# EPA Reg. No. 264
-418 Vol. 1 (this copy does not include records prior to April 1991)

### RHONE·POULENG AG OOMPANY 

## Ms. Terry Stowe BPA Registr"tlon Division 

## TEAM 22**~.;"'.lj$~** [It,S



### _"" ± 

### _""4 ""

...



## November 19, 1993



## RE:**PREP<~** 

## Piant Regulator For Cotton EPA Reg. No 264·418 

# ,



# -

Based upon yourphone

## me~sage ofNovember 19, 1993 

## pieasebe 

## advised that we do 

## request an expedited review for the Prep alternate formulation request. The submission was initially**!ll~d** 

## onJanuary 30, 1993 

## and simpiy removed the additives that wete used as markers 

## \0 identify the source of supply for the active ingrdient in the formulated product.

.

• As • 

## prerequisite to

# .pprov~l of the amended formuiation for Prep we were asked to amend our basic 

## formulatl<)n to identify the source of suppiy for etIlepIlon. 

## TIlts action was compieted with an EPA acceptance dated November 8,1993. 

## We now have immediate need for the**a1t~rnate** 

## formuiatlon approvai to 

## allow manufacture of our 1994 

## Prep Piant Reguiator Inventory which is set (0

## begin 

## in mid January, 1994. 

## We wouid appreciate EPA**~PPl'oval** 

## of the alternate formulation for Prep as soon as possible. If

# you have any**~uestiollS** 

## piease contact me prompUy.

Thanks for your heip.

# &I~,. 

# A'**.tbv~** • Warren A. I)avis
Senior Regi!;tratlon Manager

POBOX 12Q14,21W N.f**~Nif;!}**..af"\\'(t m:SEMCHTI'IlANG:EPARf{ rIC ;'7WJ 

### ,

(1II9)MrHOOO I l"ItEIl,"iAlIONAL lEt!;X**!rJ',~m** 11**~9)"~1b·'A1';$1~(fl\1I'1f,** J,,,Cj>:P • • ttJt£I'WAHOUAL f)1f;'RIHV;;?'1.'>[R'IIC,STEl f)( N\JVurn**~S:;n:;lf** .Al

..SWfq[IAO'; rrc "y, 

# 1FROM RHOil[-POULEHC pj CO-EPG'C



### ""'",._:w ,s:_
.. 

### RHONQ·POULENC AG CpMPANY I 

### ENVIRONMliNTAL,REGULATony& 

### PtroLlCAFFAIRS DEPARTM1lNT 

### PO Box 12014,2TW

## AlexanderDrive' ResearchTriahglePark, N.C. 27700 Fax Number: (919):549-2545

URGENT,.k.. YES _ND 

# ! PAX

# CO\,ER SHEET 

# ==:J

DATE:.-.L// 

# /fIP5

FROM: Wlll'll1<lV 

# QIlv,.i--': TELEPHONE NO. 1"/2

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### NUMBER OF

### PAGES (INCLUDINGTHIS

### SHEET):

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# ., Ifmessage Is nollc{;lbleor all pages 

## n6t re<:eived,please adviseus by 

### fax orph:)nc. 

# ===-____.. ________ '
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## MESSAGE: 

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# 2- ---- 

## -------**---~~--.--------** 

# (i! RHONE-POULENC



# •

• RHONe·POULENC AG COMPANY 

## Document Processing Desk (FIN-LABEL) Office ofPesticidePrograms (H-7504-C) U. S. Environmental Protection Agency 401 

## M Street SW 

## Washington DC 20460-0001 

## November 3, 1993 

## Attention Mr. Jim Tompkins RE: Worker Protection Standard 

## Final Labeling for: ETHREL brand Ethephon Plant Regulator for Pineapples and Sugarcane EPA REG

## No 264-257 PREP

## brand Ethephon for Cotton and Tobacco EPA REG No. 264-418


## Thank you for your prompt response for the above referenced labels. The proposed 

## changes have been made and final labeling is appended to document the changes. Please note on the PREP label there is a new_section that addresses the useofrecydable containers that was not in the original label 

# med as part of the WPS compliance. To 

## document that this wording has now been approved by 

## EPA we are appending the Agencies acceptance letter. If

## you have any questions please contact us promptly.



## Warren A. Davis Senior Registration Manager

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# 3

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--**------~** 

## -- -**~--~** - --- --- 

## -- --- 

## -- 

## -----------

Hr. Warren A. Davis Rhone-Poulenc Ag Company P.O. Box 12014, 2 T.W. Alexander Drive Research Triangle park, NC 27709 Dear Mr. Davis:

.., Subject: Returnable containers



# • PREP Ethephon Cotton Boll Opener EPA Registration No. 264-41B Your Submission Dated October 15, 1993 

## The amendment referred to above, sUbmitted in connection with 

## registration under the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA), as amended is acceptable provided that 

## you: 1. Make the labeling changes listed below before you release the product for shipment bearing the amended labeling: In the Environmental Hazard section delete "For terrestrial use,", Refer to PR Notice 93-8• 

## 2. Submit one (1) copy of your final printed labeling before you release the' product for shipment. A stamped copy of the labeling is enclosed for your records.

Enclosure Sincerely yours, 

# /cl, {**---~** 

## Cynthia G'les-Parker Product Manger (22) Fungicide Herbicide Branch Registration Division (H7505C)



# 4

# PREP TMBRAND ETHEPHON FOR COTTON AND TOBACCO
For Commercial Use Or Agricultural Use Only. Not For Residential Use ACTIVE INGREDIENT: Elhephon (2-Chloroethyl) phosphonic acid" "

...... »
.................. ,., .........................

### 55.4% 

### INERT INGREDIENTS:

........................................................................................................................... 44.6% ·This

### product contains 6 poundS ethephon percalion. 

### EPA Reg. No. 264·418 EPA 

## est. No. 264·PA·01 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO

# ~;;;;~;;;;;s;;;~;IOO~~'!'ii!ji!!I~!\!;l!~~!i;!l!:;i!iii [i USGS 

### ar.

# j~~~~~~~:~~:~~~a .18a and

# 4.:240..•19:. tlconso is gtantod to uso this product othor contomplated by this [abel. Liability lot paton! inltingoment may rosutl from us. or 

### ute of this 

# STATEMENT OF PRACTICAL TREATMENT IF IN EYES: Hold eyelids opon and ftush with a gantkl stroam of walor lot at least 15 mlnutos. Gol medical attontion, preferably on ophthalmologist. IF ON**SKJN~** Immediatoly wash skin with plenty 01 soap and water. 

### IF SWAllOWED: Do not induco vomiting. Promptly drinka largo quantity 01 milk. 

### egg whitoll:, glliatin solution or ifthosa ate not a

....ailablo, drink large quantilios ofwator. 

### AvoKl alcohol. 

### can a physician immodialely. 

### IF INHALED: Romove victim to Iresh air. 

### If nol breathing, give artificial respiratiOn. Administer oxygen if nGCGssary. Gol medical attantton. 

# PRECAUTIONARY STATEMEtlTS DANGER HAZARDS 

# ro HUMANS AND DOMESTIC ANIMALS

_ CORROSIVE. Causes eye

### and skin damago. 

### May bo lataJ if

### absorbed through skin. Harm:

..., 

### II swallowod or Inhaled. 

### Avoid broathlO9 

### pray mist. Do not got In oyes, on skin oron clothing. Koep

### aWlir{ from domosllC animals. OTE TO PHYSICIAN Thor. IS no spocific antidote. All Iroalmont should bo based on observod signs and symptoms of distross Intho patlont. OVGre)(posUie 10 materials othnrthan this product may havo occulted. Victims of sovero oVere)(posulo, by lnhalation, should bo kept under medical obsoJVation for up to 72 hours for dalayad onsat of pulmonary edama. In a victim 01 over-G)(posuro by ingestion, careful gastric lavage is required duo to Iho possibility of stomach or esophagoal perforation. This material is an acid, but uso 01 alkalino substancos to OQulratize it is rontraindfcaled. 

## PERSONAL PROTECTIVE EQUIPMENT (PPE) :•••:. Applicators and other handlers must woar rov.ralls over short·sk)ovod shirts and shorl pants. waterproof glo.Jas, chemical·rosistant footwear plus seeks, protective eyewear. chemical·resistant headgoar lor ovarhead exposuro and**chGmicar:r.pI~~,r:1** t'pIon whon cleaning ouipment. : •• :.: • Discard dothing and olhar absorbed matetialslhal have boon drenched or heavily contaminatedwilh-tlVs**product~** ronc..Tntrate. Do not rouse them. Follow manufacturer's instructiOn!> for ctaaning/maintaining PPE. II no such instru.alQQ$Jor washablos, use dot01:crt 

### and hoiwater. Kaop and wash PPEseparately trom athor laundry. : : Whon handlers use closed systems, onclosed cabs, or aircrafl in a manner thai moals tho

### requjrefTl~,n.tilist&d in:'tVl'

### :~n..tlr**Pr~t~.i,,}'l** Siandard (WPS) lor agncultural peslicidas [40 CFR 170.240 (d) 

### (4-6)1. Iho handler PPE requirement. may 

### be reduced or**modtft~** ..... specified in tha WPS. ..:..• •

should wash hands bafora aating, drinking, chewing gum, using tobacco or using the loilol. 

### • 

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## ENVIRONMENTAL HAZARDS Fot IOUGSlnal uses, do n01 apply diroclly 10 waler, orto amas whore suriaco walet IS crason! orto Intortldal aroas bolow tho moan high waist mark.. Do notconlammato WalGfwhon disposing of Gquipmontwashwstors. Do not contaminatewator usod lor irrigation ordomostlC purposes. 

## USE PRECAUTIONS 00 not apply PAEpm brand Elhophon through any typo of irrlgstion system. Avoid spray drlft 10 noarby crops as this product will causo modilications In plant growth. Plant Injury or reduced yiGlds wiH r"ult. 00 not plant anothor Crop wllhln 30 days after troatmont Mile only tho amounl ofspray you Ol(poctto uso oach day, 00 not allow mixod solutionto $land ovornight. 

# DIRECTIONS FOR USE It 

### I•• violation 01 

### Fode,al Law 

### to u•• thl. product In a mann., Inconsl.tonl with Ita 

### lab41llng. R.ad enttr. labal bofor. using thl. product. 00 not 

### apply this product in a way that will contact workors orothot porsons, Glthor dltectly or through drTtt, Only

### protGCteci handlers may be in tho area dUting application. For any requirements specific to your Stato or Ttibo. consult the 

### agoncy responsibla lor posticido rogulations.

# in~'iCOO~rd~;."'~C~.iW~'~"h~"'~':**~J:~""~ ~ng**  and with the Workor Protection Standard,

# 40 CFR part t70. This

# ~~~~~:~~~I . ot**wotko~** on farms, forosts, nutserles, and graanhousas, and handlers training, decontamination, notlflcatlon, and emergency assistanco. It also to the 5tatemants on this label about p1)rsonal protectIVe equipment (PPE),

requirements in this box only apply to uses 01 this product that ara coveted by tho 

### ·5 

# -. not enter orallow WOlker entry into treated areas dutingtho rostricWd-antry intervat (REI) 0148 hours.

required lor eatly ontry to treated aro

.. that Is pormitted under the Worker Prot&CIion Standard and that involve. contact that has be.., treatocl such as plarrts, soil or water is covOl'alis OVOI short-sloeved shfrt and short pants,**W'''.,p''''oI.Io~.',1** i footwear plus**~,** PfOtOC1ive oyowear umfc:hoinical·resiutant headgear tor ovorhoad oxposure, 

# STORAGE AND DISPOSAL I'T,ng""E 100 not contam; 1ato W' ,000t. food, ot food 

### by storage 1'( .:-,pos

..... container is

### b.::~;'" orcontents have 

### spilled, follow 

### all procautions indicated above and cIoan up immediately. Bofote c"O< ,.,;

on ful/length trousers, long sleoved shirt, protective glovos, and gogglos or faco shield, Soak up spill With absorbent meaia sand, earth orothor sUltabla material and dispose ot waste al an approved waste disposaltllcWty, OISPOSAL

# ,~!;~;;::w~as~Ji.~:'~'::'~.iac~~utely hazardous. Improper disposal of excess pesticide. spray mixtura, or nnsato is a violation of Fed.raJ law. 

### bedisposed of by use according to labol instructions, contact your Stato Pesticide or Environmentat

# Cont",,1

Waste rGprosontative attho noarest 

### EPA Regional 

### Office forguidanca. 

### CONTAINER DISPOSAL Triple rinse (or equivalent) the empty containers. Thon offor fot toeycUng or reconditioning, or puncture 

### and disposs 

### 01 in 

### a
... n"''Y1 landltll, orby inclnetation ot if allowed by stale and local authorities. by burning. If container is burned, stay out

# at**I~.** 

### RETURNABLE**~~** 

### REFILLABLE CONTAINERS • return tho container to the point 

# ,.til"''''''''P!**":::n~~~1** tor Cotton and 

### Tobacoo. DO In for damage such as ctacks,



## GENERAL INFORMATION COTTON 

### on II


## • • • ••••• • 

# . .. .. 

# . •••• A foliar sptay of PREPn. brand Ethophon will accelerato opening 01 mature unopened cotton bolls and**onhanca..d.I~I~Ior.** whict!

### c..
.. r r.sult in Garliet harvest with an rncrsasod roco-verabfa yield. PREPTW brand Ethophon troatmont on cotton ailOws"lttcMsod oHici."CO;' from a once-ovet harvest.


# 7

# -----------------

TOBACCO (FLUE-CURED): A loHar spray of PAEP"" brand Ethophon promotos early. uOiform "yGUowing· of mature tobacco. PAEPnI rMUCH cunng 11m•• allowing moro officium use 01 cunng Darn spaco, ana Incroased control ovor harvest schedulos. SPRAY PREPARATION Add 112

### to 3/401 tho r&quir&<:! amounl of wator to tho spray tank. Slart agitalion. Add tho roqwroo amount of PREpnI brand Elhophon, and tha romaining amount of water, PreparG only as much spray solution as can bo used on tho day 01 mixing. 00 not allow spray solution to stand ovornlght. Do not spill tho concentrated product on**~ray** OQUipment, or any airplano parts. 

### ANY SPILLS SHOULD BE RINSED IMMEDIATELYWfTH PLENTY OF WAlEA. Use 01 a nurso tank [s hlghlV recommonded lor avoiding possiblo spills of concontrated formulation on spray equipment or any airplane part.s. TANK MIXTURES WITH DEFOLIANTS AND INSECTICIDES PAEpnI brand Ethsphon is compatlblo with DEFt. FOLEX., Droppz, 

### Harvad.3

, Mothyl Parathion, GUlhion 1

, 

### and**MaJalhion~.** PAEpna may bo appllod in soquence or 

### as a tank mixlUro (DO NOT TANK MIX WITH DESICCANTS IF COrroN IS TO BE SPINDLE HARVESTED), Follow all appIicab14 U"o precautions and rate poraero recommondations on labofs of products applied 

### as tank mixtures orin sequonco with PREP 'nI brand Ethophon. In soma cases slight reduction in boll opening response has 

### baonobserved when tank mixes with deleliants WOte 

### used. Good agitalion in the 

### spray tank is essential and 

### a tank minura should not bo allowed to sland without agitation lormom Ihan 510 to minUlos, Road and ObsCHVO all appropriate Jabal use directions and procaubonsfor Iho dololianl$and insftdicido. used. NOTE: Under certain conditions, tank mixtures of PREPN brand Eth&phon with dosiccants containing sodium chlorate could rosult in tho lormation 01 hypochlorous acids which on hoatinqwi" omit toxicchloridelumes.



### ' UIPMENT CLEANING
cause ot tho 

### acidic natura 01 this product, prolonged exposuro 10 spray deposit will damage acrylic plastics. cerlain paints, and taJs. Ainu thoroughly with a detergent and wator all exposod acrylic plastic·typo matorials (o.g.• aircraftwindshiolds), and painted surfacos within an hour after exposure to spray dOpcnillS. At the end of e.en day, rinse thoroughly with a detergent and water aU tho motal parts of tho aircraft and tho 8s30cialod spray equipmont oxposad to tho spray dOp<)S!1s.



# •
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8**~-~--------------**



## COTTON

EXPECTED PREP"'" 

### ONE SPRAY VOLUME APPLfCATlON 

### USE CONDITIONS 

### RATE GALLON (Gals/A) TIMING 

### ::EE!T";; 

# iLBS**A~I~** 

### AI," PREPl\I 

### Hot and

### dry 800F or 

### 11/3 1.0 

# • Apply when Iho numb.r**~** 

### 8011 Oponer· higher 

### mature unopenod bolls.

### is: Dry and 75 to 8QeF 

### 2 1.5 4**15~50 2~5**  su/licionl to tho

### d""odo~oi**:"_below~**lor Coolbut aboVe 6Se F 

### 22/3**2~0** 3 tOSI 01 I 

### Treatment '

# open, Rank

# "".~n bolls 710 14 days o.vu8t. PREpno 

### + 

### High soil moisture 1/3**O~2S** 

### 24 15 ·50 5 - 10 

# i**;'lr.rp~**10 7 days

## prio~ 10 

## FOLEX* or boll j Dofal/ant 

### Tank High fertility lovol 

### To I

### U.~od~ Mix or 

### i

# ~ot**i~, ~~~lf:",**  

# W':i Rank ""rton I 

### Dropp2 High sort moisture 

### 1/3 

### 0.25 24 

# la-so 3

-

## to Apply <4 

### to 7 

### day. prior to Tank High lortility levol 

### PREpTW boll opening 

### MIX Rank cotton appHcation. To be used as 

### a**s~u;,=tr**

### •• lmont with, 

### not in of 

### PAEpno boll**Pr.~CQndUlon.r** Hot,dIY,:Wow80·F 

### 2/3**O~5** 

### 12 Apply 4 to 7 days prior to 

### '0' O.follatlon 0001, abovo.SS-F 

### 11/3 1.0 6 

### 15 -50**2~5** defoliant. 

### Enhance. 

### top crop d./oU.llon reducing 

### or deterioration of**bottom_:~** Rank cotton and allows for

-**~~~iiGr** 

### ·Pretreatment With Defoliants PrIor to PREpllI Boll Opening TI8aUJh

.... Illhecotton 

### :s ovarly r: lnkor Ityingdown 

### in Iha middles and good spray coverag. :)1 the bolls .vith PREPl\I is. difficult. a pratteatmMt with do#oHa;I.1 will b(II :.I40lull0hTlPlOVO boll coveraga with PAEpn.!. Use dosage rat'lS 01 PREpT'!brand Elhophon rocomn'end&d lor JOB opening. to...J ana ousorvG aU approprf3le label use dirodions and precautions 10' ·tho'del,:,';'nl used. oolf'! California andArlrona use 

### a volume of no loss Ihan 5 gaBons por aero lor aeria**,..~n:carions.** 

# AoIJ Maturity**~"** is malurewhen It IS 100 hatd 10 be donradwhon squo&zod oolWeen Ihumband lingo/"$, too hard to bosliced with a sharpknife, and when the seed COat bocomosUghl brown in color. 

### Use LImitations Do not QXcood II maximum of2.0 lb. aiJA for combined usos of PAEPTI<" por acre por yoar, 

### BoU Opening: Do not tank mix PAEpTI<" brand Ethophonwith a dosicc:lnl 

### ifthe cotton is to bo spindlo harvestlKi. Pr• ..condition lor Defoliation: Do not tank mil( PAE?m with dosiccants unlo8$. plant desiccation 

### is required. 

### 00 not use B defolianr beloro there IS sufficient mature unoponed boUs 10 produco tho dosired yiold ($90 Gonorallnlormation soc1ion on**h~** to losllorboll maturity. 

### !

..... WHEN TO HARVEST COTTON : •••

### !. Do not harvost cotton sooner Ihan 7 daysafter a trealmont with PREprw brand Elhophon. : ••:.: • 

### • 

## •• • Observothe trGated crop and harvosl whon optimum boll opening has been reachad. Too oarly harvbt**m~t** roduca Iho Iud advantlJqo 01 tho rrOalmenr and too laro III harvest may rosult in reduced quabty and loss of linrwhichwill drop**IrdI1'!)"'~lanl** 

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9PREpnI Crop SHuatlan Plnts/Acr.
Ol/octad Spray ApplicatIOn

DvM-Tho-Top Application

USE LIMITATIONS 1ti3

t 113-2213 

## so·so

4O-SO 

# TOBAcco (Flue-Cured Only)

Spacflfc Olractlona
Us. drop nozZlas, Chooso TG or DC spray tips dosigned 

### to • 60 

### 9pa at 35·40 psi and at tractor speed oj 2-3•.

# c,.. Us. 2 nozzles por row;one on each side oj tho rowdropped bw direct tho spray· to Iho loaves to be 

### ripenod and harvo$lod. 

### is Gssonlial. With a diroctod spray, 

### be sur. 10 harve.t I Troat only whon loav•• romaining on tho atalk are maturo. To 

### onlur. remaining faaves are mAturo, loat spray sovoral tobaec;o plants describod undertho aoction ·Propor Timo of Tr•• mont.· Usatho her in a normally mature cropwhon oJq)erionce indicates that minimum

### ~:~:~

# I
fnducomont is roquirDd. Uselho highor rat8 when the crop is heavy**~I** a tendency to bo mora rank or whon temperatures 

### are Iowar than Always 1851 spray to detormine 

### if Iho lobacco is malure onough

### to**';;;~nd**

# I 10 trealmant with PREf'lV brand Elhophon. Apply brand Elhephon spray as II line rnml nozzles (ono tha plan!:, and so aJl loavos are to tho



### 00nol apply PREpm

### brand Elhephon to immalura loaves 

### as this can result In unsalislactorycoloring, weight loss and reduced laaf quality, 

### 00 nol 

### allow tho Clop

### to ovorTlpen in Iho lillld atter usiog PREptW brand Elhophon, sinee this maycausasomo reduction in

### yit'ldand quality. 

### 00 nOI troal boloro anlicipatod major storm which could prev.tIt harvesl and rDsu/t in crop loss. Do not apply PREprw brand Elhopl'ion if rain is expectedwithln.4 hours. APPlIC.A":.v:: 

### TIMING SUCCCIssl',I rosults

## Wi h PREplW calf

### for Ireatmenl whon loaves are mature. nol overly rank groGn whon sprayed. To**'~asify** 0\0\1$.mine theplOJl'.r'traiiirriont jming and the number 01**~eavO$** por Stalk re:Jdy for harvest. lost spray sev.,..J plants In more th',n ono 

### !ccat 

### .:m in each**fW~** j an(t09s

....**~etho** response. Matwe'","lveswiI' 

### :'ogin to .,e!bwin

### 24 

### to 72 hours. Tost loavesthat lail

### to yelw'w in 

### 72 hOl". era not mat' re arv' aro not ready lor PREpn.c

... 4n

... Etha"hon troatmont. Wait ill low days to permit lurther natural mf:<JrinQ,**":~rt** make another.**~~** . _pray 

### or**~malurity·** checJo;, 

# t: YOU have conlirmed tho numbor01 leavos por plant that wiff color, you can dotormina Iho numbor 01 acros to Ireat in ordor to fiff 

### ,no ro your tosl spray 

### by mixing ono tonspoon 01 PREprw in t quan 01 wator. Spray oach lasl piant with about t oz. of this mixture. covoring 

### all /eaves with afino mist. PAEpnr brand Elhophon wiff nol colorimmature sprayed loaves. WHEN TO HARVEST 

### All maturo, sprayed loave. will begin to colorwithin 

### 24to 

### 72 hours alter PREpn.. brand Ethephon application, The yollowing prcx:eu is weatherdependant; cool weather WIll delay, while hoI. sunnywoalhercan 

### speed uptho 

### process. Harvesttreated tobacco when loaves havo raachad the dosirad color imons/[,(, 

### Do not allowtobacco to become ovor ripo bolore starling harvesl LaM dropcan OCCIJr when tobacco is ovar ripe 

### '\,nd 

### left on the stalk, If a numbor 01 tho bo«om leavos have yelloWed allho time of trealment, Ihey should be harvosted priorto spraying<WittJ. PREPrw brand Ethophon,

- 

### • • With 

### an over-Iho-.lop applicalion, harvosting can oommonco 

### 24 hours aftor PREpnr brand Elhephon app1i;4f#:ln doOiMitlO 

### on wutl)"r cooditions 

### orto avoid over ripo tobacco. Tobacco harvostod 

### 24 hours after treatmentwill require mont!lim, iQ Iheconr'llg**p~ase** o. Iho 

### curing process, - - CURING PREpn.c TREATED TOBACCO

..:--: 

### Curing proceduras are as much an art as a scmnco ana' oach cure must bo iudgod on tho basis of 10baOOQ.,COnditiar., :r.I.);'\'al bolv:ccr Iroalment and harvest, weather and type 

### of curing lacifity bolore prescriplion lemperaluro and.v.o.nailation**~Ies** can: l'r established. To obtain maximum quality, care must be takan to observe 

### end conlrol the curing procoss!cloSOIy, osre<;iallY during Ih'" lalo ·colorrng· 

### and early**·drying~** siagos 01 the IGaf. ••••• __. PREpn. brand Elhephon Iroaloo tobacco will have stattedtho coloring process when harvested, reducing thotime rooUlJed'in the coloring 

### phase 

### 01 curing, Treatoci tobacco should bo dried faster, tftobacco f9aves aro green oroontain some groen.wl.oll:larvos:t:=, 

### it may be necessarytocolor thorn lora

### few hours, fl the leaves atecompletely yollow. temperatura and vantijafion 

## rftw."bladjUSle'j in 

### a mannerto dry the lobacco 

### as last

### as possible wrthout scalding. Once tho loaf 

### is dried (314 dry), you should 10fJow 

### l'I,)rm-u rrocedUIllS lor curing. Since PREpn.c brand Ethophon troatoo leavss cure fastor, Ireated and untreatod loaves should not be cured togathor in tho same barn. 

# 10

# ,

LIMITED WARRANTY AND 

# DISCLAIMER Tho manufacturer warrants (a) that this productconforms to tho ci10mical doscriplion on tho tabol: (b) that this product 

### is roasonably lit fot tho purposes sol forth in Iho directions lot use when f1 is usGd in accordanco WIth such directions; and (c) that tho ditoctions, 

### warning and olhor statemonts on this label at. based upon tO$pOnsible experts' .",alualion of toasotlable tests 01 otfectivornlnl" 01 toxicity 10 laboratory animals and 

### to piants, and of residuos on food crops and upon reports offield experionco. Tosts have not boon 

### made on all vatietiGs

### at in all stales at undor all conditions. THE MANUFACTURER NEITHER MAKES NOR INTENDS. NOR DOES IT AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES. EXPRESS OR IMPLIED. AND IT 

### EXPRESSLY EXCLUDES ANO DISCLAIMS AlllMPUEO WARRANTIeS OF MERCHANT·ABILITYOR FITNESS FORAPARTICUlAR 

### PURPOSE. THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND ALL LOSS OR DAMAGE WHICH RESULTS FROM THE USE OF ntIS PRODUCT IN ANY MANNERWHICH IS INCONSISTENTWITH THE LABEL 

### OIRECTlONS. WARNINGS OR CAtJTlONS. BUYER'S EXCLUSIVE REMEDY AND 

### MANUFACTURER'S OR SElLER'S EXCLUSIVE LIABILITY FOR ANY AND All CLAIMS, LOSSES. DAMAGES, OR INJURIES RESULnNG

### FROMTHE USE 

### OR HANDUNG OFiHlS PRODUCT.

### WHETHER ORNOT BASED IN CONTRACT. NEGLIGENCE. SlRlCTLIABILITY IN TORT OROTHERWISE SHAll. BE UlAITED. ATTHE MANUFACTURER'S OPTlON. TO REPlACEMENTOF, ORTHE REPAVMENTOF THE PURCHASE PRICE FOR, THEOUANTTIYOF PROOUCTWITH RESPECTTO WHICH DAMAGES ARE CLAIMED, IN NO EVENT SHALL MANUFACTURER OR SEllER BE LIABLE FOR SPECIAL, INDIRECTOR CONSEQUENTIAl DAMAGES RESUL

### TJNG FROMTHE USE ORHANDLINGOFTHIS PRODUCT. NonCE 

### TO BUYER Purdlne ofthis product does not comOf' 

### any tights undor patlonts goyeming this product Ot tho use thoroo1 in countrlaa outsido of tho 

### United Statos.


### l,EFoOdG,'IWn ".<09

.. 

### '&<00 tradom""'" 0/ 

### 8ay.'

### AG, Go,mon,. lOropp IS a tegisteted tradomarkof 

### NOR-AM Chomical Company. 

### 3Harvada is a rogisteted tradomarkof Uniroyal Company.**~Malathion** 

### Is a trademark 

### of American Cyanamid Company

.


# •

Rh6no-Poulanc

### Ag 

### Company P.O. Box 

### 12014, 2 

### T.W. Aloxander 

### Drive Rosoatch Triangle Park, Not1h Carolina 

### 2n09 PREP is Iho tradomafi( of RMne-Poulorn:. FOLEX is a registered tradomark of Rhone·Poulenc

. PREPTIl brand Ethophon 

### for Colton and T obrux;o 

### (PENDING) Submittod 10ftS!93. 

### •••••• 

# . "


# ..

• •• 

## •••• 

# . , 

# .

" 

# .'



# ...

, , , 

# . •• ••• 

### , , 

# ....... ,

, 

# . ...

# ... .

, " 

### , ,

•

### ••• " 

# . ,

••••



# . , , 

## .,


# 11**f~**

# ~ RHONE-POULENC



# • AHONE.POULENC AG COMPANY 

### Effi93-30 

## November 3 ,1993
U. S. Environmental Protection Agency Office ofPesticide Program Document Processing Desk 

## Room 266 A, Crystal Mall No_ 2 1921 Jefferson Davis Highway Arlington, Virginia 22202 Allention: 

## Ms. Cynthia Giles-Parker 

## ProductManager (22) Fungicide Herbicide Branch Registration Division (H7505C)

Dear 

### Ms. Parker: 

## RE: PREP® Brand Ethephon For Cotton and Tobacco EPA 

## Reg_ No. 264-418 AppendedAs-..ftnal label

## f~""the above referenced product. The amendment approved added**r~ycla.1?!e::.d:mraTners** 

## to the directions for use. As 

## requested we have updated the label to include the mostTerrestrial statement required by PR notice 93-8. We appreciate your rapid approval for this label amendment. 

# • Sincerely, 

## /1/ /: /'

## ·t/fa.(~-. 

# #,£Q.( 'i\/arrcn 

## A Davis 

## Senior Registration Manager

?{) 2/,t**lc;)~4** 2PI. kJ:'-';,M,l""-'- '.;F'

## >" RfSI:'AJiCH14[i,.IC,'f PN> 

### r;c. ;,(Mi**19;Jj~Hj)20J0** if.fTEflxAL{)rMl 

## .t',

....,'**Hh\(~.** 

### !.<
__**~T** hl[RNfonONAL 'l'_, F. i.'**~"** li(Fi'**~·,,·!\i' "L·.,\\";r'''i<~**  M ,,'**'L~** 

### • • 

## •••••• • • 

## • •••••

## • • 

## • 

# .

,

# . • • ••• 

## • ••



# .

, 

# .

• •••••• 

# . ., • • •

### ••••• 

### • 

## •



# ., 

### ••••• • • 

# ...... • •

### ••••• • •



# ., • 

## •• •

### ••••• ,r,**).'L:e;rc.';CG",~'!P.<i;'i**_1.':-<**;~'.~** ••• ny-jc ':. ,i":'h':;'.e'ner1! 

# · .'.

-



### ••••



# 12

# •

• Mr. Warren A. Davis Rhone-Poulenc Ag company P.O. Box 12014, 2 T.W. Alexander Drive Research Triangle Park, Me 27709 Dear Mr. Davis: Subject: Returnable containers 

## PREP Ethephon Cotton Boll Opener EPA Registration No. 264-418 Your Submission Dated october 15, 1993 

## The amendment referred to above, submitted in connection 

## registration under the Federal Insecticide, Fungicide Rodenticide Act (FIFRA), as amended is acceptable provided 

## you: with and 

### that

1. 

### Hake the labeling changes listed below before you release 

### the product for shipment bearing the amended labeling: 

## In the Environmental Hazard section delete "For terrestrial use,lI. 

## Refer to 

## PR Notice 93-8. 2. Submit one (1) copy of your final printed labeling before you release the product for shipment. A stamped copy of the labeling is enclosed for your records.

Enclosure sincerely yours, 

# (s )
Cynthia

# G~eS-parker Product Manger (22) Fungicide Herbicide Branch Registration Division (H7505C)



# 13

### • 

## • TM 

# PREP BRAND ETHEPHON FOR conON AND TOBACCO
For Commercial Use Or Agricultural Use Only. Not For Residential Use ACTIVE INGREDIENt: Ethephon (2-Chloroethyl) 

### phosphonk: acId· .,......................................................55.4% INERT INGREDIENTS:

........................................................................................................................... 44.6% 

### "This product contains 6 pounds elhephon pergallon. 

# EN

___ O**EN~** 

# __**~** 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO**~Xf~iq"-** 

### a 

### usled ondelalla,

1·000-334-9745 

# us_ U.S. Patents 

# andt.:,4ii.811.: 

# ,,- to usa this product in counlrlos othorthan the orfor any

• use nol conlempJalod by thIs Slat85, Inlringoffionl may rosult from use or sale of thIs product outside tho UnitGd 

# STATEMENT OF PRACTICAL TREATMENT IFIN EVES: Hold oyolkfs open and lJush wkh a genUa slream ofwater for 311035115 minUI&s. Gel medical attention, preforably an ophthalmologist. IF ON SKIN: lmmltdJaloly wash skin with plonty 01 soap and water. IFSWALLOWED! Do not induCG vomhing. Promptly drink a largo quantijy of milk. 099 whites, golalin solution or ilthose are not aVailable, drink largo quanlill$$ 01 wator. Avoid alcohol. Call 

### a physician Immediatoly. IF INHALED: Removo victim to Irash aIr. II nof breathing, give artificial respiration. Administer oxygon 

### if necessary. Got msdicaJ allontion. 

# PRECAUTIONARY STATEMENTS DANGER .iAZARDS TO HUMANS AND DOMESTIC ANIMALS

_ CORROSIVE. Causes &ye 

### and skin damagG. May

### bofalallf absorbGd through skIn. 'Harmlul il swalJowod or Inhaled. Avoid breathing

• tpray mist. 

### 00nol got in oyes,

### on skin or onClO1hlng. Keep away from domesticanImals. 'NOTE TO PHYSICIAN

, There 

### Is no sp&cific antldoto. AU tmatmenlshould

### be basad on observ&d signs and symploms of distress in tho patient. OJorexposuro



### to matorials otherthan thIs product 

### may havo occurrod. Victims 01 savore overexposure, by Inhalation, should be kept under medical obsorvation lor up to 72 hours for dalayod onsot 01 ; pulmonary odoma. In a victim of ovor-i)xposuro by ingestion, careful gastric lavage 

### Is required due to the possibility 01 stomach or

, esophageal perforation. ThIs materIal Is an acid, but ose 01 alkalino subslaneGa to neutralize it is oonlraindicated.



## PERSONAL PROTECTIVE EQUIPMENT (PPE) Appllcalors and othar handlers must wear covoraUs ovsr short·swov&c! shlrls and short pants. watarprool gloves,**~!lPJT:~al.r~u.istant** lootwear plus socks. prot&clivo eyewear, ehomlcal·rosistan\ headgear for overhead exposuro and chomlcal-ros:stant apron when eloanlng eulpment.**~** , •••• DI,card clothIng and othor absorbed materials Ihat have boon drenched 

### or heavily contaminatod whh thIs products oo,lcantrate:

..

### {)o.**~** not reul8them. Follow manulacturer's inslructions 

### for cloaning/maintalning PPE. If nosuch instrudions for washablos(us& dotergLnt**~** and hot water. Koop and wash PPE separately from othor laundry. " •• Whon handlers useclosed sysloms, onclosed cabs, or ajrerait in a mannerthaf meels Ihe roqulrements listed In the Workor**Prot~Ii>!l. ~**  Siandard (WPS) lor agricultural pesticidos [40 CFR 170.240 (d) {4-6)J, Iho handler PPE requ!ramonls may be redui:eo'or.modilied 3l'1 spocilioo 

### fn the WP$. 

## r--------r=c::c;S-;;;j=-c.;====:::------,:-:-;---C.-,. User a ety Recommendations



## . I' Users should wash hands bolore eallng, drinking, chewIng gum, using tobacco or using tho loilot. R(lnlOV(l clolhi immediatel 

### if Gsticide ots Inside. Thon wash Ihoro hand ut on clean clothln

.


# 14 

# .;**-~-----------**

### EtNIRONM~TAL 

## HAZARDS
_ Fprferroslrlal usos, 0 

### not apply dlrl.lCt/y 10 water, orto areas where 3Urlaco wafer Is present or 10 Intot1ldal aroas below 

### tho mean high 

### viMoU'll.arlCDO- contaminate wat&r

### whon disposing 

### ofoquipmoot**~ashwalors.** Do notcontamlnatowator usod lor Irrigation or domostlc purposos, 

## USE PRECAUTIONS 00

### not apply PREpnI brond Ethophon through any Iypo 

### of Irrigation "ystom. Avoid spray drift 10 ".arb)' crops as Ihls product will cause mooiUcalions In plant growth. Plant Injury Of reduced yields will (&sullo 00 t\Ot plant anolhor cropwithin 30days after troatment. Mix only tho amount 01 spray you oXp&d.lo uSe oach day. Do not allow mixedsolution to stand ovornlght. 

# DIRECTIONS FOR USE It 18 

### a violalion of Fedetal 

### law to u•• this product In a mannor Incon81stent with Its lab.llng. 

### Road ontlr. labol balor. using fhl. product. Do nol apply Ihls 

### product In a way that will conlact workers or other persons. olther directly orthrough drift. Only protocted handlers may 

### be 

### in tho area during aPPlication. For any roquiroments specilic to your State or Tribe. consult tho agency rosponsiblo for p&$tlcido regulations.

'Use this product only In acoordatlce with Its labeling and with tho Walker Protection Startdard. 40

# ernpart 170. This standard lor the protection 01 agricultural wotkers on tarms, lorests, nurserios, and greenhouses, and handlers of i 

### k contains requirements for training, dooontaminalion, notHicallon. and emergency assistance. It also and expectations pertaining to tho statements on thi" label about personal protective equipment restrictod-entry intervals. The requirements In this box only apply to usos 01 this product that are 

## OO"

... ,iJ Standard. n01 onteror allowworker entry Into treated areas during the restricted-entry interval (REI) 0148 hours. for early ontry to treatod areas that is parmitted under the Worker Protection Standard and that Involves contact baen treated such as plants, soil or wator is coveralls over short-sleevod shirt and thort pants, watorprool 

### 910"'.1 tootwoar plus socks, protoctlvo eyewaar and chomlcal-rasl$tanl hoadgear lor o

....rhoad exposure. 

### I I

STORAGE ')0 not contaminate water, tood, ortud bystorago ordisposal. 

# I" container Is broken or contonts havo spiUod, lollow all precautions fndicatQd above and clean up Immediately. 80foro cleaning up,**~** out on fuiliongth trousers, long sleevod shirt, protecUve glovos, and gogglos or lace shlold. Soak up spill with absorbent media such

• 1$ sand, oarth oroilior suitable material and dispose 01 

### waste al an approved waste disposallacility. PESTICIDE DISPOSAL "\ Posticlde wastos are acutoly hazardous. Improperdisposal 01 GXCess pesticide, spray mixturo. or Iinsato Is aviolation 01 Fedorallaw, 

### Hthose wastos cannot 

### be disposed of 

### by use according 10 label instructions, contact your Stato Puticide or Environmental Control Agency orthe Hazardous Wasta represenlative at the nearost EPA Regional OIl1co lorguidance. CONTAtNER DISPOSAL Triple rlnso (or equivalent) the ompty container!;. Thon oller lor rocycling or rocondklonlng, or puncture and dispose olin a sanitary 

### IandtiR, or by Incineration or

### iI allowoo by stato and local authorllres, by burning. 

### Hcontainor Is hurned, stay out ot smok•. RETURNABLE

- REFILLABLE CONTAfNERS 

### Mat Ute, return tho containorto the point ofpurchase ordesignated locations, This contalnor must only bo rollflod 

### wLtI] PflEpnI

### tnt"d

, Ethaphon for Cotton and Tobacco. 

### 00 NOT REUSE THE CONTAINER FOR 

### ANY OTHER PURPOSE. Prior to roifll1ng, InipeCt

thoroughly for damago such as cracks, punctures, abrasions and damaged or

### worn out threads on closure devicos.' 

## Do not reflllJl1 transport damaged or laaklng containers, Check for leaks aftor refilling and betore transportation. For Information on {he disposal''li unused, unwanlod product. contact Ahlln&--Poulenc at f·800-334-9745. For informaHon on cklanup 

### ofspills, contact RMrIEl·PoulCU1.P**~t t·800·334~7577.**  "thocontalnor Is not bel refillod rotorn 

### it to tho int 01 urchaso.**.~.**'•

# .1**~** 

## GENERAL INFORMATION COTToN A 10Har spray of PREpw brand Ethophon will acc$lorato 0p$ning 01 maturo unopened collOn bolls and onhanco**doi(..l:aH~;;** which

# c3n': rosult in oarlier horvest 

### with an Increased r&COverablo yield. PREpni brand Ethophon treatm$nt on cotton allows incrlJascd etflclencY' Irom aonco-over harvaS!. • ."


# 15TOBACCO (FLUE-CURED): A 

### foliar spray 01 PREpllI brand Elhaphon promotos oarly, unllorm -yellowing* 01 maturo tobacco. 

### PREpm roduc&s curing limo, aUowfng moro ollicionl use 01 curing barn spaco,'and incrGasod control ovor halvost schodufos. 

### SPRAY PREPARATION 

### Add 112to 

### 314 of

### tho roquirod amount of 

### wahH 10 tho spray lank. Slart agilalion. Addtho requirod amount of PAEPnI brand Elhephon, and tho remainIng amount of walor. Propam only as much spray sclullon as can bo usod on tho day 01 mixing. 00 nol allow spray 1iOlution 10 stand ovornlght. 

### Do not spillihoconconlralod product on $pray oquipment, Ot any airplano parbt. 

### ANYSPillSSHOULD BE RINSED lMMEDIATELVWITH PLENTYOF

### WATER Uso of a nurso lank

### Is highly recommondod lor avokling possiblo splfls of conconlt81ed formulation on $pray oqu1pmonl or any airplano 

### parts. TANK MIXTURES WITH DEFOltANTS AND INSECTICIDES PREPn.: brand Elhephon Is compalible whh DEFt, FOLEX<II. Dropp2, Harvado3

, 

### Molhyl Parathion, Gulhlonr, 

### and Malathion". PAEpN may be applied In sequence or 

### as a lank mixlure (DO NOT 

### TANK MIX WITH DESICCANTS IF 

### conON IS TO BE SPINDLE HARVESTED). Follow all appllcablo use precautions and ralo poraero recommondations

## on labels of

### products 

### applied as tank mixlUros or 

### 10 sequence with PREP 'IV 

### brand Ethephon. In some cases slighl roduclion In 

### boll oponlng responSG has boen observed when lank mixes with delolianlswere usoo. Good agll:alion In Ihe spray tank is &ssonliaf and a lank mixture should nol be allowed 10 sland wjthoul agitation lormore than 

### 5 10 

### 10 minutes. Read and obsorve all appropriale Iabol use dlrodions and procaullons lorth13 dafollanls and InsGdicldes used.

.**~ ~OTE:**  

### Undercertain condttions, tank mixlures of PAEpN brand 

### Elhephon with deslccanls containing sodium chlorate could result in Ihe lormallon of hypochlorous acids which on hoatlng will 

### omilloxicchloride lumes. EQUIPMENT CLEANING

• Because 01 the acidic nalure of Ihis product, prolonged exposure 10 spray deposH will damago acrylic plastiCS, certain painlS, and motals.



# • Rinsa lhoroughly with a dolorgonl and 

### walor all oxposod acrylic plastlc·typo malerials (e.g" aircraftwindshields), and palnled surfacos within .n hour alier exposure 10 spray deposlls. At the end of each day, rinse Ihoroughly with a delorgonl and waler allihe molal parts of Ihe aircraft and Iho assoclalod spray oquipmonl oxpos9d 10 Iho spray doposils<



### AOCI!!"fIjD**_COM-~** 

### la 

### 11'/\ 

## Utter Dt,."j:

1**b,\~, l!"~**  

### l'vL, ,! 

### riY'llUlcWe .:

.. ;."**;~'1.!i:': .,~** ..**",~:;.\::: '~.ct** 



### , f- " :: ,- 

### t"**l.-'k:,~e** 

### '."'" fer;,'::).:'::-: 

## Nt}. 

# J.(rdl--=:.-!.! ( 

# R


# -**~~~ .~** ..

# ----------- 

# 16

# Ic6fi'l:iN
EXPECTED PREP'!'\< 

### ONE SPRAY VOLUME APPLICATION USE CONDITIONS RATE 

### GALLON {GalalA) 

### TIMING

# ~~HT":' PI, lDS A.!, A.,•• 

### AIr"" 

### PREpm Hot and dry

### tWFor 

### 11/3 1.0 

### 6 

### Apply woon tho**numb.r.f~** 

### Boll Opener· higher matura unoponed bolls sullielent 10 produco

## -~~~~ Dfy and

### 75 10 80°F 2 1.5 4 15 -SO 2·5 desired crop, Soo 

### below Coolbut abo

..." 65<;F 2213 2.0 3 1051 

# of boll

### m~;~IX~ Treatmont uniformly R.nk en,'::n 

### bolls 710 14 days oarfier. 

### PREprw + High soil moisture 

### ,/3 0.25 

### 2' 15

- 50 

### 5 -10 

### Apply 4 10 7

# da:0r.E;~ FOLEX* 

### 0' 

### PAEpTW. boll "elollan( Tank 

### High IArtility lovol application. To 

### bo**~_~s** 

### MIx 0' 

### a

# ~~U;I=**troaJmon£w~~** !

### Rank coNon 

### nol I I of PAEprn Dropp2 High soU moisluro 113 0.25 

### 2' 10

- 50 

### 3-10 

# I**App~** 4 10 7 day.

# "'~~~~ Defoliant Tank High 10rtUity lovol 

### boll openl 

### MIx Rank cotton 

### . To bous.

# ad. as

, a'

## ~i~,,~,~.trGa'mOnl with, 

# Inot

- of PREpni boll I 

### Pr.-Condltlon.r 

### Hot, dry. abovo 80 QF 

### 2/3 0.5 

### 12 Appty 4 to 7 days prior to 

### 10' Oefollatlon Cool, above**65~F** 

### 11/3 1.0 

### 6 15·50 

### 2-5 deloliant. Enhances top crop defoliation

### r.d~;'; 0' deterioration of bottom Rank colton and allows lor 

### ·Pretreatment With Defoliants PrIor to PREpn.! Boll OpenIng Trealment Htho colton Isoverly rank or laying down In tho mlddlea and good spray coverage of tha 

### bolls whh PAEpl'U 

### Is difficult. a protrealmont with dafollants will bo uselulto improve boU coverage with PREpni. Use do$age ratos 01 PREpni brand Elhophon recommended lorboll )poning. Road and observe all appropriate label use dlroctions andprocautions lortho dofoliant us&d. "In**Ca~fomia** and Arizona use a volume 01 no leM than 

### 5 gallons per acre for aorial applications

.



### • - '9011 Maturity A 

### bon Is malurewhen 

### it

### Is too hard 10 

### btl dented\\!hen SQuoozad botwoen thumb and lingers. too hard 10 bo slicedwl1h a sharp knifo, and when tho seed coal becomes lighl brown in color. 

### Use lImllatJons Do not eXCGOd a maximum 01 2.0 lb. altA forcombinod USGS of PAEpnt por acro par yoar. Boll OpGning: Do noltank mix PREpl'U brand Etlwphon whh a doslccant 

### if tho cotton is to 

### btl spindle harvosted. Pre-Condition lor Defoliation: Do nottank mix PREpm with desiccants vnlDss plant dosiccation Is requlrod. 

### Do not use a defoliant boloro thoro Is suHiciont matum unopenod bolls to producethe dosired yield (seo Genorallnlormatlon section on howto lost for 

### boll maturity. WHEN TO HARVEST COTTON 

### Do not harvost cotton soonerthan 7 days alter a troatment with PREpnt brand ElhOphon. 

# ...... Observe tho treatod crop and harvostwhon optimum OOllop&ning ha!!. boon reached. Too oarly harv&$t mighl reduce the}uU advantaiJ:l ofthe trea/mont and too late a harvost may result in reduced qualily and Ios5 of lint which will drop lrom 1he plant.

. . '



# 17... - - ---.. 

### -- 

## - 

# --------------

Crop


### DIrected Spray 

### Application

Applicalion PREplloI 

### Pinto/Aero
1 1/3



### 1 113- 22J3

USE LIMITATIONS 

### SO-50

40-60 

# TOBACCO (Flue-Cured Only)

Spoclflc Directions
Use drop nozztes. Chooso TG or OC spray lips designed to 

### apply 50 

### gpa al 35·40 psi and at traclor speed 01 2·3 mph. 2noulelPGfrow; one on oach side01 tho rowdroppod

# ~':!~:~~~:::!i::

# I
tho spray to tho loa.vas to be ripened and haN.sled. is Qssonttal. WlIh 

### a directed spray, 

### be sur. to harvosl
Troat only whon leaves remaining on tho stalk: are 

### remaining loavos ar. mature, lost spray soveral 

### doscribed undertho $oCllon ·ProperlimoofTreatment, In a normally malUfO cropwhon o)(porionce Indicates thai 

### tnducomonlls required. Usolho higherralo whon Iha 

## _··c- .:'C

..' a londoncy to be more rank or whon temperaturos are**~~:;:;;~~**

# I Always lost spray 10 deformlno 

### if tho tobacco is maturo o""",h " 

### 10 Ifoalmenl whh PREpm brand Elhophon, Apply ovor*lho-lop PAEptl.l brand Elhophon spray as a fino mist using oozztos (ono nozzle lips ovor tho centor of tho plant, and one on each so an leaves are coyorod , slmhar to tho I I



### Do nol 

### apply PAEPm brand Elhephon to Imrnaluro laaY05 as this can rosullin unsallslactory coloring, welghl loss and reduced leal qualily. 00 nol allow tho Cfopto ovor ripon In tho fiold allor using PREP"" brand Elhophon, sinco this may cause some roduction In yield and quality. 

### Do ooltreol bofofl) onlicipaled majorstorm which could pl'ovanl harvesl and result In crop loss. 

### Do nol 

### apply PAEp1lI brand Elhophon if ratn is oXPOClod within 4 hourn:. 

### APPLtCATION TIMING SlJCCOssfut results with**PAEP~** can for 

### Iraalmonl whon loa'.'o$ are moMe, 

### nol ovorly 

### rank groon whon sprayod. To easily dolarmino th. propertrealmentliming and tho numbor 01 loaves per stalk roady for harvost, tesl spray $evoral plants In more than ono location In each Hold and obssrvotho rosponso, Maturo loavo$ wlh begin to yellow In 241072 hours. Tesl loavssthllt fail 

### to yollow In 72 hours are \Ot mature 

### and are not roady lor PREP"" brand Ethephon trsalmon!. Wait a fow days to permit furlher natural maturing, then mako anothertosl spray or -malurity- chock,

- When 

### you have confirmod Iho numbar oll4av(Js por plamthat will color, you can dOlormlno tho numbar 01 aCr8! 10 Ireat In order to IIH

• • hebarn, Propar8 your lost spray by mixing OnG te-aspoon 01 PAEpllA In I quart 01 wator. Spray oach tost plant with aboul I oz. 01 this mixluro, covoring oll laavo& with afine mist. PREprM 

### brand Elhaphon wllt not

### colo! immaluro sprayod loavo!t 

### WHEN TO HARVEST AU maturo, sprayed loaves will bogtn 10 colorwimin 24 10 72 hours aftor PAEpl1.I brand Ethophon appHcaUon. Tho yellowing procoss 15 wootherdependont: cool woather wUl dolay. while hot, sunny weathorcan spooo up tho process, Harvosltroated lobaccowhon loavo$ have reached the dosired color intonsity. Do not allow tobacco to becomo ovor 

### ripe boloro starling haMSI. Leaf drop can occurwhen tobacco Is ovor ripe and lolt on the stalk. 

### Ha number 01 tho bottom loaves havo yotlowod at tho limo of tr8atmont, !hoy should be harvostod prior to spraying with PflEpmbrand Ethophon. Wilh an ovoHho·top applicalion. harvosling can commonco 24 hours altor PREpm brand Ethophon application depoorlln') on Wojiihor : con(mions orto avoid over ripo toboo:o, Tobacco harvested 24 hours rotor trealment wilt require more limo In tho co:Oring f.1hase 

### (A tho • curing procoss. CURING PREpw TREATED TOBACCO Curing procedule5 are 

### as much an art as 

### a science and aach cure must be judg&d on tho basis ollobaccoCClndition, irllGNaI**btJtwii~h'** • treatmenl and harvssl, woather and type 01 curing facility before prescripllon lemperalure and ventilation ,:.chtldules can' hijeslabllshed. To obtain maximum quanty, cara must bo laken to observe and CClntrol tho curing process closely, es'pe<:ialtf during th-a late -coloring- and early -drying" stagos of Iho loaf. •••••: PAEpm brand Ethephon troatod lobaccowitt have started Iho coloring 

### procoS$ when harvosted, rooucing the tlmo rO!:juirod In Ihe •• coloring phase 01 curing. Trealod tobacco should be dried laster. 

### Iftobacco leavos aro groon or conlain somo greon' lV'1grtnarvostM:**~:** 

### It may 

### be nacossary to color them for 

### a few hours. Iftho loavos are completely yellow, lemperature and ventitation musl oo,adjuSlbd iff' a manner 10 dry tho tobacco as last 

### aspossible whhout scalding, Once the Ioat Is dried (3/4 dry), you should foRow ('IQrD'faJjlrocedures lorcuring. Sinco PREpnr brand Ethephon treatoo loaves cure faster, lrealed and untreated loavos should oot bo cured togethor In tho samo barn, 

# 18 

# J

,**~-~---------**


# LIMITED WARRANTY AND DISCLAIMER Tho mantlfaClul0rwarrants (8) thai this

### product conforms to tho chomJcll1 description on tho 

### labol; (b) thallhls product 

### Is 

### 10asonably lit for 

### tho purposos sol forth In tho dlroctions /01 

### us. whon It 

### is usod In accordance with such dlroctlons; and (c) thai tho directions, warning and othor statemonts on this labol 8ro based upon rosponslblo exports' evaluation 01 roasonablo tesla of offoCi1'lonoss, of toxicity to laboratory animals and to plants. and ofrosldues on food crops and upon roports off10ld OXp61h)OOO, Tosls have nol boon 

### mado on altvarieties Of

### in all states or under aft conditions. THE MANUFACTURER NEITI-IER MAKES NOR INTENDS, NOR DOES IT 

### AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES. EXPRESS OR IMPLIED. AND IT EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIEDWARRANTIES OF MERCHANT-ABILITYOR FITNESS FCRAPARTICULAR PURPOSE. THIS WARRANTY DOES NOT EXTEND TO. AND TIlE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND All LOSS OR DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHKiH IS INCONSISTENTWITH 

### mE LABEL DIRECTIONS. WARNINGS ORCAUTIONS. BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SEllER'S EXCLUSIVE LlABlLlTY FOR ANY AND AU CLAIMS. lOSSES, DAMAGES, 

### OR INJURIES RESULTING 

### FROM THE USE 

### OR HANDLING 

### OF THIS PRODUCT. 

### WHETHER OR NOT 

### BASED IN CONTRACT. NEGLIGENCE. STRICT LIABILITY IN TORTOROTHERWISE SHAllBE LIMITED. AT THE MANUFACTIUREA'SOPTION. TC REPLACEMENTOF. ORTIlE REPAYMENTOF THE PURCHASE PRICE FOR. THE QUANTITYOF PRODUCTWITH RESPECTTO WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHAlL MANUFACTIURER OR SELLER BE LIABLE FOR SPECIAL. INDIRECTOR CONSEQUENTIALDAMAGES RESULTING FADMTHE USE OR HANDLINGOF THIS PRODUCT.

10TICE TO BUYER rurchasa 

### of this product dOGS not confer any rights under palionts governing Ihis product or tho use therool In countrios oUisklo 

### 01 the Unltod States. 

# e rDEF and Guthion ilro rC9lstorod tradomarks of BayorAG, Gurmany. 2Dropp 

### Is a rogistorod trademark

## at NOR·AM Chemical Company. 3Hruvade is a registoroo tradomalk 

### 01 Uniroyal Company.



# •4Malathion 

### Is atrademruk 

### o! Amoran Cyanamid Company

.

RhOne-Pouleoc 

### Ag Company P.O. Box 

### 12014, 2T.W. Alexandor Drivo Rosoarch Trianglta Park, North Carolina 

### 2n09 PREP Is tho trademark 01 Rh6ne·Poulonc. FOlEX Is a registered trademark of Rhllno·Poulenc

. PREpm brand Ethophon lor Colton and Tobacco (PENDING) Submkt&d 10/t5l93. .

# .....



# 19

# ETHEPHON FOR COTTON AND TOBACCO
For Commercial Use Or Agricultural Use Only. Not For Residential Use ACTIVE INGREDIENT: Ethephon (2..chloroethyJ) phosphonic acid·

H

......................................................

### 55.4% 

### INERT INGREDIENTS:

........................................................................................................................... 44.6% 

### -This product contains 6 pounds elheehon pergallon. EPA Reg. No. 264-418 

### EPA Est. No. 264·PA·Dl 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO

Sf uslod no &nilondo Ja .Ik·luola,**b~"1u. ,~~tg~i<,"**  

### p"aquo 

### t

# ~~~~~~~~~,-

For PRODUQI

# u.ss Information Call 1·800·334·9745
•he use 01 this product for a varioty of plant growth rGguJaUon USGS are protectod 

### by Unitod Stales and loroign palonls Including U,S, Patents 38,791.

## fsa and 4,240,819. No Jic&nse 

### is granted to use this product In counlnGs otherthan the United Stales or lor any use not contemplalad by this label. UabWty lor pah:mt**inJrmg&m~mt** may rasuk from usa or salo of this product outside the Unlted States• 

# • STATEMENT OF PRACTICAL TREATMENT tF tN 

### EYES: Hold eyelids opon and Hush with a gontlo stream 01 wator lor atlea5115 minutes. Get medical attention, prolerably an ophthalmologIst. tF ON SKJN: lmmodlatety wash skin with p!onty of soap and wetor. IF

### SWALLOWED: Do not Induce vomiting. Promptly drink a large quantity 01 milk, egg whllO$. gelatin sotution or Itthoso are not avaiJabIG. drink largo quantitios 01 water. 

### Avoid alcohol. Call

### a physIcian immediately. IF

### INHALED: Remove victim to tr9sh air. 

### Jt not breathIng, glvo artillclat respiration. Adminisler oxygen 

### if nGCGssary. Got modlcal attention. 

# PRECAUTIONARY STATEMENTS DANGER :iAZARDS TO HUMANS AND DOMESTIC ANIMALS CORROSIVE. Causos

### oyo and skln damago. May

### b& fatal ifablSotbOd through skin. Harmtul it swallowlKfor inhaled. AvoId breathing lp!ay mist. Do 001 got In eyes, on skin or on clothing, Keop away trom domestic anImals. 

### nOTE TO PHYStCIAN 

# tI

.. There is no specific antldote. All troatment should b& basod on obselVed signs and symptoms 01 distress in tho patlent. Qvaraxposuro ".,.."to materials other than 1hfs product may 

### hava occurrod. Victims of sovere overexposure. by Inhalation, should b& kopt under medical obsolVaUon tor up to 

### 72 hours tor delayed onsol 01 pulmonary edema. In a victim 01 over·exposure by Ingostion, careful gastric lavage 

### Is required due to the possIbility of stomach or esophageal p&r!oration. This matertatis an acid, but uso of alkaline substances to neutralize it is contraindicated. 

## PERSONAL PROTECTIVE EQUIPMENT (PPE) Applicators and othor handlers must wear coveralls ove.r short-sleeved shirts and short pants, waterproot**~Ioves, .::f1~.rr:.~I-resistant**  footwoor plus 

### socks, protective oyowear, chomlcal-rosutant hoadgoa.r tor overhead exposure and**chemIC8.1·res~stant** apron when cleanIng euipmonl. ,.**~. ~**  •- ; •. : Dtscard clolhing and other absorbOO matorials thet have bun drenchod or heavily contaminaled with Ihis

### product;'(X"l~ntratee 

## OQ • not reuse them. 

### Farlow manulacturer's InstrucHons for cleanlngfmaintaining PPE. 

### If no

### such inslructions lorwashabl&s:use**dete~tnt·:** and hot walor. Koop and wash PPE soparalely from other la.undry. '. •• When handlers use closed systems, onclosed cabs, oraircralt In a manner Ihat moets the requirements listed In

## th6~W~;ko·r**Prot;dl;'~~**- Standard 

### (WPS) lor agricultural pesllcides 

### 140 CFR f70.240 (d) 

### (4-6)}, the handlor PPE requiromonts may bo rodll!»d'ol';nodiJiod a; spocifiod In tho WPS. 

## User Safety Recommendations Users should wash hands beloro eating, drinking, chowing gum, using tobacco or using the tolkll. Remove clolhl immediate 

### if slicide ots Insido. Thon wash thorou hand ut on dean clothin


# 20- -- 

## ----**~~~-**


## ENVIRQ NTAL HAZARDS

- Fp(fettOSlrlal USGS, nol apply directlyto water, 

### orto aroas whore surface wator Is present orto Intertidal areas 

### bolow tho moan high 

### w1rtor.mruICOO (fo contaminato Walar

### whon disposing 01 equipment washwalots. 

### Do nol conlamlnalo walor usod for Irrigation ordomosllc purposos, 

## USE PRECAUTIONS Do not applv PAEprv brand Ethophon through 

### any typo of irrigation system. Avoid spray drifllo nearby crops as this product wiD causo modifications In plant growth. PlanllnJury 

### or reduced yields will result. Do not plant Gnother crop within 30days aftertIoatmonl. Mixonly 

### tho amount ofsprayyou oxpBCt 10 U$O each day. 00 not allow mixod solullon 10 stand ovornlght. 

# DIRECTIONS FOR USE It 

### Is a violation of Fed.ral 

### law to us. this product In a manner Incon81stent with Its 

### taballng. 

### Read entlr. lab.1 before using thl. product. Do nol apply this product in a way that 

### will contact workers orother porsons, either directly or through drift. Only protected handlers may be In the area during application. For any requirements specific to your State or Tribe,**oonsu~** the agency rosponsiblo 

### lor pesticide rogulatlons.

for tho protection 

### 01 agriculturat workers on farms. lorosts, nurserlos. and lusethis produd only In acoordance with Itslabalingand with tho Worker Protoction

# St~nd~'l'd~'~4~O~r~~~~~~~~:~~~~~~~1 It contains reqUIrements 

### for training. docontamlnation. notiticatlon. and and expectaUons pertaining to tho statements on this labol about parsonal and restricted-entry intervals. The raquiromonts in this box only 

### apply to uses 

### 01

Standard. (lOt ontor or allow worker entry into treated areas during the restricted-entry interval (REI) 

### 01 48 hours.

r&<lulred 

### lor ontry areas that is**porm~ted** under the Worker Protection Standard and that involves contact that hu as piants. soil 

### or wator is coveralls ovor short·sleelloo shirt and short pants, waterproof**g~,".",** socks, protectlve,oyewoar and**ch~micaf.res/stant** headgearfor overhead exposure,



### not contamlnato water, food, orteed by storage or disposal. 

### III container is broken or contents have spilled, follow all**pr~autions** indicated abovo and cloan up immodlatoly. Bolore

# cl"ao',,,,

- out on fuU kmgth trousers, long steoved shirt, prot.mive gloV08, and 909gl8$ or face shleld_ Soak up 

### spill with absorbent rs sand, earth or other suitable material and dispose ofwaste at an approved waste disposal facility. DISPOSAL**1P"~~lk;id"** wastes are acutely hazatdous. Impropor disposal 

### 01 oxcess pesticide, spray mixture, or rinnte is a violation 

### 01 Fodera! Ihese wastes cannot be disposed 

### 01 

### by use according to label instructions. contact your State Pesticide or Environmental

# CoO'""1**1~~~:i..;OI'~":h~G**Hazardous Waste roprosontativo at tho nearest EPA RGglonat Offica forguidanco. 

# It DtSPOSAL rinso (or oquivalent) tho empty containers. Than oller lor rocycting or roconditioning, or puncturo and dispose 

### 01 in a

# ,."h,oyl I or

### by inclnoratlon or If allowed 

### by stato and local authorities, 

### by burning. -H container Is burned. stay out

### 01 smoke. RETURNABLE •• REFILLABLE CONTAINERS US., return the container to the point ofpurchuoor deslgnatod tocations. This contalnor must only 

### berefilled**wttf1.P~EPn.(** for and Tobacco. DO NOT REUSE THE CONTAINER FOR ANY OTHER PURPOSE. PriOr t:l reflWng, for such as cracks, punctures, abrasions and damaged or worn out threads on closure devlcos.· containers. Chock for 

### ronks after rofilling and bofore transportation. For Information RhOne·PoulGnc 1-800-334-9745. For Information on cleanup of apHis, I 

## GENERAL INFORMATION COTTON 

### • •

A foliar spray

### 01 PREpw brand Ethephon 

### will accelerate opening 

### 01 mature unopenud cotton bolls and Gnhance dei<.J:a:bii which

## C3n' : result In earlier haMstwith an mcreased recoverable yiokL PAEpnf brand Ethophon troatment on cotton allows Increased olficl'oocY' lrom a onco-over harvosl. • ".


# 21TOBACCO (FlUE·CURED): A foliar spray 01 PAEpru brand Ethephon promotes andy. uniform "yollowing" 01 maturo tobacco, 

### PREpm foducas curing timo, allowing mora officionl USG 

### 01 curing barn spaco, and Increasod control ovor harvesl schodulos, 

### SPRAY PREPARATION Add 

### 11210314 

### oftho required amount of waler 10 tho spray tank. Start agkalion. Add tho required amount of 

### PREpN brand Ethophon, and tho romaining amount of water. Prepare only as much spray solution as clln be usod on tho day 01 mixing. 00 not allow spray 

### solullon 10 stand overnight. Do nol splilihoconcantratod product on sprayoquipmonl. Of any airplane parts. 

### ANYSPUSSHOULD BE RINSED IMMEDIATELYWITH PLENlYOFWATER Use of a nursetank 

### Is highly recommended for avoiding possiblo splits of concentrated formulatton on spray oqulpmanl or any airplane 

### parts. TANK MIXTURES WITH DEFOLIANTS AND INSECTICIDES PREpm brand Ethephon Is compatible with DEFt,**FOLEX~.** Dr0pp2, HalVada3

, Methyl Parathion, Guthion t

, and Malathion", PREP'Ilj may be 

### applied In sequence or as a tank mixture (DO NOT TANK MIX WITH DESICCANTS IF COTION IS TO BE SPINDLE HARVESTED). Foliow att applicable use precautions and rato

### poraere rocommondatlons on labels

### of products 

### awUod as lank mixtures or in saquence with PREP T!.I: brand Ethephon. In some casos sllghl roduction in 

### bolt oponlng response has baen observed when tank mixes with defoliants were us&d. 

### Good agitation in Ihe spray tank is essential and a tank mixture should not 

### be allowed to stand without agitation for more than 5to 10 minutes. Read and observe all appropriate labol use directions atJd precautions for tho defolianls and ins:ecticidos used. t{OTE: Und&r cortsln conditions, tank mixtures of PREP""' brand Ethephon with desiccants containing sodium chlorate could result In Ihe lormation of hypochlorous acid$ which on heating wltl emit toxic chloride lumes. EQUIPMENT CLEANING Because of tho acidic naturo 01 this product, prolonged exposure to spray deposit will damage acrylic plasticS, cenaln paints. and 

# t metals

.

• Rinse thoroughly with a detergent and water all oxposod acrylic ptastic·type materials (e.g., aircraft windshields), and painted surfaces wtlhln an hour after IIxposuna to spray deposits, At the end ot each day. rinse thoroughly with a dotorgent and wator all tho motal parfs of tho aircraft and the associatod spray oquipmont oxposed to tho spray doposils,



### A(X:ll1;"fliD**_COM~'f$** 

### 1a 

## IPA**lcu;~r Dtled~** 



# J0iJ

# ...:.:..-!L/ wl/C'----
__



# 22

# ICOTTON
EXPECTED PREp'll< 

### ONE SPRAY VOLUME APPLICATION USE CONDITIONS RATE 

### GALLON (GalafA) 

### TIMING 

### PREpm
PlnlaiA**I~~s** 

### A,I, Acro. 

### Air" PREptu Hot anddry SO>F 01' 

### I 

### 113 1.0 6 ApplV when tho number of 8011 Oponor* higher malure unoponod bolls [s 

### DIY and 75 to SO'F 

### 2 1,5 4 IS ·50 

### 2·5 sufficlont to produce tho doslr&d crop. See below for 

# I Cool 

### but above 

### nsoF 22/3 

### 2.0 3 tost of boll maturltv. 

### Troatment unilorm1v opons or bolls 710 14 daysoarll.r. 

# IRank COllon PREpn.! + 

### High soil moisture 

### 113 0.25 

### 2' lS·50 

### 5 ·10 

### Apply • 

### 10 7 days**p'lo~** 

### 10 

### FOLEX$ or**P!1_~PN** 

### boll I

......foll.nl 

### Tank High lar1l1ity loyol



### . To

# "'.u~"!h~ illx 

### 0' '

# ~~II~**pl~~I~t"~~E·~'**boti 

# IRank cotton 

# , PREPt'IoI+ 

# -' High soil moisture 

### 113 0,25 

### 2' 10-50 3 ·10 Apply 4 to 7 days prior 10 

### Tank High 

### fertility levol 

### PREp'lV boll**op~ning** 

### To be 

### uud an 'Mix Rank colton**~._** 

### Iraalmont with, 

### nOlln**pl~_.ol** 

### PREpm boll
Pr.·Condltlonot Hot, dry. above 

### BoeF 

### 213 0.5 12 Apply 4 to 7 days prior to 

### for O.folhltlon Cool, aboyo SS"F 

### 1113 1.0 6 t5-50 

### 2·5 dofoliant.

### Enhances-_~~~ or crop defoliation roducing deterioration 01 bottom crop Rank colton 

### .nd allows 

### 10' earllor 

### ·Protreatment Wl1h Oefollants Prior to PREprn Boll Opening Treatment If tho COlton 

### Is oyorly rank orlaying down in Iho mlddlo.and good 

### spraycovorage oltha bolls with PREpTW Is**djl1icu~,** a prelroatment with dololiants will 

### be usolul to Improve boll covorago wkh PAEPnt. Uso do$age rates of PREprn brand Ethephon rocornmandod lor boll 

### 1pGning. Road and obsorve aU appropriate labol use direclions and precaulionsfor tho dofollant used. Hln California and Arizona usa avolume 01 no less than 5 gallens pet aere fot aorial applicallons. 

### 'ioll Mafurlty Aboll 

### Is mature whon 

### it is foo hard 10 

### be donled whon squoezed between thumb and fingers, too hard to 

### be sHced wllh a sharp knifa, and .tWhenthe seed coat bocomes light brown in color. 

### Use 

### Limitations 00 not oxcaod a maximum of2.0 lb. aliA forcomblnod uses 01 PREP'" per aero por year. Boll Opening: 

### Do not tank mix PREptlol brand Elhophon with a desiccant 

### if Ihe cotton is to be spindle harvesled. Pro-Conclilion for Oeloll8tlon: Do not tank mix PREp-rtI with dosiccants unless plant desiccation is requir&d. 

### Do not use 8 dafoliant befora thoro is sulficient mature unoponod bolls to produce tha desired yreld (soo Ganerallnformation section on how to tosllor

### boil maturity. WHEN TO HARVEST COTTON 

### Do not harvest cotton soonorthan 7days aftar a treatmont with PREPN brand Ethophoo. ObsOI'YO tho traalGd crop and harvestwhon optimum boll opening has boon roached. Teo oarly harvest might reduco**th~fuH** adY8nta.J.» 01 tho ttoatment and too lato a harvest may rosultln rooucoc:l quality and loss 01 lintwhich will drop from tho plant. ,



# 23

# I 

# ---------------------

PREprn Crop Sfluallon 

### Plnta/Acr. A

... 

### Oirsctod Spray t tl3 50- 60 Application



### Over-Tho-Top 

### 1113-22/J 

### 40-60 AppUcalion



### USE LIMITATIONS 

# TOBACCO (Flue-Cured Only)

Spocl!lc 

### DIraclion.
Us. drop nozzlos, Choose TG or DC spray lips designed 

### to apply 50 • 60 

### gpa at 

### 35·40 psi and al tractor spoed of 2-3 mph. 

### Us. 2 nozzles por row; one on each sldo oftho rowdropped 

### lowenough 10 dll"$cl 

### tho spray to the loaves to bo riponod and hafVested. Thorough spray Is .ssentiat 

### With a diroctod spray. bo sure 10 harvesl aU loaves IWHh20%o< ; .



### Treal only when leaves remaining on Iho stalk afe maturo. To onsure 

### romainlng loaves are malur., losl spray sevoral tobacco plants as doscribed undorlhe $ocllon ·ProporTIme 01 Treatment." Use tho lower rale in a normally maturecropwhon experienco indical" thai minimum ripening 

### inducemont is 

### required. Use the higher rato when tho crop Is heavy and hll$ 

### a tendency to be more rank or whon temperatures aro lowor than normal. Always losl spray 10 

### dotormino iI 

### tho tobacco Is mature enough to respond to treatmanl with PREprw brand Ethephon. Apply over-the-top PREpn.I brand Ethephon spray aG 

### a fino mfsl using throe nozzles (ono nouletips over the center 01 

### the 

### plant, and 0110

### ~~l~~e~~O) so all loaves

### ~;~~~~[ed similar 10 

### the)

# Of!O to of 

### ,I**aa.nl~ ~** 

### sorav

Do not apply**PREP~** 

### brand Ethephon 10 

### ImmelUro loaves as lhis can rosuh In unsatislactoty coloring, woightloss and 

### reduced loaf quality. 

### 00 not 

### allow the crop to 

### over ripon in tho lield rutor using PREpTloI brand Ethophon. sinco this may cause some reduction In yield and quality. Do nottraat balore antlcipatod majorstorm which 

### could ptavont harvast and**resu~** 

### in crop loss.

o 

### 00not apply PREfn'4 brand Ethophon 

### if rain Is expectod within 

### 4 hours. APPLfCAnON 

### TIMING Succosswl resulls with PREpTloi call lor Iroalment whon leaves aro maluro, not ovorly rank groan whon sprayod. To easily dotarmlne tho proper traatmanttiming and Iho numbsr of leavos por stalk ready lor harvest, tast spray several planls In more than ono location In oach liold and obsefVothe response. Mature loaves will 

### begin to yollow in 24 

### to 72 

### hours. Test Ioavas that faU 

### to yoUow In 12

### hours are lot mature and are not raady lor PREpN brand Ethophon treatment. Wait a low days to parmillurthor natural maturing, thon make anolher losl spray or "maturity" check. 

# v
-, Whan you havo confirmod the numbor 01 

### leaves par plant that 

### will color, you can dalermlno the numbor of acros 10 

### lroalln ordor to 1m



### .he barn, Prapare your tasl spray by 

### mixing one teaspoon of PREpnl In t quart 01 

### Wator, Spray oach tost plant with about t oz, 01 

### this mixture,

• covering slil&avas with afino mist. PREfn'4 brand Ethophon will not color Immature sprayed leaves. WHEN TO 

### HARVEST All 

### mature, sprayed loaves will bogin to colorwithin 24 

### to 72 

### hours alter PREpN brand Ethaphon application. Tho 

### yellowing process Is weatherdBpGndenti cool wealhor will dolay, wllUG hot, sunnyweather can speod up th& procass. Harvost troatod lobaccowhen Ieavos have reached tho doslred color Intenslly, Do 

### not allow tobacco to oocoma ovsr ripe**bolof(~** 

### starting harvest leal drop can occur when tobacco 

### Is OVer ripe and loll on the slalk, If 

### a numberaltho bottom loavos have yeliowod althotime ollrealment, Ihey should be harvosted prior to spraying 'lfith PftEpn.! brand Ethaphon, Wllh an over·the-top application, harvesting can commenco 24 

### hours wter PAEpn.I brand Etllephon application deptll'lrlh,'J on wO\!lihq;' : conditions orto 

### avoid ovar rlp&tobacco. Tobacco harvestad 24 

### hours ahertrealmenl will requiro maro time In tho 

### co;orlnq phase ("f Ihe • curmg process, •**~** 

### •••• CURING PREpm TREATED TOBACCO 

### Curing procedures are 

### as much an art as 

### a science and each curo must be judged on the bas!s oltobncco condkion, ImerVal boIWei,th' • Ireatment and harvest, weather and type 01 

### curing lacility bolore proscrlpllon temperature and venlilation IIchE'dulo$ can' bi)" 

### established. To oblaln maximum qualily, care 

### must 

### be laken 10 

### obsorve and conlrallhe curing process closely, especlalf; during tha lalo ·colorlng- and oarly "drying- slages 01 

### tho !eaf. • "•• , •**PREP~** 

### brand Ethaphon traatod tobacco will hava started tho coloring procoss whon harvested, reducing the tima rO::lulroo In the coloring phase 01 

### curing. Trealed toboo:;o should be

### dried fastor, If

### tobacco loaves aregraan orcontain some graen l.y'wfbarveStlid; .: 

### it may be 

### nacassary to colerthom for atow hours, litho loaves are completely 

### YGlIow, temperature and ventilation must be.adJusIGd iff' 

### a mannorto drytho lobacco 

### aslast 

### as possible wkhout scalding. Once tho loal is 

### dried (3/4 

### dry), you should follow (!QI'Dla./Procoduros for curlng. Since PREpm brand Ethophon troated Ioavos curo faster, troatoo and untraated !Goave!; should nol 

### becured together 

### In tho sam. barn, 

# 24

### • 

# -------------------

LIMITED WARRANTY AND DISCLAIMER The rnMulacturorwarranls (a) that this 

### product conlorms totha chemical description on tho lab<.ll; (b) that this product 

### Is reasonably Ik 

### for the purposos sot fonh in tho directions for use whon 

### it Is usod in accordance with such diroctlons; and (e) thai the dir&Ctions, 

### warning and other statements on this label are based upon responsiblo experts' ovaluatlon of roasonablo tesls of effectiven"'ss. 01 taxlchy 10 laboratory animals and 10 plants. and 01 residues on food crops and upon reports oillo/d oxporlonc4. Tests have not boon 

### made on

## anvarieties or In all states or undor all conditions. THE MANUFACTURER NEITHER MAKES NOR INTENDS, NOR DOES IT AUTHORIZE ANY AGENT OR REPRESENTAnVE TO MAKE, ANY OTHER WARRANTIES, EXPRESS OR IMPLIED, AND IT EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANnES OF MERCHANT·ABILITYOR FflNESS FOR APARTICULAR 

## PURPOSE THiS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHAlL BE SOLELY RESPONSIBLE FOR. ANY AND All lOSS OR DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER

### WHJCH IS INCONSISTENTWITH 

### THE LABEL DIREClIDNS. WARNINGS 

### OR CAUTIONS. BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, LOSSES, DAMAGES, OR INJURIES RESUl 

### TIOO FROMTHE USE OR HANDLING OF THlS PRODUCT, 

### WHETHEROR NOT BASED 

### IN CONTRACT, NEGLIGENCE, STAICTLIABILITY IN TORTOR OTHERWISE SHALL BE LIMITED, ATTHE MANUFACTURER'S OPTION, TO REPLACEMENTOF, OR THE REPAYMENTOF THE PURCHASE PRICE FOR, THEOUANnTY OF PRODUCTWITH RESPECT TO WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, INDIRECT OR CONSEQUENTIAL DAMAGES RESULTING FROM THE USE DR HANDLINGOFTHIS PRODUCT.

tOnCE 

### TO BUYER ,-Iurchaso ofthis product does not canlor any rigllts undor pationts govornlng this product ortho use thereof In 

### CQUntnos outside 

### 01 the Unltod Slalas. 

# e 1DEF 

### and GUlhlon are rogl$lorod tradomarks 

### 01 BayerAG, Germany. 

### 2Dropp 

### is a rogistorad froo&mark of

### NOR·AM Chemical Company. 3Hruvado is 

### a reglstored tradomark

### 01 Uniroyal Company.



# •**~Malalhlon** is 

### a tradomark ofAmerican Cyanamid Company

.

Rh6no·PoulollC Ag 

### Company P.O. Box 

### 12014. 2 T.W. Alexander Drive Rosearch Ttianglo Park, North CaroNna. 27709 PREP Is Iho trademark 01 AhOne·Poulanc. FOLEX Is a rogistorod tradomark

### 01 RhOne-Poulone

. PREplW brand Elhophon 

### forCollon and Tobacco (PENDING) Submit16d 10/15/93. 

# 25

# -----------------
.?Jianrnd"n.troctlon$ on 

### rov.uo 

# ,""".



# . nURNn 

# '.30·" (Al Reglstrallon 

## jOPPi 

# , 

# &EPA Officoof 

# , 

# e::- Washington. DC 20460 

# I- Amendment 

# 196579 Application lor Pesticide: Other

# ~ It.

# Mi~~n

# -"-;0 /**;,~;;c** 3. 

# "CEPA 

# 2;;""t 

# W NOI1O 

# o ReMdctoo 4. ComponylF'roduct (Name) ,PM' 

## Micro Flo 

## I 8THEPHON 

### 6 

### 22

## ~ Applicant (If)(;/udo ZIP Coda) 

### 6.

. 

### 'n ,wkh F'FRA S,Clion3(c1l31 

### Micro Flo 

## Co. (b}{i). my product is similar or Idonlical in COfltposilion and labaling to: 

### P.O. 

## Box 5948 BREI! 

## Lakeland! FL 33807 EPA Rag. No. 

### 264-418 

# o Chock ifthis is a nowaddress Ptoduct M"

..... 

### PREP I

- Explain below Final p!intodJabals**~** 

## I- Agoncy kino! 

# -= in IOSponSO to Agoncy lo00r datOd
_______ 

# ? '1.10 Too'Application. 

# ,
- Explain below. Other· oxplnin oolow. Expfanallon: Uso additional pagels) it nQoossary. (For s&Cllon Iand Section II ) 

## Initial application 

## for ETH8PHON 

### 6 

### end use 

## product.

, III 

# It. 

# , , 

# , 

# "" , IUn, W

..

" 

# So""' 12**~i** 

# Byos' rYes 

### r- Yos 

### J

...,

# ~ No 

# t --2L P',,,,, No No _ Glass lOY

..: No. pur

# ~~~:~W9L No. per. 

# f.-- Papcr 

# , • CqrlffJcalkm musl

### bo w,l cOlllainor cootainor '-- OthOl" I 

# li-- Net COtlrontsln/OfJ1llJlion 

### 14_ 511:&(5) o\llelail 

# , 

# 5ao,'**O'.l~b"** i 

# o lab" 

## fX1

-- 1 2.5 gl 

## ,**"od,~'** I'M",,,," 

## VIh<"

# La"""""" 

# ex , D Othell 

### -.I



# -**rt.-~pOinl**

# ~.**~** Tolophono No. I 

# , MorTis 

## Gaskins of 

### Registrations (813)647"_3<308



## -

# - I' t amity Ihtlilhostatements I hal/o made on this lorm and all attachmonts ihorolo motrue, accuratB lIfldromp!"'\"}, 

# ., Iacknowledge thaiany knowingly lalso or misleading s!awmenl may bo ponishablo by lino Ofimprisonmontor ' 

# -**!~I!'!f1ped)** both IJfIdor applicable law.



# - .



## -

# -- -- 

## . 2.

# -Jv;~ 3. TiO,

. 

### t 

# fi../. "' '" 

### of Registrations 

# - 

# -- ., 

# -- -**~~~.**

# ~~Ga$kinS ,. D,,,**~~**

# ..

-

- February 1, 1994
,PA Fom 8570· (R",. "

... ) 

# .." Whil.

. EPA FU, Copy 

# , Y,lIow

# •

• UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON. D.C. 20460



## MEMORANDUM SUBJECI': Similarity ainie Determination for EPA

FROM: Reg. No. / File Symbol: 51036-ERI / Etheplwn 6


## Ian Blackwell, Biologist 

## Precautionary Review Section Registration Support Branch Registration Division (7505W)
TO: Cynthia Giles-Parker, PM 22 Fungicide-Herbicide Branch Registration Division (H7S05C) OFfICEOf PREVENTION.PESTICIOESANO TOlOC SUGSTNiC£S:



## PRS has reviewed the claim ofsimilarity and made the following decision regarding whether the EPA registered product(s) cited is similar:



## [.f] The suliject product is not similar to: Reg. no. 264-418, 264-276 or 51036-ERO

General Conunents: Reg. no. 264-418, 264-276 and 51036-ERO contain less Ethephon (active Ingredient) than51036-ERI. Theincrease inthepercentofEthephon may affect the acutetoxicity profile of51036-ERI by 

## Increasingitsoral and/orderrnai toxicity. This would 

## in turn call for a change in the precautionary statements.

NOTE: This memo pertains only to the decision concerning whether the 

## suliject product Is similar to the cited product(s) from an acute toxicological v1ewpolnt_ PRS bas not determined ifthe data base Is complete for the product(s) cited or If the precautionary labeling Is correct.

# ! L NOT P..J,",:\1IT;;,TZD 

## In Accordance "itt 

## i'R Notice 82-2, 

## • • TM 

# PREP BRAND Baeed 0'4 Draft Labelin. Dated 

## 10';;J.!i- 

# 'L'? 

# ETHEPHON FOR COTTON AND TOBACCO
For Commercial Use Or Agricultural Use Only. Not For Residential Use ACTIVE INGREDIENT: Efhephon**(2~Chloroelhyf)** 

### phosphonic acid·

.......................................................55.4% INERT INGREDIENTS: ......•................................................................................................................ 44.6% 'This product conlains 6 pounds elhephon por gallon. 

### EPA Rog. No. 264-418 EPA Es!. No. 254-PA-01 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO

Sr usted no entionde fa etiquota, busque a alguien para que so 

### Ia oXpHqUD 11 usted &n dolallo. (Ifyou do not understand 1M

### Jabal. find someone to explain 

### it to you in detail.) 

### For MEDICAL And TRANSPORTATION Emergencies ONLY Can 24 Hours A Day**1~800-33(.75n** 

### For 

## Y..S.&. Information Call**1-800·334~9745** Tho use of this product for a variety of plant groWlh regulation Uses are protectod by United States and foro n patents including U.S. Pat\'lnts 38,79t,188 and 4,240,819. No license is granted to use fhls product in countriesothor than the United Stilter; or for any not contemplated by Ihis label. Liabilily for patent intrlngement may result from use or sale of this product outside the United 

# STATEMENT OF PRACTICAL TREATMENT IF fN EYES: Hold eyalids open and flush with Ii gentle stream of water for 

### at least 15 minutes. Get medical attantion, proterably an ophthalmologisJ. fF ON SKIN: Immediately wash skin with plf1nty of soap and water. fF SWALLOWED: Do not induce vomiting. Promptly drink a large quantity of milk, 

### egg whites, gelatin solution or if those am not available, drink large quantities ofwater, Avoid alcohol. 

### Call a physician immediatoiy. fF INHALED: Remove victim to fresh air. Hnot breathing, give artificial respiration. Administer oxygen if necossary. Get modical attenlion. 

# PRECAUTIONARY STATEMENTS DANGER HAZARDS TO HUMANS AND DOMESTIC ANIMALS CORROSIVE. Causes eye and skin damage. 

### May bo fatal if absorbed through skin. Harmful if swallowed or inhaled. Avoid breathing

• pray mist. Do not got in ayes. on skin or on clothing. Keep away tram domestic animals. 

### WTE TO PHYSICIAN There is no 5pOCniC antidote. All treatment should be based on observed signs and symptoms of distress in the pation!. Overexposure to malarials othor than this product may have occurred. Victims of seveJQ ovoroxposuro, by ir'!halation, shOUld be kept under modical observation for up to 72 hours for defayed onset of pulmonary ooema, In a victim of over·ellposure by ingostion, caretul gastric lavago is required due to the possibility ot stomach or esophagoal perforation. This material is an add. but usa of alkaliM substances to neutralize it iscontraindicated. 

## PERSONAL PROTECTIVE EQUIPMENT (PPE) Applicators and othor handlers must wear coveralfs over short·sleoved shirts and short pants, waterproof gloves, chemical-resistant lootwear plus socks. protective oyewei1r. chomical-fOsiSlant headgear for**ov~rhead** OXPOSUfO and chemicaf·rosistant apron when cleaning oquipment or mixing and loading. Discard dothing and other absorbed materials that have been drenched or heavily contaminated wilh this

### produ£~~rtcentrato. Do not rouse them. Follow manufacturer's insfruclions for cleaning/maintaining PPE. If no such instructions for**wash~blos~** use**dot'1~;~'** and hot wator. Koep and wash PPE separately from othor laundry. : ••••• • • Whon handlors USQ closed systoms, onclosod cabs, or aircraU in it manner that moots the raquirements listed in

### th~**W~ri<&r Prore~k,p:**  Standard (WPS) for agricultural pesticides {40 CFR 170.240 (d) (4-6)J, tho handler PPE requirements may 

### be roducect or modifiod as specified in tho WPS. .:. ..:••• 

## User Safety Recommendations Users should wash hands before eating, drinking, chewing gum, using tobacco or usIng tho toilet. Remove clothina immediatelY [f oestlddo Qots insido. Then wash bodv thoroughlY and out on dean c\01hinQ. 

# - -- ,- 

# -

-

- 

# ..

- -

- ,



# - , 

# -

,

# -

# ..

28 •••••
•••• 

# -
- ,



# - •••• 

# - - 

# -- -

## ENVIRONMENTAL HAZARDS Do nOI apply directly 10 wator, or 10 areas whore surface water is present or to intertidal areas below the moan high water mark 00 nol contaminate waltH 

### when disposing of equipment washwators. 

### Do not contaminate wator usad for irrigation or domestic purposos. 

## USE PRECAUTIONS Do nol apply PAEP'n1 brand Elhophon throUgh any typo of irrigation system. Avoid spray drift to nearby crops as this product

### will cause modifications in plant growth. Plant injury or reduced yiolds will result. 00 nol plant another crop within 30days after Iroatman!. Mix only the amount of spray you oxpect to useeach day. 

### Do not allow mixed solution to siand overnight 

# DIRECTIONS FOR USE It 

### Is a violation of Foderal Law 

### to use this product In a manner Inconsistent with Ita labeling. Read entIre label before using this product. Do not apply this product in 

### a way that will contact workers orother persons, oither directly or through drift. Only protected handlers may be in the area during application. For any roquirements specific to your State or Tribe, consult the 

### agency responsible for pesticide regulations.

this product only in accordance with 

### its labeling and with the Worker Protection Standard, 

### 40 CFR part

# 170':11~?~[:~~~f~;~~!1**~:~EE;:11** for the protection of**a9ricu~ural** workers on farms, forests, nursaries, and**gnH~nhouses,** and 

### It contains reqUirements for training, decontamination, notification, and emergency assistance. It i and exceptions portaining to the slatements on this label about personal protective equipment workers and restricted-entry intervals. The roquiromenls in this box only apply to uses of this product that are

# cOv.,'''' Protection Standard. Do not entor or allow wOrker entry into troatod areas during the rostricted-ontry int$rval (REI) of 48 hours. PPE roquirod lor early entry to treated areas that is permitted**und~H** the Worker Protection Standard and thaf involves contact that has boen traatod such as plants, soil or wattar is coveralls over short-sleeved shirt and short pants, waterproof glovos, I

. footWear plus socks, protective Gyewear and chemicat·resistant headgear for overhead exposure. Ii I


# I."M''''E IDo 001 contaminate wator, lood. orteed by slorago or disposal. 

### II container is broken or contenls have- spitled, follow all precautions indicatoo above and clean up immediately, Before 

### de"o'ng on full length trousors, long sleQved shirl, protective gloves, and goggles or face- shield. Soak up spill with absorbent sand, earth orother suitable malOriat and dispose 01 waste at an approved waste disposal faclilty. D1SPOSAL 

# Ip,"ddl. wastes are acutely hazardous. Improper disposal of excess posticide, spray mixture, or rinsate 

### is a violation ot Federal law. wastos cannot 

### be disposed of by use according to labol inslructions, contact your Slate Pesticide or Environmental Control**~:~~AO::'~lt~h,~e** Hazardous Waste reprllSentative at tho nearest EPA Regional

# Office for guidance. D1SPOSAL {or equivalent} the empty conlainers, Than offer for rocycling or reconditioning, or puncture and dispose of in a sanitary

incineration or 

### if aHowed by stato and local authoriUes, by burning. If container is burned. stay out of smoke.

-- REFILLABLE CONTAINERS

, return the container to the point of purchase or designated locations. This container must only 

### be refilled with PREPl)'!

lor Cotton and Tobacco. 

### 00 NOT REUSE THE CONTAINER FOR ANY OTHER PURPOSE. Prio, to rlillilling, 

# '",p""1 lor damage such as cracks, punctures, abrasions and damaged or worn OUl threads on closure devitU,·'tTo not or leaking containers. Check for leaks after refilling and before transportation, For on' contact Ah6ne-Poukmc at1-S00-334-974S. For information on cleanup of '11 ,II 

## GENERAL INFORMATION • 

### ••• ••••• • • 

## ••••• COTTON •• :.: • 

### ••• ••• A loliar spray of PREpl!.l brand Ethephon will accelerale opening 01 mature unopened colton bolls and enhanco del6l1aJion whicll·oon • rosult in earlier harvest whh an increased rocovorabla yield. PREp!">! brand Ethephon treatmont on cotlon allows incro3ied elliciencY· Irom a once-over harvest. : ••• ••: ••: 

### •••• 

## •••• • • • •

•• 

## ••



# 29TOBACCO**{FLUE~CURED}:** A foHar spray of PREP'lA brand Ethephon promotes early, uniform**8yellowing~** of mature tobacco. PREPn; r(?duces curing time, allowing more officient use ofcuring barn spaco, and increased control ovor harvest schlKlules. 

### SPRAY PREPARATION Add 1/2 to 3/4 of the requlr&d amount 

### of walerto the spray tank, Start agitation. Add the required amount of PREPn! brand Ethephon. and the remaining amount of water, Prepare only as much spray solution as can 

### be used on the day of mixing. Do not allow spray solution to stand overnight. Do not spill thoconcentrated product on spray equipment. or any airplane paris. 

### ANYSPIllS SHOULD BE RINSED IMMEDIATElYWfTH PLENTY OF 

### WATER Use of a nurse tank Is highly recommended for avoiding possible spills 01 concentralod tormulation on spray equipmont orany airplane parts, 

### TANK MIXTURES WITH DEFOliANTS AND INSECTICIDES PREP1M brand Ethephon is compatible wilh DEF1,**FOlEX~,** Dropp2, Harvade3

. Methyl Parathion, Guthion1, and Malathion'!, PREpn, may be applie<l in soquence or as a tank mixture (DO NOT TANK MIX WITH DESfCCANTS IF 

### COnON IS 

### TO BE SPINDLE HARVESTED). Follow all applicable use precautions and rate per acro recommondations on labels of products applied as tank mixtures or in sequence with PREP nI brand Ethephon. In some cases slight re<luClion in boll opening rosponse has beon observed when tank mixes with defoliantswere used. Good agitation in the spray tank is essential and a tank mixture should not be allowed to stand without agi\aUon for more than 5 to 

### to m'lnUles, Read and obsoNe all appropriate label use direClions and precautions for the deloliants and insecticidos used. NOTE: Under certain conditions, tank mixtures of PREpl>! brand Ethephon with dosiccants containing sodium chlorato could result in the formation of hypochlorous acids which on heating will emit toxic chloride fumes. EQUIPMENT CLEANING 6eocause of tho acidic nature ot this product, prolonged oxposuro io spray doposit will damage acrylic plastics, certain paints. and "'etat5. Rinse thoroughly with a detergent and water all exposoo acrylic plastic·typa materials {e.g.• aircraft windshields}, and painted surfaces within an hour after exposure to spray deposits. At the and of .ach day, rinse thoroughly with a detergent and water all the metal parts of the aircraft and tho associated spray equipment oxposed to the spray deposits

.


# •

• • 

## •••••• • • • •••••• • • • 

# .. ,

• • ••• 

# · .,

., 

# . • 

# · 

# .. . , 

# . •••• • 

## • 

# · ., •••• 

# 30 •••••• 

# . ., • •


# .......

• •



# ., ••••• 

## • • ••••• • •••••• • •



# .,


# .

...**~**

# .

• • ••••

## COhON

EXPECTED PREP1"\! 

### ONE SPRAY VOLUME APPLICATION USE CONDITIONS 

### RATE GALLON (Gals/A) 

### TIMING PREpN
LBS A.1. 

### Acr•• 

## Iro, Air" PREPrv 

### Hot Mddry BOGF or I 113 1.0 

### 6 

### Apply when tho numbor of Bol! Opener· higher mature unopened bolls is Dry and 75 to 80 QF 2 1.5 4 15 -50 2·5 sufliciont 10 produce

### /~ro~ desired crop. Soo below Cool 

### but above 65 QF 2213 2.0 3 lesl of bol! maturity. 

### Treatmant unilormly opens 

### or bolls 710 14days earlior. 

# IRook coHoo PREp'!.! + High soil moisturo 113 

### 0.25 24 15-SO 5·10 Apply 4 10 7 days prior to 

### FOlEX* or PREPm boll opening Oofollanl 

### Tank High fertility level application. To be used as



### MIX a soquontla! trealment with, 

### or not

### j~-pl~o ,01 PREpn.l 

### boll 

# IRook coHon n;r-.,. Dfopp2 High soli moisture If3 0.25 24 10**~** 50 3- 10 Apply 4 10 7 days prior to DaleUanl Tank High 

### JoniJity level

### ~~~.~_~_ boll opening 

### Mix r To 

### be used as 

### Rank collon**~.:** Irealment with, 001 

# ;?**p1~",,_.01** PREpN boll
Pre-Conditioner**~,dry,above** 800F 2/3 0.5 

### 12 Apply 

### 4 to 

### 7 days prior to 

### lor Defoliation 

### Cool, above**65~F** I 113 1.0 

### 6 t5 ·50 2·5 defoliant. Enhances top


### or crop delolration reducing detorioration of bottom crop Rank cotlon 

### aod allows 

### let earlier 

### ·Pretreatment With Defoliants Prior to PREplM Boll 

### Opening Treatment II the cotton 

### is ovorly rank or laying down in the middles and good spray coverage of the 

### boUs with PREp1'loI 

### is difficult, D. protrcatmont with defoliants

### wi!! be useful to improvoboll coverage with PREpnt, Use dosage ratos of PREpOi brand Ethophon rocommended for bal!**o~ning.** Read and observo aU appropriato label use directions and precautionsfor the defoliant usod. "In Cali/ornla and Arizona use 

### a volume of no less than 

### 5 gallons per aero lor aerial applications. 

### _0Il 

### Maturity

...bollis mature when 

### it is too hard to bedentod when squeezed between thumb and lingers, too hard to be sliced with a sharp knife, and**wh~n** the soed coat becomes light brown in color. 

### Use Limitations Do not exceed 

### a maximum of 2.0 lb. ai/Afor combinG(! uses of PREpl" por acre por year. BoH Opening: 

### Do noltank mix PREPI)'! brand Ethaphon with a desiccant il the cotion is to bo spindle harvested. Pro-Condition lor Defoliation: Do not tank mix PREP'" with desiccants unless plant desiccation Is required. 

### Do not use a deloliant before thore is sufficiont mature unopened bolls to producetho dosired yield (sao General Information soction on howto test tor boll maturity. WHEN TO HARVEST COTTON 

### Do nOf harvest cotton soonor than 7 days aftor a treatmanl with PREP)'" brand Ethophon. 

### • 

## • •••••• ObsoNe the traated crop and harvesl whon optimum boll opening has been reached. Too early harvest might**rodu~e** the tull advtl'l.: of the treatment and too lata a harmst may result in reduced quality and loss of lint which 

### will drop lrom the plant : ••• :. • • 

### • 

## • • 

## •••

• • 

## ••• • 

## • 

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# .

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## • •



## •• ••••• 

## • • ••••• • 

## •••••• • •



# ., •••••• • • ••••PREpn. Crop Silualion Pfnta/Aer.
Directed Spray t t/3 Applicalion

Over·The-Top 

### 1 tl3

- 

### 2213 Application

USE LIMITATIONS 

# TOBACCO (Flue-Cured Only) 

# 8' Specific Directions
50-60

40-60 Use drop nozzfes_ Choose TG orOC spray tips designed to apply 50

. 60 gpa at 35-40 psi and at tractor speed of 2-3 mph. Use 2 nozzles PGr row; one on aach side of the row dropped 

### low enough to direct the to the loavos to be ripened and harvosfed. Thorough spray 

### cml.".& is essentiaL With a directed spray. I>e sure to harvest all leaves I

. Troat only whon lea'lOS remaining on the stalk are maturo. remaining leaves are mature, tast spray soveraf tobacco described underthe section ·ProperTtme 01 Treatment." Usa the in

# anormally mature crop when experience indicates that minimum

# r,,,,""" inducement is required. Use the higher rate when the 

### crop Is heavy a tendency to be more rank or whon temperatures are lower than I Always test spray to determine if the tobacco is mature enough to respond to treatment with PAEpm brand Ethephon. Apply over-the-top PAEpm brand Ethephon spray 

### as a fino mist using Ihr09 nozzlas (one nozzle tips overthe center 01 tho plant, and on each ' so all leaves are covered similar to the

Do not apply PREpn. brand Ethephon to immature IGaves 

### as this can result in unsatisfactory coloring, weight loss and reduced loat quality. 

### 00 not allow the crop to over ripen in tha field after using PREP'" brand Ethaphon, since this may causa some reduction in yield and quality. 

### Do not treat beforo anticipated major storm which could prevent harvest and result in crop loss. 

### 00 not apply**PREp1~** brand Ethephon if rain is oxpedOd w[thinA hours. APPLICATfON TIMING Successful results with**PREP1~** call for troatment when loaves are mature. not overly rank green when sprayed. To easily determine the piopertroatmont timing 

### and tho number of leaves p0r stalk ready for harvest, tO$t spray soveral plants in more than one location in each fiold and obs

.. 

### uve tho response. Mature loaV05 will bagin to yellOw in 24 to 72 hours. Test laav9s that fail to yellow In 72 hours are not mature and ar€l not ready for PREPn1 brand Ethephon treatment. Wait a tew days to parmit further natural maturing. thon make another tost spray or**~maturity"** check.

_ When you have conlirmed the number of leaves por plant that will color, you can dotermino the number of acros to treat in ordor to lill 

### o barn. ropare your tost spray by mixing one teaspoon of PREpl'l in 1 quart of wator. Spray oach test plant with about 1 oz. of this mixture, covering alileavas with a line mist.**PAEP!~** brand Ethophon will not color immature sprayed loaves. 

### WHEN TO HARVEST AI! malure, sprayed lGavGs will begin to color within 24 to 72 hours after PREpl'" brand Ethep!1on application. The yellowing process is woather dependent; cool weathor will delay, while hot. sunny weather (".an speed upthe process. Harvest treatoo tobacco when leaves have roached tho desired color intensity. Do not allow tobacco to become over ripe botore starting haNest. Loaf drop can occurwhen tobacco is over ripe and laft on thG stalk. If a numberof tho boltom leaves have yellowed at the timo of trealment, they should be harvosted prior to spraying with PAEPT"I brand Elhephon. With an over-the·top application, harvesting can commence 24 hours aftor PREptv brand Ethephon application depending on weathor conditions or to avoid ovor ripe tobacco. Tobacco harvested 24 hours after treatment will require more timo in the**~g69** phase of the curing process. - ___ --- 

## • • • CURING PREplM TREATED TOBACCO : ___:_ - - Curing prOCedures are as much an art as a sciencQ and each cure must be judged on the basis of tobacco conditi6n, interval bE!tt41M! lroatment and harvest, weather and typo of curing facililY boforo proscription tomperalura and ventilation sc:h-edulos can M established. To obtain maximum quality, care must be taken to obsarve and c:onlrol tho curing process closely, esPi!i.lly**duri"!J'~I!_** late**~coloring~** and early**~dryin9·** stages ot the leaf.

- _____ PREpI'M brand Ethephon treated tobacco will have started the coloring process when harvested, reducing thetime

### r9C{ui~n the

- coloring phase of curing. Treated tobacco should be dried faster. II tobacco leaves are green orcontain some groen**w~en harve:n~:-:**  it 

### may 

### be necessary 10 color thom for a lew hours. II the leaves am completely yellow, temperature andventilation must be adjusted ift

### n manner to dry the tobacco as fast as possible without scatding. Oncethe leaf is driGd (3/4 dry), you should follow t1lrq,'W**,.rocedti~-!** tor curing.**Sinc~** PREpn. brand Ethephon troated loaves cure faster, treatod and untroatod leaves should not be**curGt.l'·16~ether** 

### 1n>ttie"'- same barn.

- _ :



# -



# -_. 

# 32**r-------------------~-** 

# ....**~-** 

# ... --

LIMITED WARRANTY AND DISCLAIMER The manufacturer warrants (a) that this product conforms to Iho chemical doscription on tho label; (b) that this product is roasonably lit for the purposes sot forth in the directions for use whe-n 

### it is used in accordance with such directions; and (e) Ihal tho dirOClions. warning and other slalamonls on this labol arc based upon responsiblo experts' evaluation of reasonablo tosts of effoctivenoss, 01 toxicity to laboratory animals and to plants. and 01 residues on food crops and upon reports of !laid oxporienco. Tosls havo not boen made on all varietios or in allstalos or undorall conditions, THE MANUFACTURER NEITHER MAKES NOR INTENDS, NOR DOES IT AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE, ANY OTHER WARRANTIES, EXPRESS OR IMPLIED, AND IT EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANTIES OF MERCHANT·ABILITYOR FITNESS FOR A PARTICULAR PURPOSE. THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND ALL LOSS OR DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENTWITH THE LABEL DIRECTIONS, WARNINGS

### OR CAUTIONS. BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, LOSSES, DAMAGES, OR INJURIES RESUL

### TlOO FROM THE USE 

### OR HANDLING OF

### THIS PRODUCT, WHETHER 

### OR NOT BASED IN CONTRACT, NEGLIGENCE, STRICT LIABILITY IN TORT OR OltlERWISESHALL BE LIMITED, AT THE MANUFACTURER'S OPTION, TO REPLACEMENTOF, OR THE REPAYMENT 

### OFUIE PURCHASE PRICE FOR, ll-1E 

### QUANTITY OF PROOUCTWITH RESPECT TO WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, INDIRECT OR CONSEQUENTIAl DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT. NOTICE TO BUYER Purchase ofthis product does not confer any rights under palienls governing this product or the use theroof in countries outside 01 the United Slates.

--DEFand Guthion are registered trademarks ot Bayer AG, Germany. 2Dropp is a registored tradomark ot NOR·AM Chemical Campany. 3Harvado is a rogistorO(l trademark ot Uniroyal Company. 4Malathion is a trademark of Amadean Cyanamid Company

.


# •

RhOna·Poulonc Ag Company P.O. Box 12014, 2 T.W. Alaxander Drive Research Triangle Park, North Carolina 27709 PREP is the trademark 01 Rh6no·Poulonc. FOLEX is a registeroo trademark 01 Rhone-Poulonc. PREPTM brand Elhophon tor Cotton and Tobacco (MASTER) ApprOVild 10128193. 

### • 

## • •

### ••••• 

### • • • •••••• 

### • • 

# · •••



## •



# .... • 

## ••

•• • 

# · .. •• •

•

### ••• 

### • • 

# · .. •• 

## ••



# 33 •••••• • •• • • •••••• 

### • •



# .. ••••• 

## • • ••••• 

### •


# ......

• •



## ••



# .

# ..... • • •• ••

# • 

# •

• • Mr. Warren A. Davis Rhone-Poulenc Ag Company P.O. Box 12014, 

## 2 T.W. Alexander Drive Research Triangle Park, NC 27709 

## Dear Mr. Davis: Subject: Revised Basic Formula 

## PREP Ethephon cotton Boll Opener /' / EPA Registration No. 264-418**~** 

## Your Submission Dated August 18, 1993 The revised basic formula is in the files for this product. 

## accepted ones. acceptable and has been included It supersedes all previously


## "Sincerely yours I



## Cynthia Giles-Parker Product Manger (22) Fungicide Herbicide Branch Registration Division (7505C)



# 34

# • 

# •

• 

# • REG. NO:

# d (p

# 1.

-'1;p mE SYMBOL:

__ _

REVIEW FOR END USE PRODUCTS
TO: 

## FROM: PRODUcr CHEMISTRY
PM

## .;)~

# .~ 

# BLsfc" PRODUCT NAMES:

# Pree fi/a"f-

# f-eyyhfor~ Fw**{,~fI",**
THRU: 

# .**.Jl,_.fg.i.~.:!** 1-

# (V

CHEMICAL: •



# ------ MR1D NOS.

___________________ _ Food Use'

_______ _ 

## Non Food Use

_______ _ 

## Ineru cleared: c ()d () 

## e () yes () no () 

## lnens List 1 ( ) Other ( )
Please provide the 

### requested infonnation for 

## the following checked items:

1. 

# [1 Submit the product specific product chemistty data for your product. I I If 

## submined earlier. provide MR1D Nwnber(s). I I Your product is not sufficiently similar to 

## the product your referenced.


## 2. In 

## ",Celencc to the 

## Confidential Statement of Fonnula (CSP). please provide the foUowing: 

# [1 a) pH of product at 

## a specified water dilution. 

# [1 b) Density 

## ofproduct. 

# [ 1 c) Fluh 

## point ofproduct.



# [1 d) FI&IIl 

## point ofproduct with propellent as 

## per item #6(q) or item #5(c). [1 

## e) Flash extension of product including flashbacks if

## noted. 

# y/.....**~/fov** I}

# -:b/~**~.~ ~** **(~tJ.-?~'1-SI1** "
i 

### •



# 35

## -2-

[] t) 

## TIle upper 

## and lower certified 

## limits based on the pure active ingredientS rather 

## than the technical or concentrate. 

### [J 

### g) The 

### upper and lower <:<rrified limits of the individually added inens. 

# [J h) 

### [J i) 

### [J j)


### 3. Based on the 

### current CSF 

### dated • your product 

## will not mee' the 

### label claim for 

## the active ingredient. Please revise 

## the label or 

## the CSF so 

## that the information 

## agrees. 

# e

4. Provide the chemical identify of all components. the percentage composlllon. CAS • Registry Number. and Material Safety Data Sheet (two copiea) for the following 

## compounds:
I. 

## 2.
3.
4.
5.

The 

### supplier may contact 

### EPA directly**~ferencing** 

### the 

### Pile Symbol of EPA Registtation Number 

## in their 

### response. Por dyea. provide the oolor 

### index and CAS Registry Numbers for all components. Por perfumes and flavorings. provided 

### for each component in the mixtwe: the 

### cber:nicol 

# =. CAS Registry Number. and the 

### percentage or 

# ranae in percentage in the mixtwe. 

### Certify 

## tha< flavors are non-food type. 

## Tho C""fidential infomution submirted by the 

### suppliers 

## is 

## kept oonfidential Wlder FIPRA Section 10.
5. 

## In the 

### proposed' labeling. provide the following infomution: 

# [J a) Update the 

### label Storage and Peaticide and Container DispoIal Statements in 

### accordance 

## with [ 

## JPR Notice 84-1 for non-aerosol cootainers for houses 

### and institutional ..." of [ 

# JPR Notice 83-3 for all other woes.



# 36 

# • 

# •

# • 

# •

• • -3- [J b) Add the heading PHYSICAL OR CHEMICAL HAZARDS to the label and the appropriate statement per 40 CFR 156.10(h)(2)(ili). [J 

### c) Under the heading PHYSICAL OR CHEMICAL HAZARDS, list the product as extremely Aammable (because **your** 

### product contains flammable 

## propellents). [) d) Provide 

## that the solvent does not have 

## insecticidal activity, it 

### should 

## be removed from the ingredient statement active ingredient 

## listing and 

## the percentage added 10 

### the inert ingredients. If 

### the solvent bas insecticidal -propenies, provide the EPA Registration Number. 

# [J e) Add. footnote to the inert ingredients indicating: Contains

(] t) 

### Since your data 

### matrix does not provide a dielectrical breakdown voltage, you 

## must add 

## the following statement to the physical or Chemical Hazards heading;


## Do not use this 

## product in 

## or on electrical equipment due to the possibility 

### of shock 

### hazard. 

# [J g) 

### The terms active ingredient(s) and inert ingredients should he in the same type 

### size, he 

## aligned to the same margin and be 

### equally 

### prominent. 

## [1 h) 

# [1 i)


### 6. 

## In reference to the product spocific data requirements, 

## provide the following 

### infoanation: [J a) Statement of Composition: A complete description of the manufacturing fonnIJlation 

## process. 

## Describe equipment used, 1l1ixJng time, temperature, pressure, etc. 

### [J b) 

### DilIctwion ofFonnation ofUnintentional lngrediento: A brief description of impurities formed dnring the manufacturinglfortnulation process, inpackaging 

## or during 

## storage. If

## you do not expect any impurities during 

## these stages, please so state. [1 c) Certification of Limits: Upper and lower 

### lintits or each active and 

## individually 

## added. inert component.



# 37

## [1 d) Analytical Method: Provide the methods used to analyze 

### for the 

### active ingredients or a full 

### reference for a published method or MRID Nwnber(s) 

# [J e) Color: In 

### conunon ICons. 

# [J f) 

### Physical State: e.g
.. solid. liquid. pressurized liquid. etc. (J g) 

### Odor: In 

### common terms 

# [J h) Density: e.g
.. lbs/gallon for liquids or lbs/cu.ft for solids. 

# [ 1 i) Ph: 

### Provide 

## pH of product or 

## pH of a 

### specified water 

### dilution, [ ) 

## j) Oxidizing 

## or Reducing Action: Note these characteristics. if any. [ ) 

## k) Explodability: Note these characteristics. ifany. 

## [ 

## ) 1) 

### Viscosity: Can be 

### expressed in 

### centipoise or centistoke. 

# [J m) 

### Miscibility: Note these charactedstics if

### product is an 

### emulsifiable 

## liquid aod 

### mixed with 

## oil. [J n) Corrosion Charac1eri8tics: This 

### infonruttion can be 

### noted during !he 

### storage stability 

## stUdy. 

# [1 0) 

## [1 p) 

### Dielectric 

## Breakdown Voltage: For products 

## used oeor electrical equipment. Storage Srability: 

## The formulated product inoo be 

### analyzed 

### for its 

### active ingredients at 

## time :zero aod 

### during 

### one 

## yeat ofstorage. 

## The storage should 

# • 

# •

be 

### at

# w_ conditions of temperature aod bumidity 

## aDd 

## IIIored in!he • 

### product" 

## commetciaI 

## package. Note: 

## For the 

## storage stability stUdy, 

### you 

## may not 

## reference the 

### data 

## on source product concemrare 

## you are using to 

# e formulate your 

### product. [1 q) 

### P1ammability: P1aah point/flame extension. 

## The flaah point reponed exceeds 

### the 

## one expected for this 

### product. PIe... check 

## aDd 

## resubmit. Mixtures marketed 

## under preas""', including !hose 

### containing hydrocarbons, 

### are subject in 

### their entiIety 

### to tests indicated in 

### 40 CPR Section 1S6.1O(bX2)(ili) ofthe maxipackag.. 

### Note that 

### flash pomts for pressuri=d 

## liquid from !he 

### container [1 

### Ifany of

### the items are not applicable, write N.A. and explain IUSons 

### are specified under chemistry data requirements footnotes. See 40 CPR Pan 

## IS8.



# 38**~.------**

### ---.-..

### -

...

# -

..

### -

....- .. 

### -



# • 

# •

• 

# • -5-
7. 

# [1 The 

### following is 

### the regulatory stalUs of the inert ingredients under 4Q 

### CFR 

## 180.1001 for for the exemption of the requirement of a 

## tolerance.


## 8. Other



## Note to PM; lnter-<>ffice use only

SUMMARY ATTACHED



# 39

# • 

# •

• 

# • I I 

# I 

# I TAlILBi 1:**S~** 

# or PRODUCT**CHBMIS~ DA~A**  

## RBQUIRZMBNTS



# ""'. I "",.. 

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### au. lfot Aflpl.l.Hl>l. .t."'1:1

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### O.t.,



# 40• <. 

### OF BARCODE: 0194604
CASE: 003396 

### SUBMISSION: S446994 

### DATA PACKAGE RECORD BEAN SHEET 

# * * * CASE/SUBMISSION INFORMATION 

## * 

## * * DATE: 08/31/93 Page 1 of 1



### CASE TYPE: REGISTRATION CHEMICALS: 099801 Ethephon ACTION: 345 TECH-FORMULA CHANGE AMND 

### 55.4000% ID,: 000264-00418 PREP PLANT REGULATOR COMPANY: 000264 RHONE-POULENC AG COMPANY 

### PRODUCT HANMER: 22 CYNTHIA GILES-PARKER PH TEAH REVIEWER: JAHES STONE RECEIVED DATE: 08/26/93 DUE OUT DATE: FOR COTTON 

### 703-305-5540 703-305-7391 

### 11/24/93 

# * 

# * * DATA PACKAGE INFORMATION 

# * * *
DP BARCODE: 

### 194604 EXPEDITE: N 

### DATE SENT: 

### 08/31/93 

### 4IHEMICAL: 099801 Ethephon p 

### TYPE: 001 submission Related Data Package 

## _SIGNED TO CSF: Y LABEL: 

### N 

## DATE IN DATE 

### OUT ADMIN DUE 

## DIV : 

### RD 

### / / / / NEGOT 

### 8RAN: RSB 

## / / 

## / / PROJ SECT: PCRS 

### / 

## I I I REVR : 

### / / / / CONTR: 

### / I 

## / 

## / 

# * * 

# * DATA REVIEW INSTRUCTIONS 

## * * *
Review revised basic formula 

# * * * DATA PACKAGE EVALUATION 

# * * *
No evaluation is written for this data package. 

### ROOH: CH2 ROOH: CM2

DATE RET.: 

### /

DATE: 10/15/93 DATE: 10/15/93 DATE: 

## I I



# * * * ADDITIONAL DATA PACKAGES FOR THIS SUBMISSION 

# * * * BRANCHjSEC'rrON 

### DATE OUT 

### DUE BACK INS CSF



# 41 229 247



### /

LA8EL

# ~j {Il/\

# ~~~~~~~~~=,-,-=-=~==~-==-~



# • •

•

• RHONE·POUlENC AG COMPANY 

### ETH93·24 

## August 18,1993


## U. S. Environmental Protection Agency OfficeofPesticide Program Document Processing Desk 

## Room 266 

## A, CrystalMall No.2 

## 1921 Jefferson DavisHighway Arlington, Virginia 

## =02 Attention: Ms. Cynthia**Giles~Parker** 

## ProductManager (22) 

## FungicideHerbicide Brandl RegisLTation Division (H7505C)



## DearMs. Parker:
RE: PREP® Brand Ethephon Cotton Boll Opener EPA Reg. No. 264·418 On 

## May24,1993 you advised us thata source ofsupply for the basicformulalion for PREP® Brand EthephonCotton Boll Openershouldbeidenlified. Please be 

## advised thatthesourceof supplyis Base 250 (EPA Reg No. 264-511) the sameas for the currentalternatefonnulalionon 

## file with EPA A 

## new umfidenlial statementoffOflnulation 

## is appended to identifythe source 

## ofsupply. With theexception of theadditionoftheregislration numberfor Base250 inblock 12 lhereare

## nootherchangesfrom 

## theformulation statementfiled on 

## January 1, 1993. 

## Ifyou 

## have any 

## addilional qUL'Slions pleasecontact 

## meprompUy. 

## We appreciateyour assistance

.

Sincerely,

/ / /)

### {~{>a~L0~ 

# If /'/;7)(.-,,",- 

## Warren A. 

## Davis Senior

## Registration Manager 

## • 

# ... • •• • • 

## ••



# .

, 

# .

• 

## •• 

## • 

# ., 

# . • ••



## •• •• 

### • ••

• • • 

## • •• •••••• 

## • •• 

## • • 

## •••••• 

## • •



## •• •

### •••• · 

# . ••• •• 

## • • ••••• 

### • 

## •

•


# ... ...... f>,:>eox t:!C11 :: 1'N.f,t FlN,;:'U1 ()">;i'**R~SFJ\G-C"** lIl!ANGl to ;"NH**~,c** 2lTV] 01,))"",10·2(06**~~Cejj[Jnceilr** 

### Pcriortulf¥'x· 

### • 

## • P

### rt!.,r.**~\~,ct1ii:;**

### vpmcr1\ It,TfTi',ATlonAL TLi"X i-FJI,t,.'V-l .t;,:!,jji!; "',$'1,'FR2N.::'" /-r< fd" 1';n::rhATlGt:'\i tw:;-:nUV,Ul**S~i),\'IC**fS if! [j ',,-,v:c.mn'J'n;" l,t':;I',tPP/·C"; 1'.".:: !;', J 

# 42

# l •• 

# PREp TM

# BRAND ETHEPHON FOR COTTON AND TOBACCO
For Commercial Use 

## Or Agricultural Use Only. Not For Residential Use ACTIVE INGREDIENT: Ethephon (2-Chloroethyl) phosphonlc acid-

................................."

....................

### ,55.4% INERT INGREDIENTS:

........................................................................................................................... 44.6% -This

## product conlains 6 pounds elhephon per gallon. 

### EPA Rog. No. 264-418 EPA Est. No. 264·PA·01 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO

STATEMENT OF PRACTICAL TREATMENT IF IN EYES: Hold eyelids open and flush whh agentle stream 01 water 

### lot 

### at loast 15 minutos. Get 

### medical atlantion, preferably an 

### ophlholmoJogist. IF ON**SKlN~** Immediately wash skin with plenty 01 soap and water. IFSWALLOWED: 

### Do notjnrluco vomiting. Promptly drink a large qu

..ntity 

### of milk. 099 whhos, golatin solution or iftheso aro 

### nOl available, drink largo quantities 01 wator. Avoid akohol. Call a physician immediatoly. IF INHALED: Romovo victim 10 fresh air. 

### If not brea1hing, glvo artilicial rasplration. Administar oxygen 

### if n&<:Ossary. Get modical attention. 

# PRECAUTIONARY STATEMENTS -PANGER WfjAZARDS TO HUMANS AND DOMESTIC ANIMALS CORROSIVE. Causes eye and skin damaga. May belatal

### ifabsorbed through skin. Harmlul ifswallowed or inhaled. Avoid brealhing _pray misl. Do not get in eyos, on skin or on cbthing. Keep away lromdomestic animals. / NOTE TO PHymclAN 

# V There 

### Is 

### 00 spocilic anlKiote. All tfeatment should 

### be based on observoo signs and symptoms 01 distress in Ihe pationt. Overe)(posure to materials oth&f than this product may have occurred. Victims of sevare overaxposure, by inhalallon, should be kepI under madical observation for up to 72 hours for dalayed onset of pulmonary odoma. In a victim 01 over-exposure by ingestion, carelul gastric lavage Is (4quirod duo to the possibiIJly 01 stomach or esophageal perforation. This material is an 

### acid, but use of alkaline substances 10 neutralize it Is contralndicatod. 

## PERSONAL PROTECTIVE EQUIPMENT (PPE)

. AppIicatofS and other handlers must wear coveralls over short-sleevad shirts and shorl pants. watorprool gloves,**<:ha~l.rosislanl** lootwear 

### plus socks, protective eyewoar, chamical-resislant hoadgaar lor overhead axposure end chemicat·roiJs1antapron whon cleaning euipment. •••• : •• :.: 

## • • • • Discard clothing and olhor absorbed malerials that have been drenched or heavily contaminaled 

### with this productsttltltenttale..Qp•• not rouse them. Follow manufacturer's ins:lructions lor cleaning/maintaining 

### PPE. II 

### no such instructions for washables,"use delorgent • and hot

### water. Koop and wash 

### PPE llOparal&1yfrom other laundry. •• •• 

## •••••• 

### •

## •••• Whon handlers use closed systems, oocJosod cabs. or aircralt In a manner lhat meots lha requiremonts listOO In the"Worker Prot$;li'bll•• Slandard (WPS) for aglicultural pesticides (40 CFR 170.240 (d) (4·6)J. the handktr PPE roqulremonts may 

### be roduteQ",";nodilied 

### a; specilied in

### 1he WPS. •••• • ••••• 

## User Safety Recommendations Usors should wash hands bolote eating, drinking, chewing gum, using tobao::o or using the toilet. Remove clothing immediately 

### if peslicide gets inside. Thanwash body thoroughlv and put on clean c{othing. 

### • 

## •• 

## • •• •• 

## •



## •••• • • 

## • ••

•• ••



# 43 ••••• 

# • • 

## •••

## EN)fIRDNMENTAL HAZARDS F.ofterrestri8!uso8:)do not appty dlrecliyto water, or 10 areas where surface wator Isjl(osont or 10 (ntonida! aroas belowtho mean high Wator

### marlC'UOiffit conlamlnato waterwhon disposing 01 equipmontwashwators, Do not contaminate walet used for irrigation ordomoslic purposes, 

## USE PRECAUTIONS Do not apply PREpl'M brand Ethephon through any type of irrigation system. Avoid spray drift 

### to nearby crops as this product wiD causo modifications In plant growth. Plant Injury or reduood yiokls

## wm result. 

### Do oot plant another

### cropwithin 30 days aftertroalmen!. Mix only the amount of spray you exPQCt 10 use each day. Do nol allow mixed solution to stand overnight 

# DIRECTIONS FOR USE It I •• violation of Federal law 

### to use thl. product In a manner Inconsl,tent with It. labeling. Road ontfro label bofore using thl. product. 00 not apply 

### this product 

### in a way that

### wHi contactworkers or othor persons, either directly orthrough drift, Only protected handlers in fhe area during application. For any requiroments spO(:'lflC to your Stale or Tribo. consult Ihe agency rospons'lb!e for

### """~"'. regulations.
product only in a.ccordanco with 

### ils labeling and with the Worker Protection Standard, 40 

### CFR part t70. This

### standard for tho protection of agricukural workers on farms, foresis, nurseries, and greenhouses, and handlers of It 

### conlains requlremenls for training, decontamination. notification. and 

### emorgency assistance. 

### 11 also and expectations pertaining to the statemenls on Ihls label 

### about personal protective equipment (PPE). i and 

### restricted-enlry inlervals. Tho 

### requlremenls in this box only apply to USGs of 

### this product that are covor&d by 

### the Profoclion Siandard, onterorslJowworker entry inlo treated areas during tho restricted-sntry inleNal (REI) of

### 48 hou/'$. roqulrod for early entry to Iroaled areas that is 

### permitted under the WOl'ker Proloction S1andard 

### and that involvs$ conlact that has boon treated such as 

### plants,**$O~** 

### or water is 

### coveralls over short-sleeved shirt and short panls, waterproof 9IOve.", 

### footwear plus socks, 

### protoctlve eyowoat' and chomlcal·resistant headgearfor overhead oxposuro.

not 

### contamlnale waler, food, or loed 

### by storage or disposal. conlainer is 

### broken or 

### contents have splll&d. lollow aU 

### precautions indicat&d above 

### and clean up immediately. 8&foro cleaning

on trousen;, long 

### sloovod shirt. protoctlve gloves, and 

### goggles or fac. shield. Soak 

### up spin 

### with absorbent media**~'~;~7.;~:~h** 

### orothersuitable- 

### material and dispose

# 01 waste at an approved waste disposal faclrtty. II 

### DISPOSAL**I~,"'icid.wasles** are acutely hazardous. fmproper disposaf of oxCGSS pesticide, spray mixlure, or rinsate is 

### a viofation of Federal wastos cannot 

### be disposed

# 01 by use according to labef instructions, contact your Stale Pesticide or Environmentaf

# Co,,.",'1**I~~~:;;~~'::h,~e**Hazardous Waste represenlative at Ihe nearest EPA Regional Office for guidance, 

# II DISPOSAL

### {~o~~~:~~~~:~::~~~ containers. Then offer lor recycling or reconditioning, or puncture and dispose of in a , .. 

# ,'a'l'l**I';~~~~;~'~~** 

### or· by state and local authorilies, by 

### burning. 

### If contalnor is 

### burned. slay oul ofsmoke. 

# I' REFILLABLE CONTAINERS



## • •• •



## •••• • • 

## GENERAL INFORMATION COTTON 

# ..

# ..... • •



## •• • •• Afoliar spray of PAEpnI brand Ethephon will accolerate opening of 

### mature unopened cotton bolls and enhance

### del"'~i&n whichoono: retull in earlier harvesl with an increased recovorable yiold. PREpt"U brand Elnephon trealment on cotton allows lnoreasad efflclanc/ lrom aonce-over halVest •••••: 

# 44

# --

-----

TOBACCO (FLUe·CURED): A 

### foliar spray of PREpn, brand Ethophon promotos oarly, unilorm '"yellowing· of maturo tobacco. 

### PAEpm reducO$ 

### curing tlmo, allowing more officlont use 01 curing barn spac." and incroased control ovor harvGS! schoduJes. 

### SPRAY PREPARATION Add 112to 3/4of tho required amount 01 walorto the spray tank. Start**ag~ation.** 

### Add Iho requirod amount of PREpm brand Elhophon, end tho romaining amount of wator. Proparo only as much spray solution as can be usod on tho day of mIxIng. 

### Do not aHow spray 

### solution to atandovornlght. 00 not spin 

### theconcentrated

### producton spray equipment, or any alrplane parts.**~Y**SPiLLS SHOULD BERINSED IMMEDIATELYWffiI PLENTY 

### OfWATER. 

### Use ofa nurse tank 18 highly rocommendod for avoiding possible splUs ofconcontrated lormulatlon on spray equipment or any airplano 

### parts. TANK MIXTURES WITH DEFOLIANTS AND INSECTICIDES PAEpm brand Ethophon 

### Is compatible with DEF', FOLEXs, Oropp2. Harvada3• Methyl Parathion, Gulhicn', and**Malalhion~.** PAEpru 

### may bG applied 

### in sequence Ot as a tank mlxtuta (00 NOT TANK MIX WITH DESICCANTS IF COTTON IS TO BE SPINDLE HARVESTED). Follow aU appllcablo UM precautions and rate poraero rocommendations on 

### labels of products 

### applied as tank mixtures Ot 

### In soquonce wkh PREP N brand E1hophon. In some casas Slight tedUCIion 

### in boll opening taspen

..has been observed whon lank mlxos wkh defoliants ware used. 

### Good agkaUon 

### in Iho spray tank Is ossonllal and a lank mixturo should not be allowed to stand wkhaut agitation fat more than 5 to to minutes. Road and absotVe all appropriato label use dlredions and precautions

## tottoo defoliants and insodicides used.**~OTE:** Undet CGftain oondkions, tank mixtures 

### 01 PAEpru brand Ethophon wilh doslccants contaIning sodium chlorate could
• «'I5Uft in the formalion 

### of hypochlorous acids which on heating 

### will emit laxic chlotide fumos. EQUIPMENT CLEANING ' eB&causa of the acidic nature 

### 01 this 

### product, prolonged exposute to spray deposit 

### will damage 

### acrylic plastics. certaIn paints, and (/ metals. Rinsethoroughfy wkh a dotergent and water all exposed acrylic plastic-type materials (o.g.• aircraft windshields), and painted surfaces within an hout after exposure to spray deposits. At tho end of oach day, rinse thoroughly with a detorgonl and water aU the molal parts of the aircralt and tho associated spray oquipmont exposod to tho spray doposks

. 

# • •

• • •••••• •



# .... • •

•••

### • • • • 

# ·

..... • 

# · .. • 

## •

•• ••



### • 

## •• •• •

•••• • • 

# .. 

# .. 

# ..

45 •••••• 

# . " 

### • 

## • •

### •••••

• •

•• 

### ••••• • • 

# ...

# ..

•••••• • •

•• •••••• 

### • 

## • •• ••'

# .. 

# dOTTON

EXPECTED PREPT).I ONE SPRAY VOLUME APPLICATlON USE CONDITIONS 

### RATE GALLON (GaIS/A) 

### TIMING

•LOS A.I. Acr

..**.~I["·** 

### PREPThi Hot and

### dry 8O"For 

### 1113 1.0 

# • Apply whon the number

## ?f SoU Openor" higher maturo unopened bolla ,Is 

### Dry and 

### 75 10

### aooF 2 1.5 

# • 15·50 2·5 sullicienl 10 produce**I~G** 

### desired crop. See below for Coolbot abovo

### S5°F 2213 2.0 3 lest 01 boll malurily. Treatment uniformly opens or 

### bolls 710 14days oarli8f. Rank ""on 

### PREpnt' + High soil moisture 

### 113 0.25 2. IS-50 

### 5-10 Apply 4 10 7 days.pr.Ie'.'O 

## FOLEX· or PREpllI boll I 

### Tank 

### High lortility Iovel

## a~bmlen.**TO_b&-;'~M** Ix or 

### a SO<'!uential 

### nol in 

### boll Rank coHon I 

### High soil moisture 

### 1/3 

### 0.25 2' 10-SO 3 ·10 

### Apply 4 10 7 days prior 10 

### Defoliant Tank High fortility level 

### PREp"N boll opening 

### Mix Rank cotton 

### application. To be 

### used as a soquonliallroatmenl with, not

# in**pl~,of** PREpnt boll Pr.·Condltfone( 

### Hot, dlY. aboVe**80~F** 

### 213 0.5 12 Apply 4 10 7 days prior 10 for 

### Defoliation Cool, abovossoF 

### 1113 1.0 

# • 15 ·50 

### 2·5 dofolianl. Enhances lop crop defolialion reducing or dolerioralion 01 bonom-

### c.~p Rank cotlon and allows lor earlier 

### *Pratreatment With Defoliants Pnor to PREpru Boll Opening Treatment IIlhecoHOn Is overly 

### rank or laying down in Ihe middies and good spray coverage 

### of Iho 

### bolls with PREpDI 

### Is diffICUlt. a pretrealmenl with defoliantswhl 

### be usofullo improve boll ooverage with PREpn.!. Use 

### dosage ralos 

### of PREP'"" brand Ethophon recommondOO for bon

### ~nlng. Road and observe aU appropriate label use directions 

### and precaulions for Iho dofoHanl used. ·*In California and Arizona use avolume of no loss Ihan 

### 5 galloos per aero loraorial applicalions. 

# ft:'OU Maturity A

### bon is mature when il is 100 hard 10

### bedenied when squeozed ootweoolhumb and lingers, 100 hard 10 

### be slic&<:l**w~h** a sharp knHe, and when Ihe

### $800 coal becomos lighl brown in color. 

### Use 

### Limitations Do not exce&d a maximum 012.0 lb. aVA lorcombinod usesof PREpm peracre peryear. BoU Opening: 

### Do nollank mix PREpm brand Elhophon with a desiccanl if Ihe cotton 

### is 10be spindle harvostOO.**Pre-COnd~ion** for Defollalion: Do nollank mix PREpni wilh desiccants unless plant desiccallon is required. 

### Do nol use a delolianl bolorolhere is sufficienl maluro unopened bolls 10 produce Ihe doslrGd yield (see Generallnformalion section on how 10 leS1 for 

### boll malurily. • • WHEN TO HARVEST COTTON : ••••• 

### 00 nol harvesl colton soonGflhan 7 days after aIroalmonl**w~h** PREPot brand Elhopoon. 

# . ... •

## •••• •••••• • •• • • Observe Ihelrea1Gd 

### crop and harvosl when optimum boU opening has boon reached. Too early harvosl mighl roduco Ihe.full adVafllt9Jl••• ollhetroalmonl and 100 lale II harv!)51 may resull in reduced quality and loss oIlInl which**w~1** drop lrom the plant. •• •••


# ...... ••••• • • • 

## • 

# .. 

# ..... • • • •

•••• •••••• • • • 

# .. • 

# .. • • • ••••••



# .... • • 

# .. .. • • • 

# .. .. 46 

# /

### Crop
Directed Spray Application 

### PREPni PInta/Acre
1113



### 1 113 - 2213

USE LIMITATIONS 

### 50-SO

4O-SO**~---------------------** 

# TOBACCO (Flue-Cured Only)

Use drop nozzlos. gpa at 

### 35-40 2 nozzlos th. SpecIfic Directions

Treat only whon loaves remaining on 1h. stalk at. 

### maturo. To ensure



### , 'oaves are maturo. test spray sevoral tobacco plants as i s&etlan -Proper TImo ofTreatment· u••tho IowlJr 

### in a normally maturo crop whon oxperience Indicates that mInimum I 

### in<:iucornont is 

### requited. Uso tho higher talo when tho crop is heavy and has a tendency 

### 10 

### be

## mot. rank 

## or when lemperatures ate lower than normal. 

### Always test spray to determine 

### if the tobacco is 

### mature onough to respond to Iroatmentwijh PREpThI brand Elhephon, Apply over-the-top PREP""' brand Ethophon spray as a fine mist using thr.e nozzles {ono nozzle lips avO/' tho center 

### of the plant. and on each 

### so all loavos at. covered sImilar to the 

### I

00 not 

### apply PREpni brand Ethophonto immaturoleavos as this can rosult in unsatislactory coloring, wolghllo$$ and reduced loat quality. 

### Do not 

### allow tho crop to ovor ripen in tho lkild after using PREpno brand Ethophon, sineo this may causo some reduction In yiold and quality. 

### Do noltroat**befor~** anticipated majorstormwhich could prevent harvGst and result in crop loss. 

### Do not apply PREpn.i 

### brand Ethophon If rain i$**ox~&d** withIn

### 4 hours. APPL1CATION TIMING SUCCGS$lul results with PREp1101 call lor troatmont when leaves are maturo, notovat!y rank groan whon sprayed. To easily determine the proper lIeatment timing 

### and tho numberof laaves porstalk ready lor harvest, tost spray sevoral plants In morethan one location in 

# 4E 0ach field aildOOseNo the response. Maturo leaves

### wU/ begin to yellow in 

### 24 to 

### 72 hours. Test leaves that fall toyellow 

### In 72 hours aro matute and are not ready for PREpn. brand Ethephon treatmont. Wait a fow days 

### to permit lurther natural maturing, then make anothertest spray or"maturity" check.. / ..,.vhon you have confirmed tho numbor of Ioavos por pb.ntthat 

### will color, you can determine tho numborofacres to treat in order 

### to 

### lift 

### Whebarn. Prepare your teS{ spray by mixing 000' teaspoon 01 PREpnl In t quartof water. Spray each test plan! with 

### about 1 oz. ofthis mixture, covering allloavDS with a fino mist. PREpn. brand EthophonwUl not color immature sprayed loaves. WHEN TO HARVEST 

### All maturo, sprayocf leaves

### will begin to colorwithin

### 24 to

# n hours after PAEPn. brand Ethophon application. The yellowing

### proco$S is weather dependont; cool weathor wid delay, while hot, sunny weather can speed upthe procoss. Harvosttraated tobacco when waves have reached the desired color intensity. 

### Do not allowtobacco 10 become over ripe before starting harvest leal drop can occtJr when tobacco is ovor ripe and Iolt on the Slalk. 

### If a number

### 01 the bottom leaves have yellowod at-the timo oftreatmont, they 

### should be harvestGd priorto spraying wfth PREpn. brand 

### E • •

thophon, : ••••• Wllh

### an over-the-top application, harvesting

### can commence 

### 24 hours altar PREpru brand Ethephon appHcation depePdiN on**~.:** conditions or to avoid over rips tobacco. Tobacco harvested 

### 24 hours attertreatmen1 will require moretime in the cotqrmt'hase

### of 1ho • curing process. .":•• : CURING PREp-t'M TREATED TOBACCO •• •• Curing procedures rue as much an art as a science and oach cure musl 

### bejudged on tho basis of tobacco**cond~iog:i1lf4rVal** betM$Tt·• treatmenl and harvesf, weathor 

### and type of curing facility belore proscription temperalure and vontllalion Ichft4ulos cottrbb· estabUshed. To obtain maxImum quality, 

### cam must 

### be laken 10 observe and control tho curing process closely,**e~ty** during the late**~coJormg"** and early**"drying~** stages oftho

### leal. ••: ••: PREP'N brand Ethophon treated tobacco 

### will have started tho coloring prootss when harvested, reducing the timlJ**~uir"** in the ". coloring phase ofcuring. Treated tobacco should be driedfaster. 

### If

### tobacco leaves aregroen orcontain some groorfwNta'harveIlW:·:**~** may

### be

## noceswy to color them fora low hours. Ifthe leaves are completely yollow, temperature and ventHation must bo.ad!ustM lit" 

### a mannorto dry the lobacco

### as last as possible**w~hout** scalding. Oncethe IGaf is dried (314 dry), you shouk!

### follow 

### rfq,rgtaJ procedures lor curing. Since PREpnt brand Ethephon lreated loavos cure laster. treated and untreatGd loaves should not

### becured togethor In tho samo bam. 

# 47

# LIMITED WARRANTY AND DISCLAIMER Tho manufacturerwarrants (a) that this 

### product conforms to tho chemical description on tho label; (b) thai this product is 

### roasonabty lit for tho purposoo sat forth 

### in tho dirOClions for use whon 

### it is used In accordance with such directions; and (c) 

### thai tho dirGCtions, warning and othor statements on this label are basad upon rasponslbte exports' ovaluatlon of reasonablo losts 01 oHoctivenoss, of toxicity to laboratory animais and to planls, and of residues on 

### food 

### crops and upon reports of floki oxperlonc:ct. Tosls have not bean 

### made on all varieties or In all states or under all conditions. THE MANUFACTURER NEITHER MAKES NOR INTENDS. NOR DOES IT 

### AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES. EXPRESS OR IMPLIED. AND IT EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANTIES OF MERCHANT-ABILITYOR FITNESS FORA PARTICULAR PURPOSE. 

### lHlS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND 

### AlllOSS OR DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENTWITH THE lABEl 

### DIRECTIONS. WARNINGSOR CAUTIONS. BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR 

### SELLER'S EXCLUSIVE lIABIUTY FOR ANY AND ALL CLAIMS, LOSSES, DAMAGES. 

### OR INJURIES RESULTING 

### fROM THE USE 

### OR HANDlING OF

## nus PRODUCT, 

### WHETHER OR NOT BASED IN 

### CONTRACT. NEGLIGENCE. STRICT LIABILITY IN TORTOROTHERWISE SHALL BE LIMITED. AT THE MANUFACTURER'SOPTION. TO REPLACEMENTOF. OR THE REPAYMENTOF THE PURCHASE PRICE

## FOR. THE OUANTITY OF PROOUCTWITH RESPECTTC WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHAlL MANUFACTURER OR SELlERBE LIABLE FOR SPECIAL. INDIRECT OR CONSEOUENTIAl DAMAGES RESULTlNG FRCM THE USE OR HANDLINGOFTHIS PROOUCT

.


### • onCE TO BUYER urchase ofthis product does 

### not confOf' any rights under patients govGMing 

### Ihls product or tho use thereof in countries outside of

### the

_ Uniled States.

IOEF and Guthion are r&glstered tradomarks of 

### Bayer AG, GGrmany. 2Dropp is a registered trademark of 

### NOR·AM Chemical Company. lHarvade is a registered trademark of Uniroyal Company. 4Malathion 

### is atrademark; of

### American Cyanamid Company• 

# • 

# •

RhOne·Poulonc

### Ag Company P.O. Box 120t4.2 

### T.W. Alexander OriV8 

### Research Triangle Park, North Carolina 2n09 

### PREP Is Ihe trademark of RMne·Poulenc. FOLEX is 

### a regislered trademarkof RhOno-Poulonc

. PREpN brand Ethophon for Cotton and Tobacco (PENDING) Submitted to/15f93. 

### • • 

# ...... • 

# ......

.... " 

# . . . 

# ....

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## , 

# ,

# ", '" (A) Unitud Stolos 

# ,**PIOlCc~o!)** AI1t'nly 

## r- Registration i(',:')' du·t,I;!Jr ,',\:,'l,tH 

### ! 

# &

# EPA Otlico 01 Pl)sticido PrcglO!1!5**\H75('~C)** 

# t=: Washing/OIi, DC 204(;0 

### Amendment 

## Applloation for PestiddB: Other 

# 1"70 'i'; '- ,J '-"'",

N!!!llbm

# !~G**P~rk~)i** " 3 ." 

## 264 ' . 

### ,

..**-~** --**I~** 

# [1 :4. CcmpanylPloouc! (Nome)**PM~** 

## 12 

# _J";,,,,:;**Ht':;.~n~t** 

# . PREP"" brand ethephoJ1 for 

## Cotton ilnd T,
5 Name nndAddlc5$ oi Appi,enn! (Inr;;lJd!71IP Ct'lfaj ! G. Ex!':: I!t 'd !1ClV\CN. 

### :n -,wi:., l,{nASt:;C:iC"**:':.i~;.;.-** 

### :--'

Rhone-Poulcnc Ag Company 

### ttbill).**n:~** p!c,dlJ(:: h} S"'1'\:H 01 id(!n!;co! ,n f:.dni <):;,!i:w, aMi L".JH .'J 

# ! 2 T. 

## II.. Alexander' 

## Drive I 10 ! 

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# He 27709 1 

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## Addition 

## of retllrnable 110 ga 

## 11 on 

### cOlltainQr l:occr';;)endation 

### to last 

## approved EYA 1abe1 

## Other contiliner sizes 

### of 

### 1, 5., 

### 10, Clnd 

## bulk st 

### i! 1 be 

### used.



# ,- Section II! M.",I,I Thl. I VillI



### , , 'i I 

### iUn;! 

# , I 

## "P,,",,) '''''''.01' " 

# 5]**::~.** 

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### , con!"irWf P;lck<l:jo w:.11**O~hc'** .c'_, 

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### l'latTen 

## Davis Senio!" 

### Registration )'l0..'lager 

### 919-S l

### i9-2379

CcrtiliC<lI!on 

## , C·,,,, ",:","", IUHt,ty ma! tho**r.![lh:ma:'\f11~** Ihave n1nu'J (II!**!h,~** ;';'(0, ilod nl!**J!1~1;:h:nDnl~** !1:c·f(·!j ,"10 ""'"**::1t';)1!;:)~_!** lnd r;("m(ll )1&**;:";"~,,,,-,!d** IndmowloOgc lho! any knoWingly tulw or mi';i<},llJrrg S!,;l\c,r;en! may 1'-0**Pt'i1'~!.J)'i2** ;;y "'.0**0~ 'r:T"~:-;;L~'lJnt:or** **ISI",..,p~t!)** ooth undol ;"Jpp!'(;"1hln Il'IN.



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## Davis 

# 49

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### eo,m 8570·1 i 

## V,·,,', ." 'i" i '0 , 'P! 

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# • •



# • • RHONE-POULENC AG COMPANY 

### ETH 93-28 

### October 15 ,1993


## U. S. Environmental Protection Agency Office ofPesticideProgram DocumentProcessing Desk Room 266 

## A, Crystal Mall No.2 

## 1921 Jefferson lJavis

## Highway Arlington, Virginia 22202 

## Attention:Ms. Cynthia Giles-Parker ProductManager (22) 

## FungicideHerbicide Branch Regislration Division (I-T7505C)

DearMs. Parker:


## RE: PREP® Brand Elhephon for Colton and Tl)bacco EPA Reg. No. 264-418 

## Appended arc threelabels for Prep that haveadded a section fOf 

## mini-bulk returnable containers. This is tile 

### onlychange from the last EPA approval the wording for therccydabl::> 

## containerhas been approved previously by 

## EPA for a numberofourproductsincluding bromoxynil. We trust this minordlange maybeapproved promptlyas productiGTI for 1994: saleswill begin 

### by theend oftheyear
. 

## Since no data arebeing submitled

## orcited to support this 

## label amendmentwe believe that an offer to paydata compensation 

## should notbelIecc::.sary. An 

## application for amended registration is 

## appended to complete 

## this submissiun.
We

## apprcciilte yourassistance. If

## you haveany qu(,stions pleasecontactme 

## pro'llptly.

Sincerely, 

# 'If// 'Warren A. Davis Senior Registration Manager

''0HOx r/),4 2 l'

....**,~~[,·M !l),~**  :COl;" fl(SfAFlCh'lKII;NOLl PAri".**n'~** ;<;:./, 19H1)**S~<j·ZOO::r** 'Un..i1'ATlDNM. 1Hf:<.**~j'jW'fH 'l,'-,'~jiB**  ;,'**I',:'LHW[~ ,\.\~**  "(I' mTfftNATIC""Al O:SflWUlor--. <,Hl','::r:: '(**Lc~. 1k~il<**  r; .l')JJ,I:' l.r';:',"'8ill-j·W**~"** 

# 50Pl<mfJ. fUdltutructhms 

# ."_f."",
(A) 

## . 

# X Registration ,OPP' 

# &EPA**t~/;IlCide:** _ Amendment 

# 197043 = Other

, " 

## 264-,//[( 

# tEPC. i', 

# 0,.,,,,, 

# o Restril;:/Od f4, CompanylPrriduct{Namo) 

### PM' 

## 22 

## PREP® brand ethephon for Cotton and 

# I' !Add!",. 6, Review, 

### In, "



## ,'"

# ~9**Com~any** t?!.(ii:-;"y produclls simUar 0; idenlical in

### composition and

### labeling 

## 2T.-Ii. DrlVe 

# "0: RTP, NC 27709 EPAAog, No, 

# D Checkifthis 1$anowaddrou



# - Explain boIow Rnal printedlabels- 

### inTOsponso 10 Agoncy !cUMdal!id In rofipor1W to Agency kltrordntod 

# r-- f- 

# r-- "Me 

### Too'**AppIiCa~OfI,**



## .. EXplain boIow<**~** 

# I 0!Iw-explain below, I Use addioorml pnge(s) ilnawunry, (For wclion I and S&ericn II.) 

## Addition of returnable 110 gallon container recommendation to last Other**con~ainer** 

## sizes of 1, 5, 10, and bulk still be used. approved EPA label,

III 

# 'Bo' 11", 

# , I""" 2**~'** 

# 51 v,,' ,-- Yos



### - Yes 

# r:x:- ;;rubc

X N. 

# - N.

# ~ N.



### , Ne, par

## ~:v.",'. No, P"f 

### • Certllkatlonmust

### be "-, 

### conroinu coommer 

### I 

# "Olabcl 110

## (;:\!,:~'(ne~) i '


# ,**~!'"~** 

# "'",,''''''' ".pn",,,, 

# r= o <JmM, ) 

## eon,"",

# ""~ Nrune 

### n

..

# ,~~'2;7'i'

# • 'J""'" 

## Warren Davis Senior Registration Manager 

# ..,. •• 

## ,6



# ..:

# .. 1certify Ihn! tho 51t1lements I have**m~**on this 101m nod all altaciunonltl thcr-eto flM 1fI.Ie. accumll) and

### oompicw. I ncknow!edge-Ihn! any knowingly fwoo or**mil>~adinli** atalefMfI!may be punblmblcby nne OfimpriMmmIm! or 

## • both undorappkabfolaw 

## • 

# ..::: I'

# j(/~ ;.) / 

# b I' Ti"" 

## • • 

# .. 1:J

# ."LIe**~~.** • • • 

## ••••

## (~:/: (' 

## •••• • 

# a:"""( ';C :CC: 

# ... • • • 

# .

# .

•••• 

# I' T,pOO N""" 

## 15 

# 0"" Warren A. DaviS / 

# !'i1 

# '"",1'''', wnjro , tVA ' 

# ,.-

# • 

# • PAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS

INSTRUCTIONS: 1h1& form \$. to

# '* uud ter 

### all applicatfCfl$ 

### tor nw 

### registration, end I,l$I: rer09istrlltioo,**~t.** restbllliHlon, to applieatlOllll for notificat!QI"I:I!; fiMl printed tahetiflQ, reregistration, etc, 1>"1 order to pranss an awllcutioo (or a 

### rwu Ngistratioo !il.tmitt«f on this font. the f611cwlno Nterhlt

.. t**IU;C~** the lIflPUcation: 

### 1. Certification with**R~t** 

### to tftstlon of 

### Pata (EPA Form a51O-29). 

### Ilf not exempted by 

### 40 erR**'52~81** 

### (b) (4)1; 2. Coofidentlo\ 5t31:0$00t of fotmJla (8"A Fom M1O'4): 3. fotmultltor's**£x~tiCl'!** StatCiMf!t (li'P" f-ONl'l asro·27); 4. five cop!" r..f draft 1$001 Ins; 5. lnrM coph!tI of any dolts sutnrtted;: 6. Authorization letter where 4pPllcaole; 7. Matrices**~en** $pplkable. Slb!I;u;oo Qf l&bellr:-g • labellf&f 4hould firlt be stbIIlned In Ute fom I)f draft**l~l!I** with all awlic«t{oruI for 

### rwu rasistratiQ(l. Suel! draft**t~t$** !64Y l:w In the foOll of 

### t'r'f*J l4bd teat on 8.5 j( 11 Inch poptr ;'U' 4 mcckllp 'of the proposed l&bel. If ptcparoo Ill> fI**~k~,** It**~houtd** Iw cQO$troetecl io m.>dl e !illy at to feeHIt,a@**~tor.** !n iIfI a,s x 11 ioch fi

### tJ:. Hoekup labels &igr;iflcantly Yna(ter thM 8.S )I; it 

### theM. dloo!d ba lIJO'.J1ttd Of) 2.$ x 11 Inch paper for**$}.tt:missl~.** St;tajnioo of Data**~** Oata ,u\::ImlttOO !I'! li\JPpOft of thh- apptielttloo!!l.$t be $dimlttti4 10 M;ccrdam::tt with Pit Wotict &-). 

## SPECIFIC**INSTR!J!alQH~:** r[c;>!;(t n;ad th1i! iNtrud:f\W1S tI!itoo below befon !;0q>leUns this <>pplicij,tIOfl. firtt ooteN!1lr.e the tY!X' of revlltfMi'w**~l;Ctlon,** liM&O in ,Heck A, for wlidl yIJlJ life stbnltting thit applkllt!co. for applications t!bll!rted In**c~ctfoo** with Ml1w Ker!htrtltlon &ctiCO$, £«:t\oro I, !II, M'ld IV 1W$t**~** cWptetoo by the awl 

### iccnt. For aWlkittlcm**~j** tted !n c0VWttlon with**~** r&gigtretioo actiot'4;, rHub!iiss!ons, notificaticro. rerltgletratiorm, etc" Section:; 1:, fl, wd II! l!ll.mt be CM1plllted by the epptiCMlt. Sled, A " Ched: the apprcprlate c-ctlon for lilich yOO'!lfh $l.lbIlttlng thlf; form. 

## SECTION I**~** thj¢ nrt{OtjOO nJtt i»**,~IQted.** I)';' nppl f.:abte, fCf' lilt reg;t:tratIM ACtiooS. 1.**~JPr't'dJct ~**  - !nnert 'roo,.**~~.** If «llII ho bEen**tlnl~** by EPA. 11lh**~r** may hav'.! l»M- lIuigrwd to yet.! as liI I.XH:)e f'c!i/ittr1l'nt." 11 di:Hdbutor. O?" n W'I**IUtubll~h$IOOt.** If yotit" pl"oaxt: 1$ resiu<\'red, \rzert the**~t** 

# -. Z. EM Pl"CIduet M&nager

- If krmm, fill tn tht; I'l&M end PH nuwbe:r of the EPA Product HllMg.:f'. 3.**p~** cl_Hicotion

- Specify the**prope~ed** c!u$iHctltioo of this pr....oocL 4. ProriJct!tame

- fMer the CG'lp\ete prodltt fWl\& of**tM~** pesticide M it uHt llf'PtlK co the**I~I.** 1M flil'!\q I!mt bE sptt:itlc to this**Pf'~t** coli'. Ot$lltlltioo cf naw,r,; Is 11<:It: p!:rmltted**~** prOOJch Iif th/! 1Ii&f¢**c~ny.** !kI not**ir.::t~** 

### ant 

## brn**~ or,~**  l!f'>It dHiSIWtl/UW. 5

.... and**~** Gf AflpllcMt**~** The nwme of the firm or person 1II'1d**~e$11** sh6Wfl In YfJ<Jf" npplicilltlon 1$ 

### tta ptnon or firm to whan the regiurllrion will be if;Su«i. If yoo nfC lK:tirq In bEMlf "f mother party, you wmt twit authorintion frO$! that party to act for them in registrAtion M4tters. Art $ppllc&nt not rt$idlng in the united StAtes must have W'I 

# ,

&!.ltherlud "!IMt residing iN the Unit«:l Statoo to act fOf thell fn 

# an registration matters. Thft f'IMII!'**~ c~letoj**  ffllIltinsl ..,-kInas of weh an sgent nost**l>CC~f** this ¥plicotion. 6. E>:pedlted IIICVINil

- FlFAA slXtloo 3 (t) "3 (iI) prcvldH far e..:pedlted rw!cw of appifc;)tfcns fer reg\stratico, or**~ts** to OKlsting registrations, that are 3fmllar or**!~ticol** to other pesticide**pr~ts** that ore currently registtred with the EPA. In enkr for yoor appticlltiCf"t to be eligible for ftXP'lIdited revieli, you I#.W;t provicfu w with th-: EPA IhtgistratlM Hulber G#'Id prcd.lct

_ of the prGOvct )'i'A.I btlt!e\i"(! is similar to or idmtil:nl to your prodoct. The pro:iK:t _t be slmllor or identical 10 both fOllllUlatfon bOd 1aJ:::.eleci OO!!$. 

## SECTION 

# n - this $'ection .nJ&t be carpletoo for 1'111 tlW'iicatlO<"¢**~!tted** to amend the rtilistnltloo only of II currently reglstltNld pn:d.tet**(~t),** for tI (ftC\.blliS$\Ofl 10 rUponGe to on Agency letter, for fW)tificariQI'W to tM AswcY. (or lhe w.brn!s&fon of flool print«l IW"lHf1jJ, fer f>lfftglstntioo m'd for fI!'IY oth>lr actioo that p!!rtairm to iii !!IN£ifl", m-rgs!mt>l!rsQ**~.** This section is!l!U 12 

### !.m wed for II M>l I'It'fAkathm flU'**r~htt.tlon.** , 1. SUbject of**~iscion** - Check the "Wlkabl>l block Md provide tlH!**~** tetter date If awtopr]/lte. Provide a brief 

### explG04tlOf'j of**th~** purpQ§e(s) for the**~I$sjcn, s~h**  4'**~th.** addition of'f**$it~,** p¢@t or crop**(&p¢Cify)~; ~~**  thft cooHdentfpJ St¥Mmlt of fonwlfl by•••";**Iirer~hUati«l** lnblduiM"l g4mral label {lrvf$ic,--; of use dlreeti«w." Attaeh I separii"ti"'iMI':ff additional $p3CC Ill'**~**• 

### •••

## ••• 

## ZEtTlON**l~l1Q.~lling** 

## iiind Cgntainer InfofrnatjJIDl· ,hi4 $-o/::t,o-< !aJtt b cc",,"otet('!j ttJ all "Wi!crJti«lt**i~n«:l** in 1: ttfoo with new re!li$trilitlm'l "I" &ppllctblt!**_-.-:.4!.tnt~.** L.Jlp¢ of**P~if19** - Cum!; tht Gprf'ordatt:! bl0Cli: if 1<'13**f}f~£t.;d** dU 1:.'1' f.$(kfod in**~h; 'M;,~ht0d**  ,.$(,,«)Irl$ typ;'15. 1r.dkiH* 

### ttt. !ifn of the fnrlhddml r.d:et-,;; &'d 11tWb¢f' t<1F rtU;1\ Ltnuiner.**'~'Ud'** of**lW\~h:** OmtaImr • lrdie.llte**,~** of contajrwr h uhir" VI?:fust Mltt b& N!ro;eluJ. :L·"MdtiM**c-f.~t ~Mte**  - 5p$::ffy tht 0$t c0;'1hmtl\ 0f**~!l** nUnl c<:mtuirwn it;!' YOU1 (>f0'.:iicL

,_ &:f:m(s)**.n-lg~Ji** etmufner

-**s~dfy** t/"j'f tWt**CO\'\HY1f~** d 

### "q rUil1\**i:01t!~lrnft-** for ytAff tyf4xL**~,."iWfon** <If 

### tJ:¢**Dffecti~** - lnd!cstt-**ttli!~** to-:;;tbr. Y (he ';He Oir«;diYW- for '!Wi' prtXhKL .;,.•**~** in**~rd!** l1:lbt1 11'; IJfiixM t<t p¢¢dOct H..a\("\B t1)" 0<,1:00 prodv:t**!~\** IS attM:hA to ,,,,tojl tVlt'fit"lr. 

## •• 

# • S"tjpN**19.£~btact** 

# Point)

- ;hl; SlKtkn ilLsr u (:"'pkrd t0r #It g,0ptk<lti<X$ f01" Pt'Ji$tratltm m:tiOO6, Le., Mll pr-'Oducts .egi'(l.ratlw, fl"!l-tA.m!$idOCl, "_-t&:J,"**r;):r~"!1qrlilt;or),** t'tt. 

### l·S.**sclf-cxpt~~'Y.**

6. EPA Us

.. tx'tly. 

# 52

# • (,I' RHONE-POULENC

"-./



# I

I AHONE·POUlENC AG COMPANY ETH93-2B 

## October 15 ,1993
U. S. Environmental Protection Agency OfficeofPesticideProgram DocumentProcessing Desk Room 266 A, CrystalMallNo.2 1921 Jefferson Davis Highway Arlington,Virginia 22202 Attention: Ms.CynthiaGiles-Parker ProductManager (22) FungicideHerbicideBranch Registration Division (H750SC)

Dear Ms. Parker: 

## RE: PREP® Brand Ethephon ForCotton andTobacco EPA Reg. No. 264-418 Appendedarethree labels for Prep thathave addeda sectionfor mini-bulkreturnable containers. Thisis theonlychangefrom thelastEPA approvaltheworcling for therecyclable containerhasbeenapproved previouslybyEPA for a numberofourproductsincluding bromoxynll. We trustthis minorchangemaybeapprovedpromptlyas productionfor 1994 saleswill

## beginby the endof theyear. Sincenodata are being 

## submittedor cited 

## to support this label amendmentwebelieve that an offerto paydata compensation shouldnotbe necessary. An

## applicationfor amended registration is appended to completethis 

## submission.
Weappreciateyour assistance. 

## Ifyou 

### have any questions pleasecontactmepromptly.



## • • •••••• 

### • 

## Warren A. Davis •••••• 

## Senior Registration Manager

PO HOX It"Jl,\ 2'WAU::;(I,r·.[;Cfl CiH

### \'r F!E%A!1CH 1PIM,GU' P,\[j>( 'iC ?;:VJ (Of!.!)**S49-2[X>~** iNTERNAi:ONM ;UEXNt'f.j8U'l ;'N:JI';.'·f.j,\CY**,~rc** \·1[-**'MERHAflO~,,\I_** O,SlR nUl!Ot, 'F! ,_ < 'r' r'.lB[R**N~>;(!?T-** ;1'-i,;',','CI1SA>, N'<" I', co 

### •••• 

## • • 

## • • •



## •••• 

## • • •••••• 

### • •



# .. • • •••••• 

# .

# .... • • • ••••• 

## • 

# .. • • • •

•••

## • •••••• 

### • • • 

# .. • 

# .. • • • ••••••

0 ••• 

## • • 

# .. .. • •**[xce/.lei'l~1i**

## ''lferfD-'_'T;3:1CF P'.de ,r. ,.;d'-0\ er':e,1! 

# 53

# :



# • • •

WITH PA'tA
FEU SIG (DATA)
FEU PI!



### HUH plln


# FEU SIG (DIITA)
PI! 

# •

f ( 

### 'AlIT 'l'lIACI{ • 

## APPLICATION 'OR**~** 

## Init. 

## Date 

# NO pAn Init. Date FEU 

# :1/J!, Lii,)!y3

## '~I! '/ ' 

### I'M 

## 'c-'**~","** 

## '/ )

REGULAR 

## APPLICATION POR AMENDKENT

In1t. Date 

# NO DATA
FEU
PI! 

## Init. Datto

• Front End Proceasinq d.te

....in.d thi. application' 

## quallt!.. 

# tor tast track review ba••

## d on reqiatrant. 

## cIa!. of
-••-too". No .cr.an tor 

## aUbatantial a1a11arity i. made by 

## the Front End.

, !



# 54

# ,

: 

# • •

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460



## MARGARET CHERNY RHONE-POULENC AG COMPANY P.O. BOX 12014 10/21/93

RESEARCH TRIANGLE PARK NC 27709 OffICE Of PREIIENTION, PESTICIDES "NO TOXIC SUBSTANCES



## PRODUCT NAME: PREP BRAND ETHEPHON FOR COTTON AND TOBACCO COMPANY NAME: RHONE-POULENC AG COMPANY OPP IDENTIFICATION NUMBER: 197043 EPA REGISTRATION NUMBER: 264-418 EPA RECEIPT DATE: 10/19/93 SUBJECT: RECEIPT OF AMENDMENT DEAR REGISTRANT: 

## The Office of Pesticide Programs has received your application for an amendment and it 

## has passed an administrative screen for completeness. 

## During the initial screen 

## we determined that the application qualifies for fast track review. The package will now be forwarded 

## to the Product Manager for review to determine its acceptability. If you 

## have any questions} please contact C. Giles-Parker} Product Manager 22} at (703)-305-5540.



## sincerely I



## Front End -processing Staff 

## Information Services Branch Program Management and Support Division

RflcycledtRflcyclablo PIIr>\lIdlUIllISoy'Ctl!«.IIIi<M**~I>tt** tll.1**COIII~r>l** -' 1_so;:.l'e'o;:ycIM II\!« 

# 55

# ,**-~----~---**

PicaseroadInSfructknut 

## (A) ..,.

# ERDA
UO;IM 

# -0 M II, CompanylPfOOutl Number 

## 264-418 form.


## "DC ""in f

## Registration Amendment Other 

# 188582 for Pesticide: 

# t

# ~Ori"I"~~~~iI

# ;=1 fc-; "' m 

## r,:-::eo-m-".-",-="""":-:""-c q,,",-,,,.-:-)

## -----------fIP"'M~2.;--2~**.~-------- -~I** 

# 0 None 

# 0 RoSIrK:lOO 

## PREP brand cotton boll opener 

# IS. Name andAddres5 01ApplicMl (frwhJdoZlPCodv) 

## Rhone-Poulenc Ag 

## Company 

# P,O. Box 12014 

# 2 T. W. Alexander Drive RTP,.JIC, 27709 

## U Chockil/his 

### it

### a newaridffJ!i$ 

## ill 1

### 6, 

### 10 (b)(i). 

### my product 

### to: EPA Reg. No.
_____________**~**

Rnill printed labels in msponse 10 Agoncy klltordated'
_____________ _ 'M!tToo'Awlie3tion. QIhCf' o)'plnli1 below,
Ipago(,)il n&COuary. {For$octiooland$(H:-tion II.) 

## Notification: 

## (PR Notice 93-3) labeling statement prohibiting application to water.



# I'0 """"

IN,,,,.Warren Davis 

## Senior Registration NOTIPICATIOII


# .......

# _-

P£R PA

# HOTJCa" M-no .-y/ I

## 7~7' 

# i <. '7 7



## • • 

# ",,,



# .. ' 

# :)
•



## . 

# -" I

## ,;. 

# I' Iamity that tho statements j havo mJlld(} crtmis Iorm ar.d all I:lltllcilmeot3 thereto am1;\.1(1. IlCOJrale andcomplete. Inckrn:Y-NiadgalhatMY knowmgly Intw01 milleading slstemeotmay bepun!!h4\b/o by line orimprilonmMlIor both Ul'!dct

...ppllcabla law, 

# I' I' "', 

# /"'"U/1'1 /J/l,. Seniot Registration**Mana9~Y'** 

# I' T""", Nam. 

# 15 Daro 

### Warren 

## Oavis April 23. 1993 r:-I'**,~'o'** 

# ...,,"'"' Wh'" EPA Coo eopY 

### y,now·

-**~** ---- 

## :

# .... • 

# ":::

"::. ,,"

# .

....

# PAPERWORK REDUCTION ACT NOTICE and 

# INSTRUCTIONS PAPERWORK REDUCTION ACT NOTICE: PUblic reporting burden,for-this collection of 

## fnfortration'b,'estimateci to**aV(!r~** 0.8') hour per respon$t1", in.clu:Hng tfllC for rwf-owlng lMtructiO(I$} 

### simrehino ext$tlng data sour(_, gathering aM mtl!intalnfno the tklto needed, M'\d cOI'Iptetlno art:i,re.rietling the cotltction of**inf~tlon.** "Send cOOJIIO(jts regarding the hurdIN'! estimate or any other aspect of this eoUtx:tlOO6f information. lnchiding Wiif:$tiOM fo.r**n~duclng** thh; 

### burden, to Chief, InfonMtion Policy Sranch, p)o!·223. U.s. F.nvlror.ntat Protection AOWCY.**~01** "'StrMt,'SW, llashfngton. DC**204~;** ao;I to' the Office of [nforMtion ;l!'Id Rt'gVlatory**~ffllirs,** Orflce 

### M MMlOgMJl':flt and Budge:t. UOllihf09too. DC 20503, 

### INSTRUCTIONS: This form is to bt used for ali 

### I'ipPtJcatlons for**~** 

### rq[stratlon. end 

### we reregistration. Uler'ldnmt. resubfllsslcn, to 0pplicl,Iticos for notiflclltionil, flNt printed libeling, ror*9[&trotiOO, etc. tn order to procoss an ewUclitlon for a MW regil;tr(ltioo subriitted 

### on this form, tla fo[tOWlrlO .terfal JW!ft**l)C~** the 

### application: ," 1. Certification with Respect to Ciution of Dllta (EPA**roNl8Sro~29).** tlf I'lOt IIJl:tflJ,'Jted by 1j0 erR 152.8' (b) (4)); 2. confidentIal**StIIt~t** of fOrl!JJla (EPA rom 8570-4); 3. fcnwlator's EXaTptfoo Statl!tllWt (EPA rONl! 8S1tI·27>f 4. five copics of draft [abeling; 5. Three copies of any data**~uI:Jn!itted;** 6. Authorization tetter wherfl epplleable; 7. Motricell. where app[ [cOO[e. Stmlsslon of labetlng**~** Labeling shou[d first be st.br1ftt«t In the fONl! of th'lIft iabel& with3Ht IIpplicQtfoo& for n«I registration. Sut:h draft labels IN!>.,! 00 

### in the form 

### of t)'f»d lebiI[ tIIxt 00 8.5 

### x 11 in<:h 

### paper or 

### a**_k~** of the prOfX$ed tabeL [f prepared &s a !!lOCkup, it shwld be COMtruettd In such a WIY tUI to fDeliltatll' storal}{! -in an 8.5 x 11 ineh file. HO-::KUp labels signlficant[y $MIter than 8.5 JI: 11 inches should be fIIOIXItM 

### en 8.S 

### x it inch p4PIIr for stbrlinioo. Sub.ission of Data**~** 

### Data submitted in support of thIs app[lcatlon**~t** be**s~itted** in accordan(fI with 

### PR Motlce 

### 36'5. 

## SPECIfIC INSTRUCTIONS: Pleue reJXI the Im!roetforu; listed bEtow

## ~fore c.:;:q')lding this applictltien. first •. determine the tyPe 

### ot registrntion**~tjon,** listed In 

### 'lock A, 

### for which you**~re** submitting this application. for l!ppttcatlons !u/:mittcd in com«:tlon with )Ie., Rlt9istratioo actions, Sffcti«l$ [, [ll. Mid [V I'mt M cilltfjleted by the tlppliclIDt. for app[ !cations 5ttmitted in cO!'1l'i¢Ctton with**~ r~lstrat[on**  aet[OM, resubmhsiOl"tS

.. notlficatlot!$. rernglstratioos, (!otc., Stctions [, [I, and [V /lOst Iw 'Of!l)leted by tile applicllflt. stod: II**~** Check thE nwrcpritlte <'fet[on for uhicll yeo Grc: stbllittfng this form. 

## SECTION 1- lhil; iI(!et[en**m.J~t** be Calpteted, " app[icable. for 

## all registration &<:tiOM. 

### 1. CoItIpanyJP«dJct /ill.btu--**~** [nsert your**~** 1fUIb:Ir, if one ha, be«! NS[jr,ed by EPA. l'hfs**~r** lI'iIIy**h.~** bun tllIslgned to you as €I**ba~b~f** clistdbl./tcr, or $ an**e$tabll~t.** [f your product is reg\$:terw, insert the**Pr~t** 

### 2.

# ~~t**~JI~Titi** in tile MIM I!Od FfoI

# ~r of the EPA Product HaMGf!r. 3.

### p~**tt~~/M ~** **Y~'1ly** the

### ~opoted cbulfictltion of th[§

### ~t. 4. ProWct**~** -**~r:tru:'.;!l!.LS~lq~·,«pduct** MMpf thi!! pKtfcfde a§ It ,ullt awear on the label. l'ne I'\iIIM rust be $p¢C[flc to this prodlJct"oofy. Dup[ [catfon of NlIM§ is net P\lOlIltted GIIIOfl9 prcd.kte- of the ,tIM cOOf'Mly. Do not iocllde 1!>O"f brand 0/lI00 or**c~!\XIny** line dfligr.atlt.ns. 5, Waoi:t end**~** of Apptlcoot • The I'Wlfm! of the f1m er perllon and :.ddre!!>**~** in ywr iIf'P[ication I§**th~** penl«i Qr f[11Il tl) 

## mW! the rt'g1stratioo wi 11 !» i$4ooo. If,'100 are M:til'l9 in behalf l>f IMOther party, you I!fJ&t eubflit authorization irMl that party to.ret for them in rllg!f:tration rMltterl!. An awlicent not residing in tho:! united Stlltes _t hl\Ve un authorhed 1I9lmt fj!-$idif>lj [0 the Unit«l' States to act for them in 1I11 rC5htrtlti'on motterl!. The NiI!\I:iI' al'ld c.:;:q')[ete ma[[ing address of such an agent I!I!J5t accOO'pal'iY this IIflPt [catioo. 6. EXpedit!!d Revlw

. F\fAA $Htfon 3 (cl 

### 3- (8) pnw!d-ts for expedited fevllW of llpplic3tiQtl$ for registration. or**~t.** to existing**re~istraticnll,** that are slm[lar or identical to other pestIcide pr¢dvcts that are**c~rrcntty r09i~tered**  wlth_ the EPA. In order for ywr tipptication to 00 eifllibh:'for Il){p«lited revlw

.. you rust provide \1$ with the EPA Registration**JrI~r** end product Il/WIe of the product you ootieve ilS similar to or identicaL to your rwoduct. The produet m..mt be 

### simitar or idwntical !n both formulation and**t~ted** 

### uscs. 

### SECIION II·!Ofhfs s«:tion _t 00

### ~[Il'ted for all applications lIl-linltted to IlfflI!f'ld the re!Jistratfon onLy of III currently**'~f;t...-ed** Pf'lX:I&t**(A~tJ,** for a rU-lltFdssfon [n**rli~(!** to M1 AQ«IGy letter, for not[ficaticns to the Agency. for tim :l..IIlnts(lon 04'lMl.prlnted tab40[ lng, f(}f reregistr!Jt1co and for any other action that pertains to I) "§P!Kilfh:.- ru·rMiOJer!XI 

### .IK!iI.Wtl,**TII~** 

### slU'tion is!'&1!2.

### £t una fer 

### a flfl.r'I!f9[iCl'ltion fer ;"g:fs'tr.tion.**4~-si.bject:** "f ..miSSion**~** Clled-: th01r IIfPlicwle b[cek and providt the AgMty tetter eate if f>WtOflriate, Provide a bl-ief

"exp[4rnltiClloof"tJle pJrpe!.a(s} 

### tor the'$l!brniui'on, such.u nthe adtIition of ft site, pest or crop (specify}": '".mend the**.·~HdimttlJ(.·l1lJtroomt** of forw[:. by

.....; "reregistration !Qiplorv*('pneral lat rll'Vlsioo of \.I$e dlreetfOO$." Attru:h '''.CliXlrnte JX!iC''if additlM3[ Splice is Meded. 

# .... .


# . 

# '.
t5IION In·fracKaging and Cpotainer Information)

- This SactionllUu bo**c~leted** for all**flw[icati~**

\-Vfltted in cJttne<:tlon with ow reulstratlco 

### or .wlicllble**~ts**• • 111 lW 

### -of**P~llIG ~**  Cfwd:; the awroprhte block If Y-OIJI'" pr-cd.Ict }flU be pod:&ged in tht indicated I*-kugj ll9 types• • ·w,cate !1iq,'Ue of the ind[vid<.utt ped:etsc lind' t"!Ufixtr per retail cOl'ltainer.**~·T~** of .,tail.CMteiMf"**~** Indicate type i)f contillner in \KlIch proOOct wlll be mrht«l. 3. Loudon**~ofk:t.ccntmt$ ~**  Sp«ify the net contents of aU retall'c:ontalmrs for y«rr product. 

### 4. sbe{s) -ot·k\Ln COOt4joor

-**S~[fy** th11- net ContMts of 

### alt retail -containers for 

### your proOOct. 5. Location of JJe.e Dfreetions**~** Indicate the [oetitirm of thll' use direeti<rn: for your proc.k.x:t. 6,**~** in which tabel illl**IIffi~ed** to pn!d.to.:t

- Indlcatl? the method Pf"¢dJet lMI ill attK-hed to retail conttllr.er. 

## SECTION IV (Contact Point) • Thh Section I'rOSt be c<*pletlld fov a[1 appticatiCOf; for lteg[lItration actions, 

## i.e., I')¢Il prod.icts regfstration, r(fll!Jtmfssioo, "1I>t·too," rere-gi!:tratfon, I?tc. 1·5. Sel**f~exph;natory.**

6. EPA lJt:;e onty. 

# 57

# l LABEL INFORMATION PAGE 

# PREP'"M brand Ethephon for Cotton and Tobacco 

# MASTER LABEL
Routing: Product Development Product Manager State Registrations .egistration Manager 

# General label revisions:
• Revised the cotton tank mixture 

## u/d and added to General Information section the paragraph (Tank

mixtures with Defoliants and Insecticides)

. 

# • Notification 6/9/93

- 

# revised wetlands statement.


# Rate changes for the following: CA restrictions: 4l»rinting Restrictions:

• •••

• •••• 

### • • •



## •• • • 

## • • •••••• •

# ....

# . • 

# ·

•••• 

### • • •• • • •

•••• 

### • • • • •



## •• •• 

# 58 ...... • • • • • •••••• 

### • 

## •

•• •••••



### • • ••••• 

### • • 

### ••••• 

### • •

•

## • •••••• 

## • • 

## •• •

## •

### NOTIPICATIOII

... 

# ......._""VIIlW J

- ..._ .... 

## 3 11.11'11. 

# 7fI

# 2-/If 

# ETHEPHON FOR COTTON AND TOBACCO
For Commercial Use Or AgrIcultural Use Only. Not For Resldant/al Use ACTIVE INGREDIENT: Elhephon (2·Chloroelhyl) phosphonic acid·

........................................................

### 55.4% INEfn**I~IGRIEDIIE.NTS:** 

### ...............................•...•....................•.............•....................................................44.6% 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO
PRECAUCION 

### At USUARJO: SI usled no !eo ingles, no uso oslO producto hasts quo la informacion on la ollquota !8 have side oxplicado II



# STATEMENT OF PRACTICAL TREATMENT IF IN EYES: Hold eyolids open and flush**w~h** a gentle stroam ofwatorfor all03s1 15 minutos. Get medical attontion. preferably an ophthalmologist 

### IF ON SKIN: Immodiatoly wash skin with plenty of 

### soap and wator. Romovo contaminatod clOlhing and shoos. Wash clothing separaloly beforo rOUS8. IF SWALLOWED: Do not induce vomiting. Promptly drinka largo quantity of milk, egg**wh~os,** golatln solution or

# athose are not 

### availablo, drink large quantities ofwater. Avoid alcohol. Call aphysician immediately. IF 

### INHALED: Remove victim to Iresh air. If 

### not breathing, give artificial respiration. Administer oxygen if 

### nocossary. Got medical attention. 

# PRECAUTIONARY STATEMENTS DANGER .a/iAZARDS TO HUMANS AND DOMESTIC ANIMALS**~ROSIVE.** 

### CauSOS eye and skin damago. May be fatal if absorbed through sR.'tn. Harmful/I 

### swallowed or lnhalOO. Avoid broathing spray mist. Do 

### not got in eyos. on skin oron clothing. Wearluu longth trousers, long sleeved shirt. protectivegloves, and goggles or face shield when handling. Chango 

### to clean work clothes dally. Wash thoroughly with soap and watorafter handling and boforo eating, orsmoking, Remove and wash contaminated clothing bolore reO$e. Koop awayfrom domostic animals. NOTE TO PHystCIAN There is no spaciHc antidote. All treatment should be

### based on observed signs and symptoms at distress In the patient OVerexposure 10 materials otherthan this product 

### may have occurred. Victims 

### 01 severe oYGrexposuro, by 

### inhalation, should be 

### kept under medical observalion lor up to 

### 72 hours for delayed onset

### 01 pulmonary &demn. In avictim 

### 01 ovor-oxpcsufO by 

### ingestion, carelul gastriclavage is required due to the pcssibitlfy of.stomach or esophageal p&rioration. This malorial is 

### an acid, but uso of alkalino substancos to neutralize It Is contralndicatod. .:. 

# . ..... •••• • •• 

## ENVIRONMENTAL HAZARDS •••• : • • <\ ••••• 

### Forterrestrial uses, do not apply directly to water, to areas where surface wator Is present orto Intonlda! areas below

### tho moan hl9/t • wator

### mark Do not contaminate waterwhen disposing 

### 01 equipmentwashwaters. •••• 

### •••••• ••••• Do not contaminate water used for irrigation ordomestic purposes. 

## USE PRECAUTIONS Do not apply PREpllI brand Ethephon through any type of 

### irrigation system. 

### • 

## • • 

## •••• • •

•••• 

## • • 

## •• 

## ••••• • •••••• • 

## •

•• Avoid spray drift to n&amy crops as this product 

### will Cause modifications In plant growth. Do not plant anothorcrop wahin 30 days aftortreatment. Plant injury or reduced**yimpS~ft'** 

### result'·:··:

Mix only tho amount 

### 01 spray you expect to use each day. Do not allow mixed solution to stand overnight. 

### • • • ••



# .. .'


# 59 ••••

# DIRECTIONS FOR USE It Is a violation of Fodoral Law to UBO this product In a manner Ineonslstent with fts labeling. Road entire lab.1 before using this product. 

## REENTRY STATEMENT Mixers, lOaders and applicators must weara fult faco shield, 

### long trouSGrs, long 5100vOO shirt. gloves and boots to avoid as much skin 

### and eya contact as possible. Do not Ontor troated 

### flolds within 24 hours after application unless protective clothing is worn.



### contamlnat& wator, food, 

### orfead by 

### storago ordisposal. orcontonts have spilled, follow all precautions indlcatod 

### abov& and clean up immediatoly. Beforo cleaning up, trousers, long sleeved shirt. protectfvo glovos. and gogglos or faco shield. Soak up spftfwith absorbent modia such orothersuitable material and dispose of waste at an approved waste disposal facility.
hazardous. Improper disposalofOXCO$$ pestlcido, spray mixture, or rinsato 

### Is a violation 

### of Federal law. 

### of

### by use according 

### to label instructions, contact your State Pesticide or Environmental Control roplesontative attho nearest EPA Regional 

### Offico forguidance.



## GENERAL INFORMATION COTTON 

### I

. and 

### of in a sanitary

A foliarspray of PREP'll( brand Ethephon will acoolorate opening of mature un0p6nGd cotton bolls and enhance defoliation which 

### can result In earlier harvest 

### with an increased recoverable yield. PREpm 

### brand Ethephon treatment on cotton allows incroased efficioncy lrom

### a once-over harvest. TOBACCO**(FLUE~CUREO):** A foliar spray ot PREpno brand Ethephon promotes early, uniform**"yellowlng~** of mature tobacco. PREpDI reduces curing time, allowing more officiont use ofcuring barn space, and increased control over hal/vost schedules, 

### SPRAY PREPARATION Add 112

### to 314 01 the required amount of wator to tho spray tank. Start agitation. 

### Add the raquirGd smounl of PREpt'IoI brand Elhephon, and the remaining amount 01 water, Prepare only 

### as much spray solution as can 

### be used on the day of mixing, 

### 00 not allow spray sofulion to stand ovornight 

### Do nol 

### spill the concentrated PfodUd on spray oquipmenl, or any airplane parts, 

### ANYSPfLl.S SHOULD BE RINSED IMMEDIATELYWfTH PLENlYOFWATER

.

• 5&of a nurse tank is highly recommended fOf Qyoiding 

### possible spills ofconconl!afGd formulation on spray equipment oranyairplane arts. TANK MIXTURES WlTH DEFOLIANTS AND INSECTICIDES PREP'"" brand Ethepi10n is compatible with OEF',**FOLEX~\** 

## DraW. Harvade3• Methyl Parathion, Guthion1

, and Malathion", PREp'Il.1 may b. applied In sequence or as a tank mixture (DO NOT TANK MIX WITH DESICCANTS IF COTrON IS TO BE SPtNDLE HARVESTED). Follow all applicable us. precautions and rato por acre rocommendatlons on labelsof productsapplied as tank mlX1Ures or In sequencewith PREP N brand Ethephon. In somo casas slight reduction In boll opening response has been observed when tank mixes with defoliants wore used. Good agitation In the spray tank is essential and a tank mixture should not be allowod to stand without agitation for mOfO than 5 to 10 minutes. Road and obslHVe all appropriate !abal \l$e directions and precautionsfor the defoliants and insectickfes u\4:.1. 

## • NOTE: Undo;CGrtain conditions, fank mbduro$ 01 PREpnI brand Ethophon with desiccants containing sodium cl1klrttl could!··:·: rosulr in theformafion ot hypochlorous acids which on heating will emit toxicchloride fumes. • •••• • • 

# ... EQUIPMENT CLEANlNG • 

## •••••• 

## • •



# .. BoC4uso of the acidic nature of this ploduCl, probnged exposure to spray deposit 

### will damage acrylic plastics;

### fJl.(tJIln**paj~!i**...lJfld metals. • ••: ••• Rinse thoroughly with a detergent and wator all exposod acrylic plastic-type materials (e.g., aircraft windshields),

# "'d' l>1dntoo surfa.os wllhln an hour after oxposure to spray deposits,

.... •
..... 

### • 

## •• At t,he end of .ach day, rinse thorou.ghly wilh a detergent and watar all the metal parts 01 tho aircralt and**t~e** '\sJlOciated $pt;ty eqUipment oxposoo to the spray deposits. ••• •••••• 

### •••• 

## • • • • • • 

## •



# ..**~~** 

# 60 •• ••

# COnON

USE



### PREpm 8011 Opener"

PREpDI 

### + 

### FOLEX· Oefollant Tank

Mix
Dropp2 

### Dafollant Tank

Mix**Pr.~Condltlon.r** 

### for Defoliation ..**~**....**~** 

# -

..

### -.-----.-....

### -

..**-~**



### EXPECTED CONDITIONS



### HoI: and

### dry OO-F

### or higher Dry and 75 to 8O'"F 

### Cool

### but above**65~F** 

### Rank cott'::n High soil moisture 0< High lortiflty lovol 0' 

### Rank cotton High soil moisture High fertility Iov91 Rank cotton 

### 1113
2 22/3



### 113

113



### Hot, dry. above aO°F 2J3 Cool, above ssoF 1 113 

### or Rank cotton 

### PREp1Y RATE 

# ILBS A.I. \.0
1.S 

### 2.0

0.25

0.25



### O.S .1.0 

### 6
4



### 24

24

12 6 SPRAY VOLUME (GalsJA) 

### APPLICATION TIMING

15

- 50

15- 50

10-50

15-50 

### AIr" Apply when tho number 

## ?f mature unopanod bolls,

# is sufficient to produco

### '~t~~ 2 - 5 desired crop. 880 

### below"uI 

### tost 

### 01 boll maturity, Treatment uniformly

### .~."''' bolls 710 14 days earlier.


### 5· 

### to Apply 

### 4 to 

### 7 days.**Pfio~** 

### to 

### PREptloE boll

.

:3 

### -10

2-5 application. To be

### us.od.~ 

### a**soq.u~~:!!1 tr.atmon~IW~;**  

### not In ",,:,,,,,,of PREpTU """

Apply 4 

### to 7 days prior to defoUant. Enhance.s-:op crop defoliation 

### i deterioration of**bottom_~,~~** and allows lor 

### ·Pretreatment With DelolIants Prior to PREPTM Boll Openfng Treatment Hthe cotton isoverly rank or laying 

### down in the middlesand good spray coverage 01 the 

### bolls with PREPTW Is difficult, a pretreatment with defoliantswill be usefulto improve boll covGrage with PREpn.!. Use dosage rates of PREPW 

### brand Ethephon recommendod for

# 00" opening. Read and ob$orve all,appropriate label use directions and precautions for the defoliant used. ulnCalifomla and Arizona use a volume of no l&ss than 5 gallons par acre for aerial applications. 

# _oIl Maturity A bo11 is mature when 

### it 1$ 

### too hard to bo dented when squ9(lZod betwerm thumb and fingers. too hard to be slicod with asharp knite, and when the Hodcoat bocomos light brown In color. 

### Use 

### LlmltatIons Do not exceod a maximum 012.0 lb. altAfor combinod uses of PREpN per acre peryear. Boll Opening: 

### Do not tank mix PAEp1'l4 brand Ethophon with a desiccant ifthe cotton isto 

### be spindle harvested. Pro-Condition for Defoliation: Do not lank mix PREpDI with desiccants unless plant desiccation Is required. 

### Do nol use a defoliant bofore thoro issullieiGnt mature unopened bolls to produce the desired yIeld (seo GonoraJ Inlormation section on 

### hpw to test for boli maturity. .:. WHEN TO HARVEST COnON •••• : •• :.: 

## • •• 

## • • Do not harvost cotton soonorthan 7 days after atroatmont with PREP"'

### brand Ethephon. ••• •••••• Observe the troaled crop and harvest whon optimum bollopening has beon reached. Too oarl), harvest might reduce die lull oov

...;t&O; 01 the treatment and too late a harvast may rasuH in reduced quality and lo$s 01 lintwhich will drop lrom thQ plant. : ••• :. • •••• 

### • • 

## • 

# ..." •••• 

## • • •

•••• •

## ••••• • • 

# • •• 

## • •• • • 

## • 

# ..... ,



## •••• • 

## • •

## • •• 

## • • • • •

•• 

# ..
61**--------~~-~----.~~~**



### PREp'nA Crop Situation Plnt./Acr.
Dir&C1ed Spray 

### Application

Over-The-Top Application 1113



### t11"3-2213

USE LfMITATIONS**50~50** 

# TOBACCO (Flue-Cured Only)

Use drop nozzles, 

### gpa al**35~40** 

### 2**nozzl~** 

### ...**~or**

### !·!",';,o"e:M 'he Spaclflc Dlractlons.

or OC spray tips doslgned to apply 

### 50 at tractor spoed 

### 01 2·3 mph.

side ofthe row dropped low rIpened and harvested, 

### a dirocted spray, 

### be sure to harvast 

### II
Treat only when loaves remaining on the stalk ate maturo. To remaining leavas ara mature, test spray several tobacco described undertho sectlon ·ProperTime ofTreatment.· Use the

### ~:~;;!::~

# I

a normally mature crop when experience Indicates that minimum inducemont is raquirod, Use the higher rate when the crop is heavy and a tendency to 

### be more rank 

### or when temperatures 

### am lower than normal. Always tost spray to detormine Ifthe tobacco is mature enough to respond to treatment**w~h** 

### PRE?n.! brand Ethephon. ov,,,.,h,.,op**PREP~** 

### brand Ett,epho"spray 

### asa fine mist using throe 'he 

### plant, andono 00

### oach

. to the 

### I

Do not apply PREPTJ.! brand Ethophon to Immature loavos as this can rosult in unsatisfactory coloring, wolght loss and roducod leaf quality. Do not allow the cropto over ripen in the fi&ld aftar using PREprw brand Ethephon. since this may cause some reduction in yiold and quality. 

### Do nottreat bGfor. anticipated majorslorm which could prevent harvest and rosult in crop loss, Do 

### not apply PREpni 

### brand Elhephon if 

### rain is expected within 4hours. 

### APPLICATION TIMING Succ&sslul results wHh PREpni call for treatmont when loaves are maturo, not overly rank green when sprayed. To oasUy dotermino tho propertreatmontliming and the numberof leaves per stalk roady for harvest, test spray several plants In more than one location In each lield and observethe response, Mature leaves will bogin to yellow In 24 

### to 72 

### hours. Test klaves that faUto yellow in 72 

### hours are not 

### matum and are not ready for PREpn.! brand 

### Ethephon treatment. Wait 

### a lew days to**porm~** 

### further natural maturing, then maks anolhertest spray or -maturity· chock

. 

### .rthenyou have conlirmad the numborat loaves per plant that will color, you can determine the number of acres to troat in order 

### to lill**~ebarn.** 

### Prepare yourtoat spray 

### by mixing ono teaspoon 

### 01 PREpn.! in t quart ofwater, Spray each tost plant with about 

### 1oz. of this mixture, covering aU loaVQs with afino mist. PREp!M brand Ethophon will 

### not colorimmature sprayed leaves, WHEN TO HARVEST AU mature, sprayod loaves will begin to colorwithin 24 to 

### 72 hours after PREp-n.! brand EthGphon application. Tho yellowing process 

### is weathor dopendem; cool weatherwill delay, while hot. sunny weather can speed up the process. HaMlsttroated tobacco when leaves have reached the deslrod color intensity. Do 

### not allowtobacro to 

### become over ripe bofore starting harvest. leaj drop

### can ooeurwhen tobacco is over ripe and left 

### on the stalk. H

## a numbaroftho bottom leavos have yollowed at tho time oltroatment, they should 

### be hruvesled priorto spraying 

### wi!. PREpn.! brand Ethephon, • • ••••• 

## •••• • 

# •• With an over-the·top application, harvesting can commence 24 hours aftor PREpn.! brand Ethophon application d.ptndipg on fleathef conditions orto avoid over ripa tobacco, Tobacco harvBstoo 24 

### hours aftertreatmentwill requite more time in tho

### oolO!ing**pha~1l'1t** 

### curing process. •• 

## • • CURING PREPN TREATED TOBACCO :..... ..:

.... Curing pmcedurGs are as much an art as ascience and each cure must

### toJUdged on the basis oftobacco**cond~k'!rI.**

### JQterval btlMII'n troatment and harvest. woather and typo of curing facility bofore prescription temperature and**ventilatio"If~,dules** 

### can 'be establlshed. To obtain maximum quality, care 

### must be taken to observo and 

### control the curing procenclosely, espqcially**du":~t,,<** 

### late**~coloring·** 

### and early**·drying~** 

### stages ofthe leaf. • _. 

## • •• PREpm brand Ethephon troatod tobacco wDl 

### havo started the coloring piOCO$$ 

### when harvested, redUCing the time**~r~** 

### in thl·:·-: colollng phll88 

### of

### curing. Treated tobacco 

### should be driGd faster. 

### II tobacco loaves are green orcontaIn somo groeO whqrl**harv6ltett~** 

### it may bo 

### nocessarytocolorthem for a

### few hours. 

### II tho loaves are rompletoly yenow, temperalure and 

### vanlilation**"'l.~tt** 

### adiustod in 

### a mannerto dry the tobacco as fast as possible without scalding. Once the leaf is dried (3/4

### dry), you should follow normal procedures for curing. Since pREP"" brand Ethephon treated leaves cure faster, treated and untreated loaves should not 

### be cured together in the same bam. 

# 62 

# ,..

# _--------------------_

.. 

# _ .. 

# --**~** 

### .--.....**~**



# LIMITED WARRANTY AND DISCLAIMER Tho manufacturerwarrants (a) that this 

### product conforms to the chemical d6scrlption on tho label; (b) that this 

### product is reasonably lit 

### for tho purposes sot forth In tho dirocllons for use whon 

### it is used In accordance with such dlrGCtions; and (c) that the directions, waming and other statemonts on this label are based upon rosponslblo experts' evaluation 

### of reasonable tests of effoctivonoss, of toxicity to laboratory animals and 

### to plants. and 

### of reslduoa on food crops and upon reports 

### offloklexporience. Tests havo not beon 

### made on aU vanalles Of 

### in 

### all stalGs Of

### under

### aUconditions. 

### THE MANUFACTURER 

### NEITHER MAKES NOR INTENDS, NOR DOES rr 

### AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE, ANY OTHER WARRANTIES, EXPRESS OR IMPLIED, AND IT EXPRESSLY EXCLUDES AND DISCLAIMSALL IMPLIEDWARRANTIES OF MERCHANT-ABILllYOR FIlNESS FORAPARTICULAR PURPOSE, THIS WARRANlY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANYAND ALL LOSS OR DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENTWITH THE LABEL DIRECTIONS, WARNINGS OR CAlITJONS. BUYER'S EXClUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, LOSSES, DAMAGES, OR INJURIES RESULTING FROMTHE USE OR HANDLINGOFTHIS PRODUCT, WHETIlEROR NOT BASED IN CONTRACT, NEGlIGENCE, STRICT LIABILITY IN TORTOROTHERWISE SHALl BE LIMITED, ATTHE MANUFACTURER'SOPTION, TO REPLACEMENTOF, OR THE REPAYMENTOF THE PURCHASE PRICE FOR, THE QUANTITYOF PROOUCTWITH RESPECTTO WHICH DAMAGES ARE CLAIMEO. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR 

### SPECIAL, INDIRECT OR 

### CONSEOUENTIALDAMAGES RESULTING FROM THE USE OR HANDLINGOFTHIS PRODUCT. NOTICE TO BUYER Purchaso of this product doas not confor any rights under pationts govorning this product ortho usa theronf in countries outsido altho United Statos

.

• OEF 

### and Guthion aro registered IradGlllarks 

### of BayerAG, Germany. 

### 20ropp 

### is II regi$torod tradornark 

### ofNOR·AM Chemical Company. 3Harvade 

### is a registered tradomark 01 Uniroyal Company. 4Malaihion is atradomarkof American Cyanamid Company,



# •

RhOne-Pouienc Ag Company 

### P.O. Box 

### 1201.1.. 2T.W. Aloxandor Orive ResearchTriangle Park, 

### North Carolina 27709 

### PREP 

### is the 1rademark 

### of Rh6ne-Pouklnc. FQLEX 

### is a registered trademark 

### of Rhbno·Poulonc. 

### PREpnt brand Elhophon for Cotton and Tobacco (MASTER) NotiJicallon **619/93.** 

### • 

# ...

•


# ..... • 

## • 

# •



# .. • • 

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• Mr. Warren A. Davis Rhone-Poulenc Ag company P.O. Box 12014, 2 T.W. Alexander Drive Research Triangle Park, NC 27709 Dear Mr. Davis: Subject: Skin Irritation study (MRID 

## # 428727-01) PREP Ethephon Cotton Boll Opener**~~** 

## EPA Registration No. 264-418 ,

## ~ Your Submission Dated August 5,

## 19~ This will acknowledge receipt of the subject study. vIe 

### are 

## not reviewing it 

## at this time since the summary of the data indicates that this study t>lill not change the toxicity category of 

### the subject product. 

## Sincerely yours, 

# /5/ cynthia Giles-Parker Product Hanger (22) Fungicide Herbicide Branch Registration Division (H7505C)



# 64

### -ntis

# ~ One copy of the '(I'PC di.a.gnosis .and 

### one of the aMOQted**~i.bl.i.ogeaphy** 

### are prG1t.:tde3 

### for**~ £lles~**  

### Lhe ppC 

### It.as .already oaUed <out 

### the. subcd:t:te.r"$**eopi.~** 

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### is 

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### hiDll.ogn.phy (if oappliccllleJ :are

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• U.S. ENVIRONMENTAL PROTECTION AGENCY Office of Pesticide programs

RHONE POULENC AG CO. P.O. BOX 12014 

## 2 T.W. ALEXANDER DRIVE RESEARCH TRI. PARK, Ne 27709 

## Report of Analysis for Compliance with PR Notice 86-5 Thank you for your transmittal of 08/06/93. Our staff 

# AUG \ I 1993

has completed a preliminary analysis of the material. The results are provided as follows:



## Your submittal was found to be in full compliance with the standards for submission of data contained in PR Notice 86-5. A copy of your bibliography is enclosed, 

## annotated with Master Record lOts 

## (MRIDs) assigned to each document submitted. Please use these numbers in 

## all future references to these documents. Thank you for your cooperation. If 

## you have any questions concerning this data submission, please raise them with the cognizant Product Manager, to whom the data have been released

.



# 66

# ~ **RHONE-POULENC**



# • RHONE·POULENCAG COMPANY ETH 93-21 

## August5 ,1993


## U. S. EnvironmentalProtectionAgency OfficeofPesticideProgram DocumentProcessingDesk 

## Room266A,CrystalMallNo.2 1921 JeffersonDavis

## Highway Arlington,Virginia

## 22202 Attention;Ms.CynthiaGiles-Parker ProductManager(22) FungicideHerbicideBranch Registration Division (H750SC)

Dear Ms. 

## Parker:
RE: PREP®BrandEthephonCottonBoll Opener EPAReg. No. 264-418 428727-

# 1'>cj)

Appendedare3 copiesofa recentlycompleteddermal inilation studyforPREP®. Theresults indicatethatPREP®isa categoryII dermalirritant. Thisdata should bemadepartofthefile forPREPandanMRlD numberassignedfor futurereference. Ifyouhave anyquestions 

## pleasecontactme. 

# • Sincerely,

# .w~AJ)awA. Warren A. Davis SeniorRegistration Manager

POBOX 1201".21'" ALD.ANO(R i::AI\lF R(SfARCHTR!ANGl£PARK.

### nc ?l

### un (919)542-2000 INTEANAT!ONAt. tELEX NUMBER**~9983lB-** AN$','.,[I,u;,cKIJ>CflTP Im(RNAnOl'JN DISWllBUilON SER'.'IC"$lllfxNUI.1GU'49VJ$77- M.$'

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### illAchlevemonl 

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•**Rhone~Poulenc** 

### AgCompany



## TRANSMITTAL BIBLIOGRAPHY

1. 

## Douds,D. July 13, 1993. A preliminarySkinIrritation Studyin Rabbits with PREP brand Ethephon Cotton BoH Opener, Conducted 

## by Springborn Laboratories, Inc. 41 pages.



# .

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# 68

## - - - - -

-- - ----

## ------ -"


## --

-- -" -,

## -- --

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## ------- " 

## --

## ---------
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 

### 20460



## Mr. Warren 

## A. Davis Senior Registration Manager Rhone-Poulenc Ag company 

## P.O. Box 12014 2 T.lL 

## Alexander Drive OfFICE or I'REVENTION. ffsnCIOES ANO TOXIC suaSTANCES



## Research Triangle Park, NC 27709 Subject: Alternate Confidential statements of Formulation Prep® Brand plant Regulator EPA Reg. No. 264-418 Your Letter Dated 01/30/93

Dear Mr. Davis: According to our records, the source product (EPA Reg. No. 264-276) for the basic formulation of Prep® Brand Plant Regulator (EPA Reg. No. 264-418) was canceled on 01/22/91. The source product used for the alternate formulation is EPA Reg. No. 264- 511. Before the alternate formulation can be accepted, the source product of the basic 

## formulation must be corrected. Sincerely yours,

-nthia Giles-Parker Product Manager (22) Fungicide-Herbicide Branch Registration Division (H7505C)



# ..**!:l1.:;'[,.~...**

# ............................................................................................................................................................................ SURNAME. 

# 1.

# kv"";' 

# or/J;,ki

.........................................................................., .....................................................................................................'

................. DAT6 EPA Fo,m 1320·1A 11/90) FILE c;opy 

# 69

## --

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## ,



# •

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PROM:
THRU: 

### PRODUcr CHEMISTRY


## PM 

# e?';{ I. 

# Ill.s-h"

CHEMICAL:_-

_____ _ REG. NO: 

# ,;Ue1-'1Af' ALE SYMBOL:

___ _

REVIEW fOR END USE PRODUcrS
PRODUcr NAMES:

# 4,. ;>k"J. j(7"'J,,!.

# J.

.. For 

# e.+fo '1**~** 

### NOS.

___________________________________ _ Food U.e

_____________ _ Non Food Use

__________ _ Inens cleared: c ( ) d () e ( ) yes () no ()
lnens List I ( ) Other ( )
Please provide the requested infonnation for 

## the following checked items:

1. 

# [J SubmJt the product specific product chemistI)' data for your product. { I if submJtted earlier, provide**~** 

### Nurnber(s). {' Your product is 

### not sufficiently similar to the product your referenced.
2. 

## In 

## reference to the Confidential Statement of Fonnula (CSF), pi.... provide the (ollowing: 

# [J a) pH of product at a specified water dilution. (1 b) Density 

### ofproduct. 

# ( J c) 

## Flash point ofproduct.

[1 d) 

## F1ash point ofproduct with propellent as 

## per item #6(q) or item 

### #5(c).

### 3. 

## .2·

(J f) 

### The 

## upper and 

### lower ce!tilled limits based on the pure active ingredients 

## rather than the 

## teChnical or concentrate, [) g) 

### The upper and lower ce!tilled limits of the individually added inerts. (I h) 

### [J i) 

### (J j)


### Based on the 

### cwrent CSF dated,

__ -",

___ ,-_' your product 

## wUl not meet the 

### label claim 

### for the 

### active ingredient. Please revise the 

### label or the 

### CSF so 

### tl1lI1 the 

## infonnation 

## agrees.
4. Provide the 

## chemlcal identify of 

### all components. 

## the percentage cOmp05lllon. CAS 

### Registry Number. and Material Safety Oat. Sheet (two copies) for the 

### following 

## compounds:
L


## 2.
3.
4.


### 5.



### The supplier may contact 

## BPA diIectly refe"mcing the 

### Pile Symbol of 

## BPA Registration Number in their 

## response. For dyes. provide the 

### color 

## indea and 

### CAS Registry Numbers for 

### all components. For perfumes 

## and flavorings. provided for each 

### componeru in the 

### mix"",,: the chemical name. CAS Registry Number. and the 

### percentage or range in percentage in the 

### mixnm:. Certify 

### that flavors are non·food type. 

### The Confidential information submitted 

## by the suppliers is kept 

### confidential under FlFRA Section 10.
5. 

## In the proposed labeling. provide the following information: [J 

### a) Update the 

### label Storage and 

### Pesticide and Comainer Disposal 

### Statements in accordance 

## with [ ] PR Notice 84-1 for**non~aerosol** 

### containers for houses 

### and institutional uaes of [ 

# JPR Notice 83-3 for all other 

## we•.



# 71 

# •

•

# •

• -3- [J 

### b) Add the 

### heading PHYSICAL OR CHEMICAL HAZARDS to the 

### label and the 

### appropriate statement per 40 CFR l56.10(h)(2)(iii). [J 

### c) Under the heading PHYSICAL OR CHEMICAL HAZARDS, list

### the 

### product 

## as extremely Flammable (because your product contains flammable propellents). 

## (] d) Provide 

## that the 

## solvent does not have insecticidal acuvlty, 

## it should 

## be removed from the ingredient statement active ingredient listing and 

## the percentage added 

## to the inert ingredients. 

## If the solvent has insecticidal .properties. provide the EPA Registration Number. [J 

## eJ Add, footnote to the inen ingredients indicating: Contains

[J f) 

## Since your data matrix does not provide a&electrical breakdown voltage, you 

## must add the 

## following statement to 

## the physical or Chemical Hazards heading;


### Do 

## not use 

## this product in 

## or on electrical equipment due to the possibility 

### of shock .hazard. [J 

### g) The 

### terms active ingredient(s) and inen ingredients should 

## be in the same type 

### size, 

## be aligned to the 

### same margin and he 

## equally prominent. [J h) 

# [J i)


### 6. In 

### reterence to the product 

### specific data 

### requirements, provide the 

### following 

## information: [1 a) Statement of Composition: A complete description of the 

### manufacturing 

## fonnulation process. Describe 

## equipment used, mixing 

## time, temperature, pressure, etc. 

### [J 

### b) Discussion ofFormation ofUniotentiona1 Ingredients: A brief description of impurities 

### formed during the manufacturing/formulation process, 

## inpackaging 

## or during 

## storage. If

## you do not expect any impuritics during these stages. please so state. [J 

### c) Cenification of Limits: Upper and lower limits or each active and 

### indivtdually 

## added inen 

## component.



# 72

# [J d) Analytical Method: Provide the methods used to analyze 

## for the 

## active ingredients or a 

## full reference for a published method or 

## MRlD Number(s) 

# (J e) 

### Color: 

### In common terms. 

## [] 0 Physical State: e.g., solid. liquid, pressurized liquid, etc. (] g) 

### Odor: 

## In common terms [J h) 

## Density: e.g., Ibs/gallon for liquids or lbs/cu.ft for solids. 

# [J i) 

## Ph: Provide pH of product or pH of a 

## specified water dilution. [1 j) 

## Oxidizing or Reducing Action: Note these 

## characteristics, if

## any. [J k) 

## Explodability: Note these characteristics, if

## any. [1 1) 

## Viscosity: Can 

## be expressed in centipoise or cenristoke. [J m) 

## Miscibility: Note these 

## characteristics if

## product 

## is an 

## emulsifiable Iiqujd 

## and mixed 

## with oil. 

### [J 

## n) Corrosion Charo:teristic.s: This 

## information 

## can be noted during the 

## storage stability study. [1 0) 

## [1 p) 

## Dielectric Breakdown Voltage: For products used near electrical 

## equipment. Storage Stability: The 

## fonnulated product 

## inust be analyzed 

## for its acctve ingredients at time 

## zero and during 

## one yeat ofstonage, The 

## stonage abeuld be at 

## warehouse conditions 

## of temperature and 

## humidity and 

## stored in the 

## product's 

## cornmerciaJ package. Note: Por the 

## storage 

## stability study, 

## you may 

## not reference the data 

## on source 

## product concentrate you are using to fonnulate your product. 

### [J 

## q) Flamrnabi1ity: Flash point/Harne extension. The 

## Hash point reported exceeds the 

## one expected 

## for this 

## product. 

# Pl.... check and 

## resubmit. 

## Misn=s tna!l<eted 

## under pressure, including those conraining hydrocarboos, 

## are subject in their 

## entirety to tests indicated in 40 CPR Section l56.JO(hX2)(ili) ofthe maxlpacl:age. 

## Note that 

## Hash points for pressurized liquid from the 

## contain<r 

# [J If

## any ofthe 

## items are not applicable, write N.A. and explain ressons are specified 

## under chemistry data requirements footnotes. See 40 CPR Pan 158.



# 73 

# •

•

# •

• -5-
7. 

# [J The following is 

### the 

## regulatory 

## slatus of the 

## men ingredients 

## Wlder 40 CFR 180.1001 for for 

## the exemption of the requirement of a 

## tolerance.


## 8. Other



## Note 10 

## PM: Inter-office use only



## SUMMARY ATIACHED



# 74

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# 75

### DP BARCODE:**D~88188** 

### CASE: 003396 DATA PACKAGE RECORD DATE: 02/17/93 SUBMISSION: S435392 BEAN SHEET 

### page 1 

### of 1 

# * * * CASE/SUBMISSION INFORMATION 

# * 

# * 

# *
CASE TYPE: REGISTRATION CHEMICALS: 099801 Ethephon ACTION: 345 TECH-FORMULA CHANGE AMND

10': 000264-00418 PREP PLANT REGULATOR COMPANY: 000264 RHONE-POULENC AG COMPANY PRODUCT MANAGER: 22 CYNTHIA GILES-PARKER PM TEAM REVIEWER: CLARENCE LEWIS RECEIVED DATE: 02/09/93 DUE OUT DATE: FOR COTTON 703-305-5540 703-305-6117 05/10/93 

# * * 

# * DATA PACKAGE INFORMATION 

# * * *
DP BARCODE: 188188 EXPEDITE: N DATE SENT: 02/17/93

.... EMICAL: 099801 Ethephon



## TYPE: 001 Submission Related Data Package ADMIN DUE DATE: 04/03/93 CSF: Y ASSIGNED TO DATE IN OAT!: OUT DIV : RD 

## / / / / BRAN: RSB 

## / / / 

## / SECT: PCRS 

## / / / / REVR : 

## / / / / CONTR: 

## / / / / 

# * * * DATA REVIEW INSTRUCTIONS 

# * * * ROOM: CM2 ROOM: CM2



### DATE RET.:

LABEL: Y



## Attached for your review and comment is Rhone-Poulenc's letter of 1/30/93 

### & alternate CSF dated 2/1/93.



# * * 

# * ADDITIONAL DATA PACKAGES FOR THIS SUBMISSION 

## * 

# * *

• DP BC BRANCH/SECTION DATE OUT DUE BACK INS CSF LABEL 55.4000%



## / 229

261



## /



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# 82

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# (

iIIl' RHONE-POULENC**\,~** on %'



# • RHONE.POULENC AG COMPANY 

## Eth 93-13 April 13, 1993


## U. S. Envirorunental Protection Agency Office ofPesticideProgram DocumentProcessing Desk Room 266 A, Crystal Mall No.2 1921 Jefferson DavisHighway Arlington, Virginia22202 Attention: Ms. Cynthia Giles-Parker 

## ProductManager(22) 

## FungicideHerbicideBranch Registration Division (H7505C)
RE: YourApproval datedApril 

## 5, 1993 PREP EthephonCotton Boll Opener EPA 

## Reg No.264-418

• I 

## DearMs. Parker

# 1£;:::::-~~'"'-"" As requested weare submittingonecopy ffinallabelinj!.for PREPCottonBoll Opener. 

## We appreciate your assistancein approving
.**~endment** 

## in **time** 

## for 1993 sales. 

# •

Sincerely,

# ~~/f'.

# /:bc';" Warren A. Davis Senior Registration Manager

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## • • •• Fxceiicnce**in·Pc-riormi1::~;e** 

# 83LABEL INFORMATION PAGE 

# PREpTM brand Ethephon for Cotton and Tobacco 

# MASTER LABEL
Routing: Product Development Product Manager State Registrations

• Registration Manager



# • General label revisions:
• Revised the cotton tank mixture 

## u/d and added to General Information section the paragraph (Tank

mixtures with Defoliants and 

### Insecticides). 

# Rate changes for the following: CA restrictions: Printing Restrictions:

•

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# ., ., 

# 84

# ETHEPHON FOR COTTON AND TOBACCO
For Commercial Use Or Agricultural Use Only. Not For Residential Use ACTIVE INGREDIENT: Elhephon (2-Chloroethyl) phosphonic acid' ."

.....................................................55.4% 

### INERT INGREDIENTS: ...........................•....•..........................................................................................44.6% "ThiS prOduct 

### contains 6 pounds elhephon pergallon, EPA Reg. No.**264~418** 

### EPA Est. No.**264~PA-01** 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO
PRECAUCION

### At. USUARlO: Sl us!od no 100 inglo$, no usa 6sl0 produClo hasta quo la informacion on 

### ta otiquota 10 haya sido oxplicado 

# ,.

usos t 

### • 188

## :;~';4·:2'O:~,9: licensQ is glantod to use this in countries other than tho for any

• usa not contemplatod by this liability for palent infringoment may rosuh from use or sale of this product outside tho United 

### Statas.



# • STATEMENT OF PRACTICAL TREATMENT IF IN EYES: Hold eyolids op<ln and flush**w~h** a gentle straam 01 water tor at teast 15 minutes. Get medical attantion, proterably an ophthatmologist IF ON SKIN: Immediatety wash skin with ptenty 01 soap and wat0r. Remove contaminatod clothing and shoos. Wash clothing separately boloro rGU$o. IF

### SWAUOWED: 00not induCQ vomitIng. Promptly drink a targo quantity 01 milk. egg whites, gotatin solulion or il these are not availabhl. drink large quantities 01 water. Avoid alcohol. Call a physician immediately. IF INHALED: Remove victim to Iresh air. Hnot breathing, give artificial respiration. Administer oxygen if neCQssary. Got modicat atlention. 

## PRECAUTIONARY STATEMENTS DANGER HAZARDS TO HUMANS AND DOMESTIC ANIMALS CORROSIVE. Causes O1e and $kin damago. 

### May be latal ifabsorbGd through skin. Harmlulll swallowod or inhaled. Avoid breathing spray mist 00 not got in eyos, on skin orondothing. Wear full length trous(lrs, 

### long sleovod shirt, protective gloves, and goggtos or laceshioidwhen handling. Change to clean work dothesdaily. Wash thotoughlywith soap and water aftor handflng and beforo eating, orsmoking. Removo and wash contamInated clothing belore reuse. Koep away from domestic animals. NOTE TO PHYSICIAN Thoro is no $p&Cifk: antidote. AUtreatment shoutd be based on observed signs and symptoms of distress in tho patient Ovoro:.:posure to materiats other than this product may have OCCUlTed. Victims of sovero OVGrexposura, by inhalation, should be kopt undor**m~ical** observation lorup to 72 hoursfor detayod onset ot pulmonaf)' edoma. In a victim 01 ovar-oxprniuro by ingestion, catolul gastric lavage is required due to the possibility ofstomach or esophageal perforation. ThIs material is an. acid, but use 01 alkaline substances to neutralize it is contraindicated, 

## ENVIRONMENTAL HAZARDS 

## •••• • Do

### not apply diroot/y to water. to areas whero surfacewater is present orto intertidat areas betow**the1"~ ~igh**  w4Mtnark. contaminate water whon disposing 01 equipmont washwators. • •• • 

## • • Do not contaminate water usod lor irrigation ordomestic purposes. • ••••• 

## USE PRECAUTIONS • • • •



# .. ••••• 

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# .. . Do not apply PREPTl4 brand Ethephon through anytypo of irrigation system. 

# •• • 00

# 00'

Avoid spray drift to nearby crops as this prodUCl will causa modifications in plant growth. 00 not plant anothercrop within 30daysaltortreatment. Planl injuJ)fMfd!:lucod wald;will rosult.


### Mix only the amount of spray you expect to usa each day. Do not allow mi:.:ed sotution to stand overnight. 

## NOT REVIEIlED In Aoool'don•• with PR Notice 82-2, 

## BeIIe4 OIl Draft Labeling Dated ;/. ,,' " 

## •• 

## • •••• 

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•• ••


# 85**~---~~~**...**-~- ~** 

# • DIRECTIONS FOR USE It Is a vIolation of Fodoral law to ua. this product In a mannof InconsIstent with Its labeling. 

### Road antira labol bofot. using this product. 

## REENTRY STATEMENT Mixers, loaders and applicators must woar a luU face shield, langtrouSGrs, 

### long sloovOO shin, glovos and boots to avoid as much skin and eyo contact as possible. 

### Do notenter treatod fields within 24 hours aftor application unloss protective clofhing is worn.

Do not contaminate walsr, load, orfood by storago ordisposal. If 

### container is brokon oroontonts have spillad. follow an 

### procautions indicatod above 

### and ctoan up immodiatoty. 80lorodoaning up, 

### '"II**I<,,~th** trousers, 

### long sleoved shirt. protective gIoV8S. and gogglosorface shiotd. Soak up spill with absorbont modia such la

... nd" •• uth orothor suitablo malarial and disposo 01 waste at an approved waste disposal facility. PESTiCIDE DtSPO$Al Pesticido wastes are acutely hazardous. Impropordlsposalol excess pesticide, spray mixturo. or rinsate 

### is a violation of Foderal law, wastG. cannot 

### be disposod 01 by uso 

### accordillg fO tabol instructions. contact your StOlto Posticide or Environmental Control

### j~~~:;;,~~,tt:h;~eHazardous Waslo reptesontativo al tho neOlre!t EPA Regional Oflico lorguidance.
i Then ollorfor Ii i ,


## GENERAL INFORMATION COTTON t il an<j dlop''''' 01 in a sanital)'

A totiar spray 01 PREpn.r brand Ethepnon will 8CCiIloralo opening 01 maturo unopened collon bolls and enhance dolotialion which can rosolt In oartior harvest with an incro4sod rocoverablG yield. PAEpn! brand Ethophon treatmont on cotton allowsiocroasod oltlcioncy from 4 once-over harves!. TOBACCO (FlUe-CURED): A loliar spray of PAEpn.r brand Ethophon promotes early, uniform 8 yollowing8 of mature tobacco. PREPN roducQS curing time, allowing moro officiont use 01 curing barn spaca, and incroased conlrol ovor harvost schedules. SPRAY PREPARATiON Add t/2to 314 ofthe roquirGd amount 

### of wotor to tho spray tank. Start agitation. Add the required amount 01 PAEprw brand Ethophon, and the romaining amount of wator. Propare only as much spray solution as can bo usod on the day 01 mixing, 

### Do not allow spray solution to stand overnight. 00 notspilt the concentrated product on $pray equipmont, or any airplane paris. ANY SPilLSSHOULD BERINSED IMMEDIATELYWfTH PLENTYOFWATER Use 01 a nurse tank is highly rocommendod for avoiding possible spitls 01 concentrated formulation on spray equipment or any airplane parts. TANK MIXTURES WITH DEFOLIANTS AND INSECTICIDES PREprw brand Ethephon is compatible with OEF1

, FOLEX*', DroW, Harvado3• Methyl Parathion. GUlhionr, and**Malathion~.** PREPlM may b. appliod in soquenco or as a tank mixture (DO NOT TANK MIX WITH DESICCANTS IF COnON IS TO BE SPINDLE HARVESTED). Follow an applicablo use precal1fions 

### and rate poracro recommendations on !abols 01 products applied as tank mlxturos or in soquenco with PREP tLI brand Ethophon, In soma cases slight roouction in bolloponing rosponse has beon observed when tank mixoswith deloliants were uslKf. Good agitation in the spray tank is essential and a tank mixture should nol

### be allowed 

### to stand without agitation lormore than 5 to to minutes. Read and obslUVe all appropriate labot use directions and procalltions for tho defoliants and Insecticides used. NOTE: Undor CGrtain conditions, fank mIxtures of PREpw brand Efhaphon with desiccants containing sodium chlorate could result in the lormation 

### of hypochlorous acids which on heating 

### witt emit toxic chloride lumos. • ••• EaUfPMENT CLEANING

...... ..:. 

# • •• Because of lhe acidic nature 01 this product, prolonged exposure to spray depoSI! will damage a1:rylrc**~Ia$tics.** clrtain paints, and metals. •••••• : •••:. 

## " 

# . Rinse thoroughly with a datergant and water aU exposed acrytic plastic-typa materials (e.g., aircralt wirtq,sJlfotds).**~.Qainted** surfaces within an hour after exposure to spray deposits. ., •• •
..' : At the end of oach day, rinso thoroughty with a detergent and water all the metal parts of the**ai~rad** and tho aSSOciated spray equipment exposed to the spray deposits. ••••• .,. 

## •• 

## •



## •••• 

# • • 

# . " 

## •••• 

# 86

# • cortON

USE



### PREP1\( Bol/ Opener

### PREpm + 

### FOLEXCI 

### Oefollanl Tank

Mix

u;;.r 

### Dropp2 

### oofollant Tank

Mix



### Pr.-Condltloner for DefoUation 

## EXPECTED CONDITIONS



### Hot anddry SOGF Of hIgher 

### Dry and 

### 7510 SOGF Cool

### but abovo

### 65°F or ! Rook conon 

### High soil rnojsJuro or 

### High lertiJity Jevel or

. Rank conon High soil moisturo High fortility love' 

### Rank cotton 1 1/3


### 2 22/3

1/3

1/3

Hot, dry, above 80°F 2J3 Cool, 

### abovo 65GF I 

### V3 or Rank cotton 

### PREP'!)ot 

## RATE ONE GALLON**PREP~** 

# ILBS A.I. Acr•• 1.0
1.5 2.0

0.25

0.25

0.5 1.0 

### 5

4 3



### 24

24

12 6 SPRAY VOLUME (Gals/A)



### Air"

15·50 2-5

15 -50 

### 5· 10



### to -SO

15 ·50 2 -5 

### APPLICATION TiMING



### Apply when Iho number 0/ 

### rna/ur. unopened bolls is 

### sullicient to produco Ihe dosired crop. See below lor 

### lost of boll maturlty. Troatment uniformly opons bol/a 710 14days owlier.



### Apply 4 10 7 days**prio,.:~** deloHant. Enhances**~Ul'** 

### crop deloliatlon I 

### deterioration 01**bot1om_:;:c:~** and al/ows lor earlier 

### ·Pretreatment With Defoliants prior to PREP"" Boll Opening Treatment litho cotton is overly rank or laying down in the middle. and good spray covorago 01 the bolls with PREpnt is dillicult. a pretreatmont with deloHants willbe usefulto Improve bollcoverage with PAEpnI. Usedosago rates 01 PREpm brand Ethephon rocommandod for boll opening. Road and ohsoNa aU appropriate label usediroctions and precautions lor the defoliant used. ··In CaUfornia and Arizona use a volume 01 no loss than 5 gallons per acro for aerial applications. 

### Boll Maturity A ban 

### is maturo when it is too hard to bedented when squoozed botween thumb and tingers. too hard to be sliced with a sharp knife, and when the 

### $God coat becomes light brown in color. 

### use Limitations 00 not axcoed a maximum 012.0 lb. aliA lorcombined uses ot PAEpnr pGr acre par year. BoU Opening: 

### Do not tank mix PREpm brand Ethephcnwith a desiccant ifthe collon isto bospindle harvested, Pro..condition tor DoloUatien: Do not tank mix PREpntwith dos.icc;:mts unless plant desiccation is required. Do not usa a doloHant helorethere is suHiciont mature unopenod bails to produco the desired yield (see General Information section on howtotest lorboR maturity. WHEN TO HARVEST COTTON Do not harvest cotton sOOnG{ than 7 days attora treatmentwith PREpm brand Ethophon. • ••• Observe thotroated crop and harvosl whon optimum bellopening has

### boGn roached. Too early hzweJlto"'!9ht retl"H.tho tun advantage 01 the treatment and too lato a haNest may result In reduced quality and loss oflint which win drop lKJmlh.plant • 

### • • ••••••



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# 87

# • PREpTW Crop Situation Pinta/Acre
Directed 

### Spray Application

OVer-The-Top Application

USE LIMITATIONS 11/3

t tl3-22rJ 

# so40-60 

# tOBAcco (Flue-Cured Only)

Speclllc D"octlon&
Us. drop naulas. Choose TG or OC spray tips designed to apply 

### 50

- 60 at 

### 35-40 psi and at tractor speed of 

### 2·3 mph. Use 

# 2"'0""." P''' row;onaon each side oftho rowdroppod low enough 

### to dirQct tho the laavo$ to 

### be ripened and harVested. Thorough spray euenllal. Wifh 

### a directed spray. be sure to harvest aU loaves
Troat only when loaves remaining on the stalk; are mature. To ensu(O romainlng loavas are mature, test spray sevoral tobacco plants as described underthe section**~Proper** Time of Trealment.**~** Use the Iowor rate in a normally mature cropwhon experience indieatos that minimum riptlning inducoment 

### Is required. Use the higher rate wOOn tho crop is heavy and has 

### a tendency to bq more rank or when temperatures are lower than normal. Always tost spray to determine if the tobacco is mature enough to respond to treatment with PREP1"\( brand Ethaphon. Apply ovar-ltle-lOp PREp'Ilol brand nozzlos (ono noulo tips over the so all leav05 aro coverod 

### as a fine mist using threw

, and on each Side) tho i 01 i.

o 

### Do not apply PREpni brand Ethophon to immature loavos as this can result in unsatisfactory coloring, woight loss and reduced loal

quality.

o 

### 00 notallow the crop to ovar ripen 

### in lho field after using PREpni brand Ethephon. sinco this may cause some reduction in yield and

quality, 

### • Do nottreat boloro antlcipaled major 

### storm which could prQvent harvest and rosult in crop loss.

o 

### Do not 

### apply PAEprw brand Ethaphon if rain 

### is expQCIed within 4 hours. 

### APPliCATION TIMING SlJC(:OSsfuf results. with PREPni call for treatmonf whon loavos .ora mature, not ovarly rank green when sprayod. To easily detormlno tho propor treatmant timing and the numborof leavas par stalk ready for harvest, tost spray sovaral plants in 

### more than one location in oach field 

### and observe the response. Mature leavos will begin toyellow in

### 24to 

### 72 hours. Test leaves that fail to yellow in 

### 72 hours are not mature and are not**r~ady** for PREpN 

### brand Efhephon froatmont.**Wa~** a lew days to**perm~** further natural mafuring, then make another tost spray or**~malurity~** check, Whon you have confitmod tho numbor 01 leaves par plant that will color, you can determine the numbor of acres 10 treat in order to liU the barn. Preparo yourtost spray by mixing ono teaspoon of PREPrn in t quart ofwator. Spray each test p1ant with about t oz, of this mi){turo, coyering allieavos with 

### afino mist. PREpm brand Ethophon will not color immature sprayed loaves, WHEN TO HARVEST All mature, sprayod leavQS will bogin to color within24 to 72 haUlS afler PREpnl brand Ethophon applicslion, Tho yenowlng process is weather dopendent; cool weatherwill delay.while hot, sunny weather canspeed up the process. Harvest treated tobacco when loavos have roached the desired color Intensity, 00 not allowtobacro to 

### b&come ovor ripG btlfore sfarling harvost. Leal dropcan occurwhen tobacco is ovor ripe and left on the stalk, If a number of the bottom loavl'ls have yQllowod at the time of treatment, thoy should be harvostod prior to spraying with PREpn< brand Elhephon. With an over.thfi)otop application, harvesting can 

### commenct1 24 hours alter PREptu brand Ethephon applicafion depending on wGalhQr conditions or

### to avoid over ripe tobacco. Tobacco harvested 24 hours after treatment will require more time intho cpel'ing phase ollhn curing proCGS$. :

..:.: •••• CURING PREJmI TREATED TOBACCO : .: • Curing procedures ant as much an art as a scienco and each cUle 

### must bo judged on tho basis**of..~ conOUiP~** V'ItervaJ bOlwoon traatmont and harvest. weather and type 01 curing facility bofore proscription temporatUlO sri! V!tntllatibn schedulas can bo osiablished. To obtain 

### maximum quality, cartt 

### musl be- taken to observe and controf the curing proces, c!osely",·e:pttciaJIy during Ihe late**~colorjng·** and early**~dryjng·** SlagGS oftho loaf. ..:..• ••• PAEpN bfand Efhephon Iroatodtobacco 

### will have started tho coloring processwhen harvaSlQd, reQ101&1I9 the time**r~uirod** in tho coloring phase 01 curing. Treated tobacco should bo driedfaster. 

### Iftobacco loaves are graen or contain some**~a.t1 ~en**  harvested, it may 

### be necassary to color thom for afaw hours. If Iho 103Ve$ a.re completely yellow, tomperature and ventilalioltfltl.fSt 

### be adjustod 

### in a mannorto drytho tobacco asfast as possible without scalding. Oncotho mat 

### Is dried (314 dry), you should foRpw I}Olfnai proceduros for curing. Since PREpm brand Ethephon treated i&avos cura fastor, traated and untreated leavos should not bOUlrecttogether in lho samabam. 

# 88

## ------


# LIMITED WARRANTY AND DISCLAIMER Tho manufacturorwarranls (a) Ihat this prodUCI conforms to tho chomical doscription ontho labol; (b) that this product Is roaoonably**I~** for tho purposos sat lorth in the directions for use whon 

### it Is used in accordance with such directions; and (e) that Iho directions, warning and other slatemen!s on this label ate bMOO upon responsible experts' evaluation 01 reasonable tests 01 effectiveness. 01 

### toxicity to laboratory animals and to plants. and of residues on food c:rops 

### and upon roports 01 field oxporioncQ. Tosts haV8 not boon made on all varietios or In all statos or under aU conditions. THE 

### MANUFACTURER NEITHER MAKES NOR INTENDS. NOR DOES IT AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES. EXPRESS OR IMPLIED. AND IT 

### EXPRESSLYEXCLUDES AND DISCLAIMS ALL IMPLIED WARRANTIES OF MERCHANT·ABllITYOR FITNESS FOR APARTICULAR PURPOSE. THIS WARRANlY DOES NOT EXTEND TO, AND Tl-IE BUYER SHAlL BE SOLELY RESPONSIBLE FOR. ANY AND ALL LOSS OR DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITl-I THE LABEL 

### DIRECTIONS. WARNINGS OR CAUTIONS. BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, LOSSES. DAMAGES. OR INJURIES RESUL1100 FROMTHE USE OR HANDUNGOF THIS PRODUCT.WHETHER OR NOT BASED IN 

### CONTRACT. NEGLIGENCE. STRICT UABILrtY IN TORTOROTHERWISE SHAlLBE LIMITED. ATTHE MANUFACTURER'S OPTION. TO REPLACEMENTOF. ORTl-IE REPAYMENTOF THE PURCHASE PRICE FOR. THE OUANTITYOF PRODUCTWITH RESPECT TO WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, INDIRECTOR CONSEQUENTIAL DAMAGES RESULTING FROMTHE USE OR HANDUNGOFTHIS PRODUCT. 

### NOTICE TO BUVER Purchase 01 this product does not conler any rights undor patients govorning this product or the usn thoreot in countries outside 01 the United States. 

# e lDEF and Guthion are rogisterGd tradommks of SayerAG. Germany. 2()ropp is a roglsforod**trad~mark** of 

### NOR-AM Chemical Company. 3Harvade is a registered tradomark of Uniroyal Company.



# • "Malathion is 

### atrademark of

### American Cyanamid Company

.

RhOne-PouwtlC Ag 

### Company P.O. Box 12014, 2T.W. Alexandor Drive Research Triangle Park. North Carolina 27709 PREP Istho trademark of 

### RhOno-Pol.llenc. FOlEX 

### is a regislered trademark of Rh6ne-Poukmc

. PREptw brand Efuephon for Cotton and Tobacco (MASTER) Approved 415193. 

## •••••• • •• • 

# •• • 

## • •••••• • • • 

## •

•• ••••• 

## • • • 

## • ••••• •••• • 

## •••• 

## • 

## • • •••••• 

### ••••• 

# · "

•• 

## •

• 

# · " 

## •• 

## •

•••• 

### • • 

# · " 

## •••• 

# 89

# •

• \

. 

### \-**,~6.J** 

## It.**i!.~**



## Mr. Warren A. Davis Rhone-Poulenc Ag Company P.O. Box 12014, 2 T.W. Alexander Drive Research Triangle Park, Me 27709 Dear Mr. Davis: Subject: Revised Tank Mix Directions 

## PREP Ethephon Cotton Boll Opener EPA Registration No. 264-418 Your Submission Dated March 9, 1993 The amendment referred to above, submitted in connection registration under the Federal Insecticide, Fungicide Rodenticide Act (FIFRA) I 

### as amended is acceptable provided you: 

## with and 

### that

the

you 

## 1. Make the labeling changes listed below before you release product for shipment bearing the amended labeling: The heading "Defoliation and Insecticide Use" implies that this product is a defoliant and insecticide. Modify the 

## heading so it is clear that this section is for Tank-Mixing Prep brand Ethephon with Defoliants and Insecticides

. 2. submit one (1) copy of your final printed labeling before release the product for shipment.

A stamped copy of the labeling is enclosed for your records. Sincerely yours,

Cynthia Giles-Parker Product Manger (22) Fungicide Herbicide Branch Registration Division (H7505C) Enclosure



# 90

# (;"!JH0!y!=,:POULEIY<;:" ,**'~~.?** -- -- r=r,"'



# I AHONE-POULENC AG COMPANY



### ETH 93-UJ 

### March 9, 1993 U, S. Environmentall'rotcclion Agency 

### Office ofPesticideProgram Document Processing Desk Room 266 A, Crystal Mall No.2 1921 

## Jefferson Davis Highway Arlington, Virginia 22202 

### Attention: Cynthia**Giles~p(lrker** 

### Product !I,,1anager (22) 

### FUllgicit.'ie l-lerbidd,' 

### I3r,1J1ch Registration Division (H750,'}C)
Dear tv1rs, Pnrker:


### RE: PREP brand Ethl'phull For C\)ttll)( 

### -And Tobacco EPA Reg No. 

## 26:1A IS


### This label al1lc:ndment includes;) lIlinor (h,lngc 

### deleting thecaption "Compatibility" 

## <11td '>llbstitlltillg Ilw hetlding" 

## De[nlianl and 

## Insecticidv LSt'." Linder 

## this section lYC' hJ.\,(' added 

### till' statL'I11('llt " 

### FoJ!O\\' ;dl applicable prCc,Hltit)JlS dnd T,ltes pCI'**acri..~** 

### n.->commenddtions (In tlw producb 

### ,lpplied ill sequence or 

### tank-mixed 

### \\'ith Prep brand 

### Ethephon For Colton and 

### Tnb,lC(U Llble.
To

### complete our 5ubmi5:;inll \Vi..' 

### h.lve enclosed an application for ilmended • registration 

### and 51,lbcl$. l\Jo offers t(l 

### pny**'Wl~re** 

### filed 

### to support this request**a~n·** 

### Rhol1c-Poult','nc is till' only registrant listed 

### in the EP;\ 

### index of data submill<;l'SJh:It has**clunJh,~n:'<1ble** 

### d<ltd 

### on file 1.'.'itl1 tlll? 

### Agency. In ,H,.idition 

### tht! l1<1t\lre 

### of the ••••• prnpos(:d changesLin",s 

### nut n:''J\llI'e 

### additional 

### supporting d,ll,l SUblllission... • 

## • • • 

# · 

# .. Wedesire to 

### print Ill'\\.' 

### pmdlli.'1 labels wi

### thin 60 d'l)'S ,U1d would appn:..-iate**i.r·tll~** 

### minorch,mge could be rC'l'!el\'l'd 

### promptly. 

## ItYOll ha

### ve an)' q\l«stions plcast:

### ·cqnb(t
me prl)lnptly. 

### \Vl' 

### appn!(:izltt' )'t.!llr**<1~Sbt,1l1LC.** 

### • •• 

## •• 

## •

••••



### VVJrren i\. 

### Odvis Senior i{!!gistl\lliun**\1<1lug~:r** 

### • • 

## • ••

•• ••

"'0 [fOX**IlC\~** :,,',', ;,'**~rA';C{'1 ~';',:':L**  HfS\:JJlC';'W:PlU.FN'd< 'Ii..

. ('lUi**~,~j** ,(<-Xi ,i'lTU1'j,\'LCI.J.1 ,FtU[.UiiE>'

### {"'c"'" 'I'**."r':'\"~,,uU_}.:-f** '_' ,I"**_"'U;NX'O~'Ai. f)'~.T** ,rB;J1**,,~,:** <,,1-1-: (I'**~ ,~,**  , 'l.e,I.'[,I.'(**~c,._,·.j** < ."«**'~~'h;';IV·',** ,_ p. ,-':. 

# 91 •••••• 

### • 

## •• 

## • •


# ......

• •



# .. ••••• 

### • 

## • ••••• 

## • •••••• 

### • •



# .. •••••• 

## • • ••••

## --- 

# ._---**--~~**....**~.-**

PifNJ!HINNld hVmvcthmil (til f'tJVW'$f1b#0Nt 

## ,'.,om" """ 

# (Al&EPA 

# , Registration 

# 10pP'oo""w ""mba 0000 W

..

"'",,,,,,. DC 20400

# ~ Amendment Applicationfor Pesticide: other 

# 156511

11_ CompanyiProductNumoor

# I<~~f 

# 1 3 

# , 

# " 264-418 

# ,..t**Ccmp.tt/'\~t{Nam6')** 

# IpM'**,,~--** DNolU) 

# D fWSlIit:cd 

### PRE

. rand Ethephon Cotton Boll Opener 

## # 

## 22 

# 15. Namo andAddrof.$ 01 Applicant CcOO} 

# I

# ~b)(i), my product

# i!**51~i:~r** or

# idontica~**i~~~mpoSition** and labeling 

### Rhone-Pou1ene Ag Company 

## 2 T. W. Alexander Drive to: 

## Research Triangle Park, He 27709 

# I EPA Reg. No. 

## .--. 

# o Checkiffhis

### isa nowaddress 

# t II Explain below Rnal printed 11\0015 inresponse to Agency latlof cial!)d 

## f- ..**--~------** in fIl's.ponw to AgooC)' Iouardatnd



## . "Me Too'Application. 

# l- f# INotilicalion

- Explain below. Otlwlt

-explain below.**pagel!»~** ifnllQla:sary. lForsuction!and Section 11,)



## 1) 

## Added precautionary wording 2) Range of notes for 

## cotton in Southwest (see 

## cover letter)

Section III I 

# ... din, 

# I

U '" 

### r- Yes

### I"~ 

# . 

# ByO" 

# I 

# E
Yo. 

# f-j;'!
No 

# 1-1 No 

### No



# . No, pet

# pa:::~w~t. No"" 

# t= 

# , • CertilicBtlonmust**be** waf contalner 

## '" 

# , , 

## ••••• 

# 1'- I' S"o(') of ,,",,'

_

### ~**~"'"** i 

# ".: ; 

# o La".. 

# ,..., 

# B**~ t;;;;;;~M** **~"""~'** 

# .':" 16 

# Ma"",', ITo Pro,,"d 

# 1= DOmffl •• 1 ••••• 

## • ••••• 

# '.. : 11 wCO" 

## -;**IN'~** 

# P"'" NO: j 

# .::

# .. Warren A. Dav; s ISenior Registration Managet**~;,.~.**



## , 

# '.": j6


# . ICC:rtify that the S!Alaments I hawmade on Ihlslorm and all nttadwnonts Iheroto MO lItle. IlCCUfalcand compl&1Q, Iadmowfedgo fhatany knowingly 1111£0 orml$loadtng $UtlCmont may bepunishable by lineorImpritOtlmf)fll Of (StampG'd) both uodnrapp6cable law. 

# I'

# ttI~-I/6.. ,.-- 

# 1'_

# T".

....., i

### Senior Hnn 

# ,'- ,S. 

### Om,**War)~en** 

## A. Dav; 5 

### !March 9, 

## 1993**~?** e•., WhiOo

- EPA F

..Copy 

# ,,«ow**----~.--** .•...

# -- .•..**~----** ...

### -.--



### PAPERWORK REOOCTION ACT NOTiCE and INSTRUCTIONS 

### PAPERWDRK REDUCTION AC1' N'O'rn;Er MUc tl'lp&rtiflg oor<kn 

### feif' tlliz wl!nctltm \i1 '{flfqrtm{1,,;n

### i~ clltimoted to**~v~r*g&** 

### v.as howl" per (W0ponte,**i~lvd!~** 

### tlF¢ for reviewing losrructlb0D, tenrchlng existing**~t8 tCVfc§~,**  g0tMriitg .nnd mh\r;t1>lnifl» the data**r~,** NY:! c0«plll'tim arKi tW-1lwl.ng the cCl!w:-tiWl \Ii ihfcrmatioo. Stmd**C~a r"SI!rdir~**  tnll' btlrwn Ntlmlltfr -Of ooy dttmr i1i:Jpcct of rhh ({)!iut\tm of IntefMt1c>o, indudif',g SUl?J1Mtiooa for reci<Kino this b'Jftitn, to Chief, IhfcfllUtlm Polley Bmrw:tr, PM<023, U.S.**£lWir~a[** I'NtKt!OO Mtr:.cy, 401 M:>ttfMt, $U, v0shlrlgtG-{1, Dt ZIYo{;G; end to the Ofiic0 of lflfofw.s'ncn and H&gDlatcfy Affairs, DHlcce i)f MM8qJNf4flt i'.U¥1 Boo;Nt, lJalll:!;0gtcn, DC 20503. INSTRUCTIQN§j: rllIt ferm it to Ix: tiiLd for nil apptlcutk{'$ for f1!.W resi5tr;;,!8'l, 

## we WlU rH'!9;,nrathm, w;%r=nt,**rc;~Lt~dcn,** to**llW!i~()t;C.-'%** for Mtif;cQ,ii;)fW, hrui print!!d !awtin(;l, reregistration, etc. In arOOt to prCC411S lYl application f{!r <I fWW registration fiUmltttid «l. tht£ form, till'! foU$ling IMterj",\ ant**uc~** the >1!ppl!enti«l.l 1. CertlfieatilU'> j,ilth t/otp«:t to CIt:nl«l. of V!lta (EPA t(lM!\ ts70-Z9). (If oot ewmptoo by 40 Cfrt 152.31 (0) (1.)1; 2. COI'Ifid%ntin\ Statemmt of formula (ePA f!i'rm 115-7(4); 3. fotbUlntcr's exemption**Stat~t** tEPA fbrm 3570-27); ,(,. five 

### ccpiu of draft llltx;Una; 5. Three «;pies of any <fuu sl.lb'!littedi 6. Authorizllt!M letter where I1ppllcfiole; 

### 7. Hatrfcet where appticable. Sul::i\I\sslon of l&belir11j

- labeli1\9 should flr!;t be slbtltted in the fom of draft blbets with ett application:> ft;r 

### nw registratfco. such draft: tbbels may be in the form of tYPed labet tt-xt co 3.5 x 11 inch pap«r or Q moelicp of the: proposed label. 

### If prepared ae a 

### PrJCKUP, it should be constructed in 

### such g 

### way**~~** to facflit4te storage 

### ln on 

### 8.5 x 11 inch file. Mockup labels $isnifieantty 1maller thM! 8.5 

### x 11 ir.chvs shoutd be arnmtoo on 3.5 x 1\ ir.ch p6per for- Uubmi$SIOi1. SIbIIIin100 of Data**~** Oata st.bnitted In support of this application rnst 00 M

.. fuittoo fN**accor~c,** \lith PR !lotk;} 86-5, 

# I SPECIFIC INSTRUCTIONS: Pte:me read th

... lMtn.ICtiOi",s tlllt«l 

### bftlClJ before**e~tf;!tir1S** thf$ IIpplklitleo. First determine the t'fJ" of regl;:traticn action, listed in Block A, for l<hich 'fOIl !IIrc su!::mittirt@ this nppticatiOf'1o for IIppticatlorui sobmittl!d Iii**~OlIDe¢thm** with NIW Regh:trlldoo actions, $¢<;tirum I, ltI, and IV i'Alst 00 cO!fiJllltoo by the applicant. for applicatiQO$ submitted in**c~tion** with**~** regfstr-atlon actions, re&ubrnis51on#, notlflcati0n3. rereglstrlltiens, etc., Sectiorw I, fl, tmel l'llWSt be cOlVf)teted 171 the Itf'Plicant. aleck A**~** Check the 3pprcpriate action for- whlch you ure $ubmittirt@ this form. 

### SECTION I**~** This sectiru"lll'lJ$t be cOII'plllted, as applic3ble( for at[ rogfstratl!m actions. 1.**~/t'rodJet:** ftu:lber**~** InU!rt Yo(lr**~** Nlo!tix!r, if one has been anignOO by EPA. Thit**~r** !My !lave been au!gned to YOO fiG a bUle rQiiiarrmt, Ii dlstriwtor, ¢r as an f1Hoollsl'm¢nt. If Yt4Jr prOOJct It**r~!$ter-~. int~rt**  the Product Nwbor. 2. EPA Pr-lXb!t Kll!wger**~** If kl1OWfl, fill in the 1'1_ nl'!d PM I'lU'Iber of the EPA Pr«toct**~g('r.** 3. Prqxmed CIM-5fficntll.lO**~** Specify the prcpo1loo e\v$siflcatioo of thiS /UQOOet:. 4. Pn:O.JCt**~ ~**  Enter the coo:pletc prlXkJct rw..''')lH)f this poHtlcide till it wtt! apptNlr on the hbet. The n/!IWI: must be speclfic to this product ooly. Duplic!ltlon of tIfIItoC$ [$ not permitted**~** products ¢f the !i:1ll\!Ie company. 

## vo Mt inelude any brand name or**c~ny** line Ocsignations. , ' 5. H_ and Addf'esa 6f AfptiCMt**~** The It1lt<Ie of thff tim or perllQl"l and &OWe$§ sh!l\R'j II'1)'Wr awlieation is th4- person or firm to offiQrn the fcgls.tratloo wilt ba issued. If ycu are m:tiJ'!!l in bcilalt of another pt'lrty. you lW$t !'iubm\t 

### amwrfzlitlon frW! that party to act for thern In registration rMtters. An applicant not 

### residing 11'1 tho:! Urdted States Jl'Ll$t: hove 

### an 

# I

authorized &gent residing ;1'1 the United States to net 

### tor them 

### in att registratloo !Mtters. The n&14 and complete ®ai!i addreilS of weh an agent !llJ$t**iKC~** this IippUcaticn. 6. Expedited Rev;mt

- fffAA sactioo::; (c) 3 (5) provlde$ fer qXpl!dited r1T.jiew of apptieaticm for regl$tratioo, or**~t** to «)(1$t1ng Ie-ghtratioos, that arc llimilar or Id«!tieal' to- ether pesticide prcWcu that lire currently regi&tllred with the EPA•
.... rdctr fOr your application to- be ellglblo for {,'xpt!dlted review, you l!W;t provide us With tho EPA Registrnticn ••oHi.$(w and 

### PI-<Xb::t r;MlC of the product you b©licve Is ",{",Hill' to (lr 'fklnthnt to your fWo:.:lw;L Th>: p.rn4lct lIMIt, be 

### : -Siml lar u: ipcl\'1,feal if> b¢th forwulat Ion t>rd lebeted wee\!• 

## •• •• ••••••**~ION** I·I

- Thh s(!ctlan !amt be crwopletoo fQr- att apptiCtltioos s!..b1litted to woffid fill! reOl$tratien enly of 11**~wsty** rl!jihtpf! proriuct (Alnu'd1.cnt), for a restb\1iniw 

### in resp¢I'I£c to an Agency lettltr, fCI1" ootlf/cntiens to the**~ir::Y~** for tt.at s*,s!idoo of fin()l printed labet/ng, for rercghtr!ltioo 

## ru;d for nny other- actioo that p$rtalns te a noo;if!c**~:rHI!itltrn~.** This .section is!!2! in

### £! USul 

### tor II 1l'¢0l applfc.:ltH)(,I f",r rtrghtratlen. 1. $Wjllet 

## oJ-**~h:SiM** • Check the aWl leable blod; nod provide: tho Aget)(y letter dt.te if**~cpriatc.** Provide a brief :··Wl1Nltioo,pf the p!Jrpose(s) fqr the**'~i&'J;ioo,** such a<l**~thtl:** addition of a sitJ:, pest 0; crop (specify)"; "amend the**"ConHdooti8~** StatOOlOOt of fornut:a by

...**~; "rer~h:tratioo**  S>.blll1lSioo"; llUlerat label rwisllXl of**Ul~e** dtrectiCM." Attach ••••**~rat.t·paQl;!:if** OOditlonnl space Is need«}. 

## •• ••••



## •• •• SECTION: Jilt. (Packaging and container Information)**~** This Section f1mt

### ~ c-wplo:!too f{)r all eppUcati«MtlutL'tted in cOI'lrfecticn with MOl rttglstrbtion or apptlc.nble**~u.** 1. Type'of PM:btuins**~** Check the appropriate b[rn.:k If your product wilt be packaged 

### in the indicMoo pac)({I[Jir,g types. lndicate the $i10 of th!;! individual packets and**~r** p¢r retait container. 2. Type of Retail Container**~** Indicate type of c'Mtalner in whjch prOO;ct vII! be l!'oIIrket<td. 3:. location o-f Met tcntMt#-**~** Specify the net contents of

...tl retail c.:;ntainers for your prodoct_ 4.**Si~e(s)** of Retail Container**~** Sp<lcify the ml; Contffit;; of alt retAil coota;/Wrs for yovr product. 5.**l~tioo** of Uue tlireetlorn;**~** Indicate the l.x;atloo of the ooe dlrect;;:,r,tl for yt'iUI" pro4.lct. , 6. KwTIer in lAtich labei 1$ -affiltoo to pn:dtct**~** tndicate the IMthoo prod<J<;t label IS**!ltt;M;heQ'~t.f)** retail cOOttliMr",**~ ",~,%,,"""<**  "" '-,," ",,;;,;;;, 

### SECTIQH IV 

### (Contact Point)

- lhlt slktico m.Jtt be coq:.tet«1 for all applications for RlI9istratloo ect!cm, i .t., new products regllltrJ:ltion, l-5.**Self~t.)(pl/101ltory.**

6. EPA Use Oniy. rl:!;;t.bnissioo, "me-tlXi," reregistration, etc. 

# 93

# ,IA)'&EPA "oC 20460 

## oour 

## Pesticide:

n 

### I 

## Registration Amendment 

## other 

# 156511

r lr

# ~~

# ______**~**

# __**~2~6{~f.~4~18~**

# ________**-4:,:'C"":.:P~~~:: ~**  1,1.

# co;~~~~:~am;~hePh0n CottO!} I"

.

# .,~ 

# o NOM 

## noj 

## 1 Op£mer if 

## 22 (fncJudo ZIP Code) 

### 6. Expedlted.inaccordance with

. 3(c)(3) (b)(i), my product is similaror idenlical in composllion and labeling 10: 

## oy DriVe EPAAeg, No""
______________ _ 

# o Chodt;if/hisis IJ

### newaddrru:s ProQue! Noma

Final prinWd 1n00t$; in rosponso w • Amcr.dmcnlo Explain botow

# ~ R&submissioo In response 10Agency Ic!tcrdalad'
____ _ 

## IAgency Iottllrda1Od",
____________ _ 

## I-- Nolilicalioo + Explain below_ 

## I-- Explanation: Usa addillonaJ P.(s) if

### nocessary. (Forsectioo Iand "Me Too' App!lcalloo. 

## l-

# IOt!wr

- \)Xplaln lxllow



### fI' II

.. 

### IUnn OIn'

# ~----------------~ 

# ,8**Yes~** ,: r YOIl 

## I- IYOS No' Nn No

# hf;~~~~:_-N~.~,~~~_t~";~~M~,~.~~-_:No~,~~P.:1 **• Certlflctdlonmustbe**  

# Ii wgt conlainM PackageWgl container 

### I 

# .' : 

# : 

# ••••• Or 15, 

# .,t."", I**El~;>;;;~,** 

# ".P,."",, rI

# D om«L----

_____**r~·~·iL·)** 

# ••••• 

# .. 

# ..**IN.~** 

# '. Warren

I(';(Mlily mathstatements I have madeon mis form and aIIunachmenlll theretoare !rue, aocorato and compklta, !acknowlodg&thaiany knowingly Ialro or misleading stalemool may beponfWabkt by line or impri&Ol1mOOI or both underappUcabio law, 

# f3 TnIo 

# I"" iOY' i'vihlY0! i(v, ,.

Whil«

- EPA (SllImpcd)

### PAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS 

### PAPERWORK REDUCTIQN ACT NOTICE: Public reportins burden for this collectioo of informatitm is estirMted to avenge 0.8S hour per r«lpoml;}, iocluding time for revIewing il'l4tructiO/l$,**~ellrchll'l!1** exiMfOQ data s<wrces,**gat~rinv** and maintaining the dahl**~,** lind cCi\?letir.g .md reviewing the- collection of fnfc.rmation. StlmI cocrnents regllrding the burden estimate ttl' any other flSpect of thi$. collection of irtformti"". including SUijscstiOfW; fer reducing this burdett, to Chief, Information**Ptlti~** llrOOGh, rth!'Z3, u.s. EfWlronnental Protection Ageney, 401 K Street,**S~,** WlIshinatcn. DC 20460; and to the Office of Inform:ltlon and Regulatory Affairs, Office of MaM'ilement lind eudgot, IJllshington, OC 2050:5. 

### INSTRUCTIONS: 1his f6Nn is to 

### M U5ed fer 

### all applicatiOM for 

### new regIstration, end 

### use rereaistratioo,**llIOO~t,** rllSf.blIission, to appllcatioru for tlOtificatims, final printed labeling, reregistration, etc. 1n order to process at'; application fi)l' \'I IW# registratiOl'l st..b11lttoo 

### on this iorm, the followIng !llaterial nmt accoorpany the appticatlon: 1. Cf!rtlficntion with RHfXX:t to Citation of Data (EPA form S$70-29). Of Mt f!xOO()ted by 40 erR 152.81 (fl.) (4)1;**2~** ConfidentIal Statement of formula 

### (EPA Fona 

### 8570·4>; 3. formulator's fxlI'!!'pUon StIlItcmmt IEPA fom S570-27);

,. five copies of df"ilft labeling; 5. Three copi" of lilly data sublilttcd; 6. AuthoriZation letter where applicllble; 7. Matrices wheri!' awtfc>1Ibte. SUballuion of labeling

-**l~tlng** should flrst I» slJbnittod In the fom of draft labels**~ith** all a;:plicatfOlW for new registration. Such draft labels Ny be In the form of typed labltl tWlt on 

### 8.5 x 11 inch paper or a mock.up of the prOJXlS«.l !3bel. 1f prepared as 0 mockup, it llhe<.!ld be cctl$tructed in su.:;h a vlIY liS to hcilitllte storlllO'l' in l1l'i 8.5 x 11 inch filf!. MoefWp labels aillfliflcantly smallor thm 8.5 x 11 irn::hell' should be! mounted on 8.5 x 11 loch paper fot' subnfs!:lOl'l, SUaihion of n.ta**~** Oua sutmlttod in Sl.fPOrt tti this IIWlicatlon litiS! be subnltted in accordance wIth pft lIotiee 86·5, 

### SPECIFIC INSTRUCTIONS: PlellSe reOO the lru:tructlom listod txllow before completing thIs applicatIon. First**~termine** the type of registration action, listed in Block A, for whlch you are submItting this awUcatloo. for applications sub'aittod in c6n!'le(;tioo vith 11M! Registration actioru, s(U;tions I, Ill, and 1V Il'Uiit be**e~letod** by the uppticant. For awlieatiOl\\l ,\bI!itted in cOl'll'\(tCtion with**~** registrtltlon actions, rfl'SUbllluions, notifieations, reregistrations, etc., SectiON: I, II, Md IV trtnt be coupleted by the 8pf)ticant. 8locl:: A

- Check the appropritlte action for which 

### you aro stbllittins this form. 

### SEC'rIOlf I

- ThIs section !l'mt be cwplettd. as OWl**icabl~,** for alt registration actions. 

# I

1. CaIpIny/procb;t: MlIIbcr

- Insert yow- COIIlpcny MUJt,er, if one has btwro u,igMd by EPA. This**~r** Ny have boon auigned to you IS 

### It basIc r%!lstrent. a distributor, or a;s an estnhffthment. tf Y«Ir product is**r~i$tltred,** insert the Prtli:b:t 

# _ .. 2. EPA Prcxb::t Konoger

- If known, flII in tilt> NIIlII and PM rtI.l'I'b<Ir of the EPA Product Kmager. 3. Proposed Clas.sification

- Spedfy the prOPOIlOO classiticatlon of this product. 1,. PI"tlICb:t II-.:

- Enter tha couplete product name of this pesticide- 48 it witl eppoar on the label. The rnIfi'Ieo must be spoeffic to this product only. Ouplicatlon of f\aIIlH is not perl'llittoo 1Ii!IIOO9 products of the s_ 

### cwpany. 00 not include any brand IlaIIIe or**c~** IiM designations. 5. M_ QfltfJd.tres,s of Applfc&nt

- lhe I'Wf4 of the ffl1!l or par$¢t13l\d a6Jrcss slwwn in your application is the pl:!rsQO or firm to WlOIII the registration wItt be issued. If you are acting In behalf of another party, yo\IlWst submit authOrization frOQ that party to &et for them in registration JIIIItters. An app1 icant not rlf$iding in the United States IiUSt have on::& 6Uthorized agent rolding in the unIted States to act for them in aU re;istration lI'.atters. lhe NiII\(t end cooplete _ltl addrKS of SlJCh en ageot !lUSt aecOll1)6ny this appl jc&tlon. ' 6. Expedited Revill!fll

- FllRA Sl](;tion 3 (c) 3 (It) providee for ellP¢ditod**r~few** rn appticatiOl'lS for rogistration, or to existing registrtltions, that are eltllllllr or identical ttl other pesticide products thtlt are currClltly registered With the EPA••tn.order for your application to 00 eligible for expedIted review, you ffiU$t provld€: 1)$ With the EPA Registration
••••**~r** ar,q"produc:t I'IiIII\a of the product you bellieVl! Is similar to or i&.nticlill to}'<>Ur product. The product m.Bt be

• •• s;"'flllr.,r Idfmtical in both forNlatien lind lebeled Wies.


# ... 

# ... •••• 

# :)itt:rXON ,I

- lhis uctiOl'lllLl$t be

### c~lnte<:l for aU applicatIons sul:l!littod to GIMf'Id the registration only oi a

currently ret,istc.red prodJet**(~t),** for a rc§!.Jl:Eiis5ion in response to an Agency li'!tti'!r, for notHiclJtlons to the 

## •**~9IMvk** for'iel stbmission of firml printed lobetlng. for**rer~j$trlltion** 

### .nd for any other action thiilt p!!"rtains to I)**~pru;.;:fi5**



### m'ftgiltoccd Woduct. This Gection is D21!9.12i used for a oow application for regi;tration.**~** fkbject 

### pf·9Priasion

- Cheek the npplicablo block MId provide the Agency letter date if appropriate. Provide- 

### a brief :.·.tlltplana:tion of the pal"pOse(s) for the submIssion, such as "the,ao:kUtion lit a lite, pest or crop {specify)"; "M1Crd the

••**·conffdmti~l** Sttltlll!!reflt of forll'JJla by•••"; "reregistration WbIIlssfon": g_ral label revis;ion of use diractioru;," A'ttllch •••••.separl}t\·H if &dditlonal space**is~.** 

### •• 

## ••••

•• 

## •• SBCTIOI ,,!IJ: (Packaging and COntainer Information)

- This Section must be cooplet«l for all appt!clJtiotV

.. itted in conneetion wIth nIW tegistratiom or 8pf)ticabte**~ts.** 1. Type: of**Packagi~** - Check the tlppropriate block. if your product will be pad:allccl in the irdicatro packagIng tytWli. Indicate the sit. of the fl)jiv!dual packets and I'i\.6b(!r per ratail C«Iuioer. 2. Type of Retail container

- Indicate typt! of conulner in whIch product wfl 1 be IUrketed. 3. Loeetion flf lIet contents

- Specify the net contonts of all retail eootalners for 

### your product.

,. Sines) of Retail Container

- specHy thlt net contents of all retail contaioors for your produet. 5. Location of Use Diroctiom:

- Indicate the location of the USIt dir«:ttons for your product. 6

....... 1' in ...ttich label,. afffxed to procb:t

- 1ndiente the I!lethod product l$bel is attached to retail contairwr. 

### SECTION IV (Contact point)

- Thlli Section ffJJst be ctq)lltted for fill appliCiltiom for Regbtratlon actionli, i.It.,**~** products registration, rosubnission, "me·too." reregistration, etc. 1-5. self-olq)lanatory.

6. EPA 

## u.. Only. 

# 95

### IQ: PILli ROOl(

_________________ _ 

### lXlCUKElIT C!IITZII

______________ _ 

## PROOQCT MANAaElI.**---_~**

## ____**~~?6~~~**

# ____ __ PAll (ROOM 263)



### TYPE Of REqrSI?JJ:9N 

## PAST

- TRACE ACTION (with

# ~thout**da~** This action has b••n determined to b. a tast-trac:k IC'eion 

# by FEPS and**~** 

# ba antared in the 

# PRATS uI1nq on. of the follow·inq cOdes: 

## 160
- Application for "me-eo" reqistration l70

- 

## Application for reqi.tration

- old chemical

- "Ma

## tool' with 

## additional u.••• 

## 300
- Amendment
- laQal revision
- administrative (no**d:at~** 

## t'equired). 

## 305
- Amendment
- label revision
- data required dee. nQt 

## ne.d 

# HED/ErED review. 310 - AlI1end.ment - added "me-too" Use - no HED/EfED revie..., 

## n••ded. 

## 345

- Formula chanq.

- no 

## HED/EFED review 

## required. REGOtAll REGISTRATION 

## (with data/without data) 

# 24e II7llf 

# He**~lI%lI'1'** 

## RE8UDXI.IION (••• 

## poa•• tQ 

## AQ8DCY**lt~) rI~·PaIlITBO**  

## LABILa QTIlIa 

### 1I%881\GI'

______________________ _



# 96

# 97

# a UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, 

## D.C. 20460



## MARGARET CHERNY RHONE-POULENC AG COMPANY P.O. BOX 12014 03/26/93



## RESEARCH TRIANGLE PARK NC 27709 OHiC£OF PREVENTION. PEStICIDES AND TOXIC suaSTAtiCES



## Product Name: PREP BRAND ETHEPHON COTTON BOLL OPENER Company Name, RHONE-POULENC AG COMPANY Application No.: 156511 EPA Reg. No.: 264-418 

## EPA Receipt Date, 03/25/93 

## Subject: Front End Screen for an Amendment

Dear Sir or Madam: Your application for registration has been received by 

## the Office of Pesticide Programs and has passed a preliminary screen for completeness. It will be placed in line for review to 

## determine its acceptability. The application will be processed in chronological order of receipt. Although the 1988 FIFRA amendments mandate EPA to review 

## applications for expedited registration or amendments within 90 days, this turnaround time will not be met immediately due to the backlog of applications received before December 24, 1988. However, EPA is increasing human and automated resources and making necessary procedural changes in order to eliminate the backlog and to meet the 90*day response time as soon as possible. If you have any questions, you may contact C. Giles-Parker, Product Manager 22, at (703)*305*5540.

Sincerely,

# cd.Af)JJ...~ Team Leader Front End Processing Staff Registration Support Branch Registration Division (H7504C)



# 98

# • •



# • • UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON. D.C. 20460



# APR 5 1993**OF~aQF P~""'EN1\ON.**  "ESTlClOU MlO rox'c SUBSl"t.cCS



## I, cynthia L.**Giles~Parker,** 

## Product Manager, Fungicide-Herbicide 

## Branch, Registration Division, Office of Pesticide Programs, Office of Pesticides and Toxic Substances, u.s. Environmental Protection Agency, do hereby certify that the pesticide product listed below 

## is currently registered with this Agency under the Federal Insecticide, Fungicide, and Rodenticide Act, as amended, that the label attached is a true, correct, and compared copy of the 

## correspondence of record, and that the product may be sold and 

## marketed in the united States of America for the uses indicated on the label. 

## The product registration listed below has been issued to: RHONE-POULENC AG 

## COMPANY**P~O.** 

## Box 12014, '2 T.W. Alexander**~Drive** 

## Research Triangle Park, North Carolina 27709



## EPA RegistratiQD Name Qf Product
264-418

I



# ...

" 

## , 

# , \ \ 

## PREpN brand Ethephon for cotton and Tobacco

IN WITNESS WHEREOF I have hereunto set my 

## hand and affixed the seal of the**U.S~ ENVIRONME~tPROTECTION**  

## AGENCY 

## this**~** 

## day of 

## II..J**A~**

## D. 1993

# ···~.d-7~· , cynthia L. 

## Giles-Parker Product Manager #22 

## Fungicide-Herbicide Branch Registration Division (H7505C)

## ~-­ 

# _ ..

# _-- ,,"":'a

__ 

# 99- - - 

## -- --- -

- .**-~-------**



### r-- 

# (.- 

# - i**'1I~** 

# RHOfIJE-POULEflJC 

# •"---.J



# • •



# • • RH6NE-POULENC AG COMPANY

February 19, 1993 Mr. 

### Robert Taylor Office 

### 01 Pesticide Programs (H7505C) 

### Document Processing 

### Desk (CERl) 

### U.S. Environmental Protection Agency Room 266A, Crystal Mall 2 1921 Jefferson DavIs Highway ArlIngton, Virginia 22202

Dear Mr. Taylor: Re: PREpTM brand Elhephon for Cotton and Tobacco, EPA Reg. No.:**264~418**


### Please provide us with five (5) certificates of reg/slr,alion forthe product referenced above. Please Include the following Information on each certificate: 

### (1) Registrant: Rhone·Poulenc Ag 

### Company P.O. Box 12014,2T. W. Alexander Drive Research Triangle Park. North Carolina 

### 2n09 (2) Name ofthe Product: PREpTM brand Ethephon for Cotton and

### Tobacco, EPA Reg. No.: 264-418 (3) The phrasewilhln the body of 

### lhe paragraph: "

...that the product may be 

### sold aod marketed in the United Slales ofAmerica forthe uses indicated on the 

### label."

Since one ofthese certilicates

### will be 

### needed in the country of request In 30 days, /would appreciate yourass/stance in expediting 

## my request. Please contact me at (919) 549-2112 should you have any questions. Sincerely,

Judnh

## L. Moore Administrative Specialist 

### • •••



## • •• 

## • •• • • 

## • • 

## •• • • • •• 

## ••• 

## • • •


## • •• 

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# 100

# PREP TM

# BRAND ETHEPHON FOR COTTON AND TOBACCO
For Commercial Use Or Agricultural Use Only. Not For Residential Use ACTIVE INGREDIENT: Ethephon (2-Chloroelhyl) phosphonic acid' "

....................,....................."

..........55.4%



### ...........................................................................................44.6% 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO
PRECAUCiON AL USUARIO: Sf usted no 100 ingles.. no usa 9ste producto hasta quo la informacion on la oliquela Ie hays side O)(Plicado 

### H

# ~~u~,~.~~~~~~~~~f,t~~~~~~~~~~u~,~.~.~~~~~~~~ iii 

# j

. Patents 38, ,188 and

# ',:,;,,0:8,9:, granted 

### to use this product other than the orfor any nol contemplated by this Uability for patent infringemont 

### may result from use or sale 01 this product outside the United 

# STATEMENT OF PRACTICAL TREATMENT IF IN EYES: Hold eyelids open and Hush wilh a gonllo slrllam 01 waler for al leasl 15 minutes. Gol medical anonlion, preferably an ophthalmologist tF ON SKfN; Immediately wash skin wllh plenty 

### 01 soap and water. Remove contaminaled clothing and shoos. Wash clothing separately boforo reuse. fF 

### SWALLOWED: Do not induce vomiiing. Promptly drink a large quantity 

### 01 milk, egg whiles, gelatin solution or if lhose are not avallable, drink large quanHlies of wator. Avoid alcohol. Cal! a physician immedialely. IF 

### INHALED: Remove victim to frash air. II not breathing, give artificial respiralion. Administer oxygen it necossary, Got medical altention. 

# PRECAUTIONARY STATEMENTS

AZARDS TO HUMANS AND DOMESTIC ANIMALS 

# / 

# • I ANGER
,00ROSfVE. Causes eye and sk"ln damago. May be latal ifabsorboclthrough skiii Harmful11 swallowed or inhaled, Avoid breathing sPlay mist. Do not get In eyes, on skln oron clothing. Wonr fullleOQlh trousers, long sloeved shirt, protoctivG gloves, and 9099\05 or face shiold when handling. Change 10 clean workdothesdaily. Wash thoroughly with soap and water after handling**~4d.** bGfOfe eating, orsmoking. Removo and wash contaminaled clothing before rouse. Keep away from domestic animals. • •••••• NOTE TO PHYSfCfAN ••• : :.: Thore is no spacific anlidolo. Alltreatmont should be based on observad signs and symptoms 

### 01 distress in tho**pat:ent·bvere~ttt** 10 materials other than this product may have occurred. • •• Victims of severe overexposure, by inhalation, should bo kept undQr medical observation for up to 72 hours for delOYctq.gl\set ot· .:••• pulmonary edema, In a victim of over-exposure by ingestion, caretul gastric lavage is required due to the possibility.of11q.mach bt ••• esophageal perloration_ This material is an acid, but use of alkaline substances to neutraliZe It is contraindicatoo.. ••• : • 

### • 

## ENVIRONMENTAL HAZARDS • •• Do not apply directly to water, to areas whore surlacewater is present orto intertidal areas below Ihe moan high**wa~tJwA.** contaminate walerwhen disposing of oquipment wllshwaters. • • 

### • 

## •• Do not contaminate water usedfor irrigation ordomestic purPOSl1s. • ••• 

## USE PRECAUTIONS Do notapply PREprn brand Ethephon through any type 01 irrigalion syslem. 

### •••••• 

## • •



# .,

Avoid spray driftto noarby crops as this prnduct will cause modifications in plant groW1h< Plant infury or reduced yields

### will resull. Do not plant another crop within 30 days aftertroalmenL Mix only the amounl 01 spray you expect to usc each day. Do nOl allow mixed solution to sland overnight 

# 101

# DIRECTIONS FOR USE It Is a vIolation 01 Fodorat Law to UlH thIs product In a manner InconsIstent with rl8 labetlng. Read enllre labol bolor. using thIs product. 

## REENTRY STATEMENT Mixers, loaders and applicators must wear a tull /aCit shield, long trousers, long skJ,ovoo shirt, gloves and boots to avoid as much skin 

### and eye contact as pouible. Do not onlor treated lioldswithin 24 hours after application unless protective clothing is worn,



### nO! contaminato water, lood.

### or 1000 

### by slorago or disposal. 

# I" ''','''Iain.,'.broken orcontents have spined, 

### lolrow an precautions indicated above andclean up immodralely. 

### Belore deaning up, po< 

### on,"" length trousers, long sleovGd shirt, prolOClivo gloves. and goggles or lace shIeld. Soak up spill with absorbont modia such sand, earth orothersuitable material and dispose otwnslo at an approved wasle disposal lacWty. DiSPOSAL**l~,,,,ticid**

### •• 'as'''.areacutely hazardous. Improper disposal of oxcess pesticido, spray mixture, or rinsato

### is a violation of Federal law. wastes cannot be disposnd 01 by Use aCQ;)rding to label instructions, contact your Stato Pesticide or Environmental Conlrol orthe Hazardous Waste roprosontativG at the nearest EPA Regional

### OWCG lor guidance.**1?~l'AINIER** 

### r



## GENERAL INFORMATION COTTON Ii 

### aod**d.,>o~."I.i:** a sanitary

A**fo~ar** spray 01**PREP1~** brand Ethephon will accelerate opening 01 malur& unopened oollon 

### bons and enhanco dglonatlon which can result in earlier harvest with an increasod recoverabl(!l yield. PREPi>:' brand Ethephon treatment on cotlon allows incroased ofiiciency lrom a once-over harvest. TOBACCO (FLUE-CURED): A toliar spray 01**PREPJ~** brand Ethephon promoles 

### early. uniform "yellowing" 01 mature tobacco. PREp1Id reduces

### curing timo, allowing more efficient use 01 curing barn !!ipace, and inctoas&d control over harvest schedules. 

### SPRAY PREPARATION Add 112 to 

### 3/401 Ihe required 

### amount 01 water to the spray lank Start agita!ion. Add the roquired amount 01 PREpn.o brand Ethephon, and tho rgmaining amount of water. Prepare only 

### as much spray solution 

### as can be used on the 

### day 01 mixing. 

### Do no! allow spray solution to stand overnight. Do no! spill tho coocentratod prOOuc! on $pray equipment, or any airplano par1s, 

# I y SPItlSSHOULD BE RINSED IMMEDIATELY

### WITH PlENlY

### OF WATER $001 

### a nurso lank is highly recommended

. . possiblo spins 01 concentrated formulation on spray equipmont or any airplane arts.



### Good agitation in tho spray lank is ossontial and 11 tank mixtufl)should not be.allowed to stand without agitation minutes. Read and observe aU approprialo label use dIrections and precautions lor the delolianls and inSOdicides.USO$f!: • 

### NOTE: Under certain conditions, tank mixtures 01 PREpr.1 brand Ethephon with desiccants conlaining sodium chkVate Could • .,.••• result in Iho lormation 01 hypochlorous acids which on heating will emil toxic chloride IUmes. • •••• EQUIPMENT CLEANING : .:::- ••: ••: Because 01 tho acidic naturO' 01 this product. prolonged exposure to spray deposil will damage acrylic plastics. setta!1) paint's: and motals. • ••••: Rin!!io thoroughly wilh a delergon! and water aU exposed acrylIC plastlc-type malerials (o,g., aircraft windshields). and painted surlacGs wIthIn 

### an hour attor exposure to spray doposils. At the end of each day. rinse thoroughly wilh a detcrgont and water an the metal par1s 01 the aircral! and the associated spray equipment oxpo!!iod to Ihe spray deposits.



# 102

### i 

# COrtON

USE

PREp'nI 

### 8011 

### Opener·

PREp1l( 

### + 

## FOLEX*

IIx Tank



### Dropp2 Defoliant Tank 

### Mix

Pre·CondItIoner 

### for Defoliation 

## EXPECTED CONDITIONS



### Hot and dry BO$For higher Ory and75

### to iWF
Cool 

### but above 65°F m Rook ooHon High soil moisturo m 

### High lortillty lovel m Rank ooHon High soil moistllfo High fertility level Rank cotton

Hot, dry, above BO'F Cool, aboVe 65°F 0< Rank colton 

### 1113


### 2 2213



### 113

113



### 213 I 1!3 

### PREpni RATE rRE 

## <J!, lBS A.I. Acr•• 1.0
1.5 

### 2.0

0.25

0.25

0,5 1.0 

### 6
4 

### 3



### 24

24

12 6 SPRAY VOLUME (GalslA)



### Air"

2-5



### 15·50 

### 5

- 

### to

tS- 

### 50 2-5



### ·Pretreatment With Defoliants PrIor to PREp'fM Boll Opening Treatment APPLICATION 

### TIMING

Apply 

### whon tho number of 

### maturo unopened bolls is sulficionl to produce the desir&d crop. SIlO 

### bolow for lost of boll maturity. Treatment uniformly opens bolls 7 to 14 days earUer,

Apply 4 to 7 

### days prior to PREplM boll opening 

### application. To bo 

### used as a sequontlaltrealmen1 wilh, not

## i~~~I~~~9_.01 PREPni boll**~ppl~** 

### 4 10 '-**d~y,** 

### p,jmlo 

# " '..

# -:~~

Hthe catton Is overly rank or laying down in tho middies and good spray coverage of the bolls with PREpTM is difficult, a pretroatment with dofoliamswill

### be usefulto improve boll covorago with PREplM, Use dosage ratos 01 PREpm brand Ethophon recommended lor 

### boD opening. Read and ohsorve all appropriate label usedirections and precautions lor tho defoliant used. / 

# l In Galifornla and Arizona use a volume of no loss than 5 galions per acretor aerial applications. 

# V all Maturity

. A boll is matumwhen it istoo hard to bo dentedwhen squeezed betweenthumb and fingers, too hard to be slicedwith a sharp knife, and when the seodcoat becomes light brown in color. .:• 

# • Use Limitations • • Do not exceed a maximum of 2.0 lb. 3l/Atorcombinod uses ot PREpl"Iol por aero per year. 

## • •• •

## ••• BoD Opening: 

### Do nottank mix PREpr>< brand Ethephon with a desiccant iftho cotton is to be spindle harvested. • 

# .. . •

## ••••• 

## • 

# •• • • •••••• • •

•• Pre-Condition tor Detoliation: Do not tank mix PREP').! with desiccants unless planl dOSlccation is required,**~ ~J1So**  a dltrtfiM" bofore there is sufficient matu!& unopenod bolls to producetho deshed yickl (soo GenerallnfOlmation sllClion on**hq~**

## 10 tost'fMMIl maturity. •• • • • 

# ... WHEN TO HARYEST COTTON • •••••• • 

## •

•• 00 not harvGst ootton soontlrthan 7 days aftera trcalment with PREP'm brand Ethephon. : •••• • ••••• Observe tho treated crop and harvest whon optimum boll opening has boen reached. Too early harvest might

### roduc~ Me·tull

## advui.· 01 tho troatment andtoo late a harvost may result in mduced quality and IoS$ of lint which will droptrom tho plant. ••• : 

### ••••



# 103PREplM 

### Crop Situation Plnts/Acro


### 1 113

Over-The-Top Application 

### 1113-2213

USE LfMfTATtONS 

### 50-60



### 4O-SO 

# TOBAeeO (Flue-Cured Only)

Specllic Directions
Uso drop nozzles. Chooso TG or DC spray lips designed to apply 50 gpa at 

### 35-40 psi and at 

### tractor speod of 

### 2-3 mph. 

### 2 nozzles perrow; one 00 each side offhe

# rowdropped~:::,~:t~~;:2:

# I

the spray to the loaves to bo ripened and harvested. is essential. With Ii diroctlKi spray, 

### be sure to harvost II 

### 1 Treat only whon laavss remaining on the stalk aro 

### remaining loavas are maturo, lost $pray soveral 10.1'''''0 

### described undorthe section ·ProporlimeofTreatment." In a normally mature crop whon exporienco indicates that

### m:~~'~~:**~:'~~~**

# I**indu~ment** is required, Use Iho higher rate when the crop i a tendoncy 10 

### be more rank or when lemporalurl;Js are lower**:.~~~~:~**

# I Always lost sprayto delarmine 

### if tho tobacco is mature enough to lotroatmonl with PREPn{brand Elhephon. Apply over-the-top PAEprn brand Elhophon spray as a line mist using nozzles (one nonln tips over tho cenler ofthe plant, and ono on each so all leaves are covered , similar to the



### Do not apply PREp!'>! brand Ethephon to immature toaves as this can result in unsatisfactory coloring, waight loss and reduced leaf qual'llY. Do not allow the crop to ovar ripen in the lield alter using PREP(Y brand Ethephon, sinea this may cause somo lQduction in yield and quaJJty, 

### Do not treat before anticipated major storm which could prevent harvest and resutt in crop 

### loss. 00 not apply PREJ>1M brand Ethephon 

### if rain is t'Ixpocted within4 hours. APPLfCATION TIMING Successful results with PREP'I"! calJ lor treatment when leaves are mature, not overly rank green when sprayed. To al15ily determine the proper trsatment timing and the number01 leaves per 1$tall< roady lor harvest, tast spray sevsral planta in more than ono location in 

### eachfield 

### and observe the response. Malur& leaves will begin to yellow in 

### 24to 

### 72 hours. Test leaves that fail to yellow in 

### 72 hours are not ma.ture and are not ready for PREprn brand Ethephon treatment. Wait a IGW days to pormit 1urther natural maturing, then make

### her test spray or "maturity· check.

hen you have confirmed the number 01 teaVQs per plant that will color. you can detormino the numbGr 01 acres to troat in order to till eOOm. Prepare yourtast spray 

### by mixing one toaspoon ot PREP1'" in t quart ot wator, Spray each tost plant with aboul t o. ot this mixture, covoring aU loavoswilh a rlflo mist. PREf>1"" bmnd Ethephon wiU not color immature sprayed teavos. .:. 

## •••••• WHEN TO HARVEST • • ••• AI) mature. sprayed I&avos wiU !>&gin to colOr wilhin 24to 72 hours alter PREpw brand Ethephon application. Tho**y\ll~~** proc:ss IS • weather dependent: cool weather will dolay, whHo hot, sunny weather can speod up the process. Harvest treat&d toba,cowhen';i.v,;; have reached the desired color lntonsity. •••
... 

### ••• 

### ••••• Do not allowtobacco 10 bocome ovor ripe bolore starling harvest. loaf drop can occurwhon tobacco isovor ripe 1tnd\;iton

### th.~.· II a numberot tho bottom loaves have yellowed at the time oftrsatment, they should be harvesled priorto spraying,f..it$'tREpl'" brand Ethephon. ••• •••••• 

# . ., With an over-thlHopapplication, harvesting can commence 24 hours aitor PREP'I'" brand Ethephon application de!lOnV\r90n weellf/l'r**co~itions** orto avoid ovor

### ripe tobacco, Tobacco harvosted 

### 24 hours altertroatment will require more !fme in the**ool~!n.srphasqef!tt!&:** cUring process. • • • ••• CURING PREP"" TREATED TOBACCO

......

## ! Curing procadures are as much an art as a science and each cure must bejudged on the basis ot tobacco condition, interval between trealment and harvest, weather and type 01 curing facility belore prescription temperature and ventflation schedules can be established. To obtain maximum quaJity, care must be taken to observe and control the curing process closely, eSpGciaHy during the lale "coIOfing" and oarly "drying· stages 01 the leal. PREprn brand Ethephon Ireated tobacco will have started the coloring processwhen harvested, reducing Ihe time required in tho coloring phase 01 curing. Treated tobacco should bedriedfaster. Iftobacco leaves are green or contain somG green when harvested, it may be nGCossary to color them lora lew hours. Jllhe leaves are comp!rttely yol!ow.temperature and ventilation must

### be adjusled in a mannerto dtythotobacco as fast as possible**w~hout** scalding. Oncethe leal is dried (3/4 dry), you should lollow J'IOrmal procedures tor curing. Since PREpl">! brand Ethephan treated loaves cure taster, treated and untreated leaves should not be cured together in the samobam. 

# 104 

# /

### I



# ... LIMITED WARRANTY AND DISCLAIMER Tho manuf,acturorwarrants (a) that this product conforms to tho chemical description on the label; (b) that this product is roasonably fj{ for 

### th& purposos sot forth in the directions fOr use when 

### if is used in accordance with such directions; and 

### eel that the dlroctions, warning and other statements on this label are based upon responsible exports' evaluation of roasonable tosls of effectiveness, 01 toxicity to laboratory animals and to plants. and of residues on food crops 

### and Upon reports of fiold experience. Tesls have not boen made on aU varieties or in all states or undor all conditions, THE MANUFACTURER NEITHER MAKES NOR INTENDS, NOR DOES IT AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES, EXPRESS OR IMPLIED, AND IT EXPRESSLY EXCLUDES AND DISCLAIMS ALlIMPUEOWARRANTIES OF MERCHANT-ABILITYOR FITNESS FOR A PARTICULAR PURPOSE. THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLElY RESPONSIBLE FOR, ANY AND ALL LOSS OR DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHfCH IS INCONSISTENTWITH THE LABEL DIRECTIONS, WARNINGS ORCAUTIONS. BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, LOSSES, DAMAGES, OR INJURIES RESUlTING 

### FROM THE USE 

### OR HANDLINGOF ll-IIS PRODUCT, 

### WHETHER OR NOT BASED IN CONTRACT, NEGLIGENCE, SiRlCT LIABILITY IN TORT OR OTHERWISE SHAU BE LIMITED, ATll-IE MANUFACTURER'S 

### OPTION, TO REPlACEMENT

### OF.ORTHE REPAYMENT

### OFTIlE PURCHASE PRICE FOR, THE OUANTIlY

### OF PRODUCTWITH RESPECTTO WHfCH DAMAGES ARE CLAIMED. IN 

### NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL. INDIRECT OR CONSEOUENllAlDAMAGES RESULTING FROM THE USE

### OR HANDLING

### OF THIS PRODUCT. NonCE 

### TO BUYER Purchase of this producf does not confer any rights under patienls governing this product or the use thereof in countries outside of tho 

# e United Stat

### os.

_ 'DEF and Guthion are rogistorod trademarks of BayerAG, Germany.

# ~ (e;, if"., ,,,.,,•.\ i \i_ .'! 

### 12.,·



# I 2Dropp 

### is a registered trademark of NOR-AM Chemical Company. :lHarvade is a registered trademark

### 01 Uniroyal Company.**~Malathlon** is atrademark of American Cyanamid Company.

RMno-Poukmc Ag Company P.o. Box t2014, 2 T.W. Aloxandor Drive Research Triangle Park. North Carolina 27709 PREP isthe tradomark 

### 01 Rh6no-Poulenc. FOlEXis a registered trademark of RhOno·Poulonc

. 

### ACCEPTED 

### wi1:h COM['.l1::NTS ill EPA 

### I.cHef DMe<i:

## :\P(~ 

# S ,(',("0

'1, '-.**t!~,** 

### i"'-CCr:-ll**Ir-;~<ctl(de ,J-,~,** **m)~** 

### R0dcmic(;e Act 

### -':**-~dzd,** 

### kr the pesticide

,**,}'~ :f"~**  

## unc!er EPA**F~g.**

### No. 9(";/

- 

### '..i/

### ~.' " 

# ."**~-** ,

PREpfM brand Ethephon tor Cotton and Tobacco (PENDING) Submitted 3122193. 

## • 

# .,.

• • • • 

## ••



# ·**~**

# ..

• 

# .

, 

# . ., 

# . • ••

• 

## ••• • ••



# .

, 

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# 105

# ....**~.** 

# ·
., • • 

# . ..**~**

# ..

• 

## •



# ••

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### • 

### •

## •••• • 

# .

.......



# ·

.



## • •••••



# • •••

## ,------------------------ 

# --_

.......

## _---



# •

• Mr. Warren A. Davis Rhone-poulenc Ag Company P.O. Box 12014, 2 T.W. Alexander Drive Research Triangle Park, Me 27709 Dear Mr. Davis: Subject: Add Use on Tobacco 

## PREP Plant Regulator for Cotton EPA Registration No. 264-418 Your Submission Dated December 7, 1992 The amendment referred to above, submitted in connection with 

## registration under section 3(c) (7) (A) of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), is acceptable provided that 

## you: 1. 

## Submit/cite all data required for registration/- 

## reregistration of your product under FIFRA section 3(c) (5) or 4(a) when the Agency requires all registrants of similar products to 

## submit such data. 2. submit one (1) copy of your final printed labeling before you release the product for shipment. If these conditions are not complied withr the registration will be subject to cancellation in accordance·with FIFRA section' 6(e). Your release for shipment of the product bearing the amended labeling constitutes acceptance of these conditions. A stamped copy of the label is enclosed for your records. The additional brand name "PREplW Brand Ethephon for Cotton and Tobacco" is acceptable.

Enclosure sincerely 

## yours r



## Cynthia Giles-Parker Product Manager (22) Fungicide-Herbicide Branch Registration Division (H7505C)



# 106

# •

• Mr. Warren A. Davis Rhone-Poulenc Ag Company 

## P.O. Box 12014, 2 T.W. Alexander Drive Research Triangle Park, NC 27709 Dear Mr. Davis: Subject: Add Use on Tobacco 

## PREP Plant Regulator for cotton EPA Registration No. 264-418 Your Submission Dated December 7, 1992 The amendment referred to above, submitted in connection with registration under section 3(c) (7) (A) of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), is acceptable provided that 

## you: 1. 

## Submit/cite all data required for registration/- reregistration of your product under FIFRA section 3 (c) (5) or 4 (a) 

## when the Agency requires all registrants of similar products to submit such data. 2. Submit one (1) copy of your final printed labeling before you release the product for shipment. If these conditions are not complied with, the registration will be subject to cancellation in accordance with FIFRA section 6(e).' Your release for shipment of the product bearing the amended labeling constitutes acceptance of these conditions. A stamped copy of the label 

## is enclosed for your records. The additional brand name**"PRE~llI** 

## Brand Ethephon for Cotton and Tobacco" is acceptable.

Enclosure sincerely yours,

Cynthia Giles-Parker Product Manager (22) Fungicide-Herbicide Branch Registration Division (H7505C)



# 107

# ---- -_._-_._--



# •

• PREP TM

# BRAND ETHEPHON FOR COTTON AND TOBACCO
For Commercial Use Or Agricultural Use Only. Not For Residential Use ACTIVE INGREDIENT: Elhephon (2-Chloroefhyl) phosphonic acid"

........................................................55.4%



### .....................".,

..............,......,.................................................................,..........44.6°4 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO
PRECAUCION AL USUARIO: 51 uSlod no 100 inglos. no USG OSlO producto hasta que la informacion on la otiquota Ie haya sida 8xplicadc ampliamonfo. 

### For MEDICAL And TRANSPORTATION Emorgencles 

## ONLY Can 24 Hours A Day 1-800-334-7577 

### For 

## eRQ!>!!!,T J.!.S.C. Information Ca" ,·800·334·9745 Tho use 01 this product lOT a variety of plant growth regulalion uses are prof.ctod by United States and loreign patonts includ[n U.S. Patents 38.791.188 and 4.240,819. No license is 9ranted 

### to use this product in countries other than the Unked States or lor an use not contomplated by this labol. LiabHity for patent infringement may result Irom use or sale 01 this product outslde Ihe Unite States. 

# STATEMENT OF PRACTICAL TREATMENT IF IN EYES: Hold eyelids open and Ilush wilh agentle stream of water for at loast 15 minufos. Get medical attention, preferably an ophthalmologist. IFON SKIN: lmmediatoly wash skin wilh plonty 01 soap and water. Remove contaminatod clothing and shoos. Wash clothing separately before reuse. IF SWALLOWED: 00 not induce vomiting. Promplly drink a large quantity 01 milk, egg whites, gelatin solulion or if these are not available. drink largo quantilios 01 water. Avoid alcohol. CaB a physician immediately. IF INHALED: Removo vlclim to fresh air. II nor breathing, give artilicial respiration. Administer oxygen if neCGssary. Get medict;ll attontion. 

# J PRECAUTIONARY STATEMENTS DANGER HAZARDS TO HUMANS AND DOMESTIC ANIMALS CORROSIVE. Causes eye and skin damago. May

### befatal 

### if absorbed through SKin. Harmful 

### if swallowed orlnhaloo. Avoid broathir.g spray mist. Do not get in eyes, on skin or on clothing. Wearfull lenglh trousofS, 

### long $leevod shirt, protective glovos, and goggles or tace shield when handling. Change 

### to clean work clothes dally. Wash thoroughlywl1h soap and waler after handling and be/Ofe 

### nUng, or smoking. Romove and wash contaminatad clothing belora reuso. 

### Koop away from domostic animals. NOTE TO PHYSICIAN Thoro is no specific antidote. All troatmont shouk! be based on obsorved signs and symptoms 01 distress in the patlent. Overoxposut< 10 materials othor than this product may have occurred. V"lCtlms 

### 01 severe overexposure. by inhalation, should bo kept undoi' medical observation for up to 72 hours for delayed onsot

### 01 pulmonary edoma. In a victim ofover-exposure by ingestion. carolulgutriclavage is required duo to tho possibility of stomach or esophageal perforation. This materiaf is an acid, but use 01 alkaline sub$lancos to noutralize it}s contraindicated. 

## ENVIRONMENTAL HAZARDS 

## • • •••••• • 00 not apply directly towater, to aroas whero surface water is present orto intertidal areas below tho moan hifilwal.rmark. conlaminato waterwhen disposing of equipment washwaters, : ••:.: •• 

### • 

# •• 

# • Do not contaminate water used lor irrigation ordomestic purposes. 

### • • •••••• • • 

## USE PRECAUTIONS • • •• •

## •• 

# • •• 00 not apply PREprw brand Ethephon GoUon Boll Openor through any typo of irrigation system.••••• 

## • • ••• Do 

### oot

Avoid spray drift to nearby crops as this product will cause modificalions in plant growth. Plant 

## IniQI)'P roducod ,lelds

### will result. 

### 00 nor plant another crop within 30 days alter troatmonl. Mix only the amount of spray you expect to use each day. 00 not allow mixod solution to stand ovornight. 

### • 

## •• 

## •• •



## ••••


# ., 

# . . , 

# . • 

# •• 

# 108

# •

• DIRECTIONS FOR USE It Is a violation of Federal Law to us. thIs product In a manner Inconslstont wIth fl9 

### labeling. Road onUro label boforo usIng thIs product. 

## REENTRY STATEMENT Mixors, loaders and applicators musl woar a full face shield, 

### long trousofS, long sleeved shirt, glovos and boots to avoid as much skin 

### and ova contact aspossiblo. 

### Do not enlertreated fiolds within 24 hours ahar application unloss protoctive clothing is worn.



### STORAGE Do not contaminate water, food. orfoed 

### by storage or disposal. 

### If contafnor is brokon orcontents have spilfod, follow aD precautions indicated above and clean up Immediately. Boloro cleaning up. put on full length trousOn>. 

### long**slo~wed** shirt, 

### protective gloves, and goggles or laco shiold. Soak 

### up spill**w~h** 

### absorbent media such as sand. Garth or other suitable matorial and dIspose of wasta at an approved waste dIsposal facility. PESTICIDE DISPOSAL Pesticide wastas are acutely hazardous. Improper disposal 01 excass p&$ticide. spray mixture. or rins4te is ill violation 01 Federa! law. IIthese wastaS cannot be disposed 01 by us. according to lalrol instructions, contact your State Pesticide or Environmental Control Agency or the Hazardous Waste representative at the nearest EPA Regional Oltica for guidance

. CONTAINER DISPOSAL Triple rinse (orequivalent) the empty containers. Then offer lor recycling or roconditioning. or puncture and dispose 01 in a sanitary !andlill, or b incineration or It a!lowftd b stato and local authorities, burnin If container is burned. sta out01 smoke. 

## GENERAL INFORMATION COTTON A loliarspray 01 PREpr!oI brand Ethephonwill accelerate opening of mature unopened cotton bolls and enhance deloliationwhich can result in earGer harvest with an increased rocovorabl.e yield. PREP'I')I brand Ethephon treatment on cotton allows increased efliciency lrom a once-over harvest. TOBACCO {FLUE-CURED}: A loliar spray of PAEpnt brand Ethephon promotes &arly, uniform "yellowing- 01 mature Iobacct PAEpm roduco! curing timo, aI/owing moro efficient use 01 curing barn space, and increasedcontrol ovor haNGst schedules. SPRAY PREPARATION Add 112 

### to 314 ofthe required amount of water to tha spray tank. Stan agitation, Add the requIred amount 01 PREpru brand Ethephon. and the remaining amount 01 water. Prepare only as muCh sprOlY solution as can be used on the dayof mixing, Do not allow spray solution to stand overnight. Do not 

### spin the concentrat&d product on spray aquipment, or any airplane parts. ANYSPIUSSHOULD BE RINSED !MMEDIATELYWITH PLENTYOFWATER. Use 01 a nurse tank is highly recommonded lor avoiding possible spills 01 concentrated lormulationon spray equipment orany airplane parts

. COMPATIBILITY PREpm brand Ethophon is compatible with DEFl, FOLEX®,

## DraW, Harvade:l· MethYl Parathion, Guthion\ and Malalhion4

, and may bE awfiod in soquooce oras a taflkm((turo (DO NOTTANK MIX WITH DESICCANTS IFCOnON IS TO BESPINDLE HARVESTED). In some cases slight reduction in 

### boU oponing respons.o has baon observed whontank mixes with deloliants were used. 

### Good agi1ation in the spray tank ia. essential and a tank mixture should not bo allOWed to stand without agitation lor more than 5to tl minutes, Read and obsorve all appropriate !abel use directions and precautions lorthe defoliants and insodicides used. NOTE: Under cortain conditions, tank mixtures 01 PREpru: brand Ethepnon with daslccants contaIning sodium chlorate could rasun in the formation 01 hypochlorous acids which on hoating 

### will emit toxic chloridefumes. EQUIPMENT CLEANING Because ofthe acidic nature 01 this product. prolonged oxposuro to spray deposit

### will damage acrylic plastifp.flti1"in paints, and motals. • Rinse thOroughly with a detergent and water all exposed acrylic plastic·type materials (e.g.• aircraftwindshi"!i.).llpd painted surfacoE withIn an hour after exposure to spray doposits. :

..:.: ••• At the end of each day, rinse thoroughly with a detergent and water all tho motal pMs 01 tho arrcMh and the assoda!ed spray equipment exposed to the spray deposns. Ao:.:EPTED •• : •• : 

### will> COMMENTS •••• In EPA Lcttl."f DtlIt.:d: ••••• 

## • • • 

## • ••••• 

# .. 

# . • ••



# .. 

# .

• 

# · .. ., 

# . •••• 

# .. . •• • 

# · .. 109

# •

• COTTON

EXPECTED 

### PREprw ONE SPRAY VOLUME APPLiCATION 

### USE CONDITIONS 

### RATE GALLON (Gals/A) 

### TIMING 

### PAEpnl TREATS 

### Plnts/A LBS A.I. Acros Ground 

### Air" 

### PREprn Hot and dty SooFor 

### 1113 1.0 6 Apply 

### when the number 0: Boll Oponer- higher 

### malUr; unopened bolls is 

### 01}'and 

### 75 10

### SO"F 

### 2 1.5 4 15 50 2·5 $ulliciont 

### 10 produco the doslrod crop. S&8 

### below lor 

### Coolbut 3lxwo 

### 65G

### F 2213 2.0 3 

### tost 01 boll maturity. Treatment uniformly opens: 

### Rankcotton 2213 2.0 3 bolls 710 14 days Garlier. 

### PREpN + 

### High soU moisture 

### 113 0.25 

### 24 15·50 5·10 

### Apply 4 to 

### 7 days prior Ie 

### FOLEX· High farli61y lovel 

### PREpm boll oponlnf: Dofollant Tank 

### Rank cotton application. To bo uslXl as 

### Mix a soquontiaJ Iroatmont with, 

### not in place 01 

### PREpN boli 

### oponina treatment

. PREpt'M+ Dropp2 

### High soil moisturo 

### 113 0.25 

### 2' 

## to- 50 3·10 Apply .{ to 7 days prior te 

### Dofollant Tank 

### High lanility lovel PREpN boll oponing 

### Mix Rank cotton application. To 

### be used as 

### a soquantial troatmont wnh, not in placo 01 PREPrw bol! oponinO treatmont.**Pr.~Condltlon.r** Hoi. dry. above 

### BO"F 

### 213 0.5 12 Apply 4 to 7 days prior te 

### for Defoliation 

### Cool, abovo 

### SSGF 

### 1113 1.0 6 15·50 

### 2·5 doloUant. Enhances top crop dolollation raducins Rank CQlton 

### 1113 1.0 6 doterioration 01 bottom crop 

### and allows 

### lor earlior

. halVest. 

### ·Pretreatment With DefoUants Prior to PREpn! Boll Opening Treatment If the cotton is overly rank or laying down in the mlddlos and good spray coverage 01 the bolls with PREpm Is dilticult, a pretroatmen with detOliants

### willbe uselulto improve 

### boll coverage with**PAEP~.** 

### Us. dosage ratllS 01 PREpm brand Ethephon Colton Boll Opener recommended tor 

### bollopening. Read and obselVe 

### all appropriato labol use diroctlons

### and precautIons lorthodololianl used. ""In California 

### and Arizona use avolume of no lass 

### than 5 gallons por aero lor aerial applications. 

### Boll Maturity Aboll 1$ mature when itistoo hard to bedentedwhen squeezed botNeen thumb and lingers, tOO hald to be slicod with asharp knife, an, when Ihe seed coat becomes Ught brown in color. 

### Use limitations 

### Do not oxeood 

### a maximum 01 2.0 lb. a'ilAforcombined uses 01 PREpn.! por acre paryellr. Boll OpGning: Do nottank mix PREpt>I brand Ethophonwith a desiccant iftho cotton is to be spindle haNosUt<i, Pro·CondltiOn for Defoliation: Do nottank mix PREpu.. with desiccants unloss plant desiccation is required. Do not use a delollan belore there is suHlciont mature unopened bolls to produce the dosfcod yiold (sea Gonerallnformation section on how

### to tost lorbo maturity. 

### WHEN TO HARVEST COTTON 

### • • 

### •••••• Do not harvest cotton soon&!' than 7 days after a troatmont with PREpn.! brand Ethephon Colton Boll Opener.· ObSONO tho troaled crop and harvest when optimum boll opening has been reached. Too early harvost migh'reducI tho full advantagl 01 tho troatmanl and too late a harvost may result in reduced quality and loss of lint which will dmp**rr8~thQ** ptant. •• 

## • •• 

## • 

## • • •••••• • • • •



## •• ••

## ••• • 

## • • 

## • ••••• " 

# . • 

## ••

•• • • 

## • 

# •• •• •



### ••••


# .

, 

# . . , 

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# 110

# •

• PREpnt Crop Situation 

### PlntslAcro
Dirocted Spray 

### 11/3 Application

Ovar·Tho-Top 

### I t/3-22/3 Application

USE LIMITATIONS 

# tOBACCO (Flue·Cured Only)
Spray Volume Gallons! Spoclflc Dlroctlons

Acto 

### 50 ·60 Uso drop nozzles. Choose TG or OC spray tips designed 

### to apply 50 • 60 

### gpa at 35-40 

### p,1 and 

### at tractor speed 

### 01 

### 2·3 mph. 

## U

.. 2 nozzles por row; ono on each side altho row dropped low enough 10 direct the spray 10 tho loaves to be ripened and harvesled. Thorough spray coverago 

### is essential. WIth a directed spray, be 

### sur. 10 haNas! alllGavos 

### with 20%ormore vollowina. 

### 40-60 Troal only whon leavos remaining on tho stalk ara maturo. To ensure 

### romaining loaves aro maturo. test spray soveral tobacco plants as described undertho soction ·Propor Timo 01 Treatment.· Us. tho Iowar rata in a normally mature crop whon oxporionco indicateS that minimum ripening inducement\$ requiJed. U;.e the higher rata when tho cropfs heavy and has 

## a tendency to be more rank or when temperalures are lower than normal. Always test spray to determine 

### If tho tobacco is mature enough to respond totreatment with PREPn.t brand Ethephon. Apply over-the·top PREprw: brand Ethephon spray as 

### a tine mist using throe nozzles (ono nozzla tips overthe center01 the plant, and one on each side) so all leaves are covered thoroughly, similar to the applicalion pattern 01 systemic sucker controt agents. Use 

### a soray prossule 01 

### 40 to 

### 60·psi.

Do not apply PREPN brand Ethephon to immaturo leaves 

### as this can resuft in unsatlslactory coloring, waightloss and reduced laal qualily. 

### Do not allow the crop to over ripen in the field after using PREpnt brand Ethephon, since this maycause some reduction in ylold and quality. Do not treat boforo anticipated major storm which could provent halVost and rosult in crop 

### loss. d 

### 00 not apply PREpnt brand Ethephon if rain is e)(pected within 

### 4 hours. APpLtCAnON nMING Successful results with PREpnl call lortroatment whan loaves are mature, not overly rank green when sprayed. To easUy dotormin, the proper treatment timing and the number olleavas p&r stalk ready lor halVest, test spray several plants in more than on. location if each field and obselVe tho response. Maluro I&aves

### will begin toyoHow in 24to 72 hours. Test loavesthat fail to yellow in 72 hours ar, nol mature and are not ready for PREprw brand Ethephon treatment. Wait a low days to permit lurther natural maturing, then mak, anothertest spray or**~maturity~** check. Whon you havo conlirmGd the number olll!aves per plant that win color. 

### you can determino the number 01 acres to troat in order to II tho barn. Preparo your testspray by mixing one teaspoons 01 PREPnI In 1 quart 01 water. Spray Ctach tost plantwith abol1\ 1 oz. 01 this mixtur& covoring aU leaves with a lino mist. PREfmI brand Ethophonwill notcolor immature sprayGd leaves. WHEN TO HARVEST All mature, sprayed loaves will begin to color within 24to 72 hours aller PREpnt brand Ethephon application. Tho yellowing proctlss is weather depaooent; cool wealherwill delay,**w!J~e** hot, sunny weathor can speed up th& process. Harvest treated tobacco when leave: havo reached the desired color intensity. 00 not allow tobaCO') to bllCOme ovor ripe belore starting halVOSl Leal dropcanoccurwhen tobacco is OV8r ripe and loft onthe stalk If a numbar oftho bottom leaves have yellowed atthetime oftreatment, they should bo halVest&d prior to spraying with PREP"N brat1( Ethephon. • • With an over-tho-top application, harvesting can commence 24 hours aftar PREpnoi brand Ethephon applicaKOnd;p.nding on woathe conditions or

### to avoid over ripe tobao:o. Tobacco harvested 24 hours after treatment will roqulro more time i.,.hecoloring phaso olthr curing process. •••••• : •••• 

## • •• CURING PREpn. TREATED TOBACCO : .: • Curing procedures are as much an art as a science and oach cum must be judged on the basi• .s:VJQQacco condition, intorval betweer treatmont and halVest, weather and typo 01 curing lacility belore prescription temperatureo ani ventilation schedules can b£ established. To oblain maximum quaUty, ca.ro must bo taken to abSOlVe and control tho curing prH&!I.$**clo$CI~.** (lsp&cially during thr late**~coloring~** and early**·drying~** stages 01 the loa.f. ••••• • •• •• PREpni brand Ethephon Ireated tobacco will have slarted the coloring processwhen

## harvestod,~ tho limA requirad in the**~Iorlng** phase 01 curing. Trealod tobacco should be dried laster. 

### If tobacco loaves are green orconlaln so$

## 9MJl when halVastod. It may

### be nGCGSSarytocolarthom lorafGW hours. II the leaves are complelety yollaw. temporatura andvontil"atil:m*must be adjustGd in a mannerto dry tho tobacco asfast 

### as. possible without scalding. Oncethe klaf is dried (314 dry). you thould'(.now normal procedures lorcuring. Since PREpThi brand Ethephon troatoe! loavos cure fastor. treatod and untroated loavos should 

### rdb&.GUrad togothor in tho samo barn. 

# 111

# LIMITED WARRANTY AND DISCLAIMER Tho manufacturerwarrants (a) that this product conforms to tho chomical doscription on tho label; (b) that this product 

### is reasonably 

### fi lor tho 

### purpoSG$ sot taNh in tho directions for usa whon 

### it Is used in accordanco with such diroctions: and (c) that 

### tho- directions warning and olhor statements on this label**ar~** based upon responsiblo exports' evaluation of 

### reasonabf8 tosts 

### of effectiveness, 0 toxicity to laboratory animals and to plants, and 01 residuos on lood crops and upon reports of lIoki oxperience. Tests hava not boor 

### made on all varieties or In all slatos or underaU conditions, THE MANUFACTURER NEITHER MAKES NOR INTENDS. NOR DOES 

## n AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES. EXPRESS OR IMPLIED. AND 

# n EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANTIES OF**MERCHANT~A8llITY**

### OR FfTNESS FOR 

### APARTlCUlAF PURPOSE. 

### THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND ALL LOSS OF DAMAGE WHKiH RESULTS FROM THE USE OF

# nus PRODUCT IN ANY MANNER WHICH IS INCONSlSTENTWIlH THE LABEL 

### DIRECTIONS, WARNINGSORCAUTIONS. BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS LOSSES. DAMAGES. OR INJURIES RESULTING FROMTHE USE OR HANDUNG OF THIS PROOUCT, WHETHER OR NOT BASED It\ 

### CONTRACT, NEGLIGENCE. SmicTLIABILITY IN TORTOROTHERWISE SHALL BE LIMITED. AT THE MANUFACTURER'S OPTION TO REPLACEMENTOF, ORTHE REPAYMENTOF THE PURCHASE PRiCE FOR, THE aUANTrrfOF PRODUCTWITH RESPECTTC WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL. INDIRECT OF CONSeaUENllAl DAMAGES RESUL

### TINa FROMTI-lE USEORHANDLING OFTHIS PRODUCT. NOTICE TO BUYER Purchase 01 this product does nol conler any rights under patienta governing this product or the use therool in countries outside 01 the Unltod Statos. 

# e 'DEF and Guthion aro rogistorod trademarks 01 SayarAG, Germany. 2Dropp is aregistered trademark.01 NOR·AM Chamical Company. 3HaIVadois a registered tradomark 01 Uniroyal Company.



# • 4Malathion is atrademark of 

### American Cyanamid Company

.

Rh6ne·Poul9ncAg 

### Company P.O. Box 

### 12014, 2T.W. Alexander Drive Research Triangle Park, North Carolina 

### 27709 PREP is the Irademark01 Rhllne-Poulenc for Etheplion Cotton BonOponor FOLEX 

### is a registered trademark 01 Rhone·Poukmc. PREpN brand Ethephon lorCotton and Tobacco (PENDING) Resubmitted t2l7/92. 

### • ••••• 

## • •• 

## • •• • 

## • •••••• 

## • • • 

## •

•• 

## ••••• • • 

## • • ••••• 

### • • 

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### • 

# ., . . , 

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# 112

# •

• UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D C. 20460

CHICEOF "'l[VtNT'ON. PE5T,cIDES I<NO TOXiC S'Jssr"'M:€S



## Mr. Warren A. Davis Rhone-Poulenc Ag Company P.O. Box 12014, 2 T.W. Alexander Drive Research Triangle Park, NC 27709 Dear Mr. Davis: Subject: Add Use on Tobacco I**~** 

### !**0,1"~** 

### ("**!A'-~r** 

### PREP Ethephon

### <"'Cotton Bo±l-Opener 

## EPA Registration No. 264-418 Your Submission Dated December 7, 1992 

## The amendment referred to above/ submitted in connection with registration under section 3{C) (7){A) of the Federal Insecticide, Fungicide l 

### and Rodenticide Act (FIFRA) I 

### is acceptable provided that you: 

## 1. Submit/cite all data required for registration/- 

## reregistration of your product under FIFRA section 3(c) (5) or 4(a) when the Agency requires all registrants of similar products to submit such data. 2. Submit one (I) copy of your final printed labeling before you release the product for shipment. If these conditions are not complied with l 

## the registration will be subject to cancellation in accordance with FIFRA section 6{e). Your release for shipment of the product bearing the amended labeling constitutes acceptance of these conditions. A stamped copy of the label is enclosed**for~** 

## your records. / 

## Sincerely yours,

Enclosure d "**~_/~~~7, r~**  

## Jr'**~** 

## ,**~ /"~~7~**  

# - 1:."1

### ~**_/g,~jC_** '-",**~/-'/** 

## Cynthia GrleS:parker Product Manbger (22) (**Fungicide-H~rbicide** 

## Branch Registration Division (H7505C)



# 113

# "



# •

• , 

## , 

# ti!!, RHONE-POULENC

RHONE·POULENC AG COMPANY


### December 7, 1992 U. S. EnvIronmental Protection Agency 

## Office o( Pesticide Program Document Processing Desk Room 266 A, Crystal Mall No, 2 1921 

### Jefferson Davis HIghway 

### ArlIngton, Virglnja 22202 

### AttentIon: Mr, JIm Stone Registration Team (22) 

## FungicIde HerbIcide Branch RegistratIon 

### DivISion (H750SCJ
Dear Mr. Stone: RE. 

### Prep brand EtrlephCn For Cottor. ana Tobacco EPA Reg. No 264-·1 i 

### 8
In your letter oated November 30, i 

### 992 a request was made 

### to add the statement "Do not 

### apply directly to '.vater, to arezs

## wr\ere surface water Is present or to interUdal areas below the mean hlgh w3terlT'ark" '.'Ie are Including 5 COpies 

### of amended labels wlth th15 

### statement addeo. InaddHlOn acompleted offer to pay form uSing the cite all wethod of support is appended The only reg1strant listed in 

### the most recent 

### EPA mdex of data submItters 15 

### GAF CorporatIon. 

### They shOuld 

### De deleted 

### as a regIstrant (or ethePhQn since ljtjgatlon In 

### the eariy 1980's resulted In 

### acourt Judgment that all ethephon prOduct inventOrJes 

### and data were 

### the sole property of UnIOn Carbide Corporat

### lOn, now Rhone-Poulenc 

### AS a result 

### no offer to 

### pay were actually sent 

### to support thIS aDplicat10n. VIe need this label approval very quickly to_ o'iOidd printing and DacKagmg delays (or the 1993 season. To expedite approval. 

### we are faxing toyour toaay a cooy of the cover letter, one label and the completed oHer to pay. By over night delivery servIce we will send 

### 5 amended labels, and the Original or(er to Day.
'We 

### apDreclate your aSSIstance 1n this 1rr,porta!'lt regIstration lssue. If 

### you have any Quest ions please contact Jr,€' 

### prompt

# 1, (919-5-19-23791
Sincerely.

# {j)~A~ Warren 

### A DaVIS SenIor 

### Reg1strat Ion r13flager

POBOX**IC;H~** 2rW

.... l.£XAN[)ERcqiVE RESEAACH lFi'ANGLE PARK NC 277m {\j19)549·2QOO .NTEP.NAlIONAl TELEX**Nu~-.!eER** 4!n937!J -ANS'NERSACj( APC flTr :NfERNAHON,I.l DISTRISUnQNSERVICES T£L0:NUMBER 4999217-ANSWERBACKArc iDS 

### •

## ••••• 

## • •• • •• 

### • 

## • •••••• 

### • 

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## •



# ., •••

## •• • 

### • • 

### • ••••• 

### • • 

## •••••• 

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•• • 

## • ••

•• • • 

# · " 

# ., 

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•••• 

# . , 

# . .' 

# . • •• 

# 114

# •

• CERTIFICATlOO 

# w:rm RESPECT 'In 

### CITATIOO OF MTA 

## EPA File Symbol/Reg. No. 

## 264-418 "'te of 400licadcn

__ 

## 1.:0_-2,,6.:-..:.9..:.2_ Name 

## of Product 

## PREP ETHEPHON CottO" Boll Opener
Aoolicaht•s N.-ne 

### and Address

___ 

## Rc.h.:.on;..e;..-_P-,o.:".:.le:.:n
...

c'-'-A.:;:9_ 

## CO

_'..:,'p_a_":;.Y

_____ _ 

## P. O. Box 12014 

## Research TrjangJe Park. NC 277Q9

1. This application is supported by 

### all data 

### autmitted or 

### cited in the application. In 

### addition, 

### if cite-all options are in:1icated, this 

### application 

### is suoported by 

### all data 

### in the Agenc::y's files 

### that concern the 

### properties 

### or effects of this product 

### or of 

### I1tV 

### other product that 

### is identical or substantially similar**~** 

### and 

### that is one of the types 

### of 

### data that 'oIOUld be 

### required to be 

### submitted if this application sought the 

### initial registration of a product 

### of identical or shafler composition and 

### intended uses under the 

### data: 

### requirements in effect on the 

### date of 

### approval of 

### this apr>lication. 2. I certify that. for each study cited in 

### support of this application for registration that is an exclusive use study, I have obtained 

### the 

### vritten permission of the 

### original 

### data submitter to 

### cite that study. 3. I 

### certify that, 

### for each study cited in supoort of this application for registration that is**~** 

### an exclusive 

### use study: I have obtained the written petmission of 

### the 

### original data 

### submitter to cite that study: 

## .2!. I have notified in writilYJ the**~nies** who 

### have sut:rnitted rJaU I have cited. to 

### suotX)rt this application and 

### have offered to: 

### (a) Pay**~nsation** 

### for those data in 

### accordance with section 3{cHl){O} and 

### 3{c)(2HO) of 

### the 

### Federal Insecticide, Fungicide and 

### Rodenticide Act; and (b) 

### Cc:nmence 

### neqotiat.ions to 

### detetmine which data 

## are subject to the 

### o::mpensation requirement of 

### FIFRA and 

### the II'BOWlt ard 

### ,tenns of 

### canpenntial 

### due, if 

### any. 'nle**~nies** 

### I have notified are: (O)eck ale) 

### [Xl All**~nies** 

### listed on the Pesticide DIU Sul::rnitters List for all active irqredients oontained in my product (Cit

....all 

### methoo: or cite-all option urrler selective Method). 

### (Also sign the 

### General Offer to Pay Statement below.) [1 'Iboae 

### cx:rtq;)anies WhO have subtlitted the 

### studies '«<lim I have cited (Selective methOO)

Date 

### 12-17-92 Title 

## Senjor Registration Manager



## •••••• General Offer to 

### pay; I hereby offer and 

## a:;rrfte to 

### pay 

### c:anpens4i 

### ctt:to other persons, with Agard 

### to the 

### ap\X'oval of thiS applicatiorf, to 

### "the 

## extent req\Jired by 

## FIFRA Me. 

## 3(c)(1)(0) and 

## 3(c)(2)(0). ..:••: 

# "". 

# ." j • " ) ••. 

### Dote 

### 12-17-92 Sianature 

# .1/"--'Qa",. 

# /I I./'i¢>."", Title

EPA Form (April 19851 

### • • 

## ••••• Senior Registratjon 

## Manager • 

## • •••••• • 

## •• • •• • • 

## •• •

••• 

## • ••

•• • • 

## • •• •• •



## ••••



# .

, 

# . . ' 

# . · " 

# 115**~---------------------------------------------**



# •

• UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D,C, 20460**OFPC~Of** PHtoVO<TION. ?;::5TiCmES """,0 TOXJ::: SUUSfA.NCCS



## Mr. Warren A. Davis Rhone-Pou!enc Ag Company P.O. Box 12014, 2 T.W. Alexander Drive Research Triangle Park, NC 27709 Dear Mr. Davis: Subject: Add Use on Tobacco 

## PREP Ethephon Cotton Boll Opener EPA Registration No. 264-418 Your Submission Dated October 26, 1992 Prior to approval of the new use, you must comply with Title 40 Code of Federal Regulations Part 152 Subpart E - Procedures to 

## Ensure Protection of Data Submitter's Rights by 

## choosing either the cite-Allor selective Method of Support. Please note that under 

## the Selective Method for this product, you must submit a Data 

## Listing of all 

## product specific and generic data required by 40 CFR Part 158 since this product does not qualify for the formulator's exemption. For each data requirement, you must submit or cite an appropriate study or document that a data gap exists. We have no adverse comment on alternate brand name and the revised labeling except the Environmental Hazards statement should be updated to include the following statement: Do not apply directly to water, to areas where surface water is present or to intertidal areas below the mean high water mark. We are holding the labeling in our files for this product awaiting resolution of the above issue. sincerely yours,



## •• •••• 

## Cynthia Giles-Patkdr 

## • • 

### •••••• 

### •


# ... 

# . , 

# . · 

# .. •

ProdUct Manager**f~':2)** 

### ......**Fungicide-Herb~c1dQ** 

## Brancfi Registration oi.,.i:aion**(.e:7~95C)** 

## • •

••••


# 116

# •

• RHONE.POULENC AG COMPANY**DeC(~rrber** 

### 7, 1992 U S Envlr )rIMer·tal protectIon Agency 

### Off1ce of**~'estlclde** 

### Prograrr Doc.ument ProceSS\f1g DeSk 

## Room 266 p." 

### Crystal 

## f"iall**~iO.** 

## 2 1921**Je~(~rson** 

### D3\I[5 HIghway 

## Arlington, Vlrgln!a 22202 Alt.ntlor" Mr, JIm Stone ReglstraUon 

## Teoam (22) Funglclde HerbIcIde Brartch Aeg1strat on Dlvls t

### on (H750SC)



### pn·p Dralid EtrepilOn 

### Fe,;, Cotto"18M 

### TObaCCO 

### EPA Reg No 26<4-1118
In**y::,~r** 

### letter Mtec**~·;i)veJjlbS'{** 

### 3(;, 1992 a t?Q"esr v,'as rn;':l')t' t:) 

### aed t>e 

### statement 'C-o 

### riot**app~y** 

### dIrectly to v.,atf'r, to 2'c35o**vihN~** 

### Sifface water'$Vesent or 

### tC'**!r~terl1oal** 

### areas below 

### tM rr.ear'l**hj~l** 

### water

### rra"'k" Vi:? 2te i'1Clv:1f19 

### S cODies 0f arcended labe!s- 

### with thls 

### statement 

### added !rl**a-j::il~lor** 

## a :orr.pie'ed off€',to 

## pa,! for"'G us!rlg,th'? 

## c;te a;\ "!le-t:-:oc of support IS appended 

### "f"h£,

# Oil""**r{'9istrar,~** 

### 11st£'o ';, tne most recer,t 

### E:JA jr.,ji.'i', 

### c"**tja~;)** 

### SI;C0',ltters 

### 15 GAf (O;Do,atlon ·:-htV shouid Le 

### oelHE'G as a regiSF<F,t (or 

### e-ti)epbct. 

## sir';:e 1!!igat1ofl in 

### t'lr: early 1980's 

### reSl.n',ej I;, .:: (('lIt 

### j'Jr:g"f'1;0t**ttla~** 

### 31 j 

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### pro,juc:**In''t-r.~o;~es** 

### arid data wf±:'e VHf 

### sole D:oDert/ 

## cf i,:rdo", Carbide Cornc("atI0f,. r,ovi R"jOf1e-POiJle:::: 

## AS a result roo offer to pay 'JvF'(>**;:H..~tuij~1) $f:r1~**  t'J $'",P()(lr-:**~hjs** 

### 21pDlicatlon 

## \ve ;ieeo tr,ls**l~lt.\I?l** 

## a;:;or'>.'o31 ")':/,y 

### 'J\..!Ci\;Y 

## to 2h'ofcd**!:,:-j~,:ll)g** 

## and pa>:zgmg oe:ays for 

## t'le 1993 

## seas)',; To e;.;pedlte oprro\.'al, we 

## ore fa!!):'g to

## yew**toj~y** 

### ZI COPy 

## or tl'e cover leUer,**O~ie 'ab~i**  (j:rl'::! t

.....; 

### cO'Y'pleted 

### oqH to ;:'21'1' 

### ::!y**ov~-** 

### ;-,\gN**del~'jer/** 

### servIce vH: W111 send 5 

### aTE'ilded !nbels, zrj:he- 0' \9!(la; C,rri!f**~c** 

### pay Wi: ZlJi:re:**at~** 

### ),0'1- assistance jf> 

### V'ls 'FQ0rtc'lt**~fg~stn.}~I·):'** 

### iSS!.):>, '{ yO'J nave 1'1'1/ 

### qJ;:stiOG5**})\,eas~ ':('~'** 

### toct ty

### e prOi0pt

### 1,; 

### (9-', g- 549-237";)'1



### S**lflc~rel)',** 

# WOMM'**A~** Warren A. DaVIS !ifRO}1 r_>,£_"o'J]"[" :<';'**,:~.-£q",;:;**

## ~**t1-'y'w';-rVLlI.l:~,~;;<"J:** 

# _____ """
___""
_____""_""_.""
__



# •

r Rt{ONI.I'OULENCAfl COMPANY ENVIRONMENTAl.,REGULATORY

# u l'lJl!L1CAl'l'A!ltSPEI'ARTM£l','T PO

## So, 12014,2TW AleundtrDtlvo 

### R.....,chTlia"Sl.Park.

### N,e.21109 FlU(Numbor. (9)9)549.2545 

# fAX COVERSHEET

UlIGnm

# k::"YES
__NO DATl!: 

# n; 2 1'/'-

'fO:

# ..L-,'S

...**b!Jil.,l;ryt'~** ______ FAXNO, 

# '703

- 30

# It

- 

# I if2

# S**FlIOM:.Ja.L1~** tl j 

# D4I', l> 1I!.El'HONl!NO, 

## 9/9-.>vQ-A,,>,? 'TOTAlNUMBER OFPAGES (lNCLWlNGTHIS SH!ETJ:

______ _

# --------------~~~---------------- ____________________**~M~E~S=SA~G~~~·**

# ____________________

# •

• •

# 2~1- 

# ff gUtUL •••

# .. • • • 

## • • • 

# .. • • • 

## • 

# • 

# .. ... • • • • 

# .., • • 

## •

• • 

## • • • • • • 

## • • • • • 

## • • 

## • 

# PREpTMbrand 

# Ethe"phon FOR COTTON 

# ANt> TOBAt3Co • ForCommercial Use OrAgricultural Use Only. Not For Residential Use ACTIVE INGREDIENT: Elhephon (2·Chloroelhyl) phosphonic acW , ...,' "

.... ,.... INERT INGREDIENTS: "

..""

................"

..........,,,.............., "This product contains 6 pounds elhephon pergallon. 

### ,....55.4%



### ...., .44.6%



### EPA Reg. No. 264-418 EPA Est. No. 264-PA-01 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PEUGRO

Si usled no entiende la etKjuela, busque it alguien pala que se la explique a usled en delalle (Ifyou do nol understand the label, find someone 10 explain illoyou in detail) 

### ForM;..QlQAkAnd IBANm:QBIAIlOl! Emorgencles

### 9..tl..1"Y Call 24 HoursA Day

### 1-800"334·7577



## . ______**~,**

## ________**,f2::e!391>J,l..9J~~~~~ CaB,,!:,!~~y~~~G-!i-.:~92"2937)**  

### ___________ The use ot this product ter a variety of plant growth regulation uses aM protected by United States and foreign patents mcluding US Patent 4,240,819, No license is granted to use this product in countries olher lhan the Ulliled States or tor any use not**£q!1~!!!p'~ated** by this label Uabikty tor patent intringement may result tram use or sale ot this producLoutslcie the United States 

## FIRSTAID

c_ -,- -'-**-~'--'----',-----------------------** -- --------**-~-** -------- ----- _'

__

### I : If IN EYES: 

# I. Hold eye open and rinse slowly and gentlywithwater tar 15·20 minutes. i
1 :. Remove contact lenses, it present, allerUlefirst 5 minutes, then continue rinSing eye_ 

### 1

, , I J

__ n
________**,_l.~**

### __£all a**e..~QllS:~)ntr'9!**center or**doclo0'.2r~~advit:..e...**____

# ----------------1

: If ON SKIN OR 

## 1_. Take off contaminated clothing. : 

# , l CLOTHtNG: :. Rinse slon immediately wilh plenty ofwaterfor 15-20 mmutes_ 

## i

, I I 

### 1

__________**J~_9!I~oJ.!iQ_~**control**~r** doctorfor IreatmenLadVlce,
_____________________

## !**~** IF SWALLOWED: 

## i. Immediately call a poison conllol cenler erdoctorfor lreatment advice. \ 1 ! I I I. Do not induce vomiling unless lold 10 doio by a poison control center or doctor I I 

# l :. Havepersansipaglassofwateritabletoswallow. 

# ! 

# l
__________**.L~_Qp_** not gillS anything 

### by mouth to an unconsciQus pers£.n
_________ _ I

- 

# 1 I For MEDICAL Emergencies Call 24 Hours A Day 1**"BOO"334~7577,** 

### I


# , ' L
____Have**th'tEroduc!..£QD!~ror** labetwith you when call1ngll polson control centcr ordEctororg0!n9191_trel1!'!lOnt!..
____**~** 

# ! NOTETO 

### PHYSICIAN: Treat symptomatically, Consideration should be given to the pOSSIbility tnal ollerexposure 

### 10 materials I : other than tllis product may have occurred_ No specific antidote is ttvailable Probable mucosal damage may contraindicale the use 

# !**~,E!.2.a~,'!1£...!!l!'!9!l**

### ______,_**~**

### __, _____, __**~**

### _____________________________________**,~J** 

## PRECAUTIONARY STATEMENTS DANGER HAZARDS TO HUMANS AND DOMESTIC ANIMALS CORROSIVE Causes irreversible eye damage and skin bums Harmtu! ifswallmved or absorbed through skirt Dc nct get in eyes_ cn skill or on c!ollnng, 

### PERSONAL PROTECTIVE EQUIPMENT (PPE) Applicators and otner handlers must wear coverallS over short-sleeved shirts and short pants, chemical resistant gloves made of any waterproc\ matenal (such as Nilnle, Butyl, Neoprene <lf1dior Barrier laminate), cnemiC<llI-resislant footwear plus socks, protective eye'l.-'ear, chemical-resistant headgear tor overhead eXposure and chemlcal·reslstant apron when doanmg equipment or mlxir.g and loadmg 

# 119 

# ... • • 

## • • • • • • • 

## •

# •

• ••• •• • • 

# • • • • 

# •• • • • 

# • • •• •

## •• 

## • • • 

# • ••• 

## • • 

# • D!scard clothing and other absorbent materials that have been drenched or heavily contaminated with this products concentrate. 

### Do not reuse them 

### Fonow manufacturer's instructions for cleanlngimaintajning PPE. If no such instn;ctiollsJor washabl,¥, use detergef\l



## .... 

# .. 

# . and hel water, Keep andwash PPE separately from QUler laundry. • • • • • • : : lNhen handlers use dosed systems, enclosed cabs, or aircraft in II manner that meets the reqwements..'Isied in the

### ~~&:er**Pr~tect¢ln:** Standard tVVPS) for aglicultural pesticides {<lO CFR 170240 (d) i4-6)J. the handler PPE reqUirements may be reduced**~r** modified 

### a\ speCified in the WPS 

### UserSafety Recommendations Users should wash hands before eating, drinking. chewing gum. uSing tobacco or using the tOtlet. Users SllOUId remove clothing immediately ifpesticide gets inSide. Then wash body thoroughly and put on clean clottling. Users should remove PPE Immedialely after handling Ihis product. As soon as possible, wash thoroughty and change inlo clean dothmg Wash the outside ofgloves before removing. 

### ENVIRONMENTAL HAZARDS Do not apply directly 10 waler, or 10 areas where surfacewater is present or 10 intertidat areas below the mean high water mark Do nOI rontammale waterwhen disposmg ofe<:/uipmentwashwaters. Do not contaminate water used for irrigation or domestic purposes 

### SPRAY DRIFT Avord spray drift Do not appty when weather conditIOns may cause drift Do not allow thm product to drift on to non-target orcas Drift may r€!Sutt III illegal residues or iniury 10 ad/acent crops and vegelation, in the form of leaf yellowmg and defoliation. To avord spray drift, DO NOT apply aerially when wind speed is greater than 10 mph or during periods oftemperature inversions. Use of larger droplet $Ilewill also reduce spray drift. AVOtDtNG SPRAY DRIFTAT THE APPUCATION SITE ISTHE RESPONSlBtLlTY OF THE APPLICATOR The interaction of many equipment-and.weather-related factors deterrn:ne the potenllal for spray drift The applicalor is responsible for considering aN these factors When maKing decisions, The lollowmg drift management requirements must be**follcw~** to avoid olf-Iarget movement ftom aeriat applications to agricultural fleW creps These requirements do not apply to forestry applications, public health uses or 10 applications using dryformulations. 1 The distance ofthe ouler most nozzles on the boom must not exceed 3/4 the length ofthe wingspan or rotor, 2 Nozzies must always pOint backvlard parattelwilh the air stream and never be pointed downwards more tha1l45 degrees Where states have more stringent regulations, they should be observed. The**~pplicator** shOUld be familiarwith and take into account the**jntorm~tion** covered in the Aenal Dnft RedUClion Advisory below 

### AERIAL DRIFT REDUCTION ADVISORY [ThiS section is adviSOry in nature and does not supersede Ihe mandatory labet requirementsj INFORMATION ON DROPLET StZE The most effective way'to reduce drift pOlenlial is to apply farge droplets The best drift managemem strategy is to apply the largest drcpfets that provide sufficient coverage and control. Applying larger droptets roouc@s drift potential. but will not ptevent dnlt If applications are made improperly, or under unfavorable environmenfal wnditions (See Wmd, Temperature and Hum;aity, and Tt'!mperalure Inversions/. CONTROLLING DROPLETStZE Volume· Use high flow rate nontes to apply the highest practicat spray volume Nozzles with higher rated nows produce larger droplets. Pressure

- Do nOI exceed the noule manufac(ure(s reconlmended pressures, For many nozzte types lower pressure produces larger droplets. \NIlen higher now rates 

### are needed, use higherflow rale noutu instead of increasing pressure. Number of nozzles· Usc the minimum number of nozzles that prOVide Uniform coverage. Nozzie Orientation

- Onentlng nozzles so that tile spray is released paraliel to the airstream produces larger droplels than other orientations and is the recommended pr(lc\ice. Significant deflection from horizontalwilt teduce droplet size and increase drift potential NOllfeType. Use a nozzle type thaI Is designed for the intended applicallon. With most nozzle types, narrower spray angles produce I(lrger droplets. Consrder USing low·drift nozztes. Solid stream nonles onented straight back produce the targest droplets and the lewest dnft BOOM LENGTH For scme use pattems, reducing the elfective boom lenglh to less Ihan 3f4 of the wIngspan or rOIDr length may further reduce dntt Without reducing swath Width



# 120 ••• 

## • •

## • • •



## •

# •

• APPLICATION HEIGHT Applications shOuld not be made at 3 height greater than 10 leet above the top of the target ptants unless a greater height is required for aircmft salety. Making applications at the lowest heighl!hal is sale reduces exposure of droplets to evaporation and wind SWATH ADJUSTMENT lNhen applications are madewith a crosswind, lhe swa!h will bedisplaced downwind. Therefore, on the up and downwind edges ofthe fiefd, the applicator should compensale for this displacement by adjusting Ihe path of the aircraft upWind. Swath adjus!ment distance should increase, with Increasing drift potential (higherwind, smaller dropS!, etc.) WIND Dnft potential is lowest between Willd speeds of 2**~** 

### to mph. However, many factors, including droplet siZe and equipment type determine dnft potential at any given speed Application should be avoided belOW 2 mph due to variable wind direction and high Inversion potential. NOTE- Local terrain can infiuence wind patterns. Every applicalor should be familiar with local wind patterns and how they affect spray drilt TEMPERATURE AND HUMIDtTY When making applications in lew relative humidity. set Up equipment to produce !argerdroplels to compensale for eVaporation. Drop1e! evaporation is most severe when conditions are both hot and dry. TEMPERATURE INVERSIONS Appflcations should not occur dUflng a temperature inversion because drift potenlial is high. Temperature inversions restrict vertical air mixing, WhiCh causes small suspended droplets to remain in a concentrated cloud, This cloud can move in unpredictable dit"ections due 10 tho: kght vanable windS common during inversions. Temperature inversions are Characlerized by Increasing temperalures with altitude and are common on nighls with limited cloud cover and fight to no wind They begin to form as the sun sets and often cantinue Inlo Ihe momlng_ Their presence can be Indicated by ground fog, however, If fog is notpresent, Inveralons can alsohe identified by the movement of smoke from 

### a ground source or an alrcralt smoke generator. Smoke Ihat fayers and moves lalerally in 

### a C(lncentraled cloud {under loW WlOd conditions} indicates an inversion, while smoke that moves upward and rapidly dissip3tes indicafes good vertical au mixing. SENSITIVE AREAS The pestlcide should only be applied when the potential for drift to adjacent sensitive areas (e g. residenUal areas, bodies 01 waler, known habitat for threatened or endangered speCies, non-target crops) is minimal (e.g. when wind is blowmg away Irom the sensilive areas.) 

### USE PRECAUTIONS 00 not apply PREp-ru brand Ethephon for Cotton and Tobacco through any type 01 imgatioll system AVOid spray dnft to nearby crops as this productwill cause modllications in plant growth. Plant irljury or reduced yields will result Mix only the amountof spray you expect to use each day. 00 not allow mixed solution to stand overnight 

## DIRECTIONS FOR USE It is a vlolntlon of Fodcrallawto usothis product In a mannerInconsistentwith Its labeling, Do notappty this product In a way that will contactworkers orother persons, either dlroelly or1hroughdrift. Only protected

handlors may be in tho area durlng apPlication. For any requirements speclnc to your StateorTrlbe, consult1he agency rosponslble forpostlclde rogulatlons. Read entire labol befoTO using thl$ product. 

### AGRICULTURAL USE REQUIREMENTS

-Use ihis product only in accordance with its labeling and with the Worker Proteclion Standard, 40 CFR part 170. This standard contains 

# I reqUirements for the protectIOn of agncultuml workers on farms, foresls, nurseries, and greenhouses, and handlers of agricultural pesticides. It contains requiremenls for training, decontamination, notification, and emergency assistance, It also (:ontams speCIfic Instructions and exceptions pertaining 10 the slatements on this label about personal protective equipment {PPE), notlficalion to workers and restricted..enlry mtCfVals, The reqUirements in thiS bOll: only apply to uses ofthis product that are covered by the Woriler Proteclion Standard 

# I DO not enter or aliow worner entry IOtO treated aress dUring the restricted-entry mlervsl IREI) of48 hours. The REI IS 72 hours in areas _where average rainfall is less than 25 indles per year_ PPE required for early entry to treated areas that is permitted under the Worner Protection Standard and tha1 involves conlact with anything that has been lreated such as plants, soil or water Is coveralls over long·sleeved shirt and fong pants, chemical reSllltant gloves made 01 any walerproof material, such as**nlln~,** butyl, neoprene, or barrier !aminate, chemical resislant footwear plus socks, "nd protective eyewear. For overhead exposure, chemical-resislant headgear is also requited.**l~Ellfy** workers ofthe application by warning Ihem orally and posllngwarning signs at entrances to**~rea!,,'~d,."ree'e'c·** ________1



# 121

# •

• STORAGE AND DISPOSAL 00 not contaminate water, food, or leed by slorage or disposal. PESTICIDE STORAGE Store In a ceol, dry place and away from food, feed and other pesticides, IF SPILLED: Ifcontainer is broken or contents have spitted, follow all precauuons indicated above and clean up immediately, Before cleaning up, put on fun length trousers, tong sleeved 51))r1. protectNe gloves, and goggles or face shield Soak up spill wHh absorbent media such as sand, earth or olher suitable malerial and dispose ofwaste al an approved waste disposal faCility, PESTICIDE DISPOSAL Pestclde wastes are acutely hazardous Improperdisposal of**e~cess** pesticide, spray m!xlure, or nnsate is a violation 01 Fe<.!erallaw If these wastes cannot be**d~posed** of by use according 10 label instructions, contact your State Pesticide or Environmentat Control 

# ! Agency orthe Hazardous Waste representative at the nearest EPA Regional Office for guidance, CDNTAINER DISPOSAL Tnple rinse (or equlValenl) the empty conlainers. Then olfer for recycling or reronditioning, or puncture and dispose ot in a sanrtary landfill, or by mClflemlion or IfallO'Ned by stale and 10CitI authorities, by burning tf container is burned, stay out of smoke, RETURNABLE

-- REFtLLABLE CONTAINERS After use, return the container to the point of purchase or designaled Iccalioll$ This container must only be refilled with PREp1" brand Ethephon for Collon and Tobacco, DO NOT REUSE THE CONTAtNER FOR ANY OTHER PURPOSE. Prior to refilling. Inspect thoroughly for damage such as Cfacks, punctures, abrasions and damaged or wom out threads on closure deVices. 00 not rellli or transport damaged or leaking contamers. Check for leaKs after refilting and before transportation Ifthe container is not being**ref~led,**

### ~turn It 10 the point ofpurchase 

### GENERAL INFORMATION COTTDN "loharspray of PREP'" brand Ethephcn for Cotton and Tobacco wJI accelerate opening 01 mature unopened cotton bolls and enhance defotiatlon which can result In eartier harvest With an increased recoverable yietd PREp

.... brand Ethephon for Cotton and Tobacco treatment on cotton attows incmased efficlImcy from a once-over hSNe;st TOBACCO (FLUE-CURED): A foliar spray of PREpw brand Ethephon for Colton and Tobacco promotes early, uniform "yellowing" of mature tobacco PREptU brand Ethephon fer Cotton and Tobacco'reduces: cunng lime, allowing more efficient use of curing barn space_ and increased coutrol over tlarvest sct\e{!ules SPRAY PREPARATION Add 1/2 to 3,'4 ofthe required amount ofwater to the spray tank Start agi(.;ltion Add the required amount of PREp!" brand Ethephon for Cotton 3nd Tobacco, and the remillmng amount ofwater Prepare onty as much spray soluHon as can be used on lhe day ofmixing. 00 not allow spray sotution to stand overnight. Do notspill the concentrnted product on spray equipment. or any airplane parts ANY SPILLS SHOULD BE RINSED IMMEDIATElY\N1TH PLENTY OF WATER Use ofa nurse tank is highly recommended for avoiding possible spills of concentrated fOlmutahon on spray equipment or any airptane parts TANK MIXTURES WITH DEFOLIANTS AND tNSECnCIDES PREP'" brand Elhephon for Cotton and Tobacco is compatible With DEFe, FOLEX®, Dropp''', Dropp® Uftrn1>.l, Gmstare, Harvadel!l, Methyt Parathion. Guthionc
, and Malathion. PREP'" brand Ethephon for Cotton and TObacco may be aWlled in sequence or as a tank mixture (DO NDT TANK MIX WITH DEStCCANTS IF COnON IS TO BE SPINDLE HARVESTED), Follow alt applicable use precautions and rate per acre recommendallons on labels of products apptied as tank mixtures or In sequence with PREP 1" brand Etnephon lor Cotton and Tobacco. In some cases slight reduction in boll opening response has been observed when tank mixes with defoliants were used. GoOd**agi1a~¢n** in the spray tank 1$ essential and a tank mixture should not be allowed to stand without agitation for more than 5 to -::0 minutes Read and observe all appropnate label use directions and pre\:au\iOns for the defoliants and insecticides used" NDTE: UNDER CERTAIN CONDIT10NS, TANK MtXTURES OF PREptu BRAND ETHEPHON FOR COTTDN AND TOBACCO \N1TH OEStCCANTS CONTAINING SODtUM CHLORATE COULD RESULT tN THE FORMATION OF HYPOCHLOROUS ACtDS WHICH ON HEATtNG WILL EMIT TOXIC CHLORIDE FUMES, DO NOT MtX PREP'" BRAND ETHEPHON FOR COTIDN AND TOBACCO WITH AMMONIUM THIOSULFATE SUCH TANK MIXTURES MAY RESULT IN FORMATION OF TOXIC FUMES,
eauIPMENT CLEANING Because of the acidiC nature of this product, prolonged exposure to spray deposit will damage acrylic plastics, certain paints. and metals


# 122

# i--

I



# •

•I Rinse thoroughly WIth a detergent and water all exposed acrylic plast/o--type malerials (e.g" aircrall windshields), and painted surfaces wIthin all hourafter eJo(posure \0 spray deposils. At the lind of each day. rinse thoroughly with a detergent and water all the melal parts of the aircraft and the associated spray equipment exposed to the spray deposrts


### COTTON


### USE EXPECTED 

### PREpIM BRAND 

### ONE MINIMUM SPRAY APPLICATION CONDITIONS ETHEPHON FOR GAllON VOLUMES TIMING COnONAND 

### PREP""**{GalsJAl~**

TOBACCO BRAND 

### RATE ETHEPHON 

### FOR COTTON 

# L AND TOBACCO

TREATS PInts/A LBSA.I, Acros Ground**Alr"~'** PREP'" brand Hoi and dry 80"F or 11/3 1.0 6 Apply when the number of ETHEPHON FOR higher 

# I mature unopened haUs IS COTTON AND Dry and 75 to BO"F 2 1 5 4 5ufficienl 10 produce Ihe 

### TOBACCO 10 2 desired crop. See below for 8011 OPCntlr"' CoOl but above 6S"F 22/3 20 3 test 01**b~1** maturity Treatment uniformly opens 

# " boll$ 7to 14 days earlier. Rank colton PREpI'M brand High soil moisture 113 0.25 

### 24 

### to 5 Apply 

### 4 to 

### 7 days prior to ETHEPHON FOA 

# " PREp'N brand Ethephon lor COTIONAND High tertlilty leve! Collon 

# M' Tobacco boll TOBACCO

### + 

# i opening applicalion To be FOLEX$ 0' 

# ",ed sequenlial 

# ., , DefoliantTank Rank cotton trealment with, not in place MIx'- ot PREP"'" brond Ethephon for Cotton and Tobacco bel! ooenina treatmenl. PREpm brand High soii moisture 113 0.25 24 10 

# I 3 Apply 

### 4 to 

### 7 days pflor to ETHEPHON FOR 

# " PREpru brand Ethephon for COnONAND Highfertility level 

### , Collon 

# a"" Tobaccc boll TOBACCO

### + Oropp 

# ! opening applicalion, To be 

# " used sequential Defolianl Tank 

# '" 

# , Mix"· Rank COItOIl 

# I treatment with, nol in place



### , of PREp'N brand Ethephon 

# I for Colton and Tobacco boll ooenlnG treatment Pro-Conditloner Hot. dry. above 213 

### 05 12 

# I I Apply 4 to 7 days prior to Itor Defollallon BO°F 1 tl3 1.0 6 10 2 defoliant Enhances top Cool, above 65"F 

## Icrop defoliallon reducing 

# " , 

# I delerioralion of boltcm crop 

# I I and allows for earlier Rank colton harvest

. • For best performance_ by ground or air application, chOOSe eqUipment and spray volumes that wJ!llnsure uniform coverage offoliage

and bolls,


### •• Protreatment With Defoliants Prior to 

### PAEpTM brand Ethephon forCotton and Tobacco Boll Opening Treatment: If the colton is overly rank or laying down 10 the mlddte'S and good spray coverage of the bolls wilh PREpm brand Elhephon for COUM and Tobacco IS dl(fjcult, a prelrealment With defolianls w'tll be useful to improve bol! coverage wilh PREpru brand Ethephon for Colton and Tobacco Use dosage rates of PREpm brand Ethephon for Colton and Tobacco recommended tor boll opening Read and observe all appropriate label use directJons and precautions for the defoliant used

. ••, Can use up 10 full label lale for eilch product

.... In Callfom!a and Arizona use a volume of no less than 5 9",lIons per acre tor aerial app!icallons


# 123

# •

• Boll Maturity A boll 

### is mature when It is too hard to be denied when squeezed between thumb and fingers. too hard 10 be shced wllh 

### a sharp kmfe, and when the seed coat becomes tight brO'

....n in color, 

### Use Limitations Do not cxceed a maximum 01 20 lb. elhephon active ingredient per acre per year through combined or repeated uses 01 any ethephon products Boil Opening' Do not tank mfl( PREP'" brand Ethephon lor Collon and Tobacco with a desiccant it the cotton is to be spindle haNested Pre-Condition for Defoliation 00 not tank mix PREplIO brand Ethephon for Collon and Tobacco with desiccants unless plant desiccation IS rcquired Do no! use II defoliant before IlWtre is suffiClcnt mature unopened bolls to produce the desired yield (see Generallnformalion scdlon on how to test for boll matunty. DO NOT APPLY PREP'" BRAND ETHEPHON fOR COTION AND TOBACCO IF RAIN IS EXPECTED WITHIN 6 HOURS_ Rainfallwithin 6 hours ofapplication may reduce product performance. Do not plant another crop wllhln 30 days after treatment. Small grains plaflted earlier than 1 month or inlercropped with the cotton crop to which PREpm brand Ethcphon for Cotton and Tobacco wdl be applied may only be used as cover crops and may not be harvested fcr food or feed PREP"'! brand Ethephon for Cotton and Tobacco may cause yellowing and growth inhibition of treated smaU grains. WHEN TO HARVEST COTION Do not harvest cotlon sooner than 7 days aller a trealment With PREP'" brand Ethephon for Colton and Tobacco. Observe the trealed crop and harvest when optimum boll opening has been reached. Too early harvesl mtght reduce the full advanlage olthe treatment and too late a harvest may resull in reduced quality and loss oflmtwhich will drop from the plant.

Crop Situation

Directed Spl3Y Appllcahon

Over-The-Top Applicaticn , PREpr'" brand Ethophon for Cotton and

Tobacco Plnts/Acro 1113 

# I 11!3-22f3

USE LIMITATIONS 

## TOBACCO (Flue-Cured Only) Mlntmum Spray Volumos Gallons!

Acre

50

40 Spocffic Directions 

# ! I

Use drop noutes_ Choose TG or OC spray lips designed !o apply 50

- 1$0 spa at 35-40 psi and at tractor speed of 2-3 mph Use, 2 nozzles per row: one on each side ofthe row dropped low enoogh to direct 

## ! the spray to the leaves to be ripened and harvested. Thorough spray

# I coverage Is essential Wi!h a d'lrected spray, be sure 10 harvest all !eaves I With 20% ormore Yellowing. Treat only when leaves remaining on the stalk are mature. To ensure remaining leaves are mature, test spray severa! tobacco plants 35 descnbed under the MC'lion "Proper Time of Treatment" Use the lower rate m a normally mature crop when experience indicates that minimum r!pening inducemenl is required, Use the higher rale when the crop is heavy and has

# I

a lendency to be more ranK or When temperatures are lower than normal Arnays :e5t spray to determine If the tobacco is mature enough to respond

# I

to treatment with PREP'u brand Ethephon for Colton and Tobacco

. Apply over-the-top PREP"" brand Ethephon for Cotlon and Tobacco spray

# I

as a tine mist ·using Ihree nozzles (one nozzle tip over the center cr the plant, and one on each skle) so all leaves are covered thoroughly, similar to the application pal\em of systemic sucker contrOl agents. Use iii spray 

## I pressure 0140 to 50 psi,

Do not apply PREPru brand Ethephon for Cotton and Tobacco 10 Immature leaves as this can result In unsatisfactcf)' colonng, Vlelght loss and reolJc-ed leafquality Do not allow the crop to over ripen In the fieid after using PREpm bmnd Ethephon for Cottcn and Tobacco, since Ihis may cause some reduclion In yield and Quality Do not treat belore anticipaled major storm which could prevent harvest and resull in crop 10$5. DO NOT APPLY PREP'''' BRAND ETHEPHON FOR COTTON AND TOBACCO IF RAIN IS EXPECTED \MTHIN 6 HOURS RainfaH wdhin 6 hours ofapplication may reduce productperformance, 

# 124

# •

• 00 not use PREP"" brand EthephOn for Cotton and Tobacco with addiUves other than recommended on this label 00 

### not planl anothercrop within 30 days after treatment 00 not exceed tl maximum of2 tbs ethephon active ingredient per acre per year through repeated uses of any ethephon products. APPLICATION TIMING Successful results with PREP"" brand Ethephon for Colton and Tobacco call fOf treatment when leaves are mature, not overly rank green when sprayed To easily determine IIle proper treatment timing and the number of leaves per stalk ready for h'If"csl. test spray several plants in more than one location ill each field and observe the response. Mature leaves wilt begin to yellow in 24 to 72 hours, Test leaves thai tail to yellow In 72 hours are not malUre and are nol ready for PREP'''' brand Elhephon for Cotlon and Tobacco treatment Wait a few days 10 permit further nalurat maturing, Ihen make another test spray or "maturity" ched<- To .wold qva1ity toss and or poSSibte leafdrop, harvest any yeHowed teaves prior 10 apptication. Use tower rates under most condllions. tlmll use of higher rates to coot (below 65F at the time of treatment) slow ripening conditions When you have ecnfirmed the deSired number of !eaves per ptant that wilt cotor, YDU can determme the number of acres to treal morder 10 fililhe barn Prepare your test spray by mixing one teaspoon of PREP'" brand Ethephon tor Colton and Tobaceo m 1 quart ofwater. Spray each lest ptanl With about 1oz. ofthis mixture, covering alt leaves with a fine mist. PREP'" brand Ethephcn for Colton and Tobacco witt not color immature sprayed teaves WHEN TO HARVEST All matvre. sprayed leaves will begin to ector WIthin 2410 72 hours atter PREpm brand Ethephon for Cotton and Tobacco apphcallon The yellowmg process is weather dependent. cool weather wilt delay, white hot, sunny weather can speed up the process. Harvest trealed tobacco when teaves have reached the desired colorintensity Harvesl can commence 48 hours after PREpm brand Ethephon tor Colton and Tobacco appliClllion. To delermme harvest timmg and aVOid quality t05S or teafdrop, ctosely monitor trealed crop and weather condllions. CURtNG PREptIA BRAND ETHEPHON FOR COTTON AND TOBACCO TREATED TOBACCO Curing procedures are as much an art as a science and eaCh cure must be Judged on the basis of tobacco condition, inteNat behveen treatment and haNest weather and type of Cllting**laci~ty** before**p~scription** temperature and venlitalion:schedules can be estabHshed, To Obt2lln maximum quahty, care must be taken to obseNt' and controt the cunng process cIosety, especially during the tate "coklrlngIT alld early**~drying"** stages ofthe teaf.

. .i.

_ i 

## Til**f';'~**,;

## '\!

## 1**~/** PREP"-' I;rand Ethephon for Cotton and Tobacco Ireated tobacco .wlll have st(lrted the cotoring process when haf\'ested. redUCIng the lime required in the cotonng phase of Ctlring. Treated tobacco shoutd be dried faster. tf lobacco teaves are green or contain some green when harvested, it may be necessary to CQlor them tor a few hours. tf the leaves are comptetety yellow, temperature and venlltat\on must be adiusted in a manner to dry the tobacco as fast as possible without scatding Once the teaf is dried (314 dry). you shoutd follow normat prOcedures for cunng. SlI'Ice PREP'''' brand Ethephon for Cotton and Tobacco Irealed leaves cure faster, trcaled 

### ana untreated leaves shoutd nol be cured fogether in the same barn



### NOT REVIEWED 

### In Accon:b.nce With PR Notice 82-2 Based on Draft Labeling Dated 

# //- :l."f-**~"o.2.**



# 125

# •

• ,

# .

IMPORTANT: READ BEFORE USE Read the enUre Directions for Use. ConditJons, Disclaimer ofWarranties and Limitations of LiablJily before using this product Ifterms are not acceplllbJe. return the unopenedproduct containeral once. By uS!I1g this product, user orbuyeraccepts the following Conditions, Disclaimer 01 Warranties and Limitations of Liabmty. CONOITlONS: The directions for us.e of this product are belie

....ed to be adequate and should be followed cateftJllj'. However, it is impossible to ellminate all risks associated with the us.e ofthis product. Crop infury, ineffectiveness orother unintended consequences may result because ofsuch factors as weather condl\lon8, presence of other malerial$, orthe manner ofuse orapplication, all ofwhich are beyond the control ofBayer CropScience, All such risks shall be assumed bythe user or buyer. DISCLAIMER OF WARRANTIES: BAYER CROPSCIENCE MAKES NO OTHER WARRANTIES, EXPRESS OR IMPLIED. OF MERCHANTABIUTY OR OF FITNESS FOR A PARTICULAR PURPOSE OR OTHERWISE, THAT EXTEND BEYOND THE STATEMENTS MADE ON THIS LABEL No agent of Bayer CropScience 1$ authorized to make any warranties beyond those contained herein or to modify the warranties contained herein. BAYER CROPSCIENCE OISCLAlMS ANY LIABILITY WHATSOEVER FOR SPECIAL, INCIDENTAL DR CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANOLING OFTHIS PRODUCT. UMITATIONS OF l.IABIl.ITY: THE EXCLUSIVE REMEDY OF THE USER OR BUYER FOR ANY AND ALL LOSSES, INJURIES OR DAMAGES RESULTING FROM THE USE OR HANDliNG OF THIS PRODUCT, WHETHER IN CONTRACT, WARRANTY, TORT, NEGLIGENCE, STRICT LIABILITY OR OTHERWISE, SHAll NOT EXCEED THE PURCHASE PRICE PAID, OR AT BAYER CROPSCIENCE'S ELECTION, THE REPLACEMENT OF PRODUCT

.



### NETCONTENTS: 2,5 GALLONS

Dropp, Glnstar. Defand Guthion are regislered trademarks and Prep and Ultra are lrademarks of Bayer, Folex is 

### a registered trademark ofArn

....acChemical Corporal'lon

. Harvllde is II registered trademalk ofUniroyal Company. ' Malalhum is a trademark ofAmerican Cyanamid Company.

Bayer CropScionce LP P.O. Box 12014, 2 T.W. Alexander 

### orivo ResearchTriangle Park, North Carolina 27709 1-866-99BAYER (1-866-992-2937)

PREpTII brand Ethephon for Cotlon and Tobacco {MASTER) Approved 11/27/02.



# 126

# •

• UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON. D.C. 20460



## Mr. Warrel'l A. Davis 

## Rhone-Poulenc Aq Company 

# NOV 30 1992

P.O. Box :L2014, 2 T.W. Alexandor Drive 

## Research 'rria.ngle Park, NC 27709 

# b.'/r**Hr~** 

# 1)'IVi.: Subjeot: Add Use on Tobacco PREP Ethephon Cotton Boll Opener EPA 

## Registration No. 264-418 

## Your Submission Dated october 26 1 

## 1992 orflCt01 I'AMt{f1O!'(, PESfICIOE& ,v.o ro)(IC lIVaslANCU



## Prior to approval of the new use f 

## you must comply with Title 40 Cod.**Oj~** 

## Federal Regulations Part 152 

## subpart E

... procedures to 

## Ensure Pre,teotior\. of Data Submitter f 

## s Rights by 

## ohoosing either the 

## cite-Allor Selective Method of Support. Please note that under 

## the Selective Method for this product, you must 

## submit a Data Listing of all product specific and genoric data required by 40 eFR Part 158 "ince this product does not qualify for the formulator's exemption. For each data**r$quirem~nt,** 

## you Dust 

## submit or cite an approprial,e 

## study or dooument 

## that a data gap 

## exists. We have no adVerse comment alternata brand name and the 

## revise4 labeling except the Environmantal Hazards statement should b& updated to include the following stat'amant: 

## Do not apply directly to waterI 

## to areas where surface 

## water is present or to intertidal areas below the mean hiqh water mark. We at's holding the labeling in our files for this product 

## awaiting resolution of the above issue..

Cynthia Giles-parker 

## product Manager (22) Fungicide-Herbicide Branch R"gistration Division (H7505C)



# 127

# •

• EPA File S'/lIIbOl/ltOo. No. 

## 264-418 OSte of aQ1:)1icaeion 

### Boll 

## Opener 

## 10-26-92

_ Of Ptlx1uot PREP 

## ETHePHON Cotton**~l1ca'nt'**

### n Nane 

### al"Kt**~rH.** __

### ...:;;Rh~o::;n:;:e..;-P..;o:..:u:.:.l**::;en~c:...;.:A.::.g**

### ..;C:,:o;,;ffi::.pa;;n;,:y

_____ _ 

# P. O. Box 

## 12014

1. 1!ti. epplicotion il II\Ip\:OI:ttd 

### by 

### all data lumittod or eittd in the appliettion. 

## In tddition, it oite-ell optiona 

## a,. iooi06ttd. thi. oppllo

..ion 

## it 

## IUpPOrte' by 

### all data in the 

## 1\0.",0)". fil

.. that 

## oonoarn tha 

### propIrti

.. or effectS**,~** 

### thil croduet or ot' aJr( 

### other pr<:duct that 

### ia i&ntlcal or 

### .uMtantially 

## .!milar. an<! thot i. 

## ona of the typ;tB 

### of data that 

## ..,wd be requitod 

## to be luhmitted if th!. oppllcotion oooght tha 

### initial rtgistration 

## of • produc, 

## of identiosl 

## or .!milar _ition 

### an<! intsOOtd utel 

## under tile data

.... j\J'''''''''nts 

## in .ffeot 

## on the 

### date of 

### approvel of this eppllettion.


# . . 2. I 

## oo,ct.!fy thot. 

## for Noh study 

### cited in Il.lpIX>rt of 

### th!. application for rogilU1ttion that is an 

### exclusive liM 

### Itudy, t haW' obtained**t~** 

### written perraitsion of the 

### orloinal data 

### sut:tniteer to 

### cit. that 

### atlXSy• 3. X**0I1~ifY** 

### that t 

### for •• ch 

## .tudy cited 

### In &UPP;:!rt 

### of 

### thi. application for reQiatrlltion that 

### i. 

## !2tan 

### exclusive \1H 

### Itt.dYf I hav. (li)taiMd thO' written 

### pormiulon of 

### the original datA lumltttr 

### to eit. that 

### atudYf 

## 2t I 

# he"'. rotified in 

### 'lfritin:; the**~nl.1** 

### Who haN. aul:::fnltted rSau I have 

### cited 

### tc:, .uccort this application and MV$ 

### offerod tot (,1 

### pay CXl'I1"!naation for 

### thoa. 

### data 

## In acoordanoe with aeotlon llcHl}(D) 

## and 31eHZHDl 

## of the 

## h<Jeral I

.... otloide. IImJlcide 

## and _tloida Act, 

## ond Ibl 

## o:mnonoe n.ootiation. 

### to detemine which 

### data 

## an: subject to the**~nsation** 

### t'eqlJ.irtll'l.nt. of 'InA an.;! 

### W !I!OJnt 

### 400 

### terms of**~nutic::n** 

### due. if 

### any. Tht**~ni,"** 

### t 

### have 

### ootitied ar&t (Checlc. ant) 

### [Xl ,Ul 

## oarpani•• Hated en the 

### PQdcide Data Sulrnitters Ust for all b:etivo 

### i1'lQt"tdients. contained in Tfq 

### product**(Ci~l tMth~**  

### or 

## cl

.....ll option under 9&lective MothodJ. (.yeo 'Ign the Go!)!rA1 

# .2ll!!: to 

## Pay BY'","",nt 

## belQ!l.1 

## t 1**~l't'loM ~i** 

### .. whO 

### ha:ve 

### .uan1ttod th_ 

### nu61.,•• which 

### I have cited 

## 19&1ectlve

...thodl

Dat.**~'-17-92**



### Date 

## ...li-17-92 Blgnloture

# ~

# tl:

# Dod 

### ",% 

## 1'1U.

. SeDlpr RegiHcHiQP J:jlnjlger

I hereby 

### off

.. 

## and ...- to pay 

### _nAtion 

### to**~~,~** 

### to 

### tha 

### approval 

# ot thl. application. to 

### tile """. 310){1)(01 """ 3(c)(2)(01- SLqnat_ 

# dJA['¥4,,,,,. 

# A= .00..<;";' Titlo Sanier 

## Ragistration ManAger

{!\Pdl Ins

## J 

# , 

# .

### , s 

# PREp T ," 

# BRAND ETHEPHON FOR COTTON AND TOBACCO For CommercIal pse Or Agricultural Use OnIX. Not 

# For ResIdential Use ACTIVE INGREDIENT: Elhephon 12·Ch!oroelhyl) phosphonlc 

### acid'

.."."."

...""

...."

.."

....".".""

...."

.."

.....55.'.% 

### INERT INGREDIEN.,.S: """.'"

....""

.... ""

...."""""""

...,....." ,..""

..."."""""'"''""'" ""

...................

### ".44.&% 

# 'ThISWUflconlaln.**~**

# pounds erhaphenpergallon, EPA Reg. No. 264·4111 

# EPA eat. 

# No. 264.PA:.!1.l

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO PRECAUCION AL USUARIO:Sl 

### uSlad no lOG Ingles, no us/) Gsl& produClO hasla. C{uo Ie In!ormaclon an la eHql.lota 10 haya sldo o:.:pHcado 

### amp!l.monto. 

## For 

# MEDICAL Alld 

# rBANSpOBUTrOtl Emera.nol•• 

# ONLY Carl 24 

# Hour. A Day 1-800.334.7&77 

## For Information 

### Call 1·800·334·9745 he U$G 0 I is pro \.Ie! or a venaty 0 anI growth reg;;la! on uses are protected 

### y n 

### ed latos and ore gn patents nduding 

### U,S, Palonts 38,191,188 llf:d4,240.8t9. NO' 11000$9 

### !,**glarrt~d** 

### to utO Ih1& plodU¢t 

### In 

## counulos other than tho United Slalos or for any Utili flO! 

### contlmplaltd 

### b, this labaL liability lOr pat&r.t inlringGmont 

### may tesult from 

### uso 

### or 

## uJe of

### this product outside the Jnhod .tatllS. 

# STATEMENT OF PRACTICAL TREATMENT IF IN EYES: 

### Ho:d W&llda 

### open ard 

### tlush**w~h** a**g'!'lt~a** s\leam 

### ot wator tor**atlea~** lS 

### m\nU'&$, GGt mod(eal**a1\a1'l~ion.** 

### preiel&btl an 

### oph:halmologlst, IF 

### ON**SKIN~** 

### Immediatol,

### wash skin 

### w;',11 plenty of soap 

### a!'-o water, 

### ROn'.oVG contamlna\od olothlng 

### and IIhoo!i, Wash clothing tepalstElly bofote reUse, IF 

### SWALLOWED, 00**n~tlndue.** 

### vomi:!ng, 

### Prompfy drti'lK 

### a lorgo quantity of

### milk. GOO whltat, QGtat:" sotut:On or It thou 

### are not I1vellab!a, drink largo QUBlltiti9$ ofwater, Avoid alcohO'I, Call a phYSician**ImmQdic~oly,** 

### IF INHALEO: Romov. v.ctim to !ro!lh air. 

### If not bt03tl)ing, gtvt 

### arillicial fGsp:ratlon, Admlnls:ot oxygen 

### if naCfssary, Gat medical allentlon, 

# PRECAUTIONARY STATEMENTS DANGER HAZARDS TO HUMANS AND DOMESTIC ANIMALS CORROSIVE, Causes eye 

### and skin da'1'1&go. 

### May bo ilit$.: 

### II ab-sorblXllh'Qugh 

### skin, Harmful II swallowed Ot 

### Inhaled, 

### Avoid broaH:ng 

# e ay mls\. 00110\ 

### get in 

### iyes, on skin oron clothing. Weal to/Ii length iroU$8IS:, long sllllGved shirt, protective glovQs, and goggl-u ot eshleld when handling. Coange to clu.-"l work dothGS 

### daily. Wash thoroughly with soap 

### and watet after 

### handfrl1iJ and bEifOla SAling, Of&mok!ng, Remoye and wash conta1'llnat&d**clo~!'-!ng** 

### befolQ rause. Keep away from do:nestic animals, 

### NOTE TO 

### PHYSICIAN Thore 1$ no spoclflc MtldNe. Ali troatmGr.! shoiJld bG based 0') cbnI'Vfld sigr>; and symp10ms 01 dhulGU In tho patiQrtt. Overoxf=osur. to matorlals other than Ihh product may 

### have OCCUIIOd, 

### Victims- ot Javor.**ove(exp-~.I.;r.,** by 

### IlihalaHon, should 

### 00 kOPl under mi:HcaJ obsorvailon tor up 

### \0 72 hours 

### for dolayed ontot ot pUlmonary &<fllma. In a";dim of over-exposUfo 

### by 1"\18$tion. C91elul g<)&lrlc-Iavag& IS requlrod due to tlto possibUHy of Gt-omach o· esophagul perforation, Th;1I 

### mat!)lfa! i& 

### an acid, bt.t USI) 

### ot a!kallna 

### substan<:&s to M(.Itrnfiz$-1\ Is**CQn~ralndlcai9d,** 

## ENVIRONMENTAl. HAZARDS Do not apply dl.Gctly to waitt, to areas 

### where sJ!lace- wa!"r 

### IS pruent or to :r!llH'lidal 

### area$ be\ow the 

### mean high water 

### marK 00 nut contaminate waler

### when elspo#lng 

### ofoqulpment wt\$hwalqrt, 

### Do not contamlnato wat&r 

### uscd fOI btlgation 

### or dom&slic purpO$$l, 

## USE PRECAUTIONS Do not 

### npp-Iy PAEp1'Io! brar,d Elhophon: Colt01 

### BoH Opener through any tyiXl' ol1rrlQat1-on ;YSt9:n. Avoid &pray drl, 10 naarby crops as 

### th:s**p~oduct** 

### wi!: causa modificaF::ns in 

### plant I)lo',',1n, Plan! InjJty 

### or reductdyields

### will resull, 00 

### not plant anothor OIOP w1:hin 30 

### days aftor

### wumnen!. Mix Olifytho- 

### amount of&Pfl:lY 

### you expeCl to us-a oach da'l, 00 no! aliow m:Xed .wlutionto eland overnight

### It 

### I. 8. 

### vlo!a!!on 

# DIRECTIONS FOR USE of Fedor.1 l.aw Ie u.t thl. produot 

## In a manner Inoon,latont 

## with Rnd 

### tnUre !abo! before 

### uDlng thl. 

### product. 

## REENTRY 8TA"{EMENT 

# , 

# ,

na labo!lng,

Mb:ers, loadors- end app!lC.10f. musl WUI 

### a IvU 

### face shiojd, lOng Irousors, long 

### ,!(lOyed a.hl(l, gloves and boots to avoid., much skin nfld eye oonla.ct a8 pass ble, 

### Do not enlertr••tod noldJ wilhln 24 hOUfS altor appl'ICAlIOn unless prOiGCI!vo clothing Is worn,

# I~;~~;~,·**oo~~n.~tamlna!.** WalOf, 

### food, or toedby $!olag9 

### or

### d!sposal.

conlalnor Is broken Ofconlon!, hayti' spWtd, fo!:Ow a!i procat.liol1s lnd£atod above and clGan up immodlate!y. Bejo:o cllUlnlng ,Jp,

on full length trovsots.long sloaved shirl. pt1)!GC!Iv., gloves, and gogg'••or

### fac. ahiold. Soak up sp:U wilh absorben! med:a such und,

## eann or Other**$~** 

### hable matfYlal and dispose of waSle tI! an approvod watfe dlspollal fac:lii)'. 

# I**~!~~~:~~I~:;** DISPOSlIl**I~** ! wastos arllllOJlotf ha::ardOU$. 

### Improper dispeaal 01 flXCGli 

### pntk:-cde, 'pray mlxturo, or rln5810 !s

..

### violation of Fedora! law•

. !hesa wastos cannol bf disposed o! by 

### use according to fabol !nslruct!otHi. OOnt3Ct 

### your Stale Pestlctde or En,,:ronmental (:<)nlrol or thl 

### Hazardous Waste ropretOr'ltslNO atlho noarl)s! 

### EPA Reglonat 

### Olfjca for guldanct-.



## GENERAL INFORMATION COTTON 

### II 

### !' I 

### or and atafli!ary



### Afoliarspray of 

### PREpN t,ra:1d EthephCn

# wm acce!&raIQ

### oponlng 01 maturo Urlop&l)&d cotton boEs and onharv»da!oHatioi"l which 

### eM result In earHer haN9stwith an !ncrollsed rocovirabfQc y;okL PREPtl-I brand EH.opllon trulmenton colton aKows Increased o!fjcl(mcy from 

### a on<»..o".r h,,,,,,osl TOBACCO**(FL.UE~CUAED}:** A 

### fol,lar sprey 01 PAEPTl{ 

### brand Elhophon promotes early. uniform ')'ollowlng· of mafure !ot,acco, 

### PREp1).( r&duon curing !:IT!G, 

### allowing 

### mOl. ufficiont 

### usa of cJrinQ barn spaCQ. 

### and InctU$&d conko! O'l&r 

### harvost 'chodulu. SPRAY PREPARATION Add 1/2 to 

### 3r4 oft\;& requIred amount ot wattr

### tothO' spray !a!'\k Start aQhatlon. Add tho r.q'.lirtd aMOunt of PREpno brllf'ld Ethophon. and lhe r.malnlng: amount of walliH. Propare only as much Gpray SOlution fl'

### can 

### biJ used on tho day of mixing. Do not atlow 'pray 

### solution to stand 

### oVtrn!aht. 

### Do not spl!! tht

### conconlratQd producton',pray equIpment Of

### afrj ahplane parts, ANY SPILLS SHOVLD BE RINSED IMMEDIATELYWITH PLENTYOF WATER Use of a nutsotank Is hlOltly (Gcommondod for avoidir<9 pouibl& sp%. of COXllnltalGd for<Tlu!allon on spray oquipmon! or any alrj:·fano 

## pans. ·.MPATIBILITV EPlll: 

### brar'od Ethephon ii

### compstibio 

### wllh DfF', FOLEX3
, 

### Drop;l.

### HaNMo3•

### Mothyl Parathion. Guthion 1

, 

### and Malalhk.m4, 

### and msy be apptiod 

### in uquenceor as 11tank Mixture (00NOT TANK MIX WITH DESICCANTS !F COTTON IS TO BE SP!NDLE HARVESTED). 

### to !>oma CUG9 slight roductittl'l in bol,: op&n!ng r.upon"**hlt~** 

### baGn obsorved when lank rnbHII!I: wi!h dGfoliants were ueod. 

### Good agltaHon In the 'prf_Y tank It Gssunllal a1d til 

### tank ml:<ture should nol b. a.llowed to IIllInd wi:hout &OII9.I;on for more Ihan 5to 10 m;nutO$. Road and ob••rvo all**approprial~** 

### labal Ul!iG direc110ns Mel precau!lons for !he dolol!an!s and !nsoctlcldes usod. NOTE: Ur.dorcortaln O<tnd1lionG. lan% mixtures of PREPn; brand ElhOpr.on w:th desfocants contaIning lIodlum chlorale could r.sult in 

### !he form.!bn of hypcCh!OfOU$**ac~ds** 

### which 01'1 Maling wHl omll loxlc chlor1do fumos. EQUIPMENT CLEANI'IG &caus. o! !he acidic nat!lrG o! Ih19 product. prc-longiJo 9;O:poSU!$ 

### to spray doposltwi\) damaQe acryliC pfasl'iCS. certain paInts, and 

## meta". Atnsa !horoughly with a d"tergenl ano waler**a~!** 

### ox,POsod ac,),llc p!SSI-i:-lypo malarlals 

### (e.g., alrcrall windshields}, and paInted su(acos wlfhln an hour alter**~Xj::OBur9** 

### to splay capoal!s. At the end of .ach day, rinse thorovghly with a dotorganl and waltH atltho metal pariS of !hll 

### airel

### e.!! and tho usoc!ated spray oquipmont oxposod to the spray deposils.



# 130

# ••
.............. -· ....................**~c~(5~T~fp,()~Nr"**

# .....................................

USE



### PREp'IlI 

### Boll Openar'

PREPni 

### + 

## FOLEXc Oofollanl Tank



### Mix


### Oropp' Tank Ix**Prl~Condltlon.r** 

## for Oafonatlon 

### EXPECTED CONDITIONS



### Hot and dry OO"For 

### tlghq, 

### OJ)' and 

### 75to

### WF 1113


### 2 0:>01 but above 

### 6S"F 2 2/3


### H·gh sol!**moisl'Jr~** 

### Hgh lGinHity lovel 

### R)nk cotton


### H-go scll moisturo 

### High fortlhty lovel 

### A-lnk OO1ton

Hot, dry, 

### abo". 

### Cnot above OO·F Rttnk collon 113

113

213 

### 1113 1 113

### PFtEP'fl.! 

## RATE


# t..
2,0

0,25



### 0.25

0,5 1,0 1,0 6
4 

### 3



### 24

\2 6 6 SPRAY VOLUME 

### (OalalA)

15·50 

### 2·5

15·SO 5010



### 10·50



### 2·5 APPLICATION 

### TIMING

Apply 4 \0 7 day. pr!::H 

### defoliant. Enhanoo. crop dololla.\ion 

# rtduoin.1 dOlorlorallon of boltOm 

### and allowt for**;;"ril'~rl** 

## ·pratr.atm.nt Wllh Oolollonl. P,lor 10 PREP'" Sol! Oponlog Tr•• lm.ol If Ihe colton Is overlyfanl;or \Ilylng down In the mlddln and good spray covoreg.ofthe bol$ with PREpn.! 1$ dllficuil. a

### prG1fOalmenl**w~h dofo~anl$** 

# Vim be useful to lmprove boll coveragu with PAEpi'M, Use do-saoo rtl!&' 01 PAEPN brand Ethephon Corton Bon Openor rocommondoo for bonOpE nlng. Read and obsGrve all approprlala label USQ c;reClions and 

### procaU1ions for Iho doroliant us.ed. "In Cagiornla 

### and Arizona 

### use It

### velumi 

### of no Ius Ihan 

### 5 Oa!!ons por acre fer 

### asr:e!**app~ca'ion$c.** 

## Bolt 

## Maturity

...... bon Is 

### mature whOrl 

### fIls 100 

### hard to bl1l 

### dented \vhClO oo.'

..G-azold 

### b"lwae:'l Ih:;mb end 

### lioQors: 100 hard 

### to M 

### slicod with a

### 'ha:p knffJt, .nd 

# won the Had

### coal b&co"os Ughl brown In 

### color. 

### Use LImitations Do not oxoood a 

### maximum of2.0 lb. aliA 

### lorcomblnltd IJSGS 01 PREPTM 

### poracr&

### peryoar. 

### eoll Opening: Do nottank mix 

### PRE?n.< brand Elhephon 

### with« du!ccanllf lh9 

### cotton Is to 

### be spindl-e harvustad. Pre-Condilion for Oefollalkln: 00 

### nol tank mix PREP"« wah dulocnnts 

### unless**p~ant** 

### dGslccallon is 

### roqulred. Do 

### nol use IIde ollan! 

### bGlore thore Is sufHcioll1 

### malure liilcpened bo:ls 10 

### produco Ihe dea!rod ylfJld ($80 Gonoralln!ormation 50clion on how 10 'Ol\t for bon maturlly, WHEN TO HARVEST OOTTON 

### Dc: nol nauv"sl 

### cotton ,ooner Ihan 

### 7 days: after atreatmo"l, w!lh PREp7M brand Elhophon Cotton 80H Opener. Observe Ihe treatad 

### crop nod haNasl when optimum 

### boli opening has bMn 

### leached, Too oarly 

### harvo,1 mrghl 

### reduce Ihe 

### lull advanla99 of Ihe Iraatmenl and 

### 100 f,le 11

### harv.n·1 may resull in rOdt.cGd" qua:;ty ard foss oj Hnt which 

### wll! drop flom tho plant

## .... ,**~,=,,','IY,,-,------------"--"**



# ............ --·..----..**----------~T"CI'BeMArrC~C~O~------** 

# ...... ----------.... ------

FREprw: 

### Crop S1tuatlon PhllsfAcrl)
Directed Spray 

### Application

aver-Tho-Top Application j 

### 113

I 113

- 2 213



### USE LIMITATIONS 50·60



### 40-60

# (Flue-Cured Only}

Uso orop noulas. gpa a\ 

### 35·40 

### 2nonlospOr tho spray to 

### I 

### Specific Dlrectlooe
00 spray 

### lips dosJgnod 10 

### apply ! 

### tractor speed of 2·3 mph. sId, 

### ofthe rowdropped low enough 10 

### rIpened and harvul.d. Thorough 

### .pray

.. dlraettd spray. b, CUfe 10 harvG$\ all inavG$
Traal only when loaves fomaJnlng on Iho stalk are- maturo, To 

### Ol1sur. remaining 

### Joan. are 

## maH.ne. tosl spray sovora! tobacco plam& as 

### d8$C;I1»d undorthe 

## netlon ·Prop.,limo 01iroatmant." UiIII the lOwer rato In a normally mature crop whon exporl.nco rndk:alos Ihat mInimum rip4ning lnduooment

## r. rGqulrad. U

..tho higher rale who" tho 

### crop Is 

### hoavy aM a lende"cy 10 be mort rank or

# wh." t.mperaluroa art Iowor than normal. Always 10$1 spray 10 datormln. 

### 11 Iho tobacco 

### 1; maluro onough to respond 10 Irealmenl 

### wilh PREpnt brand Elhephor.. Apply oyor·lho·lop 

### PReJ'"fH bral'ld Ethophon spray 

### as a {L"IO 

### miSI uSing nozzles nozzl. 

### tips ovor Iho conlor of tho plant, 

### and each 

### so all are covered similar 10 the

00 "o1 apply PREprn brand Elhl}phon

### to im('rltl;\irQc leaves il$thls

### can r$$ua 

### Itt unsallstaclory coloring,

.....QIghl iO$$ 

### and reduced 

### leal quality. 00 

### nol albw Ihfi

### crop \e 

### ovor 

### ryan :n the tlc:d n!ler using PREpt>1 brand 

### EthQp-hOn, 4!nCG Ihls. may 

### cause ,omo roduclion 

### In ylold ana 

### Qualily, Do 

### nollreat bofo(e Ilntl:ipal&d ma;or slorm which could 

### piCt'lenl hat"tSI and 

### nu,ul11n crop 1:)$$, 

### Do nol apply PREpn.! b'and Elhephcn 

### If raIn 1S oxp&CtG-d 

### WIthin 4 

### hours, 

### APPLICATION TIMING Succoulul rotults. 

### with P=tEp'l"V cal! fQr Irulmanlwhen l&avGS afe mat"rq, nol oVlO'rly rank gr90!'\ 

### wha(\ sprayed, To 

### eas:\y ctl'lHmlm, tho proportr&alnWn\ 

### t1m:rg and tho "umbor

### 01 I{HlV6S 

### po: sla!k r"tldy for**hafV(J$~.** 

### t2S1 

### spray $&V$ra! p:anls in mote Inan onG 

### loca'il}!l il1 oaeh 

### field and ob$ervtlhn response. Matura l.-avos 

### wlli Mglnto 

### yoHow in 2410 

### 72 hours. Te$IIQavolllhal 

### taU 10 

### ,allow 1072

### hOlifS aro flot mature 

### and are nol 

### mad, for 

### PREpm brand Etnophon troatment. 

### Wah a fow days. 10 pormll furlh;)r nalora! malUring, tlien 

### make anolher tO$l 

### spray or**~maIUfIIY'** 

### chock. When you havo conllfmo!llhe n!lmOOf of 

### !oavos oor planllhat Wlil 

### coior, you 

### cao d$lerm::'\0 Iho nllmber 01 acros to lroal in 

### Older 10 

### f!ll 

# 4vbarn

... pan yO:"r

### t9.sl spr.y b, mIXIng one leaspoons of 

### PREpn!: In 

### 1**q~art** 

### or wal;)r. Spray each I&st planl With aboul t oz. of this m'>::turo, va

### ring allla'V"swith a'ine mitt PREpw brand Ethophon will nol color imma:uro sprayad luvlJos. 

### WHEN TO HARVEST All mal%,sprayed /GaVel!**VI~I** 

### oogin to color within 2410 72 hours allor PREpm brand Elhophon appilcsl\oft. The yoJ:OWII1Q

### ptocus is weather dopendanl; cool weatherwlU dalal', wh:!a hOI, 

### slinny**w&a~h.r** 

### can 

### eporrj \ip 

### th. p!'OCiISS, Harvuttraaled tobacco when haves have roaoh,d the do.lred color lnluns1ty. Do nol allow tobacco 10 b-lcomo CVGr rips oetoro slarling haNGS\' Lnfdrop can occurwho" tobacco Is over ripe and lalt on Iho stalk. If 

### II numboroftho boltom loavn have y&!lowod a! Iho 11m. 01 traalrr.oni, :bill' shOJld b$ htl.(vasled priorto spraying w!th PREpm brand Elhophon. Wllh an over·lho·top appliC8tion, narvGstlng can oommoi'lCo 24 

### houri. after PAEpN brand Elhephon app:lcallOn d&panding on wNtther cond,\ton$ orto avoid ova. ripe lobacco. Tobacco harveSt6:! 24 howrs IIJ:er Ireatrr:ont will require mora limgln IhQ colorIng phase 

### of Iho curl"O procoOI. 

### CURING PREP"'**TRE~TED** 

### TOBACCO 

### CorinC procedures .ro as mvch an art as II sc:anca 

### ancl each CJ'/}**n~u~:** 

### bo jJdg&d 0;) Ih!) basis 01 :obaoco condiliofl, Inlerval b01Wten IrealmfJf\l and 

### harve'l, wnlhu( am;! typo of eUl,og facility batOrt prosClipHon lempOra!uro and ltonUiatlon schedulos Ci'/fl bg G$tab'lshed. 1'0 ob1aln mlxlmum c,.uaMy, c&.tO musl bs tak&1'l \0 obt.GNa and oonlrol Iho cudn-g Pl0COS$ clOS$1y, (lspeolany dtJtlrg Ifle lato ·colorlno" and early ·crying'"slag&o or Iho loa!, F'A.EPN brand Ethephon trealed tobacco wLl ha

....el!ilartl;ld Iho colOring prOCQSS wf1&n harYo$led, rO'duo:ng Iho timo requirod In ths coloring phato 0{

### cwll'lg. rreated tobacco should ha drlad IMtor. !ftobaooo tnyu ar.gre." OfO?nlail'l lome grGon when hlltll.V,

.. 

### d. It 

### may b. necsssaty 10ool::n Ihom for afaw hoUfS, IllhatOlvlIIS are oomp!ol.oly

### yoV-ow, IOfl\jXlratvTo and vantllalion musfb. adjuslad in a mannor 10 drytho lobac«:l !islasl U 

### f»$$lblo v;iln-:l'ul :tea!dlng, One&"**~ho** 

### Ibaf 

### Itdried (3/4 

### dry}, you .hooklloUcw normal proo.our•• for

### C\t(mg. Slt\OG: 

### PREPfM brand Elhapnon Ir&aloO !&a"1)& curo 1il$I&r, 1roaled end unlroalod loavo$ shoutd nol bo curod logolher In tho aamobarn, 

# 132.' 

## , 

# LIMITED WARRANTY AND DISCLAIMER Tho rnanulaotwl}t watra'Is\3.) 

### that this product oontorms 10 tho**ch~mlca!** 

### dei-CflpUon on tho- lilbGI; 

### {b} thal this prodtJct Is rouollably lit lor tho P.Jrp<)UlS 401 forth in tho directions lor U$& when 

### It III usod In accordance Wiih elJch direction.; and (e) thaI tho -dlr(!e{lona. warnlng and o:bot statemonts on Ihis lab!)! at. basad upon riuponslbfo exports' evaluation of 

### rusonable tosls of of!octiYonoss, 01 to:t:icity to labora:ory animals and to plants, and of rosiduu on food crops and upon reports olliold 

### oxporlonct. Ta$ta hall. not boan 

### made on al\ '1imMles or h all slatuor ur,dor 

### all cond!\IOrIs, THE MANUFACTURER NEITHER MAKES NOR INTENDS, 

### NOR DOES IT AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE, ANY OTHER WARRANTIES, EXPRESS OR IMPLleo, AND IT EXPRESSLY EXCLUDE:, AND DISCLA!MS ALL !MPUED WARRANTIES OF**t~RCHANT·ABIUTY** 

### OR FITNESS FORA PARTICUlAR PURPOSE. THIS WARRANTY OOE:, NOT EXTEND TO. AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR. ANY AND ALL LOSS OR DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENr WITH THE

..ABEL DIRECTIONS. WARNINGS OR CAUTiONS. BUYER'S EXCLUSIVE FIEMEDY ANO MANUFACTt!AER'S OR SELLER.'S EXCLUSIVE L1ASILITY FOR ANY 

### AND ALL CLAIMS, LOSSES, DAMAGES, OF,INJUR'ES RESULTING FROMTHE USE OR HANOLINGOF THIS PRODUCT, WHETHEROR NOT IlASED IN CONTRACT, NEGUGEN)E, STRICT UABIUTY IN TORTOR OTHERWISE SHALL BE LIMITED, AT THE MANUFACTURER'S OPTiON, TO REPLACeMENTOF. ORTHE REPAYMENT OF THE PURCHASE PRice FOR. THE QUANTITY OF PRODUCTWITH RESPECTTO WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL. INDIRE')T OR "'...oNSEOUENTtAL

# ct,

### \!1GES RESULTING FROM THE USE OR HANDUNG OF THIS PAODUCT NonCE TO BUYER Purcha'1'. 01 thi$ pro&Jcl dotls 1'01 COllfGr Emy rig'll!> und'l! pa:icntll gov&rnir,g lh:s product ortho 1J5Q II1&r&o1 In CO,I/'l!t;ac 

### ouald. 01 tho Ur,il&d Slalos



### _ F.F and Gulhkm BIO 

### rD\I,t1(Hoj traOQm8lk$ 01 Bayor 

### AG, 

### Oormany, fCPP 

### Is 

### a r&gislored 

### Ira(iemark 01 

### NOR·AM Cn&mlcal Company, 

### !l.Harvad9 it

### a r.;;rstnrGd ti<ldomark 01 

### Un:royal Company, 4Ma!alhion 110 6 Iradoma'x. o! MerICa:! Cylinamid Company,



# •

Rh6ne,?oI.;IQn¢

### AQ Company 

### P,O. Box 

### 12014, 2T.W, Aloxandar DrivG Rosearch**TdanG~.** Park, N:lrth 

### Caro:lna 27709 PREP 15 InO :ra4omar'1\ 01 Hh6no·Poulonc lor EthGphon C:;r.C11 Boil**Opor~r** FOlEX is a rogistoroo Iradomark 01**Fl~Mo,Po\Jw.nc** 

### PREpl'>! brand Elhophon for Cotton an<:! Tobaoro 

### (PENDlNO) Resuomltted 

### 1217/92,

## ------------'-'--

- -



## Mr. Warren A. Davis Rhone-poulenc Ag 

## company P.O. Box 12014, 2 T.W. Alexander Drive 

## Research Triangle park, Ne 27709 Dear Mr. Davis: Subject: Add Use on Tobacco 

## PREP Ethephon cotton Boll opener EPA Registration No. 264-418 Your Submission Dated october 26, 1992 prior to approval of the new use, you must comply with Title 40 Code of Federal Regulations Part 152 subpart E - Procedures to Ensure Protection of Data Submitter1s Rights by 

## choosing either the Cite-Allor Selective Method of Support. Please note that under the Selective Method for this product, you must submit a Data Listing of all 

## product specific and generic data required 

## by 40 

## ern 

## Part 158 since this product does not qualify for the formulator's exemption. For each data**require~ent,** 

## you must submit or cite an appropriate study or document that a data gap exists. We have no adverse comment on alternate brand name and the revised labeling except the Environmental Hazards statement should be updated to inctude the following statement: Do not apply directly to water, to areas where surface water is present or to intertidal areas below the mean high water mark. We are holding the labeling in our files for this product awaiting "resolution of the above issue. Sincerely yours,

# 0v,"~ \J Cynthia Giles-Parker Product Manager (22) Fungicide-Herbicide Branch Registration Division (H7505C)



# 134

# /' 

# "'PRE pm BRAND ETHEPHON FOR COTTON AND TOBACCO
For Commercial 

# Use Or Agricultural Usa Only. Not For 

# Residential Use ACTIVE INGREDIENT: Elhephon (2'(;hloroelhyl) phosphonic acid' """,

.."

.."

..""""""""""""""""""

..,55.4% INERT INGREDIENTS:

............,......,."

..............""

........,......,.........,,,..,..,..,"

...""

.................,"""""",,,

..

### .44.6% 

### -This 

### product contains 6 pounds ethephon pergaJlon. EPA Reg. No. 264·418 EPA Est. No. 264.PA.Q1 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO
PRECAUCION

### AtUSUARIO: SI usled no loG 

### ingles. no use otto producto hasts quo 18 informacion en 

### Ia Gliquota Ie 

### haya sido olCplk:ado

I' uses are U.S. ,188

# and,-.:ii.4Ci,ih9: license 

### is granted 

### to use this product In countries other than tho Offor any

• uso not contemplated by this I liability tOf patont inlrlngoment may rosult from use or sale 

### of this product outside tho United 

### Stales. 

# STATEMENT OF PRACTICAL TREATMENT IF IN EYES: Hold eyelids open and flush with a gentle stream 01 water lor alleast 15 minutes. Gol medical aHontion, preferably an ophthalmologist. IFON SKIN: Immodiately wash skin 

### with plenty

### of soap and water, Remove oontaminated clath'Lng and shoos. Wash cloth'Lng $Gparato'y before rOUM, IF SWALLOWED: 00not induCe vomiting. Promptly drinka largo quantity of milk, 

### egg whitGS, golatin solution or 

### ifthose are nol available, drink large quantities. ofwator, Avoid alcohol. Can a phys;ician immediately, ,/ IF 

### INHALED: Remove victim to fresh air. 

### Hnot breathing, give artificial respiration, Administer oxygon 

### If nocossary. Gel me<iical aftention, 

# PRECAUTIONARY STATEMENTS DANGER HAZARDS TO HUMANS AND DOMESTIC ANIMALS

• CORROSIVE. Causes fileaod skindamage. May

### befatal 

### it absorbed through skin, Harmlul ij swallowed or inhalad. Avoid broathing spray mist. 

### Do not get in eyes, onskin oronclothing, Woar luillongth trousers, 

### long sleovod shirt, protoctivo glovos, and goggles or faco shieldwhon handling, Change 

### to clean workdOlhes:daily. Wash thoroughly with soap and water altar handling and bGfOl'O oating, orsmoking. Romovo aod wash cootaminatGd clothing bGloro rouso. Kaop away lrom domostic animals. 

### NOTE TO PHYSICIAN There 

### Is no 

### $p(tcific antidote. Alilraatment should be based on obsorvGd signs and symptoms ofdistross inthe patient. Overexposure to materials otherthan this product may have occurred. Victims ofsovere overexposuro, by inhalation, should 

### be kGpt under

### medical obsorvation lorupto 72 hoursfor delayed onset 01 pulmonary edema. In a victim 

### ofover-oxposure 

### by logGttion. C8ralul gastric lavage 

### is required duetothe possi4Jlity 

### qI stomach or esophageal perforation. this material is an acid. but usa01 alkaline subSfaocos to neulralize 

### it iscontraindicat!ft.···· 

## •••• ENVIRONMENTAL HAZARDS •••••• •••••• De notapply diredlytowater orwetlands (swamps, bogs, marshes, and potholes). 

### Do not cootamw,ata'lMterwhen Qiaposing of equipment washwaters. • • ••• 

## •••••• ••• Do not contaminate water us&d for irrigation ordomosticpUI'JX)S8$< :: ••• 

## USE PRECAUTIONS 

## •• •••• •• •••

## •• 

## •• 

## • • Do notapply PREpm brand Ethophon Cotton Boll OponDr through anytypo of irrigation systDm. ..:••• Avoid spray drift

### to nearby crops as this prodOCl will cause modifications in plant growth, Plant injury or

## reducoJ"(i,~iII rosult 

### •

Do not plant another crop within 30 days after treatment. •• • 

### •• • Mix only tho amount ofspray you expect to useeacllday_ 

### Do not allow mixod solution to stand overnight. ••• 

# 135

# .- DIRECTIONS FOR USE It ,. 

### a violation 01 Fedor.' law 

### to use this product In a mannor Inconal.tenl with Its 

### labeling. 

### R.ad entire labol before using thl. product. 

## REENTRY STATEMENT Mixers. loedeNS and applicators must WON a

### fuU laco shiold. long trousers, 

### long s\ooved shirt, glovGS and boots to avoid as much skin 

### and eyo contact as possiblo. Do not entertremed fieldswithin 24 hours afterapplicaHon unless protoctivo clothing is worn.

contamlnato water, food. orfoed by storage ordisposal. contain.,. is broken orcontents have spilled. 

### follow all precautions Indicated 

### abow and clean up 

### immediately. BGfO(G cleanIng up,

on luU trouhrs, long sloovod shirt. 

### pro1oc1ive gloves, and goggles or lace shield. Soak up spill with 

### absorbent media such

# I'**~!~!~;~** Ot 

### other suitablo material anddispose

### ofwaste at an 

### approved wasla disposalfaclUty. DISPOSAL 

### wastes are acutely hazardous. Improperdisposal of 

### excess peslicklo. spray mixture. or rlnsata is 

### a violation of Fooarallaw. 

### wast.,cannot be 

### disposed 01 by 

### us.according 

### to label instructions. COfIIact

### yourState PasUcido or EnlJironmental Control

### I~~;~,~~,~"':~eHaurdous.Wasle representative at the neatost EPA Regional OIfico lorguidance.**i~** 

### DISPOSAL the empty containers. Then offor lor 01 

### in asanitary


## GENERAL INFORMATION COTTON A

### folIarspray

### 01 PREPN brand Ethephon wid 

### accelerate openIng 01 

### matute unopGnod corton bolls and onhance defoliation which 

### cat! result 

### In earlier hruveat with an 

### meteasod tecoverable yield. PAEpfM btand Ethephon trealmont on cotton allows 

### increaaed efficion<:y 

### lrom 

### a once-over harvest, ) 

### TOBACCO**(FLUE~CURED):** 

### A loliar spray 01 

### PREpm btand Ethephon ptomotes. early, unifotm "'yellowing" 01 

### matute tobacco, PAEPTN reducos curing time, allowing mote efflc:lont use 01 

### curing batn space, and increased control over haNGStschedulos. SPRAY PREPARATION 

### Add 112to 

### 3t4of

### tho tequired amount of

### waterto tho spray tank. 

### Start agitation. Add tho required amount

### 01 PREPTM 

### brand Ethophon, and thG temainlng amount of

### water. Prepare 

### only as 

### much spray solution as can be

### used 00 

### tho day of mixing, 

### Do not allow 

### spray sotu1ktn to stand 

### overnight Do not spill the conoentral:od product

### on 

### spray equipment, or MY 

### airplane parts. 

# mv SPUS SHOULD BE RINSED IMMEDfATELYWITH PLENTY OFWAl'ER Use 01 

### a nurso tank is highly tecommended fat avoiding possible spill$, 01 

### concentraled lormulation on spray equipment at any airplane



### • part,. 

### COMPATIBILITY PREPTW 

### brand Ethephon ia compatibto with 

### DEF1, FOlEX-,

## DreW. Harvadr·Methyl Parathion, Guthion1, 

### and Malathion", and may be 

### applied In sequenceoras atank 

### mixtute (DO NOTTANKMIXWITH DESICCANTS F COTTON IS TO BE SPINDLE HARVESTED). In 

### somo cases 

### slight reduction 

### in boll opening response 

### haa bGon observed

### when tank mixes 

### with dofoliants were used. Good 

### agitetion In tho spray tank Is 

### essential and a tank mixture should_not bo allowod 

### to stand without agitalion lormore than 5to to minutes. Read and 

### observe all apptOprmto labal use dirod:ions and pl"GCautions lorthe defollents and insocticidos used. NOTE: UndGl 

### certain conditions,tank mixturos 01 

### PAEpTII brand 

### Ethophon with desiccants containilY,J sodium chlotate could result In the formation 01 

### hypochlorous acids which on heatingwill emit toxic

### ehlorido lumes. 

## • • EQUIPMENT CLEANING : ••••• 

### Because 01 

### the acidic nature 01 

### thIs product, prolonged oxposute to spray deposit will damage acrylic plastics, 

### Cftr;fl.Lr\palnts, and motals. •••••• • ••••• Rinse thorougho/ with a detergent and water all oxposed 

### &c1y1k: plastic-typo materials (e.9.• aircraf(:wln(jsi!ields), ami painted surlacos within an hour after exposute to spray deposits. • • ••• 

### •••••• 

## ••• At

### the end of

### .ach day. rinse thorougho/ with a dotergont and water all the metal parts 01 

### tho airCl).ft 4nd 

### thtl aslCCiatod spray equipment exposed to the spray deposits. •• •••• : 

### ••••• 

## •• • • 

## •• • 

### ••••• 

# · 

# .. •• 

## •



## •••• 

# .. . . , 

# . · .. 136

# COTTON

EXPECTED PREpni

## ,~~~ SPRA.Y VOLUME APPLICATION 

### USE CONDITIONS 

### RATE (Gata/A) 

### TIMING 

### 'R_E_'**.~** 

# ILBS A.I. 

# •• Air" 

### PREpm Hot and dl)' 8O"For 

### 1113 1.0 6 

### Apply when 

### th. number of 

### Boll Opener- hlghor maluro unoponed bolls Is 01)' and75 

### to**8O~F** 

### 2 1.5 4 15·50 

### 2-5 suWel.nl 10 produce the desired 

### crop. See belowfor Coolbutabove**65~F** 

### 2213 2.0 3 tast 

### of boll maturity. 

### Treatmont uniformly opens 

### 2213 2.0 3 

### boUs 710 14day.s 08111&1'. 

### PREp-rw + 

### High ooil moisture 

### 113 025 2. 15·50 5
r 

### 10 Apply .4 10 7 daY$

...**~,to** 

## FOLEX· PAEpnt boll High lertllity level

### appl~'on. 

### To be

# us.d:" Detolla"1 Tank Rank colton 

### Mix a sequential treatment with. not

### I~**-pl~of** PREPntboll 

### PREplll. Dropp2 High soli moisture 

### 113 0.25 

### 2. 10 rSO 3 ·10 

### Apply 

### 4. to 

### 7 days**PljO~"~** 

### Defoliant Tank High lorti!ity 10Yoi 

### PREpnI boll opening To be used as 

### MIx Rank colton I

# ~Ol**i~**

# pl;**;.~;~:,.** 

# w:i


# , Pr.·Condltloner Hot, dlY. 

### 213 0.5 

### 12 Apply 4 to 7 days prior to 

### lor Oolollatlon 

### Cool, above 65°F 

### 1113 1.0 6 

### 15·50 2-5 defoliant,**._~~~** 

# I**~'~P_,** I , Rank cotton 

### 1113 1.0 6 

# I**~nd** allow.of

# I':'O~.~I;: ·Pretreatment With Defoliants Prior to PREpnt Boll Opening Treatment If tho cotton isoverly rank or 

### laying down 

### in Ihe mlddlosand good spf'ay coverage. of

### thebollswith PREP"m 

### Is difficult. a pretreatment with defoliants

### will beusefulto itnprove 

### boNcoverage with PREP'fM. 

### 'Use dosage rates of PREpTM 

### brand 

### Ethephon Cotton 

### BoU Opener recommended lor boll opening. Road and observe 

### aU appropriate labal use direction; 

### and iXocautions for the defoliant used. ""In 

### California and Arizona use 

### avolume of no less than 

### 5 gallons

### per acre for aerial applications

.

• Boll 

### Maturity

.. A

### boll is mature 

### when 

### it is

### too hard to

### beOentod when squeezed between thumb and fiogers, too hard 

### to be sliced 

### with asharp knife. and when 

### the seed

### coat bocomO$ 

### Ilght brown in cobr. 

### Use Limitations 00

### nOt oxcoed it maximum of2.0 lb.-aliAfor combined uses at PAEptii per acre peryear. 

### BoH Opening: 

### Do nottank mix 

### PREpnI! t)(and Ethepoon with a desiccant iftho cotton 

### is to btlspindle harvestod. Pre-eondition for Oofoliation; 

### 00

### not tank mix PREpTW with desiccants unloss plant desiccation Is required. 

### Do not use a defoliant 

### before there is sufflclont mature unopened 

### bolls to 

### produce the desired yield (soo Genarallnformation section on 

### how

### to tost for

### boD maturity. : •••:. WHEN TO HARVEST COTTON 

### 00 nol harvest cotton soonerthan 

### 7days aftora tlOatment with PREpm brand Ethophon Cottoo**8Q{'~er,** 

## • •• ••••• • 

## •

•••• Observe the treated 

### crop and harvest when optimum 

### boll opening has been roached. 

### Too .arty hli(VQl rtllght reduct!the full advantage oftne treatment 

### andtoo late 

### a harvost may result 

### h reduced quality and bssoflinl which will drop

## !rp1"l1flJl piant·. •• 

## •• ••• 

## • •

•• ••••• 

## • • • 

## • ••••• ••• • • 

### •



## •• 

## • • •• •• 

## •

•••• •• • 

### •• • 

## • •• 

# 137PAEpnc Crop Situation PlntalAcr.
Directed Spray Application

Over-The-Top Applicalion 

### ItI3

1113-2213

USE LIMITATIONS 

### 50-60

40-60 

# TOBACCO (Flue-Cured Only)

Spoclflc Direction_
Us. drop nozzlos. Chooso TG or OC 

### spray tips designed 

### to apply 50

- 60 

### 35-40 psi and at 1ractor spoed 

### of 2-3 mph. Use 

### row; ana on each sideofthe

## row dropped low onough to direct the 

### lHves to 

### be rip4tned and harvostltd. 

### Thorough spray essontial With 

### a directed spray. 

### be sure to harvest 

### aU Ioav"
Trea1 only whon loaves remaining on Ihe stalk are malure. To remaining leavos aro mature, tosl spray soveral lobacco planls ducribod undor Ihe s&ction '"ProperTime ofTreatment· Use the Iowot in a normally malure 

### cropwhen experience ind)catos thai minimum

# """'19**i~ment** is required. Use the higher ra1e whon the crop 

### is heavy and hu a lendency to 

### be mote rank or when temperalurcts are 

### Iow.r Ihan 

### normal. Always 1051 spray to dolonnine if tho lobacco is maluro enough 10 respond 10troatment with PAEpNbrand Elhephon. Appfy over-tha-top

# PAEp1lA,~~~~~~:~!: nozzles (one nonletips so alt leaves aro

### co.\'.~'>d 

### as a fine mist using Ihree

, and each side) Iho I 01



### Do not apply PREpn. brand Elhaphon to immaturalaavos as Ihis can 18!mlt in unsatisfactory coJoring, weight loss and reduced luaf quality. Do notallow thecropto ovor ripen in Iho field afler using PRE?ni brand Ethophon, since this maycause some reduction 

### In yktld and quality. 00 notlreat boforo anticipatlKl majorstorm which could preWJnt harvest and rosult in crop loss. / 

### 00not apply PREprw brand Ethophon 

### if rain is

### OXpoc1odwithin 

### 4 hours. ' APPLICA

### nON TIMING Suceessful rosults with PAEPl10l call lortreatment when leavas are mature, nol overly rank green when SPfayed. To e.sUy determine Iho properlroalment tlmlng and tho numborof leavos 

### per stalk ready,lor harvost. lest spray several plants in mare Ihan on. location in each rlOkI and ob$OlVGtho response. Matl.>l'eloavos will begin Io-yollow in 2410 72 hours.. Tesllo.aVfJs Ihatfaito yellow 

### in 72 hours aro nol mature and are not ready lor PAEpm brand Elhophon troalmen\. Wait 

### a tew days to permit turthel nalural maluring, thon mako anothertost spray or '"maturity'" check.

• Whon you have confirmed the number of loaves per plant thai witl COlol, you 

### can delormine Ihe number of acreS to Ireat in order 10 flit Iho bam. ' Propere yourlesl spray by mixing one leaspoons of PREP'DI1n t quart ofwaler, Spray each lost plantwith about t oz. 01 this mixture, covering aU leaves with afino mist.**PAE~** brand Ethephon will not color Immalure sprayed leavos. 

### WHEN TO HAIIVEST

. AU mahJre, sprayed loav

..wlH begin to cobrwithin 24 to 72 hours after PREP'"' brand Elhophon application. The yellowing process Is wealherdepondenl; coolweathorwill delay. while hoc, sunnyweathercan spood upthe 

### process. Harvest Ireatedtobacco when leaves havo roached the desired color Inlenslty. 00 not allowtobaoco to become over ripe boloro slarting harvos!. leafdrop can occur when tobacco is over ripaJ arntloh on the stalk. If a numberof the bottom loaves have yellowed al the time 01 trealment, Ihey should 

### be harvested prior 10 spraYli'l"Wiino PREP"" brand Ethephon. • ••• With an over-Ihe-top appIlcatlon. harvesting can commence 24 hours after PRE?ni brand**Ethephop~tion** tli9tQiJing on woalhar conditions orto avoid ovor ripo lobacco. Tobacco harvested 24 houm after lreatmenl will require mtlre 

## UmSt In Ihe coprlng phase 01 tho cunng process. • • ••• 

### CORING PREpn! TREATED TOBACCO ••:

..: : •••• Curing proc:odur

..

### are as much an art 

### as a

### science and each 

### cur. must

### bejudgod on Ihe basis of**~** conQitian, lolerval betweon Jreatment and harvest, woather and type of curing lacUity before proscription temperature JpQ.'iOnliia1ion d\:IOIduJes can bo established. To obtain maximum quality, 

### ca.ro mustbetaken to observo and oonlrollho curing 

### Proctss**~ely,** e!lQOCiaily during the lale ·coloting· and early '"drying- $tage.of Ihe loaf. ••••- ••• PAEpnt brand Ethophon treated 

### tobGCCO wilt have started tho 

### coloring process when 

### harvostod, reducing Ihe liml.rlqtil1ed in tho coloring

### phase of ClIfing. Treated 

### tobacx:o should bedriedfaslor. If

### tobacco loaves are gr

.. n or contain somo gt,Mn

### whon halveslGd. 

### it may 

### be neoosaary

### to

### colofthom tor afow hours. If Iho loaves 

### arecomplelely yellow. tempora1ure and vontilatk¢! 

### rfllIIfbe adjusted in 

### a mannor10 drythetobaccoas fast as possiblo 

### without scalding, Once Iho loaf is driod (3/4 dry), you should follow norma! procodur85 for curing. Since PREpn! brand Elhephon treated Ioavos curefaster,lroatGd and untreatod leaves shorJd nol be curod together 

### In the samobam. 

# 138

# I

•.' LIMITED WARRANTY AND DISCLAIMER**~:h.** manufactorerwarranls (a) IhaNh!, product conforms to tho chemical descrlptlon onthGlabel; (b) that this product is r9a$Onably fit 'for the purposes sot fonh In tho dirOCCions for US8 whon it is used in accordance with such directions; and (el Ihat the dirGCtions, waming and O1l1or $1.atomonts on this 

### label are based upon responsible oxperts' evaluation of reasonable tests 

### of offDCtiven&ss, of toxicity to laboratory animals and to plants, and 

### of residues on food crops and upon reports of field exp4llienco. Tests havo not been made on 

### aU varierie4 or in

### all state.or undor

### aI conditions. 

### THE MANUFACTURER NEITHER MAKES NOR INTENDS. NOR DOES IT AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES. EXPRESS OR IMPLIED. AND IT 

### EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIEDWARRANTlES OF MERCHANT·ABILITYOR FITNESS FORAPARTCULAR 

### PURPOSE. THIS WARRANTY DOES NOT EXTEND TO. AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOA. ANY AND 

### AU lOSS OR DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT INANY MANNER WHICH IS INCONSISTENTWITH THE LABEL DIRECTIONS, WARNINGS ORCAUTIONS. BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SEllER'S EXCLUSIVE LIABILITY FOR ANY AND All CLAIMS, LOSSES, DAMAGES, OR INJURIES RESUlTING FROM THE USE OR HANOLfNGOF THIS PROOLfCT, WHETHER ORNOTBASED IN CONTRACT. NEGLIGENCE, STRICT LfABlLITY IN TORTOROTHERWISE SHALL BE LIMITED. ATTHE MANUFAcruRER'S OPTION, TO REPlACEMENTOF.ORTHE REPAYMENTOF THE PURCHASE PRICE FOR. TIlE OUANTlTYOF PROOUCTWITH RESPECTTO WHICH DAMAGES ARE CLAIMED. IN NO EVENTSHALl MANUFACTURER OR SEllER BE LIABLE FOR SPECIAL, INDIRECT OR CONSEOUENTlAL DAMAGES RESUlTING FROMTHE USEOR HANDliNGOFTHIS PRODUCT. NOTICE TO BUYER Purchase 

### ofthis 

### product doe!! oot confer any rights under patients governing this product ortho use Ihoroof In countrios outsido of th. United States. 

# e 'DEF and Guthion aro registered trademarks 

### of BayerAG, Germany. 

### lOropp is a rogistoredtradornaik 

### of 

### NOA·AM Chemical Company. 3HaIVado Is a registered tradomark 01 Uniroyal Company.



# • 'Malalhion Is 

### a trademark of American Cyanamid Company

.



### RMno-Poulenc Ag 

### Company P.O, Box 

### 12014. 2T.W. Alexander Drive Rea&aroh Triangle Pari<. North Carolina 

### 2n09 PAEP Is tho trademarkof

### RMn&-PouJoncfor Ethophon Cotton Boll**~nor** 

### fOLEX is 

### a registered trademark of 

### Rh6no·Poulonc

. PAEpN brand Ethaphon for CoHoo and Tobacco (PENDING) Submfttod t0I23192. 

# . ...."



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# (;It RHOfIJE-POULEflJC**,~** , #



# • RHONE·POULENC AG COMPANY



### Onobef 25, 190)
U S EnvlfOfo!'(":n!.;t\ 

### P:-,jt<:" ;tE,n p,';Ie'":r;:: orfice 

### of P,;s

### t!(**;(!~,** Pr')(J{ ;:rn C'(XUITlem**()r0i~E'~,3l!** :,) Desf.(**P00n~** 

### 26(1 ,':c..,**.:::rys~,)l n~jl** **,~~~'.** 

### 2 1921 

### Jeff,,[ SDfl i),-.r,':":; Hl';i\"iN;lj 

### A.rlington, \J\! 

## glr.ia 22?0) 

### Attentlon: 

### Cynthla Glles-Parker 

## PI oduct rc.anager (27.1 FungicIde HerbKiof Gra::til**R~gjstr0UQ!'** 

### Oi'/;s)')n (!ITj0':"lC)



### -,tie- 

### apprc<li.iti: i !;,,'2:-./;n9 / 

### )U; ,)(teJ)t':r.c;;- ",: 

### tl**I~~** I'Z:D,:'1 rJ<;tiO'd 

### Octi)bf( 20 1992 The**cr~angfS** Le.< LCj.;- [(lVl;'!J;-·n',.:l)lZ!l**H~'2~:r{j S;:!.:t~{)::** **o~** til(: 1';:b:::l**ila'~'(·** b(;'O'n rC,)(jc, "nd as f0(juested 

### (we copies. '')( trlf

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### ! :!l'0; i,19 ;

### '!**a;~(',::r,.JNJ** : 0,' \/O'_x I""c::;rc;-"



### Sincerely, 

# •
'flarr£:'n p."**D,Jvl~.** SenlOr Reiji<:,t!**.)~** 10::**l'1;::ncl~;':1**

i'\:g(;/**',J)'~** ? i i•
.**~L~\;8L** "" ;:,(, ·/oe**iP;;s'_~r,':;rl** TRA_'iCo\ C**".~Wi'** :,)l. 2,':'_,-,**:,j"~;):'\(!** /ifJ il<lR',,qF)h'",( TLI.UtJ'JflBC'-l·ly;:!r,; .\i;:'-i,' -·1-,,'.(; /, '. ,'\' iNrrfiNN,VV ••**DSF1l'UiQ!',Sf'(W'i~L**<**h~, ',I~e+H**  I't))-.' ;,j,_, 

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### • •



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## • • 

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# ., 

# ETHEPHON COTTON BOll OPENER For Commercial Use Or Agricultural Use Only. Not For Residential Use ACTIVE INGREDIENT: Ethephon**(2~Chloroethyl)** 

### phosphonic acid-

.............................................."

.......**,.55.4~/"** 

### INERT INGREDIENTS:

.......................................................................................................................... .44.6% 

### ·This product contains 6 pounds elhephon pergallon, EPA Reg. No. 264·418 EPA Esi. No. 264·PA·01 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO
PRECAUCION AL USUARIO: 51 usted no 100 Ingles, no use 0$1(1 produclo hasla que Ie Informacion on la otlquete Ie haye sido DxpUcado

Tho 

### Use 01 this product lor a varlGty 01 plant growth regulation USGS is covorod by United States and loreign patents including U.S. Patents 3,879.188 and 4,240.819. No license is granted to use this product 

### in countrios otherthan tho United Stales orfor any use not contemplated 

### by this label. liability lor pattlnl infringement may rusutt from use or sale 01 this product oulside the United Statos. 

# STATEMENT OF PRACTICAL TREATMENT 

# a IN eVES: Hold eyelids open and flush with a gentle stream 01 water for at least 15 minutes. Get medical attention. preferably an ophthalmologist. IF ON SKIN: Immediately wash skin with plenty 01 soap and water. Remove contaminated clothing and shoes. Wash clothing separatoly bolore reuso. IF SWALLOWED: Do not Induco Vomiting. Promptly -drink a largo quantity 01 milk, 

### egg whites, gelatin solution or 

### if those are not avallab1o. drink largo quantities ofwater. Avoid alcohol. Cal! a physician immediately. IF INHALED: Remove victim to Iresh air. II not broathing, give artificial respiration. Administer oxygen if necessary. Get medical attention. 

# PRECAUTIONARY STATEMENTS DANGER HAZARDS TO HUMANS AND DOMESTIC ANIMALS CORROSIVE. Causes eye and skin damage. May 

### bo latal if absorbed through skin. Harmlul if swallowed or inhaled. Avoid breathing spray mist 

### Do not get'ln eyos, on sk'ln Ofon clothing. Woar lull lenglh trousers, 

### long slGOved shirl, protective gloves. and 

# E gIO$ orfac.shield whon handling. Change to clean 

### work clothes daily. Wash thoroughly with soap and water after handling and 3toro eating, orsmoking. Remove and wash contaminated clothing bolore reus•. Koop away Irom domestic animals. OTe TO PHYSICIAN Thera 

### is no specific antidote. All trealment should be based on observed signs and symptoms 01 distress in tho Pillen!. Overexposure to materials otherthan this 

### product may have occurred. : ••••• Victims of severo ovorexposure, by inhalation, should be kept under modical observation lor up to 72 hours wr d.layed**oos·~·~** pulmonary edema. In a victim of overexposure by IngesHon, careful gastric lavage is required due to tho 

### poslibMy 1:If**sto~ach** 

### oJ esophageal perforation. This material is an acid, but usn01 alkaline subslancGs 10 neutralizo it is contraindicated.. ••: ••: 

## " , 

## ENVIRONMENTAL HAZARDS ':' ":", Do not apply diractlyto water, to areas where surfllC1l water is present or to inhn1idal areas bolow the mean h'lgh wtlMromark:bO·not contaminate water when disposing 01 equipment washwatefS. ..:. • Do not contaminate water usGd lor irrigation or domestic purposes. 

## USE PRECAU110NS 

## , 

# " " 

## ,

•••• Do not apply PREpm brand Ethophon Cotton Boll Openerthrough any typo 

### of irrigation system. :.. •• 

### , 

# .. •••••• 

## , ,



## " •••••• 

## , , ••••
Avoid spray drift to nearby crops as this product

### will cause modilications in plant growth. Plant injury or roouced yieldswi!! result. 

### Do not plant aoothsrcropwithin 30days altor treatment. Mix only the amount 01 sprayyou expoct to use each day. Do not allow mixod solution to stand overnight. 

### HOT RE;vIEIlED In**Ar:r;01~{lanC0** 

### utth PR Notice 82-2, i? ') S('i) ,')':; 

### i')'«cft Leoeling Dated ,£"'**/;,,:,~** " / 

# 141

# DIRECTIONS FOR USE It Is a violation of Fedoral law to use this product In a mannor Inconslstenf with Ita labeling. 

### Road entire label bofor. using this product. 

## REENTRY STATEMENT Mixers, loaders and applicators must wear a lull faco shield. 

### long trousers, long sleovod shirt, glovo:!! and boots to avoid as much skin 

### and oyo contact as possible. 

### Do not enterfreatod 1i4ldswithin 24 hours aher application unlos:!! protGCtive clothing Is worn.

not

### confaminate walsr, food, 

### orfood by storage ordisposal, container Is broken or contenls havo spilled, follow aU procuutions indicated above and clean 

### up immediatoly. Before cloaning 

### fuiliangth trousers, long sleeved shirt. protective glov05. and goggles or face shield. Soak up 

### spm with absorbent modia sand, earth or other suitable material and dispose 01 waste at an approved waste disposal facility.

# I~:~~J~~I~:!, 

# DISPOSAL I**~** wasles aro acutely hazardous. Impropordisposal 01 QX¢O$$ pesticide, spray mixture, or rinsate is a violation of Fodorall thole wasfes 

## cannot be disposed 01 by use accordill9 to labol instructions, contact your Stato Posticide or Environmental

# Co"',,,11 Waste reprosontative af tho noarest EPA Regional Qfljce for guidanco.
Then oUor lor


## GENERAL INFORMATION 

# "' 

# , ."dd

## d;:p<"_~ <01 in a '"','•

# ..,1

A foUar spray of PREpN brand Ethephon Colton BoU Opener 

### will accelerate opening of mature unopenC'fd colton bolls and enhance dofoHaUon which can rosult in oanior harvest wtlh an Increased recoverable ylold. PREPTlo!. brand Ethephon Collon Boll Opener treatment·allows iocroased offlcllitflC)' from a once.over harvest. Somo premature drop ofsmall, Immature bolls may be associated with treatment. 00not apply boloro sufficient, maluro, unoponod bolls have dcweloped to produce Ihe dosirod yiold 01 colton. Aboll 

### is mature whon It 

### is 100 hard to be dented whon squ&ozed betwaon thumb and IlngofS, too hard

### to be sliced with asharp knife, and whon the $Oed 

### coat b«:om05 light brown in color. For 

### best rosults, thorough and uniform spray coverage Is required. k is essential that fho bolls are contactGd by the spray 

### to obtain optimum boll oponing. Ohsorve treated fields closely. HalVost at optimum 

# boa oponing and dofollatlon, gonerally t4 to 2t days aftor troatment. Sustained 

### cool malher with avorago day and night temporatures of 6S"F or lowor aftor treatment with PREpnc brand Ethophon Cotton. BoU Openerwilldelaythe boll opening rasponse. 

### Do not apply PAEPTM brand Ethephon Cotton BoU Opener if rain is expected within 6 to B hours. Ramtall within 6 to 8 hours 01 appUcation may roduce product performanco. Certified cotton soad growers should observe boU and $Ood maturity bolero troatment with PAEpn.o brand Ethaphon Cotton BoU Opener. Bolls not compfoleiy mature might oponwith treatment of PREpn4 brand Elhepbon CoUon Boll Openor giving Ioworquality seed, apraydeposits 

### of PREpTW brand Ethephon Cotton BoU Opener, whon loll on aircraft acrylic plastic type windshields for longor than t**~ur,** may react 

### with this**mat.~al,** forming an opaquo Iilm or spots on tho surface which cannot 

### be romovod bywashing wllh water or any other cleaner. Rinse windshields with wator Immedrately after each lankload of PREpn. brand Ethuphon Cotton SoU Opener has boen applied. Thoroughly rinso tho aircraft with clean watOfatter each day PREpnI brand Ethephon Cotton Boll C>P.onor

### js applied. PREpl10I brand Ethophon Cotton Boll Opener may also affect cortain painls, and if accidental doposlls on paintod

## ItfJ;ects·such lUI cars, trucks, agricultural oquipmont, otc. occurs, theso objOdS should be rinsod with water as soon as possibfo (wIth,," 1 ""ur)to**J!14~** permanent staining 

### of the painted surface. :..... • • SPRAY PREPARATION • ..:••: 

## •• Add 1/2to 3/4 of the roquirod amount of wa1erto tho spray tank. Slart agitation. Add tho roquirod amount of**PREP~;rand** EtllIpbgn Cotlon BoU Openor, and tho remaining amount ofwater. Propare only as much spray solution as can be usoo on tho d'ay 01 mixWt;

# .oe nOl allow spray solution to stand overnight. 

### Do not spill the COrlCGntratod product on spray equipment, or any airplantvntts. 

## • /lJ4Y SPillS SHOULD BE RINSED IMMEDIATELYWITH PLENTY OFWATER. •••• • ••••• 

### • • 

## • Use of a nurso tank is highly rocommonded for avoiding possiblo spills 01 concontrated lormulation on spray oquiwnegt,or any airplMe parts. ..:... ..:••: 

### EQUIPMENT CLEANING ••• •••• 

## •• 

## • Bucauso 01 tho acidic nature of this product, prolonged exposure to spray deposit will damago acryfic plasticl, cd\faIn painls. and metals. Rin$O thoroughly with a detergent and wator aU exposed acrylic plastic-typo materials (e.g., aircraft windshiolds), lIlld painted surfaces within an hour aftor exposure to spray deposits. At the end of eech day, rlnso thoroughly with a dotergant and wator aU tho molal parts 01 tho aircrall and tho associated spray oquipmont exposod to tho spray deposits. 

# 142....**~- .~~~~-~--~-** 


## PRETREATMENT WITH DEFOLIANTS l"RIOR TO PREpN PLANT REGULATOR Iftho cotton 

### is ovorly rankor laying down in the middles and good spray ooYoraga oftho bolls with PREpn< is 

### diffICUlt, II. protreatmont with dolollarns 

### wU/

### be useful to improve bolt CClV(f(aga wnh PAEpnt. Usa dosago raiMof PREprw Plant Regulator rocommooded lor

## bon opening. Road and obsorvo all appropriato labal use dir&elions and pr&eaU1ions for tho dofoliant used. 00 not oxcood a maxImum 01 2.0 Ib ailA fortho combined use as aprocondltloning treatmont fordoloUruion and cotton bollopening. 00 nol usa adGfoUant beforothoro uro sufficiont maturo ullOpGned boUs 10 produCG thodesired yiold (sa.Genoral fnlonnatlon s&ctlon on Howto Toot for BoB Maturity). 

## BOLL OPENING Spray Volume 

### Rat. (Gala/A) Conditions expected 

### 1 Gallon 

### Application**5~7** 

### days after treatment 

### Plnt.fA 

### LB' A.I. Treats Ground Air 

### Timing Hotanddry 80" Forhigher 1·113 

### 1.0 6 Acres 15·50 

### 2·5 Apply whon the number Dryand 75 to 80" F 

### 2 1.5 4 Acros ot mature unopenod 

### bolls is sulficiont to Coolbut higharthan 65" F 

### 2-213 2.0 3 Acres produce the dosirod Rank collOn 

### 2-213 2.0 3 Acres 25-50 

### 5 yleld_

RESTRICTIONS: Boll Opening
• tn Catijornia and Arizona uso a volumo ot no loss than 5 gallons per acre for aerial applications. 

## FOR pr:r:OI Spray Votume 

### Rate
15-7 days aHer' DO. 

# " las A.1. 1 Gallon 

### Air

Hot and dry 

### 800' For higher 

### 213 0.5 12 Acres 15-50 

### 2·5 ,A.P!'r.4 

### 10 7

### day~pr~r Cool

### but higherthan 

### 65" F t-ti3 

### 1.0 6 Acres 

### lan< m;,

# wl:~**;:!~~** Rank ootton 1-113 

### 1.0 

# eAcres (SGO 

### I I**'~ctlonl'** 

# "?**~t** 

### lank mIx wIth unloss 

### I,

RESTRtCTfONS: PrecondItioning for Defollatfon

• • In Catffornia and Arizona uso a volumo of

### no less than 

### 5 gallons per aCte for aerial applicalions. 00 not 

### oxCG&Cl amaximum ot 2 Ib aitA for tho combinod use as a preconditioning tmatmont for**defo~ation** and cotton

# oon opening,
• Do not usea defoliant bofore thore aro suffICient mature unopened bolls to produce tho d9Sirod yiold (50e Gonerallnformatlon), COMPATJBILITY : •••:. PREpUI brand Ethophon Conon Bon Openor is compatible**w~h** DEFI. FOlEX*, DROPP2, HARVAOE3. METHYL PARAllUON. GUTHlONr AND MAlATHION", and 

### may be appffod in sequenco or as a tank mixturo (DO NOTTANK MIX**W~~tCC~TS** II! COnON 

### IS TO BE SPINDLE HARVESTED), In some casos slight reduction in boffopening response has heerrtobseNod**wh.oIl.tiL'~** mixes with defoliantswere usod. • •• 

### •• Good agifallon 

### in tho spray tank is Gssontial and 

### a lank mixture should not be allowed to stand without agilation for.ogre than.5$Q

### J0 minutes. Road and observe all appropriate label use diroctlons and proc3utions torthe defoliants and insecticidos usdd, ••: ••• PRECAUTION :... • 

## •••• 00 not tank mix PREP"' brand Ethephon Conan Boll Opener with dafollants containing IOlflum cftMr'la1' bocauS8 this resunS In Ihe formation of hypochlorous acids which Upon heating omit toxJc t;hlOilna fum••**~·** 

## ••• •••••• WHEN TO HARVEST •••• •• 00 not harvest cotton soonerthan 7 days after a troatmenl with PREp-ni brand Ethophon Cotton Bon Opener. ••• •• • • 

# . , 

# . Observe the treated crop and harvest when optimum bollopening has boon reached, Too early harvest might rodlke

### lflft full advantage ofthe troalment and too late a haMs! may rGsult in rooucOO qualify and loss of lint which wlR drop lrom the plant.



# 143

# LIMITED WARRANTY AND DISCLAIMER ThQ manufacturerwarrants (a) Ihallhis product oonformslo the chemical doscription on the label; (b) that this 

### product 

### is reasonably fit 

### for tho purposos sot forth in tho directions for use whon 

### It is usad In accordance with such directions; and (c) that the directions, warning and other statements on this labol aro basQd upon rosponsible experts' evaluation 

### of reasonable tests of effootivonoss, of toxicity to laboratory animals and to plants, and of res[du••on food crops and upon reports of field exporience. Tests have not 

### beDn 

### madeon allvarieties orin all matos or under all conditions. THE MANUFACTURER NEITHER MAKES NOR INTENDS. NOR DOES IT AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES, EXPRESS OR IMPLIED, AND IT 

### EXPRESSLVEXClUDESAND DISCLAIMS AlL IMPUEDWARRANTIES OF MERCHANT-ABIUlYOR FITNESS FORA PARTICUlAR PURPOSE. 

### THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANYAND ALL LOSS OR DAMAGE WHICH RESULTS FROM THE USEOFTHIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENTWITH THE LABEL DIRECTIONS, WARNINGS OR CAUTIONS, 

### BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, LOSSES, DAMAGES, OR INJURIES RESULTING 

### FROMTHE USE OR HANDUNG OF THIS PRODUCT, WHETHER 

### OR NOTBASED IN CONlRACT, NEGLIGENCE, SlRlCT LIABILfTY IN TORT

### OR OTHERWISE SHALL BE LIMITED, AT THE MANUFACTURER'S OPTION, TO REPLACEMENTOF, ORTHE REPAYMENTOFTHE PURCHASE PRICE FOR, THE QUANTITY OFPRODUCTWITH AESPECTTO WHICH DAMAGES ARE ClAIMED, IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL. INDIRECTOR 

### CONSEQUENTIAL DAMAGES RESULTING FROMTHE USE

### OR HANDliNG OF THIS PRODUCT. NOnCE TO BUYER Purchase of thi$, 

### product dOGS not conler any rights undor patients govoming this product

### ortho uso thereof in countries outsldo of 

### the United States,
The US& ot this producttor avariety 01 plant growth regulation uses is prot&CIed by 

### various United States and foreign patents inClUding

• ,S, Patents 3,879,188 and 4,240,8f9. No license Is granted to use this product 

### In countries otherthan the United StatGS orfor any s9 not contomplatlld by this labol. liabilityfor patent Inlrin9Omont may rosult trom use orsale ofthis product outsido tho Unked States.

t DEF and Gulhion aro fOg/sterad tradomarks ot BayorAG, Germany. 2 Dropp 

### is a registeredtradomark of

### NOR-AM Chemical Company. 3 HalVade is a registered trademark of Uniroyal Company, 4 Malathion isatradomark ofAmerican Cyanamid Company• 

# •

AhOne·Poufenc Ag 

### Company P.O. Box 120t4, 2T.W. Alexander Drive Research Triangle Park, North Carolina 

### 2n09 PREpnt is atrademarkof RhOne-Poulene. Folex® is a registered trademark of RhOne·Poulenc

. PREpnt: hraru:l Ethephon Cotton Boll Opener (MASTER) Approved t0120192. 

## • 

# • •••••• 

### • • • •••••• 

### • 

## • • 

# ...

• 

## •••• 

# • •••

## •
• 

# .. • 

# • •

••••


# .. • 

# • • • • 

# ..

144 •••••• • 

# • • • • 

## •••••• • •



# .. .

......

• 

# • ••••• • •

### ••••• 

## • •



# .. •••••• 

### • 

# • 

# .. ..

# :.. , . 

# . p",,,,, 

### 1" •• ",'fi.M

# I~) e.

# U"'~=~p~= 

# :r.;:05'8t'" Registration 10pP

# ''''"'''cr Nom"" 

# ftEPA'

-

_ W""""ton,DC 

# 204'" Amendment

# ~7 

# . Applicationfor Pesticide:

# ~ Other 

# 153345
I'" Company/Praduct Number _AlA '2. EPA p,,,,,",, 

# I'· 

# c, G. Parker 4, ComPMYif'«:Iducl {NllIM) PM. 

## .--_..

# -- ._.- 

# o None 

# o Restri!;lmi 

## 'lenc Ag Co. .:2.!2-- 5, Namo iIltJdAdd/'&$$ ofApplicant (fndvdoZIP

### C<xJoJ 

# fb}{i), my product is simlll;ror klenlica:

# i~:~~~l~n and 

## 2 T. W. Alexander Drive E 10: 

## P.O. Box 12014 Research Triangle Park, 

# NC EPA Reg. No.**~,.-**



# o Checkifthis ($ nnewaddress 

### Product Namo 

### .1 I

### ~ Amo!"ldment

- Explain \)glow RMI pnnladlabels in rospontu to



# -**~y** IoltvrdaltXl

## ~ Rowbmiuion in rotponoo to Agency lonerdalod**-----~""**



# - 'M!)Too'Appllc411on. 

# r- Nolillcatlon· Explnin below, OIticr

-explain b&law, Uscadditional pag&{s) 11tWcouary, (FCiI" sC{;lioo I and Section IL) 

## Add tobacco to the Prep 1 abel from Ethrel Plant Regulator label, EPA Reg. No. 264-267. Rates have been calculated to apply the same amount active 

## I Aas currently registered. Both labels will now have recorrunendations fo"r use on tobacco. Also. alternate brand name request as PREP brand Ethephon for cotton and tobacco. 

# liU I" , ",",,,,,,Wlil Ue 

# ""'

..- Yes IWaw, 

# 1 2
,**~** . 

# BY'" .-- Yes: 

### f-- 

# ;;;:''''Iic

- - No No No 

# ',.,**~: NO<,~r** **If''YC$,~** 

# No"" • Certification

## mu.tbe oonl!:uncr PIld<agowgt. COfltamer 

### I 

# ,3

. Not 

# , S"*)'Oi, 

## I 5. 1 "",

.. 

# 0"",. 

# n,**B~t;b,;;"'"** i 

# ",rod",' G, 

# "'"""in HoP"",",' 

# 1= 0""""[ 

# , :

# ..::. N,,,,,, fliC 

## Registration Manager

# ~ ,No 11001"''' 

## Warren A. Davis Senior 

## • 

# : -=-**'~.'**
I certify that the statements I h31fQ madeon Ihfs form and 1111attachmontt ihl)(&iO rue 

### two, acwrato and

### compIo~": ••

# I·~"OO ! IIckoowlcdge- thaI any knowingly la/$(! or mlslcadifig &lal$(f\oot may ba punishable by fino orimprisonment

# Ct.:•• oolh under**app~oabl&** l::tw 

# :**.:::~** 

# 1')#

# CUtc~

# it 13, ntl. 

## •• 

## • •• • Senior Registration Manager 

## • •• 

# I" ",..Nam, j5 Dato 

## Warren A. 

## Davi 5 October 

## 26, 1992 

# 145

EPA 

# " _EPA**~** 

# Y,I[ow· oopy**---------.~--**


# •
. L:' PAPERWORK REDUCTION ACT -"1I0'l'!l:!E and

## INS~UCTJ:ONS PAEERWOru:; R:iSDUCTION AC'"£ HOTIgJ,: Public npcrtil19 buriWr'! fer tIllS i':1'lllecHen

## (If'1r1fcrMti~ lh"j eU1IMteci to**lWer~** 0.85 hour per**f'1l~~** lne{Vdlny 

### til$S fer 

### rwJwlfIU iNtr\iCticrra, $€l'nrehing exillting"data 

### sOW''t¢!., 9Mhiirirm awJ maintainlng the daw nemlecl; 

### and**t~{trt:lX~:',0nd** 

### "**',th~** CQll«:tlon of informatioo, send coollWnta regarding the burMn Oil,llMt", or IIrtl' other J'l6p%tt'Of Hilfr Ntl JtJ1crootien, including lH,lggentiCl'4 for recludng this b.ird«l, t<') Chief, InforMtltl¢l'i Potiey srarn:h, HF2D, 

### us, 'tmi**,':'~h:!tectioo** Ag!ltlCy, 401 Mtit!'"t, SU, Viltrldnsten, be 20460; ard to- the Office of Infornaticn l>rn1 Rli$t!letory AHeirs, leli 

### 6f H"na1;mMnt tlnd Budget, lJushington, DC lOS{)3. INSTBUC'TIQN§: Thls form i& to 00**Ut~** f<;w alt appUcr.tiwm Tor fh'U regl§tf<l!tioo, end ose reregistration, &liIYldmnt,**r~ubmfllsion,** to applicatIons for**~tifitatiOh$.** fih4i printed labeling,**r~registratlon,** etc. In ortlct to process an**~ppticntlon** for 

### a 

### new registration submitted 

### on this Torm, the**foll~lrt9** material**~~$t** 

### accompany the application; 1. Certifictltion \{ith Roop«t to CltatHm 01 /{,ijta {ErA fem M?iF29}. crf rwt**~>:oo,..ned** by 40 efP: 152,t1 {o} (4)1; 2. Confidential StatefOOnt of fO!"1all./l (nM FiWm 11570'4): 3. fOrNlat(fr's EXlWptlon Stlltetmnt O,p" 

### ftrtm**a!!'11:H~7);** 4. flv« CopiM of draft {.meling; S. Thr@e copies of nny ddta submftted; 6. AlJthorh:lItfM tetter uflcre applicr.ble; 7. Hatrh::u; .mere applicable. SuI::<i1ill&i¢l"j of labeling

- labelIng should first be s5.Jhm\tte<:l in the form of draft tabels with lilt applications for rMii reglstr4tion. SUCh draft llJb,2ls may be in the fONl! of typ«.l lOOcl text co 8.5 x 11 irn:h**~r** or a If<<kup Qf the proposed l.l. if prepar¢d /Hi 3l11OCi:up, it should be corn:;:tNCtro In such It fiay as to facilitate storage in an 8.5 x 11 Inch fit*. Mockup tabels signlflCat1tly -.lttar than 8.5 It 11 inchn should be II\Q(Z'1tOO on 8.5 x 11 inch IXlpEf far su!;.:milwiMl. stJ:af/udon of Oatil**~** Data**l;-utmj!~ed** in t\JPPOrt of thit application must 00 suJ..:rl1itted in accordance with Pit Notice 86·5. 

### §PECIFIC INSTRQCTIQN$t rleMe read**th~** im:tructiom listoo bnlOloi bcf()rc c<'lll'9ll.!ting this ilppllcatlon. first determfrm the typa of regIstration action, listed in Glock A, for whith you are su/:nittlng this bpplication. fer • appliclltiern; sub!littlXl in conrwcticn >lith "<!II< R0QistrMf;:m aetiW'l$, Scctlom I, Ill, and IV lru$t**~** coapteted by the applicant. For applkatiotm subultted in COfif'lW.:tlon with**~** rC!listrllticn actions, rC(l:tkmitsions, rrotlficatiom, rercgist!'"aticns, etc., Scetlons I, fl, and IV IW$t be**c~leted** by the applicant. 8lock A

- Cheek the appropril'lte actiO!'! for which yOtl art! submit,ting thill fom. 

### SECTION I'- Tllfs lIect!on IllJSt be coopteted, as ppplicable., for all registration**m:ticn~.** 1..**~/Pr«lJc:t** Murlber

- IMert your**C~~,** if O!'\C has be«\. ll$Sigl'lW by EPA. Thin-**~r** MY have lAY! lIsllign,ed to yeu tiS n I»sic re:gilltrant, ill di!l,tributor, or 3ll ij.O**e.!itnblrsh~t.** If ytx.lr product b rllilhtered. Insert the**P~t** 

# -. 2. EPA Pl"Cd:Jct Kaoager

- If knO\oil'l, f itI' In th!! nUM and PH r.urber of the EPA Proouct Htmager. 3. propoilCd ClDS&iHcatioo • Specify the propYSed cl.uuificIHim: of this product. Ii. Product 118IIIIIt

- Enter the c<:.$pletll' pro¢.lCt mme of this pollticiM IIII' It will apj')¢lIr on the llibel. thll' noom I!lU$.t t» specific to this product only. Duplication <)f rumQ is not permitted M!1iI'l9 produets of the $1lI!\e**c~.** 00 IWt ff';Cl:uOO any brand MIlle or ccapnny line oosigf)l\ltjoo£.. S.**w~** M'Id Mdrus of Applicant

- The rnme (If the fim or porsGflllnd nddre'M shown in yoor applic.a.,tlOf1 is- the penoo fH' firm to i1han the reglstratioo IOllt be iss\J1Ul. If you lire acting in bUlatf of another party, you !lM>t,submit ootherlzatlon fr01!l tlUli\ party to net for them In rQ9i$tratioo fflIjtteni;. An appl icnnt flOt rosiding in the United Statu must haw .en mltnodud agent residing In the Ul1fted States to act for them ill al! registratlOfllmltters. rhe twIie lind tOO'piete rmllina address of such at'l agent lrutt**aGc~** this apptiClltl(m. 6. Expedited Rev-iei

- filM section 3 (c) 3 (8) previeWs fer exp«ilted rflvle1l of nppt ieadoo; for r¢ji!Hration, or**~t.** to existing registrations, that nre similar or id¢ntlcal to O!hllr**~!l.tjdde** products thnt are C1JrfClldy r'J-gfstercd wi!!'! the EPA. In order for your "pplication to be eligibte for ,wpedlted review, you MAt provltk'us with the'EVA'Regil>tt4tion Ntrrber liM prodJet**~** of the prodl.lct you bell¢Y<!'**i~** ,limil"r to {)!'" idtotfcill! to your product. the product 1N$t be 1I1mHar or identIcat fn both fOllallation mrl labeled l.<g'Hl. 

### SECTION II**~** Thht section I!1.Ut be cOllflteted tor alt appticatioo;**§.~itud** ttl 1lfflffid the reoJistration .OfIly of a currently register(/d prodtict {koon:iY>tnt}, for a rem.lI:rnissioo in resporulc to at'! .Agency Icnllr, fer notiHcntfom; to the Aj)«li:'Y, ior 1he**~lllsion** of final printed labeling, for reregiuratlrn and for arty othtr <lctioo th!!t pertlli'rw to II**~if ru·r99istst'Jt~.**  Thfs z"lCtion is.ill!! 1Q kg 0000 fcr u MY appticutb:/(1 for regilltrat!oo. 1. Swject of $lbiIhwion**~** Check the I:If9ticlible block &ld provide the Agoney Ictter date if appl"t'lprlate. provide 0: briel:**explanat.i&;~'.the** purp«le(s.) for the submissjon. such lIS "the A&Jltioo of a alte, pest or crop (ap<l'cifY)"i l1am;;nd thl**Confident'Ir'tat_~t":""I~:lFll'Ula** by

.....; "rercglstratico Sutmil!l;:ion";**9~rlll** lobel rfNiriioo of use dlret:ticns." Attach a scparatcotpaae if afdi"tiOlJ't s!»,ce is r;(lelkd. 

### • 

# •• SECTrml.tIt 

# (P$lcS;aging and container Information)

- ThIs SectiOn lWSt be

### c~leted for 1111 applicatlorf**~tted** i"'C\'l!'IIWCtlon IIfth new registration or appllcabte**am~r;ts.** 1. Type ofz..t:taQing

- CJwcl;;

..the awroprinte bled. if your prodt.let wfll be pilcbgoo in the indlcatoo Pilco::aging type5. lrdicate**t~** stu**of:th~lndividuat** packets and**~r** Pfir retail ccotaiMr. 2. Type of**Rftait.tootaf~'''rrdielllte** type of container in Iffiieh product wilt be marketed. 3.**LocatiortS't~** Content$

- Spedfy the IWt contents of lilt retail cOt'ltainerll for your product. 4. siu(s) 01 

### ie'tall COntainer

- Speclfy !he rmt t:ententll of ill**r~tilfl** cor;tahwrs. for yoor prcduet. S. LocDtion.tf.l1cl Oit'eetions H Indicate the l«lItion of the !.me dir«:tit:.lrW for yoor product. 6. Ibrner irrllhidl. labet is affixed to pNXluc't

- lrdicllte the method prc.rciut:t labet 'it, IItta<.:hl}d to ruaH coouiner, 

### SECTION 

## IV (Contact Point)

- This Stx::t1on Il'USt be c«l\Pletod for all I•••, new products reglstratioo, rMIub;\hsien.**"1!Itt·too,~** nr&gi5trlltioo, etc. loS.**setf~exptanatory.**

6. EPA UM only. 

# '146

# :~;,,~(~:,**'~**

# .**~ ----~**  ------ --.---**--.~--JfP'O--- "o/~-** **-~--~** ---**~-,,--- ~'**  -,-,**'~ ~** 

, 

# , 

# , 

# . , 

# ,

" , 

# ,,.!?"''44'/ •

# ~~'"" , , on 

# "' ,

# .~& 

# PA 0"""**,~.**

# ~ lopp 1000,""

# """b,,, 

# t Applicatron for 

## Other 

# 153345**A~'"** 12 

# c**j~~J:'** 

### _____ 

# o"mw**O~cstrictod** , 

# I', 

# ak 1\ IPM. e 

### flo ;,' ;;1,' 

# - i5. NamaandAddro'$ 

### " 

# c_, 6, Expedited Review. In ' 1FIFRA Section 3(c)(3) 

## 2 T

## A1e~-~ncler'''f)r-i 'Ie: (b)(i). my product is similar or idenlical in composition and laboUng

, I • 

## \{. 

# I 10:**r~O~** 

### Box 

### 12014 

## \-- !{C'sean:h TriStligle P.;tk1 

## '" EPA Reg. No.**,'l,~**



# o '

. Chcckjf,lhl&isa nowarhro'l!i Product Nruoo 

### III ,



# - Final

### ~ 

# ,E,._'" bek<w



# - Ag""" j Rt:wbml$$ioo in roSpotlSO to Agl'mey killCrdated



# - "MeToo'Applicdlion. 

# r-- :_

. -Explaln balow. Other

- oxp!aln below.
Uso additional pagels) iI,rcoo"ary. {Forsection landSocOOrt It) 

### Add i., •
_ 

### to the Ptep 1&001

# f~~,):nhn;l Pl\\flt Regulil.tor hbCl 1 

## EPA**Re:'~h No~**  

## 264-267**~**

### Rat~s 

## have been c111cu1ilt-ed tp\u,

.. thG**'5m~c** 

### ,>1wlJunt 

## acti!e 

## I A

## as 

## currently registered. Botn' labels will now**~ilve** 

## - 

## ons TOr use on tobacco" i\bOt 

## a1tBrnate 

## brand I**~nmc-** 

## requEst 

## as Pf£[P D ""'

..



# t,::' for cotton Jnd 

## tobacco:

, 

### , f

" , 

# ;mI" 

### !lnl

.


# , , '''1 

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### mustbe IoVgt CQI'llainor 

### PACkagc-W9l- eontainCf



# -

. 3_ ' NetContents 

# I', Stte{.) 

# • nl";" ' 

# 0, 

# ag::C;';

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, ""_'0_labell,**"",~n** '0 P""",,"

# ~~ DomorL..... _,-..l 

# • •

iSt\'Btion

# Hnna9al'~-C""") I';.,"'" n

..' Harren 

# , D-Jvh, SCil'lof' 

# '" 

# •• 16

# :='~"'<lioo Icertify \hilt tho sl8temtlnb Ihave mado on this form I&eknowlodQa thaI any knowingly 10100 ," mAY bo punistmble by '0 ••• (Stlftnpod) both underappliQllibielaw 

# t ....

# l>i~/(* 

# ;/;/2**~**

# .. :3. TIlle 

# •••• 

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-**Sent~r** 

### FU:ij'l:str<1z'ion 

# • • • 

# .. 1 " 5. OnT<> &ig(n:!t 

## " hI, 

### tH-; i '", o!i.. t,;i !Jr J , 

# 147

<"A' Wh"", EPA V,Ik<w '

# . • 

# • • 

# :" 

# " PAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS 

# • PAPERWORK REDUCTION ACT NOTICE: Public repcirtfJ'li burdm for this co!l&Cticn (ff InforrMtion I' Ktil!l4ted to average 0.85 hour per nspmse, InclUding tIme for rIWitwhtg lfUtruetiooo, t'li:lrchiTl9 existing data llOl.lf'CtHl, gatlwFlnu ;md maintaining the dnts**~.** end**c~;t!ting ~**  rlW'i(tU;ng the I;oliccticn of ;rlioNMItien. Send**c~nts** regtlrdlng tile burden ost;mau or any other IHiput of tId; collection ¢f information, including :I<\Ji1gellt!um for reducing thi\; 

### burden, to Chief,**Infor~tion** 

### Policy**arn~h,** 

### rn-223, u.s. Environmental Protection**A!i~.** 

### 401 M Street, SU, US3hington, DC 20460; ttnd to the Offic<.< of Informtlthm tmd Regulatory Affalrs,**Offlc~** of lfunagetM-nt Wid Sudgtt, Washington, OC 20503. 

### INSTRUCTIONS: T!;;:; form is to be used for all IIpplicat;Ofl& for MY**r~itt:ration,** end UM 

### rcrCilistrlitloo, tmaflf.beot, ruutmlsslon, to applfcotiOflll for rKltifications, fir,j! printtd llll.mllng, reregfstfliltion, etc. In order to 

### proceu an l'lwlicatfon for a MI4 registration $ubmitt«l on thIS forM, the- followlno mat.:>ri&l I!Vtit accanpany the application: 1. Certificat;()(I with ReSlwet to Citation of Datu (EPA form 8570·29). [1f not eX"ptw by 40 CFR 152.81 (b) (4)l, 2. Confidential St&t01MOt of fOnlllJla (I:PA form 8570·/j); 3. FOrnllotor'. EXOO!ptioo Statemwt (EPA forn 8570-21); 4. five coplell- of draft**la~I** lno; 5. Tllree copies of 1m'{ data sultted; 6. Authorlutlon letter where ewllcflbiej 7. Matrices**~ere ~licoble.**  StlbIII5Slon of Labeling· L4beling should first 00 !!UI::«iltted in tile fONII of draft labels with all applicatlOO$ for new registration. SUCh dreft l&bels may 00 In the form of typed label text on 8.5 x 1l indl papor or a mod:.up of the proposed**l~l.** If prepared as a 

### mockup, it should be constructed in Guch • 

### way as to facilitate**storag~** In 

### un 8.5 

### x II Inch file. Mockup labels s.l9tlificantly 5IMller thno 8.5 

### x 11 irw:ne$ shoold 00 moooted on 

### 8.5 

### x 1l im:h paper for subniGSiOl'1. Stbafssfon of Data

- Datil sub'!!;tted In stlpp¢rt of thi!i application ItJJSt be subnitted in M:corclarn;e with PIt Notice 86-5. 

# •

SPECUIC INSTRUCTIONS: Please reM! thO) instructions listoo below Ix!fore coopletlno this applictltion. first detel1!lim the type of registration action, lisud In Block A, for which you are subnitting this application. for • npplications subnittEd in cOflMCtion with New Registration III!tlOlW, SectiOf'\$ I, IH, and fV M.l$t I» cC(lljlleted by the applicent. For opplicatlOO$ su!:mittw in cOf'li"lt:ctioo with BfOOI'ldtld registration act;OO$, resubmluioos. notifications, reregistratlOflS, etc., Sectloro f, If, ao:I IV mJSt I» conpleted by the applicant. Dlode A

- (;h4C[( the flppropriate action for which you are sul:;mlttfng: this form•• 

### SECTIQN I - ThhJ section nmt be c(lll'pletEd. liS applicable, for aU roti:>tratfon actiOfl$. 1. CaIpany/Procb:t 1M'ber' IMert yoor CcRpany MUIibcr, if one hl)$ b«o 4nfSMd by EPA. This f'lI.ZIlber JIISoy hllw beenJIJ>slgned

, to you a£ a basic regtstrMlt, to distriwtor, or.$ 30 utabillihMnt. If your product Ii> registered, 'intert the ProdJet 

# -.

. 2. 

### iPJ. Pror.b::t Monoter

- If known, fill In the nllllllf and 1'K l"IUtbor of the EPiProduct Manager. 3. Proposed Clan-ification

- SpttHy the proposeJ clnsi>fflclltl,on of tltis product. 4. Pn!du.;t

.... - Enter thl!" complete**pr~t** rn!i!Ie of this pestioslde as it wHl AfJPIlar on th/f lebel. lhe nMIt !!'Ost be * specific to this product Of!ly. Dupllcatlon of names h Mt permitted among pl'oCuct& of tile**s~ c~.**  iooot include afr( brand /'IaI'MI or**c~** 11M ck$!gMtloru;. .'-" '.

5. W- $1d AI:Jdn!oN of Applfcoot

- The name of tile firm or persPn IIlld iKkIrKs shown in ywr appllcatiqa h tile per'Of! Of' firm to whom the regiStration will be IssuOO. If you are acting: in behalf of another porty,.yoo IIOGt 8I,Ibmit authorization from • that partY to act for them In registration matters. An applicant not ruldino in the United States II't.l$t4!llaw an

authorized**~t** rdidlng In the unltt!d States to IIct;or them in 

### all registration ootters. The nMII! tmd**c~Ictte** lNIilino .address of such an agent IWSt a<:cOO'pGny this cppllcotion. 6. Expedited Review

- FfFAA saction 3 (c) 3 (Il:) pravides for expedited revltii of applicatlOO$ for registration, 01'**~** to existlns Nl91stf'etions, that**er~** similar or identical to other pesticide products that are currentlY • .Jetlistercd 

### with. the**EPA~** In order for 

### your appllcatlon to be- eligible for expedlted**revl~,** you**~t** previde WI witl'l"tite EPA Registration Mi.lWer and product na.'f!Q of the prO<luet you believe is similar to Of' ldentiul to yoor prodl.let. The Pl"oduet III1Jst be: similer'tlr identical In both fonwlht;Grl lind labeled USIIIL 

### SECTION II

- This s@ctionmu,t be cOlIPleted for all &pplicatioru. submitted to IIIOOf'd tile regi!:t{'lItion only of tl currently register«fproduct (,\m(!ndmmt) , far j!j rtfiu!:;mis:t;fcn in reGpoMe tQ lin A9ency luter, for notHlt<lltiOlUl to tile**A~y,** for the subnisslon of tilWl prfnted llibeling, for reregistration Mod for any other action that p.l!rulni' to a f!?fJcHip**!f!·rti!i'~~.** Ihls**~(;Ct!on** fIt!!2! 

### 12.lli!:**u~oo** for a rww application for registration. l. $lbject of SIhIiSGion' Check the: applicable block and provide tile A\lMC'( letter date if appropriate. Provide a brief rue:plantt'ftlto-l1f the PJl'poae(&) for the subml.!lsion. such as "the Mtlitlon of a site, pest or crop (spt!l::ify)";**,,~** tile Confidem.oi••**$tll!t~"""Fonrula** by

.....; "reregistration sutmlssiOf'\I!; 9_ral label revls.1on of use direetioos." Attach 

### •**"epo:r.~ ~**  If**~itllmol** IIp.l!ce Is- M«ied. 

## • • • ••**SBCTIOl1.~II** 

### £r4CtKaginq 

## and Container InfOrmation)

. this S@ctlon nust be cOirpIetoo for all applications 

### ".,tted',jp·cCl"otWCtion with 

### new rcgistratlon or applicable**~ts.** 1. Type**ot~fns** 

### -**a~** the appt"opt"Iate bllX:k If Y«JI" product will be p0Ckagcd In the indicoted packaging tyPes. Indlcat. the site 

## ttf tlte Ir.dlvidutill packets and ntl!'ber per reUlIl container. 2. Type- of .retail COOtai':"r I!'Idicate type of conhiner In whlch prodJct will be INIrl:eted. 3. llDC4tf"'·CII 

### let CGntents

- $pe<:ify the net contents of alt ret4il containers for your product. 4. Sizees)·4fI'J:daiL Container

- Specify the net conteots of all rotail containers for yow prOOill:t. S. Lce.t[f'!**<i.~** DircctfCM • lndlcate tile**loeati~** of the we directions for your**p~t.** 6. Kannel'" '"' wbidJ**l~l** Is affbed ta pro:xb:t

. lrodlcote tile method product \eJ:xo.l 16 .ttachlld to retail container. 

### SECTION IV 

### (Contact 

## Point)

- This Sru::tlon IWSt be ctq'lleted for all Applications for R&g;Istratlon actions, I.e., new productG registration, rHubnfs8ion, ul\le-too," reregistratfoo, etc. l·5. self·explanatory.

6. EPA "', only. 

# 148

# ------ ._ ....

# _ ..

# _ .....

# _ ....

# _._._ ...

# _------_

....

# _....

### - ...

### -**~- ~-**  

# , 

# . 

# (ftO RHON.E-PO(JLENC**,~/~~~** 

### - ,""'"' 'If



# •

• RHONE-POUI-ENe AG COMPANY



### ETH-92- 

### i G 

### Oclober 2:, 1992
l), 

### S, Environmental Protection A.gene! Ofiice of PesUcid'.? Program 

### DOCl.ITifnt Pl"oCt?'ssinil Desk Koorr 266 A, Cryst<'ll 1"1011 No.2 1921 

### Jefferson D::Jvis Higrlway 

### ArlIngton, VirginlJ 22202 

### Attent1on: CynthIa Glles-Parker 

### Product**1~I,m21g0r** 

### (22) Fungicide HerblCide Brana, PegistraUon OiV15101) UI7SQ3()



### m:· 

### UDe; j\rr,er;drt1(>nt f

### 01' Prt-}) (!) 

### c:'ar;cJ Ether;·hor, tor 

### cotten EP/\ 

### r{eg_!'\c 264'/[15 

### l\i>pend8d is elf) 

### applic9t

### h.'n to dr(a':CI·j the 

### PrE'P 

## late! by 8dd\l\g a lose 

## ,,:-colrmeM1Jtion ror tCZiac[o rhls use**I:~** 

### (1)!T(>(ltly reglsll'l"ed 01\ our Ethrel Plant regulator Label {EP!\ Heg. No 26.t!-2G7) 

### \'1(; hJvi? fr,;)intameo thc· SJn'e '..;5(> diie(tlOrL$ and 

### JI-:Ho'nded I'ate::; If) CDmperLsate 

### ror the change ill 

### the pounds activE' 

### con[airled Ifl 

### the Prep and Etf;rt.'l formulat Ions Both 

### labels,novi recommenu the 

### same (jrrolJnt 

### cf i1CUV0 ingrodlent 

### per Jere for 8ppl\catl0n 

### to tob,ICCo \'/r; 

### are al$"" renuesl.lng 

### an clltema.t0 

### brancl 

## ncrt,e fOI- Prep to 3d;Jfi:':;':> 

### n-H? addle lon of tobacco 

### The alternate brJIl(i name Is Prep branrJ Ctnepl,ol'l 

### fer CoLtOI, ZInc: lob;:KCO 

### I

### rvou 

### have- any 

### (lUtsl ions 

### 8]eelS'? CrYLtact 

### rre- profflptIy H\'ink yc·u for

### V'JUr aSsistJnc;:.

.

\.,·'arrel1 A D:;iVIS**~:,,;f\**

### iw PeiJ:

## str**~1**

### Lk,r\f" af

### 1<°19"

..r 

### • • •••••• 

### ••••• 

### • • 

# ·..... .... • •• • •• • • • •••••• 

### • • • •

•• •• • 

### •• • • •• ••• • • • ••••• •• • • 

## •• • 

# ..... • •• 

### •• •

••••
P.:H!D.\ IZ< ',j 21'S**';',U,~.',~U'** f+;'

..**~** GESU,nCh**:;~'.\rjG,_~** I',V'>!< '1

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### •• • •• • • 

## ••
;'HLWlr'; (.**~;;'1.** If.!- /,hU!f<" ·'1**,,~:,"-** ASC v, F, "" ,< " 

# 149

# • .pREP TM

# BRAND ETHEPHON FOR COTTON AND TOBACCO
For Commercial Use Or Agricultural 

# Use Only. Not For Residential Use ACTIVE INGREDIENT: Ethephon (2·Chtoroethyl) phoSphonic acid'

.................,.....................................,55.4% INERT

..............................................................................44,6% 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO
PRECAUCtON 

### AtUSUARtO: SI 

### ustod no 100 Ingles, 00 

### use est. prodUdO hasta quo III informacion on Ia otiquota I. haya sido oxplicado



# STATEMENT OF PRACTICAL TREATMENT IF IN EYES: Hold O1felids open and Ilush with a gentlo stream 01 walor lor

### at least 15 minutos. Got modical attontion, preferably an 

### ophthalmologist. IF ON SKIN: Immodiately

### wuh skin with plenty of soap and 

### water. Romovo contaminated clothing and 

### shoo$.. Wash clothing separately beforo reuse. IFSWALLOWED: Do not induoo vomking. Promptly drink a large quantity 

### of milk. egg whit". gelatin solution or if

### Ihas. are not 

### avallablo, drfnk 

### large quantities ofwator. Avoid alcohol. Call a physician immDdiately, IF INHALED: Remove victim to frash air. If not broathing. givo artificial rospiratlon. Administer oxygen if necessary. Got modica! attention. 

# PRECAUTIONARY STATEMENTS DANGER HAZARDS TO HUMANS AND DOMESTIC ANIMALS CORROSIVE. CauSOl (fj8

### and skin damage. May

### befatalff absorbed through skin. Harmful if

### swallowod or inhaled. Avoid breathing



### • spray mist. 

### 00notget in eyes. on skin 

### oron clothing. 

### WoarfuR length trousers, long slewedshirt. protoctivo gloves. and gogglesor face shlokl when handling. Change 10 clean work 

### clothes daily. Wash thoroughly with soap and

### waterafter handfing and beforo eating. orsmoking. Remove and wash contaminated clothing boIoro rouso. Koop awayfrom dam.stir:: animals. 

### NOTE TO PHySICIAN Thera 

### Is no spocIflc antidoto. Ailirealmont should 

### be based on obsorvGd $lgns and symptoms of distress in Iho paliont. OVoro:tposur. 

### to materials otherthan this product may have occurrod. 

### 'Victims ofsever.overexposure, by 

### inhalation, should bG kept under medical absoNation lor up to 72 hours fordelayed onset 01 pulmonary edema. In avictim of

### over-oxposuro by

### iogostion, careful gastriclavage is 

### raquired duo to tho 

### posaibmty 01 stomach or esophagoal perforation. this matarial is an acid, but use 01 alkaline 8ubstanoos to noutralize 

### it Is contraindicated.


### • • 

## ENVIRONMENTAL HAZARDS :••••• 00 notapply

### diroctly to water Ofwetlands (swamps. bogs, 

### marshes. and potholes). Do not contaminate waler

### whaQ**~sing** 

### 01 equipment

### washwators. •••••• •••••• 00 not contaminate

### wator usedfor irrigation 

### ordomesticpurposes. : :: • 

## • • 

## •• • 

## •••••• ••• 

## USE PRECAUTIONS :: ••• Do not apply 

### PREpn<i brand 

### Ethophon Cotton 

### BoN Openorthrough any

### typo of 

### Irrigation systom. •• • ••• : 

### Avoid spray d,ift to noorby crops as this produc1 wUl cause modifications in 

### plant growth. Plant injurY

## 0;

## rGducod yields

# "'vill result. 

### •• • Do not plant

### another

### crop within 30 days 

### afterIreatmont ••••• • •• Mix only tho 

### amount of spray you oxp&d to usa each day. 

### Do not sHow mixGd 

### solution to $land ovornight. 

## •• • •••• 

## •• • •• • • •• 

# 150

# , DIRECTIONS FOR USE II Is a violation'of Federal Law to UN this product In a mann.,- inconsistent with Ita laballng. 

### Rnd entire labill bafo,. using this product. 

## REENTRY STATEMENT MixotS, loaders and applicators must woar a fun faco shield, Ioog ttousars, long sleoved shirt, gloves and boots 10 avoid as much skln and eyo contact as 

### posslWe. 

### 00 not entortreated liolds within 

### 24 hours aher application unloss 

### protectivo clothing is 

### wom.

STORAGE Do not contaminate water, food, 

### orfead by 

### storage ordisposal.**co'.~;n~'** is 

### broken orcontents have 

### spillod, foUow all precaolions

### indK:atod above 

### and

### clean up imm«fiatoly. aefore clOMing up, 

### length trousers. 

### bog sleeved shlrt. protoctiva gloves, and gogglesorface shield. 

### Soak up 

### spm wkh absorbent modia such earth arothersultai»e material and disposeofwaste at an approved waste disposal facility. DISPOSAL wastes are acutely halardous. Improperdisposal of excess p8slicide, spray mixture, or rinsato 

### is 

### a violation of Federal 

### Jaw. Wldte. cannot 

### bedisposed of by UM according 

### to label instruction'S, contact your Stato Pesticide or Environmontal Control orthe Hazardous Wasta ropre&Ontativo 

### at the near.Sf EPA Regional Olfico for guidanco.



## GENERAL INFORMATION COTTON 

# , 

# . a sanitary



### Afoliar spmyol PREPNbrand Ethephon will accGlGrata openingofmawr.urlOp(lnOd cotton bolls and enhanc.dofo/lmion 

### which 

### can rosult in earlier harvest

### with an iocroased reoovorabfe yield. PREf'Nbrand Ethophon tteatment on cotton allows incroased efficioncy from a**once~vor** harvest. TOBACCO**(FLUE~CUREO):** A lofiar spray of PREPN brand Ethephon promotes early, uniform**"yellowing~** of maturo lobacco. PREpnI reducos curing titrKt, allowing mora el1icient use ofcuring 

### bam spac.. and increased control over harvest schedules. SPRAY PREPARATION 

### Add tl2

### to 314 ofthe required amount ofwatorto the sptay tank. Slart agitation. 

### Add the required amount of PREPN 

### brand Ethophon, and lho remaining amount ofwaI.r. Proparo only as much spray solution 8$can bo usod on too day of mixing. 

### 00 not 

### aUow spray solution tostand ovemight. 

### 00notspinthe concentrated product onspray oquipment, or any airplane parts. 

### ANY SPillSSHOUlDBERINSED IMMEDIATELYWffil PlENlYOFWATER. Use ofa nUrHtank is highly recommended loravoiding JXlssibio spills 01 concentrated formulalion on 

### sprayequipment orany airplane parts

.

• COMPATIBfLITY , PREPTN 

### brand Elhophon is compatible with 

### DEFt, 

### fOLEX&', 

# DraW. Harvade3· Mothyl Parathion, Guthion', and Malathion·, and may ba appiod in &OqO&l"lCOO(

### as atank mixturo 

### (00NOTTANJ( 

### MlXwtlli OEStccANTS F COTTON IS TO BE SPINOLEHARVESTEO). In some cases slight rGductkln In boll opening response hu boon observed when tank mix.s

### with deloliantsware used. 

### Good agitallon In the spray tank is essential and atank mixture should notbe allowed to stand without agitation for more Ihan 510 10 minutes. 

### Road and observe all appropriate !abol us. dlroctions and precautions lortho defoliants and Insodicides used. NOTE: Undorcertain conditions. 

### tank mixtures 01 PREpnt brand Ethophon with doolo::ants containing sodium chlorate could result in tho formation of hypochlorous acids whichon healing wit( emit toxic chloride fumes. EQUIPMENT CLEANING Because ofthe acidic nmur. of this. product, prolonged exposure to spray dopos/t 

### will damage acrylic plastics, Cfrtain.paints, and metals. •••••• 

### • RlllSethoroughly with a detergont and water all oxposed 8ClYlic plastic-typo materials (e.g., aircraftwindshields), l/iQg,palnted surfaC&$ within an hour after exposure 10 spray deposits. •••••• •••••• Attho end of each day, rinse thoroughly with a detorgent and water aUth. metal parts of tho alicraft

# aoo the asaociatod $pray equipment exposed to the spray deposits. • • ••• 

### •••••• ••• 

## •• ••• 

## • •

•• •••• • • ••••• •• 

## • • •• • 

## ••••• 

## • •• 

# ., 

# . ••••


# .

, 

# . • • • •• 

# 151

### EXPECTED PREpm 

### ONE SPRAY VOLUME APPLICATION 

### USE CONDITfONS 

### RATE GALLON 

### (OalafA) TIMING PREpm 

### ,LBS A.1. Ac,

.. AI," PREprw 

### Hot and

### dry 

### soa-For 

### 11/3 1.0 6 

### Apply when the number 

## ?f Boll Oponer· higher 

### maW'. uno".n.d bol:li; Dry and

### 75 10 80°F 2 1.5 4 

### f5·50 

### 2 ·5 sufficient to produce d8$Jred crop. SGO 

### below Cool

### but above 

### SS-F 2213 2.0 3 

# !i;j' of boll maturity.

!

### Rank ""Hon 2213 2.0 3

# ~,~**~** :"1;:':'" PREJ»W + High soil moisture 

### ,/3 0.25 

### 2' 15·50**5~** 

### to Apply 

### 4 to 

### 7 days**prio~** 

### to FOLEX· High fertility 

### 1e

....

### 1 PAEpni boll

. 0.lolla"1 Tank 

### Rank cotton 

### appl""ion. To be

## US~~:

Mix a' 

### 'treatment

### n~.i~.~~.of PREpN PREpn.+ Dropp2 High soil moisturo 

### 1/3 0.25 24 10 

### ·50 3 ·10**~y** 

### " to 

### 7 days**prio~** 

### to Defoliant Tank High lartllity lovel PREpnI boll

. 

### Mix Rank cotton application. To be**uS.ad.~** 

### a

# ser~**~!(.atmell!.·I~~~** not in of PAEpn.
Pr.·Condf1lonar Hot,dry,

### above SWF 

### 213 0.5 12 

# I**~PJ>Ir.4** 10 7day.

### p'io~IO 

### fo, DefoU_tlon 

### Cool, 

### above ssoF 1 1/3 1.0 6 

### f5 

## ·so 2·5 

### II

. lOp Rank cotton 

### 1 1/3 1.0 6

## ~,~p . " of!,,"Iom

## c,~p**~nd ~lIow$**  

### 10' i 

### ·Pretreatment With Defoliants Prfor to PREpno: BOll Opening Treatment If

### the cotton 

### is overly rank or laying down in 

### fho mlddl••and good 

### spray coverage 

### ofthe bolls with PREPD4 

### is difficult, a pretreatment with defoliants will be 

### usefulfo improve boN coveragowilh PAEf»M. Use dosage ratDS of PAEpn.brand 

### EthophOn Cotton 

### BoU OponGr recommended for boll opening. Read 

### and obsorve an appropriato label use directions and precautions fortho dofoliant usod. "In California and Arizona use avoklme 01 flO 

### 10$$ than 

### 5gaHons par aero loraoriat applications. 

### Boll 

### Maturity

• A

### boH is mature whon it 

### is too 

### hard 

### Dbeoontod

### whon squeezed botwHO thumb and fingers, too hard to be

### sliced with asharp knife, and when the seed coat becomes light brown in color. 

### Use Limitations Do not

### oxCOGd a maximum of

### 2.0 

### lb. aiJAforcombined us

..of 

### PREpnr paracre peryear. 

## eon Opooing: 

### Do nottank mix: PREpN brand Ethephon with adosiccant 

### H tho ootten is to be

### $pindlo harvested. Pr• .condition for Defoliation: 

### 00 not tank mix PAEpnt**w~h** 

### dosic:cants unfess 

### ptant dosiccation is required. Do not use 

### a dafoHant before tho,. is sufficient maturo unopened bollsto produce tho desired yiokf (see GonMallntonnation section on howto 

### test lor boll maturity. WHEN TO HARVEST 

### COTTON 

## • • 00 not harvest cotton $OOnorthan 7days aftoratreatmont 

### with PAE.Pm brand EthDphon CoUon Boll Opener. : ••••• Ob$orvo the

### troated crop and harvestwhon opIimum boll opening has bean reached. 

### Too earty haIVost might roowaU1e lull advantago ofthetreatmont and too late a haMlst may tosuh 

### in roducod quality and 

### loss 01 lint which wilt 

### drop f;:WJbG plant.· ••••• 

## • •• • •• • • 

## • •••••• • 

## • • •



# .. .. 

# . •• • 

# · .. ••• • 

## •• ••••• 

## •• 

## • • 

## •• • ••••• 

# · .. •• •



## ••••



# .. 

# . •• • 

# · .. 152PREpllol**.s~r.y** 

### Crop Plnta/Acre

° 

# Acr. Directed Spray 

### 1 If.l 5O-1l<J Application

Over-The-Top 1113-2213 4O-1l<J Application

USE 

### LIMITATIONS 

# TOBACCO (Flue·Cured Only)

Specific Direction.
Use drop nozzles, TG Of

### OC $pray tips doslgned 

### to apply 50 • 60 

### gpa al 35-40 psi and al Irac10r speed of 

### 2·3 mph, Use 

### 2 nozzles par row; one on each side of

### th& 

## rowdroppod lowenough

### to direct the**spra:_~o** 

### the loavos 

### to be 

### ripenod and harvested, Thorough spray**~rth** 

### a dilectod spray. 

### be sure to harvest 

### all leaves
Treat only when leave. remaining on the stalk are maturo. To ensure romaining leaves- are malure, lost spray several tobacco plants as doscribod undertho section ·Proper TIme of Treatment.· U

..lhe IowGr rato in a normally mature crop 

### wh.., oxporionco Indicates thai minimum ripon'lng inducementis 

### requited. Use

### tho higher rale when the crop 

### Is heavy and 

### has a lendency 10 be more rank or when tempor81ures are Iowar Ihan 

## normal. Always 

### teat spray 

### todo-tetmine 

### If Ihe tobaoco is 

### mature enough to 

### respond to treatment with PREprw brand Ethephon. 

### Apply OVO,4h.-Iop PRE,,", brand

### Elh~~~~~ Ii"

### misl"~**~~~** nozzles (ono nozzlo lips ovO/' tho 

### oente,. I

### rl.~ so 

### a" loav•• aro cove,ed

. 

## U

...

# ~ ::' .;'.

# ~':.om

00not**~** 

### PAEPlW brand Ethophon to immaturo loavos as this can rasuh in unsatislactory coloring, weight \o$S 

### and redlJOOd leaf quality. 00 

### not allow the crop

### to over ripen In thefield 

### after using PAEprv brand Ethephon. since this may cause soma reduction in 

### ylekl and 

### quality. 00 not

### treat beforo anticipated majorstorm which could 

### provon! harvest and msu!!: in crop 

### loss. 

### Do not apply 

### PREP."M brand 

### Ethephoo**~** 

### rain is oxpClCtGd 

### within 4

### hours. APPLfCATIOH TIMING Suooossful results with PREplW call for traatmenl whon loaves are mature, no1 

### overly rank green when sprayed. To 

### easily determine the propertreatmenl11mlng and tho numborof leaves por stalk roady for harvest, tost spray several plants In more than onelocalion in 

### eachfield 

### and abselVatho response. Mature .avos

### will begin to yellow in 24

### to 72 

### hours. Test leavos that fail to

### yellow in 72 

### hours are 

### not mature and aro not ready for PREprv brand Elhophon treatment. 

### Wd a few days 

### to parmit further natural maturing, Ihen mako anothertesl spray or "maturity" check, Whon you have confirm&d tho numbor 

### 01 10avos par plant that will color, you can detarmine tho numbor of 

### actos to treat In 

### orderto lill tho barn

.


### • Preparo yourtest spray by 

### mixing one teaspoons of PAEpn! 

### In 1

### qU~rt ofwater. Spray oach test plant with about t oz. ofthis mixturo, covering an Ioavos with afine mist. PREprw: brand Ethephon will 

### nat color Immature sprayed loaves. 

### WHEN TO 

### HARVEST All 

### maturo, sprayed loaves wilt 

### begin to oolor within 24to 72 

### hours after PAEpnl brand Ethaphon appUcation, Tho yellowing

### proces.s is weathor dependanl; cool weatherwill de-lay, while hot, sunnywoather can speed up the proooss. HalVesttreated tobacco when laaves havo reached the dosired color intensity, 

### Do not allow tobaoco 10 

### becomo over ripe before starting harvost, Leaf drop can occurwhon tobacco Is over ripe and 

### left on tho stalk. 

### Ha numberofthe bottom leaves havo yollowed 

### at the 

### tirM oftraatmont. they should be harvested pOor

### to spraying with PREptIo( brand Ethephon. 

### WIth an 

### ovar-the-top application. harvesting can commence 24 

### hours aftor PREplW brand Elhophan**applicalion:«t~ng** 

### on wearhor conditions Of

### to avoid ovar 

### ripe IObaa:o, 

### Tobacco halVastod 24

### hours aftortrealmont will 

### requiro more time in tho coloring pOuooftho curing prooass. • ••••• CURING PREJ'n' 

### TREATED TOBACCO : ••:.: •••• 

### CUring procedures are 8$ 

### much an art as a scionco and each cur. must be

### judgoo on the basis 

### otto!:facto conditiof'!, intervaJ bolW09n troatment and harvest. weather and type of 

### curing facility beforo proscription temperature.m .vlnlllatp\sel1edules 

### can be estabUshad. To obtain maximum quality. car. 

### must 

### betaken to observe and control1he curing 

### proqess-eclosely, etpGCially during the late"ooloring" and 

### early .drying. stages 01 the 

### loaf. ••• •••• 

## •• PREJ»W

### brand Ethophon treatod 

### tobacco will havo startedthe coloring 

### proooS8 whon harvested, rellacthOJho time**r~** 

### in the 

### coloring 

### phaso of

### curing, Treated 

### tobaccoshould 

### bedried faster. If lobacco l&aves aro green or**CQ~aome** 

### gr80tI when haMIstod, it may be necessaryto color Ihom for 

### a low 

### hours. 

### ti theloaVCl$ are oomplotoly yollow. lemperature and vontllatltn**~** be

### adiustGd in iii 

### mannorto dry Ihe 

### tobaoco as 

### last as 

### possible without 

### scalding. Onco

### the leaf is 

### dried (314

### dry), you should**fol~"Mmai** procodUr9S 

### for coring. Since PREptw brand Ethephan troated loaVes cure faster, treated and untreated leav6s should not**~<:ur.ct**

### together in 

### the samo 

### bam.**~** 

### •••• 

# 153

# LIMITED WARRANTY AND DISCLAIMER Tho manufactuntrWaJTants 

### (al that

### thJs product

### conforms to 

### tho chemical 

### doscrfption ontho label; (b)

### that this product Is 

### reasonably lit : for the 

### purposos set forth 

### io the 

### diroctJons for use 

### whon 

### it is used in accordance with such directions; and (c) that 

### tho directions,



### warning 

### and othor statements on this fabet 

### are based UfXH1 

### responsitm experts' evaluatlon of reasonable 

## tms of effoctiveness. of IOXicltyto 

### 1aborat0f)' animala and 

### to 

### plana. and 

### of rtleldUO$ on food 

### crops and upon reports of fiold experionoo. Teats have 

### not boon 

### made on 

### all varieties Of 

### In all states or und&rallcondltkmG. 

### THE MANUFACTURER NEITHER MAKES NOR INlENOS. NOR DOES IT AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE, ANY OTHER WARRANTIES. EXPRESS OR IMPliED. AND IT 

### EXPRESSLY EXCLUDES AND DISCLAIMS ALlIMPUEDWARRANTIES OF**MERCHANT~A81l11Y**

### OR FITNESS FORAPARTICULAR PURPOSE. 

### THIS WARRANTY OOES NOT EXTEND TO, AND THE BUYER SHAll BE SOlElY RESPONSIBLE FOR, ANY AND All lOSS OR DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNERWHICH IS INCONSISTENTWITH THE LABEL DlRECTlONS, WARNINGS OR CAUTlONS. BUYER'S EXClUSIVE REMEDY AND MANUFACTIJRER'S OR SElLER'S EXCLUSIVE LlABlUTY FOR ANY AND All CLAIMS. lOSSES, DAMAGES, OR INJURIES RESUlTING FROMTHE USEOR HANDlINGOFTHIS PRODUCT, WHETHER OR NOTBASED IN CONTRACT, NEGLIGENCE smlCTlIABIlfIYIN TORTOROTHERWISE SHAllBE LIMITED, ATTHE MANUFACTURER'SOPTION, TO REPlACEMENTOF, OR THE REPAYMENTOFTHE PURCHASE PRICE 

### FDA. THE OUANTITY OF PRODUCTWITH RESPECTTO WHICH DAMAGES ARE CLAIMED. IN NO EVENTSHAllMANUFACTURER OR SEllER BE liABLE FOR SPECIAL, INDIRECTOR CONSEQUENTlAl DAMAGES RESUlTlNG FROMTHE USE OR HANOUNGOFTHIS PRODUCT. NDTlCE TO BUYER Purchase ofthis product 

### does not CQnfG( 

### any rights under patiGnts govorning Ihis product Of 

### tho use thoroof in countries outside of tho United States

.

• lDEF and Guthicn are registered trademarks of BoyarAG. Germany. 20ropp is arogistGrGdtrademarkof 

### NOR·AM Chemical Company. 3Jiarvade Is a registered trademark of Uniroyal Company.



# • 4Malathiorl is 

### atrademark of American Cyanamid Company

.

RhOne-Pouteoc

### Ala Company 

### P.O. Box 

### 12014. 2T.W, Alexander

### Drive ResearchTrianglo Park. North Carolina 

### 2n09 PREP Is tho trademark of Rh6ne-Poulenclor Ethophon CoHon Boll 

### {)panG( FOlEX 

### Is aregist&IGd tmdernark of Rh6ne·Poulonc, PREpnt brand Ethopi1on for Cotton and Tobacco (PENDING) Submitted 

### tOI23J92. 

## •••••• o 0 0 o 0 0 o 0 

## •••••• o 0 o 0



# .. •••••

o 0 o 0 

## ••••• o 0 

## •••••• o

## •••• o 0



## ••••

o o. 0 o 0 0 o
.. 

## ••• 

## • o 0



# ..
o
o
.. o 0 0



## ••••

.. 0 o 0 0 o
.. 

# 154

# 1'RE P TM 

# BRAND ETHEPHON FOR COTTON AND TOBACCO

For Commercial Use Or Agricultural Use Only" Not For Residential Use ACTIVE INGREDIENT: Elhephon (2·Chloroethyl) phosphonic acid"

........................................................55.4% INERT INGREDIENTS:

........................................................................................................................... 44.6% 

### -ThIs product contains 6 pounds elhephon pergallon. EPA Reg. No. 264-418 EPA Est. No. 264-PA-Ol 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO PRECAUCk)N AL USUARfO:Si usled no lea Ingles, no usa osto prodUdo hastll qua III informacion on la oliqueta 10 haya sido &xpJicado



### us. J I 

### i U.S. Patents ,188

# andI4:.2"4,,:.S,9. No Ilcons. 

### Is granted to usethis product J 

### otherthan tho·'··-·'"

## ·"St:''''·':.·-$or lor any use nol contemplated by this label. liability for palont infringement may rasuK from use or salo of this product outside tho United 

# titSlates. 

# STATEMENT OF PRACTICAL TREATMENT IF IN EYES: Hokl eyelids opon and flush with a gontlo stroam 01 water lor at lansl 15 minutes. Got modical attontion, proferably an 

### oph1halmoJogist. IF ON**SKlN~** ImmociiatGly wash skin wtth plunty of soap and water. Remove contaminated clothing and shoos. Wash clothing separaloly before rouse. IF

### SWAUOWED: Do

### not induce vomiting. Promptly drink a largo quantity

### of milk. 

### egg whites, gelatin solution or ilthese aro not available, drink largo quantities 01 wator. Avoid aloohoJ. CaU a physician immodiatoly. IF INHALED: Remove victim to tresh air. Ii not broathing, give artificial raspiration, Adminisler oxygen 

### if nr;cossary. Get medical altention. 

# PRECAUTIONARY STATEMENTS DANGER HAZARDS TO HUMANS AND DOMESTIC ANIMALS CORROSIVE. Causes eye and skin damago. 

### May be lataJ 

### if absorbed through 

### skin. Harmful 

### if swallowed or inhaled. Avoid broathing

• spray mist 

### Do not got in oyes, on skin oron clothing. Wear fuJilongth trDusors.long slo8vod shirt, protllCtiVA gloves, and gogglos or lace shield when handling. Change 

### to cloan workclothes daily. Wash thoroughly 

### with soap and water aftor handl1!l9 and beforo oating, orsmoking. Romovo aodwash COf'Itaminated clothing ooloro rouso. Keep away from dome-stic animals. 

### NOTE TO PHYSiCiAN Thore Is no spocific antidoto. All troatmont should be basod on observod signs and eymptoms 01 distress in tho pationl. o,.oroxposuro to materials otherthan this product may have occurroo, Victims ofsevero ovoroxposure, by inhalation, should ba kopt undor modical observation lorup to 72 hours fordelayed onsot ot pulmonary edema. In a victim ofover·exposure 

### by Ing051ion. carelul gastric I<wage is required duo to tho**possib!~** .tstomach or esophageal perforation. This material is an acid, but use01 alkaline substancos to neutralizo it Is contralndicat&ll

. 

## ENVIRONMENTAL HAZARDS 

## •••••• • 

## •• •••• • 

## •



## •••• Do notapplydirectlytowator orwetlands {swamps, bogs, marshes, and potholes}, oquipment washwaters. 

### • •• 

## • Do not contamitlalewater whp,fl dl§posing 01 

### Do not contaminate watG( used tor irrigation or domostic purposes. 

### •

## ••••• • 

## • • •



# ., ••••• USE PRECAUTIONS : : 

## •• 

## • • •• ••• • • •



## •• • ••••

## • Do not

### apply PREpn.! brand Ethophon Cotton Boll Openerthrough any 

### rypa of irrigation system. • •• 

# . , 

# . Avoid spray drift to nearby crops as this product 

### will cause modilications in plant growth, Plant injury or roducad yTdllI!

### will result. 

# " 

# . 00 not plant another crop within 30 days after Iroatman!. : •••• Mix only the amount of spray you oxpect to use each day. Do not allow mixed solution to stand overnight. 

# 155

# DIRECTIONS FOR USE It I•• vlolatlo·n of Fedora' Law to use thla product In a manner Inconslstant with Its I.betlng. Read entlr. laba' bofor. using this product. 

## REENTRY STATEMENT Mixers. loaders and applicators must WGar a lullfaco shlold. bng {rouSIlrs, long slaavod shirt. glovGS and tootsto avoid as much skin 

### and ayo oontact as possiblo. 00 nol onlor treated lields within 24 hours aftor application untoss protectNO clothing is worn.

STORAGE 

### Do not COnlaminale wator, fOOd, orlood byslorage or di$posal. 

### Ifcontainer is 

### broken 

### orcontonts have spilled, follow

## an preocautions 

### indicated above and c10an up immediately. Safore cleaning up. on full longth IroUSOffi, long steovod shirt, prot&CIivogloves, 

### and goggle.orfacs 

### shield. Soak upspUt with absorbent media such 

### sand, earth orothar suitab!o material and disposeofwastaat an approved wastedisposal fadtity.

# I~!~~~~t~! DISPOSAL 

## IF wastos are acutoly hazardous. Improperdisposal of OXCflSS pGslicldo, spray mixture, or rinsate is a violation of FOOQral law. 

# n

these wastes cannot be disposod ofby usa ac<Xlroing 

### to label instructions, contact your Slate Posticido or Environmontal ContrOl Agoncy orthe Hazardous Waste reprOS8ntativo at the nowest EPA Regional

### Offlco for guidance. 

### CONTAINER DISPOSAL equivalent) lhe empty containors. Then olfor lor 

## r and' of in a sanitary


## GENERAL INFORMATION COTTON Afoliar $pray of PREP"" brand Ethophon wlU &cc4iorala oponing 01 mature unoponod cotton bolls and onhanca defoliation which can reauR in eatlier harvaat**w~h** an incraased rocovorable yield. PREpm brand Ethaphon treatment on rotton allows Increased efficiency 

### hom a once-over haivost. TOBACCO 

### (FLUe-CURED): A foliar spray of PREPl10I brand Ethephon promotes early, uniform "yeUowing- of mature tobacco. PREp"N 

### reduces curing time, allowing more efficIent use 01 curing barn spacG, and increased control over harvest schedules. 

### SPRAY PREPARATlON Add tl2to 314 01 the requiroo amount of

### wator to the spray tank. Start agitation. Add tho requiroo amount01 PREpnt brand Ethophon. and the remaining amount 01 water. Prepareonly 

### as much spray solution 

### ascan be usGd on tho day of mixing. 

### Do oot allow spray solutlon to stand overnight Do not splH the concentrated product on spray equipmont, or any airplane parts. 

### ANVSPUSSHOULD BE RINSED IMMEDIA1aV

### WITH PLENlY OF

### WATER Use 

### of a nurso tank 

### is highly r&COmmended' for avoiding possiblo spills 

### ofconcentrated fOfmulatlon on spray oquipmont or any airplane par1s,

• COMPATIBILITY 

### PREprw brand Ethophon is rompatible with 

### DEFt, FOlE}{$, DraW, Harvade3· Methyl Parathion, Gulhian', and Malathion'\ and may 

### be appUad in sequence

# oras atank mixturo 

### (DO NOTTANK 

### MIX

# wrrn DESICCANTS 

### IF COTTON IS TO BE SPINDLE HARVESTED), In oome casos slight roductioo in boll opaning response has boon observed when tank mixoswith dofotianl.$ were used. Good agnation In tho spray tank is essontial and a tank mixturo should not 

### bo atlowad 

### to stand without agitalton for moro than 5 to to mInutes. Read and obsorve all appropriate labol use diroctions and precautions lor rhe delotianl$ and insocticides usod. NOTE: UndlH" certain**cond~ions.** tank mixtur.s of PREptw brand Ethephon with dD$k:cants containing sodium chlorate could msul( In tho formation of hypochlorous adds which on heating wiH emit toxicchloride fumes. : •••:. EQUIPMENT CLEANING • Because oltne 

### acidic nature at this product. prolonged exposure to spray doposltwilt damago**ac~lic** plastics, 

### CM1t"a.Trfpaints, and metals, ••• :.: •••• 

## • •• 

## • Rinse thoroughly with a dotergent and water all exposed acrylic plastic-typo materials (o.g.,**aircra.ftwindstlields~JlndJl4intod** surlacos within an hour ah.r exposure to spray deposits. ..:••: : •••• At the and of Nch day, rinse thoroughly with a dotergent and wator all tho metal parts ofthe alrc'aItolnd thQ

..**s~atod** spray oquipmont oxposod to tho spray deposits. ••••• • .: 

## • • •• • 

## ••••• 

# . 

# .. . , 

# .

•••• 

# .. . . , 

# . 

# . ..
156

## ---------------


# COrTON
EXPECTED PREptw 

### ONE 

## SPRAY VOLUME APPlfCATJON 

### USE CONDITIONS RATE GALLON (Gaf./A) 

### TIMfNG PREp'BI


### LBS A.I. Acr••**AI~'** PREpTIol 

### Hot and

### dry SO"For I 113 

### 1.0 6 

### Apply when the number 

# ?f Boll Optner· hIgher mafure unopenod**boUSI~:** 

### Dry and

### 75 to

### SO"F 2 1.5 4 sufficient to

### I.'i~~ 15 -50 

### 2-5 

### dO';"'<l".Cbo :
..

## _be~.~ Cool 

### but abovo

### SS"F 2213 2.0 3 lesl oj I 

### Treatmont 

### Rank cotton 

### 2213 2.0 3 baUs 710 14 days Gatlior. 

### PREPN + 

### High soU moisture 113 

### 0.25 2. 15 ·50 

### 5 ·10 

# I**~!f~!,~_I~** 7 days prfer. to 

### FOLEX· High fortllity 

### 10'101

## bO~_~_ J 

### Dolollant Tank 

### Rank cotton



### . To

# '"'I~'t. MIx 

# I**~ol ;~**  , boll PAEpnt+ Dropp:! High**so~** moisture 1i3 

### 0.25 2' 

### to -50 3*

### to Apply 4 

### to 7 days prior to 

### O.foUant Tank High fortility leyol 

### PAEpnt 

### boll opening 

### MIx To ba used as Rank cotton 

# I**~~, i~** **p~ol** , 

### boll
Pr.·CondIUoner Hot, dry, above**8O~F** 

### 213 0.5 

### 12 

# I**~Pf"t** 

# 410 7,

## d~y,**",iO'!~~** 'or Doloff.tlon Cool, above 

### 65"F "13 

### 1.0 S 15-50 

### 2·5 Rank cotton 

# I113 

### 1.0 S 

# I**~r~p,** ' 

# I**~nd ~J1ow~** of

# f~"O:a;!;':.': "Pretreatment With Delollants PrIor to PREpn.! Boll Openfng Treatment Ifthe cotton 

### is overly rank or laying down in the middle.and good spray coverage

### oJ th. bolls with PAEpnI 

### Is difficult. a prel(ealmont with defoliants

### wHi be useful to improve boll covoiago wilh PREpTIol. Use dosage rates of**PREP~** brand Ethephon Cotton BollOponor rACOmmendod for boll opening. Read and observe aU appropriate label use direclions and precautions lor the dofolianl used. "In California and Alizona usa avolume 01 no less than 5gallons per aere for aerial applications. 

### Boll MaturIty

• A boll is malure wh4n 

### it is 100 hard 

### to bedantod when squeezed talWeen thumb and lingers. too hard to be sliced with asharp**kn~o,** and when the ssed coat booome$ light brown in color, 

### Usa lImltatfons Do not exceed a maxlmum of2.0 lb. ailAforcombined uses01 PREfmI por acre per year. Boll Opening: 

### Do not tank mix PREpTl.! brand Ethophon with adesiccant if tho conon 

### is to 

### be spindle harvested. Pre-Condition lor Defoliation: Do not tank mix PREpno wilh desiccants unless plant desiccalion is required. 

### Do no! usa a deloHant before thero is sufficlont maturo unopened bolls to produce the dosired yield (see Genorallnformation sectiog on 

### Qowto lostfor boll maturity. : ••••• WHEN TO HARVEST COTTON •••• 

## • • Do not harvest co«on soonerthan 7 days after atreatmont with PAEpntbrand Ethophon Cotton**B<:Qro~aor.** • ••• Observe the troated cropand harv&st when oplimum boll opening has ixlon roachod. Too oarty haNesi

### ~ht**rop~c;**Jha tull advantage ofthe treatment and too late II: harvest may result in rGducoo quality and loss of lint which will drop

## ftOJ2'l'1t'1, plant: •••• 

### • •



# ., ••••• • • 

## • • ••••

## • ••• • ••

•• 

## • 

# · " 

# ., 

# .

••••


# . , 

# . • • 

# · "


# 157

## PREpN Crop Situation Plnta/Acr.



### ! Spray Application



### OVf(-Tho·Top Application 1113

t 

### 113 - 2 2f.3

USE LIMITATIONS 

### 50

4C-50 

# TOBACCO (Flue-Cured Only)

SpecIfic Dlrectlona drop oou!os. TG Of 

### OC designed 

### to apply 50 

### gpa at 35-40 

### psi and at traclor 01 2·3 mph. 2 nozzles per

## row: ono 00 oach side ofthe row dropped low enough

### to the spray 

### to tho leave' 

### to be ripened and harvested. Thorough

### ""'~.~'lI. is 

### oMOntiaL With a directed spray, ba sure to harvest aU

# Io;v.;,

# I

Treat only when leaves remaining on tho slalk are maturo. 

### remaining leavos are maturo, test spray soveral tobacco dG8CribGd underthe section ·Propor 11m.of Treatment."

## usa~:~~5~:~

# I

In 8 

### normally matul1I crop when oxperience indicates thai minimum Inducement is 

### required. Usotho 

### higher rate when the aopIs a tendency to be more rank or when tomporatuIlIs are lower than**':;:;~**

# I Always test spray to delarmlno 

### if tha 

### tobacco is mature enough to rc 

### 10 traatmant**w~h** 

### PREpN brand 

### Ethaphon.

Do not 

### apply PREPTIoI bl'and Elhophon 10 immalure loaves as Ihis can rewn in unsatlslactory coloring, woighllO$$ and rGdocod lea! quality. 

### Do not 

### allowtho crop 10 over

### ripon 

### in tho fiold afterusing**PRE~~**brand Elhophon, sine.lhis may causa soma rGduction in yield and quality. 

### Do

### not treat boloro anticipated majorstorm which could pr9Vent harv"1 and result in crop loss. 

### • Do 

### not apply PREPN brand Elhephoo 

### if min is ClXpoctGd within 

### 4 hOurs. APPLICATION TIMING Succo55lu! rosuU5 with PREprw. caUlor treatmont whon IeavGS are maturo, not overly rank groen when sprayed. To easily determine Ihe proper troatmomt!mill9 

### and Ihe numberof Ioavos

### per slalk ready for harvest, 1051 spray sovoral plants in morolhan one Iocalion !n 

### each field 

### and observe the 

### response. Mature loaves wWI 

### begin to yoflew in 2410 72 hours. T051 loaves Ihat lailto ye!bw 

### in 72 hours are not mature and are no! ready for PREPm brand Ethophon trealment Wait 

### a law days 

### to pormit lurthor natural maturing. than mako anothertost spray or ·maturity·chad<. Whon you havo confjrmed Ihe numoor 01leav8s par planllhal wiU color. you can dotermlno Ihe numbGr 01 acras 10 treat in order to Iii Iho bam

.

• Prepare your tosl spray by mixing onatoaspoons 

### 01 PREprw. In t quart of waler. Spray oach tost planlwith about I oz. oIlhis mixture, covoring aU loaves with 

### a line mist. PREpnt brand Ethophon will notcolor immalure sprayed loaves. WHEN TO HARVEST AU maturo. sprayed loaves wifl begin 10 colorwithin 2410 72 hours after PREf7T14 brand EthGphon appUcatloo. Tho yellowing ptOCOS$ls woather dapendent; IXlOI weather

### will delay, while 

### hot, sunnywealher can speed up tho 

### process. Harvesltrealed lobacco When leaves have reached the desired color !nlensity. Do 

### not allow tobacco 

### to bocome 

## over ripo befora slarting harvest. Leaf 

### drop can occurwhan lobacco is over riP.&: antllolt on the stalk, If a numberof Iho bottom leaves have yellowed at Ihe Ume oftrealmenl, Ihey should be harvested prior 10**spf~·wa~** PREpnt brand Elhephon. •••• With 

### an over-Ihe-top appIicalion. harvesting can commence 24 hours afler PREptw brand

### Elh~aQM:ation**·~ing** on woalhor conditions or

### to avoid over ripe tobacco. 

### Tobacoo harvostGd 24 hours aftertroalmont will roquiro npeotift%G in Iho coloring phaH01 tho curfng procoss. •• • 

## •••••• ••• CURING PREpni TREATED TOBACCO :: ••• Curing procedures are as much an 

### art as a science and each cure must bejudgod on Ihe basis 01 

### tobltx:o conll/tiOO. Ilterval betweon Iraatment and harvesl, wealher and Iypo 

### of curing tacillty before proscription lemperature "I:ftt!"t,nll!ation seltodu!es can be eslabUshed. To obtain maximum quality, 

### caro musl bo taken 10 observe and conlro! Ihe curing 

### prooesf'CIo$GIy, egpocially during Ihe tata ·ooloring· and early ·drylng· stages 

### ofthe 

### Ioal. •••• • •• 

## •• 

## • PREf7T14 brand Elhophon troalocl tobacco will hava started Iho ooloring process when harvosted. reducing**Iheljmd'~red!n** tho coloring phase 

### ofcuring. 

### Treated tobacco $hould be

### dried laslor. tllobecoo loaves ara gr

.. norcontain some**~n** tipon harvostod, it may be necessary to colorthorn lor

### a low hours. 

### If Iho leaves

### are completely yellow, lemperalure and ventilatian nMIt

### bo adjusted in 

### amanner 10 dry Ihe tobacco 

### as last 

### as possible 

### without scalding. 

### Once Iho Ioal is dried (314 dry), you shoukl 

### follow normal prOCCKluros lorcuring. Since PREpno brand Elhephon Ireated Iaavas curo laster, Ireated and untreated Ioavas should nol be cured logethor in tho samobam. 

# 158

## ------------- ---------_ ......

### - 

## --**~---**


# LIMITED WARRANTY AND DISCLAIMER .)ho manufacturerwarrants (a) Ihat Ihis 

### product conforms to Iho chemical dGwlptionon Ihe label; (b) that this product is reasonably fit

loe tho purposes sot forth in Ihe dirGCtions for usa when II is used in accordance with such directions; and (c) that tho directions, warning and other statements on this labql aro 

### based upon responsible oxperts' evaluation 

### of roasonablo losls 

### of effectlvenGSS, 

### of loxiclly 10 IaboralOlY animals and 10 plants. and of residuas on food crops and upon reports 

### at field axpotlonoo. Teats have 

### not been made on 

### aUvarioties or In all stalesor under

### all conditions. ll-IE MANUFACTURER NEmlERMAKES NOR INTENDS. NOR DOES IT AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES. EXPRESS OR IMPLIED. AND IT 

### EXPRESSLY EXCLUDES AND DISCLAIMSAll IMPLIEDWARRANTIES OF MERCHANT·ABILITYOR FITNESS FORA PARTICULAR 

### PURPOSE. TIllS WARRANTY DOES NOT EXTENO TO. AND THE BUYER SHAll BE SOlELY RESPONSIBLE FOR. ANY AND All LOSS OR DAMAGE WHICH RESULTS FROM THE USE OF THIS PROOUCT IN ANY MANNERWHICH IS INCONSISTENTWITH THE LABEL DIRECTIONS. WARNINGSOR CAUTIONS. BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, 

### LOSSES. DAMAGES.OR INJURIES RESULnNGFROM TIlE USE OR HANOUNGOFTIllS PROOUCT. WHETIlEROR NOT BASED IN CONTRACT. NEGLIGENCE. STRICT lIABIlITYIN TORTOROTIlERWISE SHAllBE LIMITED. ATTHE MANUFACTURER'S OPTION. TO REPlACEMENTOF. ORTHE REPAYMENTOFTHE PURCHASE PRICE 

### FOR, TIlEauANTlTYOF PRODUCTWITH RESFECTTO WHICH DAMAGES 

### ARE CLAIMED. IN 

### NO EVENT SHALL MANUFACTURER

### OR SEllER BE LIABLE FOR SPECIAL, INDIRECT

### OR CONSEQUENTIAL DAMAGES 

### RESULllNGFROM THE USE

### OR HANDliNGOFTHIS PAOOUCT. 

### NOTICE TO BUYER Purchase of Ihis product does not confer any righlS undor patients governing this productor Ihe use thereof in countries olilside ollhe United Slates•

• 10EF and Gulhion are regislered Uadomarks 

### of BayerAG, Garmany, 20ropp is a registered Irademark of NOR-AM ChemicaJ Company. 3Harvade is 

### a rogislerod Iradomarkof Uniroyal Company,



# • "Malathion 

### Is 

### a Irademark

### ofAmorican Cyanamid Company

.

RhOne-Poulooc

### Ao Company 

### P.O. 

### Box 12014.**~**

### T.W. Alexandor Drive Research Triangle Park, North carolina 

### 27709 PREP 

### is the trademark of Rh6no-Pouloncfor Elhophon Cotton Boii Openor FOlEX is a registered trademark 

### of RhOne·Poulel'lC

. PREprw brand Elhophon

### fO( Cotton and Tobacco (PENDING) Submittod 

### 10t23192. 

### •••••• 

# · " 

### • •• • 

## • ••••••



## • • • •



# .. ••••• 

## • • 

## • • ••••• 

## • • 

## •••••• •

## •••• 

## • •

•

### ••• • 

# .. . •• • 

# · .. ••• 

## • • •



# .. · 

# .. •• 

## •



## ••••


# .. . 

# ., 

# . 

# · .. 159

# '.

# PREP TM

# BRAND ETHEPHON FOR COTTON AND TOBACCO
For Commercial 

# Use Or Agricultural 

# Use Only. Not For Residential Use ACTIVE INGREDIENT: Ethephon (2-Chloroethyl) phosphonic acid·

........................................................55.4%



### ...............................................................................................................44.6% 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO
PRECAUClON AL USUARIO:51 ustod no lOG ingles, no use 0510 producto hasla quo In informacion on Ia allquola kI haya skh> oxplicado I

# 1fiu~



# ..**~:.:[1~~~~~~~~** USGS

# are I i 

# U.S. Patents

### ,~:24(i.ii19:, is granted to use this product in countries other than the for any 

### use not contemplated by this UabiHly for patont inlringomont may result from U$O 

### or sale of this product outside the United 

### eSlates. 

# STATEMENT OF PRACTICAL TREATMENT IF IN EYES: Hold eyolids oPGn aod flush wkh agontlo stream 01 waler lor

### at least 15 minutes. Gel medical attention, prolorably an ophthalmologist. IF ON SKIN: Immediatelywash skin with plenty 

### of soap and walor. Ramovo contaminated clothing and shoos. Wash clothing separately before rOUM. IF SWALLOWED: Do 

### not indllOG vomiting. Promptly drink a largo quantity of milk. 

### egg 

### whit". gelatin solution or if these aro not 3ValJab{o, drink large quantities. ofwater. Avoid alcohol. Call a physician immediately. IF INHALED: Remove victim to fresh air. Hnot breathing, give artilicial rospilation. Administer oxygen if necossary. Got medical allanlion. 

# PRECAUTIONARY STATEMENTS DANGER HAZARDS TO HUMANS AND DOMESTIC ANIMALS

• CORROSIVE. Causes eye and skin damage. May

### befatal ifabsorbed through skin. Harmful ifswallowed orinhaled. Avoid breathing spray mist. Do not get In eyes, on skin Ofon clothing. Wearfu!llength trou&ers, long sleeved shirt, protective gloves, and gogglos. or faco shi-'dwhen handling. Chango to clean 

### workclothes daily. Wuhthoroughly with soap and waterafter handling and before oaling, orsmoking. Romovo and wash contaminated clothing beforo reuse. Keep away from domestic animals. NOTE TO PHySICIAN There 

### Is 00 specificantidote. An troatment should bebased on obsorved signs and symptoms of distross in the pation!. Ovoloxposuro to materials otherthan 1his plOduct may have occurred. Vidims 

### of severe overexposure, by inhalation. should be kept under medical observation lorup to 72 hoUrs for dolayGd onset 01 pulmonal)' od&mB. In avictim of**ovef~axposuro** by Ingestion. careful gaslric lavage Is required due to the possibfllY.QCllfOmach or**.~al** perforation. This matelial 

### is an acid, but use ofalkaline substances 10 neutralize 

### It Is CXlntralndicated

. 

### •••• • • 

## ENVIRONMENTAL HAZARDS :•• :.: •••• Do not 

### apply directlyto water orwetlands (swamps, bogs, marshes, and potholes). Do not contamirCatewl6erwhen disposing 01 aqulpment washwalers:, •••••• :...• 

## •• ••• • • 00 not contaminate wator used for irrigation ordomestic purpoSGs. 

## •• ••••• 

## USE PRECAUTIONS 

## • • 

## • • 00 oot apply PREP"' brand Ethophon Conan BoU Op&northrough any typo oIlrrlgation system. 

### ••••• 

# .... 

# . • 

## •

•• • • 

## •• •• • Avoid spray drift

### to nearby crops a5 this ploduct

### wiU cause modifications in plant growth. Plant injury or roducGd ylulct.

### will resul!. 

### 00 not plant anothercrop within 30 days aftGrtreal:monl. Mix only lho amount of spray you expect to use each day. 

### Do not allow mixed sojU1ion to $land overn)gh1. 

### •• 

## • •• • • ••


# 160

# r

...**~**...

### -

...

# --------------------

DIRECTIONS FOR USE II '0 a vlol.tlon of Fodo,,1 Law 

### to UN this product In • manner Inconslslanl with 118 labeling. R

••d Gnltre label before using this product. 

## REENTRY STATEMENT Mhc8t"$, loaders and applicators must wear a full face shield, 

### long ltousors. long sleoved shirt, glovos and boots to avoid as much skin and 

### oya contact as pouiblo. 

### Do not enter Irea100 fiolds Within 24hours after application unloos protectiveclothing 

### is worn.

not 

### contaminato water, food, 

### orfeed by storage ordisposal. 

### oonlaine( is broken orcontents have spilled, 

### follow aU precautions indicated above and ckaan up 

### immediately. Baforo deaning 

### up, full length fIOUsers, long

### sloeved shirt. protectivo gloves, and goggles orface shield. Soak 

### up &pill 

### with absorbent 

### media such sand, 

### earth orothersuitable material and disposeof

### wast. at an approved waste 

### disposalfacility. DISPOSAL hazardous. Improperdisposal ofexcess pesticide. spray mixture, or rinsalo is 

### aviolation 01 Fooerallaw. of 

### by UNaccording

### to labol instructioos, contact your Stat. Pesticide or Environmental Control r&p10&8nlativo at the nearest EPA Regional Offlce for guidanc..



## GENERAL INFORMATION COTTON 0' 

### and dispose 01 

### in asanitary

Afoliar spray 01 

### PREpn! brand Ethephon will 

### acx:ol«ate oponing of maturo unopened cotton bolls and 

### enhance dolollation which can 

### result mearlior 

### harv84twith an increuod 

### recoverable yield. PREPlW 

### brand Ethephon trealment on cotton alkrws increased effICiency lrom aonoct-over harvest. TOBACCO (FLUe·CURED): A foliar spray of PREpt>I brand Ethephon promotes early, unilorm**"yellowing~** 

### of mature tobacco. PREPni reducos

### curing time, allowing more efliciont USfi 

### ofcuring barnspace, 

### and increased conlrol over harvest schedules. SPRAY PREPARATION Add 

### 112to 

### 3/4of1ha 

### required amount 01 

### waterto the spray tank. Slart agitation. Add tho required amount of PREpnor brand Ethophon, aod Ihe remaining amount ofwatOJ'. Prepare only as much spray solution as can be 

### used on the day of mixing. Do not allow 

### spray -solution to stand overnight. Do not

### spill tho concentrated product on spray equlpmenl, or any airplane parts.

_ SPilLS SHOULD BE RINSED IMMEDIATELYWITH PLEmYOFWATER. U&&01 

### a nurn.tank is 

### highly recommended for avoiding possible spills 01 

### concentrated formulation on spray equipment or any airplano

• parts. COMPATIBILITY PREPnI brand Ethophon is compatible with 

### DEFt, FOLE)C?I, 

### Dr0pp2, Hatvado3
, 

### Methyl Parathion, Guthlon

### t, and Malathion-'l, and 

### maybe 

### applied Insoquooeooras a

### tank mixturo (DO

### NOTTANK MIX WITH DESICCANTS IFCOTTON IS TO BE SPiNDLE HARVESiEDJ. In 

### somecases alight reduction in 

### boll opening rosponse has been observed when tank mixes with defoliants wore used. Good 

### agitation in tho spray tank is 

### os"nll&1 and atank mlxturo should not be 

### allowed to 

### stand without agitation tor mora 1han 5to 10 minutos. Read and 

### observo all appropriate !abo! 

### use directions and 

### precautions for the defoliants and insOdicides used. NOTE: Underoortain conditions. tank mixtures of PREP'n' brand EthGphon with desiccants containing sodium chlorate could result in the formation of hypochlorous acids which on heating will emit toxicchloride tumes. • • 

## •••••• EQUIPMENT CLEANING • Becauso oltho acidic 

### nature ofthis product, prolonged 8xposure to spray deposit will damage acrylic piastics, c,t\IIIfI,pamts. and metals. : ••:.: •••• Rinse thoroughly with adetergent and watar all oxposod acrylic plastic-typo materials (e.g., aircndi wtndshleIdS}. arld painted surlaces wHhln an hour after exposure to spray deposits. •••••• • •••• 

## •• 

## ••• At the end of oach day, rinse Ihoroughly with a detergent and watar all the mota! 

### parts- of the airdt,#'Md**lhI..s~atod** 

### spray equipment exposed to the spray doposi1s. ••••• • .: 

## • • " 

# . ••••• • 

## •• 

# ., 

# . •••• 

# . , 

# . •• • 

## • ••


# 161

# ,--- , ...

## _--- 

# ._ ........

## _.--_. 

# __ . 

### ---_.



## COTTON

EXPECTED PREpm 

### ONE SPRAY VOLUME 

### APPliCATION USE CONDITIONS RATE GALLON (Gala/A) TIMING 

# r:.EiT":.
LBS A.I. 

### Acr•• 

# A,..· PREpm 

### Hot and dry**~F**

### or 11/3 1.0 6 Apply when the number of Boll Oponer" higher mature unopened bolls Is Dry

### and 75to 8O-F 

### 2 1.5 4 t5·50 

### 2·5 sufficient to produce the dosirod crop. See 

### below lor Coolbut above**65~F** 

### 22/3 2.0 3 test 

### 01 boll maturity. Treatment unilorm!y opens 

### Rank cotton 

### 22/3 2.0 3 bolls 7to 14 daysearlier. PREP

... High 

### soU moisture 

### 1/3 0.25 2. 15**~** 

### 50 

### 5· to 

### Apply 4 to 7 days prior to 

### FOLEX· High lertllity level PREpN boll opening OafoHant Tank Rank cotton application. To 

### be used as



### Mix a S;u;I::ltreatmem wilh, not in of PREpnc boll PREpn.t+ Oropp2 High

### soW moisture 

### tl3 0.25 

### 2. 10·50 3· to Apply 

### 4 to 7 days prior to Defoliant Tank High lorlility Iovel PREpnI boll opening To be used 

### as Mix Rank cotton

,

# ~ot**i~ PI~** .0' with, 

### boll

Pro-Condllloner Hot, dry, above**80~F** 

### 2/3 0.5 12 Apply 

### 4 to 7 daY' prior to 

### lor Dafollallon 

### Cool•

## .wove**65~F** 

### 11/3 1.0 6 15·50 

### 2·5 defoliant. Enhances
__**!o~** Rank cotton 

### 11/3 1.0 6 crop dalollation 

### i delerioration of bottom crop 

### sod allows 

### '0' earlier


### ·Pretreatment WHh Defoliants Prior to PREPTloI Boll Opening Treatment Ifthe cotton is overly rankor laying down in the mIddle. and good spray coverage 01 tho bollswith PREpm 

### Is difficult, 

### a pretraatment with dofoHants will be usaful to improve boll coverage with PREPN. Use dosage rates

### ot PREpn.t brand Ethophon Cotton BollOpenor rGCOmmondad tor boll opening. Road

### and observe all appropriate labol use diredions and precautions tortho defoliant 

### usoo. "InCalifornia and Arizona uso avolume 01 no less than 5 gallons- per acre for aerial applications. 

### Boll MatUrily

. 

# til Abolt

### is mature wh9tl it is too hard to 

### bedentedwhen squoozod ootwG9tl thumb 

### and tlngers, 100 hard tobe sliced with 

### asharp knife, and when the

### seed coat becomes light brown in color. 

### Usa Llmltallona Do nat exceod a maximum ot2.0 lb. ai/Atorcombined usosot PREpm pol'acro par yoar. Boll Opening: 

### 00 not tank mix PREp-n.t brand Ethephon with a dosiccant if tho cotton 

### is to be spindle harvestOO. Pro.condltion tor Deloliation: 

### Do not tank 

### mix PREpn.t with desiccants unless plant desiccation Is required. 

### Do not uso 

### a dofoliant before there issufficient mature unopenod bollsto producathe dosiredyield (500 Gonerallntormation soctiOll on 

## gow to tost for boll maturity. :

..... WHEN 

### TO HARVEST COrrON •••• 

## • • Do not harvest cotton sooner than 7 days after a troatman! with PREpm brand Ethephon Cotton**B4lr~bor.** • ••• 

# .**~.** 

# . Observe tho treated

### cropand harvGst whon optimum boll opening has boon reached. Too early ha!VO$t might re,.duco the fuR advantage 

### ofthe treatment andtoo Jato a harvast may result In roducod quality and lass otlint which

## wm drop

### Q~)he plantt •• •• 

# ... 

# ... • 

## •

•• •••• • 

## • ••••• •• 

## • • •• • 

# ....**~** 

## • •• 

## •• •



## •••• •• 

## • • • • 

## ••


# 162

# '.

PREpTiol 

### Crop SIIU1ulon Plnt8/Acr.


### Olrectod Spray Application



### Ovor.Tho-Top Application \1/3



### 1113-2213

USE LtMITATtONS 60-60

40-60 

# tosACCO (Flue-Cured Only)

Spoclflc Olractlona
Use drop noWos. Choose OfOC spray dosigned 

### to applY 50 

### gpll 

### at 35-40 

### psi 

### and at tractor 

### sp.ed of 

### 2·3 mph. 

### 2 nozzlGs per 

### row; ono on 

### oach 

### sid.oftho row dropped

# ~::~~:~i;~::

# I
tho ,pray to tho loaves to 

### be ript:nod and harvested. is 

### er.sGnlial. With a directed spray, be 

### sur.to harvost
Troat only when loaves romaining on the $Ialk are maluro. To 

### romainlng loavo. are mature, lest spray .ovaral tobacco plants doscribod unde,tho SGQion 

### ·ProperTIme ofTreatment**~** 

### Usa tho lower in a normally mature crop when experience indicates that minimum

### rip<!~;'1Q

# I IndllCGment is 

### required. Usoth. 

### higher rate whon tho crop is heavy a tendency to 

### be more rank or wn.n tomperaturos**~u.** Iowar than**':::~**

# I Always tosl spray to determino 

### if tho 

### tobacoo is 

### mature onough 

### to rI 

### to troatment

### with PREpN brand Ethophon.



### Do not apply 

### PREpn! brand Eth.phon to immature loaVO$ 8$

### this can result In unsatistactory coloring, weight loss and roducod loaf 

### quality. 00 not allow the crop

### to over ripon in tho Iklld after using PAEpn.c brand Ethephon, sinee this may cause some reduction in yield and quality. 00 nottmat belam anticipated majorstorm wnk::h couk! prevent harvest and rosult in crop loss. 

### • Do not apply 

### PREpN brand Ethept;on if 

### rain is expoctod within 4 houtS. APPLICATION TlMtNG Successful results with PREplW call for treatment whon leaves are 

### mature, 

### not overly rank green when sprayed. To easily detormino the proper troatment timing and the number 01108vO$

### per stalk ready for harvest, test spray severat plants 

### [n more than one location in each field and cbselVothe respons-e. Ma!ureloavoswill begin to yellow in 24 to 72 hours. Test loaves that fail 

### to yellow 

### In 72 hours are not 

### mature and are not ready for PAEpnt brand Ethophon treatment. Wait afew days 

### to permit further natural maturing, then mako anothertest spray or**~rnaturity·** 

### chock

.

• When you have confirmed th8 numberof loaves per plant that will color. you can determine the numhAr of acres to treat in order to tijl he barn. Prepare yourtest spray by 

### mixing ana toaspoons of PAEpTiol in 1quart of water. Spray each tast plantwith about 

### t 

## oz. of this mixture, covoring 

### aU lGaves with a line mist. PAEpn.! brand Ethephon will notcolor immature sprayed leaves. WHEN TO HARVEST 

### All mature. sprayed loaves wWl begin to rolor within 24 to 72 hours after PAEprw brand Ethephon application. Tho yellowing procos.s is 

### weather dependent; cool weatherwill delay. while hoi, 

### sunnyweathGrcan spood up the procoss. Harvosttroated tobacco whon loaves have roached the doolred color intensity. Do not allow tobacco to become over ripe beforo starting 

### harvost. Loafdrop can occur when 

### tobacco is over**r~lftft** 

### on tho stalk. If a numberof tha bot1om loaves havo yellow&!! at the timo of troatmant, thoy should be harvested priorto sprayittg with PAEPN brand Ethaphon. ,."', With an ovar-the-top application, harvesting can commonce 24 hours after PAEpn.! brand**Eth~ 'l~** **d~~ng** 

### on waathor conditions or

### to avoid over ripe tobacco. Tobacco harvested 24 hours aftertreatment will 

### raquire**mare~'"** 

### in the cobring phasa at tho curing process. ",.,' :',', CURING PREptW TREATED TOBACCO :: 

## '<II" Curing procedures tile as much an art as ascience and each cure must be judged on tha basis oftotJCco 

### roodlMIt, i;terval botwoon treatment and harvest, weather and type 

### of curing facilil}' before prescription temperature**a~'~/Wltilatlon** 

### sc'h'edulos can be established. To obtain 

### maximum quality, care must bo 

### taken to observe and control tho curing**p_.~**

### t:IoSGIy, esf,locially during tho lata 

### ·0010009" and 

### eally '"drying" stagas of tho !eat : , ••• 

## •••• PAEpm brand 

### Ethephon treated tobacco

### win have started tho oolodng process when harvested, reducing the tlmueqVired inthe coloring phase ofcuring. Troatod 

### tobacco should be dried fastor. II tobacco teaves aregreen orcontain some gllGOf'l Mon harvostod. it

### may be nocosearytocolorthem for afow hours. Iftho \aavOtl are oompletety yellow. temperature and VGn1.Uatio'n 

### mMt be 

### adjustad in amanner 10 dry the tobacco as fast as possible without

### scalding. Oncethe lem is 

### dried (314 dry). you should follow normal procedures for curing. Since pREfN brand Ethophon troated !eaves cure fastor. troated and untroatod loaves should not be

### cured together 

### in tho sema barn. 

# 163

### •**.~---.------**



# LIMITED WARRANTY AND DISCLAIMER ,:;he manufacturorwarrants (a) 

### thatthis 

### product conforms to Iho chemical description on the label; (b) that this 

### product is reasonably fft for the purposos sot forth in tho directions for ute whon 

### it is used in accordance with such directions; and (c) that Ih. 

### directions. waming and other statemenls on this label are basod upon responsible experts' eValuation 

### of reasonable tasts 

### at effectiveneas, of toxicity

### to laboratory animals and to 

### p\ants. and of tftGlduos on food crops and upon reports 

### of lleld experience. 

### rests have 

### not boen 

### made on allvarieties or in all states or underall condKions. THE MANUFACTURER NEITHER MAKES NOR INTENDS. NOR DOES IT AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES, EXPRESS OR IMPLIED. AND IT 

### EXPRESSLY EXCLUDES AND DISCLAIMS AlLIMPLIEDWARRANTIES OF MERCHANT·ABIlITYOR FnNESS FORA PAR11CUlAR PURPOSE. THIS WARRANTY DOES NOT EXlEND TO, AND THE BUYER SHAll BE SOlELY RESPONSIBLE FOR, ANY AND All LOSS OR DAMAGE WHtcH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENTWITH THE LABEL DIRECTIONS. WARNINGS OR CAUTONS. BUYeR'S EXClUSIVE REMEDY 

### AND MANUFACTURER'S 

### OR SelLER'S EXCLUSIVE LIABILITY 

### FOR ANY AND ALL CLAIMS, 

### LOSSES, DAMAGES, OR INJURIES RESULTING FROMTHE USE ORHANOUNGOf'THIS PRODUCT, WHETHEROR NOT BASED IN CONTRACT, NEGlIGENCE. STRICTLIABILITY IN mATOR OTHERWISE SHAllBE LIMITED, ATTHE MANUFACTURER'SOPTION, m REPlACEMENTOf', OR THE REPAYMENTOFTHE PURCHASE PRICE FOR, THEQUANTfTY OF PROOUCTWITH RESPECTTO 

### WHICH DAMAGES ARE CLAIMED. 

### IN NO EVENTSHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, INDIRECTOR 

### CONSEOUENTlAl DAMAGES RESUlTING FROMTHE USE OR HANDLINGOFTHIS PRODUCT, NOTICE TO BUYER Purchase of Ihls product doos not canfor 

### any rights under palients governing this product orthe use therlKll in 

### countries outside of tho United Siaies. 

# e lDEF and Guthlon are registered Irnd&marks of 

### BayerAG, Germany. 2Dropp is a rogistarad tradamatk of NOR·AM Chomicat Company. 3HlUVadO 

### Is a rogistarod tradomark of Uniroyal Company.



# • 4Malathion is 

### atrademark of

### American Cyanamid Company

.

Rh6n.Pou!enc Ag 

### Company P.O. Box 12014. 2 T.W. AJoxaodof Drive Ros&arch Triangle Park. North Carolina 

### 2nog PREP is 

### the trademark of 

### RhOne-Poulenc for Eth&phon Cotlon 

### BoH Oponor FOLEX 

### Is a registered trademark of 

### RM/'lo-Poulenc. PREpni brand Ethophon for Cotton and Tobacco (PENDING) Submitt&d 10123192. 

## ••

## •••• • •• 

## • •• 

## • • •••••• • 

## • • 

## •

•• •••

## •• • • 

## • 

## • ••••• • • •••••• ••••• • •



## •••• •


# ., 

# . ., 

# . • 

## •• ••• • • •

•• • 

# · " 

## •• 

## •



# ......
., 

# . • • • •• 

# 164

# ,PREP TM

# BRAND ETHEPHON FOR COTTON AND TOBACCO
For Co";merclal Use Or Agricultural Usa Only. Not For Residential Use ACTIVE INGREDIENT: Elhephon (2·Chloroethyl) phosphonie acid·

........................................................55-4% INERT INGREDIENTS:

...........................................................................................................................44.6%**~This**

## product contains 6 pounds ethephon pergallon. EPA Reg. No. 264-418 EPA Est. No. 264-PA-01 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO
PRECAUCk>H AL USUARIO: 81 uslod no loe ingles, no use este producto haslll qUG 10 intormacion en 18 oliqUGta Ie haya 500 explicado

uSGS ale U,S. ,188

### andj-4:24·C~

# .•,9: license is granted to

# us. this product in countries otherthan tho 

### lor any use not contemplated by this I Liability lor patont infringomont may result from usa or salo of this product outside tho United 

### _SlmIGS. 

# STATEMENT OF PRACTICAL TREATMENT IF IN EVES: Hold eyelids open and flush**w~h** agontlo stroam of walorfor 

### at loast 15 minutes. Gol modical atlantion, preferably an ophthalmologist. IFON SKIN: Immodiatoly Wll$h skin with plonty 01 soapand water. Remove contaminated clothing and shoes. Wash clothing separately before rouse. IFSWALLOWED: Do not induce vomiting. Promptly drink a large quantity of milk, 

### egg whilos, gelatin solution or iftheso are not available. drink largo quantities ofwater, Avoid alcohol. Calla physician rmmediately. IF INHALED: Remove victim to fresh air. 

### If not breathing, give artificial respiration. Administer oxygen if nocessary. Get mooical attention. 

# PRECAUTIONARY STATEMENTS DANGER HAZARDS TO HUMANS AND DOMESTIC ANIMALS CORROSIVE. Causes eyo and skin damage. 

### May bG fatal ifabsorbed through skin. Harmful Ifswallowed or inhaled. Avoid breathing



### • spray mist. Do

### not got In OVas, on skin oron

### clothing. Woarfull length trousers, long sleevoo shirt, prol&CIive gloves, andgogglos or face shield whon handling. Changeto clean

### work dothes dally. Wash thoroughly with 

### soap and wator

### altar handling and before eating, orsmoking. Remove and wash comaminated clothing boloro reuse. Koop away from domestic animals. NOTE TO PHYSICIAN Thera is no specific antidote. AU treatment shouldbo basad on abselVed signs and symptoms of distress in tho patient Overoxposure to material;otherthan this product may have occurred. Victims ofsevere overexposurG, by inhalation, should be kept undor medical observation lorup to 72 hours for delayed onset of pulmonary odema. In a victim ofover-exposure by ingtl$tion, carelul gastric lavage is required due tothe possibHity ofstomach or esophageal perforation. This material is an acid, but use ofalkaline substances to**neutra~ze** it isoontraindicated. 

## ENVIRONMENTAL HAZARDS 00 not 

### apply directlyto water orwOllands (swamps, bogs, marshes, and pothoios). aquipmentwashwatel'S. 

### Do not oontaminate water usoofor irrigatkln ordomestic ptJrposos. 

## USE PRECAUTIONS 

# • • •••••• • Do not oontaminatewatorwllptl-di!QOsing 01 

## •••••• • 

## •• 

# • •• 

## • • 

## ••••••

• 

## • • 

## • ••••


## •• • 

## •• 

## • • 

## •• •• •••• Do oot apply PREPw brand Ethophon Cotto;') Boll Openerthrough any

### typo of irrigation system. ••••• • .: Avoid spray drift 10 nearby crops asthis productwill caUSe mooilications in plant growth. Plant iniu"/.

### dr re21ucod yiolGis 

### wiD resull. 

### •••• 00 not plant anothercropwithin 30 days aftertreatmont. Mix only Urn amount ofsprayyou oxpectto use aachday. 

### Do not allow mixod solution to stand ovornight 

## • •• 

## •• •

•••• •• • 

# •• • 

# · '. 

# 165" 

# DIRECTIONS FOR USE It 

### 18 • violation ot 

### Fedoral Law 

### to use this product In a manner Inconalatant with Its labeling. 

### Road entlr. labo' bafor. usIng thIs product. 

## REENTRY STATEMENT Mixers, loaders 

### and applicators mustwoar a fuH face shield, 

### long trou$Ors, 

### long sloevud shirt, glovos and**~ots** to avoid as much skin 

### and eye contact as possible. 00 not 

### entertmmGd fiGlds within 24 hours after application unless protoctive clothing is worn.

# 1~!~~~"'~~n~laminat. water, food, 

### or food by 

### storageordisposal

containor 

### is brokon oreontanls have spilled, lolk>w aU precautions 

### indlcatod abovo and clean up immediately. Before cleaning up, 

### fuU length trousers, 

### long slhvod shirt. protective gloves. and goggles or face shield. 

### Soak up spill with absorbent media such sand, earth orothersuitable material and 

### dispose 01 

### wast. at an approved wast. disposal facility.

# '~:;.~~:~~II~;, 

# DISPOSAL I! wastes areacutely hazaIdous. Improperdisposal 01 excess pesticide, spray m!xturo. or rinsate is a violation 01 Fodorallaw.

those wastes cannot be disposed of by use acoording 

### to label instructions, contact your

### Stahl Pesticide or Environmontal Control 

# I**~~~~,~~th:~e**HazardousWaste reprosentative atth8 nearest EPA Regional Office lorguidance. 

# L DISPOSAL tho ampty containers. Thon ollor lor Ii 01 in 

### a sanitary i i 

## GENERAL INFORMATION COTTON Afoliarspray 

### of**PREP~** brand Ethophon will acotIarateopGning of mature unopened cotton bolls and enhanco dalol;ation which 

### can result in oatNar harvGst with an increased r&coverable 

### yiold. PREpTW brand Ethophon troalment on cotton allows increased efficiency lrom-a once-over harvest. TOBACCO {FLUE.CURED): A loliar spcay 01 PAEpnc brand Ethephon promotes early, uniform**"yellowing~** 01 mature tobacco. PREpnc reduces curing time, allowing mora officiant usa 01 curing barn 

### space, and increased control over harvostschedules. SPRAY PREPARATION Add 

### 11210 3/4 

### oftho required amount ofWaler

### tothe spray tank. Start agitation, Add tho required amount01 PREPno brand Ethophon, and the remaining amount ofwator, Prepare only as much spray solution as can 

### be uSGd on tho day of mixing. Do notallow splay solution to stand overnight. 

### 00 not 

### spiU tho concontratod product on spray**equipm~nt,** or any airplane parts. 

### ANY SPILlSSHOULD BE 

### RINSED 

### IMMEDIATELY WITH PLENTY

### OF

### WATER Use 01 a nurse 

### tank is highly recommondod for avoiding possible spilla ofconcentrated fOfmulation on spray oquipmant orany airplane parts•

• COMPATIBILITY

. PREP'"'

### brand Ethophon is compatible with DEFt,

### FOLEX'*, Draw. Harvoo03
, Mathy! Parathion, Guthion 1

, and Malathion', and may 

### be appfiod in SGqUGtlCO or

### asatank mbctute 

### (DO NOT

### TANKMIX Willi DESICCANTS 

### F COTTON 

### ISTO BE SPINDLE HARVESTED). In some

### casos slight reduction in boll opening responae has 

### boon observedwhen lank mixoswith dololiantswine used. 

### Good agitation in tho sPfay tank is ouontiat and a tank mixture should not be 

### allowed 

### to sland without agitation for more than 

### 5 to 

### 10 minutos. Read and observo all appropriate tabol 

### usa dirOdions and precautions lorthe defoliants and insecticides used. NOTE: 

### Under cartain conditions, tank mixtures 01 PREpnt brand Ethophon with d05iocants containing sodiUm chlorate oould rasult in the formation ot hypochlorous acids which on heating will omittoxic chloride lumes. EQUIPMENT CLEANING BDCtIuse 01 the acidic natura ot this product. prolonged oxposure to spray dopositwill damage acrylic plastics. CfLtfWo:Q4ints. and metals, • Rim.thoroughly with a detergent 

### and wOller all exposod acrylic plaslic·typo matorials (o.g., aircraftwindshiolds).I:M1::wtlntod surfacos wfthln an hour altar exposure to spray deposits. : ••:.: •••• Attho end of

### each day, rinse thoroughly with a dotergent and watar aU the motal parts oftho**aifcra~** and the asSociated spray oquipment oxposed totho spray deposits. •••••• :...• 

### •• 

## ••• 

## • •



# .. •••

## •• 

## • • • 

### • 

### ••••• 

## ••• 

## • • •



# .. •



# . .. 

# . , 

# . •••• 

# .. . •• • 

# ... 166

## COTTON
EXPECTED PREp1loI 

### ONE SPRAY VOLUME 

### APPLICATION USE CONDITIONS 

### RATE GALLON (Gala/A) TIMING PREPO(
LOS A.1. 

### Acr

.. Air·· 

### PREpm Hot 

### and 

### dry 8O"'F Of 

### 1113 1.0 6 Apply when the numbor

# ?f Boll Oponer" higher 

### mature unopened bolls,. is Dry and 75 

### to IWF 

### 2 1.5 

# • 15 ·50 

### 2·5 sufficient to

# P~d=~~~~ desired crop. SIIG Cool but above

### SS-F 2213 2.0 3 

### test of boll**~'!.** 

### 2213 

### Treatment**~~oris** Rank cotton 

### 2.0 3 

### bolls 7

### to

. PREpni 

### + 

### High**so~** moisture 

### 113 0.25 2. 15 ·50 5 -10 Apply 4 

### to 7 days**Pfjo~** to 

## FOLEX" High fertility level 

### PAEpnl boll opening Defoliant 

### rank Rank cotIon 

### ."",leallco. To bo

### US~,5 

### Mix a- treatment 

### 001

# in plac. of PRE,,", PREpnf+ Droppz High $Oil moj!llur9 

### 113 0.25 

### 2' 10

- 50 

### 3·10 

### Apply'" to 7 days**prio~** 

### to Oofollant Tank High 

### fortility lavol 

### PAEpnI boll j



### Mix Rank cotton 

### application. To be**UUd.~s** 

### eo

# SO~U:I=lr8atm8n~w:i not in of PAEPTM


### Pre-Conditioner 

### Hot, dry, 

### 213 0.5 12 Apply 4 to 7 days prior. to 

### for DefOliation 

### Cool, above 

### 65°F 

### 1113 1.0 6 

### 15 ·50 

### 2·5 delolian!. Enhances top 

### crop defoliation reducing 

### Rank collon 1113 1.0 6 dolorioration 

### of**bot1om~~,r~** 

### and allows for I


### ·Pretreatment With Defoliants Prior to PREptloI Boll Opening Treatment If

### tho cotton isoverly 

### rank or laying down 

### mtho middt..and good spray coverage oftho bolls with PAEptw is difficult, a pretreatment with defoliants

# wi. be usafulto improve boll covarage with PAEpm. Use dosage talos of 

### PREP'"" brand Ethophon Cotton BoU 

### Oponer tOCOmmondGd for boll opening. Road and observe all appropriate iabol use directions and PfOCQutlons fortho defoliant used. 

### ·-In CaliforniaandArizona use a volume 01 no loss than 5 gallons poT 

### acrefor aerial applications. 

### Boll Maturity

• A boB is maturewhen 

### it is too hard 

### to be donted when squoezed between thumb and lingOTS, too hrud 

### to be sliood with asharp knife, and 

### when the seod coat becomes light brown in color. 

### Use LlmbatioRs • Do not oxeo&d a maximum of2.0 Ib, aiJAforcombined uses

### 01 PAEPN peracro poryear. BoU 

### Opening: 00

### not tank mix PREpllI brand Ethophon with a desiccant 

### iftho cotton is to ba spindte harvested, Pre·Condition for Defoliation; Do not tank mix PREPnI with desiccants unloss plantdosiccation 

### Is required, 

### 00 not use 

### a defoliant bafore thore is sufficient maturo unopened boilsto produce tho desired yiekl {seo Genera! Inlormation section on how

### to tostfor bol! maturity. 

### WHEN TO HARVEST COTTON 

### • • 

## •••••• Do not harvest cotton soonerthan 7 daysaftera treatment with PAEpnt brand Ethephon Cotton Boll Opener. • Observethe treated crop and harvostwhon optimum bol! oPfining has 

### boon reached. Too earty harvest might roIilM.t!liG lulladvantage 01 the troatmont andtoo late a harvest may result in roduct.ld quality and loss of lint whichwijl drop

## ftdlfl)no plant···· 

### • •• • 

## • • •••••• 

## • • • •

•• 

### ••••• 

## • • • • 

### ••••• 

## •• • •• • • •• ••• • • 

## •

•• • • •• 

## •• •

•••• 

## •• • •• 

## • • •• 

# 167

### PREpTW Crop Situation Plnt./Acr.
Otroct&d Spray Application

Over-Tho-Top Application 

### 11/3

11/3-22/3

USE 

### LIMITATIONS 

### 40-60 

# TOBACCO (Flue-Cured Only)

Spoclftc DIrections
U&o drop rtOnJo.. Choo" TG or DC spray tips designtrl

### to apply 50 

### 3540 

### psi and at tractor speed of**2~3** 

### mph. 

# I**~nazzh".I>..,** on each side ofthe 

### rowdropped

# ~::j~:~~~J!~::

# I
to 

### be ripened and harvosted

. • dirocted 

### spray, be 

### sur. 10 harvest 

### only when leaves remaining on tho stalk aro maturo. To romaining loaves are mature, tost spray several tobacco plants d9SClibed underthe section ·Proper11m.of

### Treatment- Usa tho lower in a normally mature crop when experience indicates 

### that minimum I 

### inducament Is required. Usa1ho higher rate whon tho crop is heavy 

### and has a tendency to be more rank or when temperatures are lower than normal. 

### Always last spray to 

### determine if the tobacco is 

### mature enough to respond 

### 10 treatment 

### with PREprw brand Ethephon. Apply over-tho-top PREpni brand Ethephon spray as a1ino mist nozzles 

### (ono nozzle tips over the cootorof the plant, 

### and $0 

### aJl leavos are 

### covered similar to the I

00 

### not apply 

### PREpn.fbnlnd Ethephor:!o immature loa

....5 as 

### this can result in unsatisfactory coloring, weight loss and 

### redUCiKlloat 

### quality. " 00 

### oot allow the crop

### to over ripon in 

### the field 

### after using PREP'"" brand Ethephon. since 

### this may cause somo roduction In yiGld and 

### quality. 

### Do not treat before anticipatGd maprstorm which could prevent harvest and result in crop 

### loss. 00 not 

### apply PREpDI brand Ethophon ifrain is expoc1od within 4 

### hours. 

### APPLICATION TIMING SUCC8Ssful results with PREPN call 

### for treatment when loaves are malure, not overly rank green whon sprayed. To easUy determine Ihe 

### propor uoalmont liming and tho numborof leaves por stalk ready 10r harvost, test spray several 

### plants In mora than one klcation in each 

### flGld and oburvetho rlMponso. Maturo !envos 

### will begin to yellow in 

### 24 

### to 72 hours. Tost!eavosthat fail 

### to yellow In 

### 72 hours Me not matura and are 

### not ready for PREpTW brand Ethephon troatmon\. Walt a fow days 

### to pGrmlt further natural maturing, then mako anothertest spray or -maturity- check. When you have conflrmod the numbor of 

### leaves per plant that will color, you can detarmine tho numbo! 01 acros to traal in 

### orderto fill Ihe bam.

_ Proparo yourtest spray by 

### mixing one teaspoons of PREpf>o! in 

### 1qUM 

### of

### w~tor. Spray each tost plant with about 1

### oz. of this mixlure, covering aU loaves with a line mist. PREPtl<! brand Ethephon will notcolorimmature sprayed laaves. WHEN 

### TO HARVEST All 

### maturo, sprayed loaves wUl 

### beg!n to color within 2410 72 

### hours aftor PREpTloI brand Ethep/lon application. The yollowing procoss 

### is weathordependent; cool weatherwiU delay, while hot. 

### sunny woather can spGed up the process. Harvesttreatod lobacco whenleavos have reached the dO$lroo color Inlensity. Do not allow tobacco 

### to b&oome over ripe before starting harvost. loafdrop can occur when tobacco is ovor

### ripe and left on the stalk.. M

a numberof tho bottom loaves have yellowed at tho timo ot treatment, 1hoy should bo 

### harvested prior 

### to spraying with PREpTW brand Elhephon. • • 

## •••••

## • With 

### an ovor·the-top application, harvesting 

### can commence 

### 24 hours after PREpm brand Ethephon application depending on weathor condilions or

### to avoid 

### ovor ripe tobaa:o. Tobacco 

### harvosted 24 hours 

### aftertrea1mentwill roquire moro time in tho nloJirlg

### phase 01 tho

. 

# . . curltlg procoss. •••••• • ••• 

### • 

## •• CURING PREp1\I TREATED TOBACCO : .: • Curing ptoooduros are as much an art as ascience and oach cure must 

### bejudgod on tho basis of**~** 

### condJltvl,"q,terval betwGen Ireatment and harvest, we.thor and typo 

### of ctJring facility boforo proscription tomporature 

### an; VGf.Itlfati<fn adtodulos can be estabUshod. To obtain maximum quality, care must 

### betaken to obselVo and contmltho curing proceoooCJoSOlytfleefa/1y during tho late -coloring- and aarly -drying- stages of

### the 

### loaf. ••••• .: 

# • • PREpn. brand Elhephon treated tobacco 

### wiU have startoo tho coloring processwhon harvestad, reduckJ.the time rtK(Ulrod In 1ho coloring phase of 

### curing. Trealed tobacco

### should be dried faster. 

### IftoblKXX) leaves are green oroontain same grtoQWflon harvoslod, it may be necossary10 colorthem for 

### a few hours. Ifthe leaves are completely yellow, temperature 

### and**ventHation~a8t** 

### be adjusled 

### in a 

### mannorto dry tho

### tobacco as 

### fast as possiblo without 

### scalding. 

### Onoatho loaf Is dried (314 dry), 

### you should followonormal procedures 

### forcoring. SitlCG PREpnI brand Ethaphon treated leaves cure lastor, treated and unlreated Ioavos should not**bo~~"**

### regather in the S!l:t10 

### barn. 

# 168

# LIMITED WARRANTY AND DISCLAIMER :;... manufacturerwarrants fa>**th~t** this 

### product cooforms to tho chomal d&&cription on the 

### 1aI»I; (b) thallhis product 1$ reasonably fit 

### for tho purposes sot forth In tho dfr8CIions for 

### usa when it 

### Is used In accordance with such directions; and (e) thai tho directions, warning and other slatements on fhls label ate based upon reoponsiblo oxperts' evaluation of 

### roasonable fosls of 

### ettectiV8noss. of toxicity fa laboratory animals and to plants. and of

### rosidua. on 

### food crops and 

### upon reports 

### offield experience. Teals have 

### not boon mado on all variatio;or In aU 

### statesorunderaU conditions. THE MANUFACTURER NErrnER MAKES NOR INTENDS. NOR DOES IT 

### AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES. EXPRESS OR IMPLIED, ANO IT EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPUED WARRANTIES OF MERCHANT·ABILITYOR FITNESS FORAPART1CULAR PURPOSE. 

### nilSWARRANTY DOES NOT EXTEND TO. AND lHE BUYER SHAU BE SOLelY RESPONSIBLE FOR, ANYAND ALl

### lOSS OR DAMAGE WHICH RESULTS FROM THE USE OF THIS PRCOUCT IN ANY MANNERWHICH IS INCONSISTENTWITH THE LABEL 

### DIRECTIONS, WARNINGS 

### OR CAUTIONS. BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY ANO ALL CLAIMS, LOSSES, DAMAGES, OR INJURIES RESULTING FROMTHE USE OR HANOUNGOFTHIS PROOUCT, WHETHEROR NOTBASED IN CONTRACT, NEGLIGENCE. STRICT LIABILITY INTORTOROTHERWISE SHALL BE LIMITED. ATTHE MANUFACTURER'S OPTION, m REPLACEMENTOF, OR THE REPAYMENTOFTHE PURCHASE PRICE FOR, THE QUANTlTYOF PROOUCTWITH RESPECTm WHICH DAMAGES ARE ClAIMED. IN NO EVENT SHAllMANUFACTURER OR SEllER BE LIABLE FOR SPECIAL. INDIRECTOR 

### CONSEOUENTlAlDAMAGES RESUlTlNGFROM 1HEUSEORHANDlINGOFnilSPRODUCT. NOTICE TO BUYER Purchase 

### ofthis product does not confer any rights undor pationts governing this productor tho use Ihereol in countries oUlsido oftho United Stat8S•



### • IDEF and 

### Gulhion are registored tradomarks of 

### BayorAG, Germany. 20ropp is a registered Irad.marie:: 

### of NOR-AM ChomK:al 

### Company. 3Harvado is a registered trademark of UniroyaJ Company.



# • 4MaJathion is a trademark 

### ofAmorican Cyanamid Company

.



### Rh6no-Poulonc

### Ag Company P.O. 

### Box 12014,2T.W•

### .Nexander Drive 

### RosNl'Ch Triangle Park, North Carolina 

### 2n09 

### PREP is tho trademark

### 01 Rh6ne·PoulenciorElhophon Cotton Boll CponOf' FOlEX is 

### aregislorad trademarkof 

### RMno-PoulGnc. PREpn! brand Ethophon for Cotton and Tol::lacco (PENDING) Submitted 10123192. 

## •••••• 

## • 

# •• • •• 

# • • •••••• 

## • • • •



# ••

• t •••



## • • • • 

## ••••• 

## • • 

## •••••• ••••• • •

••t • 

# • •• 

## • 

# •• • • 

## •• 

## ••• 

## • • 

# •

•• • 

# • •• 

## " 

# .

•••• •• • •• • 

## • ••



# 169

# •

• DATE: / /- 

# k

- 2).

TO: FILE ROOM 

### DOCUM.ENT CENTER 

## PRODUCT MANAGER PAM (ROOM 263)

TXfE Qf 

## REG!STRATION PAST

- TRACK ACTION This action has been determined to be a fast-tracK action 

## by FEPS and**~** 

## be entered in the 

## PRATS using one of the following codes: 160

- Application for 

## "me-toll registration 170

- Application for registration

- old chemical

- "Metoo lf 

## with 

## additional use. 

## 300

- Amendment

- label revision

- administrative (no data required). 

## 305

- Amendment

- label reVlSlon

- 

## data required does not 

## need HED/EFED review.
J 10

- 

### Amendment

- added "me-too" Use

- no HED/EFEO review needed• 

## 345

- Formula change

- no HED/EYED review required. REGULAR REGISTRATION (with data/without data)
24C NEW



## R%8UDHIBSION Cr••pan•• to Aqancy ltr) PlHAL'PRINTED LABBLS
OTlDlR 

## KESBAOI'

__________________________________________________ __



# 170

# •

• UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON,O.C. 20460

MARGARET CHERNY 

### RHQNE-POULENC AG-COMPANY 

## P.O. BOX 12014 10/30/92



## RESEARCH TRIANGLE PARK NC 27709



## Product Name: PREP BRAND ETHEPHON FOR COTTON Company Name: RHQNE-POULENC AG COMPANY 

## Application No.: 153345 EPA Reg. No.! 264-418 EPA Receipt Date: 10/28/92
Subject: Front End Screen for an Amendment



### Dear Sir or Madam: OFFtCEOf PESTICIDESANOTOXIC 

### sUasTANCCS



### Your application for registration has been received by 

### the 

## Office of Pesticide Programs and has passed a preliminary screen for completeness. It will be placed in line for review to 

## determine its acceptability. The- application will be processed in chronological order of receipt. Although the 1988 FIFRA amendments mandate EPA to review applications for expedited registration or amendments within 90 days I 

### this turnaround time will not be met immediately due to the backlog of applications received before December 24, 1988. However, EPA is increasing human and automated resources and making necessary procedural changes in order to eliminate the backlog and to meet the 90-day response time as**s~on** 

### as 

### possible. If 

### you have 

### any questions, you may contact C. 

### Giles-parker, Product Manager 22, 

### at (703)-305-5540.

Sincerely,

# ~.uJ~ Team Leader Front End Processing staff Registration Support Branch Registration Division (H7504C)



# @ Printed

### onRecycledPhper 

# 171

# r !



# •



# • Mr. Warren A. Davis Rhone-Poulenc Ag company P.O. Box 12014, 2 T.W. Alexander Drive Research Triangle park, He 27709 Dear Mr. Davis: Subject: Revised Labeling 

## PREP Ethephon cotton Boll Opener EPA Registration No. 264-418 

## Your Submission Dated June 30, 1992 The amendment referred to above, submitted in connection with 

## registration under the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA), as amended is acceptable provided that 

## you: 1. Make the labeling changes listed below before you release the product for shipment bearing the amended labeling:

you 

## Modify the Environmental Hazards Statement to include the 

## following statement: Do not apply directly to water, to areas where surface water is present or to intertidal areas below the mean high water mark. 2. Submit one (1) copy of your final printed labeling before release the product for shipment.

A stamped copy of the labeling is enclosed for your records. Sincerely yours,

# ~/**/~**

### / 

## Cynthia Giles-Parker Product Manger (22) Fungicide Herbicide Branch Registration Division (H7505C) Enclosure



# 172

# •

• • 

# PRE

# PTMBRAND ETHEPHON COTTON BOLL OPENER

INE:RT INGREDIENTS:

............................................................................................................................44.6% 

# KEEP OUT OF REACH OF CHILDREN 

# DANGER PELIGRO
PRECAuctoN At

### USUlJUO: SI ustod no 100 ingles, no use osto producto hUlaquo Ia informacion on 1& e1ique1a. Ie haya sido oxplicado

Th. usa of this 

### product for a variety 01 plant 

### growth regulation U50. is covorod by Unitod Statas and foreign patents including U.S. Patents3.879,188 and 4,240,819. No Ilconse is grantad 10 use this product 

### in counlrios olhor than tho United States or lor any us. 

### not conlomplateci by 

### this label. Liability for patont infringement may r85uh from use or sal. of this product outside tho United

- S1ales

. 

# STATEMENT OF PRACTICAL TREATMENT

IF IN EYES: Hold oyelkls open and flush with a genlla stream 01 wafer lor at loast 15 minutes. G01 medical attention, prelorahly an ophthalmologist. 

### IF ON SKIN: Immediately wash skin with plenty of soap and waler. Romovo contaminated clothing and shoes. Wash clothing separately bolore rouse

. • IF SWALLOWED: Do not 

### induce vomijing. Prompdy drink a large quantity 01 milk. 

### tI99 whiles, gelatin sotution or**~** 

### those aro not



### lfIalJablo, drink large quantijies 01 water. Avoid alcohol. Call a physician immediately. IF INHALED: Remove victim to Iresh air. "not breathing. give artificial respiration. Administer o:tygen il necessary. Get medical attention. 

# PRECAUTIONARY STATEMENTS DANGER HAZARDS TO HUMANS AND DOMESTIC ANIMALS CORROSIVE. Causes eye and skin damago. May bo latal**~** 

### absortxtd through skin. Harmful 

### if swallowed or inhaled. Avoid breathing spray mist. 00 not got in eyes. on skin oron clothing. Woar luilleogth trousers, long slooved shirt, prOtectivo 91ovO$, and goggles orfaca shield whon handUng. Chango 

### to clGan wOlkclothes daily. Wash thoroughly with soap and water aftor handling and before oating, orsmoking. Romovo and wash rontaminatoo clothing bolore reuso. Koep away Irom domestic animals. 

### NOTE TO PHYSICIAN Thoro is no spocific 

### antidote. Alltr.atmont should bo 

### based on observed signs and symptoms 01 distroS$ inthe patient. Overexposure to 

### materials othor than thll. product may have occurred. Victims 01 saveret overexposure, by 

### inhalation, should bo kept undor medical oil&olVation lor up to 72 hours lor dolayod onset 01 pulmonary edema. In a victim 01 ovorexposuro by ingostion, careful gastric 18'\1age is lequired due to th. possibility 01 stomach or esophagoal porteration. This mat.rial is an acid. but use 01 alkalino substances to neutralize 

### it is ronlraindicated. 

## ENVIRONMENTAL HAZARDS ••• 

## • Do not apply 

### directly to water or wetlands (swamps, bogs, marshes, and potholos). equipment wsshwa1ers. Do not c:w;r;runato wate'Allen disposing 01 00 not contaminate wator usod lor irrigalion or damoslic purposes. 

## USE PRECAUTIONS • 

## • • • 

## • 

## • • 

## • •

## ••••• • 

## • 

# • •

•• •



## ••• • 

## •• Do not 

### apply PRE?n' brand Ethephon Cotton Boll Openerthrough any 

### typo of Irrlgalion systam. ..:... •• • Avoid spray drift 10 n04lby crops asthis productwill causa modifICations in plant growth. Plant infuf1e,;oducod yiOlds wiU result. 

### • •• Do not pfant anothercrop within 30 days aftartreatment. ••: ••• Mix only the amount ofspray

### you 8Xpoc1tO uso oach day. 

### Do not allow mixed solution 10 stand overnight. 

## •• • 

## •• • • 

## ••


# 173

# DIRECTIONS FOR USE It Is a violation of Fodoral Law to use this product In a mannor Inconsistent with Its labollng. Road entlro fabel boloro using this product. 

## REENTRY STATEMENT Mixors, loadors and appficators must wear a full faco shiok:!, long trousors, long SIQ9v(Ki shirt, glov9s and boots 10 avoid as much skin and eyo contact as possiblo. Do not onlortroated fiolds within 24 hours after appli<:alion unloss proloctivo clothing is worn. 

## ::;luRAGE STORAGE 00 

### not conlaminalo water, food, ortoad by storago ordisposaL II containor is broken or contents have spilled, follow all precautions indicated above and clean up immodiately. 6010ro cloaning up, 

### put 

### on fun 

### length trousers, long sleeved shirt, protective gloves, and gogglos or face shield. Soak up spill with absorbent media such as sand, earth orother suitable material and dispose 01 waste at an approved waste disposal lacility. PESTICIDE DISPOSAL Pesticide wastes are acutely hazatdous. Impropor disposal 01 excess pes1idde, sptay mixture, or rinsate is a violation of Federal law. 

### I! these wastas cannot be disposed 01 by use according to label Instructions. contact your State Pesticide or Environmenlal Control Agoncy orthe HazardousWaste representative at Ihe nearest EPA Regional Office lorguidance. CONTAfNER DISPOSAL

• Triple rinse (or equivalent) the empty containers. Then offer lor**re~ycling** or reconditioning, or puncture and dispose 01 in a sanitary landlltl. or by' incineration or if altowGd by stato and local aUlhorities, ov bUrnina. If container is burnod. stayout 01 smoke.



# • GENERAL INFORMATION A follar spray of PREpN brand Ethophon Collon Bolt Opener win accelorate opening 01 malUro unopened cotton bolls and anhance defoliation which can rosult in oarlier harvost with an incre8s;ed recoverable yield. PREpn.! brand Ethephon Cotton Bolf Opener • treatment allows increased efficiency from a onCG-ovor harvest. Some premalure drop ot small, immaturo bolls may be associated wllh

t!eatme-nt. Do not apply before sufficient, maturo, unopened bolls havedevalopad to producethe desired yield ofcotton. 

# A

bon is malUtO when it is too hard to be dented when SQueezed betweon thumb and fingers. too hard to besliced with a sharp knifo. and

# t! when tho saod coat bocomes light brown in color. For bast**nisu~s.** thorough and unitorm spray covorage is required. It is essential that tho bons are contacted by tho spray to obtain optImum boll opening. Obsorvo treated fields closely. Harvest at optimum boll openIng and defOliation. genorally 14 to 21 days atter treatment. Sustained cool watlther with average day and night temparatures of 

### SS'F or lower after treatment with PREprn brand Elhephon Colton Boll Openorwill delay tho bolt opening rOllponse. 

### Do not apply PREpnI brand Ethophon Cotton Boll Opener if rain is oxpocted within 6 10 

### 8 hours. Rainlalt within 6 to a hOUrs of application may reduce product poriormance. Cortifiod cotton seed growers should observo boll and sood maturity belore Ireatmentwith PREpllol brand Ethophon Conon Boll Opener. Bons not completoly mature might open with treatment 01 PREpn.t brand Ethephon Cotlon Boll Opener giving lowerquamy seed

. Spray deposits of PREpTM brand Ethephon Col1on Bolt Openor, when loft on aIrcraft acrylic plastic type windshields for longer than t hour, may react with this material. forming an opaqw\I film or spots onthe surface which cannot be removed by washing wilh water or any other cteaML Rinse windshields with water immediately after each lankload of PREp":'!>!. brand Ethephon Colton Boll Opener has boon 

### applied. Thoroughly rinso tho aircralt with cloan water alteroach day PREPrn brand Ethophon Cotton Boll Opener is applied. PREprn brand Ethophon Cotton Bot! Opener may also allect**co~ain** paints, and if accidenlal depositson paintod obiects such as cars. trucks, agricultural equipment. etc. occurs, those objects should be rinsed with water as soon as possible (within 1 hOUr) to prevent permanent staining of the painted surface. SPRAY PREPARATION Add 1/2to 3/4 01 the required amount 01 water to Ihe spray tank. Start agitation. Add tho roquired amount 01 pREprn brand Ethephon Colton Boll Opener, and the remaining amount 01 water. Proparo only as much spray solution as can be used onot+lo day of mixing. 00 not aUow spray solution to stand overnight. Do not spilt tho concontrated product on spray equipl'Tl()(\f.*Gl'.any airplah.**~arts.** 

# • •• ANY SPILLS SHOULD BE RINSED IMMEDIATELYWITH PLENTY OFWATER. : .: • Use of a nurse tank is highly recommended lor aVOiding possible spills ofconcentrated**lormulatic"~~ay** equipmant or any 8irp!ana 

## • •**"~** 

# . .



# .. .. 

# . • •• EQUIPMENT CLEANING 

## ••••• ••• 

## • • Because of Iho acidic nature of this product, prolongnd exposure to spray deposit will**damag~nD'Jic** plastics.acertain paints, and metals. • •• 

# ., 

# . Rinso thoroughly with a detergent and water alt oxposed acrylic plastic·type materials (e.g

.. aircralt**windshioldsj,~M** paintQd $uriacos within an hour alter exposure to spray deposits. : •••• At the end of each day. rinse thoroughly with a detergQnt and water all the metat pariS of tho <lircratt and thctassociatod spray equipment oxposed to the spray deposits. 

# 174

# •

•

j

# l .-

.._. 

## -----------------
PRETREATMENT WITH DEFOLIANTS PRIOR TO**PREP~** 

## PLANT REGULATOR Ifthe cotton is ovorly rankor laying down in tho middlos and good spray covorago oftho bolls with PREpno is difficuk, a pretraalmont with dofoliantswill be usofurto improve boll covorage with PREPJ'I.I. Usc dosage ratas of PREPn; Plant Regulator rocommondod for beR opening. Road and observe al! appropriate labor use directions and precautions for tho defoliant used. Do not oxcGGd a maximum of 2.0 !b aVA for tho combinG<.! use as a proconditioning treatment for dofoliation and cotton boll opening, 00 

### not use a dofoliant boforo**ther~** are sufficient mature unoponod balfs 10 produCG tho desirodyio!d {SOQ Genoral Information sQction on How to Tost for Boll Maturily}. 

## BOLL OPENING Spray Volume Rato 

### rGarslA! Condltfons expectod t 

### Gallon Application 5-7 days aftar tr.atment prnts/A LBS A.r. Treats Ground 

### Ar, Timing Hot and dry 80" For higher t-113 

### 1.0 6 Acres t5-50 2-5**~** Apply when the number Dry and 75 to 800 F 

### 2 1.5 4 Acres 

### or mature unopened bolls is sufficient to Cool bul higherIhan 65" F 

### 2·213 2.0 3 Acres produce tho desired Rank cotton 2-2/3 

### 2.0 3 Acres 25-50 

# .... yield.
RESTRICTIONS: Boll Opening
• In California and Arizona use a volume ot no less than 5gallons por acre for aerial applicalions

. 

## PRECONDITIONING FOR DEFOLIATION Spray Volume Rato 

### (GaISIA) Conditions expeclod 

# , Gallon Applfcatlon 5·7 days aftor troatmant PlntslA LBS A.!. Traats Ground 

### Ar, Timing Act and dry 80· For hlgher 

### 213 0.5 12 Acres 15-50 2_5

### d" Apply 4 to 7 days prior Cool but higherthan 65° F 1-tl3 

### 1.0 6 Acras deloliant application or tank mix with the Rank col\on t-tl3 

### 1.0 6 Acres defoliant application (soe Compatibility soction). Do not lank mix with dosiccanls unloss desiccation 

### I, reQuired

.



## . :tESTRICTlON5: Pracondltlonlng for Defoliation
• In Calilornia and Arizona use avolume 01 no less than 5gallons par acre lor aerial applications.
• Do nOI exceed a maXI-mum ot21bai/A lor lhe combined use as a preconditioning treatment lor dafolialion and colton boll opening,
• Do not use a defolianl before there arG sufficiant maluro unopenod bolls to produco Iho dosired yfold (sso GGnoral Inlormallon). COMPATIBILITY PREpm brand Ethephon Colton Boll Openor is compatible**w~h** DEF'.**FOLEX~,** DROPp2, HARVADE3. METHYL PARATHION. GUTHIONT AND MALATHION'1, and may be applied in sequence or as a tank mixture (00 NOT TANK MIX WITH DESICCANTS IF cOnON IS TO BE SPINDLE HARVESTED). In some cases slight reduction in boU opening rosponsa has baan observed when lank mixes with defoliants were used. Good agitation in the spray tank is Gssential and a tank mi:dure should not be: aHowed to stand withoul agitation for mora than 5 to to minules. Read and obsGlVe all appropriate label use directions and precautions for the deloliants and**Insecticldvl1~s~.** PRECAUTION : ••:-: _. 

# . 

# .. - Do not tank mix PREPTM brand Ethophon Cotton Boll Opener with**defollan~** co"talnlng sodium chlorate because this relulls In Ihe formation of hypochlorous acids which upon heatlng·.mit toxic chlorine fUmes. WHEN TO HARVEST • ••• ••• Do not harvest cotton sooner Ihan 7 days alter a troatment Wilh PREPw brand Ethephon Cotton**B'il1,l~nor.** •
..... Observe tho trealed crop and harvest when optimum boll opening has been reached. Too early h'1l¥ht might reduce the full advanlage 01 tho troatmont and too lata n harvesl may result in roducod quality and loss 01 lint which 

### will dropfrom ihe plant

. •••• 

### ••••



# ., 

## • 

# • 

# . • ••


# 175

# •

• • 

# LIMITED WARRANTY AND DISCLAIMER Tho manuillclurorwarrants 

### (althal this product conforms to tho chemical description on tho label; (b)lhat 1his product is reasonably 

### iii lor tho purposes set forth in tho dilOCllons for use whon it is used in accordance with such directions; and ee) thai the directions, waming and other statements on thlslabol aro based upon responsiblo exports' evaluation 01 reasonable les1s of onl)(:tivoness, of**toxic~y** to laboratory animals llnd to plants, and of residues on 

### food crops and upon reports 01 field experienco. Tosts have not boon made on aD varieties or in all states or undor all conditions. THE MANUFACTURER NEITHER MAKES NOR INTENDS. NOR DOES IT AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES. EXPRESS OR IMPLIED, AND IT EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANTIES OF MERCHANT-ABILITY OR FITNESS FOR A PARTICULAA PURPOSE. THIS WARRANTY DOES NOT EXTEND TO, AND THE BuYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND ALL LOSS OR DAMAGE WHfCH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENTWITH THE LABEL DIRECTIONS, WARNINGS OR CAUTIONS. BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, LOSSES, DAMAGES. OR INJURIES RESULTING FROM THE USE

### OR HANDLING OFTHIS PRODUCT, WHETHER OR NOT BASED IN CONTRACT, NEGLIGENCE, STRICT LIABILITY IN TORTOR OTHERWISE SHALL BE LIMITED, AT THE MANUFACTURER'S OPTION, TO REPLACEMENTOF. ORTHE REPAYMENT OFTHE PURCHASE PRICE FOR, THE QUANTlTY OF PRODUCTWITH RESPECT TO WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, INDIRECTOR CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OF 

### THIS PRODUCT. NOTICE TO BUYER Purchaso 01 this product does not conlcr any rights undor patients governing this product or the use therenl in countries outsido 01 the Unllod States.

The use of this produCllor 

### a varioty 01 plant growth regulation uses is protected byvarious United States and loroign patents including U.S. Palents 3,879,188 and 4,240,819, No license 

### is granted to usa this product in countries other than tho Unilad Slates or for any usa nol contemplated by this labal. liabilityfor patent intringament may result from usa or sale 01 this product outside the United States.

t DEF and Guthian ore registered trademarks ot 8ayor AG, Germany

. •::Dropp is a registered tradamark 01 NOR-AM Chamical Company.



### 3 Harvade is 

### a ragistered trademark01 Uniroyal Company. 4 Malathion 

### is atradGmark 01 American Cyanamid Company.

)

\ 

## \

RhOno·Povlol'lC Ag Company P.O. Box 12014, 2T.W. Aloxander Drive Resoarch Triang!9 Park, North Carolina 27709 PREPlu is atrademark 01 RhOna·Poulonc, Folext is a registored trademark 01 Rh6ne-Povlenc

. 

## ACCEPIED _COMMENTS 

## In 

## EPA Lett" Dat«l,**rJ:'d~,,-** 

### lhe )'i·Jcml In:-,ectiode**:·'.".l~'** 

### ;:{ooenti.cide Au**"~".** 

### ",,'''''1 I', .k.•**~-~;....<,~'" '".~_"."c~,**  '.1 Uf<;:**J~""'-** 

### ",,>d Ilnilfr 

### EPA

## Reg.m 

# ,;/4' '/- If

## II? ']

PREPTI-! brand Ethophon Collon Boll Opaner (Pending) Submitted -,_191. 

## •••••• 

## • •• 

## • •• • 

# • •••••• • 

# • • •



# •• ••••• 

## • 

# • • • ••••• ••• 

## • • 

## •

•• •

••• 

## • ••

•••



# • • •• 

# •• 

# •

•••• 

# •• • •• 

## • • ••


# 176**r-----~'---** 

# •

'" '''-**RH6NE~POULENC** 

### AG COMPANY



### ETH·92·11 June 30. 1992 U. S. Environmental Protection Agency Office of Pes!icide ProgramsJDocument Processing Desk Room 266 A. Crystal Mall No.2 1921 

### Jelferson Davis Highway Arlington, Virginia 

### 22202 Attention: Cyn1h!a**G!!es~Parker** 

### Product Manager (22) Fungicide Herbicide Branch Registration Division (H7505C) "-'-'" 

## -



# e Dear Mrs. Parker:



# • E!hrel® brand Plant Regulalor for Pineapples and Sugarcane EPA Reg No 264·257 Ethrel® brand Plant Regula!or EPA Reg. No. 264·267 Cerone® brand Plant Regu!alor EPA Reg. No 264·377 Prep® for Cotton brand Plant Regulator EPA Reg•. No 264·418 The appended label amendments lor ethephon containing products include a general format change with use directions now presented in tabular form. The amendmenls are intended 10 simplify proper use directions and consolidate information in one section 01 the label. In addition a patent stalement has been added 10 the front panel of each label. This statemenl is now unilormly included on all ethephon produc!s. Cer1ain other editorial changes have been made thai are consislent wilh the last EPA approved label. For instance certain volume,rate and !realment liming ranges have been modilied !o recommend only one value ins!ead of a range. To complete our submission we are including an application for amended registration and 5 copies of each label. We would appreciate one stamped approved label relurned for our tiles to facilitate state registrations and avoid any enforcement queslions. Thank you for your assistance in this registralion acllon. If you have any queslions please fee! tree to contact me promplly. (919-549-2379) 

### Sincerely.
_

# -a/r2~/4:'l\<

# }\ Warren A. Davis Senior Registration Manager •••••• 

### • 

### •• • 

### •• • • •••••• 

### • • • •



### •• 

## ••••• • 

### • • • ••••• ••• • 

### ••



## •• •

•

### •• • 

### ••

•• •

• 

### •• •• •

•••• PCi30,_';(iH 2'NALE.I::',LL'£" :"«'C nGEfopC'lTnYI<';v:roMW**'~,:** :';:i" '9'91**~,,19** ;,)JC 

# .. 

# . •• • • 

## •• ,qT[ANA1.(,hAllilIJhU/';"! _,\'!.,i,c;'i--'J.,,-' 'Ill' I'"**~I;Wt!·11("4i'\L** t:i'7"<!;,C," c; ",**~, ~i**  i '. , '",'.'''''-" ",<,in: ?i' ',\, .y-**"~'** " 

# 177

# ,



# . on MIfMllfI


# .nv." (A)

# &EPA UniWd Status Environmental PrOlOCtionAgoncy 

## Registration 

## loPP loonllilcr NlImbm OffiooofPesticide Programs (H7505C)

# ~ Washinglon, DC 20400 

## Amendment Applicationfor Pesticide: Other 

# 156138

" I 

## I" " N"",b." 

# 1',_EPAP,,,,,",, 

### I' 

## C. "', 

# W Nona 

# D Relllr'.tt&d 

# 14. CcmpanylProduct(Namc) 

### IPM. 22



## PREpe brand r I 

## Boll Is 

# """') Is. Expedlled Rovlew. In 3(c}{3j 

## Rhone-Poulenc Ag Company (b)(i), 

### my product is similar or idenlicalin composition and labeling 

## P. O. Box 12014, 2 

## T. W. Alexander Drive 10: 

## Research Triangle Park, NC 27709 EPA Reg. No.



### - 

# o ChfJGkifthis is aJ'Wwsd:kf}$S " N. 

### 01 [" Amondmenl·E>:piain bo1ow Rnalpilotedlabels in mtpOnSQ to

# ~ Rewbmfukm in rosPOO${) to Agency wlUIrdatIKI 

## I- Agency kltterdated**.~""~-** 

### ---,-----, 

# != NotifICation· Explain below. 

## I- °Me Too'**AppllCa~O(L** Othor· oxpkiln below,

: Uro additional page{s) if necessary. (For ,cc\lool and 

### &1e1km II) 

## Reformat of labels to include easYcto-read tables for use directions and update of patent statement on front panel of .label.

1111 " 

# ". II

.. d ,,, 

### IUo" I Yes 

# 12

# ~h. .,,,, 

# BYOS.

# ~" f-- 

## I--

# j~~~~ No No 

### No 

## I--

# I**~;;;;;,** No po< I

### 'Y"~:~ No. P'" 

### • c.rtiflcatlon

### mustb. wgl. container Polckago wgl. 

# r.- I 

### I"**Si'~'1** 

### '""',

..Coo"'m", 

## I 5, Loe>':,"

### ~"'" I 

# Ou.oot n 1 6 

# , ITo**P","'~** 

# 1= DOlhCr( 

### 1

# ~ ;to 

# rr; I""""

" 

# :.,' ' •Cod'J 

## Warren A. Davis _co"v. 

## Registration Manager 

# T: • •••••• 

# 15. Dat, Icertifythatthl! statemcnts Ihave made on this form and:aU al!ru:hmoots themto arc

## ~ncaJrnre Mdccmp{el( : IlICkoowfOOgo lhatany knowingly taloo ormisk:tuding slatemoolmay be punishableby line Of imprisol'UTlMlIor •• 

# .._....

# , both underapplicabto law, 

## ••••• 

## ••• • •

# 12~ 

# II), I' Ti"" •• i •• 

## • 

## • •• 

## Senior Registration Manager • • • •••• 

# . , • • 

## • • 

# D,,. • 

## •• l'tT: Warren A. Davis 

## June 30, 1992 

# 178

t'A ronn ti3ttl-l II1vv.12-80} \Vhf",· EPA 

# y".w ,'oopy

### <,


# •**'(j!tl~€;RWf~2H~~~r** P\Jh!ic J'tpbnlnu twd40 for thh coiU:ction of infcrmatiN\ 

## is Mtit>**(~/** 

### to «4Ti'!:00 D,t!5 hour f*t**r€*~e,** iR:lwdln;! nill¢' for reY!$¥{tiU Imtrw;:OOf;e, ::,urthiftiJ existlfl{) d"t1! SG.ifCCS" 9/Ilth;/ ¥4 AJ;infc ir,ing the**ciM~** ooe-OOd, nrrl**;::(~}t$t h"i@,~**  fWii,W'k,*, t?,? i'4t(ilferjv, of lnfbt;r&tlGf1.**~$id** (;oorr#iltg**c."d'j,i~-m0** :w/0t:h eBtiuat(' or &if( Gth>ef P1 thlii-t0ttect:1m ¢f lnf1HlMIt:l¢h", including tL'G(}ottim'd for**r~jr(J** thit> bt..rttRh, 10 Chid, rrd(),®4tf&1 Pulley 8rBf!!;l1, hAL Ehv!rGf'fflifflt2!t ¥ntccthm Allt:n.:y, 401 N**Strt~t, ~\l,**  IJtnhfngtoo, DC 2Q4(.,(;; ",4 Hi tiw Cif itt Qf In{w§"£tJon i'ird R0Sui¥i£ry 

### Aff

..)rs, jJffl©¢

## out l1.&"i!'>@!mlM''it ¥a flu6;wt,**tI~$h\ngt'A.** DC 20503.
lhh form is to be !J:$Nj tor sit**~tlclit!6?'m** for r1&W rq;i,gtfat!{)i1, end USl'? fHtgistrtitiOO, rmmrtiwmt, tetlJbqis$i&1,**t~ ~tjc~ti6n$**  fOf not1flc@tlcns. final pr1nted lWbttlhB.**r*regletr~tjcn.** ett. In**c(~r** to**proc~~g** wn**llflPH~du<** fer a mtI f%jisirMioo otl.lMlittcd on thit form, !tV! 

### +atlowing ltifitertlJl!1tl$t M;n:!ff{moy tim**~pptlc.,tlOl1:**

, tc/tiHc-&tlm "Hh**E~t** to ClUtier. of itlllt& (EPA form 8S7tl·tJi). Uf frot exwtptw by 40 

## en: 152,S1 (b) (4)); Cud**~«AtI{jt** Sfhtl'&Mlt ot fotmJta (EPA Fll:t'\l'I WrtH.); fMlNhHM'$ j>;jfi StbtdllUlt (EPA !©m**~rt.H;71;** c flve fT0iu 01 I;ili.eOngi ,>, ,,,"'_ d '*'ry' ihta**~ltted;** knlhl), tette!'" llhere apptie&b!e; L Nittlf@\(' ;Aery kiilite.**~h,;,h:n** ij**l~\lriJ·** L'4 $h«Jld first be**~fttcd** 

### in tht! form of draft tilbetl< with etl apptiCllt\.(i()G for flWI.< f'i!g<4,;4t\Oi;L S"u;h drwlt !li/OOf( my be In tile form of typod lllbct text on 6.5 K 11 inch JWfXtr or a /OOCkup of th¢ proposed t!'lb&L $ iii mv::hm, it l1-lwutd be con1J.trucred itl $O!:h i1 lOll)' n$ to fnc'ilitl!te storage in an ILS}( 11 inch file. _.k14) wigrMicynly W!l'A\!er thsn 8.5 x 11 indws shnUtd be**~ted** co 8.5 x 11 inch f)'lper for stkmiuion. Stbrdssim; d \tITlE

- Oat@ l;0tt!!iHel In**g~rt** of this UWtic3ti«l ml.ffit be sr..>lmiitttd in lKccrdMice with Pi!. lIoticc &-S. 

## SPf;S:31fl:£**:rm~AUCl'ION2!** Plt1{llW read the jnstn.ICtiOl'W nsted betow before- Cl':tl9tet1r;g this epptlcation. firM dttur0);n tM typt of tt1littr'ltj",..., ectioo, listed in Bto.::i; A, for which you llN sul::mitting this**~ticlltjon.** for appl.10f1il1<74 g;Jfmjtted in cy.o«tioo uith liew R&gigtfl'lthm ecti1O$, Sectloos I. lIl, and IV must Ire Cooptlft«i by**th~** appUU_DL hr Ilppticat!«w 5tJUaitt«i In**c~tioo** with I'!!MOded registratim Ktians, re:wt<l!issl(ltl$, rotiflcntlom, n,rfr<tr&-thx0, (\U:., S«;:tloos 1, H. and IV!WIit 

### Ire twpleted by the**upptlcMjt~** IItoc± li C1:--etk the appr-qufaie n<::tion for whieh you are**~ittfng-** thh fONfi.**~klJ:jlL.I ~**  

### !lih MiCtfeo oost be cOIfptet-OO. u 

### appHubte, for all registration "tlom. 1.**~¥lfJ~A£'t_** liul!lber

- lrw:rt y¢W'**c~ 1tI.JiIbw~**  If t.WWt hos ooen 

### ;1I;uillMd by EPA. Thill! li\mber**~y** have 00en &!lsigned to 0/00 M g b$!$1e resistrMlt, a di;;trlootor. or 1'1$ 1m ¢stabtii:h!r.ent. tf 'IOOr produet i$ t'egistsred. imert the- i'r«b:t**~,** 1:. 8'k i'ndxt**~ ~**  If**k~,** Htt In the I'!llffIe and PM nu'!ber of the £PA Product MM'IIX/!!r. 3. C-tM,.HipiUw.·' 5f*Cify the fU'OflOS;,ed clm:slflcatlon of thls pr-.xJtiet. 4. Prvnt IUiffiP ' t"lter Um Gooptete product name C!f thlil $xwtlcide IJS it 

### witt appear co the ttk.et. The nbIOO m.mt befff*.f-ifi-( t& this**pr~t** onty. OupticatiOfl of NIMW is Mt pcn§ltted among products of the SMe**c~.** 00 Nt inett.>dr! £!ftj tn;-v) h4if;0 tff**e~** lioe ilimignaticns. 

# •

';I.**~** AU Nfu_ -of AppUC4llt • The 00fIl¢' of the firm ¢ot' pef'$on -erd eddre$5 nhown In your np-plicatfon is th0' person or tim to 0";",,, Uw <"1

__ i)ittrat!M witl be- iHved. tf roo arc ectill9 in b¢hatf of MOthsr perty, 'tOO _t sul;Qit oothorhat'jon ftw! tkH potty f{; o:,t for them in registrlltion matters. Ah appliclmt not rcsiding 1n the United States IWSt**h~** an U',;1r,d 1;01 iYjW'i! raiding in da United StutCi to act fO!' thrun in ult regit-trlltion matters, Tha- I1MIe lind cOilptete JlWn ir.; t;OO;-tM (;1 nuh til agent JWt.t**XC~** this i'lpptieaH!)fl. • 6, E:"p,dit01 l1wieu " fHRA $«tiro 3 (c) 3 (II) prQvidtti; for excpedfteci revlw Qf appticati«n for t'eg\str.atton, or**~t** h H_;,-tt1'S tt-¥!lttr<lticns. that Itte IIlmitar or identi.;:tli to other pesticfd¢ products that {Ire C:Uf'rmt[y ft!gJsured with ' th'ifA. ir, Nevr for 'f$IJf .epptic4tion to be elfglbte for expedited t'lr«lew, you Iftnt provide Uli- wIth the EPA ReghUl'Itibfl**fu~-H** ","0 VG4K-t N>!m" of lilt product '(I:lU**betle~** b ;;Imitl!lr H> or identfceL to)'tlUr product. lhe prodoct m.nt b& $iw,bx f'd' i,j,':ntj,:;n-t in W1th icrnooll'lt'ion &nd labeted tmlil'$.**~::-~1~_L9{L_Lt** Hoi&- ,«,ct),:;--n tu!'.t be cornptetti-d fer all IlppllCtltJorn; !iubmltted to _nd the r¢gistratiM \WIly of tJ Cl.IrH:1d1y H?si;lMH, F"vm_oc-t {fu"1&.ru:Im&'lt), for -& t!"rslbll!llIst{;(l In rll'$pOfI$C to -fit!**A~y** tlltter. for Mtificati()f';$ to the Ageru:;y, N/ lLe ;;,d:wh$;Gfl d la'.nt printed taootlng, fer retftgi&tratlen and ior ally ether "ctiM that per(<liM to a IIp&dfi<: tea'!3:+l lhili- se;:;tlon is llil!. 

### Y1 

### 112 \Je.eU fur 3**~** 1!pPlketion fol" f09huatloo. 1. sli"-k,r

- C/;-ttd; Uw nppllctible block and provide the AlJC(!ty letter date if appr-oprbte-. Provide <I: brief eA[oL-;,{/Hk)t', ,1{ (fa P'ffpDte{1?1 for tho !to.A:missicn, juth M lithe ad:1iUoo of II tite, p;»t or crop (specify)";**"~f\rJ** the CtnrLhntk;( St;;;tww-ot of formuta by••••,; Olrercglstntioo stlb1liss!o-n"; geN-rnt t1l-tx!t nwlsion of We dirocti()fj$.

... Attach a Uf-4rM. t0i

... if tdjltiumt §pac¢ is needed, 

## •• •• •••••• 

## SEC'J.,.:tmLJ;,;UA (pco;taging and Gontainer Information)**~** This Section**~t** be coo;pteted for lilt IIppllu;nM$ M1:mhted 

### '11'**~tion** with new rc-gh:;tration or appilcllIbte IWrMdn!mts. 1. TYf:W of**p¥_~in@** ,**ClVl~** lIppf''Opf'iate btlW}: if yoor prG<duct witl 

### be pw:kaged in the indicat«-! packaging types. Jrrli(.(lbJ the fd;e of '«w indlviduat ptlCkeu 5'hd /"lI.tI'imr per retail container**~** 2. TYf:W 

### rA *"tJ"·1klhtain&·· tnd"lcllte t}'f» of (;MtatOCr in which prcQ:Jct 

### will be marketed. 3. lOCinloo -01**~t** 

### C«tteqt\-·;**~ify** the rna contents of all rtttsit cOfltl'llocrs fer your pr«.kJct. 4. Shms) ef it&t!}\!**C4nt'\t~.~** Specify the rw-t contents of :.U retail c«1toirw-t's for your product. 5. l«:0UM**~>f~:!}lnx:::ti_** - Indicate the location 

### ot tllf:! \JIl@ dlreetiooa for your Pfl:x:k;ct. 6. 1ItarK#:1' in Iti.io::-t. t;Wet hi tlffixcd 1;i) pnxir.::t**~** Indicate the method produ<':t**l~t** \5 QttllCh«l to. retail f!WltaiMr. 

## • ••**~IOO-,;,!!!** 

## :(Cgntstct POint)

. This Se<.:tloo _t be cOl'f9teted for ntt appticattOO$c for Regilltra,t"ioo actions, i.e., fN

..**pr~t!i** r«llstfatioo,**r~l£sIM, ~·tQO."**  reregillltrlltion, etc. 1-5.**S*tf~e)(p!MIDttlr-y,** 

# 1·79

6_ EPA Use 

### Cq!y_

# •

• :1:2: FILE ROOM 

## DOCUMENT CENTER



## lI!2lI' PRODUCT MANAGER
PAll (ROOM 263) 

## FRANCES WRICE
TXPE OF REGISTRATION**---~-~** 

## PAST

- TRACX ACTION (with

# d.t~:~out**d.ta~~~) '~**  This action has been determined to be a fast-track action by FEPS 

### and 

## m.w& be entered in the PRATS 

### using one of the following codes: 160
- 

## Application for "me-to" registration
170

- 

### Application for registration
- old chemical
- "Me

## too" 

## with additional use. 300
- 

## Amendment
- label revision
- administrative (no data required).
305
- 

## Amendment
- label revision
- data required does not need HED/EFEO review.
310
- 

### Amendment - added "me-too" Use - no HED/EFEO review needed• 

## 345
- Formula change
- no HED/EFED review required. REGULAR REGISTRATION (with data/without data) 24C NEW 

### HC AIO!HDHEHT 

## RB8UBKISSIOK (r•• 

## pon.8 to Agency ltr)**PlNAL~PRINTBD** 

## LABELS
OTRER 

### HB88AGB'

__________________________________________________ __



# 180**"---------------------'-.~----~---** .--'



### •



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# ,



# 181

# ,

• Mr. Warren A. Davis Rhone-Poulenc Ag Company P.O. Box 12014, 2 T.W. Alexander Drive Research Triangle Park, NC 27709 

## Dear Mr. Davis: Subject: Alternate Brand Name 

## PREP Plant Regulator for Cotton EPA Registration No. 264-418 Your Submission Dated April 23, 1992 

# -

The additional brand name llPREP brand Ethephon Cotton Boll 

## Openerll is acceptable and has been included 

## in the files 

## for this 

## product.

Enclosure 

## Sincerely yours,

Cynthia Giles-Parker Product Manger (22) Fungicide Herbicide Branch Registration Division (H7505C)



# 182**~------------~** ..**-~** .......**~**..**--~ ~~--.--**  ....

# ~ **RHONE-POULENC** 2'" , ,



# "

, RHONE-POULENC AG COMPANY**ETH~92-4** 

### April 23, 1992 U. S. Environmental Protection Agency Office of Pesticide Programs Document Processing Desk Room 266A, Crystal Mall No.2 1921 Jefferson Davis Highway Arlington, Virginia 22202 Attention: Cynthia Giles-Parker Product Manager (22) Fungicide Herbicide Branch Registration Division (H7505C) Dear Mrs. Parker: RE: Request for Alternate Brand Name PREP'" Plant Regulator For Cotton EPA Reg. No. 264-418 In reviewing the files for this product we noticed that there were several versions ofthe product name used by EPA and Rhone-Poulenc. For the record the product name originally registered is PREP'M Plant Regulator for Cotton. We now desire to register an alternate brand name for this product: "PREP brand Ethephon Cotton Boll Opener". 

## An application for amended registration accompanies this cover letter. We believe that a simple notification should be adequate to allow immediate use of this alternate brand name. II you have any questions please contact me promptly. Thank you for your attention to this registration request.



### Sincerely,



## Warren 

## A. Davis Senior Registration Manager • 

# .,

# .

• •••• 

### • •••• 

### • 

## •• • 

# . , 

# . • ••



# .

, 

# . · 

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# . ••••



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POBOX**12G'~?** ',) i,**~\g-Jr,FR!)H'-;:** '1ESI:IRCh**-"I"-",~i' ~'4J"{**  L:**'~~-:J** !gEJ! 5-19·2\)((1 j,'.'U1tJm-:if0lL**rne~** 'u'.U[n -i'I'i):

### "'J f.\-:-,';!.!'

### ,,< i' .'('1: "lj' N":::SNc'"y,I,L i11:;FHl'J[;{'!r,ah': U"',:>' j f**~",.J!;;~"** n'f'ji: ·\1 u,',U"'_'-c n', '-'._ 

# 183 •••••• 

# . ., • 

## • •••••• 

### • •



# ., ••••• 

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•••••• 

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# 1"

. 264-418 

# I" 

# I4

### Com~if"d",t(N""")

## ~, 

# 0 NOM 

# 0 RestrittOO 

### PREP Plant Regulator for Cotton 

# 15,**Na~nndAddr(tS$** . 

# Rhone-Poulenc Ag Company P. O. Box 12014, 2 T. W. Alexander Orive Research Triangle Park, NC 27709 EPA Reg, No",
_______________



# 1'. 

# o Check/Ifhi$is

### a Il&WsddtoS-$ 

### 11 Amendment·Explain below R&&Ubmiukm 

### in rfI'&por1lW toAgency JetterdatCdL

___ _**NOlmcarkm~** Explain below. Produc, Nam.

"Mo Too·App!ic3110ll OthGf' explain below, Usaaddilional page{$) II nocossary. (ForlIection tandSection 11.) 

# Request for alternate brand name: PREpTM brand Ethephon Cotton Boll Opener

Section III 

# 8:" p:'**~** 

# :'**hf~~'M~:---~** 

# NO-.,pN-.**~,,·~y.~,~:~--~N.-,pM--1** • CertlfIcBtJon

### mustIxI

# I container' PntkageWQL 

### I conlntnor

# I'~':of,""c;t;io' 

# I" S'''(:)0.1& bulk IS.

# ,'~'::"'"

.

# "~ ITi'" Warren Davis Registration Manager

IOOrtifythat the**$ta~mMlfg** I have mnde on this form 

### and a!l attGchrnents thentlo are [roo, 3<:Ctlrate andcomplete. Iacknowledge !halany knowingly false ormtslca:ding s!awmGnI may 00punishablehy lioo or tmprlsoortWrlt or bothIJtlderapplicable taw



### 1 

# 4'"'''''"_ Warren Davis

YA tRw.,.

... , 

# I' Titl, 

## Registration Manager

WhiI4· EPA 

## • •



# 184

# .. :

# .



# .....

•• 

# .:



# ....

# , PAPERWORK REDUCTION ACT NOTICE and 

## INSTRUCTIONS PAPEBNQRlS REDUCTION AC'll'fOlElb"E: Pubill:)**r~rt!ng** burden fcl' 

### this coll«tion 

### of infcnMticn is ontiwmted to**u\{"r~** {),as hoor per reSfxmu" Il'WtUtHog time fa/' rwtwfhG imtruetiOO§, searching eX\St1flii datil- scure:ci>, gatherlr',g and ff41ntulnfng the data**~,** 

### ;1!ncl**t~litf. M('LtM~j!%t·**  the eottw:tion of inflUl'llOtioo. Stnd ecmwffiU fegarXIing the burden estl!1Jil1te or any otliel'**d!~fif/m$** 

### IXIdifeHijif'ljef"'inf{;ffMtioo, Including iW9gostiem 

### for r«fuclflS this burdw, to CMot, fnformatioo Potky flrGt'idl, liFtCl, U.S.**Envlr~t-l1t** Protection A'J«\f:Y, 401 Mstreet, S'ri, UaShingtoo, DC l{)l.Ml; W1d to**th~** Office: ef lnforlOOficn &rid i/($jtatwy Mhlr'1t, OHlC{t {If**~t** &fId Budglit, \;'llsi1iogtcn, DC ZOS!);. 

### INSTRUCTIONS: ihl$ ferm is to Ix: wed for aU 

### aprl Itetiora for mw registratIon, Mid U$C reregistration,**~ndment,** r{l>"ul;mhltiOfl, to apptic<ltloos for notifiCl>tiOO$, 

### flrwt printed tMK!Ung,**rer¢Gf~ltrlition,** etc. lit order to ptot1?!;5 11ft**D~lir-ul1cm** fH $I r&l< regh.tratiOfl stbnittw (li"I thlu fl'ifill, 

## trw tQl!cwif\9 tMlte;lul _t**aee~** the apptltatien: 1. c&nlfkilltien with Relilp<!ct to Cit&tlm i;11 Oattl (EPA fen!! 001O·Z9}. [[1' rIDt t!.I<H'pt-ed by 40 CfR 152.81 (b) (4)J;**~.** Culfidootlal StntS!ll'!f1t of forl3JLs tU\l\ f'j':.rn 1i$7U·4); 3. f0rn11ator'lI Exll!!i'iptioo**$U:t~t** (!fPi. form**1W1O-~7);** 4. ftvt copies of draft [liNlin;l; S. Three copilu of 1M'!'{ oot6 stbflltted; 6, j\;Jlherlzntlon letter where**~llcabte;** 7. It4tdces Idlere awlieante. Stmbf-icro M l.abeling· Ll1belir.g §hoold fint bI: sl..f.Jmittoo In the f(ff1!! of draft iabels with all**~!ications** for nw l'egiStT0Hoo. toeh draft latwls may txl in the fOI"ffl of typed labet te];t" 00 a.s ;t" 

### 11 inch,paper 

### or a**~kl4>** uf' the ptop%ed 1.1. If pr;ipllrcd 00 a moek..", It shootd M conetfU!:t«l in Wdl a WIlly u t$ fMHit4M Jl:.tor9 in an tJ.5 X 11 Irn::h fHe. Moclop !clK!t2 signHicM'!tly _lier tl;lIft a,5 x 11 lnches 11;00ld 00 IMUlted on 8.5 x 11 incll p;!IpI!'r for uuhnia!!;ioo. S'l..tBiedoo of (lata**~** Data sul.nltted in**s~rt** of this swiicntlCfl nnt bI1 tWmltted in attordrocll" with PR notice 86·5. 

### SPECIFIC**INSTRUCTIONS~** Pl!'iil.t'J read the irwtructiOlW. Ililted 0010# be10N! cOOIpleting this appilcation. fif!>t tktcrminl'**th~** tyPe of ,cglstrllticn action, listed in Elt<xk A, for l4lici1 yw IIIre tut:r.ittina this applitat1«l. forapplicDtiOl"W $til;:tilitted In**c~tioo** lIlth New Rcglstntioo octltlf'lS, tecUCflS. I, lU, nod IV lIl'..&t be ccnpleted by the awlitM,t. for nppllcl'ltiorm. submitted 10 COl'¥'leCtion with**~** registration aetiornl, r;:J;obmissions, MtifiCQtlOfl'll,**reregi~fratjOO5,** etc., Sections I, !I, nnd IV**~t** be completed by the applicant. Bloci A

- Check the appropriate actIon for which**yc~** 

### are submitting this form.**~QLI** 

### - 1hl$ &ecticn II1mt be coopleted, iI-S rwllciibte, for nll reglstratlOfl m:tioru;. t.**~~t** JfIJIober

- Insert your**~ ~r,**  if**~** hn**~** owsisnod by EPA. lhb IlUII't»r may have bMm assigned to yV,J liS u basic registrMt, ij distributor, Of iI$ 1111 estnblishmoot. It your product fs regIstered, ilU.ert the PrOOuet" 

# -. 2. EM Product**~ ~**  If i;rnIol!l, fill In the I\i'lrnC MId f'H nud::rer of the EPA Pr«kIet**~r.** J.**Pr~Ad** Chmsificatioo**~** SpecifY the proposed tlMlification'of thh product. 4. Pnxhcr U-

- Enter the cOl!?tet<! product mma of this pettfdde os it \,Iill appear on the label. Tho M!OO'!lOSt be**~tdic** to this produ!;t ooty. lluplicatlotl of**~s** 1$ nGt pernitted amoog**pt~t$** of tll*,aIM**G~.** 00 not Include lillY btlWld**~** or**c~** line Oc$lgnatlon:s. 

# ,

5.

__ &'V,j At.kiress of Appiic:td'lt**~** The n!lI!IC of the firm or p!i:r!Kln ar.d adcirfl$$ 

### mMifl in your application h the persoo (lr firm to it?KlIiI too registratiOfl will be iutted. If you .ore aetil'l9 in behalf Qf utWthl:r p$rty, yW _t zt.bdt authorlZf.ltlon from tlwt jXlrty to act for them In registrlltiOfi matterti. An appfic:mt not rHfdII19' in the United St4tU must have an wth"rlzod $gmt residing in the Unitoo Stat"- to <lct far tnil«! in alt regiliitration motters. The rmme and coov:>lete maUl' addrti\s of !Ouch lin**~t** ra.nt .KGOI!pfmy this appLieatioo. 6. Expedited RWlew

- FlfRA sC'Ction 3 (c) 3 (S) prcwhk$ fer ('xpedh-ed review of 'appticat10M for registration, or**~** to cX\$ting reglstretiQn$, that**ar~** similar or Identical to other pesticide**~ta** thllt bre currontly registored with the 1;1'1.. i1) order fol' yoor apptlutioo to be eligible for expedited reviw. you IW§t provide us tiith' the EPA Regb'tratlon**N~r** nod product MIlle of tho product ymI bdiow III dmHtot to or i<knti"",t tQ )'<lOr pnxkx:t. Thll product !11U$t !a almHu M" iodentical in both fenmlatiM and laMtW U6'Nh 

## • !Jt.M**~~** - This soctien must txl cO!l'fIletw for all "PPI icatioro albilitted to**~** the r@Qlstratlon ooly of ($**JW1fr~tiy** reslst\rea product**(~t).** for l'I resubmissiQf1 In response to an**A~** letter, fQ4' notif\('fttiolls to the 

# .':i::-c;, for the 3ubBlsf;lOO of tim.1 prlntm:l laOOlIns, fer rl1ft'ginratfon and fer 'IIfl'/ ather 1Ictien that pertaiM to a l!f1%Hic**~~rtaltr-!£r%, ~~**  This £«:tloo is m!. 12 

## t:t used for n r$ <lfPllcation fQ4' reglstr-ation• • 1.**~Jh:t (\'f~ission**  - Check the npptlcabte MlXk MId prcvitkt the A!};ency tetter date if apProprlllte. Pr,wide a brief

u"-IhmatlQfl oi 'he purpose{s) for the Ilubliission, sueh as uthe <ldditioo of G site, pest or crop (sp<U:ify)";**II~** the

•**Cenf)OOnti~·St&t/!lOOrlt** of formula by•••";**"rere!lh~traden** lR.ibmission"; !lfUWral lnbet revision of U$C d!r;x:tions." Atta;::h

.... III**"~;Jilratl:** 

### l'l1e if additIonal**s~e** is Mmfud• 

# • • •**~IQU·Cl** 

## (Packaging 

## and Container Information)

- 1his SectlOO !l¥J$t IX: cct;?letoo for nil**'~.¥:lItiont·l'~ittGd** in COOIl('ctlon**~fth** MW reghtratlen or lIf'Ptfcabte**~ts.**

1. Type of**~il'l9 ~**  Check the ewropriate block if your Pf'ocluct**~ill** txl packaged in the ind!eat¢d packaging**type~.** iwa!\:ilte (\Ie sJUt of the indlvil.k.ml packets and f\lJ!ixor per rhtalt contlliMr. 2. Type of JtctaH Container**~** lndicl1t(! type of t:ontnlMr in l4hich product IIHt be marketed. 3. locatfott qf ltet contents

- Sp.u;lfy thl)' net Cmlt(flt!l of all retail centaiMrs for your pNlduct. 4. Si:r:c(s) of fl:etlilH CoI'ttajou

- Spolclfy**th~** Mt coottmt;; of alt retail contaiMrs fQr yotIr produet. 5. locatfoo of Use nirectlQr'$**~** Indicate the location of the LIGC directions for '{Otlr product. 6.**~** in which [abel is affixed to prcdJet

- Indican the Mthod prodJct labet is attaclted to retail container. 

## SECTION 

## IV (Contact Foint)

- Thi!). SeetiM ItWt be**c~leted** for aU eppl\cutiom. for Regi$trlltion 3cticns, I.e., new prodlxt$**r~l$tration.** r«ub!lln:ion.**~me-too."** feregi$tNltien, etc. l-S,**sett~explenatorY.**

6. EPA Use Onty. 

# 185

# • •

DATE: 

# if

- J

# 2

-

# f'J TQ: FILE ROOM
__________________ _ DOCUMENT CENTER
________________________________ _

# ~DUCT MANAGER 

## -'.,)""-',,1""-
___________ _ PAM (ROOM 263)
FROM:

# taz~ TYPE OF REGISTRATION FAST

- TRACK ACTION (with data/without data) This action has been detennined to be a fast-track action 

## by FEPS and**~** 

## be entered in the PRATS using one of the following codes: 160

- Application for lime-toil registration 170

- Application for registration

- old chemical

- "Metoo" 

## with additional use. 300

- Amendment

- label revision

- administrative (no data required). 

## 305

- Amendment

- label revision

- data required does not need HED/EFED review. 310

- 

### Amendment

- added "me-toon Use

- no HEDjEFED review 

### needed. 

## 345

- Formula change

- no HED(EFED review required. REGULAR REGISTRATION (with data/without data) 

### HC NEW
24C AMENDMENT 

## RESUBMISSION (response to Agency Itr) FINAL PRINTED LABELS

# ~ER MESSAGE:
______________________________________________________ _



# 186

# •

• Mr. Warren A. Davis Rhone-Poulenc Ag company P.O. Box 12014, 2 

## T.W. Alexander Drive Research Triangle Park, 

# He 27709 

## Dear Mr. Davis: Subject: Food Additive Petition 1H5603 Prep Plant Regulator EPA Registration No. 264-418 Your Submission of 11/15/90 The Chemistry Branch, Tolerance support, Health Effects Division has completed its review of the subject food additive petition, recommending against the proposed amended tolerance of 4ppm for ethephon on cottonseed. You may refer to the enclosed copy of their report dated 11/25/91, for a detailed discussion of their analysis.

Encl'osure sincerely yours,

Cynthia Giles-Parker Product Manager (22) Fungicide-Herbicide Branch Registration Division (H7505C)



# 187

# -.

• .. UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 204&0


# iWV 25 1991 Memorandum O..-I"ICEOI" I'I!;$TICIDII

.....ND TDXJt;; SU.STANCh



## SubJect:

From:

Througb: 

## FAP#IH5603: Response 10 

## Dala Call-In: Ethephon (Prep) 

## In and/or On 

## RAC Cottonseed (Amendment ofExisting Tolerance) and Processed 

## Cottonseed Commodities Refined Oil, Meal, and SoapslOck (New Food/Feed Additive Tolerances). MRID# 41704501; OEnN 7476; OPBarcode 0159333. Robert Lascola, Chemist I.....? 4' 

## Chemistry Branch, Tolerance Support 

# '-fH>O\cW«KA

## Tolerance Petition Section ill 

## Health Effects Division (H7509C) ;; P.V. Errico, Section Head ,,()

# J:,**~** Chemistry Branch, Tolerance Support 

# {I' / Tolerance Petition Section ill 

## Heallll Effects Division (H7509C)
To: Robert**T.ylor~;.Alleo,**

## PM25 FungicidelHerl>icideBranch Registration Division (H7505C)

Rh6ne-Poulenc Ag Company of Research Triangle Park; NC, submitted a petition dated 

## November 15, 1990 in partial response to requirements contained in Ille 1988 Oala Call-In Notice ofthe Elllepbon Registration Siandard. Specifically, an increased tolerance is proposed forelhephon [(2-d11oroelhyl)phosphonicacid] onIlleraw agricultUralcommoditycoltonseed(4.0 ppm; !he

## existing tolerance is 2.0ppm, see PPIOF2312) and new tolerances are proposed for Ille processed commodities meal 

## (24 ppm), refined oil (8 ppm), and soapstock (16ppm). The studies containing !he 

## relevant data 

## have been submitted previously (MRID# 

## 41704501 for cottonseed; MRID# 

## 00030190 and 

## 00122423 for processed commodities). Tolerances for residues ofethephoninion a wide range offood/feed commodities and

## ruminant tissues and milk

## are currentlyestablished under40CPR §

## 180.300. Foodadditivetolerances are established uoder 40 CPR §lSS.27oo for ethephon 

## inion harley and wheat milling fractions, except flour (5 ppm) and sugarcane molasses (1.5 

## ppm). An 

## experimental use permit for ethephon residues on sugarcane molasses 

# appm) expired July 14, 1988. Feed additive tolerances

# are established under40 CFR§186.27oofor ethephon infon 

## harley and wheatmilling fractions, except flour (5 ppm), sugarcane molasses (1.5 ppm), a1d raisin 

## waste (65 ppm).



# 188

### t



# •

• -- 

## ------ --

- 

## I



## 2 Toletances are pending for sugarcane (0.2 ppm), sugarc3!le molasses (3.0 ppm), and bagasse (0.25 

## ppm) 

## (pP#OG3840/FAPNOH5595). Application to cotton accounts for approximately 89% of U.S. ethephon usage (preliminary QuantitativeUsage Analysis ofEthepbon, J.E. Hogue, EAll, 

## BUD, OPP, EPA, Jannary 1988). Ethephon is the subject of a Registration Standard dated 

## 3/31/88, an addendum concerning AdditionalDataRequirements forMooochloroaceticAciddated 

## 5/24/88, theEthephon Guidance Document 

## dated 9/88, 

## and a Registration Standard Update dated 2/13/91. 

## The relevant data requirements addressed ill this petition can be 

## found on page 22 ofthe Update:
The current approved labeling for etItepbon on cotton specifies a

## total application rate of3 Ib 

## ail A1season. Data are required depicting residues ofetltephon 

## and MCAA (monochloroacetic acid) in or on cottonseed harvested 7 days after the last 

### oftwo applications using arepresentativeEC formulation. Ooe treatment should 

## be made at 

## lib ailA 

## when 50% ofthe bolls are open, followed by asecond troatmoot 4 

### days later at 2 Ib ai/A. Application should be made by 

### aerial equipment in 

### 2 gal 

## water/A and (in separate tests) ground equipment in 

### 15 gal 

### water/A. 

## Tests must be conducted in

## AZ (7%). AR (7%), CA (18%), GA (2%), MS(12%), NM(1%), OK (2%), and 

## TX (35%) which accounted for approximately 84% of 1988 U.S. cottonseedproduction (Agricultural StatUti

... 1989. p. 108). Alternatively. the registrant must propose increasing the 

## es.tablished tolerance for residues of ethephon in 

### or on cottonseed from 2 

### ppm to 

### 4 

### ppm, 

### and must amend all pertinent product labels to 

### reflect anwcimum allowable use cateof2 Ib ai/A/season for application ofethephon to 

### cotton. When an appropriate tolerance for residues in 

### or on cottonseed is determined. 

## foodJfeed additive tolerances must be·proposed. Based on acceptable data from a cottonseed study, ethephon residues concentrate up to 2x in refined oil and 

### up to 

### 6x in cottonseed meal. 

## [The 1988 DCI also 

## called for proposal of tolerances of 4x in soapstock, but as noted in the 

## Updatereview of

## residue concentration studies showedthatethephon residues didnotconcentrate in soapstoclc. The establishment ofan ethephon soapstock food/feed additive tolerance is no longer required.]

Conclusions 1. The nature of the residue 

## in plants is understood. The residue ofconcern is the parent compound, ethepbon. Cottonseed samples must also be 

## tested for levels of monochloroacetic acid (MCAA). 

## 13. The nature ofthe residue in 

## ruminant animals is understood. The residue ofconcern in 

## ruminant tissues and milk is the 

## parent compound, ethephon.



# 189

### f



# •

• 3 

## 2b. Apoultry metabolism study has been required in the efhephon reregistration standard. Because cottonseed processed products make up a small portion ofpoultry diet, and 

## ethephon is already 

## registered in cotton, any revisions in the nature ofthe residue in poultry ClI!l 

## be addressud in 

## the rercgi'trationprocess. 3. Both analytical methods (forethephon andMCAA) arc valid for gathering residue data.



## 4. However, both 

## also use the hazardous chemical diazomethane as a methylating agent. 

## The reregistration update states that these methods should be 

## revised to use a safer methylatiag agent, and compiete validation data must be 

## submitted for the revised methods. If

## use ofa suitablealternativeis impractical, documentation should be

## provided supporting Ute need 

## for diazomethane. Because this pedtion requests increasing Ute established tolerance for a registered use, we have no objections to having this issue addressed in 

## Ute reregistration process. There is an enforcement method available in PAM II for cottonseed

. The manufacturing process is understood. 5. The petitionerhas appropriately amended Ute label to meet the requirements ofUte Registration Standard Update.
6. CBTS condudes Uta!

## Ute storagestability studies arenotadequate for Utepurposes ofthis tolerance request. Thepedtianermust submitstorage stability data

## reflectiag Ute storage times ofUte samples which were used to generate Ute 

## residue data. Also, Utepetitioner must submit storage stability data for MCAA stored overa similarperiod oftime.
7a. Pending submission ofadequate storage stabilitydata, Ute submitted residue data support theproposed amended tolerance of4ppm for eUtephon on cottonseed. Also, application ofethephon to cottonseed does not result in an increase ofMCAA residues above naturally occurring levels. No tolerances for MCAA 

## in cottonseed are necessary at this time. 7b. Upon processing, ethephon residues do notconcentrate inoil butdoconcentrate

## in meal. 

## Therefore, food/feed additive tolerances are not required for ethephon on refined oil or soapstock. The pedtioner should submit a revised Section F requesting a food/feed additivetolerance of 1.25. 

## (5 ppm) for residues ofeUtephon in cottonseed meal and deletiag lbe FAT's for refined oil and soapstock. 8. AgencypolicywiUt respect to possible tolerances in meat, milk, and eggsresultiag from this proposed use is delineated in 40 CPR §

## 18O.6(a)(2). Tolerances which have 

## been established on meatandmilkareadequate tocoverthis increasedtoleranceoncottonseed. Any revisions in the assessment ofUte need for tolerances inpoultry tissue and eggs can be 

## addressed in Ute reregistration process. 9. There are no Codex, Canadian, or Mexican tolerances for ethephon established 

## inion



# 190

# •

• 4 

## RAC cottonseedorprocessed cottonseedproducts. Therefore, there areno compatibility 

## problems involved in this petition.

Recommendations
CBTS recommends against the proposed amended tolerance of 4 ppm for ethephon on cottonseed for the

## reasons delineated in Conclusions 6 and 7b. 

## As discnssed in Conclusion 7b, 

## CSTS also recommends that

## arevised food/feed additivetolerance of5ppm should 

## beproposed 

## for cottonseed. meal, but such tolerances are not necessary for the processed commodities cottonseed oil and soapstock. AdditionalComment:Thereviewedresiduedata shows thatMCAAmay naturally

## occuratlow levels in

## mes. This conttadicls 21 CFR §189.155, which states that MCAA does not naturally occur and that 

## any item with detectable MCAA residues is 

## adulterated. Confirmation ofthe identity ofthe ohserved residues and resolution ofthe apparent conttadiction is not within the 

## purview ofthi.memo. However, at 

## afuture point the suilllbility of21 CFR §189.155 may need to 

## be reevaluated.

Detailed Considerations ManufacturingProe

... The manufacturing process is detailed in the Product ChemistIy Chapter of the Regislration Standard. Ethephon 87.3% technical is registered under EPA Reg. 

## No. 264-276. CBTS 

## concludes that the manufacturing process is understood.
An impurity in ethephon, the monochloroethyi ester of (2-chloroethyl)phosphonic acid, 

## can theoretically degrade tomonochloroacetic 

## acid (MCAA), anextremelytoxic metaholic inhibitor. Under 21 

## CFR §189.155, MCAA has 

## been prohibited from addition to food. An addendum to 

## the Residue ChemistIy Chapter ofthe Ethephon Regislration Standard (see 

## D. 

## Edwards memo of5/24/88) 

## required 

## dataforMCAA for food and feed crops for which other datawere needed, including cottonseed. Aproposed 

## waiver for MCAAtesting incertain commoditins was 

## denied (see 

## D. 

## Edwards memo of 1112/89).
Proposed 

## Use The formulation proposed for use is Prep, which contains 55.4% active ingredient (6 lbs. ethephonlgallonEC formulation) (EPANo. 264-418) andis used forhothpreconditioningcotton plants for defoliation and promoting hoI! opening. The following useinformationis submitted:



# 191

## Expected Conditions 5-7 Dan After

# Treatment BOLL OPENING Hot and 

## Dry, 80 For higher Dry, 75 F

- go 

## F Cool buthigher than 6S F Rank 

### cotton 

## PRECONDmONING FOR DEFOLIATION Hot and 

## Dry, go 

## Forhigher Cool but higherthan 65 F; 

## also for rank 

## cotton 5

Amount Obs ailA)

1.0 

## I.5 2.0 2.0

0.5 1.0 Spray

## Volume (gallA) 

## Ground 

# rue

IS-50 IS-50 IS-50 25··50

IS-50 IS-50 

## 2-5· 

## 2-S· 2-5· 5

2-5· 2-5*

• ,. For CA, AZ use avolume ofno less than 

## 5 GPA for aerial applications.



# • Do not exceed a maximum of2 Ibs **ail** 

## A for the combined use as a preconditioning treatment 

## for defoliation 

## and cotton boll opening. 

## Do Dot

### make more than two applications to 

### anyone cotton crop. For boll opening, apply when there are sufficient mature opened bolls to 

### produce the desired 

## yield, but not

## later than when 60% ofthe bolls are opened. For preconditioning for defoliation, 

## apply either 4-7 days prior to 

### application ofdefoliant or tank mixed 

## with defoliant. Do 

## not harvest cotton sooner than 

## 7 days after atreatment with Prep 

## PlantRegulator. 

## CBTS concludesthat

## thepetitionerhas appropriately amended thelabel 10 meettherequirements of the Registration Standard Update, which states that if 

## the petitioner chooses 10 propose increasing the established Iolerance for residues of ethephon in or on cottonseed from 2 10 4 ppm, he must also amend all pertinent product labels 10 

## reflect a maximum allowable use rate of2 Ib 

## aUAfseason for application ofethephon 10 cotton.

Nature ofthe Residue· Plants 

## No additional metabolism studies were subntilted with this petition. Previous radiolabeling studies ("C-labeled ethephon applied 10 grapes, cantaloupes, apples, and cherries, and "C- and "P-Iabeled ethephoo 

## on pineepples

- see PP#2FI275; 2GI217, IGl172, and IFlOl6) have shown that the only 

## degradation products are ethylene gas and simple phosphate and 

## chloride ions, which are taken up inlo the natUIal metabolic pathway oftheplant. Asimilarmetabolism has been demonstrated on three 

## differentcrops. Theresidue ofconcern is theparentcompound, ethephon. The Ethephon Guidance Document (pp. 14-16) has stated the concern that the residues of monochloroacetic acid (MCAA), a theoretical degradation product of an impurity



# 192

# •

• 6 (monochloroethylesterof[2-chloroethyl]-phosphonic acid) in technical ethephon, may be found in ethephon-treatedcommodities. MCAAis anextremely toxic metabolic inhibitorandhas been 

## prohibited from addition to food under 21 CFR §l89.155. Analysis of certain food and feed 

## crops, includingcottonseed and relatedprocessed products, forresidues ofthiscontaminantwere required. The data for cottonseed has heen submitted and is reviewed below (see 

## Magnitude ofthe Residue

- Field Study). CBTS concludes that 

## the nature ofthe residue in plants is 

## understood for the purposes ofthis 

## tolerance increase request. The 

## residue of concern is the parent 

## compound, ethephon. Cottonseed samples must also be tested for levels ofmonochloroacetic acid.

Nature oftheResidue

- Animals 

## No additional animal metabolism studies have heen submirled. The Registration Standard Update has stated that the nature ofthe residue in ruminant tissues and 

## milk is 

## known. Studies have determined the metabolism ofethephon in cattle rumen and in a goat. Details 

## of these studies are presented below. In 

## an in

## vitro 

## study (see 10128183 memo ofK. Ame in PP#2F2711), rumen contents were taken 

## from a fistulated steer, buffered, and charged with 

# "c labeled ethephon to a level of40ppm in a flask thatvented to a mercuric perchlorate ethylene trap. At a pH of6.4 and temperature of 38.4 ·Cthehalf·lifeofethephon inrumen was found to be, 

## in three 

## identicalexperiments, about 6 hours. After 18 hours, 85-90% ofthe 

# "c label was 

## recovered from the ethylene traps. Of the residual activity in rumen 

## after 0, 1,2, or 6 hours, 72-104% was accounted for, by Ge. 

## as 

## ethephon; the proportion ofresidnal activity accounted for as ethephon did not decrease with time. 

## The viability oftherumen contents was 

## demonstrated by following the productionoffatty acids (acetic, propionic, and butyric), which was shown to increase with time. (Volatile fatty acid production is associated with cell growth and gas production.)
In the goat metabolism study (see

## 6/29/84 

## and 11128184 

## memos ofK. Arne in PP#2F2711), two lactating goatsreceIved daily doses of,'(; labeled ethephon equivalent to 10 ppm in the dietfor 7 days; a third goat served as a contrO\. Urine, feces, 

## milk, and blood were sampled daily; volatiles were collected for a 24 hour period .OD 

## the 7th day. Goats were sacrificed approximately 16 hours after the final dose. Residue analysis is outlined below. Milk: 

# "c activity reached a plateau on Day 4. Recovered activity was 

## 3% ofthe 

## total dose. Ofthis, 45% went to 

## milk filt. Ethephon is water soluble, thus the residues found in milkfat correspond to metabolites. TI.C and HPLC analysis of these residues determined that the activity was taken 

## up into nalural products. Of the aqueous activity, ca. 30% degraded to ethylene on treatment 

## with base, indicating that this material had been the parent compound,**et~ephon.**



# 193

# •

• 7 liver: 

## The observed activity corresponded to 1.2 ppm ethephon equivalents. No ethylene gas was produced on base 

## treatment, meaning no etbephon was in the liver. Protein released 

## by treatment with trichloroacetic acid 

## contained 12.4% ofthe total activity. A 

## small amountofthe activity was found in glycogen Utathad 

## been isolated from liver, but only 9

## mg had

## beenisolated from 10 

## g of liver; apparently glycogen levels had 

## been reduced by Ute stress of dosing, confinement, and sample collection. Ofthe total activity in liver, 5.3% partitioned into ethyl ether, 63.7% into methanol, 5.3% into liver, and 27.2% remained in the solid tissue. The activity was net further characterized. Kidney, 

## Muscle, and Fat: 

## Recovered kidney, muscle, and fat activity corresponded to 1.18, 0.1, 

## and 0.5 

## ppm ethephon equivalents, respectively. Ofthis, 8.5 

## ppl1 

## ofthe kidney activity degraded to ethyleneon base treatment; similar treatment ofmuscle and fat tissues produced no ethylene. The activity was not otherwise characterized

. Other: Of

## the total activity, 31%

## was trapped as Co, and ethylene volatiles, 7% 

## was found in the feces, and 19% was found in the urine. Of the latter, 36% was determined to be ethephon, with 

## the remainder postulated to be a glutathione adduct (with the sulfur displacing the chlorine).
From this information it 

## is determined 

## that the fate ofethephon in ruminant metabolism is 

## generally degradation into ethylene gas, CO" and natural products. There isan outstanding dnta gap with regards to Ute nature oftheresiduein poultry, as 

## initially outlined in the Registration Standard. However, since cottonseed meal and crude oil constitute 

## only a minorportion ofpoultry feed (:S 

## 10%), 

## and there is already 

## aregistration on coHon, the fulfillment ofthis 

## data gap 

## can be addressed in the reregistration process. CBTS concludes that the nature ofthe 

## residue in ruminant animals is adequately defined for the purposes ofthis tolerance request. .The residue ofconcern in ruminant tissues and milk is the parent compound, ethephon.


## Analytical Methods 

## All samples were analyzed 

## for ethephon residues by 'Ethephon

- Detailed Method ofAnalysis for Residues of(2-Chloroethyl) Phosphonic Acidin COUOnseed, Cottonseed Hulls, Meal, 

## Oil, 

## and Soapstock' (SOP90075; performed byMcKenzieLabs, Inc., Phoenix, AZ),

## submitted with MRID# 417045-111. The method is essentially identical to Method I, PAM IT, 12/31174. The sample is freeze-dried and ground, soxhlet extracted with methanol and pH adjusted with 10% 

## HCI inMoOR. Diethyl etheris added to precipitateany interfering materials, anddiazomethane is added to methylate the ethephon. Quantification is achieved by GC, using either a flame photometric detector in thephosphorus mode or an alltaIi flame thermionic detector. 

## McKenzie Labs validated the analytical method by analyzing 0.02, 0.20, and 2.0 ppm spikes ofcottonseed in triplicate. Recoveries ranged from 70

- 113% with an average of 86 

# ± 14.3%. The



# 194

# •

• 8 

## validated level ofqlWltification is 0.02 ppm. Aconfirmatory method, Method A in PAM lJ, 

## distinguishes ethephon from otherpesticideinterferences. An alkali thermionic detector is used 

## to detect residues containing phosphorus (including ethephon), and a microcoulometric (Hall electrolytic) detector is used to distinguish halogen-contai'ling pesticides (including ethephon). MethodIhas been held acceptab:efor enforcementpurposes for cottonseed atalevelof0.1 ppm (see L. Bradley memo of6/3/90, 

## PPNOF2312). Union Carbide submittoo a GC method for the determination ofethephon residues in milkand cattle tissue (1984; MRID# OOI4226S). The method was subjected to a method tryout (1984; PP#2F271IIFAP#2H5357; RCB Request to COB, 915/84, 

## K. Arne; Results ofMethod Trial Memo, 1128/85, K. Arne) on cow milk

## and liver fortifioo with ethephonat0.1

- 0.2 ppm. For milk, recoveries ranged from 68**~** 

### 74%, 

## with one outlier at 48%. 

## For liver, recoveries ranged 

## from 98

- 128%. The method is adequate for both data collection and enforcement purpnses, although it does require two days to complete a set of samples and does require on-column capillary column capability (COB Memo, 117184, 

## D. Wright, Jr.). The method was submitted (2/87) 

## for publication as Method III in PAM II. As noted in the September, 1988 Ethepbon Guidance Document, representative plant samples, ruminant tissues, and milkbearing residues ofethepbon must be 

## subjected to analysis by PAM Vol. I methods 211.1, 212.1, 231.1, 232.1, and 252. Data has been 

## submitted by RhOnePoulene (1988, MRID# 412962-01) and forwarded to 

## FDA for review and inclusion in PAM Vol. I (see W. Smith memo of 11!2/90). 

## The petitioner bas also submitted. method for determination ofMCAA residues, "Detailed Method ofAnalysis for Residues ofMonochioroacetic Acid inaVariety ofSampleTypes' (SOP 9OOSOm, with modification at RhOne-Poulene 

# in Research Triangle Park, NC). The method consists ofgtinding the sample, extracting the sample with methanol, the addition ofwaterand NaOH to 

## the extract, extract cleanup by an ion-exebange column using QAE SEPHADEX" A 25 resin, cleanup using aSEP-PAK'"CII

## cartridge, extractionoftheaqueous solutionwithether, methylation oftheether solution, minimal dilution with hexane, and final quantification by GC with electron-capture detection. Recoveries of0.01 ppm spikes ranged from 52

- 95%, with an average of69.5 

# ± 13.1%. The lowest demonstrated limit ofdetection is 0.01 ppm. CBTS concludes that 

## the analytical methods for detecting ethephon and MCAA are valid for gathering residue data.. However, we note that both also use diatomethane as a methylating agent. As 

## stated in 

## the Reregistration Standard Update, "the carcinogenic and explosive potential ofdiazometbane puts FDA enforcement personnel at 

## risk; thus the registrant should 

## revise these methods using a safer methylating agent. Complete validation data must be 

## submitted for the

## revised methods. Ifuseofasuitable alternativeis impractical, documentation should be

## provided supportingthe need for diatomethane." (Footnote6) 

## Wehaveno objections to having this issue addressed in 

## the reregistration process.



# 195

# •

• 9 Storage StabUlty
In

## response to the Ethephon Guidance Document, the petitioner has submitted interim storage stability study datadepicting ethephon levelsin fortifiedcottonseed samples (MRlD1I41668215). Cottonseed samples were homogenized and analyzed to confirm the absence of apparent ethephon; thehomogenized samplewas portioned into analytical sets offour sampleseach. Each set contained two samples spiked with 1.0 ppm analytical grade ethephon (while the samples were still fresh) and two unspiked samples (one used as a control and the other as an analytical method spike). One setwas 

## analyzedpriorto storage, providing zero-timedata; the others were frozen at 

## ·20 'C. Samples were removed from storage and analyzed at 

## intervals of 1, 2, 4, and 6 months. The analytical method used was identical to the method discussed above (see AnalytkaI

## Method). Method validation results showed an average recovery of90 

# ± II%

## for spikes of0.05, 0.20, and 2.0ppm over 3 days. The demonstrated limit ofdetection was 

## 0.05 ppm. Results ofthe analysis are presented in Table 1. 

## Thedata indicatethat levels ofethephon do notsignificantly decrease over a 6 month period in cottonseed.

• 

## , Table 1 Storage StabilityAnalysis' Percent Recoveries Storage Stabmty Method Sample (months) 

## Control Spike Sample I 

### Sample 

## 1 Avg. 

### 0 

# NDt 92 82 93 

## 87.5 I 

### NO 108 

## 82 91 

## 86.5 

## 2 NO 108 

## 82 91 

## 86.S 4 

### NO 108 

## 93 76 

## 84.5 

## 6 NO 

## 96 90 

### 76 

## 83.5 

## t Not 

### Dotected. 

## CBTS conclodes that 

## the storage stability studies are not adequate for the purposes of this tolemoce request. The residue data submitted was generated after storage intervals of208·350 days, longerthan 

## the -180day interval shown in the storage stability studies. Given the small numberofspiked samples analyzed (10 total), CBTS is 

## reluctant to extrapolatethe existing data to covera 12·month storage period. Therefore, thepetitionermust submit storage stability data reflecting the storage times ofthe 

## samples which were used to generate the residue data. Also, no data has been 

## submitted concerning the stability ofpossible MCAA residues in cottonseed. Tests for MCAA residues were conducted 225·309 days after harvest. The petitioner must submit storage stability data for MCAA over a similarperiod oftime.



# 196

# •

• IO
Magnitude 

## oftheResidue

- Field Study 

## Thepetitioner submitted the study 'PREP/Cotton/Residues" (1990; MRID#41704501). In this study, data was collected from 18 aerial application tests (conducted in AR, AZ, GA, MS, OK [two each), CA, and TX [four each)) and 20 ground application tests (conducted in 

## Alt, AZ, CA, GA, NM, OK [two each), MS, and TX [four each)). The pesticide used 

## was Prep (6 Ib ailgal EC formulation). These states account for approximately 84% of the 1988 U.S. cottonseed production (Alnicultural Statistics, 1989, p. 108) and thus represent adequate geographical representation. At each site, two treatment schemes were tested. 

## The 

## first schemeinvolvedapplication at arate of0.5 Ib ailAfollowed 4days laterby 1.5 

## lb ailA; the second consisted ofa single application at 2.0lb ai/A. 

## In almostall trials thefirst application 

## was atapproximately 50% boll opening• Sprayvolumesfor aerial

## applicationsranged from 1.98

- 5.4gailAusing commercially equipped fixed-wing aircraft 

## orhelicopter. Spray volumes for ground applications ranged from 11.5-20 gailAusing commercial sprayers or Co,backpaok sprayers. Both volumes used are consistent with the label directions (2-5 gal/acre aerial. 15-50 gal/acre ground applications

- for only one ground application trial did the volume fall below 15 gal/A).
Mature cottonseeds were harvested 7, 10-11, and 14 days following treatment. Samples from one harvest 

## interval at 

### five locations were air.-.dried 1()"24 hOUTS, 

### and samples from one harvest 

## interval at

## three locations were air-dried 2.5-4 hours before entering cold storage; samples from one harvest interval at two locations underwent additional air drying upon receipt at Rb6nePoulenc. Samples were stored on-sitefor intervals of 1-81 days at 

## temperatures ranging from 

# o ·C to -26 

# ·c, and were packed in dry 

## ice for shipping via either overnight express or refrigerated truck; in transit time ranged from 1-34 days. laboratory storage 

## was ,.-15 ·C. Total storage intervals ranged from 208-350days betweenharvestand sampleextJ:actionand 1-9 days between extJ:action and quantification for ethephon.
Three replicate 

## treated samples and one untreated control were collected from**~h** 

## site, 

## generating a total of 342 samples and 57 controls which were tested for ethephon residues. Residue values were corrected for recovery efficiency (as determined by recovery ofa 0.2ppm spiked sample, analyzed separately. Average recovery was 85.0 

# ± 12.0%). Asummary ofthe test data is presented in Table 2. Generally, the magnitude

## oftheresidues obtained from ground application

## was higher than 

## that from aerial applications (although the 

## difference is not statistically significant due to the large range ofthe residue values), There was no significant difference in the magnitude ofresidues found in crops harvested at different PIDs. Seven samples from two different trials contaln ethephon residue levels abovethe current2ppm tolerance, ranging as high as 3.6 ppm. The 

## data are consistent, however, with the proposed tolerance of4 ppm.



# 197

# •

• 11 Table 2. Summary ofResults ofEthephon Analysis 

# pm Rate 

### Applieatlon 

### Residue Residue (day.) 

## Obs aliA) Method Avg. (ppm) Range (ppm) 

## 7 0.5 

## + 1.5 

## aerial .24 

# ± .24 .02

- 

# .83 ground 

# .64 ± .51 .ll

- 

## 2.0 2.0 aerial 

## .32 

# ± .26 .02

- 

## 1.0 groond 

# .69 ± .70 .05

- 2.9 1()'11 0.5 

## + 1.5 

## aerial 

# .33 ± .33 .02

- 1.4 ground 

## .53 

# ± .51 .04

- 

## 1.6 2.0 aerial 

# .35 ± .39 .02

- 1.5 ground 

# .60 ±.64 .04

- 

## 2.7 14 0.5 

## + 1.5 aerial 

## .24 

# ± .30 .02

- .96 groond 

## .61 

# ± .79 .02

- 

## 3.6 2.0 aerial 

## .37 

# ± .52 .02

- 

## 2.0 ground 

## .55 

## ± .66 .02

- 

## 2.4

Cottonseed samples from four trial sites (AZ(2), MI, GAl were also analyzed for residues of monochloroacetic acid (MCAA). Two aerial and two ground application tests were run, with PHIs of7, 10-11, and 14 days. Pre-analysis sample storage conditions were identical to those for the samples analyzed for ethephon (storage intervals ranged from 225-309 days). The test results showed application ofethephon did not cause any apparent increasein MCAA residues. Average detected levels were reported as 0.0053 

# ± .0029 ppm for control samples and 0.0056 

## ± .0034 ppm for 

## treated samples (both 

### values corrected for recoveries, see Analytical 

## Methods). Reported residue levels in treated samples were not seositive to the method of application orPHI. CBTS is 

## not convinced ofthe reported precision of the apparent MCAA residue levels. The demonstrated limit ofdetection is 0.01 ppm. No standard curves were submitted that would allow evaluation oftheappropriateness ofreporting MCAA residues attheppl! level. However, evaluation ofthe submitted chromatograms shows that the relativeamounts ofapparent MCAA residues can be 

## determined, and based on this data, MCAA residues in cottonseed are not enhanced by the application ofethephon. [We note that there are problems with the rule concerning the regulation ofMCAA (21 CFR §

## 189.155). Subsection (a) states, in part, "(MCAA

# 1 is a synthrtic chentical not found 

## in naturn!



# 198

# •

• 12 products

..." and subsection (b) 

## states 'Food containing any added or detectable level of monochloroacetic acid is deemed to be adulterated

...'. However, the submitted dataindicates thatMCAA residues could occur naturally inRAC's. The cottonseed results are 

## reinforced by the dataon MCAA residues inblackberries andcantaloupes which were submitted inconnection with the 1988 Ethephon Guidance Document (MRID# 

## 41668205 and 41668207). In these studies, naturally occurring low 

# « 10 ppb) levels of apparent MCAA residues were also found. It

### is 

## likely that this rule reflects the capability ofthe analytical methods at the time it was written, when MCAA residues below 10 

## ppb could not be detected. Further studies (GClMS, for example) could now be

## doneto determine the identity ofthe compounds thatelute at the MCAA retention time. For the 

## purpose ofthis petition, such studies 

## are not necessary. However, they may be necessary in the future, and at 

## that point the suitability of 21 CFR §189.155 

## will need to be evaluated.] Pending submission ofadequate storage stability data, CBTS concludes that the submitted data supporttheproposed amended tolerance of4

## ppm forethephononcottonseed. Also, application 

## ofethephon to

## cottonseed does notresult in anincrease ofmonochloroacetic acid residues above naturally occurring levels.

Magnitudeor

## theResidue

- 

## Processing Study 

## No data concerning the concentration ofethephon residues upon processing ofcottonseed are submitted with this petition. However, two studies have been submitted previously by Union carbide 

## Agricultural Products Company. In the first (1978; MRID# 

## 00030190), cottonseed was harvested 6-21 days after a single application of ethephon at 2 Ib ai/A at sites 

## in NM(!), OK(I), and TX(2), among others. Observed ethephon residues in these samples ranged from 0.03

- 1.4 ppm. Control values ranged from <0.01 ppm, theimplied limit ofdetection, to 0.07ppm. Replicate samples were composited prior to testing. Samples were analyzed using an adequate GC method, with demonstrated recoveries of70-108% for 0.10ppm forrified samples. Portions ofthe cottonseed samples from these trials 

## wereprocessed intohulls, meal, crude oil, refined oil, and soapstock. 

## The results ofthese tests 

## are summarized in Table 3. These data are intetpreted in

## the 2113/91 Update to signify that ethephon residues concentrated in cottonseed meal (6<) 

## and refined oil (2x) and did not concentrate in hulls, crude oil, and 

## soapstock. However, upon further consideration CBTS considers this conclusion incorrect. There is reason to be 

## suspicious ofthe NM and TX(2) trial results, as the cottonseed samples bore residues within therange ofresidues found in the control samples. Since determination of the concentration factor involves dividing by this uncertain and smull number, unreliable and large concentration factors are likely to result. Furthermore, it is theoretically impossible for residues to concentrate in both meal and oil, as they represent the two main 

## components of cottonseed. Since ethephon is highly water-soluble, and is claimed to be 

## unstable in 

## base, one 

## would expect any concentration to 

## occur in the meal. But, if

## the oil com:>rises approximately



# 199

# •

• 13



## Table**3~** 

## Concentration ofethephon residues on processed cotton products. !Values represent Ill!m ethOlihon 

# residuW

NM OK TX(I) TX(2) 

## Cottonseed 0.03 

## 1.4 0.15 0.03 

# .-. 

# --_._- ._-_._- Hulls 0.02 0.8 0.03 <0.01 (Conc. Factor) (0.67) (0.57) (0.20) (-) 

## Meal 0.18 1.29 0.18 0.19 (Conc. Factor) (6.0) (0.9) (1.2) 

## (6.3) Crude Oil <0.01 <0.01 <0.01 0.02 (Conc. Factor) (-) 

### (-) 

### (-) 

## (0.67)

Refmed Oil 0.06 0.05 0.01 0.04 (Conc. Factor) (2.0) (0.0) (0.1) (1.3) Soapstock <0.03 <0.03 <0.03 <0.03 (Conc. Factor) 

## (-) (-) (-) (-)



## 113 of the cottonseed (see N. K. Whetzel memo of 

## 12/27179 in the Cotton C.P. File), the 

## maximum possible residue concentration in 

## the meal is 1.5x, not 6x as indicated above. CBTS considers the data generated by the OK and TX(l) trials, in 

## which there is a finite amount of 

## residues in the**non~processed** 

## samples, as more likely 

## to show the potential for concentration. We mustconcludethat this study indicates no concentration ofresidues in oil, and concentration of 1.2x in cottonseed meal. 

## In the other study (1977; MRlD# 00122423), six cottonseed samples from a site 

## in CA were processed into mealand oilfractions. Thesamples had been

## harvested 7-14days aftertreatment with 41b aiJA ethephon. Apparent residues on ",itreated samples ranged from <0.01 ppm, the impliedlimit ofdetection, to 0.08 ppm. Sampleswere analyzed using an adequate GC method, 

## with demonstrated recoveries of67-100% for 0.20ppm fortified samples. Samples were stored at 

## -35 'C for 108-167 days before analysis. The residue data is summarized in Table 4.



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# •

• 14 Table4. Concentration ofethephon residues on processed cotton products. 

## fYalues IeJ)resent Woo eihepbpn residues)

PHI 

## Cotton- Relined (00») 

# - Meal Oil

"{ 

## 0.29 0.20 <O.O! 

## 0.18 0.08 • 

## 0.16 0.13 • 

## 14 0.09 0.10 

## • 0.08 0.08 • 

## 0.15 0.Q7 •
No residue concentration is observed for refined oil samples. The maximum residue 

## concentration observed for meal samples is 1.1x. 

## CBTS concludes that upon processing ethephon residues do not concentrate in 

## oil but do concentrate in 

## meal. Therefore, foodlfeed additive tolerances are not required for ethephon on refinedoil orsoap>tock. Thepetitionershould subntitarevised 

## SectionFrequesting afoodlfced additivetolerance of

## 1.2Sx (S ppm) for residues ofethephon in

## cottonseed meal and deleting the FAT's for refined oil and soapstock.

Meat, Milk, Poultry, and Eggs Tolerances of0.1 ppm havebeen 

## established for residues ofethephon in thefat, meat, and meat by-products ofcattle, hogs, horses. and sheep, and in milk (40 CPR §180.300). No tolerances have been established for ethephon residues in poUltry tissues and oreggs. Ahigh level feeding study for ethephon has been 

## submitted previously (see R. Loranger memo of 6118/82, 

## concerning EPA Reg. No. 264-267, located in 

## the correspondence file of PPKOF2312). Levels of 

## S, 15, 

## SO, and 

## ISO ppm ethephon in the diet were fed for 28 consecutiveday. to

## 3 cows ateach 

## level. No detectable residues 

# « 0.02 ppm) were found in meat for the IS and 

## SO ppm feeding levels. The 150 ppm level feeding study did not result in residues in 

## heart, muscle, fat, orkidney. One liver sample showed0.2ppm ethephon. The 150 ppm feeding leveldid result in trace

## residues in 

## milk. Fiveoffifteen samples containedresidues ranging from 0.10 to

## 0.14 ppm ethephon, five contained detectable levels 

# « 0.05 ppm), and five contained no detectable levels 

# « 0.02 ppm).
A poultry feeding study was summarized in 

## the ethephon reregistration standard (memo of



# 201

# •

• 15 4/19/88). CmcJren. were fed for 28 days at 2S or 50 ppm ethephon. Breast, gizzard, 

## liver, thigh tissues, and 

## egg.were 

## analyzed from the50ppm

## group. Fattissue was 

## analyzed from the 25 ppm dosed group. These residues were reported: eggs, <0.01 ppm: breast, <0.01-0.04 ppm: liver, <0.01-0.03 ppm: gizzard, 

## 0.02 ppm: thigh tissue, <0.01 ppm: and 

## fat, <0.01 ppm. No tolerances have been 

## established in poUltry tissue or eggs. Since cottonseed products constitute 

## a small portion 

## (S10%) of poultry feed, and there 

## is 

## already a registration for ethephon on cotton wehave no objection to allowing 

## thai any changes in the existing tolerances be addressed 

## in the reregistration process.



## Other Considerations
There are no Codex, Canadian, or Mexican tolerances for ethephon established inion RAC cottonseed or processed cottonseed products. Therefore, there are no compatibility problems expected for this petition.

Attachment: Codex 

## sheet.

cc: RF, FAPNIH5603, 

## SF, Ethephon Registration Standanl File, R. Schmitt, R. Lascola, Cire. 

## (7), C. Furlow (PffiIFOD), L. Rossi (H7S08W). 

## RDI: P.V. Errico (11120/91), R. Loranger (11120/91) 

## H7509C:CBTS:CM#2, Room 803C, 557-1478, R. LascoIa:7/24/91 IIJ:Disk2\ETHEPH0N\E5603.TXT



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