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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                 AMENDMENT NO. 2
                                       TO
                                  FORM 10-KSB/A

                 [X] ANNUAL REPORT UNDER SECTION 13 OR 15(D) OF
                       THE SECURITIES EXCHANGE ACT OF 1934

                   For the fiscal year ended December 31, 2004

                        COMMISSION FILE NUMBER 001-14257


                                  XTRANA, INC.
             (Exact Name of Registrant as Specified in its Charter)

              DELAWARE                                           58-1729436
   (State or Other Jurisdiction of                            (I.R.S. Employer
    Incorporation or Organization)                           Identification No.)

    P.O. BOX 668, SEDALIA, COLORADO                                80135
(Address of Principal Executive Offices)                         (Zip Code)

       Registrant's telephone number (including area code) (303) 466-4424

        Securities registered pursuant to section 12(b) of the Act: None

           Securities registered pursuant to section 12(g) of the Act:

                               TITLE OF EACH CLASS

                     Common Stock, par value $.01 per share

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Check  whether the issuer (1) filed all reports  required to be filed by Section
13 or 15(d) of the  Exchange  Act during the past 12 months (or for such shorter
period that the registrant was required to file such reports),  and (2) has been
subject to such filing requirements for the past 90 days. [X] Yes [ ] No

Check if there is no disclosure of delinquent  filers in response to Item 405 of
Regulation  S-B is not  contained  in  this  form,  and no  disclosure  will  be
contained,  to the  best of  registrant's  knowledge,  in  definitive  proxy  or
information statements incorporated by reference in Part III of this Form 10-KSB
or any amendment to this Form 10-KSB. [X]

State Issuer's revenues for its most recent fiscal year: $102,000.

The aggregate market value of Xtrana, Inc. Common Stock, $.01 par value, held by
non-affiliates,  computed  by  reference  to the  average of the closing bid and
asked prices as reported by OTCBB on March 1, 2005, was $2,479,990.

Number of shares of Common  Stock of Xtrana,  Inc.,  $.01 par value,  issued and
outstanding as of March 31, 2005: 16,533,269.

Transitional Small Business Disclosure Format (Check one): Yes [ ]; No [X]

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                                 AMENDMENT NO. 2
                  TO THE ANNUAL REPORT ON FORM 10-KSB FILED BY
                         XTRANA, INC. ON MARCH 31, 2005

         The  following  Item amends the Annual  Report on Form 10-KSB  filed by
Xtrana, Inc. (the "Company") on March 31, 2005, and amended by the Form 10-KSB/A
filed on May 2, 2005 (as amended, the "Form 10-KSB"),  as permitted by the rules
and regulations promulgated by the Securities and Exchange Commission.  The Form
10-KSB is hereby amended to insert the Item as set forth herein. All capitalized
terms used herein but not defined  shall have the  meanings  ascribed to them in
the Form 10-KSB.


ITEM 13. EXHIBITS

                EXHIBIT NO.         DESCRIPTION
                -----------         -----------

                  2.1               Assignment  Agreement dated January 24, 2004
                                    between the Company and Applera Corporation,
                                    though its Applied Biosystems Group (7)

                  2.1.1             First Amendment to the Assignment  Agreement
                                    dated March 31, 2004 between the Company and
                                    Applera  Corporation,  through  its  Applied
                                    Biosystems Group (9)

                  2.2               Agreement  and  Plan of  Merger  dated as of
                                    December 14, 2004, by and among the Company,
                                    AIC   Merger   Corp.   and  Alpha   Innotech
                                    Corporation (10)

                  3.1               Certificate of Incorporation (1)

                  3.2               By Laws (1)

                  4.1               Shareholder Rights Plan (3)

                  4.2               Second Rights  Agreement  Amendment  between
                                    the Company and American  Stock Transfer and
                                    Trust Company (11)

                  10.1              1993 Stock Incentive Plan (2) *

                  10.2              2000 Stock Incentive Plan (5) *

                  10.4              Lease Agreement - Broomfield, Colorado (6)

                  10.4.1            Lease Addendum Two for  Modification of Rent
                                    and  Early   Termination   of  Lease   dated
                                    November  11,  2003  between the Company and
                                    James M. Roswell d/b/a Burbank East Business
                                    Par.(7)

                  10.4.2            Lease  Addendum  Three for  Modification  of
                                    Rent and Early  Termination  of Lease  dated
                                    February  12,  2004  between the Company and
                                    James M. Roswell d/b/a Burbank East Business
                                    Park (7)

                  10.5              Secured  Promissory  Note Dated December 16,
                                    2004 made by Alpha  Innotech  Corporation in
                                    favor of the  Company  (Previously  filed on
                                    Form 10-KSB)

                  10.6              Pledge and General Security  Agreement dated
                                    December  16, 2004  between  Alpha  Innotech
                                    Corporation  and  the  Company   (Previously
                                    filed on Form 10-KSB)

                  10.7              Non-Exclusive Consulting Agreement effective
                                    as of March 20, 2004 between the Company and
                                    JHC Consulting Inc. *

                  14.1              Code of Ethical Conduct (8)

                  23.1              Consent of Independent  Auditors (Previously
                                    filed on Form 10-KSB)

                  24.1              Power of Attorney  (Previously filed on Form
                                    10-KSB)

                  31.1              Certificate of our Chief  Executive  Officer
                                    and Chief Financial Officer pursuant to Rule
                                    13a-14(a).

                  32.1              Certificate of our Chief  Executive  Officer
                                    and Chief Financial Officer pursuant to Rule
                                    13a-14(b). (Previously filed on Form 10-KSB)
         ----------
         *        Indicates a management contract or compensatory plan.

         (1)      Incorporated  by  reference to the  Registrant's  Registration
                  Statement on Form S-1 (File No. 33-20584).

         (2)      Incorporated by reference to the Registrant's Annual Report on
                  Form 10-KSB for the fiscal year ended December 31, 1994.

         (3)      Incorporated by reference to Registrant's  Form 8-A filed June
                  26, 1998.

         (4)      Incorporated by reference to the Registrant's Annual Report on
                  Form 10-KSB for the fiscal year ended December 31, 1999.


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         (5)      Incorporated  by reference to  Registrant's  Definitive  Proxy
                  Statement filed on June 23, 2000.

         (6)      Incorporated  by  reference  to  Registrant's  Form 8-K  filed
                  January 25, 2001.

         (7)      Incorporated by reference to Registrant's Form 10-KSB filed on
                  March 19, 2004.

         (8)      Incorporated  by reference to the  Registrant's  Form 10-KSB/A
                  filed on April 28, 2004.

         (9)      Incorporated by reference to the  Registrant's  Form 8-K filed
                  on May 24, 2004.

         (10)     Incorporated by reference to the  Registrant's  Form 8-K filed
                  on December 17, 2004.

         (11)     Incorporated by reference to the  Registrant's  Form 8-K filed
                  January 5, 2005.


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                                   SIGNATURES


         In  accordance  with  Section  13 or 15(d)  of the  Exchange  Act,  the
registrant  caused  this  report to be signed on its behalf by the  undersigned,
thereunto duly authorized.

                                         Xtrana, Inc.


Date:   July 7, 2005                     BY:  /S/ JAMES H. CHAMBERLAIN
                                         ---------------------------------------
                                         James H. Chamberlain
                                         Chief Executive Officer and Chief
                                         Financial Officer

         In accordance with Section 13 or 15(d) of the Exchange Act, this report
has been signed below by the following  persons on behalf of the  registrant and
in the capacities and on the dates indicated.


/S/ MICHAEL D. BICK             Chairman of the Board               July 7, 2005
---------------------------     of Directors
Michael D. Bick, Ph.D.


/S/ JAMES H. CHAMBERLAIN        Chief Executive Officer, Chief      July 7, 2005
---------------------------     Financial Officer and Director
James H. Chamberlain


         *                      Director                            July 7, 2005
---------------------------
Douglas L. Ayer


         *                      Director                            July 7, 2005
---------------------------
N. Price Paschall


         *                      Director                            July 7, 2005
---------------------------
John C. Gerdes, Ph.D.


         *                      Director                            July 7, 2005
---------------------------
James Mahony, Ph.D.


         * By:   /S/ JAMES H. CHAMBERLAIN
                 ---------------------------
                     James H. Chamberlain
                     As Attorney-In-Fact


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