EPA Reg. No. 264-418

Vol. 1

(this copy does not include records prior to 

April 1991)
RHONE·POULENG AG OOMPANY 

Ms. Terry Stowe 

BPA Registr"tlon Division 

TEAM 22 

~.;"'.lj$~ [It,S 

_"" ± _""4 "" ... 

November 19, 1993 

RE: PREP<~ Piant Regulator For Cotton 

EPA Reg. No 264·418 

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Based upon your phone me~sage of November 19, 1993 piease be advised that we do 

request an expedited review for the Prep alternate formulation request. The 

submission was initially !ll~d on January 30, 1993 and simpiy removed the additives 

that wete used as markers \0 identify the source of supply for the active ingrdient in the 

formulated product. . 

• As • prerequisite to .pprov~l of the amended formuiation for Prep we were asked to 

amend our basic formulatl<)n to identify the source of suppiy for etIlepIlon. TIlts action 

was compieted with an EPA acceptance dated November 8,1993. We now have 

immediate need for the a1t~rnate formuiatlon approvai to allow manufacture of our 

1994 Prep Piant Reguiator Inventory which is set (0 begin in mid January, 1994. 

We wouid appreciate EPA ~PPl'oval of the alternate formulation for Prep as soon as 

possible. If you have any ~uestiollS piease contact me prompUy. 

Thanks for your heip. 

&I~,. A' .tbv~ 

• Warren A. I)avis 

Senior Regi!;tratlon Manager 

POBOX 12Q14,21W N.f ~Nif;!} .. af"\\'(t 

m:SEMCHTI'IlANG:EPARf{ rIC ;'7WJ 

, 

(1II9)MrHOOO I 

l"ItEIl,"iAlIONAL lEt!;X !rJ',~m 11 ~9)"~1b·'A1';$1~(fl\1I'1f, J,,,C j>:P • • ttJt£I'WAHOUAL f)1f;'RIHV;;?'1.'>[ R'IIC,S TEl f)( N\JVur n ~S:;n:;lf .Al .. SWf q[IAO'; rrc "y, 

1 
FROM RHOil[-POULEHC pj CO-EPG'C 

""'",._:w ,s:_ .. 

RHONQ·POULENC AG CpMPANY I 

ENVIRONMliNTAL,REGULATony & PtroLlC AFFAIRS DEPARTM1lNT 

PO Box 12014,2 TW Alexander Drive ' 

Research Triahgle Park, N.C. 27700 

Fax Number: (919):549-2545 

URGENT,.k.. YES _ND 

! PAX CO\,ER SHEET ==:J 

DATE:.-.L/ / /fIP 5 

FROM: Wlll'll1<lV QIlv,.i--': TELEPHONE NO. 1"/2 - sf'? - ,U? f 

• TOTAL NUMBER OF PAGES (INCLUDING THIS SHEET): _ ~6". ____ _ 

., 

If message Is nollc{;lble or all pages n6t re<:eived, please advise us by fax or ph:)nc. 

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MESSAGE: 

R£'6.l{("> T ro.r'C ex('er.;/:feJ} /2eu/C?cd f,t</' j:'o,v."t."jje,,, 

/Jm",v",,,,e,,- T _ 

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(i! RHONE-POULENC 

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RHONe·POULENC AG COMPANY 

Document Processing Desk (FIN-LABEL) 

Office of Pesticide Programs (H-7504-C) 

U. S. Environmental Protection Agency 

401 M Street SW 

Washington DC 20460-0001 

November 3, 1993 

Attention Mr. Jim Tompkins 

RE: Worker Protection Standard 

Final Labeling for: 

ETHREL brand Ethephon Plant Regulator for Pineapples and Sugarcane 

EPA REG No 264-257 

PREP brand Ethephon for Cotton and Tobacco 

EPA REG No. 264-418 

Thank you for your prompt response for the above referenced labels. The proposed 

changes have been made and final labeling is appended to document the changes. 

Please note on the PREP label there is a new _section that addresses the use of recydable 

containers that was not in the original label med as part of the WPS compliance. To 

document that this wording has now been approved by EPA we are appending the 

Agencies acceptance letter. 

If you have any questions please contact us promptly . 

Warren A. Davis 

Senior Registration Manager 

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Hr. Warren A. Davis 

Rhone-Poulenc Ag Company 

P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle park, NC 27709 

Dear Mr. Davis: 

.., Subject: Returnable containers 

• 

PREP Ethephon Cotton Boll Opener 

EPA Registration No. 264-41B 

Your Submission Dated October 15, 1993 

The amendment referred to above, sUbmitted in connection with 

registration under the Federal Insecticide, Fungicide and 

Rodenticide Act (FIFRA), as amended is acceptable provided that 

you: 

1. Make the labeling changes listed below before you release 

the product for shipment bearing the amended labeling: 

In the Environmental Hazard section delete "For terrestrial 

use,", Refer to PR Notice 93-8 • 

2. Submit one (1) copy of your final printed labeling before 

you release the' product for shipment. 

A stamped copy of the labeling is enclosed for your records. 

Enclosure 

Sincerely yours, 

{ /cl, ---~ 

Cynthia G'les-Parker 

Product Manger (22) 

Fungicide Herbicide Branch 

Registration Division (H7505C) 

4 
PRE P TM BRAND ETHEPHON FOR COTTON AND TOBACCO 

For Commercial Use Or Agricultural Use Only. Not For Residential Use 

ACTIVE INGREDIENT: Elhephon (2-Chloroethyl) phosphonic acid" " ...... » .................. ,., ......................... 55.4% 

INERT INGREDIENTS: ........................................................................................................................... 44.6% 

·This product contains 6 poundS ethephon per calion. 

EPA Reg. No. 264·418 EPA est. No. 264·PA·01 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

~;;;;~;;;;;s;;;~;IOO~~'!'ii!ji!!I~!\!;l!~~!i;!l!:;i!iii .18a and 4.:240 ..• 19:. tlconso is gtantod [i to USGS uso this ar. product j~~~~~~~:~~:~~~a othor 

contomplated by this [abel. Liability lot paton! inltingoment may rosutl from us. or ute of this 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EYES: Hold eyelids opon and ftush with a gantkl stroam of walor lot at least 15 mlnutos. Gol medical attontion, preferably on 

ophthalmologist. 

IF ON SKJN~ Immediatoly wash skin with plenty 01 soap and water. 

IF SWAllOWED: Do not induco vomiting. Promptly drink a largo quantity 01 milk. egg whitoll:, glliatin solution or if thosa ate not 

a .... ailablo, drink large quantilios of wator. AvoKl alcohol. can a physician immodialely. 

IF INHALED: Romove victim to Iresh air. If nol breathing, give artificial respiratiOn. Administer oxygen if nGCGssary. Gol medical 

attantton. 

PRECAUTIONARY STATEMEtlTS 

DANGER 

HAZARDS ro HUMANS AND DOMESTIC ANIMALS 

_

CORROSIVE. Causes eye and skin damago. May bo lataJ if absorbed through skin. Harm: ... , II swallowod or Inhaled. Avoid broathlO9 

pray mist. Do not got In oyes, on skin or on clothing. Koep aWlir{ from domosllC animals. 

OTE TO PHYSICIAN 

Thor. IS no spocific antidote. All Iroalmont should bo based on observod signs and symptoms of distross In tho patlont. OVGre)(posUie 

10 materials othnrthan this product may havo occulted. 

Victims of sovero oVere)(posulo, by lnhalation, should bo kept under medical obsoJVation for up to 72 hours for dalayad onsat of 

pulmonary edama. In a victim 01 over-G)(posuro by ingestion, careful gastric lavage is required duo to Iho possibility of stomach or 

esophagoal perforation. This material is an acid, but uso 01 alkalino substancos to OQulratize it is rontraindfcaled. 

PERSONAL PROTECTIVE EQUIPMENT (PPE) : ••• :. 

Applicators and other handlers must woar rov.ralls over short·sk)ovod shirts and shorl pants. waterproof glo.Jas, chemical·rosistant 

footwear plus seeks, protective eyewear. chemical·resistant headgoar lor ovarhead exposuro and chGmicar:r.pI~~,r:1 t'pIon whon 

cleaning ouipment. : •• :.: • 

Discard dothing and olhar absorbed matetialslhal have boon drenched or heavily contaminated wilh-tlVs product~ ronc..Tntrate. Do 

not rouse them. Follow manufacturer's instructiOn!> for ctaaning/maintaining PPE. II no such instru.alQQ$Jor washablos, use dot01:crt 

and hoi water. Kaop and wash PPE separately trom athor laundry. : : 

Whon handlers use closed systems, onclosed cabs, or aircrafl in a manner thai moals tho requjrefTl~,n.tilist&d in:'tVl' :~n..tlr Pr~t~.i,,}'l Siandard (WPS) lor agncultural peslicidas [40 CFR 170.240 (d) (4-6)1. Iho handler PPE requirement. may be reduced or modtft~ ..... 

specified in tha WPS. ..:.. • • 

should wash hands bafora aating, drinking, chewing gum, using tobacco or using the loilol. 

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ENVIRONMENTAL HAZARDS 

Fot IOUGSlnal uses, do n01 apply diroclly 10 waler, or to amas whore suriaco walet IS crason! or to Intortldal aroas bolow tho moan high 

waist mark.. Do not conlammato WalGf whon disposing of Gquipmont washwstors. 

Do not contaminate wator usod lor irrigation or domostlC purposes. 

USE PRECAUTIONS 

00 not apply PAEpm brand Elhophon through any typo of irrlgstion system. 

Avoid spray drlft 10 noarby crops as this product will causo modilications In plant growth. Plant Injury or reduced yiGlds wiH r"ult. 

00 not plant anothor Crop wllhln 30 days after troatmont 

Mile only tho amounl of spray you Ol(poct to uso oach day, 00 not allow mixod solution to $land ovornight. 

DIRECTIONS FOR USE 

It I •• violation 01 Fode,al Law to u •• thl. product In a mann., Inconsl.tonl with Ita lab41llng. 

R.ad enttr. labal bofor. using thl. product. 

00 not apply this product in a way that will contact workors or othot porsons, Glthor dltectly or through drTtt, Only protGCteci handlers 

may be in tho area dUting application. For any requirements specific to your Stato or Ttibo. consult the agoncy responsibla lor 

posticido rogulations. 

in~'iCOO~rd~;."'~C~.iW~'~"h~"'~': . ot 

training, 

~J:~""~ wotko~ ~ng decontamination, and with on farms, the Workor forosts, 

notlflcatlon, 

Protection nutserles, 

and Standard, emergency 

and graanhousas, 40 CFR 

assistanco. part and t70. It 

handlers This 

also ~~~~~:~~~I to the 5tatemants on this label about p1)rsonal protectIVe equipment (PPE), 

requirements in this box only apply to uses 01 this product that ara coveted by tho 

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not enter or allow WOlker entry into treated areas duting tho rostricWd-antry intervat (REI) 0148 hours. 

required lor eatly ontry to treated aro .. that Is pormitted under the Worker Prot&CIion Standard and that involve. contact 

that has be.., treatocl such as plarrts, soil or water is covOl'alis OVOI short-sloeved shfrt and short pants, W'''.,p''''oI.Io~.',1 

i footwear plus ~, PfOtOC1ive oyowear umfc:hoinical·resiutant headgear tor ovorhoad oxposure, 

STORAGE AND DISPOSAL 

I'T,ng""E 

100 not contam; 1ato W' ,000t. food, ot food by storage 1'( .:-,pos ..... 

container is b.::~;'" or contents have spilled, follow all procautions indicated above and cIoan up immediately. Bofote c"O< ,.,; 

on ful/length trousers, long sleoved shirt, protective glovos, and gogglos or faco shield, Soak up spill With absorbent meaia 

sand, earth or othor sUltabla material and dispose ot waste al an approved waste disposaltllcWty, 

OISPOSAL 

,~!;~;;::w~as~Ji.~:'~'::'~.iac~~utely hazardous. Improper disposal of excess pesticide. spray mixtura, or nnsato is a violation of Fed.raJ law. be disposed of by use according to labol instructions, contact your Stato Pesticide or Environmentat Cont",,1 

Waste rGprosontative at tho noarest EPA Regional Office forguidanca. 

CONTAINER DISPOSAL 

Triple rinse (or equivalent) the empty containers. Thon offor fot toeycUng or reconditioning, or puncture and disposs 01 in a ... n"''Y1 

landltll, or by inclnetation ot if allowed by stale and local authorities. by burning. If container is burned, stay out at I~. 

RETURNABLE ~~ REFILLABLE CONTAINERS • 

return tho container to the point ,.til"''''''''P! ":::n~~~1 tor Cotton and Tobacoo. DO In 

for damage such as ctacks, 

GENERAL INFORMATION 

COTTON 

on II 

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A foliar sptay of PREPn. brand Ethophon will accelerato opening 01 mature unopened cotton bolls and onhanca..d.I~I~Ior. whict! c.... r 

r.sult in Garliet harvest with an rncrsasod roco-verabfa yield. PREPTW brand Ethophon troatmont on cotton ailOws"lttcMsod oHici."CO;' 

from a once-ovet harvest. 

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TOBACCO (FLUE-CURED): A loHar spray of PAEP"" brand Ethophon promotos early. uOiform "yGUowing· of mature tobacco. 

PAEPnI rMUCH cunng 11m •• allowing moro officium use 01 cunng Darn spaco, ana Incroased control ovor harvest schedulos. 

SPRAY PREPARATION 

Add 112 to 3/4 01 tho r&quir&<:! amounl of wator to tho spray tank. Slart agitalion. Add tho roqwroo amount of PREpnI brand Elhophon, 

and tha romaining amount of water, PreparG only as much spray solution as can bo used on tho day 01 mixing. 00 not allow spray 

solution to stand ovornlght. Do not spill tho concentrated product on ~ray OQUipment, or any airplano parts. 

ANY SPILLS SHOULD BE RINSED IMMEDIATELYWfTH PLENTY OF WAlEA. 

Use 01 a nurso tank [s hlghlV recommonded lor avoiding possiblo spills of concontrated formulation on spray equipment or any airplane 

part.s. 

TANK MIXTURES WITH DEFOLIANTS AND INSECTICIDES 

PAEpnI brand Ethsphon is compatlblo with DEFt. FOLEX., Droppz, Harvad.3, Mothyl Parathion, GUlhion1, and MaJalhion~. PAEpna 

may bo appllod in soquence or as a tank mixlUro (DO NOT TANK MIX WITH DESICCANTS IF COrroN IS TO BE SPINDLE 

HARVESTED), Follow all appIicab14 U"o precautions and rate por aero recommondations on labofs of products applied as tank mixtures 

or in sequonco with PREP 'nI brand Ethophon. In soma cases slight reduction in boll opening response has baon observed when tank 

mixes with deleliants WOte used. 

Good agitalion in the spray tank is essential and a tank minura should not bo allowed to sland without agitation lor mom Ihan 510 to 

minUlos, Road and ObsCHVO all appropriate Jabal use directions and procaubons for Iho dololianl$ and insftdicido. used. 

NOTE: Under certain conditions, tank mixtures of PREPN brand Eth&phon with dosiccants containing sodium chlorate could 

rosult in tho lormation 01 hypochlorous acids which on hoatinq wi" omit toxic chloridelumes. 

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UIPMENT CLEANING 

cause ot tho acidic natura 01 this product, prolonged exposuro 10 spray deposit will damage acrylic plastics. cerlain paints, and 

taJs. 

Ainu thoroughly with a detergent and wator all exposod acrylic plastic·typo matorials (o.g .• aircraft windshiolds), and painted surfacos 

within an hour after exposure to spray dOpcnillS. 

At the end of e.en day, rinse thoroughly with a detergent and water aU tho motal parts of tho aircraft and tho 8s30cialod spray 

equipmont oxposad to tho spray dOp<)S!1s. 

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COTTON 

EXPECTED PREP"'" ONE SPRAY VOLUME APPLfCA TlON 

USE CONDITIONS RATE GALLON (Gals/A) TIMING 

::EE!T";; 

i LBS A~I~ AI," 

PREPl\I Hot and dry 800F or 11/3 1.0 • Apply when Iho numb.r ~ 

8011 Oponer· higher mature unopenod bolls. is: 

Dry and 75 to 8QeF 2 1.5 4 15~50 2~5 

su/licionl to tho 

d""odo~oi :"_below~ lor 

Cool but aboVe 6SeF 22/3 2~0 3 tOSI 01 I 

Treatment ' open, 

Rank "".~n bolls 710 14 days o.vu8t. 

PREpno + High soil moisture 1/3 O~2S 24 15 ·50 5 - 10 i ;'lr.rp~ 10 7 days prio~ 10 FOLEX* or boll j 

Dofal/ant Tank High fertility lovol To I U.~od~ 

Mix or i ~ot i~, ~~~lf:", W':i 

Rank ""rton I 

Dropp2 High sort moisture 1/3 0.25 24 la-so 3 - to Apply <4 to 7 day. prior to 

Tank High lortility levol PREpTW boll opening 

MIX Rank cotton 

appHcation. To be used as 

a s~u;,=tr •• lmont with, 

not in of PAEpno boll 

Pr.~CQndUlon.r Hot,dIY,:Wow 80·F 2/3 O~5 12 Apply 4 to 7 days prior to 

'0' O.follatlon 0001, abovo.SS-F 11/3 1.0 6 15 -50 2~5 defoliant. Enhance. top 

crop d./oU.llon reducing or deterioration of bottom_:~ Rank cotton and allows for - ~~~iiGr 

·Pretreatment With Defoliants PrIor to PREpllI Boll Opening TI8aUJh .... 

Illhe cotton :s ovarly r: lnk or Itying down in Iha middles and good spray coverag. :)1 the bolls .vith PREPl\I is. difficult. a pratteatmMt 

with do#oHa;I.1 will b(II :.I40lull0 hTlPlOVO boll coveraga with PAEpn.!. Use dosage rat'lS 01 PREpT'! brand Elhophon rocomn'end&d lor JOB 

opening. to...J ana ousorvG aU approprf3le label use dirodions and precautions 10' ·tho'del,:,';'nl used. 

oolf'! California and Arlrona use a volume of no loss Ihan 5 gaBons por aero lor aeria ,..~n:carions. 

AoIJ Maturity 

~" is malure when It IS 100 hatd 10 be donrad whon squo&zod oolWeen Ihumb and lingo/"$, too hard to bo sliced with a sharp knife, and 

when the seed COat bocomosUghl brown in color. 

Use LImitations 

Do not QXcood II maximum of 2.0 lb. aiJA for combined usos of PAEPTI<" por acre por yoar, 

BoU Opening: Do not tank mix PAEpTI<" brand Ethophon with a dosicc:lnl if the cotton is to bo spindlo harvestlKi. 

Pr • ..condition lor Defoliation: Do not tank mil( PAE?m with dosiccants unlo8$. plant desiccation is required. 00 not use B defolianr 

beloro there IS sufficient mature unoponed boUs 10 produco tho dosired yiold ($90 Gonorallnlormation soc1ion on h~ to losllor boll 

maturity. ! ..... 

WHEN TO HARVEST COTTON : ••• !. 

Do not harvost cotton sooner Ihan 7 days after a trealmont with PREprw brand Elhophon. : •• :.: • • •• • 

Observo the trGated crop and harvosl whon optimum boll opening has been reachad. Too oarly harvbt m~t roduca Iho Iud advantlJqo 

01 tho rrOalmenr and too laro III harvest may rosult in reduced quabty and loss of linrwhich will drop IrdI1'!)"'~lanl 

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PREpnI 

Crop SHuatlan Plnts/Acr. 

Ol/octad Spray 

ApplicatIOn 

DvM-Tho-Top 

Application 

USE LIMITATIONS 

1ti3 

t 113-2213 

so·so 

4O-SO 

TOBAcco 

(Flue-Cured Only) 

Spacflfc Olractlona 

Us. drop nozZlas, Chooso TG or DC spray tips dosigned to • 60 

9pa at 35·40 psi and at tractor speed oj 2-3 •. c,.. Us. 

2 nozzles por row; one on each side oj tho row dropped bw direct 

tho spray· to Iho loaves to be ripe nod and harvo$lod. 

is Gssonlial. With a diroctod spray, be sur. 10 harve.t 

I 

Troat only whon loav •• romaining on tho atalk are maturo. To onlur. 

remaining faaves are mAturo, loat spray sovoral tobaec;o plants 

describod under tho aoction ·Propor Timo of Tr •• mont.· Usa tho her 

in a normally mature crop whon oJq)erionce indicates that minimum ~:~:~ I 

fnducomont is roquirDd. Uselho highor rat8 when the crop is heavy ~I 

a tendency to bo mora rank or whon temperatures are Iowar than 

Always 1851 spray to detormine if Iho lobacco is malure onough to ';;;~nd I 

10 trealmant with PREf'lV brand Elhophon. 

Apply brand Elhephon spray as II line rnml 

nozzles (ono tha plan!:, and 

so aJl loavos are to tho 

00 nol apply PREpm brand Elhephon to immalura loaves as this can result In unsalislactory coloring, weight loss and reduced laaf 

quality, 

00 nol allow tho Clop to ovor Tlpen in Iho lillld atter usiog PREptW brand Elhophon, sinee this may causa somo reduction in yit'ld and 

quality. 

00 nOI troal boloro anlicipatod major storm which could prev.tIt harvesl and rDsu/t in crop loss. 

Do not apply PREprw brand Elhopl'ion if rain is expected withln.4 hours. 

APPlIC.A":.v:: TIMING 

SUCCCIssl' ,I rosults Wi h PREplW calf for Ireatmenl whon loaves are mature. nol overly rank groGn whon sprayed. To '~asify 0\0\1$. mine 

the plOJl'.r 'traiiirriont jming and the number 01 ~eavO$ por Stalk re:Jdy for harvest. lost spray sev.,..J plants In more th' ,n ono !ccat .:m in 

each fW~ j an(t09s .... ~etho response. Matwe '","lves wiI' :'ogin to .,e!bw in 24 to 72 hours. Tost loaves that lail to yelw'w in 72 hOl". era 

not mat' re arv' aro not ready lor PREpn.c ... 4n ... Etha"hon troatmont. Wait ill low days to permit lurther natural mf :<JrinQ, ":~rt make 

another. ~~ . _pray or ~malurity· checJo;, 

t: YOU have conlirmed tho numbor 01 leavos por plant that wiff color, you can dotormina Iho numbor 01 acros to Ireat in ordor to fiff 

,no 

ro your tosl spray by mixing ono tonspoon 01 PREprw in t quan 01 wator. Spray oach lasl piant with about t oz. of this mixture. 

covoring all /eaves with a fino mist. PAEpnr brand Elhophon wiff nol color immature sprayed loaves. 

WHEN TO HARVEST 

All maturo, sprayed loave. will begin to color within 24 to 72 hours alter PREpn.. brand Ethephon application, The yollowing prcx:eu is 

weather dependant; cool weather WIll delay, while hoI. sunny woalher can speed up tho process. Harvest treated tobacco when loaves 

havo raachad the dosirad color imons/[,(, 

Do not allow tobacco to become ovor ripo bolore starling harvesl LaM drop can OCCIJr when tobacco is ovar ripe '\,nd left on the stalk, 

If a numbor 01 tho bo«om leavos have yelloWed allho time of trealment, Ihey should be harvosted prior to spraying<WittJ. PREPrw brand 

Ethophon, -

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With an over-Iho-.lop applicalion, harvosting can oommonco 24 hours aftor PREpnr brand Elhephon app1i;4f#:ln doOiMitlO on wutl)"r 

cooditions or to avoid over ripo tobacco. Tobacco harvostod 24 hours after treatment will require mont!lim, iQ Ihe conr'llg p~ase o. Iho 

curing process, - -

CURING PREpn.c TREATED TOBACCO .. :--: 

Curing proceduras are as much an art as a scmnco ana' oach cure must bo iudgod on tho basis of 10baOOQ.,COnditiar., :r.I.);'\'al bolv:ccr 

Iroalment and harvest, weather and type of curing lacifity bolore prescriplion lemperaluro and.v.o.nailation ~Ies can: l'r 

established. To obtain maximum quality, care must be takan to observe end conlrol the curing procoss!cloSOIy, osre<;iallY during Ih'" 

lalo ·colorrng· and early ·drying~ siagos 01 the IGaf. ••••• __. 

PREpn. brand Elhephon Iroaloo tobacco will have statted tho coloring process when harvested, reducing tho time rooUlJed'in the 

coloring phase 01 curing, Treatoci tobacco should bo dried faster, tf tobacco f9aves aro green or oontain some groen.wl.oll:larvos:t:=, 

it may be necessary to color thorn lor a few hours, fl the leaves ate completely yollow. temperatura and vantijafion rftw."bl adjUSle'j in 

a manner to dry the lobacco as last as possible wrthout scalding. Once tho loaf is dried (314 dry), you should 10fJow l'I,)rm-u rrocedUIllS 

lor curing. Since PREpn.c brand Ethophon troatoo leavss cure fastor, Ireated and untreatod loaves should not be cured togathor in tho 

same barn. 

10 
, 

LIMITED WARRANTY AND DISCLAIMER 

Tho manufacturer warrants (a) that this product conforms to tho ci10mical doscriplion on tho tabol: (b) that this product is roasonably lit 

fot tho purposes sol forth in Iho directions lot use when f1 is usGd in accordanco WIth such directions; and (c) that tho ditoctions, 

warning and olhor statemonts on this label at. based upon tO$pOnsible experts' .",alualion of toasotlable tests 01 otfectivornlnl" 01 

toxicity 10 laboratory animals and to piants, and of residuos on food crops and upon reports of field experionco. Tosts have not boon 

made on all vatietiGs at in all stales at undor all conditions. THE MANUFACTURER NEITHER MAKES NOR INTENDS. NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES. EXPRESS OR IMPLIED. AND IT 

EXPRESSLY EXCLUDES ANO DISCLAIMS AlllMPUEO WARRANTIeS OF MERCHANT·ABILITY OR FITNESS FOR A PARTICUlAR 

PURPOSE. 

THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND ALL LOSS OR 

DAMAGE WHICH RESULTS FROM THE USE OF ntIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE LABEL 

OIRECTlONS. WARNINGS OR CAtJTlONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SElLER'S EXCLUSIVE LIABILITY FOR ANY AND All CLAIMS, 

LOSSES. DAMAGES, OR INJURIES RESUL nNG FROM THE USE OR HANDUNG OFiHlS PRODUCT. WHETHER OR NOT BASED IN 

CONTRACT. NEGLIGENCE. SlRlCT LIABILITY IN TORT OR OTHERWISE SHAll. BE UlAITED. AT THE MANUFACTURER'S OPTlON. 

TO REPlACEMENT OF, OR THE REPAVMENTOF THE PURCHASE PRICE FOR, THE OUANTTIYOF PROOUCTWITH RESPECT TO 

WHICH DAMAGES ARE CLAIMED, IN NO EVENT SHALL MANUFACTURER OR SEllER BE LIABLE FOR SPECIAL, INDIRECT OR 

CONSEQUENTIAl DAMAGES RESUL TJNG FROM THE USE OR HANDLING OF THIS PRODUCT. 

NonCE TO BUYER 

Purdlne of this product does not comOf' any tights undor patlonts goyeming this product Ot tho use thoroo1 in countrlaa outsido of tho 

United Statos. 

l,EF oOd G,'IWn ". <09 .. '&<00 tradom""'" 0/ 8ay.' AG, Go,mon,. 

lOropp IS a tegisteted tradomark of NOR-AM Chomical Company. 

3Harvada is a rogisteted tradomark of Uniroyal Company. 

~Malathion Is a trademark of American Cyanamid Company . 

• 

Rh6no-Poulanc Ag Company 

P.O. Box 12014, 2 T.W. Aloxander Drive 

Rosoatch Triangle Park, Not1h Carolina 2n09 

PREP is Iho tradomafi( of RMne-Poulorn:. 

FOLEX is a registered tradomark of Rhone·Poulenc . 

PREPTIl brand Ethophon for Colton and T obrux;o (PENDING) Submittod 10ftS!93. 

• •••• • . .. " 

• 

•• . •••• , . 

" .' ... , , , . •• ••• 

, , ....... 

, 

, . ... ... . 

, " , , 

• ••• 

. , " 

•••• 

. , , ., 

11 
f~ 

~ RHONE-POULENC 

• 

AHONE.POULENC AG COMPANY 

Effi93-30 

November 3 ,1993 

U. S. Environmental Protection Agency 

Office of Pesticide Program Document Processing Desk 

Room 266 A, Crystal Mall No_ 2 

1921 Jefferson Davis Highway 

Arlington, Virginia 22202 

Allention: Ms. Cynthia Giles-Parker 

Product Manager (22) 

Fungicide Herbicide Branch 

Registration Division (H7505C) 

Dear Ms. Parker: 

RE: PREP® Brand Ethephon For Cotton and Tobacco 

EPA Reg_ No. 264-418 

AppendedAs-..ftnal label f~""the above referenced product. The amendment approved 

added r~ycla.1?!e::.d:mraTners to the directions for use. As requested we have updated the 

label to include the most Terrestrial statement required by PR notice 93-8. We appreciate 

your rapid approval for this label amendment. 

• Sincerely, 

/1/ /: /' ·t/fa.(~-. #,£Q.( 

'i\/arrcn A Davis 

Senior Registration Manager 

?{) 2/,t lc;)~4 2 PI. kJ:'-';,M,l""-'- '.;F' >" 

RfSI:'AJiCH14[i,.IC,'f PN> r;c. ;,(Mi 

19;Jj~Hj)20J0 

if.fTEflxAL{)rMl .t', .... ,' Hh\(~. !.< __ ~T 

hl[RNfonONAL 'l'_, F. i.' ~" li(Fi' ~·,,·!\i' "L·.,\\";r'''i<~ M ,,' 'L~ 

• • •••••• 

• 

• • ••••• • 

• 

. • , . 

• 

• ••• 

• . , •• . 

• 

. • ••••• ., • • 

• ••••• 

• . • , 

••••• • • ...... • 

• ••••• • ., • 

• •• • ••••• 

,r, ).'L:e;rc.';CG",~'!P.<i;'i _1.':-< ;~'.~ ••• 

ny-jc ':. ,i":'h':;'.e'ner1! · .'. - •••• 

12 
• 

• 

Mr. Warren A. Davis 

Rhone-Poulenc Ag company 

P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, Me 27709 

Dear Mr. Davis: 

Subject: Returnable containers 

PREP Ethephon Cotton Boll Opener 

EPA Registration No. 264-418 

Your Submission Dated october 15, 1993 

The amendment referred to above, submitted in connection 

registration under the Federal Insecticide, Fungicide 

Rodenticide Act (FIFRA), as amended is acceptable provided 

you: 

with 

and 

that 

1. Hake the labeling changes listed below before you release 

the product for shipment bearing the amended labeling: 

In the Environmental Hazard section delete "For terrestrial 

use,lI. Refer to PR Notice 93-8. 

2. Submit one (1) copy of your final printed labeling before 

you release the product for shipment. 

A stamped copy of the labeling is enclosed for your records. 

Enclosure 

sincerely yours, 

(s ) 

Cynthia G~eS-parker Product Manger (22) 

Fungicide Herbicide Branch 

Registration Division (H7505C) 

13 
• • TM PRE P BRAND ETHEPHON FOR conON AND TOBACCO 

For Commercial Use Or Agricultural Use Only. Not For Residential Use 

ACTIVE INGREDIENt: Ethephon (2-Chloroethyl) phosphonk: acId· ., ...................................................... 55.4% 

INERT INGREDIENTS: ........................................................................................................................... 44.6% 

"This product contains 6 pounds elhephon per gallon. EN ___ O EN~ __ ~ 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO ~Xf~iq"- a usled on delalla, 

1·000-334-9745 

us_ 

U.S. Patents andt.:,4ii.811.: ,,- to usa this product in counlrlos othor than the or for any 

• 

use nol conlempJalod by thIs 

Slat85, 

Inlringoffionl may rosult from use or sale of thIs product outside tho UnitGd 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EVES: Hold oyolkfs open and lJush wkh a genUa slream of water for 311035115 minUI&s. Gel medical attention, preforably an 

ophthalmologist. 

IF ON SKIN: lmmltdJaloly wash skin with plonty 01 soap and water. 

IF SWALLOWED! Do not induCG vomhing. Promptly drink a largo quantijy of milk. 099 whites, golalin solution or ilthose are not 

aVailable, drink largo quanlill$$ 01 wator. Avoid alcohol. Call a physician Immediatoly. 

IF INHALED: Removo victim to Irash aIr. II nof breathing, give artificial respiration. Administer oxygon if necessary. Got msdicaJ 

allontion. 

PRECAUTIONARY STATEMENTS 

DANGER 

.iAZARDS TO HUMANS AND DOMESTIC ANIMALS _ CORROSIVE. Causes &ye and skin damagG. May bo falallf absorbGd through skIn. 'Harmlul il swalJowod or Inhaled. Avoid breathing 

• 

tpray mist. 00 nol got in oyes, on skin or on ClO1hlng. Keep away from domestic anImals. 

'NOTE TO PHYSICIAN 

, There Is no sp&cific antldoto. AU tmatmenl should be basad on observ&d signs and symploms of distress in tho patient. OJorexposuro 

to matorials other than thIs product may havo occurrod. 

Victims 01 savore overexposure, by Inhalation, should be kept under medical obsorvation lor up to 72 hours for dalayod onsot 01 

; pulmonary odoma. In a victim of ovor-i)xposuro by ingestion, careful gastric lavage Is required due to the possibility 01 stomach or 

, esophageal perforation. ThIs materIal Is an acid, but ose 01 alkalino subslaneGa to neutralize it is oonlraindicated. 

PERSONAL PROTECTIVE EQUIPMENT (PPE) 

Appllcalors and othar handlers must wear covoraUs ovsr short·swov&c! shlrls and short pants. watarprool gloves, ~!lPJT:~al.r~u.istant 

lootwear plus socks. prot&clivo eyewear, ehomlcal·rosistan\ headgear for overhead exposuro and chomlcal-ros:stant apron when 

eloanlng eulpment. ~ , •••• 

DI,card clothIng and othor absorbed materials Ihat have boon drenched or heavily contaminatod whh thIs products oo,lcantrate: .. {)o. ~ not reul8them. Follow manulacturer's inslructions for cloaning/maintalning PPE. If no such instrudions for washablos(us& dotergLnt ~ 

and hot water. Koop and wash PPE separately from othor laundry. " •• 

Whon handlers use closed sysloms, onclosed cabs, or ajrerait in a manner thaf meels Ihe roqulrements listed In the Workor Prot~Ii>!l. ~ 

Siandard (WPS) lor agricultural pesticidos [40 CFR 170.240 (d) {4-6)J, Iho handler PPE requ!ramonls may be redui:eo'or .modilied 3l'1 

spocilioo fn the WP$. 

r--------r=c::c;S-;;;j=-c.;====:::------,:-:-;---C.-,. User a ety Recommendations . I' Users should wash hands bolore eallng, drinking, chewIng gum, using tobacco or using tho loilot. 

R(lnlOV(l clolhi immediatel if Gsticide ots Inside. Thon wash Ihoro hand ut on clean clothln . 

14 

.; 
-~-----------

EtNIRONM~TAL HAZARDS _ Fprferroslrlal usos, 0 not apply dlrl.lCt/y 10 water, or to areas where 3Urlaco wafer Is present or 10 Intot1ldal aroas below tho mean high 

viMoU'll.arlCDO- contaminate wat&r whon disposing of oquipmoot ~ashwalors. 

Do not contamlnato wator usod lor Irrigation or domostlc purposos, 

USE PRECAUTIONS 

00 not apply PREpnI brond Ethophon through any Iypo of Irrigation "ystom. 

Avoid spray drift 10 ".arb)' crops as Ihls product will cause mooiUcalions In plant growth. Plant Injury Of reduced yields will (&sullo 

00 t\Ot plant anolhor crop within 30 days after troatment. 

Mix only tho amount 01 spray you oXp&d.lo uSe oach day. Do not allow mixed solution to stand ovornlght. 

DIRECTIONS FOR USE 

It 18 a viola lion of Fedetal law to u •• this product In a mannor Incon81stent with Its lab.llng. 

Road ontlr. labol balor. using fhl. product. 

Do nol apply Ihls product In a way that will conlact workers or other persons. olther directly or through drift. Only protocted handlers 

may be in tho area during aPPlication. For any roquiroments specilic to your State or Tribe. consult tho agency rosponsiblo for 

p&$tlcido regulations. 

'Use this product only In acoordatlce with Its labeling and with tho Walker Protection Startdard. 40 ern part 170. This standard 

lor the protection 01 agricultural wotkers on tarms, lorests, nurserios, and greenhouses, and handlers of i 

k contains requirements for training, dooontaminalion, notHicallon. and emergency assistance. It also 

and expectations pertaining to tho statements on thi" label about personal protective equipment 

restrictod-entry intervals. The requirements In this box only apply to usos 01 this product that are OO" ... ,iJ 

Standard. 

n01 onter or allow worker entry Into treated areas during the restricted-entry interval (REI) 0148 hours. 

for early ontry to treatod areas that is parmitted under the Worker Protection Standard and that Involves contact 

baen treated such as plants, soil or wator is coveralls over short-sleevod shirt and thort pants, watorprool 910"'.1 

tootwoar plus socks, protoctlvo eyewaar and chomlcal-rasl$tanl hoadgear lor o .... rhoad exposure. 

I I 

STORAGE 

')0 not contaminate water, tood, or tud by storago or disposal. 

I" container Is broken or contonts havo spiUod, lollow all precautions fndicatQd above and clean up Immediately. 80foro cleaning up, 

~ out on fuiliongth trousers, long sleevod shirt, protecUve glovos, and gogglos or lace shlold. Soak up spill with absorbent media such 

• 

1$ sand, oarth or oilior suitable material and dispose 01 waste al an approved waste disposallacility. 

PESTICIDE DISPOSAL 

"\ Posticlde wastos are acutoly hazardous. Improper disposal 01 GXCess pesticide, spray mixturo. or Iinsato Is a violation 01 Fedorallaw, 

H those wastos cannot be disposed of by use according 10 label instructions, contact your Stato Puticide or Environmental Control 

Agency or the Hazardous Wasta represenlative at the nearost EPA Regional OIl1co lor guidance. 

CONTAtNER DISPOSAL 

Triple rlnso (or equivalent) the ompty container!;. Thon oller lor rocycling or rocondklonlng, or puncture and dispose olin a sanitary 

IandtiR, or by Incineration or iI allowoo by stato and local authorllres, by burning. H containor Is hurned, stay out ot smok •. 

RETURNABLE - REFILLABLE CONTAfNERS 

Mat Ute, return tho containor to the point of purchase or designated locations, This contalnor must only bo rollflod wLtI] PflEpnI tnt"d , Ethaphon for Cotton and Tobacco. 00 NOT REUSE THE CONTAINER FOR ANY OTHER PURPOSE. Prior to roifll1ng, InipeCt 

thoroughly for damago such as cracks, punctures, abrasions and damaged or worn out threads on closure devicos.' Do not reflllJl1 

transport damaged or laaklng containers, Check for leaks aftor refilling and betore transportation. For Information on {he disposal''li 

unused, unwanlod product. contact Ahlln&--Poulenc at f·800-334-9745. For informaHon on cklanup of spills, contact RMrIEl·PoulCU1.P ~t 

t·800·334~7577. "tho contalnor Is not bel refillod rotorn it to tho int 01 urchaso. .~. ' • .1 ~ 

GENERAL INFORMATION 

COTToN 

A 10Har spray of PREpw brand Ethophon will acc$lorato 0p$ning 01 maturo unopened collOn bolls and onhanco doi(..l:aH~;; which c3n': 

rosult in oarlier horvest with an Increased r&COverablo yield. PREpni brand Ethophon treatm$nt on cotton allows incrlJascd etflclencY' 

Irom a onco-over harvaS!. • ." 

15 
TOBACCO (FLUE-CURED): A foliar spray 01 PREpllI brand Elhaphon promotos oarly, unllorm -yellowing* 01 maturo tobacco. 

PREpm roduc&s curing limo, aUowfng moro ollicionl use 01 curing barn spaco, 'and incrGasod control ovor halvost schodufos. 

SPRAY PREPARATION 

Add 112 to 314 of tho roquirod amount of wahH 10 tho spray lank. Slart agilalion. Add tho requirod amount of PAEPnI brand Elhephon, 

and tho remainIng amount of walor. Propam only as much spray sclullon as can bo usod on tho day 01 mixing. 00 nol allow spray 

1iOlution 10 stand ovornlght. Do not spilliho conconlralod product on $pray oquipment, Ot any airplano parbt. 

ANY SPillS SHOULD BE RINSED lMMEDIATEL V WITH PLENTY OF WATER 

Uso of a nurso lank Is highly recommondod lor avokling possiblo splfls of conconlt81ed formulation on $pray oqu1pmonl or any airplano 

parts. 

TANK MIXTURES WITH DEFOltANTS AND INSECTICIDES 

PREPn.: brand Elhephon Is compalible whh DEFt, FOLEX<II. Dropp2, Harvado3 , Molhyl Parathion, Gulhlon r, and Malathion". PAEpN 

may be applied In sequence or as a lank mixlure (DO NOT TANK MIX WITH DESICCANTS IF conON IS TO BE SPINDLE 

HARVESTED). Follow all appllcablo use precautions and ralo por aero recommondations on labels of products applied as tank mixlUros 

or 10 sequence with PREP 'IV brand Ethephon. In some cases slighl roduclion In boll oponlng responSG has boen observed when lank 

mixes with delolianls were usoo. 

Good agll:alion In Ihe spray tank is &ssonliaf and a lank mixture should nol be allowed 10 sland wjthoul agitation lor more than 5 10 10 

minutes. Read and obsorve all appropriale Iabol use dlrodions and procaullons lor th13 dafollanls and InsGdicldes used. . 

~ ~OTE: Under certain condttions, tank mixlures of PAEpN brand Elhephon with deslccanls containing sodium chlorate could 

result in Ihe lormallon of hypochlorous acids which on hoatlng will omilloxic chloride lumes. 

EQUIPMENT CLEANING 

• 

Because 01 the acidic nalure of Ihis product, prolonged exposure 10 spray deposH will damago acrylic plastiCS, certain painlS, and 

motals. 

• 

Rinsa lhoroughly with a dolorgonl and walor all oxposod acrylic plastlc·typo malerials (e.g" aircraft windshields), and palnled surfacos 

within .n hour alier exposure 10 spray deposlls. 

At the end of each day, rinse Ihoroughly with a delorgonl and waler allihe molal parts of Ihe aircraft and Iho assoclalod spray 

oquipmonl oxpos9d 10 Iho spray doposils< 

AOCI!!"fIjD 

_COM-~ 

la 11'/\ Utter Dt,."j: 

1 b,\~, l!"~ l'vL, ,! riY'llUlcWe 

.: .. ;." ;~'1.!i:': .,~ .. ",~:;.\::: '~.ct 

, f- " :: ,- t" l.-'k:,~e 

'."'" fer;,'::).:'::-: Nt}. 

J.(rdl--=:.-!.! ( R -

~~~ .~ .. ----------- 16 
I 

c6fi'l:iN 

EXPECTED PREP'!'\< ONE SPRAY VOLUME APPLICATION 

USE CONDITIONS RATE GALLON {Gal alA) TIMING 

~~HT":' 

PI, lDS A.!, A., •• AIr"" 

PREpm Hot and dry tWF or 11/3 1.0 6 Apply woon tho numb.r.f~ 

Boll Opener· higher matura unoponed bolls 

Dfy and 75 10 80°F 2 1.5 4 sullielent 10 produco -~~~~ 15 -SO 2·5 desired crop, Soo below 

Cool but abo ... " 65<;F 2213 2.0 3 1051 of boll m~;~IX~ Treatmont uniformly 

R.nk en,'::n 

bolls 710 14 days oarfier. 

PREprw + High soil moisture ,/3 0.25 2' 15 - 50 5 -10 

FOLEX* Apply 4 10 7 da:0r.E;~ 0' PAEpTW. boll 

"elollan( Tank High IArtility lovol application. To bo ~_~s 

MIx 0' a ~~U;I= troaJmon£w~~ ! Rank coNon 

nol I I of PAEprn 

Dropp2 High soU moisluro 113 0.25 2' 10 - 50 3 -10 I App~ 4 10 7 day. "'~~~~ Defoliant Tank High 10rtUity lovol boll openl 

MIx Rank cotton . To bous.ad. as 

, a' ~i~,,~,~.trGa'mOnl with, I not - of PREpni boll 

I 

Pr.-Condltlon.r Hot, dry. abovo 80QF 2/3 0.5 12 Appty 4 to 7 days prior to 

10' Oefollatlon Cool, above 65~F 11/3 1.0 6 15·50 2-5 deloliant. Enhances top 

0' crop defoliation r.d~;'; deterioration of bottom 

Rank colton and allows lor 

·Pretreatment With Defoliants PrIor to PREpn.! Boll OpenIng Trealment 

H tho colton Is overly rank or laying down In tho mlddlea and good spray coverage of tha bolls whh PAEpl'U Is difficult. a protrealmont 

with dafollants will bo uselul to improve boU coverage with PREpni. Use do$age ratos 01 PREpni brand Elhophon recommended lor boll 

)poning. Road and observe all appropriate label use dlroctions andprocautions lor tho dofoliant us&d. 

"In Ca~fomia and Arizona use a volume 01 no leM than 5 gallons per acre for aorial applications . 

• 

- '9011 Maturity 

A bon Is malure when it Is too hard 10 btl dented \\!hen SQuoozad botwoen thumb and lingers. too hard 10 bo sliced wl1h a sharp knifo, and 

when tho seed coal becomes lighl brown in color. 

Use lImllatJons 

Do not eXCGOd a maximum 01 2.0 lb. altA forcombinod USGS of PAEpnt por acro par yoar. 

Boll OpGning: Do noltank mix PREpl'U brand Etlwphon whh a doslccant if tho cotton is to btl spindle harvosted. 

Pre-Condition lor Defoliation: Do not tank mix PREpm with desiccants vnlDss plant dosiccation Is requlrod. Do not use a defoliant 

boloro thoro Is suHiciont matum unopenod bolls to produce the dosired yield (seo Genorallnlormatlon section on how to lost for boll 

maturity. 

WHEN TO HARVEST COTTON 

Do not harvost cotton sooner than 7 days alter a troatment with PREpnt brand ElhOphon. ...... 

Observe tho treatod crop and harvost whon optimum OOllop&ning ha!!. boon reached. Too oarly harv&$t mighl reduce the}uU advantaiJ:l 

of the trea/mont and too late a harvost may result in reduced qualily and Ios5 of lint which will drop lrom 1he plant. . . ' 

17 
... - - ---.. --- --------------

Crop 

DIrected Spray 

Application 

Applicalion 

PREplloI 

Pinto/Aero 

1 1/3 

1 113- 2 2J3 

USE LIMITATIONS 

SO-50 

40-60 

TOBACCO 

(Flue-Cured Only) 

Spoclflc Directions 

Use drop nozztes. Chooso TG or OC spray lips designed to apply 50 

gpa al 35·40 psi and at traclor speed 01 2·3 mph. 

2 tho noulel spray PGf to tho row; loa.vas one on to oach be side ripened 01 tho and rowdroppod haN.sled. ~':!~:~~~:::!i:: I 

is Qssonttal. WlIh a directed spray, be sur. to harvosl 

Troat only whon leaves remaining on tho stalk: are 

remaining loavos ar. mature, lost spray soveral 

doscribed under tho $oCllon ·Proper limo of Treatment, 

In a normally malUfO crop whon o)(porionce Indicates thai 

tnducomonlls required. Usolho higher ralo whon Iha _··c- .:'C .. ' 

a londoncy to be more rank or whon temperaturos are ~~:;:;;~~ I 

Always lost spray 10 deformlno if tho tobacco is maturo o""",h " 

10 Ifoalmenl whh PREpm brand Elhophon, 

Apply ovor*lho-lop PAEptl.l brand Elhophon spray as a fino mist using 

oozztos (ono nozzle lips ovor tho centor of tho plant, and one on each 

so an leaves are coyorod , slmhar to tho 

I I 

Do nol apply PAEPm brand Elhephon to Imrnaluro laaY05 as this can rosullin unsallslactory coloring, welghl loss and reduced leal 

qualily. 

00 nol allow tho Cfop to ovor ripon In tho fiold allor using PREP"" brand Elhophon, sinco this may cause some roduction In yield and 

quality. 

Do ooltreol bofofl) onlicipaled major storm which could pl'ovanl harvesl and result In crop loss. 

Do nol apply PAEp1lI brand Elhophon if ratn is oXPOClod within 4 hourn:. 

APPLtCATION TIMING 

SlJCCOssfut results with PAEP~ can for Iraalmonl whon loa'.'o$ are moMe, nol ovorly rank groon whon sprayod. To easily dolarmino 

th. proper trealmentliming and tho numbor 01 loaves per stalk roady for harvost, tesl spray $evoral plants In more than ono location In 

each Hold and obssrvotho rosponso, Maturo loavo$ wlh begin to yellow In 241072 hours. Tesl loavssthllt fail to yollow In 72 hours are 

\Ot mature and are not roady lor PREP"" brand Ethephon trsalmon!. Wait a fow days to permit furlher natural maturing, then mako 

another tosl spray or -malurity- chock, 

- When you have confirmod Iho numbar oll4av(Js por plamthat will color, you can dOlormlno tho numbar 01 aCr8! 10 Ireat In order to IIH 

•

• hebarn, 

Propar8 your lost spray by mixing OnG te-aspoon 01 PAEpllA In I quart 01 wator. Spray oach tost plant with aboul I oz. 01 this mixluro, 

covoring oll laavo& with a fine mist. PREprM brand Elhaphon wllt not colo! immaluro sprayod loavo!t 

WHEN TO HARVEST 

AU maturo, sprayed loaves will bogtn 10 color wimin 24 10 72 hours aftor PAEpl1.I brand Ethophon appHcaUon. Tho yellowing procoss 15 

wootherdependont: cool woather wUl dolay. while hot, sunny weathorcan spooo up tho process, Harvosltroated lobacco whon loavo$ 

have reached the dosired color intonsity. 

Do not allow tobacco to becomo ovor ripe boloro starling haMSI. Leaf drop can occur when tobacco Is ovor ripe and lolt on the stalk. 

H a number 01 tho bottom loaves havo yotlowod at tho limo of tr8atmont, !hoy should be harvostod prior to spraying with PflEpm brand 

Ethophon. 

Wilh an ovoHho·top applicalion. harvosling can commonco 24 hours altor PREpm brand Ethophon application depoorlln') on Wojiihor : 

con(mions or to avoid over ripo toboo:o, Tobacco harvested 24 hours rotor trealment wilt require more limo In tho co:Oring f.1hase (A tho • 

curing procoss. 

CURING PREpw TREATED TOBACCO 

Curing procedule5 are as much an art as a science and aach cure must be judg&d on tho basis ollobacco CClndition, irllGNaI btJtwii~h' • 

treatmenl and harvssl, woather and type 01 curing facility before prescripllon lemperalure and ventilation ,:.chtldules can' hijeslabllshed. To obtain maximum quanty, cara must bo laken to observe and CClntrol tho curing process closely, es'pe<:ialtf during th-a 

late -coloring- and early -drying" stagos of Iho loaf. ••••• : 

PAEpm brand Ethephon troatod lobacco witt have started Iho coloring procoS$ when harvosted, rooucing the tlmo rO!:juirod In Ihe •• 

coloring phase 01 curing. Trealod tobacco should be dried laster. If tobacco leavos aro groon or conlain somo greon' lV'1grtnarvostM: ~: 

It may be nacossary to color them for a few hours. If tho loavos are completely yellow, lemperature and ventitation musl oo,adjuSlbd iff' 

a manner 10 dry tho tobacco as last as possible whhout scalding, Once the Ioat Is dried (3/4 dry), you should foRow ('IQrD'faJjlrocedures 

lor curing. Sinco PREpnr brand Ethephon treatoo loaves cure faster, lrealed and untreated loavos should oot bo cured togethor In tho 

samo barn, 

18 

J , 
~-~---------

LIMITED WARRANTY AND DISCLAIMER 

Tho mantlfaClul0r warrants (8) thai this product conforms to tho chomJcll1 description on tho labol; (b) thallhls product Is 10asonably lit 

for tho purposos sol forth In tho dlroctions /01 us. whon It is usod In accordance with such dlroctlons; and (c) thai tho directions, 

warning and othor statemonts on this labol 8ro based upon rosponslblo exports' evaluation 01 roasonablo tesla of offoCi1'lonoss, of 

toxicity to laboratory animals and to plants. and of rosldues on food crops and upon roports of f10ld OXp61h)OOO, Tosls have nol boon 

mado on alt varieties Of in all states or under aft conditions. THE MANUFACTURER NEITI-IER MAKES NOR INTENDS, NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES. EXPRESS OR IMPLIED. AND IT 

EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANTIES OF MERCHANT-ABILITY OR FITNESS FCR A PARTICULAR 

PURPOSE. 

THIS WARRANTY DOES NOT EXTEND TO. AND TIlE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND All LOSS OR 

DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHKiH IS INCONSISTENT WITH mE LABEL 

DIRECTIONS. WARNINGS OR CAUTIONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SEllER'S EXCLUSIVE LlABlLlTY FOR ANY AND AU CLAIMS. 

lOSSES, DAMAGES, OR INJURIES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT. WHETHER OR NOT BASED IN 

CONTRACT. NEGLIGENCE. STRICT LIABILITY IN TORT OR OTHERWISE SHAll BE LIMITED. AT THE MANUFACTIUREA'S OPTION. 

TC REPLACEMENT OF. OR TIlE REPAYMENT OF THE PURCHASE PRICE FOR. THE QUANTITY OF PRODUCT WITH RESPECTTO 

WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHAlL MANUFACTIURER OR SELLER BE LIABLE FOR SPECIAL. INDIRECT OR 

CONSEQUENTIAL DAMAGES RESULTING FADM THE USE OR HANDLING OF THIS PRODUCT. 

10TICE TO BUYER 

rurchasa of this product dOGS not confer any rights under palionts governing Ihis product or tho use therool In countrios oUisklo 01 the 

Unltod States. 

e rDEF and Guthion ilro rC9lstorod tradomarks of Bayor AG, Gurmany. 

2Dropp Is a rogistorod trademark at NOR·AM Chemical Company. 

3Hruvade is a registoroo tradomalk 01 Uniroyal Company. 

• 

4Malathion Is a trademruk o! Amoran Cyanamid Company . 

RhOne-Pouleoc Ag Company 

P.O. Box 12014, 2 T.W. Alexandor Drivo 

Rosoarch Trianglta Park, North Carolina 2n09 

PREP Is tho trademark 01 Rh6ne·Poulonc. 

FOlEX Is a registered trademark of Rhllno·Poulenc . 

PREpm brand Ethophon lor Colton and Tobacco (PENDING) Submkt&d 10/t5l93. 

. ..... 

19 
ETHEPHON FOR COTTON AND TOBACCO 

For Commercial Use Or Agricultural Use Only. Not For Residential Use 

ACTIVE INGREDIENT: Ethephon (2..chloroethyJ) phosphonic acid· H ...................................................... 55.4% 

INERT INGREDIENTS: ........................................................................................................................... 44.6% 

-This product contains 6 pounds elheehon per gallon. 

EPA Reg. No. 264-418 EPA Est. No. 264·PA·Dl 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

Sf uslod no &nilondo Ja .Ik· luola, b~"1u. ,~~tg~i<," p"aquo 

t ~~~~~~~~~,- For PRODUQI u.ss Information Call 1·800·334·9745 

• he use 01 this product for a varioty of plant growth rGguJaUon USGS are protectod by Unitod Stales and loroign palonls Including 

U,S, Patents 38,791. fsa and 4,240,819. No Jic&nse is granted to use this product In counlnGs other than the United Stales or lor any 

use not contemplalad by this label. UabWty lor pah:mt inJrmg&m~mt may rasuk from usa or salo of this product outside the Unlted 

States • 

• STATEMENT OF PRACTICAL TREATMENT 

tF tN EYES: Hold eyelids opon and Hush with a gontlo stream 01 wator lor atlea5115 minutes. Get medical attention, prolerably an 

ophthalmologIst. 

tF ON SKJN: lmmodlatety wash skin with p!onty of soap and wetor. 

IF SWALLOWED: Do not Induce vomiting. Promptly drink a large quantity 01 milk, egg whllO$. gelatin sotution or Itthoso are not 

avaiJabIG. drink largo quantitios 01 water. Avoid alcohol. Call a physIcian immediately. 

IF INHALED: Remove victim to tr9sh air. Jt not breathIng, glvo artillclat respiration. Adminisler oxygen if nGCGssary. Got modlcal 

attention. 

PRECAUTIONARY STATEMENTS 

DANGER 

:iAZARDS TO HUMANS AND DOMESTIC ANIMALS 

CORROSIVE. Causos oyo and skln dam ago. May b& fatal if ablSotbOd through skin. Harmtul it swallowlKf or inhaled. AvoId breathing 

lp!ay mist. Do 001 got In eyes, on skin or on clothing, Keop away trom domestic anImals. 

nOTE TO PHYStCIAN tI .. There is no specific antldote. All troatment should b& basod on obselVed signs and symptoms 01 distress in tho patlent. Qvaraxposuro 

".,.." to materials other than 1hfs product may hava occurrod. 

Victims of sovere overexposure. by Inhalation, should b& kopt under medical obsolVaUon tor up to 72 hours tor delayed onsol 01 

pulmonary edema. In a victim 01 over·exposure by Ingostion, careful gastric lavage Is required due to the possIbility of stomach or 

esophageal p&r!oration. This matertatis an acid, but uso of alkaline substances to neutralize it is contraindicated. 

PERSONAL PROTECTIVE EQUIPMENT (PPE) 

Applicators and othor handlers must wear coveralls ove.r short-sleeved shirts and short pants, waterproot ~Ioves, .::f1~.rr:.~I-resistant 

footwoor plus socks, protective oyowear, chomlcal-rosutant hoadgoa.r tor overhead exposure and chemIC8.1·res~stant apron when 

cleanIng euipmonl. ,. ~. ~ • - ; •. : 

Dtscard clolhing and other absorbOO matorials thet have bun drenchod or heavily contaminaled with Ihis product;'(X"l~ntratee OQ • 

not reuse them. Farlow manulacturer's InstrucHons for cleanlngfmaintaining PPE. If no such inslructions lor washabl&s:use dete~tnt·: 

and hot walor. Koop and wash PPE soparalely from other la.undry. '. •• 

When handlers use closed systems, onclosed cabs, or aircralt In a manner Ihat moets the requirements listed In th6~W~;ko·r Prot;dl;'~~ -

Standard (WPS) lor agricultural pesllcides 140 CFR f70.240 (d) (4-6)}, the handlor PPE requiromonts may bo rodll!»d'ol' ;nodiJiod a; 

spocifiod In tho WPS. 

User Safety Recommendations 

Users should wash hands beloro eating, drinking, chowing gum, using tobacco or using the tolkll. 

Remove clolhl immediate if slicide ots Insido. Thon wash thorou hand ut on dean clothin 

20 
- -- ---- ~~~-

ENVIRQ NTAL HAZARDS - Fp(fettOSlrlal USGS, nol apply directly to water, or to aroas whore surface wator Is present or to Intertidal areas bolow tho moan high 

w1rtor.mruICOO (fo contaminato Walar whon disposing 01 equipment washwalots. 

Do nol conlamlnalo walor usod for Irrigation or domosllc purposos, 

USE PRECAUTIONS 

Do not applv PAEprv brand Ethophon through any typo of irrigation system. 

Avoid spray drifllo nearby crops as this product wiD causo modifications In plant growth. PlanllnJury or reduced yields will result. 

Do not plant Gnother crop within 30 days after tIoatmonl. 

Mix only tho amount of spray you oxpBCt 10 U$O each day. 00 not allow mixod solullon 10 stand ovornlght. 

DIRECTIONS FOR USE 

It Is a violation of Fed.ral law to us. this product In a manner Incon81stent with Its taballng. 

Read entlr. lab.1 before using thl. product. 

Do nol apply this product in a way that will contact workers or other porsons, either directly or through drift. Only protected handlers 

may be In the area during application. For any requirements specific to your State or Tribe, oonsu~ the agency rosponsiblo lor 

pesticide rogulatlons. 

for tho protection 01 agriculturat workers on farms. lorosts, nurserlos. and luse this produd only In acoordance with Itslabaling and with tho Worker Protoction St~nd~'l'd~'~4~O~r~~~~~~~~:~~~~~~~1 It contains reqUIrements for training. docontamlnation. notiticatlon. and 

and expectaUons pertaining to tho statements on this labol about parsonal 

and restricted-entry intervals. The raquiromonts in this box only apply to uses 01 

Standard. 

(lOt ontor or allow worker entry into treated areas during the restricted-entry interval (REI) 01 48 hours. 

r&<lulred lor ontry areas that is porm~ted under the Worker Protection Standard and that involves contact 

that hu as piants. soil or wator is coveralls ovor short·sleelloo shirt and short pants, waterproof g~,".", 

socks, protectlve,oyewoar and ch~micaf.res/stant headgear for overhead exposure, 

not contamlnato water, food, or teed by storage or disposal. 

III container is broken or contents have spilled, follow all pr~autions indicated abovo and cloan up immodlatoly. Bolore cl"ao',,,, - out on fuU kmgth trousers, long steoved shirt, prot.mive gloV08, and 909gl8$ or face shleld_ Soak up spill with absorbent 

rs sand, earth or other suitable material and dispose of waste at an approved waste disposal facility. 

DISPOSAL 

1P"~~lk;id" wastes are acutely hazatdous. Impropor disposal 01 oxcess pesticide, spray mixture, or rinnte is a violation 01 Fodera! 

Ihese wastes cannot be disposed 01 by use according to label instructions. contact your State Pesticide or Environmental CoO'""1 1~~~:i..;OI'~":h~G Hazardous Waste roprosontativo at tho nearest EPA RGglonat Offica forguidanco. 

It DtSPOSAL 

rinso (or oquivalent) tho empty containers. Than oller lor rocycting or roconditioning, or puncturo and dispose 01 in a ,."h,oyl I or by inclnoratlon or If allowed by stato and local authorities, by burning. -H container Is burned. stay out 01 smoke. 

RETURNABLE •• REFILLABLE CONTAINERS 

US., return the container to the point of purchuo or deslgnatod tocations. This contalnor must only be refilled wttf1.P~EPn.( 

for and Tobacco. DO NOT REUSE THE CONTAINER FOR ANY OTHER PURPOSE. PriOr t:l reflWng, 

for such as cracks, punctures, abrasions and damaged or worn out threads on closure devlcos.· 

containers. Chock for ronks after rofilling and bofore transportation. For Information 

RhOne·PoulGnc 1-800-334-9745. For Information on cleanup of apHis, 

I 

GENERAL INFORMATION 

COTTON 

• 

• 

A foliar spray 01 PREpw brand Ethephon will accelerate opening 01 mature unopenud cotton bolls and Gnhance dei<.J:a:bii which C3n' : 

result In earlier haMst with an mcreased recoverable yiokL PAEpnf brand Ethophon troatment on cotton allows Increased olficl'oocY' 

lrom a onco-over harvosl. • ". 

21 
TOBACCO (FlUE·CURED): A foliar spray 01 PAEpru brand Ethephon promotes andy. uniform "yollowing" 01 maturo tobacco, 

PREpm foducas curing timo, allowing mora officionl USG 01 curing barn spaco, and Increasod control ovor harvesl schodulos, 

SPRAY PREPARATION 

Add 11210314 of tho required amount of waler 10 tho spray tank. Start agkalion. Add tho required amount of PREpN brand Ethophon, 

and tho romaining amount of water. Prepare only as much spray solution as clln be usod on tho day 01 mixing. 00 not allow spray 

solullon 10 stand overnight. Do nol spliliho concantratod product on spray oquipmonl. Of any airplane parts. 

ANY SPUS SHOULD BE RINSED IMMEDIATELY WITH PLENlY OF WATER 

Use of a nurse tank Is highly recommended for avoiding possiblo splits of concentrated formulatton on spray oqulpmanl or any airplane 

parts. 

TANK MIXTURES WITH DEFOLIANTS AND INSECTICIDES 

PREpm brand Ethephon Is compatible with DEFt, FOLEX~. Dr0pp2, HalVada3 , Methyl Parathion, Guthion t , and Malathion", PREP'Ilj 

may be applied In sequence or as a tank mixture (DO NOT TANK MIX WITH DESICCANTS IF COTION IS TO BE SPINDLE 

HARVESTED). Foliow att applicable use precautions and rato por aere rocommondatlons on labels of products awUod as lank mixtures 

or in saquence with PREP T!.I: brand Ethephon. In some casos sllghl roduction in bolt oponlng response has baen observed when tank 

mixes with defoliants were us&d. 

Good agitation in Ihe spray tank is essential and a tank mixture should not be allowed to stand without agitation for more than 5to 10 

minutes. Read and observe all appropriate labol use directions atJd precautions for tho defolianls and ins:ecticidos used. 

t{OTE: Und&r cortsln conditions, tank mixtures of PREP""' brand Ethephon with desiccants containing sodium chlorate could 

result In Ihe lormation of hypochlorous acid$ which on heating wltl emit toxic chloride lumes. 

EQUIPMENT CLEANING 

Because of tho acidic naturo 01 this product, prolonged exposure to spray deposit will damage acrylic plasticS, cenaln paints. and t 

metals . 

• Rinse thoroughly with a detergent and water all oxposod acrylic ptastic·type materials (e.g., aircraft windshields), and painted surfaces 

wtlhln an hour after IIxposuna to spray deposits, 

At the end ot each day. rinse thoroughly with a dotorgent and wator all tho motal parfs of tho aircraft and the associatod spray 

oquipmont oxposed to tho spray doposils, 

A(X:ll1;"fliD 

_COM~'f$ 

1a IPA lcu;~r Dtled~ 

J 0 iJ ...:.:..-!L/ wl/C'----__ 

22 
I 

COTTON 

EXPECTED PREp'll< ONE SPRAY VOLUME APPLICATION 

USE CONDITIONS RATE GALLON (GalafA) TIMING 

PREpm 

PlnlaiA I~~s A,I, Acro. Air" 

PREptu Hot and dry SO>F 01' I 113 1.0 6 ApplV when tho number of 

8011 Oponor* higher malure unoponod bolls [s 

DIY and 75 to SO'F 2 1,5 4 IS ·50 2·5 

sufficlont to produce tho 

doslr&d crop. See below for 

I Cool but above nsoF 22/3 2.0 3 tost of boll maturltv. 

Troatment unilorm1v opons 

or bolls 710 14 days oarll.r. I Rank COllon 

PREpn.! + High soil moisture 113 0.25 2' lS· 50 5 ·10 Apply • 10 7 days p'lo~ 10 

FOLEX$ or P!1_~PN boll I 

...... foll.nl Tank High lar1l1ity loyol . To "'.u~"!h~ illx 0' ' ~~II~ pl~~I~t"~~E·~' boti 

I Rank cotton , 

PREPt'IoI+ -' High soil moisture 113 0,25 2' 10-50 3 ·10 Apply 4 to 7 days prior 10 

Tank High fertility levol PREp'lV boll op~ning 

To be uud an 'Mix Rank colton ~._ Iraalmont with, 

nOlln pl~_.ol PREpm boll 

Pr.·Condltlonot Hot, dry. above BoeF 213 0.5 12 Apply 4 to 7 days prior to 

for O.folhltlon Cool, aboyo SS"F 1113 1.0 6 t5-50 2·5 dofoliant. Enhances-_~~~ 

or crop defoliation roducing 

deterioration 01 bottom crop 

Rank colton .nd allows 10' earllor 

·Protreatment Wl1h Oefollants Prior to PREprn Boll Opening Treatment 

If tho COlton Is oyorly rank or laying down in Iho mlddlo. and good spray covorage oltha bolls with PREpTW Is djl1icu~, a prelroatment 

with dololiants will be usolul to Improve boll covorago wkh PAEPnt. Uso do$age rates of PREprn brand Ethephon rocornmandod lor boll 

1pGning. Road and obsorve aU appropriate labol use direclions and precaulions for tho dofollant used. 

Hln California and Arizona usa a volume 01 no less than 5 gallens pet aere fot aorial applicallons. 

'ioll Mafurlty 

A boll Is mature whon it is foo hard 10 be donled whon squoezed between thumb and fingers, too hard to be sHced wllh a sharp knifa, and 

.tWhen the seed coat bocomes light brown in color. 

Use Limitations 

00 not oxcaod a maximum of 2.0 lb. aliA forcomblnod uses 01 PREP'" per aero por year. 

Boll Opening: Do not tank mix PREptlol brand Elhophon with a desiccant if Ihe cotton is to be spindle harvesled. 

Pro-Conclilion for Oeloll8tlon: Do not tank mix PREp-rtI with dosiccants unless plant desiccation is requir&d. Do not use 8 dafoliant 

befora thoro is sulficient mature unoponod bolls to produce tha desired yreld (soo Ganerallnformation section on how to tosllor boil 

maturity. 

WHEN TO HARVEST COTTON 

Do not harvest cotton soonor than 7 days aftar a treatmont with PREPN brand Ethophoo. 

ObsOI'YO tho traalGd crop and harvest whon optimum boll opening has boon roached. Teo oarly harvest might reduco th~fuH adY8nta.J.» 

01 tho ttoatment and too lato a harvest may rosultln rooucoc:l quality and loss 01 lint which will drop from tho plant. , 

23 
I 

---------------------

PREprn 

Crop Sfluallon Plnta/Acr. 

A ... 

Oirsctod Spray t tl3 50- 60 

Application 

Over-Tho-Top 1113-22/J 40-60 

AppUcalion 

USE LIMITATIONS 

TOBACCO 

(Flue-Cured Only) 

Spocl!lc DIrac lion. 

Us. drop nozzlos, Choose TG or DC spray lips designed to apply 50 • 60 

gpa at 35·40 psi and al tractor spoed of 2-3 mph. Us. 

2 nozzles por row; one on each sldo of tho row dropped low enough 10 dll"$cl 

tho spray to the loaves to bo riponod and hafVested. Thorough spray 

Is .ssentiat With a diroctod spray. bo sure 10 harvesl aU loaves 

IWHh20%o< ; . 

Treal only when leaves remaining on Iho stalk afe maturo. To onsure 

romainlng loaves are malur., losl spray sevoral tobacco plants as 

doscribed undorlhe $ocllon ·Propor TIme 01 Treatment." Use tho lower rale 

in a normally mature crop whon experienco indical" thai minimum ripening 

inducemont is required. Use the higher rato when tho crop Is heavy and hll$ 

a tendency to be more rank or whon temperatures aro lowor than normal. 

Always losl spray 10 dotormino iI tho tobacco Is mature enough to respond 

to treatmanl with PREprw brand Ethephon. 

Apply over-the-top PREpn.I brand Ethephon spray aG a fino mfsl using throe 

nozzles (ono noule tips over the center 01 the plant, and 0110 ~~l~~e~~O) 

so all loaves ~;~~~~[ed similar 10 the) Of!O to of ,I aa.nl~ ~ sorav 

Do not apply PREP~ brand Ethephon 10 ImmelUro loaves as lhis can rosuh In unsatislactoty coloring, woightloss and reduced loaf 

quality. 

00 not allow the crop to over ripon in tho lield rutor using PREpTloI brand Ethophon. sinco this may cause some reduction In yield and 

quality. 

Do nottraat balore antlcipatod major storm which could ptavont harvast and resu~ in crop loss. 

o 00 not apply PREfn'4 brand Ethophon if rain Is expectod within 4 hours. 

APPLfCA nON TIMING 

Succosswl resulls with PREpTloi call lor Iroalment whon leaves aro maluro, not ovorly rank groan whon sprayod. To easily dotarmlne 

tho proper traatmanttiming and Iho numbsr of leavos por stalk ready lor harvest, tast spray several planls In more than ono location In 

oach liold and obsefVothe response. Mature loaves will begin to yollow in 24 to 72 hours. Test Ioavas that faU to yoUow In 12 hours are 

lot mature and are not raady lor PREpN brand Ethophon treatment. Wait a low days to parmillurthor natural maturing, thon make 

anolher losl spray or "maturity" check. v -, Whan you havo confirmod the numbor 01 leaves par plant that will color, you can dalermlno the numbor of acros 10 lroalln ordor to 1m 

.he barn, 

Prapare your tasl spray by mixing one teaspoon of PREpnl In t quart 01 Wator, Spray oach tost plant with about t oz, 01 this mixture, 

• covering slil&avas with a fino mist. PREfn'4 brand Ethophon will not color Immature sprayed leaves. 

WHEN TO HARVEST 

All mature, sprayed loaves will bogin to color within 24 to 72 hours alter PREpN brand Ethaphon application. Tho yellowing process Is 

weather dBpGndenti cool wealhor will dolay, wllUG hot, sunny weather can speod up th& procass. Harvost troatod lobacco when Ieavos 

have reached tho doslred color Intenslly, 

Do not allow tobacco to oocoma ovsr ripe bolof(~ starting harvest leal drop can occur when tobacco Is OVer ripe and loll on the slalk, 

If a number altho bottom loavos have yeliowod altho time ollrealment, Ihey should be harvosted prior to spraying 'lfith PftEpn.! brand 

Ethaphon, 

Wllh an over·the-top application, harvesting can commenco 24 hours wter PAEpn.I brand Etllephon application deptll'lrlh,'J on wO\!lihq;' : 

conditions or to avoid ovar rlp&tobacco. Tobacco harvest ad 24 hours aher trealmenl will requiro maro time In tho co;orlnq phase ("f Ihe • 

curmg process, • ~ •••• 

CURING PREpm TREATED TOBACCO 

Curing procedures are as much an art as a science and each curo must be judged on the bas!s oltobncco condkion, ImerVal boIWei,th' • 

Ireatment and harvest, weather and type 01 curing lacility bolore proscrlpllon temperature and venlilation IIchE'dulo$ can' bi)" 

established. To oblaln maximum qualily, care must be laken 10 obsorve and conlrallhe curing process closely, especlalf; during tha 

lalo ·colorlng- and oarly "drying- slages 01 tho !eaf. • " •• , • 

PREP~ brand Ethaphon traatod tobacco will hava started tho coloring procoss whon harvested, reducing the tima rO::lulroo In the 

coloring phase 01 curing. Trealed toboo:;o should be dried fast or, If tobacco loaves are graan or contain some graen l.y'wfbarveStlid; .: 

it may be nacassary to coler thom for a tow hours, litho loaves are completely YGlIow, temperature and ventilation must be.adJusIGd iff' 

a mannor to dry tho lobacco as last as possible wkhout scalding. Once tho loal is dried (3/4 dry), you should follow (!QI'Dla./Procoduros 

for curlng. Since PREpm brand Ethophon troated Ioavos curo faster, troatoo and untraated !Goave!; should nol be cured together In tho 

sam. barn, 

24 
• 

-------------------

LIMITED WARRANTY AND DISCLAIMER 

The rnMulacturor warranls (a) that this product conlorms to tha chemical description on tho lab<.ll; (b) that this product Is reasonably Ik 

for the purposos sot fonh in tho directions for use whon it Is usod in accordance with such diroctlons; and (e) thai the dir&Ctions, 

warning and other statements on this label are based upon responsiblo experts' ovaluatlon of roasonablo tesls of effectiven"'ss. 01 

taxlchy 10 laboratory animals and 10 plants. and 01 residues on food crops and upon reports oillo/d oxporlonc4. Tests have not boon 

made on an varieties or In all states or undor all conditions. THE MANUFACTURER NEITHER MAKES NOR INTENDS, NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTAnVE TO MAKE, ANY OTHER WARRANTIES, EXPRESS OR IMPLIED, AND IT 

EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANnES OF MERCHANT·ABILITYOR FflNESS FOR A PARTICULAR 

PURPOSE 

THiS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHAlL BE SOLELY RESPONSIBLE FOR. ANY AND All lOSS OR 

DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHJCH IS INCONSISTENT WITH THE LABEL 

DIREClIDNS. WARNINGS OR CAUTIONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, 

LOSSES, DAMAGES, OR INJURIES RESUl TIOO FROM THE USE OR HANDLING OF THlS PRODUCT, WHETHER OR NOT BASED IN 

CONTRACT, NEGLIGENCE, STAICT LIABILITY IN TORT OR OTHERWISE SHALL BE LIMITED, ATTHE MANUFACTURER'S OPTION, 

TO REPLACEMENT OF, OR THE REPAYMENT OF THE PURCHASE PRICE FOR, THE OUANnTY OF PRODUCT WITH RESPECT TO 

WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, INDIRECT OR 

CONSEQUENTIAL DAMAGES RESULTING FROM THE USE DR HANDLING OFTHIS PRODUCT. 

tOnCE TO BUYER 

,-Iurchaso of this product does not canlor any rigllts undor pationts govornlng this product or tho use thereof In CQUntnos outside 01 the 

Unltod Slalas. 

e 1DEF and GUlhlon are rogl$lorod tradomarks 01 Bayer AG, Germany. 

2Dropp is a rogistorad froo&mark of NOR·AM Chemical Company. 

3Hruvado is a reglstored tradomark 01 Uniroyal Company. 

• 

~Malalhlon is a tradomark of American Cyanamid Company . 

Rh6no·PoulollC Ag Company 

P.O. Box 12014. 2 T.W. Alexander Drive 

Rosearch Ttianglo Park, North CaroNna. 27709 

PREP Is Iho trademark 01 AhOne·Poulanc. 

FOLEX Is a rogistorod tradomark 01 RhOne-Poulone . 

PREplW brand Elhophon for Collon and Tobacco (PENDING) Submit16d 10/15/93. 

25 
-----------------

.?Jian rnd"n.troctlon$ on rov.uo ,""". . nURNn '.30·" 

(Al Reglstrallon jOPPi , 

&EPA Officoof , e::-

Washington. DC 20460 I- Amendment 

Application lor Pesticide: Other 196579 

~ 

It. Mi~~n -"-;0 / ;,~;;c 3. "CEPA2;;""t 

WNOI1O o ReMdctoo 4. ComponylF'roduct (Name) ,PM' 

Micro Flo I 8THEPHON 6 22 

~ Applicant (If)(;/udo ZIP Coda) 6. . 'n ,wkh F'FRA S,Clion 3(c1l31 

Micro Flo Co. (b}{i). my product is similar or Idonlical in COfltposilion and labaling 

to: P.O. Box 5948 BREI! 

Lakeland! FL 33807 EPA Rag. No. 264-418 

o Chock if this is a now address Ptoduct M" ..... PREP 

I 

- Explain below Final p!intod Jabals 

~ I- Agoncy kino! 

-= 

in IOSponSO to Agoncy lo00r datOd _______ 

? '1.10 Too' Application. 

, - Explain below. 

Other· oxplnin oolow. 

Expfanallon: Uso additional pagels) it nQoossary. (For s&Cllon I and Section II ) 

Initial application for ETH8PHON 6 end use product. 

, III It. , , , , I Un, "" W .. " So""' 12 ~i Byos' rYes r- Yos J ... , 

~ No t --2L P',,,,, 

No No _ Glass 

lOY .. : No. pur 

~~~:~W9L No. per. f.-- Papcr 

, • CqrlffJcalkm musl bo w,l cOlllainor cootainor '-- OthOl" 

I 

li-- Net COtlrontsln/OfJ1llJlion 14_ 511:&(5) o\llelail , 5ao,' O'.l~b" i 

o lab" fX1 -- 1 2.5 gl , "od,~' 

I'M",,,, " VIh<" La"""""" ex , D Othell - -.I 

rt.-~pOinl 

~ ~. Tolophono No. I , MorTis Gaskins of Registrations (813)647"_3<308 --

I' 

t amity Ihtlilho statements I hal/o made on this lorm and all attachmonts ihorolo mo true, accuratB lIfld romp!"'\"}, . , I acknowledge thai any knowingly lalso or misleading s!awmenl may bo ponishablo by lino Of imprisonmont or ' - !~I!'!f1ped) both IJfIdor applicable law. - . --- -- . 2. 

-Jv;~ 3. TiO, . 

t fi../. "' '" of Registrations - -- ., -~~~. - -

~~Ga$kinS ,. D,,, ~~ .. -- February 1, 1994 

,PA Fom 8570· (R",. " ... ) .. " Whil. . EPA FU, Copy , Y,lIow 
• 

• 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON. D.C. 20460 

MEMORANDUM 

SUBJECI': Similarity ainie Determination for EPA 

FROM: 

Reg. No. / File Symbol: 51036-ERI / Etheplwn 6 

Ian Blackwell, Biologist 

Precautionary Review Section 

Registration Support Branch 

Registration Division (7505W) 

TO: Cynthia Giles-Parker, PM 22 

Fungicide-Herbicide Branch 

Registration Division (H7S05C) 

OFfICE Of 

PREVENTION.PESTICIOESANO 

TOlOC SUGSTNiC£S: 

PRS has reviewed the claim of similarity and made the following decision regarding 

whether the EPA registered product(s) cited is similar: 

[.f] The suliject product is not similar to: Reg. no. 264-418, 264-276 or 51036-ERO 

General Conunents: Reg. no. 264-418, 264-276 and 51036-ERO contain less Ethephon 

(active Ingredient) than 51036-ERI. The increase in the percent of Ethephon may affect the 

acute toxicity profile of 51036-ERI by Increasing its oral and/or derrnai toxicity. This would 

in turn call for a change in the precautionary statements. 

NOTE: This memo pertains only to the decision concerning whether the suliject product 

Is similar to the cited product(s) from an acute toxicological v1ewpolnt_ PRS bas not 

determined if the data base Is complete for the product(s) cited or If the precautionary 

labeling Is correct. 

*Inert ingredient information may be entitled to confidential treatment*
! 

L 

NOT P..J,",:\1IT;;,TZD 

In Accordance "itt i'R Notice 82-2, 

• 

• TM PREP BRAND 

Baeed 0'4 Draft Labelin. Dated 10' ;;J.!i- 'L'? 

ETHEPHON FOR COTTON AND TOBACCO 

For Commercial Use Or Agricultural Use Only. Not For Residential Use 

ACTIVE INGREDIENT: Efhephon (2~Chloroelhyf) phosphonic acid· ....................................................... 55.4% 

INERT INGREDIENTS: ......•................................................................................................................ 44.6% 

'This product conlains 6 pounds elhephon por gallon. 

EPA Rog. No. 264-418 EPA Es!. No. 254-PA-01 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

Sr usted no entionde fa etiquota, busque a alguien para que so Ia oXpHqUD 11 usted &n dolallo. 

(If you do not understand 1M Jabal. find someone to explain it to you in detail.) 

For MEDICAL And TRANSPORTATION Emergencies ONLY Can 24 Hours A Day 1~800-33(.75n 

For Y..S.&. Information Call 1-800·334~9745 

Tho use of this product for a variety of plant groWlh regulation Uses are protectod by United States and foro n patents including 

U.S. Pat\'lnts 38,79t,188 and 4,240,819. No license is granted to use fhls product in countriesothor than the United Stilter; or for any 

not contemplated by Ihis label. Liabilily for patent intrlngement may result from use or sale of this product outside the United 

STATEMENT OF PRACTICAL TREATMENT 

IF fN EYES: Hold eyalids open and flush with Ii gentle stream of water for at least 15 minutes. Get medical attantion, proterably an 

ophthalmologisJ. 

fF ON SKIN: Immediately wash skin with plf1nty of soap and water. 

fF SWALLOWED: Do not induce vomiting. Promptly drink a large quantity of milk, egg whites, gelatin solution or if those am not 

available, drink large quantities of water, Avoid alcohol. Call a physician immediatoiy. 

fF INHALED: Remove victim to fresh air. H not breathing, give artificial respiration. Administer oxygen if necossary. Get modical 

attenlion. 

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

CORROSIVE. Causes eye and skin damage. May bo fatal if absorbed through skin. Harmful if swallowed or inhaled. Avoid breathing 

•

pray mist. Do not got in ayes. on skin or on clothing. Keep away tram domestic animals. 

WTE TO PHYSICIAN 

There is no 5pOCniC antidote. All treatment should be based on observed signs and symptoms of distress in the pation!. Overexposure 

to malarials othor than this product may have occurred. 

Victims of seveJQ ovoroxposuro, by ir'!halation, shOUld be kept under modical observation for up to 72 hours for defayed onset of 

pulmonary ooema, In a victim of over·ellposure by ingostion, caretul gastric lavago is required due to the possibility ot stomach or 

esophagoal perforation. This material is an add. but usa of alkaliM substances to neutralize it is contraindicated. 

PERSONAL PROTECTIVE EQUIPMENT (PPE) 

Applicators and othor handlers must wear coveralfs over short·sleoved shirts and short pants, waterproof gloves, chemical-resistant 

lootwear plus socks. protective oyewei1r. chomical-fOsiSlant headgear for ov~rhead OXPOSUfO and chemicaf·rosistant apron when 

cleaning oquipment or mixing and loading. 

Discard dothing and other absorbed materials that have been drenched or heavily contaminated wilh this produ£~~rtcentrato. Do 

not rouse them. Follow manufacturer's insfruclions for cleaning/maintaining PPE. If no such instructions for wash~blos~ use dot'1~;~' 

and hot wator. Koep and wash PPE separately from othor laundry. : ••••• • • 

Whon handlors USQ closed systoms, onclosod cabs, or aircraU in it manner that moots the raquirements listed in th~ W~ri<&r Prore~k,p: Standard (WPS) for agricultural pesticides {40 CFR 170.240 (d) (4-6)J, tho handler PPE requirements may be roducect or modifiod as 

specified in tho WPS. .:. ..: ••• 

User Safety Recommendations 

Users should wash hands before eating, drinking, chewing gum, using tobacco or usIng tho toilet. 

Remove clothina immediatelY [f oestlddo Qots insido. Then wash bodv thoroughlY and out on dean c\01hinQ. 

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28 

••••• 

•••• - - , 

- •••• -

- -- -
ENVIRONMENTAL HAZARDS 

Do nOI apply directly 10 wator, or 10 areas whore surface water is present or to intertidal areas below the moan high water mark 00 nol 

contaminate waltH when disposing of equipment washwators. 

Do not contaminate wator usad for irrigation or domestic purposos. 

USE PRECAUTIONS 

Do nol apply PAEP'n1 brand Elhophon throUgh any typo of irrigation system. 

Avoid spray drift to nearby crops as this product will cause modifications in plant growth. Plant injury or reduced yiolds will result. 

00 nol plant another crop within 30 days after Iroatman!. 

Mix only the amount of spray you oxpect to use each day. Do not allow mixed solution to siand overnight 

DIRECTIONS FOR USE 

It Is a violation of Foderal Law to use this product In a manner Inconsistent with Ita labeling. 

Read entIre label before using this product. 

Do not apply this product in a way that will contact workers or other persons, oither directly or through drift. Only protected handlers 

may be in the area during application. For any roquirements specific to your State or Tribe, consult the agency responsible for 

pesticide regulations. 

~:~EE;:11 this product for only the in protection accordance of a9ricu~ural 

with its labeling workers and with on farms, the Worker forests, Protection nursaries, Standard, and gnH~nhouses, 40 CFR part and 170':11~?~[:~~~f~;~~!1 It contains reqUirements for training, decontamination, notification, and emergency assistance. It 

i and exceptions portaining to the slatements on this label about personal protective equipment 

workers and restricted-entry intervals. The roquiromenls in this box only apply to uses of this product that are cOv.,'''' 

Protection Standard. 

Do not entor or allow wOrker entry into troatod areas during the rostricted-ontry int$rval (REI) of 48 hours. 

PPE roquirod lor early entry to treated areas that is permitted und~H the Worker Protection Standard and thaf involves contact 

that has boen traatod such as plants, soil or wattar is coveralls over short-sleeved shirt and short pants, waterproof glovos, 

I . footWear plus socks, protective Gyewear and chemicat·resistant headgear for overhead exposure. 

Ii I 

I."M''''E 

I Do 001 contaminate wator, lood. or teed by slorago or disposal. 

II container is broken or contenls have- spitled, follow all precautions indicatoo above and clean up immediately, Before de"o'ng 

on full length trousors, long sleQved shirl, protective gloves, and goggles or face- shield. Soak up spill with absorbent 

sand, earth or other suitable malOriat and dispose 01 waste at an approved waste disposal faclilty. 

D1SPOSAL 

Ip,"ddl. wastes are acutely hazardous. Improper disposal of excess posticide, spray mixture, or rinsate is a violation ot Federal law. 

wastos cannot be disposed of by use according to labol inslructions, contact your Slate Pesticide or Environmental Control 

~:~~AO::'~lt~h,~e Hazardous Waste reprllSentative at tho nearest EPA Regional Office for guidance. 

D1SPOSAL 

{or equivalent} the empty conlainers, Than offer for rocycling or reconditioning, or puncture and dispose of in a sanitary 

incineration or if aHowed by stato and local authoriUes, by burning. If container is burned. stay out of smoke. 

-- REFILLABLE CONTAINERS 

, return the container to the point of purchase or designated locations. This container must only be refilled with PREPl)'! 

lor Cotton and Tobacco. 00 NOT REUSE THE CONTAINER FOR ANY OTHER PURPOSE. Prio, to rlillilling, '",p""1 lor damage such as cracks, punctures, abrasions and damaged or worn OUl threads on closure devitU,· 'tTo not 

or leaking containers. Check for leaks after refilling and before transportation, For on' 

contact Ah6ne-Poukmc at1-S00-334-974S. For information on cleanup of '11 

,II 

GENERAL INFORMATION • ••• • •••• • • •••• • 

COTTON •• :.: • 

••• ••• A loliar spray of PREpl!.l brand Ethephon will accelerale opening 01 mature unopened colton bolls and enhanco del6l1aJion whicll·oon • 

rosult in earlier harvest whh an increased rocovorabla yield. PREp!">! brand Ethephon treatmont on cotlon allows incro3ied elliciencY· 

Irom a once-over harvest. : ••• •• : •• : 

•••• • ••• 

• 

• • • 

•• •• 

29 
TOBACCO {FLUE~CURED}: A foHar spray of PREP'lA brand Ethephon promotes early, uniform 8yellowing~ of mature tobacco. 

PREPn; r(?duces curing time, allowing more officient use of curing barn spaco, and increased control ovor harvest schlKlules. 

SPRAY PREPARATION 

Add 1/2 to 3/4 of the requlr&d amount of waler to the spray tank, Start agitation. Add the required amount of PREPn! brand Ethephon. 

and the remaining amount of water, Prepare only as much spray solution as can be used on the day of mixing. Do not allow spray 

solution to stand overnight. Do not spill tho concentrated product on spray equipment. or any airplane paris. 

ANY SPIllS SHOULD BE RINSED IMMEDIATEl YWfTH PLENTY OF WATER 

Use of a nurse tank Is highly recommended for avoiding possible spills 01 concentralod tormulation on spray equipmont or any airplane 

parts, 

TANK MIXTURES WITH DEFOliANTS AND INSECTICIDES 

PREP1M brand Ethephon is compatible wilh DEF1, FOlEX~, Dropp2, Harvade3. Methyl Parathion, Guthion 1, and Malathion'!, PREpn, 

may be applie<l in soquence or as a tank mixture (DO NOT TANK MIX WITH DESfCCANTS IF COnON IS TO BE SPINDLE 

HARVESTED). Follow all applicable use precautions and rate per acro recommondations on labels of products applied as tank mixtures 

or in sequence with PREP nI brand Ethephon. In some cases slight re<luClion in boll opening rosponse has beon observed when tank 

mixes with defoliants were used. 

Good agitation in the spray tank is essential and a tank mixture should not be allowed to stand without agi\aUon for more than 5 to to 

m'lnUles, Read and obsoNe all appropriate label use direClions and precautions for the deloliants and insecticidos used. 

NOTE: Under certain conditions, tank mixtures of PREpl>! brand Ethephon with dosiccants containing sodium chlorato could 

result in the formation of hypochlorous acids which on heating will emit toxic chloride fumes. 

EQUIPMENT CLEANING 

6eocause of tho acidic nature ot this product, prolonged oxposuro io spray doposit will damage acrylic plastics, certain paints. and 

"'etat5. 

Rinse thoroughly with a detergent and water all exposoo acrylic plastic·typa materials {e.g .• aircraft windshields}, and painted surfaces 

within an hour after exposure to spray deposits. 

At the and of .ach day, rinse thoroughly with a detergent and water all the metal parts of the aircraft and tho associated spray 

equipment oxposed to the spray deposits . 

• 

• • •••••• 

• 

• • •••••• 

• 

• 

.. • , 

• 

• • •• · ., ., . 

• 

· . , .. . •••• 

• • · ., •••• 

30 

. •••••• ., • • ....... • ., • 

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••••• 

• 

• ••••• 

• ., • 

. ... ~ . • • 

• ••• 
COhON 

EXPECTED PREP1"\! ONE SPRAY VOLUME APPLICATION 

USE CONDITIONS RATE GALLON (Gals/A) TIMING 

PREpN 

LBS A.1. Acr •• I ro, Air" 

PREPrv Hot Md dry BOGF or I 113 1.0 6 Apply when tho numbor of 

Bol! Opener· higher mature unopened bolls is 

Dry and 75 to 80QF 2 1.5 4 15 -50 2·5 sufliciont 10 produce /~ro~ desired crop. Soo below 

Cool but above 65QF 2213 2.0 3 lesl of bol! maturity. 

Treatmant unilormly opens 

or bolls 710 14 days earlior. I Rook coHoo 

PREp'!.! + High soil moisturo 113 0.25 24 15-SO 5·10 Apply 4 10 7 days prior to 

FOlEX* or PREPm boll opening 

Oofollanl Tank High fertility level application. To be used as 

MIX a soquontla! trealment with, 

or not j~-pl~o ,01 PREpn.l boll I Rook coHon 

n;r-.,. Dfopp2 High soli moisture If3 0.25 24 10 ~ 50 3- 10 Apply 4 10 7 days prior to 

DaleUanl Tank High JoniJity level ~~~.~_~_ boll opening 

Mix r To be used as 

Rank collon ~.: Irealment with, 

001 ;? p1~",,_.01 PREpN boll 

Pre-Conditioner ~,dry,above 800F 2/3 0.5 12 Apply 4 to 7 days prior to 

lor Defoliation Cool, above 65~F I 113 1.0 6 t5 ·50 2·5 defoliant. Enhances top 

or crop delolration reducing 

detorioration of bottom crop 

Rank cotlon aod allows let earlier 

·Pretreatment With Defoliants Prior to PREplM Boll Opening Treatment 

II the cotton is ovorly rank or laying down in the middles and good spray coverage of the boUs with PREp1'loI is difficult, D. protrcatmont 

with defoliants wi!! be useful to improvo boll coverage with PREpnt, Use dosage ratos of PREpOi brand Ethophon rocommended for bal! 

o~ning. Read and observo aU appropriato label use directions and precautions for the defoliant usod. 

"In Cali/ornla and Arizona use a volume of no less than 5 gallons per aero lor aerial applications. 

_0Il Maturity 

... boll is mature when it is too hard to be dentod when squeezed between thumb and lingers, too hard to be sliced with a sharp knife, and 

wh~n the soed coat becomes light brown in color. 

Use Limitations 

Do not exceed a maximum of 2.0 lb. ai/A for combinG(! uses of PREpl" por acre por year. 

BoH Opening: Do noltank mix PREPI)'! brand Ethaphon with a desiccant il the cotion is to bo spindle harvested. 

Pro-Condition lor Defoliation: Do not tank mix PREP'" with desiccants unless plant desiccation Is required. Do not use a deloliant 

before thore is sufficiont mature unopened bolls to produce tho dosired yield (sao General Information soction on how to test tor boll 

maturity. 

WHEN TO HARVEST COTTON 

Do nOf harvest cotton soonor than 7 days aftor a treatmanl with PREP)'" brand Ethophon. • • •••••• 

ObsoNe the traated crop and harvesl whon optimum boll opening has been reached. Too early harvest might rodu~e the tull advtl'l.: 

of the treatment and too lata a harmst may result in reduced quality and loss of lint which will drop lrom the plant : ••• :. • • 

• 

• 

• •• • 

• 

• ••• . • • , . 

• . .. . , . ••• • 

• • 

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31 

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••••• • • 

••••• 

• 

• ••••• • ., • 

• ••••• • • 

• ••• 
PREpn. 

Crop Silualion Pfnta/Aer. 

Directed Spray t t/3 

Applicalion 

Over·The-Top 1 tl3 - 2 213 

Application 

USE LIMITATIONS 

TOBACCO 

(Flue-Cured Only) 

8' Specific Directions 

50-60 

40-60 

Use drop nozzfes_ Choose TG or OC spray tips designed to apply 50 . 60 

gpa at 35-40 psi and at tractor speed of 2-3 mph. Use 

2 nozzles PGr row; one on aach side of the row dropped low enough to direct 

the to the loavos to be ripened and harvosfed. Thorough spray 

cml.".& is essentiaL With a directed spray. I>e sure to harvest all leaves 

I . 

Troat only whon lea 'lOS remaining on the stalk are maturo. 

remaining leaves are mature, tast spray soveraf tobacco 

described under the section ·Proper Ttme 01 Treatment." Usa the 

in a normally mature crop when experience indicates that minimum r,,,,""" 

inducement is required. Use the higher rate when the crop Is heavy 

a tendency to be more rank or whon temperatures are lower than I 

Always test spray to determine if the tobacco is mature enough to respond 

to treatment with PAEpm brand Ethephon. 

Apply over-the-top PAEpm brand Ethephon spray as a fino mist using Ihr09 

nozzlas (one nozzle tips over the center 01 tho plant, and on each ' 

so all leaves are covered similar to the 

Do not apply PREpn. brand Ethephon to immature IGaves as this can result in unsatisfactory coloring, weight loss and reduced loat 

quality. 

00 not allow the crop to over ripen in tha field after using PREP'" brand Ethaphon, since this may causa some reduction in yield and 

quality. 

Do not treat beforo anticipated major storm which could prevent harvest and result in crop loss. 

00 not apply PREp1~ brand Ethephon if rain is oxpedOd w[thinA hours. 

APPLICATfON TIMING 

Successful results with PREP1~ call for troatment when loaves are mature. not overly rank green when sprayed. To easily determine 

the pioper troatmont timing and tho number of leaves p0r stalk ready for harvest, tO$t spray soveral plants in more than one location in 

each fiold and obs .. uve tho response. Mature loaV05 will bagin to yellOw in 24 to 72 hours. Test laav9s that fail to yellow In 72 hours are 

not mature and ar€l not ready for PREPn1 brand Ethephon treatment. Wait a tew days to parmit further natural maturing. thon make 

another tost spray or ~maturity" check. 

_ When you have conlirmed the number of leaves por plant that will color, you can dotermino the number of acros to treat in ordor to lill 

o barn. 

ropare your tost spray by mixing one teaspoon of PREpl'l in 1 quart of wator. Spray oach test plant with about 1 oz. of this mixture, 

covering alileavas with a line mist. PAEP!~ brand Ethophon will not color immature sprayed loaves. 

WHEN TO HARVEST 

AI! malure, sprayed lGavGs will begin to color within 24 to 72 hours after PREpl'" brand Ethep!1on application. The yellowing process is 

woather dependent; cool weathor will delay, while hot. sunny weather (".an speed up the process. Harvest treatoo tobacco when leaves 

have roached tho desired color intensity. 

Do not allow tobacco to become over ripe botore starting haNest. Loaf drop can occur when tobacco is over ripe and laft on thG stalk. 

If a number of tho boltom leaves have yellowed at the timo of trealment, they should be harvosted prior to spraying with PAEPT"I brand 

Elhephon. 

With an over-the·top application, harvesting can commence 24 hours aftor PREptv brand Ethephon application depending on weathor 

conditions or to avoid ovor ripe tobacco. Tobacco harvested 24 hours after treatment will require more timo in the ~g69 phase of the 

curing process. - ___ --- • • • CURING PREplM TREATED TOBACCO : ___ :_ - -

Curing prOCedures are as much an art as a sciencQ and each cure must be judged on the basis of tobacco conditi6n, interval bE!tt41M! 

lroatment and harvest, weather and typo of curing facililY boforo proscription tomperalura and ventilation sc:h-edulos can M 

established. To obtain maximum quality, care must be taken to obsarve and c:onlrol tho curing process closely, esPi!i.lly duri"!J'~I!_ 

late ~coloring~ and early ~dryin9· stages ot the leaf. - ____ _ 

PREpI'M brand Ethephon treated tobacco will have started the coloring process when harvested, reducing the time r9C{ui~n the -

coloring phase of curing. Treated tobacco should be dried faster. II tobacco leaves are green or contain some groen w~en harve:n~:-: 

it may be necessary 10 color thom for a lew hours. II the leaves am completely yellow, temperature and ventilation must be adjusted iftn manner to dry the tobacco as fast as possible without scatding. Once the leaf is driGd (3/4 dry), you should follow t1lrq,'W ,.rocedti~-! 

tor curing. Sinc~ PREpn. brand Ethephon troated loaves cure faster, treatod and untroatod leaves should not be curGt.l'·16~ether 1n>ttie"'-

same barn. - _ : 

-- _. 32 
r-------------------~-.... ~-... --

LIMITED WARRANTY AND DISCLAIMER 

The manufacturer warrants (a) that this product conforms to Iho chemical doscription on tho label; (b) that this product is roasonably lit 

for the purposes sot forth in the directions for use whe-n it is used in accordance with such directions; and (e) Ihal tho dirOClions. 

warning and other slalamonls on this labol arc based upon responsiblo experts' evaluation of reasonablo tosts of effoctivenoss, 01 

toxicity to laboratory animals and to plants. and 01 residues on food crops and upon reports of !laid oxporienco. Tosls havo not boen 

made on all varietios or in all stalos or undor all conditions, THE MANUFACTURER NEITHER MAKES NOR INTENDS, NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE, ANY OTHER WARRANTIES, EXPRESS OR IMPLIED, AND IT 

EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANTIES OF MERCHANT·ABILITY OR FITNESS FOR A PARTICULAR 

PURPOSE. 

THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND ALL LOSS OR 

DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE LABEL 

DIRECTIONS, WARNINGS OR CAUTIONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, 

LOSSES, DAMAGES, OR INJURIES RESUL TlOO FROM THE USE OR HANDLING OF THIS PRODUCT, WHETHER OR NOT BASED IN 

CONTRACT, NEGLIGENCE, STRICT LIABILITY IN TORT OR OltlERWISE SHALL BE LIMITED, AT THE MANUFACTURER'S OPTION, 

TO REPLACEMENT OF, OR THE REPAYMENT OF UIE PURCHASE PRICE FOR, ll-1E QUANTITY OF PROOUCTWITH RESPECT TO 

WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, INDIRECT OR 

CONSEQUENTIAl DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT. 

NOTICE TO BUYER 

Purchase of this product does not confer any rights under palienls governing this product or the use theroof in countries outside 01 the 

United Slates. 

--DEF and Guthion are registered trademarks ot Bayer AG, Germany. 

2Dropp is a registored tradomark ot NOR·AM Chemical Campany. 

3Harvado is a rogistorO(l trademark ot Uniroyal Company. 

4Malathion is a trademark of Amadean Cyanamid Company . 

• 

RhOna·Poulonc Ag Company 

P.O. Box 12014, 2 T.W. Alaxander Drive 

Research Triangle Park, North Carolina 27709 

PREP is the trademark 01 Rh6no·Poulonc. 

FOLEX is a registeroo trademark 01 Rhone-Poulonc. 

PREPTM brand Elhophon tor Cotton and Tobacco (MASTER) ApprOVild 10128193. 

• • • ••••• 

• 

• • 

••••• • • 

• 

•• · • • .... 

• •• 

•• • 

· .. •• • • ••• 

• • · .. •• •• 

33 

•••••• • •• 

• • 

•••••• 

• .. • 

••••• • • 

••••• 

• ...... • • •• . ..... 

• • 

•• •• 
• • 

• • 

Mr. Warren A. Davis 

Rhone-Poulenc Ag Company 

P.O. Box 12014 , 2 T.W. Alexander Drive 

Research Triangle Park, NC 27709 

Dear Mr. Davis: 

Subject: Revised Basic Formula 

PREP Ethephon cotton Boll Opener /' / 

EPA Registration No. 264-418 ~ 

Your Submission Dated August 18, 1993 

The revised basic formula is 

in the files for this product. 

accepted ones. 

acceptable and has been included 

It supersedes all previously 

"Sincerely yours I 

Cynthia Giles-Parker 

Product Manger (22) 

Fungicide Herbicide Branch 

Registration Division (7505C) 

34 
• • 

• • 

REG. NO: d (p 1. -'1;p mE SYMBOL: __ _ 

REVIEW FOR END USE PRODUCTS 

TO: 

FROM: 

PRODUcr CHEMISTRY 

PM .;)~ 

.~ BLsfc" 

PRODUCT NAMES: Pree fi/a"f- f-eyyhfor~ 

Fw {,~fI", 

THRU: . .Jl,_.fg.i.~.:! 1- (V 

CHEMICAL: • 

------ MR1D NOS. ___________________ _ 

Food Use' _______ _ Non Food Use _______ _ 

Ineru cleared: c ()d () e () yes () no () 

lnens List 1 ( ) Other ( ) 

Please provide the requested infonnation for the following checked items: 

1. [1 Submit the product specific product chemistty data for your product. I I If 

submined earlier. provide MR1D Nwnber(s). I I Your product is not sufficiently 

similar to the product your referenced. 

2. In ",Celencc to the Confidential Statement of Fonnula (CSP). please provide the 

foUowing: 

[1 a) pH of product at a specified water dilution. 

[1 b) Density of product. 

[ 1 c) Fluh point of product. 

[1 d) FI&IIl point of product with propellent as per item #6(q) or item #5(c). 

[1 e) Flash extension of product including flashbacks if noted. 

y/..... ~/fov I} -:b/~ ~.~ ~ (~tJ.-?~'1-SI1 " 

i 

• 

35 
-2-

[] t) TIle upper and lower certified limits based on the pure active ingredientS 

rather than the technical or concentrate. 

[J g) The upper and lower <:<rrified limits of the individually added inens. 

[J h) 

[J i) 

[J j) 

3. Based on the current CSF dated • your product will not mee' the 

label claim for the active ingredient. Please revise the label or the CSF so that the 

information agrees. e 

4. Provide the chemical identify of all components. the percentage composlllon. CAS • 

Registry Number. and Material Safety Data Sheet (two copiea) for the following 

compounds: 

I. 

2. 

3. 

4. 

5. 

The supplier may contact EPA directly ~ferencing the Pile Symbol of EPA 

Registtation Number in their response. Por dyea. provide the oolor index and CAS 

Registry Numbers for all components. Por perfumes and flavorings. provided for each 

component in the mixtwe: the cber:nicol =. CAS Registry Number. and the 

percentage or ranae in percentage in the mixtwe. Certify tha< flavors are non-food 

type. Tho C""fidential infomution submirted by the suppliers is kept oonfidential 

Wlder FIPRA Section 10. 

5. In the proposed' labeling. provide the following infomution: 

[J a) Update the label Storage and Peaticide and Container DispoIal Statements 

in accordance with [ J PR Notice 84-1 for non-aerosol cootainers for houses 

and institutional ..." of [ J PR Notice 83-3 for all other woes. 

36 

• • 
• • 

• • 

-3-

[J b) Add the heading PHYSICAL OR CHEMICAL HAZARDS to the label and 

the appropriate statement per 40 CFR 156.10(h)(2)(ili). 

[J c) Under the heading PHYSICAL OR CHEMICAL HAZARDS, list the product 

as extremely Aammable (because your product contains flammable 

propellents). 

[) d) Provide that the solvent does not have insecticidal activity, it should be 

removed from the ingredient statement active ingredient listing and the 

percentage added 10 the inert ingredients. If the solvent bas insecticidal 

-propenies, provide the EPA Registration Number. 

[J e) Add. footnote to the inert ingredients indicating: Contains 

(] t) Since your data matrix does not provide a dielectrical breakdown voltage, you 

must add the following statement to the physical or Chemical Hazards 

heading; 

Do not use this product in or on electrical equipment due to the 

possibility of shock hazard. 

[J g) The terms active ingredient(s) and inert ingredients should he in the same 

type size, he aligned to the same margin and be equally prominent. 

[1 h) 

[1 i) 

6. In reference to the product spocific data requirements, provide the following 

infoanation: 

[J a) Statement of Composition: A complete description of the manufacturing 

fonnIJlation process. Describe equipment used, 1l1ixJng time, temperature, 

pressure, etc. 

[J b) DilIctwion of Fonnation of Unintentional lngrediento: A brief description of 

impurities formed dnring the manufacturinglfortnulation process, in packaging 

or during storage. If you do not expect any impurities during these stages, 

please so state. 

[1 c) Certification of Limits: Upper and lower lintits or each active and 

individually added. inert component. 

37 

*Inert ingredient information may be entitled to confidential treatment*
[1 d) Analytical Method: Provide the methods used to analyze for the active 

ingredients or a full reference for a published method or MRID Nwnber(s) 

[J e) Color: In conunon ICons. 

[J f) Physical State: e.g .. solid. liquid. pressurized liquid. etc. 

(J g) Odor: In common terms 

[J h) Density: e.g .. lbs/gallon for liquids or lbs/cu.ft for solids. 

[ 1 i) Ph: Provide pH of product or pH of a specified water dilution, 

[ ) j) Oxidizing or Reducing Action: Note these characteristics. if any. 

[ ) k) Explodability: Note these characteristics. if any. 

[ ) 1) Viscosity: Can be expressed in centipoise or centistoke. 

[J m) Miscibility: Note these charactedstics if product is an emulsifiable liquid aod 

mixed with oil. 

[J n) Corrosion Charac1eri8tics: This infonruttion can be noted during !he storage 

stability stUdy. 

[1 0) 

[1 p) 

Dielectric Breakdown Voltage: For products used oeor electrical equipment. 

Storage Srability: The formulated product inoo be analyzed for its active 

ingredients at time :zero aod during one yeat of storage. The storage should 

• • 

be at w_ conditions of temperature aod bumidity aDd IIIored in!he • 

product" commetciaI package. Note: For the storage stability stUdy, you 

may not reference the data on source product concemrare you are using to e 

formulate your product. 

[1 q) P1ammability: P1aah point/flame extension. The flaah point reponed exceeds 

the one expected for this product. PIe... check aDd resubmit. Mixtures 

marketed under preas""', including !hose containing hydrocarbons, are subject 

in their entiIety to tests indicated in 40 CPR Section 1S6.1O(bX2)(ili) of the 

maxipackag.. Note that flash pomts for pressuri=d liquid from !he container 

[1 If any of the items are not applicable, write N.A. and explain IUSons are specified 

under chemistry data requirements footnotes. See 40 CPR Pan IS8. 

38 ~.------
---.-.. - ... - .. - .... - .. -

• • 

• • 

-5-

7. [1 The following is the regulatory stalUs of the inert ingredients under 4Q CFR 

180.1001 for for the exemption of the requirement of a tolerance. 

8. Other 

Note to PM; lnter-<>ffice use only 

SUMMARY ATTACHED 

39 
• • 

• • 

I 

I 

I 

I 

TAlILBi 1: S~ or PRODUCT CHBMIS~ DA~A RBQUIRZMBNTS 

""'. I "",.. II ~ Ii:I.-Pro<koct I~U"T ....t ~1.U- (40C11UJ', 1$5. "0, UZ. , .... .. " 

H-l , PI:"KIl¢t tduttit.'1 , tH •• ~luu:. of l .. 'f\':...u. .... U 

41-. C •• "'="1>,,10 .. ot StLnU'I lUtarj,."h , KuI .. hctuu.., p"" ••• 

H-l ::a."" •• ~= .. 01 r<ll"MAt1..ft '>t :.;.....,,\.':.1 •• 

kra. U-kwLI.",U -.d e.rt.J,.t1. ... u- .t ~ ,.,...,..'" !'~"1'I'O, 115 , 110) 

'2-1 t>1:".l~ .. ary ~ly.1.. ot t/:"cdoct $ ... 1 •• 

u-z c..r1:1tiUtho ot btT..uou, I.J.a1U 

u-, ..... "l1"=1.c.al KetlilO<U to V_J.ty C&r.::.t:,M W&.I.U 

__ s... n-flI.~ Md a..i-.1 ~_ {4oc:raJ..M. HOI 

u-: ~ ... U·l '11.111.:.111 Stat" 

U·' -. 

u·s KdtUq 'eLae 

fl·' loJ,.ll1Iq 'eLat 

fl-1 o-,.i,.\: • ,tUlt o-..j,.o: , O~ ~1." Qc.~1.t 

fl-, "lll&:U1.ty 

fl-' V~I:" r~.-..r. 

U-tO D~.o~t1." eo&.taat 

43-1J. ~ol./1kt_ P&rtJ,.titICI c-lf.l,.o.i_t 

41-U .. U~U n_U1li:y 

1)-14 Od,41.s1aq ~ ....... .., Adt.to. 

u-u r~:UJ.tl' , 

U-14 ..,JAo4MLJ.J.tJ .. 

4:)-11 Itt.o_ 1t.bllJ.ty 

u-J.t \!'u_.1ty 

u-u .......w, , 

U_%O c.co~ ~_.uu .. 

U-H D~.l,..~VolUp 

.\ • .\ac~"J.. 

______________________ __ 

• W.u"'" 

au. lfot Aflpl.l.Hl>l. .t."'1:1 .... I_ti, ___________________ _ 

!Xi DOl:"o'::"l' 

O.t., 

40 
• <. 

OF BARCODE: 0194604 

CASE: 003396 

SUBMISSION: S446994 

DATA PACKAGE RECORD 

BEAN SHEET 

* * * CASE/SUBMISSION INFORMATION * * * 

DATE: 08/31/93 

Page 1 of 1 

CASE TYPE: REGISTRATION 

CHEMICALS: 099801 Ethephon 

ACTION: 345 TECH-FORMULA CHANGE AMND 

55.4000% 

ID,: 000264-00418 PREP PLANT REGULATOR 

COMPANY: 000264 RHONE-POULENC AG COMPANY 

PRODUCT HANMER: 22 CYNTHIA GILES-PARKER 

PH TEAH REVIEWER: JAHES STONE 

RECEIVED DATE: 08/26/93 DUE OUT DATE: 

FOR COTTON 

703-305-5540 

703-305-7391 

11/24/93 

* * * DATA PACKAGE INFORMATION * * * 

DP BARCODE: 194604 EXPEDITE: N DATE SENT: 08/31/93 

4IHEMICAL: 099801 Ethephon 

p TYPE: 001 submission Related Data Package 

_SIGNED TO 

CSF: Y LABEL: N 

DATE IN DATE OUT ADMIN DUE 

DIV : RD / / / / NEGOT 

8RAN: RSB / / / / PROJ 

SECT: PCRS / I I I 

REVR : / / / / 

CONTR: / I / / 

* * * DATA REVIEW INSTRUCTIONS * * * 

Review revised basic formula 

* * * DATA PACKAGE EVALUATION * * * 

No evaluation is written for this data package. 

ROOH: CH2 

ROOH: CM2 

DATE RET.: / 

DATE: 10/15/93 

DATE: 10/15/93 

DATE: I I 

* * * ADDITIONAL DATA PACKAGES FOR THIS SUBMISSION * * * 

BRANCHjSEC'rrON DATE OUT DUE BACK INS CSF 

41 

229 

247 

/ 

LA8EL 
~j {Il/\ 

~~~~~~~~~=,-,-=-=~==~-==-~ 

• • 

• • 

RHONE·POUlENC AG COMPANY 

ETH93·24 

August 18,1993 

U. S. Environmental Protection Agency 

Office of Pesticide Program Document Processing Desk 

Room 266 A, Crystal Mall No.2 

1921 Jefferson Davis Highway 

Arlington, Virginia =02 

Attention: Ms. Cynthia Giles~Parker 

Product Manager (22) 

Fungicide Herbicide Brandl 

RegisLTation Division (H7505C) 

Dear Ms. Parker: 

RE: PREP® Brand Ethephon Cotton Boll Opener 

EPA Reg. No. 264·418 

On May 24,1993 you advised us that a source of supply for the basic formula lion for PREP® 

Brand Ethephon Cotton Boll Opener should be idenlified. Please be advised that the source of 

supply is Base 250 (EPA Reg No. 264-511) the same as for the current alternate fonnulalion on 

file with EPA A new umfidenlial statement of fOflnulation is appended to identify the source 

of supply. With the exception of the addition of the regislration number for Base 250 in block 

12 lhere are no other changes from the formulation statement filed on January 1, 1993. 

If you have any addilional qUL'Slions please contact me prompUy. We appreciate your 

assistance . 

Sincerely, 

/ / /) 

{~{>a~L0~ If /'/;7)(.-,,",-

Warren A. Davis 

Senior Registration Manager ... • 

• 

•• • 

• . , •• . 

• 

., 

•• • . • •• 

•• •• 

• •• 

• • 

• 

• •• 

•••••• • •• • • 

• ••••• • • • • 

• •••• · . ••• •• 

• 

• ••••• 

• • 

• ... ..... . f>,:>eox t:!C11 :: 1 'N.f,t FlN,;:'U1 ()">;i' 

R~SFJ\G-C" lIl!ANGl to ;"NH ~,c 2 lTV] 

01,))"",10·2(06 

~~Cejj[Jnceilr Pcriortulf¥'x· 

• • P rt!.,r. ~\~,ct1ii:; vpmc r1\ 

It, TfTi',ATlonAL TLi"X i-FJI,t,.'V-l .t;,:!,jji!; "',$'1,'F R2N.::'" /-r< fd" 

1';n::rhATlGt:'\i tw:;-:nUV,Ul S~i),\'IC fS if! [j ',,-,v:c.m n'J'n; " l,t':;I',tPP/·C"; 1'.".:: !;', J 

42 
l 

•• 

PREp TM 

BRAND ETHEPHON FOR COTTON AND TOBACCO 

For Commercial Use Or Agricultural Use Only. Not For Residential Use 

ACTIVE INGREDIENT: Ethephon (2-Chloroethyl) phosphonlc acid- ................................. " .................... ,55.4% 

INERT INGREDIENTS: ........................................................................................................................... 44.6% 

-This product conlains 6 pounds elhephon per gallon. 

EPA Rog. No. 264-418 EPA Est. No. 264·PA·01 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EYES: Hold eyelids open and flush whh a gentle stream 01 water lot at loast 15 minutos. Get medical atlantion, preferably an 

ophlholmoJogist. 

IF ON SKlN~ Immediately wash skin with plenty 01 soap and water. 

IF SWALLOWED: Do not jnrluco vomiting. Promptly drink a large qu .. ntity of milk. 099 whhos, go latin solution or if theso aro nOl 

available, drink largo quantities 01 wator. Avoid akohol. Call a physician immediatoly. 

IF INHALED: Romovo victim 10 fresh air. If not brea1hing, glvo artilicial rasplration. Administar oxygen if n&<:Ossary. Get modical 

attention. 

PRECAUTIONARY STATEMENTS 

-PANGER 

WfjAZARDS TO HUMANS AND DOMESTIC ANIMALS 

CORROSIVE. Causes eye and skin damaga. May belatal if absorbed through skin. Harmlul if swallowed or inhaled. Avoid brealhing 

_pray misl. Do not get in eyos, on skin or on cbthing. Keep away lrom domestic animals. / 

NOTE TO PHymclAN V 

There Is 00 spocilic anlKiote. All tfeatment should be based on observoo signs and symptoms 01 distress in Ihe pationt. Overe)(posure 

to materials oth&f than this product may have occurred. 

Victims of sevare overaxposure, by inhalallon, should be kepI under madical observation for up to 72 hours for dalayed onset of 

pulmonary odoma. In a victim 01 over-exposure by ingestion, carelul gastric lavage Is (4quirod duo to the possibiIJly 01 stomach or 

esophageal perforation. This material is an acid, but use of alkaline substances 10 neutralize it Is contralndicatod. 

PERSONAL PROTECTIVE EQUIPMENT (PPE) . AppIicatofS and other handlers must wear coveralls over short-sleevad shirts and shorl pants. watorprool gloves, <:ha~l.rosislanl 

lootwear plus socks, protective eyewoar, chamical-resislant hoadgaar lor overhead axposure end chemicat·roiJs1ant apron whon 

cleaning euipment. •••• : •• :.: • • • • Discard clothing and olhor absorbed malerials that have been drenched or heavily contaminaled with this productsttltltenttale..Qp •• 

not rouse them. Follow manufacturer's ins:lructions lor cleaning/maintaining PPE. II no such instructions for washables,"use delorgent • 

and hot water. Koop and wash PPE llOparal&1yfrom other laundry. •• •• ••• ••• • •••• 

Whon handlers use closed systems, oocJosod cabs. or aircralt In a manner lhat meots lha requiremonts listOO In the"Worker Prot$;li'bll •• 

Slandard (WPS) for aglicultural pesticides (40 CFR 170.240 (d) (4·6)J. the handktr PPE roqulremonts may be roduteQ",";nodilied a; 

specilied in 1he WPS. •••• • ••••• 

User Safety Recommendations 

Usors should wash hands bolote eating, drinking, chewing gum, using tobao::o or using the toilet. 

Remove clothing immediately if peslicide gets inside. Than wash body thoroughlv and put on clean c{othing. 

• •• 

• •• •• • •••• 

• • • •• •• •• 

43 

••••• • • ••• 
EN)fIRDNMENTAL HAZARDS 

F.ofterrestri8!uso8:)do not appty dlrecliy to water, or 10 areas where surface wator Is jl(osont or 10 (ntonida! aroas below tho mean high 

Wator marlC'UOiffit conlamlnato water whon disposing 01 equipmont washwators, 

Do not contaminate walet used for irrigation ordomoslic purposes, 

USE PRECAUTIONS 

Do not apply PREpl'M brand Ethephon through any type of irrigation system. 

Avoid spray drift to nearby crops as this product wiD causo modifications In plant growth. Plant Injury or reduood yiokls wm result. 

Do oot plant another crop within 30 days after troalmen!. 

Mix only the amount of spray you exPQCt 10 use each day. Do nol allow mixed solution to stand overnight 

DIRECTIONS FOR USE 

It I •• violation of Federal law to use thl. product In a manner Inconsl,tent with It. labeling. 

Road ontfro label bofore using thl. product. 

00 not apply this product in a way that wHi contact workers or othor persons, either directly or through drift, Only protected handlers 

in fhe area during application. For any requiroments spO(:'lflC to your Stale or Tribo. consult Ihe agency rospons'lb!e for 

"""~"'. regulations. 

product only in a.ccordanco with ils labeling and with the Worker Protection Standard, 40 CFR part t 70. This standard 

for tho protection of agricukural workers on farms, fore sis, nurseries, and greenhouses, and handlers of 

It conlains requlremenls for training, decontamination. notification. and emorgency assistance. 11 also 

and expectations pertaining to the statemenls on Ihls label about personal protective equipment (PPE). i 

and restricted-enlry inlervals. Tho requlremenls in this box only apply to USGs of this product that are covor&d by the 

Profoclion Siandard, 

onter or slJow worker entry inlo treated areas during tho restricted-sntry inleNal (REI) of 48 hou/'$. 

roqulrod for early entry to Iroaled areas that is permitted under the WOl'ker Proloction S1andard and that involvs$ conlact 

that has boon treated such as plants, $O~ or water is coveralls over short-sleeved shirt and short panls, waterproof 9IOve.", 

footwear plus socks, protoctlve eyowoat' and chomlcal·resistant headgear for overhead oxposuro. 

not contamlnale waler, food, or loed by storage or disposal. 

conlainer is broken or contents have splll&d. lollow aU precautions indicat&d above and clean up immediately. 8&foro cleaning 

on trousen;, long sloovod shirt. protoctlve gloves, and goggles or fac. shield. Soak up spin with absorbent media 

~'~;~7.;~:~h or other suitable- material and dispose 01 waste at an approved waste disposal faclrtty. 

II DISPOSAL 

I~,"'icid.wasles are acutely hazardous. fmproper disposaf of oxCGSS pesticide, spray mixlure, or rinsate is a viofation of Federal 

wastos cannot be disposed 01 by use according to labef instructions, contact your Stale Pesticide or Environmentaf Co,,.",'1 I~~~:;;~~'::h,~e Hazardous Waste represenlative at Ihe nearest EPA Regional Office for guidance, 

II DISPOSAL 

{~o~~~:~~~~:~::~~~ containers. Then offer lor recycling or reconditioning, or puncture and dispose of in a , .. ,'a'l'l I';~~~~;~'~~ or· by state and local authorilies, by burning. If contalnor is burned. slay oul of smoke. 

I' REFILLABLE CONTAINERS 

• •• • •••• • 

• 

GENERAL INFORMATION 

COTTON 

.. ..... • • •• • •• 

A foliar spray of PAEpnI brand Ethephon will accolerate opening of mature unopened cotton bolls and enhance del"'~i&n whichoono: 

retull in earlier harvesl with an increased recovorable yiold. PREpt"U brand Elnephon trealment on cotton allows lnoreasad efflclanc/ 

lrom a once-over halVest ••••• : 

44 
-- -----

TOBACCO (FLUe·CURED): A foliar spray of PREpn, brand Ethophon promotos oarly, unilorm '"yellowing· of maturo tobacco. 

PAEpm reducO$ curing tlmo, allowing more officlont use 01 curing barn spac." and incroased control ovor harvGS! schoduJes. 

SPRAY PREPARATION 

Add 112 to 3/4 of tho required amount 01 walor to the spray tank. Start ag~ation. Add Iho requirod amount of PREpm brand Elhophon, 

end tho romaining amount of wator. Proparo only as much spray solution as can be usod on tho day of mIxIng. Do not aHow spray 

solution to atand ovornlght. 00 not spin the concentrated product on spray equipment, or any alrplane parts. 

~Y SPiLLS SHOULD BE RINSED IMMEDIATELY WffiI PLENTY Of WATER. 

Use of a nurse tank 18 highly rocommendod for avoiding possible splUs of concontrated lormulatlon on spray equipment or any airplano 

parts. 

TANK MIXTURES WITH DEFOLIANTS AND INSECTICIDES 

PAEpm brand Ethophon Is compatible with DEF', FOLEXs, Oropp2. Harvada3• Methyl Parathion, Gulhicn', and Malalhion~. PAEpru 

may bG applied in sequence Ot as a tank mlxtuta (00 NOT TANK MIX WITH DESICCANTS IF COTTON IS TO BE SPINDLE 

HARVESTED). Follow aU appllcablo UM precautions and rate por aero rocommendations on labels of products applied as tank mixtures 

Ot In soquonce wkh PREP N brand E1hophon. In some casas Slight tedUCIion in boll opening taspen .. has been observed whon lank 

mlxos wkh defoliants ware used. 

Good agkaUon in Iho spray tank Is ossonllal and a lank mixturo should not be allowed to stand wkhaut agitation fat more than 5 to to 

minutes. Road and absotVe all appropriato label use dlredions and precautions tot too defoliants and insodicides used. 

~OTE: Undet CGftain oondkions, tank mixtures 01 PAEpru brand Ethophon wilh doslccants contaIning sodium chlorate could 

• «'I5Uft in the formalion of hypochlorous acids which on heating will emit laxic chlotide fumos. 

EQUIPMENT CLEANING ' 

eB&causa of the acidic nature 01 this product, prolonged exposute to spray deposit will damage acrylic plastics. certaIn paints, and (/ 

metals. 

Rinsethoroughfy wkh a dotergent and water all exposed acrylic plastic-type materials (o.g .• aircraft windshields), and painted surfaces 

within an hout after exposure to spray deposits. 

At tho end of oach day, rinse thoroughly with a detorgonl and water aU the molal parts of the aircralt and tho associated spray 

oquipmont exposod to tho spray doposks . 

• • 

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45 

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' .. 

dOTTON 

EXPECTED PREPT).I ONE SPRAY VOLUME APPLICA TlON 

USE CONDITIONS RATE GALLON (GaIS/A) TIMING 

• LOS A.I. Acr .. .~I["· 

PREPThi Hot and dry 8O"F or 1113 1.0 • Apply whon the number ?f 

SoU Openor" higher maturo unopened bolla ,Is 

Dry and 75 10 aooF 2 1.5 • 15·50 2·5 

sullicienl 10 produce I~G 

desired crop. See below for 

Cool bot abovo S5°F 2213 2.0 3 lest 01 boll malurily. 

Treatment uniformly opens or bolls 710 14 days oarli8f. 

Rank ""on 

PREpnt' + High soil moisture 113 0.25 2. IS-50 5-10 Apply 4 10 7 days.pr.Ie'.'O FOLEX· or PREpllI boll I 

Tank High lortility Iovel a~bmlen. TO_b&-;'~M 

Ix or 

a SO<'!uential 

nol in boll 

Rank coHon I 

High soil moisture 1/3 0.25 2' 10-SO 3 ·10 Apply 4 10 7 days prior 10 

Defoliant Tank High fortility level PREp"N boll opening 

Mix Rank cotton application. To be used as 

a soquonliallroatmenl with, 

not in pl~,of PREpnt boll 

Pr.·Condltfone( Hot, dlY. aboVe 80~F 213 0.5 12 Apply 4 10 7 days prior 10 

for Defoliation Cool, abovo ssoF 1113 1.0 • 15 ·50 2·5 dofolianl. Enhances lop 

crop defolialion reducing or dolerioralion 01 bonom-c.~p Rank cotlon and allows lor earlier 

*Pratreatment With Defoliants Pnor to PREpru Boll Opening Treatment 

IIlhe coHOn Is overly rank or laying down in Ihe middies and good spray coverage of Iho bolls with PREpDI Is diffICUlt. a pretrealmenl 

with defoliants whl be usofullo improve boll ooverage with PREpn.!. Use dosage ralos of PREP'"" brand Ethophon recommondOO for bon 

~nlng. Road and observe aU appropriate label use directions and precaulions for Iho dofoHanl used. 

·*In California and Arizona use a volume of no loss Ihan 5 galloos per aero lor aorial applicalions. ft:'OU Maturity 

A bon is mature when il is 100 hard 10 be denied when squeozed ootweoolhumb and lingers, 100 hard 10 be slic&<:l w~h a sharp knHe, and 

when Ihe $800 coal becomos lighl brown in color. 

Use Limitations 

Do not exce&d a maximum 012.0 lb. aVA lor combinod uses of PREpm per acre per year. 

BoU Opening: Do nollank mix PREpm brand Elhophon with a desiccanl if Ihe cotton is 10 be spindle harvostOO. 

Pre-COnd~ion for Defollalion: Do nollank mix PREpni wilh desiccants unless plant desiccallon is required. Do nol use a delolianl 

bolorolhere is sufficienl maluro unopened bolls 10 produce Ihe doslrGd yield (see Generallnformalion section on how 10 leS1 for boll 

malurily. • • 

WHEN TO HARVEST COTTON : ••••• 

00 nol harvesl colton soonGflhan 7 days after a Iroalmonl w~h PREPot brand Elhopoon. . ... • •••• 

• ••••• 

• •• • • 

Observe Ihelrea1Gd crop and harvosl when optimum boU opening has boon reached. Too early harvosl mighl roduco Ihe.full adVafllt9Jl ••• 

ollhetroalmonl and 100 lale II harv!)51 may resull in reduced quality and loss oIlInl which w~1 drop lrom the plant. •• ••• ... ... • •••• • • • 

• .. ..... • • • • •••• 

• ••••• • • .. • 

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.. • • .. • .. • .. • 

46 

/ 
Crop 

Directed Spray 

Application 

PREPni 

PInta/Acre 

1113 

1 113 - 2 213 

USE LIMITATIONS 

50-SO 

4O-SO 

~---------------------

TOBACCO 

(Flue-Cured Only) 

Use drop nozzlos. 

gpa at 35-40 

2 nozzlos 

th. 

SpecIfic Directions 

Treat only whon loaves remaining on 1h. stalk at. maturo. To ensure 

, 'oaves are maturo. test spray sevoral tobacco plants as 

i s&etlan -Proper TImo of Treatment· u •• tho IowlJr 

in a normally maturo crop whon oxperience Indicates that mInimum I 

in<:iucornont is requited. Uso tho higher talo when tho crop is heavy and has 

a tendency 10 be mot. rank or when lemperatures ate lower than normal. 

Always test spray to determine if the tobacco is mature onough to respond 

to Iroatment wijh PREpThI brand Elhephon, 

Apply over-the-top PREP""' brand Ethophon spray as a fine mist using thr.e 

nozzles {ono nozzle lips avO/' tho center of the plant. and on each 

so all loavos at. covered sImilar to the 

I 

00 not apply PREpni brand Ethophon to immaturoleavos as this can rosult in unsatislactory coloring, wolghllo$$ and reduced loat 

quality. 

Do not allow tho crop to ovor ripen in tho lkild after using PREpno brand Ethophon, sineo this may causo some reduction In yiold and 

quality. 

Do noltroat befor~ anticipated major storm which could prevent harvGst and result in crop loss. 

Do not apply PREpn.i brand Ethophon If rain i$ ox~&d withIn 4 hours. 

APPL1CATION TIMING 

SUCCGS$lul results with PREp1101 call lor troatmont when leaves are maturo, not ovat!y rank groan whon sprayed. To easily determine 

the proper lIeatment timing and tho number of laaves por stalk ready lor harvest, tost spray sevoral plants In more than one location in 

4E

0ach field aild OOseNo the response. Maturo leaves wU/ begin to yellow in 24 to 72 hours. Test leaves that fall to yellow In 72 hours aro 

matute and are not ready for PREpn. brand Ethephon treatmont. Wait a fow days to permit lurther natural maturing, then make 

another test spray or "maturity" check.. / 

..,.vhon you have confirmed tho numbor of Ioavos por pb.ntthat will color, you can determine tho numbor of acres to treat in order to lift 

Whebarn. 

Prepare your teS{ spray by mixing 000' teaspoon 01 PREpnl In t quart of water. Spray each test plan! with about 1 oz. of this mixture, 

covering allloavDS with a fino mist. PREpn. brand Ethophon wUl not color immature sprayed loaves. 

WHEN TO HARVEST 

All maturo, sprayocf leaves will begin to color within 24 to n hours after PAEPn. brand Ethophon application. The yellowing proco$S is 

weather dependont; cool weathor wid delay, while hot, sunny weather can speed up the procoss. Harvost traated tobacco when waves 

have reached the desired color intensity. 

Do not allow tobacco 10 become over ripe before starting harvest leal drop can occtJr when tobacco is ovor ripe and Iolt on the Slalk. 

If a number 01 the bottom leaves have yellowod at-the timo of treatmont, they should be harvestGd prior to spraying wfth PREpn. brand 

E • • thophon, : ••••• 

Wllh an over-the-top application, harvesting can commence 24 hours altar PREpru brand Ethephon appHcation depePdiN on ~.: 

conditions or to avoid over rips tobacco. Tobacco harvested 24 hours atter treatmen1 will require more time in the cotqrmt'hase of 1ho • 

curing process. .": •• : 

CURING PREp-t'M TREATED TOBACCO •• •• 

Curing procedures rue as much an art as a science and oach cure musl be judged on tho basis of tobacco cond~iog:i1lf4rVal betM$Tt· • 

treatmenl and harvesf, weathor and type of curing facility belore proscription temperalure and vontllalion Ichft4ulos cottrbb· 

estabUshed. To obtain maxImum quality, cam must be laken 10 observe and control tho curing process closely, e~ty during the 

late ~coJormg" and early "drying~ stages of tho leal. •• : •• : 

PREP'N brand Ethophon treated tobacco will have started tho coloring prootss when harvested, reducing the timlJ ~uir" in the ". 

coloring phase of curing. Treated tobacco should be dried faster. If tobacco leaves are groen or contain some groorfwNta'harveIlW:·: 

~ may be noceswy to color them for a low hours. If the leaves are completely yollow, temperature and ventHation must bo.ad!ustM lit" 

a mannor to dry the lobacco as last as possible w~hout scalding. Once the IGaf is dried (314 dry), you shouk! follow rfq,rgtaJ procedures 

lor curing. Since PREpnt brand Ethephon lreated loavos cure laster. treated and untreatGd loaves should not be cured togethor In tho 

samo bam. 

47 
LIMITED WARRANTY AND DISCLAIMER 

Tho manufacturer warrants (a) that this product conforms to tho chemical description on tho label; (b) thai this product is roasonabty lit 

for tho purposoo sat forth in tho dirOClions for use whon it is used In accordance with such directions; and (c) thai tho dirGCtions, 

warning and othor statements on this label are basad upon rasponslbte exports' ovaluatlon of reasonablo losts 01 oHoctivenoss, of 

toxicity to laboratory animais and to planls, and of residues on food crops and upon reports of floki oxperlonc:ct. Tosls have not bean 

made on all varieties or In all states or under all conditions. THE MANUFACTURER NEITHER MAKES NOR INTENDS. NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES. EXPRESS OR IMPLIED. AND IT 

EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANTIES OF MERCHANT-ABILITY OR FITNESS FOR A PARTICULAR 

PURPOSE. 

lHlS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND All lOSS OR 

DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE lABEl 

DIRECTIONS. WARNINGS OR CAUTIONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE lIABIUTY FOR ANY AND ALL CLAIMS, 

LOSSES, DAMAGES. OR INJURIES RESULTING fROM THE USE OR HANDlING OF nus PRODUCT, WHETHER OR NOT BASED IN 

CONTRACT. NEGLIGENCE. STRICT LIABILITY IN TORT OR OTHERWISE SHALL BE LIMITED. AT THE MANUFACTURER'S OPTION. 

TO REPLACEMENT OF. OR THE REPAYMENT OF THE PURCHASE PRICE FOR. THE OUANTITY OF PROOUCTWITH RESPECTTC 

WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHAlL MANUFACTURER OR SELlER BE LIABLE FOR SPECIAL. INDIRECT OR 

CONSEOUENTIAl DAMAGES RESUL TlNG FRCM THE USE OR HANDLING OF THIS PROOUCT . 

• 

onCE TO BUYER 

urchase of this product does not confOf' any rights under patients govGMing Ihls product or tho use thereof in countries outside of the 

_ Uniled States. 

IOEF and Guthion are r&glstered tradomarks of Bayer AG, GGrmany. 

2Dropp is a registered trademark of NOR·AM Chemical Company. 

lHarvade is a registered trademark of Uniroyal Company. 

4Malathion is a trademark; of American Cyanamid Company • 

• • 

RhOne·Poulonc Ag Company 

P.O. Box 120t4. 2 T.W. Alexander OriV8 

Research Triangle Park, North Carolina 2n09 

PREP Is Ihe trademark of RMne·Poulenc. 

FOLEX is a regislered trademark of RhOno-Poulonc . 

PREpN brand Ethophon for Cotton and Tobacco (PENDING) Submitted to/15f93. 

...... • • 

• ...... .... " . . . .... 

• • 

•••••• 

• 

• •• • .... • 

.. •• • •••• 

. . • .. .. •• 

48 

. ..... 

• 

• •••• 

• ... '. 

• . ..... 

• • 

•• 

" .... .. • .. • 
PI atlse: rca d I n$ t rue, l om; on lflvcn;c oro comp I I ot ng I arm. ,F,,;r.-, " OM'1 N'. 't. ,ji,- , , ", '" 

(A) Unitud Stolos , PIOlCc~o!) AI1t'nly r- Registration i(',:')' du·t,I;!Jr ,',\:,'l,tH ! & EPA Otlico 01 Pl)sticido PrcglO!1!5 \H75('~C) t=: Washing/OIi, DC 204(;0 Amendment 

Applloation for PestiddB: Other 1 "70 'i'; '- ,J '-"'", 

N!!!llbm 

!~G P~rk~)i " 3 ." 264 ' . , .. -~ -- I~ : 4. CcmpanylPloouc! (Nome) PM~ 12 _J";,,,,:; [1 Ht':;.~n~t . PREP"" brand ethephoJ1 for Cotton ilnd T, 

5 Name nnd Addlc5$ oi Appi,enn! (Inr;;lJd!71IP Ct'lfaj ! G. Ex!':: I!t 'd !1ClV\CN. :n -, wi:., l,{nA St:;C:iC" :':.i~;.;.- :--' 

Rhone-Poulcnc Ag Company t tbill). n:~ p!c,dlJ(:: h} S"'1'\:H 01 id(!n!;co! ,n f:.dni <):;,!i:w, aMi L".JH .'J ! 

2 T. II.. Alexander' Drive I 10 ! 

RTP, He 27709 1 i 

Fj)" !->.,' , , ----- . . -------,~-- ---------- ! 

$ 

o CI1C'O; illi!!,~ 15 A r!cwtlddl!!M Prcduc; , lam.; -,-- --, "- -- -< - - -_.--, - --,. 

~~ .. ~----~--~~-

1 II Ii - ------~--. - , . E~pi;Hl L-t'io-w 1 I "r; 'p.",:.:d u\.:c,:; '" f"<>:;n~e:o 

" ~ ... h; -N ( k 1",1 ;l,n"d_ -"'--.. -,,~,--,,-. -----,,- " --~ ----~ _._---

In fe·.pMW (0 Age<,cy l'lth)! cn;,'KI .. . 1 '" I ,~' ;'PF!,.:::;~,'.'n - ".' 

Hohlicm;()1! E~P!');!l tll/low ,- _. •.. ,- , ,,-,,;' ':",,!;k1 v..:'~';' 

- E>:planallon: U.::e mif!itiollal Ptlg()i~) il n4CVS::,1f~! \1"0, $l;{",\,(;n inn;! S(!c:w'; Ii ) 

Addition of retllrnable 110 ga 11 on cOlltainQr l:occr';;)endat ion to last approved EYA 1 abe 1 

Other contiliner sizes of 1, 5., 10, Clnd bulk s t i! 1 be used. 

,-

Section II! 

M.",I,I Thl. I VillI 

, , 'i I i Un;! , I "P,,",,) '''''''.01' " 

5] ::~. a YI>~ - Yi':$ il""!" 

~ No ~;i;;~ flo G~a,,:; 

~~;;"~~~kngC w(Jt 

No pm II 'Yes: r1) Pd' _ Pii.snr,c>, , con!"irWf P;lck<l:jo w:.11 O~hc' .c'_, 

• Cerliffcaffoll musf be , ",!:J'rt(r 

. I, ,------" I' L="ooolI"" .1 " I' fi'o('G~\I~~' C;i~';,l '~':"." u",', ,.'. , 

n L,b" II"'!, i E3' ' :1o" 'I' 'J , , " " "·o'~',' 

: G "'m", I, "',<I, ",,",II, "'''''" '0 P,~d,," i-i ~~;,.gi~"'d C=l U:,orL, ___ " --,-,----- . .. . . , " i1 1 ! .. " - , , , , ". " ,,' t", Ce," ,'d. ",w", " ""p, '<' -:;;;,0,'} , 

, 110m, I,l" ,10. ',,' (., _,.,..l!: tv,m C:;.:, 

l'latTen Davis Senio!" Registration )'l0..'lager 919-Sli9-2379 

CcrtiliC<lI!on , C·,,,, ",:","", 

I UHt,ty ma! tho r.![lh:ma:'\f11~ I have n1nu'J (II! !h,~ ;';'(0, ilod nl! J!1~1;:h:nDnl~ !1:c·f(·!j ,"10 ""'" ::1t';)1!;:)~_! lnd r;("m(ll )1& ;:";"~,,,,-,!d 

I ndmowloOgc lho! any knoWingly tulw or mi';i<},llJrrg S!,;l\c,r;en! may 1'-0 Pt'i1'~!.J)'i2 ;;y "'.0 0~ 'r:T"~:-;;L~'lJnt:or ISI",..,p~t!) 

ooth undol ;"Jpp!'(;"1hln Il'IN. 

- 2 i , I' "", 

/, (; j-- . 

, , , , 

-~ .. --- ". -.. - ! , , 0.1:" 

/Iarren A Davis 49 

PA eo,m 8570·1 i V,·,,', ." 'i" i '0 , 'P! , , i," ,- ,.-<', A;::,,, ,',1 .i C" 
• • 

• • 

RHONE-POULENC AG COMPANY 

ETH 93-28 

October 15 ,1993 

U. S. Environmental Protection Agency 

Office of Pesticide Program Document Processing Desk 

Room 266 A, Crystal Mall No.2 

1921 Jefferson lJavis Highway 

Arlington, Virginia 22202 

Attention: Ms. Cynthia Giles-Parker 

Product Manager (22) 

Fungicide Herbicide Branch 

Regislration Division (I-T7505C) 

Dear Ms. Parker: 

RE: PREP® Brand Elhephon for Colton and Tl)bacco 

EPA Reg. No. 264-418 

Appended arc three labels for Prep that have added a section fOf mini-bulk returnable 

containers. This is tile only change from the last EPA approval the wording for the rccydabl::> 

container has been approved previously by EPA for a number of our products including 

bromoxynil. We trust this minor dlange may be approved promptly as productiGTI for 1994: 

sales will begin by the end of the year . 

Since no data are being submitled or cited to support this label amendment we believe that an 

offer to pay data compensation should not be lIecc::.sary. An application for amended 

registration is appended to complete this submissiun. 

We apprcciilte your assistance. If you have any qu(,stions please contact me pro'llptly. 

Sincerely, 

'If // 

'Warren A. Davis 

Senior Registration Manager 

''0 HOx r/),4 2 l' .... ,~~[,·M !l),~ :COl;" 

fl(SfAFlCh'lKII;NOLl PAri". n'~ ;<;:./, 

19H1) S~<j·ZOO::r 

'Un..i1'ATlDNM. 1Hf:<. ~j'jW'fH 'l,'-,'~jiB ;,' I',:'LHW[~ ,\.\~ "(I' 

mTfftNATIC""Al O:SflWUl or--. <,Hl','::r:: '( Lc~. 1k~il< r; .l')JJ ,I:' l.r';:',"'8ill-j·W ~" 

50 
Pl<mfJ. fUd ltutructhms ."_f."", (A) . X Registration ,OPP' &EPA t~/;IlCide: _ Amendment 

= Other 197043 , " 

264-,//[( tEPC. i', 

0,.,,,,, o Restril;:/Od f 4, CompanylPrriduct {Namo) PM' 22 

PREP® brand ethephon for Cotton and 

I' !Add!",. 6, Review, In, " 

,'" ~9 Com~any t?!.(ii:-;"y produclls simUar 0; idenlical in composition and labeling 

2T. -Ii. DrlVe "0: 

RTP, NC 27709 

EPAAog, No, 

D Check if this 1$ a nowaddrou 

-

Explain boIow Rnal printed labels- in TOsponso 10 

Agoncy !cUM dal!id 

In rofipor1W to Agency kltror dntod r--

f- r--

"Me Too' AppIiCa~OfI, 

.. EXplain boIow< ~ I 0!Iw -explain below, 

I Use addioorml pnge(s) ilnawunry, (For wclion I and S&ericn II.) 

Addition of returnable 110 gallon container recommendation to last 

Other con~ainer sizes of 1, 5, 10, and bulk still be used. approved EPA label, 

III 

'Bo' 11", 

, I""" 2 ~' 51 v,,' ,-- Yos - Yes r:x:- ;;rubc 

X N. - N. ~ N. 

, Ne, par ~:v.",'. No, P"f 

• Certllkatlon must be "-, conroinu coommer 

I 

"Olabcl 110 (;:\!,:~'(ne~) i ' , ~!'"~ " '",,''''''' ". pn",,,, r= o <JmM, ) 

eon,"" , Nrune n .. ""~ ,~~'2;7'i' • 'J""'" 

Warren Davis Senior Registration Manager .. ,. 

• 

• 

,6 .. : .. 1 certify Ihn! tho 51t1lements I have m~ on this 101m nod all altaciunonltl thcr-eto flM 1fI.Ie. accumll) and oompicw. 

I ncknow!edge-Ihn! any knowingly fwoo or mil>~adinli atalefMfI! may be punblmblc by nne Of impriMmmIm! or • 

both undor appkabfo law • .. ::: 

I' j(/~ ;.) / b I' Ti"" 

• • .. 1:J ."LIe ~~. • • • • ••• 

(~:/: (' 

•••• • 

a: """( '; C :CC: 

... • • • . . •••• I' T ,pOO N """ 15 0"" 

Warren A. DaviS / 

!'i1 

'"",1'''', wnjro , tVA ' ,.-
PAPERWORK • REDUCTION ACT NOTICE and INSTRUCTIONS • 

INSTRUCTIONS: 1h1& form \$. to '* uud ter all applicatfCfl$ tor nw registration, end I,l$I: rer09istrlltioo, ~t. 

restbllliHlon, to applieatlOllll for notificat!QI"I:I!; fiMl printed tahetiflQ, reregistration, etc, 1>"1 order to pranss an 

awllcutioo (or a rwu Ngistratioo !il.tmitt«f on this font. the f611cwlno Nterhlt .. t IU;C~ the lIflPUcation: 

1. Certification with R~t to tftstlon of Pata (EPA Form a51O-29). Ilf not exempted by 40 erR '52~81 (b) (4)1; 

2. Coofidentlo\ 5t31:0$00t of fotmJla (8"A Fom M1O'4): 

3. fotmultltor's £x~tiCl'! StatCiMf!t (li'P" f-ONl'l asro·27); 

4. five cop!" r..f draft 1$001 Ins; 

5. lnrM coph!tI of any dolts sutnrtted;: 

6. Authorization letter where 4pPllcaole; 

7. Matrices ~en $ppl kable. 

Slb!I;u;oo Qf l&bellr:-g • labellf&f 4hould firlt be stbIIlned In Ute fom I)f draft l~l!I with all awlic«t{oruI for rwu 

rasistratiQ(l. Suel! draft t~t$ !64Y l:w In the foOll of t'r'f*J l4bd teat on 8.5 j( 11 Inch poptr ;'U' 4 mcckllp 'of the proposed 

l&bel. If ptcparoo Ill> fI ~k~, It ~houtd Iw cQO$troetecl io m.>dl e !illy at to feeH It,a@ ~tor. !n iIfI a,s x 11 ioch fi tJ:. 

Hoekup labels &igr;iflcantly Yna(ter thM 8.S )I; it theM. dloo!d ba lIJO'.J1ttd Of) 2.$ x 11 Inch paper for $}.tt:missl~. 

St;tajnioo of Data ~ Oata ,u\::ImlttOO !I'! li\JPpOft of thh- apptielttloo!!l.$t be $dimlttti4 10 M;ccrdam::tt with Pit Wotict &-). 

SPECIFIC INSTR!J!alQH~: r[c;>!;(t n;ad th1i! iNtrud:f\W1S tI!itoo below befon !;0q>leUns this <>pplicij,tIOfl. firtt 

ooteN!1lr.e the tY!X' of revlltfMi'w ~l;Ctlon, liM&O in ,Heck A, for wlidl yIJlJ life stbnltting thit applkllt!co. for 

applications t!bll!rted In c~ctfoo with Ml1w Ker!htrtltlon &ctiCO$, £«:t\oro I, !II, M'ld IV 1W$t ~ cWptetoo by the 

awl iccnt. For aWl kittlcm ~j tted !n c0VWttlon with ~ r&gigtretioo actiot'4;, rHub!iiss!ons, notificaticro. 

rerltgletratiorm, etc" Section:; 1:, fl, wd II! l!ll.mt be CM1plllted by the epptiCMlt. 

Sled, A " Ched: the apprcprlate c-ctlon for lilich yOO'!lfh $l.lbIlttlng thlf; form. 

SECTION I ~ thj¢ nrt{OtjOO nJtt i» ,~IQted. I)';' nppl f.:abte, fCf' lilt reg;t:tratIM ACtiooS. 

1. ~JPr't'dJct ~ - !nnert 'roo,. ~~. If «llII ho bEen tlnl~ by EPA. 11lh ~r may hav'.! l»M- lIuigrwd 

to yet.! as liI I.XH:)e f'c!i/ittr1l'nt." 11 di:Hdbutor. O?" n W'I IUtubll~h$IOOt. If yotit" pl"oaxt: 1$ resiu<\'red, \rzert the ~t 

Z. -. EM Pl"CIduet M&nager - If krmm, fill tn tht; I'l&M end PH nuwbe:r of the EPA Product HllMg.:f'. 

3. p~ cl_Hicotion - Specify the prope~ed c!u$iHctltioo of this pr....oocL 

4. ProriJct!tame - fMer the CG'lp\ete prodltt fWl\& of tM~ pesticide M it uHt llf'PtlK co the I~I. 1M flil'!\q I!mt bE 

sptt:itlc to this Pf'~t coli'. Ot$lltlltioo cf naw,r,; Is 11<:It: p!:rmltted ~ prOOJch Iif th/! 1Ii&f¢ c~ny. !kI not ir.::t~ 

ant brn ~ or,~ l!f'>It dHiSIWtl/UW. 

5 .... and ~ Gf AflpllcMt ~ The nwme of the firm or person 1II'1d ~e$11 sh6Wfl In YfJ<Jf" npplicilltlon 1$ tta ptnon or firm 

to whan the regiurllrion will be if;Su«i. If yoo nfC lK:tirq In bEMlf "f mother party, you wmt twit authorintion frO$! 

that party to act for them in registrAtion M4tters. Art $ppllc&nt not rt$idlng in the united StAtes must have W'I 

, 

&!.ltherlud "!IMt residing iN the Unit«:l Statoo to act fOf thell fn an registration matters. Thft f'IMII!' ~ c~letoj ffllIltinsl 

..,-kInas of weh an sgent nost l>CC~f this ¥plicotion. 

6. E>:pedlted IIICVINil - FlFAA slXtloo 3 (t) "3 (iI) prcvldH far e..:pedlted rw!cw of appifc;)tfcns fer reg\stratico, or ~ts 

to OKlsting registrations, that are 3fmllar or !~ticol to other pesticide pr~ts that ore currently registtred with 

the EPA. In enkr for yoor appticlltiCf"t to be eligible for ftXP'lIdited revieli, you I#.W;t provicfu w with th-: EPA IhtgistratlM 

Hulber G#'Id prcd.lct _ of the prGOvct )'i'A.I btlt!e\i"(! is similar to or idmtil:nl to your prodoct. The pro:iK:t _t be 

slmllor or identical 10 both fOllllUlatfon bOd 1aJ:::.eleci OO!!$. 

SECTION n - this $'ection .nJ&t be carpletoo for 1'111 tlW'iicatlO<"¢ ~!tted to amend the rtilistnltloo only of II currently 

reglstltNld pn:d.tet (~t), for tI (ftC\.blliS$\Ofl 10 rUponGe to on Agency letter, for fW)tificariQI'W to tM AswcY. (or lhe 

w.brn!s&fon of flool print«l IW"lHf1jJ, fer f>lfftglstntioo m'd for fI!'IY oth>lr actioo that p!!rtairm to iii !!IN£ifl", m-rgs!mt>l!rsQ 

~. This section is!l!U 12 !.m wed for II M>l I'It'fAkathm flU' r~htt.tlon. , 

1. SUbject of ~iscion - Check the "Wlkabl>l block Md provide tlH! ~ tetter date If awtopr]/lte. Provide a brief 

explG04tlOf'j of th~ purpQ§e(s) for the ~I$sjcn, s~h 4' ~th. addition of'f $it~, p¢@t or crop (&p¢Cify)~; ~~ thft 

cooHdentfpJ St¥Mmlt of fonwlfl by ••• "; Iirer~hUati«l lnblduiM"l g4mral label {lrvf$ic,--; of use dlreeti«w." Attaeh 

I separii"ti"'iMI':ff additional $p3CC Ill' ~ • 

••• ••• 

ZEtTlON l~l1Q.~lling iiind Cgntainer InfofrnatjJIDl· ,hi4 $-o/::t,o-< !aJtt b cc",,"otet('!j ttJ all "Wi!crJti«lt 

i~n«:l in 1: ttfoo with new re!li$trilitlm'l "I" &ppllctblt! _-.-:.4!.tnt~. 

L.Jlp¢ of P~if19 - Cum!; tht Gprf'ordatt:! bl0Cli: if 1<'13 f}f~£t.;d dU 1:.'1' f.$(kfod in ~h; 'M;,~ht0d ,.$(,,«)Irl$ typ;'15. 

1r.dkiH* ttt. !ifn of the fnrlhddml r.d:et-,;; &'d 11tWb¢f' t<1F rtU;1\ Ltnuiner. '~'Ud' of lW\~h: OmtaImr • lrdie.llte ,~ of contajrwr h uhir" VI?:fust Mltt b& N!ro;eluJ. 

:L·"MdtiM c-f.~t ~Mte - 5p$::ffy tht 0$t c0;'1hmtl\ 0f ~!l nUnl c<:mtuirwn it;!' YOU1 (>f0'.:iicL 

,_ &:f:m(s) .n-lg~Ji etmufner - s~dfy t/"j'f tWt CO\'\HY1f~ d "q rUil1\ i:01t!~lrnft- for ytAff tyf4xL 

~,."iWfon <If tJ:¢ Dffecti~ - lnd!cstt- ttli!~ to-:;;tbr. Y (he ';He Oir«;diYW- for '!Wi' prtXhKL 

.;, .• ~ in ~rd! l1:lbt1 11'; IJfiixM t<t p¢¢dOct H..a\("\B t1)" 0<,1:00 prodv:t !~\ IS attM:hA to ,,,,tojl tVlt'fit"lr. 

•• • 

S"tjpN 19.£~btact Point) - ;hl; SlKtkn ilLsr u (:"'pkrd t0r #It g,0ptk<lti<X$ f01" Pt'Ji$tratltm m:tiOO6, Le., 

Mll pr-'Oducts .egi'(l.ratlw, fl"!l-tA.m!$idOCl, "_-t&:J," r;):r~"!1qrlilt;or), t'tt. 

l·S. sclf-cxpt~~'Y. 

6. EPA Us .. tx'tly. 

52 
• (,I' RHONE-POULENC 

"-./ 

I 

I 

AHONE·POUlENC AG COMPANY 

ETH93-2B 

October 15 ,1993 

U. S. Environmental Protection Agency 

Office of Pesticide Program Document Processing Desk 

Room 266 A, Crystal Mall No.2 

1921 Jefferson Davis Highway 

Arlington, Virginia 22202 

Attention: Ms. Cynthia Giles-Parker 

Product Manager (22) 

Fungicide Herbicide Branch 

Registration Division (H750SC) 

Dear Ms. Parker: 

RE: PREP® Brand Ethephon For Cotton and Tobacco 

EPA Reg. No. 264-418 

Appended are three labels for Prep that have added a section for mini-bulk returnable 

containers. This is the only change from the last EPA approval the worcling for the recyclable 

container has been approved previously by EPA for a number of our products including 

bromoxynll. We trust this minor change may be approved promptly as production for 1994 

sales will begin by the end of the year. 

Since no data are being submitted or cited to support this label amendment we believe that an 

offer to pay data compensation should not be necessary. An application for amended 

registration is appended to complete this submission. 

We appreciate your assistance. If you have any questions please contact me promptly. 

• • •••••• 

Warren A. Davis • 

•••••• 

Senior Registra tion Manager 

PO HOX It"Jl,\ 2'W AU::;(I,r·.[;Cfl CiH \'r 

F!E%A!1CH 1PIM,GU' P,\[j>( 'i C ?;:VJ 

(Of!.!) S49-2[X>~ 

iNTERNAi:ONM ;UEXNt'f.j8U'l ;'N:JI';.'·f.j,\CY ,~rc \·1[- 'MERHAflO~,,\I_ O,SlR nUl!Ot, 'F! ,_ < 'r' r'.lB[R N~>;(!?T- ;1'-i,;',','CI1SA>, N'<" I', co 

••• • • • • • • •••• • • 

• ••••• 

• • .. • • 

•••••• . .... • • • ••••• • .. • • • • ••• • 

• ••••• • • • .. • .. • • • •••••• 0 ••• 

.. • .. • 

• • [xce/.lei'l~1i ''l fer fD-'_'T;3:1CF 

P'.de ,r. ,.;d '-0\ er':e, 1! 

53 
: 

• • 

• 

WITH PA'tA 

FEU 

SIG (DATA) 

FEU 

PI! 

HUH plln 

FEU 

SIG (DIITA) 

PI! 

• 

f ( 

'AlIT 'l'lIACI{ • 

APPLICATION 'OR ~ 

Init. Date 

NO pAn Init. Date 

FEU :1 /J!, Lii,)!y3 

'~I! '/ ' I'M 'c-' ~"," '/ ) 

REGULAR 

APPLICATION POR AMENDKENT 

In1t. Date 

NO DATA 

FEU 

PI! 

Init. Datto 

• Front End Proceasinq d.te .... in.d thi. application' quallt!.. tor tast track review ba •• d on reqiatrant. 

cIa!. of -•• -too". No .cr.an tor aUbatantial a1a11arity i. made by the Front End. 

, ! 

54 
, 

: 

• • 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

MARGARET CHERNY 

RHONE-POULENC AG COMPANY 

P.O. BOX 12014 

10/21/93 

RESEARCH TRIANGLE PARK NC 27709 

OffICE Of 

PREIIENTION, PESTICIDES "NO 

TOXIC SUBSTANCES 

PRODUCT NAME: PREP BRAND ETHEPHON FOR COTTON AND TOBACCO 

COMPANY NAME: RHONE-POULENC AG COMPANY 

OPP IDENTIFICATION NUMBER: 197043 

EPA REGISTRATION NUMBER: 264-418 

EPA RECEIPT DATE: 10/19/93 

SUBJECT: RECEIPT OF AMENDMENT 

DEAR REGISTRANT: 

The Office of Pesticide Programs has received your application 

for an amendment and it has passed an administrative screen for 

completeness. 

During the initial screen we determined that the application 

qualifies for fast track review. The package will now be forwarded 

to the Product Manager for review to determine its acceptability. 

If you have any questions} please contact C. Giles-Parker} 

Product Manager 22} at (703)-305-5540. 

sincerely I 

Front End -processing Staff 

Information Services Branch 

Program Management and Support Division 

RflcycledtRflcyclablo PIIr>\lId lUIllI Soy'Ctl!«. IIIi< M ~I>tt tll.1 

COIII~r>l -' 1_ so;:. l'e'o;:ycIM II\!« 

55 
, 

-~----~---

Picase road InSfructknut 

(A) ..,. ERDA UO;IM 

-0 M 

II, CompanylPfOOutl Number 264-418 

form. 

" DC ""in fRegistration 

Amendment 

Other 

188582 for Pesticide: t 

~Ori"I"~~~~iI ;=1 fc-; "' m 

r,:-::eo-m-".-",-="""":-:""-cq,,",-,,,.-:-) -----------fIP"'M~2.;--2~ .~-------- -~I 0 None 0 RoSIrK:lOO 

PREP brand cotton boll opener 

IS. Name and Addres5 01 ApplicMl (frwhJdo ZlPCodv) 

Rhone-Poulenc Ag Company P,O. Box 12014 

2 T. W. Alexander Drive 

RTP,.JIC, 27709 U Chock il /his it a new aridffJ!i$ 

ill 

16, 10 

(b)(i). my product 

to: 

EPA Reg. No. _____________ ~ 

Rnill printed labels in msponse 10 

Agoncy klltordated' _____________ _ 

'M!t Too' Awlie3tion. 

QIhCf' o)'plnli1 below, 

I pago(,) il n&COuary. {For $octiool and $(H:-tion II.) 

Notification: (PR Notice 93-3) labeling statement prohibiting application to water. 

I' 0 """" 

IN,,,,. 

Warren Davis Senior Registration 

NOTIPICATIOII ....... 

P£R PA 

_-

HOTJCa" 

M-no .-y / I 7~7' i <. 

'7 7 

• • ",,, . . ' :) 

• 

. -" 

I 

,;. 

I' 

I amity that tho statements j havo mJlld(} crt mis Iorm ar.d all I:lltllcilmeot3 thereto am 1;\.1(1. IlCOJrale and complete. 

I nckrn:Y-NiadgalhatMY knowmgly Intw 01 milleading slstemeot may be pun!!h4\b/o by line or imprilonmMlI or 

both Ul'!dct ... ppllcabla law, 

I' I' "', 

/"'"U/1'1 /J/l,. Seniot Registration Mana9~Y' 

I' T""", Nam. 15 Daro 

Warren Oavis April 23. 1993 

r:-I' 

,~'o' ... ,,"'"' Wh'" EPA Coo eopY y,now· 

- ~ ----

: .... 

• "::: 

"::. 

,," . 

.... 
PAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS 

PAPERWORK REDUCTION ACT NOTICE: PUblic reporting burden,for-this collection of fnfortration'b,'estimateci 

to aV(!r~ 0.8') hour per respon$t1", in.clu:Hng tfllC for rwf-owlng lMtructiO(I$} simrehino ext$tlng data sour(_, gathering aM 

mtl!intalnfno the tklto needed, M'\d cOI'Iptetlno art:i,re.rietling the cotltction of inf~tlon. "Send cOOJIIO(jts regarding the hurdIN'! 

estimate or any other aspect of this eoUtx:tlOO6f information. lnchiding Wiif:$tiOM fo.r n~duclng thh; burden, to Chief, 

InfonMtion Policy Sranch, p)o!·223. U.s. F.nvlror.ntat Protection AOWCY. ~01 "'StrMt, 'SW, llashfngton. DC 204~; ao;I to' the 

Office of [nforMtion ;l!'Id Rt'gVlatory ~ffllirs, Orflce M MMlOgMJl':flt and Budge:t. UOllihf09too. DC 20503, 

INSTRUCTIONS: This form is to bt used for ali I'ipPtJcatlons for ~ rq[stratlon. end we reregistration. Uler'ldnmt. 

resubfllsslcn, to 0pplicl,Iticos for notiflclltionil, flNt printed libeling, ror*9[&trotiOO, etc. tn order to procoss an 

ewUclitlon for a MW regil;tr(ltioo subriitted on this form, tla fo[tOWlrlO .terfal JW!ft l)C~ the application: ," 

1. Certification with Respect to Ciution of Dllta (EPA roNl8Sro~29). tlf I'lOt IIJl:tflJ,'Jted by 1j0 erR 152.8' (b) (4)); 

2. confidentIal StIIt~t of fOrl!JJla (EPA rom 8570-4); 

3. fcnwlator's EXaTptfoo Statl!tllWt (EPA rONl! 8S1tI·27>f 

4. five copics of draft [abeling; 

5. Three copies of any data ~uI:Jn!itted; 

6. Authorization tetter wherfl epplleable; 

7. Motricell. where app[ [cOO[e. 

Stmlsslon of labetlng ~ Labeling shou[d first be st.br1ftt«t In the fONl! of th'lIft iabel& with3Ht IIpplicQtfoo& for n«I 

registration. Sut:h draft labels IN!>.,! 00 in the form of t)'f»d lebiI[ tIIxt 00 8.5 x 11 in<:h paper or a _k~ of the prOfX$ed 

tabeL [f prepared &s a !!lOCkup, it shwld be COMtruettd In such a WIY tUI to fDeliltatll' storal}{! -in an 8.5 x 11 ineh file. 

HO-::KUp labels signlficant[y $MIter than 8.5 JI: 11 inches should be fIIOIXItM en 8.S x it inch p4PIIr for stbrlinioo. 

Sub.ission of Data ~ Data submitted in support of thIs app[lcatlon ~t be s~itted in accordan(fI with PR Motlce 36'5. 

SPECIfIC INSTRUCTIONS: Pleue reJXI the Im!roetforu; listed bEtow ~fore c.:;:q')lding this applictltien. first •. 

determine the tyPe ot registrntion ~tjon, listed In 'lock A, for which you ~re submitting this application. for 

l!ppttcatlons !u/:mittcd in com«:tlon with )Ie., Rlt9istratioo actions, Sffcti«l$ [, [ll. Mid [V I'mt M cilltfjleted by the 

tlppliclIDt. for app[ !cations 5ttmitted in cO!'1l'i¢Ctton with ~ r~lstrat[on aet[OM, resubmhsiOl"tS .. notlficatlot!$. 

rernglstratioos, (!otc., Stctions [, [I, and [V /lOst Iw 'Of!l)leted by tile applicllflt. 

stod: II ~ Check thE nwrcpritlte <'fet[on for uhicll yeo Grc: stbllittfng this form. 

SECTION 1- lhil; iI(!et[en m.J~t be Calpteted, " app[icable. for all registration &<:tiOM. 

1. CoItIpanyJP«dJct /ill.btu-- ~ [nsert your ~ 1fUIb:Ir, if one ha, be«! NS[jr,ed by EPA. l'hfs ~r lI'iIIy h.~ bun tllIslgned 

to you as €I ba~b~f clistdbl./tcr, or $ an e$tabll~t. [f your product is reg\$:terw, insert the Pr~t 

2. ~~t ~JI~Titi in tile MIM I!Od FfoI ~r of the EPA Product HaMGf!r. 

3. p~ tt~~/M ~ Y~'1ly the ~opoted cbulfictltion of th[§ ~t. 4. ProWct ~ - ~r:tru:'.;!l!.LS~lq~·,«pduct MM pf thi!! pKtfcfde a§ It ,ullt awear on the label. l'ne I'\iIIM rust be 

$p¢C[flc to this prodlJct"oofy. Dup[ [catfon of NlIM§ is net P\lOlIltted GIIIOfl9 prcd.kte- of the ,tIM cOOf'Mly. Do not iocllde 

1!>O"f brand 0/lI00 or c~!\XIny line dfligr.atlt.ns. 

5, Waoi:t end ~ of Apptlcoot • The I'Wlfm! of the f1m er perllon and :.ddre!!> ~ in ywr iIf'P[ication I§ th~ penl«i Qr f[11Il 

tl) mW! the rt'g1stratioo wi 11 !» i$4ooo. If ,'100 are M:til'l9 in behalf l>f IMOther party, you I!fJ&t eubflit authorization irMl 

that party to.ret for them in rllg!f:tration rMltterl!. An awl icent not residing in tho:! united Stlltes _t hl\Ve un 

authorhed 1I9lmt fj!-$idif>lj [0 the Unit«l' States to act for them in 1I11 rC5htrtlti'on motterl!. The NiI!\I:iI' al'ld c.:;:q')[ete ma[[ing 

address of such an agent I!I!J5t accOO'pal'iY this IIflPt [catioo. 

6. EXpedit!!d Revlw . F\fAA $Htfon 3 (cl 3- (8) pnw!d-ts for expedited fevllW of llpplic3tiQtl$ for registration. or ~t. 

to existing re~istraticnll, that are slm[lar or identical to other pestIcide pr¢dvcts that are c~rrcntty r09i~tered wlth_ 

the EPA. In order for ywr tipptication to 00 eifllibh:'for Il){p«lited revlw .. you rust provide \1$ with the EPA Registration 

JrI~r end product Il/WIe of the product you ootieve ilS similar to or identicaL to your rwoduct. The produet m..mt be 

simi tar or idwntical !n both formulation and t~ted uscs. 

SECIION II·!Ofhfs s«:tion _t 00 ~[Il'ted for all applications lIl-linltted to IlfflI!f'ld the re!Jistratfon onLy of III currently '~f;t...-ed Pf'lX:I&t (A~tJ, for a rU-lltFdssfon [n rli~(! to M1 AQ«IGy letter, for not[ficaticns to the Agency. for tim 

:l..IIlnts(lon 04 'lMl.prlnted tab40[ lng, f(}f reregistr!Jt1co and for any other action that pertains to I) "§P!Kilfh:.- ru·rMiOJer!XI 

.IK!iI.Wtl, TII~ slU'tion is!'&1!2. £t una fer a flfl.r'I!f9[iCl'ltion fer ;"g:fs'tr.tion. 

4~-si.bject: "f ..miSSion ~ Clled-: th01r IIfPlicwle b[cek and providt the AgMty tetter eate if f>WtOflriate, Provide a bl-ief 

"exp[4rnltiClloof"tJle pJrpe!.a(s} tor the'$l!brniui'on, such.u nthe adtIition of ft site, pest or crop (specify}": '".mend the .·~HdimttlJ(.·l1lJtroomt of forw[:. by ..... ; "reregistration !Qiplorv*('pneral lat rll'Vlsioo of \.I$e dlreetfOO$." Attru:h 

'''.CliXlrnte JX!iC''if additlM3[ Splice is Meded. .... . 

t5IION . In·fracKaging '. and Cpotainer Information) - This SactionllUu bo c~leted for all flw[icati~ \-Vfltted in cJttne<:tlon with ow reulstratlco or .wl icllble ~ts • • 111 lW -of P~llIG ~ Cfwd:; the awroprhte block If Y-OIJI'" pr-cd.Ict }flU be pod:&ged in tht indicated I*-kugj ll9 types • • ·w,cate !1iq,'Ue of the ind[vid<.utt ped:etsc lind' t"!Ufixtr per retail cOl'ltainer. ~·T~ of .,tail.CMteiMf" ~ Indicate type i)f contillner in \KlIch proOOct wlll be mrht«l. 

3. Loudon ~ofk:t.ccntmt$ ~ Sp«ify the net contents of aU retall'c:ontalmrs for y«rr product. 

4. sbe{s) -ot·k\Ln COOt4joor - S~[fy th11- net ContMts of alt retail -containers for your proOOct. 

5. Location of JJe.e Dfreetions ~ Indicate the [oetitirm of thll' use direeti<rn: for your proc.k.x:t. 

6, ~ in which tabel illl IIffi~ed to pn!d.to.:t - Indlcatl? the method Pf"¢dJet lMI ill attK-hed to retail conttllr.er. 

SECTION IV (Contact Point) • Thh Section I'rOSt be c<*pletlld fov a[1 appticatiCOf; for lteg[lItration actions, i.e., I')¢Il prod.icts regfstration, r(fll!Jtmfssioo, "1I>t·too," rere-gi!:tratfon, I?tc. 

1·5. Sel f~exph;natory. 

6. EPA lJt:;e onty. 

57 
l 

LABEL INFORMATION PAGE 

PREP'"M brand Ethephon for Cotton and Tobacco 

MASTER LABEL 

Routing: 

Product Development 

Product Manager 

State Registrations 

.egistration Manager 

General label revisions: 

• Revised the cotton tank mixture u/d and added to General Information section the paragraph (Tank 

mixtures with Defoliants and Insecticides) . 

• Notification 6/9/93 - revised wetlands statement. 

Rate changes for the following: 

CA restrictions: 

4l»rinting Restrictions: 

• ••• 

• 

•••• 

• • • •• • 

• 

• • •••• •• 

• 

.... . • •••• · 

• 

• • • 

• • • 

•••• 

• • 

• • • •• •• 

58 

...... 

• • • 

• • 

•••••• 

• • •• 

••••• 

• • 

••••• 

• 

• ••••• 

• • 

• • 

•••••• 

• • • • • • 
NOTIPICATIOII ... ....... _""VIIlW J - ... _ .... 3 

11.11'11. 7f I 2-/ If 

ETHEPHON FOR COTTON AND TOBACCO 

For Commercial Use Or AgrIcultural Use Only. Not For Resldant/al Use 

ACTIVE INGREDIENT: Elhephon (2·Chloroelhyl) phosphonic acid· ........................................................ 55.4% 

INEfn I~IGRIEDIIE.NTS: ...............................•...•....................•.............•.................................................... 44.6% 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

PRECAUCION At USUARJO: SI usled no !eo ingles, no uso oslO producto hasts quo la informacion on la ollquota !8 have side oxplicado 

II 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EYES: Hold eyolids open and flush w~h a gentle stroam of wator for all03s1 15 minutos. Get medical attontion. preferably an 

ophthalmologist 

IF ON SKIN: Immodiatoly wash skin with plenty of soap and wator. Romovo contaminatod clOlhing and shoos. Wash clothing 

separaloly beforo rOUS8. 

IF SWALLOWED: Do not induce vomiting. Promptly drink a largo quantity of milk, egg wh~os, golatln solution or a those are not 

availablo, drink large quantities of water. Avoid alcohol. Call a physician immediately. 

IF INHALED: Remove victim to Iresh air. If not breathing, give artificial respiration. Administer oxygen if nocossary. Got medical 

attention. 

PRECAUTIONARY STATEMENTS 

DANGER 

.a/iAZARDS TO HUMANS AND DOMESTIC ANIMALS ~ROSIVE. CauSOS eye and skin damago. May be fatal if absorbed through sR.'tn. Harmful /I swallowed or lnhalOO. Avoid broathing 

spray mist. Do not got in eyos. on skin or on clothing. Wear luu longth trousers, long sleeved shirt. protective gloves, and goggles or 

face shield when handling. Chango to clean work clothes dally. Wash thoroughly with soap and wator after handling and boforo eating, 

or smoking, Remove and wash contaminated clothing bolore reO$e. Koop away from domostic animals. 

NOTE TO PHystCIAN 

There is no spaciHc antidote. All treatment should be based on observed signs and symptoms at distress In the patient OVerexposure 

10 materials other than this product may have occurred. 

Victims 01 severe oYGrexposuro, by inhalation, should be kept under medical observalion lor up to 72 hours for delayed onset 01 

pulmonary &demn. In a victim 01 ovor-oxpcsufO by ingestion, carelul gastric lavage is required due to the pcssibitlfy of .stomach or 

esophageal p&rioration. This malorial is an acid, but uso of alkalino substancos to neutralize It Is contralndicatod. .:. . ..... •••• • •• ENVIRONMENTAL HAZARDS •••• : • • 

<\ ••••• For terrestrial uses, do not apply directly to water, to areas where surface wator Is present or to Intonlda! areas below tho moan hl9/t • 

wator mark Do not contaminate water when disposing 01 equipment washwaters. •••• 

• ••••• • •••• Do not contaminate water used for irrigation or domestic purposes. 

USE PRECAUTIONS 

Do not apply PREpllI brand Ethephon through any type of irrigation system. 

• • • 

•••• • • 

•••• 

• 

• •• 

••••• 

• 

•••••• 

• • •• 

Avoid spray drift to n&amy crops as this product will Cause modifications In plant growth. 

Do not plant anothor crop wahin 30 days aftor treatment. 

Plant injury or reduced yimpS~ft' result'·:··: 

Mix only tho amount 01 spray you expect to use each day. Do not allow mixed solution to stand overnight. 

• • 

• •• .. .' 

59 

• ••• 
DIRECTIONS FOR USE 

It Is a violation of Fodoral Law to UBO this product In a manner Ineonslstent with fts labeling. 

Road entire lab.1 before using this product. 

REENTRY STATEMENT 

Mixers, lOaders and applicators must wear a fult faco shield, long trouSGrs, long 5100vOO shirt. gloves and boots to avoid as much skin 

and eya contact as possible. 

Do not Ontor troated flolds within 24 hours after application unless protective clothing is worn. 

contamlnat& wator, food, or fead by storago or disposal. 

or contonts have spilled, follow all precautions indlcatod abov& and clean up immediatoly. Beforo cleaning up, 

trousers, long sleeved shirt. protectfvo glovos. and gogglos or faco shield. Soak up spftf with absorbent modia such 

or other suitable material and dispose of waste at an approved waste disposal facility. 

hazardous. Improper disposal of OXCO$$ pestlcido, spray mixture, or rinsato Is a violation of Federal law. 

of by use according to label instructions, contact your State Pesticide or Environmental Control 

roplesontative at tho nearest EPA Regional Offico for guidance. 

GENERAL INFORMATION 

COTTON 

I . 

and of in a sanitary 

A foliar spray of PREP'll( brand Ethephon will acoolorate opening of mature un0p6nGd cotton bolls and enhance defoliation which can 

result In earlier harvest with an increased recoverable yield. PREpm brand Ethephon treatment on cotton allows incroased efficioncy 

lrom a once-over harvest. 

TOBACCO (FLUE~CUREO): A foliar spray ot PREpno brand Ethephon promotes early, uniform "yellowlng~ of mature tobacco. 

PREpDI reduces curing time, allowing more officiont use of curing barn space, and increased control over hal/vost schedules, 

SPRAY PREPARATION 

Add 112 to 314 01 the required amount of wator to tho spray tank. Start agitation. Add the raquirGd smounl of PREpt'IoI brand Elhephon, 

and the remaining amount 01 water, Prepare only as much spray solution as can be used on the day of mixing, 00 not allow spray 

sofulion to stand ovornight Do nol spill the concentrated PfodUd on spray oquipmenl, or any airplane parts, 

ANY SPfLl.S SHOULD BE RINSED IMMEDIATELYWfTH PLENlYOF WATER . 

• 

5& of a nurse tank is highly recommended fOf Qyoiding possible spills of conconl!afGd formulation on spray equipment or any airplane 

arts. 

TANK MIXTURES WlTH DEFOLIANTS AND INSECTICIDES 

PREP'"" brand Ethepi10n is compatible with OEF', FOLEX~\ DraW. Harvade3• Methyl Parathion, Guthion1, and Malathion", PREp'Il.1 

may b. applied In sequence or as a tank mixture (DO NOT TANK MIX WITH DESICCANTS IF COTrON IS TO BE SPtNDLE 

HARVESTED). Follow all applicable us. precautions and rato por acre rocommendatlons on labels of products applied as tank mlX1Ures 

or In sequence with PREP N brand Ethephon. In somo casas slight reduction In boll opening response has been observed when tank 

mixes with defoliants wore used. 

Good agitation In the spray tank is essential and a tank mixture should not be allowod to stand without agitation for mOfO than 5 to 10 

minutes. Road and obslHVe all appropriate !abal \l$e directions and precautions for the defoliants and insectickfes u\4:.1. 

• NOTE: Undo; CGrtain conditions, fank mbduro$ 01 PREpnI brand Ethophon with desiccants containing sodium cl1klrttl could!··:·: 

rosulr in the formafion ot hypochlorous acids which on heating will emit toxic chloride fumes. • •••• • • ... EQUIPMENT CLEANlNG • • ••••• • .. • 

BoC4uso of the acidic nature of this ploduCl, probnged exposure to spray deposit will damage acrylic plastics; fJl.(tJIln paj~!i ... lJfld 

metals. • •• : ••• 

Rinse thoroughly with a detergent and wator all exposod acrylic plastic-type materials (e.g., aircraft windshields), "'d' l>1dntoo surfa.os 

wllhln an hour after oxposure to spray deposits, .... • ..... 

• •• At t,he end of .ach day, rinse thorou.ghly wilh a detergent and watar all the metal parts 01 tho aircralt and t~e '\sJlOciated $pt;ty 

eqUipment oxposoo to the spray deposits. ••• •••••• •••• • • 

• • 

• .. • • ~~ 

60 

•• •• 
COnON 

USE 

PREpm 

8011 Opener" 

PREpDI + 

FOLEX· 

Oefollant Tank 

Mix 

Dropp2 

Dafollant Tank 

Mix 

Pr.~Condltlon.r 

for Defoliation 

.. ~ .... ~ - .. -.-----.-.... - .. -~ 

EXPECTED 

CONDITIONS 

HoI: and dry OO-F or 

higher 

Dry and 75 to 8O'"F 

Cool but above 65~F 

Rank cott'::n 

High soil moisture 

0< 

High lortiflty lovol 

0' 

Rank cotton 

High soil moisture 

High fertility Iov91 

Rank cotton 

1113 

2 

22/3 

113 

113 

Hot, dry. above aO°F 2J3 

Cool, above ssoF 1 113 

or 

Rank cotton 

PREp1Y 

RATE 

I LBS A.I. 

\.0 

1.S 

2.0 

0.25 

0.25 

O.S 

.1.0 

6 

4 

24 

24 

12 

6 

SPRAY VOLUME 

(GalsJA) 

APPLICATION 

TIMING 

15 - 50 

15- 50 

10-50 

15-50 

AIr" 

Apply when tho number ?f 

mature unopanod bolls, is 

sufficient to produco '~t~~ 2 - 5 desired crop. 880 below"uI 

tost 01 boll maturity, 

Treatment uniformly .~."''' bolls 710 14 days earlier. 

5· to Apply 4 to 7 days. Pfio~ to 

PREptloE boll . 

:3 -10 

2-5 

application. To be us.od.~ 

a soq.u~~:!!1 tr.atmon~IW~; not In ",,:,,,,,,of PREpTU """ 

Apply 4 to 7 days prior to 

defoUant. Enhance.s-:op 

crop defoliation i 

deterioration of bottom_~,~~ and allows lor 

·Pretreatment With DelolIants Prior to PREPTM Boll Openfng Treatment 

H the cotton is overly rank or laying down in the middles and good spray coverage 01 the bolls with PREPTW Is difficult, a pretreatment 

with defoliants will be useful to improve boll covGrage with PREpn.!. Use dosage rates of PREPW brand Ethephon recommendod for 00" 

opening. Read and ob$orve all, appropriate label use directions and precautions for the defoliant used. 

uln Califomla and Arizona use a volume of no l&ss than 5 gallons par acre for aerial applications. _oIl Maturity 

A bo11 is mature when it 1$ too hard to bo dented when squ9(lZod betwerm thumb and fingers. too hard to be slicod with a sharp knite, and 

when the Hod coat bocomos light brown In color. 

Use Llmltat Ions 

Do not exceod a maximum 012.0 lb. altA for combinod uses of PREpN per acre per year. 

Boll Opening: Do not tank mix PAEp1'l4 brand Ethophon with a desiccant if the cotton is to be spindle harvested. 

Pro-Condition for Defoliation: Do not lank mix PREpDI with desiccants unless plant desiccation Is required. Do nol use a defoliant 

bofore thoro is sullieiGnt mature unopened bolls to produce the desired yIeld (seo GonoraJ Inlormation section on hpw to test for boli 

maturity. .:. 

WHEN TO HARVEST COnON •••• : •• :.: 

• •• • • 

Do not harvost cotton soonor than 7 days after a troatmont with PREP"' brand Ethephon. ••• •••••• 

Observe the troaled crop and harvest whon optimum boll opening has beon reached. Too oarl), harvest might reduce die lull oov ... ;t&O; 

01 the treatment and too late a harvast may rasuH in reduced quality and lo$s 01 lint which will drop lrom thQ plant. : ••• :. • •••• • • • ... " 

•••• • • • 

•••• • ••••• • • • • • 

• •• • • • ..... , •••• • • 

• • • • • • 

• • • 

•• .. 

61 
--------~~-~----.~~~ 

PREp'nA 

Crop Situation Plnt./Acr. 

Dir&C1ed Spray 

Application 

Over-The-Top 

Application 

1113 

t11"3-2213 

USE LfMITATIONS 

50~50 

TOBACCO 

(Flue-Cured Only) 

Use drop nozzles, 

gpa al 35~40 

2 nozzl~ ... ~or !·!",';,o"e:M 

'he 

Spaclflc Dlractlons. 

or OC spray tips doslgned to apply 50 

at tractor spoed 01 2·3 mph. 

side of the row dropped low 

rIpened and harvested, 

a dirocted spray, be sure to harvast II 

Treat only when loaves remaining on the stalk ate maturo. To 

remaining leavas ara mature, test spray several tobacco 

described under tho sectlon ·Proper Time of Treatment.· Use the ~:~;;!::~ I 

a normally mature crop when experience Indicates that minimum 

inducemont is raquirod, Use the higher rate when the crop is heavy and 

a tendency to be more rank or when temperatures am lower than normal. 

Always tost spray to detormine If the tobacco is mature enough to respond 

to treatment w~h PRE?n.! brand Ethephon. 

ov,,,.,h,.,op PREP~ brand Ett,epho"spray as a fine mist using throe 

'he plant, and ono 00 oach . to the I 

Do not apply PREPTJ.! brand Ethophon to Immature loavos as this can rosult in unsatisfactory coloring, wolght loss and roducod leaf 

quality. 

Do not allow the crop to over ripen in the fi&ld aftar using PREprw brand Ethephon. since this may cause some reduction in yiold and 

quality. 

Do not treat bGfor. anticipated major slorm which could prevent harvest and rosult in crop loss, 

Do not apply PREpni brand Elhephon if rain is expected within 4 hours. 

APPLICATION TIMING 

Succ&sslul results wHh PREpni call for treatmont when loaves are maturo, not overly rank green when sprayed. To oasUy dotermino 

tho proper treatmontliming and the number of leaves per stalk roady for harvest, test spray several plants In more than one location In 

each lield and observe the response, Mature leaves will bogin to yellow In 24 to 72 hours. Test klaves that faUto yellow in 72 hours are 

not matum and are not ready for PREpn.! brand Ethephon treatment. Wait a lew days to porm~ further natural maturing, then maks 

anolher test spray or -maturity· chock . 

.rthen you have conlirmad the numbor at loaves per plant that will color, you can determine the number of acres to troat in order to lill 

~ebarn. 

Prepare your toat spray by mixing ono teaspoon 01 PREpn.! in t quart of water, Spray each tost plant with about 1 oz. of this mixture, 

covering aU loaVQs with a fino mist. PREp!M brand Ethophon will not color immature sprayed leaves, 

WHEN TO HARVEST 

AU mature, sprayod loaves will begin to color within 24 to 72 hours after PREp-n.! brand EthGphon application. Tho yellowing process is 

weathor dopendem; cool weather will delay, while hot. sunny weather can speed up the process. HaMlst troated tobacco when leaves 

have reached the deslrod color intensity. 

Do not allow tobacro to become over ripe bofore starting harvest. leaj drop can ooeur when tobacco is over ripe and left on the stalk. 

H a numbar of tho bottom leavos have yollowed at tho time oltroatment, they should be hruvesled prior to spraying wi!. PREpn.! brand 

Ethephon, • • ••••• 

•••• • •• With an over-the·top application, harvesting can commence 24 hours aftor PREpn.! brand Ethophon application d.ptndipg on fleathef 

conditions or to avoid over ripa tobacco, Tobacco harvBstoo 24 hours after treatment will requite more time in tho oolO!ing pha~1l'1t 

curing process. •• 

• • CURING PREPN TREATED TOBACCO :..... ..: .... 

Curing pmcedurGs are as much an art as a science and each cure must to JUdged on the basis of tobacco cond~k'!rI. JQterval btlMII'n 

troatment and harvest. woather and typo of curing facility bofore prescription temperature and ventilatio"If~,dules can 'be 

establlshed. To obtain maximum quality, care must be taken to observo and control the curing procen closely, espqcially du":~t,,< 

late ~coloring· and early ·drying~ stages of the leaf. • _. • •• PREpm brand Ethephon troatod tobacco wDl havo started the coloring piOCO$$ when harvested, redUCing the time ~r~ in thl·:·-: 

colollng phll88 of curing. Treated tobacco should be driGd faster. II tobacco loaves are green or contaIn somo groeO whqrl harv6ltett~ 

it may bo nocessary to color them for a few hours. II tho loaves are rompletoly yenow, temperalure and vanlilation "'l.~tt adiustod in 

a manner to dry the tobacco as fast as possible without scalding. Once the leaf is dried (3/4 dry), you should follow normal procedures 

for curing. Since pREP"" brand Ethephon treated leaves cure faster, treated and untreated loaves should not be cured together in the 

same bam. 

62 

, 
.. _--------------------_ .. _ .. ~ --.--..... ~ 

LIMITED WARRANTY AND DISCLAIMER 

Tho manufacturer warrants (a) that this product conforms to the chemical d6scrlption on tho label; (b) that this product is reasonably lit 

for tho purposes sot forth In tho dirocllons for use whon it is used In accordance with such dlrGCtions; and (c) that the directions, 

waming and other statemonts on this label are based upon rosponslblo experts' evaluation of reasonable tests of effoctivonoss, of 

toxicity to laboratory animals and to plants. and of reslduoa on food crops and upon reports of floklexporience. Tests havo not beon 

made on aU vanalles Of in all stalGs Of under aU conditions. THE MANUFACTURER NEITHER MAKES NOR INTENDS, NOR DOES rr 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE, ANY OTHER WARRANTIES, EXPRESS OR IMPLIED, AND IT 

EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANTIES OF MERCHANT-ABILllY OR FIlNESS FOR A PARTICULAR 

PURPOSE, 

THIS WARRANlY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND ALL LOSS OR 

DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE LABEL 

DIRECTIONS, WARNINGS OR CAlITJONS. 

BUYER'S EXClUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, 

LOSSES, DAMAGES, OR INJURIES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, WHETIlER OR NOT BASED IN 

CONTRACT, NEGlIGENCE, STRICT LIABILITY IN TORT OR OTHERWISE SHALl BE LIMITED, ATTHE MANUFACTURER'S OPTION, 

TO REPLACEMENT OF, OR THE REPAYMENT OF THE PURCHASE PRICE FOR, THE QUANTITY OF PROOUCTWITH RESPECTTO 

WHICH DAMAGES ARE CLAIMEO. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, INDIRECT OR 

CONSEOUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT. 

NOTICE TO BUYER 

Purchaso of this product doas not confor any rights under pationts govorning this product or tho usa theronf in countries outsido altho 

United Statos . 

• OEF and Guthion aro registered IradGlllarks of Bayer AG, Germany. 

20ropp is II regi$torod tradornark of NOR·AM Chemical Company. 

3Harvade is a registered tradomark 01 Uniroyal Company. 

4Malaihion is a tradomarkof American Cyanamid Company, 

• 

RhOne-Pouienc Ag Company 

P.O. Box 1201.1.. 2 T.W. Aloxandor Orive 

Research Triangle Park, North Carolina 27709 

PREP is the 1rademark of Rh6ne-Pouklnc. 

FQLEX is a registered trademark of Rhbno·Poulonc. 

PREpnt brand Elhophon for Cotton and Tobacco (MASTER) NotiJicallon 619/93. 

... • 

• ..... 

• .. • • • 

• 

.. • • ..... • 

•••• 

• • •••• 

• 

• .. • • • •••• 

• • • .. • .. • 

63 

•••••• • • • • • 

•••••• 

• .. • 

••••• • • ••••• 

• . ...... 

• .. • 

• ••••• 

.. • .. • 
• 

• 

Mr. Warren A. Davis 

Rhone-Poulenc Ag company 

P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, NC 27709 

Dear Mr. Davis: 

Subject: Skin Irritation study (MRID # 428727-01) 

PREP Ethephon Cotton Boll Opener ~~ 

EPA Registration No. 264-418 , ~ Your Submission Dated August 5, 19~ 

This will acknowledge receipt of the subject study. vIe are 

not reviewing it at this time since the summary of the data 

indicates that this study t>lill not change the toxicity category of 

the subject product. 

Sincerely yours, 

/5/ 

cynthia Giles-Parker 

Product Hanger (22) 

Fungicide Herbicide Branch 

Registration Division (H7505C) 

64 
-ntis ~ One copy of the '(I'PC di.a.gnosis .and 

one of the aMOQted ~i.bl.i.ogeaphy are prG1t.:tde3 for ~ £lles~ 

Lhe ppC It.as .already oaUed <out the. subcd:t:te.r"$ eopi.~ 'Of tlJe. 

t:QO <lOC'll:ll:lents~ 

• 

This is .a pE...~ll'y .acc~t.ed/::<!j~t:......""-d scl=ission_ _'\ ccpy of ::..':;~ .?~ 

" ~iagno$i.s w aud. ·Qf tile. an.'"'lO't2tcii hiDll.ogn.phy (if oappliccllleJ :are 

provi,d.e.d_ fer Yc:.J.F fUu_ ;,. se.cond. copy is prcvi<led for ;:tour us<:: in 

corresponding vita""!. 'tE.l~ ~~ ::--!:::::ritte:::"_ 

-. 

( ,"; ,,'. 

" 

• 

.' 

. . , 

, , 

! 

~~ j 

" 'I .:', 

'\ !, 

, 

.' 

;. . ! 

65 
• 

• 

U.S. ENVIRONMENTAL PROTECTION AGENCY 

Office of Pesticide programs 

RHONE POULENC AG CO. 

P.O. BOX 12014 

2 T.W. ALEXANDER DRIVE 

RESEARCH TRI. PARK, Ne 27709 

Report of Analysis for Compliance with PR Notice 86-5 

Thank you for your transmittal of 08/06/93. Our staff 

AUG \ I 1993 

has completed a preliminary analysis of the material. The results are 

provided as follows: 

Your submittal was found to be in full compliance with 

the standards for submission of data contained in PR 

Notice 86-5. A copy of your bibliography is enclosed, 

annotated with Master Record lOts (MRIDs) assigned to 

each document submitted. Please use these numbers in 

all future references to these documents. Thank you for 

your cooperation. If you have any questions concerning 

this data submission, please raise them with the 

cognizant Product Manager, to whom the data have been 

released . 

66 
~ RHONE-POULENC 

• 

RHONE·POULENC AG COMPANY 

ETH 93-21 

August 5 ,1993 

U. S. Environmental Protection Agency 

Office of Pesticide Program Document Processing Desk 

Room 266 A, Crystal Mall No.2 

1921 Jefferson Davis Highway 

Arlington, Virginia 22202 

Attention; Ms. Cynthia Giles-Parker 

Product Manager (22) 

Fungicide Herbicide Branch 

Registration Division (H750SC) 

Dear Ms. Parker: 

RE: PREP® Brand Ethephon Cotton Boll Opener 

EPA Reg. No. 264-418 

428727- 1'> cj) 

Appended are 3 copies of a recently completed dermal inilation study for PREP®. The results 

indicate that PREP® is a category II dermal irritant. This data should be made part of the file 

for PREP and an MRlD number assigned for future reference. If you have any questions 

please contact me. 

• 

Sincerely, 

.w~AJ)awA. 

Warren A. Davis 

Senior Registration Manager 

POBOX 1201".21'" ALD.ANO(R i::AI\lF 

R(SfARCH TR!ANGl£ PARK. nc ?l un 

(919)542-2000 

INTEANAT!ONAt. tELEX NUMBER ~9983lB- AN$','.,[I,u;,cK IJ>C flTP 

Im(RNAnOl'JN DISWllBUilON SER'.'IC"$lllfx NUI.1GU' 49VJ$77- M.$' .... I;R?J,¢I\ APe IDS 

. . 

,., , 

, 

., . . , . 

" , " , . , , " '" 

.. , 

." , 

Exceflence II') Performance 

Pride ill Achlevemonl 

67 
• 

• 

Rhone~Poulenc Ag Company 

TRANSMITTAL BIBLIOGRAPHY 

1. Douds, D. July 13, 1993. A preliminary Skin Irritation Study in Rabbits with PREP brand 

Ethephon Cotton BoH Opener, Conducted by Springborn Laboratories, Inc. 41 pages . 

. .. 

, '" 

. • < < 

• < « < 

68 
- - - - --- - ---- -- ---- -" -- -- -" -, -- -- -- ------- " -- ---------

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

Mr. Warren A. Davis 

Senior Registration Manager 

Rhone-Poulenc Ag company 

P.O. Box 12014 

2 T.lL Alexander Drive 

OfFICE or 

I'REVENTION. ffsnCIOES 

ANO TOXIC suaSTANCES 

Research Triangle Park, NC 27709 

Subject: Alternate Confidential statements of Formulation 

Prep® Brand plant Regulator 

EPA Reg. No. 264-418 

Your Letter Dated 01/30/93 

Dear Mr. Davis: 

According to our records, the source product (EPA Reg. No. 

264-276) for the basic formulation of Prep® Brand Plant Regulator 

(EPA Reg. No. 264-418) was canceled on 01/22/91. The source 

product used for the alternate formulation is EPA Reg. No. 264-

511. Before the alternate formulation can be accepted, the 

source product of the basic formulation must be corrected. 

Sincerely yours, 

-nthia Giles-Parker 

Product Manager (22) 

Fungicide-Herbicide Branch 

Registration Division (H7505C) 

.. !:l1.:;'[,.~... ................... .......... ............................... ............................. ............... ................................................................... . SURNAME. or/J;,ki 1. kv"";' .......................................................................... , ..................................................................................................... ' ................. DAT6 

EPA Fo,m 1320·1A 11/90) FILE c;opy 

69 
--.. --.~-.-.. 

, 

• 

• 

TO: 

PROM: 

THRU: 

PRODUcr CHEMISTRY 

PM e?';{ 

I. Ill.s-h" 

CHEMICAL:_-_____ _ 

REG. NO: ,;Ue1-'1Af' 

ALE SYMBOL: ___ _ 

REVIEW fOR END USE PRODUcrS 

PRODUcr NAMES: 4,. ;>k"J. j(7"'J ,,!. J. .. 

For e. +fo '1 

~ NOS. ___________________________________ _ 

Food U.e _____________ _ Non Food Use __________ _ 

Inens cleared: c ( ) d () e ( ) yes () no () 

lnens List I ( ) Other ( ) 

Please provide the requested infonnation for the following checked items: 

1. [J SubmJt the product specific product chemistI)' data for your product. { I if 

submJtted earlier, provide ~ Nurnber(s). {' Your product is not sufficiently 

similar to the product your referenced. 

2. In reference to the Confidential Statement of Fonnula (CSF), pi.... provide the 

(ollowing: 

[J a) pH of product at a specified water dilution. 

(1 b) Density of product. 

( J c) Flash point of product. 

[1 d) F1ash point of product with propellent as per item #6(q) or item #5(c). 
3. 

.2· 

(J f) The upper and lower ce!tilled limits based on the pure active ingredients 

rather than the teChnical or concentrate, 

[) g) The upper and lower ce!tilled limits of the individually added inerts. 

(I h) 

[J i) 

(J j) 

Based on the cwrent CSF dated, __ -", ___ ,-_' your product wUl not meet the 

label claim for the active ingredient. Please revise the label or the CSF so tl1lI1 the 

infonnation agrees. 

4. Provide the chemlcal identify of all components. the percentage cOmp05lllon. CAS 

Registry Number. and Material Safety Oat. Sheet (two copies) for the following 

compounds: 

L 

2. 

3. 

4. 

5. 

The supplier may contact BPA diIectly refe"mcing the Pile Symbol of BPA 

Registration Number in their response. For dyes. provide the color indea and CAS 

Registry Numbers for all components. For perfumes and flavorings. provided for each 

componeru in the mix"",,: the chemical name. CAS Registry Number. and the 

percentage or range in percentage in the mixnm:. Certify that flavors are non·food 

type. The Confidential information submitted by the suppliers is kept confidential 

under FlFRA Section 10. 

5. In the proposed labeling. provide the following information: 

[J a) Update the label Storage and Pesticide and Comainer Disposal Statements 

in accordance with [ ] PR Notice 84-1 for non~aerosol containers for houses 

and institutional uaes of [ J PR Notice 83-3 for all other we •. 

71 

• 

• 
• 

• 

-3-

[J b) Add the heading PHYSICAL OR CHEMICAL HAZARDS to the label and 

the appropriate statement per 40 CFR l56.10(h)(2)(iii). 

[J c) Under the heading PHYSICAL OR CHEMICAL HAZARDS, list the product 

as extremely Flammable (because your product contains flammable 

propellents). 

(] d) Provide that the solvent does not have insecticidal acuvlty, it should be 

removed from the ingredient statement active ingredient listing and the 

percentage added to the inert ingredients. If the solvent has insecticidal 

.properties. provide the EPA Registration Number. 

[J eJ Add, footnote to the inen ingredients indicating: Contains 

[J f) Since your data matrix does not provide a &electrical breakdown voltage, you 

must add the following statement to the physical or Chemical Hazards 

heading; 

Do not use this product in or on electrical equipment due to the 

possibility of shock .hazard. 

[J g) The terms active ingredient(s) and inen ingredients should be in the same 

type size, be aligned to the same margin and he equally prominent. 

[J h) 

[J i) 

6. In reterence to the product specific data requirements, provide the following 

information: 

[1 a) Statement of Composition: A complete description of the manufacturing 

fonnulation process. Describe equipment used, mixing time, temperature, 

pressure, etc. 

[J b) Discussion of Formation of Uniotentiona1 Ingredients: A brief description of 

impurities formed during the manufacturing/formulation process, in packaging 

or during storage. If you do not expect any impuritics during these stages. 

please so state. 

[J c) Cenification of Limits: Upper and lower limits or each active and 

indivtdually added inen component. 

72 

*Inert ingredient information may be entitled to confidential treatment*
[J d) Analytical Method: Provide the methods used to analyze for the active 

ingredients or a full reference for a published method or MRlD Number(s) 

(J e) Color: In common terms. 

[] 0 Physical State: e.g., solid. liquid, pressurized liquid, etc. 

(] g) Odor: In common terms 

[J h) Density: e.g., Ibs/gallon for liquids or lbs/cu.ft for solids. 

[J i) Ph: Provide pH of product or pH of a specified water dilution. 

[1 j) Oxidizing or Reducing Action: Note these characteristics, if any. 

[J k) Explodability: Note these characteristics, if any. 

[1 1) Viscosity: Can be expressed in centipoise or cenristoke. 

[J m) Miscibility: Note these characteristics if product is an emulsifiable Iiqujd and 

mixed with oil. 

[J n) Corrosion Charo:teristic.s: This information can be noted during the storage 

stability study. 

[1 0) 

[1 p) 

Dielectric Breakdown Voltage: For products used near electrical equipment. 

Storage Stability: The fonnulated product inust be analyzed for its acctve 

ingredients at time zero and during one yeat of stonage, The stonage abeuld 

be at warehouse conditions of temperature and humidity and stored in the 

product's cornmerciaJ package. Note: Por the storage stability study, you 

may not reference the data on source product concentrate you are using to 

fonnulate your product. 

[J q) Flamrnabi1ity: Flash point/Harne extension. The Hash point reported exceeds 

the one expected for this product. Pl.... check and resubmit. Misn=s 

tna!l<eted under pressure, including those conraining hydrocarboos, are subject 

in their entirety to tests indicated in 40 CPR Section l56.JO(hX2)(ili) of the 

maxlpacl:age. Note that Hash points for pressurized liquid from the contain<r 

[J If any of the items are not applicable, write N.A. and explain ressons are specified 

under chemistry data requirements footnotes. See 40 CPR Pan 158. 

73 

• 

• 
• 

• 

-5-

7. [J The following is the regulatory slatus of the men ingredients Wlder 40 CFR 

180.1001 for for the exemption of the requirement of a tolerance. 

8. Other 

Note 10 PM: Inter-office use only 

SUMMARY ATIACHED 

74 
..... 

41-1 

'1-. 

6:-J 

62-1 

u-:: 

U-l 

• u-:: 

u-, 

U-. 

U-S 

'3-' 

'3·1 

'3-' 

u-, 

0-10 

U-lJ. 

u-12 

U-l.l 

• <53-14 

u-u 

IJ-U, 

U-17 

u-u 

U-lSI 

'3-20 

U-21 

TABU 1: StlIIIIlU\Y 011' PRODUCT CllJlllISTIlY DATA Rl!:QOIIUlllllNTS 

....... II ...... i_ n-ProdIoR :r .... tity UI4 ~it.i.ea. (-IoenuS'.1.55 • "', l6::, ,.. . "" '1","","':1;. !"'-1:11:1' , puoh."",,_ ot : ... q-r..u .... u 

t-•• "tll'1:i .. " "I !;t&rt1.c. I-t&t_L.h 1 x.u,,..t.,,t.ul,!oq Pre ..... 

PI.C" •• 1.:" ~f rG~ti~n "t lAp .... .:.t, •• 

Ikrt.. U-AII&.I.p!. .... c.ru.tJ._t:.t... oL I'rodIIcrt 

__ U 

( • 0CI"Ill..» • 1"10. l'75 , 110) 

I'r.l.i.Jl.ulary ""'.ll"U 'Of I'.,,,duel;. $.-ph. 

c.rt,li ... tLoD ot I.:qr.d..I._t Lia.tt .• 

ADAlytJ. .... l K001:h...,u t .. VUlt C~1U'" t.1a.I.t. 

...... ~ ,.t-ft..,.1<MJ. .... ca...L....J. c:a....:_boIIUti_ (4oa'1ll.58 .LtG) 

<0"' • 

Pb.pri-.l st.d .• 

.... 

HIoJ.taq 'oat 

1Ioil..Ln9 '01.llt 

O-OUil;.y, • ...u. o-..ity, ~. n .. <l>: .... Ul' 

Sollihility 

V .. ,1: ... ...,. 

D.t...a.o_",-t"'- eo-t.aat 

OftaAol/kt,u 'utiU_ eo..tlilliu,t 

, p. 

,tabUit 

O~oiU.u.v or .....iaf' A.Gt:;I.oIil 

rl.-.bUitr 

"" 

ftClnt'<l .t. .... Ll,U,,. 

Vu_.ttf 

NU.u.LUty 

Co~"'" c:2t.u.R_~ti". 

Oi~i .. ~ 'lohttp 

... - ,\oDOopt .... 1. 

______________________ __ 

" - 'I'd ....... 

IU. - 141: .\c>Pll-.ble 

EX: ~ DIIt • .;.~ 

''''';:':'0" IIMd' ____________________ _ 

0.1:., ________________________ ___ 

75 
DP BARCODE: D~88188 

CASE: 003396 DATA PACKAGE RECORD DATE: 02/17/93 

SUBMISSION: S435392 BEAN SHEET page 1 of 1 

* * * CASE/SUBMISSION INFORMATION * * * 

CASE TYPE: REGISTRATION 

CHEMICALS: 099801 Ethephon 

ACTION: 345 TECH-FORMULA CHANGE AMND 

10': 000264-00418 PREP PLANT REGULATOR 

COMPANY: 000264 RHONE-POULENC AG COMPANY 

PRODUCT MANAGER: 22 CYNTHIA GILES-PARKER 

PM TEAM REVIEWER: CLARENCE LEWIS 

RECEIVED DATE: 02/09/93 DUE OUT DATE: 

FOR COTTON 

703-305-5540 

703-305-6117 

05/10/93 

* * * DATA PACKAGE INFORMATION * * * 

DP BARCODE: 188188 EXPEDITE: N DATE SENT: 02/17/93 

.... EMICAL: 099801 Ethephon 

TYPE: 001 Submission Related Data Package 

ADMIN DUE DATE: 04/03/93 CSF: Y 

ASSIGNED TO DATE IN OAT!: OUT 

DIV : RD / / / / 

BRAN: RSB / / / / 

SECT: PCRS / / / / 

REVR : / / / / 

CONTR: / / / / 

* * * DATA REVIEW INSTRUCTIONS * * * 

ROOM: CM2 

ROOM: CM2 

DATE RET.: 

LABEL: Y 

Attached for your review and comment is Rhone-Poulenc's 

letter of 1/30/93 & alternate CSF dated 2/1/93. 

* * * ADDITIONAL DATA PACKAGES FOR THIS SUBMISSION * * * 

• DP BC BRANCH/SECTION DATE OUT DUE BACK INS CSF LABEL 

55.4000% 

/ 

229 

261 

/ 

76 
• 

; ,. 

ETI I 'iJ,/ 

JilHtn,y:'O, 1903 

tJ. S. EnvimHnlt'nld! FrOlC'Cliun Agen'T 

c ;1" ,1l'(: (1 r p ,'(;:,il(lU2' .. , l'rogr\,lrn " I" A)nUllcl11 " 1 rt)n:SS!()!-_~ 'l" k':ir.. 

\{uorn 26(; A, Crys(at lvi.lll ~ro. 2 

U2l Jc{[u:::;Ot1 D,,'ll;'; l"-1iglw,-'.1Y 

,'\riii)gtOH, Vi((":inL1222Ul 

/\.Ue!dinn: Cynthia Gilt:S~!';-Hkcr 

_. 1',.,'"j' , 'I \,f- '1-~" ,,' (')')) " I, p,d «,_->'-.; "_~,, 

;\In ',k'Ik liddt' Unl)ch 

:'~-j'ru;h D:j ; ';;111:.1 rL{!ii R(',~~\,!:did' 

rT;\ [{in >!n, :Y)--l·-ii'? '-' -

('I'f))!k pi,)n{ l(j":,~HL}i.uf 

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AUTJ-lOI1IlE ANY AGE'lf (J11 REPRESENTATi'JE Ttl M;';.J{E, Any OTHEH V,'AnFl:\NnG:~1. FXPALSS "H !UPLi;:!), p.Jm n 

EXPHESSLY EXCLUDES /iJ'iD mSCL].IMS ILL [MP! If:O '//.'\;-;R;\N11ES OF }AERC!lANT-AfJIUTY Ofi FlrNE:~< ron II ?AfnlCULAr: 

PUfiPOSE. 

nl18 VJ!IRR,'\ilTY nOES NOT fXTEl'1O TO, AND ThE !?-ljYLR SI !I,n GE SOl ELY 1,'{ESf-ONSl8LE FOFl. t,!'IV AND ,,'i1.L tOSS OF 

DAMAGE WHiCH n.ESUJ.TS r.:!101,1 'fHG u;;E OF Tr~\S PRODUCT iiI Ar:,Y LiI\Nt;f.EI':; VIHiCH :3 !NCONSISTENT \'111 H TH:;;: Li\8H 

OiRECTiONS, w(,r:)glGS en C,"·UTiONS. 

GUVEfTS EXCUJ.' tVE Fli:L~i::lW AND MM1UFACTUGEn'$ OF! ;-.,HLEFf5 EXCL!.JSIV2 I.INlItflY for; AN'{ AND ;\!,L CUIMS 

LOSSES, DAV;\GF" I,}R IPJIJF;H':S P,ESULTH{G FflCM THE U!2E on HANDUliJ' c;~ lH!S PRODUCT, WHt::T!';EFi 0B r,;GT P;\SLD 11\ 

CONTRACT, Nc(;l)':~;:i1CE, ~rm:GT UAC;:: iTI In Tom f)R:On·jE~wnSE $1 ;:\LL He li:AITED, AT !Hi.: M!;N!WACTUl1i:C;-S OPTION 

,0 HEPL/I.CEL\[NT(,;~, en "!HE ilEFAYi'!,i. ~rfOF THE PunCH.AS::: PFH(;E ron, 'Ill!: CUAN fIrr \~>F PF\ODUC r \hll'H r:"::5i"rCTTC 

'NHICH DP,r,Jft(;(S N it: CUIt/O), iN flO ,:V':;rlT SHALL M;\f";,![7AGTUHLH OR :;;~I LEJ1 W'-: I,IABlE FOH SFEC!AI , ijJtijRJ:(~r OF 

'.Xtc':CUENTltIL f)A!.~AGL;S nrSliLJ iNC i"ri{)!'5 TnF usc: {.'n I~ANGUNG OFTH!S ;-';~0DUCr. 

NOTICE TO BU'{[:n 

P'Hci;~9} oj Jh'5 P'00W;1 6. , ; no, c," liM ron'} l'0hts '1'~(bl p'1~'2nki ~<:V<'/fii:;] this 0!L<iuc; O( ,i1o I;!;e 11:\;:,,·')1 in CYmlrie:; o,y"do ()i tl!G 

lJoil,}{j $b1,::; 

p;jJi1,>;\;IJ~:~"I; Gc ,n:";;,'/ 

PO. [>;:r. 12m 1, L'l.,', /'.:,-<",',J"" 8:;w 

fIG>·' • ";1 Ttl/, F,<~. 1;,;,:i1 Ca".': .':1 277;;) 

82 
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.~ ( iIIl' RHONE-POULENC \,~ on %' 

• 

RHONE.POULENC AG COMPANY 

Eth 93-13 

April 13, 1993 

U. S. Envirorunental Protection Agency 

Office of Pesticide Program Document Processing Desk 

Room 266 A, Crystal Mall No.2 

1921 Jefferson Davis Highway 

Arlington, Virginia 22202 

Attention: Ms. Cynthia Giles-Parker 

Product Manager (22) 

Fungicide Herbicide Branch 

Registration Division (H7505C) 

RE: Your Approval dated April 5, 1993 

PREP Ethephon Cotton Boll Opener 

EPA Reg No. 264-418 

• I 

Dear Ms. Parker 1£;:::::-~~'"'-"" 

As requested we are submitting one copy f finallabelinj!.for PREP Cotton Boll Opener. 

We appreciate your assistance in approving . ~endment in time for 1993 sales . 

• 

Sincerely, 

~~/f'. /:bc';" 

Warren A. Davis 

Senior Registra tion Manager 

"oaeX)?,;::!4 ?'wH;:)IL,F"J' ,i; 

n::S£AR~h mlAhGU': pAr;\', tJ : .';uJ 

(9:[1) f:~9-;:())r, 

I~ TlF!'i/.1"i01,;,\L 1 r1 L~ ~.U/;·E:·C; .t,q,Jj,',' _"''''',,/,c,,L'/~_v ,,''"c. ;j" i' 

'Hj;::F.tiA~'C·~_~"r;l,~Tjl'G\ r; ,C,I. c;nN ( ; :, Y'!..f\ U.J.'H':" ,1'Yi')'!: -"'I':I,HS;,-" ,, __ , :~ 

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Fxceiicnce in·Pc-riormi1::~;e 

83 
LABEL INFORMATION PAGE 

PREpTM brand Ethephon for Cotton and Tobacco 

MASTER LABEL 

Routing: 

Product Development 

Product Manager 

State Registrations 

• Registration Manager 

• 

General label revisions: 

• Revised the cotton tank mixture u/d and added to General Information section the paragraph (Tank 

mixtures with Defoliants and Insecticides). 

Rate changes for the following: 

CA restrictions: 

Printing Restrictions: 

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84 
ETHEPHON FOR COTTON AND TOBACCO 

For Commercial Use Or Agricultural Use Only. Not For Residential Use 

ACTIVE INGREDIENT: Elhephon (2-Chloroethyl) phosphonic acid' ." ..................................................... 55.4% 

INERT INGREDIENTS: ...........................•....•.......................................................................................... 44.6% 

"ThiS prOduct contains 6 pounds elhephon per gallon, 

EPA Reg. No. 264~418 EPA Est. No. 264~PA-01 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

PRECAUCION At. USUARlO: Sl us!od no 100 inglo$, no usa 6sl0 produClo hasta quo la informacion on ta otiquota 10 haya sido oxplicado 

, . 

usos t 

• 188 :;~';4·:2'O:~,9: licensQ is glantod to use this in countries other than tho for any 

• 

usa not contemplatod by this liability for palent infringoment may rosuh from use or sale of this product outside tho United 

Statas. 

• 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EYES: Hold eyolids op<ln and flush w~h a gentle straam 01 water tor at teast 15 minutes. Get medical attantion, proterably an 

ophthatmologist 

IF ON SKIN: Immediatety wash skin with ptenty 01 soap and wat0r. Remove contaminatod clothing and shoos. Wash clothing 

separately boloro rGU$o. 

IF SWAUOWED: 00 not induCQ vomitIng. Promptly drink a targo quantity 01 milk. egg whites, gotatin solulion or il these are not 

availabhl. drink large quantities 01 water. Avoid alcohol. Call a physician immediately. 

IF INHALED: Remove victim to Iresh air. H not breathing, give artificial respiration. Administer oxygen if neCQssary. Got modicat 

atlention. 

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

CORROSIVE. Causes O1e and $kin damago. May be latal if absorbGd through skin. Harmlulll swallowod or inhaled. Avoid breathing 

spray mist 00 not got in eyos, on skin or on dothing. Wear full length trous(lrs, long sleovod shirt, protective gloves, and goggtos or 

lace shioid when handling. Change to clean work dothes daily. Wash thotoughly with soap and water aftor handflng and beforo eating, 

or smoking. Removo and wash contamInated clothing belore reuse. Koep away from domestic animals. 

NOTE TO PHYSICIAN 

Thoro is no $p&Cifk: antidote. AU treatment shoutd be based on observed signs and symptoms of distress in tho patient Ovoro:.:posure 

to materiats other than this product may have OCCUlTed. 

Victims of sovero OVGrexposura, by inhalation, should be kopt undor m~ical observation lor up to 72 hours for detayod onset ot 

pulmonaf)' edoma. In a victim 01 ovar-oxprniuro by ingestion, catolul gastric lavage is required due to the possibility of stomach or 

esophageal perforation. ThIs material is an. acid, but use 01 alkaline substances to neutralize it is contraindicated, 

ENVIRONMENTAL HAZARDS •••• • Do not apply diroot/y to water. to areas whero surface water is present or to intertidat areas betow the1"~ ~igh w4Mtnark. 

contaminate water whon disposing 01 equipmont washwators. • •• • • • 

Do not contaminate water usod lor irrigation or domestic purposes. • ••••• 

USE PRECAUTIONS 

• • 

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• • • ••••• • 

• ••• • .. •• . Do not apply PREPTl4 brand Ethephon through any typo of irrigation system. •• • 

00 00' 

Avoid spray drift to nearby crops as this prodUCl will causa modifications in plant growth. 

00 not plant another crop within 30 days altor treatment. 

Planl injuJ)fMfd!:lucod wald;will rosult. 

Mix only the amount of spray you expect to usa each day. Do not allow mi:.:ed sotution to stand overnight. 

NOT REVIEIlED 

In Aoool'don •• with PR Notice 82-2, 

BeIIe4 OIl Draft Labeling Dated ;/. ,,' " 

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85 ~---~~~ ... -~- ~ 
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DIRECTIONS FOR USE 

It Is a vIolation of Fodoral law to ua. this product In a mannof InconsIstent with Its labeling. 

Road antira labol bofot. using this product. 

REENTRY STATEMENT 

Mixers, loaders and applicators must woar a luU face shield, lang trouSGrs, long sloovOO shin, glovos and boots to avoid as much skin 

and eyo contact as possible. 

Do not enter treatod fields within 24 hours aftor application unloss protective clofhing is worn. 

Do not contaminate walsr, load, or food by storago or disposal. 

If container is brokon oroontonts have spillad. follow an procautions indicatod above and ctoan up immodiatoty. 80loro doaning up, 

'"II I<,,~th trousers, long sleoved shirt. protective gIoV8S. and gogglos or face shiotd. Soak up spill with absorbont modia such 

la ... nd" •• uth orothor suitablo malarial and disposo 01 waste at an approved waste disposal facility. 

PESTiCIDE DtSPO$Al 

Pesticido wastes are acutely hazardous. Impropordlsposalol excess pesticide, spray mixturo. or rinsate is a violation of Foderal law, 

wastG. cannot be disposod 01 by uso accordillg fO tabol instructions. contact your StOlto Posticide or Environmental Control 

j~~~:;;,~~,tt:h;~e Hazardous Waslo reptesontativo al tho neOlre!t EPA Regional Oflico lor guidance. 

i Then ollor for Ii i , 

GENERAL INFORMATION 

COTTON 

t il 

an<j dlop''''' 01 in a sanital)' 

A totiar spray 01 PREpn.r brand Ethepnon will 8CCiIloralo opening 01 maturo unopened collon bolls and enhance dolotialion which can 

rosolt In oartior harvest with an incro4sod rocoverablG yield. PAEpn! brand Ethophon treatmont on cotton allowsiocroasod oltlcioncy 

from 4 once-over harves!. 

TOBACCO (FlUe-CURED): A loliar spray of PAEpn.r brand Ethophon promotes early, uniform 8yollowing8 of mature tobacco. 

PREPN roducQS curing time, allowing moro officiont use 01 curing barn spaca, and incroased conlrol ovor harvost schedules. 

SPRAY PREPARATiON 

Add t/2 to 314 of the roquirGd amount of wotor to tho spray tank. Start agitation. Add the required amount 01 PAEprw brand Ethophon, 

and the romaining amount of wator. Propare only as much spray solution as can bo usod on the day 01 mixing, Do not allow spray 

solution to stand overnight. 00 not spilt the concentrated product on $pray equipmont, or any airplane paris. 

ANY SPilLS SHOULD BERINSED IMMEDIATELYWfTH PLENTY OFWATER 

Use 01 a nurse tank is highly rocommendod for avoiding possible spitls 01 concentrated formulation on spray equipment or any airplane 

parts. 

TANK MIXTURES WITH DEFOLIANTS AND INSECTICIDES 

PREprw brand Ethephon is compatible with OEF1, FOLEX*', DroW, Harvado3• Methyl Parathion. GUlhion r, and Malathion~. PREPlM 

may b. appliod in soquenco or as a tank mixture (DO NOT TANK MIX WITH DESICCANTS IF COnON IS TO BE SPINDLE 

HARVESTED). Follow an applicablo use precal1fions and rate por acro recommendations on !abols 01 products applied as tank mlxturos 

or in soquenco with PREP tLI brand Ethophon, In soma cases slight roouction in boll oponing rosponse has beon observed when tank 

mixos with deloliants were uslKf. 

Good agitation in the spray tank is essential and a tank mixture should nol be allowed to stand without agitation lor more than 5 to to 

minutes. Read and obslUVe all appropriate labot use directions and procalltions for tho defoliants and Insecticides used. 

NOTE: Undor CGrtain conditions, fank mIxtures of PREpw brand Efhaphon with desiccants containing sodium chlorate could 

result in the lormation of hypochlorous acids which on heating witt emit toxic chloride lumos. • ••• 

EaUfPMENT CLEANING ...... ..:. • •• 

Because of lhe acidic nature 01 this product, prolonged exposure to spray depoSI! will damage a1:rylrc ~Ia$tics. clrtain paints, and 

metals. •••••• : ••• :. " . Rinse thoroughly with a datergant and water aU exposed acrytic plastic-typa materials (e.g., aircralt wirtq,sJlfotds). ~.Qainted surfaces 

within an hour after exposure to spray deposits. ., •• • .. ' : 

At the end of oach day, rinso thoroughty with a detergent and water all the metal parts of the ai~rad and tho aSSOciated spray 

equipment exposed to the spray deposits. ••••• .,. 

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86 
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cortON 

USE 

PREP1\( 

Bol/ OpenerPREpm + 

FOLEXCI 

Oefollanl Tank 

Mix 

u;;.r Dropp2 

oofollant Tank 

Mix 

Pr.-Condltloner 

for DefoUation 

EXPECTED 

CONDITIONS 

Hot and dry SOGF Of 

hIgher 

Dry and 7510 SOGF 

Cool but abovo 65°F 

or 

! Rook conon 

High soil rnojsJuro 

or 

High lertiJity Jevel 

or 

. Rank conon 

High soil moisturo 

High fortility love' 

Rank cotton 

1 1/3 

2 

22/3 

1/3 

1/3 

Hot, dry, above 80°F 2J3 

Cool, abovo 65GF I V3 

or 

Rank cotton 

PREP'!)ot 

RATE 

ONE 

GALLON 

PREP~ 

I LBS A.I. Acr •• 

1.0 

1.5 

2.0 

0.25 

0.25 

0.5 

1.0 

5 

4 

3 

24 

24 

12 

6 

SPRAY VOLUME 

(Gals/A) 

Air" 

15·50 2-5 

15 -50 5· 10 

to -SO 

15 ·50 2 -5 

APPLICATION 

TiMING 

Apply when Iho number 0/ 

rna/ur. unopened bolls is 

sullicient to produco Ihe 

dosired crop. See below lor 

lost of boll maturlty. 

Troatment uniformly opons 

bol/a 710 14 days owlier. 

Apply 4 10 7 days prio,.:~ 

deloHant. Enhances ~Ul' 

crop deloliatlon I 

deterioration 01 bot1om_:;:c:~ and al/ows lor earlier 

·Pretreatment With Defoliants prior to PREP"" Boll Opening Treatment 

litho cotton is overly rank or laying down in the middle. and good spray covorago 01 the bolls with PREpnt is dillicult. a pretreatmont 

with deloHants will be useful to Improve boll coverage with PAEpnI. Use dosago rates 01 PREpm brand Ethephon rocommandod for boll 

opening. Road and ohsoNa aU appropriate label use diroctions and precautions lor the defoliant used. 

··In CaUfornia and Arizona use a volume 01 no loss than 5 gallons per acro for aerial applications. 

Boll Maturity 

A ban is maturo when it is too hard to be dented when squoozed botween thumb and tingers. too hard to be sliced with a sharp knife, and 

when the $God coat becomes light brown in color. 

use Limitations 

00 not axcoed a maximum 012.0 lb. aliA lor combined uses ot PAEpnr pGr acre par year. 

BoU Opening: Do not tank mix PREpm brand Ethephcn with a desiccant if the collon is to bo spindle harvested, 

Pro..condition tor DoloUatien: Do not tank mix PREpnt with dos.icc;:mts unless plant desiccation is required. Do not usa a doloHant 

helorethere is suHiciont mature unopenod bails to produco the desired yield (see General Information section on how to test lor boR 

maturity. 

WHEN TO HARVEST COTTON 

Do not harvest cotton sOOnG{ than 7 days attor a treatment with PREpm brand Ethophon. • ••• 

Observe tho troated crop and harvosl whon optimum bell opening has boGn roached. Too early hzweJlto"'!9ht retl"H.tho tun advantage 

01 the treatment and too lato a haNest may result In reduced quality and loss of lint which win drop lKJmlh.plant • • • 

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• 

PREpTW 

Crop Situation Pinta/Acre 

Directed Spray 

Application 

OVer-The-Top 

Application 

USE LIMITATIONS 

11/3 

t tl3-22rJ 

so40-60 

tOBAcco 

(Flue-Cured Only) 

Speclllc D"octlon& 

Us. drop naulas. Choose TG or OC spray tips designed to apply 50 - 60 

at 35-40 psi and at tractor speed of 2·3 mph. Use 2"'0""." P''' row;ona on each side of tho rowdroppod low enough to dirQct 

tho the laavo$ to be ripened and harVested. Thorough spray 

euenllal. Wifh a directed spray. be sure to harvest aU loaves 

Troat only when loaves remaining on the stalk; are mature. To ensu(O 

romainlng loavas are mature, test spray sevoral tobacco plants as 

described under the section ~Proper Time of Trealment. ~ Use the Iowor rate 

in a normally mature crop whon experience indieatos that minimum riptlning 

inducoment Is required. Use the higher rate wOOn tho crop is heavy and has 

a tendency to bq more rank or when temperatures are lower than normal. 

Always tost spray to determine if the tobacco is mature enough to respond 

to treatment with PREP1"\( brand Ethaphon. 

Apply ovar-ltle-lOp PREp'Ilol brand 

nozzlos (ono noulo tips over the 

so all leav05 aro coverod 

as a fine mist using threw 

, and on each Side) 

tho i 01 

i. 

o Do not apply PREpni brand Ethophon to immature loavos as this can result in unsatisfactory coloring, woight loss and reduced loal 

quality. 

o 00 not allow the crop to ovar ripen in lho field after using PREpni brand Ethephon. sinco this may cause some reduction in yield and 

quality, 

• Do not treat boloro antlcipaled major storm which could prQvent harvest and rosult in crop loss. 

o Do not apply PAEprw brand Ethaphon if rain is expQCIed within 4 hours. 

APPliCATION TIMING 

SlJC(:OSsfuf results. with PREPni call for treatmonf whon loavos .ora mature, not ovarly rank green when sprayod. To easily detormlno 

tho propor treatmant timing and the numbor of leavas par stalk ready for harvest, tost spray sovaral plants in more than one location in 

oach field and observe the response. Mature leavos will begin to yellow in 24 to 72 hours. Test leaves that fail to yellow in 72 hours are 

not mature and are not r~ady for PREpN brand Efhephon froatmont. Wa~ a lew days to perm~ further natural mafuring, then make 

another tost spray or ~malurity~ check, 

Whon you have confitmod tho numbor 01 leaves par plant that will color, you can determine the numbor of acres 10 treat in order to liU 

the barn. 

Preparo yourtost spray by mixing ono teaspoon of PREPrn in t quart of wator. Spray each test p1ant with about t oz, of this mi){turo, 

coyering allieavos with a fino mist. PREpm brand Ethophon will not color immature sprayed loaves, 

WHEN TO HARVEST 

All mature, sprayod leavQS will bogin to color within 24 to 72 haUlS afler PREpnl brand Ethophon applicslion, Tho yenowlng process is 

weather dopendent; cool weather will delay. while hot, sunny weather can speed up the process. Harvest treated tobacco when loavos 

have roached the desired color Intensity, 

00 not allow tobacro to b&come ovor ripG btlfore sfarling harvost. Leal drop can occur when tobacco is ovor ripe and left on the stalk, 

If a number of the bottom loavl'ls have yQllowod at the time of treatment, thoy should be harvostod prior to spraying with PREpn< brand 

Elhephon. 

With an over.thfi)otop application, harvesting can commenct1 24 hours alter PREptu brand Ethephon applicafion depending on wGalhQr 

conditions or to avoid over ripe tobacco. Tobacco harvested 24 hours after treatment will require more time in tho cpel'ing phase ollhn 

curing proCGS$. : .. :.: •••• 

CURING PREJmI TREATED TOBACCO : .: • 

Curing procedures ant as much an art as a scienco and each cUle must bo judged on tho basis of..~ conOUiP~ V'ItervaJ bOlwoon 

traatmont and harvest. weather and type 01 curing facility bofore proscription temporatUlO sri! V!tntllatibn schedulas can bo 

osiablished. To obtain maximum quality, cartt musl be- taken to observe and controf the curing proces, c!osely",·e:pttciaJIy during Ihe 

late ~colorjng· and early ~dryjng· SlagGS of tho loaf. ..:.. • ••• 

PAEpN bfand Efhephon Iroatod tobacco will have started tho coloring process when harvaSlQd, reQ101&1I9 the time r~uirod in tho 

coloring phase 01 curing. Treated tobacco should bo dried faster. If tobacco loaves are graen or contain some ~a.t1 ~en harvested, 

it may be necassary to color thom for a faw hours. If Iho 103Ve$ a.re completely yellow, tomperature and ventilalioltfltl.fSt be adjustod in 

a mannor to dry tho tobacco as fast as possible without scalding. Onco tho mat Is dried (314 dry), you should foRpw I}Olfnai proceduros 

for curing. Since PREpm brand Ethephon treated i&avos cura fastor, traated and untreated leavos should not bOUlrecttogether in lho 

samabam. 

88 
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LIMITED WARRANTY AND DISCLAIMER 

Tho manufacturor warranls (a) Ihat this prodUCI conforms to tho chomical doscription on tho labol; (b) that this product Is roaoonably I~ 

for tho purposos sat lorth in the directions for use whon it Is used in accordance with such directions; and (e) that Iho directions, 

warning and other slatemen!s on this label ate bMOO upon responsible experts' evaluation 01 reasonable tests 01 effectiveness. 01 

toxicity to laboratory animals and to plants. and of residues on food c:rops and upon roports 01 field oxporioncQ. Tosts haV8 not boon 

made on all varietios or In all statos or under aU conditions. THE MANUFACTURER NEITHER MAKES NOR INTENDS. NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES. EXPRESS OR IMPLIED. AND IT 

EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANTIES OF MERCHANT·ABllITY OR FITNESS FOR A PARTICULAR 

PURPOSE. 

THIS WARRANlY DOES NOT EXTEND TO, AND Tl-IE BUYER SHAlL BE SOLELY RESPONSIBLE FOR. ANY AND ALL LOSS OR 

DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITl-I THE LABEL 

DIRECTIONS. WARNINGS OR CAUTIONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, 

LOSSES. DAMAGES. OR INJURIES RESUL 1100 FROM THE USE OR HANDUNG OF THIS PRODUCT. WHETHER OR NOT BASED IN 

CONTRACT. NEGLIGENCE. STRICT UABILrtY IN TORT OR OTHERWISE SHAlL BE LIMITED. AT THE MANUFACTURER'S OPTION. 

TO REPLACEMENT OF. OR Tl-IE REPAYMENT OF THE PURCHASE PRICE FOR. THE OUANTITY OF PRODUCT WITH RESPECT TO 

WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, INDIRECT OR 

CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDUNG OF THIS PRODUCT. 

NOTICE TO BUVER 

Purchase 01 this product does not conler any rights undor patients govorning this product or the usn thoreot in countries outside 01 the 

United States. 

e lDEF and Guthion are rogisterGd tradommks of Sayer AG. Germany. 

2()ropp is a roglsforod trad~mark of NOR-AM Chemical Company. 

3Harvade is a registered tradomark of Uniroyal Company. 

• 

"Malathion is a trademark of American Cyanamid Company . 

RhOne-PouwtlC Ag Company 

P.O. Box 12014, 2 T.W. Alexandor Drive 

Research Triangle Park. North Carolina 27709 

PREP Is tho trademark of RhOno-Pol.llenc. 

FOlEX is a regislered trademark of Rh6ne-Poukmc . 

PREptw brand Efuephon for Cotton and Tobacco (MASTER) Approved 415193. 

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\ . \- ,~6.J It. i!.~ 

Mr. Warren A. Davis 

Rhone-Poulenc Ag Company 

P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, Me 27709 

Dear Mr. Davis: 

Subject: Revised Tank Mix Directions 

PREP Ethephon Cotton Boll Opener 

EPA Registration No. 264-418 

Your Submission Dated March 9, 1993 

The amendment referred to above, submitted in connection 

registration under the Federal Insecticide, Fungicide 

Rodenticide Act (FIFRA) I as amended is acceptable provided 

you: 

with 

and 

that 

the 

you 

1. Make the labeling changes listed below before you release 

product for shipment bearing the amended labeling: 

The heading "Defoliation and Insecticide Use" implies that 

this product is a defoliant and insecticide. Modify the 

heading so it is clear that this section is for Tank-Mixing 

Prep brand Ethephon with Defoliants and Insecticides . 

2. submit one (1) copy of your final printed labeling before 

release the product for shipment. 

A stamped copy of the labeling is enclosed for your records. 

Sincerely yours, 

Cynthia Giles-Parker 

Product Manger (22) 

Fungicide Herbicide Branch 

Registration Division (H7505C) 

Enclosure 

90 
(;" !JH0!y!=,:POULEIY<;:" , '~~.? -- --

r=r,"' 

I 

AHONE-POULENC AG COMPANY 

ETH 93-UJ 

March 9, 1993 

U, S. Environmentall'rotcclion Agency 

Office of Pesticide Program Document Processing Desk 

Room 266 A, Crystal Mall No.2 

1921 Jefferson Davis Highway 

Arlington, Virginia 22202 

Attention: Cynthia Giles~p(lrker 

Product !I,,1anager (22) 

FUllgicit.'ie l-lerbidd,' I3r,1J1ch 

Registration Division (H750,'}C) 

Dear tv1rs, Pnrker: 

RE: PREP brand Ethl'phull For C\)ttll)( -And Tobacco 

EPA Reg No. 26:1A IS 

This label al1lc:ndment includes;) lIlinor (h,lngc deleting the caption "Compatibility" 

<11td '>llbstitlltillg Ilw hetlding" De[nlianl and Insecticidv LSt'." Linder this section lYC' 

hJ.\,(' added till' statL'I11('llt " FoJ!O\\' ;dl applicable prCc,Hltit)JlS dnd T,ltes pCI' acri..~ 

n.->commenddtions (In tlw producb ,lpplied ill sequence or tank-mixed \\'ith Prep 

brand Ethephon For Colton and Tnb,lC(U Llble. 

To complete our 5ubmi5:;inll \Vi..' h.lve enclosed an application for ilmended • 

registration and 51,lbcl$. l\Jo offers t(l pny 'Wl~re filed to support this request a~n· 

Rhol1c-Poult','nc is till' only registrant listed in the EP;\ index of data submill<;l'S Jh:It 

has clunJh,~n:'<1ble d<ltd on file 1.'.'itl1 tlll? Agency. In ,H,.idition tht! l1<1t\lre of the ••••• 

prnpos(:d changes Lin",s nut n:''J\llI'e additional supporting d,ll,l SUblllission... • 

• • • · .. We desire to print Ill'\\.' pmdlli.'1 labels wi thin 60 d'l)'S ,U1d would appn:..-iate i.r·tll~ 

minor ch,mge could be rC'l'!el\'l'd promptly. It YOll ha ve an)' q\l«stions plcast: ·cqnb(t 

me prl)lnptly. \Vl' appn!(:izltt' )'t.!llr <1~Sbt,1l1LC. • •• 

•• • •••• 

VVJrren i\. Odvis 

Senior i{!!gistl\lliun \1<1lug~:r 

• • • •• •• •• 

"'0 [fOX IlC\~ :,,',', ;,' ~rA';C{'1 ~';',:':L 

HfS\:JJlC';'W:PlU.FN'd< 'Ii.. . 

('lUi ~,~j ,(<-Xi 

,i'lTU1'j,\'LCI.J.1 ,FtU [.UiiE>' {"'c"'" 'I' ."r':'\"~,,uU_}.:-f '_' ,I" _"'U;NX'O~'Ai. f)'~.T ,rB;J1 ,,~,: < ,,1-1-: (I' ~ ,~, , 'l.e,I.'[,I. '( ~c,._,·.j < ."« '~~'h;';IV·', ,_ p. ,-':. 

91 

•••••• 

• •• • • . ..... 

• • .. • •••• 

• • • •••• 

• 

•••••• 

• .. • 

• ••••• • • • ••• 
---._--- --~~ .... ~.-

PifNJ!HI NNld hVmvcthmil (til f'tJVW'$f1 b#0Nt ,'.,om" """ 

(Al&EPA 

, Registration 10pP 'oo""w ""mba 

0000 W .. "'",,,,,,. DC 20400 

~ Amendment 

Application for Pesticide: other 156511 

11_ CompanyiProduct Numoor I<~~f 1

3 , 264-418 " 

,..t Ccmp.tt/'\~t{Nam6') IpM' ,,~--

DNolU) D fWSlIit:cd 

PRE . rand Ethephon Cotton Boll Opener # 22 

15. Namo and Addrof.$ 01 Applicant CcOO} 

Rhone-Pou 1 ene Ag Company I ~b)(i), my product i! 51~i:~r or idontica~ i~~~mpoSition and labeling 

2 T. W. Alexander Drive to: 

Research Triangle Park, He 27709 I EPA Reg. No. .--. 

o Check if fhis is a now address 

t II 

Explain below Rnal printed 11\0015 in response to 

Agency latlof cial!)d 

f- .. --~------

in fIl's.ponw to AgooC)' Iouar datnd . "Me Too' Application. l- fINotilicalion - Explain below. 

Otlwlt - explain below. 

pagel!»~ if nllQla:sary. lFor suction! and Section 11,) 

1) Added precautionary wording 

2) Range of notes for cotton in Southwest 

(see cover letter) 

Section III 

I ... din, 

I

U

'" 

r- Yes 

I"~ . ByO" I E Yo. f-j;'! 

No No 1-1 No 

. No, pet 

pa:::~w~t. No"" t= , • CertilicBtlon must be waf contalner 

, '" , ••••• 

1'- I' S"o(') of ,,",,' _ ~ ~"'" i ".: ; 

o La".. ,..., B ~ t;;;;;;~M ~"""~' .':" 16 Ma"",', ITo Pro,,"d 

1= DOmffl •• 1 ••••• 

• ••••• 

'.. : 

11 wCO" -; 

IN'~ P"'" NO: j 

Warren A. Dav; .:: .. s ISenior Registration Managet ~;,.~. 

, '.": 

j6 . I CC:rtify that the S!Alaments I haw made on Ihlslorm and all nttadwnonts Iheroto MO lItle. IlCCUfalc and compl&1Q, 

I admowfedgo fhat any knowingly 1111£0 orml$loadtng $UtlCmont may be punishable by line or ImpritOtlmf)fll Of (StampG'd) 

both uodnr app6cable law. 

I' 

ttI~-I/6.. ,.-- 1'_ T". ....., i Senior Hnn 

,'- ,S. Om, 

War)~en A. Dav; 5 !March 9, 1993 

~? 

e • ., WhiOo - EPA F .. Copy ,,«ow 
----~.-- .•... --.•.. ~----... -.--

PAPERWORK REOOCTION ACT NOTiCE and INSTRUCTIONS 

PAPERWDRK REDUCTION AC1' N'O'rn;Er MUc tl'lp&rtiflg oor<kn feif' tlliz wl!nctltm \i1 '{flfqrtm{1,,;n i~ 

clltimoted to ~v~r*g& v.as howl" per (W0ponte, i~lvd!~ tlF¢ for reviewing losrructlb0D, tenrchlng existing ~t8 tCVfc§~, 

g0tMriitg .nnd mh\r;t1>lnifl» the data r~, NY:! c0«plll'tim arKi tW-1lwl.ng the cCl!w:-tiWl \Ii ihfcrmatioo. Stmd C~a 

r"SI!rdir~ tnll' btlrwn Ntlmlltfr -Of ooy dttmr i1i:Jpcct of rhh ({)!iut\tm of IntefMt1c>o, indudif',g SUl?J1Mtiooa for reci<Kino this 

b'Jftitn, to Chief, IhfcfllUtlm Polley Bmrw:tr, PM<023, U.S. £lWir~a[ I'NtKt!OO Mtr:.cy, 401 M :>ttfMt, $U, v0shlrlgtG-{1, Dt 

ZIYo{;G; end to the Ofiic0 of lflfofw.s'ncn and H&gDlatcfy Affairs, DHlcce i)f MM8qJNf4flt i'.U¥1 Boo;Nt, lJalll:!;0gtcn, DC 20503. 

INSTRUCTIQN§j: rllIt ferm it to Ix: tiiLd for nil apptlcutk{'$ for f1!.W resi5tr;;,!8'l, we WlU rH'!9;,nrathm, w;%r=nt, 

rc;~Lt~dcn, to llW!i~()t;C.-'% for Mtif;cQ,ii;)fW, hrui print!!d !awtin(;l, reregistration, etc. In arOOt to prCC411S lYl 

application f{!r <I fWW registration fiUmltttid «l. tht£ form, till'! foU$ling IMterj",\ ant uc~ the >1!ppl!enti«l.l 

1. CertlfieatilU'> j,ilth t/otp«:t to CIt:nl«l. of V!lta (EPA t(lM!\ ts70-Z9). (If oot ewmptoo by 40 Cfrt 152.31 (0) (1.)1; 

2. COI'Ifid%ntin\ Statemmt of formula (ePA f!i'rm 115-7(4); 

3. fotbUlntcr's exemption Stat~t tEPA fbrm 3570-27); 

,(,. five ccpiu of draft llltx;Una; 

5. Three «;pies of any <fuu sl.lb'!littedi 

6. Authorizllt!M letter where I1ppllcfiole; 

7. Hatrfcet where appticable. 

Sul::i\I\sslon of l&belir11j - labeli1\9 should flr!;t be slbtltted in the fom of draft blbets with ett application:> ft;r nw 

registratfco. such draft: tbbels may be in the form of tYPed labet tt-xt co 3.5 x 11 inch pap«r or Q moelicp of the: proposed 

label. If prepared ae a PrJCKUP, it should be constructed in such g way ~~ to facflit4te storage ln on 8.5 x 11 inch file. 

Mockup labels $isnifieantty 1maller thM! 8.5 x 11 ir.chvs shoutd be arnmtoo on 3.5 x 1\ ir.ch p6per for- Uubmi$SIOi1. 

SIbIIIin100 of Data ~ Oata st.bnitted In support of this application rnst 00 M ..fuittoo fN accor~c, \lith PR !lotk;} 86-5, 

determine 

SPECIFIC 

the t'fJ" 

INSTRUCTIONS: 

of regl;:traticn action, 

Pte:me 

listed 

read th 

in 

... 

Block 

lMtn.ICtiOi",s 

A, for l<hich 

tlllt«l 

'fOIl 

bftlClJ 

!IIrc 

before 

su!::mittirt@ 

e~tf;!tir1S 

this nppticatiOf'1o 

thf$ IIpplklitleo. 

for 

First I 

IIppticatlorui sobmittl!d Iii ~OlIDe¢thm with NIW Regh:trlldoo actions, $¢<;tirum I, ltI, and IV i'Alst 00 cO!fiJllltoo by the 

applicant. for applicatiQO$ submitted in c~tion with ~ regfstr-atlon actions, re&ubrnis51on#, notlflcati0n3. 

rereglstrlltiens, etc., Sectiorw I, fl, tmel l'llWSt be cOlVf)teted 171 the Itf'Plicant. 

aleck A ~ Check the 3pprcpriate action for- whlch you ure $ubmittirt@ this form. 

SECTION I ~ This sectiru"lll'lJ$t be cOII'plllted, as applic3ble( for at[ rogfstratl!m actions. 

1. ~/t'rodJet: ftu:lber ~ InU!rt Yo(lr ~ Nlo!tix!r, if one has been anignOO by EPA. Thit ~r !My !lave been au!gned 

to YOO fiG a bUle rQiiiarrmt, Ii dlstriwtor, ¢r as an f1Hoollsl'm¢nt. If Yt4Jr prOOJct It r~!$ter-~. int~rt the Product 

Nwbor. 

2. EPA Pr-lXb!t Kll!wger ~ If kl1OWfl, fill in the 1'1_ nl'!d PM I'lU'Iber of the EPA Pr«toct ~g('r. 

3. Prqxmed CIM-5fficntll.lO ~ Specify the prcpo1loo e\v$siflcatioo of thiS /UQOOet:. 

4. Pn:O.JCt ~ ~ Enter the coo:pletc prlXkJct rw..''')lH)f this poHtlcide till it wtt! apptNlr on the hbet. The n/!IWI: must be 

speclfic to this product ooly. Duplic!ltlon of tIfIItoC$ [$ not permitted ~ products ¢f the !i:1ll\!Ie company. vo Mt inelude 

any brand name or c~ny line Ocsignations. , ' 

5. H_ and Addf'esa 6f AfptiCMt ~ The It1lt<Ie of thff tim or perllQl"l and &OWe$§ sh!l\R'j II'1)'Wr awl ieation is th4- person or firm 

to offiQrn the fcgls.tratloo wilt ba issued. If ycu are m:tiJ'!!l in bcilalt of another pt'lrty. you lW$t !'iubm\t amwrfzlitlon frW! 

that party to act for thern In registration rMtters. An applicant not residing 11'1 tho:! Urdted States Jl'Ll$t: hove an I 

authorized &gent residing ;1'1 the United States to net tor them in att registratloo !Mtters. The n&14 and complete ®ai!i 

addreilS of weh an agent !llJ$t iKC~ this IippUcaticn. 

6. Expedited Rev;mt - fffAA sactioo::; (c) 3 (5) provlde$ fer qXpl!dited r1T.jiew of apptieaticm for regl$tratioo, or ~t 

to «)(1$t1ng Ie-ghtratioos, that arc llimilar or Id«!tieal' to- ether pesticide prcWcu that lire currently regi&tllred with 

the EPA • .... rdctr fOr your application to- be ellglblo for {,'xpt!dlted review, you l!W;t provide us With tho EPA Registrnticn 

•• oHi.$(w and PI-<Xb::t r;MlC of the product you b©licve Is ",{",Hill' to (lr 'fklnthnt to your fWo:.:lw;L Th>: p.rn4lct lIMIt, be 

: -Siml lar u: ipcl\'1,feal if> b¢th forwulat Ion t>rd lebeted wee\! • 

•• •• •••••• 

~ION I·I - Thh s(!ctlan !amt be crwopletoo fQr- att apptiCtltioos s!..b1litted to woffid fill! reOl$tratien enly of 11 

~wsty rl!jihtpf! proriuct (Alnu'd1.cnt), for a restb\1iniw in resp¢I'I£c to an Agency lettltr, fCI1" ootlf/cntiens to the 

~ir::Y~ for tt.at s*,s!idoo of fin()l printed labet/ng, for rercghtr!ltioo ru;d for nny other- actioo that p$rtalns te a noo;if!c 

~:rHI!itltrn~. This .section is!!2! in £! USul tor II 1l'¢0l applfc.:ltH)(,I f",r rtrghtratlen. 

1. $Wjllet oJ- ~h:SiM • Check the aWl leable blod; nod provide: tho Aget)(y letter dt.te if ~cpriatc. Provide a brief 

:··Wl1Nltioo,pf the p!Jrpose(s) fqr the '~i&'J;ioo, such a<l ~thtl: addition of a sitJ:, pest 0; crop (specify)"; "amend the 

"ConHdooti8~ StatOOlOOt of fornut:a by ... ~; "rer~h:tratioo S>.blll1lSioo"; llUlerat label rwisllXl of Ul~e dtrectiCM." Attach 

•••• ~rat.t·paQl;!:if OOditlonnl space Is need«}. •• •••• •• •• 

SECTION: Jilt. (Packaging and container Information) ~ This Section f1mt ~ c-wplo:!too f{)r all 

eppUcati«MtlutL'tted in cOI'lrfecticn with MOl rttglstrbtion or apptlc.nble ~u. 

1. Type'of PM:btuins ~ Check the appropriate b[rn.:k If your product wilt be packaged in the indicMoo pac)({I[Jir,g types. 

lndicate the $i10 of th!;! individual packets and ~r p¢r retait container. 

2. Type of Retail Container ~ Indicate type of c'Mtalner in whjch prOO;ct vII! be l!'oIIrket<td. 

3:. location o-f Met tcntMt#- ~ Specify the net contents of ... tl retail c.:;ntainers for your prodoct_ 

4. Si~e(s) of Retail Container ~ Sp<lcify the ml; Contffit;; of alt retAil coota;/Wrs for yovr product. 

5. l~tioo of Uue tlireetlorn; ~ Indicate the l.x;atloo of the ooe dlrect;;:,r,tl for yt'iUI" pro4.lct. , 

6. KwTIer in lAtich labei 1$ -affiltoo to pn:dtct ~ tndicate the IMthoo prod<J<;t label IS !ltt;M;heQ'~t.f) retail cOOttliMr", ~ ",~,%,,"""< "" '-,," ",,;;,;;;, 

SECTIQH IV (Contact Point) - lhlt slktico m.Jtt be coq:.tet«1 for all applications for RlI9istratloo ect!cm, 

i .t., new products regllltrJ:ltion, 

l-5. Self~t.)(pl/101ltory. 

6. EPA Use Oniy. 

rl:!;;t.bnissioo, "me-tlXi," reregistration, etc. 

93 
, IA)'&EPA " oC 20460 

o our Pesticide: 

n I 

Registration 

Amendment 

other 156511 

r lr 

~~ ______ ~ __ ~2~6{~f.~4~18~ ________ -4:,:'C"":.:P~~~:: ~ 

1,1. co;~~~~:~am;~hePh0n CottO!} I" . .,~ o NOM 

no j 1 Op£mer if 22 

(fncJudo ZIP Code) 6. Expedlted.in accordance with . 3(c)(3) 

(b)(i), my product is similar or idenlical in composllion and labeling 

10: oy 

DriVe 

EPAAeg, No"" ______________ _ 

o Chodt; if /his is IJ new addrru:s ProQue! Noma 

Final prinWd 1n00t$; in rosponso w • Amcr.dmcnlo Explain botow 

~ R&submissioo In response 10 Agency Ic!tcrdalad' ____ _ IAgency Iottllrda1Od", ____________ _ 

I-- Nolilicalioo + Explain below_ 

I--

Explanation: Usa addillonaJ P.(s) if nocessary. (For sectioo I and 

"Me Too' App!lcalloo. 

l-I Ot!wr - \)Xplaln lxllow 

fI' II .. 

IUnn 

OIn' ~----------------~ 

,8 Yes~ ,: r YOIl I-I YOS 

No' Nn No 

• Certlflctdlonmustbe Ii hf;~~~~:_-N~.~,~~~_t~";~~M~,~.~~-_:No~,~~P.:1 wgt conlainM PackageWgl container 

I .' : : 

••••• Or 

15, .,t."", 

I El~;>;;;~, ". P,."",, rID om«L----_____ r~·~·iL·) ••••• .. .. 

IN.~ '. 

Warren 

I (';(Mlily math statements I have made on mis form and aIIunachmenlll thereto are !rue, aocorato and compklta, 

! acknowlodg& thai any knowingly Ialro or misleading stalemool may be ponfWabkt by line or impri&Ol1mOOI or 

both under appUcabio law, 

f3 TnIo 

I"" iOY' i'vihlY0! i(v, ,. 

Whil« - EPA 

(SllImpcd) 
PAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS 

PAPERWORK REDUCTIQN ACT NOTICE: Public reportins burden for this collectioo of informatitm is 

estirMted to avenge 0.8S hour per r«lpoml;}, iocluding time for revIewing il'l4tructiO/l$, ~ellrchll'l!1 exiMfOQ data s<wrces, 

gat~rinv and maintaining the dahl ~, lind cCi\?letir.g .md reviewing the- collection of fnfc.rmation. StlmI cocrnents 

regllrding the burden estimate ttl' any other flSpect of thi$. collection of irtformti"". including SUijscstiOfW; fer reducing this 

burdett, to Chief, Information Ptlti~ llrOOGh, rth!'Z3, u.s. EfWlronnental Protection Ageney, 401 K Street, S~, WlIshinatcn. DC 

20460; and to the Office of Inform:ltlon and Regulatory Affairs, Office of MaM'ilement lind eudgot, IJllshington, OC 2050:5. 

INSTRUCTIONS: 1his f6Nn is to M U5ed fer all applicatiOM for new regIstration, end use rereaistratioo, llIOO~t, 

rllSf.blIission, to appllcatioru for tlOtificatims, final printed labeling, reregistration, etc. 1n order to process at'; 

application fi)l' \'I IW# registratiOl'l st..b11lttoo on this iorm, the followIng !llaterial nmt accoorpany the appticatlon: 

1. Cf!rtlficntion with RHfXX:t to Citation of Data (EPA form S$70-29). Of Mt f!xOO()ted by 40 erR 152.81 (fl.) (4)1; 

2~ ConfidentIal Statement of formula (EPA Fona 8570·4>; 

3. formulator's fxlI'!!'pUon StIlItcmmt IEPA fom S570-27); 

,. five copies of df"ilft label ing; 

5. Three copi" of lilly data sublilttcd; 

6. AuthoriZation letter where applicllble; 

7. Matrices wheri!' awtfc>1Ibte. 

SUballuion of labeling - l~tlng should flrst I» slJbnittod In the fom of draft labels ~ith all a;:plicatfOlW for new 

registration. Such draft labels Ny be In the form of typed labltl tWlt on 8.5 x 11 inch paper or a mock.up of the prOJXlS«.l 

!3bel. 1f prepared as 0 mockup, it llhe<.!ld be cctl$tructed in su.:;h a vlIY liS to hcil itllte storlllO'l' in l1l'i 8.5 x 11 inch filf!. 

MoefWp labels aillfliflcantly smallor thm 8.5 x 11 irn::hell' should be! mounted on 8.5 x 11 loch paper fot' subnfs!:lOl'l, 

SUaihion of n.ta ~ Oua sutmlttod in Sl.fPOrt tti this IIWlicatlon litiS! be subnltted in accordance wIth pft lIotiee 86·5, 

SPECIFIC INSTRUCTIONS: PlellSe reOO the lru:tructlom listod txllow before completing thIs applicatIon. First 

~termine the type of registration action, listed in Block A, for whlch you are submItting this awUcatloo. for 

applications sub'aittod in c6n!'le(;tioo vith 11M! Registration actioru, s(U;tions I, Ill, and 1V Il'Uiit be e~letod by the 

uppticant. For awlieatiOl\\l ,\bI!itted in cOl'll'\(tCtion with ~ registrtltlon actions, rfl'SUbllluions, notifieations, 

reregistrations, etc., SectiON: I, II, Md IV trtnt be coupleted by the 8pf)ticant. 

8locl:: A - Check the appropritlte action for which you aro stbllittins this form. 

SEC'rIOlf I - ThIs section !l'mt be cwplettd. as OWl icabl~, for al t registration actions. 

I 

1. CaIpIny/procb;t: MlIIbcr - Insert yow- COIIlpcny MUJt,er, if one has btwro u,igMd by EPA. This ~r Ny have boon auigned 

_ 

to you IS It basIc r%!lstrent. a distributor, or a;s an estnhffthment. tf Y«Ir product is r~i$tltred, insert the Prtli:b:t .. 2. EPA Prcxb::t Konoger - I f known, fl II in tilt> NIIlII and PM rtI.l'I'b<Ir of the EPA Product Kmager. 

3. Proposed Clas.sification - Spedfy the prOPOIlOO classiticatlon of this product. 

1,. PI"tlICb:t II-.: - Enter tha couplete product name of this pesticide- 48 it witl eppoar on the label. The rnIfi'Ieo must be 

spoeffic to this product only. Ouplicatlon of f\aIIlH is not perl'llittoo 1Ii!IIOO9 products of the s_ cwpany. 00 not include 

any brand IlaIIIe or c~ I iM designations. 

5. M_ QfltfJd.tres,s of Applfc&nt - lhe I'Wf4 of the ffl1!l or par$¢t13l\d a6Jrcss slwwn in your application is the pl:!rsQO or firm 

to WlOIII the registration wItt be issued. If you are acting In behalf of another party, yo\IlWst submit authOrization frOQ 

that party to &et for them in registration JIIIItters. An app1 icant not rlf$iding in the United States IiUSt have on::& 

6Uthorized agent rolding in the unIted States to act for them in aU re;istration lI'.atters. lhe NiII\(t end cooplete _ltl 

addrKS of SlJCh en ageot !lUSt aecOll1)6ny this appl jc&tlon. ' 

6. Expedited Revill!fll - FllRA Sl](;tion 3 (c) 3 (It) providee for ellP¢ditod r~few rn appticatiOl'lS for rogistration, or 

to existing registrtltions, that are eltllllllr or identical ttl other pesticide products thtlt are currClltly registered With 

the EPA •• tn.order for your application to 00 eligible for expedIted review, you ffiU$t provld€: 1)$ With the EPA Registration 

•••• ~r ar,q"produc:t I'IiIII\a of the product you bellieVl! Is similar to or i&.nticlill to}'<>Ur product. The product m.Bt be 

•

•• s;"'flllr.,r Idfmtical in both forNlatien lind lebeled Wies. ... ... 

•••• :)itt:rXON ,I - lhis uctiOl'lllLl$t be c~lnte<:l for aU applicatIons sul:l!littod to GIMf'Id the registration only oi a 

currently ret,istc.red prodJet (~t), for a rc§!.Jl:Eiis5ion in response to an Agency li'!tti'!r, for notHiclJtlons to the 

• ~9IMvk for'iel stbmission of firml printed lobetlng. for rer~j$trlltion .nd for any other action thiilt p!!"rtains to I) ~pru;.;:fi5 

m'ftgiltoccd Woduct. This Gection is D21!9.12i used for a oow application for regi;tration. 

~ fkbject pf·9Priasion - Cheek the npplicablo block MId provide the Agency letter date if appropriate. Provide- a brief 

:.·.tlltplana:tion of the pal"pOse(s) for the submIssion, such as "the,ao:kUtion lit a lite, pest or crop {specify)"; "M1Crd the 

•• ·conffdmti~l Sttltlll!!reflt of forll'JJla by ••• "; "reregistration WbIIlssfon": g_ral label revis;ion of use diractioru;," A'ttllch 

••••• .separl}t\·H if &dditlonal space is~. 

•• •••• 

•• •• SBCTIOI ,,!IJ: (Packaging and COntainer Information) - This Section must be cooplet«l for all 

appt!clJtiotV .. itted in conneetion wIth nIW tegistratiom or 8pf)ticabte ~ts. 

1. Type: of Packagi~ - Check the tlppropriate block. if your product will be pad:allccl in the irdicatro packagIng tytWli. 

Indicate the sit. of the fl)jiv!dual packets and I'i\.6b(!r per ratail C«Iuioer. 

2. Type of Retail container - Indicate typt! of conulner in whIch product wfl 1 be IUrketed. 

3. Loeetion flf lIet contents - Specify the net contonts of all retail eootalners for your product. 

,. Sines) of Retail Container - specHy thlt net contents of all retail contaioors for your produet. 

5. Location of Use Diroctiom: - Indicate the location of the USIt dir«:ttons for your product. 

6 ....... 1' in ...ttich label,. afffxed to procb:t - 1ndiente the I!lethod product l$bel is attached to retail contairwr. 

SECTION IV (Contact point) - Thlli Section ffJJst be ctq)lltted for fill appliCiltiom for Regbtratlon actionli, 

i.It., ~ products registration, rosubnission, "me·too." reregistration, etc. 

1-5. sel f-olq)lanatory. 

6. EPA u.. Only. 95 
IQ: PILli ROOl( _________________ _ 

lXlCUKElIT C!IITZII ______________ _ 

PROOQCT MANAaElI. ---_~ ____ ~~?6~~~ ____ __ 

PAll (ROOM 263) 

TYPE Of REqrSI?JJ:9N 

PAST - TRACE ACTION (with ~thout da~ This action has b •• n determined to b. a tast-trac:k IC'eion 

by FEPS and ~ ba antared in the PRATS uI1nq on. of the 

follow·inq cOdes: 

160 - Application for "me-eo" reqistration 

l70 - Application for reqi.tration - old chemical - "Matool' with additional u. ••• 

300 - Amendment - laQal revision - administrative (no d:at~ t'equired). 

305 - Amendment - label revision - data required dee. nQt 

ne.d HED/ErED review. 

310 - AlI1end.ment - added "me-too" Use - no HED/EfED revie..., 

n •• ded. 

345 - Formula chanq. - no HED/EFED review required. 

REGOtAll REGISTRATION (with data/without data) 

24e II7llf 

He ~lI%lI'1' 

RE8UDXI.IION ( ••• poa •• tQ AQ8DCY lt~) 

rI~·PaIlITBO LABILa 

QTIlIa 

1I%881\GI' ______________________ _ 

96 
97 
a 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

MARGARET CHERNY 

RHONE-POULENC AG COMPANY 

P.O. BOX 12014 

03/26/93 

RESEARCH TRIANGLE PARK NC 27709 

OHiC£OF 

PREVENTION. PEStICIDES 

AND TOXIC suaSTAtiCES 

Product Name: PREP BRAND ETHEPHON COTTON BOLL OPENER 

Company Name, RHONE-POULENC AG COMPANY 

Application No.: 156511 

EPA Reg. No.: 264-418 

EPA Receipt Date, 03/25/93 

Subject: Front End Screen for an Amendment 

Dear Sir or Madam: 

Your application for registration has been received by the 

Office of Pesticide Programs and has passed a preliminary screen 

for completeness. It will be placed in line for review to 

determine its acceptability. The application will be processed 

in chronological order of receipt. 

Although the 1988 FIFRA amendments mandate EPA to review 

applications for expedited registration or amendments within 90 

days, this turnaround time will not be met immediately due to the 

backlog of applications received before December 24, 1988. 

However, EPA is increasing human and automated resources and 

making necessary procedural changes in order to eliminate the 

backlog and to meet the 90*day response time as soon as possible. 

If you have any questions, you may contact C. Giles-Parker, 

Product Manager 22, at (703)*305*5540. 

Sincerely, 

cd.Af)JJ...~ 

Team Leader 

Front End Processing Staff 

Registration Support Branch 

Registration Division (H7504C) 

98 
• 

• 

• 

• 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON. D.C. 20460 

APR 5 1993 OF~aQF 

P~""'EN1\ON. "ESTlClOU 

MlO rox'c SUBSl"t.cCS 

I, cynthia L. Giles~Parker, Product Manager, Fungicide-Herbicide 

Branch, Registration Division, Office of Pesticide Programs, Office 

of Pesticides and Toxic Substances, u.s. Environmental Protection 

Agency, do hereby certify that the pesticide product listed below 

is currently registered with this Agency under the Federal 

Insecticide, Fungicide, and Rodenticide Act, as amended, that the 

label attached is a true, correct, and compared copy of the 

correspondence of record, and that the product may be sold and 

marketed in the united States of America for the uses indicated on 

the label. 

The product registration listed below has been issued to: 

RHONE-POULENC AG COMPANY P~O. Box 12014, '2 T.W. Alexander ~Drive 

Research Triangle Park, North Carolina 27709 

EPA RegistratiQD Name Qf Product 

264-418 

I 

... 

" 

, 

, 

\ 

\ 

PREpN brand Ethephon for 

cotton and Tobacco 

IN WITNESS WHEREOF I have hereunto 

set my hand and affixed the seal of 

the U.S~ ENVIRONME~tPROTECTION AGENCY 

this ~ day of II..J A~ D. 1993 

···~.d-7~· , 

cynthia L. Giles-Parker 

Product Manager #22 

Fungicide-Herbicide Branch 

Registration Division (H7505C) 

,,"":'a 

~-­ _ .. _-- __ 

99 
- - - -- --- - - . -~-------

r-- (.- - i '1I~ RHOfIJE-POULEflJC 

• "---.J 

• 

• 

• 

• 

RH6NE-POULENC AG COMPANY 

February 19, 1993 

Mr. Robert Taylor 

Office 01 Pesticide Programs (H7505C) 

Document Processing Desk (CERl) 

U.S. Environmental Protection Agency 

Room 266A, Crystal Mall 2 

1921 Jefferson DavIs Highway 

ArlIngton, Virginia 22202 

Dear Mr. Taylor: 

Re: PREpTM brand Elhephon for Cotton and Tobacco, EPA Reg. No.: 264~418 

Please provide us with five (5) certificates of reg/slr,alion for the product referenced above. Please 

Include the following Information on each certificate: 

(1) Registrant: Rhone·Poulenc Ag Company 

P.O. Box 12014,2 T. W. Alexander Drive 

Research Triangle Park. North Carolina 2n09 

(2) Name of the Product: PREpTM brand Ethephon for Cotton and Tobacco, EPA Reg. No.: 264-418 

(3) The phrase wilhln the body of lhe paragraph: " ... that the product may be sold aod marketed in the 

United Slales of America for the uses indicated on the label." 

Since one of these certilicates will be needed in the country of request In 30 days, / would appreciate 

your ass/stance in expediting my request. Please contact me at (919) 549-2112 should you have any 

questions. 

Sincerely, 

Judnh L. Moore 

Administrative Specialist 

• ••• • 

•• • 

•• • • • 

• 

•• • • 

• •• 

•• • • • • 

.. 

• •• . ••• 

• • • •• •• 

•••••• · -. • 

. ..... 

• • 

.. • ••• 

• 

• 

• ••••• • 

••••• 

· .. 

~~vl~' ['~ .~.~' :V~:~N'.~.f.~"~'!. '~Lf;~A;~;:'~'''~'',:~,: ' " ',c ~-';,"j 

,\I<;",'.!)<,V<hM\: c:'P 

_I. • I; f)!i -,- ,tt i.-X"" '),'[;1.(1 k}<?;,," i·,",\\\,C",'»:-" N",- ';_:'. 

100 
PREP TM BRAND ETHEPHON FOR COTTON AND TOBACCO 

For Commercial Use Or Agricultural Use Only. Not For Residential Use 

ACTIVE INGREDIENT: Ethephon (2-Chloroelhyl) phosphonic acid' " .................... , ..................... " .......... 55.4% 

........................................................................................... 44.6% 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

PRECAUCiON AL USUARIO: Sf usted no 100 ingles.. no usa 9ste producto hasta quo la informacion on la oliquela Ie hays side O)(Plicado 

H 

j ~~u~,~.~~~~~~~~~f,t~~~~~~~~~~u~,~.~.~~~~~~~~ . Patents 38, ,188 and ',:,;,,0:8,9:, granted to use this product other than the or iii for any 

nol contemplated by this Uability for patent infringemont may result from use or sale 01 this product outside the United 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EYES: Hold eyelids open and Hush wilh a gonllo slrllam 01 waler for al leasl 15 minutes. Gol medical anon lion, preferably an 

ophthalmologist 

tF ON SKfN; Immediately wash skin wllh plenty 01 soap and water. Remove contaminaled clothing and shoos. Wash clothing 

separately boforo reuse. 

fF SWALLOWED: Do not induce vomiiing. Promptly drink a large quantity 01 milk, egg whiles, gelatin solution or if lhose are not 

avallable, drink large quanHlies of wator. Avoid alcohol. Cal! a physician immedialely. 

IF INHALED: Remove victim to frash air. II not breathing, give artificial respiralion. Administer oxygen it necossary, Got medical 

altention. 

PRECAUTIONARY STATEMENTS 

AZARDS TO HUMANS AND DOMESTIC ANIMALS 

/ 

I • ANGER 

,00ROSfVE. Causes eye and sk"ln damago. May be latal if absorboclthrough skiii Harmful 11 swallowed or inhaled, Avoid breathing 

sPlay mist. Do not get In eyes, on skln or on clothing. Wonr fullleOQlh trousers, long sloeved shirt, protoctivG gloves, and 9099\05 or 

face shiold when handling. Change 10 clean work dothes daily. Wash thoroughly with soap and water after handling ~4d. bGfOfe eating, 

or smoking. Removo and wash contaminaled clothing before rouse. Keep away from domestic animals. • •••••• 

NOTE TO PHYSfCfAN ••• : :.: 

Thore is no spacific anlidolo. Alltreatmont should be based on observad signs and symptoms 01 distress in tho pat:ent·bvere~ttt 

10 materials other than this product may have occurred. • •• 

Victims of severe overexposure, by inhalation, should bo kept undQr medical observation for up to 72 hours for delOYctq.gl\set ot· .: ••• 

pulmonary edema, In a victim of over-exposure by ingestion, caretul gastric lavage is required due to the possibility.of 11q.mach bt ••• 

esophageal perloration_ This material is an acid, but use of alkaline substances to neutraliZe It is contraindicatoo.. ••• : • 

• ENVIRONMENTAL HAZARDS • •• 

Do not apply directly to water, to areas whore surlace water is present or to intertidal areas below Ihe moan high wa~tJwA. 

contaminate waler when disposing of oquipment wllshwaters. • • 

• •• Do not contaminate water used for irrigation or domestic purPOSl1s. • ••• 

USE PRECAUTIONS 

Do not apply PREprn brand Ethephon through any type 01 irrigalion syslem. 

• ••••• • ., • 

Avoid spray drift to noarby crops as this prnduct will cause modifications in plant groW1h< Plant infury or reduced yields will resull. 

Do not plant another crop within 30 days after troalmenL 

Mix only the amounl 01 spray you expect to usc each day. Do nOl allow mixed solution to sland overnight 

101 
DIRECTIONS FOR USE 

It Is a vIolation 01 Fodorat Law to UlH thIs product In a manner InconsIstent with rl8 labetlng. 

Read enllre labol bolor. using thIs product. 

REENTRY STATEMENT 

Mixers, loaders and applicators must wear a tull /aCit shield, long trousers, long skJ,ovoo shirt, gloves and boots to avoid as much skin 

and eye contact as pouible. 

Do not onlor treated liolds within 24 hours after application unless protective clothing is worn, 

nO! contaminato water, lood. or 1000 by slorago or disposal. 

I" ''','''Iain.,'. broken or contents have spined, lolrow an precautions indicated above and clean up immodralely. Belore deaning up, 

po< on,"" length trousers, long sleovGd shirt, prolOClivo gloves. and goggles or lace shIeld. Soak up spill with absorbont modia such 

sand, earth or other suitable material and dispose ot wnslo at an approved wasle disposal lacWty. 

DiSPOSAL 

l~,,,,ticid •• 'as'''.are acutely hazardous. Improper disposal of oxcess pesticido, spray mixture, or rinsato is a violation of Federal law. 

wastes cannot be disposnd 01 by Use aCQ;)rding to label instructions, contact your Stato Pesticide or Environmental Conlrol 

or the Hazardous Waste roprosontativG at the nearest EPA Regional OWCG lor guidance. 

1?~l'AINIER r 

GENERAL INFORMATION 

COTTON 

Ii aod d.,>o~."I.i: a sanitary 

A fo~ar spray 01 PREP1~ brand Ethephon will accelerate opening 01 malur& unopened oollon bons and enhanco dglonatlon which can 

result in earlier harvest with an increasod recoverabl(!l yield. PREPi>:' brand Ethephon treatment on cotlon allows incroased ofiiciency 

lrom a once-over harvest. 

TOBACCO (FLUE-CURED): A to liar spray 01 PREPJ~ brand Ethephon promoles early. uniform "yellowing" 01 mature tobacco. 

PREp1Id reduces curing timo, allowing more efficient use 01 curing barn !!ipace, and inctoas&d control over harvest schedules. 

SPRAY PREPARATION 

Add 112 to 3/4 01 Ihe required amount 01 water to the spray lank Start agita!ion. Add the roquired amount 01 PREpn.o brand Ethephon, 

and tho rgmaining amount of water. Prepare only as much spray solution as can be used on the day 01 mixing. Do no! allow spray 

solution to stand overnight. Do no! spill tho coocentratod prOOuc! on $pray equipment, or any airplano par1s, 

I y SPItlS SHOULD BE RINSED IMMEDIATELY WITH PlENlY OF WATER 

$001 a nurso lank is highly recommended . . possiblo spins 01 concentrated formulation on spray equipmont or any airplane 

arts. 

Good agitation in tho spray lank is ossontial and 11 tank mixtufl) should not be .allowed to stand without agitation 

minutes. Read and observe aU approprialo label use dIrections and precautions lor the delolianls and inSOdicides.USO$f!: • 

NOTE: Under certain conditions, tank mixtures 01 PREpr.1 brand Ethephon with desiccants conlaining sodium chkVate Could • .,. ••• 

result in Iho lormation 01 hypochlorous acids which on heating will emil toxic chloride IUmes. • •••• 

EQUIPMENT CLEANING : .:::- •• : •• : 

Because 01 tho acidic naturO' 01 this product. prolonged exposure to spray deposil will damage acrylic plastics. setta!1) paint's: and 

motals. • •••• : 

Rin!!io thoroughly wilh a delergon! and water aU exposed acrylIC plastlc-type malerials (o,g., aircraft windshields). and painted surlacGs 

wIthIn an hour attor exposure to spray doposils. 

At the end of each day. rinse thoroughly wilh a detcrgont and water an the metal par1s 01 the aircral! and the associated spray 

equipment oxpo!!iod to Ihe spray deposits. 

102 
i 

COrtON 

USE 

PREp'nI 

8011 Opener· 

PREp1l( + 

FOLEX* 

IIx 

Tank 

Dropp2 

Defoliant Tank 

Mix 

Pre· CondItIoner 

for Defoliation 

EXPECTED 

CONDITIONS 

Hot and dry BO$F or 

higher 

Ory and 75 to iWF 

Cool but above 65°F 

m 

Rook ooHon 

High soil moisturo 

m 

High lortillty lovel 

m 

Rank ooHon 

High soil moistllfo 

High fertility level 

Rank cotton 

Hot, dry, above BO'F 

Cool, aboVe 65°F 

0< 

Rank colton 

1113 

2 

2213 

113 

113 

213 

I 1!3 

PREpni 

RATE 

rRE <J!, 

lBS A.I. Acr •• 

1.0 

1.5 

2.0 

0.25 

0.25 

0,5 

1.0 

6 

4 

3 

24 

24 

12 

6 

SPRAY VOLUME 

(GalslA) 

Air" 

2-5 

15·50 5 - to 

tS- 50 2-5 

·Pretreatment With Defoliants PrIor to PREp'fM Boll Opening Treatment 

APPLICATION 

TIMING 

Apply whon tho number of 

maturo unopened bolls is 

sulficionl to produce the 

desir&d crop. SIlO bolow for 

lost of boll maturity. 

Treatment uniformly opens 

bolls 7 to 14 days earUer, 

Apply 4 to 7 days prior to 

PREplM boll opening 

application. To bo used as a sequontlaltrealmen1 wilh, 

not i~~~I~~~9_.01 PREPni boll 

~ppl~ 4 10 '- d~y, p,jmlo 

" '.. -:~~ 

H the catton Is overly rank or laying down in tho middies and good spray coverage of the bolls with PREpTM is difficult, a pretroatment 

with dofoliams will be useful to improve boll covorago with PREplM, Use dosage ratos 01 PREpm brand Ethophon recommended lor boD 

opening. Read and ohsorve all appropriate label use directions and precautions lor tho defoliant used. / 

l In Galifornla and Arizona use a volume of no loss than 5 galions per acre tor aerial applications. V 

all Maturity . 

A boll is matum when it is too hard to bo dented when squeezed between thumb and fingers, too hard to be sliced with a sharp knife, and 

when the seod coat becomes light brown in color. .: • 

• Use Limitations • • 

Do not exceed a maximum of 2.0 lb. 3l/A torcombinod uses ot PREpl"Iol por aero per year. • •• • ••• 

BoD Opening: Do not tank mix PREpr>< brand Ethephon with a desiccant if tho cotton is to be spindle harvested. • .. . 

• ••••• 

• •• • • 

• ••••• • • 

•• 

Pre-Condition tor Detoliation: Do not tank mix PREP').! with desiccants unless planl dOSlccation is required, ~ ~J1So a dltrtfiM" 

bofore there is sufficient matu!& unopenod bolls to produce tho deshed yickl (soo GenerallnfOlmation sllClion on hq~ 10 tost'fMMIl 

maturity. •• • • • ... WHEN TO HARYEST COTTON • • ••••• 

• • 

•• 00 not harvGst ootton soontlr than 7 days after a trcalment with PREP'm brand Ethephon. : •••• • ••••• 

Observe tho treated crop and harvest whon optimum boll opening has boen reached. Too early harvest might roduc~ Me·tull advui.· 

01 tho troatment and too late a harvost may result in mduced quality and IoS$ of lint which will drop trom tho plant. ••• : •••• 

103 
PREplM 

Crop Situation Plnts/Acro 

1 113 

Over-The-Top 

Application 

1113-2213 

USE LfMfTATtONS 

50-60 

4O-SO 

TOBAeeO 

(Flue-Cured Only) 

Specllic Directions 

Uso drop nozzles. Chooso TG or DC spray lips designed to apply 50 

gpa at 35-40 psi and at tractor speod of 2-3 mph. 

2 the nozzles spray per to the row; loaves one 00 to each bo side ripened of fhe and rowdropped~:::,~:t~~;:2: harvested. I 

is essential. With Ii diroctlKi spray, be sure to harvost II 

1 

Treat only whon laavss remaining on the stalk aro 

remaining loavas are maturo, lost $pray soveral 10.1'''''0 

described undor the section ·Propor lime of Treatment." 

In a normally mature crop whon exporienco indicates that m:~~'~~: ~:'~~~ I indu~ment is required, Use Iho higher rate when the crop i 

a tendoncy 10 be more rank or when lemporalurl;Js are lower :.~~~~:~ I 

Always lost spray to delarmine if tho tobacco is mature enough to 

lotroatmonl with PREPn{ brand Elhephon. 

Apply over-the-top PAEprn brand Elhophon spray as a line mist using 

nozzles (one nonln tips over tho cenler of the plant, and ono on each 

so all leaves are covered , similar to the 

Do not apply PREp!'>! brand Ethephon to immature toaves as this can result in unsatisfactory coloring, waight loss and reduced leaf 

qual'llY. 

Do not allow the crop to ovar ripen in the lield alter using PREP(Y brand Ethephon, sinea this may cause somo lQduction in yield and 

quaJJty, 

Do not treat before anticipated major storm which could prevent harvest and resutt in crop loss. 

00 not apply PREJ>1M brand Ethephon if rain is t'Ixpocted within 4 hours. 

APPLfCATION TIMING 

Successful results with PREP'I"! calJ lor treatment when leaves are mature, not overly rank green when sprayed. To al15ily determine 

the proper trsatment timing and the number 01 leaves per 1$tall< roady lor harvest, tast spray sevsral planta in more than ono location in 

each field and observe the response. Malur& leaves will begin to yellow in 24 to 72 hours. Test leaves that fail to yellow in 72 hours are 

not ma.ture and are not ready for PREprn brand Ethephon treatment. Wait a IGW days to pormit 1urther natural maturing, then make 

her test spray or "maturity· check. 

hen you have confirmed the number 01 teaVQs per plant that will color. you can detormino the numbGr 01 acres to troat in order to till 

eOOm. 

Prepare your tast spray by mixing one toaspoon ot PREP1'" in t quart ot wator, Spray each tost plant with aboul t o. ot this mixture, 

covoring aU loavos wilh a rlflo mist. PREf>1"" bmnd Ethephon wiU not color immature sprayed teavos. .:. • ••••• WHEN TO HARVEST • • ••• 

AI) mature. sprayed I&avos wiU !>&gin to colOr wilhin 24 to 72 hours alter PREpw brand Ethephon application. Tho y\ll~~ proc:ss IS • 

weather dependent: cool weather will dolay, whHo hot, sunny weather can speod up the process. Harvest treat&d toba,co when';i.v,;; 

have reached the desired color lntonsity. ••• ... ••• ••••• 

Do not allow tobacco 10 bocome ovor ripe bolore starling harvest. loaf drop can occur whon tobacco is ovor ripe 1tnd\;it on th.~.· II a number ot tho bottom loaves have yellowed at the time of trsatment, they should be harvesled prior to spraying, f..it$'tRE pl'" brand 

Ethephon. ••• •••••• . ., With an over-thlHop application, harvesting can commence 24 hours aitor PREP'I'" brand Ethephon application de!lOnV\r90n weellf/l'r 

co~itions or to avoid ovor ripe tobacco, Tobacco harvosted 24 hours alter troatment will require more !fme in the ool~!n.srphasqef!tt!&: 

cUring process. • • • ••• 

CURING PREP"" TREATED TOBACCO ...... ! 

Curing procadures are as much an art as a science and each cure must be judged on the basis ot tobacco condition, interval between 

trealment and harvest, weather and type 01 curing facility belore prescription temperature and ventflation schedules can be 

established. To obtain maximum quaJity, care must be taken to observe and control the curing process closely, eSpGciaHy during the 

lale "coIOfing" and oarly "drying· stages 01 the leal. 

PREprn brand Ethephon Ireated tobacco will have started the coloring process when harvested, reducing Ihe time required in tho 

coloring phase 01 curing. Treated tobacco should be dried faster. If tobacco leaves are green or contain somG green when harvested, 

it may be nGCossary to color them lor a lew hours. Jllhe leaves are comp!rttely yol!ow.temperature and ventilation must be adjusled in 

a manner to dty tho tobacco as fast as possible w~hout scalding. Once the leal is dried (3/4 dry), you should lollow J'IOrmal procedures 

tor curing. Since PREpl">! brand Ethephan treated loaves cure taster, treated and untreated leaves should not be cured together in the 

samobam. 

104 

/ 
I ... 

LIMITED WARRANTY AND DISCLAIMER 

Tho manuf,acturorwarrants (a) that this product conforms to tho chemical description on the label; (b) that this product is roasonably fj{ 

for th& purposos sot forth in the directions fOr use when if is used in accordance with such directions; and eel that the dlroctions, 

warning and other statements on this label are based upon responsible exports' evaluation of roasonable tosls of effectiveness, 01 

toxicity to laboratory animals and to plants. and of residues on food crops and Upon reports of fiold experience. Tesls have not boen 

made on aU varieties or in all states or undor all conditions, THE MANUFACTURER NEITHER MAKES NOR INTENDS, NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES, EXPRESS OR IMPLIED, AND IT 

EXPRESSLY EXCLUDES AND DISCLAIMS ALlIMPUEO WARRANTIES OF MERCHANT-ABILITY OR FITNESS FOR A PARTICULAR 

PURPOSE. 

THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLElY RESPONSIBLE FOR, ANY AND ALL LOSS OR 

DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHfCH IS INCONSISTENT WITH THE LABEL 

DIRECTIONS, WARNINGS OR CAUTIONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, 

LOSSES, DAMAGES, OR INJURIES RESUlTING FROM THE USE OR HANDLING OF ll-IIS PRODUCT, WHETHER OR NOT BASED IN 

CONTRACT, NEGLIGENCE, SiRlCT LIABILITY IN TORT OR OTHERWISE SHAU BE LIMITED, ATll-IE MANUFACTURER'S OPTION, 

TO REPlACEMENT OF. OR THE REPAYMENT OF TIlE PURCHASE PRICE FOR, THE OUANTIlY OF PRODUCT WITH RESPECTTO 

WHfCH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL. INDIRECT OR 

CONSEOUENllAl DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT. 

NonCE TO BUYER 

Purchase of this producf does not confer any rights under patienls governing this product or the use thereof in countries outside of tho e United Stat os. 

_ 'DEF and Guthion are rogistorod trademarks of Bayer AG, Germany. ~ (e;, if"., ,,,.,, •. \ i \i_ .'! 1 2.,· 

I 

2Dropp is a registered trademark of NOR-AM Chemical Company. 

:lHarvade is a registered trademark 01 Uniroyal Company. 

~Malathlon is a trademark of American Cyanamid Company. 

RMno-Poukmc Ag Company 

P.o. Box t2014, 2 T.W. Aloxandor Drive 

Research Triangle Park. North Carolina 27709 

PREP is the tradomark 01 Rh6no-Poulenc. 

FOlEX is a registered trademark of RhOno·Poulonc . 

ACCEPTED 

wi1:h COM['.l1::NTS 

ill EPA I.cHef DMe<i: 

:\P(~ S ,(',("0 

'1, '-. t!~, i"'-CCr:-ll Ir-;~<ctl(de 

,J-,~, m)~ R0dcmic(;e Act 

-': -~dzd, kr the pesticide 

, ,}'~ :f"~ unc!er EPA F~g. No. 

9(";/ - '..i/ ~.' " ." ~- , 

PREpfM brand Ethephon tor Cotton and Tobacco (PENDING) Submitted 3122193. 

.,. • 

• 

• • 

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• ••• • . •• ,. 

• 

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• • • •• •• •• 

105 

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• 

• •••• 

• . ....... · . • 

••••• • • •• 
,------------------------ --_ ....... _---

• 

• 

Mr. Warren A. Davis 

Rhone-poulenc Ag Company 

P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, Me 27709 

Dear Mr. Davis: 

Subject: Add Use on Tobacco 

PREP Plant Regulator for Cotton 

EPA Registration No. 264-418 

Your Submission Dated December 7, 1992 

The amendment referred to above, submitted in connection with 

registration under section 3(c) (7) (A) of the Federal Insecticide, 

Fungicide, and Rodenticide Act (FIFRA), is acceptable provided that 

you: 

1. Submit/cite all data required for registration/-

reregistration of your product under FIFRA section 3(c) (5) or 4(a) 

when the Agency requires all registrants of similar products to 

submit such data. 

2. submit one (1) copy of your final printed labeling before 

you release the product for shipment. If these conditions are not 

complied withr the registration will be subject to cancellation in 

accordance·with FIFRA section' 6(e). Your release for shipment of 

the product bearing the amended labeling constitutes acceptance of 

these conditions. 

A stamped copy of the label is enclosed for your records. 

The additional brand name "PREplW Brand Ethephon for Cotton and 

Tobacco" is acceptable. 

Enclosure 

sincerely yours r 

Cynthia Giles-Parker 

Product Manager (22) 

Fungicide-Herbicide Branch 

Registration Division (H7505C) 

106 
• 

• 

Mr. Warren A. Davis 

Rhone-Poulenc Ag Company 

P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, NC 27709 

Dear Mr. Davis: 

Subject: Add Use on Tobacco 

PREP Plant Regulator for cotton 

EPA Registration No. 264-418 

Your Submission Dated December 7, 1992 

The amendment referred to above, submitted in connection with 

registration under section 3(c) (7) (A) of the Federal Insecticide, 

Fungicide, and Rodenticide Act (FIFRA), is acceptable provided that 

you: 

1. Submit/cite all data required for registration/-

reregistration of your product under FIFRA section 3 (c) (5) or 4 (a) 

when the Agency requires all registrants of similar products to 

submit such data. 

2. Submit one (1) copy of your final printed labeling before 

you release the product for shipment. If these conditions are not 

complied with, the registration will be subject to cancellation in 

accordance with FIFRA section 6(e).' Your release for shipment of 

the product bearing the amended labeling constitutes acceptance of 

these conditions. 

A stamped copy of the label is enclosed for your records. 

The additional brand name "PRE~llI Brand Ethephon for Cotton and 

Tobacco" is acceptable. 

Enclosure 

sincerely yours, 

Cynthia Giles-Parker 

Product Manager (22) 

Fungicide-Herbicide Branch 

Registration Division (H7505C) 

107 
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PRE P TM BRAND ETHEPHON FOR COTTON AND TOBACCO 

For Commercial Use Or Agricultural Use Only. Not For Residential Use 

ACTIVE INGREDIENT: Elhephon (2-Chloroefhyl) phosphonic acid" ........................................................ 55.4% 

..................... "., .............. , ...... , ................................................................. , .......... 44.6°4 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

PRECAUCION AL USUARIO: 51 uSlod no 100 inglos. no USG OSlO producto hasta que la informacion on la otiquota Ie haya sida 8xplicadc 

ampliamonfo. 

For MEDICAL And TRANSPORTATION Emorgencles ONLY Can 24 Hours A Day 1-800-334-7577 

For eRQ!>!!!,T J.!.S.C. Information Ca" ,·800·334·9745 

Tho use 01 this product lOT a variety of plant growth regulalion uses are prof.ctod by United States and loreign patonts includ[n 

U.S. Patents 38.791.188 and 4.240,819. No license is 9ranted to use this product in countries other than the Unked States or lor an 

use not contomplated by this labol. LiabHity for patent infringement may result Irom use or sale 01 this product outslde Ihe Unite 

States. 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EYES: Hold eyelids open and Ilush wilh a gentle stream of water for at loast 15 minufos. Get medical attention, preferably an 

ophthalmologist. 

IF ON SKIN: lmmediatoly wash skin wilh plonty 01 soap and water. Remove contaminatod clothing and shoos. Wash clothing 

separately before reuse. 

IF SWALLOWED: 00 not induce vomiting. Promplly drink a large quantity 01 milk, egg whites, gelatin solulion or if these are not 

available. drink largo quantilios 01 water. Avoid alcohol. CaB a physician immediately. 

IF INHALED: Removo vlclim to fresh air. II nor breathing, give artilicial respiration. Administer oxygen if neCGssary. Get medict;ll 

attontion. J 

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

CORROSIVE. Causes eye and skin damago. May be fatal if absorbed through SKin. Harmful if swallowed or lnhaloo. Avoid broathir.g 

spray mist. Do not get in eyes, on skin or on clothing. Wear full lenglh trousofS, long $leevod shirt, protective glovos, and goggles or 

tace shield when handling. Change to clean work clothes dally. Wash thoroughlywl1h soap and waler after handling and be/Ofe nUng, 

or smoking. Romove and wash contaminatad clothing belora reuso. Koop away from domostic animals. 

NOTE TO PHYSICIAN 

Thoro is no specific antidote. All troatmont shouk! be based on obsorved signs and symptoms 01 distress in the patlent. Overoxposut< 

10 materials othor than this product may have occurred. 

V"lCtlms 01 severe overexposure. by inhalation, should bo kept undoi' medical observation for up to 72 hours for delayed onsot 01 

pulmonary edoma. In a victim of over-exposure by ingestion. carolulgutric lavage is required duo to tho possibility of stomach or 

esophageal perforation. This materiaf is an acid, but use 01 alkaline sub$lancos to noutralize it}s contraindicated. 

ENVIRONMENTAL HAZARDS 

• • •• •••• 

• 

00 not apply directly to water, to aroas whero surface water is present or to intertidal areas below tho moan hifil wal.r mark. 

conlaminato water when disposing of equipment washwaters, : •• :.: •• 

• •• • Do not contaminate water used lor irrigation or domestic purposes. • • 

•••••• 

• • USE PRECAUTIONS • • 

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00 not apply PREprw brand Ethephon GoUon Boll Openor • •• through any typo of irrigation system .••••• • • 

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Do oot 

Avoid spray drift to nearby crops as this product will cause modificalions in plant growth. Plant IniQI)'P roducod ,lelds will result. 

00 nor plant another crop within 30 days alter troatmonl. 

Mix only the amount of spray you expect to use each day. 00 not allow mixod solution to stand ovornight. 

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DIRECTIONS FOR USE 

It Is a violation of Federal Law to us. thIs product In a manner Inconslstont wIth fl9 labeling. 

Road onUro label boforo usIng thIs product. 

REENTRY STATEMENT 

Mixors, loaders and applicators musl woar a full face shield, long trousofS, long sleeved shirt, glovos and boots to avoid as much skin 

and ova contact as possiblo. 

Do not enler treated fiolds within 24 hours ahar application unloss protoctive clothing is worn. 

STORAGE 

Do not contaminate water, food. or foed by storage or disposal. 

If contafnor is brokon or contents have spilfod, follow aD precautions indicated above and clean up Immediately. Boloro cleaning up. 

put on full length trousOn>. long slo~wed shirt, protective gloves, and goggles or laco shiold. Soak up spill w~h absorbent media such 

as sand. Garth or other suitable matorial and dIspose of wasta at an approved waste dIsposal facility. 

PESTICIDE DISPOSAL 

Pesticide wastas are acutely hazardous. Improper disposal 01 excass p&$ticide. spray mixture. or rins4te is ill violation 01 Federa! law. 

II these wastaS cannot be disposed 01 by us. according to lalrol instructions, contact your State Pesticide or Environmental Control 

Agency or the Hazardous Waste representative at the nearest EPA Regional Oltica for guidance . 

CONTAINER DISPOSAL 

Triple rinse (or equivalent) the empty containers. Then offer lor recycling or roconditioning. or puncture and dispose 01 in a sanitary 

!andlill, or b incineration or It a!lowftd b stato and local authorities, burnin If container is burned. sta out 01 smoke. 

GENERAL INFORMATION 

COTTON 

A loliar spray 01 PREpr!oI brand Ethephon will accelerate opening of mature unopened cotton bolls and enhance deloliation which can 

result in earGer harvest with an increased rocovorabl.e yield. PREP'I')I brand Ethephon treatment on cotton allows increased efliciency 

lrom a once-over harvest. 

TOBACCO {FLUE-CURED}: A loliar spray of PAEpnt brand Ethephon promotes &arly, uniform "yellowing- 01 mature Iobacct 

PAEpm roduco! curing timo, aI/owing moro efficient use 01 curing barn space, and increased control ovor haNGst schedules. 

SPRAY PREPARATION 

Add 112 to 314 of the required amount of water to tha spray tank. Stan agitation, Add the requIred amount 01 PREpru brand Ethephon. 

and the remaining amount 01 water. Prepare only as muCh sprOlY solution as can be used on the day of mixing, Do not allow spray 

solution to stand overnight. Do not spin the concentrat&d product on spray aquipment, or any airplane parts. 

ANY SPIUS SHOULD BE RINSED !MMEDIATELY WITH PLENTY OF WATER. 

Use 01 a nurse tank is highly recommonded lor avoiding possible spills 01 concentrated lormulation on spray equipment or any airplane 

parts . 

COMPATIBILITY 

PREpm brand Ethophon is compatible with DEFl, FOLEX®, DraW, Harvade:l· MethYl Parathion, Guthion \ and Malalhion4, and may bE 

awfiod in soquooce or as a taflkm((turo (DO NOT TANK MIX WITH DESICCANTS IF COnON IS TO BE SPINDLE HARVESTED). In 

some cases slight reduction in boU oponing respons.o has baon observed whon tank mixes with deloliants were used. 

Good agi1ation in the spray tank ia. essential and a tank mixture should not bo allOWed to stand without agitation lor more than 5to tl 

minutes, Read and obsorve all appropriate !abel use directions and precautions lor the defoliants and insodicides used. 

NOTE: Under cortain conditions, tank mixtures 01 PREpru: brand Ethepnon with daslccants contaIning sodium chlorate could 

rasun in the formation 01 hypochlorous acids which on hoating will emit toxic chloride fumes. 

EQUIPMENT CLEANING 

Because of the acidic nature 01 this product. prolonged oxposuro to spray deposit will damage acrylic plastifp. flti1"in paints, and 

motals. • 

Rinse thOroughly with a detergent and water all exposed acrylic plastic·type materials (e.g .• aircraft windshi"!i.).llpd painted surfacoE 

withIn an hour after exposure to spray doposits. : .. :.: ••• 

At the end of each day, rinse thoroughly with a detergent and water all tho motal pMs 01 tho arrcMh and the assoda!ed spray 

equipment exposed to the spray deposns. Ao:.:EPTED •• : •• : 

will> COMMENTS •••• 

In EPA Lcttl."f DtlIt.:d: ••••• 

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COTTON 

EXPECTED PREprw ONE SPRAY VOLUME APPLiCATION 

USE CONDITIONS RATE GALLON (Gals/A) TIMING 

PAEpnl 

TREATS 

Plnts/A LBS A.I. Acros Ground Air" 

PREprn Hot and dty SooF or 1113 1.0 6 Apply when the number 0: 

Boll Oponer- higher malUr; unopened bolls is 

01}' and 75 10 SO"F 2 1.5 4 15 50 2·5 $ulliciont 10 produco the 

doslrod crop. S&8 below lor 

Cool but 3lxwo 65GF 2213 2.0 3 tost 01 boll maturity. 

Treatment uniformly opens: 

Rank cotton 2213 2.0 3 bolls 710 14 days Garlier. 

PREpN + High soU moisture 113 0.25 24 15·50 5·10 Apply 4 to 7 days prior Ie 

FOLEX· High farli61y lovel PREpm boll oponlnf: 

Dofollant Tank Rank cotton 

application. To bo uslXl as 

Mix a soquontiaJ Iroatmont with, 

not in place 01 PREpN boli 

oponina treatment . 

PREpt'M+ Dropp2 High soil moisturo 113 0.25 2' to- 50 3·10 Apply .{ to 7 days prior te 

Dofollant Tank High lanility lovel PREpN boll oponing 

Mix Rank cotton application. To be used as 

a soquantial troatmont wnh, 

not in placo 01 PREPrw bol! 

oponinO treatmont. 

Pr.~Condltlon.r Hoi. dry. above BO"F 213 0.5 12 Apply 4 to 7 days prior te 

for Defoliation Cool, abovo SSGF 1113 1.0 6 15·50 2·5 doloUant. Enhances top 

crop dolollation raducins 

Rank CQlton 1113 1.0 6 doterioration 01 bottom crop 

and allows lor earlior . halVest. 

·Pretreatment With DefoUants Prior to PREpn! Boll Opening Treatment 

If the cotton is overly rank or laying down in the mlddlos and good spray coverage 01 the bolls with PREpm Is dilticult, a pretroatmen 

with detOliants will be uselul to improve boll coverage with PAEP~. Us. dosage ratllS 01 PREpm brand Ethephon Colton Boll Opener 

recommended tor boll opening. Read and obselVe all appropriato labol use diroctlons and precautIons lor tho dololianl used. 

""In California and Arizona use a volume of no lass than 5 gallons por aero lor aerial applications. 

Boll Maturity 

A boll 1$ mature when it is too hard to be dented when squeezed botNeen thumb and lingers, tOO hald to be slicod with a sharp knife, an, 

when Ihe seed coat becomes Ught brown in color. 

Use limitations 

Do not oxeood a maximum 01 2.0 lb. a'ilA for combined uses 01 PREpn.! por acre par yellr. 

Boll OpGning: Do not tank mix PREpt>I brand Ethophon with a desiccant if tho cotton is to be spindle haNosUt<i, 

Pro·CondltiOn for Defoliation: Do not tank mix PREpu.. with desiccants unloss plant desiccation is required. Do not use a delollan 

belore there is suHlciont mature unopened bolls to produce the dosfcod yiold (sea Gonerallnformation section on how to tost lor bo 

maturity. 

WHEN TO HARVEST COTTON • • •••••• 

Do not harvest cotton soon&!' than 7 days after a troatmont with PREpn.! brand Ethephon Colton Boll Opener.· 

ObSONO tho troaled crop and harvest when optimum boll opening has been reached. Too early harvost migh'reducI tho full advantagl 

01 tho troatmanl and too late a harvost may result in reduced quality and loss of lint which will dmp rr8~thQ ptant. •• • •• • • • 

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PREpnt 

Crop Situation PlntslAcro 

Dirocted Spray 11/3 

Application 

Ovar·Tho-Top I t/3-22/3 

Application 

USE LIMITATIONS 

tOBACCO 

(Flue·Cured Only) 

Spray 

Volume 

Gallons! Spoclflc Dlroctlons 

Acto 

50 ·60 Uso drop nozzles. Choose TG or OC spray tips designed to apply 50 • 60 

gpa at 35-40 p,1 and at tractor speed 01 2·3 mph. U .. 2 nozzles por row; ono on each side altho row dropped low enough 10 direct 

the spray 10 tho loaves to be ripened and harvesled. Thorough spray 

coverago is essential. WIth a directed spray, be sur. 10 haNas! alllGavos 

with 20% or more vollowina. 

40-60 Troal only whon leavos remaining on tho stalk ara maturo. To ensure 

romaining loaves aro maturo. test spray soveral tobacco plants as 

described under tho soction ·Propor Timo 01 Treatment.· Us. tho Iowar rata 

in a normally mature crop whon oxporionco indicateS that minimum ripening 

inducement \$ requiJed. U;.e the higher rata when tho cropfs heavy and has 

a tendency to be more rank or when temperalures are lower than normal. 

Always test spray to determine If tho tobacco is mature enough to respond 

to treatment with PREPn.t brand Ethephon. 

Apply over-the·top PREprw: brand Ethephon spray as a tine mist using throe 

nozzles (ono nozzla tips over the center 01 the plant, and one on each side) 

so all leaves are covered thoroughly, similar to the applicalion pattern 01 

systemic sucker controt agents. Use a soray prossule 01 40 to 60 ·psi. 

Do not apply PREPN brand Ethephon to immaturo leaves as this can resuft in unsatlslactory coloring, waightloss and reduced laal 

qualily. 

Do not allow the crop to over ripen in the field after using PREpnt brand Ethephon, since this may cause some reduction in ylold and 

quality. 

Do not treat boforo anticipated major storm which could provent halVost and rosult in crop loss. d 

00 not apply PREpnt brand Ethephon if rain is e)(pected within 4 hours. 

APpLtCA nON nMING 

Successful results with PREpnl call lor troatment whan loaves are mature, not overly rank green when sprayed. To easUy dotormin, 

the proper treatment timing and the number olleavas p&r stalk ready lor halVest, test spray several plants in more than on. location if 

each field and obselVe tho response. Maluro I&aves will begin toyoHow in 24 to 72 hours. Test loaves that fail to yellow in 72 hours ar, 

nol mature and are not ready for PREprw brand Ethephon treatment. Wait a low days to permit lurther natural maturing, then mak, 

another test spray or ~maturity~ check. 

Whon you havo conlirmGd the number olll!aves per plant that win color. you can determino the number 01 acres to troat in order to II 

tho barn. 

Preparo your test spray by mixing one teaspoons 01 PREPnI In 1 quart 01 water. Spray Ctach tost plant with abol1\ 1 oz. 01 this mixtur& 

covoring aU leaves with a lino mist. PREfmI brand Ethophon will not color immature sprayGd leaves. 

WHEN TO HARVEST 

All mature, sprayed loaves will begin to color within 24 to 72 hours aller PREpnt brand Ethephon application. Tho yellowing proctlss is 

weather depaooent; cool wealher will delay, w!J~e hot, sunny weathor can speed up th& process. Harvest treated tobacco when leave: 

havo reached the desired color intensity. 

00 not allow tobaCO') to bllCOme ovor ripe belore starting halVOSl Leal drop can occur when tobacco is OV8r ripe and loft on the stalk 

If a numbar of tho bottom leaves have yellowed at the time of treatment, they should bo halVest&d prior to spraying with PREP"N brat1( 

Ethephon. • • 

With an over-tho-top application, harvesting can commence 24 hours aftar PREpnoi brand Ethephon applicaKOnd;p.nding on woathe 

conditions or to avoid over ripe tobao:o. Tobacco harvested 24 hours after treatment will roqulro more time i.,.he coloring phaso olthr 

curing process. •••••• : •••• 

• •• CURING PREpn. TREATED TOBACCO : .: • 

Curing procedures are as much an art as a science and oach cum must be judged on the basi • .s:VJQQacco condition, intorval betweer 

treatmont and halVest, weather and typo 01 curing lacility belore prescription temperatureo ani ventilation schedules can b£ 

established. To oblain maximum quaUty, ca.ro must bo taken to abSOlVe and control tho curing prH&!I.$ clo$CI~. (lsp&cially during thr 

late ~coloring~ and early ·drying~ stages 01 the loa.f. ••••• • •• •• 

PREpni brand Ethephon Ireated tobacco will have slarted the coloring process when harvestod,~ tho limA requirad in the 

~Iorlng phase 01 curing. Trealod tobacco should be dried laster. If tobacco loaves are green or conlaln so$ 9MJl when halVastod. 

It may be nGCGSSary to colar thom lor a fGW hours. II the leaves are complelety yollaw. temporatura and vontil"atil:m*must be adjustGd in 

a manner to dry tho tobacco as fast as. possible without scalding. Once the klaf is dried (314 dry). you thould'(.now normal procedures 

lor curing. Since PREpThi brand Ethephon troatoe! loavos cure fastor. treatod and untroated loavos should rd b&.GUrad togothor in tho 

samo barn. 

111 
LIMITED WARRANTY AND DISCLAIMER 

Tho manufacturer warrants (a) that this product conforms to tho chomical doscription on tho label; (b) that this product is reasonably fi 

lor tho purpoSG$ sot taNh in tho directions for usa whon it Is used in accordanco with such diroctions: and (c) that tho- directions 

warning and olhor statements on this label ar~ based upon responsiblo exports' evaluation of reasonabf8 tosts of effectiveness, 0 

toxicity to laboratory animals and to plants, and 01 residuos on lood crops and upon reports of lIoki oxperience. Tests hava not boor 

made on all varieties or In all slatos or under aU conditions, THE MANUFACTURER NEITHER MAKES NOR INTENDS. NOR DOES n 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES. EXPRESS OR IMPLIED. AND n 

EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANTIES OF MERCHANT~A8llITY OR FfTNESS FOR A PARTlCUlAF 

PURPOSE. 

THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND ALL LOSS OF 

DAMAGE WHKiH RESULTS FROM THE USE OF nus PRODUCT IN ANY MANNER WHICH IS INCONSlSTENT WIlH THE LABEL 

DIRECTIONS, WARNINGS OR CAUTIONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS 

LOSSES. DAMAGES. OR INJURIES RESULTING FROM THE USE OR HANDUNG OF THIS PROOUCT, WHETHER OR NOT BASED It\ 

CONTRACT, NEGLIGENCE. SmicT LIABILITY IN TORT OR OTHERWISE SHALL BE LIMITED. AT THE MANUFACTURER'S OPTION 

TO REPLACEMENT OF, OR THE REPAYMENT OF THE PURCHASE PRiCE FOR, THE aUANTrrf OF PRODUCT WITH RESPECT TC 

WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL. INDIRECT OF 

CONSeaUENllAl DAMAGES RESUL TINa FROM TI-lE USE OR HANDLING OF THIS PRODUCT. 

NOTICE TO BUYER 

Purchase 01 this product does nol conler any rights under patienta governing this product or the use therool in countries outside 01 the 

Unltod Statos. 

e 'DEF and Guthion aro rogistorod trademarks 01 Sayar AG, Germany. 

2Dropp is a registered trademark. 01 NOR·AM Chamical Company. 

3HaIVadois a registered tradomark 01 Uniroyal Company. 

• 

4Malathion is a trademark of American Cyanamid Company . 

Rh6ne·Poul9nc Ag Company 

P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, North Carolina 27709 

PREP is the Irademark 01 Rhllne-Poulenc for Etheplion Cotton Bon Oponor 

FOLEX is a registered trademark 01 Rhone·Poukmc. 

PREpN brand Ethephon lor Cotton and Tobacco (PENDING) Resubmitted t2l7/92. 

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112 
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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D C. 20460 

CHICEOF 

"'l[VtNT'ON. PE5T,cIDES 

I<NO TOXiC S'Jssr"'M:€S 

Mr. Warren A. Davis 

Rhone-Poulenc Ag Company 

P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, NC 27709 

Dear Mr. Davis: 

Subject: Add Use on Tobacco I ~ ! 0,1"~ (" !A'-~r PREP Ethephon <"'Cotton Bo±l-Opener 

EPA Registration No. 264-418 

Your Submission Dated December 7, 1992 

The amendment referred to above/ submitted in connection with 

registration under section 3{C) (7){A) of the Federal Insecticide, 

Fungicide l and Rodenticide Act (FIFRA) I is acceptable provided that 

you: 

1. Submit/cite all data required for registration/-

reregistration of your product under FIFRA section 3(c) (5) or 4(a) 

when the Agency requires all registrants of similar products to 

submit such data. 

2. Submit one (I) copy of your final printed labeling before 

you release the product for shipment. If these conditions are not 

complied withl the registration will be subject to cancellation in 

accordance with FIFRA section 6{e). Your release for shipment of 

the product bearing the amended labeling constitutes acceptance of 

these conditions. 

A stamped copy of the label is enclosed for~ your records. 

/ Sincerely yours, 

Enclosure 

d " ~_/~~~7, 

r~ Jr' ~ , ~ /"~~7~ - 1:."1 ~ _/g,~jC_ 

'-", ~/-'/ 

Cynthia GrleS:parker 

Product Manbger (22) 

( Fungicide-H~rbicide Branch 

Registration Division (H7505C) 

113 
" 

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, , 

ti!!, RHONE-POULENC 

RHONE·POULENC AG COMPANY 

December 7, 1992 

U. S. EnvIronmental Protection Agency 

Office o( Pesticide Program Document Processing Desk 

Room 266 A, Crystal Mall No, 2 

1921 Jefferson Davis HIghway 

ArlIngton, Virglnja 22202 

AttentIon: Mr, JIm Stone 

Registration Team (22) 

FungicIde HerbIcide Branch 

RegistratIon DivISion (H750SCJ 

Dear Mr. Stone: 

RE. Prep brand EtrlephCn For Cottor. ana Tobacco 

EPA Reg. No 264-·1 i 8 

In your letter oated November 30, i 992 a request was made to add the statement "Do not 

apply directly to '.vater, to arezs wr\ere surface water Is present or to inter Udal areas 

below the mean hlgh w3terlT'ark" '.'Ie are Including 5 COpies of amended labels wlth th15 

statement addeo. 

InaddHlOn a completed offer to pay form uSing the cite all wethod of support is appended 

The only reg1strant listed in the most recent EPA mdex of data submItters 15 GAF 

CorporatIon. They shOuld De deleted as a regIstrant (or ethePhQn since ljtjgatlon In the eariy 

1980's resulted In a court Judgment that all ethephon prOduct inventOrJes and data were the 

sole property of UnIOn Carbide Corporat lOn, now Rhone-Poulenc AS a result no offer to pay 

were actually sent to support thIS aDplicat10n. 

VIe need this label approval very quickly to_ o'iOidd printing and DacKagmg delays (or the 

1993 season. To expedite approval. we are faxing to your toaay a cooy of the cover letter, 

one label and the completed oHer to pay. By over night delivery servIce we will send 5 

amended labels, and the Original or(er to Day. 

'We apDreclate your aSSIstance 1n this 1rr,porta!'lt regIstration lssue. If you have any 

Quest ions please contact Jr,€' prompt 1, (919-5-19-23791 

Sincerely. 

{j)~A~ Warren A DaVIS 

SenIor Reg1strat Ion r13flager 

POBOX IC;H~ 2 rW .... l.£XAN[)ERcqiVE 

RESEAACH lFi'ANGLE PARK NC 277m 

{\j19)549·2QOO 

.NTEP.NAlIONAl TELEX Nu~-.!eER 4!n937!J -ANS'NERSACj( APC flTr 

:NfERNAHON,I.l DISTRISUnQN SERVICES T£L0: NUMBER 4999217 -ANSWERBACK Arc iDS 

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CERTIFICATlOO w:rm RESPECT 'In CITATIOO OF MTA 

EPA File Symbol/Reg. No. 264-418 "'te of 400licadcn __ 1.:0_-2,,6.:-..:.9..:.2_ 

Name of Product PREP ETHEPHON CottO" Boll Opener 

Aoolicaht • s N.-ne and Address ___ Rc.h.:.on;..e;..-_P-,o.:".:.l e:.:n ... c'-'-A.:;:9_CO_'..:,'p_a_":;.Y _____ _ 

P. O. Box 12014 

Research TrjangJe Park. NC 277Q9 

1. This application is supported by all data autmitted or cited in the 

application. In addition, if cite-all options are in:1icated, this application 

is suoported by all data in the Agenc::y's files that concern the properties 

or effects of this product or of I1tV other product that is identical or 

substantially similar ~ and that is one of the types of data that 'oIOUld be 

required to be submitted if this application sought the initial registration 

of a product of identical or shafler composition and intended uses under 

the data: requirements in effect on the date of approval of this apr>lication. 

2. I certify that. for each study cited in support of this application 

for registration that is an exclusive use study, I have obtained the 

vritten permission of the original data submitter to cite that study. 

3. I certify that, for each study cited in supoort of this application 

for registration that is ~ an exclusive use study: 

I have obtained the written petmission of the original data submitter 

to cite that study: .2!. 

I have notified in writilYJ the ~nies who have sut:rnitted rJaU I have 

cited. to suotX)rt this application and have offered to: (a) Pay ~nsation 

for those data in accordance with section 3{cHl){O} and 3{c)(2HO) of 

the Federal Insecticide, Fungicide and Rodenticide Act; and (b) Cc:nmence 

neqotiat.ions to detetmine which data are subject to the o::mpensation 

requirement of FIFRA and the II'BOWlt ard ,tenns of canpenntial due, if 

any. 'nle ~nies I have notified are: (O)eck ale) 

[Xl All ~nies listed on the Pesticide DIU Sul::rnitters List for 

all active irqredients oontained in my product (Cit .... all methoo: or 

cite-all option urrler selective Method). (Also sign the General 

Offer to Pay Statement below.) 

[1 'Iboae cx:rtq;)anies WhO have subtlitted the studies '«<lim I have 

cited (Selective methOO) 

Date 12-17-92 

Title Senjor Registration Manager 

• ••••• 

General Offer to pay; I hereby offer and a:;rrfte to pay c:anpens4i ctt:to 

other persons, with Agard to the ap\X'oval of thiS applicatiorf, to "the 

extent req\Jired by FIFRA Me. 3(c)(1)(0) and 3(c)(2)(0). ..: •• : 

j • " "". ) ••. ." 

Dote 12-17-92 Sianature .1/"--'Qa",. /I I./'i¢>."", 

Title 

EPA Form (April 19851 

• • ••••• Senior Registratjon Manager 

• • •••••• 

• 

•• • •• • 

• •• 

• 

••• • •• •• • 

• 

• •• •• • •••• 

. , . . ' . · " 

115 
~---------------------------------------------

• 

• 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D,C, 20460 

OFPC~Of 

PHtoVO<TION. ?;::5TiCmES 

""",0 TOXJ::: SUUSfA.NCCS 

Mr. Warren A. Davis 

Rhone-Pou!enc Ag Company 

P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, NC 27709 

Dear Mr. Davis: 

Subject: Add Use on Tobacco 

PREP Ethephon Cotton Boll Opener 

EPA Registration No. 264-418 

Your Submission Dated October 26, 1992 

Prior to approval of the new use, you must comply with Title 

40 Code of Federal Regulations Part 152 Subpart E - Procedures to 

Ensure Protection of Data Submitter's Rights by choosing either the 

cite-Allor selective Method of Support. Please note that under 

the Selective Method for this product, you must submit a Data 

Listing of all product specific and generic data required by 40 CFR 

Part 158 since this product does not qualify for the formulator's 

exemption. For each data requirement, you must submit or cite an 

appropriate study or document that a data gap exists. 

We have no adverse comment on alternate brand name and the 

revised labeling except the Environmental Hazards statement should 

be updated to include the following statement: 

Do not apply directly to water, to areas where surface 

water is present or to intertidal areas below the mean 

high water mark. 

We are holding the labeling in our files for this product 

awaiting resolution of the above issue. 

sincerely yours, 

•• •••• Cynthia Giles-Patkdr 

• • •••••• 

• 

... 

. , . · .. 

• 

ProdUct Manager f~':2) ...... 

Fungicide-Herb~c1dQ Brancfi 

Registration oi.,.i:aion (.e:7~95C) • • 

• ••• 

116 
• 

• 

RHONE.POULENC AG COMPANY 

DeC(~rrber 7, 1992 

U S Envlr )rIMer·tal protectIon Agency 

Off1ce of ~'estlclde Prograrr Doc.ument ProceSS\f1g DeSk 

Room 266 p." Crystal f"iall ~iO. 2 

1921 Je~(~rson D3\I[5 HIghway 

Arlington, Vlrgln!a 22202 

Alt.ntlor" Mr, JIm Stone 

ReglstraUon Teoam (22) 

Funglclde HerbIcIde Brartch 

Aeg1strat on Dlvls ton (H750SC) 

pn·p Dralid EtrepilOn Fe,;, Cotto"18M TObaCCO 

EPA Reg No 26<4-1118 

In y::,~r letter Mtec ~·;i)veJjlbS'{ 3(;, 1992 a t?Q"esr v,'as rn;':l')t' t:) aed t>e statement 'C-o riot 

app~y dIrectly to v.,atf'r, to 2'c35o vihN~ Sifface water'$ Vesent or tC' !r~terl1oal areas 

below tM rr.ear'l hj~l water rra"'k" Vi:? 2te i'1Clv:1f19 S cODies 0f arc ended labe!s- with thls 

statement added 

!rl a-j::il~lor a :orr.pie'ed off€', to pa,! for"'G us!rlg,th'? c;te a;\ "!le-t:-:oc of support IS appended 

"f"h£, Oil"" r{'9istrar,~ 11st£'o ';, tne most recer,t E:JA jr.,ji.'i', c" tja~;) SI;C0',ltters 15 GAf 

(O;Do,atlon ·:-htV shouid Le oelHE'G as a regiSF<F,t (or e-ti)epbct. sir';:e 1!!igat1ofl in t'lr: early 

1980's reSl.n',ej I;, .:: (('lIt j'Jr:g"f'1;0t ttla~ 31 j Bt:'lep:-,:'f! pro,juc: In''t-r.~o;~es arid data wf±:'e VHf 

sole D:oDert/ cf i,:rdo", Carbide Cornc("atI0f,. r,ovi R"jOf1e-POiJle:::: AS a result roo offer to pay 

'JvF'(> ;:H..~tuij~1) $f:r1~ t'J $'",P()(lr-: ~hjs 21pDlicat lon 

\ve ;ieeo tr,ls l~lt.\I?l a;:;or'>.'o31 ")':/,y 'J\..!Ci\;Y to 2h'ofcd !:,:-j~,:ll)g and pa>:zgmg oe:ays for t'le 

1993 seas)',; To e;.;pedlte oprro\.'al, we ore fa!!):'g to yew toj~y ZI COPy or tl'e cover leUer, 

O~ie 'ab~i (j:rl'::! t .... .; cO'Y'pleted oqH to ;:'21'1' ::!y ov~- ;-,\gN del~'jer/ servIce vH: W 111 send 5 

aTE'ilded !nbels, zrj:he- 0' \9!(la; C,rri!f ~c pay 

Wi: ZlJi:re: at~ ),0'1- assistance jf> V'ls 'FQ0rtc'lt ~fg~stn.}~I·):' iSS!.):>, '{ yO'J nave 1'1'1/ 

qJ;:st iOG5 })\,eas~ ':('~' toct ty e prOi0pt 1,; (9-', g- 549-237";)'1 

S lflc~rel)', 

WOMM' 

Warren A. DaVIS A~ 

!i 
fRO}1 r_>,£_"o'J]"[" :<';' ,:~.-£q",;:; 

~ t1-'y'w';-rVLlI.l:~,~;;<"J: _____ """ ___ "" _____ ""_""_."" __ 

• 

r 

Rt{ONI.I'OULENC Afl COMPANY 

ENVIRONMENTAl., REGULATORY u l'lJl!L1C Al'l'A!ltS PEI'ARTM£l','T 

PO So, 12014,2 TW Aleundtr Dtlvo 

R.....,ch Tlia"Sl. Park. N,e. 21109 

FlU( Numbor. (9)9)549.2545 

fAX COVER SHEET 

UlIGnm k::" YES __ NO DATl!: n; 2 1'/'-

'fO: ..L-,'S ... b!Jil.,l;ryt'~ ______ FAX NO, '703 - 30 It - I if 2 S 

FlIOM:.Ja.L1~ tl j D4I', l> 1I!.El'HONl!NO, 9/9-.>vQ-A,,>,? 

'TOTAl NUMBER OF PAGES (lNCLWlNG THIS SH!ETJ: ______ _ 

--------------~~~----------------

____________________ ~M~E~S=SA~G~~~· ___________________ _ 
• 

• 

• 

2~1- ff g UtUL ••• .. • .. 

• • • • • • • • • • .. ... .. • , • • • • • • 

• • • • • 

• • • • • • 

• • • • PREpTM brand Ethe"phon FOR COTTON ANt> TOBAt3Co • 

• 

For Commercial Use Or Agricultural Use Only. Not For Residential Use 

ACTIVE INGREDIENT: Elhephon (2·Chloroelhyl) phosphonic acW , ... ,' " .... , ... . 

INERT INGREDIENTS: " .. "" ................ " .......... ,,, .............. , 

"This product contains 6 pounds elhephon per gallon. 

, .... 55.4% 

.... , .44.6% 

EPA Reg. No. 264-418 EPA Est. No. 264-PA-01 

KEEP OUT OF REACH OF CHILDREN 

DANGER PEUGRO 

Si usled no entiende la etKjuela, busque it alguien pala que se la explique a usled en delalle 

(If you do nol understand the label, find someone 10 explain illo you in detail) 

For M;..QlQAk And IBANm:QBIAIlOl! Emorgencles 9..tl..1"Y Call 24 Hours A Day 1-800"334·7577 

. ______ ~, ________ ,f2::e!391>J,l..9J~~~~~ CaB,,!:,!~~y~~~G-!i-.:~92"2937) __________ _ 

The use ot this product ter a variety of plant growth regulation uses aM protected by United States and foreign patents mcluding 

US Patent 4,240,819, No license is granted to use this product in countries olher lhan the Ulliled States or tor any use not 

£q!1~!!!p'~ated by this label Uabikty tor patent intringement may result tram use or sale ot this producLoutslcie the United States 

FIRST AID c_ -,- -'- -~'--'----',----------------------- -----------~- -------------_' __ I : If IN EYES: I. Hold eye open and rinse slowly and gently with water tar 15·20 minutes. i 

1 :. Remove contact lenses, it present, allerUle first 5 minutes, then continue rinSing eye_ 1 , , I 

J __ n ________ ,_l.~ __ £all a e..~QllS:~)ntr'9! center or doclo0'.2r~~advit:..e... ____ ----------------1 : If ON SKIN OR 1_. Take off contaminated clothing. : , l CLOTHtNG: :. Rinse slon immediately wilh plenty of water for 15-20 mmutes_ i , I I 1 __________ J~_9!I~oJ.!iQ_~ control ~r doctor for IreatmenLadVlce, _____________________ ! 

~ IF SWALLOWED: i. Immediately call a poison conllol cenler erdoctor for lreatment advice. \ 

1 ! I I I. Do not induce vomiling unless lold 10 doio by a poison control center or doctor I 

I l :. Havepersansipaglassofwateritabletoswallow. ! 

l __________ .L~_Qp_ not gillS anything by mouth to an unconsciQus pers£.n _________ _ 

I - 1 

I For MEDICAL Emergencies Call 24 Hours A Day 1 "BOO"334~7577, I , ' L ____ Have th'tEroduc!..£QD!~ror labet with you when call1ngll polson control centcr or dEctor or g0!n9191_trel1!'!lOnt!.. ____ ~ 

! NOTE TO PHYSICIAN: Treat symptomatically, Consideration should be given to the pOSSIbility tnal ollerexposure 10 materials I 

: other than tllis product may have occurred_ No specific antidote is ttvailable Probable mucosal damage may contraindicale the use ! ~,E!.2.a~,'!1£...!!l!'!9!l ______ ,_ ~ __ , _____ , __ ~ _____________________________________ ,~J 

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

CORROSIVE Causes irreversible eye damage and skin bums Harmtu! if swallmved or absorbed through skirt Dc nct get in eyes_ cn 

skill or on c!ollnng, 

PERSONAL PROTECTIVE EQUIPMENT (PPE) 

Applicators and otner handlers must wear coverallS over short-sleeved shirts and short pants, chemical resistant gloves made of any 

waterproc\ matenal (such as Nilnle, Butyl, Neoprene <lf1dior Barrier laminate), cnemiC<llI-resislant footwear plus socks, protective 

eye'l.-'ear, chemical-resistant headgear tor overhead eXposure and chemlcal·reslstant apron when doanmg equipment or mlxir.g and 

loadmg 

119 

... • • • • • • • • • • 
• 

• 

••• •• • • • • • • •• • • • • • •• • •• • • • • ••• • • • 

D!scard clothing and other absorbent materials that have been drenched or heavily contaminated with this products concentrate. Do 

not reuse them Fonow manufacturer's instructions for cleanlngimaintajning PPE. If no such instn;ctiollsJor washabl,¥, use detergef\l .... . . . and hel water, Keep and wash PPE separately from QUler laundry. • • • • • • : : 

lNhen handlers use dosed systems, enclosed cabs, or aircraft in II manner that meets the reqwements..'Isied in the ~~&:er Pr~tect¢ln: Standard tVVPS) for aglicultural pesticides {<lO CFR 170240 (d) i4-6)J. the handler PPE reqUirements may be reduced ~r modified a\ 

speCified in the WPS 

User Safety Recommendations 

Users should wash hands before eating, drinking. chewing gum. uSing tobacco or using the tOtlet. 

Users SllOUId remove clothing immediately if pesticide gets inSide. Then wash body thoroughly and put on clean clottling. 

Users should remove PPE Immedialely after handling Ihis product. As soon as possible, wash thoroughty and change inlo clean 

dothmg Wash the outside of gloves before removing. 

ENVIRONMENTAL HAZARDS 

Do not apply directly 10 waler, or 10 areas where surface water is present or 10 intertidat areas below the mean high water mark Do nOI 

rontammale water when disposmg of e<:/uipmentwashwaters. 

Do not contaminate water used for irrigation or domestic purposes 

SPRAY DRIFT 

Avord spray drift Do not appty when weather conditIOns may cause drift Do not allow thm product to drift on to non-target orcas Drift 

may r€!Sutt III illegal residues or iniury 10 ad/acent crops and vegelation, in the form of leaf yellowmg and defoliation. To avord spray 

drift, DO NOT apply aerially when wind speed is greater than 10 mph or during periods of temperature inversions. Use of larger droplet 

$Ile will also reduce spray drift. 

AVOtDtNG SPRAY DRIFT AT THE APPUCATION SITE ISTHE RESPONSlBtLlTY OF THE APPLICATOR 

The interaction of many equipment-and.weather-related factors deterrn:ne the potenllal for spray drift The applicalor is responsible for 

considering aN these factors When maKing decisions, 

The lollowmg drift management requirements must be follcw~ to avoid olf-Iarget movement ftom aeriat applications to agricultural fleW 

creps These requirements do not apply to forestry applications, public health uses or 10 applications using dry formulations. 

1 The distance of the ouler most nozzles on the boom must not exceed 3/4 the length of the wingspan or rotor, 

2 Nozzies must always pOint backvlard parattelwilh the air stream and never be pointed downwards more tha1l45 degrees 

Where states have more stringent regulations, they should be observed. 

The ~pplicator shOUld be familiar with and take into account the jntorm~tion covered in the Aenal Dnft RedUClion Advisory below 

AERIAL DRIFT REDUCTION ADVISORY 

[ThiS section is adviSOry in nature and does not supersede Ihe mandatory labet requirementsj 

INFORMATION ON DROPLET StZE 

The most effective way'to reduce drift pOlenlial is to apply farge droplets The best drift managemem strategy is to apply the largest 

drcpfets that provide sufficient coverage and control. Applying larger droptets roouc@s drift potential. but will not ptevent dnlt If 

applications are made improperly, or under unfavorable environmenfal wnditions (See Wmd, Temperature and Hum;aity, and 

T t'!mperalure Inversions/. 

CONTROLLING DROPLET StZE 

Volume· Use high flow rate nontes to apply the highest practicat spray volume Nozzles with higher rated nows produce larger 

droplets. 

Pressure - Do nOI exceed the noule manufac(ure(s reconlmended pressures, For many nozzte types lower pressure produces larger 

droplets. \NIlen higher now rates are needed, use higher flow rale noutu instead of increasing pressure. 

Number of nozzles· Usc the minimum number of nozzles that prOVide Uniform coverage. 

Nozzie Orientation - Onentlng nozzles so that tile spray is released paraliel to the airstream produces larger droplels than other 

orientations and is the recommended pr(lc\ice. Significant deflection from horizontal wilt teduce droplet size and increase drift potential 

NOllfe Type. Use a nozzle type thaI Is designed for the intended applicallon. With most nozzle types, narrower spray angles produce 

I(lrger droplets. Consrder USing low·drift nozztes. Solid stream nonles onented straight back produce the targest droplets and the 

lewest dnft 

BOOM LENGTH 

For scme use pattems, reducing the elfective boom lenglh to less Ihan 3f4 of the wIngspan or rOIDr length may further reduce dntt 

Without reducing swath Width 

120 

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• 

• 

APPLICATION HEIGHT 

Applications shOuld not be made at 3 height greater than 10 leet above the top of the target ptants unless a greater height is required 

for aircmft salety. Making applications at the lowest heighl!hal is sale reduces exposure of droplets to evaporation and wind 

SWATH ADJUSTMENT 

lNhen applications are made with a crosswind, lhe swa!h will be displaced downwind. Therefore, on the up and downwind edges of the 

fiefd, the applicator should compensale for this displacement by adjusting Ihe path of the aircraft upWind. Swath adjus!ment distance 

should increase, with Increasing drift potential (higher wind, smaller dropS!, etc.) 

WIND 

Dnft potential is lowest between Willd speeds of 2 ~ to mph. However, many factors, including droplet siZe and equipment type 

determine dnft potential at any given speed Application should be avoided belOW 2 mph due to variable wind direction and high 

Inversion potential. NOTE- Local terrain can infiuence wind patterns. Every applicalor should be familiar with local wind patterns and 

how they affect spray drilt 

TEMPERATURE AND HUMIDtTY 

When making applications in lew relative humidity. set Up equipment to produce !argerdroplels to compensale for eVaporation. Drop1e! 

evaporation is most severe when conditions are both hot and dry. 

TEMPERATURE INVERSIONS 

Appflcations should not occur dUflng a temperature inversion because drift potenlial is high. Temperature inversions restrict vertical air 

mixing, WhiCh causes small suspended droplets to remain in a concentrated cloud, This cloud can move in unpredictable dit"ections due 

10 tho: kght vanable windS common during inversions. Temperature inversions are Characlerized by Increasing temperalures with 

altitude and are common on nighls with limited cloud cover and fight to no wind They begin to form as the sun sets and often cantinue 

Inlo Ihe momlng_ Their presence can be Indicated by ground fog, however, If fog is not present, Inveralons can also he identified by the 

movement of smoke from a ground source or an alrcralt smoke generator. Smoke Ihat fayers and moves lalerally in a C(lncentraled 

cloud {under loW WlOd conditions} indicates an inversion, while smoke that moves upward and rapidly dissip3tes indicafes good vertical 

au mixing. 

SENSITIVE AREAS 

The pestlcide should only be applied when the potential for drift to adjacent sensitive areas (e g. residenUal areas, bodies 01 waler, 

known habitat for threatened or endangered speCies, non-target crops) is minimal (e.g. when wind is blowmg away Irom the sensilive 

areas.) 

USE PRECAUTIONS 

00 not apply PREp-ru brand Ethephon for Cotton and Tobacco through any type 01 imgatioll system 

AVOid spray dnft to nearby crops as this product will cause modllications in plant growth. Plant irljury or reduced yields will result 

Mix only the amount of spray you expect to use each day. 00 not allow mixed solution to stand overnight 

DIRECTIONS FOR USE 

It is a vlolntlon of Fodcrallawto uso this product In a manner Inconsistent with Its labeling, 

Do not appty this product In a way that will contact workers or other persons, either dlroelly or 1hrough drift. Only protected 

handlors may be in tho area durlng apPlication. For any requirements speclnc to your State or Trlbe, consult1he agency 

rosponslble for postlclde rogulatlons. 

Read entire labol befoTO using thl$ product. 

AGRICULTURAL USE REQUIREMENTS 

-Use ihis product only in accordance with its labeling and with the Worker Proteclion Standard, 40 CFR part 170. This standard contains I reqUirements for the protectIOn of agncultuml workers on farms, foresls, nurseries, and greenhouses, and handlers of agricultural 

pesticides. It contains requiremenls for training, decontamination, notification, and emergency assistance, It also (:ontams speCIfic 

Instructions and exceptions pertaining 10 the slatements on this label about personal protective equipment {PPE), notlficalion to workers 

and restricted..enlry mtCfVals, The reqUirements in thiS bOll: only apply to uses of this product that are covered by the Woriler Proteclion 

Standard 

I DO not enter or aliow worner entry IOtO treated aress dUring the restricted-entry mlervsl IREI) of 48 hours. The REI IS 72 hours in areas 

_where average rainfall is less than 25 indles per year_ 

PPE required for early entry to treated areas that is permitted under the Worner Protection Standard and tha1 involves conlact with 

anything that has been lreated such as plants, soil or water Is coveralls over long·sleeved shirt and fong pants, chemical reSllltant 

gloves made 01 any walerproof material, such as nlln~, butyl, neoprene, or barrier !aminate, chemical resislant footwear plus socks, 

"nd protective eyewear. For overhead exposure, chemical-resislant headgear is also requited. 

l~Ellfy workers of the application by warning Ihem orally and posllng warning signs at entrances to ~rea!,,'~d,."ree'e'c· ________ 1 

121 
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• 

STORAGE AND DISPOSAL 

00 not contaminate water, food, or leed by slorage or disposal. 

PESTICIDE STORAGE 

Store In a ceol, dry place and away from food, feed and other pesticides, IF SPILLED: If container is broken or contents have spitted, 

follow all precauuons indicated above and clean up immediately, Before cleaning up, put on fun length trousers, tong sleeved 51))r1. 

protectNe gloves, and goggles or face shield Soak up spill wHh absorbent media such as sand, earth or olher suitable malerial and 

dispose of waste al an approved waste disposal faCility, 

PESTICIDE DISPOSAL 

Pestclde wastes are acutely hazardous Improper disposal of e~cess pesticide, spray m!xlure, or nnsate is a violation 01 Fe<.!erallaw If 

these wastes cannot be d~posed of by use according 10 label instructions, contact your State Pesticide or Environmentat Control ! Agency or the Hazardous Waste representative at the nearest EPA Regional Office for guidance, 

CDNTAINER DISPOSAL 

Tnple rinse (or equlValenl) the empty conlainers. Then olfer for recycling or reronditioning, or puncture and dispose ot in a sanrtary 

landfill, or by mClflemlion or If allO'Ned by stale and 10CitI authorities, by burning tf container is burned, stay out of smoke, 

RETURNABLE -- REFtLLABLE CONTAINERS 

After use, return the container to the point of purchase or designaled Iccalioll$ This container must only be refilled with PREp1" brand 

Ethephon for Collon and Tobacco, DO NOT REUSE THE CONTAtNER FOR ANY OTHER PURPOSE. Prior to refilling. Inspect 

thoroughly for damage such as Cfacks, punctures, abrasions and damaged or wom out threads on closure deVices. 00 not rellli or 

transport damaged or leaking con tamers. Check for leaKs after refilting and before transportation If the container is not being ref~led, 

~turn It 10 the point of purchase 

GENERAL INFORMATION 

COTTDN 

"lohar spray of PREP'" brand Ethephcn for Cotton and Tobacco wJI accelerate opening 01 mature unopened cotton bolls and enhance 

defotiatlon which can result In eartier harvest With an increased recoverable yietd PREp .... brand Ethephon for Cotton and Tobacco 

treatment on cotton attows incmased efficlImcy from a once-over hSNe;st 

TOBACCO (FLUE-CURED): A foliar spray of PREpw brand Ethephon for Colton and Tobacco promotes early, uniform "yellowing" of 

mature tobacco PREptU brand Ethephon fer Cotton and Tobacco'reduces: cunng lime, allowing more efficient use of curing barn 

space_ and increased coutrol over tlarvest sct\e{!ules 

SPRAY PREPARATION 

Add 1/2 to 3,'4 of the required amount of water to the spray tank Start agi(.;ltion Add the required amount of PREp!" brand Ethephon 

for Cotton 3nd Tobacco, and the remillmng amount of water Prepare onty as much spray soluHon as can be used on lhe day of mixing. 

00 not allow spray sotution to stand overnight. Do not spill the concentrnted product on spray equipment. or any airplane parts 

ANY SPILLS SHOULD BE RINSED IMMEDIATEl Y\N1TH PLENTY OF WATER 

Use of a nurse tank is highly recommended for avoiding possible spills of concentrated fOlmutahon on spray equipment or any airptane 

parts 

TANK MIXTURES WITH DEFOLIANTS AND tNSECnCIDES 

PREP'" brand Elhephon for Cotton and Tobacco is compatible With DEFe, FOLEX®, Dropp''', Dropp® Uftrn1>.l, Gmstare, Harvadel!l, 

Methyt Parathion. Guthionc, and Malathion. PREP'" brand Ethephon for Cotton and TObacco may be aWlled in sequence or as a tank 

mixture (DO NDT TANK MIX WITH DEStCCANTS IF COnON IS TO BE SPINDLE HARVESTED), Follow alt applicable use 

precautions and rate per acre recommendallons on labels of products apptied as tank mixtures or In sequence with PREP 1" brand 

Etnephon lor Cotton and Tobacco. In some cases slight reduction in boll opening response has been observed when tank mixes with 

defoliants were used. 

GoOd agi1a~¢n in the spray tank 1$ essential and a tank mixture should not be allowed to stand without agitation for more than 5 to -::0 

minutes Read and observe all appropnate label use directions and pre\:au\iOns for the defoliants and insecticides used" 

NDTE: UNDER CERTAIN CONDIT10NS, TANK MtXTURES OF PREptu BRAND ETHEPHON FOR COTTDN AND TOBACCO \N1TH 

OEStCCANTS CONTAINING SODtUM CHLORATE COULD RESULT tN THE FORMATION OF HYPOCHLOROUS ACtDS WHICH 

ON HEATtNG WILL EMIT TOXIC CHLORIDE FUMES, 

DO NOT MtX PREP'" BRAND ETHEPHON FOR COTIDN AND TOBACCO WITH AMMONIUM THIOSULFATE SUCH TANK 

MIXTURES MAY RESULT IN FORMATION OF TOXIC FUMES, 

eau IPMENT CLEANING 

Because of the acidiC nature of this product, prolonged exposure to spray deposit will damage acrylic plastics, certain paints. and 

metals 

122 
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I 

Rinse thoroughly WIth a detergent and water all exposed acrylic plast/o--type malerials (e.g" aircrall windshields), and painted surfaces 

wIthin all hour after eJo(posure \0 spray deposils. 

At the lind of each day. rinse thoroughly with a detergent and water all the melal parts of the aircraft and the associated spray 

equipment exposed to the spray deposrts 

COTTON 

USE EXPECTED PREpIM BRAND ONE MINIMUM SPRAY APPLICATION 

CONDITIONS ETHEPHON FOR GAllON VOLUMES TIMING 

COnONAND PREP"" {GalsJAl~ 

TOBACCO BRAND 

RATE ETHEPHON 

FOR 

COTTON 

L 

AND 

TOBACCO 

TREATS 

PInts/A LBSA.I, Acros Ground Alr"~' 

PREP'" brand Hoi and dry 80"F or 11/3 1.0 6 Apply when the number of 

ETHEPHON FOR higher 

I 

mature unopened haUs IS 

COTTON AND Dry and 75 to BO"F 2 1 5 4 5ufficienl 10 produce Ihe 

TOBACCO 10 2 desired crop. See below for 

8011 OPCntlr"' CoOl but above 6S"F 22/3 20 3 test 01 b~1 maturity 

Treatment uniformly opens 

" boll$ 7to 14 days earlier. 

Rank colton 

PREpI'M brand High soil moisture 113 0.25 24 to 5 Apply 4 to 7 days prior to 

ETHEPHON FOA " PREp'N brand Ethephon lor 

COTIONAND High tertlilty leve! Collon M' Tobacco boll 

TOBACCO + i opening applicalion To be 

FOLEX$ 0' ",ed sequenlial ., , Defoliant Tank Rank cotton trealment with, not in place 

MIx'- ot PREP"'" brond Ethephon 

for Cotton and Tobacco bel! 

ooenina treatmenl. 

PREpm brand High soii moisture 113 0.25 24 10 I 3 Apply 4 to 7 days pflor to 

ETHEPHON FOR " PREpru brand Ethephon for 

COnONAND High fertility level , Collon a"" Tobaccc boll 

TOBACCO + Oropp ! opening applicalion, To be 

" Defolianl Tank used sequential '" , 

Mix"· Rank COItOIl 

I 

treatment with, nol in place 

, of PREp'N brand Ethephon I for Colton and Tobacco boll 

ooenlnG treatment 

Pro-Conditloner Hot. dry. above 213 05 12 

I 

I Apply 4 to 7 days prior to 

Itor Defollallon BO°F 1 tl3 1.0 6 10 2 defoliant Enhances top 

Cool, above 65"F I crop defoliallon reducing 

" , I delerioralion of boltcm crop I I and allows for earlier 

Rank colton harvest . 

• For best performance_ by ground or air application, chOOSe eqUipment and spray volumes that wJ!llnsure uniform coverage of foliage 

and bolls, 

•• Protreatment With Defoliants Prior to PAEpTM brand Ethephon for Cotton and Tobacco Boll Opening Treatment: 

If the colton is overly rank or laying down 10 the mlddte'S and good spray coverage of the bolls wilh PREpm brand Elhephon for 

COUM and Tobacco IS dl(fjcult, a prelrealment With defolianls w'tll be useful to improve bol! coverage wilh PREpru brand Ethephon 

for Colton and Tobacco Use dosage rates of PREpm brand Ethephon for Colton and Tobacco recommended tor boll opening 

Read and observe all appropriate label use directJons and precautions for the defoliant used . 

•• , Can use up 10 full label lale for eilch product 

.... In Callfom!a and Arizona use a volume of no less than 5 9",lIons per acre tor aerial app!icallons 

123 
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Boll Maturity 

A boll is mature when It is too hard to be denied when squeezed between thumb and fingers. too hard 10 be shced wllh a sharp kmfe, 

and when the seed coat becomes tight brO' .... n in color, 

Use Limitations 

Do not cxceed a maximum 01 20 lb. elhephon active ingredient per acre per year through combined or repeated uses 01 any 

ethephon products 

Boil Opening' Do not tank mfl( PREP'" brand Ethephon lor Collon and Tobacco with a desiccant it the cotton is to be spindle 

haNested 

Pre-Condition for Defoliation 00 not tank mix PRE plIO brand Ethephon for Collon and Tobacco with desiccants unless plant 

desiccation IS rcquired Do no! use II defoliant before IlWtre is suffiClcnt mature unopened bolls to produce the desired yield (see 

Generallnformalion scdlon on how to test for boll matunty. 

DO NOT APPLY PREP'" BRAND ETHEPHON fOR COTION AND TOBACCO IF RAIN IS EXPECTED WITHIN 6 HOURS_ 

Rainfall within 6 hours of application may reduce product performance. 

Do not plant another crop wllhln 30 days after treatment. Small grains plaflted earlier than 1 month or inlercropped with the cotton 

crop to which PREpm brand Ethcphon for Cotton and Tobacco wdl be applied may only be used as cover crops and may not be 

harvested fcr food or feed PREP"'! brand Ethephon for Cotton and Tobacco may cause yellowing and growth inhibition of treated 

smaU grains. 

WHEN TO HARVEST COTION 

Do not harvest cotlon sooner than 7 days aller a trealment With PREP'" brand Ethephon for Colton and Tobacco. 

Observe the trealed crop and harvest when optimum boll opening has been reached. Too early harvesl mtght reduce the full advanlage 

olthe treatment and too late a harvest may resull in reduced quality and loss oflmt which will drop from the plant. 

Crop Situation 

Directed Spl3Y 

Appllcahon 

Over-The-Top 

Applicaticn 

, PREpr'" brand 

Ethophon for 

Cotton and 

Tobacco 

Plnts/Acro 

1113 

I 11!3-22f3 

USE LIMITATIONS 

TOBACCO 

(Flue-Cured Only) 

Mlntmum Spray 

Volumos 

Gallons! 

Acre 

50 

40 

Spocffic Directions ! 

I 

Use drop noutes_ Choose TG or OC spray lips designed !o apply 50 - 1$0 

spa at 35-40 psi and at tractor speed of 2-3 mph Use, 

2 nozzles per row: one on each side of the row dropped low enoogh to direct ! 

the spray to the leaves to be ripened and harvested. Thorough spray I 

coverage Is essential Wi!h a d'lrected spray, be sure 10 harvest all !eaves I 

With 20% or more Yellowing. 

Treat only when leaves remaining on the stalk are mature. To ensure 

remaining leaves are mature, test spray severa! tobacco plants 35 descnbed 

under the MC'lion "Proper Time of Treatment" Use the lower rate m a 

normally mature crop when experience indicates that minimum r!pening 

inducemenl is required, Use the higher rale when the crop is heavy and has I a lendency to be more ranK or When temperatures are lower than normal 

Arnays :e5t spray to determine If the tobacco is mature enough to respond I 

to treatment with PREP'u brand Ethephon for Colton and Tobacco . 

Apply over-the-top PREP"" brand Ethephon for Cotlon and Tobacco spray I as a tine mist ·using Ihree nozzles (one nozzle tip over the center cr the 

plant, and one on each skle) so all leaves are covered thoroughly, similar to 

the application pal\em of systemic sucker contrOl agents. Use iii spray 

I pressure 0140 to 50 psi, 

Do not apply PREPru brand Ethephon for Cotton and Tobacco 10 Immature leaves as this can result In unsatisfactcf)' colonng, 

Vlelght loss and reolJc-ed leaf quality 

Do not allow the crop to over ripen In the fieid after using PREpm bmnd Ethephon for Cottcn and Tobacco, since Ihis may cause 

some reduclion In yield and Quality 

Do not treat belore anticipaled major storm which could prevent harvest and resull in crop 10$5. 

DO NOT APPLY PREP'''' BRAND ETHEPHON FOR COTTON AND TOBACCO IF RAIN IS EXPECTED \MTHIN 6 HOURS 

RainfaH wdhin 6 hours of application may reduce product performance, 

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• 

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00 not use PREP"" brand EthephOn for Cotton and Tobacco with addiUves other than recommended on this label 

00 not planl another crop within 30 days after treatment 

00 not exceed tl maximum of 2 tbs ethephon active ingredient per acre per year through repeated uses of any ethephon products. 

APPLICATION TIMING 

Successful results with PREP"" brand Ethephon for Colton and Tobacco call fOf treatment when leaves are mature, not overly rank 

green when sprayed To easily determine IIle proper treatment timing and the number of leaves per stalk ready for h'If"csl. test spray 

several plants in more than one location ill each field and observe the response. Mature leaves wilt begin to yellow in 24 to 72 hours, 

Test leaves thai tail to yellow In 72 hours are not malUre and are nol ready for PREP'''' brand Elhephon for Cotlon and Tobacco 

treatment Wait a few days 10 permit further nalurat maturing, Ihen make another test spray or "maturity" ched<-

To .wold qva1ity toss and or poSSibte leaf drop, harvest any yeHowed teaves prior 10 apptication. Use tower rates under most condllions. 

tlmll use of higher rates to coot (below 65F at the time of treatment) slow ripening conditions 

When you have ecnfirmed the deSired number of !eaves per ptant that wilt cotor, YDU can determme the number of acres to treal m order 

10 fililhe barn 

Prepare your test spray by mixing one teaspoon of PREP'" brand Ethephon tor Colton and T obaceo m 1 quart of water. Spray each 

lest ptanl With about 1 oz. of this mixture, covering alt leaves with a fine mist. PREP'" brand Ethephcn for Colton and Tobacco witt not 

color immature sprayed teaves 

WHEN TO HARVEST 

All matvre. sprayed leaves will begin to ector WIthin 2410 72 hours atter PREpm brand Ethephon for Cotton and Tobacco apphcallon 

The yellowmg process is weather dependent. cool weather wilt delay, white hot, sunny weather can speed up the process. Harvest 

trealed tobacco when teaves have reached the desired color intensity 

Harvesl can commence 48 hours after PREpm brand Ethephon tor Colton and Tobacco appliClllion. To delermme harvest timmg and 

aVOid quality t05S or teaf drop, ctosely monitor trealed crop and weather condllions. 

CURtNG PREptIA BRAND ETHEPHON FOR COTTON AND TOBACCO TREATED TOBACCO 

Curing procedures are as much an art as a science and eaCh cure must be Judged on the basis of tobacco condition, inteNat behveen 

treatment and haNest weather and type of Cllting laci~ty before p~scription temperature and venlitalion:schedules can be estabHshed, 

To Obt2lln maximum quahty, care must be taken to obseNt' and controt the cunng process cIosety, especially during the tate "coklrlngIT 

alld early ~drying" stages of the teaf. . .i. _ i Til f';'~ ,; '\! 1 ~/ 

PREP"-' I;rand Ethephon for Cotton and Tobacco Ireated tobacco .wlll have st(lrted the cotoring process when haf\'ested. redUCIng the 

lime required in the cotonng phase of Ctlring. Treated tobacco shoutd be dried faster. tf lobacco teaves are green or contain some 

green when harvested, it may be necessary to CQlor them tor a few hours. tf the leaves are comptetety yellow, temperature and 

venlltat\on must be adiusted in a manner to dry the tobacco as fast as possible without scatding Once the teaf is dried (314 dry). you 

shoutd follow normat prOcedures for cunng. SlI'Ice PREP'''' brand Ethephon for Cotton and Tobacco Irealed leaves cure faster, trcaled 

ana untreated leaves shoutd nol be cured fogether in the same barn 

NOT REVIEWED 

In Accon:b.nce With PR Notice 82-2 

Based on Draft Labeling Dated 

//- :l."f- ~"o.2. 

125 
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, . 

IMPORTANT: READ BEFORE USE 

Read the enUre Directions for Use. ConditJons, Disclaimer of Warranties and Limitations of LiablJily before using this product If terms 

are not acceplllbJe. return the unopened product container al once. 

By uS!I1g this product, user or buyer accepts the following Conditions, Disclaimer 01 Warranties and Limitations of Liabmty. 

CONOITlONS: The directions for us.e of this product are belie .... ed to be adequate and should be followed cateftJllj'. However, it is 

impossible to ellminate all risks associated with the us.e of this product. Crop infury, ineffectiveness or other unintended consequences 

may result because of such factors as weather condl\lon8, presence of other malerial$, or the manner of use or application, all of which 

are beyond the control of Bayer CropScience, All such risks shall be assumed by the user or buyer. 

DISCLAIMER OF WARRANTIES: BAYER CROPSCIENCE MAKES NO OTHER WARRANTIES, EXPRESS OR IMPLIED. OF 

MERCHANTABIUTY OR OF FITNESS FOR A PARTICULAR PURPOSE OR OTHERWISE, THAT EXTEND BEYOND THE 

STATEMENTS MADE ON THIS LABEL No agent of Bayer CropScience 1$ authorized to make any warranties beyond those contained 

herein or to modify the warranties contained herein. BAYER CROPSCIENCE OISCLAlMS ANY LIABILITY WHATSOEVER FOR 

SPECIAL, INCIDENTAL DR CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANOLING OFTHIS PRODUCT. 

UMITATIONS OF l.IABIl.ITY: THE EXCLUSIVE REMEDY OF THE USER OR BUYER FOR ANY AND ALL LOSSES, INJURIES OR 

DAMAGES RESULTING FROM THE USE OR HANDliNG OF THIS PRODUCT, WHETHER IN CONTRACT, WARRANTY, TORT, 

NEGLIGENCE, STRICT LIABILITY OR OTHERWISE, SHAll NOT EXCEED THE PURCHASE PRICE PAID, OR AT BAYER 

CROPSCIENCE'S ELECTION, THE REPLACEMENT OF PRODUCT . 

NET CONTENTS: 2,5 GALLONS 

Dropp, Glnstar. Def and Guthion are regislered trademarks and Prep and Ultra are lrademarks of Bayer, 

Folex is a registered trademark of Arn .... ac Chemical Corporal'lon . 

Harvllde is II registered trademalk of Uniroyal Company. ' 

Malalhum is a trademark of American Cyanamid Company. 

Bayer CropScionce LP 

P.O. Box 12014, 2 T.W. Alexander orivo 

Research Triangle Park, North Carolina 27709 

1-866-99BAYER (1-866-992-2937) 

PREpTII brand Ethephon for Cotlon and Tobacco {MASTER) Approved 11/27/02. 

126 
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• 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON. D.C. 20460 

Mr. Warrel'l A. Davis 

Rhone-Poulenc Aq Company 

NOV 30 1992 

P.O. Box :L2014, 2 T.W. Alexandor Drive 

Research 'rria.ngle Park, NC 27709 

b.'/r Hr~ 1)'IVi.: 

Subjeot: Add Use on Tobacco 

PREP Ethephon Cotton Boll Opener 

EPA Registration No. 264-418 

Your Submission Dated october 26 1 1992 

orflCt01 

I'AMt{f1O!'(, PESfICIOE& 

,v.o ro)(IC lIVaslANCU 

Prior to approval of the new use f you must comply with Title 

40 Cod. Oj~ Federal Regulations Part 152 subpart E ... procedures to 

Ensure Pre,teotior\. of Data Submitterf s Rights by ohoosing either the 

cite-Allor Selective Method of Support. Please note that under 

the Selective Method for this product, you must submit a Data 

Listing of all product specific and genoric data required by 40 eFR 

Part 158 "ince this product does not qualify for the formulator's 

exemption. For each data r$quirem~nt, you Dust submit or cite an 

approprial,e study or dooument that a data gap exists. 

We have no adVerse comment al ternata brand name and the 

revise4 labeling except the Environmantal Hazards statement should 

b& updated to include the following stat'amant: 

Do not apply directly to water I to areas where surface 

water is present or to intertidal areas below the mean 

hiqh water mark. 

We at's holding the labeling in our files for this product awaiting resolution of the above issue.. 

Cynthia Giles-parker product Manager (22) 

Fungicide-Herbicide Branch 

R"gistration Division (H7505C) 

127 
• 

• 

EPA File S'/lIIbOl/ltOo. No. 264-418 OSte of aQ1:)1icaeion 

Boll Opener 

10-26-92 

_ Of Ptlx1uot PREP ETHePHON Cotton 

~l1ca'nt' n Nane al"Kt ~rH. __ ...:;;Rh~o::;n:;:e..;-P..;o:..:u:.:.l ::;en~c:...;.:A.::.g ..;C:,:o;,;ffi::.pa;;n;,:y _____ _ 

P. O. Box 12014 

1. 1!ti. epplicotion il II\Ip\:OI:ttd by all data lumittod or eittd in the 

appliettion. In tddition, it oite-ell optiona a,. iooi06ttd. thi. oppllo .. ion 

it IUpPOrte' by all data in the 1\0.",0)". fil .. that oonoarn tha propIrti .. or effectS ,~ thil croduet or ot' aJr( other pr<:duct that ia i&ntlcal or 

.uMtantially .!milar. an<! thot i. ona of the typ;tB of data that ..,wd be 

requitod to be luhmitted if th!. oppllcotion oooght tha initial rtgistration 

of • produc, of identiosl or .!milar _ition an<! intsOOtd utel under 

tile data .... j\J'''''''''nts in .ffeot on the date of approvel of this eppllettion. . . 

2. I oo,ct.!fy thot. for Noh study cited in Il.lpIX>rt of th!. application 

for rogilU1ttion that is an exclusive liM Itudy, t haW' obtained t~ 

written perraitsion of the orloinal data sut:tniteer to cit. that atlXSy • 

3. X 0I1~ifY that t for •• ch .tudy cited In &UPP;:!rt of thi. application 

for reQiatrlltion that i. !2t an exclusive \1H Itt.dYf 

I hav. (li)taiMd thO' written pormiulon of the original datA lumltttr 

to eit. that atudYf 2t 

I he"'. rotified in 'lfritin:; the ~nl.1 Who haN. aul:::fnltted rSau I have 

cited tc:, .uccort this application and MV$ offerod tot (,1 pay CXl'I1"!naation 

for thoa. data In acoordanoe with aeotlon llcHl}(D) and 31eHZHDl of 

the h<Jeral I .... otloide. IImJlcide and _tloida Act, ond Ibl o:mnonoe 

n.ootiation. to detemine which data an: subject to the ~nsation 

t'eqlJ.irtll'l.nt. of 'InA an.;! W !I!OJnt 400 terms of ~nutic::n due. if 

any. Tht ~ni," t have ootitied ar&t (Checlc. ant) 

[Xl ,Ul oarpani •• Hated en the PQdcide Data Sulrnitters Ust for 

all b:etivo i1'lQt"tdients. contained in Tfq product (Ci~l tMth~ or 

cl ..... ll option under 9&lective MothodJ. (.yeo 'Ign the Go!)!rA1 

.2ll!!: to Pay BY'","",nt belQ!l.1 

t 1 ~l't'loM ~i .. whO ha:ve .uan1ttod th_ nu61., •• which I have 

cited 19&1ectlve ... thodl 

Dat. ~'-17-92 

Date ...li-17-92 

Blgnloture ~ tl: Dod",% 

1'1U. . SeDlpr RegiHcHiQP J:jlnjlger 

I hereby off .. and ...- to pay _nAtion to ~~,~ to tha approval ot thl. application. to tile 

""". 310){1)(01 """ 3(c)(2)(01-

SLqnat_ dJA['¥4,,,,,. A= .00..<;";' 

Titlo Sanier Ragistration ManAger 

{!\Pdl Ins J 

, . 
, s 

PREp T

," BRAND ETHEPHON FOR COTTON AND TOBACCO 

For CommercIal pse Or Agricultural Use On IX. Not For ResIdential Use 

ACTIVE INGREDIENT: Elhephon 12·Ch!oroelhyl) phosphonlc acid' .. "."." ... "" .... " .. " .... "."."" .... " .. " ..... 55.'.% 

INERT INGREDIEN.,.S: """.'" .... "" .... "" .... """" """ ... , ..... " , .. "" ... "."" """'"'' ""'" "" ................... ".44. &% 

'ThIS WUfl conlaln. ~ pounds erhaphen per gallon, 

EPA Reg. No. 264·4111 EPA eat. No. 264.PA:.!1.lKEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

PRECAUCION AL USUARIO:Sl uSlad no lOG Ingles, no us/) Gsl& produClO hasla. C{uo Ie In!ormaclon an la eHql.lota 10 haya sldo o:.:pHcado 

amp!l.monto. 

For MEDICAL Alld rBANSpOBUTrOtl Emera.nol •• ONLY Carl 24 Hour. A Day 1-800.334.7&77 

For Information Call 1·800·334·9745 

he U$G 0 I is pro \.Ie! or a venaty 0 anI growth reg;;la! on uses are protected y n ed latos and ore gn patents nduding 

U,S, Palonts 38,191,188 llf:d 4,240.8t9. NO' 11000$9 !, glarrt~d to utO Ih1& plodU¢t In counulos other than tho United Slalos or for any 

Utili flO! contlmplaltd b, this labaL liability lOr pat&r.t inlringGmont may tesult from uso or uJe of this product outside the Jnhod 

.tatllS. 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EYES: Ho:d W&llda open ard tlush w~h a g'!'lt~a s\leam ot wator tor atlea~ lS m\nU'&$, GGt mod(eal a1\a1'l~ion. preiel&btl an 

oph:halmologlst, 

IF ON SKIN~ Immediatol, wash skin w;',11 plenty of soap a!'-o water, ROn'.oVG contamlna\od olothlng and IIhoo!i, Wash clothing 

tepalstElly bofote reUse, 

IF SWALLOWED, 00 n~tlndue. vomi:!ng, Prompfy drti'lK a lorgo quantity of milk. GOO whltat, QGtat:" sotut:On or It thou are not 

I1vellab!a, drink largo QUBlltiti9$ of water, Avoid alcohO'I, Call a phYSician ImmQdic~oly, 

IF INHALEO: Romov. v.ctim to !ro!lh air. If not bt03tl)ing, gtvt arillicial fGsp:ratlon, Admlnls:ot oxygen if naCfssary, Gat medical 

allentlon, 

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

CORROSIVE, Causes eye and skin da'1'1&go. May bo ilit$.: II ab-sorblXllh'Qugh skin, Harmful II swallowed Ot Inhaled, Avoid broaH:ng 

e ay mls\. 00110\ get in iyes, on skin or on clothing. Weal to/Ii length iroU$8IS:, long sllllGved shirt, protective glovQs, and goggl-u ot 

e shleld when handling. Coange to clu.-"l work dothGS daily. Wash thoroughly with soap and watet after handfrl1iJ and bEifOla SAling, 

Of&mok!ng, Remoye and wash conta1'llnat&d clo~!'-!ng befolQ rause. Keep away from do:nestic animals, 

NOTE TO PHYSICIAN 

Thore 1$ no spoclflc MtldNe. Ali troatmGr.! shoiJld bG based 0') cbnI'Vfld sigr>; and symp10ms 01 dhulGU In tho patiQrtt. Overoxf=osur. 

to matorlals other than Ihh product may have OCCUIIOd, 

Victims- ot Javor. ove(exp-~.I.;r., by IlihalaHon, should 00 kOPl under mi:HcaJ obsorvailon tor up \0 72 hours for dolayed ontot ot 

pUlmonary &<fllma. In a ";dim of over-exposUfo by 1"\18$tion. C91elul g<)&lrlc-Iavag& IS requlrod due to tlto possibUHy of Gt-omach o· 

esophagul perforation, Th;1I mat!)lfa! i& an acid, bt.t USI) ot a!kallna substan<:&s to M(.Itrnfiz$-1\ Is CQn~ralndlcai9d, 

ENVIRONMENTAl. HAZARDS 

Do not apply dl.Gctly to waitt, to areas where sJ!lace- wa!"r IS pruent or to :r!llH'lidal area$ be\ow the mean high water marK 00 nut 

contaminate waler when elspo#lng of oqulpment wt\$hwalqrt, 

Do not contamlnato wat&r uscd fOI btlgation or dom&slic purpO$$l, 

USE PRECAUTIONS 

Do not npp-Iy PAEp1'Io! brar,d Elhophon: Colt01 BoH Opener through any tyiXl' ol1rrlQat1-on ;YSt9:n. 

Avoid &pray drl, 10 naarby crops as th:s p~oduct wi!: causa modificaF::ns in plant I)lo',',1n, Plan! InjJty or reductd yields will resull, 

00 not plant anothor OIOP w1:hin 30 days aftor wumnen!. 

Mix Olifytho- amount of &Pfl:lY you expeCl to us-a oach da'l, 00 no! aliow m:Xed .wlution to eland overnight 
It I. 8. vlo!a!!on 

DIRECTIONS FOR USE 

of Fedor.1 l.aw Ie u.t thl. produot In a manner Inoon,latont with 

Rnd tnUre !abo! before uDlng thl. product. 

REENTRY 8TA"{EMENT 

, , 

na labo!lng, 

Mb:ers, loadors- end app!lC.10f. musl WUI a IvU face shiojd, lOng Irousors, long ,!(lOyed a.hl(l, gloves and boots to avoid., much skin 

nfld eye oonla.ct a8 pass ble, 

Do not enler tr •• tod noldJ wilhln 24 hOUfS altor appl'ICAlIOn unless prOiGCI!vo clothing Is worn, 

I~;~~;~,· oo~~n.~tamlna!. WalOf, food, or toed by $!olag9 or d!sposal. 

conlalnor Is broken Of conlon!, hayti' spWtd, fo!:Ow a!i procat.liol1s lnd£atod above and clGan up immodlate!y. Bejo:o cllUlnlng ,Jp, 

on full length trovsots.long sloaved shirl. pt1)!GC!Iv., gloves, and gogg' •• or fac. ahiold. Soak up sp:U wilh absorben! med:a such 

und, eann or Other $~ hable matfYlal and dispose of waSle tI! an approvod watfe dlspollal fac:lii)'. 

I ~!~~~:~~I~:; DISPOSlIl I~ ! wastos arllllOJlotf ha::ardOU$. Improper dispeaal 01 flXCGli pntk:-cde, 'pray mlxturo, or rln5810 !s .. violation of Fedora! law • 

. !hesa wastos cannol bf disposed o! by use according to fabol !nslruct!otHi. OOnt3Ct your Stale Pestlctde or En,,:ronmental (:<)nlrol 

or thl Hazardous Waste ropretOr'ltslNO atlho noarl)s! EPA Reglonat Olfjca for guldanct-. 

GENERAL INFORMATION 

COTTON 

II !' I or and a tafli!ary 

A foliar spray of PREpN t,ra:1d EthephCn wm acce!&raIQ oponlng 01 maturo Urlop&l)&d cotton boEs and onharv» da!oHatioi"l which eM 

result In earHer haN9st with an !ncrollsed rocovirabfQc y;okL PREPtl-I brand EH.opllon trulment on colton aKows Increased o!fjcl(mcy 

from a on<»..o".r h,,,,,,osl 

TOBACCO (FL.UE~CUAED}: A fol,lar sprey 01 PAEPTl{ brand Elhophon promotes early. uniform ')'ollowlng· of mafure !ot,acco, 

PREp1).( r&duon curing !:IT!G, allowing mOl. ufficiont usa of cJrinQ barn spaCQ. and InctU$&d conko! O'l&r harvost 'chodulu. 

SPRAY PREPARATION 

Add 1/2 to 3r4 oft\;& requIred amount ot wattr to thO' spray !a!'\k Start aQhatlon. Add tho r.q'.lirtd aMOunt of PREpno brllf'ld Ethophon. 

and lhe r.malnlng: amount of walliH. Propare only as much Gpray SOlution fl' can biJ used on tho day of mixing. Do not atlow 'pray 

solution to stand oVtrn!aht. Do not spl!! tht conconlratQd product on ',pray equIpment Of afrj ahplane parts, 

ANY SPILLS SHOVLD BE RINSED IMMEDIATELY WITH PLENTY OF WATER 

Use of a nutsotank Is hlOltly (Gcommondod for avoidir<9 pouibl& sp%. of COXllnltalGd for<Tlu!allon on spray oquipmon! or any alrj:·fano 

pans. 

·.MPATIBILITV 

EPlll: brar'od Ethephon ii compstibio wllh DfF', FOLEX3 , Drop;l. HaNMo3• Mothyl Parathion. Guthion1, and Malalhk.m4, and msy be 

apptiod in uquenceor as 11 tank Mixture (00 NOT TANK MIX WITH DESICCANTS !F COTTON IS TO BE SP!NDLE HARVESTED). to 

!>oma CUG9 slight roductittl'l in bol,: op&n!ng r.upon" hlt~ baGn obsorved when lank rnbHII!I: wi!h dGfoliants were ueod. 

Good agltaHon In the 'prf_Y tank It Gssunllal a1d til tank ml:<ture should nol b. a.llowed to IIllInd wi:hout &OII9.I;on for more Ihan 5to 10 

m;nutO$. Road and ob •• rvo all approprial~ labal Ul!iG direc110ns Mel precau!lons for !he dolol!an!s and !nsoctlcldes usod. 

NOTE: Ur.dor cortaln O<tnd1lionG. lan% mixtures of PREPn; brand ElhOpr.on w:th desfocants contaIning lIodlum chlorale could 

r.sult in !he form.!bn of hypcCh!OfOU$ ac~ds which 01'1 Maling wHl omll loxlc chlor1do fumos. 

EQUIPMENT CLEANI'IG 

&caus. o! !he acidic nat!lrG o! Ih19 product. prc-longiJo 9;O:poSU!$ to spray doposlt wi\) damaQe acryliC pfasl'iCS. certain paInts, and 

meta". 

Atnsa !horoughly with a d"tergenl ano waler a~! ox,POsod ac,),llc p!SSI-i:-lypo malarlals (e.g., alrcrall windshields}, and paInted su(acos 

wlfhln an hour alter ~Xj::OBur9 to splay capoal!s. 

At the end of .ach day, rinse thorovghly with a dotorganl and waltH atltho metal pariS of !hll airel e.!! and tho usoc!ated spray 

oquipmont oxposod to the spray deposils. 

130 
•• .............. -· .................... ~c~(5~T~fp,()~Nr" ................................ ..... 

USE 

PREp'IlI 

Boll Openar' 

PREPni + 

FOLEXc 

Oofollanl Tank 

Mix 

Oropp' 

Tank 

Ix 

Prl~Condltlon.r 

for Oafonatlon 

EXPECTED 

CONDITIONS 

Hot and dry OO"F or 

tlghq, 

OJ)' and 75 to WF 

1113 

2 

0:>01 but above 6S"F 2 2/3 

H·gh sol! moisl'Jr~ 

Hgh lGinHity lovel 

R)nk cotton 

H-go scll moisturo 

High fortlhty lovel 

A-lnk OO1ton 

Hot, dry, abo". 

Cnot above OO·F 

Rttnk collon 

113 

113 

213 

1113 

1 113 

PFtEP'fl.! 

RATE 

t.. 

2,0 

0,25 

0.25 

0,5 

1,0 

1 ,0 

6 

4 

3 

24 

\2 

6 

6 

SPRAY VOLUME 

(OalalA) 

15·50 2 ·5 

15· SO 5010 

10·50 

2·5 

APPLICATION 

TIMING 

Apply 4 \0 7 day. pr!::H 

defoliant. Enhanoo. 

crop dololla.\ion rtduoin.1 

dOlorlorallon of boltOm 

and allowt for ;;"ril'~rl 

·pratr.atm.nt Wllh Oolollonl. P,lor 10 PREP'" Sol! Oponlog Tr •• lm.ol 

If Ihe colton Is overly fanl; or \Ilylng down In the mlddln and good spray covoreg. of the bol$ with PREpn.! 1$ dllficuil. a prG1fOalmenl 

w~h dofo~anl$ Vim be useful to lmprove boll coveragu with PAEpi'M, Use do-saoo rtl!&' 01 PAEPN brand Ethephon Corton Bon Openor 

rocommondoo for bon OpE nlng. Read and obsGrve all approprlala label USQ c;reClions and procaU1ions for Iho doroliant us.ed. 

"In Cagiornla and Arizona use It velumi of no Ius Ihan 5 Oa!!ons por acre fer asr:e! app~ca'ion$c. 

Bolt Maturity 

...... bon Is mature whOrl fIls 100 hard to bl1l dented \vhClO oo.' .. G-azold b"lwae:'l Ih:;mb end lioQors: 100 hard to M slicod with a 'ha:p knffJt, .nd 

won the Had coal b&co"os Ughl brown In color. 

Use LImitations 

Do not oxoood a maximum of 2.0 lb. aliA lor comblnltd IJSGS 01 PREPTM por acr& per yoar. 

eoll Opening: Do not tank mix PRE?n.< brand Elhephon with« du!ccanllf lh9 cotton Is to be spindl-e harvustad. 

Pre-Condilion for Oefollalkln: 00 nol tank mix PREP"« wah dulocnnts unless p~ant dGslccallon is roqulred. Do nol use II de ollan! 

bGlore thore Is sufHcioll1 malure liilcpened bo:ls 10 produco Ihe dea!rod ylfJld ($80 Gonoralln!ormation 50clion on how 10 'Ol\t for bon 

maturlly, 

WHEN TO HARVEST OOTTON 

Dc: nol nauv"sl cotton ,ooner Ihan 7 days: after a treatmo"l, w!lh PREp7M brand Elhophon Cotton 80H Opener. 

Observe Ihe treatad crop nod haNasl when optimum boli opening has bMn leached, Too oarly harvo,1 mrghl reduce Ihe lull advanla99 

of Ihe Iraatmenl and 100 f,le 11 harv.n·1 may resull in rOdt.cGd" qua:;ty ard foss oj Hnt which wll! drop flom tho plant 
.... , ~,=,,','IY,,-,------------"--" 

............ --· .. ----.. ----------~T"CI'BeMArrC~C~O~------...... ----------.... ------

FREprw: 

Crop S1tuatlon PhllsfAcrl) 

Directed Spray 

Application 

aver-Tho-Top 

Application 

j 113 

I 113 - 2 213 

USE LIMITATIONS 

50·60 

40-60 

(Flue-Cured Only} 

Uso orop noulas. 

gpa a\ 35·40 

2 nonlos pOr 

tho spray to 

I 

Specific Dlrectlooe 

00 spray lips dosJgnod 10 apply ! 

tractor speed of 2·3 mph. 

sId, of the row dropped low enough 10 

rIpened and harvul.d. Thorough .pray .. dlraettd spray. b, CUfe 10 harvG$\ all inavG$ 

Traal only when loaves fomaJnlng on Iho stalk are- maturo, To Ol1sur. 

remaining Joan. are maH.ne. tosl spray sovora! tobacco plam& as 

d8$C;I1»d undor the netlon ·Prop., limo 01 iroatmant." UiIII the lOwer rato 

In a normally mature crop whon exporl.nco rndk:alos Ihat mInimum rip4ning 

lnduooment r. rGqulrad. U .. tho higher rale who" tho crop Is hoavy aM 

a lende"cy 10 be mort rank or wh." t.mperaluroa art Iowor than normal. 

Always 10$1 spray 10 datormln. 11 Iho tobacco 1; maluro onough to respond 

10 Irealmenl wilh PREpnt brand Elhephor.. 

Apply oyor·lho·lop PReJ'"fH bral'ld Ethophon spray as a {L"IO miSI uSing 

nozzles nozzl. tips ovor Iho conlor of tho plant, and each 

so all are covered similar 10 the 

00 "o1 apply PREprn brand Elhl}phon to im('rltl;\irQc leaves il$thls can r$$ua Itt unsallstaclory coloring, ..... QIghl iO$$ and reduced leal 

quality. 

00 nol albw Ihfi crop \e ovor ryan :n the tlc:d n!ler using PREpt>1 brand EthQp-hOn, 4!nCG Ihls. may cause ,omo roduclion In ylold ana 

Qualily, 

Do nollreat bofo(e Ilntl:ipal&d ma;or slorm which could piCt'lenl hat"tSI and nu,ul11n crop 1:)$$, 

Do nol apply PREpn.! b'and Elhephcn If raIn 1S oxp&CtG-d WIthin 4 hours, 

APPLICATION TIMING 

Succoulul rotults. with P=tEp'l"V cal! fQr Irulmanl when l&avGS afe mat"rq, nol oVlO'rly rank gr90!'\ wha(\ sprayed, To eas:\y ctl'lHmlm, 

tho propor tr&alnWn\ t1m:rg and tho "umbor 01 I{HlV6S po: sla!k r"tldy for hafV(J$~. t2S1 spray $&V$ra! p:anls in mote Inan onG loca'il}!l il1 

oaeh field and ob$ervtlhn response. Matura l.-avos wlli Mgln to yoHow in 2410 72 hours. Te$IIQavolllhal taU 10 ,allow 1072 hOlifS aro 

flot mature and are nol mad, for PREpm brand Etnophon troatment. Wah a fow days. 10 pormll furlh;)r nalora! malUring, tlien make 

anolher tO$l spray or ~maIUfIIY' chock. 

When you havo conllfmo!llhe n!lmOOf of !oavos oor planllhat Wlil coior, you cao d$lerm::'\0 Iho nllmber 01 acros to lroal in Older 10 f!ll 

4vbarn ... 

pan yO:"r t9.sl spr.y b, mIXIng one leaspoons of PREpn!: In 1 q~art or wal;)r. Spray each I&st planl With aboul t oz. of this m'>::turo, 

va ring allla'V"s with a 'ine mitt PREpw brand Ethophon will nol color imma:uro sprayad luvlJos. 

WHEN TO HARVEST 

All mal%, sprayed /GaVel! VI~I oogin to color within 2410 72 hours allor PREpm brand Elhophon appilcsl\oft. The yoJ:OWII1Q ptocus is 

weather dopendanl; cool weather wlU dalal', wh:!a hOI, slinny w&a~h.r can eporrj \ip th. p!'OCiISS, Harvut traaled tobacco when haves 

have roaoh,d the do.lred color lnluns1ty. 

Do nol allow tobacco 10 b-lcomo CVGr rips oetoro slarling haNGS\' Lnf drop can occur who" tobacco Is over ripe and lalt on Iho stalk. 

If II numbor of tho boltom loavn have y&!lowod a! Iho 11m. 01 traalrr.oni, :bill' shOJld b$ htl.(vasled prior to spraying w!th PREpm brand 

Elhophon. 

Wllh an over·lho·top appliC8tion, narvGstlng can oommoi'lCo 24 houri. after PAEpN brand Elhephon app:lcallOn d&panding on wNtther 

cond,\ton$ or to avoid ova. ripe lobacco. Tobacco harveSt6:! 24 howrs IIJ:er Ireatrr:ont will require mora limgln IhQ colorIng phase of Iho 

curl"O procoOI. 

CURING PREP"' TRE~TED TOBACCO 

CorinC procedures .ro as mvch an art as II sc:anca ancl each CJ'/} n~u~: bo jJdg&d 0;) Ih!) basis 01 :obaoco condiliofl, Inlerval b01Wten 

IrealmfJf\l and harve'l, wnlhu( am;! typo of eUl,og facility batOrt prosClipHon lempOra!uro and ltonUiatlon schedulos Ci'/fl bg 

G$tab'lshed. 1'0 ob1aln mlxlmum c,.uaMy, c&.tO musl bs tak&1'l \0 obt.GNa and oonlrol Iho cudn-g Pl0COS$ clOS$1y, (lspeolany dtJtlrg Ifle 

lato ·colorlno" and early ·crying'" slag&o or Iho loa!, 

F'A.EPN brand Ethephon trealed tobacco wLl ha .... el!ilartl;ld Iho colOring prOCQSS wf1&n harYo$led, rO'duo:ng Iho timo requirod In ths 

coloring phato 0{ cwll'lg. rreated tobacco should ha drlad IMtor. !f tobaooo tnyu ar. gre." OfO?nlail'l lome grGon when hlltll.V, .. d. 

It may b. necsssaty 10 ool::n Ihom for a faw hoUfS, Illha tOlvlIIS are oomp!ol.oly yoV-ow, IOfl\jXlratvTo and vantllalion musf b. adjuslad in 

a mannor 10 dry tho lobac«:l !islasl U f»$$lblo v;iln-:l'ul :tea!dlng, One&" ~ho Ibaf It dried (3/4 dry}, you .hooklloUcw normal proo.our •• 

for C\t(mg. Slt\OG: PREPfM brand Elhapnon Ir&aloO !&a"1)& curo 1il$I&r, 1roaled end unlroalod loavo$ shoutd nol bo curod logolher In tho 

aamobarn, 

132 
.' , 

LIMITED WARRANTY AND DISCLAIMER 

Tho rnanulaotwl}t watra 'Is \3.) that this product oontorms 10 tho ch~mlca! dei-CflpUon on tho- lilbGI; {b} thal this prodtJct Is rouollably lit 

lor tho P.Jrp<)UlS 401 forth in tho directions lor U$& when It III usod In accordance Wiih elJch direction.; and (e) thaI tho -dlr(!e{lona. 

warnlng and o:bot statemonts on Ihis lab!)! at. basad upon riuponslbfo exports' evaluation of rusonable tosls of of!octiYonoss, 01 

to:t:icity to labora:ory animals and to plants, and of rosiduu on food crops and upon reports olliold oxporlonct. Ta$ta hall. not boan 

made on al\ '1imMles or h all slatu or ur,dor all cond!\IOrIs, THE MANUFACTURER NEITHER MAKES NOR INTENDS, NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE, ANY OTHER WARRANTIES, EXPRESS OR IMPLleo, AND IT 

EXPRESSLY EXCLUDE:, AND DISCLA!MS ALL !MPUED WARRANTIES OF t~RCHANT·ABIUTY OR FITNESS FOR A PARTICUlAR 

PURPOSE. 

THIS WARRANTY OOE:, NOT EXTEND TO. AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR. ANY AND ALL LOSS OR 

DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENr WITH THE .. ABEL 

DIRECTIONS. WARNINGS OR CAUTiONS. 

BUYER'S EXCLUSIVE FIEMEDY ANO MANUFACTt!AER'S OR SELLER.'S EXCLUSIVE L1ASILITY FOR ANY AND ALL CLAIMS, 

LOSSES, DAMAGES, OF,INJUR'ES RESULTING FROM THE USE OR HANOLINGOF THIS PRODUCT, WHETHER OR NOT IlASED IN 

CONTRACT, NEGUGEN)E, STRICT UABIUTY IN TORT OR OTHERWISE SHALL BE LIMITED, AT THE MANUFACTURER'S OPTiON, 

TO REPLACeMENT OF. OR THE REPAYMENT OF THE PURCHASE PRice FOR. THE QUANTITY OF PRODUCT WITH RESPECT TO 

WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL. INDIRE')T OR 

"'...oNSEOUENTtAL c t, \!1GES RESULTING FROM THE USE OR HANDUNG OF THIS PAODUCT 

NonCE TO BUYER 

Purcha'1'. 01 thi$ pro&Jcl dotls 1'01 COllfGr Emy rig'll!> und'l! pa:icntll gov&rnir,g lh:s product or tho 1J5Q II1&r&o1 In CO,I/'l!t;ac ouald. 01 tho 

Ur,il&d Slalos 

_ F.F and Gulhkm BIO rD\I,t1(Hoj traOQm8lk$ 01 Bayor AG, Oormany, 

fCPP Is a r&gislored Ira(iemark 01 NOR·AM Cn&mlcal Company, 

!l.Harvad9 it a r.;;rstnrGd ti<ldomark 01 Un:royal Company, 

4Ma!alhion 110 6 Iradoma'x. o! MerICa:! Cylinamid Company, 

• 

Rh6ne,?oI.;IQn¢ AQ Company 

P,O. Box 12014, 2 T.W, Aloxandar DrivG 

Rosearch TdanG~. Park, N:lrth Caro:lna 27709 

PREP 15 InO :ra4omar'1\ 01 Hh6no·Poulonc lor EthGphon C:;r.C11 Boil Opor~r 

FOlEX is a rogistoroo Iradomark 01 Fl~Mo,Po\Jw.nc 

PREpl'>! brand Elhophon for Cotton an<:! Tobaoro (PENDlNO) Resuomltted 1217/92, 
------------'-'--- -

Mr. Warren A. Davis 

Rhone-poulenc Ag company 

P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle park, Ne 27709 

Dear Mr. Davis: 

Subject: Add Use on Tobacco 

PREP Ethephon cotton Boll opener 

EPA Registration No. 264-418 

Your Submission Dated october 26, 1992 

prior to approval of the new use, you must comply with Title 

40 Code of Federal Regulations Part 152 subpart E - Procedures to 

Ensure Protection of Data Submitter1s Rights by choosing either the 

Cite-Allor Selective Method of Support. Please note that under 

the Selective Method for this product, you must submit a Data 

Listing of all product specific and generic data required by 40 ern 

Part 158 since this product does not qualify for the formulator's 

exemption. For each data require~ent, you must submit or cite an 

appropriate study or document that a data gap exists. 

We have no adverse comment on alternate brand name and the 

revised labeling except the Environmental Hazards statement should 

be updated to inc tude the following statement: 

Do not apply directly to water, to areas where surface 

water is present or to intertidal areas below the mean 

high water mark. 

We are holding the labeling in our files for this product 

awaiting "resolution of the above issue. 

Sincerely yours, 

0v,"~ \J 

Cynthia Giles-Parker 

Product Manager (22) 

Fungicide-Herbicide Branch 

Registration Division (H7505C) 

134 
/' 

"'PR E pm BRAND ETHEPHON FOR COTTON AND TOBACCO 

For Commercial Use Or Agricultural Usa Only. Not For Residential Use 

ACTIVE INGREDIENT: Elhephon (2'(;hloroelhyl) phosphonic acid' """, .. " .. " .. """""""""""""""""" .. ,55.4% 

INERT INGREDIENTS: ............ , ...... ,." .............. "" ........ , ...... , ......... ,,, .. , .. , .. , " ... "" ................. , """""",,, .. .4 4.6 % 

-This product contains 6 pounds ethephon per gaJlon. 

EPA Reg. No. 264·418 EPA Est. No. 264.PA.Q1 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

PRECAUCION At USUARIO: SI usled no loG ingles. no use otto producto hasts quo 18 informacion en Ia Gliquota Ie haya sido olCplk:ado 

I' uses are 

U.S. ,188 and,-.:ii.4Ci,ih9: license is granted to use this product In countries other than tho Of for any 

• 

uso not contemplated by this I liability tOf patont inlrlngoment may rosult from use or sale of this product outside tho United 

Stales. 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EYES: Hold eyelids open and flush with a gentle stream 01 water lor alleast 15 minutes. Gol medical aHontion, preferably an 

ophthalmologist. 

IF ON SKIN: Immodiately wash skin with plenty of soap and water, Remove oontaminated clath'Lng and shoos. Wash cloth'Lng 

$Gparato'y before rOUM, 

IF SWALLOWED: 00 not induCe vomiting. Promptly drink a largo quantity of milk, egg whitGS, golatin solution or if those are nol 

available, drink large quantities. of wator, Avoid alcohol. Can a phys;ician immediately, ,/ 

IF INHALED: Remove victim to fresh air. H not breathing, give artificial respiration, Administer oxygon If nocossary. Gel me<iical 

aftention, 

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

• CORROSIVE. Causes file aod skin damage. May be fatal it absorbed through skin, Harmlul ij swallowed or inhalad. Avoid broathing 

spray mist. Do not get in eyes, on skin or on clothing, Woar luillongth trousers, long sleovod shirt, protoctivo glovos, and goggles or 

faco shield whon handling, Change to clean work dOlhes: daily. Wash thoroughly with soap and water altar handling and bGfOl'O oating, 

or smoking. Romovo aod wash cootaminatGd clothing bGloro rouso. Kaop away lrom domostic animals. 

NOTE TO PHYSICIAN 

There Is no $p(tcific antidote. Alilraatment should be based on obsorvGd signs and symptoms of distross in the patient. Overexposure 

to materials other than this product may have occurred. 

Victims of sovere overexposuro, by inhalation, should be kGpt under medical obsorvation lor up to 72 hours for delayed onset 01 

pulmonary edema. In a victim of over-oxposure by logGttion. C8ralul gastric lavage is required due to the possi4Jlity qI stomach or 

esophageal perforation. this material is an acid. but usa 01 alkaline subSfaocos to neulralize it is contraindicat!ft.···· 

•••• ENVIRONMENTAL HAZARDS • ••••• • ••••• 

De not apply diredly to water or wetlands (swamps, bogs, marshes, and potholes). Do not cootamw,ata 'lMter when Qiaposing of 

equipment washwaters. • • ••• 

• ••••• ••• Do not contaminate water us&d for irrigation or domostic pUI'JX)S8$< :: ••• 

USE PRECAUTIONS 

•• •••• •• 

••• •• •• • • 

Do not apply PREpm brand Ethophon Cotton Boll OponDr through any typo of irrigation systDm. ..: ••• 

Avoid spray drift to nearby crops as this prodOCl will cause modifications in plant growth, Plant injury or reducoJ"(i,~iII rosult 

• 

Do not plant another crop within 30 days after treatment. •• • •• • 

Mix only tho amount of spray you expect to use eacll day_ Do not allow mixod solution to stand overnight. ••• 

135 
.- DIRECTIONS FOR USE 

It ,. a violation 01 Fedor.' law to use this product In a mannor Inconal.tenl with Its labeling. 

R.ad entire labol before using thl. product. 

REENTRY STATEMENT 

Mixers. loedeNS and applicators must WON a fuU laco shiold. long trousers, long s\ooved shirt, glovGS and boots to avoid as much skin 

and eyo contact as possiblo. 

Do not enter tremed fields within 24 hours after applicaHon unless protoctivo clothing is worn. 

contamlnato water, food. or foed by storage or disposal. 

contain.,. is broken or contents have spilled. follow all precautions Indicated abow and clean up immediately. BGfO(G cleanIng up, 

on luU trouhrs, long sloovod shirt. pro1oc1ive gloves, and goggles or lace shield. Soak up spill with absorbent media such 

I'~!~!~;~ Ot other suitablo material and dispose of waste at an approved wasla disposal faclUty. 

DISPOSAL 

wastes are acutely hazardous. Improper disposal of excess peslicklo. spray mixture. or rlnsata is a violation of Fooarallaw. 

wast., cannot be disposed 01 by us. according to label instructions. COfIIact your State PasUcido or EnlJironmental Control 

I~~;~,~~,~"':~e Haurdous. Wasle representative at the neatost EPA Regional OIfico lor guidance. 

i~ DISPOSAL 

the empty containers. Then offor lor 01 in a sanitary 

GENERAL INFORMATION 

COTTON 

A folIar spray 01 PREPN brand Ethephon wid accelerate openIng 01 matute unopGnod corton bolls and onhance defoliation which cat! 

result In earlier hruveat with an meteasod tecoverable yield. PAEpfM btand Ethephon trealmont on cotton allows increaaed efficion<:y 

lrom a once-over harvest, ) 

TOBACCO (FLUE~CURED): A loliar spray 01 PREpm btand Ethephon ptomotes. early, unifotm "'yellowing" 01 matute tobacco, 

PAEPTN reducos curing time, allowing mote efflc:lont use 01 curing batn space, and increased control over haNGSt schedulos. 

SPRAY PREPARATION 

Add 112 to 3t4 of tho tequired amount of water to tho spray tank. Start agitation. Add tho required amount 01 PREPTM brand Ethophon, 

and thG temainlng amount of water. Prepare only as much spray solution as can be used 00 tho day of mixing, Do not allow spray 

sotu1ktn to stand overnight Do not spill the conoentral:od product on spray equipment, or MY airplane parts. 

mv SPUS SHOULD BE RINSED IMMEDfATELYWITH PLENTY OFWAl'ER 

Use 01 a nurso tank is highly tecommended fat avoiding possible spill$, 01 concentraled lormulation on spray equipment at any airplane 

• 

part,. 

COMPATIBILITY 

PREPTW brand Ethephon ia compatibto with DEF1, FOlEX-, DreW. Harvadr· Methyl Parathion, Guthion 1, and Malathion", and may be 

applied In sequence or as a tank mixtute (DO NOT TANK MIX WITH DESICCANTS F COTTON IS TO BE SPINDLE HARVESTED). In 

somo cases slight reduction in boll opening response haa bGon observed when tank mixes with dofoliants were used. 

Good agitetion In tho spray tank Is essential and a tank mixture should_not bo allowod to stand without agitalion lor more than 5to to 

minutes. Read and observe all apptOprmto labal use dirod:ions and pl"GCautions lor the defollents and insocticidos used. 

NOTE: UndGl certain conditions,tank mixturos 01 PAEpTII brand Ethophon with desiccants containilY,J sodium chlotate could 

result In the formation 01 hypochlorous acids which on heating will emit toxic ehlorido lumes. 

• • EQUIPMENT CLEANING : ••••• 

Because 01 the acidic nature 01 thIs product, prolonged oxposute to spray deposit will damage acrylic plastics, Cftr;fl.Lr\palnts, and 

motals. •••••• • ••••• 

Rinse thorougho/ with a detergent and water all oxposed &c1y1k: plastic-typo materials (e.9 .• aircraf(:wln(jsi!ields), ami painted surlacos 

within an hour after exposute to spray deposits. • • ••• 

•••••• ••• At the end of .ach day. rinse thorougho/ with a dotergont and water all the metal parts 01 tho airCl).ft 4nd thtl aslCCiatod spray 

equipment exposed to the spray deposits. •• •••• : 

••••• •• 

• • •• • ••••• · •• .. • •••• 

.. . . , . · .. 

136 
COTTON 

EXPECTED PREpni ,~~~ SPRA. Y VOLUME APPLICATION 

USE CONDITIONS RATE (Gata/A) TIMING 

'R_E_' .~ 

I LBS A.I. •• Air" 

PREpm Hot and dl)' 8O"F or 1113 1.0 6 Apply when th. number of 

Boll Opener- hlghor maluro unoponed bolls Is 

01)' and 75 to 8O~F 2 1.5 4 15·50 2-5 

suWel.nl 10 produce the 

desired crop. See below for 

Cool but above 65~F 2213 2.0 3 tast of boll maturity. 

Treatmont uniformly opens 

2213 2.0 3 boUs 710 14 day.s 08111&1'. 

PREp-rw + High ooil moisture 113 025 2. 15·50 5 r 10 Apply .4 10 7 daY$ ... ~,to 

FOLEX· PAEpnt boll High lertllity level appl~'on. To be us.d:" Detolla"1 Tank Rank colton Mix a sequential treatment with. 

not I~ -pl~of PREPnt boll 

PREplll. Dropp2 High soli moisture 113 0.25 2. 10 rSO 3 ·10 Apply 4. to 7 days PljO~"~ 

Defoliant Tank High lorti!ity 10Yoi PREpnI boll opening 

To be used as MIx Rank colton 

I ~Ol i~ pl; ;.~;~:,. w:i 

, 

Pr.·Condltloner Hot, dlY. 213 0.5 12 Apply 4 to 7 days prior to 

lor Oolollatlon Cool, above 65°F 1113 1.0 6 15·50 2-5 defoliant, ._~~~ I ~'~P_, I , Rank cotton 1113 1.0 6 I ~nd allow. of I':'O~.~I;: 

·Pretreatment With Defoliants Prior to PREpnt Boll Opening Treatment 

If tho cotton is overly rank or laying down in Ihe mlddlos and good spf'ay coverage. of the bolls with PREP"m Is difficult. a pretreatment 

with defoliants will be useful to itnprove boN coverage with PREP'fM. 'Use dosage rates of PREpTM brand Ethephon Cotton BoU Opener 

recommended lor boll opening. Road and observe aU appropriate labal use direction; and iXocautions for the defoliant used. 

""In California and Arizona use a volume of no less than 5 gallons per acre for aerial applications . 

• 

Boll Maturity .. 

A boll is mature when it is too hard to be Oentod when squeezed between thumb and fiogers, too hard to be sliced with a sharp knife. and 

when the seed coat bocomO$ Ilght brown in cobr. 

Use Limitations 

00 nOt oxcoed it maximum of 2.0 lb. -aliA for combined uses at PAEptii per acre per year. 

BoH Opening: Do not tank mix PREpnI! t)(and Ethepoon with a desiccant if tho cotton is to btl spindle harvestod. 

Pre-eondition for Oofoliation; 00 not tank mix PREpTW with desiccants unloss plant desiccation Is required. Do not use a defoliant 

before there is sufflclont mature unopened bolls to produce the desired yield (soo Genarallnformation section on how to tost for boD 

maturity. : ••• :. 

WHEN TO HARVEST COTTON 

00 nol harvest cotton sooner than 7 days aftor a tlOatment with PREpm brand Ethophon Cottoo 8Q{'~er, 

• •• 

• 

•••• 

• • •••• 

Observe the treated crop and harvest when optimum boll opening has been roached. Too .arty hli(VQl rtllght reduct! the full advantage 

of tne treatment and too late a harvost may result h reduced quality and bss of linl which will drop !rp1"l1flJl piant·. •• 

•• ••• • • •• 

••••• • • 

• • ••••• 

••• • • • •• 

• 

• •• •• • •••• 

•• • •• • • •• 

137 
PAEpnc 

Crop Situation PlntalAcr. 

Directed Spray 

Application 

Over-The-Top 

Applicalio n 

ItI3 

1113-2213 

USE LIMITATIONS 

50-60 

40-60 

TOBACCO 

(Flue-Cu red Only) 

Spoclflc Direction_ 

Us. drop nozzlos. Chooso TG or OC spray tips designed to apply 50 - 60 

35-40 psi and at 1ractor spoed of 2-3 mph. Use 

row; ana on each side of the row dropped low onough to direct 

the lHves to be rip4tned and harvostltd. Thorough spray 

essontial With a directed spray. be sure to harvest aU Ioav" 

Trea1 only whon loaves remaining on Ihe stalk are malure. To 

remaining leavos aro mature, tosl spray soveral lobacco planls 

ducribod undor Ihe s&ction '"Proper Time of Treatment· Use the Iowot 

in a normally malure crop when experience ind)catos thai minimum """'19 i~ment is required. Use the higher ra1e whon the crop is heavy and hu 

a lendency to be mote rank or when temperalurcts are Iow.r Ihan normal. 

Always 1051 spray to dolonnine if tho lobacco is maluro enough 10 respond 

10 troatment with PAEpN brand Elhephon. 

Appfy nozzles over-tha-top (one nonle PAEp1lA,~~~~~~:~!: tips 

so alt leaves aro co.\'.~'>d 

as a fine mist using Ihree 

, and each side) 

Iho I 01 

Do not apply PREpn. brand Elhaphon to immaturalaavos as Ihis can 18!mlt in unsatisfactory coJoring, weight loss and reduced luaf 

quality. 

Do not allow the crop to ovor ripen in Iho field afler using PRE?ni brand Ethophon, since this may cause some reduction In yktld and 

quality. 

00 not lreat boforo anticipatlKl major storm which could preWJnt harvest and rosult in crop loss. / 

00 not apply PREprw brand Ethophon if rain is OXpoc1od within 4 hours. ' 

APPLICA nON TIMING 

Suceessful rosults with PAEPl10l call lor treatment when leavas are mature, nol overly rank green when SPfayed. To e.sUy determine 

Iho proper lroalment tlmlng and tho numbor of leavos per stalk ready ,lor harvost. lest spray several plants in mare Ihan on. location in 

each rlOkI and ob$OlVGtho response. Matl.>l'eloavos will begin Io-yollow in 2410 72 hours.. Tesllo.aVfJs Ihat fai to yellow in 72 hours aro 

nol mature and are not ready lor PAEpm brand Elhophon troalmen\. Wait a tew days to permit turthel nalural maluring, thon mako 

another tost spray or '"maturity'" check. 

•

Whon you have confirmed the number of loaves per plant thai witl COlol, you can delormine Ihe number of acreS to Ireat in order 10 flit 

Iho bam. ' 

Propere your lesl spray by mixing one leaspoons of PREP'DI1n t quart of waler, Spray each lost plant with about t oz. 01 this mixture, 

covering aU leaves with a fino mist. PAE~ brand Ethephon will not color Immalure sprayed leavos. 

WHEN TO HAIIVEST . AU mahJre, sprayed loav .. wlH begin to cobr within 24 to 72 hours after PREP'"' brand Elhophon application. The yellowing process Is 

wealher depondenl; cool weathor will delay. while hoc, sunny weather can spood up the process. Harvest Ireated tobacco when leaves 

havo roached the desired color Inlenslty. 

00 not allow tobaoco to become over ripe boloro slarting harvos!. leaf drop can occur when tobacco is over ripaJ arntloh on the stalk. 

If a number of the bottom loaves have yellowed al the time 01 trealment, Ihey should be harvested prior 10 spraYli'l"Wiino PREP"" brand 

Ethephon. • ••• 

With an over-Ihe-top appIlcatlon. harvesting can commence 24 hours after PRE?ni brand Ethephop~tion tli9tQiJing on woalhar 

conditions or to avoid ovor ripo lobacco. Tobacco harvested 24 houm after lreatmenl will require mtlre UmSt In Ihe coprlng phase 01 tho 

cunng process. • • ••• 

CORING PREpn! TREATED TOBACCO •• : .. : : •••• 

Curing proc:odur .. are as much an art as a science and each cur. must be judgod on Ihe basis of ~ conQitian, lolerval betweon 

Jreatment and harvest, woather and type of curing lacUity before proscription temperature JpQ.'iOnliia1ion d\:IOIduJes can bo 

established. To obtain maximum quality, ca.ro must be taken to observo and oonlrollho curing Proctss ~ely, e!lQOCiaily during the 

lale ·coloting· and early '"drying- $tage. of Ihe loaf. •••• - ••• 

PAEpnt brand Ethophon treated tobGCCO wilt have started tho coloring process when harvostod, reducing Ihe liml.rlqtil1ed in tho 

coloring phase of ClIfing. Treated tobacx:o should be dried faslor. If tobacco loaves are gr .. n or contain somo gt,Mn whon halveslGd. 

it may be neoosaary to colof thom tor a fow hours. If Iho loaves are complelely yellow. tempora1ure and vontilatk¢! rfllIIfbe adjusted in 

a mannor 10 dry the tobacco as fast as possiblo without scalding, Once Iho loaf is driod (3/4 dry), you should follow norma! procodur85 

for curing. Since PREpn! brand Elhephon treated Ioavos curefaster,lroatGd and untreatod leaves shorJd nol be curod together In the 

samobam. 

138 
I 

•. ' LIMITED WARRANTY AND DISCLAIMER ~:h. manufactorer warranls (a) IhaNh!, product conforms to tho chemical descrlptlon on thGlabel; (b) that this product is r9a$Onably fit 

'for the purposes sot fonh In tho dirOCCions for US8 whon it is used in accordance with such directions; and (el Ihat the dirGCtions, 

waming and O1l1or $1.atomonts on this label are based upon responsible oxperts' evaluation of reasonable tests of offDCtiven&ss, of 

toxicity to laboratory animals and to plants, and of residues on food crops and upon reports of field exp4llienco. Tests havo not been 

made on aU varierie4 or in all state. or undor aI conditions. THE MANUFACTURER NEITHER MAKES NOR INTENDS. NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES. EXPRESS OR IMPLIED. AND IT 

EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANTlES OF MERCHANT·ABILITY OR FITNESS FOR A PARTCULAR 

PURPOSE. 

THIS WARRANTY DOES NOT EXTEND TO. AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOA. ANY AND AU lOSS OR 

DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE LABEL 

DIRECTIONS, WARNINGS OR CAUTIONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SEllER'S EXCLUSIVE LIABILITY FOR ANY AND All CLAIMS, 

LOSSES, DAMAGES, OR INJURIES RESUlTING FROM THE USE OR HANOLfNGOF THIS PROOLfCT, WHETHER ORNOT BASED IN 

CONTRACT. NEGLIGENCE, STRICT LfABlLITY IN TORTOROTHERWISE SHALL BE LIMITED. ATTHE MANUFAcruRER'S OPTION, 

TO REPlACEMENT OF. OR THE REPAYMENT OF THE PURCHASE PRICE FOR. TIlE OUANTlTY OF PROOUCTWITH RESPECT TO 

WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALl MANUFACTURER OR SEllER BE LIABLE FOR SPECIAL, INDIRECT OR 

CONSEOUENTlAL DAMAGES RESUlTING FROM THE USE OR HANDliNG OF THIS PRODUCT. 

NOTICE TO BUYER 

Purchase of this product doe!! oot confer any rights under patients governing this product or tho use Ihoroof In countrios outsido of th. 

United States. 

e 'DEF and Guthion aro registered trademarks of Bayer AG, Germany. 

lOropp is a rogistored tradornaik of NOA·AM Chemical Company. 

3HaIVado Is a registered tradomark 01 Uniroyal Company. 

• 

'Malalhion Is a trademark of American Cyanamid Company . 

RMno-Poulenc Ag Company 

P.O, Box 12014. 2 T.W. Alexander Drive 

Rea&aroh Triangle Pari<. North Carolina 2n09 

PAEP Is tho trademark of RMn&-PouJonc for Ethophon Cotton Boll ~nor 

fOLEX is a registered trademark of Rh6no·Poulonc . 

PAEpN brand Ethaphon for CoHoo and Tobacco (PENDING) Submfttod t0I23192. 

. .... " . " , " , 

•••••• , ,, , .. ••••• , , , , ••••• 

, , , •••••• 

, •••• , •••• , .. , " , , .. ••• • , , 

.. 

, , .. " , •••• 

.. , " , , .. 

139 
• (;It RHOfIJE-POULEflJC ,~ , # 

• 

RHONE·POULENC AG COMPANY 

Onobef 25, 190) 

U S EnvlfOfo!'(":n!.;t\ P:-,jt<:" ;tE,n p,';Ie'":r;:: 

or f ice of P,;s t!( ;(!~, Pr')(J{ ;:rn C'(XUITlem ()r0i~E'~,3l! :,) Desf.( 

P00n~ 26(1 ,':c.., .:::rys~,)l n~jl ,~~~'. 2 

1921 Jeff,,[ SDfl i),-.r,':":; Hl';i\"iN;lj 

A.rlington, \J\! glr.ia 22?0) 

Attentlon: Cynthla Glles-Parker 

PI oduct rc.anager (27.1 

FungicIde HerbKiof Gra::til 

R~gjstr0UQ!' Oi'/;s)')n (!ITj0':"lC) 

-,tie- apprc<li.iti: i !;,,'2:-./;n9 / )U; ,)(teJ)t':r.c;;- ",: tl I~~ I'Z:D,:'1 rJ<;tiO'd Octi)bf( 20 1992 The cr~angfS 

Le.< LCj.;- [(lVl;'!J;-·n',.:l)lZ!l H~'2~:r{j S;:!.:t~{):: o~ til(: 1 ';:b:::l ila'~'(· b(;'O'n rC,)(jc, "nd as f0(juested (we copies. 

'')( trlf r I(ia t ! :!l'0; i, 19 ; '! a;~(',::r,.JNJ : 0,' \/O'_x I ""c::;rc;-" 

Sincerely, 

• 'flarr£:'n p." D,Jvl~. 

Sen lOr Reiji<:,t! .)~ 10:: l'1;::ncl~;':1 

i'\:g(;/ ',J)'~ ? i i • . ~L~\;8L "" ;:,(, ·/oe 

iP;;s'_~r,':;rl TRA_'iCo\ C ".~Wi' :,) l. 2,':'_ ,-, 

:,j"~;):'\(! /ifJ 

il<lR',,qF)h'",( TLI.UtJ'JflBC'-l·ly;:!r,; .\i;:'-i,' -·1-,,'.(; /, '. ,'\' 

iNrrfiNN,VV •• DSF1l'UiQ!',Sf'(W'i~L < h~, ',I~e+H I't))-.' ;,j,_, ",_.+r.,:" 'el < ,,_ 

• • •••••• 

• 

• • •••••• 

• 

• 

•••••• 

• •• • • 

•••••• 

• .. ••• • •••• • •• ••••• •••• 

• • •••• 

• · ., .. . •••• 

.. . . , . · .. 

140 

• ••••• 

• .. • 

• ••••• • • •• •• 
., 

ETHEPHON COTTON BOll OPENER 

For Commercial Use Or Agricultural Use Only. Not For Residential Use 

ACTIVE INGREDIENT: Ethephon (2~Chloroethyl) phosphonic acid- .............................................. " ....... ,.55.4~/" 

INERT INGREDIENTS: .......................................................................................................................... .44.6% 

·This product contains 6 pounds elhephon per gallon, 

EPA Reg. No. 264·418 EPA Esi. No. 264·PA·01 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

PRECAUCION AL USUARIO: 51 usted no 100 Ingles, no use 0$1(1 produclo hasla que Ie Informacion on la otlquete Ie haye sido DxpUcado 

Tho Use 01 this product lor a varlGty 01 plant growth regulation USGS is covorod by United States and loreign patents including 

U.S. Patents 3,879.188 and 4,240.819. No license is granted to use this product in countrios other than tho United Stales or for any 

use not contemplated by this label. liability lor pattlnl infringement may rusutt from use or sale 01 this product oulside the United 

Statos. 

STATEMENT OF PRACTICAL TREATMENT a IN eVES: Hold eyelids open and flush with a gentle stream 01 water for at least 15 minutes. Get medical attention. preferably an 

ophthalmologist. 

IF ON SKIN: Immediately wash skin with plenty 01 soap and water. Remove contaminated clothing and shoes. Wash clothing 

separatoly bolore reuso. 

IF SWALLOWED: Do not Induco Vomiting. Promptly -drink a largo quantity 01 milk, egg whites, gelatin solution or if those are not 

avallab1o. drink largo quantities of water. Avoid alcohol. Cal! a physician immediately. 

IF INHALED: Remove victim to Iresh air. II not broathing, give artificial respiration. Administer oxygen if necessary. Get medical 

attention. 

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

CORROSIVE. Causes eye and skin damage. May bo latal if absorbed through skin. Harmlul if swallowed or inhaled. Avoid 

breathing spray mist Do not get'ln eyos, on sk'ln Of on clothing. Woar lull lenglh trousers, long slGOved shirl, protective gloves. and 

EgIO$ orfac. shield whon handling. Change to clean work clothes daily. Wash thoroughly with soap and water after handling and 

3toro eating, or smoking. Remove and wash contaminated clothing bolore reus •. Koop away Irom domestic animals. 

OTe TO PHYSICIAN 

Thera is no specific antidote. All trealment should be based on observed signs and symptoms 01 distress in tho Pillen!. Overexposure 

to materials other than this product may have occurred. : ••••• 

Victims of severo ovorexposure, by inhalation, should be kept under modical observation lor up to 72 hours wr d.layed oos·~·~ 

pulmonary edema. In a victim of overexposure by IngesHon, careful gastric lavage is required due to tho poslibMy 1:If sto~ach oJ 

esophageal perforation. This material is an acid, but usn 01 alkaline subslancGs 10 neutralizo it is contraindicated.. •• : •• : 

" , 

ENVIRONMENTAL HAZARDS ':' ":", 

Do not apply diractly to water, to areas where surfllC1l water is present or to inhn1idal areas bolow the mean h'lgh wtlMromark:bO·not 

contaminate water when disposing 01 equipment washwatefS. ..:. • 

Do not contaminate water usGd lor irrigation or domestic purposes. 

USE PRECAU110NS 

, " " , •••• 

Do not apply PREpm brand Ethophon Cotton Boll Opener through any typo of irrigation system. :.. •• , .. 

•••••• , , 

" 

•••••• , , •••• 

Avoid spray drift to nearby crops as this product will cause modilications in plant growth. Plant injury or roouced yields wi!! result. 

Do not plant aoothsr crop within 30 days altor treatment. 

Mix only the amount 01 spray you expoct to use each day. Do not allow mixod solution to stand overnight. 

HOT RE;vIEIlED 

In Ar:r;01~{lanC0 utth PR Notice 82-2, 

i? ') S('i) ,')':; i')'«cft Leoeling Dated ,£"' /;,,:,~ " 

/ 

141 
DIRECTIONS FOR USE 

It Is a violation of Fedoral law to use this product In a mannor Inconslstenf with Ita labeling. 

Road entire label bofor. using this product. 

REENTRY STATEMENT 

Mixers, loaders and applicators must wear a lull faco shield. long trousers, long sleovod shirt, glovo:!! and boots to avoid as much skin 

and oyo contact as possible. 

Do not enter freatod 1i4lds within 24 hours aher application unlos:!! protGCtive clothing Is worn. 

not confaminate walsr, food, or food by storage or disposal, 

container Is broken or contenls havo spilled, follow aU procuutions indicated above and clean up immediatoly. Before cloaning 

fuiliangth trousers, long sleeved shirt. protective glov05. and goggles or face shield. Soak up spm with absorbent modia 

sand, earth or other suitable material and dispose 01 waste at an approved waste disposal facility. 

I~:~~J~~I~:!, DISPOSAL I ~ wasles aro acutely hazardous. Impropor disposal 01 QX¢O$$ pesticide, spray mixture, or rinsate is a violation of Fodorall 

thole wasfes cannot be disposed 01 by use accordill9 to labol instructions, contact your Stato Posticide or Environmental Co"',,,11 

Waste reprosontative af tho noarest EPA Regional Qfljce for guidanco. 

Then oUor lor 

GENERAL INFORMATION 

, "' ."dd d;:p<"_~ <01 in a '"',' • ..,1 

A foUar spray of PREpN brand Ethephon Colton BoU Opener will accelerate opening of mature unopenC'fd colton bolls and enhance 

dofoHaUon which can rosult in oanior harvest wtlh an Increased recoverable ylold. PREPTlo!. brand Ethephon Collon Boll Opener 

treatment·allows iocroased offlcllitflC)' from a once.over harvest. Somo premature drop of small, Immature bolls may be associated with 

treatment. 00 not apply boloro sufficient, maluro, unoponod bolls have dcweloped to produce Ihe dosirod yiold 01 colton. 

A boll is mature whon It is 100 hard to be dented whon squ&ozed betwaon thumb and IlngofS, too hard to be sliced with a sharp knife, and 

whon the $Oed coat b«:om05 light brown in color. 

For best rosults, thorough and uniform spray coverage Is required. k is essential that fho bolls are contactGd by the spray to obtain 

optimum boll oponing. Ohsorve treated fields closely. HalVost at optimum boa oponing and dofollatlon, gonerally t4 to 2t days aftor 

troatment. Sustained cool mal her with avorago day and night temporatures of 6S"F or lowor aftor treatment with PREpnc brand 

Ethophon Cotton. BoU Opener will delay the boll opening rasponse. 

Do not apply PAEPTM brand Ethephon Cotton BoU Opener if rain is expected within 6 to B hours. Ramtall within 6 to 8 hours 01 

appUcation may roduce product performanco. 

Certified cotton soad growers should observe boU and $Ood maturity bolero troatment with PAEpn.o brand Ethaphon Cotton BoU Opener. 

Bolls not compfoleiy mature might opon with treatment of PREpn4 brand Elhepbon CoUon Boll Openor giving Iowor quality seed, 

apray deposits of PREpTW brand Ethephon Cotton BoU Opener, whon loll on aircraft acrylic plastic type windshields for longor than t 

~ur, may react with this mat.~al, forming an opaquo Iilm or spots on tho surface which cannot be romovod by washing wllh water or 

any other cleaner. Rinse windshields with wator Immedrately after each lankload of PREpn. brand Ethuphon Cotton SoU Opener has 

boen applied. Thoroughly rinso tho aircraft with clean watOf atter each day PREpnI brand Ethephon Cotton Boll C>P.onor js applied. 

PREpl10I brand Ethophon Cotton Boll Opener may also affect cortain painls, and if accidental doposlls on paintod ItfJ;ects· such lUI cars, 

trucks, agricultural oquipmont, otc. occurs, theso objOdS should be rinsod with water as soon as possibfo (wIth,," 1 ""ur) to J!14~ 

permanent staining of the painted surface. :..... • • 

SPRAY PREPARATION • ..: •• : 

•• Add 1/2 to 3/4 of the roquirod amount of wa1er to tho spray tank. Slart agitation. Add tho roquirod amount of PREP~;rand EtllIpbgn 

Cotlon BoU Openor, and tho remaining amount of water. Propare only as much spray solution as can be usoo on tho d'ay 01 mixWt; .oe 

nOl allow spray solution to stand overnight. Do not spill the COrlCGntratod product on spray equipment, or any airplantvntts. • /lJ4Y SPillS SHOULD BE RINSED IMMEDIATELY WITH PLENTY OF WATER. •••• • ••••• • • • Use of a nurso tank is highly rocommonded for avoiding possiblo spills 01 concontrated lormulation on spray oquiwnegt,or any airplMe 

parts. ..:... ..: •• : 

EQUIPMENT CLEANING ••• •••• 

•• • Bucauso 01 tho acidic nature of this product, prolonged exposure to spray deposit will dam ago acryfic plasticl, cd\faIn painls. and 

metals. 

Rin$O thoroughly with a detergent and wator aU exposed acrylic plastic-typo materials (e.g., aircraft windshiolds), lIlld painted surfaces 

within an hour aftor exposure to spray deposits. 

At the end of eech day, rlnso thoroughly with a dotergant and wator aU tho molal parts 01 tho aircrall and tho associated spray 

oquipmont exposod to tho spray deposits. 

142 
.... ~- .~~~~-~--~-

PRETREATMENT WITH DEFOLIANTS l"RIOR TO PREpN PLANT REGULATOR 

If tho cotton is ovorly rank or laying down in the middles and good spray ooYoraga of tho bolls with PREpn< is diffICUlt, II. protreatmont 

with dolollarns wU/ be useful to improve bolt CClV(f(aga wnh PAEpnt. Usa dosago raiM of PREprw Plant Regulator rocommooded lor bon 

opening. Road and obsorvo all appropriato labal use dir&elions and pr&eaU1ions for tho dofoliant used. 

00 not oxcood a maxImum 01 2.0 Ib ailA for tho combined use as a procondltloning treatmont for doloUruion and cotton boll opening. 

00 nol usa adGfoUant beforothoro uro sufficiont maturo ullOpGned boUs 10 produCG tho desired yiold (sa.Genoral fnlonnatlon s&ctlon 

on How to Toot for BoB Maturity). 

BOLL OPENING 

Spray Volume 

Rat. (Gala/A) 

Conditions expected 1 Gallon Application 5~7 days after treatment Plnt.fA LB' A.I. Treats Ground Air Timing 

Hot and dry 80" F or higher 1·113 1.0 6 Acres 15·50 2·5 Apply whon the number 

Dry and 75 to 80" F 2 1.5 4 Acros ot mature unopenod 

bolls is sulficiont to 

Cool but highar than 65" F 2-213 2.0 3 Acres produce the dosirod 

Rank collOn 2-213 2.0 3 Acres 25-50 5 yleld_ 

RESTRICTIONS: Boll Opening 

• tn Catijornia and Arizona uso a volumo ot no loss than 5 gallons per acre for aerial applications. 

FOR pr:r:OI 

Spray Votume 

Rate 

15-7 days aHer' DO. " las A.1. 

1 Gallon 

Air 

Hot and dry 800' F or higher 213 0.5 12 Acres 15-50 2·5 , A.P!'r.4 10 7 day~pr~r 

Cool but higher than 65" F t-ti3 1.0 6 Acres lan< m;, wl:~ ;:!~~ Rank ootton 1-113 1.0 e Acres 

(SGO I I 

'~ctlonl' "? ~t lank 

mIx wIth 

unloss I, 

RESTRtCTfONS: PrecondItioning for Defollatfon 

•

• In Catffornia and Arizona uso a volumo of no less than 5 gallons per aCte for aerial applicalions. 

00 not oxCG&Cl a maximum ot 2 Ib aitA for tho combinod use as a preconditioning tmatmont for defo~ation and cotton oon opening, 

• Do not use a defoliant bofore thore aro suffICient mature unopened bolls to produce tho d9Sirod yiold (50e Gonerallnformatlon), 

COMPATJBILITY : ••• :. 

PREpUI brand Ethophon Conon Bon Openor is compatible w~h DEFI. FOlEX*, DROPP2, HARVAOE3. METHYL PARAllUON. 

GUTHlONr AND MAlATHION", and may be appffod in sequenco or as a tank mixturo (DO NOT TANK MIX W~~tCC~TS II! 

COnON IS TO BE SPINDLE HARVESTED), In some casos slight reduction in boff opening response has heerrtobseNod wh.oIl.tiL'~ 

mixes with defoliants were usod. • •• 

•• 

Good agifallon in tho spray tank is Gssontial and a lank mixture should not be allowed to stand without agilation for .ogre than.5 $Q J 0 

minutes. Road and observe all appropriate label use diroctlons and proc3utions tor the defoliants and insecticidos usdd, •• : ••• 

PRECAUTION :... • •••• 

00 not tank mix PREP"' brand Ethephon Conan Boll Opener with dafollants containing IOlflum cftMr'la1' 

bocauS8 this resunS In Ihe formation of hypochlorous acids which Upon heating omit toxJc t;hlOilna fum •• ~· 

WHEN ••• •••••• TO HARVEST •••• •• 

00 not harvest cotton sooner than 7 days after a troatmenl with PREp-ni brand Ethophon Cotton Bon Opener. ••• •• • • . , . Observe the treated crop and harvest when optimum boll opening has boon reached, Too early harvest might rodlke lflft full advantage 

of the troalment and too late a haMs! may rGsult in rooucOO qualify and loss of lint which wlR drop lrom the plant. 

143 
LIMITED WARRANTY AND DISCLAIMER 

ThQ manufacturer warrants (a) Ihallhis product oonformslo the chemical doscription on the label; (b) that this product is reasonably fit 

for tho purposos sot forth in tho directions for use whon It is usad In accordance with such directions; and (c) that the directions, 

warning and other statements on this labol aro basQd upon rosponsible experts' evaluation of reasonable tests of effootivonoss, of 

toxicity to laboratory animals and to plants, and of res[du •• on food crops and upon reports of field exporience. Tests have not beDn 

made on all varieties or in all matos or under all conditions. THE MANUFACTURER NEITHER MAKES NOR INTENDS. NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES, EXPRESS OR IMPLIED, AND IT 

EXPRESSLVEXClUDES AND DISCLAIMS AlL IMPUED WARRANTIES OF MERCHANT-ABIUlY OR FITNESS FORA PARTICUlAR 

PURPOSE. 

THIS WARRANTY DOES NOT EXTEND TO, AND THE BUYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND ALL LOSS OR 

DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE LABEL 

DIRECTIONS, WARNINGS OR CAUTIONS, 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, 

LOSSES, DAMAGES, OR INJURIES RESULTING FROM THE USE OR HANDUNG OF THIS PRODUCT, WHETHER OR NOT BASED IN 

CONlRACT, NEGLIGENCE, SlRlCT LIABILfTY IN TORT OR OTHERWISE SHALL BE LIMITED, AT THE MANUFACTURER'S OPTION, 

TO REPLACEMENT OF, OR THE REPAYMENT OF THE PURCHASE PRICE FOR, THE QUANTITY OFPRODUCTWITH AESPECTTO 

WHICH DAMAGES ARE ClAIMED, IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL. INDIRECT OR 

CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDliNG OF THIS PRODUCT. 

NOnCE TO BUYER 

Purchase of thi$, product dOGS not conler any rights undor patients govoming this product or tho uso thereof in countries outsldo of the 

United States, 

The US& ot this product tor a variety 01 plant growth regulation uses is prot&CIed by various United States and foreign patents inClUding 

•

,S, Patents 3,879,188 and 4,240,8 f9. No license Is granted to use this product In countries other than the United StatGS or for any 

s9 not contomplatlld by this labol. liability for patent Inlrin9Omont may rosult trom use or sale of this product outsido tho Unked 

States. 

t DEF and Gulhion aro fOg/sterad tradomarks ot Bayor AG, Germany. 

2 Dropp is a registered tradomark of NOR-AM Chemical Company. 

3 HalVade is a registered trademark of Uniroyal Company, 

4 Malathion is a tradomark of American Cyanamid Company • 

• 

AhOne·Poufenc Ag Company 

P.O. Box 120t4, 2 T.W. Alexander Drive 

Research Triangle Park, North Carolina 2n09 

PREpnt is a trademark of RhOne-Poulene. 

Folex® is a registered trademark of RhOne·Poulenc . 

PREpnt: hraru:l Ethephon Cotton Boll Opener (MASTER) Approved t0120192. 

• • •••••• 

• 

• • 

•••••• 

• 

• 

... • 

• 

•••• • ••• • 

• .. • • • •••• 

.. • • • • • .. 

144 

•••••• 

• • • 

• • 

•••••• 

• • .. . ...... 

• • ••••• 

• 

• ••••• 

• .. • 

•••••• 

.. .. • • 
:.. , . . p",,,,, 1" •• ",'fi.M 

I~) e. U"'~=~p~= :r.;:05'8t'" Registration 10pP ''''"'''cr Nom"" ftEPA' - _ W""""ton, DC 204'" Amendment ~7 . Application for Pesticide: ~ Other 153345 

I'" Company/Praduct Number 

_AlA 

'2. EPA p,,,,,",, I'· c, G. Parker 

4, ComPMYif'«:Iducl {NllIM) PM. .--_ .. --._.- o None o Restri!;lmi 

'lenc Ag Co. .:2.!2--

5, Namo iIltJd Add/'&$$ of Applicant (fndvdo ZIP C<xJoJ fb}{i), my product is simlll;r or klenlica: i~:~~~l~n and 

2 T. W. Alexander Drive 

E 

10: 

P.O. Box 12014 

Research Triangle Park, NC EPA Reg. No. ~,.-

o Check if this ($ n new address Product Namo 

.1 I 

~ Amo!"ldment - Explain \)glow RMI pnnlad labels in rospontu to 

- ~y Ioltvr daltXl 

~ Rowbmiuion in rotponoo to Agency loner dalod 

-----~"" 

- 'M!) Too' Appllc411on. 

r- Nolillcatlon· Explnin below, OIticr - explain b&law, 

Usc additional pag&{s) 11 tWcouary, (FCiI" sC{;lioo I and Section IL) 

Add tobacco to the Prep 1 abel from Ethrel Plant Regulator label, EPA Reg. No. 264-267. 

Rates have been calculated to apply the same amount active I A as currently registered. 

Both labels will now have recorrunendations fo"r use on tobacco. Also. alternate brand 

name request as PREP brand Ethephon for cotton and tobacco. 

liU 

I" , ",",,,,,, Wlil Ue ""' ..- Yes 

IWaw, 12, ~ . 

BY'" .-- Yes: f-- ;;;:''''Iic - - No No No ',., ~: NO<,~r If''YC$,~ No"" • Certification mu.t be oonl!:uncr PIld<agowgt. COfltamer 

I ,3 . Not , S"* )'Oi, I 5. 1 "", .. 

0"",. n, B~t;b,;;"'" i ",rod",' 

G, "'"""in Ho P"",",' 1= 0""""[ , 

: .. ::. 

N,,,,,, fliC 

Registration Manager ~ ,No 11001"''' 

Warren A. Davis Senior • 

: -=- '~.' 

I certify that the statements I h31fQ made on Ihfs form and 1111 attachmontt ihl)(&iO rue two, acwrato and compIo~": •• I·~"OO 

! IIckoowlcdge- thaI any knowingly la/$(! or mlslcadifig &lal$(f\oot may ba punishable by fino or imprisonment Ct.: •• 

oolh under app~oabl& l::tw : .:::~ 

1')# CUtc~ it 13, ntl. •• • •• • 

Senior Registration Manager • •• 

I" ",..Nam, j5 Dato 

Warren A. Davi 5 October 26, 1992 

145 

EPA " _EPA ~ Y,I[ow· oopy 
---------.~--

• . L:' 

PAPERWORK REDUCTION ACT -"1I0'l'!l:!E and INS~UCTJ:ONS 

PAEERWOru:; R:iSDUCTION AC'"£ HOTIgJ,: Public npcrtil19 buriWr'! fer tIllS i':1'lllecHen (If'1r1fcrMti~ lh"j 

eU1IMteci to lWer~ 0.85 hour per f'1l~~ lne{Vdlny til$S fer rwJwlfIU iNtr\iCticrra, $€l'nrehing exillting"data sOW''t¢!., 

9Mhiirirm awJ maintainlng the daw nemlecl; and t~{trt:lX~:',0nd " ',th~ CQll«:tlon of informatioo, send coollWnta 

regarding the burMn Oil,llMt", or IIrtl' other J'l6p%tt'Of Hilfr Ntl JtJ1crootien, including lH,lggentiCl'4 for recludng this 

b.ird«l, t<') Chief, InforMtltl¢l'i Potiey srarn:h, HF2D, us, 'tmi ,':'~h:!tectioo Ag!ltlCy, 401 M tit!'"t, SU, Viltrldnsten, be 

20460; ard to- the Office of Infornaticn l>rn1 Rli$t!letory AHeirs, leli 6f H"na1;mMnt tlnd Budget, lJushington, DC lOS{)3. 

INSTBUC'TIQN§: Thls form i& to 00 Ut~ f<;w alt appUcr.tiwm Tor fh'U regl§tf<l!tioo, end ose reregistration, &liIYldmnt, 

r~ubmfllsion, to applicatIons for ~tifitatiOh$. fih4i printed labeling, r~registratlon, etc. In ortlct to process an 

~ppticntlon for a new registration submitted on this Torm, the foll~lrt9 material ~~$t accompany the application; 

1. Certifictltion \{ith Roop«t to CltatHm 01 /{,ijta {ErA fem M?iF29}. crf rwt ~>:oo,..ned by 40 efP: 152,t1 {o} (4)1; 

2. Confidential StatefOOnt of fO!"1all./l (nM FiWm 11570'4): 

3. fOrNlat(fr's EXlWptlon Stlltetmnt O,p" ftrtm a!!'11:H~7); 

4. flv« CopiM of draft {.meling; 

S. Thr@e copies of nny ddta submftted; 

6. AlJthorh:lItfM tetter uflcre appl icr.ble; 

7. Hatrh::u; .mere applicable. 

SuI::<i1ill&i¢l"j of labeling - labelIng should first be s5.Jhm\tte<:l in the form of draft tabels with lilt applications for rMii 

reglstr4tion. SUCh draft llJb,2ls may be in the fONl! of typ«.l lOOcl text co 8.5 x 11 irn:h ~r or a If<<kup Qf the proposed 

l.l. if prepar¢d /Hi 3l11OCi:up, it should be corn:;:tNCtro In such It fiay as to facilitate storage in an 8.5 x 11 Inch fit*. 

Mockup tabels signlflCat1tly -.lttar than 8.5 It 11 inchn should be II\Q(Z'1tOO on 8.5 x 11 inch IXlpEf far su!;.:milwiMl. 

stJ:af/udon of Oatil ~ Data l;-utmj!~ed in t\JPPOrt of thit application must 00 suJ..:rl1itted in accordance with Pit Notice 86·5. 

§PECIFIC INSTRQCTIQN$t rleMe read th~ im:tructiom listoo bnlOloi bcf()rc c<'lll'9ll.!ting this ilppllcatlon. first 

determfrm the typa of regIstration action, listed in Glock A, for whith you are su/:nittlng this bpplication. fer • 

appliclltiern; sub!littlXl in conrwcticn >lith "<!II< R0QistrMf;:m aetiW'l$, Scctlom I, Ill, and IV lru$t ~ coapteted by the 

applicant. For applkatiotm subultted in COfif'lW.:tlon with ~ rC!listrllticn actions, rC(l:tkmitsions, rrotlficatiom, 

rercgist!'"aticns, etc., Scetlons I, fl, and IV IW$t be c~leted by the applicant. 

8lock A - Cheek the appropril'lte actiO!'! for which yOtl art! submit,ting thill fom. 

SECTION I'- Tllfs lIect!on IllJSt be coopteted, as ppplicable., for all registration m:ticn~. 

1.. ~/Pr«lJc:t Murlber - IMert your C~~, if O!'\C has be«\. ll$Sigl'lW by EPA. Thin- ~r MY have lAY! lIsllign,ed 

to yeu tiS n I»sic re:gilltrant, ill di!l,tributor, or 3ll ij.O e.!itnblrsh~t. If ytx.lr product b rllilhtered. Insert the P~t 

2. -. EPA Pl"Cd:Jct Kaoager - If knO\oil'l, f it I' In th!! nUM and PH r.urber of the EPA Proouct Htmager. 

3. propoilCd ClDS&iHcatioo • Specify the propYSed cl.uuificIHim: of this product. 

Ii. Product 118IIIIIt - Enter the c<:.$pletll' pro¢.lCt mme of this pollticiM IIII' It will apj')¢lIr on the llibel. thll' noom I!lU$.t t» 

specific to this product only. Duplication <)f rumQ is not permitted M!1iI'l9 produets of the $1lI!\e c~. 00 IWt ff';Cl:uOO 

any brand MIlle or ccapnny line oosigf)l\ltjoo£.. 

S. w~ M'Id Mdrus of Applicant - The rnme (If the fim or porsGflllnd nddre'M shown in yoor applic.a.,tlOf1 is- the penoo fH' firm 

to i1han the reglstratioo IOllt be iss\J1Ul. If you lire acting in bUlatf of another party, you !lM>t,submit ootherlzatlon fr01!l 

tlUli\ party to net for them In rQ9i$tratioo fflIjtteni;. An appl icnnt flOt rosiding in the United Statu must haw .en 

mltnodud agent residing In the Ul1fted States to act for them ill al! registratlOfllmltters. rhe twIie lind tOO'piete rmllina 

address of such at'l agent lrutt aGc~ this appt iClltl(m. 

6. Expedited Rev-iei - filM section 3 (c) 3 (8) previeWs fer exp«ilted rflvle1l of nppt ieadoo; for r¢ji!Hration, or ~t. 

to existing registrations, that nre similar or id¢ntlcal to O!hllr ~!l.tjdde products thnt are C1JrfClldy r'J-gfstercd wi!!'! 

the EPA. In order for your "pplication to be eligibte for ,wpedlted review, you MAt provltk'us with the'EVA'Regil>tt4tion 

Ntrrber liM prodJet ~ of the prodl.lct you bell¢Y<!' i~ ,limil"r to {)!'" idtotfcill! to your product. the product 1N$t be 

1I1mHar or identIcat fn both fOllallation mrl labeled l.<g'Hl. 

SECTION II ~ Thht section I!1.Ut be cOllflteted tor alt appticatioo; §.~itud ttl 1lfflffid the reoJistration .OfIly of a 

currently register(/d prodtict {koon:iY>tnt}, for a rem.lI:rnissioo in resporulc to at'! .Agency Icnllr, fer notiHcntfom; to the 

Aj)«li:'Y, ior 1he ~lllsion of final printed label ing, for reregiuratlrn and for arty othtr <lctioo th!!t pertlli'rw to II ~if 

ru·r99istst'Jt~. Thfs z"lCtion is.ill!! 1Q kg 0000 fcr u MY appticutb:/(1 for regilltrat!oo. 

1. Swject of $lbiIhwion ~ Check the I:If9ticlible block &ld provide the Agoney Ictter date if appl"t'lprlate. provide 0: briel: 

explanat.i&;~'.the purp«le(s.) for the submissjon. such lIS "the A&Jltioo of a alte, pest or crop (ap<l'cifY)"i l1am;;nd thl 

Confident'Ir'tat_~t":""I~:lFll'Ula by ..... ; "rercglstratico Sutmil!l;:ion"; 9~rlll lobel rfNiriioo of use dlret:ticns." Attach 

a scparatcotpaae if afdi"tiOlJ't s!»,ce is r;(lelkd. 

• •• 

SECTrml.tIt (P$lcS;aging and container Information) - ThIs SectiOn lWSt be c~leted for 1111 

applicatlorf ~tted i"'C\'l!'IIWCtlon IIfth new registration or appllcabte am~r;ts. 

1. Type ofz..t:taQing - CJwcl;; .. the awroprinte bled. if your prodt.let wfll be pilcbgoo in the indlcatoo Pilco::aging type5. 

lrdicate t~ stu of:th~lndividuat packets and ~r Pfir retail ccotaiMr. 

2. Type of Rftait.tootaf~'''rrdielllte type of container in Iffiieh product wilt be marketed. 

3. LocatiortS't~ Content$ - Spedfy the IWt contents of lilt retail cOt'ltainerll for your product. 

4. siu(s) 01 ie'tall COntainer - Speclfy !he rmt t:ententll of ill r~tilfl cor;tahwrs. for yoor prcduet. 

S. LocDtion.tf.l1cl Oit'eetions H Indicate the l«lItion of the !.me dir«:tit:.lrW for yoor product. 

6. Ibrner irrllhidl. labet is affixed to pNXluc't - lrdicllte the method prc.rciut:t labet 'it, IItta<.:hl}d to ruaH coouiner, 

SECTION IV (Contact Point) - This Stx::t1on Il'USt be c«l\Pletod for all 

I ••• , new products reglstratioo, rMIub;\hsien. "1!Itt·too,~ nr&gi5trlltioo, etc. 

loS. setf~exptanatory. 

6. EPA UM only. '146 
:~;,,~(~:, '~ . ~ ----~ ------ --.--- --.~--JfP'O--- "o/~- -~--~ --- ~-,,--- ~' -,-, '~ ~ 

, , , . , , " 

, 

, ,.!?"''44'/ • 

~~'"" , , on "' , 

.~& PA 0""" ,~. ~ 

lopp 1000,"" """b,,, 

t Applicatron for Other 153345 

A~'" 12 c j~~J:' _____ 

, o "mw O~cstrictod I', ak 1\ 

IPM. e 

flo ;,' ;;1,' - i5. NamaandAddro'$ 

" 

c_, 6, Expedited Review. In ' 1 FIFRA Section 3(c)(3) 

2 T A1e~-~ncler '''f)r-i 'Ie: 

(b)(i). my product is similar or idenlical in composition and laboUng 

, 

I • \{. I 10: 

r~O~ Box 12014 \--

!{C'sean:h TriStligle P.;tk1 '" EPA Reg. No. ,'l,~ o ' . Chcckjf,lhl& is a nowarhro'l!i Product Nruoo 

III , 

~ 

- Final 

, E,._'" bek<w 

- Ag""" j Rt:wbml$$ioo in roSpotlSO to Agl'mey killCr dated 

- "Me Too' Applicdlion. 

r-- :_ . -Explaln balow. Other - oxp!aln below. 

Uso additional pagels) iI,rcoo"ary. {For section land SocOOrt It) 

Add i., • _ to the Ptep 1&001 f~~,):nhn;l Pl\\flt Regulil.tor hbCl 1 EPA Re:'~h No~ 264-267 ~ 

Rat~s have been c111cu1ilt-ed tp\u, .. thG '5m~c ,>1wlJunt acti!e I A as currently registered. 

Botn' labels will now ~ilve - ons TOr use on tobacco" i\ bOt a 1tBrnate brand I 

~nmc- requEst as Pf£[P 

D ""' .. t,::' for cotton Jnd tobacco: , , f 

" , ;mI" !lnl . 

, , '''1 , J, , ' 1 wa", ' ' I~ ~Ol 

.- ,-. B-~·$~---- I Yes Ve' • - , .' r-I~~ • - r. noJi :- I=- .. , f', , , No"~ -.-~- , ", No " . 

i'jNopa, 'c , '. , If "'fUll,; No, per 

r. CMtiflMtloiJ must be IoVgt CQI'llainor PACkagc-W9l- eontainCf 

- . 3_ ' Net Contents I', Stte{.) • 

nl";" ' 0, ag::C;'; , , , 

1 

, ""_'0 _labell, "",~n '0 P""",," 

~~ DomorL..... _,-..l 

• • 

I';.,"'" 

iSt\'Btion Hnna9al'~-C""") n .. ' 

Harren , D-Jvh, SCil'lof' '" 

•• 16 :='~"'<lioo I certify \hilt tho sl8temtlnb I have mado on this form 

I &eknowlodQa thaI any knowingly 10100 ," mAY bo punistmble by '0 ••• (Stlftnpod) 

both under appliQllibie law t .... 

l>i~/(* ;/;/2 ~ .. :3. TIlle •••• 

t- - Sent~r FU:ij'l:str<1z'ion • • • .. 1 " 5. OnT<> 

&ig(n:!t " hI, tH -; i '", o!i.. t,;i !Jr J , 147 

<"A' Wh"", EPA V,Ik<w ' 
. • 

• 

• 

PAPERWORK REDUCTION ACT :" NOTICE " and INSTRUCTIONS • 

PAPERWORK REDUCTION ACT NOTICE: Public repcirtfJ'li burdm for this co!l&Cticn (ff InforrMtion I' 

Ktil!l4ted to average 0.85 hour per nspmse, InclUding tIme for rIWitwhtg lfUtruetiooo, t'li:lrchiTl9 existing data llOl.lf'CtHl, 

gatlwFlnu ;md maintaining the dnts ~. end c~;t!ting ~ rlW'i(tU;ng the I;oliccticn of ;rlioNMItien. Send c~nts 

regtlrdlng tile burden ost;mau or any other IHiput of tId; collection ¢f information, including :I<\Ji1gellt!um for reducing thi\; 

burden, to Chief, Infor~tion Policy arn~h, rn-223, u.s. Environmental Protection A!i~. 401 M Street, SU, US3hington, DC 

20460; ttnd to the Offic<.< of Informtlthm tmd Regulatory Affalrs, Offlc~ of lfunagetM-nt Wid Sudgtt, Washington, OC 20503. 

INSTRUCTIONS: T!;;:; form is to be used for all IIpplicat;Ofl& for MY r~itt:ration, end UM rcrCilistrlitloo, tmaflf.beot, 

ruutmlsslon, to applfcotiOflll for rKltifications, fir,j! printtd llll.mllng, reregfstfliltion, etc. In order to proceu an 

l'lwlicatfon for a MI4 registration $ubmitt«l on thIS forM, the- followlno mat.:>ri&l I!Vtit accanpany the application: 

1. Certificat;()(I with ReSlwet to Citation of Datu (EPA form 8570·29). [1f not eX"ptw by 40 CFR 152.81 (b) (4)l, 

2. Confidential St&t01MOt of fOnlllJla (I:PA form 8570·/j); 

3. FOrnllotor'. EXOO!ptioo Statemwt (EPA forn 8570-21); 

4. five coplell- of draft la~I lno; 

5. Tllree copies of 1m'{ data sultted; 

6. Authorlutlon letter where ewllcflbiej 

7. Matrices ~ere ~licoble. 

StlbIII5Slon of Labeling· L4beling should first 00 !!UI::«iltted in tile fONII of draft labels with all applicatlOO$ for new 

registration. SUCh dreft l&bels may 00 In the form of typed label text on 8.5 x 1l indl papor or a mod:.up of the proposed 

l~l. If prepared as a mockup, it should be constructed in Guch • way as to facilitate storag~ In un 8.5 x II Inch file. 

Mockup labels s.l9tlificantly 5IMller thno 8.5 x 11 irw:ne$ shoold 00 moooted on 8.5 x 1l im:h paper for subniGSiOl'1. 

Stbafssfon of Data - Datil sub'!!;tted In stlpp¢rt of thi!i application ItJJSt be subnitted in M:corclarn;e with PIt Notice 86-5. 

• 

SPECUIC INSTRUCTIONS: Please reM! thO) instructions listoo below Ix!fore coopletlno this applictltion. first 

detel1!lim the type of registration action, lisud In Block A, for which you are subnitting this application. for • 

npplications subnittEd in cOflMCtion with New Registration III!tlOlW, SectiOf'\$ I, IH, and fV M.l$t I» cC(lljlleted by the 

applicent. For opplicatlOO$ su!:mittw in cOf'li"lt:ctioo with BfOOI'ldtld registration act;OO$, resubmluioos. notifications, 

reregistratlOflS, etc., Sectloro f, If, ao:I IV mJSt I» conpleted by the applicant. 

Dlode A - (;h4C[( the flppropriate action for which you are sul:;mlttfng: this form •• 

SECTIQN I - ThhJ section nmt be c(lll'pletEd. liS applicable, for aU roti:>tratfon actiOfl$. 

1. CaIpany/Procb:t 1M'ber' IMert yoor CcRpany MUIibcr, if one hl)$ b«o 4nfSMd by EPA. This f'lI.ZIlber JIISoy hllw beenJIJ>slgned 

, to you a£ a basic regtstrMlt, to distriwtor, or.$ 30 utabillihMnt. If your product Ii> registered, 'intert the ProdJet -. . 2. iPJ. Pror.b::t Monoter - If known, fill In the nllllllf and 1'K l"IUtbor of the EPiProduct Manager. 

3. Proposed Clan-ification - SpttHy the proposeJ clnsi>fflclltl,on of tltis product. 

4. Pn!du.;t .... - Enter thl!" complete pr~t rn!i!Ie of this pestioslde as it wHl AfJPIlar on th/f lebel. lhe nMIt !!'Ost be * 

specific to this product Of!ly. Dupllcatlon of names h Mt permitted among pl'oCuct& of tile s~ c~. iooot include 

afr( brand /'IaI'MI or c~ 11M ck$!gMtloru;. .'-" 

'. 

5. W- $1d AI:Jdn!oN of Applfcoot - The name of tile firm or persPn IIlld iKkIrKs shown in ywr appllcatiqa h tile per'Of! Of' firm 

to whom the regiStration will be IssuOO. If you are acting: in behalf of another porty,.yoo IIOGt 8I,Ibmit authorization from 

• that partY to act for them In registration matters. An applicant not ruldino in the United States II't.l$t4!llaw an 

authorized ~t rdidlng In the unltt!d States to IIct;or them in all registration ootters. The nMII! tmd c~Ictte lNIilino 

.address of such an agent IWSt a<:cOO'pGny this cppllcotion. 

6. Expedited 

to existlns 

Review 

Nl91stf'etions, 

- FfFAA saction 

that er~ 

3 (c) 

similar 

3 (Il:) 

or 

pravides 

identical 

for 

to 

expedited 

other pesticide 

revltii of 

products 

applicatlOO$ 

that are 

for 

currentlY 

registration, 

• .Jetlistercd 

01' ~ 

with. 

the EPA~ In order for your appllcatlon to be- eligible for expedlted revl~, you ~t previde WI witl'l"tite EPA Registration 

Mi.lWer and product na.'f!Q of the prO<luet you believe is similar to Of' ldentiul to yoor prodl.let. The Pl"oduet III1Jst be: 

similer'tlr identical In both fonwlht;Grl lind labeled USIIIL 

SECTION II - This s@ctionmu,t be cOlIPleted for all &pplicatioru. submitted to IIIOOf'd tile regi!:t{'lItion only of tl 

currently register«fproduct (,\m(!ndmmt) , far j!j rtfiu!:;mis:t;fcn in reGpoMe tQ lin A9ency luter, for notHlt<lltiOlUl to tile 

A~y, for the subnisslon of tilWl prfnted llibeling, for reregistration Mod for any other action that p.l!rulni' to a f!?fJcHip 

!f!·rti!i'~~. Ihls ~(;Ct!on fIt!!2! 12.lli!: u~oo for a rww application for registration. 

l. $lbject of SIhIiSGion' Check the: applicable block and provide tile A\lMC'( letter date if appropriate. Provide a brief 

rue:plantt'ftlto-l1f the PJl'poae(&) for the subml.!lsion. such as "the Mtlitlon of a site, pest or crop (spt!l::ify)"; ,,~ tile 

Confidem.oi •• $tll!t~"""Fonrula by ..... ; "reregistration sutmlssiOf'\I!; 9_ral label revls.1on of use direetioos." Attach 

• "epo:r.~ ~ If ~itllmol IIp.l!ce Is- M«ied. 

• • • •• SBCTIOl1.~II £r4CtKaginq and Container InfOrmation) . this S@ctlon nust be cOirpIetoo for all 

applications ".,tted' ,jp·cCl"otWCtion with new rcgistratlon or applicable ~ts. 

1. Type ot~fns - a~ the appt"opt"Iate bllX:k If Y«JI" product will be p0Ckagcd In the indicoted packaging tyPes. 

Indlcat. the site ttf tlte Ir.dlvidutill packets and ntl!'ber per reUlIl container. 

2. Type- of .retail COOtai':"r I!'Idicate type of conhiner In whlch prodJct will be INIrl:eted. 

3. llDC4tf"'·CII let CGntents - $pe<:ify the net contents of alt ret4il containers for your product. 

4. Sizees)·4fI'J:daiL Container - Specify the net conteots of all rotail containers for yow prOOill:t. 

S. Lce.t[f'! <i.~ DircctfCM • lndlcate tile loeati~ of the we directions for your p~t. 

6. Kannel'" '"' wbidJ l~l Is affbed ta pro:xb:t . lrodlcote tile method product \eJ:xo.l 16 .ttachlld to retail container. 

SECTION IV (Contact Point) - This Sru::tlon IWSt be ctq'lleted for all Applications for R&g;Istratlon actions, 

I.e., new productG registration, rHubnfs8ion, ul\le-too," reregistratfoo, etc. 

l·5. self·explanatory. 

6. EPA "', only. 148 
------._ .... _ .. _ ..... _ .... _._._ ... _------_ .... _ .... - ... - ~-

~- , . 

(ftO RHON.E-PO(JLENC ,~/~~~ - ,""'"' 'If 

• 

• 

RHONE-POUI-ENe AG COMPANY 

ETH-92- i G 

Oclober 2:, 1992 

l), S, Environmental Protection A.gene! 

Ofiice of PesUcid'.? Program DOCl.ITifnt Pl"oCt?'ssinil Desk 

Koorr 266 A, Cryst<'ll 1"1011 No.2 

1921 Jefferson D::Jvis Higrlway 

ArlIngton, VirginlJ 22202 

Attent1on: CynthIa Glles-Parker 

Product 1~I,m21g0r (22) 

Fungicide HerblCide Brana, 

PegistraUon OiV15101) UI7SQ3() 

m:· UDe; j\rr,er;drt1(>nt f 01' Prt-}) (!) c:'ar;cJ Ether;·hor, tor cotten 

EP/\ r{eg_!'\c 264'/[15 

l\i>pend8d is elf) applic9t h.'n to dr(a':CI·j the PrE'P late! by 8dd\l\g a lose ,,:-colrmeM1Jtion ror 

tCZiac[o rhls use I:~ (1)!T(>(ltly reglsll'l"ed 01\ our Ethrel Plant regulator Label {EP!\ Heg. No 

26.t!-2G 7) \'1(; hJvi? fr,;)intameo thc· SJn'e '..;5(> diie(tlOrL$ and JI-:Ho'nded I'ate::; If) CDmperLsate 

ror the change ill the pounds activE' con[airled Ifl the Prep and Etf;rt.'l formulat Ions Both 

labels,novi recommenu the same (jrrolJnt cf i1CUV0 ingrodlent per Jere for 8ppl\catl0n to 

tob,ICCo 

\'/r; are al$"" renuesl.lng an clltema.t0 brancl ncrt,e fOI- Prep to 3d;Jfi:':;':> n-H? addle lon of tobacco 

The alternate brJIl(i name Is Prep branrJ Ctnepl,ol'l fer CoLtOI, ZInc: lob;:KCO I r vou have- any 

(lUtsl ions 8 ]eelS'? CrYLtact rre- profflpt Iy H\'ink yc·u for V'JUr aSsistJnc;:. . 

\.,·'arrel1 A D:;iVIS 

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GESU,nCh :;~'.\rjG,_~ I',V'>!< '1 __ 

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149 
• 

.p REP TM BRAND ETHEPHON FOR COTTON AND TOBACCO 

For Commercial Use Or Agricultural Use Only. Not For Residential Use 

ACTIVE INGREDIENT: Ethephon (2·Chtoroethyl) phoSphonic acid' ................. , ..................................... ,55.4% 

INERT .............................................................................. 44,6% 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

PRECAUCtON At USUARtO: SI ustod no 100 Ingles, 00 use est. prodUdO hasta quo III informacion on Ia otiquota I. haya sido oxplicado 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EYES: Hold O1felids open and Ilush with a gentlo stream 01 walor lor at least 15 minutos. Got modical attontion, preferably an 

ophthalmologist. 

IF ON SKIN: Immodiately wuh skin with plenty of soap and water. Romovo contaminated clothing and shoo$.. Wash clothing 

separately beforo reuse. 

IF SWALLOWED: Do not induoo vomking. Promptly drink a large quantity of milk. egg whit". gelatin solution or if Ihas. are not 

avallablo, drfnk large quantities of wator. Avoid alcohol. Call a physician immDdiately, 

IF INHALED: Remove victim to frash air. If not broathing. givo artificial rospiratlon. Administer oxygen if necessary. Got modica! 

attention. 

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

CORROSIVE. CauSOl (fj8 and skin damage. May be fatalff absorbed through skin. Harmful if swallowod or inhaled. Avoid breathing 

• 

spray mist. 00 not get in eyes. on skin or on clothing. Woar fuR length trousers, long slewed shirt. protoctivo gloves. and goggles or 

face shlokl when handling. Change 10 clean work clothes daily. Wash thoroughly with soap and water after handfing and beforo eating. 

or smoking. Remove and wash contaminated clothing boIoro rouso. Koop away from dam.stir:: animals. 

NOTE TO PHySICIAN 

Thera Is no spocIflc antidoto. Ailirealmont should be based on obsorvGd $lgns and symptoms of distress in Iho paliont. OVoro:tposur. 

to materials other than this product may have occurrod. 

'Victims of sever. overexposure, by inhalation, should bG kept under medical absoNation lor up to 72 hours for delayed onset 01 

pulmonary edema. In a victim of over-oxposuro by iogostion, careful gastric lavage is raquired duo to tho posaibmty 01 stomach or 

esophagoal perforation. this matarial is an acid, but use 01 alkaline 8ubstanoos to noutralize it Is contraindicated. 

• • ENVIRONMENTAL HAZARDS : ••••• 

00 not apply diroctly to water Of wetlands (swamps. bogs, marshes. and potholes). Do not contaminate waler whaQ ~sing 01 

equipment washwators. •••••• • ••••• 

00 not contaminate wator used for irrigation or domestic purposes. : :: • • • •• • •• •••• ••• USE PRECAUTIONS :: ••• 

Do not apply PREpn<i brand Ethophon Cotton BoN Openor through any typo of Irrigation systom. •• • ••• : 

Avoid spray d,ift to noorby crops as this produc1 wUl cause modifications in plant growth. Plant injurY 0; rGducod yields "'vill result. 

•• • Do not plant another crop within 30 days after Ireatmont ••••• • •• 

Mix only tho amount of spray you oxp&d to usa each day. Do not sHow mixGd solution to $land ovornight. •• • •••• 

•• • 

•• • • •• 

150 
, DIRECTIONS FOR USE 

II Is a violation' of Federal Law to UN this product In a mann.,- inconsistent with Ita laballng. 

Rnd entire labill bafo,. using this product. 

REENTRY STATEMENT 

MixotS, loaders and applicators must woar a fun faco shield, Ioog ttousars, long sleoved shirt, gloves and boots 10 avoid as much skln 

and eyo contact as posslWe. 

00 not entor treated liolds within 24 hours aher application unloss protectivo clothing is wom. 

STORAGE 

Do not contaminate water, food, or fead by storage or disposal. 

co'.~;n~' is broken or contents have spillod, foUow all precaolions indK:atod above and clean up imm«fiatoly. aefore clOMing up, 

length trousers. bog sleeved shlrt. protoctiva gloves, and goggles or face shield. Soak up spm wkh absorbent modia such 

earth ar other sultai»e material and dispose of waste at an approved waste disposal facility. 

DISPOSAL 

wastes are acutely halardous. Improper disposal of excess p8slicide, spray mixture, or rinsato is a violation of Federal Jaw. 

Wldte. cannot be disposed of by UM according to label instruction'S, contact your Stato Pesticide or Environmontal Control 

or the Hazardous Wasta ropre&Ontativo at the near.Sf EPA Regional Olfico for guidanco. 

GENERAL INFORMATION 

COTTON 

, . a sanitary 

A foliar spmyol PREPN brand Ethephon will accGlGrata opening of mawr. urlOp(lnOd cotton bolls and enhanc. dofo/lmion which can 

rosult in earlier harvest with an iocroased reoovorabfe yield. PREf'N brand Ethophon tteatment on cotton allows incroased efficioncy 

from a once~vor harvest. 

TOBACCO (FLUE~CUREO): A lofiar spray of PREPN brand Ethephon promotes early, uniform "yellowing~ of maturo lobacco. 

PREpnI reducos curing titrKt, allowing mora el1icient use of curing bam spac.. and increased control over harvest schedules. 

SPRAY PREPARATION 

Add tl2 to 314 of the required amount of wator to the sptay tank. Slart agitation. Add the required amount of PREPN brand Ethophon, 

and lho remaining amount of waI.r. Proparo only as much spray solution 8$ can bo usod on too day of mixing. 00 not aUow spray 

solution to stand ovemight. 00 not spin the concentrated product on spray oquipment, or any airplane parts. 

ANY SPillS SHOUlD BE RINSED IMMEDIATELYWffil PlENlYOFWATER. 

Use of a nUrH tank is highly recommended lor avoiding JXlssibio spills 01 concentrated formulalion on spray equipment or any airplane 

parts . 

• 

COMPATIBfLITY , 

PREPTN brand Elhophon is compatible with DEFt, fOLEX&', DraW. Harvade3· Mothyl Parathion, Guthion', and Malathion·, and may ba 

appiod in &OqO&l"lCOO( as a tank mixturo (00 NOTTANJ( MlXwtlli OEStccANTS F COTTON IS TO BE SPINOLEHARVESTEO). In 

some cases slight rGductkln In boll opening response hu boon observed when tank mix.s with deloliants ware used. 

Good agitallon In the spray tank is essential and a tank mixture should not be allowed to stand without agitation for more Ihan 510 10 

minutes. Road and observe all appropriate !abol us. dlroctions and precautions lor tho defoliants and Insodicides used. 

NOTE: Undor certain conditions. tank mixtures 01 PREpnt brand Ethophon with doolo::ants containing sodium chlorate could 

result in tho formation of hypochlorous acids which on healing wit( emit toxic chloride fumes. 

EQUIPMENT CLEANING 

Because of the acidic nmur. of this. product, prolonged exposure to spray dopos/t will damage acrylic plastics, Cfrtain.paints, and 

metals. • ••••• 

• RlllSethoroughly with a detergont and water all oxposed 8ClYlic plastic-typo materials (e.g., aircraft windshields), l/iQg,palnted surfaC&$ 

within an hour after exposure 10 spray deposits. •••••• • ••••• 

At tho end of each day, rinse thoroughly with a detorgent and water aUth. metal parts of tho alicraft aoo the asaociatod $pray 

equipment exposed to the spray deposits. • • ••• •••••• ••• •• ••• • • •• •••• 

• • 

••••• •• • • 

•• • •• ••• . • •• , . •••• 

. , . • • • •• 

151 
EXPECTED PREpm ONE SPRAY VOLUME APPLICATION 

USE CONDITfONS RATE GALLON (OalafA) TIMING 

PREpm 

,LBS A.1. Ac, .. AI," 

PREprw Hot and dry soa-F or 11/3 1.0 6 Apply when the number ?f 

Boll Oponer· higher maW'. uno".n.d bol:li; 

Dry and 75 10 80°F 2 1.5 4 f5·50 2 ·5 

sufficient to produce 

d8$Jred crop. SGO below 

Cool but above SS-F 2213 2.0 3 !i;j' of boll maturity. 

! Rank ""Hon 2213 2.0 3 ~,~ ~ :"1;:':'" 

PREJ»W + High soil moisture ,/3 0.25 2' 15·50 5~ to Apply 4 to 7 days prio~ to 

FOLEX· High fertility 1e .... 1 PAEpni boll . 

0.lolla"1 Tank Rank cotton appl""ion. To be US~~: Mix a' 'treatment 

n~.i~.~~.of PREpN 

PREpn.+ Dropp2 High soil moisturo 1/3 0.25 24 10 ·50 3 ·10 ~y " to 7 days prio~ to 

Defoliant Tank High lartllity lovel PREpnI boll . 

Mix Rank cotton application. To be uS.ad.~ 

a ser~ ~!(.atmell!.·I~~~ not in of PAEpn. 

Pr.·Condf1lonar Hot,dry, above SWF 213 0.5 12 I ~PJ>Ir.4 10 7day. p'io~IO fo, DefoU_tlon Cool, above ssoF 1 1/3 1.0 6 f5 ·so 2·5 II . lOp 

Rank cotton 1 1/3 1.0 6 ~,~p . " of !,,"Iom c,~p 

~nd ~lIow$ 10' i 

·Pretreatment With Defoliants Prfor to PREpno: BOll Opening Treatment 

If the cotton is overly rank or laying down in fho mlddl •• and good spray coverage of the bolls with PREPD4 is difficult, a pretreatment 

with defoliants will be useful fo improve boN coverago wilh PAEf»M. Use dosage ratDS of PAEpn. brand EthophOn Cotton BoU OponGr 

recommended for boll opening. Read and obsorve an appropriato label use directions and precautions for tho dofoliant usod. 

"In California and Arizona use a voklme 01 flO 10$$ than 5 gaHons par aero lor aoriat applications. 

Boll Maturity 

• 

A boH is mature whon it is too hard D be oontod whon squeezed botwHO thumb and fingers, too hard to be sliced with a sharp knife, and 

when the seed coat becomes light brown in color. 

Use Limitations 

Do not oxCOGd a maximum of 2.0 lb. aiJA for combined us .. of PREpnr par acre per year. 

eon Opooing: Do not tank mix: PREpN brand Ethephon with a dosiccant H tho ootten is to be $pindlo harvested. 

Pr • .condition for Defoliation: 00 not tank mix PAEpnt w~h dosic:cants unfess ptant dosiccation is required. Do not use a dafoHant 

before tho,. is sufficient maturo unopened bolls to produce tho desired yiokf (see GonMallntonnation section on how to test lor boll 

maturity. 

WHEN TO HARVEST COTTON 

• • 00 not harvest cotton $OOnor than 7 days aftor a treatmont with PAE.Pm brand EthDphon CoUon Boll Opener. : ••••• 

Ob$orvo the troated crop and harvest whon opIimum boll opening has bean reached. Too earty haIVost might roowaU1e lull advantago 

of the treatmont and too late a haMlst may tosuh in roducod quality and loss 01 lint which wilt drop f;:WJbG plant.· ••••• 

• •• • •• • 

• • 

•••••• 

• • • .. • 

.. . •• • · .. ••• • •• ••••• •• • • •• • ••••• · •• .. • •••• 

.. . •• • · .. 

152 
PREpllol .s~r.y 

Crop Plnta/Acre ° Acr. 

Directed Spray 1 If.l 5O-1l<J 

Application 

Over-The-Top 1113-2213 4O-1l<J 

Application 

USE LIMITATIONS 

TOBACCO 

(Flue·Cured Only) 

Specific Direction. 

Use drop nozzles, TG Of OC $pray tips doslgned to apply 50 • 60 

gpa al 35-40 psi and al Irac10r speed of 2·3 mph, Use 

2 nozzles par row; one on each side of th& row droppod low enough to direct 

the spra:_~o the loavos to be ripenod and harvested, Thorough spray ~rth a dilectod spray. be sure to harvest all leaves 

Treat only when leave. remaining on the stalk are maturo. To ensure 

romaining leaves- are malure, lost spray several tobacco plants as 

doscribod under tho section ·Proper TIme of Treatment.· U .. lhe IowGr rato 

in a normally mature crop wh.., oxporionco Indicates thai minimum ripon'lng 

inducement is requited. Use tho higher rale when the crop Is heavy and has 

a lendency 10 be more rank or when tempor81ures are Iowar Ihan normal. 

Always teat spray to do-tetmine If Ihe tobaoco is mature enough to respond 

to treatment with PREprw brand Ethephon. 

Apply OVO,4h.-Iop PRE,,", brand Elh~~~~~ Ii" misl"~ ~~~ nozzles (ono nozzlo lips ovO/' tho oente,. I rl.~ 

so a" loav •• aro cove,ed . U ... ~ ::' .;'. ~':.om 

00 not ~ PAEPlW brand Ethophon to immaturo loavos as this can rasuh in unsatislactory coloring, weight \o$S and redlJOOd leaf 

quality. 

00 not allow the crop to over ripen In the field after using PAEprv brand Ethephon. since this may cause soma reduction in ylekl and 

quality. 

00 not treat beforo anticipated major storm which could provon! harvest and msu!!: in crop loss. 

Do not apply PREP."M brand Ethephoo ~ rain is oxpClCtGd within 4 hours. 

APPLfCATIOH TIMING 

Suooossful results with PREplW call for traatmenl whon loaves are mature, no1 overly rank green when sprayed. To easily determine 

the proper treatmenl11mlng and tho numbor of leaves por stalk roady for harvest, tost spray several plants In more than onelocalion in 

each field and abselVatho response. Mature .avos will begin to yellow in 24 to 72 hours. Test leavos that fail to yellow in 72 hours are 

not mature and aro not ready for PREprv brand Elhophon treatment. Wd a few days to parmit further natural maturing, Ihen mako 

another tesl spray or "maturity" check, 

Whon you have confirm&d tho numbor 01 10 avos par plant that will color, you can detarmine tho numbor of actos to treat In order to lill 

tho barn . 

• 

Preparo your test spray by mixing one teaspoons of PAEpn! In 1 qU~rt of water. Spray oach test plant with about t oz. of this mixturo, 

covering an Ioavos with a fine mist. PREprw: brand Ethephon will nat color Immature sprayed loaves. 

WHEN TO HARVEST 

All maturo, sprayed loaves wilt begin to oolor within 24 to 72 hours after PAEpnl brand Ethaphon appUcation, Tho yellowing proces.s is 

weathor dependanl; cool weather will de-lay, while hot, sunny woather can speed up the proooss. HalVest treated tobacco when laaves 

havo reached the dosired color intensity, 

Do not allow tobaoco 10 becomo over ripe before starting harvost, Leaf drop can occur whon tobacco Is over ripe and left on tho stalk. 

H a number of the bottom leaves havo yollowed at the tirM of traatmont. they should be harvested pOor to spraying with PREptIo( brand 

Ethephon. 

WIth an ovar-the-top application. harvesting can commence 24 hours aftor PREplW brand Elhophan applicalion:«t~ng on wearhor 

conditions Of to avoid ovar ripe IObaa:o, Tobacco halVastod 24 hours aftor trealmont will requiro more time in tho coloring pOuo of tho 

curing prooass. • ••••• 

CURING PREJ'n' TREATED TOBACCO : •• :.: •••• 

CUring procedures are 8$ much an art as a scionco and each cur. must be judgoo on the basis otto!:facto conditiof'!, intervaJ bolW09n 

troatment and harvest. weather and type of curing facility beforo proscription temperature.m .vlnlllatp\ sel1edules can be 

estabUshad. To obtain maximum quality. car. must be taken to observe and control1he curing proqess-eclosely, etpGCially during the 

late "ooloring" and early .drying. stages 01 the loaf. •• • •••• •• PREJ»W brand Ethophon treatod tobacco will havo started the coloring proooS8 whon harvested, rellacthOJho time r~ in the 

coloring phaso of curing, Treated tobacco should be dried faster. If lobacco l&aves aro green or CQ~aome gr80tI when haMIstod, 

it may be necessary to color Ihom for a low hours. ti theloaVCl$ are oomplotoly yollow. lemperature and vontllatltn ~ be adiustGd in 

iii mannor to dry Ihe tobaoco as last as possible without scalding. Onco the leaf is dried (314 dry), you should fol~"Mmai procodUr9S 

for coring. Since PREptw brand Ethephan troated loaVes cure faster, treated and untreated leav6s should not ~<:ur.ct together in the 

samo bam. ~ •••• 

153 
LIMITED WARRANTY AND DISCLAIMER 

Tho manufactuntr WaJTants (al that thJs product conforms to tho chemical doscrfption on tho label; (b) that this product Is reasonably lit 

: for the purposos set forth io the diroctJons for use whon it is used in accordance with such directions; and (c) that tho directions, 

warning and othor statements on this fabet are based UfXH1 responsitm experts' evaluatlon of reasonable tms of effoctiveness. of 

IOXiclty to 1aborat0f)' animala and to plana. and of rtleldUO$ on food crops and upon reports of fiold experionoo. Teats have not boon 

made on all varieties Of In all states or und&r all condltkmG. THE MANUFACTURER NEITHER MAKES NOR INlENOS. NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE, ANY OTHER WARRANTIES. EXPRESS OR IMPliED. AND IT 

EXPRESSLY EXCLUDES AND DISCLAIMS ALlIMPUED WARRANTIES OF MERCHANT~A81l11Y OR FITNESS FOR A PARTICULAR 

PURPOSE. 

THIS WARRANTY OOES NOT EXTEND TO, AND THE BUYER SHAll BE SOlElY RESPONSIBLE FOR, ANY AND All lOSS OR 

DAMAGE WHICH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE LABEL 

DlRECTlONS, WARNINGS OR CAUTlONS. 

BUYER'S EXClUSIVE REMEDY AND MANUFACTIJRER'S OR SElLER'S EXCLUSIVE LlABlUTY FOR ANY AND All CLAIMS. 

lOSSES, DAMAGES, OR INJURIES RESUlTING FROM THE USE OR HANDlING OF THIS PRODUCT, WHETHER OR NOT BASED IN 

CONTRACT, NEGLIGENCE smlCT lIABIlfIY IN TORT OR OTHERWISE SHAll BE LIMITED, AT THE MANUFACTURER'S OPTION, 

TO REPlACEMENT OF, OR THE REPAYMENTOFTHE PURCHASE PRICE FDA. THE OUANTITY OF PRODUCT WITH RESPECTTO 

WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHAll MANUFACTURER OR SEllER BE liABLE FOR SPECIAL, INDIRECT OR 

CONSEQUENTlAl DAMAGES RESUlTlNG FROM THE USE OR HANOUNGOFTHIS PRODUCT. 

NDTlCE TO BUYER 

Purchase of this product does not CQnfG( any rights under patiGnts govorning Ihis product Of tho use thoroof in countries outside of tho 

United States . 

• 

lDEF and Guthicn are registered trademarks of Boyar AG. Germany. 

20ropp is a rogistGrGd trademark of NOR·AM Chemical Company. 

3Jiarvade Is a registered trademark of Uniroyal Company. 

• 

4Malathiorl is a trademark of American Cyanamid Company . 

RhOne-Pouteoc Ala Company 

P.O. Box 12014. 2 T.W, Alexander Drive 

Research Trianglo Park. North Carolina 2n09 

PREP Is tho trademark of Rh6ne-Poulenc lor Ethophon CoHon Boll {)panG( 

FOlEX Is a regist&IGd tmdernark of Rh6ne·Poulonc, 

PREpnt brand Ethopi1on for Cotton and Tobacco (PENDING) Submitted tOI23J92. 

•••••• 

o 0 0 o 0 0 

o 0 

•••••• o 0 

o 0 

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154 
1'R E P TM BRAND ETHEPHON FOR COTTON AND TOBACCO 

For Commercial Use Or Agricultural Use Only" Not For Residential Use 

ACTIVE INGREDIENT: Elhephon (2·Chloroethyl) phosphonic acid" ........................................................ 55.4% 

INERT INGREDIENTS: ........................................................................................................................... 44.6% 

-ThIs product contains 6 pounds elhephon per gallon. 

EPA Reg. No. 264-418 EPA Est. No. 264-PA-Ol 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

PRECAUCk)N AL USUARfO: Si usled no lea Ingles, no usa osto prodUdo hastll qua III informacion on la oliqueta 10 haya sido &xpJicado 

us. J I i 

U.S. Patents ,188 andI4:.2"4,,:.S,9. No Ilcons. Is granted to use this product J other than tho·'··-·'" ·"St:''''·':.·-$ or lor any 

use nol contemplated by this label. liability for palont infringement may rasuK from use or salo of this product outside tho United tit Slates. 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EYES: Hokl eyelids opon and flush with a gontlo stroam 01 water lor at lansl 15 minutes. Got modical attontion, proferably an 

oph1halmoJogist. 

IF ON SKlN~ ImmociiatGly wash skin wtth plunty of soap and water. Remove contaminated clothing and shoos. Wash clothing 

separaloly before rouse. 

IF SWAUOWED: Do not induce vomiting. Promptly drink a largo quantity of milk. egg whites, gelatin solution or ilthese aro not 

available, drink largo quantities 01 wator. Avoid aloohoJ. CaU a physician immodiatoly. 

IF INHALED: Remove victim to tresh air. Ii not broathing, give artificial raspiration, Adminisler oxygen if nr;cossary. Get medical 

altention. 

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

CORROSIVE. Causes eye and skin damago. May be lataJ if absorbed through skin. Harmful if swallowed or inhaled. Avoid broathing 

•

spray mist Do not got in oyes, on skin or on clothing. Wear fuJilongth trDusors.long slo8vod shirt, protllCtiVA gloves, and gogglos or 

lace shield when handling. Change to cloan work clothes daily. Wash thoroughly with soap and water aftor handl1!l9 and beforo oating, 

or smoking. Romovo aod wash COf'Itaminated clothing ooloro rouso. Keep away from dome-stic animals. 

NOTE TO PHYSiCiAN 

Thore Is no spocific antidoto. All troatmont should be basod on observod signs and eymptoms 01 distress in tho pationl. o,.oroxposuro 

to materials other than this product may have occurroo, 

Victims of severo ovoroxposure, by inhalation, should ba kopt undor modical observation lor up to 72 hours for delayed onsot ot 

pulmonary edema. In a victim of over·exposure by Ing051ion. carelul gastric I<wage is required duo to tho possib!~ .tstomach or 

esophageal perforation. This material is an acid, but use 01 alkaline substancos to neutralizo it Is contralndicat&ll . 

ENVIRONMENTAL HAZARDS •••••• • •• 

•• •• 

• • •••• 

Do not apply directly to wator or wetlands {swamps, bogs, marshes, and potholes}, 

oquipment washwaters. 

• •• • Do not contamitlale water whp,fl dl§posing 01 

Do not contaminate watG( used tor irrigation or domostic purposes. 

• ••••• • • 

• ., • 

••••• USE PRECAUTIONS : : 

•• • 

• •• 

••• • 

• • •• 

• •••• • Do not apply PREpn.! brand Ethophon Cotton Boll Opener through any rypa of irrigation system. . 

• •• , . Avoid spray drift to nearby crops as this product will cause modilications in plant growth, Plant injury or roducad yTdllI! will result. 

00 not plant another crop within 30 days after Iroatman!. : " •••• . Mix only the amount of spray you oxpect to use each day. Do not allow mixed solution to stand overnight. 

155 
DIRECTIONS FOR USE 

It I •• vlolatlo·n of Fedora' Law to use thla product In a manner Inconslstant with Its I.betlng. 

Read entlr. laba' bofor. using this product. 

REENTRY STATEMENT 

Mixers. loaders and applicators must WGar a lull faco shlold. bng {rouSIlrs, long slaavod shirt. glovGS and toots to avoid as much skin 

and ayo oontact as possiblo. 

00 nol onlor treated lields within 24 hours aftor application untoss protectNO clothing is worn. 

STORAGE 

Do not COnlaminale wator, fOOd, or lood by slorage or di$posal. 

If container is broken or contonts have spilled, follow an preocautions indicated above and c10an up immediately. Safore cleaning up. 

on full longth IroUSOffi, long steovod shirt, prot&CIivo gloves, and goggle. or facs shield. Soak up spUt with absorbent media such 

sand, earth orothar suitab!o material and dispose of wasta at an approved waste disposal fadtity. 

I~!~~~~t~! DISPOSAL IF wastos are acutoly hazardous. Improper disposal of OXCflSS pGslicldo, spray mixture, or rinsate is a violation of FOOQral law. 

n these wastes cannot be disposod of by usa ac<Xlroing to label instructions, contact your Slate Posticido or Environmontal ContrOl 

Agoncy or the Hazardous Waste reprOS8ntativo at the nowest EPA Regional Offlco for guidance. 

CONTAINER DISPOSAL 

equivalent) lhe empty containors. Then olfor lor r and' of in a sanitary 

GENERAL INFORMATION 

COTTON 

A foliar $pray of PREP"" brand Ethophon wlU &cc4iorala oponing 01 mature unoponod cotton bolls and onhanca defoliation which can 

reauR in eatlier harvaat w~h an incraased rocovorable yield. PREpm brand Ethaphon treatment on rotton allows Increased efficiency 

hom a once-over haivost. 

TOBACCO (FLUe-CURED): A foliar spray of PREPl10I brand Ethephon promotes early, uniform "yeUowing- of mature tobacco. 

PREp"N reduces curing time, allowing more efficIent use 01 curing barn spacG, and increased control over harvest schedules. 

SPRAY PREPARATlON 

Add tl2 to 314 01 the requiroo amount of wator to the spray tank. Start agitation. Add tho requiroo amount 01 PREpnt brand Ethophon. 

and the remaining amount 01 water. Prepare only as much spray solution as can be usGd on tho day of mixing. Do oot allow spray 

solutlon to stand overnight Do not splH the concentrated product on spray equipmont, or any airplane parts. 

ANVSPUS SHOULD BE RINSED IMMEDIA1aV WITH PLENlY OF WATER 

Use of a nurso tank is highly r&COmmended' for avoiding possiblo spills of concentrated fOfmulatlon on spray oquipmont or any airplane 

par1s, 

•

COMPATI BILITY 

PREprw brand Ethophon is rompatible with DEFt, FOlE}{$, DraW, Harvade3· Methyl Parathion, Gulhian', and Malathion'\ and may be 

appUad in sequence or as a tank mixturo (DO NOT TANK MIX wrrn DESICCANTS IF COTTON IS TO BE SPINDLE HARVESTED), In 

oome casos slight roductioo in boll opaning response has boon observed when tank mixos with dofotianl.$ were used. 

Good agnation In tho spray tank is essontial and a tank mixturo should not bo atlowad to stand without agitalton for moro than 5 to to 

mInutes. Read and obsorve all appropriate labol use diroctions and precautions lor rhe delotianl$ and insocticides usod. 

NOTE: UndlH" certain cond~ions. tank mixtur.s of PREptw brand Ethephon with dD$k:cants containing sodium chlorate could 

msul( In tho formation of hypochlorous adds which on heating wiH emit toxic chloride fumes. : ••• :. 

EQUIPMENT CLEANING • 

Because oltne acidic nature at this product. prolonged exposure to spray doposlt wilt damago ac~lic plastics, CM1t"a.Trf paints, and 

metals, ••• :.: •••• 

• •• • Rinse thoroughly with a dotergent and water all exposed acrylic plastic-typo materials (o.g., aircra.ftwindstlields~JlndJl4intod surlacos 

within an hour ah.r exposure to spray deposits. ..: •• : : •••• 

At the and of Nch day, rinse thoroughly with a dotergent and wator all tho metal parts of the alrc'aItolnd thQ .. s~atod spray 

oquipmont oxposod to tho spray deposits. ••••• • .: 

• • 

•• • ••••• . .. . , . •••• 

.. . . , . . .. 

156 
---------------

COrTON 

EXPECTED PREptw ONE SPRAY VOLUME APPlfCATJON 

USE CONDITIONS RATE GALLON (Gaf./A) TIMfNG 

PREp'BI 

LBS A.I. Acr •• AI~' 

PREpTIol Hot and dry SO"F or I 113 1.0 6 Apply when the number ?f 

Boll Optner· hIgher mafure unopenod boUSI~: 

Dry and 75 to SO"F 2 1.5 4 sufficient to I.'i~~ 15 -50 2-5 

dO';"'<l".Cbo : .. _be~.~ Cool but abovo SS"F 2213 2.0 3 lesl oj I 

Treatmont 

Rank cotton 2213 2.0 3 baUs 710 14 days Gatlior. 

PREPN + High soU moisture 113 0.25 2. 15 ·50 5 ·10 I ~!f~!,~_I~ 7 days prfer. to FOLEX· High fortllity 10'101 bO~_~_ J 

Dolollant Tank 

MIx Rank cotton . To '"'I~'t. I ~ol ;~ , boll 

PAEpnt+ Dropp:! High so~ moisture 1i3 0.25 2' to -50 3* to Apply 4 to 7 days prior to 

O.foUant Tank High fortility leyol PAEpnt boll opening 

MIx To ba used as 

Rank cotton I ~~, i~ p~ol , 

boll 

Pr.·CondIUoner Hot, dry, above 8O~F 213 0.5 12 I ~Pf"t 4 10 7, d~y, ",iO'!~~ 'or Doloff.tlon Cool, above 65"F "13 1.0 S 15-50 2·5 

Rank cotton I 113 1.0 S I ~r~p, ' 

I ~nd ~J1ow~ of f~"O:a;!;':.': 

"Pretreatment With Delollants PrIor to PREpn.! Boll Openfng Treatment 

If the cotton is overly rank or laying down in the middle. and good spray coverage oJ th. bolls with PAEpnI Is difficult. a prel(ealmont 

with defoliants wHi be useful to improve boll covoiago wilh PREpTIol. Use dosage rates of PREP~ brand Ethephon Cotton Boll Oponor 

rACOmmendod for boll opening. Read and observe aU appropriate label use direclions and precautions lor the dofolianl used. 

"In California and Alizona usa a volume 01 no less than 5 gallons per aere for aerial applications. 

Boll MaturIty 

• 

A boll is malure wh4n it is 100 hard to be dantod when squeezed talWeen thumb and lingers. too hard to be sliced with a sharp kn~o, and 

when the ssed coat booome$ light brown in color, 

Usa lImltatfons 

Do not exceed a maxlmum of 2.0 lb. ailA for combined uses 01 PREfmI por acre per year. 

Boll Opening: Do not tank mix PREpTl.! brand Ethophon with a desiccant if tho conon is to be spindle harvested. 

Pre-Condition lor Defoliation: Do not tank mix PREpno wilh desiccants unless plant desiccalion is required. Do no! usa a deloHant 

before thero is sufficlont maturo unopened bolls to produce the dosired yield (see Genorallnformation sectiog on Qow to lost for boll 

maturity. : ••••• 

WHEN TO HARVEST COTTON •••• 

• • 

Do not harvest co«on sooner than 7 days after a treatmont with PAEpnt brand Ethophon Cotton B<:Qro~aor. • ••• 

Observe the troated crop and harv&st when oplimum boll opening has ixlon roachod. Too oarty haNesi ~ht rop~c; Jha tull advantage 

of the treatment and too late II: harvest may result in rGducoo quality and loss of lint which will drop ftOJ2'l'1t'1, plant: •••• 

• ., • 

••• •• 

• • • • •••• • 

••• • 

•• 

•• 

• ., · " . •••• 

. , . • • · " 

157 
PREpN 

Crop Situation Plnta/Acr. 

! Spray 

Application 

OVf(-Tho·Top 

Application 

1113 

t 113 - 2 2f.3 

USE LIMITATIONS 

50 

4C-50 

TOBACCO 

(Flue-Cured Only) 

SpecIfic Dlrectlona 

drop oou!os. TG Of OC designed to apply 50 

gpa at 35-40 psi and at traclor 01 2·3 mph. 

2 nozzles per row: ono 00 oach side of the row dropped low enough to 

the spray to tho leave' to be ripened and harvested. Thorough 

""'~.~'lI. is oMOntiaL With a directed spray, ba sure to harvest aU Io;v.;, I 

Treat only when leaves remaining on tho slalk are maturo. 

remaining leavos are maturo, test spray soveral tobacco 

dG8CribGd In 8 normally under matul1I the section 

crop when ·Propor oxperience 11m. of indicates Treatment." thai usa~:~~5~:~ minimum I 

Inducement is required. Uso tho higher rate when the aop Is 

a tendency to be more rank or when tomporatuIlIs are lower than ':;:;~ I 

Always test spray to delarmlno if tha tobacco is mature enough to rc 

10 traatmant w~h PREpN brand Ethaphon. 

Do not apply PREPTIoI bl'and Elhophon 10 immalure loaves as Ihis can rewn in unsatlslactory coloring, woighllO$$ and rGdocod lea! 

quality. 

Do not allow tho crop 10 over ripon in tho fiold after using PRE~~ brand Elhophon, sine.lhis may causa soma rGduction in yield and 

quality. 

Do not treat boloro anticipated major storm which could pr9Vent harv"1 and result in crop loss. 

• Do not apply PREPN brand Elhephoo if min is ClXpoctGd within 4 hOurs. 

APPLICATION TIMING 

Succo55lu! rosuU5 with PREprw. caUlor treatmont whon IeavGS are maturo, not overly rank groen when sprayed. To easily determine 

Ihe proper troatmomt!mill9 and Ihe number of Ioavos per slalk ready for harvest, 1051 spray sovoral plants in morolhan one Iocalion !n 

each field and observe the response. Mature loaves wWI begin to yoflew in 2410 72 hours. T 051 loaves Ihat lailto ye!bw in 72 hours are 

not mature and are no! ready for PREPm brand Ethophon trealment Wait a law days to pormit lurthor natural maturing. than mako 

another tost spray or ·maturity· chad<. 

Whon you havo confjrmed Ihe numoor 01leav8s par planllhal wiU color. you can dotermlno Ihe numbGr 01 acras 10 treat in order to Iii 

Iho bam . 

• Prepare your tosl spray by mixing onatoaspoons 01 PREprw. In t quart of waler. Spray oach tost planl with about I oz. oIlhis mixture, 

covoring aU loaves with a line mist. PREpnt brand Ethophon will not color immalure sprayed loaves. 

WHEN TO HARVEST 

AU maturo. sprayed loaves wifl begin 10 color within 2410 72 hours after PREf7T14 brand EthGphon appUcatloo. Tho yellowing ptOCOS$ls 

woather dapendent; IXlOI weather will delay, while hot, sunny wealher can speed up tho process. Harvesl trealed lobacco When leaves 

have reached the desired color !nlensity. 

Do not allow tobacco to bocome over ripo befora slarting harvest. Leaf drop can occur whan lobacco is over riP.&: antllolt on the stalk, 

If a number of Iho bottom leaves have yellowed at Ihe Ume of trealmenl, Ihey should be harvested prior 10 spf~·wa~ PREpnt brand 

Elhephon. • ••• 

With an over-Ihe-top appIicalion. harvesting can commence 24 hours afler PREptw brand Elh~aQM:ation ·~ing on woalhor 

conditions or to avoid over ripe tobacco. Tobacoo harvostGd 24 hours after troalmont will roquiro npeotift%G in Iho coloring phaH 01 tho 

curfng procoss. •• • •• •••• ••• CURING PREpni TREATED TOBACCO :: ••• 

Curing procedures are as much an art as a science and each cure must be judgod on Ihe basis 01 tobltx:o conll/tiOO. Ilterval betweon 

Iraatment and harvesl, wealher and Iypo of curing tacillty before proscription lemperature "I:ftt!"t,nll!ation seltodu!es can be 

eslabUshed. To obtain maximum quality, caro musl bo taken 10 observe and conlro! Ihe curing prooesf'CIo$GIy, egpocially during Ihe 

tata ·ooloring· and early ·drylng· stages of the Ioal. •••• • •• 

•• • PREf7T14 brand Elhophon troalocl tobacco will hava started Iho ooloring process when harvosted. reducing Iheljmd'~red!n tho 

coloring phase of curing. Treated tobacco $hould be dried laslor. tllobecoo loaves ara gr .. n or contain some ~n tipon harvostod, 

it may be necessary to color thorn lor a low hours. If Iho leaves are completely yellow, lemperalure and ventilatian nMIt bo adjusted in 

a manner 10 dry Ihe tobacco as last as possible without scalding. Once Iho Ioal is dried (314 dry), you shoukl follow normal prOCCKluros 

lor curing. Since PREpno brand Elhephon Ireated Iaavas curo laster, Ireated and untreated Ioavas should nol be cured logethor in tho 

samobam. 

158 
----------------------_ ...... - -- ~---

LIMITED WARRANTY AND DISCLAIMER 

.)ho manufacturer warrants (a) Ihat Ihis product conforms to Iho chemical dGwlption on Ihe label; (b) that this product is reasonably fit 

loe tho purposes sot forth in Ihe dirGCtions for usa when II is used in accordance with such directions; and (c) that tho directions, 

warning and other statements on this labql aro based upon responsible oxperts' evaluation of roasonablo losls of effectlvenGSS, of 

loxiclly 10 IaboralOlY animals and 10 plants. and of residuas on food crops and upon reports at field axpotlonoo. Teats have not been 

made on aU varioties or In all stales or under all conditions. ll-IE MANUFACTURER NEmlER MAKES NOR INTENDS. NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES. EXPRESS OR IMPLIED. AND IT 

EXPRESSLY EXCLUDES AND DISCLAIMS All IMPLIED WARRANTIES OF MERCHANT·ABILITY OR FITNESS FOR A PARTICULAR 

PURPOSE. 

TIllS WARRANTY DOES NOT EXTENO TO. AND THE BUYER SHAll BE SOlELY RESPONSIBLE FOR. ANY AND All LOSS OR 

DAMAGE WHICH RESULTS FROM THE USE OF THIS PROOUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE LABEL 

DIRECTIONS. WARNINGS OR CAUTIONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, 

LOSSES. DAMAGES. OR INJURIES RESUL nNG FROM TIlE USE OR HANOUNG OF TIllS PROOUCT. WHETIlER OR NOT BASED IN 

CONTRACT. NEGLIGENCE. STRICT lIABIlITY IN TORT OR OTIlERWISE SHAll BE LIMITED. AT THE MANUFACTURER'S OPTION. 

TO REPlACEMENT OF. OR THE REPAYMENT OF THE PURCHASE PRICE FOR, TIlE auANTlTYOF PRODUCT WITH RESFECTTO 

WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SEllER BE LIABLE FOR SPECIAL, INDIRECT OR 

CONSEQUENTIAL DAMAGES RESUL llNG FROM THE USE OR HANDliNG OF THIS PAOOUCT. 

NOTICE TO BUYER 

Purchase of Ihis product does not confer any righlS undor patients governing this product or Ihe use thereof in countries olilside ollhe 

United Slates • 

• 

10EF and Gulhion are regislered Uadomarks of Bayer AG, Garmany, 

20ropp is a registered Irademark of NOR-AM ChemicaJ Company. 

3Harvade is a rogislerod Iradomark of Uniroyal Company, 

• 

"Malathion Is a Irademark of Amorican Cyanamid Company . 

RhOne-Poulooc Ao Company 

P.O. Box 12014. ~ T.W. Alexandor Drive 

Research Triangle Park, North carolina 27709 

PREP is the trademark of Rh6no-Poulonc for Elhophon Cotton Boii Openor 

FOlEX is a registered trademark of RhOne·Poulel'lC . 

PREprw brand Elhophon fO( Cotton and Tobacco (PENDING) Submittod 10t23192. 

•••••• · • •• " 

• • 

••••• • • • • .. • 

••••• • • • • ••••• 

• • ••••• • 

• 

•••• • • • ••• 

• .. . •• • · .. ••• • 

• .. • 

· .. •• • •••• 

.. . . , . · .. 

159 
'. 

PRE P TM BRAND ETHEPHON FOR COTTON AND TOBACCO 

For Commercial Use Or Agricultural Use Only. Not For Residential Use 

ACTIVE INGREDIENT: Ethephon (2-Chloroethyl) phosphonic acid· ........................................................ 5 5.4 % 

............................................................................................................... 44.6% 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

PRECAUClON AL USUARIO: 51 ustod no lOG ingles, no use 0510 producto hasla quo In informacion on Ia allquola kI haya skh> oxplicado 

I 

1fiu~ U.S. .. ~:.:[1~~~~~~~~ USGS are I i Patents ,~:24(i.ii19:, is granted to use this product in countries other than the for any 

use not contemplated by this UabiHly for patont inlringomont may result from U$O or sale of this product outside the United 

eSlates. 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EYES: Hold eyolids oPGn aod flush wkh a gontlo stream 01 waler lor at least 15 minutes. Gel medical attention, prolorably an 

ophthalmologist. 

IF ON SKIN: Immediately wash skin with plenty of soap and walor. Ramovo contaminated clothing and shoos. Wash clothing 

separately before rOUM. 

IF SWALLOWED: Do not indllOG vomiting. Promptly drink a largo quantity of milk. egg whit". gelatin solution or if these aro not 

3ValJab{o, drink large quantities. of water. Avoid alcohol. Call a physician immediately. 

IF INHALED: Remove victim to fresh air. H not breathing, give artilicial rospilation. Administer oxygen if necossary. Got medical 

allanlion. 

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

•

CORROSIVE. Causes eye and skin damage. May be fatal if absorbed through skin. Harmful if swallowed or inhaled. Avoid breathing 

spray mist. Do not get In eyes, on skin Of on clothing. Wear fu!llength trou&ers, long sleeved shirt, protective gloves, and gogglos. or 

faco shi-'d when handling. Chango to clean work clothes daily. Wuh thoroughly with soap and water after handling and before oaling, 

or smoking. Romovo and wash contaminated clothing beforo reuse. Keep away from domestic animals. 

NOTE TO PHySICIAN 

There Is 00 specific antidote. An troatment should be based on obsorved signs and symptoms of distross in the pation!. Ovoloxposuro 

to materials other than 1his plOduct may have occurred. 

Vidims of severe overexposure, by inhalation. should be kept under medical observation lor up to 72 hoUrs for dolayGd onset 01 

pulmonal)' od&mB. In a victim of ovef~axposuro by Ingestion. careful gaslric lavage Is required due to the possibfllY.QCllfOmach or 

.~al perforation. This matelial is an acid, but use of alkaline substances 10 neutralize It Is CXlntralndicated . 

•••• 

• • ENVIRONMENTAL HAZARDS : •• :.: •••• 

Do not apply directly to water or wetlands (swamps, bogs, marshes, and potholes). Do not contamirCate wl6er when disposing 01 

aqulpment washwalers:, •••••• :... • •• ••• 00 not contaminate wator used for irrigation or domestic purpoSGs. • • •• 

••• •• USE PRECAUTIONS • • • • 

00 oot apply PREP"' brand Ethophon Conan BoU Op&nor through any typo oIlrrlgation system. ••••• 

.... . • • 

•• 

• 

• •• •• • Avoid spray drift to nearby crops a5 this ploduct wiU cause modifications in plant growth. Plant injury or roducGd ylulct. will resul!. 

00 not plant another crop within 30 days aftGr treal:monl. 

Mix only lho amount of spray you expect to use each day. Do not allow mixed sojU1ion to $land overn)gh1. 

•• • •• • • •• 

160 
r ... ~ ... - ... --------------------

DIRECTIONS FOR USE 

II '0 a vlol.tlon of Fodo,,1 Law to UN this product In • manner Inconslslanl with 118 labeling. 

R •• d Gnltre label before using this product. 

REENTRY STATEMENT 

Mhc8t"$, loaders and applicators must wear a full face shield, long ltousors. long sleoved shirt, glovos and boots to avoid as much skin 

and oya contact as pouiblo. 

Do not enter Irea100 fiolds Within 24 hours after application unloos protective clothing is worn. 

not contaminato water, food, or feed by storage or disposal. 

oonlaine( is broken or contents have spilled, follow aU precautions indicated above and ckaan up immediately. Baforo deaning up, 

full length fIOUsers, long sloeved shirt. protectivo gloves, and goggles or face shield. Soak up &pill with absorbent media such 

sand, earth or other suitable material and dispose of wast. at an approved waste disposal facility. 

DISPOSAL 

hazardous. Improper disposal of excess pesticide. spray mixture, or rinsalo is a violation 01 Fooerallaw. 

of by UN according to labol instructioos, contact your Stat. Pesticide or Environmental Control 

r&p10&8nlativo at the nearest EPA Regional Offlce for guidanc.. 

GENERAL INFORMATION 

COTTON 

0' and dispose 01 in a sanitary 

A foliar spray 01 PREpn! brand Ethephon will acx:ol«ate oponing of maturo unopened cotton bolls and enhance dolollation which can 

result m earlior harv84t with an increuod recoverable yield. PREPlW brand Ethephon trealment on cotton alkrws increased effICiency 

lrom a onoct-over harvest. 

TOBACCO (FLUe·CURED): A foliar spray of PREpt>I brand Ethephon promotes early, unilorm "yellowing~ of mature tobacco. 

PREPni reducos curing time, allowing more efliciont USfi of curing barn space, and increased conlrol over harvest schedules. 

SPRAY PREPARATION 

Add 112 to 3/4 of 1ha required amount 01 water to the spray tank. Slart agitation. Add tho required amount of PREpnor brand Ethophon, 

aod Ihe remaining amount of watOJ'. Prepare only as much spray solution as can be used on the day of mixing. Do not allow spray 

-solution to stand overnight. Do not spill tho concentrated product on spray equlpmenl, or any airplane parts. 

_ SPilLS SHOULD BE RINSED IMMEDIATELY WITH PLEmY OF WATER. 

U&& 01 a nurn.tank is highly recommended for avoiding possible spills 01 concentrated formulation on spray equipment or any airplano 

• 

parts. 

COMPATIBILITY 

PREPnI brand Ethophon is compatible with DEFt, FOLE)C?I, Dr0pp2, Hatvado3, Methyl Parathion, Guthlon t, and Malathion-'l, and may be 

applied In soquooeo or as a tank mixturo (DO NOT TANK MIX WITH DESICCANTS IF COTTON IS TO BE SPiNDLE HARVESiEDJ. In 

some cases alight reduction in boll opening rosponse has been observed when tank mixes with defoliants wore used. 

Good agitation in tho spray tank is os"nll&1 and a tank mlxturo should not be allowed to stand without agitation tor mora 1han 5to 10 

minutos. Read and observo all appropriate !abo! use directions and precautions for the defoliants and insOdicides used. 

NOTE: Under oortain conditions. tank mixtures of PREP'n' brand EthGphon with desiccants containing sodium chlorate could 

result in the formation of hypochlorous acids which on heating will emit toxic chloride tumes. • • 

•••••• EQUIPMENT CLEANING • 

Becauso oltho acidic nature of this product, prolonged 8xposure to spray deposit will damage acrylic piastics, c,t\IIIfI,pamts. and 

metals. : •• :.: •••• 

Rinse thoroughly with a detergent and watar all oxposod acrylic plastic-typo materials (e.g., aircndi wtndshleIdS}. arld painted surlaces 

wHhln an hour after exposure to spray deposits. •••••• • •••• 

•• ••• At the end of oach day, rinse Ihoroughly with a detergent and watar all the mota! parts- of the airdt,#'Md lhI..s~atod spray 

equipment exposed to the spray doposi1s. ••••• • .: 

• • " . ••••• . • •• , . •••• 

. ,. •• • • •• 

161 
,--- , ... _--- ._ ........ _.--_. __ . ---_. 

COTTON 

EXPECTED PREpm ONE SPRAY VOLUME APPliCATION 

USE CONDITIONS RATE GALLON (Gala/A) TIMING 

r:.EiT":. 

LBS A.I. Acr •• A,..· 

PREpm Hot and dry ~F or 11/3 1.0 6 Apply when the number of 

Boll Oponer" higher mature unopened bolls Is 

Dry and 75 to 8O-F 2 1.5 4 t5·50 2·5 

sufficient to produce the 

dosirod crop. See below lor 

Cool but above 65~F 22/3 2.0 3 test 01 boll maturity. 

Treatment unilorm!y opens 

Rank cotton 22/3 2.0 3 bolls 7to 14 days earlier. 

PREP ... High soU moisture 1/3 0.25 2. 15 ~ 50 5· to Apply 4 to 7 days prior to 

FOLEX· High lertllity level PREpN boll opening 

OafoHant Tank Rank cotton 

application. To be used as 

Mix a S;u;I::ltreatmem wilh, not in of PREpnc boll 

PREpn.t+ Oropp2 High soW moisture tl3 0.25 2. 10·50 3· to Apply 4 to 7 days prior to 

Defoliant Tank High lorlility Iovel PREpnI boll opening 

To be used as Mix Rank cotton 

, ~ot i~ PI~ .0' 

with, 

boll 

Pro-Condllloner Hot, dry, above 80~F 2/3 0.5 12 Apply 4 to 7 daY' prior to 

lor Dafollallon Cool • .wove 65~F 11/3 1.0 6 15·50 2·5 defoliant. Enhances __ !o~ 

Rank cotton 11/3 1.0 6 

crop dalollation i 

delerioration of bottom crop 

sod allows '0' earlier 

·Pretreatment WHh Defoliants Prior to PREPTloI Boll Opening Treatment 

If the cotton is overly rank or laying down in the mIddle. and good spray coverage 01 tho bolls with PREpm Is difficult, a pretraatment 

with dofoHants will be usaful to improve boll coverage with PREPN. Use dosage rates ot PREpn.t brand Ethophon Cotton Boll Openor 

rGCOmmondad tor boll opening. Road and observe all appropriate labol use diredions and precautions tor tho defoliant usoo. 

"In California and Arizona uso a volume 01 no less than 5 gallons- per acre for aerial applications. 

Boll MatUrily . til A bolt is mature wh9tl it is too hard to be dented when squoozod ootwG9tl thumb and tlngers, 100 hard to be sliced with a sharp knife, and 

when the seed coat becomes light brown in color. 

Usa Llmltallona 

Do nat exceod a maximum ot2.0 lb. ai/A tor combined usosot PREpm pol' acro par yoar. 

Boll Opening: 00 not tank mix PREp-n.t brand Ethephon with a dosiccant if tho cotton is to be spindle harvestOO. 

Pro.condltion tor Deloliation: Do not tank mix PREpn.t with desiccants unless plant desiccation Is required. Do not uso a dofoliant 

before there is sufficient mature unopenod bolls to produca the dosired yield (500 Gonerallntormation soctiOll on gow to tost for boll 

maturity. : ..... 

WHEN TO HARVEST COrrON •••• 

• • Do not harvest cotton sooner than 7 days after a troatman! with PREpm brand Ethephon Cotton B4lr~bor. • ••• . ~. . Observe tho treated crop and harvGst whon optimum boll opening has boon reached. Too early ha!VO$t might re,.duco the fuR advantage 

of the treatment and too Jato a harvast may result In roducod quality and lass otlint which wm drop Q~)he plantt •• •• ... ... • • •• •••• 

• • ••••• •• • • .... •• • ~ 

• •• •• • •••• 

•• • • • • •• 

162 
'. 

PREpTiol 

Crop SIIU1ulon Plnt8/Acr. 

Olrectod Spray 

Application 

Ovor.Tho-Top 

Application 

\1/3 

1113-2213 

USE LtMITATtONS 

60-60 

40-60 

tosACCO 

(Flue-Cured Only) 

Spoclflc Olractlona 

Use drop noWos. Choose Of OC spray dosigned to applY 50 

gpll at 35-40 psi and at tractor sp.ed of 2·3 mph. 

2 tho nozzlGs ,pray per to tho row; loaves ono on to oach be sid. ript:nod of tho and row harvested. dropped ~::~~:~i;~:: I 

is er.sGnlial. With a directed spray, be sur. to harvost 

Troat only when loaves romaining on the $Ialk are maluro. To 

romainlng loavo. are mature, lest spray .ovaral tobacco plants 

doscribod unde, tho SGQion ·Proper TIme of Treatment ~ Usa tho lower 

in a normally mature crop when experience indicates that minimum rip<!~;'1Q I 

IndllCGment is required. Usoth. higher rate whon tho crop is heavy 

a tendency to be more rank or wn.n tomperaturos ~u. Iowar than ':::~ I 

Always tosl spray to determino if tho tobacoo is mature onough to rI 

to troatment with PREpN brand Ethophon. 

Do not apply PREpn! brand Eth.phon to immature loaVO$ 8$ this can result In unsatistactory coloring, weight loss and roducod loaf 

quality. 

00 not allow the crop to over ripon in tho Iklld after using PAEpn.c brand Ethephon, sinee this may cause some reduction in yield and 

quality. 

00 not tmat belam anticipated major storm wnk::h couk! prevent harvest and rosult in crop loss. 

• Do not apply PREpN brand Ethept;on if rain is expoctod within 4 houtS. 

APPLICATION TlMtNG 

Successful results with PREplW call for treatment whon leaves are mature, not overly rank green when sprayed. To easily detormino 

the proper troatment timing and the number 01108vO$ per stalk ready for harvest, test spray severat plants [n more than one location in 

each field and cbselVothe respons-e. Ma!ureloavos will begin to yellow in 24 to 72 hours. Test loaves that fail to yellow In 72 hours are 

not mature and are not ready for PAEpnt brand Ethophon treatment. Wait a few days to permit further natural maturing, then mako 

another test spray or ~rnaturity· chock . 

• 

When you have confirmed th8 number of loaves per plant that will color. you can determine the numhAr of acres to treat in order to tijl 

he barn. 

Prepare your test spray by mixing ana toaspoons of PAEpTiol in 1 quart of water. Spray each tast plant with about t oz. of this mixture, 

covoring aU lGaves with a line mist. PAEpn.! brand Ethephon will not color immature sprayed leaves. 

WHEN TO HARVEST 

All mature. sprayed loaves wWl begin to rolor within 24 to 72 hours after PAEprw brand Ethephon application. Tho yellowing procos.s is 

weather dependent; cool weather will delay. while hoi, sunny weathGr can spood up the procoss. Harvost troated tobacco whon loaves 

have roached the doolred color intensity. 

Do not allow tobacco to become over ripe beforo starting harvost. Loaf drop can occur when tobacco is over r~lftft on tho stalk. 

If a number of tha bot1om loaves havo yellow&!! at the timo of troatmant, thoy should be harvested prior to sprayittg with PAEPN brand 

Ethaphon. ,."', 

With an ovar-the-top application, harvesting can commonce 24 hours after PAEpn.! brand Eth~ 'l~ d~~ng on waathor 

conditions or to avoid over ripe tobacco. Tobacco harvested 24 hours after treatment will raquire mare~'" in the cobring phasa at tho 

curing process. ",.,' :',', 

CURING PREptW TREATED TOBACCO :: '<II" 

Curing procedures tile as much an art as a science and each cure must be judged on tha basis of totJCco roodlMIt, i;terval botwoon 

treatment and harvest, weather and type of curing facilil}' before prescription temperature a~'~/Wltilatlon sc'h'edulos can be 

established. To obtain maximum quality, care must bo taken to observe and control tho curing p_.~ t:IoSGIy, esf,locially during tho 

lata ·0010009" and eally '"drying" stagas of tho !eat : , ••• 

•••• PAEpm brand Ethephon treated tobacco win have started tho oolodng process when harvested, reducing the tlmueqVired in the 

coloring phase of curing. Troatod tobacco should be dried fastor. II tobacco teaves are green or contain some gllGOf'l Mon harvostod. 

it may be nocoseary to color them for a fow hours. If tho \aavOtl are oompletety yellow. temperature and VGn1.Uatio'n mMt be adjustad in 

a manner 10 dry the tobacco as fast as possible without scalding. Once the lem is dried (314 dry). you should follow normal procedures 

for curing. Since pREfN brand Ethophon troated !eaves cure fastor. troated and untroatod loaves should not be cured together in tho 

sema barn. 

163 
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.~---.------

LIMITED WARRANTY AND DISCLAIMER 

,:;he manufacturor warrants (a) that this product conforms to Iho chemical description on the label; (b) that this product is reasonably fft 

for the purposos sot forth in tho directions for ute whon it is used in accordance with such directions; and (c) that Ih. directions. 

waming and other statemenls on this label are basod upon responsible experts' eValuation of reasonable tasts at effectiveneas, of 

toxicity to laboratory animals and to p\ants. and of tftGlduos on food crops and upon reports of lleld experience. rests have not boen 

made on all varieties or in all states or under all condKions. THE MANUFACTURER NEITHER MAKES NOR INTENDS. NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES, EXPRESS OR IMPLIED. AND IT 

EXPRESSLY EXCLUDES AND DISCLAIMS AlL IMPLIED WARRANTIES OF MERCHANT·ABIlITY OR FnNESS FOR A PAR11CUlAR 

PURPOSE. 

THIS WARRANTY DOES NOT EXlEND TO, AND THE BUYER SHAll BE SOlELY RESPONSIBLE FOR, ANY AND All LOSS OR 

DAMAGE WHtcH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE LABEL 

DIRECTIONS. WARNINGS OR CAUTONS. 

BUYeR'S EXClUSIVE REMEDY AND MANUFACTURER'S OR SelLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, 

LOSSES, DAMAGES, OR INJURIES RESULTING FROM THE USE OR HANOUNG Of' THIS PRODUCT, WHETHER OR NOT BASED IN 

CONTRACT, NEGlIGENCE. STRICT LIABILITY IN mAT OR OTHERWISE SHAll BE LIMITED, AT THE MANUFACTURER'S OPTION, 

m REPlACEMENTOf', OR THE REPAYMENTOFTHE PURCHASE PRICE FOR, THE QUANTfTY OF PROOUCTWITH RESPECTTO 

WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, INDIRECT OR 

CONSEOUENTlAl DAMAGES RESUlTING FROM THE USE OR HANDLING OF THIS PRODUCT, 

NOTICE TO BUYER 

Purchase of Ihls product doos not canfor any rights under palients governing this product or the use therlKll in countries outside of tho 

United Siaies. 

e lDEF and Guthlon are registered Irnd&marks of Bayer AG, Germany. 

2Dropp is a rogistarad tradamatk of NOR·AM Chomicat Company. 

3HlUVadO Is a rogistarod tradomark of Uniroyal Company. 

• 

4Malathion is a trademark of American Cyanamid Company . 

Rh6n.Pou!enc Ag Company 

P.O. Box 12014. 2 T.W. AJoxaodof Drive 

Ros&arch Triangle Park. North Carolina 2nog 

PREP is the trademark of RhOne-Poulenc for Eth&phon Cotlon BoH Oponor 

FOLEX Is a registered trademark of RM/'lo-Poulenc. 

PREpni brand Ethophon for Cotton and Tobacco (PENDING) Submitt&d 10123192. 

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164 
,P REP TM BRAND ETHEPHON FOR COTTON AND TOBACCO 

For Co";merclal Use Or Agricultural Usa Only. Not For Residential Use 

ACTIVE INGREDIENT: Elhephon (2·Chloroethyl) phosphonie acid· ........................................................ 55-4% 

INERT INGREDIENTS: .......................................................................................................................... .44.6% 

~This product contains 6 pounds ethephon per gallon. 

EPA Reg. No. 264-418 EPA Est. No. 264-PA-01 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

PRECAUCk>H AL USUARIO: 81 uslod no loe ingles, no use este producto haslll qUG 10 intormacion en 18 oliqUGta Ie haya 500 explicado 

uSGS ale 

U,S. ,188 andj-4:24·C~ .• ,9: license is granted to us. this product in countries other than tho lor any 

use not contemplated by this I Liability lor patont infringomont may result from usa or salo of this product outside tho United 

_SlmIGS. 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EVES: Hold eyelids open and flush w~h a gontlo stroam of walor for at loast 15 minutes. Gol modical atlantion, preferably an 

ophthalmologist. 

IF ON SKIN: Immodiatoly Wll$h skin with plonty 01 soap and water. Remove contaminated clothing and shoes. Wash clothing 

separately before rouse. 

IF SWALLOWED: Do not induce vomiting. Promptly drink a large quantity of milk, egg whilos, gelatin solution or iftheso are not 

available. drink largo quantities of water, Avoid alcohol. Call a physician rmmediately. 

IF INHALED: Remove victim to fresh air. If not breathing, give artificial respiration. Administer oxygen if nocessary. Get mooical 

attention. 

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

CORROSIVE. Causes eyo and skin damage. May bG fatal if absorbed through skin. Harmful If swallowed or inhaled. Avoid breathing 

• 

spray mist. Do not got In OVas, on skin or on clothing. Woar full length trousers, long sleevoo shirt, prol&CIive gloves, and gogglos or 

face shield whon handling. Change to clean work dothes dally. Wash thoroughly with soap and wator altar handling and before eating, 

or smoking. Remove and wash comaminated clothing boloro reuse. Koop away from domestic animals. 

NOTE TO PHYSICIAN 

Thera is no specific antidote. AU treatment should bo basad on abselVed signs and symptoms of distress in tho patient Overoxposure 

to material; other than this product may have occurred. 

Victims of severe overexposurG, by inhalation, should be kept undor medical observation lor up to 72 hours for delayed onset of 

pulmonary odema. In a victim of over-exposure by ingtl$tion, carelul gastric lavage is required due to the possibHity of stomach or 

esophageal perforation. This material is an acid, but use of alkaline substances to neutra~ze it is oontraindicated. 

ENVIRONMENTAL HAZARDS 

00 not apply directly to water or wOllands (swamps, bogs, marshes, and pothoios). 

aquipment washwatel'S. 

Do not oontaminate water usoo for irrigatkln or domestic ptJrposos. 

USE PRECAUTIONS 

• • •••• •• 

• 

Do not oontaminate wator wllptl-di!QOsing 01 

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•• •••• Do oot apply PREPw brand Ethophon Cotto;') Boll Opener through any typo of irrigation system. ••••• • .: 

Avoid spray drift 10 nearby crops as this product will caUSe mooilications in plant growth. Plant iniu"/. dr re21ucod yiolGis wiD resull. 

•••• 

00 not plant another crop within 30 days after treatmont. 

Mix only Urn amount of spray you oxpect to use aach day. Do not allow mixod solution to stand ovornight 

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165 
" 

DIRECTIONS FOR USE 

It 18 • violation ot Fedoral Law to use this product In a manner Inconalatant with Its labeling. 

Road entlr. labo' bafor. usIng thIs product. 

REENTRY STATEMENT 

Mixers, loaders and applicators must woar a fuH face shield, long trou$Ors, long sloevud shirt, glovos and ~ots to avoid as much skin 

and eye contact as possible. 

00 not enter tmmGd fiGlds within 24 hours after application unless protoctive clothing is worn. 

1~!~~~"'~~n~laminat. water, food, or food by storage or disposal 

containor is brokon oreontanls have spilled, lolk>w aU precautions indlcatod abovo and clean up immediately. Before cleaning up, 

fuU length trousers, long slhvod shirt. protective gloves. and goggles or face shield. Soak up spill with absorbent media such 

sand, earth or other suitable material and dispose 01 wast. at an approved wast. disposal facility. 

'~:;.~~:~~II~;, DISPOSAL I! wastes are acutely hazaIdous. Improper disposal 01 excess pesticide, spray m!xturo. or rinsate is a violation 01 Fodorallaw. 

those wastes cannot be disposed of by use acoording to label instructions, contact your Stahl Pesticide or Environmontal Control 

I ~~~~,~~th:~e Hazardous Waste reprosentative at th8 nearest EPA Regional Office lor guidance. 

L DISPOSAL 

tho ampty containers. Thon ollor lor Ii 01 in a sanitary 

i i 

GENERAL INFORMATION 

COTTON 

A foliar spray of PREP~ brand Ethophon will acotIarate opGning of mature unopened cotton bolls and enhanco dalol;ation which can result in oatNar harvGst with an increased r&coverable yiold. PREpTW brand Ethophon troalment on cotton allows increased efficiency 

lrom-a once-over harvest. 

TOBACCO {FLUE.CURED): A loliar spcay 01 PAEpnc brand Ethephon promotes early, uniform "yellowing~ 01 mature tobacco. 

PREpnc reduces curing time, allowing mora officiant usa 01 curing barn space, and increased control over harvost schedules. 

SPRAY PREPARATION 

Add 11210 3/4 of tho required amount of Waler to the spray tank. Start agitation, Add tho required amount 01 PREPno brand Ethophon, 

and the remaining amount of wator, Prepare only as much spray solution as can be uSGd on tho day of mixing. Do not allow splay 

solution to stand overnight. 00 not spiU tho concontratod product on spray equipm~nt, or any airplane parts. 

ANY SPILlS SHOULD BE RINSED IMMEDIATELY WITH PLENTY OF WATER 

Use 01 a nurse tank is highly recommondod for avoiding possible spilla of concentrated fOfmulation on spray oquipmant or any airplane 

parts • 

• 

COMPATIBILITY . 

PREP'"' brand Ethophon is compatible with DEFt, FOLEX'*, Draw. Harvoo03, Mathy! Parathion, Guthion1, and Malathion', and may be 

appfiod in SGqUGtlCO or as a tank mbctute (DO NOT TANK MIX Willi DESICCANTS F COTTON IS TO BE SPINDLE HARVESTED). In 

some casos slight reduction in boll opening responae has boon observed when lank mixos with dololiants wine used. 

Good agitation in tho sPfay tank is ouontiat and a tank mixture should not be allowed to sland without agitation for more than 5 to 10 

minutos. Read and observo all appropriate tabol usa dirOdions and precautions lor the defoliants and insecticides used. 

NOTE: Under cartain conditions, tank mixtures 01 PREpnt brand Ethophon with d05iocants containing sodiUm chlorate oould 

rasult in the formation ot hypochlorous acids which on heating will omit toxic chloride lumes. 

EQUIPMENT CLEANING 

BDCtIuse 01 the acidic natura ot this product. prolonged oxposure to spray doposit will damage acrylic plastics. CfLtfWo:Q4ints. and 

metals, • 

Rim. thoroughly with a detergent and wOller all exposod acrylic plaslic·typo matorials (o.g., aircraft windshiolds).I:M1::wtlntod surfacos 

wfthln an hour altar exposure to spray deposits. : •• :.: •••• 

At tho end of each day, rinse thoroughly with a dotergent and watar aU the motal parts of tho aifcra~ and the asSociated spray 

oquipment oxposed to tho spray deposits. •••••• :... • •• ••• • .. • 

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166 
COTTON 

EXPECTED PREp1loI ONE SPRAY VOLUME APPLICATION 

USE CONDITIONS RATE GALLON (Gala/A) TIMING 

PREPO( 

LOS A.1. Acr .. Air·· 

PREpm Hot and dry 8O"'F Of 1113 1.0 6 Apply when the numbor ?f 

Boll Oponer" higher mature unopened bolls,. is 

Dry and 75 to IWF 2 1.5 • 15 ·50 2·5 sufficient to P~d=~~~~ desired crop. SIIG 

Cool but above SS-F 2213 2.0 3 test of boll ~'!. 

2213 

Treatment ~~oris 

Rank cotton 2.0 3 bolls 7 to . 

PREpni + High so~ moisture 113 0.25 2. 15 ·50 5 -10 Apply 4 to 7 days Pfjo~ to 

FOLEX" High fertility level PAEpnl boll opening 

Defoliant rank Rank cotIon ."",leallco. To bo US~,5 

Mix a- treatment 

001 in plac. of PRE,,", 

PREpnf+ Droppz High $Oil moj!llur9 113 0.25 2' 10 - 50 3·10 Apply'" to 7 days prio~ to 

Oofollant Tank High fortility lavol PAEpnI boll j 

Mix Rank cotton application. To be UUd.~s 

eo SO~U:I=lr8atm8n~w:i not in of PAEPTM 

Pre-Conditioner Hot, dry, 213 0.5 12 Apply 4 to 7 days prior. to 

for DefOliation Cool, above 65°F 1113 1.0 6 15 ·50 2·5 delolian!. Enhances top 

crop defoliation reducing Rank collon 1113 1.0 6 dolorioration of bot1om~~,r~ and allows for I 

·Pretreatment With Defoliants Prior to PREptloI Boll Opening Treatment 

If tho cotton is overly rank or laying down m tho middt.. and good spray coverage of tho bolls with PAEptw is difficult, a pretreatment 

with defoliants wi. be usaful to improve boll covarage with PAEpm. Use dosage talos of PREP'"" brand Ethophon Cotton BoU Oponer 

tOCOmmondGd for boll opening. Road and observe all appropriate iabol use directions and PfOCQutlons for tho defoliant used. 

·-In California and Arizona use a volume 01 no loss than 5 gallons poT acre for aerial applications. 

Boll Maturity 

• 

A boB is mature when it is too hard to be donted when squoezed between thumb and lingOTS, too hrud to be sliood with a sharp knife, and 

when the seod coat becomes light brown in color. 

Use LlmbatioRs 

• Do not oxeo&d a maximum of 2.0 Ib, aiJA for combined uses 01 PAEPN per acro por year. 

BoU Opening: 00 not tank mix PREpllI brand Ethophon with a desiccant if tho cotton is to ba spindte harvested, 

Pre·Condition for Defoliation; Do not tank mix PREPnI with desiccants unloss plant dosiccation Is required, 00 not use a defoliant 

bafore thore is sufficient maturo unopened boils to produce tho desired yiekl {seo Genera! Inlormation section on how to tost for bol! 

maturity. 

WHEN TO HARVEST COTTON • • • ••••• Do not harvest cotton sooner than 7 days after a treatment with PAEpnt brand Ethephon Cotton Boll Opener. • 

Observe the treated crop and harvost whon optimum bol! oPfining has boon reached. Too earty harvest might roIilM.t!liG lull advantage 

01 the troatmont and too late a harvest may result in roduct.ld quality and loss of lint which wijl drop ftdlfl)no plant···· 

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167 
PREpTW 

Crop Situation Plnt./Acr. 

Otroct&d Spray 

Application 

Over-Tho-Top 

Application 

11/3 

11/3-22/3 

USE LIMITATIONS 

40-60 

TOBACCO 

(Flue-Cured Only) 

Spoclftc DIrections 

U&o drop rtOnJo.. Choo" TG or DC spray tips designtrl to apply 50 

3540 psi and at tractor speed of 2~3 mph. 

I ~nazzh".I>.., on to each be side ripened of the and row harvosted dropped ~::j~:~~~J!~:: . I • dirocted spray, be sur. 10 harvest 

only when leaves remaining on tho stalk aro maturo. To 

romaining loaves are mature, tost spray several tobacco plants 

d9SClibed under the section ·Proper 11m. of Treatment- Usa tho lower 

in a normally mature crop when experience indicates that minimum I 

inducament Is required. Usa1ho higher rate whon tho crop is heavy and has 

a tendency to be more rank or when temperatures are lower than normal. 

Always last spray to determine if the tobacco is mature enough to respond 

10 treatment with PREprw brand Ethephon. 

Apply over-tho-top PREpni brand Ethephon spray as a 1ino mist 

nozzles (ono nozzle tips over the cootor of the plant, and 

$0 aJl leavos are covered similar to the I 

00 not apply PREpn.f bnlnd Ethephor:!o immature loa .... 5 as this can result in unsatisfactory coloring, weight loss and redUCiKlloat 

quality. " 

00 oot allow the crop to over ripon in the field after using PREP'"" brand Ethephon. since this may cause somo roduction In yiGld and 

quality. 

Do not treat before anticipatGd mapr storm which could prevent harvest and result in crop loss. 

00 not apply PREpDI brand Ethophon if rain is expoc1od within 4 hours. 

APPLICATION TIMING 

SUCC8Ssful results with PREPN call for treatment when loaves are malure, not overly rank green whon sprayed. To easUy determine 

Ihe propor uoalmont liming and tho numbor of leaves por stalk ready 10r harvost, test spray several plants In mora than one klcation in 

each flGld and oburvetho rlMponso. Maturo !envos will begin to yellow in 24 to 72 hours. Tost!eavos that fail to yellow In 72 hours Me 

not matura and are not ready for PREpTW brand Ethephon troatmon\. Walt a fow days to pGrmlt further natural maturing, then mako 

another test spray or -maturity- check. 

When you have conflrmod the numbor of leaves per plant that will color, you can detarmine tho numbo! 01 acros to traal in order to fill 

Ihe bam. 

_ Proparo your test spray by mixing one teaspoons of PREpf>o! in 1 qUM of w~tor. Spray each tost plant with about 1 oz. of this mixlure, 

covering aU loaves with a line mist. PREPtl<! brand Ethephon will not color immature sprayed laaves. 

WHEN TO HARVEST 

All maturo, sprayed loaves wUl beg!n to color within 2410 72 hours aftor PREpTloI brand Ethep/lon application. The yollowing procoss is 

weathor dependent; cool weather wiU delay, while hot. sunny woather can spGed up the process. Harvesttreatod lobacco whenleavos 

have reached the dO$lroo color Inlensity. 

Do not allow tobacco to b&oome over ripe before starting harvost. loaf drop can occur when tobacco is ovor ripe and left on the stalk.. 

M a number of tho bottom loaves have yellowed at tho timo ot treatment, 1hoy should bo harvested prior to spraying with PREpTW brand 

Elhephon. • • 

••••• • With an ovor·the-top application, harvesting can commence 24 hours after PREpm brand Ethephon application depending on weathor 

condilions or to avoid ovor ripe tobaa:o. Tobacco harvosted 24 hours after trea1ment will roquire moro time in tho nloJirlg phase 01 tho . . . curltlg procoss. •••••• • ••• 

• •• CURING PREp1\I TREATED TOBACCO : .: • 

Curing ptoooduros are as much an art as a science and oach cure must be judgod on tho basis of ~ condJltvl, "q,terval betwGen 

Ireatment and harvest, we.thor and typo of ctJring facility boforo proscription tomporature an; VGf.Itlfati<fn adtodulos can be 

estabUshod. To obtain maximum quality, care must be taken to obselVo and contmltho curing proceoooCJoSOlytfleefa/1y during tho 

late -coloring- and aarly -drying- stages of the loaf. ••••• .: 

• • PREpn. brand Elhephon treated tobacco wiU have startoo tho coloring process whon harvestad, reduckJ.the time rtK(Ulrod In 1ho 

coloring phase of curing. Trealed tobacco should be dried faster. If toblKXX) leaves are green oroontain same grtoQWflon harvoslod, 

it may be necossary10 color them for a few hours. If the leaves are completely yellow, temperature and ventHation~a8t be adjusled in 

a mannor to dry tho tobacco as fast as possiblo without scalding. Onoa tho loaf Is dried (314 dry), you should followonormal procedures 

for coring. SitlCG PREpnI brand Ethaphon treated leaves cure lastor, treated and unlreated Ioavos should not bo~~" regather in the 

S!l:t10 barn. 

168 
LIMITED WARRANTY AND DISCLAIMER 

:;... manufacturer warrants fa> th~t this product cooforms to tho chomal d&&cription on the 1aI»I; (b) thallhis product 1$ reasonably fit 

for tho purposes sot forth In tho dfr8CIions for usa when it Is used In accordance with such directions; and (e) thai tho directions, 

warning and other slatements on fhls label ate based upon reoponsiblo oxperts' evaluation of roasonable fosls of ettectiV8noss. of 

toxicity fa laboratory animals and to plants. and of rosidua. on food crops and upon reports of field experience. Teals have not boon 

mado on all variatio; or In aU states or under aU conditions. THE MANUFACTURER NErrnER MAKES NOR INTENDS. NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES. EXPRESS OR IMPLIED, ANO IT 

EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPUED WARRANTIES OF MERCHANT·ABILITY OR FITNESS FOR A PART1CULAR 

PURPOSE. 

nilS WARRANTY DOES NOT EXTEND TO. AND lHE BUYER SHAU BE SOLelY RESPONSIBLE FOR, ANY AND ALl lOSS OR 

DAMAGE WHICH RESULTS FROM THE USE OF THIS PRCOUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE LABEL 

DIRECTIONS, WARNINGS OR CAUTIONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY ANO ALL CLAIMS, 

LOSSES, DAMAGES, OR INJURIES RESULTING FROM THE USE OR HANOUNGOFTHIS PROOUCT, WHETHER OR NOT BASED IN 

CONTRACT, NEGLIGENCE. STRICT LIABILITY IN TORT OR OTHERWISE SHALL BE LIMITED. AT THE MANUFACTURER'S OPTION, 

m REPLACEMENT OF, OR THE REPAYMENT OF THE PURCHASE PRICE FOR, THE QUANTlTY OF PROOUCT WITH RESPECTm 

WHICH DAMAGES ARE ClAIMED. IN NO EVENT SHAll MANUFACTURER OR SEllER BE LIABLE FOR SPECIAL. INDIRECT OR 

CONSEOUENTlAl DAMAGES RESUl TlNG FROM 1HE USE OR HANDlING OF nilS PRODUCT. 

NOTICE TO BUYER 

Purchase of this product does not confer any rights undor pationts governing this product or tho use Ihereol in countries oUlsido of tho 

United Stat8S • 

• 

IDEF and Gulhion are registored tradomarks of Bayor AG, Germany. 

20ropp is a registered Irad.marie:: of NOR-AM ChomK:al Company. 

3Harvado is a registered trademark of UniroyaJ Company. 

• 

4MaJathion is a trademark of Amorican Cyanamid Company . 

Rh6no-Poulonc Ag Company 

P.O. Box 12014,2 T.W • .Nexander Drive 

RosNl'Ch Triangle Park, North Carolina 2n09 

PREP is tho trademark 01 Rh6ne·Poulencior Elhophon Cotton Boll CponOf' 

FOlEX is a regislorad trademark of RMno-PoulGnc. 

PREpn! brand Ethophon for Cotton and Tol::lacco (PENDING) Submitted 10123192. 

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169 
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• 

DATE: / /- k - 2). 

TO: FILE ROOM 

DOCUM.ENT CENTER 

PRODUCT MANAGER 

PAM (ROOM 263) 

TXfE Qf REG!STRATION 

PAST - TRACK ACTION 

This action has been determined to be a fast-tracK action 

by FEPS and ~ be entered in the PRATS using one of the 

following codes: 

160 - Application for "me-toll registration 

170 - Application for registration - old chemical - "Metoolf with additional use. 

300 - Amendment - label revision - administrative (no 

data required). 

305 - Amendment - label reVlSlon - data required does not 

need HED/EFED review. 

J 10 - Amendment - added "me-too" Use - no HED/EFEO review 

needed • 

345 - Formula change - no HED/EYED review required. 

REGULAR REGISTRATION (with data/without data) 

24C NEW 

R%8UDHIBSION Cr •• pan •• to Aqancy ltr) 

PlHAL'PRINTED LABBLS 

OTlDlR 

KESBAOI' __________________________________________________ __ 

170 
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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON,O.C. 20460 

MARGARET CHERNY 

RHQNE-POULENC AG-COMPANY 

P.O. BOX 12014 

10/30/92 

RESEARCH TRIANGLE PARK NC 27709 

Product Name: PREP BRAND ETHEPHON FOR COTTON 

Company Name: RHQNE-POULENC AG COMPANY 

Application No.: 153345 

EPA Reg. No.! 264-418 

EPA Receipt Date: 10/28/92 

Subject: Front End Screen for an Amendment 

Dear Sir or Madam: 

OFFtCEOf 

PESTICIDES ANOTOXIC 

sUasTANCCS 

Your application for registration has been received by the 

Office of Pesticide Programs and has passed a preliminary screen 

for completeness. It will be placed in line for review to 

determine its acceptability. The- application will be processed 

in chronological order of receipt. 

Although the 1988 FIFRA amendments mandate EPA to review 

applications for expedited registration or amendments within 90 

days I this turnaround time will not be met immediately due to the 

backlog of applications received before December 24, 1988. 

However, EPA is increasing human and automated resources and 

making necessary procedural changes in order to eliminate the 

backlog and to meet the 90-day response time as s~on as possible. 

If you have any questions, you may contact C. Giles-parker, 

Product Manager 22, at (703)-305-5540. 

Sincerely, 

~.uJ~ 

Team Leader 

Front End Processing staff 

Registration Support Branch 

Registration Division (H7504C) 

@ Printed on Recycled Phper 

171 
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• 

Mr. Warren A. Davis 

Rhone-Poulenc Ag company 

P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle park, He 27709 

Dear Mr. Davis: 

Subject: Revised Labeling 

PREP Ethephon cotton Boll Opener 

EPA Registration No. 264-418 

Your Submission Dated June 30, 1992 

The amendment referred to above, submitted in connection with 

registration under the Federal Insecticide, Fungicide and 

Rodenticide Act (FIFRA), as amended is acceptable provided that 

you: 

1. Make the labeling changes listed below before you release 

the product for shipment bearing the amended labeling: 

you 

Modify the Environmental Hazards Statement to include the 

following statement: 

Do not apply directly to water, to areas where surface 

water is present or to intertidal areas below the mean 

high water mark. 

2. Submit one (1) copy of your final printed labeling before 

release the product for shipment. 

A stamped copy of the labeling is enclosed for your records. 

Sincerely yours, 

/~ ~/ 

/ 

Cynthia Giles-Parker 

Product Manger (22) 

Fungicide Herbicide Branch 

Registration Division (H7505C) 

Enclosure 

172 
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PRE P TM BRAND ETHEPHON COTTON BOLL OPENER 

INE:RT INGREDIENTS: ........................................................................................................................... .44.6% 

KEEP OUT OF REACH OF CHILDREN 

DANGER PELIGRO 

PRECAuctoN At USUlJUO: SI ustod no 100 ingles, no use osto producto hUla quo Ia informacion on 1& e1ique1a. Ie haya sido oxplicado 

Th. usa of this product for a variety 01 plant growth regulation U50. is covorod by Unitod Statas and foreign patents including 

U.S. Patents3.879,188 and 4,240,819. No Ilconse is grantad 10 use this product in counlrios olhor than tho United States or lor any 

us. not conlomplateci by this label. Liability for patont infringement may r85uh from use or sal. of this product outside tho United - S1ales . 

STATEMENT OF PRACTICAL TREATMENT 

IF IN EYES: Hold oyelkls open and flush with a genlla stream 01 wafer lor at loast 15 minutes. G01 medical attention, prelorahly an 

ophthalmologist. 

IF ON SKIN: Immediately wash skin with plenty of soap and waler. Romovo contaminated clothing and shoes. Wash clothing 

separately bolore rouse . 

• IF SWALLOWED: Do not induce vomijing. Prompdy drink a large quantity 01 milk. tI99 whiles, gelatin sotution or ~ those aro not 

lfIalJablo, drink large quantijies 01 water. Avoid alcohol. Call a physician immediately. 

IF INHALED: Remove victim to Iresh air. "not breathing. give artificial respiration. Administer o:tygen il necessary. Get medical 

attention. 

PRECAUTIONARY STATEMENTS 

DANGER 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

CORROSIVE. Causes eye and skin damago. May bo latal ~ absortxtd through skin. Harmful if swallowed or inhaled. Avoid 

breathing spray mist. 00 not got in eyes. on skin or on clothing. Woar luilleogth trousers, long slooved shirt, prOtectivo 91ovO$, and 

goggles or faca shield whon handUng. Chango to clGan wOlk clothes daily. Wash thoroughly with soap and water aftor handling and 

before oating, or smoking. Romovo and wash rontaminatoo clothing bolore reuso. Koep away Irom domestic animals. 

NOTE TO PHYSICIAN 

Thoro is no spocific antidote. Alltr.atmont should bo based on observed signs and symptoms 01 distroS$ in the patient. Overexposure 

to materials othor than thll. product may have occurred. 

Victims 01 saveret overexposure, by inhalation, should bo kept undor medical oil&olVation lor up to 72 hours lor dolayod onset 01 

pulmonary edema. In a victim 01 ovorexposuro by ingostion, careful gastric 18'\1age is lequired due to th. possibility 01 stomach or 

esophagoal porteration. This mat.rial is an acid. but use 01 alkalino substances to neutralize it is ronlraindicated. 

ENVIRONMENTAL HAZARDS ••• • Do not apply directly to water or wetlands (swamps, bogs, marshes, and potholos). 

equipment wsshwa1ers. 

Do not c:w;r;runato wate' Allen disposing 01 

00 not contaminate wator usod lor irrigalion or damoslic purposes. 

USE PRECAUTIONS 

• • • 

• • • • • 

• ••••• 

• • • • •• 

• 

••• • •• Do not apply PRE?n' brand Ethephon Cotton Boll Opener through any typo of Irrlgalion systam. ..:... •• • 

Avoid spray drift 10 n04lby crops as this product will causa modifICations in plant growth. Plant infuf1e, ;oducod yiOlds wiU result. 

• •• 

Do not pfant another crop within 30 days aftar treatment. •• : ••• 

Mix only the amount of spray you 8Xpoc1tO uso oach day. Do not allow mixed solution 10 stand overnight. •• • •• • 

• •• 

173 
DIRECTIONS FOR USE 

It Is a violation of Fodoral Law to use this product In a mann or Inconsistent with Its labollng. 

Road entlro fabel boloro using this product. 

REENTRY STATEMENT 

Mixors, loadors and appficators must wear a full faco shiok:!, long trousors, long SIQ9v(Ki shirt, glov9s and boots 10 avoid as much skin 

and eyo contact as possiblo. 

Do not onlor troated fiolds within 24 hours after appli<:alion unloss proloctivo clothing is worn. 

::;luRAGE 

STORAGE 

00 not conlaminalo water, food, or toad by storago or disposaL 

II containor is broken or contents have spilled, follow all precautions indicated above and clean up immodiately. 6010ro cloaning up, 

put on fun length trousers, long sleeved shirt, protective gloves, and gogglos or face shield. Soak up spill with absorbent media such 

as sand, earth or other suitable material and dispose 01 waste at an approved waste disposal lacility. 

PESTICIDE DISPOSAL 

Pesticide wastes are acutely hazatdous. Impropor disposal 01 excess pes1idde, sptay mixture, or rinsate is a violation of Federal law. 

I! these wastas cannot be disposed 01 by use according to label Instructions. contact your State Pesticide or Environmenlal Control 

Agoncy or the Hazardous Waste representative at Ihe nearest EPA Regional Office lor guidance. 

CONTAfNER DISPOSAL 

• 

Triple rinse (or equivalent) the empty containers. Then offer lor re~ycling or reconditioning, or puncture and dispose 01 in a sanitary 

landlltl. or by' incineration or if altowGd by stato and local aUlhorities, ov bUrnina. If container is burnod. stayout 01 smoke. 

• 

GENERAL INFORMATION 

A follar spray of PREpN brand Ethophon Collon Bolt Opener win accelorate opening 01 malUro unopened cotton bolls and anhance 

defoliation which can rosult in oarlier harvost with an incre8s;ed recoverable yield. PREpn.! brand Ethephon Cotton Bolf Opener 

• treatment allows increased efficiency from a onCG-ovor harvest. Some premalure drop ot small, immaturo bolls may be associated wllh 

t!eatme-nt. Do not apply before sufficient, maturo, unopened bolls have devalopad to produce the desired yield of cotton. 

A bon is malUtO when it is too hard to be dented when SQueezed betweon thumb and fingers. too hard to be sliced with a sharp knifo. and t! 

when tho saod coat bocomes light brown in color. 

For bast nisu~s. thorough and unitorm spray covorage is required. It is essential that tho bons are contacted by tho spray to obtain 

optImum boll opening. Obsorvo treated fields closely. Harvest at optimum boll openIng and defOliation. genorally 14 to 21 days atter 

treatment. Sustained cool watlther with average day and night temparatures of SS'F or lower after treatment with PREprn brand 

Elhephon Colton Boll Openor will delay tho bolt opening rOllponse. 

Do not apply PREpnI brand Ethophon Cotton Boll Opener if rain is oxpocted within 6 10 8 hours. Rainlalt within 6 to a hOUrs of 

application may reduce product poriormance. 

Cortifiod cotton seed growers should observo boll and sood maturity bel ore Ireatment with PREpllol brand Ethophon Conon Boll Opener. 

Bons not completoly mature might open with treatment 01 PREpn.t brand Ethephon Cotlon Boll Opener giving lower quamy seed . 

Spray deposits of PREpTM brand Ethephon Col1on Bolt Openor, when loft on aIrcraft acrylic plastic type windshields for longer than t 

hour, may react with this material. forming an opaqw\I film or spots on the surface which cannot be removed by washing wilh water or 

any other cteaML Rinse windshields with water immediately after each lankload of PREp":'!>!. brand Ethephon Colton Boll Opener has 

boon applied. Thoroughly rinso tho aircralt with cloan water alter oach day PREPrn brand Ethophon Cotton Boll Opener is applied. 

PREprn brand Ethophon Cotton Bot! Opener may also allect co~ain paints, and if accidenlal deposits on paintod obiects such as cars. 

trucks, agricultural equipment. etc. occurs, those objects should be rinsed with water as soon as possible (within 1 hOUr) to prevent 

permanent staining of the painted surface. 

SPRAY PREPARATION 

Add 1/2 to 3/4 01 the required amount 01 water to Ihe spray tank. Start agitation. Add tho roquired amount 01 pREprn brand Ethephon 

Colton Boll Opener, and the remaining amount 01 water. Proparo only as much spray solution as can be used onot+lo day of mixing. 00 

not aUow spray solution to stand overnight. Do not spilt tho concontrated product on spray equipl'Tl()(\f.*Gl'.any airplah. ~arts. 

• •• ANY SPILLS SHOULD BE RINSED IMMEDIATELY WITH PLENTY OF WATER. : .: • 

Use of a nurse tank is highly recommended lor aVOiding possible spills of concentrated lormulatic"~~ay equipmant or any 8irp!ana • • "~ . . .. .. . EQUIPMENT CLEANING • •• •• ••• • •• • • Because of Iho acidic nature of this product, prolongnd exposure to spray deposit will damag~nD'Jic plastics.acertain paints, and 

metals. . • •• , . Rinso thoroughly with a detergent and water alt oxposed acrylic plastic·type materials (e.g .. aircralt windshioldsj,~M paintQd $uriacos 

within an hour alter exposure to spray deposits. : •••• 

At the end of each day. rinse thoroughly with a detergQnt and water all the metat pariS of tho <lircratt and thct associatod spray 

equipment oxposed to the spray deposits. 

174 
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• 

j 

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.-.. _. -----------------

PRETREATMENT WITH DEFOLIANTS PRIOR TO PREP~ PLANT REGULATOR 

If the cotton is ovorly rank or laying down in tho middlos and good spray covorago of tho bolls with PREpno is difficuk, a pretraalmont 

with dofoliants will be usofur to improve boll covorage with PREPJ'I.I. Usc dosage ratas of PREPn; Plant Regulator rocommondod for beR 

opening. Road and observe al! appropriate labor use directions and precautions for tho defoliant used. 

Do not oxcGGd a maximum of 2.0 !b aVA for tho combinG<.! use as a proconditioning treatment for dofoliation and cotton boll opening, 

00 not use a dofoliant boforo ther~ are sufficient mature unoponod balfs 10 produCG tho desirod yio!d {SOQ Genoral Information sQction 

on How to Tost for Boll Maturily}. 

BOLL OPENING 

Spray Volume 

Rato rGarslA! 

Condltfons expectod t Gallon Application 

5-7 days aftar tr.atment prnts/A LBS A.r. Treats Ground Ar, Timing 

Hot and dry 80" F or higher t-113 1.0 6 Acres t5-50 2-5 ~ Apply when the number 

Dry and 75 to 800 F 2 1.5 4 Acres or mature unopened 

bolls is sufficient to 

Cool bul higher Ihan 65" F 2·213 2.0 3 Acres produce tho desired 

Rank cotton 2-2/3 2.0 3 Acres 25-50 .... yield. 

RESTRICTIONS: Boll Opening 

• In California and Arizona use a volume ot no less than 5 gallons por acre for aerial applicalions . 

PRECONDITIONING FOR DEFOLIATION 

Spray Volume 

Rato (GaISIA) 

Conditions expeclod , Gallon Applfcatlon 

5·7 days aftor troatmant PlntslA LBS A.!. Traats Ground Ar, Timing 

Act and dry 80· F or hlgher 213 0.5 12 Acres 15-50 2_5d" Apply 4 to 7 days prior 

Cool but higher than 65° F 1-tl3 1.0 6 Acras deloliant application or 

tank mix with the 

Rank col\on t- tl3 1.0 6 Acres defoliant application 

(soe Compatibility 

soction). Do not lank 

mix with dosiccanls 

unloss desiccation I, 

reQuired . 

. :tESTRICTlON5: Pracondltlonlng for Defoliation 

• In Calilornia and Arizona use a volume 01 no less than 5 gallons par acre lor aerial applications. 

• Do nOI exceed a maXI-mum ot21b ai/A lor lhe combined use as a preconditioning treatment lor dafolialion and colton boll opening, 

• Do not use a defolianl before there arG sufficiant maluro unopenod bolls to produco Iho dosired yfold (sso GGnoral Inlormallon). 

COMPATIBILITY 

PREpm brand Ethephon Colton Boll Openor is compatible w~h DEF'. FOLEX~, DROPp2, HARVADE3. METHYL PARATHION. 

GUTHIONT AND MALATHION'1, and may be applied in sequence or as a tank mixture (00 NOT TANK MIX WITH DESICCANTS IF 

cOnON IS TO BE SPINDLE HARVESTED). In some cases slight reduction in boU opening rosponsa has baan observed when lank 

mixes with defoliants were used. 

Good agitation in the spray tank is Gssential and a tank mi:dure should not be: aHowed to stand withoul agitation for mora than 5 to to 

minules. Read and obsGlVe all appropriate label use directions and precautions for the deloliants and Insecticldvl1~s~. 

PRECAUTION : •• :-: _. 

. .. - Do not tank mix PREPTM brand Ethophon Cotton Boll Opener with defollan~ co"talnlng sodium chlorate 

because this relulls In Ihe formation of hypochlorous acids which upon heatlng·.mit toxic chlorine fUmes. 

WHEN TO HARVEST • •• • • •• 

Do not harvest cotton sooner Ihan 7 days alter a troatment Wilh PREPw brand Ethephon Cotton B'il1,l~nor. • ..... 

Observe tho trealed crop and harvest when optimum boll opening has been reached. Too early h'1l¥ht might reduce the full advanlage 

01 tho troatmont and too lata n harvesl may result in roducod quality and loss 01 lint which will drop from ihe plant . •••• 

•••• 

. , • • . • •• 

175 
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LIMITED WARRANTY AND DISCLAIMER 

Tho manuillcluror warrants (althal this product conforms to tho chemical description on tho label; (b)lhat 1his product is reasonably iii 

lor tho purposes set forth in tho dilOCllons for use whon it is used in accordance with such directions; and ee) thai the directions, 

waming and other statements on thlslabol aro based upon responsiblo exports' evaluation 01 reasonable les1s of onl)(:tivoness, of 

toxic~y to laboratory animals llnd to plants, and of residues on food crops and upon reports 01 field experienco. Tosts have not boon 

made on aD varieties or in all states or undor all conditions. THE MANUFACTURER NEITHER MAKES NOR INTENDS. NOR DOES IT 

AUTHORIZE ANY AGENT OR REPRESENTATIVE TO MAKE. ANY OTHER WARRANTIES. EXPRESS OR IMPLIED, AND IT 

EXPRESSLY EXCLUDES AND DISCLAIMS ALL IMPLIED WARRANTIES OF MERCHANT-ABILITY OR FITNESS FOR A PARTICULAA 

PURPOSE. 

THIS WARRANTY DOES NOT EXTEND TO, AND THE BuYER SHALL BE SOLELY RESPONSIBLE FOR, ANY AND ALL LOSS OR 

DAMAGE WHfCH RESULTS FROM THE USE OF THIS PRODUCT IN ANY MANNER WHICH IS INCONSISTENT WITH THE LABEL 

DIRECTIONS, WARNINGS OR CAUTIONS. 

BUYER'S EXCLUSIVE REMEDY AND MANUFACTURER'S OR SELLER'S EXCLUSIVE LIABILITY FOR ANY AND ALL CLAIMS, 

LOSSES, DAMAGES. OR INJURIES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT, WHETHER OR NOT BASED IN 

CONTRACT, NEGLIGENCE, STRICT LIABILITY IN TORT OR OTHERWISE SHALL BE LIMITED, AT THE MANUFACTURER'S OPTION, 

TO REPLACEMENT OF. OR THE REPAYMENT OF THE PURCHASE PRICE FOR, THE QUANTlTY OF PRODUCT WITH RESPECT TO 

WHICH DAMAGES ARE CLAIMED. IN NO EVENT SHALL MANUFACTURER OR SELLER BE LIABLE FOR SPECIAL, INDIRECT OR 

CONSEQUENTIAL DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT. 

NOTICE TO BUYER 

Purchaso 01 this product does not conlcr any rights undor patients governing this product or the use therenl in countries outsido 01 the 

Unllod States. 

The use of this produCllor a varioty 01 plant growth regulation uses is protected by various United States and loroign patents including 

U.S. Palents 3,879,188 and 4,240,819, No license is granted to usa this product in countries other than tho Unilad Slates or for any 

usa nol contemplated by this labal. liability for patent intringament may result from usa or sale 01 this product outside the United 

States. 

t DEF and Guthian ore registered trademarks ot 8ayor AG, Germany . 

• :: Dropp is a registered tradamark 01 NOR-AM Chamical Company. 

3 Harvade is a ragistered trademark 01 Uniroyal Company. 

4 Malathion is a tradGmark 01 American Cyanamid Company. 

) 

\ \ 

RhOno·Povlol'lC Ag Company 

P.O. Box 12014, 2T.W. Aloxander Drive 

Resoarch Triang!9 Park, North Carolina 27709 

PREPlu is a trademark 01 RhOna·Poulonc, 

Folext is a registored trademark 01 Rh6ne-Povlenc . 

ACCEPIED 

_COMMENTS 

In EPA Lett" Dat«l, 

rJ:'d~,,- lhe )'i·Jcml In:-,ectiode 

:·'.".l~' ;:{ooenti.cide Au "~". ",,'''''1 I', .k .• ~-~;....<,~'" '".~_"."c~, '.1 Uf<;: J~""'-

",,>d Ilnilfr EPA Reg.m 

,;/4' '/- If II? '] 

PREPTI-! brand Ethophon Collon Boll Opaner (Pending) Submitted -,_191. 

•••••• • •• • •• 

• • 

•••••• 

• • • • •• 

••••• • • • • •• ••• 

••• • 

• • •• 

• 

••• • •• ••• 

• 

• •• •• • •••• 

•• • •• • • •• 

176 
r-----~'---

• 

'" '''-

RH6NE~POULENC AG COMPANY 

ETH·92·11 

June 30. 1992 

U. S. Environmental Protection Agency 

Office of Pes!icide ProgramsJDocument Processing Desk 

Room 266 A. Crystal Mall No.2 

1921 Jelferson Davis Highway 

Arlington, Virginia 22202 

Attention: Cyn1h!a G!!es~Parker 

Product Manager (22) 

Fungicide Herbicide Branch 

Registration Division (H7505C) 

"-'-'" -

e Dear Mrs. Parker: 

• 

E!hrel® brand Plant Regulalor for Pineapples and Sugarcane 

EPA Reg No 264·257 

Ethrel® brand Plant Regula!or 

EPA Reg. No. 264·267 

Cerone® brand Plant Regu!alor 

EPA Reg. No 264·377 

Prep® for Cotton brand Plant Regulator 

EPA Reg •. No 264·418 

The appended label amendments lor ethephon containing products include a general format 

change with use directions now presented in tabular form. The amendmenls are intended 10 

simplify proper use directions and consolidate information in one section 01 the label. In 

addition a patent stalement has been added 10 the front panel of each label. This statemenl is now 

unilormly included on all ethephon produc!s. Cer1ain other editorial changes have been made 

thai are consislent wilh the last EPA approved label. For instance certain volume, rate and 

!realment liming ranges have been modilied !o recommend only one value ins!ead of a range. 

To complete our submission we are including an application for amended registration and 5 

copies of each label. We would appreciate one stamped approved label relurned for our tiles to 

facilitate state registrations and avoid any enforcement queslions. 

Thank you for your assistance in this registralion acllon. If you have any queslions please fee! 

tree to contact me promplly. (919-549-2379) 

Sincerely. _ 

-a/r2~/4:'l\< }\ 

Warren A. Davis 

Senior Registration Manager 

•••••• 

• •• 

• •• 

• • 

•••••• 

• • 

• • 

•• 

••••• 

• • 

• • ••••• 

••• • 

•• •• 

• 

• •• 

• •• 

•• • 

• •• 

•• • •••• 

PCi30,_';(iH 2'NALE.I::',LL'£" :"«'C 

nGEfopC'lTnYI<';v:roMW '~,: :';:i" 

'9'91 ~,,19 ;,)JC 

.. . •• • 

• •• 

,qT[ANA1.(,hAllilIJhU/';"! _,\'!.,i,c;'i--'J.,,-' 'Ill' 

I'" ~I;Wt!·11("4i'\L t:i'7"<!;,C," c; ", ~, ~i i '. , '", '.'''''-" ",<,in: ?i' ',\, .y - "~' " 

177 
, . on MIfMllfI . nv." 

(A) & EPA 

UniWd Status Environmental PrOlOCtion Agoncy Registration loPP loonllilcr NlImbm 

Offioo of Pesticide Programs (H7505C) 

~ Washinglon, DC 20400 Amendment 

Application for Pesticide: Other 156138 

" I 

I" " N"",b." 1',_ EPAP,,,,,",, I' 

14. C. "', W Nona D Relllr'.tt&d CcmpanylProduct(Namc) IPM. 22 

PREpe brand r I Boll 

Is """') Is. Expedlled Rovlew. In 3(c}{3j 

Rhone-Poulenc Ag Company (b)(i), my product is similar or idenlicalin composition and labeling 

P. O. Box 12014, 2 T. W. Alexander Drive 10: 

Research Triangle Park, NC 27709 EPA Reg. No. -

o ChfJGk if this is a J'Wwsd:kf}$S " N. 

01 

[" Amondmenl· E>:piain bo1ow Rnal piloted labels in mtpOnSQ to 

~ Rewbmfukm in rosPOO${) to Agency wlUIr datIKI I- Agency kltterdated .~""~- ---,-----, 

!= NotifICation· Explain below. I-

°Me Too' AppllCa~O(L 

Othor· oxpkiln below, 

: Uro additional page{s) if necessary. (For ,cc\lool and &1e1km II) 

Reformat of labels to include easYcto-read tables for use directions and update of 

patent statement on front panel of .label. 

1111 " ". II .. d ,,, 

IUo" 

I Yes 

12 ~h ..,,,, BYOS. ~" f--

No No No I--j~~~~ I--I ~;;;;;, No po< I 'Y"~:~ No. P'" 

• c.rtiflcatlon must b. wgl. container Polckago wgl. 

r.-

I 

I" Si'~'1 '" "', .. Coo"'m", I 5, Loe>':," ~"'" I 

Ou.oot n 

1

6 , ITo P","'~ 1= DOlhCr( 1 

~ ;to rr; I"""" " :.,' ' • Cod'J 

Warren A. Davis _co"v. Regi strati on Manager T: • 

•••••• 

15. Dat, 

I certify that thl! statemcnts I have made on this form and: aU al!ru:hmoots themto arc ~ncaJrnre Md ccmp{el( : 

IlICkoowfOOgo lhatany knowingly taloo or misk:tuding slatemool may be punishable by line Of imprisol'UTlMlI or •• .._ .... , 

both under applicabto law, ••• •• ••• • • 

12~ II), I' Ti"" •• i •• • 

• •• 

Senior Registration Manager • • • •••• 

. ,• D,,. • • • 

• •• 

l'tT: Warren A. Davis June 30, 1992 

178 t'A ronn ti3ttl-l II1vv.12-80} \Vhf",· EPA y".w ,'oopy 
<, 

• 

'(j!tl~€;RWf~2H~~~r P\Jh!ic J'tpbnlnu twd40 for thh coiU:ction of infcrmatiN\ is 

Mtit> (~/ to «4Ti'!:00 D,t!5 hour f*t r€*~e, iR:lwdln;! nill¢' for reY!$¥{tiU Imtrw;:OOf;e, ::,urthiftiJ existlfl{) d"t1! SG.ifCCS" 

9/Ilth;/ ¥4 AJ;infc ir,ing the ciM~ ooe-OOd, nrrl ;::(~}t$t h"i@,~ fWii,W'k,*, t?,? i'4t (ilfer jv, of lnfbt;r&tlGf1. ~$id (;oorr#iltg 

c."d'j,i~-m0 :w/0t:h eBtiuat(' or &if( Gth>ef P1 thlii-t0ttect:1m ¢f lnf1HlMIt:l¢h", including tL'G(}ottim'd for r~jr(J thit> 

bt..rttRh, 10 Chid, rrd(),®4tf&1 Pulley 8rBf!!;l1, hAL Ehv!rGf'fflifflt2!t ¥ntccthm Allt:n.:y, 401 N Strt~t, ~\l, IJtnhfngtoo, DC 

2Q4(.,(;; ",4 Hi tiw Ci f itt Qf In{w§"£t Jon i'ird R0Sui¥i£ry Aff .. ) rs, jJffl©¢ out l1.&"i!'>@!mlM''it ¥a flu6;wt, tI~$h\ngt'A. DC 20503. 

lhh form is to be !J:$Nj tor sit ~tlclit!6?'m for r1&W rq;i,gtfat!{)i1, end USl'? fHtgistrtitiOO, rmmrtiwmt, 

tetlJbqis$i&1, t~ ~tjc~ti6n$ fOf not1flc@tlcns. final pr1nted lWbttlhB. r*regletr~tjcn. ett. In c(~r to proc~~g wn 

llflPH~du< fer a mtI f%jisirMioo otl.lMlittcd on thit form, !tV! +at lowing ltifitertlJl!1tl$t M;n:!ff{moy tim ~pptlc.,tlOl1: 

, tc/tiHc-&tlm "Hh E~t to ClUtier. of itlllt& (EPA form 8S7tl·tJi). Uf frot exwtptw by 40 en: 152,S1 (b) (4)); 

Cud ~«AtI{jt Sfhtl'&Mlt ot fotmJta (EPA Fll:t'\l'I WrtH.); 

fMlNhHM'$ j>;jfi StbtdllUlt (EPA !©m ~rt.H;71; 

c flve fT0iu 01 I;ili.eOngi 

,>, ,,,"'_ d '*'ry' ihta ~ltted; 

knlhl), tette!'" llhere apptie&b!e; 

L Nittlf@\(' ;Aery kiilite. 

~h,;,h:n ij l~\lriJ· L'4 $h«Jld first be ~fttcd in tht! form of draft tilbetl< with etl apptiCllt\.(i()G for flWI.< 

f'i!g<4,;4t\Oi;L S"u;h drwlt !li/OOf( my be In tile form of typod lllbct text on 6.5 K 11 inch JWfXtr or a /OOCkup of th¢ proposed 

t!'lb&L $ iii mv::hm, it l1-lwutd be con1J.trucred itl $O!:h i1 lOll)' n$ to fnc'ilitl!te storage in an ILS}( 11 inch file. 

_.k14) wigrMicynly W!l'A\!er thsn 8.5 x 11 indws shnUtd be ~ted co 8.5 x 11 inch f)'lper for stkmiuion. 

Stbrdssim; d \tITlE - Oat@ l;0tt!!iHel In g~rt of this UWtic3ti«l ml.ffit be sr..>lmiitttd in lKccrdMice with Pi!. lIoticc &-S. 

SPf;S:31fl:£ :rm~AUCl'ION2! Plt1{llW read the jnstn.ICtiOl'W nsted betow before- Cl':tl9tet1r;g this epptlcation. firM 

dttur0);n tM typt of tt1littr'ltj",..., ectioo, listed in Bto.::i; A, for which you llN sul::mitting this ~ticlltjon. for 

appl.10f1il1<74 g;Jfmjtted in cy.o«tioo uith liew R&gigtfl'lthm ecti1O$, Sectloos I. lIl, and IV must Ire Cooptlft«i by th~ 

appUU_DL hr Ilppticat!«w 5tJUaitt«i In c~tioo with I'!!MOded registratim Ktians, re:wt<l!issl(ltl$, rotiflcntlom, 

n,rfr<tr&-thx0, (\U:., S«;:tloos 1, H. and IV!WIit Ire twpleted by the upptlcMjt~ 

IItoc± li C1:--etk the appr-qufaie n<::tion for whieh you are ~ittfng- thh fONfi. 

~klJ:jlL.I ~ !lih MiCtfeo oost be cOIfptet-OO. u appHubte, for all registration "tlom. 

1. ~¥lfJ~A£'t_ liul!lber - lrw:rt y¢W' c~ 1tI.JiIbw~ If t.WWt hos ooen ;1I;uillMd by EPA. Thill! li\mber ~y have 00en &!lsigned 

to 0/00 M g b$!$1e resistrMlt, a di;;trlootor. or 1'1$ 1m ¢stabtii:h!r.ent. tf 'IOOr produet i$ t'egistsred. imert the- i'r«b:t 

~, 

1:. 8'k i'ndxt ~ ~ If k~, Htt In the I'!llffIe and PM nu'!ber of the £PA Product MM'IIX/!!r. 

3. C-tM,.HipiUw.·' 5f*Cify the fU'OflOS;,ed clm:slflcatlon of thls pr-.xJtiet. 

4. Prvnt IUiffiP ' t"lter Um Gooptete product name C!f thlil $xwtlcide IJS it witt appear co the ttk.et. The nbIOO m.mt befff*.f-ifi-( t& this pr~t onty. OupticatiOfl of NIMW is Mt pcn§ltted among products of the SMe c~. 00 Nt inett.>dr! 

£!ftj tn;-v) h4if;0 tff e~ lioe ilimignaticns. 

• 

';I. ~ AU Nfu_ -of AppUC4llt • The 00fIl¢' of the firm ¢ot' pef'$on -erd eddre$5 nhown In your np-plicatfon is th0' person or tim 

to 0";",,, Uw <"1 __ i)ittrat!M witl be- iHved. tf roo arc ectill9 in b¢hatf of MOthsr perty, 'tOO _t sul;Qit oothorhat'jon ftw! 

tkH potty f{; o:,t for them in registrlltion matters. Ah appliclmt not rcsiding 1n the United States IWSt h~ an 

U',;1r,d 1;01 iYjW'i! raiding in da United StutCi to act fO!' thrun in ul t regit-trlltion matters, Tha- I1MIe lind cOilptete JlWn ir.; 

t;OO;-tM (;1 nuh til agent JWt.t XC~ this i'lppt ieaH!)fl. • 

6, E:"p,dit01 l1wieu " fHRA $«tiro 3 (c) 3 (II) prQvidtti; for excpedfteci revlw Qf appticati«n for t'eg\str.atton, or ~t 

h H_;,-tt1'S tt-¥!lttr<lticns. that Itte IIlmitar or identi.;:tli to other pesticfd¢ products that {Ire C:Uf'rmt[y ft!gJsured with ' 

th'ifA. ir, Nevr for 'f$IJf .epptic4tion to be elfglbte for expedited t'lr«lew, you Iftnt provide Uli- wIth the EPA ReghUl'Itibfl 

fu~-H ","0 VG4K-t N>!m" of lilt product '(I:lU betle~ b ;;Imitl!lr H> or identfceL to)'tlUr product. lhe prodoct m.nt b& 

$iw,bx f'd' i,j,':ntj,:;n-t in W1th icrnooll'lt'ion &nd labeted tmlil'$. 

~::-~1~_L9{L_Lt Hoi&- ,«,ct),:;--n tu!'.t be cornptetti-d fer all IlppllCtltJorn; !iubmltted to _nd the r¢gistratiM \WIly of tJ 

Cl.IrH:1d1y H?si;lMH, F"vm_oc-t {fu"1&.ru:Im&'lt), for -& t!"rslbll!llIst{;(l In rll'$pOfI$C to -fit! A~y tlltter. for Mtificati()f';$ to the 

Ageru:;y, N/ lLe ;;,d:wh$;Gfl d la'.nt printed taootlng, fer retftgi&tratlen and ior ally ether "ctiM that per (<liM to a IIp&dfi<: 

tea'!3:+l lhili- se;:;tlon is llil!. Y1 112 \Je.eU fur 3 ~ 1!pPl ketion fol" f09huatloo. 

1. sli"-k,r - C/;-ttd; Uw nppllctible block and provide the AlJC(!ty letter date if appr-oprbte-. Provide <I: brief 

eA[oL-;,{/Hk)t', ,1{ (fa P'ffpDte{1?1 for tho !to.A:missicn, juth M lithe ad:1iUoo of II tite, p;»t or crop (specify)"; "~f\rJ the 

CtnrLhntk;( St;;;tww-ot of formuta by •••• ,; Olrercglstntioo stlb1liss!o-n"; geN-rnt t1l-tx!t nwlsion of We dirocti()fj$. ... Attach 

a Uf-4rM. t0i ... if tdjltiumt §pac¢ is needed, 

•• •• • ••••• SEC'J.,.:tmLJ;,;UA (pco;taging and Gontainer Information) ~ This Section ~t be coo;pteted for lilt 

IIppllu;nM$ M1:mhted '11' ~tion with new rc-gh:;tration or appilcllIbte IWrMdn!mts. 

1. TYf:W of p¥_~in@ , ClVl~ lIppf''Opf'iate btlW}: if yoor prG<duct witl be pw:kaged in the indicat«-! packaging types. 

Jrrli(.(lbJ the fd;e of '«w indlviduat ptlCkeu 5'hd /"lI.tI'imr per retail container ~ 

2. TYf:W rA *"tJ"·1klhtain&·· tnd"lcllte t}'f» of (;MtatOCr in which prcQ:Jct will be marketed. 

3. lOCinloo -01 ~t C«tteqt\-·; ~ify the rna contents of all rtttsit cOfltl'llocrs fer your pr«.kJct. 

4. Shms) ef it&t!}\! C4nt'\t~.~ Specify the rw-t contents of :.U retail c«1toirw-t's for your product. 

5. l«:0UM ~>f~:!}lnx:::ti_ - Indicate the location ot tllf:! \JIl@ dlreetiooa for your Pfl:x:k;ct. 

6. 1ItarK#:1' in Iti.io::-t. t;Wet hi tlffixcd 1;i) pnxir.::t ~ Indicate the method produ<':t l~t \5 QttllCh«l to. retail f!WltaiMr. 

• •• ~IOO-,;,!!! :(Cgntstct POint) . This Se<.:tloo _t be cOl'f9teted for ntt appticattOO$c for Regilltra,t"ioo actions, 

i.e., fN .. pr~t!i r«llstfatioo, r~l£sIM, ~·tQO." reregillltrlltion, etc. 

1-5. S*tf~e)(p!MIDttlr-y, 1· 79 

6_ EPA Use Cq!y_ 
• 

• 

:1:2: FILE ROOM 

DOCUMENT CENTER 

lI!2lI' 

PRODUCT MANAGER 

PAll (ROOM 263) 

FRANCES WRICE 

TXPE OF REGISTRATION ---~-~ 

PAST - TRACX ACTION (with d.t~:~out '~ d.ta~~~) 

This action has been determined to be a fast-track action 

by FEPS and m.w& be entered in the PRATS using one of the 

following codes: 

160 - Application for "me-to" registration 

170 - Application for registration - old chemical - "Metoo" with additional use. 

300 - Amendment - label revision - administrative (no 

data required). 

305 - Amendment - label revision - data required does not 

need HED/EFEO review. 

310 - Amendment - added "me-too" Use - no HED/EFEO review 

needed • 

345 - Formula change - no HED/EFED review required. 

REGULAR REGISTRATION (with data/without data) 

24C NEW 

HC AIO!HDHEHT 

RB8UBKISSIOK (r •• pon.8 to Agency ltr) 

PlNAL~PRINTBD LABELS 

OTRER 

HB88AGB' __________________________________________________ __ 

180 
"---------------------'-.~----~--- .--' 

• 

• 

y/-, 

.,. 

" ,. 

;, " 

'- L;) , D ',' , , (j 

,~ ;, o,! , i. ;: if!; 

• ;:; "4~wt \C , , p 

, '-

';i 

. , 

181 
, 

• 

Mr. Warren A. Davis 

Rhone-Poulenc Ag Company 

P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, NC 27709 

Dear Mr. Davis: 

Subject: Alternate Brand Name 

PREP Plant Regulator for Cotton 

EPA Registration No. 264-418 

Your Submission Dated April 23, 1992 

-

The additional brand name llPREP brand Ethephon Cotton Boll 

Openerll is acceptable and has been included in the files for this 

product. 

Enclosure 

Sincerely yours, 

Cynthia Giles-Parker 

Product Manger (22) 

Fungicide Herbicide Branch 

Registration Division (H7505C) 

182 
~------------~ .. -~ ....... ~ .. --~ ~~--.--.... 

~ RHONE-POULENC 

2'" , , 

" 

, 

RHONE-POULENC AG COMPANY 

ETH~92-4 

April 23, 1992 

U. S. Environmental Protection Agency 

Office of Pesticide Programs 

Document Processing Desk 

Room 266A, Crystal Mall No.2 

1921 Jefferson Davis Highway 

Arlington, Virginia 22202 

Attention: Cynthia Giles-Parker 

Product Manager (22) 

Fungicide Herbicide Branch 

Registration Division (H7505C) 

Dear Mrs. Parker: 

RE: Request for Alternate Brand Name 

PREP'" Plant Regulator For Cotton 

EPA Reg. No. 264-418 

In reviewing the files for this product we noticed that there were several versions of the 

product name used by EPA and Rhone-Poulenc. For the record the product name 

originally registered is PREP'M Plant Regulator for Cotton. We now desire to register an 

alternate brand name for this product: "PREP brand Ethephon Cotton Boll Opener". 

An application for amended registration accompanies this cover letter. We believe that a 

simple notification should be adequate to allow immediate use of this alternate brand 

name. II you have any questions please contact me promptly. Thank you for your 

attention to this registration request. 

Sincerely, 

Warren A. Davis 

Senior Registration Manager 

., • . 

• 

•••• 

• 

•••• 

• 

. •• • , . • •• . , . · ., .' . 

• 

· . ., , . •••• 

. , . . , . • •• 

POBOX 12G'~? ',) i, ~\g-Jr,FR!)H'-;: 

'1ESI:IRCh -"I"-",~i' ~'4J"{ L: '~~-:J 

!gEJ! 5-19·2\)((1 

j,'.'U1tJm-:if0lL rne~ 'u'.U[n -i'I'i): "'J f.\ -:-,';!.!' ,,< i' .'('1: "lj' 

N":::SNc'"y,I,L i11:;FHl'J[;{'!r,ah': U"',:>' j f ~",.J!;;~" n'f'ji: ·\1 u,',U"'_'-c n', '-'._ 

183 

. 

•••••• ., • • 

• ••••• 

• ., • 

••••• • • • ••• 

•••••• • • 

• 

•••••• 

• • ••• 
1" . 264-418 I" 

I 4 Com~if"d",t(N""") ~, 0 NOM 0 RestrittOO 

PREP Plant Regulator for Cotton 

15, Na~nndAddr(tS$ . 

Rhone-Poulenc Ag Company 

P. O. Box 12014, 2 T. W. Alexander Orive 

Research Triangle Park, NC 27709 EPA Reg, No", ______________ _ 

1'. 

o Check /I fhi$ is a Il&W sddtoS-$ 

11 

Amendment· Explain below 

R&&Ubmiukm in rfI'&por1lW to Agency Jetter datCdL ___ _ 

NOlmcarkm~ Explain below. 

Produc, Nam. 

"Mo Too· App!ic3110ll 

OthGf' explain below, 

Usa addilional page{$) II nocossary. (For lIection t and Section 11.) 

Request for alternate brand name: 

PREpTM brand Ethephon Cotton Boll Opener 

Section III 

8:" p :' ~ :' hf~~'M~:---~ NO-.,pN-. ~,,·~y.~,~:~--~N.-,pM--1 

• CertlfIcBtJon must IxI I container' PntkageWQL I conlntnor 

I'~':of,""c;t;io' I" S'''(:) 0.1& bulk IS. ,'~'::"'" 

. "~ ITi'" 

Warren Davis Registration Manager 

I OOrtify that the $ta~mMlfg I have mnde on this form and a!l attGchrnents thentlo are [roo, 3<:Ctlrate and complete. 

I acknowledge !hal any knowingly false or mtslca:ding s!awmGnI may 00 punishablehy lioo or tmprlsoortWrlt or 

both IJtlder applicable taw 

1 4' "''''' "_ Warren Davis 

YA tRw.,. ... , 

I' Titl, 

Registration Manager 

WhiI4· EPA 

• • 

184 

.. : . 

..... • • 

.: .... 
, 

PAPERWORK REDUCTION ACT NOTICE and INSTRUCTIONS 

PAPEBNQRlS REDUCTION AC'll'fOlElb"E: Pubill:) r~rt!ng burden fcl' this coll«tion of infcnMticn is 

ontiwmted to u\{"r~ {),as hoor per reSfxmu" Il'WtUtHog time fa/' rwtwfhG imtruetiOO§, searching eX\St1flii datil- scure:ci>, 

gatherlr',g and ff41ntulnfng the data ~, ;1!ncl t~litf. M('LtM~j!%t· the eottw:tion of inflUl'llOtioo. Stnd ecmwffiU 

fegarXIing the burden estl!1Jil1te or any otliel' d!~fif/m$ IXIdifeHijif'ljef"'inf{;ffMtioo, Including iW9gostiem for r«fuclflS this 

burdw, to CMot, fnformatioo Potky flrGt'idl, liFtCl, U.S. Envlr~t-l1t Protection A'J«\f:Y, 401 M street, S'ri, UaShingtoo, DC 

l{)l.Ml; W1d to th~ Office: ef lnforlOOficn &rid i/($jtatwy Mhlr'1t, OHlC{t {If ~t &fId Budglit, \;'llsi1iogtcn, DC ZOS!);. 

INSTRUCTIONS: ihl$ ferm is to Ix: wed for aU aprl Itetiora for mw registratIon, Mid U$C reregistration, ~ndment, 

r{l>"ul;mhltiOfl, to apptic<ltloos for notifiCl>tiOO$, flrwt printed tMK!Ung, rer¢Gf~ltrlition, etc. lit order to ptot1?!;5 11ft 

D~lir-ul1cm fH $I r&l< regh.tratiOfl stbnittw (li"I thlu fl'ifill, trw tQl!cwif\9 tMlte;lul _t aee~ the apptltatien: 

1. c&nlfkilltien with Relilp<!ct to Cit&tlm i;11 Oattl (EPA fen!! 001O·Z9}. [[1' rIDt t!.I<H'pt-ed by 40 CfR 152.81 (b) (4)J; 

~. Culfidootlal StntS!ll'!f1t of forl3JLs tU\l\ f'j':.rn 1i$7U·4); 

3. f0rn11ator'lI Exll!!i'iptioo $U:t~t (!fPi. form 1W1O-~7); 

4. ftvt copies of draft [liNl in;l; 

S. Three copilu of 1M'!'{ oot6 stbfll tted; 

6, j\;Jlherlzntlon letter where ~llcabte; 

7. It4tdces Idlere awl ieante. 

Stmbf-icro M l.abeling· Ll1belir.g §hoold fint bI: sl..f.Jmittoo In the f(ff1!! of draft iabels with all ~!ications for nw 

l'egiStT0Hoo. toeh draft latwls may txl in the fOI"ffl of typed labet te];t" 00 a.s ;t" 11 inch,paper or a ~kl4> uf' the ptop%ed 

1.1. If pr;ipllrcd 00 a moek..", It shootd M conetfU!:t«l in Wdl a WIlly u t$ fMHit4M Jl:.tor9 in an tJ.5 X 11 Irn::h fHe. 

Moclop !clK!t2 signHicM'!tly _lier tl;lIft a,5 x 11 lnches 11;00ld 00 IMUlted on 8.5 x 11 incll p;!IpI!'r for uuhnia!!;ioo. 

S'l..tBiedoo of (lata ~ Data sul.nltted in s~rt of this swiicntlCfl nnt bI1 tWmltted in attordrocll" with PR notice 86·5. 

SPECIFIC INSTRUCTIONS~ Pl!'iil.t'J read the irwtructiOlW. I lilted 0010# be10N! cOOIpleting this appilcation. fif!>t 

tktcrminl' th~ tyPe of ,cglstrllticn action, listed in Elt<xk A, for l4lici1 yw IIIre tut:r.ittina this applitat1«l. forapplicDtiOl"W $til;:tilitted In c~tioo lIlth New Rcglstntioo octltlf'lS, tecUCflS. I, lU, nod IV lIl'..&t be ccnpleted by the 

awlitM,t. for nppllcl'ltiorm. submitted 10 COl'¥'leCtion with ~ registration aetiornl, r;:J;obmissions, MtifiCQtlOfl'll, 

reregi~fratjOO5, etc., Sections I, !I, nnd IV ~t be completed by the applicant. 

Bloci A - Check the appropriate actIon for which yc~ are submitting this form. 

~QLI - 1hl$ &ecticn II1mt be coopleted, iI-S rwllciibte, for nll reglstratlOfl m:tioru;. 

t. ~~t JfIJIober - Insert your ~ ~r, if ~ hn ~ owsisnod by EPA. lhb IlUII't»r may have bMm assigned 

to yV,J liS u basic registrMt, ij distributor, Of iI$ 1111 estnblishmoot. It your product fs regIstered, ilU.ert the PrOOuet" 

2. -. EM Product ~ ~ If i;rnIol!l, fill In the I\i'lrnC MId f'H nud::rer of the EPA Pr«kIet ~r. 

J. Pr~Ad Chmsificatioo ~ SpecifY the proposed tlMlification' of thh product. 

4. Pnxhcr U- - Enter the cOl!?tet<! product mma of this pettfdde os it \,Iill appear on the label. Tho M!OO'!lOSt be 

~tdic to this produ!;t ooty. lluplicatlotl of ~s 1$ nGt pernitted amoog pt~t$ of tll*,aIM G~. 00 not Include 

lillY btlWld ~ or c~ line Oc$lgnatlon:s. 

, 

5. __ &'V,j At.kiress of Appiic:td'lt ~ The n!lI!IC of the firm or p!i:r!Kln ar.d adcirfl$$ mMifl in your application h the persoo (lr firm 

to it?KlIiI too registratiOfl will be iutted. If you .ore aetil'l9 in behalf Qf utWthl:r p$rty, yW _t zt.bdt authorlZf.ltlon from 

tlwt jXlrty to act for them In registrlltiOfi matterti. An appfic:mt not rHfdII19' in the United St4tU must have an 

wth"rlzod $gmt residing in the Unitoo Stat"- to <lct far tnil«! in alt regiliitration motters. The rmme and coov:>lete maUl' 

addrti\s of !Ouch lin ~t ra.nt .KGOI!pfmy this appLieatioo. 

6. Expedited 

to cX\$ting 

RWlew 

reglstretiQn$, 

- FlfRA sC'Ction 

that ar~ 

3 (c) 

similar 

3 (S) 

or 

prcwhk$ 

Identical 

fer 

to 

('xpedh-ed 

other pesticide 

review of 

~ta 

'appticat10M 

thllt bre 

for 

currontly 

registration, 

registored 

or ~ 

with 

the 1;1'1.. i1) order fol' yoor apptlutioo to be eligible for expedited reviw. you IW§t provide us tiith' the EPA Regb'tratlon 

N~r nod product MIlle of tho product ymI bd iow III dmHtot to or i<knti"",t tQ )'<lOr pnxkx:t. Thll product !11U$t !a 

almHu M" iodentical in both fenmlatiM and laMtW U6'Nh 

• 

!Jt.M 

~~ - This soctien must txl cO!l'fIletw for all "PPI icatioro albilitted to ~ the r@Qlstratlon ooly of ($ 

JW1fr~tiy reslst\rea product (~t). for l'I resubmissiQf1 In response to an A~ letter, fQ4' notif\('fttiolls to the .':i::-c;, for the 3ubBlsf;lOO of tim.1 prlntm:l laOOlIns, fer rl1ft'ginratfon and fer 'IIfl'/ ather 1Ictien that pertaiM to a l!f1%Hic 

~~rtaltr-!£r%, ~~ This £«:tloo is m!. 12 t:t used for n r$ <lfPllcation fQ4' reglstr-ation • 

• 1. ~Jh:t (\'f~ission - Check the npptlcabte MlXk MId prcvitkt the A!};ency tetter date if apProprlllte. Pr,wide a brief 

u"-IhmatlQfl oi 'he purpose{s) for the Ilubliission, sueh as uthe <ldditioo of G site, pest or crop (sp<U:ify)"; II~ the 

• Cenf)OOnti~·St&t/!lOOrlt of formula by ••• "; "rere!lh~traden lR.ibmission"; !lfUWral lnbet revision of U$C d!r;x:tions." Atta;::h 

.... III "~;Jilratl: l'l1e if additIonal s~e is Mmfud • • • 

• ~IQU·Cl (Packaging and Container Information) - 1his SectlOO !l¥J$t IX: cct;?letoo for nil 

'~.¥:lItiont·l'~ittGd in COOIl('ctlon ~fth MW reghtratlen or lIf'Ptfcabte ~ts. 1. Type of ~il'l9 ~ Check the ewropriate block if your Pf'ocluct ~ill txl packaged in the ind!eat¢d packaging type~. 

iwa!\:ilte (\Ie sJUt of the indlvil.k.ml packets and f\lJ!ixor per rhtalt contlliMr. 

2. Type of JtctaH Container ~ lndicl1t(! type of t:ontnlMr in l4hich product IIHt be marketed. 

3. locatfott qf ltet contents - Sp.u;lfy thl)' net Cmlt(flt!l of all retail centaiMrs for your pNlduct. 

4. Si:r:c(s) of fl:etlilH CoI'ttajou - Spolclfy th~ Mt coottmt;; of alt retail contaiMrs fQr yotIr produet. 

5. locatfoo of Use nirectlQr'$ ~ Indicate the location of the LIGC directions for '{Otlr product. 

6. ~ in which [abel is affixed to prcdJet - Indican the Mthod prodJct labet is attaclted to retail container. 

SECTION IV (Contact Foint) - Thi!). SeetiM ItWt be c~leted for aU eppl \cutiom. for Regi$trlltion 3cticns, 

I.e., new prodlxt$ r~l$tration. r«ub!lln:ion. ~me-too." feregi$tNltien, etc. 

l-S, sett~explenatorY. 

6. EPA Use Onty. 185 
• 

• 

DATE: if - J 2 - f'J 

TQ: FILE ROOM __________________ _ 

DOCUMENT CENTER ________________________________ _ 

~DUCT MANAGER -'.,)""-',,1""-___________ _ 

PAM (ROOM 263) 

FROM: taz~ 

TYPE OF REGISTRATION 

FAST - TRACK ACTION (with data/without data) 

This action has been detennined to be a fast-track action 

by FEPS and ~ be entered in the PRATS using one of the 

following codes: 

160 - Application for lime-toil registration 

170 - Application for registration - old chemical - "Metoo" with additional use. 

300 - Amendment - label revision - administrative (no 

data required). 

305 - Amendment - label revision - data required does not 

need HED/EFED review. 

310 - Amendment - added "me-toon Use - no HEDjEFED review 

needed. 

345 - Formula change - no HED(EFED review required. 

REGULAR REGISTRATION (with data/without data) 

HC NEW 

24C AMENDMENT 

RESUBMISSION (response to Agency Itr) 

FINAL PRINTED LABELS 

~ER MESSAGE: ______________________________________________________ _ 

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Mr. Warren A. Davis 

Rhone-Poulenc Ag company 

P.O. Box 12014, 2 T.W. Alexander Drive 

Research Triangle Park, He 27709 

Dear Mr. Davis: 

Subject: Food Additive Petition 1H5603 

Prep Plant Regulator 

EPA Registration No. 264-418 

Your Submission of 11/15/90 

The Chemistry Branch, Tolerance support, Health Effects 

Division has completed its review of the subject food additive 

petition, recommending against the proposed amended tolerance of 

4ppm for ethephon on cottonseed. You may refer to the enclosed 

copy of their report dated 11/25/91, for a detailed discussion of 

their analysis. 

Encl'osure 

sincerely yours, 

Cynthia Giles-Parker 

Product Manager (22) 

Fungicide-Herbicide Branch 

Registration Division (H7505C) 

187 
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• 

.. UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 204&0 

iWV 25 1991 

Memorandum O..-I"ICEOI" I'I!;$TICIDII ..... ND TDXJt;; SU.STANCh 

SubJect: 

From: 

Througb: 

FAP#IH5603: Response 10 Dala Call-In: Ethephon (Prep) In and/or On RAC 

Cottonseed (Amendment of Existing Tolerance) and Processed Cottonseed 

Commodities Refined Oil, Meal, and SoapslOck (New Food/Feed Additive 

Tolerances). MRID# 41704501; OEnN 7476; OP Barcode 0159333. 

Robert Lascola, Chemist I.....? 4' 

Chemistry Branch, Tolerance Support '-fH>O\cW «KATolerance Petition Section ill 

Health Effects Division (H7509C) ;; 

Chemistry 

P.V. Errico, 

Branch, 

Section 

Tolerance 

Head 

Support {I' 

,,() J:, / ~ 

Tolerance Petition Section ill 

Heallll Effects Division (H7509C) 

To: Robert T.ylor~;.Alleo, PM25 

FungicidelHerl>icide Branch 

Registration Division (H7505C) 

Rh6ne-Poulenc Ag Company of Research Triangle Park; NC, submitted a petition dated 

November 15, 1990 in partial response to requirements contained in Ille 1988 Oala Call-In 

Notice of the Elllepbon Registration Siandard. Specifically, an increased tolerance is proposed 

for elhephon [(2-d11oroelhyl)phosphonicacid] on Ille raw agricultUral commodity coltonseed (4.0 

ppm; !he existing tolerance is 2.0 ppm, see PPIOF2312) and new tolerances are proposed for 

Ille processed commodities meal (24 ppm), refined oil (8 ppm), and soapstock (16 ppm). The 

studies containing !he relevant data have been submitted previously (MRID# 41704501 for 

cottonseed; MRID# 00030190 and 00122423 for processed commodities). 

Tolerances for residues of ethephon inion a wide range of food/feed commodities and ruminant 

tissues and milk are currently established under 40 CPR § 180.300. Food additive tolerances are 

established uoder 40 CPR §lSS.27oo for ethephon inion harley and wheat milling fractions, 

except flour (5 ppm) and sugarcane molasses (1.5 ppm). An experimental use permit for 

ethephon residues on sugarcane molasses a ppm) expired July 14, 1988. Feed additive 

tolerances are established under 40 CFR§186.27oo for ethephon infon harley and wheat milling 

fractions, except flour (5 ppm), sugarcane molasses (1.5 ppm), a1d raisin waste (65 ppm). 

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I 

2 

Toletances are pending for sugarcane (0.2 ppm), sugarc3!le molasses (3.0 ppm), and bagasse 

(0.25 ppm) (pP#OG3840/FAPNOH5595). 

Application to cotton accounts for approximately 89% of U.S. ethephon usage (preliminary 

Quantitative Usage Analysis of Ethepbon, J.E. Hogue, EAll, BUD, OPP, EPA, Jannary 1988). 

Ethephon is the subject of a Registration Standard dated 3/31/88, an addendum concerning 

Additional Data Requirements for Mooochloroacetic Acid dated 5/24/88, the Ethephon Guidance 

Document dated 9/88, and a Registration Standard Update dated 2/13/91. The relevant data 

requirements addressed ill this petition can be found on page 22 of the Update: 

The current approved labeling for etItepbon on cotton specifies a total application 

rate of 3 Ib ail A1season. Data are required depicting residues of etltephon and 

MCAA (monochloroacetic acid) in or on cottonseed harvested 7 days after the last 

of two applications using a representative EC formulation. Ooe treatment should 

be made at lib ailA when 50% of the bolls are open, followed by a second troatmoot 4 days later at 2 Ib ai/A. Application should be made by aerial equipment 

in 2 gal water/A and (in separate tests) ground equipment in 15 gal water/A. 

Tests must be conducted in AZ (7%). AR (7%), CA (18%), GA (2%), MS(12%), 

NM(1 %), OK (2%), and TX (35%) which accounted for approximately 84% of 1988 

U.S. cottonseed production (Agricultural StatUti ... 1989. p. 108). Alternatively. 

the registrant must propose increasing the es.tablished tolerance for residues of 

ethephon in or on cottonseed from 2 ppm to 4 ppm, and must amend all pertinent 

product labels to reflect a nwcimum allowable use cate of 2 Ib ai/A/season for 

application of ethephon to cotton. 

When an appropriate tolerance for residues in or on cottonseed is determined. 

foodJfeed additive tolerances must be·proposed. Based on acceptable data 

from a cottonseed study, ethephon residues concentrate up to 2x in refined oil 

and up to 6x in cottonseed meal . 

[The 1988 DCI also called for proposal of tolerances of 4x in soapstock, but as noted in the 

Update review of residue concentration studies showed that ethephon residues did not concentrate 

in soapstoclc. The establishment of an ethephon soapstock food/feed additive tolerance is no 

longer required.] 

Conclusions 

1. The nature of the residue in plants is understood. The residue of concern is the parent 

compound, ethepbon. Cottonseed samples must also be tested for levels of 

monochloroacetic acid (MCAA). 

13. The nature of the residue in ruminant animals is understood. The residue of concern in 

ruminant tissues and milk is the parent compound, ethephon. 

189 
f 

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3 

2b. A poultry metabolism study has been required in the efhephon reregistration standard. 

Because cottonseed processed products make up a small portion of poultry diet, and 

ethephon is already registered in cotton, any revisions in the nature of the residue in 

poultry ClI!l be addressud in the rercgi'trationprocess. 

3. Both analytical methods (forethephon and MCAA) arc valid for gathering residue data. 

4. 

However, both also use the hazardous chemical diazomethane as a methylating agent. 

The reregistration update states that these methods should be revised to use a safer 

methylatiag agent, and compiete validation data must be submitted for the revised 

methods. If use of a suitable alternative is impractical, documentation should be provided 

supporting Ute need for diazomethane. Because this pedtion requests increasing Ute 

established tolerance for a registered use, we have no objections to having this issue 

addressed in Ute reregistration process. There is an enforcement method available in 

PAM II for cottonseed . 

The manufacturing process is understood. 

5. The petitioner has appropriately amended Ute label to meet the requirements of Ute 

Registration Standard Update. 

6. CBTS condudes Uta! Ute storage stability studies are not adequate for Ute purposes of this 

tolerance request. The pedtianer must submit storage stability data reflectiag Ute storage 

times of Ute samples which were used to generate Ute residue data. Also, Ute petitioner 

must submit storage stability data for MCAA stored over a similar period of time. 

7a. Pending submission of adequate storage stability data, Ute submitted residue data support 

the proposed amended tolerance of 4 ppm for eUtephon on cottonseed. Also, application 

of ethephon to cottonseed does not result in an increase of MCAA residues above 

naturally occurring levels. No tolerances for MCAA in cottonseed are necessary at this 

time. 

7b. Upon processing, ethephon residues do not concentrate in oil but do concentrate in meal. 

Therefore, food/feed additive tolerances are not required for ethephon on refined oil or 

soapstock. The pedtioner should submit a revised Section F requesting a food/feed 

additive tolerance of 1.25. (5 ppm) for residues of eUtephon in cottonseed meal and 

deletiag lbe FAT's for refined oil and soapstock. 

8. Agency policy wiUt respect to possible tolerances in meat, milk, and eggs resultiag from 

this proposed use is delineated in 40 CPR § 18O.6(a)(2). Tolerances which have been 

established on meat and milk are adequate to cover this increased tolerance on cottonseed. 

Any revisions in the assessment of Ute need for tolerances in poultry tissue and eggs can 

be addressed in Ute reregistration process. 

9. There are no Codex, Canadian, or Mexican tolerances for ethephon established inion 

190 
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RAC cottonseed or processed cottonseed products. Therefore, there are no compatibility 

problems involved in this petition. 

Recommendations 

CBTS recommends against the proposed amended tolerance of 4 ppm for ethephon on 

cottonseed for the reasons delineated in Conclusions 6 and 7b. As discnssed in Conclusion 7b, 

CSTS also recommends that a revised food/feed additive tolerance of 5 ppm should be proposed 

for cottonseed. meal, but such tolerances are not necessary for the processed commodities 

cottonseed oil and soapstock. 

Additional Comment: The reviewed residue data shows that MCAA may naturally occur at low 

levels in mes. This conttadicls 21 CFR §189.155, which states that MCAA does not naturally 

occur and that any item with detectable MCAA residues is adulterated. Confirmation of the 

identity of the ohserved residues and resolution of the apparent conttadiction is not within the 

purview ofthi. memo. However, at a future point the suilllbility of21 CFR §189.155 may need 

to be reevaluated. 

Detailed Considerations 

Manufacturing Proe ... 

The manufacturing process is detailed in the Product ChemistIy Chapter of the Regislration 

Standard. Ethephon 87.3% technical is registered under EPA Reg. No. 264-276. CBTS 

concludes that the manufacturing process is understood. 

An impurity in ethephon, the monochloroethyi ester of (2-chloroethyl)phosphonic acid, can 

theoretically degrade to monochloroacetic acid (MCAA), an extremely toxic metaholic inhibitor. 

Under 21 CFR §189.155, MCAA has been prohibited from addition to food. An addendum to 

the Residue ChemistIy Chapter of the Ethephon Regislration Standard (see D. Edwards memo 

of 5/24/88) required data for MCAA for food and feed crops for which other data were needed, 

including cottonseed. A proposed waiver for MCAA testing in certain commoditins was denied 

(see D. Edwards memo of 1112/89). 

Proposed Use 

The formulation proposed for use is Prep, which contains 55.4% active ingredient (6 lbs. 

ethephonlgallon EC formulation) (EPA No. 264-418) and is used for hoth preconditioning cotton 

plants for defoliation and promoting hoI! opening. The following use information is submitted: 

191 
Expected Conditions 5-7 

Dan After Treatment 

BOLL OPENING 

Hot and Dry, 80 F or higher 

Dry, 75 F - go F 

Cool but higher than 6S F 

Rank cotton 

PRECONDmONING FOR DEFOLIATION 

Hot and Dry, go F or higher 

Cool but higher than 65 F; 

also for rank cotton 

5 

Amount Obs ailA) 

1.0 

I.5 

2.0 

2.0 

0.5 

1.0 

Spray Volume (gallA) 

Ground rue 

IS-50 

IS-50 

IS-50 

25··50 

IS-50 

IS-50 

2-5· 

2-S· 

2-5· 

5 

2-5· 

2-5* 

• ,. For CA, AZ use a volume of no less than 5 GPA for aerial applications. 

• 

Do not exceed a maximum of 2 Ibs ail A for the combined use as a preconditioning treatment for 

defoliation and cotton boll opening. Do Dot make more than two applications to anyone cotton crop. 

For boll opening, apply when there are sufficient mature opened bolls to produce the desired yield, but 

not later than when 60% of the bolls are opened. For preconditioning for defoliation, apply either 4-7 

days prior to application of defoliant or tank mixed with defoliant. 

Do not harvest cotton sooner than 7 days after a treatment with Prep Plant Regulator. 

CBTS concludes that the petitioner has appropriately amended the label 10 meet the requirements 

of the Registration Standard Update, which states that if the petitioner chooses 10 propose 

increasing the established Iolerance for residues of ethephon in or on cottonseed from 2 10 4 

ppm, he must also amend all pertinent product labels 10 reflect a maximum allowable use rate 

of 2 Ib aU Afseason for application of ethephon 10 cotton. 

Nature of the Residue· Plants 

No additional metabolism studies were subntilted with this petition. Previous radiolabeling 

studies ("C-labeled ethephon applied 10 grapes, cantaloupes, apples, and cherries, and "C- and 

"P-Iabeled ethephoo on pineepples - see PP#2FI275; 2GI217, IGl172, and IFlOl6) have 

shown that the only degradation products are ethylene gas and simple phosphate and chloride 

ions, which are taken up inlo the natUIal metabolic pathway of the plant. A similar metabolism 

has been demonstrated on three different crops. The residue of concern is the parent compound, 

ethephon. 

The Ethephon Guidance Document (pp. 14-16) has stated the concern that the residues of 

monochloroacetic acid (MCAA), a theoretical degradation product of an impurity 

192 
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(monochloroethyl ester of [2-chloroethyl]-phosphonic acid) in technical ethephon, may be found 

in ethephon-treated commodities. MCAA is an extremely toxic metabolic inhibitor and has been 

prohibited from addition to food under 21 CFR §l89.155. Analysis of certain food and feed 

crops, including cottonseed and related processed products, for residues of this contaminant were 

required. The data for cottonseed has heen submitted and is reviewed below (see Magnitude 

of the Residue - Field Study). 

CBTS concludes that the nature of the residue in plants is understood for the purposes of this 

tolerance increase request. The residue of concern is the parent compound, ethephon. 

Cottonseed samples must also be tested for levels of monochloroacetic acid. 

Nature of the Residue - Animals 

No additional animal metabolism studies have heen submirled. The Registration Standard 

Update has stated that the nature of the residue in ruminant tissues and milk is known. Studies 

have determined the metabolism of ethephon in cattle rumen and in a goat. Details of these 

studies are presented below. 

In an in vitro study (see 10128183 memo ofK. Ame in PP#2F2711), rumen contents were taken 

from a fistulated steer, buffered, and charged with "c labeled ethephon to a level of 40 ppm in 

a flask that vented to a mercuric perchlorate ethylene trap. At a pH of 6.4 and temperature of 

38.4 ·C the half·life of ethephon in rumen was found to be, in three identical experiments, about 

6 hours. After 18 hours, 85-90% of the "c label was recovered from the ethylene traps. Of 

the residual activity in rumen after 0, 1,2, or 6 hours, 72-104% was accounted for, by Ge. as 

ethephon; the proportion of residnal activity accounted for as ethephon did not decrease with 

time. 

The viability of the rumen contents was demonstrated by following the production of fatty acids 

(acetic, propionic, and butyric), which was shown to increase with time. (Volatile fatty acid 

production is associated with cell growth and gas production.) 

In the goat metabolism study (see 6/29/84 and 11128184 memos ofK. Arne in PP#2F2711), two 

lactating goats receIved daily doses of ,'(; labeled ethephon equivalent to 10 ppm in the diet for 

7 days; a third goat served as a contrO\. Urine, feces, milk, and blood were sampled daily; 

volatiles were collected for a 24 hour period .OD the 7th day. Goats were sacrificed 

approximately 16 hours after the final dose. Residue analysis is outlined below. 

Milk: "c activity reached a plateau on Day 4. Recovered activity was 3% of the total dose. 

Of this, 45% went to milk filt. Ethephon is water soluble, thus the residues found in milkfat 

correspond to metabolites. TI.C and HPLC analysis of these residues determined that the 

activity was taken up into nalural products. Of the aqueous activity, ca. 30% degraded to 

ethylene on treatment with base, indicating that this material had been the parent compound, 

et~ephon. 

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liver: The observed activity corresponded to 1.2 ppm ethephon equivalents. No ethylene gas 

was produced on base treatment, meaning no etbephon was in the liver. Protein released by 

treatment with trichloroacetic acid contained 12.4% of the total activity. A small amount of the 

activity was found in glycogen Utat had been isolated from liver, but only 9 mg had been isolated 

from 10 g of liver; apparently glycogen levels had been reduced by Ute stress of dosing, 

confinement, and sample collection. Of the total activity in liver, 5.3% partitioned into ethyl 

ether, 63.7% into methanol, 5.3% into liver, and 27.2% remained in the solid tissue. The 

activity was net further characterized. 

Kidney, Muscle, and Fat: Recovered kidney, muscle, and fat activity corresponded to 1.18, 

0.1, and 0.5 ppm ethephon equivalents, respectively. Of this, 8.5 ppl1 of the kidney activity 

degraded to ethylene on base treatment; similar treatment of muscle and fat tissues produced no 

ethylene. The activity was not otherwise characterized . 

Other: Of the total activity, 31 % was trapped as Co, and ethylene volatiles, 7% was found 

in the feces, and 19% was found in the urine. Of the latter, 36% was determined to be 

ethephon, with the remainder postulated to be a glutathione adduct (with the sulfur displacing 

the chlorine). 

From this information it is determined that the fate of ethephon in ruminant metabolism is 

generally degradation into ethylene gas, CO" and natural products. 

There is an outstanding dnta gap with regards to Ute nature of the residue in poultry, as initially 

outlined in the Registration Standard. However, since cottonseed meal and crude oil constitute 

only a minor portion of poultry feed (:S 10%), and there is already a registration on coHon, the 

fulfillment of this data gap can be addressed in the reregistration process. 

CBTS concludes that the nature of the residue in ruminant animals is adequately defined for the 

purposes of this tolerance request. . The residue of concern in ruminant tissues and milk is the 

parent compound, ethephon. 

Analytical Methods 

All samples were analyzed for ethephon residues by 'Ethephon - Detailed Method of Analysis 

for Residues of (2-Chloroethyl) Phosphonic Acid in COUOnseed, Cottonseed Hulls, Meal, Oil, 

and Soapstock' (SOP 90075; performed by McKenzie Labs, Inc., Phoenix, AZ), submitted with 

MRID# 417045-111. The method is essentially identical to Method I, PAM IT, 12/31174. The 

sample is freeze-dried and ground, soxhlet extracted with methanol and pH adjusted with 10% 

HCI in MoOR. Diethyl ether is added to precipitate any interfering materials, and diazomethane 

is added to methylate the ethephon. Quantification is achieved by GC, using either a flame 

photometric detector in the phosphorus mode or an alltaIi flame thermionic detector. McKenzie 

Labs validated the analytical method by analyzing 0.02, 0.20, and 2.0 ppm spikes of cottonseed 

in triplicate. Recoveries ranged from 70 - 113% with an average of 86 ± 14.3%. The 

194 
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validated level of qlWltification is 0.02 ppm. A confirmatory method, Method A in PAM lJ, 

distinguishes ethephon from other pesticide interferences. An alkali thermionic detector is used 

to detect residues containing phosphorus (including ethephon), and a microcoulometric (Hall 

electrolytic) detector is used to distinguish halogen-contai'ling pesticides (including ethephon). 

Method I has been held acceptab:e for enforcement purposes for cottonseed at a level of 0.1 ppm 

(see L. Bradley memo of 6/3/90, PPNOF2312). 

Union Carbide submittoo a GC method for the determination of ethephon residues in milk and 

cattle tissue (1984; MRID# OOI4226S). The method was subjected to a method tryout (1984; 

PP#2F271IIFAP#2H5357; RCB Request to COB, 915/84, K. Arne; Results of Method Trial 

Memo, 1128/85, K. Arne) on cow milk and liver fortifioo with ethephon at 0.1 - 0.2 ppm. For 

milk, recoveries ranged from 68 ~ 74%, with one outlier at 48%. For liver, recoveries ranged 

from 98 - 128%. The method is adequate for both data collection and enforcement purpnses, 

although it does require two days to complete a set of samples and does require on-column 

capillary column capability (COB Memo, 117184, D. Wright, Jr.). The method was submitted 

(2/87) for publication as Method III in PAM II. 

As noted in the September, 1988 Ethepbon Guidance Document, representative plant samples, 

ruminant tissues, and milk bearing residues of ethepbon must be subjected to analysis by PAM 

Vol. I methods 211.1, 212.1, 231.1, 232.1, and 252. Data has been submitted by RhOnePoulene (1988, MRID# 412962-01) and forwarded to FDA for review and inclusion in PAM 

Vol. I (see W. Smith memo of 11!2/90). 

The petitioner bas also submitted. method for determination of MCAA residues, "Detailed 

Method of Analysis for Residues ofMonochioroacetic Acid in a Variety of Sample Types' (SOP 

9OOSOm, with modification at RhOne-Poulene in Research Triangle Park, NC). The method 

consists of gtinding the sample, extracting the sample with methanol, the addition of water and 

NaOH to the extract, extract cleanup by an ion-exebange column using QAE SEPHADEX" A 

25 resin, cleanup using a SEP-PAK'" CII cartridge, extraction of the aqueous solution with ether, 

methylation of the ether solution, minimal dilution with hexane, and final quantification by GC 

with electron-capture detection. Recoveries of 0.01 ppm spikes ranged from 52 - 95%, with an 

average of 69.5 ± 13.1 %. The lowest demonstrated limit of detection is 0.01 ppm. 

CBTS concludes that the analytical methods for detecting ethephon and MCAA are valid for 

gathering residue data.. However, we note that both also use diatomethane as a methylating 

agent. As stated in the Reregistration Standard Update, "the carcinogenic and explosive 

potential of diazometbane puts FDA enforcement personnel at risk; thus the registrant should 

revise these methods using a safer methylating agent. Complete validation data must be 

submitted for the revised methods. Ifuse of a suitable alternative is impractical, documentation 

should be provided supporting the need for diatomethane." (Footnote 6) We have no objections 

to having this issue addressed in the reregistration process. 

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Storage StabUlty 

In response to the Ethephon Guidance Document, the petitioner has submitted interim storage 

stability study data depicting ethephon levels in fortified cottonseed samples (MRlD1I41668215). 

Cottonseed samples were homogenized and analyzed to confirm the absence of apparent 

ethephon; the homogenized sample was portioned into analytical sets of four samples each. Each 

set contained two samples spiked with 1.0 ppm analytical grade ethephon (while the samples 

were still fresh) and two unspiked samples (one used as a control and the other as an analytical 

method spike). One set was analyzed prior to storage, providing zero-time data; the others were 

frozen at ·20 'C. 

Samples were removed from storage and analyzed at intervals of 1, 2, 4, and 6 months. The 

analytical method used was identical to the method discussed above (see AnalytkaI Method). 

Method validation results showed an average recovery of 90 ± II % for spikes of 0.05, 0.20, 

and 2.0 ppm over 3 days. The demonstrated limit of detection was 0.05 ppm. Results of the 

analysis are presented in Table 1. The data indicate that levels of ethephon do not significantly 

decrease over a 6 month period in cottonseed. 

• Table 1 Storage Stability Analysis' , Percent Recoveries 

Storage 

Stabmty Method Sample 

(months) Control Spike Sample I Sample 1 Avg. 

0 NDt 92 82 93 87.5 

I NO 108 82 91 86.5 

2 NO 108 82 91 86.S 

4 NO 108 93 76 84.5 

6 NO 96 90 76 83.5 

t Not Dotected. 

CBTS conclodes that the storage stability studies are not adequate for the purposes of this 

tolemoce request. The residue data submitted was generated after storage intervals of 208·350 

days, longer than the -180 day interval shown in the storage stability studies. Given the small 

number of spiked samples analyzed (10 total), CBTS is reluctant to extrapolate the existing data 

to cover a 12·month storage period. Therefore, the petitioner must submit storage stability data 

reflecting the storage times of the samples which were used to generate the residue data. Also, 

no data has been submitted concerning the stability of possible MCAA residues in cottonseed. 

Tests for MCAA residues were conducted 225·309 days after harvest. The petitioner must 

submit storage stability data for MCAA over a similar period of time. 

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Magnitude of the Residue - Field Study 

The petitioner submitted the study 'PREP/Cotton/Residues" (1990; MRID# 41704501). In this 

study, data was collected from 18 aerial application tests (conducted in AR, AZ, GA, MS, OK 

[two each), CA, and TX [four each)) and 20 ground application tests (conducted in Alt, AZ, 

CA, GA, NM, OK [two each), MS, and TX [four each)). The pesticide used was Prep (6 Ib 

ailgal EC formulation). These states account for approximately 84% of the 1988 U.S. 

cottonseed production (Alnicultural Statistics, 1989, p. 108) and thus represent adequate 

geographical representation. 

At each site, two treatment schemes were tested. The first scheme involved application at a rate 

of 0.5 Ib ail A followed 4 days later by 1.5 lb ail A; the second consisted of a single application 

at 2.0 lb ai/A. In almost all trials the first application was at approximately 50% boll opening • 

Spray volumes for aerial applications ranged from 1.98 - 5.4 gail A using commercially equipped 

fixed-wing aircraft or helicopter. Spray volumes for ground applications ranged from 11.5-20 

gail A using commercial sprayers or Co, backpaok sprayers. Both volumes used are consistent 

with the label directions (2-5 gal/acre aerial. 15-50 gal/acre ground applications - for only one 

ground application trial did the volume fall below 15 gal/A). 

Mature cottonseeds were harvested 7, 10-11, and 14 days following treatment. Samples from 

one harvest interval at five locations were air.-.dried 1()"24 hOUTS, and samples from one harvest 

interval at three locations were air-dried 2.5-4 hours before entering cold storage; samples from 

one harvest interval at two locations underwent additional air drying upon receipt at Rb6nePoulenc. Samples were stored on-site for intervals of 1-81 days at temperatures ranging from 

o ·C to -26 ·c, and were packed in dry ice for shipping via either overnight express or 

refrigerated truck; in transit time ranged from 1-34 days. laboratory storage was ,.-15 ·C. 

Total storage intervals ranged from 208-350 days between harvest and sample extJ:action and 1-9 

days between extJ:action and quantification for ethephon. 

Three replicate treated samples and one untreated control were collected from ~h site, 

generating a total of 342 samples and 57 controls which were tested for ethephon residues. 

Residue values were corrected for recovery efficiency (as determined by recovery of a 0.2 ppm 

spiked sample, analyzed separately. Average recovery was 85.0 ± 12.0%). A summary ofthe 

test data is presented in Table 2. 

Generally, the magnitude of the residues obtained from ground application was higher than that 

from aerial applications (although the difference is not statistically significant due to the large 

range of the residue values), There was no significant difference in the magnitude of residues 

found in crops harvested at different PIDs. 

Seven samples from two different trials contaln ethephon residue levels above the current 2 ppm 

tolerance, ranging as high as 3.6 ppm. The data are consistent, however, with the proposed 

tolerance of 4 ppm. 

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Table 2. Summary of Results of Ethephon Analysis 

pm Rate Applieatlon Residue Residue 

(day.) Obs aliA) Method Avg. (ppm) Range (ppm) 

7 0.5 + 1.5 aerial .24 ± .24 .02 - .83 

ground .64 ± .51 .ll - 2.0 

2.0 aerial .32 ± .26 .02 - 1.0 

groond .69 ± .70 .05 - 2.9 

1()'11 0.5 + 1.5 aerial .33 ± .33 .02 - 1.4 

ground .53 ± .51 .04 - 1.6 

2.0 aerial .35 ± .39 .02 - 1.5 

ground .60 ±.64 .04 - 2.7 

14 0.5 + 1.5 aerial .24 ± .30 .02 - .96 

groond .61 ± .79 .02 - 3.6 

2.0 aerial .37 ± .52 .02 - 2.0 

ground .55 ± .66 .02 - 2.4 

Cottonseed samples from four trial sites (AZ(2), MI, GAl were also analyzed for residues of 

monochloroacetic acid (MCAA). Two aerial and two ground application tests were run, with 

PHIs of 7, 10-11, and 14 days. Pre-analysis sample storage conditions were identical to those 

for the samples analyzed for ethephon (storage intervals ranged from 225-309 days). The test 

results showed application of ethephon did not cause any apparent increase in MCAA residues. 

Average detected levels were reported as 0.0053 ± .0029 ppm for control samples and 0.0056 

± .0034 ppm for treated samples (both values corrected for recoveries, see Analytical 

Methods). Reported residue levels in treated samples were not seositive to the method of 

application or PHI. 

CBTS is not convinced of the reported precision of the apparent MCAA residue levels. The 

demonstrated limit of detection is 0.01 ppm. No standard curves were submitted that would 

allow evaluation of the appropriateness of reporting MCAA residues at the ppl! level. However, 

evaluation of the submitted chromatograms shows that the relative amounts of apparent MCAA 

residues can be determined, and based on this data, MCAA residues in cottonseed are not 

enhanced by the application of ethephon. 

[We note that there are problems with the rule concerning the regulation of MCAA (21 CFR 

§ 189 .155). Subsection (a) states, in part, "(MCAA 1 is a synthrtic chentical not found in naturn! 

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products ... " and subsection (b) states 'Food containing any added or detectable level of 

monochloroacetic acid is deemed to be adulterated ... '. However, the submitted data indicates 

that MCAA residues could occur naturally in RAC's. The cottonseed results are reinforced by 

the data on MCAA residues in blackberries and cantaloupes which were submitted in connection 

with the 1988 Ethephon Guidance Document (MRID# 41668205 and 41668207). In these 

studies, naturally occurring low « 10 ppb) levels of apparent MCAA residues were also 

found. It is likely that this rule reflects the capability of the analytical methods at the time it 

was written, when MCAA residues below 10 ppb could not be detected. Further studies 

(GClMS, for example) could now be done to determine the identity of the compounds that elute 

at the MCAA retention time. For the purpose of this petition, such studies are not necessary. 

However, they may be necessary in the future, and at that point the suitability of 21 CFR 

§189.155 will need to be evaluated.] 

Pending submission of adequate storage stability data, CBTS concludes that the submitted data 

support the proposed amended tolerance of 4 ppm for ethephon on cottonseed. Also, application 

of ethephon to cottonseed does not result in an increase of monochloroacetic acid residues above 

naturally occurring levels. 

Magnitude or the Residue - Processing Study 

No data concerning the concentration of ethephon residues upon processing of cottonseed are 

submitted with this petition. However, two studies have been submitted previously by Union 

carbide Agricultural Products Company. 

In the first (1978; MRID# 00030190), cottonseed was harvested 6-21 days after a single 

application of ethephon at 2 Ib ai/A at sites in NM(!), OK(I), and TX(2), among others. 

Observed ethephon residues in these samples ranged from 0.03 - 1.4 ppm. Control values 

ranged from <0.01 ppm, the implied limit of detection, to 0.07 ppm. Replicate samples were 

composited prior to testing. Samples were analyzed using an adequate GC method, with 

demonstrated recoveries of 70-108% for 0.10 ppm forrified samples. Portions of the cottonseed 

samples from these trials were processed into hulls, meal, crude oil, refined oil, and soapstock. 

The results of these tests are summarized in Table 3. 

These data are intetpreted in the 2113/91 Update to signify that ethephon residues concentrated 

in cottonseed meal (6<) and refined oil (2x) and did not concentrate in hulls, crude oil, and 

soapstock. However, upon further consideration CBTS considers this conclusion incorrect. 

There is reason to be suspicious of the NM and TX(2) trial results, as the cottonseed samples 

bore residues within the range of residues found in the control samples. Since determination of 

the concentration factor involves dividing by this uncertain and smull number, unreliable and 

large concentration factors are likely to result. Furthermore, it is theoretically impossible for 

residues to concentrate in both meal and oil, as they represent the two main components of 

cottonseed. Since ethephon is highly water-soluble, and is claimed to be unstable in base, one 

would expect any concentration to occur in the meal. But, if the oil com:>rises approximately 

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Table 3~ Concentration of ethephon residues on processed cotton products. 

!Values represent Ill!m ethOlihon residuW 

NM OK TX(I) TX(2) 

Cottonseed 0.03 1.4 0.15 0.03 .-. --_._-._-_._-

Hulls 0.02 0.8 0.03 <0.01 

(Conc. Factor) (0.67) (0.57) (0.20) (-) 

Meal 0.18 1.29 0.18 0.19 

(Conc. Factor) (6.0) (0.9) (1.2) (6.3) 

Crude Oil <0.01 <0.01 <0.01 0.02 

(Conc. Factor) (-) ( -) (-) (0.67) 

Refmed Oil 0.06 0.05 0.01 0.04 

(Conc. Factor) (2.0) (0.0) (0.1) (1.3) 

Soapstock <0.03 <0.03 <0.03 <0.03 

(Conc. Factor) (-) (-) (-) (-) 

113 of the cottonseed (see N. K. Whetzel memo of 12/27179 in the Cotton C.P. File), the 

maximum possible residue concentration in the meal is 1.5x, not 6x as indicated above. CBTS 

considers the data generated by the OK and TX(l) trials, in which there is a finite amount of 

residues in the non~processed samples, as more likely to show the potential for concentration. 

We must conclude that this study indicates no concentration of residues in oil, and concentration 

of 1. 2x in cottonseed meal. 

In the other study (1977; MRlD# 00122423), six cottonseed samples from a site in CA were 

processed into meal and oil fractions. The samples had been harvested 7-14 days after treatment 

with 41b aiJA ethephon. Apparent residues on ",itreated samples ranged from <0.01 ppm, the 

implied limit of detection, to 0.08 ppm. Samples were analyzed using an adequate GC method, 

with demonstrated recoveries of 67-100% for 0.20 ppm fortified samples. Samples were stored 

at -35 'C for 108-167 days before analysis. The residue data is summarized in Table 4. 

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Table 4. Concentration of ethephon residues on processed cotton products. 

fYalues IeJ)resent Woo eihepbpn residues) 

PHI Cotton- Relined 

(00») - Meal Oil 

"{ 0.29 0.20 <O.O! 

0.18 0.08 • 

0.16 0.13 • 

14 0.09 0.10 • 

0.08 0.08 • 

0.15 0.Q7 • 

No residue concentration is observed for refined oil samples. The maximum residue 

concentration observed for meal samples is 1.1x. 

CBTS concludes that upon processing ethephon residues do not concentrate in oil but do 

concentrate in meal. Therefore, foodlfeed additive tolerances are not required for ethephon on 

refined oil or soap>tock. The petitioner should subntit a revised Section F requesting a foodlfced 

additive tolerance of 1.2Sx (S ppm) for residues of ethephon in cottonseed meal and deleting the 

FAT's for refined oil and soapstock. 

Meat, Milk, Poultry, and Eggs 

Tolerances of 0.1 ppm have been established for residues of ethephon in the fat, meat, and meat 

by-products of cattle, hogs, horses. and sheep, and in milk (40 CPR §180.300). No tolerances 

have been established for ethephon residues in poUltry tissues and or eggs. 

A high level feeding study for ethephon has been submitted previously (see R. Loranger memo 

of 6118/82, concerning EPA Reg. No. 264-267, located in the correspondence file of 

PPKOF2312). Levels of S, 15, SO, and ISO ppm ethephon in the diet were fed for 28 

consecutive day. to 3 cows at each level. No detectable residues « 0.02 ppm) were found in 

meat for the IS and SO ppm feeding levels. The 150 ppm level feeding study did not result in 

residues in heart, muscle, fat, or kidney. One liver sample showed 0.2 ppm ethephon. The 150 

ppm feeding level did result in trace residues in milk. Five of fifteen samples contained residues 

ranging from 0.10 to 0.14 ppm ethephon, five contained detectable levels « 0.05 ppm), and 

five contained no detectable levels « 0.02 ppm). 

A poultry feeding study was summarized in the ethephon reregistration standard (memo of 

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4/19/88). CmcJren. were fed for 28 days at 2S or 50 ppm ethephon. Breast, gizzard, liver, 

thigh tissues, and egg. were analyzed from the 50 ppm group. Fat tissue was analyzed from the 

25 ppm dosed group. These residues were reported: eggs, <0.01 ppm: breast, <0.01-0.04 

ppm: liver, <0.01-0.03 ppm: gizzard, 0.02 ppm: thigh tissue, <0.01 ppm: and fat, <0.01 

ppm. 

No tolerances have been established in poUltry tissue or eggs. Since cottonseed products 

constitute a small portion (S 10%) of poultry feed, and there is already a registration for 

ethephon on cotton we have no objection to allowing thai any changes in the existing tolerances 

be addressed in the reregistration process. 

Other Considerations 

There are no Codex, Canadian, or Mexican tolerances for ethephon established inion RAC 

cottonseed or processed cottonseed products. Therefore, there are no compatibility problems 

expected for this petition. 

Attachment: Codex sheet. 

cc: RF, FAPNIH5603, SF, Ethephon Registration Standanl File, R. Schmitt, R. 

Lascola, Cire. (7), C. Furlow (PffiIFOD), L. Rossi (H7S08W). 

RDI: P.V. Errico (11120/91), R. Loranger (11120/91) 

H7509C:CBTS:CM#2, Room 803C, 557-1478, R. LascoIa:7/24/91 

IIJ:Disk2\ETHEPH0N\E5603.TXT 

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