1 APPENDIX B.

T

- REX Example Output and Parameterization

I. Example T

- REX Input (Citrus: 2 x 0.133 lb ai/A, 7

- d interval, DT50 = 12.3 days)

II. Derivation of Sulfoxaflor Foliar Dissipation Half Life

For deriving a sulfoxaflor

- specific foliar dissipation rate , a n abundance of residue

- decline data was

available from registrant

- submitted field residue trials (MRID 48755703). In selecting data sets for

calculating the foliar dissipation half life values, guidelines provided in the T

- REX User’s Gu ide was

followed. 1 Specifically, residue

- decline data sets needed to meet the following criteria in order to be

considered for half life calculation:

1. Day 0 measurement of residues available

2. At least 3 measurement times with residues above the limit of det ection

3. R 2 values (ln concentration vs. time) of 0.7 or higher

4. Statistical significance of regression coefficient of 0.1 or lower

Based on these criteria, a total of 44 foliar DT

50 values were available for sulfoxaflor

Individual DT50 values for sulfoxaflor measured in various crops and crop matrices ( Table B

- 1 ). These

DT 50 values consisted of measurements on a variety of crops and plant matrices ( e.g ., foliage, fruit,

seeds, grains and roots. In situations were multiple trials were available wit hin a crop and crop matrix

( e.g ., multiple values for head lettuce), the DT

50 values were averaged. The resulting 25 DT

50 values

averaged within a crop matrix are shown in Table B

- 2

.

1 http://www.epa.gov/oppefed1/models/terrestrial/trex/t_rex_user_guide.htm Avian

Endpoint Toxicity value Indicate test species p

Organism Body Optional Test Species Name

LD50 (mg/kg-bw) 80.00 3 Must Enter >>

12.00 zebra finch

LC50 (mg/kg-diet) 5620.00 2

NOAEL (mg/kg-bw) 26.00 2

NOAEC (mg/kg-diet)

200.00 2

1.15

Mammalian

Acute Study Chronic Study

350 350

Endpoint Toxicity value Reference (MRID)

LD50 (mg/kg-bw) 1000.00

LC50 (mg/kg-diet)

Reported Chronic

Endpoint 100.00

2

Is estimated daily dose

(mg/kg-bw) reported from

the available chronic

mammal study? (yes or no) yes

Enter daily dose (mg/kg-bw) 6.07 Enter the Mineau et al. Scaling Factor

Size (g) of mammal used in toxicity study

mg/kg-diet Other

Mallard duck

Mallard duck

Mallard duck2 Table B

- 1. Individual foliar DT50 values for sulfoxaflor (source: MRID 48755703)

DT50

(days) Cumulative

Percentile Crop Matrix DAS Study

ID Trial ID

1.5 2% Leaf Lettuce Leaves 80073 80504

1.8 4% Mustard Greens Leaves 90129 Trial 1

1.9 7% Leaf Lettuce Leaves 101453 CEMS

- 4690A

2 9% Head Lettuce Head 90101 90721

2.1 11% Radish Tops 90016 Trial 2

2.2 13% Head Lettuce Head 101625 4691A

2.3 16% Cabbage Heads 80074 80511

2.3 18% Cabbage Heads 80074 80511

2.4 20% Leaf Lettuce Leaves 080032

- 04 CEMS

- 3939A

2.4 22% Leaf Lettuce Leaves 080032

- 04 CEMS

- 3939A

2.5 24% Wheat Forage 80152 Trial 2

2.7 27% Head Lettuce Head 080032

- 02 3942A

2.7 29% Head Lettuce Head 080032

- 02 3942A

2.9 31% Cauliflower Inflorescence 90104 90735

2.9 33% Cauliflower Inflorescence 90104 90735

3 36% Head Lettuce Head 080032

- 02 3942C

3.1 38% Canola Forage 08008B 80594

3.2 40% Broccoli Head/Stems 80074 80509

3.2 42% Broccoli Head/Stems 80074 80509

3.2 44% Broccoli Head/Stems 80074 80509

3.3 47% Barley Straw 80087 80588

3.3 49% Barley Straw 80087 80588

3.8 51% Barley Forage 80087 80588

3.8 53% Barley Forage 80087 80588

4.3 56% Canola Forage 90109 90763

4.8 58% Radish Roots 90016 Trial 2

5.1 60% Spinach Foliage 80013 Trial 2

5.4 62% Wheat Straw 80086 80580

6.3 64% Melon Fruit 080041

- 02 3965B

6.4 67% Canola Seed 101630 CEMS

- 4713A

6.4 69% Canola Seed 101630 CEMS

- 4713A

6.6 71% Tomato Fruit 80014 2

7.1 73% Strawberry Berries 80026 Trial 1

7.1 76% Strawberry Berries 80026 Trial 1

7.7 78% Barley Grain 80087 80588

8 80% Pepper Fruit 90103 90731

8.8 82% Strawberry Berries 80089 80577

10.2 84% Orange Peel 80093 Trial BR13 11.4 87% Apricot Fruit 80085 80566

12.8 89% Tomato Fruit 90095 2

23.3 91% Orange Fruit 80079 80531

30.2 93% Orange Fruit 90035 90741

32.4 96% Orange Fruit 80079 80531

40.9 98% Wheat Straw 80086 80583

Table B

- 2. Mean DT50 values for sulfoxaflor measured with various crops and crop matrices

DT50

(days) r/n+1 Crop Matrix DAS

Study

ID Trial ID

1.8 4% Mustard

Greens Leaves 90129 Trial 1

2.1 8% Radish Tops 90016 Trial 2

2.3 12% Cabbage Heads 80074 80511

2.4 15% Head Lettuce Head 90101 90721

2.46 19% Leaf Lettuce Leaves 80073 80504

2.9 23% Cauliflower Inflorescence 90104 90735

2.9 27% Wheat Forage 80086 80580

3.2 31% Broccoli Head/Stems 80074 80509

3.3 35% Barley Straw 80087 80588

3.5 38% Wheat Hay 80152 Trial 1

3.7 42% Canola Forage 08008B 80594

3.8 46% Barley Forage 80087 80588

4 50% Spinach Foliage 90102 90726

4.8 54% Radish Roots 90016 Trial 2

5.2 58% Pepper Fruit 90103 90731

6.3 62% Melon Fruit 080041

-

02 3965B

6.4 65% Canola Seed 101630 CEMS

4713A

7.1 69% Wheat Grain 80086 80580

7.233333 73% Tomato Fruit 80076 80519

7.7 77% Barley Grain 80087 80588

7.95 81% Strawberry Berries 80089 80577

10.2 85% Orange Peel 80093 Trial BR1

11.4 88% Apricot Fruit 80085 80566

23.15 92% Wheat Straw 80086 80580

28.63333 96% Orange Fruit 80079 805314 III. Example T

- REX Input Parameters

IV. Example T

- REX Output

Table B

- 3. Upper Bound Kenaga, Acute Avian Dose

- Based Risk Quotients

Size

Class

(grams) Adjusted

LD50

(mg/kg) EECs (mg/kg bw/d) and RQs

Short Grass Tall Grass Broadleaf Plants Fruits/

Pods/Seeds Arthropods Granivore

EEC RQ EEC RQ EEC RQ EEC RQ EEC RQ EEC RQ

20 > 86.37 60.9 <0.7 27.9 <0.32 34.2 <0.40 3.8 < 0.04 23.8 <0.28 0.85 0.01

100 > 109.95 34.7 <0.32 15.9 <0.14 19.5 <0.18 2.2 < 0.02 13.6 <0.12 0.48 < 0.0 1

1000 > 155.31 15.5 <0.10 7.1 < 0.05 8.7 < 0.06 1.0 < 0.01 6.1 < 0.04 0.22 <0.01

Table B

- 4 . Upper Bound Kenaga, Subacute Avian Dietary Based Risk Quotients

LC50

(ppm) EECs (ppm diet) and RQs

Short Grass Tall Grass Broadleaf

Plants Fruits/Pods/S

eeds Arthropods

EEC RQ EEC RQ EEC RQ EEC RQ EEC RQ

5620 53.44 0.01 24.49 < 0.0 1 30.06 0.01 3.34 <0.01 20.93 <0.01

Size class not used for dietary risk quotients Avian

Endpoint Toxicity value Indicate test species p

Organism Body Optional Test Species Name

LD50 (mg/kg-bw) 80.00 3 Must Enter >>

12.00 zebra finch

LC50 (mg/kg-diet) 5620.00 2

NOAEL (mg/kg-bw) 26.00 2

NOAEC (mg/kg-diet)

200.00 2

1.15

Mammalian

Acute Study Chronic Study

350 350

Endpoint Toxicity value Reference (MRID)

LD50 (mg/kg-bw) 1000.00

LC50 (mg/kg-diet)

Reported Chronic

Endpoint 100.00

2

Is estimated daily dose

(mg/kg-bw) reported from

the available chronic

mammal study? (yes or no) yes

Enter daily dose (mg/kg-bw) 6.07 Enter the Mineau et al. Scaling Factor

Size (g) of mammal used in toxicity study

mg/kg-diet Other

Mallard duck

Mallard duck

Mallard duck5 Table B

- 5 . Upper Bound Kenaga, Chronic Avian Dietary Based Risk Quotients

NOAEC

(ppm) EECs (ppm diet) and RQs

Short Grass Tall Grass Broadleaf

Plants Fruits/Pods/S

eeds Arthropods

EEC RQ EEC RQ EEC RQ EEC RQ EEC RQ

200 53.44 0.27 24.49 0.12 30.06 0.15 3.34 0.02 20.93 0.10

Size class not used for dietary risk quotients

Table B

- 6 . Upper Bound Kenaga, Acute Mammalian Dose

- Based Risk Quotients

Size

Class

(g) Adjusted

LD50

(mg/kg) EECs (mg/kg bw/d) and RQs

Short Grass Tall Grass Broadleaf

Plants Fruits/Pods/

Seeds Arthropods Granivore

EEC RQ EEC RQ EEC RQ EEC RQ EEC RQ EEC RQ

15 2198 5 1

. 0 0.02 23. 4 0.01 28.7 0.01 3.18 <0.01 20.0 <0.01 0.7 1 <0.01

35 1778 35.2 0.02 16.1 0.01 19.8 0.01 2.20 <0.01 13. 8 <0.01 0.4 9 <0.01

1000 769 8.16 0.01 3.74 <0.01 4.59 0.01 0.51 <0.01 3. 20 <0.01 0.11 <0.01

Table B

- 7 . Upper Bound Kenaga, Chronic Mammalian Dietary Based Risk Quotients

NOAEC

(ppm) EECs (mg/kg

- bw/d) and RQs

Short Grass Tall Grass Broadleaf

Plants Fruits/Pods/

Seeds/Large

Insects Arthropods

EEC RQ EEC RQ EEC RQ EEC RQ EEC RQ

100 53.44 0.53 24.49 0.24 30.06 0.30 3.34 0.03 20.93 0.21

Size class not used for dietary risk quotients

Table B

- 8. Upper Bound Kenaga, Chronic Mammalian Dose Based Risk Quotients

Size

Class

(g) Adjusted

NOAEL

(mg/kg/d) EECs (mg/kg/d) and RQs

Short

Grass Tall Grass Broadleaf

Plants Fruits/Pods/

Seeds Arthropods Granivore

EEC RQ EEC RQ EEC RQ EEC RQ EEC RQ EEC RQ

15 13.34 50.9 3.8 23.4 1.8 28.7 2.1 3.2 0.24 20.0 1.5 0.71 0.05

35 10.79 35.2 3.3 16.1 1.5 19.8 1.8 2.2 0.20 13.8 1.3 0.49 0.05

1000 4.67 8.2 1.7 3.7 0.80 4.6 0.98 0.51 0.11 3.2 0.68 0.11 0.02