**Exhibit 10.21**

**ROYALTY TERMINATION AGREEMENT**

**THIS ROYALTYTERMINATION AGREEMENT** (this “Agreement”) is made as of November 17, 2010, by and among AUTOVAXID, INC., a Florida corporation (“AutovaxID”) and BIOVEST INTERNATIONAL, INC., a Delaware corporation(“Biovest”), on the one hand, and LV ADMINISTRATIVE SERVICES, INC., a Delaware corporation, as administrative and collateral agent for the Lenders (the “Agent”), LAURUS MASTER FUND, LTD. (IN LIQUIDATION)(“Laurus”), VALENS U.S. SPV I, LLC, VALENS OFFSHORE SPV I, LTD., VALENS OFFSHORE SPV II, CORP. and PSOURCE STRUCTURED DEBT LIMITED (collectively, the “Prepetition Lenders” and together with the Agent, the“Creditor Parties”), on the other hand. 

**RECITALS**

**WHEREAS**, pursuant to that certain letter agreement dated as of March 19, 2007 (the “March 2007Agreement”), by and among Biovest, the Biovest Subsidiaries, Accentia and Laurus, Biovest and AutovaxID granted to Laurus a non-cancelable royalty equal to three percent (3%) of world-wide Net Sales (defined as gross receipts from theworld-wide sales of AutovaxIDTM Instruments less any rebates, returns and discounts) of AutovaxIDTM Instruments (defined as the automated cell and biologic production instrument known as AutovaxIDTM) for a period of five years commencingon May 31, 2007 (the “AutovaxID Royalty”); 

**WHEREAS**, pursuant to that certainTerm Loan and Security Agreement (the “Security Agreement”) dated as of November 17, 2010, by and among Biovest, the Lenders party thereto and the Agent, the parties hereto, in consideration for the acceptance by certain of thePrepetition Lenders of the allowed secured claims against Biovest as provided therein, have agreed, among other things, to the termination of the AutovaxID Royalty; and 

**WHEREAS**, pursuant to the terms and conditions of the Security Agreement and the Confirmed Plan, the parties heretohereby desire to terminate the AutovaxID Royalty effective as of the date of this Agreement. 

**NOW,THEREFORE**, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto hereby agree as follows: 

1.        Capitalized terms used but not defined herein shall have the meanings ascribed to them in the Security Agreement. 

2.        The parties hereto agree that the above Recitals are true and correctin all respects. 

3.        The parties hereto hereby consent to thetermination of the AutovaxID Royalty (and all of the rights and obligations created thereunder) effective as of the date of this Agreement. 

4.        Each of the Creditor Parties hereby acknowledges and agrees that it shall have no claims of any nature whatsoever against Biovest, AutovaxID or Accentiaas a result of the termination of the AutovaxID Royalty. 

 
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5.        This Agreement shall bebinding upon the parties hereto and their respective successors and assigns. The parties hereto agree that this Agreement is fully and adequately supported by consideration, is fair and reasonable, and that they have had the opportunity to discussthis matter with counsel of their choice. This Agreement may be executed in one or more counterparts, each of which shall be deemed an original and all of which together shall be deemed to constitute one agreement. It is understood and agreed thatif facsimile copies of this Agreement bearing facsimile signatures are exchanged between the parties hereto, such copies shall in all respects have the same weight, force and legal effect and shall be fully as valid, binding, and enforceable as ifsuch signed facsimile copies were original documents bearing original signature. 

6.        THIS AGREEMENT SHALL BE GOVERNED BY, AND CONSTRUED, INTERPRETED ANDENFORCED ACCORDING TO, THE LAWS OF THE STATE OF NEW YORK, WITHOUT REGARD TO PRINCIPLES OF CONFLICT OF LAWS PROVISIONS THEREOF. ANY ACTION BROUGHT CONCERNING THE TRANSACTIONS CONTEMPLATED BY THIS AGREEMENT SHALL BE BROUGHT ONLY IN THE STATECOURTS OF NEW YORK OR IN THE FEDERAL COURTS LOCATED IN THE STATE OF NEW YORK. The prevailing party shall be entitled to recover from the other party its reasonable attorneys’ fees and costs. Wherever possible each provision of thisAgreement shall be interpreted in such manner as to be effective and valid under applicable law, but if any provision of this Agreement shall be prohibited by or invalid under such law, such provision shall be ineffective to the extent of suchprohibition or invalidity, without invalidating the remainder of such provision or the remaining provisions of this Agreement. 

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**IN WITNESS WHEREOF**, the undersigned have executed this Agreement as of the date firstabove written. 

 
AUTOVAXID, INC.By: 
/s/ David Moser
Name: David MoserTitle: Secretary
 
BIOVEST INTERNATIONAL, INC.By: 
/s/ David Moser
Name: David MoserTitle: Secretary
 
LV ADMINISTRATIVE SERVICES, INC.By: 
/s/ PatrickRegan
Name: Patrick ReganTitle: Authorized Signatory
 

LAURUS MASTER FUND, LTD. (IN

LIQUIDATION)
By: 
/s/ RussellSmith
Name: Russell SmithTitle: Joint Official Liquidator (with no personalliability)
 
VALENS U.S. SPV I, LLCBy: 
/s/ PatrickRegan
Name: Patrick ReganTitle: Authorized Signatory
 

VALENS OFFSHORE SPV I,LTD.
By: 
/s/ PatrickRegan
Name: Patrick ReganTitle: Authorized Signatory
 
VALENS OFFSHORE SPV II, CORP.By: 
/s/ PatrickRegan
Name: Patrick ReganTitle: Authorized Signatory
 
PSOURCE STRUCTURED DEBT LIMITEDBy: PSource Capital Ltd, It’s Investment ConsultantBy: 
/s/ CharlesLews
Name: Charles LewsTitle: Associate Director