot crop; 100 % CT; PF Used

1500402001 15 Wheat, flour-babyfood 0.050000 0.500 1.000 establ

 Full comment: established - rot crop; 100 % CT; PF Used

1500403000 15 Wheat, germ 0.050000 1.000 1.000 establ

 Full comment: established - rot crop; 100 % CT

1500404000 15 Wheat, bran 0.050000 1.000 1.000 establ

 Full comment: established - rot crop; 100 % CT

1500405000 15 Wild rice 0.050000 1.000 1.000 

2002364000 20B Sunflower, seed 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100%CT

2002365000 20B Sunflower, oil 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100%CT

2002365001 20B Sunflower, oil-babyfood 0.050000 1.000 1.000 new ro

 Full comment: new rot crop tol; 100%CT

2003128000 20C Cottonseed, oil 0.600000 1.000 1.000 new to

 Full comment: new tolerance; 100% CT

2003128001 20C Cottonseed, oil-babyfood 0.600000 1.000 1.000 new to

 Full comment: new tolerance; 100% CT

8601000000 86A Water, direct, all sources 0.074900 1.000 1.000 Based 

 Full comment: Based on corn monitoring data

8602000000 86B Water, indirect, all sources 0.074900 1.000 1.000 Based 

 Full comment: Based on corn monitoring data
Acetochlor (PC Code 121601) Dietary Exposure and Risk Assessment DP #: 408112

Page 15 of 19

Attachment 2 Results of Acute DEEM-FCID Dietary Exposure Analysis

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID ACUTE Analysis for ACETOCHLOR NHANES 2003-2008 2-Day

Residue file: 121601 ACUTE.R08 Adjustment factor #2 NOT used.

Analysis Date: 01-16-2013/12:13:13 Residue file dated: 01-16-2013/12:06:04

NOEL (Acute) = 150.000000 mg/kg body-wt/day

RAC/FF intake summed over 24 hours

Run Comment: "Run with new commodities at tolerance & 100% CT"

===============================================================================

Summary calculations--per capita:

--- 95th Percentile---- --- 99th Percentile---- ---99.9th Percentile----

Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

Total US Population:

 0.004913 0.33 30528 0.008861 0.59 16927 0.020271 1.35 7399 

All Infants:

 0.014093 0.94 10643 0.020274 1.35 7398 0.041625 2.78 3603 

Children 1-2:

 0.008084 0.54 18554 0.025015 1.67 5996 0.088443 5.90 1696 

Children 3-5:

 0.006749 0.45 22224 0.015355 1.02 9768 0.044854 2.99 3344 

Children 6-12:

 0.004796 0.32 31276 0.008888 0.59 16876 0.028437 1.90 5274 

Youth 13-19:

 0.003943 0.26 38041 0.006340 0.42 23659 0.012954 0.86 11579 

Adults 20-49:

 0.004696 0.31 31939 0.007393 0.49 20289 0.012381 0.83 12115 

Adults 50-99:

 0.004138 0.28 36250 0.006680 0.45 22455 0.014170 0.94 10585 

Female 13-49:

 0.004739 0.32 31653 0.007265 0.48 20645 0.012649 0.84 11858 
Acetochlor (PC Code 121601) Dietary Exposure and Risk Assessment DP #: 408112

Page 16 of 19

Attachment 3 Chronic DEEM-FCID Residue Input File.

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\121601 

Acetochlor\Acetochlor Adding Rice as a Rot Crop\121601 CHRONIC.R08

Chemical: Acetochlor

RfD(Chronic): .02 mg/kg bw/day NOEL(Chronic): 2 mg/kg bw/day

RfD(Acute): 1.5 mg/kg bw/day NOEL(Acute): 150 mg/kg bw/day

Date created/last modified: 01-16-2013/12:06:32 Program ver. 3.16, 03-08-d

Comment: Run with new commodities at tolerance & 100% CT

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101052000 1A Beet, sugar 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0101052001 1A Beet, sugar-babyfood 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0101053000 1A Beet, sugar, molasses 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0103296000 1C Potato, chips 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0103297000 1C Potato, dry (granules/ flakes) 0.020000 6.500 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT; PF used

0103297001 1C Potato, dry (granules/ flakes)-b 0.020000 6.500 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT; PF used

0103298000 1C Potato, flour 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0103298001 1C Potato, flour-babyfood 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0103299000 1C Potato, tuber, w/peel 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0103299001 1C Potato, tuber, w/peel-babyfood 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0103300000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0103300001 1C Potato, tuber, w/o peel-babyfood 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0600347000 6 Soybean, seed 1.000000 1.000 1.000 new to

 Full comment: new tol; tol; 100% CT

0600349000 6 Soybean, soy milk 1.000000 1.000 1.000 new to

 Full comment: new tol; tol; 100% CT

0600349001 6 Soybean, soy milk-babyfood or in 1.000000 1.000 1.000 new to

 Full comment: new tol; tol; 100% CT

0600350000 6 Soybean, oil 1.000000 0.200 1.000 new to

 Full comment: new tol; tol; 100% CT

0600350001 6 Soybean, oil-babyfood 1.000000 0.200 1.000 new to

 Full comment: new tol; tol; 100% CT

0603030000 6C Bean, black, seed 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0603032000 6C Bean, broad, seed 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0603034000 6C Bean, cowpea, seed 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0603035000 6C Bean, great northern, seed 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0603036000 6C Bean, kidney, seed 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0603038000 6C Bean, lima, seed 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0603039000 6C Bean, mung, seed 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0603040000 6C Bean, navy, seed 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0603041000 6C Bean, pink, seed 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0603042000 6C Bean, pinto, seed 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0603098000 6C Chickpea, seed 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0603098001 6C Chickpea, seed-babyfood 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT
Acetochlor (PC Code 121601) Dietary Exposure and Risk Assessment DP #: 408112

Page 17 of 19

0603099000 6C Chickpea, flour 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0603182000 6C Guar, seed 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0603182001 6C Guar, seed-babyfood 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0603203000 6C Lentil, seed 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0603256000 6C Pea, dry 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0603256001 6C Pea, dry-babyfood 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0603258000 6C Pea, pigeon, seed 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

0603348000 6C Soybean, flour 1.000000 0.750 1.000 new to

 Full comment: new tol; tol; 100% CT

0603348001 6C Soybean, flour-babyfood 1.000000 0.750 1.000 new to

 Full comment: new tol; tol; 100% CT

1500025000 15 Barley, pearled barley 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 L0Q; 100% CT

1500025001 15 Barley, pearled barley-babyfood 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 L0Q; 100% CT

1500026000 15 Barley, flour 0.020000 0.500 1.000 new ro

 Full comment: new rot crop use; 1/2 L0Q; 100% CT; PF used

1500026001 15 Barley, flour-babyfood 0.020000 0.500 1.000 new ro

 Full comment: new rot crop use; 1/2 L0Q; 100% CT; PF used

1500027000 15 Barley, bran 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 L0Q; 100% CT

1500065000 15 Buckwheat 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use: 1/2 LOQ; 100% CT

1500066000 15 Buckwheat, flour 0.020000 0.500 1.000 new ro

 Full comment: new rot crop use: 1/2 LOQ; 100% CT; PF used

1500120000 15 Corn, field, flour 0.020000 0.600 1.000 existi

 Full comment: existing use

1500120001 15 Corn, field, flour-babyfood 0.020000 0.600 1.000 existi

 Full comment: existing use

1500121000 15 Corn, field, meal 0.020000 0.600 1.000 existi

 Full comment: existing use

1500121001 15 Corn, field, meal-babyfood 0.020000 0.600 1.000 existi

 Full comment: existing use

1500122000 15 Corn, field, bran 0.020000 1.000 1.000 existi

 Full comment: existing use

1500123000 15 Corn, field, starch 0.020000 0.600 1.000 existi

 Full comment: existing use

1500123001 15 Corn, field, starch-babyfood 0.020000 0.600 1.000 existi

 Full comment: existing use

1500124000 15 Corn, field, syrup 0.020000 1.500 1.000 existi

 Full comment: existing use

1500124001 15 Corn, field, syrup-babyfood 0.020000 1.500 1.000 existi

 Full comment: existing use

1500125000 15 Corn, field, oil 0.020000 0.600 1.000 existi

 Full comment: existing use

1500125001 15 Corn, field, oil-babyfood 0.020000 0.600 1.000 existi

 Full comment: existing use

1500126000 15 Corn, pop 0.020000 1.000 1.000 new to

 Full comment: new tol; 1/2 LOQ; 100% CT

1500127000 15 Corn, sweet 0.020000 1.000 1.000 new to

 Full comment: new tol; 1/2 LOQ; 100% CT

1500127001 15 Corn, sweet-babyfood 0.020000 1.000 1.000 new to

 Full comment: new tol; 1/2 LOQ; 100% CT

1500226000 15 Millet, grain 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

1500231000 15 Oat, bran 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

1500232000 15 Oat, flour 0.020000 0.500 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT; PF used

1500232001 15 Oat, flour-babyfood 0.020000 0.500 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT; PF used

1500233000 15 Oat, groats/rolled oats 0.020000 0.400 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT; PF used

1500233001 15 Oat, groats/rolled oats-babyfood 0.020000 0.400 1.000 new ro
Acetochlor (PC Code 121601) Dietary Exposure and Risk Assessment DP #: 408112

Page 18 of 19

 Full comment: new rot crop use; 1/2 LOQ; 100% CT; PF used

1500323000 15 Rice, white 0.050000 1.000 1.000 

1500323001 15 Rice, white-babyfood 0.050000 1.000 1.000 

1500324000 15 Rice, brown 0.050000 1.000 1.000 

1500324001 15 Rice, brown-babyfood 0.050000 1.000 1.000 

1500325000 15 Rice, flour 0.050000 1.000 1.000 

1500325001 15 Rice, flour-babyfood 0.050000 1.000 1.000 

1500326000 15 Rice, bran 0.050000 1.000 1.000 

1500326001 15 Rice, bran-babyfood 0.050000 1.000 1.000 

1500328000 15 Rye, grain 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

1500329000 15 Rye, flour 0.020000 0.500 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

1500344000 15 Sorghum, grain 0.050000 1.000 1.000 new to

 Full comment: new tol; tol; 100% CT

1500345000 15 Sorghum, syrup 0.050000 1.000 1.000 new to

 Full comment: new tol; tol; 100% CT

1500381000 15 Triticale, flour 0.020000 0.500 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT; PF used

1500381001 15 Triticale, flour-babyfood 0.020000 0.500 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT; PF used

1500401000 15 Wheat, grain 0.020000 1.000 1.000 existi

 Full comment: existing rot crop use; 100% CT

1500401001 15 Wheat, grain-babyfood 0.020000 1.000 1.000 existi

 Full comment: existing rot crop use; 100% CT

1500402000 15 Wheat, flour 0.020000 0.500 1.000 existi

 Full comment: existing rot crop use; 100% CT; new PF used

1500402001 15 Wheat, flour-babyfood 0.020000 0.500 1.000 existi

 Full comment: existing rot crop use; 100% CT; new PF used

1500403000 15 Wheat, germ 0.020000 1.000 1.000 existi

 Full comment: existing rot crop use; 100% CT

1500404000 15 Wheat, bran 0.020000 1.000 1.000 existi

 Full comment: existing rot crop use; 100% CT

1500405000 15 Wild rice 0.050000 1.000 1.000 

2002364000 20B Sunflower, seed 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

2002365000 20B Sunflower, oil 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

2002365001 20B Sunflower, oil-babyfood 0.020000 1.000 1.000 new ro

 Full comment: new rot crop use; 1/2 LOQ; 100% CT

2003128000 20C Cottonseed, oil 0.600000 1.000 1.000 new to

 Full comment: new tol; tol; 100% CT

2003128001 20C Cottonseed, oil-babyfood 0.600000 1.000 1.000 new to

 Full comment: new tol; tol; 100% CT

8601000000 86A Water, direct, all sources 0.004840 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.004840 1.000 1.000 
Acetochlor (PC Code 121601) Dietary Exposure and Risk Assessment DP #: 408112

Page 19 of 19

Attachment 4 Results of Chronic DEEM-FCID Dietary Exposure Analysis.

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for ACETOCHLOR NHANES 2003-2008 2-day

Residue file name: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\121601 

Acetochlor\Acetochlor Adding Rice as a Rot Crop\121601 CHRONIC.R08

 Adjustment factor #2 used.

Analysis Date 01-16-2013/12:11:47 Residue file dated: 01-16-2013/12:06:32

Reference dose (RfD, Chronic) = .02 mg/kg bw/day

COMMENT 1: Run with new commodities at tolerance & 100% CT

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.000419 2.1%

Hispanic 0.000438 2.2%

Non-Hisp-White 0.000407 2.0%

Non-Hisp-Black 0.000371 1.9%

Non-Hisp-Other 0.000642 3.2%

Nursing Infants 0.000297 1.5%

Non-Nursing Infants 0.001186 5.9%

Female 13+ PREG 0.000392 2.0%

Children 1-6 0.001041 5.2%

Children 7-12 0.000461 2.3%

Male 13-19 0.000313 1.6%

Female 13-19/NP 0.000319 1.6%

Male 20+ 0.000337 1.7%

Female 20+/NP 0.000355 1.8%

Seniors 55+ 0.000324 1.6%

All Infants 0.000912 4.6%

Female 13-50 0.000340 1.7%

Children 1-2 0.001244 6.2%

Children 3-5 0.000915 4.6%

Children 6-12 0.000537 2.7%

Youth 13-19 0.000315 1.6%

Adults 20-49 0.000359 1.8%

Adults 50-99 0.000331 1.7%

Female 13-49 0.000342 1.7%

-------------------------------------------------------------------------------