# Support Documents for Significant New Use Rules (SNUR) on Premanufacture Notices (PMN) P-12-275

EPA Docket EPA-HQ-OPPT-2012-0450

# Index A-001 Structure Activity Team (SAT) Report for PMN P-12-275 A-002 Initial Review Engineering Report for PMN P-12-275 A-003 Initial Review Exposure Report for PMN P-12-275

# A-001 Structure Activity Team (SAT) Report for PMN P-12-275

## SAT Report PMN Number: P-12-0275 SAT Date: 4/10/2012 Print Date: 5/2/2012
Related cases : Health related cases: Ecotox related cases :
Concern levels : 

### Type of Concern: Health Eco Comments Level of Concern: 2 2

Persistence Bioaccum Toxicity Comments 2 32

Exposure Based Review : Health: N o Ecotox: N o Routes of exposure : Health: Dermal Drinking Water Inhalation Ecotox: All releases to water Fate: ; Keywords : Keywords: SEVER IRR/POSS CORR E,S,L,MM,GI ACUTE LIVER SENS-S AQUATOX-A,C Summary of Assessment : Fate : Fate Summary: P-12-0275 = T-12-0008 FATE: Estimations for covalent ion pair MW 435 C26H56ClP Solid with MP = 132 C (E) log Kow = 6.48 (E) S = Dispersible / 0.005 mg/L at 25 C (ICB / E) VP < 1.0E-6 torr at 25 C (E)

### BP > 400 C (E) H = 6.57E-2 (E) log Koc = 7.66 (E) log Fish BCF = 2.57 (E) log Fish BAF = 4.40 (E) POTW removal (%) = 95 via sorption Time for complete ultimate aerobic biodeg = mo Sorption to soils/sediments = v.strong Volatilization half-life from a standard river = 6 hrs Volatilization half-life from a standard lake = 8 da Atmospheric Oxidation Half-life = 4.3 hr via OH radical PBT Potential: P2B3 *CEB FATE: Migration to ground water = negl
Health : Health Summary: Absorption is nil through the skin for the neat material, but poor through the skin for the material in solution, and poor through the lung and GI tract, based on physical/chemical properties. There are concerns for severe irritation/ p ossible corrosion to all exposed tissues, acute toxicity, and adverse effects to the liver, based on analogs and summary test data in the PMN MSDS (rat acute oral LD50 611 mg/kg, rat 4hr inhalation LC50 > 0.125 < 0.5 mg/l). There also is concern for dermal sensitization based on ( p ositive in the mouse LLNA). Test Data: Submitted with the PMN: Salmonella assay negative with and without activation; E. coli reverse mutation assay negative with and without activation
Ecotox : Test Organism Test Type Test End Point Predicted Measured Comments

fish 96-h LC50 2.0 daphnid 48-h LC50 1.8 green algal 96-h EC50 1.8 fish

_ chronic value 0.11 CAR 18 daphnid

_ chronic value 0.13 CAR 14 algal

_ chronic value 0.45 CAR 4 Sewage Sludge 3-h EC50

_ Sewage Sludge

_ Chronic Value _

Ecotox Values Comments: Predictions are based on SAR-nearest analog method for cationic

### surfactants-monoalkyl with 14 carbons in the largest hydrophobe;; SAR chemical class = surfactant-cationic-monoalkyl-C14; MW 435; p H7; effective concentrations based on 100% active ingredients and nominal concentrations; hardness <180.0 mg/L as CaCO3; and TOC <2.0 mg/L;
Factors Values Comments Assessment Factor 10 Concentration of Concern ( p pb) 11

SARs cationic surfactants SAR Class surfactant-cationic-C14 Ecotox Category Cationic (quaternary ammonium) surfactants
Ecotox Factors Comments:
SAT Chair: J. Kwiat

# A-002 Initial Review Engineering Report for PMN P-12-275

### INITIAL REVIEW ENGINEERING REPORT PMN: 12-0275 Focus Ready Draft 4/19/2012 ENGINEER: Arnold \ AG PV (kg/yr):

SUBMITTER: Cytec Industries Inc. USE: Chemical intermediate for production of a proprietary chemical for the electronics industry.

OTHER USES:

MSDS: Yes Label: No Gen Eqpt: Eye Protection: Prevent eye and skin contact. Wear eye/face protection such as chemical splash proof goggles or face shield. // Skin Protection: Prevent contamination of skin or clothing when removing protective equipment. Wear impermeable gloves and suitable protective clothing. // Engineering Measures:| Utilize a closed system process where feasible. Where this material is not used in a closed system, good enclosure and local exhaust ventilation should be provided to control exposure. Respirator: Where exposures are below the established exposure limit, no respiratory protection is required. Where exposures exceed the established exposure limit, use respiratory protection recommended for the material and level of exposure. Health Effects: Causes burns of eyes and skin. May be fatal if inhaled. TLV/PEL: None Established

CRSS :

### Consumer Use: No SAT (concerns) (04/10/2012): Related Cases and Related Cases and Misc SAT Info: Ecotox Related Cases: Analogs: // Human Health Related Cases: Migration to groundwater: Negligible PBT rating: P2B3T2 . Health: 2 Dermal, Drinking Water, Inhalation Eco: 2 Water (All releases to water with a CC = 11 ppb)
OCCUPATIONAL EXPOSURE RATING: 1A
NOTES & KEY ASSUMPTIONS: Generated by the 06/07/2005 version of ChemSTEER.

POLLUTION PREVENTION CONSIDERATIONS: None.

EXPOSURE-BASED REVIEW: No
INITIAL REVIEW ENGINEERING REPORT PMN: 12-0275

### Use: Production of Proprietary Chemical for Electronics Industry
Number of Sites/ Location: 1 SACHEM Inc. Cleburne TX Days/yr: 100 Basis:

Process Description: Import PMN ( PMN suspension in water; drums) --> Charge raw materials into process vessel --> Reaction (PMN reacted) --> Final Product Packaging (per submission and CRSS)
ENVIRONMENTAL RELEASES ESTIMATE SUMMARY IRER Note: The daily releases listed for any source below may coincide with daily releases from the other sources to the same medium. // Note PMN is consumed during reaction, so equipment cleaning residuals not expected. Submission estimates at most trace residuals may not be consumed. Submission states there will be no discharges to surface water from this operation.
Incineration High End: 4.5E+0 kg/site-day over 100 days/yr from 1 site or 4.5E+2 kg/yr to: Off-site Incineration from: Cleaning Liquid Residuals from Drums Used to Transport the Raw Material basis: EPA/OPPT Drum Residual Model, CEB standard residual. Submission states delivery containers will be rinsed with water after each use, and rinse water is sent to off-site incineration. presumably from drum residual, to incineration. Since customer site is identified by submitter, CEB assesses release according to submission.
RELEASE TOTAL 4.5E+2 kg/yr - all sites

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY Tot. # of workers exposed via assessed routes: 3 Basis: Submission estimates 1 worker. CEB assesses 3 workers/site as default minimum.
Inhalation: negligible (VP < 0.001 torr)

### Dermal: Exposure to Liquid at % concentration High End: 9.2E+2 mg/day over 100 days/yr Number of workers (all sites) with dermal exposure: 3 Basis: Unloading Liquid Raw Material from Drums; EPA/OPPT 2-Hand Dermal Contact with Liquids Model.

# A-003 Initial Review Exposure Report for PMN P-12-2754/18/12 Page of



### INITIAL REVIEW EXPOSURE REPORT (IRExR)
Chemical ID: P-12-0275 Reviewer: Flessner/AG

Results Table: Dose, Concentration, and Days Exceeded Results Summary

Exposure Scenario 1 Water Landfill Stack Air Fugitive Air
Drinking Water Fish Ingestion ADR LADD ADR LADD 7Q10 4 CC =

11 PDM Days Exceede d LADD ADR LADD ADR LADD

Release activity(ies) 2 ; exposure calculation(s) 3 mg/kg/day m g/kg/day mg/kg/day mg/kg/day μg/l # Days mg/kg/day m g/kg/day mg/kg/day mg/kg/day mg/kg/day

USE: Max ADR --- --- --- --- --- --- --- 5.57E-03 --- --- ---

USE: Max LADD --- --- --- --- --- --- --- --- 1 .22E-04 --- ---

1 Exposure scenario titles consist of release activity followed by exposure calculation abbreviation. 2 Release activities are from engineering report's Manuf acturing (Mfg), Processing (Proc) and Use release activity labels. Multiple release activities are combined in one exposure scenario if their releases occur at same location. 3 Exposure calculations are Acute Dose Rate (A DR), Lifetime Average Daily Dose (LADD), and Probabilistic Dilution Model (PDM). Th ere may be one, two, or all three exposure calculations per exposure scenario. CC is the aquatic concentration of concern. 4 This column displays concentration values for the 7Q 10 streamflow, which is defined as the average daily streamflow of the seven consecutive days of lowest flow within a ten year period.
Remarks:4/18/12 Page of

INITIAL REVIEW EXPOSURE REPORT

Chemical ID: P-12-0275 Assessor: Flessner/AG
ENVIRONMENTAL RELEASES
Scenario#:1 Number of Release Sites: Release Activity: USE: Max ADR Release Description: WATER LANDFILL Non-sludge/Sludge STACK FUGITIVE

Total Releases: (k g/yr) (kg/yr) (kg/yr) (kg/yr)

Non-sludge/Sludge Release Days/yr:
Per Site Release: (kg /site/day) (kg/site/day) (kg/site/day) (kg/site/day)

Remarks:4/18/12 Page of

INITIAL REVIEW EX POSURE REPORT Chemical ID: P-12-0275
INHALATION EXPOSURE ESTIMATES (POST-TREATMENT)
SCENARIO #: 1 RELEASE ACTIVITY:USE: Max ADR RELEASE DESCRIPTION: METHOD OF CALCULATION: Screen3 EXPOSED POPULATION: Adult

Number of Sites: Per Site Fugitive Release: kg/site/day Fugitive Release Days per Year: days % Removal via Fugitive Release: % Total Fugitive Release: kg/yr Max Annual Average Air Concentration (Fugitive): 0.00 μg/ m 3

Max 24 Hour Average Air Concentration(Fugitive): 0.00 μg/ m 3

Per Site Stack Release: kg/site/day Stack Release Days per Year: days % Removal via Stack Release: %
Total Stack Release: kg/yr Max Annual Average Air Con centration (Stack): 1.66 μg/m 3 Max 24 Hour Average Air Concentration (Stack): 30.30 μg/m 3

ASSUMPTIONS Exposure Units Results (Stack) Results (Fugitive) ED (years) AT (years) BW (kg) Inh. Rate (m 3 /hr) Cancer LADD pot (mg/kg/day) 1.22E-04 N/A 30.00 75.00 71.80 0.55 LADC pot (mg/m 3 ) 6.64E-04 N/ A 30.00 75.00 NA NA Acute ADR pot

(mg/kg/day) 5.57E-03 N/A NA 1 day 71.80 0.55

Inhalation Comments:4/18/12 Page of

Stack Parameter Data Fugitive Parameter Data Stack Height 10.00 m Release Height: N/A
Inside Stack Diameter: 0.10 m Length of Release Opening: N/A

Stack Gas Exit Velocity: 0.10 m /sec Width of Release Opening: N/A

Stack Gas Temperature: 293.00 K

Meteorological and Terrain Information:
Surrounding Land Use: Rural Terrain Height: 0.00 m
Distance to Residence of Interest: 100.00 m Meteorological Class: Full Stability Class: NA Wind Speed: NA

Do wnwash Information:
Facility Length: NA m Facility Width: NA m Facility Height: NA m4/18/12 Page of

INITIAL REVIEW EXPOSURE REPORT

Chemical ID: P-12-0275 Assessor: Flessner/AG
ENVIRONMENTAL RELEASES
Scenario#:2 Number of Release Sites: Release Activity: USE: Max LADD Release Description: WATER LANDFILL Non-sludge/Sludge STACK FUGITIVE

Total Releases: (k g/yr) (kg/yr) (kg/yr) (kg/yr)

Non-sludge/Sludge Release Days/yr:
Per Site Release: (kg /site/day) (kg/site/day) (kg/site/day) (kg/site/day)

Remarks:4/18/12 Page of

INITIAL REVIEW EX POSURE REPORT Chemical ID: P-12-0275
INHALATION EXPOSURE ESTIMATES (POST-TREATMENT)
SCENARIO #: 2 RELEASE ACTIVITY:USE: Max LADD RELEASE DESCRIPTION: METHOD OF CALCULATION: Screen3 EXPOSED POPULATION: Adult

Number of Sites: Per Site Fugitive Release: kg/site/day Fugitive Release Days per Year: days % Removal via Fugitive Release: % Total Fugitive Release: kg/yr Max Annual Average Air Concentration (Fugitive): 0.00 μg/ m 3

Max 24 Hour Average Air Concentration(Fugitive): N/A μg/m 3

Per Site Stack Release: kg/site/day Stack Release Days per Year: days % Removal via Stack Release: %
Total Stack Release: kg/yr Max Annual Average Air Con centration (Stack): 1.66 μg/m 3 Max 24 Hour Average Air Concentration (Stack): N/A μg/m 3

ASSUMPTIONS Exposure Units Results (Stack) Results (Fugitive) ED (years) AT (years) BW (kg) Inh. Rate (m 3 /hr) Cancer LADD pot (mg/kg/day) 1.22E-04 N/A 30.00 75.00 71.80 0.55 LADC pot (mg/m 3 ) 6.64E-04 N/ A 30.00 75.00 NA NA Acute ADR pot

(mg/kg/day) N/A N/A NA 1 day 71.80 0.55

Inhalation Comments:4/18/12 Page of

Stack Parameter Data Fugitive Parameter Data Stack Height 10.00 m Release Height: N/A
Inside Stack Diameter: 0.10 m Length of Release Opening: N/A

Stack Gas Exit Velocity: 0.10 m /sec Width of Release Opening: N/A

Stack Gas Temperature: 293.00 K

Meteorological and Terrain Information:
Surrounding Land Use: Rural Terrain Height: 0.00 m
Distance to Residence of Interest: 100.00 m Meteorological Class: Full Stability Class: NA Wind Speed: NA

Do wnwash Information:
Facility Length: NA m Facility Width: NA m Facility Height: NA m