4276 Federal Register / Vol. 72, No. 19 / Tuesday, January 30, 2007 / Notices 

Epithelial Cell Line Expressing a Cystic 

Fibrosis Phenotype 

Description of Technology: Cystic 

fibrosis (CF) is a common genetic 

disease that affects the entire body, 

producing thick, sticky mucus that clogs 

the lungs, pancreas, and other organs. It 

is the most common fatal genetic 

disease in the United States, and is 

caused by a mutation in the cystic 

fibrosis transmembrane conductance 

regulator (CFTR). 

Researchers at NIEHS have developed 

a cell line, CF/T43, which was produced 

by infection of airway epithelial cells 

isolated from CF patients with an 

SV40T retrovirus. CF/T43 cells maintain 

the abnormal ion transport 

characteristics of CF while having 

proliferation capability beyond that of a 

primary epithelial cell culture. Key 

features of the CF/T43 cell line include 

the formation of functional tight 

junctions, reduced apical membrane 

chloride conductance, and activation of 

apical chloride channels by calcium 

ionophores but not by cAMP-dependent 

agonists. This cell line may be used for 

elucidation of the mechanisms of CF, 

testing candidate complementary genes 

for correction of the observed CF 

abnormalities, and for developing and 

testing therapeutic CF drugs. 

Applications: Research tool for 

developing new therapies to treat cystic 

fibrosis; Research tool for studying the 

mechanisms of cystic fibrosis. 

Inventors: Anton M. Jetten (NIEHS). 

Publication: AM Jetten, JR Yankaskas, 

MJ Stutts, NJ Willumsen, and RC 

Boucher. Persistence of abnormal 

chloride conductance regulation in 

SV40 T transformed cystic fibrosis 

airway epithelia. Science 1989 Jun 

23;244(4911):1472–1475. 

Patent Status: U.S. Patent Application 

No. 07/368,725 filed 21 June 1989, 

which issued as U.S. Patent No. 

5,420,033 on 30 May 1995 (HHS 

Reference No. E–201–1989/0–US–01). 

Licensing Status: Available for 

exclusive or nonexclusive licensing. 

Licensing Contact: Tara Kirby, Ph.D.; 

301/435–4426; tarak@mail.nih.gov. 

Dated: January 20, 2007. 

Steven M. Ferguson, 

Director, Division of Technology Development 

and Transfer, Office of Technology Transfer, 

National Institutes of Health. 

[FR Doc. E7–1379 Filed 1–29–07; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Cancer Institute; Notice of 

Closed Meetings 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. Appendix 2), notice 

is hereby given of the following 

meetings. 

The meetings will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5. 

U.S.C., as amended. The grant 

applications and/or contact proposals 

and the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications and/or contract proposals, 

the disclosure of which would 

constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: National Cancer 

Institute Special Emphasis Panel, R25 

Special Emphasis Panel. 

Date: February 6, 2007. 

Time: 5 p.m. to 6 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: Washington Court Hotel, 525 New 

Jersey Ave, NW., Washington, DC 20001. 

Contact Person: David E. Maslow, PhD., 

Chief, Resources and Training Review 

Branch, Division of Extramural Activities, 

National Cancer Institute, National Institutes 

of Health, 6116 Executive Boulevard—Room 

8117, Bethesda, MD 20892–7405, (301) 496–

2330. 

This notice is being published less than 15 

days prior to the meeting due to the timing 

limitations imposed by the review and 

funding cycle. 

Name of Committee: National Cancer 

Institute Special Emphasis Panel, Arrays for 

Biomarker. 

Date: February 13, 2007. 

Time: 12 p.m. to 6 p.m. 

Agenda: To review and evaluate contract 

proposals. 

Place: National Institutes of Health, 6116 

Executive Boulevard, Bethesda, MD 20892, 

(Telephone Conference Call). 

Contact Person: Lalita D. Palekar, PhD, 

Scientific Review Administrator, Special 

Review and Resources Branch, Division of 

Extramural Activities, National Cancer 

Institute, National Institutes of Health, 6116 

Executive Boulevard, Room 8105, Bethesda, 

MD 20892–7405, (301) 496–7575. 

Name of Committee: National Cancer 

Institute Special Emphasis Panel; Multiplex 

Affinity Capture Technology. 

Date: February 15, 2007. 

Time: 12 p.m. to 6 p.m. 

Agenda: To review and evaluate contract 

proposals. 

Place: National Institutes of Health, 6116 

Executive Boulevard, Bethesda, MD 20892, 

(Telephone Conference Call). 

Contact Person: Lalita D. Palekar, PhD, 

Scientific Review Administrator, Special 

Review and Resources Branch, Division of 

Extramural Activities, National Cancer 

Institute, National Institutes of Health, 6116 

Executive Boulevard, Room 8105, Bethesda, 

MD 20892–7405, (301) 496–7575. 

Name of Committee: National Cancer 

Institute Special Emphasis Panel; Manpower 

and Training Grants. 

Date: February 27–28, 2007. 

Time: 8 a.m. to 5 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: Hilton Old Town Alexandria, 1767 

King Street, Alexandria, VA 22314. 

Contact Person: Lynn M Amende, PhD, 

Scientific Review Administrator, Resources 

and Training Review Branch, Division of 

Extramural Activities, National Cancer 

Institute, 6116 Executive Boulevard Room 

8105, Bethesda, MD 20892–8328, 301–451–

4759, amendel@mail.nih.gov. 

Name of Committee: National Cancer 

Institute Special Emphasis Panel; Small 

Grants Program for Cancer Epidemiology and 

Cancer Prevention Research. 

Date: March 6–8, 2007. 

Time: 8 a.m. to 5 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: Holiday Inn Georgetown, 2101 

Wisconsin Avenue, NW., Washington, DC 

20007. 

Contact Person: Irina Gordienko, PhD, 

Scientific Review Administrator, Special 

Review and Logistics Branch, Division of 

Extramural Activities, National Cancer 

Institute, NIH, 6116 Executive Blvd., Rm. 

703, MS 2829, Bethesda, MD 20892, 301–

594–1566, gordienoiv@mail.nih.gov. 

Name of Committee: National Cancer 

Institute Special Emphasis Panel, AntiCancer Agents. 

Date: March 15, 2007. 

Time: 11 a.m. to 3 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health Events 

Management, Executive Plaza North 

Conference Center, 6130 Executive 

Boulevard, Conference Room D, Rockville, 

MD 20852, (Telephone Conference Call). 

Contact Person: Jeannette F Korczak, PhD, 

Scientific Review Administrator, Resources 

and Training Review Branch, Division of 

Extramural Activities, National Cancer 

Institute, NIH, 6116 Executive Blvd., Room 

8115, Bethesda, MD 20892, 301–496–9767, 

korczakj@mail.nih.gov. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.392, Cancer Construction; 

93.393, Cancer Cause and Prevention 

Research; 93.394, Cancer Detection and 

Diagnosis Research; 93.395, Cancer 

Treatment Research; 93.396, Cancer Biology 

Research; 93.397, Cancer Centers Support; 

93.398, Cancer Research Manpower; 93.399, 

Cancer Control, National Institutes of Health, 

HHS) 


ycherry on PROD1PC64 with NOTICES
Federal Register / Vol. 72, No. 19 / Tuesday, January 30, 2007 / Notices 4277 

Dated: January 21, 2007. 

David Clary, 

Acting Director, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 07–365 Filed 1–29–07; 8:45 am] 

BILLING CODE 4140–01–M 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Institute of General Medical 

Sciences; Notice of Closed Meeting 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. Appendix 2), notice 

is hereby given of the following 

meeting. 

The meeting will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: Minority Programs 

Review Committee, MARC Review 

Subcommittee A. 

Date: February 15, 2007. 

Time: 8 a.m. to 5 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: Hyatt Regency Bethesda, One 

Bethesda Metro Center, 7400 Wisconsin Ave., 

Bethesda, MD 20814. 

Contact Person: Mona R. Trempe, PhD, 

Scientific Review Administrator, Office of 

Scientific Review, National Institute of 

General Medical Sciences, National Institutes 

of Health, 45 Center Drive, Room 3AN12, 

Bethesda, MD 20892, 301–594–3998, 

trempemo@mail.nih.gov. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.375, Minority Biomedical 

Research Support; 93.821, Cell Biology and 

Biophysics Research; 93.859, Pharmacology, 

Physiology, and Biological Chemistry 

Research; 93.862, Genetics and 

Developmental Biology Research; 93.88, 

Minority Access to Research Careers; 93.96, 

Special Minority Initiatives, National 

Institutes of Health, HHS) 

Dated: January 21, 2007. 

David Clary, 

Acting Director, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 07–358 Filed 1–29–07; 8:45 am] 

BILLING CODE 4140–01–M 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Institute of Nursing Research; 

Notice of Closed Meeting 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. Appendix 2), notice 

is hereby given of the following 

meeting. 

The meeting will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: National Institute of 

Nursing Research Special Emphasis Panel, 

Mentored Research Scientist Development 

Award. 

Date: March 5, 2007. 

Time: 7:30 a.m. to 8 a.m. 

Agenda: To review and evaluate grant 

applications. 

Place: Crowne Plaza Hotel, 8777 Georgia 

Avenue, Silver Spring, MD 20910. 

Contact Person: John E. Richters, PhD, 

Chief, Office of Review, Division of 

Extramural Activities, National Institute of 

Nursing Research, National Institutes of 

Health, 6701 Democracy Blvd. Room 715, 

Bethesda, MD 20817, (301) 594–5971, 

jrichters@nih.gov. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.361, Nursing Research, 

National Institutes of Health, HHS) 

Dated: January 21, 2007. 

David Clary, 

Acting Director, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 07–359 Filed 1–29–07; 8:45 am] 

BILLING CODE 4140–01–M 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Institute of of Nursing 

Research; Notice of Closed Meeting 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. Appendix 2), notice 

is hereby given of the following 

meeting. 

The meeting will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: National Institute of 

Nursing Research Special Emphasis Panel, 

RFA–NR–07–002/3: Culturally Appropriate 

Research to Prevent HIV Transmission. 

Date: March 14–15, 2007. 

Time: 8 a.m. to 3 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: Crowne Plaza Hotel, 8777 Georgia 

Avenue, Silver Spring, MD 20910. 

Contact Person: John E. Richters, PhD, 

Chief, Office of Review, Division of 

Extramural Activities, National Institute of 

Nursing Research, National Institutes of 

Health, 6701 Democracy Blvd. Room 715, 

Bethesda, MD 20817, (301) 594–5971, 

jrichters@nih.gov. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.361, Nursing Research, 

National Institutes of Health, HHS) 

Dated: January 21, 2007. 

David Clary, 

Acting Director, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 07–360 Filed 1–29–07; 8:45 am] 

BILLING CODE 4140–01–M 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Institute on Deafness and 

Other Communication Disorders; 

Notice of Closed Meeting 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. Appendix 2), notice 

is hereby given of the following 

meeting. 

The meeting will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: Communication 

Disorders Review Committee, CDRC. 

Date: February 15–16, 2007. 

Time: February 15, 2007, 8 a.m. to 5 p.m. 

Agenda: To review and evaluate grant 

applications. 


ycherry on PROD1PC64 with NOTICES