Support Documents for 

Significant New Use Rules (SNURs) on 

Premanufacture Notices (PMNs) 

P-09-193 and P-09-195 

EPA Docket EPA-HQ-OPPT-2010-1075 

 

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Index

A-001 Structure Activity Team (SAT) Reports for 

PMNs P-09-193 and P-09-195 

A-002 Initial Review Engineering Reports for 

PMNs P-09-193 and P-09-195 

A-003 Initial Review Exposure Reports for 

PMNs P-09-193 and P-09-195 

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A-001 

Structure Activity Team (SAT) Reports 

for PMNs P-09-193 and P-09-195 

 

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SAT Report

PMN Number: P-09-0193

SAT Date: 3/13/2009

Related cases:

Health related cases: 

Ecotox related cases: 

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 2 3

 Persistence Bioaccum Toxicity Comments

 2 1 2

Exposure Based Review:

Health:

Ecotox: No

Routes of exposure: Health: Dermal, inhalation, drinking water

Ecotox: All releases to water

Fate: ;

Keywords:

 Keywords: LIVER; KIDNEY; HEART; NEURO; ONCO; MUTA; DEVEL; 

IRR-E,MM,L,S; SENS-S,L; AQUATOX

Summary of Assessment:

 Fate:

Fate Summary: P-09-0193

FATE: 

Solid with MP = 88 EC (E)

log Kow = -0.94 (E); 

S > 10 g/L at 25 EC (E)

VP < 1.0E-6 torr at 25 EC (E)

BP > 400 EC (E)

H < 1.00E-8 (E)

log Koc = 1.00 (E)

log Fish BCF = 0.50 (E) 

POTW removal (%) = 0-90 via possible partial biodeg

Time for complete ultimate aerobic biodeg = wk-mo

Sorption to soils/sediments = low

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PBT Potential: P2B1

*CEB FATE: Migration to ground water = rapid

 Health:

 Health Summary: Absorbed all routes (analog/pchem); expected to be an 

alkylating agent. Concern for oncogenicity, mutagenicity, developmental toxicity, dermal and 

respiratory sensitization, and irritation to all tissues from the alkylating activity of the compound. 

Concern for liver, kidney, heart, and developmental (uncertain) toxicity; and neurotoxicity based 

on data for analogues submitted as rat developmental toxicity LOEL = 2000 

mg/kg; , rat 90-day oral NOEL = 100 mg/kg, LOEL = 200 mg/kg, convulsions, liver, 

kidney, and heart toxicity

 Ecotox:

Test 

Organism

Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 1500

daphnid 48-h LC50 190

green algal 96-h EC50 32

fish _ chronic value 46

daphnid chronic value 0.078

algal _ chronic value 27

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic Value _

Ecotox Values Comments: Predictions based on SARs for ; SAR chemical 

class = MW 338; log Kow= -0.94 (EPI); solid with unknown mp (P); S = 471 

g/L at 25 C (P); pH7; hardness <150.0 mg/L as CaCO3; ECs based on 100% active ingredients 

and mean measured concentrations; and TOC <2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

8

SARs

SAR Class

Ecotox Factors Comments: 

 SAT Chair: L Keifer 564-8916

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SAT Report

PMN Number: P-09-0195

SAT Date: 3/13/2009

Related cases:

Health related cases: 

Ecotox related cases: 

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 2 2

 Persistence Bioaccum Toxicity Comments

 2 1 2

Exposure Based Review:

Health:

Ecotox: No

Routes of exposure: Health: Dermal, inhalation, drinking water

Ecotox: All releases to water

Fate: ;

Keywords:

 Keywords: LIVER; KIDNEY; HEART; NEURO; ONCO; MUTA; DEVEL; 

IRR-E,MM,L,S; SENS-S,L; AQUATOX

Summary of Assessment:

 Fate:

Fate Summary: P-09-0195

FATE: 

Solid with MP = 90 EC (E)

log Kow = -1.12 (E); 

S > 10 g/L at 25 EC (E)

VP < 1.0E-6 torr at 25 EC (E)

BP > 400 EC (E)

H < 1.00E-8 (E)

log Koc = 2.81 (E)

log Fish BCF = 0.50 (E) 

POTW removal (%) = 0-90 via possible partial biodeg

Time for complete ultimate aerobic biodeg = mo

Sorption to soils/sediments = low - moderate

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PBT Potential: P2B1

*CEB FATE: Migration to ground water = moderate - rapid

 Health:

 Health Summary: Expect poor absorption via all routes (analog/pchem); 

expected to be an alkylating agent. Concern for oncogenicity, mutagenicity, developmental 

toxicity, dermal and respiratory sensitization, and irritation to all tissues from the alkylating 

activity of the compound. Concern for liver, kidney, heart, and developmental (uncertain) 

toxicity; and neurotoxicity based on data for analogues submitted as rat 

developmental toxicity LOEL = 2000 mg/kg; , rat 90-day oral NOEL = 100 mg/kg, 

LOEL = 200 mg/kg, convulsions, liver, kidney, and heart toxicity

 Ecotox:

Test 

Organism

Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 6700

daphnid 48-h LC50 360

green algal 96-h EC50 56

fish _ chronic value 89

daphnid chronic value 0.12

algal _ chronic value 50

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic Value _

Ecotox Values Comments: Predictions based on SARs for ; SAR chemical 

class = MW 509; log Kow= -1.12 (EPI); solid with unknown mp (P); S = 471 

g/L at 25 C (P); pH7; hardness <150.0 mg/L as CaCO3; ECs based on 100% active ingredients 

and mean measured concentrations; and TOC <2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

12

SARs

SAR Class

Ecotox Factors Comments: 

 SAT Chair: L Keifer 564-8916

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A-002 

Initial Review Engineering Reports 

 for PMNs P-09-193 and P-09-195 

 

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INITIAL REVIEW ENGINEERING REPORT

P-09-0193

Focus Ready Draft 3/19/2009

ENGINEER: Arnold \ DDH

PV (kg/yr): 

Revision Notes/Assessment Overview:

SUBMITTER:

USE: Flame retardant monomer for polyurethane. 

OTHER USES:

MSDS: Yes LABEL: No

Gen Eqpt: appropriate chemical resistant gloves/ safety glasses with side shields/ general ventilation or local

exhaust

Respirator: in opeations where the exposure limits can be exceeded, wear a NIOSH approved respirator/ if a 

respirator is worn, OSHA requires compliance with its respiratory protection program (29 CFR 1910.134)

Health Effects: inhalation may cause irritation of the nose and throat, headache, nausea, and drowsiness/ skin 

contact may cause irritation with discomfort/ eye contact causes irriation and may injure cornea/ moderately toxic if 

ingested.

TLV/PEL: - none established for PMN.

CRSS: 

Chemical Name: Phosphonic acid, [2-[bis(2-hydroxyethyl)amino]ethyl]-, bis(2-chloroethyl) ester

S-H2O: 471 g/L @ 

VP: 1.0E-6 torr @ 

MW: 338 0.0%<500 0.0%<1000

Physical State and Misc CRSS Info:

 

 

Consumer Use: No

SAT (concerns): (3/13/2009):

Migration to groundwater: Rapid

PBT rating: P2 B1 T2

Health: 2, Dermal, Drinking Water, Inhalation

Eco: 3, Water (All releases to water with a CC = 8 ppb)

OCCUPATIONAL EXPOSURE RATING: 1A

NOTES & KEY ASSUMPTIONS:

Generated by the 06/07/2005 version of ChemSTEER. 

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POLLUTION PREVENTION CONSIDERATIONS:

P2 REC:

EXPOSURE-BASED REVIEW: No (0 criteria met)

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P-09-0193

Manufacturing

Number of Sites/Location: 1 

Basis: 

Process Description:

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY

RELEASE TOTAL

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY

Tot. # of workers exposed via assessed routes: 

Basis:

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P-09-0193

Use: 

Number of Sites/Location: 1 submitter site(s) 

Basis: 

Process Description:

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY

RELEASE TOTAL

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY

Tot. # of workers exposed via assessed routes: 

Basis: 

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INITIAL REVIEW ENGINEERING REPORT

P-09-0195

Focus Ready Draft 3/19/2009

ENGINEER: Arnold \ DDH

PV (kg/yr): 

Revision Notes/Assessment Overview:

SUBMITTER:

USE: Flame retardant monomer for polyurethane. 

OTHER USES:

MSDS: Yes LABEL: No

Gen Eqpt: appropriate chemical resistant gloves/ safety glasses with side shields/ general ventilation or local

exhaust

Respirator: in opeations where the exposure limits can be exceeded, wear a NIOSH approved respirator/ if a 

respirator is worn, OSHA requires compliance with its respiratory protection program (29 CFR 1910.134)

Health Effects: inhalation may cause irritation of the nose and throat, headache, nausea, and drowsiness/ skin 

contact may cause irritation with discomfort/ eye contact causes irriation and may injure cornea/ moderately toxic if 

ingested.

TLV/PEL: - none established for PMN.

CRSS: (12:00:00 AM):

Chemical Name:

S-H2O: 58 g/L @ 

VP: 1.0E-6 torr @ 

MW: 509 0.0%<500 0.0%<1000

Physical State and Misc CRSS Info:

 

 

Consumer Use: No

SAT (concerns): (3/13/2009):

Migration to groundwater: Moderate to Rapid

PBT rating: P2 B1 T2

Health: 2, Dermal, Drinking Water, Inhalation

Eco: 2, Water (All releases to water with a CC = 12 ppb)

OCCUPATIONAL EXPOSURE RATING: 1A

NOTES & KEY ASSUMPTIONS:

Generated by the 06/07/2005 version of ChemSTEER. 

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POLLUTION PREVENTION CONSIDERATIONS:

P2 REC:

EXPOSURE-BASED REVIEW: No (0 criteria met)

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P-09-0195

Manufacturing

Number of Sites/Location: 1 

Basis: 

Process Description:

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY

RELEASE TOTAL

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY

Tot. # of workers exposed via assessed routes:

Basis:

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P-09-0195

Use: 

Number of Sites/Location: 1 

Basis: 

Process Description:

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY

RELEASE TOTAL

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY

Tot. # of workers exposed via assessed routes: 

Basis:

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A-003 

Initial Review Exposure Reports 

 for PMNs P-09-193 and P-09-195 

 

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Date 3/18/09 Page of 

INITIAL REVIEW EXPOSURE REPORT 

Summary Page 

Chemical ID: P090193 Reviewer: Cinalli 

Endpoints-Assessed Table 

Reasons for not assessing releases 

Endpoints/Assessment 

Cycles1

Releases 

Assessed 

in 

NCEM2? 

No XB 

Testing 

Required 

No 

Hazard 

Concern 

No 

Releases 

Release 

Below 

Acute 

Threshold5

Release 

Below 

Chronic 

Threshold5

Other 

Ingestion 

 Surface water No NA 

 Ground water (landfill) No NA 

 Consumer Use: DtD2 No NA 

Inhalation 

 Air: incineration (stack) No NA 

 Air: fugitive No NA 

 Consumer Use: CEM3 No NA 

Dermal 

 Consumer Use: CEM No NA 

Eco 

 Surface water: ADR 

conc and/or PDM4

No NA 

 Consumer Use: DtD No NA 1

Assessment cycles are endpoint concentrations and dose calculations within the NCEM2 model. 2

Down-the-Drain 

3

Consumer Exposure Model 

4

Probabilistic Dilution Model 

5

The threshold values for assessing endpoints are 1 mg/day for acute doses and 1 mg/year for chronic doses. 

EAB DROP: Release information for this compound does not meet criteria for preparation of an exposure 

assessment in the Exposure Assessment Branch=s (EAB) Initial Review Exposure Report (this report). 

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Date 3/18/09 Page of 

INITIAL REVIEW EXPOSURE REPORT 

Summary Page 

Chemical ID: P090195 Reviewer: Cinalli 

Endpoints-Assessed Table 

Reasons for not assessing releases 

Endpoints/Assessment 

Cycles1

Releases 

Assessed 

in 

NCEM2? 

No XB 

Testing 

Required 

No 

Hazard 

Concern 

No 

Releases 

Release 

Below 

Acute 

Threshold5

Release 

Below 

Chronic 

Threshold5

Other 

Ingestion 

 Surface water No NA X 

 Ground water (landfill) No NA X 

 Consumer Use: DtD2 No NA 

Inhalation 

 Air: incineration (stack) No NA 

 Air: fugitive No NA X 

 Consumer Use: CEM3 No NA 

Dermal 

 Consumer Use: CEM No NA 

Eco 

 Surface water: ADR 

conc and/or PDM4

No NA X 

 Consumer Use: DtD No NA 1

Assessment cycles are endpoint concentrations and dose calculations within the NCEM2 model. 2

Down-the-Drain 

3

Consumer Exposure Model 

4

Probabilistic Dilution Model 

5

The threshold values for assessing endpoints are 1 mg/day for acute doses and 1 mg/year for chronic doses. 

EAB DROP: Release information for this compound does not meet criteria for preparation of an exposure 

assessment in the Exposure Assessment Branch=s (EAB) Initial Review Exposure Report (this report). 

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