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Exhibit 10.24    
    


ACTIVE INGREDIENT SUPPLY AGREEMENT  


Between
the companies: 



	•
	SIRTON PHARMACEUTICALS S.p.A, with registered office in Villa Guardia (COMO), Piazza XX Settembre, 2, Inland Revenue code
01192270138, in the person of Dr. Sauro Carsana, Director (hereinafter referred to as SIRTON) 



AND



	•
	GENTIUM S.p.A., with registered office in Villa Guardia (COMO), Piazza XX Settembre, 2, Inland Revenue code 02098100130, in
the person of Dr. Laura Iris Ferro, Chairwoman (hereinafter referred to as GENTIUM);




WHEREAS:



	•
	GENTIUM is interested in the manufacture and marketing of active ingredients for pharmaceutical use and raw materials for
pharmaceutical use;



	•
	SIRTON uses such active ingredients in manufacturing pharmaceutical preparations 




ALL THIS HAVING BEEN STATED, THE PARTIES HEREBY STIPULATE AS FOLLOWS:



	1.
	GENTIUM undertakes to supply SIRTON with its active ingredients on the basis of regular purchasing orders issued by SIRTON;



	2.
	SIRTON undertakes to supply GENTIUM with purchasing orders three months in advance with respect to the date of supply and with
purchasing forecasts for a period of 12 months on the basis of which GENTIUM may plan its manufacturing activities;



	3.
	The
prices for the transfer of each active ingredient supplied are established as per the table below: 







	Product
 
	 	Unit of measure
	 	Unit price

	Pure Urokinase	 	M.U.	 	59.00
	Calcic Heparin for Inj.	 	M.U.	 	8.80
	Defibrotide for Inj.	 	K.S.	 	1,446.00
	Oral Defibrotide	 	K.S.	 	679.00
	Sulglycotide	 	K.S.	 	210.00
	Glucidamine	 	K.S.	 	110.00






	4.
	SIRTON undertakes to pay the amounts agreed upon above against presentation of regular invoices with payment by direct remittance at
60 days from the end of the month of the date of invoice.



	5.
	This
agreement shall become effective as of 02/01/2004, expires on 31/12/2004, and is understood to be tacitly renewed each year, barring cancellation to be notified at least
1 month prior to expiry.



	6.
	The
Parties reserve the possibility of redefining the terms agreed upon, at the time of expiry or during the period of validity of the agreement, in the event of significant changes in
the services rendered or their cost, without detriment to the right of withdrawal in the event of non-acceptance.



	7.
	The
Parties formally acknowledge as of now the possibility of agreeing upon changes in the compensations defined above according to the effective extent of the services requested. 



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	8.
	All
and any communications concerning this Agreement shall be made in writing, by registered letter to be delivered by hand, transmitted by fax, telegram or registered letter with
advice of receipt and dispatched to the registered office of each of the Parties.



	9.
	All
and any controversies relating to this Agreement shall be settled by a Board of Arbitrators; each of the two Parties shall appoint its own arbitrator, who in turn shall take steps
to choose a third member as Chairman of the Board of Arbitrators.



	10.
	This
Agreement cancels and replaces all and any previous agreements for the supply of Services between the Parties, and may not be amended or changed in any way whatsoever with the
exception of that explicitly contemplated herein or by written agreement of the Parties signed by their authorised representatives. 




Read,
confirmed and undersigned. 


Villa
Guardia, 2nd January, 2004 



	Sirton Pharmaceuticals S.p.A

A Director	 	Gentium S.p.A.
 The Chairwoman
	/s/  Sauro Carsana      
 Dr. Sauro Carsana	 	/s/  Laura Iris Ferro      
 Dr. Laura Iris Ferro




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Exhibit 10.24