Initial to indicate certification as to information on this page (full text of certification is on page one). Date INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary. 2. Case # and Name 3. Date and Type of DCI and Number

4. EPA Product Registration 5. I wish to cancel this product registration voluntarily 6. Generic Data 7. Product Specific Data 6a. I am claiming a Generic Data Exemption because I obtain the active ingredient from the source EPA registration number listed below. 6b. I agree to satisfy Generic Data Requirements as indicated on the attached form entitled "Requirements Status and Registrant's Response." 7a. My product is an MUP and I agree to satisfy the MUP requirement on the attached form entitled "Requirements Status and Registrant's Response." 7b. My product is an EUP and I agree to satisfy the EUP requirement on the attached form entitled "Requirements Status and Registrant's Response." OMB Approval 2070-0174

1. Company Name and Address N/A - Phostebupirim Chemical # and Name: 129086 Phostebupirim 08-Sep-2010 GENERIC ID # GDCI-129086-930 

### United States Environmental Protection Agency

Washington, D.C. 20460 DATA CALL-IN RESPONSE 1 Page of 1

8. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law. Signature and Title of Company's Authorized Representative ______________________________________________________ 10. Name of Company N/A N/A

9. Date

11. Phone NumberInitial to indicate certification as to information on this page (full text of certification is on page one) 13. Phone Number 10. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law.
12. Name of Company 11. Date OMB Approval 2070-0174 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Signature and Title of Company's Authorized Representative _________________________________________________________________

Environmental Fate Data Requirements (Conventional Chemical)

Nontarget Plant Protection Data Requirements (Conventional Chemical) 835.1410 835.2240 835.2370 835.4100 835.4300

850.4100 850.4150 Laboratory volatilization from soil

Direct photolysis rate of parent and degradates in water Photodegradation of parent and degradates in air Aerobic soil metabolism Aerobic aquatic metabolism
Terrestrial Plant Toxicity (Seedling Emergence) Terrestrial plant toxicity, Tier 1 (vegetative vigor) N/A - Phostebupirim Chemical # and Name: 129086 Phostebupirim 08-Sep-2010 GENERIC ID # GDCI-129086-930

A,B A,B A,B A,B A,B

A,B A,B TEP TGAI or PAIRA EP; PAI; TGAI TGAI or PAIRA TGAI or PAIRA

TEP TEP 12 12 12 24 24

12 12 1 of Page

(8) (4, 11) (8) (10, 30)

(3, 12, 13, 14, 34) (3, 9, 13, 14, 16, 34) N

N N N N

N N 3OMB Approval 2070-0174 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Product Chemistry Data Requirements (Conventional Chemical) Terrestrial and Aquatic Nontarget Organisms Data Requirements (Conventional Chemical)

Toxicology Data Requirements (Conventional Chemical) 830.7050

850.1010 850.1075 850.2100 850.2200

870.7600 UV/Visible absorption

Aquatic invertebrate acute toxicity, test, freshwater daphnids Fish acute toxicity test, freshwater and marine Avian acute oral toxicity test Avian dietary toxicity test
Dermal penetration N/A - Phostebupirim Chemical # and Name: 129086 Phostebupirim 08-Sep-2010 GENERIC ID # GDCI-129086-930

A,B

A,B A,B A,B A,B

A,B EP; PAI; TGAI

TGAI, TEP TGAI, TEP EP; PAI; TGAI TGAI

CHOICE 8

12 12 12 12

24 2 of Page

(1, 5, 17, 19, 20, 25) (6, 18, 21, 26, 28, 31) (17, 20, 24, 29, 32) (2, 22, 23)
(33) N

N N N N

N 3Date OMB Approval 2070-0174 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Toxicology Data Requirements (Conventional Chemical) 870.7800

850.1790 none Immunotoxicity

Chironomid Sediment Toxicity Test Comparative Cholinesterase Assay N/A - Phostebupirim Chemical # and Name: 129086 Phostebupirim 08-Sep-2010 GENERIC ID # GDCI-129086-930

A,B

A,B A,B TGAI

EP; PAI; TGAI 12

12 12 3 of Page

(7, 15, 27) N

N N 3

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS N/A - Phostebupirim GDCI-129086-930

1 2 3 4 5

6
7

8 9 10 11 12 13 Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

This study is required for tebupirimphos-oxon. This is a requirement for tebuprimos-oxon. The study title on the DCI mailed out 9/8/2010 reads "Terrestrial plant toxicity, Tier 1 (seedling emergence)". The photodegradation in water is required for tebupirimphos and its degradate tebupirimphos oxygen analog (oxon). The freshwater fish test species for the TEP testing is the most sensitive of the species tested with the TGAI. Freshwater invertebrate and acute estuarine and marine organisms must also be tested with the EP or TEP using the same species tested with the TGAI. The freshwater fish test species for the TEP testing is the most sensitive of the species tested with the TGAI. Freshwater invertebrate and acute estuarine and marine organisms must also be tested with the EP or TEP using the same species tested with the TGAI. Sediment testing with estuarine test species is required if the product is expected to enter this environment in concentrations which the Agency believes to be significant because by runoff because of its expected use or mobility pattern. Data are required if: the estimated environmental concentration (EEC) is greater than 0.1 the acute EC50 value and the half-life in the aerobic soil metabolism study > 10 days and one of following conditions met: soil partition coefficient (Kd) is equal to or greater than > 50, log Kow > 3, or Koc > 1000. Use agency-wide guidance: USEPA 2001 Method for Assessing the Chronic Toxicity of Marine and Estuarine Sediment-associated Contaminants with the Amphipod Leptocheirus plumulosus EPA 600/R-01/020. The preferred sediment is formulated, guidance for the formulated sediment can be found in OECD 218 Sediment-Water Chironomid Toxicity Test using Spiked Sediment. Based on test variability for the endpoints of concern and the need to establish a NOAEC/LOAEC; it is recommended that for the L. plumulosus, 10 replicates per treatment with 20 neonates per replicate. For alternative test designs the protocol should discuss the power of the test. A protocol should be submitted for approval prior to testing. Requirement based on use patterns and other pertinent factors including, but not limited to, Henry's Law Constant of the chemical. In view of methodological difficulties with the study of photodegradation in air, prior consultation with the Agency regarding the protocol is recommended before the test is performed. Required for known phytotoxicants. Required for aquatic food and nonfood crop uses for aquatic sites that are intermittently dry. Such sites include, but are not limited to cranberry bogs and rice paddies. Not required when the electronic absorption spectra, measured at pHs 5, 7, and 9, of the chemical and its hydrolytic products, if any, show no absorption or tailing between 290 and 800 nm. Not required for known phytotoxicants. Not required for contained pesticide treatments such as bait boxes and pheromone traps unless adverse effects reports are received by the Agency. Case # and Name: DCI Number: 1 Page: of

Footnotes: The following footnotes are referenced in column two (5. Study Title) of the Requirements Status and Registrant's Response form. These footnotes apply in addition to any test notes included in 40 CFR Part 158 with respect to the particular data requirement. Use Categories Key: A - Terrestrial food crop B - Terrestrial feed crop 3

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS N/A - Phostebupirim GDCI-129086-930

14 15 16 17
18

19

20 21 22 23 24
25 26 27 Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

Not required for aquatic residential uses. In July 2009, revisions were made to harmonized guideline numbers and associated footnotes in 40 CFR. These revisions are not reflected in the data call-in (see 40 CFR parts 158). The whole sediment chronic invertebrates freshwater and marine study was not assigned a guideline number under 40 CFR parts 158. Generally not required for granular formulations. May be requested on a case-by-case basis.For greenhouse and indoor end-use products, data using the TGAI are required to support manufacturing-use products to be reformulated into these same end-use products or to support enduse products when there is no registered manufacturing-use product. Avian acute oral data are not required for liquid formulations for greenhouse and indoor uses. The study is not required if there is no potential for environmental exposure. EP or TEP testing is required for any product which meets any of the following conditions: i. The end-use pesticide will be introduced directly into an aquatic environment (e.g., aquatic herbicides and mosquito larvicides) when used as directed.i. The end-use pesticide will be introduced directly into an aquatic environment (e.g., aquatic herbicides and mosquito larvicides) when used as directed. ii. The maximum expected environmental concentration (MEEC) or the estimated environmental concentration (EEC) in the aquatic environment is greater than or equal to one-half the LC50or EC50of the TGAI when the EP is used as directed. iii. An ingredient in the end-use formulation other than the active ingredient is expected to enhance the toxicity of the active ingredient or to cause toxicity to aquatic organisms. EP or TEP testing is required for any product which meets any of the following conditions: i. The end-use pesticide will be introduced directly into an aquatic environment (e.g., aquatic herbicides and mosquito larvicides) when used as directed. ii. The maximum expected environmental concentration (MEEC) or the estimated environmental concentration (EEC) in the aquatic environment is greater than or equal to one-half the LC50or EC50of the TGAI when the EP is used as directed. iii. An ingredient in the end-use formulation other than the active ingredient is expected to enhance the toxicity of the active ingredient or to cause toxicity to aquatic organisms. Data using the TGAI are required to support all outdoor end-use product uses including, but not limited to turf. Data are generally not required to support end-use products in the form of a gas, a highly volatile liquid, a highly reactive solid, or a highly corrosive material. Data using the TGAI are required to support all outdoor end-use product uses including, but not limited to turf. Data are generally not required to support end-use products in the form of a gas, a highly volatile liquid, a highly reactive solid, or a highly corrosive material. Data using the TGAI are required to support all outdoor end-use product uses including but not limited to turf. Data are generally not required to support end use products in the form of a gas, a highly volatile liquid, a highly reactive solid, or a highly corrosive material. Data are required on waterfowl and upland bird species. Data are required on one passerine species and either one waterfowl species or one upland game bird species for terrestrial, aquatic, forestry, and residential outdoor uses. Data are preferred on waterfowl or upland game bird species for indoor and greenhouse uses. Data are required on one freshwater aquatic invertebrate species. Data are required on one estuarine/marine mollusk, one estuarine/marine invertebrate and one estuarine/marine fish species. Data are required if: the estimated environmental concentration (EEC) is greater than 0.1 the acute EC50 value and the half life in the aerobic soil metabolism study > 10 days and one of the following conditions is met: soil partition coefficient (Kd) is equal to or greater than > 50, log Kox > 1000. Use Agency -wide guidance: Test Method 100.4: Hyalella azteca 42-d Test for Measuring the Effects of sediment Associated Contaminants on Survival, Growth, and Reproduction and Test Method 100.5: Life-cycle Test for Measuing the Effects of Sediment-associated Contaminants on Chironomus dilutus or C. tentans in USEPA 2000 Methods for Measuring the Tocicity and Bioaccumulation of Sediment-associated Contaminants with Freshwater Invertebrates EPA 600R-99/064. The preffered sediment is formulated, guidance for the formulated sediment can be found in OCED 218 Sediment-Water Chironomid Toxicity Test using Spiked Sediment. Case # and Name: DCI Number: 2 Page: of 3

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS N/A - Phostebupirim GDCI-129086-930

28 29 30 31 32 33 34 Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

Based on test variability for the endpoints of concern and the need to establish a NOAEC/LOAEC the following number of replicates and test animals are reccommended: for the midge test with C. dilutus 16 replicates containing 12 test oranisms each (12 replicates at test initiation; 4 added at 10 daysfor auxillary males); for the freshwater amphipod H. azteca test of 12 replicates per treatment (4 for 28-d survival and growthand 8 for the remainder of the test) with 10 neonates per replicate. For alternative test designs the protocol should discuss the power of the test. A protocol should be submitted for approval prior to testing. Data are generally not required for outdoor residential uses, other than turf, unless data indicate that pesticide residues from the proposed use(s) can potentially enter waterways. Avian acute oral toxicity study is required for tebupirimphos-oxon. An aerobic soil metabolism study is required for tebupirimphos-oxon. Acute toxicity studies are required for tebupirimphos-oxon. Acute oral LD50 in passerine birds are required for tebupirimphos. A risk assessment assuming that dermal absorption is equal to oral absorption must be performed to determine if the study is required, and to identify the doses and duration of exposure for which dermal absorption is to be quantified. A Tier I and if trigged a Tier II is required for Tebupirimphos typical end-use product (TEP). Case # and Name: DCI Number: 3 Page: of 3

### United States Environmental Protection Agency Washington, D.C. 20460 LIST OF ALL REGISTRANTS SENT THIS DATA CALL-IN NOTICE N/A - Phostebupirim Case # and Name: 1 Page: of 1

5481 AMVAC CHEMICAL CORPORATION Co. Nr. Company Name Agent For Company 4695 MACARTHUR COURT, SUITE 1200 Address City ZIP NEWPORT BEACH 926601706 OMB Approval 2070-0174

State CA DCI Number: GDCI-129086-930

# LINKS TO FORMS: The pesticide registration forms that are listed below can be found at: http://www.epa.gov/opprd001/forms/ Link to C onfidential Statement of Formula and Instructions (Form # 8570 -4 

# ) http://www.epa.gov/opprd001/forms/8570 - 4.pdf C ertification of Attempt to Enter Into an Agreement With Registrants for Development of Data (Form # 8570 - 32 

# ) http://www.epa.gov/opprd001/forms/8570 - 32.pdf C ertification With Respect to Citation of Data (Form # 8570 - 34 

# ) http://www.epa.gov/opprd001/forms/8570 - 34.pdf