Summay of the Effect of Atrazine on the Proestrous LH Surge: Comple

Summary (by dose and kill time) of animals in the study of evaluating the effect of atrazine on the proestrous LH surge. The vafemale was examined for approximately two week prior to selection for study and only those female revealing regular 4-day vagDosing by oral gavage commenced on vaginal estrus and continued daily until the day of proestrus during which the rats were designated below. Females included in the analysis were selected on the basis of uterine wt at the time of kill (greater than 0.5 the later time points elevated progesterone values. 

1
Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 

Control 1200 32692 275 0.554 201.45 13.2 Pro 

Control 1200 32275 361 0.677 187.45 12.6 Pro 

Control 1200 32203 312 0.686 219.78 14.1 Pro 

Control 1200 32781 314 0.861 274.08 12.8 P 

Control 1200 32821 315 0.671 213.14 8.9 P 

Control 1200 32220 271 0.596 219.82 10.4 P 

Control 1200 32163 331 0.750 226.62 15.3 Pro 

Control 1200 33451 297 0.718 241.78 13.4 P 

Control 1200 33456 270.5 0.747 276.27 12.9 P 

Control 1200 33511 267 0.528 197.90 12.5 P 

Control 1200 33408 284 0.629 221.51 12.4 ydp 

Control 1200 33162 288.2 0.603 209.09 14 P 

Control 1200 33018 258.5 0.965 373.31 14.9 P 

Control 1200 32189 320 0.521 162.88 12.6 ydp 

Control 1200 33645 291 0.752 258.52 13.9 PRO 

Control 1200 33655 280 0.650 232.14 11.1 PRO 

Control 1200 33662 276 0.838 303.77 13.3 PRO 

Control 1200 33712 367 0.799 217.77 12.8 PRO 

Mean 298.7888889 0.697 235.40 12.8388889 SD 31.35971355 0.120 48.40 1.5328324 N 18 18.000 18.00 18 SEM 7.391555369 0.028 11.41 0.36129206 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle Control 1400 32240 270 0.644 238.52 15.9 Pe 

Control 1400 32804 287 0.732 254.98 12.2 P 

Control 1400 32199 298 0.628 210.70 11.3 Pro 

Control 1400 33525 285 0.719 252.18 16.9 P 

Control 1400 33043 262 0.804 306.98 13.8 Pe 

Control 1400 33148 281 0.656 233.38 P 

Control 1400 33084 257.9 0.922 357.66 14.1 P 

Control 1400 33020 274.1 0.875 319.26 12.3 P 

Control 1400 33050 265.5 0.913 343.99 15.2 P 

Control 1400 33427 254.4 0.769 302.20 13.3 P Control 1400 33497 291 0.682 234.19 13.6 P Control 1400 33683 310 0.837 269.97 12.6 PRO 

Control 1400 33685 242 0.711 293.76 11.8 PRO 

Mean 275.2230769 0.761 278.29 13.5833333 SD 19.10537245 0.102 45.95 1.71349368 N 13 13.000 13.00 12 SEM 5.298876923 0.028 12.74 0.49464302 

2
3
Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 

Control 1600 32852 299 0.889 297.39 12.5 P Control 1600 32806 293 0.918 313.38 13.1 Pe 

Control 1600 32233 318 0.780 245.41 15.6 P Control 1600 32812 306 0.654 213.59 16.2 stp Control 1600 32179 281 1.039 369.68 13.2 P Control 1600 32885 311 0.556 178.81 14 P Control 1600 32219 303 0.710 234.22 13.5 Pro Control 1600 33039 327.1 0.621 189.94 15.5 P Control 1600 33110 290.7 0.862 296.66 11.3 P Control 1600 33122 279.4 0.818 292.84 15.1 P Control 1600 33704 281 0.783 278.72 9.8 PRO 

Control 1600 33719 268 0.633 236.08 12.7 PRO Control 1600 33732 277 0.772 278.66 14.9 PRO 

Control 1600 33768 253 0.447 176.60 11.4 PRO 

Mean 291.9428571 0.749 257.29 13.4857143 SD 20.30614588 0.157 56.40 1.86665358 N 14 14.000 14.00 14 SEM 5.427045766 0.042 15.07 0.49888416 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle Control 1800 32188 288 1.029 357.33 14.4 P Control 1800 32243 280 0.604 215.71 12.8 Pro Control 1800 32787 273 0.917 335.97 11 P Control 1800 32259 341 0.985 288.74 15.7 Pro Control 1800 32854 287 0.712 247.98 13.2 P Control 1800 32868 303 0.767 253.10 14.7 P Control 1800 32636 312 1.062 340.51 19.2 Pro Control 1800 32256 296 0.637 215.10 14.3 stp Control 1800 33515 260 0.980 376.88 13.2 P Control 1800 33057 296.4 0.924 311.71 16.9 P Control 1800 33102 288.5 0.806 279.27 18.4 P Control 1800 33414 318 0.743 233.71 15.6 P Control 1800 33140 297.1 0.874 294.11 16.1 P Control 1800 33158 280.2 0.806 287.76 11.5 Pe Control 1800 33420 289 1.003 347.16 18.9 P Control 1800 33476 286 1.059 370.38 14.4 P 

Mean 293.45 0.869 297.21 15.01875 SD 18.95999297 0.149 53.96 2.46230752 N 16 16.000 16.00 16 SEM 4.739998242 0.037 13.49 0.61557688 

4
Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 

Control 1800 33644 303 0.661 218.15 14.8 PRO Control 1800 33681 288 0.993 344.79 13 PRO Control 1800 33765 252 0.785 311.67 9.8 PRO Control 1800 33795 244 1.115 456.84 11 PRO Control 1800 33802 212 0.557 262.78 9.3 PRO 

Control 1800 33809 286 0.818 286.05 10.9 PRO Control 1800 33816 245 0.832 339.71 8.1 PRO Control 1800 33820 251 0.612 243.98 7.8 PRO Control 1800 33837 279 0.663 237.74 11.8 PRO Control 1800 33839 295 0.876 296.95 10.8 PRO Control 1800 33802 287 0.851 296.59 12 PRO 

Mean 267.4545455 0.797 299.57 10.8454545 SD 28.18284456 0.167 66.05 2.06995828 N 11 11.000 11.00 11 SEM 8.911 0.053 20.89 0.654 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle Control 2000 32164 356 0.851 239.02 16.8 Pro Control 2000 32162 274 0.733 267.59 12.2 P Control 2000 32835 308 1.075 348.86 12 P Control 2000 32207 270 0.770 285.15 12.4 P Control 2000 32875 294 0.555 188.84 12 P Control 2000 32205 367 0.886 241.36 13 Pro Control 2000 32708 292 0.986 337.57 14.3 Pearly Control 2000 33412 269 0.875 325.43 14 P Control 2000 33130 277.8 1.072 385.82 18.4 P Control 2000 33378 266 0.724 272.22 12.5 P Control 2000 33082 257.9 1.161 450.06 14.3 P Control 2000 33492 289 0.978 338.30 17.5 P Control 2000 33402 284 0.764 268.98 17.8 P Control 2000 33021 317.9 0.753 236.74 14.1 P Control 2000 33393 279 0.821 294.41 11.4 P Control 2000 33754 279 0.755 270.54 13.5 D Control 2000 33690 278 0.796 286.44 10.8 PRO Control 2000 33663 228 0.798 349.96 12.3 PRO 

Mean 288.1444444 0.853 299.29 13.85 SD 32.95690987 0.151 62.25 2.3119256 N 18 18.000 18.00 18 

5
SEM 7.768018153 0.036 14.67 0.54492609 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 1.5 mg/kg 1200 33654 279 0.611 218.82 15.1 PRO 

1.5 mg/kg 1200 33666 299 0.597 199.70 12 PRO 

1.5 mg/kg 1200 33670 285 0.706 247.58 11.3 PRO 

1.5 mg/kg 1200 33723 346 0.543 156.79 10.9 PRO 

1.5 mg/kg 1200 33740 378 0.885 234.23 15.5 PRO 

Mean 317.4 0.668 211.42 12.96 SD 42.87540087 0.135 35.37 2.17669474 N 5 5.000 5.00 5 SEM 19.17446218 0.060 15.82 0.97344748 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 1.5 mg/kg 1400 33651 280 0.619 221.04 12.9 PRO 

1.5 mg/kg 1400 33684 274 0.663 241.79 13.8 PRO 

Mean 277 0.641 231.41 13.35 SD 4.242640687 0.031 14.67 0.6363961 N 2 2.000 2.00 2 SEM 3 0.022 10.38 0.45 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 1.5 mg/kg 1600 33706 280 0.803 286.79 8.6 PRO 

1.5 mg/kg 1600 33708 278 0.557 200.32 13.1 PRO 

Mean 279 0.680 243.55 10.85 SD 1.414213562 0.174 61.14 3.18198052 N 2 2.000 2.00 2 SEM 1 0.123 43.23 2.25 

6
Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 

1.5 mg/kg 1800 33763 270 0.491 181.89 10.6 PRO 1.5 mg/kg 1800 33647 275 0.642 233.45 11.3 PRO 1.5 mg/kg 1800 33682 301 0.719 238.97 11.9 PRO 1.5 mg/kg 1800 33781 266 0.722 271.58 11.7 PRO 1.5 mg/kg 1800 33803 268 0.747 278.81 9.7 PRO 1.5 mg/kg 1800 33748 288 0.795 275.90 14.8 PRO 1.5 mg/kg 1800 33841 245 0.807 329.51 10.6 PRO 1.5 mg/kg 1800 33829 254 0.821 323.31 12.6 PRO 1.5 mg/kg 1800 33832 255 0.856 335.53 11.1 PRO 1.5 mg/kg 1800 33819 255 0.943 369.84 9.2 PRO 1.5 mg/kg 1800 33821 243 1.011 415.88 10.2 PRO 

Mean 265.4545455 0.778 295.88 11.2454545 SD 17.78405823 0.141 66.89 1.53711654 N 11 11.000 11.00 11 SEM 5.36209531 0.042 20.17 0.46345808 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 1.5 mg/kg 2000 33779 288 0.437 151.60 13.3 PRO 

1.5 mg/kg 2000 33729 277 0.849 306.61 14.3 PRO 1.5 mg/kg 2000 33700 255 0.861 337.61 10.6 PRO 1.5 mg/kg 2000 33760 250 0.975 389.92 12.1 PRO 1.5 mg/kg 2000 33667 259 0.985 380.19 13.6 PRO 

Mean 265.8 0.821 313.18 12.78 SD 16.0530371 0.224 96.34 1.45499141 N 5 5.000 5.00 5 SEM 7.179136438 0.100 43.09 0.65069194 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 3.12 mg/kg 1200 33659 263 0.814 309.47 11.6 PRO 

3.12 mg/kg 1200 33671 252 0.716 283.97 13.2 PRO 

3.12 mg/kg 1200 33697 322 0.645 200.34 12.9 PRO 

3.12 mg/kg 1200 33727 358 0.776 216.68 10.1 PRO 

3.12 mg/kg 1200 33680 276 0.730 264.38 14.4 PRO 

Mean 294.2 0.736 254.97 12.44 

7
SD 44.52190472 0.064 45.69 1.64408029 

N 5 5.000 5.00 5 SEM 19.9 0.028 20.87 0.730.643 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 3.12 mg/kg 1400 33657 293 0.550 187.82 10.4 PRO 

3.12 mg/kg 1400 33711 267 0.678 253.97 13.3 PRO 

3.12 mg/kg 1400 33716 267 0.687 257.45 9.1 PRO 

3.12 mg/kg 1400 33771 274 0.695 253.50 12.2 PRO 

Mean 275.25 0.653 238.19 11.25 SD 12.28481447 0.069 33.63 1.86636902 N 4 4.000 4.00 4 SEM 6.142407237 0.034 16.81 0.93318451 

Treatment Time Animal ID Body Wt.(g) Uterus Wt (g) pit wt (mg) Cycle 3.12 mg/kg 1600 33678 287 0.696 242.54 15.8 PRO 

3.12 mg/kg 1600 33721 264 0.671 254.09 13.5 PRO 

3.12 mg/kg 1600 33726 287 0.810 282.09 13.3 PRO 

3.12 mg/kg 1600 33742 216 0.536 247.96 11.9 PRO 

Mean 263.5 0.678 256.67 13.625 SD 33.47138081 0.113 17.59 1.61529151 N 4 4.000 4.00 4 SEM 16.73569041 0.056 8.80 0.80764576 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 3.12 mg/kg 1800 33794 227 0.648 285.33 11.7 PRO 3.12 mg/kg 1800 33806 251 0.666 265.18 9.1 PRO 3.12 mg/kg 1800 33825 237 0.687 290.04 11.1 PRO 

3.12 mg/kg 1800 33738 264 0.721 272.92 12.9 PRO 

3.12 mg/kg 1800 33785 302 0.786 260.23 10.2 PRO 3.12 mg/kg 1800 33743 235 0.788 335.49 10 PRO 3.12 mg/kg 1800 33823 233 0.797 342.23 9.2 PRO 3.12 mg/kg 1800 33737 269 0.808 300.33 10.2 PRO 3.12 mg/kg 1800 33807 237 0.842 355.36 10.6 PRO 3.12 mg/kg 1800 33834 267 0.871 326.10 5.7 PRO 3.12 mg/kg 1800 33818 256 0.914 357.07 10.7 PRO 3.12 mg/kg 1800 33822 259 0.957 369.34 12.3 PRO 

Mean 253.0833333 0.790 313.30 10.3083333 

8
SD 21.180859 0.097 38.82 1.84709026 

N 12 12.000 12.00 12 SEM 6.114387322 0.028 11.21 0.53320903 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 3.12 mg/kg 2000 33733 280 0.510 182.18 14.1 PRO 

3.12 mg/kg 2000 33791 281 0.689 245.20 12.8 PRO 

3.12 mg/kg 2000 33703 292 0.748 256.27 13.7 PRO 

3.12 mg/kg 2000 33669 267 0.890 333.45 13.7 PRO 

3.12 mg/kg 2000 33761 268 0.963 359.25 12.8 PRO 

Mean 232.3523979 0.638 275.27 13.42 SD 10.35857133 0.177 71.36 0.58906706 N 5 5.000 5.00 5 SEM 4.632493929 0.079 31.91 0.2634388 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 6.25 mg/kg 1200 33075 287.5 0.665 231.30 11.9 pe 

6.25 mg/kg 1200 33164 288.5 0.860 298.20 14.2 P 

6.25 mg/kg 1200 33472 292 0.857 293.36 13.5 P 

6.25 mg/kg 1200 33134 282.7 0.787 278.46 10.9 P 

6.25 mg/kg 1200 33458 267.3 0.532 198.95 13.6 P 

6.25 mg/kg 1200 33672 293 0.615 209.73 15.4 PRO 

6.25 mg/kg 1200 33707 304 0.734 241.28 14.3 PRO 

6.25 mg/kg 1200 33728 363 0.712 196.25 9.2 PRO 

Mean 297.25 0.720 243.44 12.875 SD 28.52212174 0.115 41.77 2.05060967 N 8 8.000 8.00 8 SEM 10.08409285 0.041 14.77 0.725 

9
Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 

6.25 mg/kg 1400 33416 304.9 0.506 165.82 15.7 P 

6.25 mg/kg 1400 33503 267 0.784 293.52 15.6 P 6.25 mg/kg 1400 33418 277 0.626 226.06 15.4 P 

6.25 mg/kg 1400 33044 252.8 0.693 274.13 12.3 P 

6.25 mg/kg 1400 33438 257 1.073 417.67 12.7 P 6.25 mg/kg 1400 33461 243 0.877 360.78 13.2 P 

6.25 mg/kg 1400 33023 276.6 0.822 297.18 14.1 P 

6.25 mg/kg 1400 33092 270.9 0.969 357.81 11.4 P 

6.25 mg/kg 1400 33056 303.5 0.618 203.46 12.8 P 

6.25 mg/kg 1400 33665 268 0.662 246.83 13.4 PRO 

6.25 mg/kg 1400 33744 289 0.646 223.56 13.5 PRO 

6.25 mg/kg 1400 33780 286 0.784 274.16 15.5 PRO 

Mean 274.6416667 0.755 278.42 13.8 SD 19.06669912 0.162 72.70 1.45289679 N 12 12.000 12.00 12 SEM 5.504081933 0.047 20.99 0.41941518 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 6.25 mg/kg 1600 33117 251.6 0.634 251.83 12.9 P 6.25 mg/kg 1600 33437 280 0.834 297.89 15.2 P 6.25 mg/kg 1600 33040 267.6 0.907 338.94 15.2 P 

6.25 mg/kg 1600 33064 281.7 0.541 191.98 12.2 P 

6.25 mg/kg 1600 33123 275 0.813 295.45 14.7 P 6.25 mg/kg 1600 33756 252 0.711 282.10 12.3 PRO 

Mean 267.9833333 0.740 276.37 13.75 SD 13.459631 0.137 50.00 1.43770651 N 6 6.000 6.00 6 SEM 5.494871346 0.056 20.41 0.58694122 

10
Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 

6.25 mg/kg 1800 33104 302.3 1.068 353.42 14.2 P 6.25 mg/kg 1800 33143 272.7 0.936 343.20 16.8 P 6.25 mg/kg 1800 33059 312 0.782 250.58 14.8 P 6.25 mg/kg 1800 33439 296 1.027 346.82 10.4 P 6.25 mg/kg 1800 33103 272.8 0.551 201.83 11.6 ydp 6.25 mg/kg 1800 33465 267 0.670 251.05 14 P 

6.25 mg/kg 1800 33679 266 0.571 214.81 11.5 PRO 6.25 mg/kg 1800 33745 284 0.692 243.70 11.6 PRO 6.25 mg/kg 1800 33798 248 0.794 320.20 12.8 PRO 6.25 mg/kg 1800 33808 236 0.808 342.16 10.4 PRO 6.25 mg/kg 1800 33787 306 0.885 289.28 11.9 PRO 6.25 mg/kg 1800 33801 260 0.933 359.00 12.4 PRO 6.25 mg/kg 1800 33786 309 0.951 307.61 16.1 PRO 6.25 mg/kg 1800 33828 251 0.975 388.45 11.8 PRO 6.25 mg/kg 1800 33831 246 1.001 406.79 11.5 PRO 6.25 mg/kg 1800 33824 248 1.029 414.80 11.5 PRO 6.25 mg/kg 1800 33805 231 1.050 454.55 9.4 PRO 

Mean 271.0470588 0.866 322.84 12.5117647 SD 26.45725604 0.167 72.92 2.02912615 N 17 17.000 17.00 17 SEM 6.41682713 0.040 17.69 0.49213538 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 6.25 mg/kg 2000 33094 260.6 0.707 271.26 11.3 Pe 6.25 mg/kg 2000 33428 281 1.036 368.51 16.2 P 6.25 mg/kg 2000 33389 285 1.033 362.28 13.4 P 6.25 mg/kg 2000 33032 265 0.924 348.57 17.6 Pe 6.25 mg/kg 2000 33493 287 0.700 244.04 13.3 P 6.25 mg/kg 2000 33136 290.2 0.888 305.89 16.8 P 11 
6.25 mg/kg 2000 33403 277 0.890 321.23 12.7 P 

6.25 mg/kg 2000 33443 334 1.086 325.00 16.2 P 

Mean 284.975 0.908 318.35 14.6875 SD 22.38428977 0.145 43.60 2.28438019 N 8 8.000 8.00 8 SEM 7.914041545 0.051 15.41 0.80765036 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 12.5 mg/kg 1200 33033 255.7 0.431 168.36 10.8 ydp 12.5 mg/kg 1200 33491 308 0.668 216.82 14.8 P 

12.5 mg/kg 1200 33135 282.1 0.710 251.75 10.4 Pe 

12.5 mg/kg 1200 33423 287 0.483 168.33 13.9 P 12.5 mg/kg 1200 33459 294.2 0.633 215.13 13.7 ydp 

12.5 mg/kg 1200 33386 259.5 0.670 258.27 12.9 P 

12.5 mg/kg 1200 33035 271.2 0.758 279.31 10.4 P 

12.5 mg/kg 1200 33095 298.7 0.778 260.43 14.5 P 

12.5 mg/kg 1200 33069 303 0.706 233.10 14.5 P 

Mean 284.3777778 0.648 227.94 12.8777778 SD 18.8196558 0.118 39.69 1.8464681 N 11 11.000 11.00 11 

SEM 5.674339725 0.036 11.97 0.55673108 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 12.5 mg/kg 1400 33454 300 0.766 255.23 16.4 P 

12.5 mg/kg 1400 33478 284 0.852 299.89 11 P 

12.5 mg/kg 1400 33446 244.1 0.704 288.45 16.7 P 

12.5 mg/kg 1400 33048 294.1 0.921 313.23 15.4 P 

12.5 mg/kg 1400 33127 284.1 0.799 281.24 12.6 P 

12.5 mg/kg 1400 33419 271.7 0.561 206.55 12 P 

Mean 279.6666667 0.767 274.10 14.0166667 SD 19.94318597 0.125 38.40 2.44819662 N 6 6.000 6.00 6 SEM 8.141771579 0.051 15.68 0.99947208 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 12.5 mg/kg 1600 33384 283 0.772 272.79 14.5 P 12.5 mg/kg 1600 33105 250.8 0.641 255.54 14.8 P 12 
12.5 mg/kg 1600 33142 279.2 0.773 277.01 13.2 P 

12.5 mg/kg 1600 33073 262.1 0.539 205.65 12.1 P 12.5 mg/kg 1600 33455 278 0.704 253.06 P 12.5 mg/kg 1600 33060 268.6 0.766 285.33 13.6 P 

Mean 270.2833333 0.699 258.23 13.64 

SD 12.24882307 0.094 28.63 1.07842478 N 6 6.000 6.00 5 SEM 5.00056108 0.038 11.69 0.48228622 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 

12.5 mg/kg 1800 33484 266 0.908 341.50 13 P 

12.5 mg/kg 1800 33156 283.4 0.690 243.51 13.3 P 

12.5 mg/kg 1800 33024 301.6 0.973 322.61 14.2 P 

12.5 mg/kg 1800 33485 263 0.967 367.68 15.6 P 

12.5 mg/kg 1800 33107 275.6 0.724 262.55 13.7 P 

12.5 mg/kg 1800 33078 282.8 0.659 232.96 13.4 P 

12.5 mg/kg 1800 33502 289 0.896 310.07 17.9 P 

Mean 280.2 0.831 297.27 14.4428571 SD 13.36063871 0.135 51.56 1.75010204 N 7 7.000 7.00 7 SEM 5.049846768 0.051 19.49 0.66147639 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 12.5 mg/kg 2000 33445 278 1.141 410.58 13.9 P 12.5 mg/kg 2000 33494 289 0.944 326.68 14 P 12.5 mg/kg 2000 33144 307.9 0.898 291.69 15.8 P 12.5 mg/kg 2000 33398 249 0.717 288.11 14.4 P 12.5 mg/kg 2000 33405 267 1.105 413.86 16.3 stp 12.5 mg/kg 2000 33097 302.2 0.906 299.93 15 P 12.5 mg/kg 2000 33463 284 0.752 264.65 11.8 P 12.5 mg/kg 2000 33154 283.5 0.974 343.67 13.9 P 12.5 mg/kg 2000 33071 239.1 0.853 356.80 12.1 ydP 

Mean 277.7444444 0.921 332.88 14.1333333 SD 22.75280813 0.142 53.34 1.5 N 9 9.000 9.00 9 SEM 7.584269376 0.047 17.78 0.5 

13
Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 

25 mg/kg 1200 33116 267.6 0.504 188.30 14.3 P 

25 mg/kg 1200 33464 265.7 0.548 206.10 12.6 P 

25 mg/kg 1200 33041 279.4 0.725 259.41 13.4 P 

25 mg/kg 1200 33038 318.8 1.073 336.67 13 P 

25 mg/kg 1200 33072 257.1 0.640 249.05 13.4 P 

25 mg/kg 1200 33457 255 0.575 225.33 10.7 P 

25 mg/kg 1200 33394 274.8 0.568 206.51 14.2 P 

25 mg/kg 1200 33146 264.6 0.527 199.09 11.4 Pe 

Mean 272.875 0.645 233.81 12.875 SD 20.25387088 0.187 48.30 1.27251158 N 8 8.000 8.00 8 SEM 7.160824723 0.066 17.08 0.44990078 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 25 mg/kg 1400 32815 282 0.779 276.24 13.7 P 

25 mg/kg 1400 32725 283 0.631 222.86 16.3 Pearly 

25 mg/kg 1400 32260 258 0.553 214.34 11.9 ydP 

25 mg/kg 1400 32245 287 1.038 361.50 15.4 Pe 

25 mg/kg 1400 32857 276 0.860 311.70 16.1 P 

25 mg/kg 1400 32201 295 0.601 203.69 14.6 Pro 

25 mg/kg 1400 33166 299.5 0.629 210.02 13.6 P 

25 mg/kg 1400 33487 305.3 0.510 167.02 7.8 ydp 

25 mg/kg 1400 33053 299.2 0.877 292.98 13.5 P 

25 mg/kg 1400 33425 273.2 0.779 285.21 10 P 

25 mg/kg 1400 33132 293.7 0.705 240.07 14.3 P 14 
25 mg/kg 1400 33467 296 0.860 290.68 12.3 P 

25 mg/kg 1400 33062 299.8 0.755 251.70 11.4 P 

25 mg/kg 1600 33470 283 0.920 324.91 13.9 P 

Mean 287.9071429 0.750 260.92 13.2 SD 12.98410059 0.153 54.31 2.35600705 N 14 14.000 14.00 14 SEM 3.470146849 0.041 14.52 0.62966937 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 25 mg/kg 1600 32617 279 0.827 296.45 11.3 Pro 

25 mg/kg 1600 32832 318 1.191 374.37 16.9 P 25 mg/kg 1600 32643 273 0.812 297.47 14 Pro 25 mg/kg 1600 32855 301 0.755 250.73 14.6 P 

25 mg/kg 1600 32871 301 0.780 258.97 P 

25 mg/kg 1600 32235 295 0.842 285.32 13.9 P 

25 mg/kg 1600 33083 303.9 0.875 287.86 16.4 P 25 mg/kg 1600 33155 257.5 0.815 316.35 14.2 P 25 mg/kg 1600 33153 295.3 0.824 279.00 13.8 P 25 mg/kg 1600 33120 292.1 1.079 369.39 14.7 P 25 mg/kg 1600 33407 274 0.722 263.54 15.9 P 

Mean 289.9818182 0.865 298.13 14.57 SD 17.31749509 0.142 41.03 1.59028299 N 11 11.000 11.00 10 SEM 5.221421231 0.043 12.37 0.50289164 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 25 mg/kg 1800 32789 323 1.038 321.27 16 P 25 mg/kg 1800 32872 282 0.803 284.68 14 P 25 mg/kg 1800 32876 288 0.899 312.05 13.9 P 25 mg/kg 1800 32195 260 0.744 286.23 8.8 P 25 mg/kg 1800 32800 270 0.917 339.78 11.1 P 25 mg/kg 1800 32640 321 0.902 280.84 14.4 Pro 25 mg/kg 1800 32779 272 0.809 297.32 15.3 P 

25 mg/kg 1800 32267 294 0.710 241.39 14 ydp 15 
25 mg/kg 1800 33385 260 0.643 247.35 14.8 P 

25 mg/kg 1800 33125 236.5 0.868 366.89 13.1 Pe 25 mg/kg 1800 33505 301 0.951 315.85 16.2 P 

25 mg/kg 1800 33141 259.9 0.513 197.38 16.9 RE 25 mg/kg 1800 33046 290.3 0.797 274.47 14.8 P 25 mg/kg 1800 33159 309.7 0.891 287.57 15.7 yd 

Mean 283.3857143 0.820 289.51 14.2142857 SD 25.3027167 0.135 42.70 2.12850874 N 14 14.000 14.00 14 SEM 6.76243549 0.036 11.41 0.56886789 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 25 mg/kg 2000 32171 312 0.978 313.53 15.3 Pe 25 mg/kg 2000 32718 291 0.912 313.40 15.6 P 25 mg/kg 2000 32170 292 0.687 235.34 12.9 ydp 25 mg/kg 2000 32878 288 0.758 263.33 11.8 P 

25 mg/kg 2000 32846 299 0.951 317.99 14 ydp 25 mg/kg 2000 32892 265 0.802 302.49 10.3 P 25 mg/kg 2000 33099 269.7 1.101 408.05 15.5 P 25 mg/kg 2000 33081 297.7 0.668 224.22 16.6 P 25 mg/kg 2000 33447 307 1.205 392.41 14.2 P 25 mg/kg 2000 33401 270 0.817 302.44 12.9 P 25 mg/kg 2000 33479 267 0.868 325.21 14.1 P 25 mg/kg 2000 33507 274 0.863 315.07 13.5 P 25 mg/kg 2000 33145 282.5 1.132 400.53 15.1 P 

Mean 285.7615385 0.903 316.46 13.9846154 SD 15.72442572 0.167 57.46 1.7252276 N 13 13.000 13.00 13 SEM 4.361171015 0.046 15.94 0.47849204 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 75 mg/kg 1200 32227 279 0.656 235.09 13.8 P 

75 mg/kg 1200 32236 321 0.838 261.15 15.5 Pro 

75 mg/kg 1200 32847 300 0.615 204.97 13.9 ydp 

75 mg/kg 1200 32895 285 0.644 225.86 10.1 P 

75 mg/kg 1200 32665 285 0.650 228.04 13.9 Pearly 16 
75 mg/kg 1200 32183 290 0.698 240.72 15.4 Pe 

75 mg/kg 1200 32839 287 1.120 390.07 10.2 P 

75 mg/kg 1200 32264 306 0.940 307.06 13.9 Pe 

Mean 294.125 0.770 261.62 13.3375 SD 13.94312427 0.181 60.14 2.08459486 N 8 8.000 8.00 8 SEM 4.92963886 0.064 21.26 0.73701558 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 75 mg/kg 1400 32178 277 0.725 261.73 13.7 P 

75 mg/kg 1400 32262 308 0.873 283.31 12.3 Pro 

75 mg/kg 1400 32231 274 0.644 235.15 12.6 pe 

75 mg/kg 1400 32869 264 0.733 277.50 7.8 P 75 mg/kg 1400 32202 288 0.600 208.37 14.1 ydP 

75 mg/kg 1400 32689 259 0.540 208.38 13.5 Pearly 

Mean 278.3333333 0.686 245.74 12.3333333 SD 17.73884626 0.118 33.41 2.32264217 N 6 6.000 6.00 6 SEM 7.241853661 0.048 13.64 0.9482147 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 75 mg/kg 1600 32644 253 0.622 245.89 15.1 Pro 75 mg/kg 1600 32633 289 0.947 327.68 15.3 Pro 75 mg/kg 1600 32224 265 0.651 245.47 12.1 STP 75 mg/kg 1600 32856 278 0.682 245.32 13.4 P 75 mg/kg 1600 32187 285 0.715 250.98 14.2 stp 75 mg/kg 1600 32898 269 0.807 299.93 PRO 75 mg/kg 1600 36853 0.595 14.2 PRO 

75 mg/kg 1600 37213 0.857 12.8 PRO 75 mg/kg 1600 37232 0.918 11.7 PRO 75 mg/kg 1600 37619 0.690 10.71 PRO 

75 mg/kg 1600 37626 1.022 13.74 PRO 17 
75 mg/kg 1600 37664 0.796 10.74 PRO 

75 mg/kg 1600 37724 0.785 12.64 PRO 75 mg/kg 1600 37731 0.699 11.62 PRO 

75 mg/kg 1600 37979 0.815 12.34 PRO 

Mean 273.1666667 0.773 269.21 12.8992857 SD 13.45238517 0.125 35.70 1.48082339 N 6 15.000 6.00 14 SEM 5.491913247 0.032 14.57 0.3957667 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 75 mg/kg 1800 32206 253 0.674 266.48 10.3 P 75 mg/kg 1800 32795 289 1.031 356.68 14.7 P 75 mg/kg 1800 32661 268 0.757 282.50 14.4 Pro 75 mg/kg 1800 32251 245 0.836 341.14 11.3 PE 75 mg/kg 1800 32272 325 0.703 216.18 12.8 Pro 75 mg/kg 1800 32881 287 1.080 376.13 13.9 P 75 mg/kg 1800 32882 309 0.917 296.89 14.2 P 75 mg/kg 1800 32674 292 0.699 239.52 13.2 PE 75 mg/kg 1800 36886 0.893 16 stp 75 mg/kg 1800 37321 0.657 11.1 PRO 

75 mg/kg 1800 37973 0.985 15.39 PRO 75 mg/kg 1800 38077 0.602 11.29 Pe 

75 mg/kg 1800 37974 0.811 13.13 PRO 75 mg/kg 1800 38032 0.861 13.67 PRO 75 mg/kg 1800 37272 1.055 14.6 PRO 75 mg/kg 1800 37288 0.923 15.6 PRO 75 mg/kg 1800 36915 1.105 13.1 PRO 75 mg/kg 1800 36914 0.981 12 PRO 75 mg/kg 1800 37234 0.882 14.3 PRO 75 mg/kg 1800 37256 1.054 16.5 P 

Mean 283.5 0.875 296.94 13.574 SD 27.09770681 0.155 57.01 1.72828604 

18
N 8 20.000 8.00 20 

SEM 9.580486119 0.035 20.16 0.38645651 

Treatment Time Animal ID Body Wt.(g) Uterus (g) Ut Wt /100 g BW pit wt (mg) Cycle 75 mg/kg 2000 32796 314 0.793 252.64 14 P 

75 mg/kg 2000 32173 275 0.852 309.64 14.9 P 

75 mg/kg 2000 32866 285 0.928 325.75 14.8 yd 

75 mg/kg 2000 32214 268 0.762 284.48 14.9 Pe 

75 mg/kg 2000 32784 321 0.784 244.36 14.9 P 

75 mg/kg 2000 32889 273 0.923 338.24 12.8 ydp 

75 mg/kg 2000 32712 261 0.764 292.72 12.2 PE 75 mg/kg 2000 37309 0.732 15.5 PRO 

75 mg/kg 2000 36868 0.851 11.7 PRO 

75 mg/kg 2000 37282 0.789 14.1 PRO 75 mg/kg 2000 37273 0.761 10.4 PRO 

75 mg/kg 2000 37316 0.794 12.7 PRO 

75 mg/kg 2000 37958 0.807 12.89 PRO 

75 mg/kg 2000 38008 0.760 13.03 PRO 

75 mg/kg 2000 36956 0.653 12.3 PRO 75 mg/kg 2000 37637 0.821 7.62* PRO 75 mg/kg 2000 37638 0.595 10.81 PRO 

Mean 285.2857143 0.787 292.55 13.245625 SD 23.25735931 0.082 35.27 1.55099524 N 7 17.000 7.00 16 SEM 8.790455554 0.020 13.33 0.38774881 

19
20
21
22
23
24
25
26