35052 Federal Register / Vol. 72, No. 122 / Tuesday, June 26, 2007 / Notices 

The Commission has determined that 

it is not necessary to include a ‘‘cease 

and desist’’ provision that directly 

prohibits the Board from resuming the 

conduct challenged in the complaint. 

This conclusion rests on various factors 

particular to this case. A key factor is 

the experience in South Carolina since 

the 2003 changes to the South Carolina 

Dental Practice Act. The new statutory 

scheme has now been in place for nearly 

four years. Throughout this period, 

dental hygienists have been providing 

preventive services in schools under an 

agreement with the health department—

without an initial examination by a 

dentist—and the Board has not 

reimposed its previous dentist 

examination requirement. Thus, 

although the 2003 amendments have not 

eliminated the need for relief in this 

case, they are a relevant consideration 

in determining the nature and scope of 

that relief. 

Accordingly, the proposed order takes 

the statutory change into account. First, 

requiring the Board to distribute the 

announcement set forth in Appendix A 

to all dentists, dental hygienists, and 

school districts will ensure that 

interested parties know that the Board 

has formally acknowledged that it is 

legally barred from resuming the 

conduct challenged in the Commission’s 

complaint. Second, the notice 

requirement of Paragraph II addresses 

the possibility that the Board might 

attempt to restrain competition in the 

provision of dental hygienist services in 

public health settings in ways not 

addressed by the 2003 amendments. 

This notice provision will increase the 

Commission’s ability to monitor the 

Board’s future conduct and is likely to 

help deter the Board from imposing 

restraints on public health preventive 

dental care that are not grounded in the 

policies articulated by the South 

Carolina legislature. 

As is standard in Commission orders, 

the proposed order contains certain 

reporting and other provisions that are 

designed to assist the Commission in 

monitoring compliance with the order. 

The proposed order would expire in 

ten years. 

By direction of the Commission. 

Donald S. Clark, 

Secretary. 

[FR Doc. E7–12323 Filed 6–21–07: 8:45 am] 

BILLING CODE 6750–01–S 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

Office of the Assistant Secretary for 

Preparedness & Response, Office of 

Preparedness & Emergency 

Operations; Privacy Act of 1974; 

Report of a New System of Records 

AGENCY: Department of Health and 

Human Services (HHS), Office of the 

Assistant Secretary for Preparedness 

and Response (ASPR), Office of 

Preparedness and Emergency (OPEO). 

ACTION: Notice of a new System of 

Records (SOR). 

SUMMARY: In accordance with the 

requirements of the Privacy Act of 1974, 

we are proposing to establish a new 

system titled, ‘‘The National Disaster 

Medical System (NDMS) Patient 

Treatment and Tracking Records 

System,’’ System Number 09–90–0040. 

The primary purpose of the NDMS 

Patient Treatment and Tracking Records 

System is to collect data from 

individuals using the medical care 

capabilities provided by NDMS. 

EFFECTIVE DATES: NDMS filed a new 

SOR report with the Chair of the House 

Committee on Oversight and 

Government Reform; the Chair of the 

Senate Committee on Homeland 

Security and Governmental Affairs; and 

the Administrator, Office of Information 

and Regulatory Affairs, Office of 

Management and Budget (OMB) on June 

18, 2007. The proposed SOR will be 

effective 30 days from the publication of 

the notice or 40 days from the date 

mailed to ensure that all parties have 

adequate time in which to comment. 

However, a request has been submitted 

to the OMB to grant HHS a 10 day 

waiver of the review period due to the 

impending start of the hurricane season. 

We may defer implementation of this 

system and retrieve the request for 

waiver should we receive comments 

that are contrary and requires the 

document to be altered. 

ADDRESSES: You may submit comments, 

identified by one of the following 

methods: The Federal e-Rulemaking 

Portal at http://www.regulations.gov and 

following the instructions for submitting 

comments, or send to the NDMS Chief 

Medical Officer, National Disaster 

Medical System, 330 Independence 

Avenue, SW., Room G–644, 

Washington, DC 20201. 

FOR FURTHER INFORMATION CONTACT: 

CAPT Ana Marie Balingit-Wines, Chief 

Nurse, NDMS Electronic Medical 

Records Project Officer, ASPR/OPEO/ 

NDMS, 330 Independence Avenue, SW., 

Room G–644, Washington, DC 20201. 

CAPT Balingit-Wines can be contacted 

by telephone at 202–205–8088, or e-mail 

at anamarie.balingit-wines@hhs.gov for 

issues related to the SOR. 

SUPPLEMENTARY INFORMATION: NDMS 

operates pursuant to Section 2812 of the 

Public Health Service Act (42 U.S.C. 

300hh–11), and currently resides in 

HHS under ASPR in accordance with 

the Pandemic and All Hazards 

Preparedness Act (PAHPA), Public Law 

109–417. With the passage of PAHPA, 

ASPR has been designated as the agency 

responsible for medical response to 

include the deployment of NDMS and 

Field Medical Station assets as well as 

the management of the officers of the 

Public Health Service Commissioned 

Corps deployed during a response. 

ASPR medical components, in 

particular NDMS, function in a 

coordinated effort with DHS, DoD, and 

the VA. In a disaster situation, NDMS 

and other ASPR components will 

augment the public health and health 

care activities of State and local 

governments. 

The Privacy Act embodies fair 

information principles in a statutory 

framework governing the means by 

which the United States Government 

collects, maintains, uses, and 

disseminates personally identifiable 

information. The Privacy Act applies to 

information that is maintained in a SOR, 

which is a group of any records under 

the control of an agency from which 

information is retrieved by the name of 

the individual or by some identifying 

number, symbol, or other identifying 

particular, such as property address, 

mailing address, assigned to the 

individual. As a component of 

Emergency Support Function (ESF) #8, 

NDMS has shared medical records with 

the other agencies and departments that 

comprise ESF #8, due to the Function’s 

shared statutory authority over the 

collection of medical information. 

NDMS has three key functions to which 

each of the ESF partners contribute and 

require the collection of medical 

information: medical response, patient 

evacuation, and definitive medical care. 

The medical response function of 

NDMS is related to the activation and 

deployment of NDMS response teams, 

comprised of medical and logistical 

personnel, to assess the health and 

medical needs of disaster victims. In 

response to the overall needs of the 

patients, NDMS teams are activated to 

provide physical and mental health, as 

well as evacuation during a public 

health emergency as cause for activation 

as defined in 42 U.S.C. 300hh–

11(a)(3)(A). 


jlentini on PROD1PC65 with NOTICES
Federal Register / Vol. 72, No. 122 / Tuesday, June 26, 2007 / Notices 35053 

The patient evacuation function of 

NDMS relates to the establishment of 

communications, transportation, and a 

medical regulating system to evacuate 

and move patients from a staging center 

near a disaster site to patient reception 

sites known as Federal Coordinating 

Centers (FCCs). The DoD and VA have 

the prime responsibility for activating 

and managing the FCCs. In turn, upon 

receiving the patients, the FCCs have 

the authority to arrange for necessary 

referrals and admissions or NDMS 

evacuated patients. 

CMS is responsible for establishing 

and administering the reimbursement 

process for health care rendered to 

patients provided under the umbrella of 

NDMS in accordance with Section 2812 

of the Public Health Service Act, 42 

U.S.C. 300hh–11, for ‘‘definitive care.’’

The SOR for the collection of 

information for the purpose of 

reimbursement has been filed separately 

and was published on November 23, 

2005, under 70 FR 70849. NDMS health 

care providers, in the course of 

providing health care, collect data that 

identifies the patient’s name, address, 

contact information, gender, insurance 

information, prior medical history, and 

all treatment information to include, but 

not limited to, symptoms, vital signs, 

diagnosis, and medications prescribed 

through the health care continuum. 

NDMS veterinary providers, in the 

course of providing care to animals, may 

collect contact information from the 

animal’s owner. The medical records 

could also include x-rays, lab results, 

and providers’ comments relative to 

their observations about the patient. 

NDMS has a need for the collection of 

information for health care, patient 

movement, and tracking, as well as for 

reimbursement of health care rendered. 

The collection of the data as a result 

of illness or injury from a disaster or 

other event mandating the deployment 

of NDMS medical personnel is 

accomplished through a combination of 

paper and electronic records. The 

patient data collected will also be used 

for tracking the patient through the 

continuum. The collection of 

information during an event such as a 

patient evacuation will assist NDMS in 

quickly tracking and sending the patient 

and the medical information from the 

casualty collection site to the designated 

FCC. The system will also allow NDMS 

to track how many patients are sent to 

each FCC along with their discharge and 

location status. The information will 

include but not be limited to name, 

address, phone numbers, ethnic 

background, and other contact and/or 

identifying information as well as 

medical information including 

laboratory tests performed, diagnosis, 

treatment provided, medications 

prescribed, referrals, and any treatment 

advice provided by the medical 

professional to the patient. Pursuant to 

5 U.S.C. 552a(b)(1), information 

collected would be disclosed to other 

Department of Health and Human 

Services (HHS) agencies such as the 

Centers for Disease Control and 

Prevention (CDC), the Centers for 

Medicare and Medicaid Services (CMS), 

and the Agency for Health Care 

Research and Quality (AHRQ), for the 

purpose of research, evaluation or 

epidemiologic and longitudinal 

surveillance studies related to health 

care, which may impact the care 

provided to disaster victims. 

Information in this system will be 

disclosed as ‘‘routine uses’’ to the 

following entities: 

1. Emergency Support Function #8 

(ESF #8) is a coordinated effort between 

the Department of Health and Human 

Service (HHS), the Department of 

Homeland Security (DHS), the 

Department of Defense (DoD), and the 

Department of Veterans Affairs (VA). As 

such, the medical treatment and 

evacuation of patients is a shared 

responsibility between these agencies 

and disclosure of health related 

information is necessary to adequately 

manage the overall care of the patient. 

2. Disclosure to a member of Congress 

on behalf of a constituent’s inquiry. 

3. Disclosure to the Department of 

Justice (DOJ), court or adjudicatory body 

when the agency is involved in 

litigation or has an interest in litigation. 

4. Disclosure to agency contractors, 

consultants, or grantees engaged in the 

performance of service related to this 

collection and who may need to have 

access to the records in order to perform 

the activity. 

5. To assist another Federal or State 

agency, agency of a state government, an 

agency established by State law, or its 

fiscal agent to assess the location or the 

status of their beneficiary. 

6. Disclosure to family members of a 

patient about the location or the status 

of the patient. 

The Privacy Act requires each agency 

to publish in the Federal Register a 

description denoting the type and 

character of each system of records that 

the agency maintains, and the routine 

uses that are contained in each system 

in order to make agency recordkeeping 

practices transparent, to notify 

individuals regarding the uses to which 

personally identifiable information is 

annotated, and to assist individuals to 

easily find such files within the agency. 

NDMS, as a component of the OPEO, 

which resides within ASPR, intends to 

create a separate and distinct system of 

records. Below is the description of the 

NDMS Patient Treatment and Tracking 

Records System. 

Dated: June 14, 2007. 

Kevin Yeskey, 

Deputy Assistant Secretary, Office of 

Preparedness and Emergency Operations. 

SYSTEM NO. 09–90–0040 

SYSTEM NAME: 

‘‘National Disaster Medical System 

(NDMS) Patient Treatment and 

Tracking,’’ HHS/ASPR/OPEO. 

SECURITY CLASSIFICATION: 

Unclassified. 

SYSTEM LOCATION: 

For a specified period and in 

accordance with the archiving rules, the 

paper records will be resident at NDMS 

headquarters, located at 409 3rd Street 

SW., Suite 330, Washington, DC 20024. 

The electronic copy of the record will be 

resident at the data center at the Unisys 

Corporation, 11720 Plaza America 

Drive, Reston, VA 20190. 

CATEGORIES OF INDIVIDUALS COVERED BY THE

SYSTEM: 

The individuals covered by the 

system are all persons and owners of 

animals treated by NDMS medical 

personnel when the NDMS Disaster 

Medical Assistance Teams (DMATs) and 

Veterinary Medical Assistance Teams 

(VMATs) are activated to respond to 

emergency situations, or as a response 

to any other situation for which they are 

activated. 

CATEGORIES OF RECORDS IN THE SYSTEM: 

All records pertaining to treatment 

and movement of patients to include the 

following (both in hard copy and 

electronic format): 

Category A: Completed Patient 

Treatment Record form that includes: 

1. NDMS Team Identification. 

2. Chart Number. 

3. Time and Date Patient seeks 

treatment. 

4. Triage Category and health status. 

5. Location where Patient is seen and 

transferred. 

6. Patient Identification—Name, 

Address, City, State, Zip, Date of Birth, 

Phone Number, Employment, Weight, 

Next of Kin. 

7. Complaints/Symptoms. 

8. Vital Signs/Treatment 

Recommended and/or Prescribed. 

9. Discharge—Time, Date, 

Disposition, Recommendations. 

10. Patient Authorization—Requires 

Patient Signature in Front of Witness 

and Witness Verification through 

Signature. 


jlentini on PROD1PC65 with NOTICES
35054 Federal Register / Vol. 72, No. 122 / Tuesday, June 26, 2007 / Notices 

11. Any potential attachments such as 

X-rays and laboratory reports showing 

test results. 

Category B: Veterinarian Treatment 

Records on animals: 

1. Privacy Act Data such as the name, 

address and telephone contact 

information of owners of animals will 

be maintained to be associated with the 

animal patient. However, animal 

treatment records themselves are not 

subject to the Privacy Act protections. 

AUTHORITY FOR MAINTENANCE OF THE SYSTEM: 

NDMS Statute, 42 U.S.C. 300hh–11; 

Title VI of the Civil Rights Act of 1964; 

and Section 504 of the Rehabilitation 

Act of 1973. Records disposition of this 

medical SOR is determined under laws 

governing federal records through the 

National Archives, 44 U.S.C. 3303a. 

PURPOSE(S): 

Medical and demographic 

information is collected on all patients 

seen and/or treated by NDMS or ASPR 

personnel. This SOR will also provide 

the location, time, and date the patient 

was transported during an evacuation. 

The information collected will include 

but not be limited to the patient’s (1) 

Medical treatment history, (2) their preexisting conditions, (3) their described 

symptoms, (4) any medical opinion 

rendered by an attending medical 

professional(s), (5) medications that 

were prescribed, or (6) any other 

medical advice provided. The collection 

of data contained in medical records 

provides a mechanism by which teams 

can have the ability to conduct medical 

quality assurance and establish a quality 

improvement process (QIP). Through 

QIP, teams can analyze and judge their 

performance on a specific deployment 

and if necessary enable them to better 

plan for future deployments. These 

patient records are also important 

sources of information to be used for 

research projects related to the 

prevention of disease or disability as a 

result of a disaster. Most importantly, 

these patient records document medical 

treatment rendered, especially if 

questions of liability arise about the 

treatment or the subsequent condition of 

the patient while he/she is under the 

care of NDMS. 

ROUTINE USES OF RECORDS MAINTAINED IN THE

SYSTENM, INCLUDING CATEGORIES OF USERS AND

THE PURPOSES OF SUCH USES: 

In addition to those disclosures 

generally permitted under 5 U.S.C. 

552a(b) of the Privacy Act, all or a 

portion of the records or information 

contained in this system may be 

disclosed outside HHS as a routine use 

pursuant to 5 U.S.C. 552a(b)(3) as 

follows: 

1. ESF #8 is a coordinated effort 

between HHS, DHS, DoD, and the VA. 

As such, the medical treatment and 

movement of patients is a shared 

responsibility between the ESF #8 

partnership agencies. The medical and 

demographic information collected 

during the treatment of a patient is 

shared with the partners to ensure that 

patients treated through NDMS receive 

the maximum level of health care 

possible. 

2. Disclosure to a member of Congress 

or a Congressional staff member in 

response to an inquiry from the 

Congressional office made at the behest 

of the constituent about whom the 

record is maintained. 

3. Disclosure to the Department of 

Justice (DOJ), court, or adjudicatory 

body when the following situations 

arise: 

a. The agency or any component 

thereof, or 

b. Any employee of the agency 

whether in his/her official or individual 

capacity, where DOJ has agreed to 

represent the employee, or 

c. The United States government is a 

party to litigation or has an interest in 

such litigation and after careful review, 

the agency deems that the records 

requested are relevant and necessary to 

the litigation and that the use of such 

records by DOJ, court, or adjudicatory 

body is compliant with the purpose for 

which the agency collected the records. 

4. Disclosure to agency contractors, 

consultants, or grantees who have been 

engaged by the agency to assist in the 

performance of a service related to this 

collection and who need to have access 

to the records in order to perform the 

activity. 

5. To assist another Federal and/or 

State agency, agency of a state 

government, an agency established by 

State law, or its fiscal agent: 

a. To establish the benefit entitlement 

of the patient. 

b. To establish the relationship 

between the existing state benefit and 

the benefit funded in whole or part with 

Federal funds, such as the one 

associated with the NDMS definitive 

care. 

c. To collaborate with the state and 

state agencies on behalf of family 

members regarding the current location 

and placement of their evacuated family 

member or patient population. 

6. Disclosure to family members of a 

patient about the location or the status 

of the patient. 

POLICIES AND PRACTICES FOR STORING, 

RETRIEVING, ACCESSING, RETAINING, AND

DISPOSING OF RECORDS IN THE SYSTEM: 

Category A: Patient Care Forms or 

other Medical Records: 

Records in this system will be 

retained in accordance with the records 

disposition authority approved by the 

National Archives and Records 

Administration (NARA) for the Office of 

Public Health and Emergency 

Preparedness (OPHEP) in compliance 

with N1–468–07–1. The Pandemic and 

All Hazards Preparedness Act (Pub. L. 

109–417), established the ASPR to serve 

in a similar capacity as OPHEP for 

medical disaster response. The records 

disposition authority used for these 

records will N1–468–07–1. 

Disposition authority: 

Patient Care Forms or other Medical 

Records regulated under the Health 

Insurance Portability and 

Accountability Act (HIPAA), created by 

the Federal Medical Station(s) or by any 

component of HHS/ASPR during a 

response to an event while caring for 

victims of that event. Disposition: Cutoff 

is at the end of the response activity by 

the Federal Medical Station(s) for a 

particular event. Retire to the 

Washington National Records Center 2 

years after cutoff. Destroy 75 years after 

cutoff. This disposition instruction is 

media neutral; it applies regardless of 

media or format of the records. 

Category B—The information 

collected on animals and their owners 

will not be destroyed until NARA 

approves a disposition schedule for 

those records. 

STORAGE: 

Paper records from this system are 

stored in the NDMS headquarters at 409 

3rd Street, SW., Suite 330, Washington, 

DC 20024. The electronic database or 

server where information is entered and 

stored is maintained at the HHS data 

center located at Unisys Corporation, 

11720 Plaza America Drive, Reston, VA 

20190. During deployments, NDMS 

stores the records securely in their 

deployed location, the electronic data is 

stored in a secured server, and all 

procedures required for protection of 

Privacy Act documents are 

implemented as identified in 

‘‘Safeguards’’ section below. 

RETRIEVABILITY: 

NDMS Patient Treatment and 

Tracking Records in electronic and 

paper copy are organized by event, 

location, and date of treatment. Data 

from the records are stored in an 

electronic database enabling data from 

the records to be retrievable by name 

and other demographic information 

provided by the patient (or for 

veterinary records, by pet owner), as 

well as by location of treatment, 

diagnosis, and other data fields within 

the database. 


jlentini on PROD1PC65 with NOTICES
Federal Register / Vol. 72, No. 122 / Tuesday, June 26, 2007 / Notices 35055 

SAFEGUARDS: 

NDMS has safeguards in place for 

authorized users and monitors such 

users to ensure against unauthorized 

use. Personnel having access to the 

system have been trained in the Privacy 

Act and information security 

requirements for both paper copies and 

electronically stored information. 

Information in this system is 

safeguarded in accordance with 

applicable laws, rules and policies, 

including the HHS Information 

Technology Security Program 

Handbook, all pertinent National 

Institutes of Standards and Technology 

publications and OMB Circular A–130, 

Management of Federal resources. All 

records are protected from unauthorized 

access through appropriate 

administrative, physical, and technical 

safeguards. These safeguards include 

restricting access to authorized 

personnel who have a need-to-know, 

using physical locks in the office 

environment, and the process of 

authentication using user IDs and 

passwords function as protection 

identification features. HHS file areas 

are locked after normal duty hours and 

the facilities are protected from the 

outside by security personnel. 

SYSTEM MANAGER AND ADDRESS: 

The NDMS Chief Medical Officer 

located at 409 3rd Street, SW., 

Washington, DC 20024. Mailing address: 

330 Independence Avenue, SW., Room 

G–644, Washington, DC 20201. 

NOTIFICATION PROCEDURES: 

Requests for Privacy Act protected 

information generally are governed by 

HHS regulations found at 45 CFR, Part 

5b. They must be made in writing and 

clearly marked as a ‘‘Privacy Act 

Request’’ on the envelope and letter. 

Inquiries regarding this SOR should be 

addressed to the System Manager. 

Inquiries related to patient medical 

records should include the full name of 

the individual, the appropriate personal 

identification, and the current address, 

and should be sent to the Chief Medical 

Officer, NDMS, 330 Independence 

Avenue, SW., Room G–644, 

Washington, DC 20201. The name of the 

requester, the nature of the record 

sought, and the verification of identify 

must be clearly indicated, as required by 

HHS regulations at 45 CFR 5b.5. 

Requests may also be sent to: HHS 

Privacy Act Officer 200 Independence 

Avenue, SW., Washington, DC 20201. 

RECORD ACCESS PROCEDURES: 

Same as Notification Procedure above. 

CONTESTING RECORD PROCEDURES: 

Same as the Notification Procedure 

above. The letter should state clearly 

and concisely what information you are 

contesting, the reasons for contesting it, 

and the proposed amendment to the 

information that you seek pursuant to 

HHS Privacy Act regulations, 45 CFR 

5b.7. 

RECORD SOURCE CATEGORIES: 

Sources for providing data for NDMS 

Patient Treatment Records will only be 

provided by patients, medical personnel 

treating the patients or by accessing 

their personal health records (PHR). In 

the case of minors or other individuals 

unable to explain symptoms, 

information may be sought from a 

parent or guardian. For animals, 

information will be gathered by NDMS 

veterinary personnel and/or owners or 

caretakers of animals. 

EXEMPTIONS CLAIMED FOR THE SYSTEM: 

None. 

[FR Doc. 07–3097 Filed 6–25–07; 8:45 am] 

BILLING CODE 4150–37–M 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Government-Owned Inventions; 

Availability for Licensing 

AGENCY: National Institutes of Health, 

Public Health Service, HHS. 

ACTION: Notice. 

SUMMARY: The inventions listed below 

are owned by an agency of the U.S. 

Government and are available for 

licensing in the U.S. in accordance with 

35 U.S.C. 207 to achieve expeditious 

commercialization of results of 

federally-funded research and 

development. Foreign patent 

applications are filed on selected 

inventions to extend market coverage 

for companies and may also be available 

for licensing. 

ADDRESSES: Licensing information and 

copies of the U.S. patent applications 

listed below may be obtained by writing 

to the indicated licensing contact at the 

Office of Technology Transfer, National 

Institutes of Health, 6011 Executive 

Boulevard, Suite 325, Rockville, 

Maryland 20852–3804; telephone: 301–

496–7057; fax: 301–402–0220. A signed 

Confidential Disclosure Agreement will 

be required to receive copies of the 

patent applications. 

Method for the Direct Detection and 

Quantitation of Asparagine Synthetase 

in Biological Samples 

Description of Technology: Acute 

lymphoblastic leukemia (ALL) is a fastgrowing cancer that targets immature 

cells of the blood and bone marrow. 

Clinical treatments of ALL use enzymebased methods, such as L-asparaginase 

(ASNase), for depletion of cellular 

asparagine in combination with 

standard chemotherapeutic agents. 

Although ASNase can be used to treat 

both childhood and adult forms of ALL, 

its use is limited because patients can 

often develop resistance to ASNase 

therapy. Studies have shown a 

correlation between ASNase resistance 

and increased expression levels of 

asparaginase synthetase (ASNS) 

enzyme, which catalyzes the 

biosynthesis of cellular L-asparagine 

from L-aspartate in an ATP-dependent 

reaction. At present, measurement of 

ASNS expression levels are based on 

mRNA or antibody based assays; 

however, these methods are not suitable 

for direct quantitation of protein in 

biological samples. Thus, new and 

improved methods that directly measure 

ASNS protein levels are needed. 

Researchers at the NCI have 

developed novel methods for 

quantitating ASNS protein in biological 

samples using isotope-labeled standard 

peptides and mass spectrometry. The 

current technology describes methods of 

identifying a patient with cancer or 

chemoresistant cancer, monitoring the 

treatment regimen of a patient with 

cancer, as well as methods for detecting 

modulators and their ability to affect 

ASNS expression levels. Further 

described are novel pharmaceutical 

compositions with potential use as 

chemotherapeutic agents. 

Applications: Diagnostic assay for 

leukemia or chemoresistant cancer; Use 

in screening or identifying potential 

chemotherapeutic agents; Use in 

measuring a patient’s sensitivity to 

ASNase therapy. 

Market: Approximately 5,200 people 

are diagnosed with ALL each year in the 

United States; ALL is the most common 

type of cancer in children in developed 

countries. 

Development Status: Early stage. 

Inventors: Thomas P. Conrads (NCI/ 

SAIC) et al. 

Patent Status: International 

Application No. PCT/US06/28965 filed 

25 Jul 2006 (HHS Reference No. E–189–

2006/0–PCT–01). 

Licensing Status: Available for 

exclusive and non-exclusive licensing. 

Licensing Contact: Robert M. Joynes, 

J.D., M.S.; 301–594–6565; 

joynesr@mail.nih.gov. 


jlentini on PROD1PC65 with NOTICES