<PAGE>

================================================================================
                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                   Form 10-K/A

(Mark One)

[X]      Annual Report Pursuant to Section 13 or 15(d) of the Securities
Exchange Act of 1934 For the fiscal year ended December 31, 1999, or

         Transition Report Pursuant to Section 13 or 15(d) of the Securities
Exchange Act of 1934 For the transition period from ___________ to ___________

                        Commission file number 000-21615
                                               ------------

                             BOSTON BIOMEDICA, INC.
--------------------------------------------------------------------------------
             (Exact Name of Registrant as Specified in its Charter)

              Massachusetts
----------------------------------------                   04-2652826
    (State or other Jurisdiction of              -------------------------------
     Incorporation or Organization)                     (I.R.S. Employer
            375 West Street,                           Identification No.)
    West Bridgewater, Massachusetts                        02379-1040
----------------------------------------         -------------------------------
(Address of Principal Executive Offices)                   (zip code)

Registrant's telephone number, including area code    (508) 580-1900
                                                     ---------------

           Securities registered pursuant to Section 12(b) of the Act:
                                      None

           Securities registered pursuant to Section 12(g) of the Act:
                     Common Stock, par value $.01 per share

         Indicate by check mark whether the registrant: (1) has filed all
reports required to be filed by Section 13 or 15(d) of the Securities Exchange
Act of 1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days.  Yes   No

         Indicate by check mark if disclosure of delinquent filers pursuant to
Item 405 of Regulation S-K is not contained herein, and will not be contained,
to the best of registrant's knowledge, in definitive proxy or information
statements incorporated by reference in Part III of this Form 10-K or any
amendment to this Form 10-K.

         The aggregate market value of the voting common stock held by
non-affiliates of the registrant at February 29, 2000 was $49,248,992, based on
the closing price of the common stock as quoted on the Nasdaq National Market on
that date.

         As of March 24, 2000 there were 5,441,960 shares of the registrant's
common stock outstanding.

                       Documents Incorporated by Reference
                       -----------------------------------
         Portions of the registrant's definitive proxy statement involving the
election of directors at its 2000 annual meeting, which is expected to be filed
within 120 days after the end of the registrant's fiscal year, are incorporated
by reference into Part III of this report.
================================================================================
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PART I

ITEM 1.  BUSINESS

         Boston Biomedica, Inc. and its wholly-owned subsidiaries (together,
"the Company"), provide products and services for the detection and treatment of
infectious diseases such as AIDS, Lyme Disease, and Viral Hepatitis. The Company
has four business units, which are comparable to operating segments (the terms
"business units" and "operating segments" are used herein interchangeably):

(1)           BBI Diagnostics, an ISO 9001 certified manufacturer of quality
              control and other diagnostic products used to increase the
              accuracy of in vitro diagnostic tests;

(2)           BBI Clinical Laboratories, a leading infectious disease testing
              laboratory, specializing in nucleic acid based testing, tick borne
              diseases, and blood bank confirmatory testing;

(3)           BBI Biotech Research Laboratories, the research and development
              arm of the Company which supplements its support for the other BBI
              business units with research contracts and repository services
              primarily for agencies of the United States government; and

(4)           BBI Source Scientific, an ISO 9001 and EN 46001 certified
              manufacturer of laboratory and medical instruments.

  In addition, the Company is pursuing research and development programs in the
areas of Pressure Cycling Technology ("PCT") and drug discovery, with the goals
of introducing new solutions for improving blood plasma safety, specimen
preparation in nucleic acid testing, and treatment of infectious diseases.

         The Company was organized in Massachusetts in 1978, and commenced
significant operations in 1986.

         In July 1999, the Company announced a major reorganization and the
formation of a corporate function. Pursuant to this reorganization a Senior
Vice President and General Manager was appointed for each business unit,
reporting to the President & Chief Operating Officer. The responsibility of
the General Manager is to achieve the agreed upon goals and plan of the
business unit. The primary focus of corporate is to oversee the business
units and guide them according to the strategic direction of the Company.

         In September 1999, the Company moved its research and development
activities in PCT from leased laboratory space in Woburn, Massachusetts to its
BBI Biotech facility in Gaithersburg, Maryland. This was done to allow the
scientific team working on PCT to have easy and open access to the molecular and
cellular biology capabilities at BBI Biotech, as well as to reduce operating
costs and promote efficiencies.

         In October 1999, the Company formed a new, wholly-owned subsidiary,
Panacos Pharmaceuticals, Inc., ("Panacos"), a Delaware corporation. All of the
Company's technology related to its drug discovery and vaccine programs,
consisting primarily of patents and related sponsored research agreements, were
transferred to Panacos effective January 2000. Management intends to sell a
substantial portion of Panacos to third party investors in order to obtain the
substantial amount of capital required to progress to more advanced stages of
drug development including human clinical trials. If successful in raising
capital, the Company plans to become a less than 50% shareholder in Panacos,
give up operational control, and switch to the equity method of accounting for
its investment, as opposed to consolidation accounting.

         The Company's strategy is to leverage its scientific capabilities in
microbiology, immunology, virology, and molecular biology to (1) capitalize on
both the emerging end-user market for quality control products, and the
molecular testing market, (2) develop new products and services, (3) enhance
technical leadership, (4) capitalize on complementary business operations, and
(5) pursue strategic acquisitions and alliances.


                                      -2-
<PAGE>

Industry Overview

         Infectious Disease Test Kits and Testing Methods. Test kits contain in
one compact package all of the materials necessary to run a test for an
infectious disease. These materials include disposable diagnostic components,
instructions, and reaction mixing vessels (generally 96-well plates or test
tubes) that are coated with the relevant infectious disease antigens, antibodies
or other materials. To perform the test typically, either a technician or a
specially designed instrument mixes the solutions from the test kit with human
blood specimens in a specific sequence according to the test kit instructions.
The mixture must then "incubate" for up to 18 hours, during which time a series
of biochemical reactions trigger signals (including color, light or radioactive
count), that indicate the presence or absence and amount of specific markers of
the particular disease in the specimen.

         Test kits generally employ one of three methods for infectious disease
testing: microbiology, immunology or molecular biology. Traditional microbiology
tests use a growth medium that enables an organism, if present, to replicate and
be detected visually. Immunology tests detect the antigen or antibody, which is
an indicator (marker) of the pathogen (e.g., virus, bacterium, fungus or
parasite). Molecular diagnostic methods, such as the polymerase chain reaction
("PCR"), test for the presence of nucleic acids (DNA or RNA) that are specific
to a particular pathogen.

         Most infectious disease tests currently use microbiological or
immunological methods. However, molecular diagnostic methods are increasingly
being used in research and clinical laboratories worldwide. The Company believes
that the advent of molecular diagnostic methods will complement rather than
diminish the need to test by microbiological and immunological procedures,
because different test methods reveal different information about a disease
state. The Company anticipates that as new test methods become more widespread,
they will account for a larger portion of the Company's business.

         Quality Control for In Vitro Diagnostic Test Kits. Customers employ
quality control products in order to develop and use test kits (both infectious
and non-infectious). Quality control products help ensure that test kits detect
the correct analyte ("specificity"), detect it the same way every time
("reproducibility" or "precision"), and detect it at the appropriate levels
("sensitivity"). The major element of this quality control process is the
continuous evaluation of test kits by the testing of carefully characterized
samples that resemble the donor or patient samples routinely used with the test.
Quality control is used in both the infectious and non-infectious disease
markets, although currently it is not as prevalent among end-users of infectious
disease test kits.

         The market for quality control products consists of three main customer
groups : (i) manufacturers of test kits, (ii) regulatory agencies that oversee
the manufacture and use of test kits, and (iii) end-users of test kits, such as
hospitals, clinical reference laboratories and blood banks.

Company Products and Services

Overview

         Through its business unit BBI Diagnostics, the Company offers a broad
array of "Diagnostic Products," for in vitro diagnostic use, consisting of
Quality Control Panels, Accurun(R) Run Controls and Diagnostic Components, all
used in connection with infectious disease testing. Diagnostic Products are used
throughout the entire test kit life cycle, from initial research and
development, through the regulatory approval process and test kit production, to
training, troubleshooting and routine use by end-users. The Company's Quality
Control Panels, which combine human blood specimens with comprehensive
quantitative data useful for comparative analysis, help ensure that test kits
are as specific, reproducible, and sensitive as possible. The Company's
Accurun(R) Run Controls enable end-users of test kits to confirm the validity of
results by monitoring test performance, thereby minimizing false negative test
results and improving error detection. In addition, the Company provides
Diagnostic Components, which are custom processed human plasma and serum
products, to test kit manufacturers.


                                      -3-
<PAGE>

         Through its wholly-owned subsidiary, BBI Source Scientific, Inc., ("BBI
Source"), the Company designs, manufactures and markets "Laboratory
Instruments", consisting of readers and washers and other small medical devices.
These instruments are used in hospitals and clinics, and in research,
environmental and food testing laboratories. Utilizing a common hardware
technology platform, these instruments are used in connection with the
performance of an IN VITRO diagnostics test, including reading the test result.

         Through another wholly-owned subsidiary, BBI Clinical Laboratories,
Inc. ("BBICL") the Company provides specialty clinical laboratory services that
include both routine and sophisticated infectious disease testing in
microbiology, immunology and molecular biology. BBICL seeks to focus its
laboratory services in those advanced areas of infectious disease testing
requiring special expertise.

         BBI Biotech Research Laboratories, Inc., ("BBI Biotech"), another
wholly-owned subsidiary, is the R&D "arm" of the Company, helping to develop new
products and services for the other business units. BBI Biotech seeks to obtain
government grants and other research support wherever possible to help fund the
cost of this R&D. In addition, BBI Biotech provides repository services for the
United States government, and other commercial services for laboratories and
test kit manufacturers.

         During each of the last three fiscal years, each of the Company's
operating segments contributed at least 15% of the Company's consolidated
revenue, with the exception of BBI Source in fiscal 1997 and 1999 and the
"Other" segment in fiscal 1999. The Company's Consolidated Financial Statements
set forth in Item 8 of this report provide financial information relating to
each of the Company's operating segments.

Diagnostic Products

         The Company manufactures its Diagnostic Products from human plasma and
serum that are obtained from nonprofit and commercial blood centers, primarily
in the United States. The Company has acquired and developed an inventory of
approximately 30,000 individual blood units and specimens (with volumes ranging
from 1 ml to 800 ml) which provides most of the raw material for its products.
Within the Diagnostic Products class are two groups: Quality Control Products,
consisting of QC Panels and Accurun(R) Run Controls, and Diagnostic Components.

         Quality Control Panels

         Quality Control Panels consist of blood products characterized by the
presence or absence of specific disease markers and a data sheet containing
comprehensive quantitative data useful for comparative analysis. These Quality
Control Panels are designed for measuring overall test kit performance and
laboratory proficiency, as well as for training laboratory professionals. The
Company's data sheets, which contain comprehensive quantitative data useful for
comparative analysis, are an integral part of its Quality Control Panels. These
data sheets are created as the result of extensive testing of proposed panel
components in both the Company's laboratories and at major testing laboratories
on behalf of the Company in the United States and Europe, including national
public health laboratories, research and clinical laboratories and regulatory
agencies. These laboratories are selected based on their expertise in performing
the appropriate tests on a large scale in an actual clinical laboratory setting;
this testing process provides the Company's customers with the benefit that the
Quality Control Panels they purchase from the Company have undergone rigorous
testing in actual clinical laboratory settings. In addition, the Company
provides information on its data sheets on the reactivity of panel components in
all FDA licensed test kits and all leading European test kits for the target
pathogen, as well as for all other appropriate markers of this pathogen. For
example, the Company's HIV panel data sheets include anti-HIV by IFA, ELISA and
western blot; HIV antigen by ELISA; and HIV RNA by several molecular diagnostic
procedures. The Company's data sheets require significant time and scientific
expertise to prepare. The following table describes the types of Quality Control
Panel products currently offered by the Company:


                                      -4-
<PAGE>

<TABLE>
<CAPTION>
                                                       Quality Control Panels
----------------------------------------------------------------------------------------------------------------------------------
      Product Line                     Description                              Use                          Customers
----------------------------------------------------------------------------------------------------------------------------------
<S>                       <C>                                     <C>                              <C>
Seroconversion Panels     Plasma samples collected from a         Compare the clinical             Test kit manufacturers and
                          single individual over a specific       sensitivity of competing         regulators.
                          time period showing conversion from     manufacturers' test kits,
                          negative to positive for markers of     enabling the user to assess
                          an infectious disease.                  the sensitivity of a test in
                                                                  detecting a developing
                                                                  antigen/antibody.
----------------------------------------------------------------------------------------------------------------------------------
Performance Panels        A set of 10 to 50 serum and plasma      Determine test kit performance   Test kit manufacturers and
                          samples collected from many different   against all expected levels of   regulators.
                          individuals and characterized for the   reactivities in the evaluation
                          presence or absence of a particular     of new, modified and improved
                          disease marker.                         test methods.
----------------------------------------------------------------------------------------------------------------------------------
Sensitivity Panels        Precise dilutions of human plasma or    Evaluate the low-end             Test kit manufacturers.
                          serum human plasma or serum             analytical sensitivity of a
                          containing a known amount of an         test kit.
                          infectious disease marker as
                          calibrated against international
                          standards.
----------------------------------------------------------------------------------------------------------------------------------
Qualification Panels      Dilutions of human plasma or serum      Demonstrate the consistent       Clinical reference
                          manifesting a full range of             lot-to-lot performance of test   laboratories, blood banks,
                          reactivities in test kits for a         kits, troubleshoot problems,     and hospital laboratories.
                          specific marker.                        evaluate proficiency, and
                                                                  train laboratory technicians.
----------------------------------------------------------------------------------------------------------------------------------
OEM Panels                Custom-designed Qualification Panels    Train laboratory personnel on    Custom designed with test kit
                          for regulators and test kit             new test kits or equipment.      manufacturers and regulators
                          manufacturers for distribution to                                        as an end-user product or for
                          customers or for internal use.                                           internal use.
----------------------------------------------------------------------------------------------------------------------------------
Verification Panels       Verification Panels contain naturally   Verify accuracy and ensure       Clinical reference
                          occurring undiluted samples at          that reagents perform to         laboratories, blood banks,
                          varying titers.                         expectation:  also used to       hospital laboratories.
                                                                  troubleshoot system problems
                                                                  and to document problem
                                                                  resolution.
----------------------------------------------------------------------------------------------------------------------------------
</TABLE>

         The Company first introduced Quality Control Panels in 1987. The
Company currently offers a broad range of Quality Control Panels that address a
variety of needs of manufacturers and regulators of test kits as well as blood
banks, hospitals, clinical laboratories and other end-users. Prices for the
Company's quality control seroconversion, performance and sensitivity panels
range from $450 to $2,000 each, and its qualification, OEM, and verification
panels generally range from $100 to $200 per panel.


                                       -5-
<PAGE>

         Seroconversion and performance panels are comprised of unique and rare
plasma specimens obtained from individuals during the short period of time when
the markers for a particular disease are converting from negative to positive.
As a result, the quantity of any such panel is limited, so that the Company must
replace these panels as they sell out with another panel comprised of different
specimens from a different individual, equally unique and rare. The Company
believes that its inventory and relationships with blood centers affords it a
competitive advantage in acquiring such plasma for replacement panels and
developing new products to meet market demand. However, the Company cannot be
certain that it will be able to continue to obtain such specimens.

         Quality Control Panels currently span the immunologic markers for AIDS
(i.e., HIV), Hepatitis (A, B and C), Lyme Disease and ToRCH (Toxoplasma,
rubella, cytomegalovirus and herpes simplex virus).

         Accurun(R) Run Controls

         End-users of test kits utilize run controls to confirm the validity of
results by monitoring test performance, thereby minimizing false negative test
results and improving error detection. Run controls consist of one or more
specimens of known reactivity that are tested with donor or patient samples in
an assay to determine whether the assay is performing within the manufacturer's
specifications. Clinical laboratories generally process their patient specimens
in a batch processing mode, and typically include 25 to 100 specimens to be
tested in each batch (a "run"). Large laboratories may perform several runs per
day, while smaller laboratories may perform only a single run each day, or
sometimes only several runs per week. A clinical laboratory using a run control
will place the run control product in a testing well or testtube, normally used
for a specimen, and will test it in the same manner that it tests the donor or
patient specimens. It will then compare the results generated to an acceptable
range for the run control, determined by the user, to measure whether the other,
unknown specimens are being accurately tested. The run control result must be
within the acceptable range to be considered valid. This is often tracked
visually using what is known as a Levey-Jennings chart. Depending upon a
particular laboratory's quality control practices, it may use several Run
Controls on each run or it may simply use a run control in a single run at the
beginning and end of the day.

         The Company's AccuChart(TM) tracking and charting software, used as
part of a laboratory's quality assurance program, runs on a personal computer
and is designed to provide the data tracking capability needed to document
laboratory performance.

         The Company's Accurun(R) family of products is targeted at the emerging
market of end-users of infectious disease test kits. The Company believes that
it offers the most comprehensive line of run controls in the industry, and that
its Accurun(R) products, in combination with its Quality Control Panel products,
provide an extensive line of products for quality assurance in infectious
disease testing. The Company intends to continue to expand its line of
Accurun(R) products, thereby providing its customers with the convenience and
cost effectiveness of a single supplier for independent run controls.

         The Company introduced its first four Accurun(R) Run Control products
in the fourth quarter of 1993 and has since developed and released for sale an
additional 46 Accurun(R) products. Two products have been discontinued, for a
total of 48 Run Controls available as of December 31, 1999. The majority of
these products are available for diagnostic purposes; the others currently are
limited to research use. Current Accurun(R) Run Control products generally range
in price from $5 to $60 per milliliter and are described in the following table.


                                      -6-
<PAGE>

<TABLE>
<CAPTION>
                                             ACCURUN(R) RUN CONTROLS
----------------------------------------------------------------------------------------------------------------------------------
             Product                          Description               Number of Products            Primary Customers
----------------------------------------------------------------------------------------------------------------------------------
<S>                                 <C>                                        <C>           <C>
Accurun 1(R) Multi Marker           Multi-marker run controls for              12            Blood banks, plasma centers,
Positive Controls                   diagnostic immunological tests                           hospitals and clinical labs
----------------------------------------------------------------------------------------------------------------------------------
Accurun Immunological Positive      Single marker run controls for             23            Hospitals and clinical labs
Controls                            diagnostic immunological tests
----------------------------------------------------------------------------------------------------------------------------------
Accurun Nucleic Acid Positive       Single Marker run controls for              5            Research and specialty labs
Controls                            amplified nucleic acid tests
----------------------------------------------------------------------------------------------------------------------------------
Accurun Reference Nucleic Acid      Run controls calibrated to the              2            International plasma manufacturers
Controls                            World Health Organization                                and blood centers
                                    standard.
----------------------------------------------------------------------------------------------------------------------------------
Accurun Negative Controls           Negative run controls for                   6            All labs
                                    immunological and nucleic acid
                                    testing
----------------------------------------------------------------------------------------------------------------------------------
</TABLE>

         All of the Company's Accurun(R) Run Controls for diagnostic use require
either FDA premarket clearance (a 510(k)) or validation studies (if the products
are exempt from FDA submission requirements under the FDA Modernization Act of
1997), prior to being marketed for diagnostic use. As of March 1, 2000, a total
of 12 products in the Accurun 1(R) line and 18 single analyte Accurun(R)
controls have either received 510(k) clearance or have been validated.

         Diagnostic Components

         Diagnostic Components are the individual materials supplied to
infectious disease test kit manufacturers and combined (often after further
processing by the manufacturer) with other materials to become the various fluid
components of the manufacturer's test kit. The Company supplies Diagnostic
Components in four product lines: Normal Human Plasma, Normal Human Serum,
Basematrix, and Characterized Disease State Serum and Plasma. Normal Human
Plasma and Serum are both the clear liquid portion of blood which contains
proteins, antibodies, hormones and other substances, except that the Serum
product has had the clotting factors removed. Basematrix, the Company's
proprietary processed serum product that has been chemically converted from
plasma, is designed to be a highly-stable, lower cost substitute for most normal
human serum and plasma applications. Characterized Disease State Serum and
Plasma are collected from specific blood donors pre-selected because of the
presence or absence of a particular disease marker. The Company often customizes
its Diagnostic Components by further processing the raw material to meet the
specifications of the test kit manufacturer. The Company's Diagnostic Components
range in price from $0.25 to $60 per milliliter, with the majority selling
between $0.50 and $5 per milliliter.


                                      -7-
<PAGE>

Laboratory Instruments

         BBI Source, the Laboratory Instrumentation operating segment,
designs, manufactures and markets laboratory instruments and other small
medical devices used in hospitals and clinics and in research, environmental
and food testing laboratories. These instruments are generally sold on a
private-label or OEM basis for other companies utilizing a common hardware
technology platform. The instruments manufactured by the Company use advanced
optical detection methods (luminescence, fluorescence, reflectance,
photometry), robotics, fluidics, and unique software, all of which are
desired by customers reselling or supplying state-of-the-art instrumentation
systems to laboratories worldwide in various applications.

         Most of the Laboratory Instrumentation products currently being offered
have been commercialized since 1985 and were primarily developed in conjunction
with IN VITRO diagnostics test kit manufacturers. BBI Source hopes to attract
development partners for new prototype products. Management believes that these
products address important market segments in biomedical and clinical diagnostic
testing and in environmental monitoring and food testing research. The BBI
Source product line currently includes the following:

         MicroChem(R) Photometer. A compact, low-cost, photometer designed for
immunoassay and general chemistry applications.

         ChemStat(R) Automated Photometer. A high-speed, automated photometer
with a sample capacity of 95 tubes and a read rate of one sample per second.
This product is suited for high-volume processing.

         E/LUMINA(R) II Luminescence Analyzer. A flexible luminometer for both
"flash" and "glow" luminescence methods, this automated system reads up to 114
samples and reports final results.

         EXECWASH(R) Washing System. An automated immunoassay washing system
that can be quickly configured by the user to wash different solid-phase assay
formats by a propriety manifold design. The EXEC-WASH is fully compatible with a
variety of other Company products, such as the ChemStat and the E/LUMINA II
Luminescence Analyzer.

         Protocol Design Software System. A development tool for researchers and
assay manufacturers, the program operates under Microsoft(R) Windows and serves
as the master programming center for EXEC-WASH systems to create fluid handling
protocols.

         Verif-Eye(R) A reflectance reader for rapid, reliable results for use
in research and development or process inspection and verification.

Services

         The Company seeks to focus its specialty laboratory services in both
the clinical reference laboratory testing and advanced biomedical research
areas. The Company concentrates its services in those areas of infectious
disease testing which are complementary to its quality control and diagnostic
products businesses.

         Specialty Clinical Laboratory Testing

         BBICL, the Clinical Laboratory Services operating segment, operates an
independent specialty clinical reference laboratory that performs both routine
and sophisticated infectious disease testing in microbiology, immunology and
molecular biology, with special emphasis in AIDS, Viral Hepatitis, Lyme and
other tick borne diseases, and comfirmatory testing for the blood bank industry.
The Company's specialty clinical laboratory combines traditional microbiology,
advanced immunology, and current molecular diagnostic techniques, such as PCR
and bDNA, to detect and identify microorganisms, their antigens and related
antibodies, and their nucleic acids (i.e., DNA and RNA).


                                      -8-
<PAGE>

         Specimens are picked up daily from customers, primarily by BBICL's
courier staff, and are brought to the laboratory in New Britain, Connecticut for
testing. There, they are received, accessioned, scheduled, and then tested.
Results are returned to customers by fax, remote printers, data transmission and
hard copy. BBICL emphasizes accuracy and turnaround time along with competitive
pricing as keys to customer satisfaction. Customers include blood banks,
physicians, clinics, hospitals and other clinical/research laboratories.

         Contract Research and Services

         The BBI Biotech operating segment offers a variety of research services
in molecular biology, cell biology and immunology to governmental agencies,
diagnostic test kit manufacturers and biomedical researchers. Molecular biology
services include DNA extractions and sequencing, recombinant DNA support, probe
labeling and custom nucleic acid amplification assays. Cell biology and
immunology services include sterility testing, virus infectivity assays,
cultivations of virus or bacteria from clinical specimens, preparation of viral
or bacterial antigens and custom western blot assays.

         The Company currently provides contract research services under several
contracts and grants. These services are primarily related to infectious disease
diagnostics, in support of the products and services that the Company wishes to
develop. Current contracts include the following: clinical trials support for
candidate HIV vaccines; identification and DNA sequencing of human genes
involved in neurological disorders, development of PCR based assays for
Babesiosis and Transfusion Transmitted Virus, and microtiter plate assays for
HIV-1 genotyping.

         Blood Processing and Repository Services

          Since 1983, BBI Biotech has provided blood processing and repository
services for the National Cancer Institute ("NCI"), also a part of the National
Institutes of Health ("NIH"). The repository stores over 6,000,000 specimens and
processes or ships up to several thousand specimens per week in support of
various NIH cancer and virus research programs. In 1997, BBI Biotech was awarded
a five-year (including renewal options) NCI repository contract with aggregate
payments of up to $4.8 million. In 1998, BBI Biotech received a six-year $2.9
million repository contract (including five one-year extension options) with the
National Heart, Lung and Blood Institute of the NIH, and in 1999, it received a
seven-year, $9.6 million repository contract with the National Institute of
Allergy and Infectious Disease. To date all renewal options under these
contracts have been approved, although the Company cannot be certain that any
subsequent options will be exercised.

         Other Services

         Clinical Trials. All four business units conduct clinical trials for
domestic and foreign test kit and device manufacturers. Manufacturers must
collect data for submission to the United States FDA and other countries'
regulatory agencies, and these manufacturers contract with organizations such as
the Company to perform this work. By providing this service, the Company is able
to maintain close contact with test kit and device manufacturers and regulators,
and is able to evaluate new technologies in various stages of development. The
Company believes that the reputation of its laboratory and scientific staff, its
large number of Quality Control Panels, and its inventory of characterized serum
and plasma specimens assist the Company in marketing its clinical trial services
to its customers. The Company has performed clinical trials for a number of
United States and foreign test kit and device manufacturers seeking to obtain
FDA approval for their infectious disease test kits.

         Laboratory Instrumentation Services. BBI Source offers services to
design, develop, manufacture and distribute laboratory instruments to companies
seeking to market biomedical products manufactured under government-approved
manufacturing practices. These services range in complexity from consulting to
full system development and distribution.

         After-sales Service. BBI Source also provides after-sales service.
Management believes that after-sales service is a major marketing advantage in
many of the Company's markets, since many of the Company's customers do not
maintain their own full service departments. Servi-Trak(R), a proprietary
software program, is a key element of this after-sales service. The Company's
service department is located at BBI Source's facility in Garden Grove,
California. The


                                      -9-
<PAGE>

Company utilizes an independent third party contractor located in Giessen,
Germany, to provide a fully functional European service and support center.

         Drug Screening Program. As a subcontractor for an NIH AIDS grant held
by the University of North Carolina at Chapel Hill, the Company has established
an anti-HIV drug screening program to test a large number of natural products
(largely plant derivatives) to determine whether they inhibit HIV replication in
an in vitro assay system. These in vitro assays are also offered as a service to
researchers and pharmaceutical companies who wish to test various candidate
anti-viral agents for anti-HIV activity. The drug screening program and in vitro
assays are now offered through the Company's newly formed subsidiary, Panacos
Pharmaceuticals, Inc.

Research and Development

         The Company's research and development effort is focused on (i) the
development of new and improved Quality Control Products (Panels and Accurun(R))
for the emerging end-user market and the in vitro diagnostics market, (ii) the
expansion of its infectious disease testing services using PCR and other
amplification assays, (iii) the design and development of new laboratory
instruments and mechanical and optical detection techniques, emphasizing its
Verif-Eye reflectance reader, (iv) the development of pressure cycling
technology ("PCT") for nucleic acid purification and pathogen inactivation, and
(v) the determination of the mechanism of action and performance of initial
toxicity studies on its lead compounds in the Company's drug discovery program
("Panacos"). The Company has 36 full or part-time employees involved in its
research and development effort. As announced in 1998, at the time of its
acquisition of BioSeq, Inc., the Company has significantly increased spending on
research and development both in whole dollars and as a percentage of revenue in
1999 as compared to 1998. See "Management's Discussion and Analysis of Financial
Condition and Results of Operations -- Results of Operations." The Company's
research scientists work closely with sales, marketing, manufacturing,
regulatory and finance personnel to identify and prioritize the development of
new products and services. Whenever it can, the Company seeks to fund its
research and development activities from grants provided by various agencies and
departments of the United States government. See also "Contract Research and
Services."

         Quality Control Products. In the area of Quality Control Products, the
Company's product development activities center on the identification and
characterization of materials for the manufacture of new products and the
replacement of sold-out products. During 1999, the Company introduced 14 new
Seroconversion, Performance, and Qualification Panel products, 43 OEM Panels, as
well as 13 new Accurun(R) Run Controls. The Company is developing new Quality
Control Products for use with both immunological and molecular diagnostic tests
for subtypes and variants of HIV, HCV and HBV, and a variety of controls
targeted for leading instrument platforms. The Company has increased the number
of Quality Control Products it offers from approximately 20 products in 1990 to
more than 200 in 1999.

         Infectious Disease Tests. The Company also develops new and improved
infectious disease tests, which the Company believes offer potential for above
average profit, for sale by the Clinical Laboratory Services operating segment.
Current emphasis is on additional PCR and other amplification technology based
tests for infectious disease diagnostics, beyond the Company's current offerings
of assays for the pathogens of AIDS, Lyme Disease, Viral Hepatitis, and Herpes,
and for the direct detection of other infectious agents in blood, tissues and
other bodily fluids.

         Laboratory Instruments. The Company's product development activities
related to laboratory instruments are centered on additional configurations of a
"reflectance" reader to produce objective results from rapid in vitro diagnostic
tests. In addition, the Company continues to work on applications for existing
products to broaden their utilization.

         Pressure Cycling Technology. BBI BioSeq, a wholly-owned subsidiary of
the Company, owns patent pending technology based on PCT. PCT research is
primarily focused in two areas: (1) nucleic acid extraction and purification
from target pathogens in connection with sample preparation for PCR or other
molecular testing; and (2) pathogen inactivation of blood plasma intended for
transfusion or for further fractionation into transfusion products. See Note 2
to the Company's Notes to Consolidated Financial Statements in Item 8 hereunder
for further details related to the 1998 acquisition of BioSeq, Inc.


                                      -10-
<PAGE>

         Drug Discovery. In August 1998, the Company hired a Vice President,
Biotheraputics to direct its drug discovery and development efforts. In
collaboration with Dr. K.H. Lee of the School of Pharmacy, University of
North Carolina at Chapel Hill ("UNC"), the Company conducts research relating
to compounds, pharmaceutical compositions, therapeutic methods, and vaccine
preparations, primarily in the HIV field. The Company owns, jointly with UNC,
five United States patents related to this drug discovery program. Two
additional United States patent applications and foreign applications for all
five of the joint patents are pending.

         In April 1999, the Company increased its commitment to directly support
the drug discovery program at UNC, in which a full-time, post-doctoral research
scientist and two of Dr. Lee's doctoral students are working to develop
synthetic derivatives of anti-HIV compounds that have been discovered pursuant
to the Company's joint collaboration with UNC. These research scientists are
also working to introduce modifications to these derivatives in an effort to
make them more soluble, less toxic, or otherwise enhance their anti-viral
properties. UNC has licensed to the Company exclusive worldwide rights to the
five patents awarded to the Company and UNC. Two compounds covered under these
patents have exhibited therapeutic indices in in vitro test model systems in
excess of those recorded for AZT under comparable test conditions. Under this
license, the Company will also have the rights to any new anti-HIV compounds or
derivatives developed in the course of this sponsored research, provided the
Company obtains certain regulatory approvals from the FDA.

         In October 1999, the Company formed a new, wholly-owned subsidiary,
Panacos Pharmaceuticals, Inc., ("Panacos") a Delaware corporation. All of the
technology, intellectual property, sponsored research agreements, and related
rights from the drug discovery business unit were transferred to Panacos
effective January 2000. Management intends to sell a substantial portion of
Panacos to third party investors in 2000 in order to obtain the substantial
amount of capital required to progress to more advanced stages of drug
development including human clinical trials. If successful in raising capital,
the Company plans to become a less than 50% shareholder in Panacos, relinquish
operational control, and switch to the equity method of accounting for its
investment, as opposed to consolidation accounting.

Sales and Marketing

         The Company's sales and marketing efforts are managed on a business
unit basis. Such activities are directed by a Director of Sales and Marketing
for each unit. Overall, the Company employees 35 people in the sales, marketing,
and customer service functions.

         The Company's marketing strategy is to focus on the needs of its
customers in the infectious disease testing market throughout the entire test
kit life-cycle, from initial research and development, through the regulatory
approval process and test kit production, to training, troubleshooting and
routine use by end-users such as clinical laboratories, hospitals and blood
banks.

         The Company also continues to focus its sales and marketing efforts on
the emerging end-user market for Quality Control Products for infectious disease
test kits. To promote this objective, the Company uses its marketing platform,
known as "Total Quality System" ("TQS"). TQS is a package of Quality Control
Products, including the Company's Accurun(R) Run Controls and AccuChart Quality
Control Software, that is designed to provide test kit end-users with the
products needed in an overall quality assurance program. These products enable
laboratories to evaluate each of the key elements involved in the testing
process: the test kit, laboratory equipment, and laboratory personnel. The
Company believes that TQS effectively addresses the need for end-users to ensure
the accuracy of their test results. The Company intends to continue to expand
its sales and marketing activities with respect to its Accurun(R) line of run
control products. In addition, the Company continues to expand the Accurun
product line to support the high growth nucleic acid testing market, and to
capitalize on the worldwide implementation of new technology to improve the
safety of blood products.

         The Company's Diagnostic Products are currently sold through a
combination of telephone, mail, third party distributors and direct sales
efforts. Domestically, Diagnostic Products are sold through a direct sales force
led by a Sales and Marketing director. The sales force consists of two sales
group managers and 12 sales representatives. Internationally, the Company
distributes its Diagnostic Products both directly and through 22 independent
distributors located in Japan, Australia, South America, Southeast Asia, Israel
and Europe. The Company's international sales


                                      -11-
<PAGE>

manager oversees the Company's foreign distributors. The Company's Laboratory
Instruments are sold through a direct domestic and international sales force
consisting of one director and one sales representative.

         The Company's Specialty Clinical Laboratory Testing services are
marketed primarily through a direct domestic sales force, which consists of nine
sales representatives managed by one regional manager, and a sales and marketing
director. The sales representatives are located throughout the eastern,
mid-western and western United States and are supported internally by a client
services representative.

         The Company emphasizes high quality products and services, technical
knowledge, and responsiveness to customer needs in its marketing activities for
both products and services. The Company educates its distributors, customers and
prospective customers about its products through a series of detailed marketing
brochures, technical bulletins and pamphlets, press releases and direct mail
pieces. These materials are supplemented by occasional advertising in industry
publications, technical presentations, and exhibitions at local, national and
international trade shows and expositions. During 1999, the Company introduced a
new product information library on the Company web site (www.bbii.com) allowing
customers, field sales personnel and international distributors immediate access
to detailed product information and marketing literature.

Seasonality

         Historically, the Company's results of operations have been subject to
quarterly fluctuations due to a variety of factors, primarily customer
purchasing patterns, driven by end-of-year expenditures, and seasonal demand
during the summer months for certain laboratory testing services. In particular,
the Company's sales of its off-the-shelf Diagnostic Products typically have been
highest in the fourth quarter and lowest in the first quarter of each fiscal
year, whereas OEM product sales may peak in any quarter of the year, depending
on the customer's underlying production cycle for their product. Specialty
Clinical Laboratory Services have generally reached a seasonal peak during the
third quarter, coinciding with the peak incidence of Lyme Disease. Research
Contracts are generally for large dollar amounts spread over one to five-year
periods, and upon completion, frequently do not have renewal phases. As a
result, these contracts can cause large fluctuations in revenue and net income.
In addition to staff dedicated to internal research and development, certain of
the Company's technical staff work on both Contract Research for customers and
Company sponsored research and development. The allocation of certain technical
staff to such projects depends on the volume of Contract Research. As a result,
research and development expenditures fluctuate due to increases or decreases in
contract research performed.

Customers

         The Company's customers for Diagnostic Products consist of four major
groups: (1) international diagnostics and pharmaceutical manufacturing
companies, such as Abbott Diagnostics, Behring, Biorad, Chiron, Dade-Behring,
DiaSorin, Fujirebio, Hoffman LaRoche, Ortho Diagnostics (Johnson & Johnson), and
Sanofi Diagnostics. (2) regulatory agencies such as the United States FDA, the
British Public Health Laboratory Service, the French Institut National de la
Transfusion Sanguine, and the German Paul Ehrlich Institute, (3) national and
international proficiency providers such as the College of American Pathologists
and the European Union Concerted Action for Quality Control and (4) end-users of
diagnostic test kits, such as hospital and independent clinical laboratories,
including LabCorp, Quest Diagnostics , public health laboratories and blood
banks, including the American Red Cross, Swiss Red Cross, and United Blood
Services.

         The Company's customers for Laboratory Instruments consist of
international diagnostic and pharmaceutical manufacturing companies and are
generally sold on an OEM basis, for use by hospitals, and clinical and research
laboratories. In addition, Laboratory Instruments are sold directly to
environmental and food testing laboratories, and wineries. Customers include
Mast Immuno Systems, Beckman/Hybritech Inc., Vicam, and Toray Fuji Bionics Inc.
The Company's customers for specialty clinical testing services include hospital
and clinical laboratories, physicians, blood banks, researchers and other health
care providers.


                                      -12-
<PAGE>

         The Company performs specialty testing services for a major state
prison system in connection with a third party laboratory. The Company's
customers for contract research include various agencies of the National
Institutes of Health (NIH) such as the National Institute of Allergies and
Infectious Disease ("NIAIDS"), the National Cancer Institute ("NCI"), and the
National Heart Lung and Blood Institute ("NHLBI").

         The Company does not have long-term contracts with its customers for
Diagnostic Products or its Specialty Clinical Testing Services, which are
generally sold pursuant to purchase orders for discrete purchases. Laboratory
Instruments are generally sold on an OEM basis under short-term contracts with
monthly delivery dates. The Company believes that its relationships with
customers are satisfactory.

         The Company's Consolidated Financial Statements, including the Notes
thereto, set forth in Item 8 of this report provide information relating to the
Company's foreign and domestic sales.

         During the fiscal years 1999, 1998 and 1997, sales to the Company's
three largest customers accounted for an aggregate of approximately 16%, 18% and
20%, respectively, of the Company's net sales, although the customers were not
identical in each period. During the fiscal years 1999, 1998 and 1997, the
combined revenues to all branches of the National Institutes of Health, a United
States Government agency, accounted for approximately 15%, 13% and 13%,
respectively, of total consolidated revenues of the Company. While the Company
believes that the loss of any one of these customers would have an adverse
effect on the Company's results, this risk is partially mitigated by the
diversity of its customer base within the in vitro diagnostics industry and the
different diseases and instrument platforms on which they focus.

Manufacturing and Operations

         The Company manufactures and assembles Diagnostic Products at its
facility in West Bridgewater, Massachusetts. Raw materials (primarily plasma and
serum) are acquired from a variety of vendors and through a program of donor
recruitment, screening, management, and plasma/serum collection and
characterization. Laboratory instruments are manufactured and assembled at the
Company's facility in Garden Grove, California. All important raw materials and
sub-assemblies are acquired from a variety of vendors with multiple sources of
supply.

         The Company operates its specialty clinical laboratory in New Britain,
Connecticut, its research and development laboratory (including PCT and Panacos
activities) in Gaithersburg, Maryland and a repository facility in Frederick,
Maryland. See "Item 2 -- PROPERTIES."

Competition

         The market for the Company's products and services is highly
competitive. Many of the Company's competitors are larger than the Company
and have greater financial, research, manufacturing, and marketing resources.
Important competitive factors for the Company's products include product
quality, price, ease of use, customer service and reputation. In a broader
sense, industry competition is based upon scientific and technical
capability, proprietary know-how, access to adequate capital, the ability to
develop and market products and processes, the ability to attract and retain
qualified personnel, and the availability of patent protection. To the extent
that the Company's products and services do not reflect technological
advances, the Company's ability to compete in its current and future markets
could be adversely affected.

         In the area of Quality Control Products, the Company competes in the
United States with NABI (formerly North American Biologicals, Inc.) in run
controls and quality control panel products, with Dade International, Bio-Rad
Laboratories, Inc., and Blackhawk Biosystems Inc. in run controls, and with a
number of smaller, privately-held companies in quality control panels. In
Europe, in addition to the above, the Dutch Red Cross offers several run control
and panel products. The Company believes that all of these competitors currently
offer a less diverse line of panel and run control products than the Company,
although the Company cannot be certain that these companies will not expand
their product lines.


                                      -13-
<PAGE>

         In the Diagnostic Components area, the Company competes with integrated
plasma collection and processing companies such as Serologicals, Inc. and NABI,
as well as smaller, independent plasma collection centers and brokers of plasma
products. In the Diagnostic Components area, the Company competes on the basis
of quality, breadth of product line, technical expertise and reputation.

         The laboratory instrument manufacturing industry is diverse and highly
competitive. The Company believes its technology base, reputation for
reliability, systems integration and service capabilities provide it with a
competitive advantage over its competitors which include: Dynatech Corp,
Kollsman Manufacturing Company, Inc., Bio-Tek Instruments Inc., Rela Inc. (part
of Colorado Medtech, Inc.) and SeaMed, as well as numerous, smaller companies,
such as Awareness Technology Inc.

         The Clinical Laboratory Services segment competes with large national
reference laboratories, such as LabCorp of America and Quest Laboratories, as
well as several independent regional laboratories, hospital laboratories,
government contract laboratories and large research institutions. The Company
believes that by focusing on the specialty clinical laboratory testing market,
it is able to offer its customers a higher value-added service for the more
complex diagnostic tests than the larger national reference laboratories.

         BBI Biotech competes primarily with BioReliance Corporation and several
universities for research and development contracts and with McKesson
Bioservices, Inc., for repository services.

Intellectual Property

         The Company holds as trade secrets current technology used to prepare
Basematrix and other blood-based products. None of the Company's Diagnostic
Components has been patented. The Company relies primarily on a combination of
trade secrets and non-disclosure and confidentiality agreements to establish and
protect its proprietary rights in these products and related technology. The
Company cannot be certain that others will not independently develop or
otherwise acquire the same, similar or more advanced trade secrets and know-how.

         BBI Source has also relied on trade secrets and proprietary know-how
for its Laboratory Instruments which it protects in part by entering into
confidentiality agreements with persons or parties deemed appropriate by
management. In addition, the Company currently has six issued United States
patents, covering significant aspects of the Company's core instrument
technology and techniques, as well as several electronic and mechanical designs
employed in the Company's products.

         The Company has two United States patents related to its contracts and
services work. Jointly with the Uiversity of North Carolina, at Chapel Hill, the
Company has five additional United States patents relating to compounds,
pharmaceutical compositions, therapeutic methods, and vaccine preparation in
connection with the Company's drug discovery program. Two additional United
States patents and foreign applications for all five of the joint patents are
pending. The Company intends to continue to seek patent protection for
innovations and discoveries arising out of the drug discovery programs.

         The Company has fifteen pending patent applications for its Pressure
Cycling Technology. Several of these have been followed up with foreign
applications, and the Company expects to file additional foreign applications in
2000 relating to Pressure Cycling Technology. On March 14, 2000 the Company
received notice from the United States Patent Office that one of its
applications had been approved and the patent related to pressure cycling
control of chemical reactions was issued to the Company.

         The Company has no reason to believe that its products and proprietary
methods infringe the proprietary rights of any other party. However, the Company
cannot be certain that other parties will not assert infringement claims in the
future.

         BBI(R), Accurun(R), Microchem(R), Chemstat(R), E/LUMINA(R), EXECWASH(R)
and Verif-Eye(R) are registered trademarks of the Company.

Government Regulation


                                      -14-
<PAGE>

         The manufacture and distribution of medical devices, including products
manufactured by the Company that are intended for in vitro diagnostic use, are
subject to extensive government regulation in the United States and in other
countries.

         In the United States, the Food, Drug, and Cosmetic Act ("FDCA")
prohibits the marketing of most in vitro diagnostic products until they have
been cleared or approved by the FDA, a process that is time-consuming,
expensive, and uncertain. In vitro diagnostic products must be the subject of
either a premarket notification clearance (a "510(k)") or an approved premarket
approval application ("PMA"). With respect to devices reviewed through the
510(k) process, a company may not market a device for diagnostic use until an
order is issued by the FDA finding the product to be substantially equivalent to
an existing FDA cleared, and marketed device. A 510(k) submission may involve
the presentation of a substantial volume of data, including clinical data, and
may require a substantial period of review. With respect to devices reviewed
through the PMA process, a company may not market a device until the FDA has
approved a PMA application, which must be supported by extensive data, including
preclinical and clinical trial data, literature, and manufacturing information
to prove the safety and effectiveness of the device.

         The Company's Accurun(R) Run Controls, when marketed for blood donor
screening or diagnostic use, have been classified by the FDA as medical devices
that until 1998 required clearance under the 510(k) process. In 1998, new rules
took effect that exempted unassayed controls intended for use in diagnostic
testing from the requirement for a 510(k) submission. BBI may now label these
products "For In Vitro Diagnostic Use" if they are validated according to the
Company's protocols and manufactured according to cGMP (current Good
Manufacturing Practices, which is FDA guidance for manufacturing processes for
medical devices). The FDA still requires 510(k) clearance for assayed controls,
and controls intended for use in blood screening. The FDA could, in addition,
require that some products be reviewed through the PMA process, which generally
involves a longer review period and the submission of more information to FDA.
The Company cannot be certain that it will obtain regulatory approvals on a
timely basis, if at all. Failure to obtain regulatory approvals in a timely
fashion or at all could have a material adverse effect on the Company.

         As of March 1, 2000, a total of 13 products in the Accurun 1(R) line
and 18 single analyte Accurun(R) controls have either received 510(k)
clearance or have been validated according to the Company's protocols and are
manufactured according to cGMP. Certain of the Company's Accurun(R) Run
Controls are currently marketed "for research use only." The labeling of
these products limits their use to research. It is possible, however, that
some purchasers of these products may use them for diagnostic purposes
despite the Company's intended use. In these circumstances, the FDA could
allege that these products should have been cleared or approved by the FDA,
or validated prior to marketing, and initiate enforcement action against the
Company, which could have a material adverse effect on the Company. The FDA
has issued a Draft Policy Compliance Guideline, which, if it takes effect as
currently issued, will strictly limit the sale of products labeled "for
research use only." The Company is monitoring this situation, and will adapt
its policies as required.

         BBI Source generally obtains 510(k) and CE approval for all laboratory
instrumentation designed and manufactured in its Garden Grove facility.

         The Company is registered as a medical device manufacturer with the FDA
for its Diagnostic Products and Laboratory Instruments and files listings of its
products semi-annually. The Company's facilities in West Bridgewater,
Massachusetts for Diagnostic Products and Garden Grove, California for
Laboratory Instruments are FDA Good Manufacturing Practices (FDA/GMP)
facilities. The Company must maintain high standards of quality in
manufacturing, testing and documentation, and implement strict cGMP guidelines
governing reagent and instrument manufacturing.

         Once cleared or approved, medical devices are subject to pervasive and
continuing regulation by the FDA, including, but not limited to cGMP regulations
governing testing, control, and documentation; and reporting of adverse
experiences with the use of the device. The FDA monitors ongoing compliance with
cGMP and other applicable regulatory requirements by conducting periodic
inspections. FDA regulations require FDA clearance or approval for certain
changes if they do or could affect the safety and effectiveness of the device,
including, for example, new indications for use, labeling changes or changes in
design or manufacturing methods. In addition, both before and after clearance or
approval, medical devices are subject to certain export and import requirements
under the FDCA. Product


                                      -15-
<PAGE>

labeling and promotional activities are subject to scrutiny by the FDA and, in
certain instances, by the Federal Trade Commission. Products may be promoted by
the Company only for their approved use. Failure to comply with these and other
regulatory requirements can result, among other consequences, in failure to
obtain premarket approvals, withdrawal of approvals, total or partial suspension
of product distribution, injunctions, civil penalties, recall or seizures of
products and criminal prosecution.

         The Company believes that its Quality Control Panels are not regulated
by the FDA because they are not intended for diagnostic purposes. The Company
believes that its Diagnostic Components, which are components of in vitro
diagnostic products, may be subject to certain regulatory requirements under the
FDCA and other laws administered by the FDA, but do not require that the Company
obtain a premarket approval or clearance. The Company cannot be certain,
however, that the FDA would agree or that the FDA will not adopt a different
interpretation of the FDCA or other laws it administers, which could have a
material adverse effect on the Company.

         The Company's Diagnostic Products and Laboratory Instruments business
units are both ISO9001 certified, with registration by TUV Rheinland for the
Diagnostic Products unit and British Standard Institute for the Laboratory
Instruments unit. The Laboratory Instrument group is also certified to EN46001,
a set of supplementary requirements applicable to their products.

         Laws and regulations affecting some of the Company's products are in
effect in many of the countries in which the Company markets or intends to
market its products. These requirements vary from country to country. Member
states of the European Economic Area (which is composed of members of the
European Union and the European Free Trade Association) are in the process of
adopting various product and service "Directives" to address essential health,
safety, and environmental requirements associated with the subject products and
services. These "Directives" cover both quality system requirements (ISO Series
9000 Standards and the EN46001 Requirements) and product and marketing related
requirements. In addition, some jurisdictions have requirements related to
marketing of the Company's products. The Company cannot be certain that it will
be able to obtain any regulatory approvals required to market its products on a
timely basis, or at all. Delays in receipt of, or failure to receive such
approvals, or the failure to comply with regulatory requirements in these
countries or states could lead to compliance action, which could have a material
adverse effect on the Company's business, financial condition, or results of
operations.

         The Company's service-related business (clinical trials, infectious
disease testing, and contract research) is subject to other national and local
requirements. The Company's facilities are subject to review, inspection,
licensure or accreditation by some states, national professional organizations
(such as the College of American Pathologists), and other national regulatory
agencies (such as the Health Care Financing Administration). Studies to evaluate
the safety or effectiveness of FDA regulated products (primarily human and
animal drugs or biologics) must also be conducted in conformance with relevant
FDA requirements, including Good Laboratory Practice ("GLP") regulations,
investigational new drug or device regulations, Institutional Review Board
("IRB") regulations and informed consent regulations.

         The Clinical Laboratory Improvement Amendments of 1988 ("CLIA")
prohibits laboratories from performing in vitro tests for the purpose of
providing information for the diagnosis, prevention or treatment of any disease,
or impairment of, or the assessment of, the health of human beings unless there
is in effect for such laboratories a certificate issued by the US Department of
Health and Human Services ("HHS") applicable to the category of examination or
procedure performed.

         The Company currently holds permits issued by HHS (CLIA license),
Centers for Disease Control and Prevention (Importation of Etiological Agents or
Vectors of Human Diseases), the US Department of Agriculture (Importation and
Transportation of Controlled Materials and Organisms and Vectors) and the US
Nuclear Regulatory Commission (in vitro testing with by-product material under
general license, covering the use of certain radioimmunoassay test methods).

         The Company is also subject to government regulation under the Clean
Water Act, the Toxic Substances Control Act, the Resource Conservation and
Recovery Act, the Atomic Energy Act, and other national, state and local
restrictions relating to the use and disposal of biohazardous, radioactive and
other hazardous substances and wastes. The Company is


                                      -16-
<PAGE>

an exempt small quantity generator of hazardous waste and has a US Environmental
Protection Agency identification number. The Company is also registered with the
US Nuclear Regulatory Commission for use of certain radioactive materials. The
Company is also subject to various state regulatory requirements governing the
handling of and disposal of biohazardous, radioactive and hazardous wastes. The
Company has never been a party to any environmental proceeding.

         Internationally, some of the Company's products are subject to
additional regulatory requirements, which vary significantly from country to
country. Each country in which the Company's products and services are offered
must be evaluated independently to determine the country's particular
requirements. In foreign countries, the Company's distributors are generally
responsible for obtaining any required government consents.

Employees

         As of December 31, 1999 the Company employed 288 persons, all of whom
were located in the United States. Of these, 107 persons were employed by the
West Bridgewater, Massachusetts company, 78 by the New Britain, Connecticut
company, 70 by the three Gaithersburg, Maryland companies, and 33 by the Garden
Grove, California company. None of the Company's employees is covered by a
collective bargaining agreement. The Company believes that it has a satisfactory
relationship with its employees.


                                      -17-
<PAGE>

Executive Officers of the Registrant

         The following table sets forth the names, ages and positions of the
    current executive officers of the Registrant as of December 31, 1999:

<TABLE>
<CAPTION>
Name                                     Age       Position
----                                     ---       --------
<S>                                      <C>       <C>
Richard T. Schumacher                    49        Chief Executive Officer and Chairman of the Board
Kevin W. Quinlan                         49        President and Chief Operating Officer; and Director
William R. Prather, R.Ph, M.D.           52        Senior Vice President, Finance and Business Development, Treasurer and
                                                   Director
Graham P. Allaway, Ph.D.                 44        Senior Vice President, Drug Discovery
Patricia E. Garrett, Ph.D.               56        Senior Vice President and General Manager of BBI Clinical Laboratories
Mark M. Manak, Ph.D.                     48        Senior Vice President and General Manager of BBI Biotech
David F. Petersen                        53        Senior Vice President and General Manager of BBI Source
Richard C. Tilton, Ph.D.                 63        Senior Vice President, Science and Technology
Barry M. Warren                          52        Senior Vice President and General Manager of BBI Diagnostics
Kathleen W. Benjamin                     43        Vice President, Human Resources
Richard D'Allessandro                    53        Vice President, Information Technology
Ronald V. DiPaolo, Ph.D.                 55        Vice President, Manufacturing
</TABLE>

         Mr. Schumacher, the Founder of the Company, has been the Chief
Executive Officer and Chairman since 1992 and served as President from 1986 to
August 1999. Mr. Schumacher served as the Director of Infectious Disease
Services for Clinical Science Laboratory, a New England-based medical reference
laboratory, from 1986 to 1988. From 1972 to 1985, Mr. Schumacher was employed by
the Center for Blood Research, a nonprofit medical research institute associated
with Harvard Medical School. Mr. Schumacher received a B.S. in zoology from the
University of New Hampshire.

         Mr. Quinlan, a Director of the Company since 1986, has served as
President and Chief Operating Officer since August 1999. From January 1993 to
August 1999, he served as Senior Vice President, Finance, Chief Financial
Officer and Treasurer. From 1990 to December 1992, he was the Chief Financial
Officer of ParcTec, Inc. a New York-based leasing company. Mr. Quinlan served as
Vice President and Assistant Treasurer of American Finance Group, Inc. from 1981
to 1989 and was employed by Coopers & Lybrand from 1975 to 1980. Mr. Quinlan is
a certified public accountant and received a M.S. in accounting from
Northeastern University and a B.S. in economics from the University of New
Hampshire.

         Dr. Prather, a Director of the Company since 1999, has been Senior Vice
President, Finance and Business Development since July 1999. From January 1999
to August 1999, Dr. Prather served as Senior Vice President, Business
Development. Prior to joining the Company, Dr. Prather was the Senior Health
Care Analyst for the investment banking firm, Cruttenden Roth, Inc., from 1995
to 1998. From 1992 to 1995 he was the Senior Analyst in Health Care for Manning
and Napier Advisors. Dr. Prather earned a B.S. in Pharmacy and an MD at the
University of Missouri - Kansas City and completed a Clinical Research Geriatric
Fellowship at Harvard Medical School. Dr. Prather is a Director of Primed
International, a medical device company and a member of the Advisory Board of
the Canadian Medical Discovery Fund, Inc., a fund of MDS Capital Corp.

         Dr Allaway, has served as Vice President and Senior Vice President,
Drug Discovery since joining the Company in 1998. Prior to that, from 1997 to
1998, he was CEO of Manchester Biotech (UK). From 1990 to 1997, Dr. Allaway
served in various senior management positions including Associate Scientific
Director and Head, Therapeutic Development Group at Progenics Pharmaceuticals,
Inc., in Tarrytown, New York. From 1984 to 1990 Dr. Allaway was a Visiting
Fellow and Visiting Associate at the NIH. Dr. Allaway received an M.A. in
zoology from Oxford University and a Ph.D in virology from the University of
London.


                                      -18-
<PAGE>

         Dr. Garrett has served as Senior Vice President and General Manager of
BBI Clinical Laboratories since August 1999. From 1988 to August 1999, she
served as Senior Vice President, Regulatory Affairs & Strategic Programs. From
1980 to 1987, Dr. Garrett served as the Technical Director of the Chemistry
Laboratory, Department of Laboratory Medicine at the Lahey Clinic Medical
Center. Dr. Garrett earned her Ph.D. from the University of Colorado and was a
postdoctoral research associate at Harvard University, Oregon State University,
Massachusetts Institute of Technology and the University of British Columbia.

         Dr. Manak has served as Senior Vice President and General Manager of
BBI Biotech since August 1999. From 1992 to 1999 he served as Senior Vice
President, Research and Development. From 1980 to 1992, he served as Director of
Molecular Biology and Director of Contracts and Services of Biotech Research
Laboratories. Dr. Manak received his Ph.D. in biochemistry from the University
of Connecticut and completed postdoctoral research work in biochemistry/virology
at Johns Hopkins University.

         Mr. Petersen has served as Senior Vice President and General Manager of
BBI Source since August 1999. From May 1998 to August 1999, he was Vice
President, BBI Source Scientific. Mr. Peterson has 25 years of experience in
operations management and materials planning. Before joining the Company in
1988, he was the Manager of Manufacturing for Matrix Instruments from 1985 to
1988 and previously was Manager of Production and Inventory Control for Farr
Company, Inc. from 1977 to 1985. He is certified in production and inventory
management (CPIM) by the American Production and Inventory Control Society
(APICS). He is also an Assistant Professor at California State University
Dominguez Hills, where he instructs upper division courses in manufacturing
techniques and material resource planning. He holds a B.S. in business
management from the University of LaVerne in LaVerne, California.

         Dr. Tilton has served as Senior Vice President, Science and Technology
since August 1999. Prior to this time he served as Senior Vice President,
Specialty Laboratory Services since the Company's acquisition of BBI Clinical
Laboratories, Inc. ("BBICL") in 1993 and was one of the founders of BBICL,
serving as its President from 1989 to 1993. Dr. Tilton has 25 years of
experience in university hospital clinical microbiology laboratories and is
board certified in medical and public health microbiology. Dr. Tilton received
his Ph.D. in microbiology from the University of Massachusetts.

         Mr. Warren has served as Senior Vice President and General Manager of
BBI Diagnostics since August 1999. From 1993 to 1999, he served as Senior Vice
President, Sales & Marketing. From 1985 to 1993, Mr. Warren served as Group
Director of Marketing of Organon Teknika, a manufacturer of infectious disease
reagents. Mr. Warren received an M.A. in political science from Loyola
University of Chicago and a B.A. from Loyola University.

         Ms. Benjamin has served as Vice President, Human Resources since
January 1999. Prior to her promotion to Vice President, Ms. Benjamin served as
Director of Human Resources and Investor Relations from 1997 to 1999. Prior to
joining the Company in 1997 she was employed by Shields Health Care Group, a
provider of Magnetic Resonance Imaging and radiation oncology, serving as their
Director of Operations from 1992 to 1997. Prior to this time she was an
educator. Ms. Benjamin received her B.S., from the College of Life Sciences and
Agriculture at the University of New Hampshire.

         Mr. D'Allessandro has served as Vice President, Information Technology
since January 1999. Mr. D'Allessandro joined the Company in 1993 as Director,
Management Information Systems and served in that capacity until his promotion
to Vice President. Mr. D'Allessandro has 30 years of experience in data
processing/information systems technology, with a focus on manufacturing and
biotechnology organizations. Mr. D'Allessandro is APICS certified and received
his B.S. in Management Information Systems from Northeastern University.

         Dr. DiPaolo has served as Vice President, Manufacturing since 1997.
From 1993 to 1997, he served as Vice President of Operations. Prior to joining
the Company, from 1986 to 1989, Dr. DiPaolo served as Vice President and General
Manager of the Biomedical Products Division of Collaborative Research, a medical
research products company. From 1975 to 1986, he was employed by DuPont New
England Nuclear, an in vitro test kit manufacturer. Dr. DiPaolo received his
Ph.D. in biochemistry from Massachusetts Institute of Technology and later
completed postdoctoral research at the Eunice Shriver Center in Waltham,
Massachusetts.


                                      -19-
<PAGE>

         Officers are nominated by the Chief Executive Officer and elected by
the Board of Directors.

ITEM 2.  PROPERTIES.

         The Company owns its corporate offices and diagnostic products
manufacturing facility for its BBI Diagnostics operating segment, which is
located in a two-story, 32,000 square foot building in West Bridgewater,
Massachusetts. The Company has been renovating and expanding this facility
during the past three years, and believes that upon completion of renovations,
its facility in West Bridgewater will be sufficient to meet its needs for
several years.

         The Company leases 41,000 square feet of space in Garden Grove,
California where its BBI Source business unit manufactures laboratory
Instruments. The lease continues until February 1, 2002 and the Company has an
option to renew at market rates.

         The Company leases its laboratory facilities in Gaithersburg and
Frederick, Maryland and New Britain, Connecticut. The BBI Biotech segment's
Gaithersburg facility contains 36,500 square feet of custom built laboratory
and office space, and is occupied under a ten-year lease that is due to
expire on October 31, 2007. The Frederick facility contains 36,000 square
feet of primarily repository space and is also occupied by the BBI Biotech
segment, under a seven-year lease that is due to expire on November 30, 2006.
The BBICL business unit occupies the New Britain facility which has 15,000
square feet of usable area, most of which is dedicated to laboratory space.
This lease is due to expire on July 30, 2000; the Company has exercised its
option to renew the lease for an additional five years.

         The Company leased approximately 2,500 square feet of laboratory space
in Woburn, Massachusetts through August 1999.

ITEM 3.  LEGAL PROCEEDINGS.

         There are no material legal proceedings pending against the Company or
its subsidiaries.

ITEM 4.  SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS.

         No matter was submitted during the fourth quarter of fiscal 1999 to a
vote of security holders of the Company.


                                      -20-
<PAGE>

                                     PART II

ITEM 5.  MARKET FOR REGISTRANT'S COMMON EQUITY AND RELATED
         STOCKHOLDER MATTERS.

         The Company completed an initial public offering of its Common Stock,
$.01 par value, (the "Common Stock") on October 31, 1996. The Common Stock is
listed on the Nasdaq National Market under the symbol "BBII".

         The following table sets forth the high and low closing price, by
quarter, during the two most recent fiscal years:

<TABLE>
<CAPTION>
                                                                                     Common Stock Price
                                                                                     ------------------
<S>                                                                              <C>                  <C>
                   Fiscal Year Ended December 31, 1999                            High                  Low
                   -----------------------------------                            ----                  ---

                   First Quarter                                                 $3.375               $2.625
                   -------------                                                 ------               ------

                   Second Quarter                                                $5.313               $2.750
                   --------------                                                ------               ------

                   Third Quarter                                                 $4.562               $3.375
                   -------------                                                 ------               ------

                   Fourth Quarter                                                $4.438               $2.750
                   --------------                                                ------               ------

                   Fiscal Year Ended December 31, 1998
                   -----------------------------------

                   First Quarter                                                 $8.063               $5.125
                   -------------                                                 ------               ------

                   Second Quarter                                                $7.313               $4.500
                   --------------                                                ------               ------

                   Third Quarter                                                 $5.125               $2.500
                   -------------                                                 ------               ------

                   Fourth Quarter                                                $4.375               $2.000
                   --------------                                                ------               ------
</TABLE>

         As of March 24, 2000, there were 20,000,000 shares of Common Stock
authorized of which approximately 5,441,960 shares were outstanding, held of
record by approximately 1,500 stockholders.

         The Company has not declared or paid any dividends on its Common Stock.
In accordance with the terms of the Company's loan agreement with its bank,
payment of dividends on Common Stock requires bank approval. The Company does
not expect to recommend the payment of a dividend as it plans to continue to
reinvest profits to expand its business.

         In October 1999, MdBio, Inc., an accredited investor, received 29,153
stock units in connection with its award of $175,000 to the Company under a
manufacturing incentive program that MdBio instituted. Each stock unit consists
of one share of our common stock and a warrant to purchase on additional share
of our common stock at an exercise price of $10.00 per share. MdBio's warrants
expire on September 29, 2003.

         MdBio's warrants were not registered under the Securities Act of 1933,
as amended, in reliance upon the exemptions from registration set forth in
Sections 3(b) and 4(2) of that act, relating to sales by an issuer not involving
any public offering. The MdBio transaction did not involve a public offering.


                                      -21-
<PAGE>

ITEM 6.  SELECTED FINANCIAL DATA

         The statement of income data for each of the fiscal years in the five
year period ended December 31, 1999, and the balance sheet data as of December
31, 1999, 1998, 1997, 1996, and 1995, have been derived from the consolidated
financial statements of the Company. These data should be read in conjunction
with Item 8--Consolidated Financial Statements and Supplementary Data, and Item
7--Management's Discussion and Analysis of Financial Condition and Results of
Operations appearing elsewhere herein.

<TABLE>
<CAPTION>
                                                                                      Year Ended December 31,
                                                                  -----------------------------------------------------------------
                                                                    1999       1998(1)        1997(2)         1996           1995
                                                                  --------    --------       --------       --------       --------
Consolidated Statement of Income Data:                                        (In thousands, except per share data)
<S>                                                               <C>         <C>            <C>            <C>            <C>
REVENUE:
  Products                                                        $ 14,057    $ 13,075       $ 11,711       $  8,470       $  6,622
  Services                                                          15,214      13,006         10,588          7,039          5,649
                                                                  --------    --------       --------       --------       --------
    Total revenue                                                   29,271      26,081         22,299         15,509         12,271
                                                                  --------    --------       --------       --------       --------

COSTS AND EXPENSES:
  Cost of products                                                   7,267       7,180          5,773          4,252          3,564
  Cost of services                                                  11,168       8,897          7,239          4,856          4,168
  Research and development                                           3,259       2,461          1,311            797            375
  Acquired research and development (3)                                 --       4,231             --             --             --
  Selling and marketing                                              4,024       3,939          3,241          2,188          1,340
  General and administrative                                         4,442       4,275          3,343          2,401          2,316
                                                                  --------    --------       --------       --------       --------
    Total operating costs and expenses                              30,160      30,983         20,907         14,494         11,763
                                                                  --------    --------       --------       --------       --------
    (Loss) income from operations                                     (889)     (4,902)         1,392          1,015            508
Interest (expense) income, net                                        (424)        (51)           283           (213)          (336)
                                                                  --------    --------       --------       --------       --------
    (Loss) income before income taxes and extraordinary item        (1,313)     (4,953)         1,675            802            172
Benefit from (provision for) income taxes                              499         564           (670)          (321)           (69)
                                                                  --------    --------       --------       --------       --------
    Net (loss) income                                             $   (814)   $ (4,389)      $  1,005       $    481       $    103
                                                                  --------    --------       --------       --------       --------
Net (loss) income per share, basic                                $  (0.17)   $  (0.94)      $   0.23       $   0.17       $   0.04
Net (loss) income per share, diluted                              $  (0.17)   $  (0.94)      $   0.21       $   0.14       $   0.03

Number of shares used to calculate net income per share
  Basic                                                              4,670       4,655          4,438          2,916          2,570
  Diluted                                                            4,670       4,655          4,780          3,340          3,040

<CAPTION>
                                                                                          December 31,
                                                                  -----------------------------------------------------------------
                                                                    1999        1998           1997           1996           1995
                                                                  --------    --------       --------       --------       --------
Consolidated Balance Sheet Data:                                              (In thousands, except per share data)
<S>                                                               <C>         <C>            <C>            <C>            <C>

Working capital                                                   $ 10,053    $  9,095       $  9,633       $ 12,836       $  4,688
Total assets                                                        26,162      24,082         23,650         19,798          9,928
Long term debt, less current maturities                              7,146       3,989             26             41          4,216
Total stockholders' equity                                          13,646      14,069         18,067         16,290          3,187
Dividends                                                               --          --             --             --             --
</TABLE>

(1) Effective September 30, 1998, the Company acquired all classes of stock of
    BioSeq, Inc., a development stage company with no revenue, for a total
    purchase price of $4,226,000.
(2) Effective July 1, 1997, the Company acquired the business and net assets of
    Source Scientific, Inc. for $1,994,000 which increased 1997 revenue by
    $2,608,000.
(3) Consists of $3,381,000 of in-process research and development related to the
    BioSeq acquisition, and a charge of $850,000 related to the purchase of
    license technology in the first quarter of 1998.


                                      -22-

<PAGE>



ITEM 7.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL
               CONDITION AND RESULTS OF OPERATIONS.

OVERVIEW

         The Company generates revenue from products and services provided
primarily to the IN VITRO diagnostic infectious disease industry. As discussed
in Note 6 to the Consolidated Financial Statements, the Company has five
operating segments: "Diagnostics," "BBI Biotech," "Clinical Laboratory
Services," "Laboratory Instrumentation" and "Other.". Two of these,
"Diagnostics" and "Laboratory Instrumentation" manufacture products, although
the Laboratory Instrumentation segment also generates service revenue. Within
Diagnostics there are three groups: Quality Control Panels, Accurun(R) Run
Controls, and Diagnostic Components. The remaining three segments generate
service revenue and consist of "BBI Biotech", "Clinical Laboratory Services",
and "Other" (Two development stage operations focused on research and
development). Within BBI Biotech there are three groups: Contract Research,
Blood Processing and Repository Services, and research services. Revenue in the
"Other" segment consists of both private and NIH funded support for the research
activities associated with our pressure cycling technology and drug discovery
operations. See Note 6 for a further discussion of the activities of these
segments.

PRODUCTS

         The economics and cost structures of the segments have certain
differences. The Diagnostics segment has historically been the largest and most
profitable segment, both in whole dollars and in operating profit margin, as it
operates primarily in a commercial environment with fewer competitors and
relatively short product development cycles. The Laboratory Instrumentation
segment has been in decline for several years prior to its acquisition in mid
1997, and management is working to turn around this business. It also operates
in a highly competitive, low margin business: contract manufacturing of
instruments and devices. At the current low sales level of less than $3 million
in revenue, it operates significantly under capacity with high overhead, and
should significantly benefit from relatively small revenue increases.

SERVICES

         BBI Biotech has been project oriented with a high proportion of its
revenue generated from government contracts (for both research and service
activities) and assisting the other segments in their new product and service
development. It has the highest level of inter-segment activity, and is
structured around project tracking of direct costs plus overhead and a low
percentage fee. Its financial goal has been to breakeven while contributing to
the development of future products and services for the Company. The Clinical
Laboratory Services segment offers specialty infectious disease testing for
hospital, doctors, blood banks and other reference laboratories on a fee per
test basis. It operates in a segment of the healthcare field that continues to
experience cost containment pressures, and has many competitors. The combination
has resulted in operating margin pressures. The "Other" segment's two R&D
operations do not currently have any product or service revenue, and none is
expected in the near future. Their revenue to date consists of both private and
public (NIH) funding of segment research. Most of the expenditures by this
segment are for R&D expenses, and general management expenses including patent
costs. The Company continues to seek funding from both


                                     -23-



<PAGE>



private and public sources to minimize the impact of their development costs
on the Company's overall operating results.

QUARTERLY FLUCTUATIONS

         Historically, the Company's results of operations have been subject to
quarterly fluctuations due to a variety of factors, primarily customer
purchasing patterns, driven by end-of-year expenditures, and seasonal demand
during the summer months for certain laboratory testing services. In particular,
in the Diagnostics segment, the Company's sales of its off-the-shelf Quality
Control Products and Diagnostic Components typically have been highest in the
fourth quarter and lowest in the first quarter of each fiscal year, whereas OEM
product sales may peak in any quarter of the year, depending on the production
cycle of a given project. Clinical Laboratory testing services have generally
reached a seasonal peak during the third quarter, coinciding with the peak
incidence of Lyme Disease. In the Company's BBI Biotech segment, research
contracts are generally for large dollar amounts spread over one to five year
periods, and upon completion, frequently do not have renewal phases. As a result
these contracts can cause large fluctuations in revenue and net income. In
addition to staff dedicated to internal research and development, certain of the
Company's technical staff work on both contract research for customers and
Company sponsored research and development. The allocation of certain technical
staff to such projects depends on the volume of Contract Research. As a result,
research and development expenditures fluctuate due to increases or decreases in
contract research performed. Neither the Laboratory Instrumentation segment nor
the Other segment are subject to material seasonal variations.

RESEARCH AND DEVELOPMENT

         With the acquisition of BioSeq, Inc and its pressure cycling technology
in September 1998 as well as the hiring of a Vice President for the Drug
Discovery and Development program and its subsequent formation of a new
subsidiary ("Panacos Pharmaceuticals, Inc."), the Company has significantly
increased its rate of research and development spending on new technologies in
the Other operating segment. In addition, it has continued to focus on the
development of new Quality Control Products and new tests for its clinical
laboratory. Additional sales and support will be added as needed with the
expectation of continued future revenue growth.

EXPORT SALES

         The Company does not have any foreign operations. However, the Company
does have significant export sales in Europe, the Pacific Rim countries and
Canada to agents under distribution agreements, as well as directly to test kit
manufacturers. All sales are denominated in US dollars. Export sales for the
years ended December 31, 1999, 1998, and 1997 were $4.0 million, $4.1 million,
and $4.6 million, respectively. The Company expects that export sales will
continue to be a significant source of revenue and gross profit.


                                     -24-



<PAGE>



RESULTS OF OPERATIONS

         The following table sets forth for the periods indicated the percentage
of total revenue represented by certain items reflected in the Company's
consolidated statements of operations:

<TABLE>
<CAPTION>

                                               Year Ended December 31,
                                              -------------------------
                                               1999      1998     1997
                                              ------    ------   ------
<S>                                           <C>       <C>      <C>
Revenue:
 Products                                       48.0%     50.1%    52.5%
 Services                                       52.0      49.9     47.5
                                              ------    ------   ------
   Total revenue                               100.0     100.0    100.0
Gross profit                                    37.0      38.4     41.6
Operating expenses:
 Research and Development                       11.1       9.4      5.9
 Acquired research and development                -       16.2       -
 Selling and marketing                          13.7      15.1     14.5
 General and administrative                     15.2      16.4     15.0
                                              ------    ------   ------
   Total operating expenses                     40.0      57.1     35.4
                                              ------    ------   ------
 (Loss) income from operations                  (3.0)    (18.8)     6.2
Interest income (expense)                       (1.5)     (0.2)     1.3
                                              ------    ------   ------
(Loss) income before income taxes               (4.5)    (19.0)     7.5
Net (loss) income                               (2.8)    (16.8)     4.5
                                              ======    ======   ======
Product gross profit                            48.3%     45.1%    50.7%
Services gross profit                           26.6%     31.6%    31.6%

</TABLE>

YEARS ENDED DECEMBER 31, 1999 AND 1998

REVENUE

Total revenue increased 12.2%, or $3,190,000, to $29,271,000 in 1999 from
$26,081,000 in 1998. The increase in revenue was the result of an increase in
product revenue of 7.5% or $982,000 to $14,057,000 from $13,075,000, and an
increase in service revenue of 17.0% or $2,208,000 to $15,214,000 from
$13,006,000 in 1998.

         PRODUCT REVENUE. The product revenue increase was primarily
attributable to a $700,000 increase by the Diagnostics segment and a $287,000
increase by the Laboratory Instrumentation segment. The Diagnostics increase was
a result of a 15.0% increase in Accurun(R) sales as the Company continued to
successfully penetrate the emerging end-user market, and a 57.8% increase in
Basematrix sales due to increased outsourcing occurring in the IN VITRO
diagnostics industry. These increases were partially offset by a 22.7% decrease
in Seroconversion Panel sales, as the consolidation within the IN VITRO
diagnostic industry has negatively affected demand for these products. The
Laboratory Instrumentation segment achieved a $287,000 or 12.6% increase in
instrument sales as it refocused its efforts in OEM contract manufacturing.
Management feels that the end-user market will continue to be an area of growth
for its Quality Control Products while the outsourcing within the IN VITRO
diagnostics market will continue to benefit sales of Diagnostic Components and
Laboratory Instrumentation.


                                     -25-



<PAGE>



         SERVICE REVENUE. The increase in service revenue was primarily
attributable to a $942,000 increase in BBI Biotech, a $2,655,000 increase in
Clinical Laboratory Services, and a $434,000 increase in the Other segment
revenue. Looking at the individual segments, BBI Biotech's growth was driven by
a 43.9% increase in repository services and the start of new contracts in the
AIDS Vaccine Support arena. The Clinical Laboratory Services' growth was led by
a 55.1% increase in molecular testing. And the Other segment's growth was a
result of funding received from both the NIH and the Consortium for Plasma
Science, which partially defrayed the cost of pressure cycling technology
development. These increases were partially offset by a $1,293,000 decrease in
Laboratory Instrumentation services as the Company completed its work on the
ABX, Inc., contract in the first quarter of 1999. The Company anticipates that
new contracts at the BBI Biotech segment and molecular testing at the Clinical
Laboratory segment will also contribute to revenue growth.

GROSS PROFIT

         Overall gross profit increased 8.3%, or $831,000, to $10,835,000 in
1999 from $10,004,000 in 1998. Product gross profit increased 15.2%, or
$894,000, to $6,789,000 in 1999 from $5,895,000 in 1998 and product gross margin
increased to 48.3% in 1999, from 45.1% in 1998. Services gross profit decreased
$63,000 to $4,046,000 in 1999 from $4,109,000 in 1998 and service gross margin
declined to 26.6% in 1999 from 31.6% in 1998.

         PRODUCT GROSS MARGIN. The increase in product gross margin was due
entirely to the gross margins realized in the Laboratory Instrumentation
operating segment, which increased from 17.8% in 1998 to 28.1% in 1999 as the
business unit operated at a higher volume, thus realizing better economies of
scale compared with 1998 as overhead costs were spread over a greater number of
units. Product gross margins at the Diagnostics segment remained relatively
steady. Management anticipates that further utilization increases for the
Laboratory Instrumentation segment will continue to benefit gross margins.

         SERVICE GROSS MARGIN. The decrease in service gross margins was
realized at all operating segments. The BBI Biotech segment's service gross
margin decreased from 26.8% to 19.8%. BBI Biotech margins were adversely
affected by startup costs associated with new repository contracts in 1999,
primarily the acquisition of freezers, which under the terms of the contract
become government property and thus are charged directly to cost of sales. Also,
the Clinical Laboratory Services segment realized service gross margins of 30.3%
in 1999 versus 32.4% in 1998. This decrease is due to increased competition in
the molecular testing arena, which created pricing pressure, negatively
affecting margins. Finally, in early 1999 the Laboratory Instruments segment
realized a decrease in service gross margins from 52.7% to 46.3%, as it
completed the high-margin ABX, Inc. contract in early 1999. The Company feels
that service margins will continue to feel pressure from increased competition
in the clinical testing market. Furthermore as BBI Biotech expands its
repository services, low-margin contracts will account for a greater portion of
its total revenue if the Company is not continually successful in obtaining
higher margin commercial services work. The other remaining Company segments do
not generate service revenues that would significantly impact segment results.


                                     -26-



<PAGE>



         RESEARCH AND DEVELOPMENT

         Research and development costs, exclusive of acquired in-process
research and development, increased 32.4% or $797,000 to $3,259,000 in 1999 from
$2,461,000 in 1998. A significant portion of the increase is attributable to the
operating segment referred to as "Other", which consists of the pressure cycling
technology ("PCT") and Drug Discovery activities. The Company increased its PCT
expenditures by approximately $893,000 as it completed the design, development,
and manufacture of 8 prototype PCT instruments known as "barocyclers". The
Company also made significant progress during 1999 with its patents in the
nucleic acid extraction and pathogen inactivation areas. The Company's increased
expenditures in Drug Discovery by approximately $361,000 resulted in expanded
rights under its agreement with the University of North Carolina, at Chapel
Hill, and significant progress in the prosecution of patents for the compounds.
In addition, the BBI Biotech segment increased its spending to continue its
support of the Diagnostics and Clinical Laboratory Services segments.

         There were two accounting charges in 1998, which were classified on the
income statement as acquired in-process research and development. In the first
quarter there was an accounting charge of $850,000 related to the acquisition of
the worldwide exclusive rights to BioSeq, Inc.'s immunodiagnostic research and
development technology. In the third quarter, the Company recorded a charge of
$3,381,000 related to in-process technology as a result of the Company's
acquisition of BioSeq, Inc. This allocation of the purchase price was based on
an independent valuation and was expensed, as no alternative future uses exist.
There were no such charges during 1999.

SELLING AND MARKETING

         Selling and marketing expenditures remained relatively flat during 1999
as compared to 1998, across all operating segments. Costs increased only 2.2% or
$85,000 to $4,024,000 in 1999 from $3,939,000 in 1998 as the Company effectively
managed costs in this area.

GENERAL AND ADMINISTRATIVE

         General and administrative costs increased 3.9% or $166,000 to
$4,442,000 in 1999 from $4,276,000 in 1998. This increase is attributable to the
corporate reorganization that was announced in July of 1999. The reorganization
created operating segments, which are directed by a senior vice president and
general manager. The reorganization resulted in the classification of the
salaries, and other related costs, of two executives in the general and
administrative line of the income statement from other income statement lines,
to more accurately reflect their new responsibilities. General and
administrative costs are expected to increase in 2000, as the reorganization
impact will be felt for the entire fiscal year 2000. In addition, 1999 benefited
as certain general and administrative personnel costs were capitalized as
property and equipment in connection with the implementation of enterprise
resource planning systems at the Diagnostics and Laboratory Instruments
segments.

General and administrative costs at the other segments were flat.

OPERATING LOSS

         As a result of all of the above, the Company experienced an operating
loss of $889,000 versus $4,902,000 in 1998. Excluding the $4,231,000 of acquired
in-process research and development charges realized in 1998, the Company's
operating loss increased by 32.3% or $217,000 to $889,000 in 1999 from $672,000
in 1998. The Diagnostics operating segment realized an increase in operating
income of approximately $225,000 or 40.3%, as a result of ed a a 15% increase in
sales coupled with a relatively steady


                                     -27-



<PAGE>



product gross margin. Clinical Laboratory Services operating segment realized
a significant increase in operating income of approximately $522,000 or
389.6%. as a result of a 37% increase in segment revenues which more than
offset a slight decline in that segment's service gross margin. The
Laboratory Instrumentation segment only realized a slight reduction, 8.1%, in
its operating loss as the improved product gross margin was more than offset
by lower service profitability due to the completion of the previously
discussed ABX contract. These operational improvements were more than offset
by the planned increases in research and development expenditures, which
resulted in significant operating losses in the "Other" operating segment of
$1,345,000. In addition, the BBI Biotech segment also increased its research
and development expenses resulting in a loss of $152,000 in 1999 versus
income of $67,000 in the prior year. Management anticipates continued
strength from its Diagnostics and Clinical Laboratory Services segments.
Although the Laboratory Instrumentation segment has realized operating losses
since it was acquired in July 1997, the Company believes that the goodwill
created in connection with the acquisition is realizable as management
believes that the segment will begin to generate operating income by the end
of 2001. The Company will continue to increase its spending in the Other
segment, however, it expects that the impact from this increased spending on
the Company's bottom line will be mitigated by the planned sale of the common
stock of Panacos and the continued funding support in the area of PCT.

         The Company had net interest expense of $424,000 in 1999 versus $51,000
in 1998. The Company had used its proceeds from its initial public offering and,
at the end of the second quarter of 1998, began to borrow funds from its
revolving line of credit to continue its infrastructure and research and
development investments. In addition to a higher average borrowing balance in
1999, the Company realized the effects of rising interest rates.

         The Company recorded tax benefits at its combined federal and state
statutory rate of 38% for 1999. Although the Company realized consolidated
operating losses for 1999 and 1998 management believes that its valuation
allowance is adequate as the Company plans to return to profitability within six
to twelve months, at which point it will begin to realize benefit from its
federal and state tax assets. The tax benefit rate recognized in 1998 was
adversely affected by the in-process research and development charges discussed
above. The March 1998 technology license transaction resulted in a temporary
difference as the technology license is deductible for tax purposes over a
15-year period, while the September 1998 common stock acquisition resulted in a
permanent difference that is never deductible. See Note 10 to Consolidated
Financial Statements in Item 8 hereunder for further detail.

         The Company had a net loss of $814,000 in 1999 versus $4,389,000 in
1998 as a result of the operating loss, the interest expense, and the effective
tax rate described above.

YEARS ENDED DECEMBER 31, 1998 AND 1997

         In July 1997 the Company acquired the business of Source Scientific,
Inc. The acquisition was completed by a wholly-owned subsidiary of the Company,
BBI Source Scientific, Inc., ("BBI Source") and was accounted for as an asset
purchase. The income statement for 1997 includes the results of BBI Source for
the last six months of the year, effecting comparability of results with 1998.

         Total revenue increased 17.0%, or $3,782,000, to $26,081,000 in 1998
from $22,299,000 in 1997. The increase in revenue was the result of an 11.6%
increase in product revenue of $1,364,000 to $13,075,000 from $11,711,000, and a
22.8% increase in service revenue of


                                     -28-



<PAGE>



$2,418,000 to $13,006,000 from $10,588,000 in 1997. Most of the product
increase was attributable to increased sales of Quality Control Products
achieved by the Diagnostics segment. The increase in such products was led by
Accurun(R) which doubled in sales over the prior year. Also contributing to
the increase in product sales was the inclusion of BBI Source (the Laboratory
Instruments segment) for the full year in 1998 versus a half-year in 1997.
The decrease in Quality Control Panel sales at the Diagnostics segment
partially offset the product sales increases, as sales fell short of
expectations due to consolidation in the IN VITRO diagnostic test kit
industry. The BBI Biotech segment led the increase in service revenue with a
49.8% increase in contract research. Also contributing to the increase in
service revenue was the Clinical Laboratory Testing segment, realizing a
19.5% increase in revenue.

         Overall gross profit increased 7.7%, or $717,000, to $10,004,000 in
1998 from $9,287,000 in 1997. Product gross profit decreased 0.7%, or $43,000,
to $5,895,000 in 1998 from $5,938,000 in 1997 and product gross margin decreased
to 45.1% in 1998 from 50.7%. In 1997 the Diagnostics segment's product gross
margin benefited from significant one-time sale of two "World-Wide Panels,"
which have unusually high gross margins due to their unique characteristics.
These panels sold out in the first quarter of 1998, with minimal impact on 1998.
The remaining product gross margin decrease was the result of lower capacity
utilization at the Laboratory Instrumentation segment. Services gross profit
increased 22.7%, or $759,000, to $4,109,000 in 1998 from $3,350,000 in 1997 and
gross margin remained steady at 31.6% in 1998 and 1997. Higher margins generated
by the Contract Services and Laboratory Instrumentation segments offset the
decrease in margins realized by the increased pricing pressure facing the
Clinical Laboratory Testing segment

         Research and development expenditures increased 87.7%, or $1,150,000,
to $2,461,000 in 1998 from $1,311,000 in 1997. The increase was realized across
all of the segments. The Laboratory Instrumentation segment invested in new
reflectance technology for its Verif-Eye product line. The Diagnostics segments
also increased its development expenditures, specifically for development of
Accurun(R) molecular and immunological Run Controls. The Company invested in
development of new specialized molecular assays for use by the Clinical
Laboratory Testing segment. Finally, the Company began the development of PCT as
it acquired BioSeq, Inc (one component of the Other segment) in September 1998.

         There were two accounting charges during the twelve months ended
December 31, 1998, which were classified on the income statement as acquired
in-process research and development. In the first quarter there was an
accounting charge of $850,000 related to the acquisition of the worldwide
exclusive rights to BioSeq Inc.'s immunodiagnostic research and development
technology. In the third quarter, the Company recorded a charge of $3,381,000
related to in-process technology as a result of the Company's $4,226,000
acquisition of BioSeq, Inc.

         Selling and marketing expenses increased 21.5%, or $698,000, to
$3,939,000 in 1998 from $3,241,000 in 1997. The increase was attributable
primarily to inclusion for a full year in 1998 of the expanded TQS sales,
marketing, and technical support staff added to the Diagnostics segment in the
spring of 1997. The Company also expanded its presence at tradeshows, resulting
in higher expenditures in this category.

         General and administrative costs increased 27.9%, or $933,000, to
$4,276,000 in 1998 from $3,343,000 in 1997. This increase was attributable
primarily to additional support staff, and increased information systems
consulting and investor relations activities at the Diagnostics segment, which
includes the majority of the corporate functions and officers for both periods.
In addition, the inclusion of the Laboratory Instrumentation segment for a full
year added $412,000 of expense to this category.


                                     -29-



<PAGE>



         As a result of all of the above, the Company experienced an operating
loss of $4,902,000 versus income of $1,392,000 in 1997. This decrease was
primarily a result of the acquired in-process research and development expense,
a higher operating loss at the Laboratory Instrumentation segment, increased
research and development expenditures at all segments, and lower profitability
at its Diagnostics and Clinical Laboratory Testing operating segments.

         The Company had net interest expense of $51,000 in 1998 versus interest
income of $283,000 in 1997. The Company had used the proceeds from its initial
public offering and, at the end of the second quarter of 1998, began to borrow
funds from its revolving line of credit to continue its infrastructure and
research and development investments.

         The Company provided taxes at the combined federal and state rate of
38% for 1998 versus 40% in the prior year. The rate decrease was the result of
offsetting the Massachusetts taxable income of the Diagnostics operating segment
with the Massachusetts losses of BBI BioSeq, Inc., This benefit was adversely
impacted by the tax treatment of the acquired in-process technology from BioSeq,
Inc. as the acquisition was structured as a stock purchase. Therefore, the
effective benefit rate for 1998 was approximately 11%.

         The Company had a net loss of $4,389,000 in 1998 versus net income of
$1,005,000 in 1997 as a result of the operating loss described above and a shift
to interest expense in 1998 versus interest income in 1997.


                                     -30-



<PAGE>



LIQUIDITY AND CAPITAL RESOURCES

         At December 31, 1999, the Company had cash and cash equivalents of
approximately $315,000 and working capital of $10,053,000. Gross trade accounts
receivable increased $483,000 or 7.2% as a result of a 7.8% increase in revenues
in the fourth quarter of 1999 versus the same period in 1998. Inventory
increased $228,000 or 3.4%, related primarily to work-in-process for upcoming
projects within the Diagnostics segment.

         The Company has financed its operations to date through cash flow from
operations, borrowings from banks and the sale of its common stock. The Company
expects its cash flow, working capital, and available borrowings under its
revolving line of credit to meet existing operational needs in 2000. In mid 1999
the Company and its bank agreed to a modified borrowing agreement with revised
financial covenants, which the Company expects will meet existing operational
needs for the foreseeable future. At December 31, 1999 the Company was in
compliance with its financial covenants.

         In addition, in March 2000 the Company received a signed term sheet
from a bank for a mortgage of the Company's West Bridgewater, MA facility. The
Company anticipates that it will complete the transaction in the beginning of
the second quarter of 2000. The Company intends to use the $2,500,000 of cash
generated to pay down its existing line of credit.

         Net cash used in operations for 1999 was $657,000 as compared to
$1,215,000 in 1998. This decrease in operational use of cash is due to improved
management of working capital, including better utilization of inventory and
more effective management of payables and receivables. The $123,000 increase in
reserve for doubtful accounts partially offset this improvement of operational
cash flow. The Company increased its reserve because there has been a gradual
shift in the Company's customer mix from large, well known, IN VITRO diagnostics
manufacturers to a more diversified customer matrix, which includes smaller,
less established companies. While the Company has not yet experienced a
significant increase in write-off's as a result of this shift, management feels
that establishing the current level of reserve is prudent.

         Cash used in investing activities for 1999, 1998 and 1997 amounted to
$2,731,000, $5,462,000, and $5,396,000, respectively. Substantially all of the
investing activities in 1999 related to additions of property and equipment.
These expenditures included approximately $1,138,000 of computer hardware and
software, including approximately $807,000 invested in new enterprise resource
planning systems for the Diagnostics and Laboratory Instrumentation segments.
The BBI Biotech segment spent approximately $522,000 on leasehold improvements
as it prepared a new facility in Frederick, Maryland for the repository contract
with the National Institute of Allergy and Infectious Disease, Division of AIDS.
In addition, the Company continued construction at its BBI Diagnostics facility
in West Bridgewater, Massachusetts as it spent approximately $352,000 improving
this manufacturing facility. In 1998, three major items accounted for most of
the Company's investing activities. First, effective September 30, 1998, the
Company completed the acquisition of the remaining common stock of BioSeq, Inc.,
for a cash expenditure of $2,557,000. Second, $1,460,000 was expended for
additional improvements at the Company's Massachusetts and Maryland facilities.
Finally, $437,000 was spent on software, hardware and implementation costs for
the enterprise resource planning system. In 1997, four items accounted for most
of the investing activities. First, the Company exercised its option to purchase
an additional 165,000 shares of BioSeq, Inc. stock at an aggregate cost of
$750,000, thereby increasing its ownership of BioSeq to 19.9%. Second, in May
1997, the Company's BBI Biotech subsidiary signed a ten year lease for new
laboratory space in Gaithersburg, Maryland and spent $566,000 on leasehold
improvements for new laboratory space for its contract research and product
development activities. Third, the expansion and renovation of its BBI
Diagnostics manufacturing facility in West Bridgewater, Massachusetts, commenced


                                     -31-



<PAGE>



construction and approximately $920,000 was expended. Finally, the Company
completed the acquisition of Source Scientific, Inc. at a purchase price of
$1,994,000 including acquisition costs.

         During 1999, net cash provided by financing activities was
approximately $3,555,000 from a combination of net borrowings of $3,164,000
under the revolving line of credit, and proceeds of $206,000 from the sale of
stock and stock warrants to third party investors. In addition, the Company
realized proceeds of $148,000 and $37,000 from the sale of stock and the
exercise of stock options, respectively. During 1998, net cash provided by
financing activities was $4,052,000 from a combination of net borrowings of
$3,963,000 under the revolving line of credit, and proceeds of $89,000 from the
exercise of stock options. During 1997, net cash generated from financing
activities included $300,000 from the exercise of warrants, and $182,000 from
exercising stock options. Also in 1997, $1,124,000 was used to pay down debt
acquired in connection with the Source acquisition.

         The Company anticipates significant capital expenditures in 2000 to
continue as it plans to compete renovations to its manufacturing facility in
Massachusetts and its repository facility in Frederick, Maryland. In addition to
the renovations, the Company intends to continue its enterprise resource
planning system implementation, as it installs new systems at BBICL and BBI
Biotech. The Company believes that existing cash balances, the borrowing
capacity available under the revolving line of credit, cash generated from
operations and proceeds from the issuance of its common stock are sufficient to
fund operations and anticipated capital expenditures in 2000. Except for
purchase orders in connection with the manufacturing expansion, there were no
material financial commitments for capital expenditures as of December 31, 1999.

         In February of 2000, the Company received notice that certain warrant
holders exercised 500,000 warrants. This exercise will result in proceeds to the
Company of approximately $2,100,000, net of transaction costs, when the
transaction closes, pursuant to completing the registration of the underlying
shares.

YEAR 2000 READINESS DISCLOSURE

         Our Year 2000 ("Y2K") program was designed to minimize the possibility
of serious Year 2000 interruption. In 1997 the Company decided to significantly
upgrade its "business system" (all computer hardware and software used to run
its business including its operations management, administration and financial
systems).

          Specifications were developed for desired capabilities, including Year
2000 compliance and the Company began to assess various enterprise resource
planning systems ("ERP System") in 1998. Additionally, the Company organized a
task force at each operating segment to review other infrastructure areas
including communications systems, building security systems and embedded
technologies in areas such as laboratory instruments and manufacturing
equipment. The Company also began to survey mayor suppliers, distributors, and
customers to determine the status and schedule for their Year 2000 compliance.

         During the fourth quarter of 1999 the Company completed the ERP
implementation at the two of the Company's subsidiaries. The other subsidiaries
received upgraded, Year 2000 compliant versions of existing software. The
Company spent less than $200,000 to prepare for Y2K. This amount includes the
cost to upgrade existing software packages to compliant versions, use of
existing resources to execute surveys and measure results, and incremental costs
associated with other infrastructure areas. This amount excludes all costs
associated with the implementation of the ERP Systems which was completed for
reasons beyond Y2K compliance.

         Possible Year 2000 worst case scenarios include the interruption of
significant parts of our business as a result of internal business system
failure or the failure of the business systems of the Company's suppliers,
distributors or customers. Any such interruption may have a material adverse
impact on our future results. Although no significant problems have been noted
to date, the Company acknowledges that there is still risk that such problems
may occur. Any such interruption could have a material adverse impact on the
future results of the Company.

Recent Accounting Pronouncements

         Statement of Financial Accounting Standards No. 133, "Accounting for
Derivative Instruments and Hedging Activities" (SFAS 133) is effective, as
amended for quarters of fiscal years beginning after June 15, 2000. The new
standard requires companies to record derivatives on the balance sheet as assets
or liabilities, measured at fair value. Gains or losses resulting from changes
in the values of those derivatives would be accounted for depending on the use
of the derivatives and whether they qualify for hedge accounting. The key
criterion for hedge accounting is that the hedging relationship must be highly
effective in achieving offsetting changes in fair value or cash flows. The
Company does not currently engage in derivative trading or hedging activity.


                                     -32-



<PAGE>

         In December 1999, the Staff of the Securities and Exchange Commission
issued Staff Accounting Bulletin No. 101, "Revenue Recognition in Financial
Statements" ("SAB 101"). This SAB summarizes certain of the Staff's views in
applying generally accepted accounting principles, in the United States, to
revenue recognition in financial statements. SAB 101 is effective for the
Company's quarter ended June 30, 2000. The Company does not expect the
provisions of SAB 101 to have a material impact on its financial statements.

Forward - Looking Information

         The Annual Report on Form 10-K contains forward-looking statements
concerning the Company's financial performance and business operations. The
Company wishes to caution readers of this Annual Report on Form 10-K that actual
results might differ materially from those projected in the forward-looking
statements contained herein.

         Factors which might cause actual results to differ materially from
those projected in the forward-looking statements contained herein include the
following: finalization of SEC guidelines for valuation of in-process research
and development as it relates to purchase accounting; inability of the Company
to develop the end-user market for quality control products; inability of the
Company to integrate the business of Source Scientific, Inc. into the Company's
business; inability of the Company to grow the sales of Source Scientific, Inc.
to the extent anticipated; the renewal and full funding of contracts with
National Institutes of Health (NIH), National Heart, Lung and Blood Institute
(NHLBI) and other government agencies; the inability of the Company to develop
the technology recently acquired as part of its purchase of BioSeq, Inc. to the
level of commercial utilization; the inability of Panacos to obtain sufficient
funding to progress to more advanced stages of development, the failure of
Panacos to identify and successfully commercialize any new drugs or vaccines,
the inability of the Company to obtain an adequate supply of the unique and rare
specimens of plasma and serum necessary for certain of its products; significant
reductions in purchases by any of the Company's major customers; the
interruption of significant parts of the Company's business as a result of
internal business system failure or the failure of the business systems of its
suppliers, distributors or customers due to the inability of such systems to
properly interpret dates subsequent to December 31, 1999; and the potential
insufficiency of Company resources, including human resources, plant and
equipment and management systems, to accommodate any future growth. Certain of
these and other factors which might cause actual results to differ materially
from those projected are more fully set forth under the caption "Risk Factors"
in the Company's Registration Statement on Form S-1 (SEC File No. 333-10759).

ITEM 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

         The Company is subject to interest rate risk in connection with its
long-term debt. The aggregate hypothetical loss in earnings for one year of
those financial instruments held by the Company at December 31, 1999 that are
subject to interest rate risk resulting from a hypothetical increase in interest
rates of 10 percent is less than $100,000, after-tax. The hypothetical loss was
determined by calculating the aggregate impact of a 10 percent increase in the
interest rate of each variable rate financial instrument held by the Company at
December 31, 1999, that is subject to interest rate risk. Fixed rate financial
instruments were not evaluated, as the Company believes the risk exposure is not
material.

         The Company is exposed to concentrations of credit risk in cash and
cash equivalents and trade receivables. Cash and cash equivalents are placed
with major financial institutions with high quality credit ratings. Trade
receivables credit risk exposure is significant as the Company derives a
significant portion of its revenues from a small number of customers however
this risk is mitigated by the dispersion across different industries and
geographies in which the customers operate; in addition to this, the largest
customer (approximately 15% of 1999 consolidated revenue) was the NIH, a U.S.
Government agency. The Company is exposed to credit-related risks associated
with its trade accounts receivable denominated in U.S. Dollars but receivable
from foreign customers.


                                      -33-

<PAGE>

ITEM 8.            FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

                     BOSTON BIOMEDICA, INC. AND SUBSIDIARIES

                           CONSOLIDATED BALANCE SHEETS

<TABLE>
<CAPTION>
                                                                              December 31,
                                                                    --------------------------------
                                                                       1999                 1998
                                                                    -----------          -----------
<S>                                                                 <C>                  <C>
                           ASSETS

CURRENT ASSETS:
  Cash and cash equivalents                                         $   314,923          $   146,978
  Accounts receivable, less allowances of $746,797 in 1999 and
    $623,710 in 1998                                                  6,446,318            6,086,693
  Inventories                                                         6,917,916            6,689,768
  Prepaid expenses                                                      344,353              479,983
  Deferred income taxes                                                 934,790              847,268
                                                                    -----------          -----------
      Total current assets                                           14,958,300           14,250,690
                                                                    -----------          -----------

Property and equipment, net                                           8,295,024            6,925,423

OTHER ASSETS:
  Goodwill and other intangibles, net                                 2,589,310            2,809,825
  Deferred income taxes                                                 220,535                   --
  Notes receivable and other                                             99,171               96,447
                                                                    -----------          -----------
                                                                      2,909,016            2,906,272
                                                                    -----------          -----------
      TOTAL ASSETS                                                  $26,162,340          $24,082,385
                                                                    ===========          ===========

             LIABILITIES AND STOCKHOLDERS' EQUITY

CURRENT LIABILITIES:
  Accounts payable                                                 $  2,552,268         $  2,369,495
  Accrued compensation                                                1,189,140            1,284,162
  Accrued income taxes                                                  112,487                   --
  Other accrued expenses                                              1,028,667              795,642
  Current maturities of long term debt                                   22,414               15,569
  Deferred revenue                                                           --              690,760
                                                                    -----------          -----------
      Total current liabilities                                       4,904,976            5,155,628
                                                                    -----------          -----------

LONG-TERM LIABILITIES:
  Long term debt, less current maturities                             7,145,651            3,988,602
  Other liabilities                                                     465,590              730,138
  Deferred income taxes                                                      --              139,363

COMMITMENTS AND CONTINGENCIES

STOCKHOLDERS' EQUITY:
  Common stock, $.01 par value; authorized 20,000,000 shares in
    1999 and 1998; issued and outstanding 4,773,365 in 1999 and
    4,667,816 in 1998                                                    47,734               46,679
  Additional paid-in capital                                         16,809,242           16,418,716
  Accumulated deficit                                                (3,210,853)          (2,396,741)
                                                                    -----------          -----------
      Total stockholders' equity                                     13,646,123           14,068,654
                                                                    -----------          -----------
    TOTAL LIABILITIES & STOCKHOLDERS' EQUITY                       $ 26,162,340         $ 24,082,385
                                                                    ===========          ===========
</TABLE>

                 The accompanying notes are an integral part of
                    these consolidated financial statements


                                      -34-
<PAGE>

                     BOSTON BIOMEDICA, INC. AND SUBSIDIARIES

                        CONSOLIDATED STATEMENTS OF INCOME

<TABLE>
<CAPTION>
                                                                               Years Ended December 31,
                                                                    --------------------------------------------------
                                                                        1999               1998               1997
                                                                    ------------       ------------       ------------
<S>                                                                 <C>                <C>                <C>
REVENUE:
  Products                                                          $ 14,056,657       $ 13,075,085       $ 11,711,026
  Services                                                            15,214,431         13,005,991         10,588,311
                                                                    ------------       ------------       ------------
    Total revenue                                                     29,271,088         26,081,076         22,299,337

COSTS AND EXPENSES:
  Cost of products                                                     7,267,273          7,179,920          5,773,417
  Cost of services                                                    11,168,595          8,897,046          7,238,527
  Research and development                                             3,258,542          2,461,316          1,311,190
  Acquired research and development                                           --          4,230,812                 --
  Selling and marketing                                                4,023,791          3,938,753          3,241,422
  General and administrative                                           4,441,524          4,275,627          3,342,829
                                                                    ------------       ------------       ------------
    Total operating costs and expenses                                30,159,725         30,983,474         20,907,385

    (Loss) income from operations                                       (888,637)        (4,902,398)         1,391,952

Interest income                                                            6,146             27,901            295,998
Interest expense                                                        (430,593)           (78,621)           (13,227)
                                                                    ------------       ------------       ------------

    (Loss) income before income taxes                                 (1,313,084)        (4,953,118)         1,674,723

Benefit from (provision for) income taxes                                498,972            564,399           (669,889)
                                                                    ------------       ------------       ------------

    Net (loss) income                                               $   (814,112)      $ (4,388,719)      $  1,004,834
                                                                    ============       ============       ============

    Net (loss) income per share, basic                              $      (0.17)      $      (0.94)      $       0.23
    Net (loss) income per share, diluted                            $      (0.17)      $      (0.94)      $       0.21

Number of shares used to calculate net (loss) income per share
    Basic                                                              4,669,717          4,654,609          4,437,801
    Diluted                                                            4,669,717          4,654,609          4,780,070
</TABLE>

                 The accompanying notes are an integral part of
                    these consolidated financial statements


                                      -35-
<PAGE>

                     BOSTON BIOMEDICA, INC. AND SUBSIDIARIES
           CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY

              FOR THE YEARS ENDED DECEMBER 31, 1999, 1998 AND 1997

<TABLE>
<CAPTION>
                                                                Common Stock
                                                           ------------------------    Additional      Retained       Total
                                                                          $.01 Par       Paid-In       Earnings    Stockholders'
                                                              Shares        Value        Capital       (Deficit)      Equity
                                                           ----------   -----------    -----------   -----------    -----------
<S>                                                         <C>         <C>            <C>           <C>            <C>
BALANCE, December 31, 1996                                  4,378,157   $    43,782    $15,258,656   $   987,144    $16,289,582
  Stock options and warrants exercised                        244,409         2,444        480,032                      482,476
  Tax benefit of stock options exercised                                                   290,361                      290,361
  Net income                                                                                           1,004,834      1,004,834
                                                           ----------   -----------    -----------   -----------    -----------
BALANCE, December 31, 1997                                  4,622,566        46,226     16,029,049     1,991,978     18,067,253
  Stock options and warrants issued with acquisition                                       236,327                      236,327
  Stock options exercised                                      45,250           453         88,696                       89,149
  Tax benefit of stock options exercised                                                    64,644                       64,644
  Net loss                                                                                            (4,388,719)    (4,388,719)
                                                           ----------   -----------    -----------   -----------    -----------
BALANCE, December 31, 1998                                  4,667,816        46,679     16,418,716    (2,396,741)    14,068,654
  Common stock issued                                          53,300           533        147,905                      148,438
  Stock warrants issued, net of issuance costs                                             206,011                      206,011
  Stock options and warrants exercised                         52,249           522         36,610                       37,132
  Net loss                                                                                              (814,112)      (814,112)
                                                           ----------   -----------    -----------   -----------    -----------
BALANCE, December 31, 1999                                  4,773,365   $    47,734    $16,809,242   $(3,210,853)   $13,646,123
                                                           ==========   ===========    ===========   ===========    ===========
</TABLE>

                 The accompanying notes are an integral part of
                    these consolidated financial statements


                                      -36-
<PAGE>

                     BOSTON BIOMEDICA, INC. AND SUBSIDIARIES

                      CONSOLIDATED STATEMENTS OF CASH FLOWS

<TABLE>
<CAPTION>
                                                                            Years Ended December 31,
                                                                 -----------------------------------------------
                                                                    1999              1998              1997
                                                                 -----------       -----------       -----------
<S>                                                              <C>               <C>               <C>
CASH FLOWS FROM OPERATING ACTIVITIES:
  Net (loss) income                                              $  (814,112)      $(4,388,719)      $ 1,004,834
  Adjustments to reconcile net (loss) income to net
    cash (used in) provided by operating activities:
  Depreciation and amortization                                    1,578,731         1,280,049           858,434
  Provision for doubtful accounts                                     96,661           154,335           174,925
  Deferred rent and other                                           (264,549)          117,911           (71,381)
  Deferred income taxes                                             (447,420)         (528,676)            2,391
  Tax benefit of stock options exercised                                  --            64,644           290,361
  Acquired research and development                                       --         4,230,812                --
Changes in operating assets and liabilities:
  Accounts receivable                                               (456,286)         (675,171)       (1,907,413)
  Other assets                                                            --                --           (13,930)
  Inventories                                                       (228,148)         (786,947)         (640,301)
  Prepaid expenses and other                                         135,630          (144,199)            2,546
  Accounts payable                                                   182,773           105,122           797,690
  Accrued compensation and other expenses                            250,490           (86,054)         (102,199)
  Deferred revenue                                                  (690,760)         (558,264)          330,855
                                                                 -----------       -----------       -----------
    Net cash (used in) provided by operating activities             (656,990)       (1,215,157)          726,812
                                                                 -----------       -----------       -----------

CASH FLOWS FOR INVESTING ACTIVITIES:
  Acquired research and development                                       --          (850,000)               --
  Payments for additions to property and equipment                (2,727,816)       (2,929,568)       (2,612,697)
  Purchase of intangible assets                                           --            (3,470)          (39,625)
  Return of deposits and other                                        (2,724)           27,731                --
  Purchase of long term investment                                        --                --          (750,000)
  Acquisitions, net of cash aquired                                       --        (1,706,540)       (1,993,722)
                                                                 -----------       -----------       -----------
    Net cash used in investing activities                         (2,730,540)       (5,461,847)       (5,396,044)
                                                                 -----------       -----------       -----------

CASH FLOWS FROM FINANCING ACTIVITIES:
  Proceeds from issuance of debt                                   3,175,427         3,977,351                --
  Repayments of long-term debt                                       (11,533)          (14,878)       (1,123,526)
  Proceeds from issuance of common stock and stock warrants          391,581            89,149           482,476
                                                                 -----------       -----------       -----------
    Net cash provided by (used in) financing activities            3,555,475         4,051,622          (641,050)
                                                                 -----------       -----------       -----------

(DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS:                    167,945        (2,625,382)       (5,310,282)
  Cash and cash equivalents, beginning of year                       146,978         2,772,360         8,082,642
                                                                 -----------       -----------       -----------
  Cash and cash equivalents, end of year                         $   314,923       $   146,978       $ 2,772,360
                                                                 ===========       ===========       ===========

SUPPLEMENTAL INFORMATION:
  Income taxes paid                                              $    33,391       $   113,287       $   662,304
  Interest paid                                                  $   414,297       $    72,755       $     5,731
  Long-term investment included in acquisition                                     $ 1,482,500
</TABLE>

                 The accompanying notes are an integral part of
                    these consolidated financial statements


                                      -37-
<PAGE>

                     BOSTON BIOMEDICA, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(1)      Business and Significant Accounting Policies

         Boston Biomedica, Inc. ("BBI") and Subsidiaries (together, the
"Company") provide infectious disease diagnostic products, laboratory
instrumentation, contract research and specialty infectious disease testing
services to the in-vitro diagnostic industry, government agencies, blood banks,
hospitals and other health care providers worldwide. The Company also invests in
new technologies related to infectious diseases. The Company is subject to risks
common to companies in the biotechnology, medical device and diagnostic
industries, including but not limited to, development by the Company or its
competitors of new technological innovations, dependence on key personnel,
protection of proprietary technology, and compliance with governmental
regulations.

         Significant accounting policies followed in the preparation of these
consolidated financial statements are as follows:

  (i) Principles of Consolidation

         The consolidated financial statements include the accounts of BBI and
its wholly-owned subsidiaries, BBI Biotech Research Laboratories, Inc. ("BBI
Biotech"), BBI Clinical Laboratories, Inc. ("BBICL"), BBI Source Scientific,
Inc. ("BBI Source"), and BBI BioSeq, Inc. ("BBI BioSeq"). BBI consists primarily
of the Diagnostic Products segment as well as executive corporate officers.
During the year, the Company incorporated Panacos Pharmaceuticals, Inc.,
("Panacos"). Effective January 2000, Panacos will be accounted for as an
additional consolidated subsidiary of the Company. All significant intercompany
accounts and transactions have been eliminated in the consolidation. Certain
amounts included in the prior year's financial statements may have been
reclassified to conform to the current presentation.

  (ii) Use of Estimates

         To prepare the financial statements in conformity with generally
accepted accounting principles, management is required to make significant
estimates and assumptions that affect the reported amounts of assets and
liabilities and disclosure of contingent assets and liabilities at the date of
the financial statements and the reported amounts of revenues and expenses
during the reporting period. In particular, the Company records reserves for
estimates regarding the collectability of accounts receivable, the value and
realizability of intangible assets, as well as the net realizable value of its
inventory.

         The valuation methodology applied to the acquisition of BioSeq, Inc.
(see Note 2) was based on estimated discounted future cash flows. The purchase
price accounting is based on this valuation. Significant assumptions include
gross and operating profit margins, and future tax, discount, and royalty rates.

         Actual results could differ from the estimates and assumptions used by
management.

  (iii) Revenue Recognition

         Product revenue is recognized upon shipment of the products or, for
specific orders at the request of the customer, on a bill and hold basis after
completion of manufacture. All bill and hold transactions meet specified revenue
recognition criteria which include normal billing, credit and payment terms,
firm commitment and transfer to the customers of all risks and rewards of
ownership. Total revenue related to bill and hold transactions was approximately
$1,998,000, $1,388,000, and $459,000 for the years ended December 31, 1999,
1998, and 1997, respectively.

         Services are recognized as revenue upon completion of tests for
specialty laboratory services. Revenue from service contracts and research and
development contracts for the Company's laboratory instrumentation business is
recognized as the service and research and development activities are performed
under the terms of the contracts.

         Revenue under long-term contracts, generally lasting from one to five
years, including funded research and development contracts, is recorded when
costs to perform such research and development activities are incurred. Billing
under long-term contracts are generally at cost plus a predetermined profit.
Billing occurs as costs associated with time and materials are incurred.
Customers are obligated to pay for such services, when billed, and payments are
non-refundable. On occasion certain customers make advance payments that are
deferred until revenue recognition is appropriate. The Company does not believe
there are any material collectability issues associated with these receivables.


                                      -38-
<PAGE>

                     BOSTON BIOMEDICA, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(1)  Business and Significant Accounting Policies (Continued)

         Total revenue related to long-term contracts was approximately
$4,457,000, $4,175,000, and $3,125,000 for the years ended December 31, 1999,
1998 and 1997, respectively. Total contract costs associated with these
agreements were approximately $4,323,000, $3,950,000, and $2,782,000 for the
years ended December 1999, 1998 and 1997, respectively. Included in the revenue
recognized under long-term contracts are certain unbilled receivables
representing additional indirect costs, which are allowed under the terms of the
respective contracts. Unbilled receivables were less than $40,000 for all years
presented.

  (iv) Cash and cash equivalents

         The Company's policy is to invest available cash in short-term,
investment grade, interest bearing obligations, including money market funds,
municipal notes, and bank and corporate debt instruments. Securities purchased
with initial maturities of three months or less are valued at cost plus accrued
interest, which approximates fair market value, and classified as cash
equivalents.

  (v) Research and Development Costs

         Research and development costs are expensed as incurred.

  (vi) Inventories

         Inventories are stated at the lower of cost or net realizable value and
include material, labor and manufacturing overhead.

  (vii) Property and Equipment

         Property and equipment are stated at cost. For financial reporting
purposes, depreciation is recognized using accelerated and straight-line
methods, allocating the cost of the assets over their estimated useful lives
ranging from five to ten years for certain manufacturing and laboratory
equipment, from three to five years for management information systems and
office equipment, three years for automobiles and thirty years for the building.
Leasehold improvements are amortized over the shorter of the life of the
improvement or the remaining life of the leases, which range from four to ten
years. Upon retirement or sale, the cost and related accumulated depreciation of
the asset are removed from the accounting records. Any resulting gain or loss is
credited or charged to income.

         In March of 1998, the American Institute of Certified Public
Accountants issued Statement of Position ("SOP") 98-1, "Accounting for the Costs
of Computer Software Developed or Obtained for Internal Use". SOP 98-1 requires
computer software costs associated with internal use software to be charged to
operations as incurred until certain capitalization criteria are met. SOP 98-1
is effective beginning January 1, 1999. The Company adopted this policy during
1999 as it implemented enterprise resource planning systems at two of its
locations. See Footnote 4 for further information.

  (viii) Goodwill and Intangibles

         The Company has classified as goodwill, the cost in excess of fair
value of the assets of the business acquired. Goodwill is being amortized on a
straight-line basis over ten to fifteen years. Other intangibles primarily
consist of patents, licenses, and intellectual property rights and are amortized
over periods ranging from four to sixteen years.

  (ix) Impairment of Long-Lived Assets

         The Company evaluates the potential impairment of its long-lived assets
  whenever events or changes in circumstances indicate that the carrying amount
  of an asset may not be recoverable. At the occurrence of a certain event or
  change in circumstances, the Company evaluates the potential impairment of an
  asset based on estimated future undiscounted cash flows. In the event
  impairment exists, the Company will measure the amount of such impairment
  based on the present value of estimated future cash flows using a discount
  rate commensurate with the risks involved. Based on management's assessment as
  of December 31, 1999, the Company has determined that no impairment of
  long-lived assets exists. Upon the occurrence of a material circumstance, such
  as the failure of certain technology to demonstrate promise that it may gain
  commercial acceptance or the failure of a business segment to achieve certain
  performance objectives, management will reassess the value of associated
  assets and if appropriate at that time, will recognize an impairment charge.
  The realizability of the goodwill related to the


                                      -39-
<PAGE>

                     BOSTON BIOMEDICA, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

  (1)  Business and Significant Accounting Policies (Continued)

  acquisition of BBI Source Scientific has been a specific area of focus by the
  Company. Management feels that although the business unit has realized
  operating losses since the acquisition in July 1997, the goodwill is not
  impaired as management believes the segment will be profitable by the end of
  2001.

  (x) Income Taxes

         The Company utilizes the liability method of accounting for income
  taxes. Under this method, deferred taxes arise from temporary differences
  between the financial statement and tax bases of assets and liabilities using
  enacted tax rates in effect in the years in which the differences are expected
  to reverse. A valuation allowance is provided for net deferred tax assets if,
  based on the weighted available evidence, it is more likely than not that some
  or all of the deferred tax assets will not be realized. Tax credits are
  recognized when realized using the flow through method of accounting. At
  December 31, 1999, the Company's entire valuation allowance related to the net
  operating losses acquired in connection with the BioSeq acquisition.
  Management feels that no additional valuation allowance is required as its tax
  strategies and normal profitability levels will allow it to realize all of its
  tax assets, including federal and state net operating losses and tax credits.

   (xi) Concentration of Credit Risk

         Financial instruments which potentially subject the Company to
concentrations of credit risk are principally cash and cash equivalents, and
accounts receivable. The Company places its cash in federally chartered banks,
each of which is insured up to $100,000 by the Federal Deposit Insurance
Corporation. The Company limits credit risk in cash equivalents by investing
only in short-term, investment grade securities including money market funds
restricted to such securities. Concentration of credit risk with respect to
accounts receivable is limited to certain customers to whom the Company makes
substantial sales (see Note 6). The Company does not require collateral from its
customers. To reduce risk, the Company routinely assesses the financial strength
of its customers and, as a consequence, believes that its trade accounts
receivable credit risk exposure is limited.

  (xii) Deferred Revenue

         Deferred revenue consists of payments received from customers in
advance of services performed.

  (xiii) Computation of Earnings per Share

         Basic earnings per share is computed by dividing income available to
  common shareholders by the weighted average number of common shares
  outstanding. Diluted earnings per share is computed by dividing income
  available to common shareholders by the weighted average common shares
  outstanding plus additional common shares that would have been outstanding if
  dilutive potential common shares had been issued. For purposes of this
  calculation, stock options are considered common stock equivalents in periods
  in which they have a dilutive effect. Options and warrants that were
  antidilutive were excluded from the calculation.

  (xiv) Segment Reporting

         The Company adopted SFAS No. 131, "Disclosures about Segments of an
Enterprise and Related Information," on December 31, 1998. SFAS No. 131
establishes standards for the way that public business enterprises report
information about operating segments in annual financial statements and requires
selected information about operating segments in interim financial reports. It
also establishes standards for related disclosures about products and services,
geographic areas and major customers. SFAS No. 131 supersedes SFAS No. 14,
Financial Reporting for Segments of a Business Enterprise, but retains the
requirements to report information about major customers. Disclosures required
by this new standard are included in the notes to the consolidated financial
statements under the caption "Segment Reporting and Related Information."

  (xv) Recent Accounting Standards

         Statement of Financial Accounting Standards No. 133, "Accounting for
Derivative Instruments and Hedging Activities" (SFAS 133)is effective, as
amended for quarters of fiscal years beginning after June 15, 2000. The new
standard requires companies to record derivatives on the balance sheet as assets
or liabilities, measured at fair value. Gains or losses resulting from changes
in the values of those derivatives would be accounted for depending on the use
of the derivatives and whether they qualify for hedge accounting. The key
criterion for hedge


                                      -40-
<PAGE>

                     BOSTON BIOMEDICA, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(1)  Business and Significant Accounting Policies (Continued)

accounting is that the hedging relationship must be highly effective in
achieving offsetting changes in fair value or cash flows. The Company does not
currently engage in derivative trading or hedging activity.

         In December 1999, the Staff of the Securities and Exchange
Commission issued Staff Accounting Bulletin No. 101, "Revenue Recognition in
Financial Statements" ("SAB 101"). This SAB summarizes certain of the Staff's
views in applying generally accepted accounting principles, in the United
States, to revenue recognition in financial statements. SAB 101 is effective
for the Company's quarter ended June 30, 2000. The Company does not expect
the provisions of SAB 101 to have a material impact on its financial
statements

 (2) Acquisition of BioSeq, Inc.

         On September 30, 1998 the Company acquired the remaining common stock
outstanding of BioSeq (approximately 81%) for $879,000 in cash (net of cash
acquired of $121,000), warrants to purchase 100,000 shares of the Company's
stock at an exercise price of $2.50 per share, minimum long-term royalty
payments of $424,000, debt and accrued interest owed by BioSeq at the time of
acquisition of approximately $736,000, and other acquisition costs. The Company
also exchanged BioSeq's stock options for 46,623 BBI stock options with an
average exercise price of $2.74. Accordingly, the Company's aggregate cost of
acquiring all of BioSeq's equity, including the original 19% investment under
the 1996 Purchase Agreement of $1,482,000 (classified as long-term investment at
December 31, 1997 was approximately $4,226,000. The cash portion of the
acquisition was financed from a combination of debt and cash. The acquisition
has been recorded using purchase accounting, and BioSeq's results are included
in the consolidated results of the Company commencing October 1, 1998.



         BBI BioSeq is a development stage company with patent pending
technology based on pressure cycling technology. The assets were capitalized
by allocating the aggregate cost of $4,226,000 ratably to the individual
components of the $11,124,000 total estimated fair value of the assets
acquired, based upon independent valuation of the assets
acquired as performed by the Michel/Shaked Group, a division of Back Bay
Management Company. Management believes that because of the Company's initial
investment in BioSeq, and intimate knowledge of its technology and business,
its understanding of the industry to which pressure cycling technology would
be applied, and as a result of lengthy and intense negotiations, the Company
was successful in reaching an extremely favorable purchase price for BioSeq
compared to the fair value of the assets acquired.

The assets acquired and their allocation are as follows

<TABLE>
<CAPTION>

                            ESTIMATED                      ALLOCATED
ITEM                       USEFUL LIFE    FAIR VALUE    PURCHASE PRICE
-----------------------  -------------    ----------    --------------
<S>                      <C>             <C>            <C>
Acquired In-process
 Research & development         -        $ 8,764,000        $3,381,000
Patents                       16 years     2,017,000           778,000
Other assets             3 to 10 years       343,000            67,000

Totals                                   $11,124,000        $4,226,000

</TABLE>



         Allocated in-process research and development consists of two projects,
that were on-going at the time of the acquisition: nucleic acid extraction and
purification and pathogen inactivation. BioSeq had expended approximately $1.6
million prior to September 30, 1998 on these projects. Both of these projects
have encouraging preliminary data demonstrating potential feasibility, but
significant scientific, mechanical and design issues remain. The Company
estimates that it will spend in excess of $4.8 million through the year 2002 to
complete the development into commercially viable products and to begin
generating revenue. Remaining development efforts are focused on feasibility
studies to establish the key performance parameters and biological activities to
be retained; designing and building a prototype instrument; further development
of the prototype for the applications; scale-up of design; data generation and
clinical trials; applying and obtaining Food and Drug Administration approval,
where applicable, final design modifications; and transfer to manufacturing. In
addition to the risk of the technology ultimately not working, failure to
complete on a timely basis could allow new or existing competing technologies to
be developed and commercially accepted.

         The valuation methodology was based on estimated discounted future cash
flows. Significant assumptions include gross and operating profit margins, and
future tax, discount, and royalty rates. Recent accounting guidelines on
valuation methodologies for in-process research and development are still
evolving and the amount written off maybe subject to adjustment.


                                      -41-
<PAGE>

                     BOSTON BIOMEDICA, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(2) Acquisition of BioSeq, Inc. (Continued)

         The following unaudited pro forma information combines the consolidated
results of operations of the Company and BioSeq as if the acquisition had
occurred at the beginning of 1997, after giving effect to certain adjustments,
including amortization of the intangible assets, increased interest expense on
the acquisition debt, and related income tax effects. The unaudited pro forma
information is shown for comparative purposes only and is based on management's
estimates of research and development expenditures.

<TABLE>
<CAPTION>
                                             Years Ended December 31,
                                          ----------------------------
                                             1998              1997
                                           Pro Forma        Pro Forma
                                          ----------        ----------
<S>                                       <C>               <C>
Revenues                                  26,081,077        22,299,337
Operating income (loss)                   (1,474,694)          191,952
Net income (loss)                           (989,327)          242,834
EPS                                            (0.21)             0.05
</TABLE>

         The pro forma information excludes acquired research and development of
$4,231,000

(3) Inventories

         The Company purchases human plasma and serum from various private and
commercial blood banks. Upon receipt, such purchases generally undergo
comprehensive testing, and associated costs are included in the value of raw
materials. Most plasma is manufactured into Basematrix and other diagnostic
components to customer specifications. Plasma and serum with the desired
antibodies or antigens are sold or manufactured into QC Panels, Accurun(R) Run
Controls, and reagents ("Finished Goods"). Panels and reagents are unique to
specific donors and/or collection periods, and require substantial time to
characterize and manufacture due to stringent technical specifications. Panels
play an important role in diagnostic test kit development, licensure and quality
control. Panels are manufactured in quantities sufficient to meet expected user
demand, which may exceed one year. Inventory also includes component parts used
in the manufacture of laboratory instrumentation. Inventory balances at December
31, 1999 and 1998 consisted of the following:

<TABLE>
<CAPTION>
                              1999                  1998
                           ----------            ----------
<S>                        <C>                   <C>
Raw materials ........     $2,675,735            $2,407,154
Work-in-process ......      1,845,778             1,788,399
Finished goods .......      2,396,403             2,494,215
                           ----------            ----------
                           $6,917,916            $6,689,768
                           ==========            ==========
</TABLE>

(4) Property and Equipment

         Property and equipment at December 31, 1999 and 1998 consisted of the
following:

<TABLE>
<CAPTION>
                                                   1999             1998
                                               -----------      -----------
<S>                                            <C>              <C>
Laboratory and manufacturing equipment ..      $ 3,456,410      $ 3,082,834
Management information systems ..........        3,691,338        2,556,193
Office equipment ........................        1,051,673          821,538
Automobiles .............................          318,242          206,693
Leasehold improvements ..................        2,177,236        1,610,260
Land, building and improvements                  2,611,733        2,307,039
                                               -----------      -----------
                                                13,306,632       10,584,557
Less accumulated depreciation ...........        5,011,608        3,659,134
                                               -----------      -----------

Net book value ..........................      $ 8,295,024      $ 6,925,423
                                               ===========      ===========
</TABLE>


                                      -42-
<PAGE>

                     BOSTON BIOMEDICA, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(4) Property and Equipment (Continued)

         Depreciation expense for the years ended December 31, 1999, 1998 and
1997 was approximately $1,359,000, $1,096,000, and $731,000 respectively.
Included in 1999, 1998 and 1997 land, building and improvements is approximately
$203,000, $1,345,000 and $920,000, respectively, of construction in progress.

         In accordance with SOP 98-1, the Company capitalized approximately
$448,000 of internal labor and related costs, in 1999, in connection with its
ERP System Implementation. These costs are included in the Management
Information Systems line item and are being depreciated over the same life as
the system, 5 years. Depreciation expense, related to these capitalized costs
was approximately $7,000 for the year ended December 31, 1999.

(5) Intangible Assets

         Intangible assets at December 31, 1999 and 1998 consisted of the
following:

<TABLE>
<CAPTION>
                                            1999                  1998
                                         ----------            ----------
<S>                                      <C>                   <C>
Goodwill .............................   $2,293,045            $2,293,045
Patents ..............................      795,880               796,380
Licenses .............................       37,752                37,752
                                         ----------            ----------
                                          3,126,677             3,127,177
Less accumulated amortization ........      537,367               317,352
                                         ----------            ----------

Net book value .......................   $2,589,310            $2,809,825
                                         ==========            ==========
</TABLE>

         Amortization expense for the years ended December 31, 1999, 1998 and
1997 was approximately $220,000, $184,000, and $125,000 respectively.

(6) Segment Reporting and Related Information (all dollar amounts in thousands)

         Operating segments are components of an enterprise for which separate
financial information is available that is evaluated regularly by senior
management in deciding how to allocate resources and in assessing performance of
each segment. The Company is organized along legal entity lines and senior
management regularly reviews financial results for all entities, focusing
primarily on revenue and operating income.



         The Company has five operating segments. The Diagnostics segment
serves the worldwide in vitro diagnostics industry, including users and
regulators of their test kits, with quality control products, and test kit
components. The BBI Biotech segment pursues third party contracts to help
fund the development of products and services for the other segments,
primarily with agencies of the United States Government. The Clinical
Laboratory Services segment performs specialty infectious disease testing for
hospitals, blood banks, doctors and other clinical laboratories, primarily in
North America. The Laboratory Instrumentation segment sells diagnostic
instruments primarily to the worldwide in vitro diagnostic industry on an OEM
basis, and also performs in-house instrument servicing. "Other" consists of
research and development in two areas: pressure cycling technology ("PCT")
and drug discovery. The Company performs research in the development of PCT,
with particular focus in the areas of nucleic acid purification and pathogen
inactivation. The Company also conducts active research, together with Dr. K.
H. Lee and collaborators at the School of Pharmacy, University of North
Carolina at Chapel Hill ("UNC"), in the area of anti-HIV drug discovery, with
exclusive focus on natural products and their synthetic derivatives. Finally,
the "Other" segment's two R&D operations do not currently have any product or
service revenue, and none is expected in the near future. Their revenue to
date consists of both private and public (NIH) funding of segment research.
Most of the expenditures by this segment are for R&D expenses, and general
management expenses including patent costs. The Company continues to seek
funding from both private and public sources to minimize the impact of their
development costs on the Company's overall operating results.



         The Company's underlying accounting records are maintained on a legal
entity basis for government and public reporting requirements, as well as for
segment performance and internal management reporting. Inter-segment sales are
recorded on a "third party best price" basis and are significant in measuring
segment operating results. Throughout 1999, the cost of most corporate functions
are included in the Diagnostic Products segment as the senior management group
has dual responsibility to this segment as well as the Company. Pursuant to the
August 1999 reorganization, many of the senior managers and a few other
employees were segregated from the Diagnostics segment to form a Corporate
operating unit, effective January 2000. The following segment


                                      -43-
<PAGE>

                     BOSTON BIOMEDICA, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(6) Segment Reporting and Related Information (Continued)

information has been prepared in accordance with the internal accounting
policies of the Company, as described above.

         Operating segment revenue for the years ended December 31, 1999, 1998
and 1997 were as follows:

<TABLE>
<CAPTION>
                                            1999          1998           1997
                                        ----------------------------------------
<S>                                      <C>            <C>            <C>
Diagnostics                              $ 11,837       $ 11,277       $ 10,655
BBI Biotech                                 6,297          5,355          4,188
Clinical Laboratory Services                9,842          7,187          6,024
Laboratory Instrumentation                  2,923          3,929          2,608
Other                                         434             --             --
Eliminations                               (2,062)        (1,667)        (1,176)
                                        ----------------------------------------
  Total Revenue                          $ 29,271       $ 26,081       $ 22,299
                                        ========================================
</TABLE>

         Operating segment (loss) income for the years ended December 31, 1999,
1998 and 1997 were as follows:

<TABLE>
<CAPTION>
                                            1999          1998           1997
                                        ----------------------------------------
<S>                                      <C>            <C>            <C>
Diagnostics                              $    784       $    559       $  1,357
BBI Biotech                                  (152)            67            (95)
Clinical Laboratory Services                  656            134            403
Laboratory Instrumentation                   (832)          (906)          (189)
Other                                      (1,345)          (525)           (84)
Acquired research & development                --         (4,231)            --
                                        ----------------------------------------
  Total (Loss) Income from Operations    $   (889)      $ (4,902)      $  1,392
                                        ========================================
</TABLE>

         Operating segment depreciation and amortization expense for the years
ended December 31, 1999, 1998 and 1997 were as follows:

<TABLE>
<CAPTION>
                                            1999          1998           1997
                                        ----------------------------------------
<S>                                      <C>            <C>            <C>
Diagnostics                              $    537       $    408       $    338
BBI Biotech                                   419            346            182
Clinical Laboratory Services                  240            217            175
Laboratory Instrumentation                    299            292            163
Other                                          84             17             --
                                        ----------------------------------------
  Total Depreciation and Amortization    $  1,579       $  1,280       $    858
                                        ========================================
</TABLE>

         Identifiable operating segment assets are all located in the United
States, and as of December 31, 1999, 1998 and 1997 were as follows:

<TABLE>
<CAPTION>
                                            1999          1998           1997
                                        ----------------------------------------
<S>                                      <C>            <C>            <C>
Diagnostics                              $ 13,375       $ 12,122       $ 14,152
BBI Biotech                                 4,643          4,242          2,806
Clinical Laboratory Services                3,188          2,348          1,948
Laboratory Instrumentation                  3,789          4,427          4,744
Other                                       1,167            943             --
                                        ----------------------------------------
  Total Assets                           $ 26,162       $ 24,082       $ 23,650
                                        ========================================
</TABLE>


                                      -44-
<PAGE>

                     BOSTON BIOMEDICA, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(6) Segment Reporting and Related Information (Continued)

         Operating segment capital expenditures for the years ended December 31,
1999, 1998 and 1997 were as follows:

<TABLE>
<CAPTION>
                                            1999          1998           1997
                                        ----------------------------------------
<S>                                      <C>            <C>            <C>
Diagnostics                              $  1,315       $  1,468       $  1,271
BBI Biotech                                   944          1,234            877
Clinical Laboratory Services                  307            202            196
Laboratory Instrumentation                    128             22            269
Other                                          34              4             --
                                        ----------------------------------------
  Total Capital Expenditures             $  2,728       $  2,930       $  2,613
                                        ========================================
</TABLE>

         Revenue by geographic area for the years ended December 31, 1999, 1998
and 1997 are as follows:

<TABLE>
<CAPTION>
                                            1999          1998           1997
                                        ----------------------------------------
<S>                                      <C>            <C>            <C>
United States                            $ 25,231       $ 21,978       $ 17,706
Europe                                      2,509          2,453          2,614
Pacific Rim                                   818          1,063          1,285
Total all others                              713            587            694
                                        ----------------------------------------
  Total                                  $ 29,271       $ 26,081       $ 22,299
                                        ========================================
</TABLE>

         Revenue of Product and Service classes in excess of 10% of consolidated
revenue (excludes inter-segment sales) for the years ended December 31, 1999,
1998 and 1997 were as follows:

<TABLE>
<CAPTION>
                                            1999          1998           1997
                                        ----------------------------------------
<S>                                      <C>            <C>            <C>
Quality Control Products                 $  9,445       $  9,369       $  8,220
Clinical Laboratory Testing                 9,472          6,806          5,695
Government Contracts                        4,530          3,535          2,638
</TABLE>

         The government contract revenues are from United States government
agencies, primarily the National Institutes of Health (NIH) and represent the
only customer with revenue in excess of 10% of consolidated revenue.

(7) Debt

         Effective June 30, 1999, the Company entered into an amended revolving
line of credit agreement (the "Amended Line") with its bank, increasing the
facility to $10 million from $7.5 million. The Amended Line matures June 30,
2001; bears interest at the Company's option based on either the base rate plus
1/4% or LIBOR plus 2.75%; carries a facility fee of 1/4% per annum, payable
quarterly; and is collateralized by substantially all of the assets of the
Company, excluding real property. Borrowings under the Amended Line are limited
to commercially standard percentages of accounts receivable, inventory and
equipment. The Company had approximately $456,000 available under the Amended
Line as of December 31, 1999.

         The Amended Line contains covenants regarding the Company's total
liabilities to tangible net worth ratio, minimum debt service coverage ratio,
and maximum net loss. The Amended Line further provides for restrictions on the
payment of dividends, incurring additional debt, and the amount of capital
expenditures.

         As of December 31, 1999 the Company's debt payment requirements under
its revolving line of credit were $0, $7,145,651, $0, $0 and $0 for the years
ended December 31, 2000, 2001, 2002, 2003, and 2004, respectively.


                                      -45-
<PAGE>

                     BOSTON BIOMEDICA, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(7) Debt (Continued)

         The Company's outstanding debt includes an installment note payable
with an interest rate of 9.75%, due August 2001. The note is collateralized by
office furniture and laboratory equipment. The Company also acquired two
additional notes for automobile loans, which are both being carried at 0%
financing and come due October 2002. The amounts outstanding, including the
current portion, at December 31, 1999 and 1998 were $22,414 and $26,820,
respectively.

(8) Other Liabilities

         The Company's California and Maryland facility's leases include
scheduled base rent increases over the term of the lease. The amount of base
rent payments is charged to expense using the straight-line method over the term
of the lease. As of December 31, 1999 and 1998, the Company has recorded a
long-term liability of $326,184 and $273,290, respectively ($361,413 and
$308,519 including the current portion) to reflect the excess of rent expense
over cash payments since inception of the lease. In addition to base rent, the
Company pays a monthly allocation of the operating expenses and real estate
taxes for the California and Maryland facilities.

         Included in long-term liabilities at December 31, 1999 and 1998 are the
present value of future minimum royalty payments of approximately $139,000 and
$424,000 payable to the former owners of BioSeq, Inc. (See Note 2).

(9) Accrued Compensation

         Accrued compensation consists of the following:

<TABLE>
<CAPTION>
                                   Year Ended December 31
                                   1999            1998
                                ----------      ----------
<S>                             <C>             <C>
Accrued payroll                 $  253,594      $  598,937
Accrued vacation                   447,534         360,509
Accrued commissions                305,423         177,691
Other accrued compensation         182,589         147,025
                                ----------      ----------
                                 1,189,140       1,284,162
                                ----------      ----------
</TABLE>

(10) Income Taxes

         The components of the (benefit) provision for income taxes are as
follows:

<TABLE>
<CAPTION>
                                                      1999            1998            1997
                                                    ---------       ---------       ---------
<S>                                                 <C>             <C>             <C>
Current (benefit) provision: federal                $(226,368)      $ (63,868)      $ 567,373
Current provision: state                            $  85,575       $  28,145       $ 100,125
                                                    ---------       ---------       ---------
  Total current (benefit) provision                  (140,793)        (35,723)        667,498

Deferred (benefit) provision: federal                (236,040)       (417,315)         (5,078)
Deferred (benefit) provision: state                  (122,139)       (111,361)          7,469
                                                    ---------       ---------       ---------
  Total deferred (benefit) provision                 (358,179)       (528,676)          2,391
                                                    ---------       ---------       ---------

    Total (benefit) provision for income taxes      $(498,972)      $(564,399)      $ 669,889
                                                    =========       =========       =========
</TABLE>

                                      -46-
<PAGE>

                     BOSTON BIOMEDICA, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(10) Income Taxes (Continued)

         Significant items making up deferred tax liabilities and deferred tax
assets were as follows:

<TABLE>
<CAPTION>
                                                                    1999              1998
                                                                -----------       -----------
<S>                                                             <C>               <C>
Current deferred taxes:
  Inventory                                                     $   174,338       $   169,796
  Accounts receivable allowance                                     298,271           224,240
  Technology licensed                                               299,883           322,516
  Other accruals                                                    162,298           130,716
                                                                -----------       -----------
    Total current deferred tax assets                               934,790           847,268
Long term deferred taxes:
  Accelerated tax depreciation                                     (335,880)         (279,358)
  Goodwill and intangibles                                           19,961            17,729
  Tax credits                                                       252,589            60,000
  Operating loss carryforwards                                    1,082,665           861,066
  Less: valuation allowance                                        (798,800)         (798,800)
                                                                -----------       -----------
    Total long term deferred tax assets (liabilities), net          220,535          (139,363)
                                                                -----------       -----------
    Total net deferred tax assets                               $ 1,155,325       $   707,905
                                                                ===========       ===========
</TABLE>

         On December 31, 1999 and 1998, operating loss carryforwards were
partially offset by a valuation allowance of $798,800. This allowance is to
reserve for the entire loss carryforward obtained through the acquisition of
BioSeq, Inc. The Company establishes valuation allowances in accordance with the
provisions of SFAS 109 "Accounting for Income Taxes". The Company continually
reviews the adequacy of the valuation allowance. The state net operating loss
carryforwards expire at various dates beginning in 2002 through 2019. As of
December 31, 1999, the Company had approximately $47,000 of alternative minimum
tax credits, which do not expire and approximately $205,000 of federal research
credits, which expire from 2012 through 2020. The Company has determined that no
additional valuation allowance is required. This conclusion is based on its
ability and intent to discontinue its operating loss position, not only for the
consolidated entity, but also for each of its operating segments. If
circumstances occur that change managements view about its ability to return to
profitability, and utilize the net operating losses and deferred tax assets, it
will re-evaluate its position with respect to valuation allowances.

         The Company's effective income tax rate differs from the statutory
federal income tax rate as follows:

<TABLE>
<CAPTION>
                                                                1999       1998       1997
                                                                ----       ----       ----
<S>                                                              <C>        <C>         <C>
Federal tax (benefit) provision rate                             (34%)      (34%)       34%
State tax (benefit) provision, net of federal benefit             (6%)       (1%)        6%
Nondeductable writeoff of acquired research and development                  23%        --
Other items, net                                                   2%         1%        --
                                                                ----       ----       ----
Effective income tax (benefit) provision rate                    (38%)      (11%)       40%
                                                                ====       ====       ====
</TABLE>

                                      -47-
<PAGE>

                     BOSTON BIOMEDICA, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(11) Commitments and Contingencies

         The Company leases certain office space, laboratory, research and
manufacturing facilities under operating leases with various terms through
October 2007. All of the real estate leases include renewal options at either
market or increasing levels of rent.

         Rent expense for the years ended December 31, 1999, 1998 and 1997 was
approximately $1,218,000, $914,000, and $506,000, respectively. At December 31,
1999, the remaining fixed lease commitment was as follows:

<TABLE>
<CAPTION>
               Year Ended                                        Amount
          -------------------                                -------------
<S>                                                             <C>
          2000                                                  1,168,617
          2001                                                  1,106,646
          2002                                                    846,256
          2003                                                    864,470
          2004                                                    889,687
          2005 and thereafter                                   2,372,466
                                                             -------------
                                                               $7,248,142
                                                             -------------
</TABLE>

         In April 1999, the Company increased it's commitment to directly
support a drug discovery program at UNC, in which a full-time post-doctoral
research scientist and two doctoral students are working to develop synthetic
derivatives of anti-HIV compounds that have been discovered pursuant to the
Company's joint collaboration with UNC. The Company is committed to pay
approximately $44,000 per quarter for three years. These costs are being charged
to research and development expense. Under this agreement , the Company will
also have the rights to any new anti-HIV compounds and derivatives developed in
the course of this sponsored research, provided the Company obtains certain
regulatory approvals from the FDA. Effective January 2000, all rights and
obligations under this agreement were transferred to Panacos Pharmaceuticals,
Inc.

(12) Retirement Plan

         In January 1993, the Company adopted a retirement savings plan for its
employees, which has been qualified under Section 401(k) of the Internal Revenue
Code. Eligible employees are permitted to contribute to the plan through payroll
deductions within statutory limitations and subject to any limitations included
in the plan. Company contributions are made at the discretion of management. To
date, no such contributions have been made. During 1999, 1998 and 1997 the
Company recognized administrative expense of approximately $30,000, $32,000, and
$23,000, respectively in connection with the plan.

(13) Stockholders' Equity

     Common Stock

         In July 1999, the Company's Board of Directors approved the 1999
 Employee Stock Purchase Plan. The Company adopted this plan, which allows
 eligible employees to purchase shares of the Company's stock at 85% of market
 value as determined at the beginning and the end of the offering period. A
 total of 250,000 shares have been reserved for this plan. As of December 31,
 1999 no shares were issued under this plan.

     Options and Warrants

         The Company has a nonqualified stock option plan and an incentive stock
option plan (1996 Employee Stock Option Plan) both of which are administered by
a committee of the Board of Directors. In July 1999 the Company's Board of
Directors approved the designation of an additional 1,250,000 shares to become
available for distribution under the 1996 Employee Stock Option Plan. The Board
of Directors also approved the 1999 Non-


                                      -48-
<PAGE>

                     BOSTON BIOMEDICA, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(13) Stockholders' Equity-(Continued)

Qualified Stock Option Plan, and designated 500,000 shares for distribution
under this plan. The exercise price of an option generally equals the fair
market value of the stock at grant date. Generally, options become exercisable
at the rate of 25% at the end of each of the four years following the
anniversary of the grant. Options expire ten years from the date of grant, or 30
days from the date the grantee's affiliation with the Company terminates.

         At December 31, 1999, 1,999,500 shares were reserved for incentive
stock options, of which 1,328,624 are available for future grants. At December
31, 1998, 749,500 shares have been reserved for incentive stock options, of
which 179,887 are available for future grants. At December 31, 1999, 1,098,680
shares were reserved under the nonqualified stock option plan of which 489,951
were available for future grants. As of December 31, 1998, 605,929 shares were
reserved for the non-qualified stock option plan of which no shares were
available for future grants.

         In August 1999, the Company sold 500,000 warrants to purchase the
Company's stock to Paradigm Group, a private investment company. The private
placement consisted of 400,000 common stock purchase warrants with a exercise
price of $4.25 and 100,000 common stock purchase warrants with an exercise price
of $5.25. Paradigm Group paid the Company $50,000 for the warrants. In addition,
National Securities received 40,000 common stock purchase warrants with an
exercise price of $4.25, 10,000 common stock purchase warrants with an exercise
price of $5.25, and 25,000 common stock purchase warrants with an exercise price
of $8.00, as transaction fee.

         In November 1999, the Company sold 29,153 equity units to MDBio, Inc.,
a Maryland not-for-profit corporation. Each equity unit consists of one share of
common stock and one common stock purchase warrant with an exercise price of
$10.00. MDBio paid the Company $175,000 for the equity units and has until
September 2003 to exercise the warrants.

         On December 11, 1998, the Company's Board of Directors authorized the
Company to offer a reduction of the stock option exercise price to $3.25 per
share, which represented a premium over the market price of $2.56 on that day.
Any option holder with outstanding stock options with an exercise price higher
than $3.25 was eligible to participate in the repricing. A total of 411,417
options were repriced, which represents substantially all eligible options. The
original vesting schedule, generally four years from date of grant, remained
unchanged. However, all optionees accepting the offer agreed not to exercise
vested, repriced options for a period of one year from the date of amendment.
The previous weighted average exercise price of the options repriced was $6.72.

         The Company has elected to follow Accounting Principles Board Opinion
No. 25, "Accounting for Stock Issued to Employees" (APB 25) and related
interpretations in accounting for its employee stock options. Under APB 25,
because the exercise price of employee stock options equals the market price of
the underlying stock on the date of grant, no compensation expense is recorded.
The Company has adopted the disclosure-only provisions of Statement of Financial
Accounting Standards No. 123, "Accounting for Stock-Based Compensation" (SFAS
123). Pro forma information regarding net income and earnings per share is
required by SFAS 123 and has been determined as if the Company had accounted for
its employee stock options under the fair value method of that statement. The
fair value of these options was estimated at the date of grant using a
Black-Scholes option pricing model with the following weighted average
assumptions for 1999, 1998 and 1997. The minimum value option pricing model was
used for all grants during, and prior to, 1996 as they were granted prior to the
Company's IPO.

<TABLE>
<CAPTION>
                                                      1999                 1998                 1997
                                                  -------------        -------------        -------------
<S>                                                  <C>                  <C>                  <C>
           Risk-free interest rate                       5.26%                4.69%                5.72%
           Volatility factor                            76.68%               75.57%               55.00%
           Weighted average expected life            5.1 years            5.0 years            5.0 years
           Expected dividend yield                           0                    0                    0
</TABLE>

         The Black-Scholes option valuation model was developed for use in
estimating the fair value of traded options, which have no vesting restrictions
and are fully transferable. In addition, option valuation models require the
input of highly subjective assumptions including the expected stock price
volatility. Because the Company's employee stock options have characteristics
significantly different from those of traded options, and because changes in the
subjective input assumptions can materially affect the fair value estimate, in
management's opinion,


                                      -49-
<PAGE>

                     BOSTON BIOMEDICA, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(13) Stockholders' Equity-(Continued)

the existing models do not necessarily provide a reliable single measure of the
fair value of its employee stock options.

         For purposes of pro forma disclosures, the estimated fair value of the
options is amortized to expense over the options' vesting period. The Company's
pro forma net income and pro forma net income per share is as follows:

<TABLE>
<CAPTION>
                                                                 1999                 1998                 1997
                                                             --------------       --------------       --------------
<S>                                                           <C>                  <C>                    <C>
         Net (loss) income-as reported                          $(814,112)         $(4,388,719)           $1,004,834
         Net (loss) income-pro forma                          $(1,394,564)         $(4,776,812)              851,408
         Net (loss) income per share-as reported, basic              (.17)                (.94)                  .23
         Net (loss) income per share-as reported, diluted            (.17)                (.94)                  .21
         Net (loss) income per share-pro forma, basic                (.30)               (1.03)                  .19
         Net (loss) income per share-pro forma, diluted              (.30)               (1.03)                  .18
</TABLE>

         Because SFAS 123 provides for pro forma expense for options granted
beginning in 1995, the pro forma expense will likely increase in future years as
new option grants become subject to the pricing model. The average fair value of
options granted during 1999, 1998 and 1997 is estimated as $2.63, $1.77 and
$4.44, respectively.


                                      -50-
<PAGE>

                     BOSTON BIOMEDICA, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(13) Stockholders' Equity-(Continued)

         The Company has reserved shares of its authorized but unissued common
stock for the following:

<TABLE>
<CAPTION>
                                                    Stock Options                  Warrants
                                             --------------------------   ---------------------------
                                                            Weighted                     Weighted                  Total
                                                          Average price                Average price    --------------------------
                                                Shares      per share      Shares        per share       Shares       Exercisable
                                             ---------    -------------   --------    ---------------   ---------    --------------
<S>                                          <C>              <C>         <C>              <C>          <C>            <C>
Balance outstanding, December 31, 1996         917,887        3.10         280,000           7.63        1,197,887       839,272
  Granted                                      263,050        7.42              --             --          263,050
  Exercised                                   (124,409)       1.44        (120,000)          2.50         (244,409)
  Expired                                      (30,435)       7.36              --             --          (30,435)
                                             ---------                    --------                       ---------
Balance outstanding, December 31, 1997       1,026,093        4.28         160,000          11.48        1,186,093       832,231
  Granted                                      358,836        3.80 *       100,000           2.50          458,836
  Exercised                                    (45,250)       1.97              --             --          (45,250)
  Expired                                     (165,013)       6.05              --             --         (165,013)
                                             ---------                    --------                       ---------
Balance outstanding, December 31, 1998       1,174,666        2.75 **      260,000           8.34        1,434,666       829,434
  Granted                                      260,500        3.91         579,153           4.73          839,653
  Exercised                                    (47,249)       0.52          (5,000)          2.50          (52,249)
  Expired                                     (107,688)       3.56              --             --         (107,688)
                                             ---------                    --------                       ---------
Balance outstanding, December 31, 1999       1,280,229        3.00         834,153           5.80        2,114,382     1,591,795
                                             =========                    ========                       =========
</TABLE>

* Includes 46,623 shares at $2.74 granted in connection with the BioSeq, Inc.
  acquisition.

* Includes the effect of 411,417 options repriced in December 1998 from a
  weighted average price of $6.72 to $3.25 per share.

The following table summarizes information concerning options outstanding and
exercisable as of December 31, 1999:

<TABLE>
<CAPTION>
                                              Options Outstanding                    Options Exercisable
                           Weighted        --------------------------------     -------------------------------
                            Average                            Weighted                            Weighted
                           Remaining       Number of            Average         Number of           Average
Range of Exercise Prices      Life          Options          Exercise Price      Options         Exercise Price
------------------------   ---------       ---------         --------------     ---------        --------------
<S>                           <C>            <C>                <C>              <C>                <C>
      0.00-1.70               1.20           184,334            $ 1.5062         184,334            $ 1.5062
      1.71-2.55               2.80           189,767            $ 2.5000         189,767            $ 2.5000
      2.56-3.25               6.80           746,378            $ 3.2054         380,541            $ 3.1925
      3.26-4.25               9.60           131,750            $ 4.2500              --            $ 0.0000
      4.26-5.10               9.00            28,000            $ 4.6563           3,000            $ 4.5000
                                         -----------                           ---------
                                           1,280,229                             757,642
                                         ===========                           =========
</TABLE>


                                      -51-
<PAGE>

                     BOSTON BIOMEDICA, INC. AND SUBSIDIARIES

                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

(14) Computation of Net Income per Share

         The following illustrates the computation of basic and diluted net
income per share.

<TABLE>
<CAPTION>
                                                            Year Ended December 31,
                                                ----------------------------------------------
                                                    1999              1998             1997
                                                -----------       -----------      -----------
<S>                                             <C>               <C>              <C>
Shares, basic                                     4,669,717         4,654,609        4,437,801

Net effect of dilutive common stock
  equivalents-based on treasury stock
  method using average market price *                                                  342,269
                                                -----------       -----------      -----------
Shares, diluted                                   4,669,717         4,654,609        4,780,070
                                                ===========       ===========      ===========

Net (loss) income, basic and diluted            $  (814,112)      $(4,388,719)     $ 1,004,834
                                                ===========       ===========      ===========

Net (loss) income per share-basic                     (0.17)            (0.94)            0.23
Net (loss) income per share-diluted                   (0.17)            (0.94)            0.21
</TABLE>

         * Potentially dilutive securities of 68,023 and 192,826 were not
         included in the computation of diluted earnings per share because to do
         so would have been antidilutive for twelve months ended December 31,
         1999 and 1998.

(15) Selected Quarterly Financial Data (Unaudited)

         Unaudited (Amounts in thousands, except for per share data)

<TABLE>
<CAPTION>
1999                                            1st Qtr             2nd Qtr             3rd Qtr             4th Qtr
                                                -------             -------             -------             -------
<S>                                             <C>                 <C>                 <C>                 <C>
Total revenue                                   $ 6,845             $ 7,139             $ 7,480             $ 7,807
Gross profit                                      2,566               2,675               2,905               2,689
Net (loss)                                         (237)               (225)               (257)                (96)
Net (loss) per share, basic                       (0.05)              (0.05)              (0.05)              (0.02)
Net (loss) per share, diluted                     (0.05)              (0.05)              (0.05)              (0.02)

<CAPTION>
1998                                            1st Qtr             2nd Qtr             3rd Qtr             4th Qtr
                                                -------             -------             -------             -------
<S>                                             <C>                 <C>                 <C>                 <C>
Total revenue                                   $ 6,273             $ 6,383             $ 6,181             $ 7,244
Gross profit                                      2,178               2,709               2,448               2,669
Net (loss) income                                  (645)                134              (3,377)               (502)
Net (loss) income per share, basic                (0.14)               0.03               (0.72)              (0.11)
Net (loss) income per share, diluted              (0.14)               0.03               (0.72)              (0.11)
</TABLE>


                                      -52-
<PAGE>

                        Report of Independent Accountants

To the Board of Directors and Stockholders
of Boston Biomedica, Inc.:

In our opinion, the consolidated financial statements listed in the accompanying
index present fairly, in all material respects, the financial position of Boston
Biomedica, Inc. and its subsidiaries (the "Company") at December 31, 1999 and
1998, and the results of their operations and their cash flows for each of the
three years in the period ended December 31, 1999 in conformity with accounting
principles generally accepted in the United States. In addition, in our opinion,
the financial statement schedule listed in the accompanying index presents
fairly, in all material respects, the information set forth therein when read in
conjunction with the related consolidated financial statements. These financial
statements and financial statement schedule are the responsibility of the
Company's management; our responsibility is to express an opinion on these
financial statements and financial statement schedule based on our audits. We
conducted our audits of these statements in accordance with auditing standards
generally accepted in the United States, which require that we plan and perform
the audit to obtain reasonable assurance about whether the financial statements
are free of material misstatement. An audit includes examining, on a test basis,
evidence supporting the amounts and disclosures in the financial statements,
assessing the accounting principles used and significant estimates made by
management, and evaluating the overall financial statement presentation. We
believe that our audits provide a reasonable basis for the opinion expressed
above.


/s/ PricewaterhouseCoopers LLP


Boston, Massachusetts
February 29, 2000


                                      -53-
<PAGE>

ITEM 9.  CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND
         FINANCIAL DISCLOSURE

         None.

                                    PART III

ITEM 10. DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT

         The information called for by Item 10 is hereby incorporated by
reference to the information under Part I, Item 1 - Business under the heading
"Executive Officers of the Registrant" at page [18] of this report, and to the
information in the registrant's definitive proxy statement, which is expected to
be filed by the registrant within 120 days after the close of its fiscal year.


ITEM 11. EXECUTIVE COMPENSATION

         The following summary compensation table sets forth the compensation of
the Company's Chief Executive Officer and each of the Company's four most highly
compensated other executive officers who were serving as executive officers of
the Company at the end of fiscal year 1999 (collectively, the "Named Executive
Officers").

                           Summary Compensation Table

<TABLE>
<CAPTION>
                                                                                             Long Term
                                                       Annual Compensation                   ---------
                                                       -------------------                  Compensation
                                                                                            ------------
                                Fiscal                                   Other Annual                            All Other
          Name and               Year         Salary         Bonus       Compensation      Stock Options        Compensation
     Principal Position          Ended          ($)           ($)              $                (#)                  ($)
     ------------------         ------        -------       -------      ------------      -------------        ------------
<S>                            <C>             <C>           <C>           <C>                 <C>             <C>
Richard T. Schumacher,         12/31/99       $229,010         --          $1,520(1)           25,000          $184,450(2)(4)
 Chief Executive Officer       12/31/98        200,002       $5,000           370(1)           15,000               420(2)
 and Chairman of the Board     12/31/97        194,616         --           1,588(1)             --                 420(2)

Kevin W. Quinlan,              12/31/99       $168,075         --             --               17,500                --
 President , Chief             12/31/98        143,347       $4,000           --               10,000                --
 Operating Officer and         12/31/97        139,927         --             --                 --                  --
 Director

Barry M. Warren                12/31/99       $147,547         --             --               10,000                --
 Senior Vice President and     12/31/98        137,601       $3,000           --                6,000                --
 General Manager               12/31/97        129,367         --             --                 --                  --

Richard C. Tilton, Ph.D.       12/31/99       $135,203         --          $6,000(3)             --                  --
 Senior Vice President,        12/31/98        127,019       $3,000         6,000(3)           6,000                 --
 Science and Technology        12/31/97        121,164         --           6,000(3)             --                  --

Mark M. Manak, Ph.D.           12/31/99       $129,894         --             --                 --                  --
 Senior Vice President and     12/31/98        118,510       $3,000           --               6,000                 --
 General Manager               12/31/97        116,388         --             --                 --                  --
</TABLE>

--------------------

(1) Consists of personal usage of Company vehicle
(2) Includes the value of premiums paid for a term life insurance policy.
(3) Consists of automobile allowance
(4) Consists of exercise of options


                                      -54-
<PAGE>

         The following table shows stock options granted to the Named Executive
Officers in fiscal 1999:

                       Options Granted in Fiscal Year 1999

<TABLE>
<CAPTION>
                                                   Individual Grants                             Potential Realizable Value at
                              -------------------------------------------------------------      Assumed Annual Rates of Stock
                               Number of        % of Total                                            Price Appreciation
                               Securities         Options         Exercise                        for Option Term at Year End
                               Underlying       Granted to       ----------    ------------     --------------------------------
                                Options        Employees in      Price         Expiration
            Name                Granted            1999           ($/Sh.)         Date               5%              10%
            ----              -------------    --------------    ---------- -- ------------     ------------- ------------------
<S>                              <C>               <C>             <C>           <C>                <C>            <C>
Richard T. Schumacher            25,000            9.60%           4.675         07/27/09           56,195         158,710
Kevin W. Quinlan                 17,500            6.72%           4.25          07/27/09           46,774         118,535
Barry M. Warren                  10,000            3.84%           4.25          07/27/09           26,728          67,734
Richard C. Tilton, Ph.D.           --               --              --              --                --              --
Mark M. Manak, Ph.D.               --               --              --              --                --              --
</TABLE>

         The following table shows stock options exercised by the Named
Executive Officers during fiscal 1999, including the aggregate value realized
upon exercise. This represents the excess of the fair market value over the
purchase price at the time of purchase. In addition, this table includes the
number of shares underlying both "exerciseable" (i.e. vested) and
"unexerciseable" (i.e. unvested) stock options as of December 31, 1999. Also
reported are the values of "in-the-money" options, which reflect the positive
spread between the exercise price of any such existing stock options and the
closing year end per share price of the Common Stock of $2.875.

                       Aggregated Option Exercises in Last
                  Fiscal Year and Fiscal Year End Option Values

<TABLE>
<CAPTION>
                                                                   Number of Securities                Value of Unexercised
                                 Shares                           Underlying Unexercised               In-the-Money Options
                                Acquired                           Options at Year End                     at Year End
                                   on          Value (1)      ----------------------------        ----------------------------
            Name                Exercise       Realized       Exercisable    Unexercisable        Exercisable    Unexercisable
            ----                --------       --------       -----------    -------------        -----------    -------------
<S>                              <C>           <C>                  <C>               <C>             <C>             <C>
Richard T. Schumacher            40,000        $180,000             98,690            38,690          $103,827        $164
Kevin W. Quinlan,                  --             --                71,250            26,250           $44,375         --
Barry M. Warren                    --             --                33,375            20,125                --         --
Richard C. Tilton, Ph.D.           --             --                38,375             5,125                --         --
Mark M. Manak, Ph.D.               --             --                38,375            10,125                --         --
</TABLE>

-------------------
(1) Based upon the closing price of the Common Stock on the Nasdaq National
Market on the date of exercise, minus the respective option exercise price.

Compensation of Directors

         Directors of the Company do not receive cash compensation for their
services. Each Director has been eligible to receive options to purchase Common
Stock under the Company's 1987 Non-Qualified Stock Option Plan, which expired in
December 1997, and the Company's 1999 Nonqualified Stock Option Plan.

Compensation Committee Interlocks and Insider Participation

         Decisions regarding executive compensation are made by the Board of
Directors based on the recommendations of the Compensation Committee. The
Compensation Committee of the Board of Directors is comprised of Richard T.
Schumacher and Calvin A. Saravis, each of whom has received


                                      -55-
<PAGE>

options to purchase Common Stock. Mr. Schumacher serves as the Chief Executive
Officer of the Company. Mr. Saravis is neither a former nor current officer or
employee of the Company.

ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

         The information called for by Item 12 is hereby incorporated by
reference to the information in the registrant's definitive proxy statement
under the heading "Security Ownership of Directors, Officers and Certain
Beneficial Owners," which is expected to be filed by the registrant within 120
days after the close of its fiscal year.

ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS.

         The information called for by Item 13 is hereby incorporated by
reference to the information in the registrant's definitive proxy statement
under the heading "Certain Relationships and Related Transactions," which is
expected to be filed by the registrant within 120 days after the close of its
fiscal year.


                                      -56-
<PAGE>

                                     PART IV

ITEM 14. EXHIBITS, FINANCIAL STATEMENT SCHEDULES AND REPORTS ON FORM 8-K.

<TABLE>
<S>                                                                                                       <C>
(a) 1. Index to Financial Statements:
       Consolidated Balance Sheets as of December 31, 1999 and 1998.......................................31
       Consolidated Statements of Income for the three years ended December 31, 1999......................32
       Consolidated Statements of Changes in Stockholders' Equity for the three years ended
                    December 31, 1999.....................................................................33
       Consolidated Statements of Cash Flows for the three years ended December 31, 1999..................34
       Notes to Consolidated Financial Statements.........................................................35
       Report of Independent Accountants..................................................................50
(a) 2. Financial Statement Schedule:
       Schedule II-Valuation and Qualifying Accounts......................................................60
</TABLE>

       All supplemental schedules other than as set forth above are omitted as
inapplicable or because the required information is included in the Consolidated
Financial Statements or the Notes to Consolidated Financial Statements.

(a) 3. Exhibits:

<TABLE>
<CAPTION>
       Exhibit No.                                                                                      Reference
       -----------                                                                                      ---------
       <S>        <C>                                                                                <C>
       3.1        Amended and Restated Articles of Organization of the Company                             A**

       3.2        Amended and Restated Bylaws of the Company                                               A**

       4.1        Specimen Certificate for Shares of the Company's Common Stock                            A**

       4.2        Description of Capital Stock (contained in the Restated Articles of                      A**
                  Organization of the Company filed as Exhibit 3.1)

       4.3        Form of warrants issued in connection with Paradigm Group                                H**

       10.1       Agreement, dated January 17, 1994, between Roche Molecular Systems, Inc. and             A**
                  the Company

       10.2       Exclusive License Agreement, dated April 28, 1999, between the University of       Filed herewith
                  North Carolina at Chapel Hill and the Company

       10.3       Agreement, dated October 1, 1995, between Ajinomoto Co., Inc. and the Company            A**

       10.4       Lease Agreement, dated July 28, 1995, for New Britain, Connecticut Facility              A**
                  between MB Associates and the Company

       10.5       1987 Non-Qualified Stock Option Plan*                                                    A**

       10.6       Employee Stock Option Plan*                                                              A**

       10.7       1999 Non-Qualified Stock Option Plan*                                                    I**

       10.8       1999 Employee Stock Purchase Plan*                                                       I**

       10.9       Underwriters Warrants, each dated November 4, 1996, between the Company and              B**
                  each of Oscar Gruss & Son Incorporated and Kaufman Bros., L.P.
</TABLE>


                                      -57-
<PAGE>

<TABLE>
<CAPTION>
       Exhibit No.                                                                                      Reference
       -----------                                                                                      ---------
       <S>        <C>                                                                                <C>
       10.10      Commercial Loan Agreement, as of dated March 28, 1997, between The First                 C**
                  National Bank of Boston and the Company

       10.11      Contract, dated March 1, 1997, between National Cancer Institute and the Company         D**

       10.12      Lease Agreement, dated May 16, 1997, for Gaithersburg, Maryland facility                 E**
                  between B.F. Saul Real Estate Investment Trust and the Company

       10.13      Lease Agreement  dated January 30, 1995 for Garden Grove, California facility            F**
                  between TR Brell, Cal Corp. and Source Scientific, Inc., and Assignment of
                  Lease, dated July 2, 1997, for Garden Grove, California facility between Source
                  Scientific, Inc. and BBI Source Scientific

       10.14      Contract, dated July 1, 1998, between  the National Institutes of Health and             G**
                  the Company (NO1-A1-85341)

       10.15      Contract, dated July 1, 1998, between the National Heart Lung and Blood                  G**
                  Institute and the Company (NO1-HB-87144)

       10.16      Line of Credit Agreement with BankBoston dated June 30, 1999                             H**

       10.17      Agreement with Paradigm Group for the purchase of warrants dated August 18, 1999         H**

       10.18      Agreement with MDBio for the purchase of common stock and common stock             Filed herewith
                  warrants, dated September 30, 1999

       10.19      Lease Agreement dated September 30, 1999, for Frederick, Maryland facility,        Filed herewith
                  between MIE Properties, Inc., and the Company.

       10.20      Sponsored Research Agreement with the University of North                          Filed herewith
                  Carolina, Chapel Hill and the Company, dated, April 28, 1999 and the Company.

       10.21      Repository Contract with National Institute of Allergy and                         Filed herewith
                  Infectious Disease, Division of AIDS (NO1-A1-95381), dated August 16, 1999.

       21.1       Subsidiaries of the registrant                                                     Filed herewith

       23         Consent of PricewaterhouseCoopers LLP                                              Filed herewith

       27         Financial Data Schedule                                                            Filed herewith

       99         Audited Financial Statements of BioSeq, Inc., for the years ended December 31,     Filed herewith
                  1997, 1996 and for the period October 17, 1994 (Date of Inception) to
                  December 31, 1997.
</TABLE>

A      Incorporated by reference to the registrant's Registration Statement on
       Form S-1 (Registration No. 333-10759) (the "Registration Statement"). The
       number set forth herein is the number of the Exhibit in said Registration
       Statement.
B      Incorporated by reference to Exhibit No. 10.17 of the Registration
       Statement.
C      Incorporated by reference to the registrant's Annual Report on Form 10-K
       for the fiscal year ended December 31, 1996.
D      Incorporated by reference to the registrant's Quarterly Report on Form
       10-Q for the fiscal quarter ended March 31, 1997.
E      Incorporated by reference to the registrant's Quarterly Report on Form
       10-Q for the fiscal quarter ended June 30, 1997.


                                      -58-
<PAGE>

F      Incorporated by reference to the registrant's Annual Report on Form 10-K
       for the fiscal year ended December 31, 1997.
G      Incorporated by reference to the registrant's Quarterly Report on Form
       10-Q for the fiscal quarter ended June 30, 1998.
H      Incorporated by reference to the registrant's Quarterly Report on Form
       10-Q for the fiscal quarter ended September 30, 1999.
I      Incorporated by reference to the registrant's proxy statement, filed with
       the Securities and Exchange Commission on June 14, 1999.

*      Management contract or compensatory plan or arrangement.
**     In accordance with Rule 12b-32 under the Securities Exchange Act of 1934,
       as amended, reference is made to the documents previously filed with the
       Securities and Exchange Commission, which documents are hereby
       incorporated by reference.

(b) REPORTS ON FORM 8-K.

                  The Registrant did not file any Current Reports on Form 8-K
during the quarter ended December 31, 1999.


                                      -59-
<PAGE>

                                   SIGNATURES

                  Pursuant to the requirements of Section 13 or 15(d) of the
Securities Exchange Act of 1934, the registrant has duly caused this report to
be signed on its behalf by the undersigned, thereunto duly authorized.



Date: December 7, 2000              Boston Biomedica, Inc.


                                    By:    /s/ Richard T. Schumacher
                                           Richard T. Schumacher
                                           Chief Executive Officer



                  Pursuant to the requirements of the Securities Exchange Act of
1934, this report has been signed below by the following persons on behalf of
the registrant and in the capacities and on the dates indicated.

<TABLE>
<CAPTION>
         SIGNATURES                                  TITLES                                      DATE
         ----------                                  ------                                      ----
<S>                                                  <C>                                         <C>

                                                     Director and Principal                      March 28, 2000
         -----------------------------------         Executive Officer
         Richard T. Schumacher

                                                     Director and Principal                      March 28, 2000
         -----------------------------------         Accounting and Financial Officer
         Kevin W. Quinlan

                                                     Director                                    March 28, 2000
         -----------------------------------
         Francis E. Capitanio

                                                     Director and Treasurer                      March 28, 2000
         -----------------------------------
         Dr. William R. Prather, MD.

                                                     Director                                    March 28, 2000
         -----------------------------------
         Calvin A. Saravis, Ph.D.
</TABLE>


                                      -60-