exv4w8



 







Exhibit 4.8




ANADYS PHARMACEUTICALS, INC.




and




                                        , As Warrant Agent




FORM OF PREFERRED STOCK

WARRANT AGREEMENT




Dated As Of                                                             




 









 






	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 	 	Page
	ARTICLE 1	 	 	 	ISSUANCE OF WARRANTS AND EXECUTION AND DELIVERY OF WARRANT CERTIFICATES	 	 	1	 
	 	 	 	1.1	 	 	Issuance of Warrants	 	 	1	 
	 	 	 	1.2	 	 	Execution and Delivery of Warrant Certificates	 	 	1	 
	 	 	 	1.3	 	 	Issuance of Warrant Certificates	 	 	2	 
	ARTICLE 2	 	 	 	WARRANT PRICE, DURATION AND EXERCISE OF WARRANTS	 	 	3	 
	 	 	 	2.1	 	 	Warrant Price	 	 	3	 
	 	 	 	2.2	 	 	Duration of Warrants	 	 	3	 
	 	 	 	2.3	 	 	Exercise of Warrants	 	 	3	 
	ARTICLE 3	 	 	 	OTHER PROVISIONS RELATING TO RIGHTS OF HOLDERS OF WARRANT CERTIFICATES	 	 	4	 
	 	 	 	3.1	 	 	No Rights as Warrant Securityholder Conferred by Warrants or Warrant

Certificates	 	 	4	 
	 	 	 	3.2	 	 	Lost, Stolen, Mutilated or Destroyed Warrant Certificates	 	 	4	 
	 	 	 	3.3	 	 	Holder of Warrant Certificate May Enforce Rights	 	 	5	 
	 	 	 	3.4	 	 	Adjustments	 	 	5	 
	 	 	 	3.5	 	 	Notice to Warrantholders	 	 	8	 
	 	 	 	3.6	 	 	[If the Warrants are subject to acceleration by the Company,
insert—Acceleration of Warrants by the Company	 	 	8	 
	ARTICLE 4	 	 	 	EXCHANGE AND TRANSFER OF WARRANT CERTIFICATES	 	 	9	 
	 	 	 	4.1	 	 	Exchange and Transfer of Warrant Certificates	 	 	9	 
	 	 	 	4.2	 	 	Treatment of Holders of Warrant Certificates	 	 	10	 
	 	 	 	4.3	 	 	Cancellation of Warrant Certificates	 	 	10	 
	ARTICLE 5	 	 	 	CONCERNING THE WARRANT AGENT	 	 	11	 
	 	 	 	5.1	 	 	Warrant Agent	 	 	11	 
	 	 	 	5.2	 	 	Conditions of Warrant Agent’s Obligations	 	 	11	 
	 	 	 	5.3	 	 	Resignation and Appointment of Successor	 	 	12	 
	ARTICLE 6	 	 	 	MISCELLANEOUS	 	 	14	 
	 	 	 	6.1	 	 	Amendment	 	 	14	 
	 	 	 	6.2	 	 	Notices and Demands to the Company and Warrant Agent	 	 	14	 
	 	 	 	6.3	 	 	Addresses	 	 	14	 






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	 	 	 	 	Table of Contents

(CONTINUED)	 	 	 	 
	 	 	 	 	 	 	 	 	 	 	Page
	 	 	 	6.4	 	 	Governing Law	 	 	14	 
	 	 	 	6.5	 	 	Delivery of Prospectus	 	 	14	 
	 	 	 	6.6	 	 	Obtaining of Governmental Approvals	 	 	14	 
	 	 	 	6.7	 	 	Persons Having Rights Under Warrant Agreement	 	 	14	 
	 	 	 	6.8	 	 	Headings	 	 	15	 
	 	 	 	6.9	 	 	Counterparts	 	 	15	 
	 	 	 	6.10	 	 	Inspection of Agreement	 	 	15	 







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ANADYS PHARMACEUTICALS, INC.

Form of Preferred Stock Warrant Agreement




          Preferred Stock Warrant Agreement, dated as of                      between Anadys
Pharmaceuticals, Inc., a Delaware corporation (the “Company”) and                                         , a
[corporation] [national banking association] organized and existing under the laws of                                         
and having a corporate trust office in                                         , as warrant agent (the “Warrant Agent”).




          Whereas, the Company proposes to sell [if Warrants are sold with other securities -
[title of such other securities being offered] (the “Other Securities”) with] warrant certificates
evidencing one or more warrants (the “Warrants” or, individually, a “Warrant”) representing the
right to purchase [title of Preferred Stock purchasable through exercise of Warrants] (the “Warrant
Securities”), such warrant certificates and other warrant certificates issued pursuant to this
Agreement being herein called the “Warrant Certificates”; and




          Whereas, the Company desires the Warrant Agent to act on behalf of the Company, and
the Warrant Agent is willing so to act, in connection with the issuance, registration, transfer,
exchange, exercise and replacement of the Warrant Certificates, and in this Agreement wishes to set
forth, among other things, the form and provisions of the Warrant Certificates and the terms and
conditions on which they may be issued, registered, transferred, exchanged, exercised and replaced;




          Now Therefore, in consideration of the premises and of the mutual agreements herein
contained, the parties hereto agree as follows:




ARTICLE 1




ISSUANCE OF WARRANTS AND EXECUTION AND

DELIVERY OF WARRANT CERTIFICATES




          1.1 Issuance of Warrants. [If Warrants alone — Upon issuance, each Warrant Certificate shall
evidence one or more Warrants.] [If Other Securities and Warrants — Warrants shall be [initially]
issued in connection with the issuance of the Other Securities [but shall be separately
transferable on and after                                                              (the “Detachable Date”)] [and shall
not be separately transferable] and each Warrant Certificate shall evidence one or more Warrants.]
Each Warrant evidenced thereby shall represent the right, subject to the provisions contained
herein and therein, to purchase one Warrant Security. [If Other Securities and Warrants — Warrant
Certificates shall be initially issued in units with the Other Securities and each Warrant
Certificate included in such a unit shall evidence                                          Warrants for each [$                                        
principal amount] [                     shares] of Other Securities included in such unit.]




          1.2 Execution and Delivery of Warrant Certificates. Each Warrant Certificate, whenever
issued, shall be in registered form substantially in the form set forth in Exhibit A hereto, shall
be dated the date of its countersignature by the Warrant Agent and may have such

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letters, numbers, or other marks of identification or designation and such legends or
endorsements printed, lithographed or engraved thereon as the officers of the Company executing the
same may approve (execution thereof to be conclusive evidence of such approval) and as are not
inconsistent with the provisions of this Agreement, or as may be required to comply with any law or
with any rule or regulation made pursuant thereto or with any rule or regulation of any securities
exchange on which the Warrants may be listed, or to conform to usage. The Warrant Certificates
shall be signed on behalf of the Company by any of its present or future chief executive officers,
presidents, senior vice presidents, vice presidents, chief financial officers, chief legal
officers, treasurers, assistant treasurers, controllers, assistant controllers, secretaries or
assistant secretaries under its corporate seal reproduced thereon. Such signatures may be manual
or facsimile signatures of such authorized officers and may be imprinted or otherwise reproduced on
the Warrant Certificates. The seal of the Company may be in the form of a facsimile thereof and
may be impressed, affixed, imprinted or otherwise reproduced on the Warrant Certificates.




          No Warrant Certificate shall be valid for any purpose, and no Warrant evidenced thereby shall
be exercisable, until such Warrant Certificate has been countersigned by the manual signature of
the Warrant Agent. Such signature by the Warrant Agent upon any Warrant Certificate executed by
the Company shall be conclusive evidence that the Warrant Certificate so countersigned has been
duly issued hereunder.




          In case any officer of the Company who shall have signed any of the Warrant Certificates
either manually or by facsimile signature shall cease to be such officer before the Warrant
Certificates so signed shall have been countersigned and delivered by the Warrant Agent, such
Warrant Certificates may be countersigned and delivered notwithstanding that the person who signed
Warrant Certificates ceased to be such officer of the Company; and any Warrant Certificate may be
signed on behalf of the Company by such persons as, at the actual date of the execution of such
Warrant Certificate, shall be the proper officers of the Company, although at the date of the
execution of this Agreement any such person was not such officer.




          The term “holder” or “holder of a Warrant Certificate” as used herein shall mean any person in
whose name at the time any Warrant Certificate shall be registered upon the books to be maintained
by the Warrant Agent for that purpose [If Other Securities and Warrants are not immediately
detachable — or upon the registration of the Other Securities prior to the Detachable Date. Prior
to the Detachable Date, the Company will, or will cause the registrar of the Other Securities to,
make available at all times to the Warrant Agent such information as to holders of the Other
Securities as may be necessary to keep the Warrant Agent’s records up to date].




          1.3 Issuance of Warrant Certificates. Warrant Certificates evidencing the right to purchase
Warrant Securities may be executed by the Company and delivered to the Warrant Agent upon the
execution of this Warrant Agreement or from time to time thereafter. The Warrant Agent shall, upon
receipt of Warrant Certificates duly executed on behalf of the Company, countersign such Warrant
Certificates and shall deliver such Warrant Certificates to or upon the order of the Company.




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ARTICLE 2




WARRANT PRICE, DURATION AND EXERCISE OF WARRANTS




          2.1 Warrant Price. During the period specified in Section 2.2, each Warrant shall, subject to
the terms of this Warrant Agreement and the applicable Warrant Certificate, entitle the holder
thereof to purchase the number of Warrant Securities specified in the applicable Warrant
Certificate at an exercise price of $                     per Warrant Security, subject to adjustment upon the
occurrence of certain events, as hereinafter provided. Such purchase price per Warrant Security is
referred to in this Agreement as the “Warrant Price.”




          2.2 Duration of Warrants. Each Warrant may be exercised in whole or in part at any time, as
specified herein, on or after [the date thereof] [                                        ] and at or before [                                        ] p.m.,
[City] time, on                                          or such later date as the Company may designate by notice to the Warrant
Agent and the holders of Warrant Certificates mailed to their addresses as set forth in the record
books of the Warrant Agent (the “Expiration Date”). Each Warrant not exercised at or before
[                                        ] p.m., [City] time, on the Expiration Date shall become void, and all rights of the
holder of the Warrant Certificate evidencing such Warrant under this Agreement shall cease.




          2.3 Exercise of Warrants.




               (a) During the period specified in Section 2.2, the Warrants may be exercised to purchase a
whole number of Warrant Securities in registered form by providing certain information as set forth
on the reverse side of the Warrant Certificate and by paying in full, in lawful money of the United
States of America, [in cash or by certified check or official bank check in New York Clearing House
funds] [by bank wire transfer in immediately available funds] the Warrant Price for each Warrant
Security with respect to which a Warrant is being exercised to the Warrant Agent at its corporate
trust office, provided that such exercise is subject to receipt within five business days of such
payment by the Warrant Agent of the Warrant Certificate with the form of election to purchase
Warrant Securities set forth on the reverse side of the Warrant Certificate properly completed and
duly executed. The date on which payment in full of the Warrant Price is received by the Warrant
Agent shall, subject to receipt of the Warrant Certificate as aforesaid, be deemed to be the date
on which the Warrant is exercised; provided, however, that if, at the date of receipt of such
Warrant Certificates and payment in full of the Warrant Price, the transfer books for the Warrant
Securities purchasable upon the exercise of such Warrants shall be closed, no such receipt of such
Warrant Certificates and no such payment of such Warrant Price shall be effective to constitute the
person so designated to be named as the holder of record of such Warrant Securities on such date,
but shall be effective to constitute such person as the holder of record of such Warrant Securities
for all purposes at the opening of business on the next succeeding day on which the transfer books
for the Warrant Securities purchasable upon the exercise of such Warrants shall be opened, and the
certificates for the Warrant Securities in respect of which such Warrants are then exercised shall
be issuable as of the date on such next succeeding day on which the transfer books shall next be
opened, and until such date the Company shall be under no duty to deliver any certificate for such
Warrant Securities. The Warrant Agent shall deposit all funds received by it in payment of the
Warrant Price in an account of the Company maintained with it and shall advise the Company by



3









 







telephone at the end of each day on which a payment for the exercise of Warrants is received
of the amount so deposited to its account. The Warrant Agent shall promptly confirm such telephone
advice to the Company in writing.



               (b) The Warrant Agent shall, from time to time, as promptly as practicable, advise the Company
of (i) the number of Warrant Securities with respect to which Warrants were exercised, (ii) the
instructions of each holder of the Warrant Certificates evidencing such Warrants with respect to
delivery of the Warrant Securities to which such holder is entitled upon such exercise, (iii)
delivery of Warrant Certificates evidencing the balance, if any, of the Warrants for the remaining
Warrant Securities after such exercise, and (iv) such other information as the Company shall
reasonably require.



               (c) As soon as practicable after the exercise of any Warrant, the Company shall issue to or
upon the order of the holder of the Warrant Certificate evidencing such Warrant the Warrant
Securities to which such holder is entitled, in fully registered form, registered in such name or
names as may be directed by such holder. If fewer than all of the Warrants evidenced by such
Warrant Certificate are exercised, the Company shall execute, and an authorized officer of the
Warrant Agent shall manually countersign and deliver, a new Warrant Certificate evidencing Warrants
for the number of Warrant Securities remaining unexercised.



               (d) The Company shall not be required to pay any stamp or other tax or other governmental
charge required to be paid in connection with any transfer involved in the issue of the Warrant
Securities, and in the event that any such transfer is involved, the Company shall not be required
to issue or deliver any Warrant Security until such tax or other charge shall have been paid or it
has been established to the Company’s satisfaction that no such tax or other charge is due.



               (e) Prior to the issuance of any Warrants there shall have been reserved, and the Company
shall at all times through the Expiration Date keep reserved, out of its authorized but unissued
Warrant Securities, a number of shares sufficient to provide for the exercise of the Warrants.



ARTICLE 3




OTHER PROVISIONS RELATING TO RIGHTS

OF HOLDERS OF WARRANT CERTIFICATES




          3.1 No Rights as Warrant Securityholder Conferred by Warrants or Warrant Certificates. No
Warrant Certificate or Warrant evidenced thereby shall entitle the holder thereof to any of the
rights of a holder of Warrant Securities, including, without limitation, the right to receive the
payment of dividends or distributions, if any, on the Warrant Securities or to exercise any voting
rights, except to the extent expressly set forth in this Agreement or the applicable Warrant
Certificate.




          3.2 Lost, Stolen, Mutilated or Destroyed Warrant Certificates. Upon receipt by the Warrant
Agent of evidence reasonably satisfactory to it and the Company of the ownership of and the loss,
theft, destruction or mutilation of any Warrant Certificate and/or indemnity

4









 








reasonably satisfactory to the Warrant Agent and the Company and, in the case of mutilation,
upon surrender of the mutilated Warrant Certificate to the Warrant Agent for cancellation, then, in
the absence of notice to the Company or the Warrant Agent that such Warrant Certificate has been
acquired by a bona fide purchaser, the Company shall execute, and an authorized officer of the
Warrant Agent shall manually countersign and deliver, in exchange for or in lieu of the lost,
stolen, destroyed or mutilated Warrant Certificate, a new Warrant Certificate of the same tenor and
evidencing Warrants for a like number of Warrant Securities. Upon the issuance of any new Warrant
Certificate under this Section 3.2, the Company may require the payment of a sum sufficient to
cover any tax or other governmental charge that may be imposed in relation thereto and any other
expenses (including the fees and expenses of the Warrant Agent) in connection therewith. Every
substitute Warrant Certificate executed and delivered pursuant to this Section 3.2 in lieu of any
lost, stolen or destroyed Warrant Certificate shall represent an additional contractual obligation
of the Company, whether or not the lost, stolen or destroyed Warrant Certificate shall be at any
time enforceable by anyone, and shall be entitled to the benefits of this Agreement equally and
proportionately with any and all other Warrant Certificates duly executed and delivered hereunder.
The provisions of this Section 3.2 are exclusive and shall preclude (to the extent lawful) all
other rights and remedies with respect to the replacement of mutilated, lost, stolen or destroyed
Warrant Certificates.




          3.3 Holder of Warrant Certificate May Enforce Rights. Notwithstanding any of the provisions
of this Agreement, any holder of a Warrant Certificate, without the consent of the Warrant Agent,
the holder of any Warrant Securities or the holder of any other Warrant Certificate, may, in such
holder’s own behalf and for such holder’s own benefit, enforce, and may institute and maintain any
suit, action or proceeding against the Company suitable to enforce, or otherwise in respect of,
such holder’s right to exercise the Warrants evidenced by such holder’s Warrant Certificate in the
manner provided in such holder’s Warrant Certificate and in this Agreement.




          3.4 Adjustments.




               (a) In case the Company shall at any time subdivide its outstanding shares of [title of
Preferred Stock purchasable through exercise of Warrants] into a greater number of shares, the
Warrant Price in effect immediately prior to such subdivision shall be proportionately reduced and
the number of Warrant Securities purchasable under the Warrants shall be proportionately increased.
Conversely, in case the outstanding shares of [title of Preferred Stock purchasable through
exercise of Warrants] of the Company shall be combined into a smaller number of shares, the Warrant
Price in effect immediately prior to such combination shall be proportionately increased and the
number of Warrant Securities purchasable under the Warrants shall be proportionately decreased.



               (b) If at any time or from time to time the holders of [title of Preferred Stock purchasable
through exercise of Warrants] (or any shares of stock or other securities at the time receivable
upon the exercise of the Warrants) shall have received or become entitled to receive, without
payment therefore,



                    (i) [title of Preferred Stock purchasable through exercise of Warrants] or any shares of stock
or other securities which are at any time directly or indirectly convertible



5









 







into or exchangeable for [title of Preferred Stock purchasable through exercise of Warrants],
or any rights or options to subscribe for, purchase or otherwise acquire any of the foregoing by
way of dividend or other distribution;



                    (ii) any cash paid or payable otherwise than in accordance with the terms of [title of
Preferred Stock purchasable through exercise of Warrants] or otherwise than as a cash dividend paid
or payable out of the Company’s current or retained earnings;



                    (iii) any evidence of the Company’s indebtedness or rights to subscribe for or purchase the
Company’s indebtedness; or



                    (iv) [title of Preferred Stock purchasable through exercise of Warrants] or additional stock
or other securities or property (including cash) by way of spinoff, split-up, reclassification,
combination of shares or similar corporate rearrangement (other than shares of [title of Preferred
Stock purchasable through exercise of Warrants] issued as a stock split or adjustments in respect
of which shall be covered by the terms of Section 3.4(a) above),


then and in each such case, the holder of each Warrant shall, upon the exercise of the Warrant, be
entitled to receive, in addition to the number of Warrant Securities receivable thereupon, and
without payment of any additional consideration therefore, the amount of stock and other securities
and property (including cash and indebtedness (or rights to subscribe for or purchase indebtedness)
which such holder would hold on the date of such exercise had he been the holder of record of such
Warrant Securities as of the date on which holders of [title of Preferred Stock purchasable through
exercise of Warrants] received or became entitled to receive such shares or all other additional
stock and other securities and property.




               (c) In case of (i) any reclassification, capital reorganization, or change in the [title of
Preferred Stock purchasable through the exercise of the Warrants] of the Company (other than as a
result of a subdivision, combination or stock dividend provided for in Section 3.4(a) or Section
3.4(b) above), (ii) share exchange, merger or similar transaction of the Company with or into
another person or entity (other than a share exchange, merger or similar transaction in which the
Company is the acquiring or surviving corporation and which does not result in any change in the
[title of Preferred Stock purchasable through the exercise of the Warrants] other than the issuance
of additional shares of [title of Preferred Stock purchasable through the exercise of the
Warrants]) or (iii) the sale, exchange, lease, transfer or other disposition of all or
substantially all of the properties and assets of the Company as an entirety (in any such case, a
“Reorganization Event”), then, as a condition of such Reorganization Event, lawful provisions shall
be made, and duly executed documents evidencing the same from the Company or its successor shall be
delivered to the holders of the Warrants, so that the holders of the Warrants shall have the right
at any time prior to the expiration of the Warrants to purchase, at a total price equal to that
payable upon the exercise of the Warrants, the kind and amount of shares of stock and other
securities and property receivable in connection with such Reorganization Event by a holder of the
same number of shares of [title of Preferred Stock purchasable through the exercise of the
Warrants] as were purchasable by the holders of the Warrants immediately prior to such
Reorganization Event. In any such case appropriate provisions shall be made with respect to the
rights and interests of the holders of the Warrants so that the provisions hereof shall thereafter
be applicable with respect to any shares of stock or other securities and property deliverable upon



6









 







exercise the Warrants, and appropriate adjustments shall be made to the Warrant Price payable
hereunder provided the aggregate purchase price shall remain the same. In the case of any
transaction described in clauses (ii) and (iii) above, the Company shall thereupon be relieved of
any further obligation hereunder or under the Warrants, and the Company as the predecessor
corporation may thereupon or at any time thereafter be dissolved, wound up or liquidated. Such
successor or assuming entity thereupon may cause to be signed, and may issue either in its own name
or in the name of the Company, any or all of the Warrants issuable hereunder which heretofore shall
not have been signed by the Company, and may execute and deliver securities in its own name, in
fulfillment of its obligations to deliver Warrant Securities upon exercise of the Warrants. All
the Warrants so issued shall in all respects have the same legal rank and benefit under this
Agreement as the Warrants theretofore or thereafter issued in accordance with the terms of this
Agreement as though all of such Warrants had been issued at the date of the execution hereof. In
any case of any such Reorganization Event, such changes in phraseology and form (but not in
substance) may be made in the Warrants thereafter to be issued as may be appropriate.



          The Warrant Agent may receive a written opinion of legal counsel as conclusive evidence that
any such Reorganization Event complies with the provisions of this Section 3.4.




               (d) The Company may, at its option, at any time until the Expiration Date, reduce the then
current Warrant Price to any amount deemed appropriate by the Board of Directors of the Company for
any period not exceeding twenty consecutive days (as evidenced in a resolution adopted by such
Board of Directors), but only upon giving the notices required by Section 3.5 at least ten days
prior to taking such action.



               (e) Except as herein otherwise expressly provided, no adjustment in the Warrant Price shall be
made by reason of the issuance of any securities of the Company or for any other reason whatsoever.



               (f) No fractional Warrant Securities shall be issued upon the exercise of Warrants. If more
than one Warrant shall be exercised at one time by the same holder, the number of full Warrant
Securities which shall be issuable upon such exercise shall be computed on the basis of the
aggregate number of Warrant Securities purchased pursuant to the Warrants so exercised. Instead of
any fractional Warrant Security which would otherwise be issuable upon exercise of any Warrant, the
Company shall pay a cash adjustment in respect of such fraction in an amount equal to the same
fraction of the last sales price (or bid price if there were no sales) per Warrant Security, in
either case as reported on the New York Stock Exchange Composite Tape on the business day which
next precedes the day of exercise or, if the Warrant Securities are not then listed or admitted to
trading on the New York Stock Exchange, on the principal national securities exchange on which the
Warrant Securities are listed or admitted to trading or, if not listed or admitted to trading on
any national securities exchange, Nasdaq Stock Market, or if the Warrant Securities are not then
listed or admitted to trading on any national securities exchange or quoted on the Nasdaq Stock
Market, the average of the closing high bid and low asked prices in the over-the-counter market, as
reported by The Nasdaq Stock Market, Inc. or the National Association of Securities Dealers, Inc.,
as applicable (“NASDAQ”), or such other system then in use, or if on any such date the Warrant
Securities are not quoted by any such organization, an amount equal to the same fraction of the
average of the closing bid and asked



7









 







prices as furnished by any New York Stock Exchange firm selected from time to time by the
Company for that purpose at the close of business on the business day which next precedes the day
of exercise.



               (g) Whenever the Warrant Price then in effect is adjusted as herein provided, the Company
shall mail to each holder of the Warrants at such holder’s address as it shall appear on the books
of the Company a statement setting forth the adjusted Warrant Price then and thereafter effective
under the provisions hereof, together with the facts, in reasonable detail, upon which such
adjustment is based.



          3.5 Notice to Warrantholders. In case the Company shall (a) effect any dividend or
distribution described in Section 3.4(b), (b) effect any Reorganization Event, (c) make any
distribution on or in respect of the [title of Preferred Stock purchasable through the exercise of
the Warrants] in connection with the dissolution, liquidation or winding up of the Company, or (d)
reduce the then current Warrant Price pursuant to Section 3.4(d), then the Company shall mail to
each holder of Warrants at such holder’s address as it shall appear on the books of the Warrant
Agent, at least ten days prior to the applicable date hereinafter specified, a notice stating (x)
the record date for such dividend or distribution, or, if a record is not to be taken, the date as
of which the holders of record of [title of Preferred Stock purchasable through the exercise of
Warrants] that will be entitled to such dividend or distribution are to be determined, (y) the date
on which such Reorganization Event, dissolution, liquidation or winding up is expected to become
effective, and the date as of which it is expected that holders of [title of Preferred Stock
purchasable through the exercise of the Warrants] of record shall be entitled to exchange their
shares of [title of Preferred Stock purchasable through the exercise of the Warrants] for
securities or other property deliverable upon such Reorganization Event, dissolution, liquidation
or winding up, or (z) the first date on which the then current Warrant Price shall be reduced
pursuant to Section 3.4(d). No failure to mail such notice nor any defect therein or in the
mailing thereof shall affect any such transaction or any adjustment in the Warrant Price required
by Section 3.4.




          3.6 [If the Warrants are subject to acceleration by the Company, insert—Acceleration of
Warrants by the Company.




               (a) At any time on or after                                         , the Company shall have the right to accelerate any or
all Warrants at any time by causing them to expire at the close of business on the day next
preceding a specified date (the “Acceleration Date”), if the Market Price (as hereinafter defined)
of the [title of Preferred Stock purchasable through the exercise of the Warrants] equals or
exceeds                                          percent (                    %) of the then effective Warrant Price on any twenty Trading
Days (as hereinafter defined) within a period of thirty consecutive Trading Days ending no more
than five Trading Days prior to the date on which the Company gives notice to the Warrant Agent of
its election to accelerate the Warrants.



               (b) “Market Price” for each Trading Day shall be, if the [title of Preferred Stock purchasable
through the exercise of the Warrants] is listed or admitted for trading on the New York Stock
Exchange, the last reported sale price, regular way (or, if no such price is reported, the average
of the reported closing bid and asked prices, regular way) of [title of Preferred Stock purchasable
through the exercise of the Warrants], in either case as reported on



8









 







the New York Stock Exchange Composite Tape or, if the [title of Preferred Stock purchasable
through the exercise of the Warrants] is not listed or admitted to trading on the New York Stock
Exchange, on the principal national securities exchange on which the [title of Preferred Stock
purchasable through the exercise of the Warrants] is listed or admitted to trading or, if not
listed or admitted to trading on any national securities exchange, on the Nasdaq Stock Market or,
if not listed or admitted to trading on any national securities exchange or quoted on the Nasdaq
Stock Market, the average of the closing high bid and low asked prices in the over-the-counter
market, as reported by NASDAQ, or such other system then in use, or if on any such date the shares
of [title of Preferred Stock purchasable through the exercise of the Warrants] are not quoted by
any such organization, the average of the closing bid and asked prices as furnished by any New York
Stock Exchange firm selected from time to time by the Company for that purpose. “Trading Day”
shall be each Monday through Friday, other than any day on which securities are not traded in the
system or on the exchange that is the principal market for the [title of Preferred Stock
purchasable through the exercise of the Warrants], as determined by the Board of Directors of the
Company.



               (c) In the event of an acceleration of less than all of the Warrants, the Warrant Agent shall
select the Warrants to be accelerated by lot, pro rata or in such other manner as it deems, in its
discretion, to be fair and appropriate.



               (d) Notice of an acceleration specifying the Acceleration Date shall be sent by mail first
class, postage prepaid, to each registered holder of a Warrant Certificate representing a Warrant
accelerated at such holder’s address appearing on the books of the Warrant Agent not more than
sixty days nor less than thirty days before the Acceleration Date. Such notice of an acceleration
also shall be given no more than twenty days, and no less than ten days, prior to the mailing of
notice to registered holders of Warrants pursuant to this Section 3.6, by publication at least once
in a newspaper of general circulation in the City of New York.



               (e) Any Warrant accelerated may be exercised until [                    ] p.m., [City] time, on the business
day next preceding the Acceleration Date. The Warrant Price shall be payable as provided in
Section 2.]



ARTICLE 4




EXCHANGE AND TRANSFER OF WARRANT CERTIFICATES




          4.1 Exchange and Transfer of Warrant Certificates. [If Other Securities with Warrants which
are immediately detachable — Upon] [If Other Securities with Warrants which are not immediately
detachable — Prior to the Detachable Date, a Warrant Certificate may be exchanged or transferred
only together with the Other Security to which the Warrant Certificate was initially attached, and
only for the purpose of effecting or in conjunction with an exchange or transfer of such Other
Security. Prior to any Detachable Date, each transfer of the Other Security shall operate also to
transfer the related Warrant Certificates. After the Detachable Date, upon] surrender at the
corporate trust office of the Warrant Agent, Warrant Certificates evidencing Warrants may be
exchanged for Warrant Certificates in other denominations evidencing such Warrants or the transfer
thereof may be registered in whole or in part; provided that such other Warrant Certificates
evidence Warrants for the same aggregate number of

9









 








Warrant Securities as the Warrant Certificates so surrendered. The Warrant Agent shall keep,
at its corporate trust office, books in which, subject to such reasonable regulations as it may
prescribe, it shall register Warrant Certificates and exchanges and transfers of outstanding
Warrant Certificates, upon surrender of the Warrant Certificates to the Warrant Agent at its
corporate trust office for exchange or registration of transfer, properly endorsed or accompanied
by appropriate instruments of registration of transfer and written instructions for transfer, all
in form satisfactory to the Company and the Warrant Agent. No service charge shall be made for any
exchange or registration of transfer of Warrant Certificates, but the Company may require payment
of a sum sufficient to cover any stamp or other tax or other governmental charge that may be
imposed in connection with any such exchange or registration of transfer. Whenever any Warrant
Certificates are so surrendered for exchange or registration of transfer, an authorized officer of
the Warrant Agent shall manually countersign and deliver to the person or persons entitled thereto
a Warrant Certificate or Warrant Certificates duly authorized and executed by the Company, as so
requested. The Warrant Agent shall not be required to effect any exchange or registration of
transfer which will result in the issuance of a Warrant Certificate evidencing a Warrant for a
fraction of a Warrant Security or a number of Warrants for a whole number of Warrant Securities and
a fraction of a Warrant Security. All Warrant Certificates issued upon any exchange or
registration of transfer of Warrant Certificates shall be the valid obligations of the Company,
evidencing the same obligations and entitled to the same benefits under this Agreement as the
Warrant Certificate surrendered for such exchange or registration of transfer.




          4.2 Treatment of Holders of Warrant Certificates. [If Other Securities and Warrants are not
immediately detachable — Prior to the Detachable Date, the Company, the Warrant Agent and all other
persons may treat the owner of the Other Security as the owner of the Warrant Certificates
initially attached thereto for any purpose and as the person entitled to exercise the rights
represented by the Warrants evidenced by such Warrant Certificates, any notice to the contrary
notwithstanding. After the Detachable Date and prior to due presentment of a Warrant Certificate
for registration of transfer, the] [T]he Company, the Warrant Agent and all other persons may
treat the registered holder of a Warrant Certificate as the absolute owner thereof for any purpose
and as the person entitled to exercise the rights represented by the Warrants evidenced thereby,
any notice to the contrary notwithstanding.




          4.3 Cancellation of Warrant Certificates. Any Warrant Certificate surrendered for exchange,
registration of transfer or exercise of the Warrants evidenced thereby shall, if surrendered to the
Company, be delivered to the Warrant Agent and all Warrant Certificates surrendered or so delivered
to the Warrant Agent shall be promptly canceled by the Warrant Agent and shall not be reissued and,
except as expressly permitted by this Agreement, no Warrant Certificate shall be issued hereunder
in exchange therefor or in lieu thereof. The Warrant Agent shall deliver to the Company from time
to time or otherwise dispose of canceled Warrant Certificates in a manner satisfactory to the
Company.




ARTICLE 5




CONCERNING THE WARRANT AGENT




          5.1 Warrant Agent. The Company hereby appoints                                          as Warrant Agent of the Company
in respect of the Warrants and the Warrant Certificates upon the terms




10









 







and subject to the conditions herein set forth, and                                          hereby accepts such
appointment. The Warrant Agent shall have the powers and authority granted to and conferred upon
it in the Warrant Certificates and hereby and such further powers and authority to act on behalf of
the Company as the Company may hereafter grant to or confer upon it. All of the terms and
provisions with respect to such powers and authority contained in the Warrant Certificates are
subject to and governed by the terms and provisions hereof.




          5.2 Conditions of Warrant Agent’s Obligations. The Warrant Agent accepts its obligations
herein set forth upon the terms and conditions hereof, including the following to all of which the
Company agrees and to all of which the rights hereunder of the holders from time to time of the
Warrant Certificates shall be subject:




               (a) Compensation and Indemnification. The Company agrees promptly to pay the Warrant Agent
the compensation to be agreed upon with the Company for all services rendered by the Warrant Agent
and to reimburse the Warrant Agent for reasonable out-of-pocket expenses (including reasonable
counsel fees) incurred without negligence, bad faith or willful misconduct by the Warrant Agent in
connection with the services rendered hereunder by the Warrant Agent. The Company also agrees to
indemnify the Warrant Agent for, and to hold it harmless against, any loss, liability or expense
incurred without negligence, bad faith or willful misconduct on the part of the Warrant Agent,
arising out of or in connection with its acting as Warrant Agent hereunder, including the
reasonable costs and expenses of defending against any claim of such liability.



               (b) Agent for the Company. In acting under this Warrant Agreement and in connection with the
Warrant Certificates, the Warrant Agent is acting solely as agent of the Company and does not
assume any obligations or relationship of agency or trust for or with any of the holders of Warrant
Certificates or beneficial owners of Warrants.



               (c) Counsel. The Warrant Agent may consult with counsel satisfactory to it, which may include
counsel for the Company, and the written advice of such counsel shall be full and complete
authorization and protection in respect of any action taken, suffered or omitted by it hereunder in
good faith and in accordance with the advice of such counsel.



               (d) Documents. The Warrant Agent shall be protected and shall incur no liability for or in
respect of any action taken or omitted by it in reliance upon any Warrant Certificate, notice,
direction, consent, certificate, affidavit, statement or other paper or document reasonably
believed by it to be genuine and to have been presented or signed by the proper parties.



               (e) Certain Transactions. The Warrant Agent, and its officers, directors and employees, may
become the owner of, or acquire any interest in, Warrants, with the same rights that it or they
would have if it were not the Warrant Agent hereunder, and, to the extent permitted by applicable
law, it or they may engage or be interested in any financial or other transaction with the Company
and may act on, or as depositary, trustee or agent for, any committee or body of holders of Warrant
Securities or other obligations of the Company as freely as if it were not the Warrant Agent
hereunder. Nothing in this Warrant Agreement shall



11









 







be deemed to prevent the Warrant Agent from acting as trustee under any indenture to which the
Company is a party.



               (f) No Liability for Interest. Unless otherwise agreed with the Company, the Warrant Agent
shall have no liability for interest on any monies at any time received by it pursuant to any of
the provisions of this Agreement or of the Warrant Certificates.



               (g) No Liability for Invalidity. The Warrant Agent shall have no liability with respect to
any invalidity of this Agreement or any of the Warrant Certificates (except as to the Warrant
Agent’s countersignature thereon).



               (h) No Responsibility for Representations. The Warrant Agent shall not be responsible for any
of the recitals or representations herein or in the Warrant Certificates (except as to the Warrant
Agent’s countersignature thereon), all of which are made solely by the Company.



               (i) No Implied Obligations. The Warrant Agent shall be obligated to perform only such duties
as are herein and in the Warrant Certificates specifically set forth and no implied duties or
obligations shall be read into this Agreement or the Warrant Certificates against the Warrant
Agent. The Warrant Agent shall not be under any obligation to take any action hereunder which may
tend to involve it in any expense or liability, the payment of which within a reasonable time is
not, in its reasonable opinion, assured to it. The Warrant Agent shall not be accountable or under
any duty or responsibility for the use by the Company of any of the Warrant Certificates
authenticated by the Warrant Agent and delivered by it to the Company pursuant to this Agreement or
for the application by the Company of the proceeds of the Warrant Certificates. The Warrant Agent
shall have no duty or responsibility in case of any default by the Company in the performance of
its covenants or agreements contained herein or in the Warrant Certificates or in the case of the
receipt of any written demand from a holder of a Warrant Certificate with respect to such default,
including, without limiting the generality of the foregoing, any duty or responsibility to initiate
or attempt to initiate any proceedings at law or otherwise or, except as provided in Section 6.2
hereof, to make any demand upon the Company.



          5.3 Resignation and Appointment of Successor.




               (a) The Company agrees, for the benefit of the holders from time to time of the Warrant
Certificates, that there shall at all times be a Warrant Agent hereunder until all the Warrants
have been exercised or are no longer exercisable.



               (b) The Warrant Agent may at any time resign as agent by giving written notice to the Company
of such intention on its part, specifying the date on which its desired resignation shall become
effective; provided that such date shall not be less than three months after the date on which such
notice is given unless the Company otherwise agrees. The Warrant Agent hereunder may be removed at
any time by the filing with it of an instrument in writing signed by or on behalf of the Company
and specifying such removal and the intended date when it shall become effective. Such resignation
or removal shall take effect upon the appointment by the Company, as hereinafter provided, of a
successor Warrant Agent (which shall be a bank or trust company authorized under the laws of the
jurisdiction of its organization to exercise



12









 







corporate trust powers) and the acceptance of such appointment by such successor Warrant
Agent. The obligation of the Company under Section 5.2(a) shall continue to the extent set forth
therein notwithstanding the resignation or removal of the Warrant Agent.



               (c) In case at any time the Warrant Agent shall resign, or shall be removed, or shall become
incapable of acting, or shall be adjudged a bankrupt or insolvent, or shall commence a voluntary
case under the Federal bankruptcy laws, as now or hereafter constituted, or under any other
applicable Federal or state bankruptcy, insolvency or similar law or shall consent to the
appointment of or taking possession by a receiver, custodian, liquidator, assignee, trustee,
sequestrator (or other similar official) of the Warrant Agent or its property or affairs, or shall
make an assignment for the benefit of creditors, or shall admit in writing its inability to pay its
debts generally as they become due, or shall take corporate action in furtherance of any such
action, or a decree or order for relief by a court having jurisdiction in the premises shall have
been entered in respect of the Warrant Agent in an involuntary case under the Federal bankruptcy
laws, as now or hereafter constituted, or any other applicable Federal or state bankruptcy,
insolvency or similar law, or a decree or order by a court having jurisdiction in the premises
shall have been entered for the appointment of a receiver, custodian, liquidator, assignee,
trustee, sequestrator (or similar official) of the Warrant Agent or of its property or affairs, or
any public officer shall take charge or control of the Warrant Agent or of its property or affairs
for the purpose of rehabilitation, conservation, winding up or liquidation, a successor Warrant
Agent, qualified as aforesaid, shall be appointed by the Company by an instrument in writing, filed
with the successor Warrant Agent. Upon the appointment as aforesaid of a successor Warrant Agent
and acceptance by the successor Warrant Agent of such appointment, the Warrant Agent shall cease to
be Warrant Agent hereunder.



               (d) Any successor Warrant Agent appointed hereunder shall execute, acknowledge and deliver to
its predecessor and to the Company an instrument accepting such appointment hereunder, and
thereupon such successor Warrant Agent, without any further act, deed or conveyance, shall become
vested with all the authority, rights, powers, trusts, immunities, duties and obligations of such
predecessor with like effect as if originally named as Warrant Agent hereunder, and such
predecessor, upon payment of its charges and disbursements then unpaid, shall thereupon become
obligated to transfer, deliver and pay over, and such successor Warrant Agent shall be entitled to
receive, all monies, securities and other property on deposit with or held by such predecessor, as
Warrant Agent hereunder.



               (e) Any corporation into which the Warrant Agent hereunder may be merged or converted or any
corporation with which the Warrant Agent may be consolidated, or any corporation resulting from any
merger, conversion or consolidation to which the Warrant Agent shall be a party, or any corporation
to which the Warrant Agent shall sell or otherwise transfer all or substantially all the assets and
business of the Warrant Agent, provided that it shall be qualified as aforesaid, shall be the
successor Warrant Agent under this Agreement without the execution or filing of any paper or any
further act on the part of any of the parties hereto.



13









 





ARTICLE 6




MISCELLANEOUS




          6.1 Amendment. This Agreement may be amended by the parties hereto, without the consent of
the holder of any Warrant Certificate, for the purpose of curing any ambiguity, or of curing,
correcting or supplementing any defective provision contained herein, or making any other
provisions with respect to matters or questions arising under this Agreement as the Company and the
Warrant Agent may deem necessary or desirable; provided that such action shall not materially
adversely affect the interests of the holders of the Warrant Certificates.




          6.2 Notices and Demands to the Company and Warrant Agent. If the Warrant Agent shall receive
any notice or demand addressed to the Company by the holder of a Warrant Certificate pursuant to
the provisions of the Warrant Certificates, the Warrant Agent shall promptly forward such notice or
demand to the Company.




          6.3 Addresses. Any communication from the Company to the Warrant Agent with respect to this
Agreement shall be addressed to ___, Attention: ___and any communication from
the Warrant Agent to the Company with respect to this Agreement shall be addressed to Anadys
Pharmaceuticals, Inc., 3115 Merryfield Row, San Diego, California 92121, Attention: Legal Affairs
(or such other address as shall be specified in writing by the Warrant Agent or by the Company).




          6.4 Governing Law. This Agreement and each Warrant Certificate issued hereunder shall be
governed by and construed in accordance with the laws of the State of New York.




          6.5 Delivery of Prospectus. The Company shall furnish to the Warrant Agent sufficient copies
of a prospectus meeting the requirements of the Securities Act of 1933, as amended, relating to the
Warrant Securities deliverable upon exercise of the Warrants (the “Prospectus”), and the Warrant
Agent agrees that upon the exercise of any Warrant, the Warrant Agent will deliver to the holder of
the Warrant Certificate evidencing such Warrant, prior to or concurrently with the delivery of the
Warrant Securities issued upon such exercise, a Prospectus.



The Warrant Agent shall not, by reason of any such delivery, assume any responsibility for the
accuracy or adequacy of such Prospectus.




          6.6 Obtaining of Governmental Approvals. The Company will from time to time take all action
which may be necessary to obtain and keep effective any and all permits, consents and approvals of
governmental agencies and authorities and securities act filings under United States Federal and
state laws (including without limitation a registration statement in respect of the Warrants and
Warrant Securities under the Securities Act of 1933, as amended), which may be or become requisite
in connection with the issuance, sale, transfer, and delivery of the Warrant Securities issued upon
exercise of the Warrants, the issuance, sale, transfer and delivery of the Warrants or upon the
expiration of the period during which the Warrants are exercisable.




          6.7 Persons Having Rights Under Warrant Agreement. Nothing in this Agreement shall give to
any person other than the Company, the Warrant Agent and the holders of the Warrant Certificates
any right, remedy or claim under or by reason of this Agreement.




14









 








          6.8 Headings. The descriptive headings of the several Articles and Sections of this Agreement
are inserted for convenience only and shall not control or affect the meaning or construction of
any of the provisions hereof.




          6.9 Counterparts. This Agreement may be executed in any number of counterparts, each of which
as so executed shall be deemed to be an original, but such counterparts shall together constitute
but one and the same instrument.




          6.10 Inspection of Agreement. A copy of this Agreement shall be available at all reasonable
times at the principal corporate trust office of the Warrant Agent for inspection by the holder of
any Warrant Certificate. The Warrant Agent may require such holder to submit his Warrant
Certificate for inspection by it.




15









 








          In Witness Whereof, the parties hereto have caused this Agreement to be duly
executed, all as of the day and year first above written.




	 	 	 	 	 	 	 
	 	 	 	 	Anadys Pharmaceuticals, Inc.
	 
	 	 	 	 	 	 
	 

	 	 	 	By	 	 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 

	 	 	 	Its	 	 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	Attest:
	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	Warrant Agent
	 
	 	 	 	 	 	 
	 

	 	 	 	By	 	 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 

	 	 	 	Its	 	 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	Attest:
	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 	 	 





[Signature Page to Preferred Stock Warrant Agreement]




 









 








Exhibit A




FORM OF WARRANT CERTIFICATE

[Face of Warrant Certificate]




	 	 	 
	[Form if Warrants are attached to
Other Securities and are not
immediately detachable.

	 	Prior to                                         , this Warrant
Certificate cannot be transferred or
exchanged unless attached to a
[Title of Other Securities].]
	 
	 	 
	[Form of Legend if Warrants are not
immediately exercisable.

	 	Prior to                                         , Warrants
evidenced by this Warrant
Certificate cannot be exercised.]






EXERCISABLE ONLY IF COUNTERSIGNED BY THE WARRANT

AGENT AS PROVIDED HEREIN




VOID AFTER [                    ] P.M., [CITY] TIME, ON                                         ,




ANADYS PHARMACEUTICALS, INC.




WARRANT CERTIFICATE REPRESENTING

WARRANTS TO PURCHASE

[TITLE OF WARRANT SECURITIES]




													
	 	 	 	 	 	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 	 






			
	No.                                         
	 	                                         Warrants






          This certifies that                                          or registered assigns is the registered owner of the
above indicated number of Warrants, each Warrant entitling such owner [if Warrants are attached to
Other Securities and are not immediately detachable — , subject to the registered owner qualifying
as a “Holder” of this Warrant Certificate, as hereinafter defined),] to purchase, at any time
[after [                    ] p.m., [City] time, on                      and] on or before [                    ] p.m., [City] time, on
                                        ,                                                     shares of [Title of Warrant Securities] (the “Warrant Securities”), of Anadys
Pharmaceuticals, Inc. (the “Company”) on the following basis: during the period from                                         ,
through and including                                         , the exercise price per Warrant Security will be $                                        ,
subject to adjustment as provided in the Warrant Agreement (as hereinafter defined) (the “Warrant
Price”). The Holder may exercise the Warrants evidenced hereby by providing certain information
set forth on the back hereof and by paying in full, in lawful money of the United States of
America, [in cash or by certified check or official bank check in New York Clearing House funds]
[by bank wire transfer in immediately available funds], the Warrant Price for each Warrant Security
with respect to which this Warrant is exercised to the Warrant Agent (as hereinafter defined) and
by surrendering this Warrant Certificate, with the purchase form on the back hereof duly executed,
at the corporate trust office of [name of Warrant Agent], or its successor as warrant agent (the
“Warrant Agent”), which is, on the date hereof, at the address specified on the reverse hereof, and
upon compliance with and subject to the conditions set forth herein and in the Warrant Agreement
(as hereinafter defined).




A-1









 








          The term “Holder” as used herein shall mean [if Warrants are attached to Other Securities and
are not immediately detachable — prior to                                         ,                      (the “Detachable Date”), the
registered owner of the Company’s [title of Other Securities] to which this Warrant Certificate was
initially attached, and after such Detachable Date,] the person in whose name at the time this
Warrant Certificate shall be registered upon the books to be maintained by the Warrant Agent for
that purpose pursuant to Section 4 of the Warrant Agreement.




          The Warrants evidenced by this Warrant Certificate may be exercised to purchase a whole number
of Warrant Securities in registered form. Upon any exercise of fewer than all of the Warrants
evidenced by this Warrant Certificate, there shall be issued to the Holder hereof a new Warrant
Certificate evidencing Warrants for the number of Warrant Securities remaining unexercised.




          This Warrant Certificate is issued under and in accordance with the Warrant Agreement dated as
of                                         ,                      (the “Warrant Agreement”), between the Company and the Warrant Agent and is
subject to the terms and provisions contained in the Warrant Agreement, to all of which terms and
provisions the Holder of this Warrant Certificate consents by acceptance hereof. Copies of the
Warrant Agreement are on file at the above-mentioned office of the Warrant Agent.




          [If Warrants are attached to Other Securities and are not immediately detachable — Prior to
the Detachable Date, this Warrant Certificate may be exchanged or transferred only together with
the [Title of Other Securities] (the “Other Securities”) to which this Warrant Certificate was
initially attached, and only for the purpose of effecting or in conjunction with, an exchange or
transfer of such Other Security. Additionally, on or prior to the Detachable Date, each transfer
of such Other Security on the register of the Other Securities shall operate also to transfer this
Warrant Certificate. After such date, transfer of this] [If Warrants are attached to Other
Securities and are immediately detachable – Transfer of this] Warrant Certificate may be registered
when this Warrant Certificate is surrendered at the corporate trust office of the Warrant Agent by
the registered owner or such owner’s assigns, in the manner and subject to the limitations provided
in the Warrant Agreement.




          [If Other Securities with Warrants which are not immediately detachable — Except as provided
in the immediately preceding paragraph, after] [If Other Securities with Warrants which are
immediately detachable or Warrants alone — After] countersignature by the Warrant Agent and prior
to the expiration of this Warrant Certificate, this Warrant Certificate may be exchanged at the
corporate trust office of the Warrant Agent for Warrant Certificates representing Warrants for the
same aggregate number of Warrant Securities.




          This Warrant Certificate shall not entitle the Holder hereof to any of the rights of a holder
of the Warrant Securities, including, without limitation, the right to receive payments of
dividends or distributions, if any, on the Warrant Securities (except to the extent set forth in
the Warrant Agreement) or to exercise any voting rights.




          Reference is hereby made to the further provisions of this Warrant Certificate set forth on
the reverse hereof, which further provisions shall for all purposes have the same effect as if set
forth at this place.




A-2









 








          This Warrant Certificate shall not be valid or obligatory for any purpose until countersigned
by the Warrant Agent.




          In Witness Whereof, the Company has caused this Warrant to be executed in its name
and on its behalf by the facsimile signatures of its duly authorized officers.




	 	 	 	 	 	 	 	 	 
	Dated:                                        	 	 	 	Anadys Pharmaceuticals, Inc.
	 
	 	 	 	 	 	 	 	 
	 

	 	 	 	 	 	By	 	 
	 

	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	 

	 	 	 	 	 	Its	 	 
	 

	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Attest:	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Countersigned:	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 
	As Warrant Agent	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	By
	 	 	 	 	 	 	 	 
	 

	 	 	 	 	 	 	 	 
	 

	 	Authorized Signature	 	 	 	 	 	 






A-3









 






[REVERSE OF WARRANT CERTIFICATE]




(Instructions for Exercise of Warrant)




          To exercise any Warrants evidenced hereby for Warrant Securities (as hereinafter defined), the
Holder must pay, in lawful money of the United States of America, [in cash or by certified check or
official bank check in New York Clearing House funds] [by bank wire transfer in immediately
available funds], the Warrant Price in full for Warrants exercised, to [Warrant Agent] [address of
Warrant Agent], Attn:                                         , which payment must specify the name of the Holder and the
number of Warrants exercised by such Holder. In addition, the Holder must complete the information
required below and present this Warrant Certificate in person or by mail (certified or registered
mail is recommended) to the Warrant Agent at the appropriate address set forth above. This Warrant
Certificate, completed and duly executed, must be received by the Warrant Agent within five
business days of the payment.




(To be executed upon exercise of Warrants)




          The undersigned hereby irrevocably elects to exercise                                          Warrants, evidenced by this
Warrant Certificate, to purchase                                                     shares of the [Title of Warrant Securities] (the
“Warrant Securities”), of Anadys Pharmaceuticals, Inc. and represents that he has tendered payment
for such Warrant Securities, in lawful money of the United States of America, [in cash or by
certified check or official bank check in New York Clearing House funds] [by bank wire transfer in
immediately available funds], to the order of Anadys Pharmaceuticals, Inc., c/o [insert name and
address of Warrant Agent], in the amount of $                                         in accordance with the terms hereof. The
undersigned requests that said Warrant Securities be in fully registered form in the authorized
denominations, registered in such names and delivered all as specified in accordance with the
instructions set forth below.




          If the number of Warrants exercised is less than all of the Warrants evidenced hereby, the
undersigned requests that a new Warrant Certificate evidencing the Warrants for the number of
Warrant Securities remaining unexercised be issued and delivered to the undersigned unless
otherwise specified in the instructions below.




	 	 	 	 	 	 	 	 	 	 	 
	Dated

	 	 	 	 	 	Name	 	 	 	 
	 	 	 	 	 	 	 	 	 
	 

	 	 	 	 	 	 	 	 	 	(Please Print)
	 
	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	Address
	 

	 	 	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 





A-4









 






	 	 	 
	 

	 	 
	 

	 	(Insert Social Security or Other Identifying
Number of Holder)
	 
	 	 
	Signature Guaranteed
	 	 
	 

	 	 
	 

	 	Signature
	 
	 	 
	 

	 	(Signature must conform in all respects to
name of holder as specified on the face of
this Warrant Certificate and must bear a
signature guarantee by a bank, trust company
or member broker of the New York, Midwest or
Pacific Stock Exchange)





This Warrant may be exercised at the following addresses:




	 	 	 	 	 	 	 
	 

	 	By hand at	 	 	 	 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 
	 	 	 	 	 	 
	 

	 	By mail at	 	 	 	 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 

	 	 	 	 	 	 




[Instructions as to form and delivery of Warrant Securities and, if applicable, Warrant
Certificates evidencing Warrants for the number of Warrant Securities remaining unexercised –
complete as appropriate.]




A-5









 








ASSIGNMENT




[Form of assignment to be executed if

Warrant Holder desires to transfer Warrant)




     FOR VALUE RECEIVED,                                          hereby sells, assigns and transfers unto:



	 	 	 
	 
	 	 
	 
	 	 
	 	 	 
	 
	 	 
	 	 	 
	 

	 	 
	 

	 	 
	(Please print name and address
including zip code)

	 	Please insert Social Security or

other identifying number






 



the right represented by the within Warrant to purchase                      shares of [Title of Warrant
Securities] of Anadys Pharmaceuticals, Inc. to which the within Warrant relates and appoints
                                         attorney to transfer such right on the books of the Warrant Agent with full power of
substitution in the premises.




	 	 	 	 	 	 	 
	Dated

	 	 	 	 	 	 
	 

	 	 
	 	 	 	 
	 

	 	 	 	 	 	Signature
	 
	 	 	 	 	 	 
	 

	 	 	 	 	 	(Signature must conform in all respects to
name of holder as specified on the face of the
Warrant)
	 
	 	 	 	 	 	 
	Signature Guaranteed	 	 	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 





A-6