Acetochlor (PC Code 12160 1) Dietary Exposure and Risk Assessment DP #: 408112

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460



### Office of Chemical Safety and Pollution Prevention



### MEMORANDUM



### January 16

, 2013



### SUBJECT: Acetochlor- Revised Acute and Chronic Dietary and Drinking Water Exposure

and Risk Assessments.

PC Code: 121601 DP Barcode: 4081 12

Decision No.: 461987 Registration No.: 524-591

Petition No.: PP#2F7996 Regulatory Action: Section 3

Risk Assessment Type: Dietary Case No.: 7230

TXR No.: NA CAS No: 34256-82-1

MRID No.: NA 40 CFR: 180.470
7 

# L

Reviewer: Thurston G. Morton, Chemist

# ~**~ ~** 

Through:

TO: 

### Risk Assessment Branch IV/Hea l tli Effects Division (RABIV/H ED; 7509P)

And

Susan V. Hummel

, Senior Chemist

RABIV/HED (7509 P)

Hope Johnson

Herbicide Branch/RD (7505P)

This document provides an acute and chronic dietary and drinking water risk analyses of

exposures re s ulting from use of acetochlor on food crops for weed control. This assessment
supports a Section 3 request to remove the exception for rice as a rotational crop from the cereal grain inadvertent tolerances. No updated cumulative assessment is needed.

Pag e 1 of 19Acetochlor (PC Code 12160 1) D ie tary Exposure and Risk Assessment DP #: 408112



### Executive Summary



### Unrefined acute and partially refined chronic dietary risk assessments were conducted for

acetochlor. The analyses were performed to support Section 3 amendment and associated petition to remove th e exception for rice as a rotat ional crop from the cereal grain inadvertent

tolerances.

Acute Dietary Exposure Analysis Results and Characterization

A screeni n g l eve l acute dietary exposure analysis was p erforme d for the general population and

all population s ubgroups. The acute dietary analysis assumed tolerance level residues and 100%

crop treated for all commodities. Experimentally derived processing factors were used for cereal grain commodities. Default processing factors were used for all other commodities. The acute analysis incorporated the 1 in 1 0 year peak surface drinking water estimate from application of

acetochlor to sorghum. The re sul ting 95th percentile acute exposure estimate for infants < 1 year
old (the most highly exposed s ubgroup) is not of concern to HED (<1% acute population adjusted dose (aPAD)). The exposure estimate for the U.S

. popu la tion was< 1% ofthe aPAD.

Chronic Die tary E xposure Analysis Results and Charac ter ization

A partially refined chronic dietary exposure analysis was performed for the general U.S. population and various population subgroups. Anticipated residues from field trial data and 100%



### crop treated assumptions were made for all commodities. Ex p erimen tally derived processing

factors were used for cereal grain commodities. Default processing factors we re used for all

other commodities. The chronic analy s is incorporated the 1 in 10 year average surface drinking

water es t imate from application of acetochlor to sorghum. Chronic dietary risk estimates are not
of concern for general population or other population subgroups. The subgroup with the highest

r isk estimate was infants< 1 year old with an exposure estimate of6.2% of the cPAD. The general U.S. population estima ted exposure was 2.1% of the cP AD.

Cancer Dietary E xposure Analysis Results and Charac terization

H E D has d e termined that linear quantification of carcinogenic poten t ial is not required for the

mouse tumors

. There are acceptable mode of action data for the rat tumors (nasal olfactory epithelial tumor s and thyroid follicular cell tu mor s) which are adequate to support a non

- linear

MOE approach for assessment of cancer risk

. The rat nasal tumors, with a POD of 10 mg!kg/day

are the mo st sensitive effec t for cancer risk. Quantification of cancer risk is not required since

the chronic RID of 0.02 mg!kg/day will be protective of both non-cancer and cancer effects, including rat nasal tumors, thyroid tumors, and mouse tumors. As noted above, chronic d i etary
risks do not exceed HED's level of concern.

Page 2 of 19Acetochlor (PC C ode 121601 ) Dietary Exposure and Risk Assessment DP #: 40 8112



### Page 3 of 19 Cumulative Dietary Exposure

Acetochlor is included in a Cumulative Assessment Group (CAG) of Chloroacetanilide pesticides. For purposes of a cumulative risk assessment, it was determined that the common mechanism of toxicity group consists of alachlor, acetochlor and butachlor. Based on the most

recent c hloroacetanilide CAG cumulative risk assessment, c umulative risk is not of concern. A revised quantitative cumulative assessment was not conducted because the proposed amended

use would not affect the cumulative risk results. Not only is acetochlor is a very minor

contributor to chloroacetanilide cumulative risk when compared to alachlor but removing the exception for rotation to rice will only have a minor impact on acetochlor exposure.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects).

This dose is referre d to as the population adjusted dose (PAD). The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non

- cancer chronic exposures, HED is concerned when estimated dietary r isk exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk exceeds one

in one million. References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Informa tion on Assessing Exposure from Pesticides, A User’s Guide,” 21

- JUN

- 2000, web link: http://www.epa.gov/fedrgstr/EPA

PEST/2000/July/Day

- 12/6061.pdf ; or see SOP 99.6 (20

- AUG

- 1999).

Acetachlor had a previous dietary risk assessment conducted (B. Daiss, D360868, 7/1/09).

II. Residue Information

Residues of Concern

The residues of concern in plants includes parent and any metabolites containing the ethyl methyl aniline (EMA ) or hydroxyethyl methyl aniline (HEMA) moiety, expressed in acetochlor equivalents. The residues of concern in rotational crops are acetochlor, its EMA and HEMA type metabolites as well as its hydroxymethyl ethyl aniline (HMEA) type metabolites. HED has concluded that the tolerance expression for rotational crops should include only acetochlor and its EMA and HEMA type metabolites; however the acetochlor HMEA type metabolites should

be included in the risk assessment (M. Flood, MARC Memorandum, 9/30/93). Table 1 provides a summary of the MARC decisions regarding residues of concern for acetochlor

.Acetochlor (PC C ode 121601 ) Dietary Exposure and Risk Assessment DP #: 40 8112



### Page 4 of 19 Table 1: Summ ary of MARC Decisions for Acetochlor

Matrix Residues of Concern

For Risk Assessment For Tolerance Expression

Plants Parent and meta bolites containing the EMA

or HEMA or HMEA moiety Parent and metabolites containing the EMA or HEMA moiety Rotational Crops Parent and metabolites containing the EMA

or HEMA or HMEA moiety Parent and metabolites containing the EMA or HEMA moiety

Drinkin g Water Parent Only NA



### Established/Recommended Tolerances

Tolerances for acetochlor are currently established under 40 CFR §180.470(a) and (d) Tolerances for acetochlor are expressed in terms of acetochlor and its metabolites containing the EMA (2

- ethy l

- 6

- methylaniline) and HEMA (2

- (1

- hydroxyethyl)

- 6

- methylaniline) moieties. Tolerances for field corn, pop corn, sweet corn, and sorghum commodities range from 0.05 ppm to 3.0 ppm. Tolerances for rotational crops, nongrass animal feeds, sugar beet root a nd tops, cereal grain commodities, peas and beans, potato, soybean commodities, sunflower seed, and wheat commodities range from 0.1 ppm to 1.0 ppm. No tolerances have been established for

livestock commodities. Recommended tolerances for the proposed ne w u se are as follows (by removal of rice as an exception from the cereal grain tolerance)

.

Rice, grain

................................ ................................ ............ 0.05 ppm

The submitted field trial data for all rotational commodities did not sample for the HMEA

metabolite . H owever, no quantifiable residues of acetochlor or HEMA were found in any of the cereal grain, sugar beet, or potato commodities. Based on the available rotational crop metabolism studies conducted on lettuce, radish, and wheat, the EMA producing metabolites were present at the highest conce ntrations, followed by the HEMA

- and HMEA

- type metabolites. Therefore, if acetochlor or HEMA were non

- quantifiable in any samples, it is reasonable to assume that HMEA would be less than LOQ and use of established tolerances for rotational crops is appropr iate

.

Residues Used in the Acute Analysis

For the acute dietary analysis, tolerance level residues were used for all crops. 100% crop treated was assumed for all commodities in the assessment. Experimentally derived processing factors were applied to pro cessed cereal grain commodities. DEEM Default processing factors were

used for all other commodities.Acetochlor (PC C ode 121601 ) Dietary Exposure and Risk Assessment DP #: 40 8112



### Page 5 of 19 Residues U sed in the Chronic Analysis

For the chronic dietary analysis, tolerance level residues were used for rice, soybean and cotton

commod ities. A verage field trial residue values were used for all other crops. 100% crop treated was assumed for all commodities in the assessment. Experimentally derived processing factors were applied to processed cereal grain commodities. DEEM Default pro cessing factors were

used for all other commodities.

Residues used in the acute and chronic dietary analyses are provided in Table 2

.

Table 2 . Data and Residue Estimates Used in Acetochlor Dietary and Drinking Water Analyses

RAC Blending

Status 1 Data

S ource LOD %CT PF Residues (ppm)
Acute (Tol) Chronic (AR)

Beet, Sugar B Tolerance &

Field Trial Data

45322103 24 samples 0.04 100 None 0.05 0.02

Cereal grain, except corn, sorghum and rice, group 15 (barley, buckwheat, millet, oat, rye, triticale, wheat) B Tolerance &

Field Trial Data

45322108

17 samples 0.035 100 Flour 0.5X

Groats 0.4X 0.05 0.02

Corn, field and pop, grain B Tolerance &

Field Trial Data

41592014

42713114 ; 15

40365601 2 samples 0.03 100 Flour, meal,

starch and

oil 0.6X 0.05 0.02

Corn, sweet, K

- CWHR NB/PB Tolerance &

Field Trial Data

44107105

32 samples 0.04 100 None 0.05 0.02

Pea and bean, dried shelled, except soybean, subgroup 6C B Tolerance &

Field Trial Data

45322104

45322105

28 samples 0.04 100 None 0.05 0.02

Potato NB/PB/

B Tolerance &

Field Trial Data

45322107

10 samples 0.04 100 Dried 6.5X 0.05 0.02

Soybean, seed B Tolerance N/A 100 Flour 0.75X

Oil 0.2X 1.0 Tol 1.0

Sorghum B Tolerance N/A 100 None 0.05 Tol 0.05

Sunflower seed PB/B Tolerance &

Field Trial Data

45322106

16 samples 0.04 100 None 0.05 0.02

Rice B Tolerance 0.05 100 0.05 0.05

Water N/A Mo deling Data N/A N/A N/A 0.0 749 0.00484

1 Classification of blended (B), partially blended (PB), not blended (NB).Acetochlor (PC C ode 121601 ) Dietary Exposure and Risk Assessment DP #: 40 8112



### Page 6 of 19 III. Water Data

A new drinking water assessment did n ot need to be conducted for this amendment since no new primary crops were added , so the previous assessment was used. Drinking water residues were incorporated directly into the acute and chronic dietary analyses ( “water, direct, all sources” and “water, indirect, all sources”) and were provided by the Environmental Fate and Effects Division (EFED ) ( D 35 9995

, M

. Barrett

, 6/ 24 /2009 ). Acetochlor parent residue exposure is generally higher and more widespread through surface water sources than ground water, therefore, EFED generated the surface water concentrations using the PRZM (Pesticide Root Zone Model; version 3.12 Beta compiled May 24, 2001) and EXAMS (Exposure Analysis Modeling System; version 2.98.04, compiled November 12, 2002). Th e drinking water assessment provides modeling

based Tier 2 drinking water exposure estimates for the proposed uses of acetochlor on soybeans and cotton along with the existing uses on corn (including sweet corn, popcorn, field corn, and corn for silage ) and sorghum

. E stimates for the use of acetochlor on sorghum were used in the screening level dietary assessment because this use produces the EDWCs of the registered uses

. Surface water EDWCs for acetochlor are provided in Table 3

. Using Tier 2 estima tion methods, parent acetochlor concentrations in drinking water are estimated to be up to 74.9 ug/L (ppb) for instantaneous exposure and 4.84 ppb for annual exposure.

Table 3

. Modeled EDWCs for Use of Acetochlor on Sorghum (ug/L) Underlined values Reco mmended by

EFED for Dietary Exposure Assessment.

Exposure Scenario Peak Day 365 Day Avg Lifetime (30 yr Avg)

KS Sorghum (2.5 lb ai/ A ) 49.9 to 74.9 4.14 to 4.84 0.29 to 1.12

Corn

– scenarios from IL, MS, NC, OH, and PA (3 lb ai/A rate) 14.3 to 44.5 2 .08 to 6.56 0.72 to 2.96

Cotton

– scenarios from CA, MS,

and NC 3.56 to 20.0 0.55 to 2.16 0.29 to 1.12

MS Soybean 28.0 4.68 2.18



### IV. DEEM

- FCIDTM Program and Consumption Information

Acet o chlor acute and chronic dietary exposure assessments were conduct ed using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database DEEM

FCIDTM, Version 3.16, which incorporates consumption data from USDA’s National Health and Nutrition Examination Survey, What We Eat in America, (NHANES/WWEI A). This dietary survey was conducted from 2003 to 2008. The data are based on the reported consumption of more than 20,000 individuals over two non

- consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked to EPA

- defined food commoditie s (e.g. apples, peeled fruit

- cooked; fresh or N/S; baked; or wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averag ed for the entire U.S. population and within population subgroups,Acetochlor (PC C ode 121601 ) Dietary Exposure and Risk Assessment DP #: 40 8112



### Page 7 of 19 but for acute exposure assessment are retained as individual consumption events. Based on analysis of the 2003

- 2008 WWEIA consumption data, which took into account dietary patterns

and sur vey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, a nd adults 50

- 99 years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food

form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for th at food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average

es timated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup.

For acute exposure assessments, individual one

- day food consumption data are used on an

individual

- b y

- individual basis. The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings wi th residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per

- capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for all tiers of analysis. However, for tiers 1 and 2, any significant

differences in user v s. per capita exposure and risk are specifically identified and noted in the risk

assessment.

V. Toxicological Information

HED evaluated the toxicology data base for acetochlor and selected the following doses and endpoints for acute and chronic dietary and drinking water risk assessments.Acetochlor (PC C ode 121601 ) Dietary Exposure and Risk Assessment DP #: 40 8112



### Page 8 of 19 Table 4 . Summary of Toxicological Doses and Endpoints for Acetochlor for Use in Dietary and Non

- Occupational Human

Health Risk Assessments

Exposure/Scenario Point of Departure Uncertainty/FQPA

Safety Fa ctors RfD, PAD, LOC

for Risk

Assessment Study and Toxicological Effects

Acute Dietary (All populations) NOAEL =

150 mg/kg/day UF A = 10x

UF H =10x FQPA SF= 1x Acute RfD = 1.5

mg/kg/day

aPAD = 1.5 mg/kg/day Acute oral neurotoxicity screening in rats

LOAEL = 500mg/kg/day based on decreased motor activity in females.

Chronic Dietary (All Populations) NOAEL = 2.0 mg/kg/day UF A = 10x

UF H =10x FQPA SF= 1x Chronic RfD =

0. 02 mg/kg/day

cPAD = 0. 02 mg/kg/day Chronic oral toxicity in beagle dogs

LOAEL = 10 mg/kg/day based on increased salivation and histopathology in the testes, kidney and liver.

Cancer ( all routes ) Classification: “ Suggestive Evidence of Carcinogenic Potential". Quantification of cancer risk is not

required since the cRfD of 0.02 mg/kg/day will be protective of both non

- cancer and cancer effects

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose

- response data and used to mark the beginning of extrapolation to determine risk associated with lower enviro nmentally relevant human exposures. NOAEL = no observed adverse effect level.

NOAEL = no observed adverse effect level.

LOAEL = lowest observed adverse effect level. UF = uncertainty factor.

UF A = extrapolation from animal to human (interspecies).

UF H = potential variation in sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic).

RfD = reference dose.



### VI. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds

100% of the PAD. The DEEM

- FCIDTM analyses estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Tables 5 and 6 are for the general U.S. Population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth

13

- 19, females 13

- 49, adults 20

- 49, and adults 50

- 99 years.

Results of Acute Dietary Exposure Analysis

The results of the acute dietary exposure anal ysis at the 95 th 

### percentile of exposure are reported in

Table 5

.Acetochlor (PC C ode 121601 ) Dietary Exposure and Risk Assessment DP #: 40 8112



### Page 9 of 19 Table 5 : Summary of Acute Dietary Exposure and Risk for Acetochlor

Population Subgroup aPAD (mg/kg/day) Acute ( 95 th Percentile) Exposure (mg/kg/day) % a PAD General U.S. Populat ion

0.15 0.004 913 <1 All Infants (< 1 year old) 0.01 4093 <1
Children 1

- 2 years old 0.00 80 84 <1
Children 3

- 5 years old 0.006749 <1
Children 6

- 12 years old 0.004796 <1
Youth 13

- 19 years old 0.003943 <1
Adults 20

- 49 years old 0.004696 <1
Adults 5 0

- 99 years old 0.004138 <1
Females 13

- 49 years old 0.00 4 7 39 <1



### Results of Chronic Dietary Exposure Analysis

The results of the chronic dietary exposure analysis are reported in T able 6

.

Table 6 : Summary of Chronic Dietary Exposure and Risk for A cetochlor

Population Subgroup cPAD (mg/kg/day) Chronic Exposure (mg/kg/day) % cPAD General U.S. Population

0. 0 0 2 0.000 419 2

. 1 All Infants (< 1 year old) 0.00 0912 4

. 6

Children 1

- 2 years old 0.001 244 6

. 2

Children 3

- 5 years old 0.00 0915 4

. 6

Childr en 6

- 12 years old 0.000537 2

. 7

Youth 13

- 19 years old 0.000315 1

. 6

Adults 20

- 49 years old 0.000359 1

. 8

Adults 50

- 99 years old 0.000 331 1

. 7

Females 13

- 49 years old 0.000 342 1

. 7



### VI. Characterization of Inputs/Outputs

The acute dietary analysis is an un refined screening level analysis

. I n addition, the 100% crop treated estimate used for all crops in the assessment will considerably overestimate the actual percent crop treated.

The chronic dietary analysis is somewhat refined

. Average field tri al residues used in the analysis are expected to exceed the residues actually consumed. In addition, the 100% crop treated estimate used for all crops in the assessment will considerably overestimate the actual percent crop treated.

VII. Conclusions

A cute and chronic dietary exposure analys e s w ere performed for the general U.S. population and various population subgroups. The risk estimates for the general U.S. population and all population subgroups are below HED’s level of concern. HED is confident that acute and chronic dietary exposures to acetochlor are not underestimated.Acetochlor (PC C ode 121601 ) Dietary Exposure and Risk Assessment DP #: 40 8112



### Page 10 of 19 VIII. Cumulative Risk

As part of the provisions of the Food Quality Protection Act (FQPA, 1996), EPA must consider the cumulative effects on human health that may result fro m exposure to different chemicals that cause toxic effects by the same mode of action. The chloroacetanilides have been evaluated by the Agency and the FIFRA Scientific Advisory Panel (SAP) as a related group of chemicals for this purpose. Acetoc h lor is i ncluded in a Cumulative Assessment Group (CAG) of

Chloroacetanilide pesticides. Structurally related chloroacetanilides include acetochlor, alachlor, butachlor, propachlor and metolachlor. For purposes of a cumulative risk assessment, it was

determined t hat the common mechanism of toxicity group consists of alachlor, acetochlor and

butachlor. B utachlor is excluded from the group for risk assessment purposes at present there are no registered uses or tolerances for this chemical in the US. The group was selected based on common endpoints of (1) nasal turbinate tumors in rats, and a known mechanism of toxicity for development of these tumors and (2) induction of hepatic UDP

- Glucuronosyl Transferase ( UDPGT ) , which results in increased incidence of thyroid f ollicular cell tumors secondary to disruption of pituitary

- thyroid homeostasis

. Thyroid effects were not included in the final cumulative assessment of the chloroacetanilide herbicides because they were determined to occur at excessively toxic dose levels , and therefore were not considered relevant to human risk assessment. Nasal tumors represent the most sensitive endpoint for both compounds.

An updated cumulative risk assessment of the Chloroacetanilide (CAG) pesticides

acetoc h lor and al a chlor conduct ed in April, 2007 provide s an assessment of existing and new

uses of those chemicals to date (Y. Donovan, D336214 , 4/30/07) . Based on the most recent

c hloroacetanilide CAG cumulative risk assessment, c umulative risk is not of concern. A revised quantitat ive cumulative assessment was not conducted because the proposed amended use would

not affect the cumulative risk results. Not only is acetochlor is a very minor contributor to

chloroacetanilide cumulative risk when compared to alachlor but removing the e xception for rotation to rice will only have a minor impact on acetochlor exposure.Acetochlor (PC C ode 121601 ) Dietary Exposure and Risk Assessment DP #: 40 8112



### Page 11 of 19 VIII. List of Attachments

1. Acute DEEM

- FCID Residue Input File.

2. Results of Acute DEEM

- FCID Dietary Exposure Analysis.

3. Chronic DEEM

- FCID Residue Input File.

4 . Results of Chronic DEEM

- FCID Dietary Exposure Analysis.Acetochlor (PC C ode 121601 ) Dietary Exposure and Risk Assessment DP #: 40 8112



### Page 12 of 19 Attachment 1 Acute DEEM

- FCID Residue Input File

Filename: C: \ Documents and Settings \ tmorton \ My Documents \ MyFiles \ DEEM Files \ 121601

Acetochlor \ Acetochlor Adding Rice as a Rot Crop \ 121601 ACUTE.R08

Chemical: Acetochlor RfD(Chronic): .02 mg/kg bw/day NOEL(Chronic): 2 mg/kg bw/day RfD(Acute): 1.5 mg/kg bw/day NOEL(Acute): 150 mg/kg bw/day Date created/last modified: 01

- 16

- 2013/12:06:04 Program ver. 3.16, 03

- 08

- d

Comment: Run with new commodit ies at tolerance & 100% CT

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101052000 1A Beet, sugar 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 0101052001 1A Beet, s ugar

- babyfood 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 0101053000 1A Beet, sugar, molasses 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT

010329600 0 1C Potato, chips 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 0103297000 1C Potato, dry (granules/ flakes) 0.050000 6.500 1.000 new ro

Full comment: new rot crop tol; 100 % CT; PF used 0103297001 1C Potato, dry (granules/ flakes)

- b 0.050000 6.500 1.000 new ro

Full comment: new rot crop tol; 100% CT; PF used 0103298000 1C Potato, flour 0.050000 1.000 1.000 new ro

Ful l comment: new rot crop tol; 100% CT 0103298001 1C Potato, flour

- babyfood 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 0103299000 1C Potato, tuber, w/peel 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 0103299001 1C Potato, tuber, w/peel

- babyfood 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 0103300000 1C Potato, tuber, w/o peel 0.050000 1.000 1 .000 new ro

Full comment: new rot crop tol; 100% CT 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 0600347000 6 Soybean, seed 1.000 000 1.000 1.000 new to

Full comment: new tolerance; 100% CT 0600349000 6 Soybean, soy milk 1.000000 1.000 1.000 new to

Full comment: new tolerance; 100% CT 0600349001 6 Soybean, soy milk

- babyfood or in 1.000000 1.000 1.000 new to

Full comment: new tolerance; 100% CT 0600350000 6 Soybean, oil 1.000000 0.200 1.000 new to

Full comment: new tolerance; 100% CT 0600350001 6 Soybean, oil

- babyfood 1.000000 0.200 1.000 new to

Full comment: new tolerance; 100% CT 0603030000 6C Bean, black, seed 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 0603032000 6C Bean, broad, seed 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 0603034000 6C Bean, cowpea, seed 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT

0603035000 6C Bean, great northern, seed 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 0603036000 6C Bean, kidney, seed 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT

0 603038000 6C Bean, lima, seed 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 0603039000 6C Bean, mung, seed 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 0603040000 6C Bean, navy, seed 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 0603041000 6C Bean, pink, seed 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 0603042000 6C Bean, pinto, seed 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 0603098000 6C Chickpea, seed 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 0603098001 6C Chickpea, seed

- babyfood 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CTAcetochlor (PC C ode 121601 ) Dietary Exposure and Risk Assessment DP #: 40 8112



### Page 13 of 19 0603099000 6C Chickpea, flour 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 0603182000 6C Guar, seed 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 0603182001 6C Guar, seed

- babyfood 0.050000 1.00 0 1.000 new ro

Full comment: new rot crop tol; 100% CT 0603203000 6C Lentil, seed 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 0603256000 6C Pea, dry 0 .050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 0603256001 6C Pea, dry

- babyfood 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 0603258000 6C Pea, pigeon, seed 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 0603348000 6C Soybean, flour 1.000000 0.750 1.000 new to

Full comment: new tolerance; 100% CT 0603348001 6C Soybean, fl our

- babyfood 1.000000 0.750 1.000 new to

Full comment: new tolerance; 100% CT 1500025000 15 Barley, pearled barley 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100%CT

1500025001 15 B arley, pearled barley

- babyfood 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100%CT 1500026000 15 Barley, flour 0.050000 0.500 1.000 new ro

Full comment: new rot crop tol; 100% CT; PF used 1500026001 15 Barley, flour

- babyfood 0.050000 0.500 1.000 new ro

Full comment: new rot crop tol; 100% CT; PF used 1500027000 15 Barley, bran 0.050000 1.000 1.000 new ro

Full comment : new rot crop tol; 100% CT

1500065000 15 Buckwheat 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 1500066000 15 Buckwheat, flour 0.050000 0.500 1.000 new ro

Full comment: new rot crop tol; 100% CT; PF used 1500120000 15 Corn, field, flour 0.050000 0.600 1.000 existi

Full comment: existing use; 100% CT 1500120001 15 Corn, field, flour

- babyfood 0.050000 0.600 1.000 existi

Full comment: existing use; 100% CT 1500121000 15 Corn, field, meal 0.050000 0.600 1.000 existi

Full comment: existing use; 100% CT 1500121001 15 Corn, field, meal

- babyfood 0.050000 0.600 1.000 existi

Full comment: existing use; 100% CT 1500122000 15 Corn, field, bran 0.050000 1.000 1.000 existi

Full comment: existing use; 100% CT 1500123000 15 Corn, field, starch 0.050000 0.600 1.000 existi

Full comment: existing use; 100% CT 1500123001 15 Corn, field, starch

- babyfood 0.050000 0.600 1.000 existi

Full comment: existing use; 100% CT 1500124000 15 Corn, field, syrup 0.050 000 1.500 1.000 existi

Full comment: existing use; 100% CT 1500124001 15 Corn, field, syrup

- babyfood 0.050000 1.500 1.000 existi

Full comment: existing use; 100% CT 1500125000 15 Corn, field, oil 0.050000 0.600 1.000 existi

Full comment: existing use; 100% CT 1500125001 15 Corn, field, oil

- babyfood 0.050000 0.600 1.000 existi

Full comment: existing use; 100% CT 1500126000 15 Corn, pop 0.050000 1.000 1.000 new to

Full comment: new tolerance; 100% CT 1500127000 15 Corn, sweet 0.050000 1.000 1.000 new to

Full comment: new tolerance; 100% CT 1500127001 15 Corn, sweet

- babyfood 0.050000 1.000 1.000 new to

Full comment: new tolerance; 100% CT 1500226000 15 Millet, grain 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 1500231000 15 Oat, bran 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 1500232000 15 Oat, flour 0.050000 0.500 1.000 new ro

Full comment: new rot crop tol; 100% CT; PF used

15 00232001 15 Oat, flour

- babyfood 0.050000 0.500 1.000 new ro

Full comment: new rot crop tol; 100% CT; PF used 1500233000 15 Oat, groats/rolled oats 0.050000 0.400 1.000 new ro

Full comment: new r ot crop tol; 100% CT; PF used 1500233001 15 Oat, groats/rolled oats

- babyfood 0.050000 0.400 1.000 new roAcetochlor (PC C ode 121601 ) Dietary Exposure and Risk Assessment DP #: 40 8112



### Page 14 of 19 Full comment: new rot crop tol; 100% CT; PF used 1500323000 15 Rice, white 0.050000 1.000 1.000

15003 23001 15 Rice, white

- babyfood 0.050000 1.000 1.000 1500324000 15 Rice, brown 0.050000 1.000 1.000 1500324001 15 Rice, brown

- babyfood 0.050000 1.000 1.000 1500325000 15 Rice, flour 0.050000 1.000 1.000 1500325001 15 Rice, flour

- babyfood 0.050000 1.000 1.000 1500326000 15 Rice, bran 0.050000 1.000 1.000 1500326001 15 Rice, bran

- babyfood 0.05 0000 1.000 1.000 1500328000 15 Rye, grain 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100% CT 1500329000 15 Rye, flour 0.050000 0.500 1.000 new ro

Full comment: new rot crop tol; 100% CT; PF used 1500344000 15 Sorghum, grain 0.050000 1.000 1.000 new to

Full comment: new tolerance; 100% CT 1500345000 15 Sorghum, syrup 0.050000 1.000 1.000 new to

Full comment: new tolerance; 100% CT 1500381000 15 Triticale, flour 0.050000 0.500 1.000 new ro

Full comment: new rot crop tol; 100%CT; PF Used 1500381001 15 Triticale, flour

- babyfood 0.050000 0.500 1.000 new ro

Full comment: new rot crop tol; 100%CT; PF Used 1500401000 15 Wheat, grain 0.050000 1.000 1.000 establ

Full comment: established

- rot crop; 100 % CT 1500401001 15 Wheat, grain

- ba byfood 0.050000 1.000 1.000 establ

Full comment: established

- rot crop; 100 % CT 1500402000 15 Wheat, flour 0.050000 0.500 1.000 establ

Full comment: established

- rot crop; 100 % CT; PF Used 1500402001 15 Wheat, flour

- babyfood 0.050000 0.500 1.000 establ

Full comment: established

- rot crop; 100 % CT; PF Used 1500403000 15 Wheat, germ 0.050000 1.000 1.000 establ

Full comment: established

- rot crop; 100 % CT 1500404000 15 Wheat, bran 0.050000 1.000 1.000 establ

Full comment: established

- rot crop; 100 % CT

1500405000 15 Wild rice 0.050000 1.000 1. 000 2002364000 20B Sunflower, seed 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100%CT 2002365000 20B Sunflower, oil 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100%CT 2002365001 20B Sunflower, oil

- babyfood 0.050000 1.000 1.000 new ro

Full comment: new rot crop tol; 100%CT 2003128000 20C Cottonseed, oil 0.600000 1.000 1.000 new to

Full comm ent: new tolerance; 100% CT 2003128001 20C Cottonseed, oil

- babyfood 0.600000 1.000 1.000 new to

Full comment: new tolerance; 100% CT 8601000000 86A Water, direct, all sources 0.074900 1.000 1.000 Based

F ull comment: Based on corn monitoring data 8602000000 86B Water, indirect, all sources 0.074900 1.000 1.000 Based

Full comment: Based on corn monitoring dataAcetochlor (PC C ode 121601 ) Dietary Exposure and Risk Assessment DP #: 40 8112



### Page 15 of 19 Attachment 2 Results of Acute DEEM

- FCID Dietary Exposure Analysis

U.S . EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for ACETOCHLOR NHANES 2003

- 2008 2

- Day Residue file: 121601 ACUTE.R08 Adjustment factor #2 NOT used. Analysis Date: 01

- 1 6

- 2013/12:13:13 Residue file dated: 01

- 16

- 2013/12:06:04 NOEL (Acute) = 150.000000 mg/kg body

- wt/day RAC/FF intake summed over 24 hours

Run Comment: "Run with new commodities at tolerance & 100% CT"

======================================================= ========================

Summary calculations

-- per capita:

--- 95th Percentile

---- --- 99th Percentile

---- --- 99.9th Percentile

---- Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- Total US Population:

0.004913 0.33 30528 0.008861 0.59 16927 0.020271 1.35 7399

All Infants:

0.014093 0.94 10643 0.020274 1.35 7398 0.041625 2.78 360 3

Children 1

- 2:

0.008084 0.54 18554 0.025015 1.67 5996 0.088443 5.90 1696

Children 3

- 5:

0.006749 0.45 22224 0.015355 1.02 9768 0.044854 2.99 3344

Children 6

- 12:

0.004796 0.32 31276 0.008888 0.59 16876 0.028437 1.90 5274

Youth 13

- 19:

0.003943 0.26 38041 0.006340 0.42 23659 0.012954 0.86 11579

Adults 20

- 49:

0.004696 0.31 31939 0.007393 0.49 20289 0.012381 0.83 12115

Adults 50

- 99:

0.004138 0.28 36250 0.006680 0.45 22455 0.014170 0.94 10585

Female 13

- 49:

0.004739 0.32 31653 0.007265 0.48 20645 0.012649 0.84 11858Acetochlor (PC C ode 121601 ) Dietary Exposure and Risk Assessment DP #: 40 8112



### Page 16 of 19 Attachment 3 Chronic DEEM

- FCID Resi due Input File.

Filename: C: \ Documents and Settings \ tmorton \ My Documents \ MyFiles \ DEEM Files \ 121601

Acetochlor \ Acetochlor Adding Rice as a Rot Crop \ 121601 CHRONIC.R08

Chemical: Acetochlor RfD(Chronic): .02 mg/kg bw/day NOEL(Chronic): 2 mg/kg bw/day
RfD(Ac ute): 1.5 mg/kg bw/day NOEL(Acute): 150 mg/kg bw/day Date created/last modified: 01

- 16

- 2013/12:06:32 Program ver. 3.16, 03

- 08

- d

Comment: Run with new commodities at tolerance & 100% CT

--------------------------------------------------------------- -------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101052000 1A Beet, sugar 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 0101052001 1A Beet, sugar

- babyfood 0.020000 1.000 1.000 new ro

Full comm ent: new rot crop use; 1/2 LOQ; 100% CT 0101053000 1A Beet, sugar, molasses 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 0103296000 1C Potato, chips 0.020000 1.000 1.0 00 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 0103297000 1C Potato, dry (granules/ flakes) 0.020000 6.500 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT; PF used 0103297001 1C Potato, dry (gr anules/ flakes)

- b 0.020000 6.500 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT; PF used
0103298000 1C Potato, flour 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ ; 100% CT 0103298001 1C Potato, flour

- babyfood 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 0103299000 1C Potato, tuber, w/peel 0.020000 1.000 1.000 new ro

Full co mment: new rot crop use; 1/2 LOQ; 100% CT 0103299001 1C Potato, tuber, w/peel

- babyfood 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 0103300000 1C Potato, tuber, w/o peel 0.020000 1.000 1 .000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 0600347000 6 Soybean, seed 1.000000 1.000 1.000 new to

Full comment: new tol; tol; 100% CT 0600349000 6 Soybean, soy milk 1.000000 1.000 1.000 new to

Full comment: new tol; tol; 100% CT 0600349001 6 Soybean, soy mil k

- babyfood or in 1.000000 1.000 1.000 new to

Full comment: new tol; tol; 100% CT 0600350000 6 Soybean, oil 1.000000 0.200 1.000 new to

Full comment: new tol; tol; 100% CT 0600350001 6 Soybean, o il

- babyfood 1.000000 0.200 1.000 new to

Full comment: new tol; tol; 100% CT 0603030000 6C Bean, black, seed 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT

0603032 000 6C Bean, broad, seed 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 0603034000 6C Bean, cowpea, seed 0.020000 1.000 1.000 new ro

Full comment: new rot cr op use; 1/2 LOQ; 100% CT 0603035000 6C Bean, great northern, seed 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 0603036000 6C Bean, kidney, seed 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 0603038000 6C Bean, lima, seed 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 0603039000 6C Bean, mung, seed 0.02 0000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 0603040000 6C Bean, navy, seed 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 0603041000 6C Bean, p ink, seed 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 0603042000 6C Bean, pinto, seed 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 0603098000 6C Chickpea, seed 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 0603098001 6C Chickpea, seed

- babyfood 0.020000 1.000 1.000 new ro

Full com ment: new rot crop use; 1/2 LOQ; 100% CTAcetochlor (PC C ode 121601 ) Dietary Exposure and Risk Assessment DP #: 40 8112



### Page 17 of 19 0603099000 6C Chickpea, flour 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT
0603182000 6C Guar, seed 0.020000 1.000 1. 000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT
0603182001 6C Guar, seed

- babyfood 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 0603203000 6C Lentil, seed 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 0603256000 6C Pea, dry 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT

0603256 001 6C Pea, dry

- babyfood 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 0603258000 6C Pea, pigeon, seed 0.020000 1.000 1.000 new ro

Full comment: new rot cr op use; 1/2 LOQ; 100% CT 0603348000 6C Soybean, flour 1.000000 0.750 1.000 new to

Full comment: new tol; tol; 100% CT 0603348001 6C Soybean, flour

- babyfood 1.000000 0.750 1.000 new to

Full comment: new tol; tol; 100% CT 1500025000 15 Barley, pearled barley 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 L0Q; 100% CT 1500025001 15 Barley, pearled barley

- babyfood 0.020000 1.000 1.000 new r o

Full comment: new rot crop use; 1/2 L0Q; 100% CT 1500026000 15 Barley, flour 0.020000 0.500 1.000 new ro

Full comment: new rot crop use; 1/2 L0Q; 100% CT; PF used 1500026001 15 Barley, flour

- babyfood 0.020000 0.500 1.000 new ro

Full comment: new rot crop use; 1/2 L0Q; 100% CT; PF used 1500027000 15 Barley, bran 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 L0Q; 100% CT

1500065000 15 Buckwheat 0.020000 1.000 1.000 new ro

Full comment: new rot crop use: 1/2 LOQ; 100% CT
1500066000 15 Buckwheat, flour 0.020000 0.500 1.000 new ro

Full comment: ne w rot crop use: 1/2 LOQ; 100% CT; PF used 1500120000 15 Corn, field, flour 0.020000 0.600 1.000 existi

Full comment: existing use 1500120001 15 Corn, field, flour

- babyfood 0.020000 0.600 1.000 existi

Full comment: existing use 1500121000 15 Corn, field, meal 0.020000 0.600 1.000 existi

Full comment: existing use 1500121001 15 Corn, field, meal

- babyfood 0.020000 0.600 1.000 existi

Full comm ent: existing use 1500122000 15 Corn, field, bran 0.020000 1.000 1.000 existi

Full comment: existing use 1500123000 15 Corn, field, starch 0.020000 0.600 1.000 existi

Full comment: existin g use 1500123001 15 Corn, field, starch

- babyfood 0.020000 0.600 1.000 existi

Full comment: existing use 1500124000 15 Corn, field, syrup 0.020000 1.500 1.000 existi

Full comment: existing use

150012 4001 15 Corn, field, syrup

- babyfood 0.020000 1.500 1.000 existi

Full comment: existing use 1500125000 15 Corn, field, oil 0.020000 0.600 1.000 existi

Full comment: existing use

1500125001 15 Co rn, field, oil

- babyfood 0.020000 0.600 1.000 existi

Full comment: existing use 1500126000 15 Corn, pop 0.020000 1.000 1.000 new to

Full comment: new tol; 1/2 LOQ; 100% CT

1500127000 15 C orn, sweet 0.020000 1.000 1.000 new to

Full comment: new tol; 1/2 LOQ; 100% CT
1500127001 15 Corn, sweet

- babyfood 0.020000 1.000 1.000 new to

Full comment: new tol; 1/2 LOQ; 100% CT

150 0226000 15 Millet, grain 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT
1500231000 15 Oat, bran 0.020000 1.000 1.000 new ro

Full comment: new ro t crop use; 1/2 LOQ; 100% CT
1500232000 15 Oat, flour 0.020000 0.500 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT; PF used
1500232001 15 Oat, flour

- babyfood 0.020000 0.500 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT; PF used 1500233000 15 Oat, groats/rolled oats 0.020000 0.400 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT; PF used 1500233001 15 Oat, gro ats/rolled oats

- babyfood 0.020000 0.400 1.000 new roAcetochlor (PC C ode 121601 ) Dietary Exposure and Risk Assessment DP #: 40 8112



### Page 18 of 19 Full comment: new rot crop use; 1/2 LOQ; 100% CT; PF used 1500323000 15 Rice, white 0.050000 1.000 1.000 1500323001 15 Rice, white

- babyfood 0.050000 1.000 1.000 1500324000 15 Rice, brown 0.050000 1.000 1.000 1500324001 15 Rice, brown

- babyfood 0.050000 1.000 1.000 1500325000 15 Rice, flour 0.050000 1.000 1.000 1500325001 15 Rice, flour

- babyfood 0.050000 1.000 1.000 1500326000 15 Rice, bran 0.050000 1.000 1.000 1500326001 15 Rice, bran

- babyfood 0.050000 1.000 1.000 1500328000 15 Rye, gr ain 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 1500329000 15 Rye, flour 0.020000 0.500 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 1500344000 15 Sorghum, grain 0.050000 1.000 1.000 new to

Full comment: new tol; tol; 100% CT 1500345000 15 Sorghum, syrup 0.050000 1.000 1.000 new to

Full comment: new tol ; tol; 100% CT 1500381000 15 Triticale, flour 0.020000 0.500 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT; PF used 1500381001 15 Triticale, flour

- babyfood 0.020000 0.500 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT; PF used 1500401000 15 Wheat, grain 0.020000 1.000 1.000 existi

Full comment: existing rot crop use; 100% CT 1500401001 15 Wheat, grain

- babyfood 0.020000 1.000 1.000 existi

Full comment: existing rot crop use; 100% CT 1500402000 15 Wheat, flour 0.020000 0.500 1.000 existi

Full comment: existing rot crop use; 100% CT; new PF used

1500402001 15 Wheat, flour

- babyfood 0.020000 0.500 1.000 existi

Full comment: existing rot crop use; 100% CT; new PF used 1500403000 15 Wheat, germ 0.020000 1.000 1.000 existi

Full comment: existing rot crop use; 100% CT 1500404000 15 Wheat, bran 0.020000 1.000 1.000 existi

Full comment: existing rot crop use; 100% CT

1500405000 15 Wild rice 0.050000 1.000 1.000

2002364000 20B Sunflower, seed 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 2002365000 20B Sunflower, oil 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1 /2 LOQ; 100% CT 2002365001 20B Sunflower, oil

- babyfood 0.020000 1.000 1.000 new ro

Full comment: new rot crop use; 1/2 LOQ; 100% CT 2003128000 20C Cottonseed, oil 0.600000 1.000 1.000 new to

F ull comment: new tol; tol; 100% CT 2003128001 20C Cottonseed, oil

- babyfood 0.600000 1.000 1.000 new to

Full comment: new tol; tol; 100% CT 8601000000 86A Water, direct, all sources 0.004840 1.000 1.000

8602000000 86 B Water, indirect, all sources 0.004840 1.000 1.000Acetochlor (PC C ode 121601 ) Dietary Exposure and Risk Assessment DP #: 40 8112



### Page 19 of 19 Attachment 4 Results of Chronic DEEM

- FCID Dietary Exposure Analysis.

U.S. EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for ACETO CHLOR NHANES 2003

- 2008 2

- day

Residue file name: C: \ Documents and Settings \ tmorton \ My Documents \ MyFiles \ DEEM Files \ 121601

Acetochlor \ Acetochlor Adding Rice as a Rot Crop \ 121601 CHRONIC.R08 Adjustment factor #2 used. Analysis Date 01

- 16

- 2013/12:11:47 Residue file dated: 01

- 16

- 2013/12:06:32 Reference dose (RfD, Chronic) = .02 mg/kg bw/day

COMMENT 1: Run with new commodities at tolerance & 100% CT

========================================= ====================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

------------------------------------ -- ------------- ---------------- Total US Population 0.000419 2.1% Hispanic 0.000438 2.2%

Non

- Hisp

- White 0.000407 2.0%

Non

- Hisp

- Black 0.000371 1.9%

Non

- Hisp

- Other 0.000642 3.2% Nursing Infants 0.000297 1.5%

Non

- Nursing Infants 0.001186 5.9%

Female 13+ PREG 0.000392 2.0%

Children 1

- 6 0.001041 5.2%

Children 7

- 12 0.000461 2.3%

Male 13

- 19 0.000313 1.6%

Female 13

- 19/NP 0.000319 1.6%

Male 20+ 0.000337 1.7% Female 20+/NP 0.000355 1.8%

Seniors 55+ 0.000324 1.6%

All Infants 0.000912 4.6%

Female 13

- 50 0.000340 1.7%

Children 1

- 2 0.001244 6.2%

Children 3

- 5 0.000915 4.6%

Children 6

- 12 0.000537 2.7%

Youth 13

- 19 0.000315 1.6%

Adults 20

- 49 0.000359 1.8%

Adults 50

- 99 0.000331 1.7%

Female 13

- 49 0.000342 1.7%

-------------------------------------------------------------------------------