<PAGE>

                                                                    EXHIBIT 10.9

                         EXECUTIVE EMPLOYMENT AGREEMENT

                       ASPREVA PHARMACEUTICALS CORPORATION

PRIVATE AND CONFIDENTIAL

                                                                January 28, 2002

Noel Hall
5077 Cordova Bay Road
Victoria, B.C.
V8Y 2K1

Dear Mr. Hall:

RE:   TERMS OF EMPLOYMENT WITH ASPREVA PHARMACEUTICALS CORPORATION (THE
      "CORPORATION")

      This Agreement confirms the terms and conditions of your employment by the
Corporation and will constitute your employment agreement. Those terms and
conditions are set out below:

1.    Position and Duties. You will be employed by and will serve the
      Corporation as its President having the duties and functions described in
      SCHEDULE A attached to this Agreement. You will report directly to the
      Chief Executive Officer of the Corporation. Your duties and functions
      pertain to the Corporation and any of its subsidiaries from time to time
      and may be varied or added to from time to time by the Chief Executive
      Officer or the Board of Directors (the "Board"), at their discretion,
      exercised reasonably.

2.    Term. The terms and conditions of this Agreement shall have effect as of
      and from January 28, 2002 (the "EFFECTIVE DATE") and your employment as
      President of the Corporation shall continue until terminated as provided
      in this Agreement.

3.    Base Salary. The Corporation shall pay you a base salary at the rate of
      CDN $200,000 per year (the "BASE SALARY"), payable semi-monthly, subject
      to the withholding of all applicable statutory deductions from such Base
      Salary in respect of the Base Salary and including any taxable benefits
      received under this Agreement or in respect of your employment. The
      Corporation shall have no obligation to pay to you, nor shall any Base
      Salary accrue to you pursuant to this Agreement until the Corporation has
      completed offerings of its equity securities raising aggregate gross
      proceeds of at least $2 million.

4.    Annual Review. The compensation committee established by the Board for the
      purposes of this Agreement (the "COMPENSATION COMMITTEE") shall review
      your Base Salary annually. This review shall not result in a decrease of
      your Base Salary nor shall it necessarily result in an increase in your
      Base Salary and any increase shall be in the discretion of the Board.

<PAGE>

                                      -2-

5.    Performance Bonus. The Corporation shall review the performance of your
      duties and functions under this Agreement annually and shall pay you a
      cash bonus of up to 35% of your Base Salary if the Board, in its sole
      discretion determines that the Corporation has met its short-term and
      long-term business performance objectives (together, the "OBJECTIVES"),
      which Objectives will be established from time to time by the Board or the
      Compensation Committee in consultation with you. Payment of the
      performance bonus set out in this Section 5 shall be made to you within a
      reasonable time following the end of each fiscal year and shall be subject
      to the withholding of all applicable statutory deductions by the
      Corporation.

6.    Benefits. The Corporation will arrange for you to be provided with health,
      medical, dental, disability, accident and life insurance and such other
      benefits as are reasonable and appropriate for an executive level benefits
      plan, as determined by the Board from time to time, based on the
      recommendations of the Compensation Committee, in consultation with you.
      You may be required to provide information and undergo reasonable
      assessments of the insurers in order to determine your eligibility for
      benefits coverage. Please note that coverage under any benefit plan in
      effect from time to time is subject to availability and other requirements
      of the applicable insurer.

7.    Vacation. During your employment with the Corporation under this
      Agreement, you will be entitled to an annual paid vacation as determined
      by the Corporation from time to time, not less than 5 weeks per annum. The
      Corporation reserves the right, acting reasonably, to request that
      vacations be scheduled so as not to conflict with critical business
      operations.

8.    Reimbursement for Expenses. During your employment under this Agreement,
      the Corporation shall reimburse you for reasonable travelling and other
      expenses actually and properly incurred by you in connection with the
      performance of your duties and functions, such reimbursement to be made in
      accordance with, and subject to, the policies of the Corporation from time
      to time. For all such expenses you will be required to keep proper
      accounts and to furnish statements, vouchers, invoices and/or other
      supporting documents to the Corporation within 30 days after the date the
      expenses are incurred.

9.    Stock Options. You will be eligible to receive stock options pursuant to
      the Aspreva 2002 Incentive Stock Option Plan. Any stock options granted to
      you shall be in such numbers and upon such terms as the Board or the
      Compensation Committee may determine in its discretion, as the case may
      be.

10.   Compliance with Insider Trading Guidelines and Restrictions. As a result
      of your position as President, you are subject to insider trading
      regulations and restrictions and are required to file insider reports
      disclosing the grant of any options as well as the purchase and sale of
      any shares in the capital of the Corporation. The Corporation may from
      time to time publish trading guidelines and restrictions for its
      employees, officers and directors as are considered by the Board, in its
      discretion, prudent and necessary for a publicly listed company. It is a
      term of your employment as a senior officer of the Corporation that you
      comply with such guidelines and restrictions.

<PAGE>

                                      -3-

11.   Directors' & Officers' Liability Insurance. The Corporation shall use
      commercially reasonable efforts to provide you with directors' and
      officers' liability insurance under the policies for such insurance
      arranged by the Corporation from time to time upon such terms and in such
      amounts as the Board may reasonably determine in its discretion..

12.   No Other Compensation or Benefits. You expressly acknowledge and agree
      that unless otherwise expressly agreed in writing by the Corporation
      subsequent to execution of this Agreement by the parties hereto, you shall
      not be entitled by reason of your employment by the Corporation or by
      reason of any termination of such employment, to any remuneration,
      compensation or benefits other than as expressly set forth in this
      Agreement.

13.   Service to Employer. During your employment under this Agreement you will:

      (a)   well and faithfully serve the Corporation, at all times act in, and
            promote, the best interests of the Corporation, and devote
            substantially the whole of your working time, attention and energies
            to the business and affairs of the Corporation;

      (b)   comply with all rules, regulations, policies and procedures of the
            Corporation; and

      (c)   not, without the prior approval of the Board, carry on or engage in
            any other business or occupation or become a director, officer,
            employee or agent of or hold any position or office with any other
            corporation, firm or person, except as a volunteer for a non-profit
            organization, for personal investments or a personal holding
            company, which may include members of your family as shareholders.

14.   Termination By Executive

      (a)   Subject to Section 17 (Termination Following Change in Control), you
            may resign as President of the Corporation at any time, but only by
            giving the Corporation at least 3 months' prior written notice of
            the effective date of your resignation. On the giving of any such
            notice, the Corporation shall have the right to elect, in lieu of
            the notice period, to pay you a lump sum equal to 3 months' Base
            Salary, as referred to in Section 3 (Base Salary) and as adjusted
            from time to time in accordance with Section 4 (Annual Review), plus
            other sums owed for arrears of salary, vacation pay and, if granted
            pursuant to Section 5 (Performance Bonus), bonus.

      (b)   If the Corporation elects to pay you such lump sum in lieu of the 3
            months' notice period, the Corporation shall, subject to the terms
            and conditions of any benefit plans in effect from time to time,
            maintain the benefits and payments set out in Section 6 (Benefits)
            of this Agreement for 3 months after the date of your notice, but in
            all other respects, your resignation and the termination of your
            employment will be effective immediately upon your receipt of the
            lump sum.

<PAGE>

                                      -4-

15.   Termination by the Corporation Without Cause.

      (a)   The Corporation may terminate your employment as President of the
            Corporation at any time without Cause (as defined below) by giving
            you written notice of the effective date of such termination and in
            all respects, except as set out below, the termination of your
            employment will be effective immediately.

      (b)   If your employment is terminated by the Corporation pursuant to this
            Section, the Corporation shall pay to you as a lump sum the number
            of months of Base Salary, as referred to in Section 3 (Base Salary)
            and as adjusted from time to time in accordance with Section 4
            (Annual Review), set out in the table below depending upon the year
            of employment in which you are terminated, plus such other sums owed
            for arrears of salary, vacation pay and, if granted pursuant to
            Section 5 (Performance Bonus), bonus:

<TABLE>
<CAPTION>
Year of Employment      Lump Sum Payment of Base Salary (as adjusted)
------------------      ---------------------------------------------
<S>                     <C>
1 - 2                   6 months

3 - 5                   12 months

6 and over              12 months, plus one additional month for each full year
                        of employment over 5 years, up to a maximum of 18 months
                        in aggregate
</TABLE>

      (c)   To the extent permitted by law and subject to the terms and
            conditions of any benefit plans in effect from time to time, the
            Corporation shall maintain the benefits and payments set out in
            Section 6 (Benefits) of this Agreement (the "MAINTENANCE PAYMENTS")
            during the notice period.

      (d)   Notwithstanding Section 15(c), if you obtain a new source of
            remuneration for personal services, whether through an office, new
            employment, a contract for you to provide consulting or other
            personal services, or any position analogous to any of the
            foregoing, the Maintenance Payments shall terminate 6 months from
            the date of termination of your employment (excluding the notice
            period).

      (e)   The payments of Base Salary and benefits set out in this Section 15
            shall be in lieu of any applicable notice period.

      (f)   In addition, the Corporation will arrange for you to be provided
            with such outplacement career counselling services as are reasonable
            and appropriate, to assist you in seeking new executive level
            employment.

      (g)   You shall not be required to mitigate the amount of any payment
            provided for in this Section 15 by seeking other employment or
            otherwise, nor will any sums actually received be deducted.

      (h)   The obligation of the Corporation to pay any amount or to provide
            any benefit to your pursuant to this Section shall be subject to you
            resigning as a director of the

<PAGE>

                                      -5-

            Corporation, unless you are entitled to be a director of the
            Corporation pursuant to an agreement among the shareholders of the
            Corporation.

16.   Termination by the Corporation for Cause. Notwithstanding Section 14
      (Termination by Executive), Section 15 (Termination by the Corporation
      Without Cause), or Section 17 (Termination Following Change of Control),
      the Corporation may terminate your employment as President and require
      that you resign as a director of the Corporation (unless you are otherwise
      entitled to act as a director of the Corporation pursuant to an agreement
      among the Shareholders of the Corporation) for Cause at any time without
      any notice or severance. In this Agreement, "CAUSE" shall include, but not
      be limited to, the following:

      (a)   the commission of theft, embezzlement, fraud, obtaining funds or
            property under false pretences or similar acts of misconduct with
            respect to the property of the Corporation or its employees or the
            Corporation's customers or suppliers;

      (b)   your entering of a guilty plea or conviction for any crime involving
            fraud, misrepresentation or breach of trust, or for any serious
            criminal offence that impacts adversely on the Corporation; or

      (c)   any other matter constituting just cause at common law.

            any of which shall entitle the Corporation to terminate your
            employment under this Section 16.

17.   Termination Following Change in Control. Concurrently with execution and
      delivery of this Agreement, you and the Corporation shall enter into a
      "Change of Control Agreement" in the form attached hereto as Schedule B
      setting out the compensation provisions to be applicable in the event of
      the termination of your employment as President of the Corporation in
      certain circumstances following a "Change in Control" of the Corporation
      (as defined in the Change of Control Agreement).

18.   No Additional Compensation upon Termination. It is agreed that neither you
      nor the Corporation shall, as a result of the termination of your
      employment, be entitled to any notice, fee, salary, bonus, severance or
      other payments, benefits or damages arising by virtue of, or in any way
      relating to, your employment or any other relationship with the
      Corporation (including termination of such employment or relationship) in
      excess of what is specified or provided for in Section 14 (Termination by
      Executive), Section 15 (Termination by the Corporation Without Cause),
      Section 16 (Termination by the Corporation for Cause), or Section 17
      (Termination Following Chance in Control), whichever is applicable.
      Payment of any amount whatsoever pursuant to Section 14 (Termination by
      Executive), Section 15 (Termination by the Corporation Without Cause),
      Section 16 (Termination by the Corporation for Cause), or Section 17
      (Termination Following Change in Control) shall be subject to the
      withholding of all applicable statutory deductions by the Corporation.

<PAGE>

                                      -6-

19.   Confidentiality and Assignment of Inventions. Concurrently with execution
      and delivery of this Agreement and in consideration of your employment by
      the Corporation, you and the Corporation will enter into a
      "Confidentiality Agreement and Assignment of Inventions" in the form
      attached hereto as SCHEDULE C.

20.   Disclosure of Conflicts of Interest. During your employment with the
      Corporation, you will promptly, fully and frankly disclose to the
      Corporation in writing:

      (a)   the nature and extent of any interest you or your Associates (as
            hereinafter defined) have or may have, directly or indirectly, in
            any contract or transaction or proposed contract or transaction of
            or with the Corporation or any subsidiary or affiliate of the
            Corporation;

      (b)   every office you may hold or acquire, and every property you or your
            Associates may possess or acquire, whereby directly or indirectly a
            duty or interest might be created in conflict with the interests of
            the Corporation or your duties and obligations under this Agreement;
            and

      (c)   the nature and extent of any conflict referred to in subsection (b)
            above.

      In this Agreement the expression "ASSOCIATE" shall include all those
      persons and entities that are included within the definition or meaning of
      "associate" as set forth in Section 1(1) of the Company Act (British
      Columbia), as amended, or any successor legislation of similar force and
      effect, and shall also include your spouse, children, parents, brothers
      and sisters.

21.   Avoidance of Conflicts of Interest. You acknowledge that it is the policy
      of the Corporation that all interests and conflicts of the sort described
      in Section 20 (Disclosure of Conflicts of Interest) be avoided, and you
      agree to comply with all policies and directives of the Board from time to
      time regulating, restricting or prohibiting circumstances giving rise to
      interests or conflicts of the sort described in Section 20 (Disclosure of
      Conflicts of Interest). During your employment with the Corporation,
      without Board approval, in its sole discretion, you shall not enter into
      any agreement, arrangement or understanding with any other person or
      entity that would in any way conflict or interfere with this Agreement or
      your duties or obligations under this Agreement or that would otherwise
      prevent you from performing your obligations hereunder, and you represent
      and warrant that you or your Associates have not entered into any such
      agreement, arrangement or understanding.

22.   Provisions Reasonable. It is acknowledged and agreed that:

      (a)   both before and since the Effective Date the Corporation has
            operated and competed and will operate and compete in a global
            market, with respect to the business of the Corporation set out in
            SCHEDULE D attached hereto (the "BUSINESS");

      (b)   competitors of the Corporation and the Business are located in
            countries around the world;

<PAGE>

                                      -7-

      (c)   in order to protect the Corporation adequately, any enjoinder of
            competition would have to apply world wide;

      (d)   during the course of your employment by the Corporation, both before
            and after the Effective Date, on behalf of the Corporation, you have
            acquired and will acquire knowledge of, and you have come into
            contact with, initiated and established relationships with and will
            come into contact with, initiate and establish relationships with,
            both existing and new clients, customers, suppliers, principals,
            contacts and prospects of the Corporation, and that in some
            circumstances you have been or may well become the senior or sole
            representative of the Corporation dealing with such persons; and

      (e)   in light of the foregoing, the provisions of Section 23 (Restrictive
            Covenant) below are reasonable and necessary for the proper
            protection of the business, property and goodwill of the Corporation
            and the Business.

23.   Restrictive Covenant. Subject to the exceptions set out in Schedule E
      attached hereto, you agree that you will not, either alone or in
      partnership or in conjunction with any person, firm, company, corporation,
      syndicate, association or any other entity or group, whether as principal,
      agent, employee, director, officer, shareholder, consultant or in any
      capacity or manner whatsoever, whether directly or indirectly, for the
      Term of Employment and continuing for a period of 6 months from the lawful
      termination of your employment, regardless of the reason for such
      termination:

      (a)   carry on or be engaged in, concerned with or interested in, or
            advise, invest in or give financial assistance to, any business,
            enterprise or undertaking that:

            (i)   is involved in the Business or in the sale, distribution,
                  development or supply of any product or service that is
                  competitive with the Business or any product or service of the
                  Business; or

            (ii)  competes with the Corporation with respect to any aspect of
                  the Business;

            provided, however, that the foregoing will not prohibit you from
            acquiring, solely as an investment and through market purchases,
            securities of any such enterprise or undertaking which are publicly
            traded, so long as you are not part of any control group of such
            entity and such securities, which if converted, do not constitute
            more than 5% of the outstanding voting power of that entity;

      (b)   solicit, agree to be employed by, or agree to provide services to
            any person, firm, corporation or other entity that was a client,
            customer, supplier, principal, shareholder, investor, collaborator,
            strategic partner, licensee, contact or prospect of the Corporation
            during the time of your employment with the Corporation, whether
            before or after the Effective Date, for any business purpose that is
            competitive with the Business or any product or service of the
            Business; or

<PAGE>

                                      -8-

      (c)   divert, entice or take away from the Corporation or attempt to do so
            or solicit for the purpose of doing so, any business of the
            Corporation, or any person, firm, corporation or other entity that
            was an employee, client, customer, supplier, principal, shareholder,
            investor, collaborator, strategic partner, licensee, contact or
            prospect of the Corporation during the time of your employment with
            the Corporation, whether before or after the Effective Date.

24.   Remedies. You acknowledge and agree that any breach or threatened breach
      of any of the provisions of Section 10 (Compliance with Insider Trading
      and Guidelines and Restrictions), Section 13 (Service to Employer),
      Section 19 (Confidentiality and Assignment of Inventions), Section 20
      (Disclosure of Conflicts of Interest), Section 21 (Avoidance of Conflicts
      of Interest) or Section 23 (Restrictive Covenant) could cause irreparable
      damage to the Corporation or its partners, subsidiaries or affiliates,
      that such harm could not be adequately compensated by the Corporation's
      recovery of monetary damages, and that in the event of a breach or
      threatened breach thereof, the Corporation shall have the right to seek an
      injunction, specific performance or other equitable relief as well as any
      equitable accounting of all your profits or benefits arising out of any
      such breach. It is further acknowledged and agreed that the remedies of
      the Corporation specified in this Section 24 are in addition to and not in
      substitution for any rights or remedies of the Corporation at law or in
      equity and that all such rights and remedies are cumulative and not
      alternative and that the Corporation may have recourse to any one or more
      of its available rights or remedies as it shall see fit.

25.   Binding Effect. This Agreement shall be binding upon and inure to the
      benefit of the Corporation and its successors and assigns. Your rights and
      obligations contained in this Agreement are personal and such rights,
      benefits and obligations shall not be voluntarily or involuntarily
      assigned, alienated or transferred, whether by operation of law or
      otherwise, without the prior written consent of the Corporation. This
      Agreement shall otherwise be binding upon and inure to the benefit of your
      personal or legal representatives, executors, administrators, successors,
      heirs, distributees, devisees, legatees and permitted assigns.

26.   Agreement Confidential. Both parties shall keep the terms and conditions
      of this Agreement confidential except as may be required to enforce any
      provision of this Agreement or as may otherwise be required by any law,
      regulation or other regulatory requirement.

27.   Governing Law. This Agreement shall be governed by and interpreted in
      accordance with the laws of the Province of British Columbia and
      applicable laws of Canada and the parties hereto attorn to the exclusive
      jurisdiction of the provincial and federal courts of such province.

28.   Exercise of Functions. The rights of the Corporation as provided in this
      Agreement may be exercised on behalf of the Corporation only by the Board
      (excluding you).

29.   Entire Agreement. The terms and conditions of this Agreement are in
      addition to and not in substitution for the obligations, duties and
      responsibilities imposed by law on

<PAGE>

                                      -9-

      employees of corporations generally, and you agree to comply with such
      obligations, duties and responsibilities. Except as otherwise provided in
      this Agreement, this Agreement constitutes the entire agreement between
      the parties with respect to the subject matter hereof, and may only be
      varied by further written agreement signed by you and the Corporation.
      This Agreement supersedes any previous communications, understandings and
      agreements between you and the Corporation regarding your employment. It
      is acknowledged and agreed that this Agreement is mutually beneficial and
      is entered into for fresh and valuable consideration with the intent that
      it shall constitute a legally binding agreement.

30.   Further Assurances. The parties will execute and deliver to each other
      such further instruments and assurances and do such further acts as may be
      required to give effect to this Agreement.

31.   Surviving Obligations. Your obligations and covenants under Section 19
      (Confidentiality and Assignment of Inventions), Section 23 (Restrictive
      Covenant) and Section 24 (Remedies) shall survive the termination of this
      Agreement.

32.   Independent Legal Advice. You hereby acknowledge that you have obtained or
      have had an opportunity to obtain independent legal advice in connection
      with this Agreement, and further acknowledge that you have read,
      understand, and agree to be bound by all of the terms and conditions
      contained herein.

33.   Notice. Any notice or other communication required or contemplated under
      this Agreement to be given by one party to the other shall be delivered or
      mailed by prepaid registered post to the party to receive same at the
      address as set out below:

            IF TO THE CORPORATION:

            Aspreva Pharmaceuticals Corporation
            c/o Farris Vaughan Wills & Murphy
            26th Floor, 700 West Georgia Street
            Vancouver, BC  V7Y 1B3

            Attention: R. Hector MacKay-Dunn

            IF TO NOEL HALL:

            Noel Hall
            5077 Cordova Bay Road
            Victoria, BC  V8Y 2K1

            Any notice delivered shall be deemed to have been given and received
            on the first business day following the date of delivery. Any notice
            mailed shall be deemed to have been given and received on the fifth
            business day following the date it was posted, unless between the
            time of mailing and actual receipt of the notice there shall be a
            mail strike, slow-down or other labour dispute which might affect

<PAGE>

                                      -10-

            delivery of the notice by mail, then the notice shall be effective
            only if actually delivered.

34.   Severability. If any provision of this Agreement or any part thereof shall
      for any reason be held to be invalid or unenforceable in any respect, then
      such invalid or unenforceable provision or part shall be severable and
      severed from this Agreement and the other provisions of this Agreement
      shall remain in effect and be construed as if such invalid or
      unenforceable provision or part had never been contained herein.

35.   Waiver. Any waiver of any breach or default under this Agreement shall
      only be effective if in writing signed by the party against whom the
      waiver is sought to be enforced, and no waiver shall be implied by any
      other act or conduct or by any indulgence, delay or omission. Any waiver
      shall only apply to the specific matter waived and only in the specific
      instance in which it is waived.

36.   Counterparts. This Agreement may be executed in any number of
      counterparts, each of which so executed shall be deemed to be an original,
      and such counterparts will together constitute but one Agreement.

If you accept and agree to the foregoing, please confirm your acceptance and
agreement by signing the enclosed duplicate copy of this letter where indicated
below and by returning it to us. You are urged to consider fully all the above
terms and conditions and to obtain independent legal advice or any other advice
you feel is necessary before you execute this agreement.

                                            Yours truly,

                                            ASPREVA PHARMACEUTICALS CORPORATION

                                            By: /s/ RICHARD M. GLICKMAN
                                                --------------------------------
                                                Authorized Signatory

Accepted and agreed to by Noel Hall as of the 28th day of January, 2002

/s/ NOEL HALL
----------------
NOEL HALL

<PAGE>

                                   SCHEDULE A
                     DESCRIPTION OF THE DUTIES AND FUNCTIONS
                                OF THE PRESIDENT

-     participate in the formulation of long-range strategic plans and the
      setting of goals and objectives;

-     participate in policy and executive direction of the Corporation;

-     analyze operating results in the light of goals and objectives and assist
      management team in taking corrective action, when required;

-     direct commercialization team for drug assessment;

-     direct marketing team for rare disease therapeutic product sales;

-     assist management team ensuring expenditures are in accordance with
      approved budgets and that adequate funding is maintained;

-     assist management team planning human resource development to ensure
      continuity of the Corporation's operations;

-     assist management team hiring or developing a strong team of second tier
      managers;

-     assist management team building organization (e.g. facilities, personnel,
      contract research organizations, collaboration, strategic alliances, etc.)
      to successfully carry out the operation business plan.

-     strengthen the business development department in line with the
      Corporation's need to develop attractive partnerships or joint ventures;

-     create a stimulating environment which empowers and inspires employees to
      achieve corporate goals;

-     represent the Corporation in the business and non-business community and
      nurture relationships with associates and partners;

-     keep the Chief Executive Officer apprised of corporate developments and
      activities such as:

          -     performance compared to the operational business plan;

          -     economic, industry and business matters that may impact the
                Corporation; and

          -     other matters of relevance.

-     such other duties as may be requested by the Chief Executive Officer from
      time to time.

<PAGE>

                                   SCHEDULE B

                       ASPREVA PHARMACEUTICALS CORPORATION

                                                                JANUARY 28, 2002

Noel Hall
5077 Cordova Bay Road
Victoria, B.C.
V8Y 2K1

Dear Mr. Hall:

                        RE: CHANGE IN CONTROL AGREEMENT

            Aspreva Pharmaceuticals Corporation (the "Corporation") considers it
essential to the best interests of its members to foster the continuous
employment of its senior executive officers. In this regard, the Board of
Directors of the Corporation (the "Board") has determined that it is in the best
interests of the Corporation and its members that appropriate steps should be
taken to reinforce and encourage management's continued attention, dedication
and availability to the Corporation in the event of a Potential Change in
Control (as defined in Section 2), without being distracted by the uncertainties
which can arise from any possible changes in control of the Corporation.

            In order to induce you to agree to remain in the employ of the
Corporation, such agreement evidenced by the employment agreement entered into
as of the date of this Agreement between you and the Corporation (the
"Employment Agreement") and in consideration of your agreement as set forth in
Section 3 below, the Corporation agrees that you shall receive and you agree to
accept the severance and other benefits set forth in this Agreement should your
employment with the Corporation be terminated subsequent to a Change in Control
(as defined in Section 2) in full satisfaction of any and all claims that now
exist or then may exist for remuneration, fees, salary, bonuses or severance
arising out of or in connection with your employment by the Corporation or the
termination of your employment:

1.    TERM OF AGREEMENT.

            This Agreement shall be in effect for a term commencing on the
Effective Date of the Employment Agreement (as therein defined) and ending on
the date of termination of the Employment Agreement.

2.    DEFINITIONS.

      (a)   "Affiliate" means a corporation that is an affiliate of the
            Corporation under the Securities Act (British Columbia), as amended
            from time to time.

      (b)   "Change in Control" of the Corporation shall be deemed to have
            occurred:

<PAGE>

                                      -2-

            (i)   if a merger, amalgamation, arrangement, consolidation,
                  reorganization or transfer takes place in which Equity
                  Securities of the Corporation possessing more than 50% of the
                  total combined voting power of the Corporation's outstanding
                  Equity Securities are acquired by a person or persons
                  different from the persons holding those Equity Securities
                  immediately prior to such transaction, and the composition of
                  the Board following such transaction is such that the
                  directors of the Corporation prior to the transaction
                  constitute less than 50% of the Board membership following the
                  transaction, except that no Change in Control will be deemed
                  to occur if such merger, amalgamation, arrangement,
                  consolidation, reorganization or transfer is with any
                  subsidiary or subsidiaries of the Corporation;

            (ii)  if any person, or any combination of persons acting jointly or
                  in concert by virtue of an agreement, arrangement, commitment
                  or understanding shall acquire or hold, directly or
                  indirectly, 50% or more of the voting rights attached to all
                  outstanding Equity Securities; or

            (iii) if any person, or any combination of persons acting jointly or
                  in concert by virtue of an agreement, arrangement, commitment
                  or understanding shall acquire or hold, directly or
                  indirectly, the right to appoint a majority of the directors
                  of the Corporation; or

            (iv)  if the Corporation sells, transfers or otherwise disposes of
                  all or substantially all of its assets, except that no Change
                  of Control will be deemed to occur if such sale or disposition
                  is made to a subsidiary or subsidiaries of the Corporation.

            provided however, that a Change in Control shall not be deemed to
            have occurred if such Change in Control results solely from the
            issuance, in connection with a bona fide financing or series of
            financings by the Corporation of Equity Securities.

      (c)   "Base Salary" shall mean the annual base salary, as referred to in
            Section 3 (Base Salary), and as adjusted from time to time in
            accordance with Section 4 (Annual Review), of the Employment
            Agreement.

      (d)   "Bonus" shall mean the bonus referred to in Section 5 (Performance
            Bonus) of the Employment Agreement.

      (e)   "Cause" shall have the meaning set out in Section 16 (Termination by
            the Corporation for Cause) of the Employment Agreement.

      (f)   "Date of Termination" shall mean, if your employment is terminated,
            the date specified in the Notice of Termination.

<PAGE>

                                      -3-

      (g)   "Equity Security" in respect of a security of the Corporation, shall
            have the meaning ascribed thereto in Part II of the Securities Act
            (British Columbia), as it existed on the date of this Agreement, and
            also means any security carrying the right to convert such security
            into, exchange such security for, or entitling the holder to
            subscribe for, any equity security, or into or for any such
            convertible or exchangeable security or security carrying a
            subscription right.

      (h)   "Good Reason" shall mean the occurrence of one or more of the
            following events, without your express written consent, within 12
            months of Change in Control:

            (i)   a material change in your status, position, authority or
                  responsibilities that does not represent a promotion from or
                  represents an adverse change from your status, position,
                  authority or responsibilities in effect immediately prior to
                  the Change in Control;

            (ii)  a material reduction by the Corporation, in the aggregate, in
                  your Base Salary, or incentive, retirement, health benefits,
                  bonus or other compensation plans provided to you immediately
                  prior to the Change in Control, unless an equitable
                  arrangement has been made with respect to such benefits in
                  connection with a Change in Control;

            (iii) a failure by the Corporation to continue in effect any other
                  compensation plan in which you participated immediately prior
                  to the Change in Control (except for reasons of
                  non-insurability), including but not limited to, incentive,
                  retirement and health benefits, unless an equitable
                  arrangement has been made with respect to such benefits in
                  connection with a Change in Control;

            (iv)  any request by the Corporation or any affiliate of the
                  Corporation that you participate in an unlawful act; or

            (v)   any purported termination of your employment by the
                  Corporation after a Change in Control which is not effected
                  pursuant to a Notice of Termination satisfying the
                  requirements of clause (i) below and for the purposes of this
                  Agreement, no such purported termination shall be effective.

      (i)   "Notice of Termination" shall mean a notice, in writing,
            communicated to the other party in accordance with Section 6 below,
            which shall indicate the specific termination provision in this
            Agreement relied upon and shall set forth in reasonable detail the
            facts and circumstances claimed to provide a basis for termination
            of your employment under the provision so indicated.

      (j)   "Potential Change in Control" of the Corporation shall be deemed to
            have occurred if:

<PAGE>

                                      -4-

            (i)   the Corporation enters into an agreement, the consummation of
                  which would result in the occurrence of a Change in Control;

            (ii)  any person (including the Corporation) publicly announces an
                  intention to take or to consider taking actions which if
                  consummated would constitute a Change in Control; or

            (iii) the Board adopts a resolution to the effect that, for the
                  purposes of this Agreement, a Potential Change in Control of
                  the Corporation has occurred.

3.    POTENTIAL CHANGE IN CONTROL.

            You agree that, in the event of a Potential Change in Control of the
Corporation occurring after the Effective Date, and until 12 months after a
Change in Control, subject to your right to terminate your employment by issuing
and delivering a Notice of Termination for Good Reason, you will continue to
diligently carry out your duties and obligations, on the terms set out in the
Employment Agreement.

4.    COMPENSATION UPON TERMINATION FOLLOWING CHANGE IN CONTROL.

            Subject to compliance by you with Section 3, upon your employment
terminating pursuant to a Notice of Termination within 12 months after a Change
in Control, the Corporation agrees that you shall receive and you agree to
accept, subject to your prior resignation as a director of the Corporation, the
following payments in full satisfaction of any and all claims you may have or
then may have against the Corporation, for remuneration, fees, salary, benefits,
bonuses or severance, arising out of or in connection with your employment by
the Corporation or the termination of your employment:

      (a)   If your employment shall be terminated by the Corporation for Cause
            or by you other than for Good Reason, the terms of the Employment
            Agreement shall govern and the Corporation shall have no further
            obligations to you under this Agreement.

      (b)   If your employment by the Corporation shall be terminated by you for
            Good Reason or by the Corporation other than for Cause, then you
            shall be entitled to the payments and benefits provided below:

            (i)   subject to the withholding of all applicable statutory
                  deductions, the Corporation shall pay you a lump sum equal to
                  12 months' Base Salary, as referred to in Section 3 (Base
                  Salary) and as adjusted from time to time in accordance with
                  Section 4 (Annual Review) of the Employment Agreement, plus
                  other sums owed for arrears of salary, vacation pay and, if
                  awarded, Bonus;

            (ii)  to the extent permitted by law and subject to the terms and
                  conditions of any benefit plans in effect from time to time,
                  the Corporation shall

<PAGE>

                                      -5-

                  maintain the benefits and payments set out in Section 6
                  (Benefits) of the Employment Agreement during the 12 month
                  period;

            (iii) the Corporation shall arrange for you to be provided with such
                  outplacement career counselling services as are reasonable and
                  appropriate, to assist you in seeking new executive level
                  employment; and

            (iv)  all incentive stock options granted to you by the Corporation
                  under any stock option agreement that is entered into between
                  you and the Corporation and is outstanding at the time of
                  termination of your employment, which incentive stock options
                  have not yet vested, shall immediately vest upon the
                  termination of your employment and shall be fully exercisable
                  by you in accordance with the terms of the agreement or
                  agreements under which such options were granted.

You shall not be required to mitigate the amount of any payment provided for in
this Section 4 by seeking other employment or otherwise, nor will any sums
actually received be deducted.

5.    BINDING AGREEMENT.

            This Agreement shall enure to the benefit of and be enforceable by
your personal or legal representatives, executors, administrators, successors,
heirs, distributees, devisees and legatees. If you die while any amount would
still be payable to you under this Agreement if you had continued to live, that
amount shall be paid in accordance with the terms of this Agreement to your
devisee, legatee or other designee or, if there is no such designee, to your
estate.

6.    NOTICES.

            Any notice or other communication required or contemplated under,
this Agreement to be given by one party to the other shall be delivered or
mailed by prepaid registered post to the party to receive same at the addresses
set out below:

            IF TO ASPREVA PHARMACEUTICALS CORPORATION:

            Aspreva Pharmaceuticals Corporation
            c/o Farris, Vaughan, Wills & Murphy
            26th Floor, 700 West Georgia Street
            Vancouver, BC  V7Y 1B3

            Attn:    R. Hector MacKay-Dunn

            IF TO NOEL HALL:

            Noel Hall
            5077 Cordova Bay Road
            Victoria, BC  V8Y 2K1

<PAGE>

                                      -6-

Any notice delivered shall be deemed to have been given and received on the
first business day following the date of delivery. Any notice mailed shall be
deemed to have been given and received on the fifth business day following the
date it was posted, unless between the time of mailing and actual receipt of the
notice there shall be a mail strike, slow-down or other labour dispute which
might affect delivery of the notice by mail. In such event, the notice shall be
effective only if actually delivered.

7.    MODIFICATION: AMENDMENTS: ENTIRE AGREEMENT.

            This Agreement may not be modified, waived or discharged unless such
waiver, modification or discharge is agreed to in writing and signed by you and
such officer as may be specifically designated by the Board. No waiver by either
party at any time of any breach by the other party of, or compliance with, any
condition or provision of this Agreement to be performed by such other party
will be deemed a waiver of similar or dissimilar provisions or conditions at the
same or at any prior or subsequent time. Except as set forth in your Employment
Agreement, no agreements or representations, oral or otherwise, express or
implied, with respect to the subject matter hereof have been made by either
party which are not expressly set forth in this Agreement.

8.    GOVERNING LAW.

            This Agreement shall be governed by and interpreted in accordance
with the laws of the Province of British Columbia and applicable laws of Canada
and the parties hereto attorn to the exclusive jurisdiction of the provincial
and federal courts of such province.

9.    VALIDITY.

            The invalidity or unenforceability of any provision of this
Agreement shall not affect the validity or enforceability of any other provision
of this Agreement, which shall remain in full force and effect.

10.   NO EMPLOYMENT OR SERVICE CONTRACT

            Nothing in this Agreement shall confer upon you any right to
continue in the employment of the Corporation for any period of specific
duration or interfere with or otherwise restrict in any way the rights of the
Corporation or you, which rights are hereby expressly reserved by each, to
terminate your employment at any time for any reason whatsoever, with or without
cause.

<PAGE>

                                      -7-

            If the foregoing sets forth our agreement on this matter, kindly
sign and return to the Corporation a copy of this letter.

                                                Yours truly,

                                                ASPREVA PHARMACEUTICALS
                                                CORPORATION

                                                By: /s/ RICHARD M. GLICKMAN
                                                    ---------------------------
                                                    Authorized Signatory

Accepted and agreed to by Noel Hall, as of the 28th day of January, 2002

/s/ NOEL HALL
--------------
NOEL HALL

<PAGE>

                                   SCHEDULE C

                          CONFIDENTIALITY AGREEMENT AND
                            ASSIGNMENT OF INVENTIONS

                       ASPREVA PHARMACEUTICALS CORPORATION

PRIVATE AND CONFIDENTIAL

                                                                January 28, 2002

Noel Hall
5077 Cordova Bay Road
Victoria, B.C.
V8Y 2K1

Dear Mr. Hall:

The purpose of this letter is to confirm and record the terms of the agreement
(the "AGREEMENT") between you and Aspreva Pharmaceuticals Corporation
("ASPREVA") concerning the terms on which you will (i) receive from and disclose
to Aspreva proprietary and confidential information; (ii) agree to keep the
information confidential, to protect it from disclosure and to use it only in
accordance with the terms of this Agreement; and (iii) assign to Aspreva all
rights, including any ownership interest which may arise in all inventions and
intellectual property developed or disclosed by you over the course of your work
during your employment with Aspreva. The effective date ("EFFECTIVE DATE") of
this Agreement is the date that you start or started working at Aspreva, as
indicated in the employment agreement between you and Aspreva dated as of
January 28, 2002.

In consideration of the offer of employment by Aspreva and the payment by
Aspreva to you of the sum of CDN$1.00 and other good and valuable consideration,
the receipt and sufficiency of which is hereby acknowledged, you and Aspreva
hereby agree as follows:

1.    INTERPRETATION

1.1   DEFINITIONS. In this Agreement:

      (a)   "CONFIDENTIAL INFORMATION", subject to the exemptions set out in
            Section 2.8, shall mean any information relating to Aspreva's
            Business (as hereinafter defined), whether or not conceived,
            originated, discovered, or developed in whole or in part by you,
            that is not generally known to the public or to other persons who
            are not bound by obligations of confidentiality and:

<PAGE>

                                      -2-

            (i)   from which Aspreva derives economic value, actual or
                  potential, from the information not being generally known; or

            (ii)  in respect of which Aspreva otherwise has a legitimate
                  interest in maintaining secrecy;

            and which, without limiting the generality of the foregoing, shall
            include;

            (iii) all proprietary information licensed to, acquired, used or
                  developed by Aspreva in its search and development activities
                  including but not restricted to the development and
                  commercialization of drugs for rare diseases and conditions
                  and orphan drugs as defined by the U.S. Orphan Drug Act, other
                  scientific strategies and concepts, designs, know-how,
                  information, material, formulas, processes, research data and
                  proprietary rights in the nature of copyrights, patents,
                  trademarks, licenses and industrial designs;

            (iv)  all information relating to Aspreva's Business, and to all
                  other aspects of Aspreva's structure, personnel, and
                  operations, including financial, clinical, regulatory,
                  marketing, advertising and commercial information and
                  strategies, customer lists, compilations, agreements and
                  contractual records and correspondence; programs, devices,
                  concepts, inventions, designs, methods, processes, data,
                  know-how, unique combinations of separate items that is not
                  generally known and items provided or disclosed to Aspreva by
                  third parties subject to restrictions on use or disclosure;

            (v)   all know-how relating to Aspreva's Business including, all
                  biological, chemical, pharmacological, toxicological,
                  pharmaceutical, physical and analytical, clinical, safety,
                  manufacturing and quality control data and information, and
                  all applications, registrations, licenses, authorizations,
                  approvals and correspondence submitted to regulatory
                  authorities;

            (vi)  all information relating to the businesses of competitors of
                  Aspreva including information relating to competitors'
                  research and development, intellectual property, operations,
                  financial, clinical, regulatory, marketing, advertising and
                  commercial strategies, that is not generally known;

            (vii) all information provided by Aspreva's agents, consultants,
                  lawyers, contractors, licensors or licensees to Aspreva and
                  relating to Aspreva's Business; and

            (viii) all information relating to your compensation and benefits,
                  including your salary, vacation, stock options, rights to
                  continuing education, perquisites, severance notice, rights on
                  termination and all other compensation and benefits, except
                  that you shall be entitled to disclose such information to
                  your bankers, advisors, agents, consultants and other third
                  parties who

<PAGE>

                                      -3-

                  have a duty of confidence to you and who have a need to know
                  such information in order to provide advice, products or
                  services to you.

      (b)   "INVENTIONS" shall mean any and all discoveries, developments,
            enhancements, improvements, concepts, formulas, processes, ideas,
            writings, whether or not reduced to practice, industrial and other
            designs, patents, patent applications, provisional patent
            applications, continuations, continuations-in-part, substitutions,
            divisionals, reissues, renewals, re-examinations, extensions,
            supplementary protection certificates or the like, trade secrets or
            utility models, copyrights and other forms of intellectual property
            including all applications, registrations and related foreign
            applications filed and registrations granted thereon.

      (c)   "WORK PRODUCT" shall mean any and all Inventions and possible
            Inventions relating to Aspreva's Business resulting from any work
            performed by you for Aspreva that you may invent or co-invent during
            your involvement in any capacity with Aspreva, except those
            Inventions invented by you entirely on your own time that do not
            relate to Aspreva's Business or do not derive from any equipment,
            supplies, facilities, Confidential Information or other information,
            gained, directly or indirectly, by you from or through your
            involvement in any capacity with Aspreva.

      (d)   "ASPREVA'S BUSINESS" shall mean the businesses actually carried on
            by Aspreva, directly or indirectly, whether under an agreement with
            or in collaboration with, any other party including but not
            exclusively, the development and commercialization of drugs for rare
            diseases and conditions and orphan drugs as defined by the U.S.
            Orphan Drug Act.

2.    CONFIDENTIALITY

2.1   BASIC OBLIGATION OF CONFIDENTIALITY. You hereby acknowledge and agree that
in the course of your involvement with Aspreva, Aspreva may disclose to you or
you may otherwise have access or be exposed to Confidential Information. Aspreva
hereby agrees to provide such access to you and you agree to receive and hold
all Confidential Information on the terms and conditions set out in this
Agreement. Except as set out in this Agreement, you will keep strictly
confidential all Confidential Information and all other information belonging to
Aspreva that you acquire, observe or are informed of, directly or indirectly, in
connection with your involvement, in any capacity, with Aspreva.

2.2   FIDUCIARY CAPACITY. You will be and act toward Aspreva as a fiduciary in
respect of the Confidential Information.

2.3   NON-DISCLOSURE. Unless Aspreva first gives you written permission to do so
under Section 2.7 of this Agreement, you will not at any time, either during or
after your involvement in any capacity with Aspreva;

      (a)   use or copy Confidential Information or your recollections thereof;

<PAGE>

                                      -4-

      (b)   publish or disclose Confidential Information or your recollections
            thereof to any person other than to employees of Aspreva who have a
            need to know such Confidential Information for their work for
            Aspreva;

      (c)   permit or cause any Confidential Information to be used, copied,
            published, disclosed, translated or adapted except as otherwise
            expressly permitted by this Agreement;

      (d)   permit or cause any Confidential Information to be stored off the
            premises of Aspreva, including permitting or causing such
            Information to be stored in electronic format on personal computers,
            except in accordance with written procedures of Aspreva, as amended
            from time to time in writing; or

      (e)   communicate the Confidential Information or your recollections
            thereof to another employee of Aspreva in a public place or using
            methods of communication that are capable of being intercepted (such
            as unencrypted messages using the internet or cellular phones) or
            overheard, without the written permission of Aspreva.

2.4   TAKING PRECAUTIONS. You will take all reasonable precautions necessary or
prudent to prevent material in your possession or control that contains or
refers to Confidential Information from being discovered, used or copied by
third parties.

2.5   ASPREVA'S OWNERSHIP OF CONFIDENTIAL INFORMATION. As between you and
Aspreva, Aspreva shall own all right, title and interest in and to the
Confidential Information, whether or not created or developed by you.

2.6   CONTROL OF CONFIDENTIAL INFORMATION AND RETURN OF INFORMATION. All
physical materials produced or prepared by you containing Confidential
Information, including, without limitation, biological material, chemical
entities, test results, notes of experiments, computer files, photographs, x-ray
film, designs, devices, formulas, memoranda, drawings, plans, prototypes,
samples, accounts, reports, financial statements, estimates and materials
prepared in the course of your responsibilities to or for the benefit of
Aspreva, shall belong to Aspreva, and you will promptly turn over to Aspreva's
possession every original and copy of any and all such items in your possession
or control upon request by Aspreva. You shall not permit or cause any physical
materials to be stored off the premises of Aspreva, unless in accordance with
written procedures of Aspreva, as amended from time to time in writing. You
shall not transfer any biological material to another person outside of Aspreva,
unless a material transfer agreement has been signed by both Aspreva and the
other party. You shall not accept any biological material from another person
outside of Aspreva, unless in accordance with written procedures of Aspreva, as
amended from time to time in writing.

2.7   PURPOSE OF USE. You will use Confidential Information only for purposes
authorised or directed by Aspreva.

2.8   EXEMPTIONS. Your obligation of confidentiality under this Agreement will
not apply to any of the following:

<PAGE>

                                      -5-

      (a)   information that is already known to you, though not due to a prior
            disclosure by Aspreva or by a person who obtained knowledge of the
            information, directly or indirectly, from Aspreva;

      (b)   information disclosed to you by another person who is not obliged to
            maintain the confidentiality of that information and who did not
            obtain knowledge of the information, directly or indirectly, from
            Aspreva;

      (c)   information that is developed by you independently of Confidential
            Information received from Aspreva and such independent development
            can be documented by you;

      (d)   other particular information or material which Aspreva expressly
            exempts by written instrument signed by Aspreva;

      (e)   information or material that is in the public domain through no
            fault of your own; and

      (f)   information or material that you are obligated by law to disclose,
            to the extent of such obligation, provided that:

            (i)   in the event that you are required to disclose such
                  information or material, then, as soon as you become aware of
                  this obligation to disclose, you will provide Aspreva with
                  prompt written notice so that Aspreva may seek a protective
                  order or other appropriate remedy and/or waive compliance with
                  the provisions of this Agreement;

            (ii)  if Aspreva agrees that the disclosure is required by law, it
                  will give you written authorization to disclose the
                  information for the required purposes only;

            (iii) if Aspreva does not agree that the disclosure is required by
                  law, this Agreement will continue to apply, except to the
                  extent that a Court of competent jurisdiction orders
                  otherwise; and

            (iv)  if a protective order or other remedy is not obtained or if
                  compliance with this Agreement is waived, you will furnish
                  only that portion of the Confidential Information that is
                  legally required and will exercise all reasonable efforts to
                  obtain confidential treatment of such Confidential
                  Information.

3.    ASSIGNMENT OF INTELLECTUAL PROPERTY RIGHTS

3.1   NOTICE OF INVENTION. You agree to promptly and fully inform Aspreva of all
your Work Product, whether or not patentable, throughout the course of your
involvement, in any capacity, with Aspreva, whether or not developed before or
after your execution of this Agreement. On your ceasing to be employed by
Aspreva for any reason whatsoever, you will

<PAGE>

                                      -6-

immediately deliver up to Aspreva all of your Work Product. You further agree
that all of your Work Product shall at all times be the Confidential Information
of Aspreva.

3.2   ASSIGNMENT OF RIGHTS. Subject only to those exceptions set out in Exhibit
A hereto, you will assign, and do hereby assign, to Aspreva or, at the option of
Aspreva and upon notice from Aspreva, to Aspreva's designee, your entire right,
title and interest in and to all of your Work Product during your involvement,
in any capacity, with Aspreva and all other rights and interests of a
proprietary nature in and associated with your Work Product, including all
patents, patent applications filed and other registrations granted thereon. To
the extent that you retain or acquire legal title to any such rights and
interests, you hereby declare and confirm that such legal title is and will be
held by you only as trustee and agent for Aspreva. You agree that Aspreva's
rights hereunder shall attach to all of your Work Product, notwithstanding that
it may be perfected or reduced to specific form after you have terminated your
relationship with Aspreva. You further agree that Aspreva's rights hereunder are
worldwide rights and are not limited to Canada, but shall extend to every
country of the world.

3.3   MORAL RIGHTS. Without limiting the foregoing, you irrevocably waive any
and all moral rights arising under the Copyright Act (Canada), as amended, or
any successor legislation of similar force and effect or similar legislation in
other applicable jurisdictions or at common law that you may have with respect
to your Work Product, and agree never to assert any moral rights which you may
have in your Work Product, including, without limitation, the right to the
integrity of such Work Product, the right to be associated with the Work
Product, the right to restrain or claim damages for any distortion, mutilation
or other modification or enhancement of the Work Product and the right to
restrain the use or reproduction of the Work Product in any context and in
connection with any product, service, cause or institution, and you further
confirm that Aspreva may use or alter any such Work Product as Aspreva sees fits
in its absolute discretion.

3.4   GOODWILL. You hereby agree that all goodwill you have established or may
establish with clients, customers, suppliers, principals, shareholders,
investors, collaborators, strategic partners, licensees, contacts or prospects
of Aspreva relating to the business or affairs of Aspreva (or of its partners,
subsidiaries or affiliates), both before and after the Effective Date, shall, as
between you and Aspreva, be and remain the property of Aspreva exclusively, for
Aspreva to use, alter, vary, adapt and exploit as Aspreva shall determine in its
discretion.

3.5   ASSISTANCE. You hereby agree to reasonably assist Aspreva, at Aspreva's
request and expense, in:

      (a)   making patent applications for your Work Product, including
            instructions to lawyers and/or patent agents as to the
            characteristics of your Work Product in sufficient detail to enable
            the preparation of a suitable patent specification, to execute all
            formal documentation incidental to an application for letters patent
            and to execute assignment documents in favour of Aspreva for such
            applications;

      (b)   making applications for all other forms of intellectual property
            registration relating to your Work Product;

<PAGE>

                                      -7-

      (c)   prosecuting and maintaining the patent applications and other
            intellectual property relating to your Work Product; and

      (d)   registering, maintaining and enforcing the patents and other
            intellectual property registrations relating to your Work Product.

3.6   ASSISTANCE WITH PROCEEDINGS. You further agree to reasonably assist
Aspreva, at Aspreva's request and expense, in connection with any defence to an
allegation of infringement of another person's intellectual property rights,
claim of invalidity of another person's intellectual property rights, opposition
to, or intervention regarding, an application for letters patent, copyright or
trademark or other proceedings relating to intellectual property or applications
for registration thereof.

4.    GENERAL

4.1   TERM AND DURATION OF OBLIGATION. The term of this Agreement is from the
Effective Date and terminates on the date that you are no longer working at or
for Aspreva. Except as otherwise agreed in a written instrument signed by
Aspreva, Article 2 shall survive the termination of this Agreement, including
your obligations of confidentiality and to return Confidential Information, and
shall endure, with respect to each item of Confidential Information, for so long
as those items fall within the definition of Confidential Information. Sections
1.1, 3.2, 3.3, 3.4, 3.5, 3.6, 4.1, 4.2, 4.4, 4.5, 4.6, 4.7, 4.8, 4.9, 4.10,
4.11, 4.12 and 4.13 shall also survive the termination of this Agreement.

4.2   BINDING NATURE OF AGREEMENT. This Agreement is not assignable by you. You
agree that this Agreement shall be binding upon your heirs and estate.

4.3   NON-COMPETITION. While you are an employee of Aspreva, you will not
provide services to or enter into a contract of employment or service in any
capacity for any business which is in any way competitive with Aspreva's
Business without the prior written consent of Aspreva.

4.4   NO CONFLICTING OBLIGATIONS. You represent and warrant that you will not
use or disclose to other persons at Aspreva information that (i) constitutes a
trade secret of persons other than Aspreva during your employment at Aspreva, or
(ii) which is confidential information owned by another person. You represent
and warrant that you have no agreements with or obligations to others with
respect to the matters covered by this Agreement or concerning the Confidential
Information that are in conflict with anything in this Agreement.

4.5   EQUITABLE REMEDIES. You acknowledge and agree that a breach by you of any
of your obligations under this Agreement would result in damages to Aspreva that
could not be adequately compensated by monetary award. Accordingly, in the event
of any such breach by you, in addition to all other remedies available to
Aspreva at law or in equity, Aspreva shall be entitled as a matter of right to
apply to a court of competent jurisdiction for such relief by way of restraining
order, injunction, decree or otherwise, as may be appropriate to ensure
compliance with the provisions of this Agreement, without having to prove
damages to the court.

<PAGE>

                                      -8-

4.6   PUBLICITY. You shall not, without the prior written consent of Aspreva,
make or give any public announcements, press releases or statements to the
public or the press regarding your Work Product or any Confidential Information.

4.7   SEVERABILITY. If any covenant or provision of this Agreement or of a
section of this Agreement is determined by a court of competent jurisdiction to
be void or unenforceable in whole or in part, then such void or unenforceable
covenant or provision shall not affect or impair the enforceability or validity
of the balance of the section or any other covenant or provision.

4.8   TIME OF ESSENCE/NO WAIVER. Time is of the essence hereof and no waiver,
delay, indulgence, or failure to act by Aspreva regarding any particular default
or omission by you shall affect or impair any of Aspreva's rights or remedies
regarding that or any subsequent default or omission that is not expressly
waived in writing, and in all events time shall continue to be of the essence
without the necessity of specific reinstatement.

4.9   FURTHER ASSURANCES. The parties will execute and deliver to each other
such further instruments and assurances and do such further acts as may be
required to give effect to this Agreement.

4.10  NOTICES. All notices and other communications that are required or
permitted by this Agreement must be in writing and shall be hand delivered or
sent by express delivery service or certified or registered mail, postage
prepaid, or by facsimile transmission (with written confirmation copy by
registered first-class mail) to the parties at the addresses indicated below.

     IF TO ASPREVA:

     Aspreva Pharmaceuticals Corporation
     c/o Farris, Vaughan, Wills & Murphy
     26th Floor, 700 West Georgia Street
     Vancouver, BC  V7Y 1B3

     Attn: R. Hector MacKay-Dunn

     IF TO NOEL HALL:

     Noel Hall
     5077 Cordova Bay Road
     Victoria, BC  V8Y 2K1

Any such notice shall be deemed to have been received on the earlier of the date
actually received or the date five (5) days after the same was posted or sent.
Either party may change its address or its facsimile number by giving the other
party written notice, delivered in accordance with this Section 4.10.

4.11  AMENDMENT. No amendment, modification, supplement or other purported
alteration of this Agreement shall be binding unless it is in writing and signed
by you and by Aspreva.

<PAGE>

                                      -9-

4.12  ENTIRE AGREEMENT. This Agreement supersedes all previous dealings,
understandings, and expectations of the parties and constitutes the whole
agreement with respect to the matters contemplated hereby, and there are no
representations, warranties, conditions or collateral agreements between the
parties with respect to such transactions except as expressly set out herein.

4.13  GOVERNING LAW. This Agreement shall be governed by and interpreted in
accordance with the laws of the Province of British Columbia and applicable laws
of Canada and the parties hereto attorn to the exclusive jurisdiction of the
provincial and federal courts of such province.

4.14  INDEPENDENT LEGAL ADVICE. You hereby acknowledge that you have obtained or
have had an opportunity to obtain independent legal advice in connection with
this Agreement, and further acknowledge that you have read, understand, and
agree to be bound by all of the terms and conditions contained herein.

4.15  ACCEPTANCE

            If the foregoing terms and conditions are acceptable to you, please
indicate your acceptance of and agreement to the terms and conditions of this
Agreement by signing below on this letter and on the enclosed copy of this
letter in the space provided and by returning the enclosed copy so executed to
us. Your execution and delivery to Aspreva of the enclosed copy of this letter
will create a binding agreement between us.

Thank you for your cooperation in this matter.

Yours truly,

ASPREVA PHARMACEUTICALS CORPORATION

By: /s/ RICHARD M. GLICKMAN
    --------------------------------
        Authorized Signatory

Accepted and agreed as of the 28th day of January, 2002

                                             /s/ NOEL HALL
_______________________                      ---------------------------------
Witness Signature                            SIGNATURE OF NOEL HALL

_______________________
Witness Name

_______________________
Occupation

_______________________
Address

<PAGE>

                                    EXHIBIT A

                           EXCLUSION FROM WORK PRODUCT

                                      None

<PAGE>

                                   SCHEDULE D

                             BUSINESS OF THE COMPANY

The business of the Corporation shall mean the business actually carried on by
the Corporation, directly or indirectly, whether under an agreement with or in
collaboration with any other party including, but not limited to the development
and commercialization of drugs for rare diseases and conditions and orphan drugs
as defined by the U.S. Orphan Drug Act.

<PAGE>

                                   SCHEDULE E

                        EXCEPTION TO RESTRICTIVE COVENANT

                                      None