Penoxsulam (I 19031) Dietary Exposure and Risk Assessment DP Number: 4290 I 0 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

MEMORANDUM 

Date: December 4, 2015 

OFFICE OF CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

SUBJECT: Penoxsulam. Chronic Aggregate Dietary (Food and Drinking Water) Exposure 

and Risk Assessment for the Section 3 Registration on Pome Fruit, Stone Fruit, 

Olive, Pomegranate, and Fruit, Small, Vine Climbing (Subgroup 13-07F, Except 

Fuzzy Kiwifruit); and Crop Group Conversion for Tree Nuts. 

PC Code: 11903 I DP Barcode: D4290 I 0 

Decision No.: 497353 Registration No.: 62719-499, 62719-611 

Petition No.: 4E8330 Regulatory Action: Section 3 Registration 

Risk Assessment Type: Single chemical, aggregate Case No.: NA 

TXR No.: NA CAS No.: 2 19714-96-2 

MRJD No.: None 40 CFR: 180.605 

FROM: Elizabeth Holman, Physical Scientist ~ )+.,~ 

Risk Assessment Branch II 

Health Effects Division (7509P) ~ 

THROUGH: 

Seyed 

Mohsen 

Tadayon

Sahafeyan, 

, Chemist 

Chemi

~~:;-_.. 

s;· '~~ \__ 47f% / ~/ ~ 

Dietary Exposure Science Advi;?r'Y Council (DES C) 

Health Effects Division (7509P) 

TO: Sidney Jackson/Barbara Madden 

Minor Use and Emergency Response Branch 

Registration Division (7505P) 

Executive Summary 

Chronic aggregate dietary [food and drinking water] exposure and risk assessments were 

conducted using the Dietary Exposw-e Evaluation Model software with the Food Commodity 

Intake Database (DEEM-FCID) Version 3. 16. This software uses 2003-2008 food consumption 

data from the U.S. Department of Agriculture's (USDA's) National Health and Nutrition 

Examination Survey, What We Eat in America, (NHANES/WWEIA). The analysis was 

conducted in support of a human-health risk assessment for the proposed Section 3 uses of 

penoxsulam on pome fruit, stone fruit, olive, pomegranate, and fruit. small, vine climbing 

Page I of I 0 
Penoxsulam (I 19031 ) Dietary Exposure and Risk Assessmen1 DP Number: 4290 I 0 

(Subgroup l 3-07F, except fuzzy kiwifruit), plus crop group conversion for tree nuts. 

Specifically, crop group conversions include the conversion of tree nut group 14 to tree nut 

group 14-12. In addition, the existing tolerance on grape is being converted to a crop group 

tolerance on fruit, small, vine climbing (Subgroup 13-07F, except fuzzy kiwifruit). This 

memorandum was reviewed by two peer reviewers of the DESAC, per DESAC SOP 2012.1. 

In calculating dietary risk estimates, HED has compared the chronic population adjusted dose 

(cPAD) to the respective estimated dietary exposures. Typically, HED has concerns regarding 

dietary risk when the estimates exceed 100% of the cPAD. With the conservative assumptions 

noted below, risk estimates associated with dietary exposure to penoxsulam are significantly 

below HED's level of concern. No single dose effects were noted in the toxicity studies for 

penoxsulam, so an acute dietary exposure and risk assessment was not required. 

Penoxsulam has been classified as having .. suggestive evidence of carcinogenicity, but not 

sufficient to assess human carcinogenic potential." As such, the chronic assessment is believed 

to be protective of potential carcinogenic effects; therefore, a separate cancer assessment was not 

required. 

An unrefined chronic dietary analysis for penoxsulam was conducted using tolerance level 

residues and 100% crop-treated (CT) for all existing and proposed uses. Default processing 

factors were used for all processed commodities. Drinking water was incorporated directly into 

the dietary assessment using the maximum estimated chronic concentration associated with the 

aquatic use of penoxsulam. The chronic risk estimates from dietary (food + drinking water) 

exposure to penoxsulam do not exceed HED's level of concern for the general U.S. population, 

or any of the population subgroups. The chronic dietary risk estimate for the highest exposed 

population subgroup, all infants (< I year old), is 6% of the cPAD. The general U.S. population 

utilizes 2% of the cPAD. 

I. Introduction 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the 

point of departure (POD, NOA EL, LOAEL, e.g.) divided by the required uncertainty or safety 

factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in 

more detail are available on the EPNpesticides web site: "Available Information on Assessing 

Exposure from Pesticides, A User's Guide,'· 21 -JUN-2000, web link: 

http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPP-2007-0780-0001; or see SOP 

99 .6 (20-A UG-1999). 

The most recent dietary risk assessment for penoxsulam was conducted by M. Doherty 

(03/24/2009, 0360419). 

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Penoxsulam ( 119031) Dietary Exposure and Risk Assessment DP Number: 429010 

II. Residue Informa tion 

Tolerances for residues of penoxsulam,per se, [40 CFR 180.605] have been established for fish 

(0.01 ppm), crustaceans (0.0 l ppm), mollusks (0.02 ppm), rice grain (0.02 ppm), and rice straw 

(0.50 ppm), as well as 0.01 ppm in grape and tree nut (including pistachio) commodities. There 

are no tolerances established for meat, milk, or poultry commodities. 

Recommended Tolerances: As part of the current petition (4E8330), under 40 CFR 180.605 

(Table 1), HED recommends (E. Holman. DP4250 I 3, 12/04/2015) for the tolerances of 

penoxsulam on pome fruit, stone fruit, olive, pomegranate, as well as crop group conversion for 

tree nuts and crop group expansion for fruit, small, vine climbing (Subgroup l 3-07F, except 

fuzzy kiwifruit). 

TABLE 1. Tolera nce Summary for Penoxsulam (40CFR §180.605). 

Proposed or Existing* Proposed or Existing* Recommended Correct Commodity Defi11ition; 

Commodity Tolerance (ppm) Tolerance loom) Comments 

40CFR §180.S44la llll 

Fruit, Pome, group 11-10 0.01 0.01 Fruit, pome, group I 1-10 

Fruit, Stone. group 12-12 0.01 0.01 Fruit, stone, group 12-12 

Fruit, small, vine 0.01 0.01 Based on available data on grape. 

climbing, subgroup 13-

07F, except fuzzy 

kiwifruit 

Nut, Tree group 14-12 0.01 0.01 N111, tree, group 1./-12; Conversion from 

tree nut group 14. 

Olive 0.01 0.01 Based on submitted stone fruit and 

Pomegranate 0.01 0.01 pome fruit field trial data. 

Nut, tree, group 14 0.01 • Remove Conversion to tree nut group 14-12. 

Grape 0.01• Remove Replace with tolerance on Fruit, small, 

vine climbing, subgroup 13-07F, except 

fuzzy kiwifruit. 

Pistachio 0.01 • Remove Replace with the tolerance on tree nut 

group 14-12. 

• A tolerance is currently established at the listed tolerance level in the corresponding commodity. 

Residue Data Used for Chronic Assessment: Tolerance-level residues were used for all entries in 

the assessment, except for fish, crustaceans, and mollusks, for which residue values include the 

5-hydroxy metabolite of penoxsulam; and it was assumed that all crops/foods with existing or 

proposed tolerances were treated (i. e., 100% CT). The fish and shell fish expression for risk 

assessment purposes is penoxsularn and its metabolite 5-0H penoxsulam. To account for the 

presence of the metabolite, the parent tolerance is multiplied by a factor of l .4X (PP#5F7012, 

DP Nurn: 326985, D. Soderberg, l/30/07). Therefore, the penoxsulam residue levels for fish and 

crustacean is 0.014 ppm (0.01 ppm tolerance x 1.4 = 0.014 ppm) and for mollusc is 0.028 ppm 

(0.02 ppm tolerance x 1.4 = 0.028 ppm). 

The available grape processing study showed no concentration of penoxsulam residues upon 

processing. However, as there were no quantifiable residues of penoxsulam in either the grape 

raw agricultural commodity or the grape processed commodities, no empirical processing factors 

Page 3of10 
Penoxsulam (I 1903 I) Dietary Exposure and Risk Assessment DP Number: 4290 I 0 

could be calculated. In addition, ChemSAC previously concluded that as long as the field trials 

showed no quantifiable residues, additional processing studies are not required to support 

penoxsulam tolerances on pome fruit and stone fruit (ChemSAC minutes, 09/01/20 l 0). The 

available field trial data showed no quantifiable residues above the limit of quantitation of 0.01 

ppm for these commodities (E. Holman, D42501 3, 12/04/2015). Therefore, default processing 

factors from DEEM 7.81 were used for all processed commodities of grape, pome fruit, and 

stone fruit. 

Ill. Drinking Water Data 

The Environmental Fate and Effects Division (EFED) has provided HED with Tier l modeled 

estimates of penoxsulam residues of concern in drinking water based on the proposed new uses, 

as well as the existing use pattern (J. Wolf, 28 Aug 2015, D42841 9). The proposed new uses 

result in lower drinking water estimates than those from the existing use pattern. Based on the 

existing turf grass use pattern (0.09 lb a.i./ A), residues of penoxsulam are not expected to be 

greater than 0.0463 ppm (Table 2). Penoxsulam is registered for control of aquatic weeds. For 

that use pattern, the maximum application rate is 150 ppb (0.15 ppm) in the water column. For 

this assessment, HED has used 0.15 ppm as a high-end estimate of penoxsulam residues in 

drinking water. The 0.15-ppm value is likely to be an overestimate of actual residues in drinking 

water. Residues were incorporated in the DEEM-FCID into the food categories "water, direct, 

all sources" and "water, indirect, all sources." 

Table 2. Summary of Resid ue Estimates for Penoxsulam in Drinking Water. 

Turf Use 

Duration Aquatic Use, ppm Surface Water, ppm Ground Water, ppm 

Acute 0. 15 0.00154 0.0463 

Chronic 0. 15 0.000 11 0.0313 

IV. DEEM-FCJDTM Program and Consumption Information 

The penoxsul am chronic dietary exposure assessment was conducted using the DEEM-FCID, 

Version 3.16, which incorporates 2003-2008 consumption data from USDA's 

NI IANES/WWEIA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods "as consumed" (e.g., apple pie) are 

linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation fi les 

developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups. However, for acute 

exposure assessment, consumption data are retained as individual consumption events. Based on 

analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns 

and survey respondents, HED concluded that it is most appropriate to report risk for the 

following population subgroups: the general U.S. population, all infants (< I year old), children 

1-2, children 3-5, children 6-12, youth 13-1 9, adults 20-49, females 13-49, and adults 50-99 

years old. 

For a chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

Page 4of1 0 
Penoxsulam ( 11903 I) Dietary Exposure and Risk Assessment DP Number: 429010 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup. 

V. Toxicological Information 

The doses and endpoints for dietary exposure and risk assessment are summarized in Table 3, 

below. 

Table 3. Summa ry of Toxicological Doses a nd Endpoints for Penoxsulam for Use in Dietary Exposure 

Assessment 

Exposure Point of Departure, FQPA SF and Level of Study and Toxicological Effects 

Scenario UF Concern for Risk 

Assessment 

Acute Dietary None NIA No toxicological endpoint attributable 

(all populations) UF = N/A to a single exposure was identified in 

the available toxicology studies on 

penoxsulam. 

Chronic Dietary NOAEL= 14.7 FQPASF = lx I-Year Chronic Feeding Study in 

(all populations) mg/kg/day cPAD = Dogs. LOA EL = 46.2 mg/kg/day based 

UF = 100 Chronic POD on multi-focal hyperplasia of the pelvic 

FQPA SF epithelium of the kidney. 

Chronic POD = 

0.147 mg/kg/day = 0.147 mg/kg/day 

Cancer (oral, Suggestive Evidence of Carcinogenicity, but Not Sufficient to Assess Human 

dennal. inhalation) Carcinogenic Potential 

Pomt of Departure (POD) == A data point or an estimated point that 1s derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOA EL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF == 

uncertainty factor. FQPA SF = FQPA Safety Factor. PAD == population adjusted dose (a = acute, c = chronic). N/A 

= not applicable. 

VI. Results/Discussion 

As stated above, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEMFCIOTM analyses estimate the dietary exposure of the U.S. population and various population 

subgroups. The results, reported in Table 4, are for the general U.S. Population, all infants (<I 

year old). children 1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, 

and adults 50+ years. 

Results of Chronic Dietary Exposure Analvsis: Penoxsulam chronic dietary (food + drinking 

water) exposure estimates are below HED's level of concern for the U.S. population and each of 

the population subgroups. Estimated chronic dietary exposure is 2% of the cPAD for the U.S. 

population. The chronic dietary exposure estimate for the highest reported exposed population 

subgroup, all infants (< I year old), is 6% of the cPAD. 

The results of the chronic dietary (food + drinking water) exposure analysis are repor1ed in Table 

4. 

Page 5of10 
Penoxsulam ( 119031) Dietary Exposure and Risk Assessment DP Number: 4290 I 0 

Table 4. Summary of Dietary (Food+ Orin kin2 Water) Exposure and Risk for Penoxsulam. 

Acute Dietary Chronic Dietary Cancer 

Dietary Dietary Dietary 

Exposure Exposure Exposure 

Population Subgroup (mg/kg/day) o/oaPAD (mg/kg/day) o/ocPAD (mg/kg/day) Risk 

General U.S. Population 0.003173 2 

All Infants(< I year old) 0.008222 6 

Children 1-2 years old 0.004725 3 

Children 3-5 years old 0.003929 3 

Children 6-12 years old NIA NIA 0.002798 2 NIA NIA 

Youth 13- 19 years old 0.002308 2 

Adults 20-49 years old 0.003153 2 

Adults 50+ years old 0.003117 2 

Females 13-49 years old 0.003140 2 

The population subgroup with the highest exposure/risk estimate is boldcd. 

VII. Characterization of Inputs/Outputs 

This analysis is a conservative, unrefined dietary exposure assessment. Further refinement to the 

analysis could be made through the use of anticipated residues, incorporation of percent crop 

treated information, and/or monitoring data that better reflect residues at the time of 

consumption. Since risk estimates are below HED's level of concern, a more highly refined 

analysis is not needed at this time. The reported risk estimates are likely to be considerably 

higher than actual exposure to penoxsulam as a result of registered and proposed uses. Jn order 

to provide a comparison for reference, the dietary results for the analysis of food exposures 

(only) are presented in attachment 3. 

VIII. Conclusions 

Based on the conservative assumptions noted above, chroni c dietary risk estimates for 

penoxsulam do not exceed HED's level of concern for the general U.S. population, or any of the 

population subgroups, including those comprised of infants and children. HED is confident that 

the assessment does not underestimate risk to the general U.S. population or any population 

subgroup. 

IX. List of Attachments 

Attachment I: Chronic Food plus Water Residue Input File 

Attachment 2: Chronic Food plus Water Results File 

Attachment 3: Chronic Food Only Results File 

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Penoxsu lam ( I 19031) Dietary Exposure and Risk Assessment DP Number: 4290 I 0 

Attachment 1. Chronic Food plus Water Residue Input File 

Filename: F:\penoxsulam\Dietary\ll9031C_ 090815 . R08 Chemical : Penoxsulam 

RfD{Chronic): .147 mg/kg bw/day NOEL(Chronic) : O mg/kg bw/day 

RfD (Acute) : O mg/kg bw/day NOEL(Acute) : 0 mg/kg bw/day 

Date created/last mod ified: 09-10-2015/11 : 30:55 Program ver. 3.16, 03-08-d 

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment 

Code Grp Commodity Name (ppm) Ill 112 

---------- ------------------------------- ---------- ------- 1100007000 11 Apple, fruit with peel 0.010000 1.000 1.000 

1100008000 11 Apple, peel ed fruit 0 . 010000 1 . 000 1.000 

1100008001 11 Apple, peeled frui t-babyf ood 0 . 010000 1.000 1 . 000 

1100009000 11 Appl e, dried 0.010000 8.000 1.000 

1100009001 11 Apple, dried-babyfood 0 . 010000 8.000 1 . 000 

1100010000 11 Appl e , juice 0 . 010000 1. 300 l. 000 

1100010001 11 Apple, juic e-babyfood 0.010000 1.300 1.000 

1100011000 11 Apple, sauce 0 . 010000 1.000 1.000 

1100011001 11 Appl e, sauce-babyfood 0 . 010000 1.000 1.000 

1100129000 11 Crabapple 0.010000 1 . 000 1.000 

1100173500 11 Goji berry 0 . 010000 1.000 1.000 

1100210000 11 Loquat 0.010000 1.000 1.000 

1100266000 11 Pear 0 . 010000 1 . 000 1.000 

1100266001 11 Pear-babyf ood 0 . 010000 1.000 1.000 

1100267000 11 Pear, dried 0.010000 6.250 1.000 

1100268000 11 Pear, juice 0 . 010000 1.000 1. 000 

1100268001 11 Pear, juice-babyfood 0 . 010000 1 . 000 1 . 000 

1100310000 11 Quince 0.010000 l. 000 1 . 000 

1201090000 12A Cherry 0 . 010000 1.000 1.000 

1201090001 12A Cherry-babyf ood 0.010000 1.000 1 . 000 

1201091000 12A Cherry, JUI.Ce 0.010000 1. 500 1. 000 

1201091001 12A Cherry, juice-babyfood 0.010000 1.500 1.000 

1202012000 12B Apricot 0.010000 1.000 1.000 

1202012001 12B Apricot-babyfood 0 . 010000 1.000 1 . 000 

1202013000 126 Apri cot, dried 0 . 010000 6.000 1.000 

1202014000 126 Apricot, juice 0.010000 1.000 1.000 

1202014001 126 Apricot, juice-babyfood 0 . 010000 l. 000 1.000 

1202230000 126 Nectarine 0.010000 1 . 000 1. 000 

1202260000 128 Peach 0.010000 1.000 1.000 

1202260001 128 Peach-baby food 0.010000 1.000 1.000 

1202261000 128 Peach, dried 0 . 010000 7.000 1.000 

1202261001 128 Peach, dried-babyfood 0 . 010000 7.000 1.000 

1202262000 126 Peach, juice 0.010000 1.000 1.000 

1202262001 126 Peach, juice-babyfood 0.010000 1.000 1. 000 

1203285000 12C Plum 0 . 010000 1.000 1 . 000 

1203285001 12C Plum-babyfood 0.010000 1.000 1. 000 

1203286000 12C Plum, prune, fresh 0.010000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 0.010000 l. 000 1. 000 

1203287000 12C Plum, prune , dried 0.010000 5 . 000 1 . 000 

1203287001 12C Plum, prune, dried -babyfood 0.010000 5.000 1.000 

1203288000 12C Plum, prune, juice 0.010000 1.400 1.000 

1203288001 12C Plum, prune, juice-babyfood 0 . 010000 1.400 1. 000 

1302174 000 136 Gooseberry 0 . 010000 1. 000 1.000 

1304175000 130 Grape 0 . 010000 1.000 1.000 

1304176000 130 Grape, juice 0.010000 1.200 1.000 

1304176001 130 Grape , juice-babyfood 0 . 010000 1.200 1 . 000 

1304179000 130 Grape, wine and s h erry 0.010000 1.200 1.000 

1400003000 14 Almond 0 . 010000 1.000 1.000 

1400003001 14 Almond-babyfood 0 . 010000 1.000 1.000 

1400004000 14 Almond , oil 0.0 10000 1. 000 1. 000 

1400004001 14 Almond, oil-babyfood 0.010000 1.000 1.000 

1400059000 14 Brazil nut 0.010000 1.000 1.000 

1400068000 14 Butternut 0 . 010000 1 . 000 1.000 

1400081000 14 Cash ew 0 . 010000 1.000 1.000 

Page 7 of 10 
Penoxsulam ( 11903 I) Dietary Exposure and Risk Assessment DP Number: 4290 I 0 

1400092000 14 Chestnut 0 . 010000 1.000 1 . 000 

1400155000 14 Hazelnut 0 . 010000 1.000 1 . 000 

1400156000 14 Hazelnut, oil 0 . 010000 1.000 1.000 

1400185000 14 Hickory nut 0 . 010000 1.000 1.000 

1400213000 14 Macadamia nut 0 . 010000 1. 000 1.000 

1400269000 14 Pecan 0 . 010000 1.000 1 . 000 

1400278000 14 Pine nut 0 . 010000 1. 000 1.000 

1400282000 14 Pistachio 0 .010000 1.000 1.000 

1400391000 14 Walnut 0 . 010000 1 . 000 1 . 000 

1500323 000 15 Rice, whir.e 0 . 020000 1.000 1.000 

1500323001 15 Rice , white -babyfood 0 . 020000 1.000 1.000 

1500324000 1 5 Rice, brown 0 . 020000 1. 000 1. 000 

1500324001 15 Rice , brown-babyfood 0 . 020000 1 . 000 1 . 000 

1500325000 15 Rice , flour 0 .020000 1 . 000 1 . 000 

1500325001 15 Rice, flour-babyfood 0.020000 1. 000 1. 000 

1500326000 15 Rice, bran 0 . 0 20000 1. 000 1.000 

1500326001 15 Rice , bran-babyfood 0 . 020000 1.000 1 . 000 

1500405000 15 Wild rice 0.020000 1.000 1 . 000 

8000157000 80 Fish-freshwater finfish 0 . 014000 1.000 1. 000 

8000158000 80 Fish-freshwater finf ish, farm ra 0 . 014000 1 . 000 1.000 

8000161000 80 Fish-shellfish, crustacean 0 . 014000 1. 000 1.000 

8 000162000 80 Fish-shellfish, mollusc 0 . 028000 1 . 000 1.000 

8601000000 86A Water, direct, all sources 0.150000 1.000 1.000 

8602000000 86B war.er, indirect, all sources 0 .150000 1 . 000 1 . 000 

9500177000 0 Grape, leaves 0.010000 1. 000 1 . 000 

9500178000 0 Grape, raisin 0.010000 4.300 1 . 000 

9500235000 0 Olive 0 .010000 1.000 1 . 000 

9500236000 0 Olive, oil 0 . 010000 1 . 000 1 . 000 

9500289000 0 Pomegranate 0 . 010000 1.000 1 . 000 

Page 8 of10 
Penoxsulam ( 11 903 1) Dietary Exposure and Risk Assessment DP Number: 4290 I 0 

Attachment 2: Chronic Food plus Water Results File 

us EPA Ver. 3 . 16, 03-0B-d 

DEEM-FCID Chronic analysis for PENOXSULAM NHANES 2003-2008 2-day 

Residue file name : F : \penoxsulam\Dietary\ll903lC_090815.R08 

Adjustment factor #2 NOT used. 

Analysis Date 09-10-2015/11 : 48:49 Residue file dat ed : 09-10-2015/11:30 : 55 

Reference dose (RfD, Chronic) a .147 mg/kg bw/day 

== =============================== == === === == =~ ==== == === == === ================== 

Population 

Subgroup 

Total us Population 

Hispanic 

Non - Hisp -White 

Non- Hisp-Black 

Non-Hisp -Other 

Nursing Infants 

Non -Nursing Infants 

Female 13+ PREG 

Children 1-6 

Children 7-12 

Male 13-19 

Female 13-19/NP 

Male 20+ 

Female 20+/NP 

Seniors SS+ 

All Infants 

Female 13 - so 

Children 1-2 

Ch ildr en 3-S 

Children 6-12 

Youth 13 -19 

Adults 20 - 49 

Adults S0-99 

Female 13-49 

Total exposure by population subgro up 

Total Exposure 

mg/kg 

body wt/day 

0 . 003173 

0.003039 

0.003259 

0.00262S 

0.003669 

0. 002916 

0 . 010S91 

0.002981 

0.004lS8 

0.002658 

0.002l7S 

0. 002438 

0 . 002946 

0.003317 

0 . 0030S6 

0.008222 

0 . 003144 

0.004725 

0 . 003929 

0.002798 

0 . 002308 

0. 0031S3 

0. 003117 

0 . 003140 

Page 9 of I 0 

Percent of 

Rf d 

2 . 2% 

2 . 1% 

2 . 2% 

1. 8% 

2 . S% 

2 . 0% 

7 . 2% 

2 . 0% 

2 . 8 % 

1. 8% 

1. S% 

l . 7% 

2 . 0% 

2.3% 

2 . 1% 

5 . 6% 

2 . 1% 

3 . 2% 

2 . 7% 

1. 9% 

1.6% 

2 . 1% 

2.1% 

2 . 1% 
Penoxsu lam ( I 1903 I) Dietary Exposure and Risk Assessment DP umber: 429010 

Attachment 3: Chronic Food Only Results File 

us EPA Ver. 3 . 16 , 03 -08 - d 

DEEM-FCID Chronic analysis for PENOXSULAM NHANES 2003-2008 2-day 

Residue file name : F:\penoxsulam\Dietary\119031C_090815_noDW.R08 

Ad justment factor #2 NOT used . 

Analysis Date 09-10-2015/16 :23:21 Residue file dated: 09-10-2015/16 : 23 :05 

Reference dose (RfD , Chronic) = . 147 mg/kg bw/day 

Population 

Subgroup 

Total US Population 

Hispanic 

Non - Hisp- White 

Non-Hisp-Black 

Non-Hisp-Other 

Nursing Infants 

Non-Nursing Infants 

Female 13+ PREG 

Children 1-6 

Children 7-12 

Ma le 13-19 

Female 13-19/NP 

Ma le 20+ 

Female 20+/NP 

Seniors 55+ 

All Infants 

Female 13-50 

Children 1-2 

Children 3 - 5 

Children 6-12 

Youth 13-19 

Adults 20-49 

Adults 50-99 

Female 13-49 

Total exposure by population subgroup 

Total Exposure 

mg/kg 

body wt/day 

0.000032 

0.000040 

0.000029 

0 . 000034 

0 . 000048 

0.000075 

0 . 000145 

0.000024 

0. 000135 

0.000039 

0 . 000016 

0.000019 

0 . 000020 

0 . 000018 

0.000019 

0.000123 

0 . 000018 

0.000194 

0.000112 

0.000045 

0 . 000017 

0 . 000019 

0.000019 

0.000018 

Page 10of10 

Percent of 

Rfd 

0.0% 

0 . 0% 

0 . 0% 

0 . 0% 

0 . 0% 

0 . 1% 

0 . 1% 

0 . 0% 

0 . 1% 

0 . 0% 

0 . 0% 

0.0% 

0.0% 

0 . 0% 

0 . 0% 

0 . 1% 

0 . 0% 

0 . 1% 

0 . 1% 

0 . 0% 

0 . 0% 

0 . 0% 

0 . 0% 

0 . 0%