<PAGE>

                                                                   EXHIBIT 10.18

                              CONSULTING AGREEMENT

THIS AGREEMENT made as of the 28th day of January, 2002,

AMONG:

         ASPREVA PHARMACEUTICALS CORPORATION, a corporation incorporated under
         the laws of Canada, and having its address at 2600 - 700 West Georgia
         Street, Vancouver, British Columbia, V7Y 1B3

         (the "CORPORATION")

AND:

         GENWORKS INC., a company duly incorporated pursuant to the laws of Nova
         Scotia and having an office at 4484 West 7th Avenue, Vancouver, British
         Columbia, V6R 1W9

         (the "CONSULTANT")

AND:

         DR. MICHAEL HAYDEN, of 4484 West 7th Avenue, Vancouver, British
Columbia, V6R 1W9

         (the "CONSULTANT'S DESIGNATED EMPLOYEE")

WITNESSES THAT WHEREAS:

A. The Corporation is carrying on business as a pharmaceutical company,
specializing in the development and commercialization of rare disease
therapeutics and orphan drugs as defined by the U.S. Orphan Drug Act (the
"Business");

B. The Corporation wishes to retain the services of the Consultant to aid and
assist the Corporation as a consultant by providing certain services in
scientific and clinical issues and other medical or human genetic topics
mutually agreed upon with the Corporation and the Consultant's Designated
Employee shall serve as the Chair of the Corporation's Medical Advisory
Committee;

C. The Consultant's Designated Employee is an employee and principal shareholder
of the Consultant and is qualified to provide the services on behalf of the
Consultant; and

D. In consideration of and as a condition of the Corporation entering into this
Agreement with the Consultant, the Consultant's Designated Employee has agreed
to be a party to this Agreement as hereinafter provided.

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                                      - 2 -

1. Engagement The Corporation does hereby appoint and engage the Consultant as
its consultant and advisor with respect to the services referred to in Section 2
hereof, for the compensation and the term hereinafter set forth, and the
Consultant hereby accepts such appointment and engagement by the Corporation,
all upon and subject to the terms and conditions of this Agreement.

2. Services During the term of this Agreement, the Consultant agrees to provide
to the Corporation in a good and faithful manner, using its best efforts and in
a manner that will promote the interests of the Corporation, those advisory and
consulting services (the "SERVICES") described in Schedule A attached hereto.
The Corporation and the Consultant agree that in providing the Services, the
Consultant shall be responsible to and shall report to the Chief Executive
Officer of the Corporation or to such other person as the Chief Executive
Officer of the Corporation shall from time to time designate (the
"REPRESENTATIVE").

3. Personnel The Consultant agrees with the Corporation to cause the Services to
be provided on behalf of the Consultant exclusively by the Consultant's
Designated Employee.

4. Limited Authority as Agent The Consultant and the Consultant's Designated
Employee agree that neither of them may act as an agent of the Corporation
except with the express prior written authority of the Corporation. Without
limiting the generality of the foregoing, neither the Consultant nor the
Consultant's Designated Employee shall commit or be entitled to commit the
Corporation to any obligation whatsoever nor shall they incur or be entitled to
incur any debt or liability whatsoever on behalf of the Corporation, without in
each case the express prior written authority of the Corporation. Any
obligations, debts or liabilities incurred other than as aforesaid shall be
exclusively for the account of the Consultant and the Consultant's Designated
Employee.

5. Term and Renewal The term of this Agreement (the "TERM") shall commence on
March 1, 2002 and shall terminate on March 1, 2006, unless earlier terminated as
hereinafter provided. This Agreement will be extended for successive terms of
one (1) year each on the same terms and conditions set out herein unless the
parties otherwise agree in writing or unless this Agreement is terminated as
hereinafter provided.

6. Termination by the Parties The Consultant, the Consultant's Designated
Employee and the Corporation shall have the right to terminate this Agreement as
follows:

         (a)      by mutual consent with such notice or compensation as may be
                  agreed in writing by the parties;

         (b)      by the Corporation, at its option without notice or
                  compensation, for cause at any time. Without restricting the
                  generality of the term in any way, "cause" shall be deemed to
                  include the following:

                  (i)      the failure to provide to the Corporation the minimum
                           full time equivalent service level set out in
                           Schedule A hereto, and such failure continues for
                           longer than 30 days after the Consultant receives
                           written notice from the Corporation of such failure;

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                                     - 3 -

                  (ii)     a material breach of the provisions of this Agreement
                           by the Consultant or the Consultant's Designated
                           Employee;

                  (iii)    the commission of theft, embezzlement, fraud,
                           obtaining funds or property under false pretences or
                           similar acts of misconduct with respect to the
                           property of the Corporation or its employees or the
                           Corporation's clients or suppliers by the Consultant
                           or the Consultant's Designated Employee;

                  (iv)     any oral or written representations made by the
                           Consultant or the Consultant's Designated Employee to
                           the Corporation with the intent to deceive or mislead
                           the Corporation;

                  (v)      the commission of malfeasance, dishonesty or breach
                           of trust against the Corporation or its employees or
                           the Corporation's clients or suppliers by the
                           Consultant or the Consultant's Designated Employee;

                  (vi)     the entering of a guilty plea or any conviction of
                           the Consultant's Designated Employee for any crime
                           involving fraud, misrepresentation or for a serious
                           criminal offence which impacts adversely on the
                           Corporation; and

                  (vii)    any other matter constituting just cause at common
                           law.

         (c)      by the Corporation, at its option without notice or
                  compensation, if the Consultant's Designated Employee becomes
                  and remains physically and mentally incapable of providing the
                  Services for a period of not less than six (6) consecutive
                  months;

         (d)      by the Corporation, at its option without notice or
                  compensation, upon the death of the Consultant's Designated
                  Employee; and

         (e)      by the Corporation, at any time, without cause, upon delivery
                  of six (6) months written notice provided that the Corporation
                  shall always have the right in lieu of the notice period to
                  pay the Consultant an amount equal to the amount that would
                  have been earned by the Consultant during the notice period if
                  the Consultant were to provide the Services during the notice
                  period in accordance with this Agreement.

         (f)      by the Consultant, upon delivery of a written notice providing
                  at least 3 months notice to that affect to the Corporation.

7. No Damages for Termination Neither the Consultant nor the Consultant's
Designated Employee shall, as a result of any termination of this Agreement or
the Term in accordance with Section 6 above, be entitled to any notice, fees,
payments or damages arising by virtue of or in any way relating to the
Consultant's and the Consultant's Designated Employee's relationship to the
Corporation, except:

         (a)      those (if any) specified in Section 6 or Section 9, as
                  applicable; and

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                                     - 4 -

         (b)      fees and bonuses earned by the Consultant hereunder that are
                  unpaid at the effective date of any termination, and expenses
                  to which the Consultant is entitled to reimbursement hereunder
                  as at the effective date of any termination.

8. Fees Provided the Consultant renders the Services satisfactorily in
accordance with this Agreement, and provided the Consultant and the Consultant's
Designated Employee are not in default under this Agreement, the Corporation
agrees to pay to the Consultant for the Services rendered by the Consultant
during the Term of this Agreement, an amount based on the % full time equivalent
("FTE") provided to the Corporation which shall not be less than 20% FTE and not
exceed 50% FTE unless agreed to by the parties. The calculation will be based on
a FTE fee of $200,000 per annum and be adjusted annually at time of performance
review by the Corporation's compensation committee. The Consultant shall invoice
the Corporation monthly for the monthly fee payable hereunder plus GST. Each
invoice submitted shall be satisfactory in form, substance and detail to the
Corporation acting reasonably. It is expressly agreed by the parties that the
invoices submitted by the Consultant will not have to detail all time spent by
the Consultant in providing the Services. No fees shall be payable by the
Corporation nor accrue to the Consultant pursuant to this Agreement until the
Corporation has completed offerings of its equity securities raising aggregate
gross proceeds of at least $2 million.

9. Expenses The Consultant shall be reimbursed by the Corporation for all
ordinary and reasonable travelling and other out-of-pocket expenses legitimately
incurred in connection with the provision of the Services. The Consultant shall
seek pre-authorization from the Corporation for any expense in excess of $6,000.
Any expense outside such limitations shall be considered a business expense of
the Consultant, and will not be reimbursed to the Consultant except with the
approval in writing of the Chief Executive Officer. The Consultant shall be
required to furnish to the Corporation satisfactory statements and vouchers as
and when required as detailed in the policy statements of the Corporation as
revised from time to time regarding travel and promotion expenses as a condition
precedent to entitlement for reimbursement as aforesaid.

10. Bonuses The Consultant shall be eligible for bonuses based on the
performance of the Corporation and the Services provided by the Consultant and
the Consultant's Designated Employee hereunder. All bonuses shall be at the sole
discretion of the Board.

11. Disclosure of Conflicts of Interest During the term of this Agreement, the
Consultant shall promptly, fully and frankly disclose to the Corporation in
writing:

         (a)      the nature and extent of any interest the Consultant or the
                  Consultant's Designated Employee or any Affiliate or Associate
                  (as hereinafter defined) of either of them has or may
                  foreseeably have, directly or indirectly, in any contract or
                  transaction or proposed contract or transaction of or with the
                  Corporation or any subsidiary or affiliate of the Corporation;
                  and

         (b)      every office the Consultant or the Consultant's Designated
                  Employee or any Affiliate or Associate of either of them may
                  hold or acquire, and every property the Consultant or the
                  Consultant's Designated Employee or any Affiliate or Associate
                  of either of them may possess or acquire, whereby directly or
                  indirectly

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                                     - 5 -

                  a duty or interest might be created in conflict with the
                  interests of the Corporation or the duties and obligations of
                  the Consultant or the Consultant's Designated Employee under
                  this Agreement; and

         (c)      the nature and extent of any conflict referred to in
                  subparagraph (b) above.

In this Agreement, the expressions "AFFILIATE" and "ASSOCIATE" shall include all
those persons and entities that are included within the definitions or meanings
of "affiliate" and "associate" respectively as set forth in sections 1(l) and
1(2) of the Company Act (British Columbia) as amended from time to time, or any
successor legislation of similar force and effect, and "Associate" shall also
include the parents, brothers and sisters of the Consultant's Designated
Employee.

12. Avoidance of Conflicts of Interest The Consultant and the Consultant's
Designated Employee acknowledge that it is the policy of the Corporation that
all interests and conflicts of the sort described in Section 11 be avoided, and
the Consultant agrees to comply with and to cause the Consultant's Designated
Employee to comply with all policies or directives of the Corporation from time
to time regulating, restricting or prohibiting circumstances giving rise to
interests or conflicts of the sort described in Section 11 above. During the
Term of this Agreement, the Consultant and the Consultant's Designated Employee
shall not enter into any agreement, arrangement or understanding with any other
person or entity that would in any way conflict or interfere with this Agreement
or the duties and obligations of the Consultant or the Consultant's Designated
Employee under this Agreement or that would otherwise prevent the Consultant or
the Consultant's Designated Employee from performing the Services hereunder, and
the Consultant and the Consultant's Designated Employee hereby represent and
warrant that neither the Consultant nor the Consultant's Designated Employee nor
any Affiliate or Associate of either of them has entered into any such
agreement, arrangement or understanding.

13. Confidentiality and Assignment of Inventions. Concurrently with execution
and delivery of this Agreement and in consideration of the Consultant's and the
Consultant's Designated Employee's relationship with the Corporation, the
Consultant, the Consultant's Designated Employee and the Corporation will enter
into a "Confidentiality Agreement and Assignment of Inventions" in the form
attached hereto as SCHEDULE B.

14. Non-Competition and Non-Solicitation The Consultant and the Consultant's
Designated Employee each covenant, undertake and agree with the Corporation that
during the term of this Agreement and for a period of 6 months from the date of
termination thereof, neither of them will, on their own behalf or on behalf of
any Person, whether directly or indirectly, in any capacity whatsoever
including, without limitation, as an employer, employee, principal, agent, joint
venturer, partner, shareholder or other equity holder, independent contractor,
licensor, licensee, franchisor, distributor, consultant, supplier, trustee or
alone, through or in connection with any Person:

         (a)      carry on or be engaged in, concerned with or interested in, or
                  advise, invest in or give financial assistance to, or permit
                  either of their names to be used in connection with any
                  business, enterprise or undertaking that is competitive in the

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                                     - 6 -

                  Business of the Corporation, except as may be expressly
                  permitted in writing by the Corporation; or

         (b)      either directly or indirectly assist any Person to employ,
                  offer employment to or solicit the employment of or otherwise
                  entice away from the employment of the Corporation, any
                  individual who is employed by the Corporation at the date of
                  termination of this Agreement or who was employed by the
                  Corporation within the 6 month period immediately preceding
                  the date of this Agreement.

In this Agreement, "PERSON" shall mean any individual or other entity or group
of individuals or other entities possessed of juridical personality, including,
without limitation, a natural person, firm, association, syndicate, company,
corporation, cooperative, partnership, trust, unincorporated association,
affiliate or governmental body, and pronouns when they refer to a Person shall
have a similarly extended meaning.

15. Provisions Reasonable. It is acknowledged that:

         (a)      the Corporation has operated and competed and will operate and
                  compete in a global market, with respect to the Business of
                  the Corporation;

         (b)      competitors of the Corporation and the Business are located in
                  countries around the world;

         (c)      in order to protect the Corporation adequately, any enjoinder
                  of competition would have to apply world wide;

         (d)      during the term of this Agreement, the Consultant and the
                  Consultant's Designated Employee have acquired and will
                  acquire knowledge of, and come into contact with, initiated
                  and established relationship both existing and new clients,
                  customers, suppliers, principals, contacts and prospects of
                  the Corporation;

         (e)      in light of the foregoing, the provisions of Section 14 above
                  are reasonable and necessary for the proper protection of the
                  business, property and goodwill of the Corporation and the
                  Business.

16. Severability If any provision of this Agreement shall for any reason be held
to be excessively broad as to duration, scope, activity, subject matter or
otherwise, such provision shall be construed by limiting and reducing it so as
to be enforceable to the extent compatible with applicable law. If,
notwithstanding the foregoing, any provision of this Agreement is to be held to
be invalid or illegal, then such invalid, illegal provision shall be severable
and severed from the other provisions of this Agreement and the Agreement shall
remain to be construed as if such invalid, illegal provision had never been
contained herein.

17. Remedies The Consultant and the Consultant's Designated Employee each
acknowledge and agree that any breach or threatened breach of this Agreement by
either of them could cause irreparable damage to the Corporation or its
partners, subsidiaries or affiliates, that such harm could not be adequately
compensated by the Corporation's recovery of monetary

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                                     - 7 -

damages, and that in the event of a breach by the Consultant or the Consultant's
Designated Employee, the Corporation shall have in addition to any and all other
remedies at law or in equity, the right to an injunction, specific performance
or other equitable relief, as well as any equitable accounting of all of the
Consultant's or the Consultant's Designated Employee's profits or benefits
arising out of such breach, to prevent any violation by the Consultant or the
Consultant's Designated Employee of any of the provisions of this Agreement
including, without limitation, the provisions of Sections 11, 12, 13 and 14. In
the event of any dispute under any of Sections 11, 12, 13 and 14, the Consultant
and the Consultant's Designated Employee agree that the Corporation shall be
entitled, without showing actual damages, to a temporary or permanent injunction
restraining conduct of the Consultant and/or the Consultant's Designated
Employee pending a determination of such dispute and that no bond or other
security shall be required from the Corporation in connection therewith. The
Consultant and the Consultant's Designated Employee acknowledge and agree that
the remedies of the Corporation specified in this Agreement are in addition to
and not in substitution for any other rights and remedies of the Corporation at
law or in equity and that all such rights and remedies are cumulative and not
alternative or exclusive of any other rights or remedies and that the
Corporation may have recourse to any one or more of its available rights and
remedies as it shall see fit.

18. Waiver Any waiver of any breach or default under this Agreement shall only
be effective if in writing signed by the party against whom the waiver is sought
to be enforced, and no waiver shall be implied by indulgence, delay or other
act, omission or conduct. Any waiver shall only apply to the specific matter
waived and only in the specific instance in which it is waived.

19. Governing Laws This Agreement shall be governed by and interpreted in
accordance with the laws of the Province of British Columbia and applicable laws
of Canada, and the parties hereto attorn to the exclusive jurisdiction of the
federal and provincial courts of such province.

20. Survival of Terms The representations, warranties, covenants, agreements,
obligations and liabilities of the Consultant and of the Consultant's Designated
Employee under any and all of Sections 12, 13, 14, 21 and 22 of this Agreement
shall survive any expiration or termination of this Agreement or of the Term.
Any expiration or termination of this Agreement or of the Term shall be without
prejudice to any rights and obligations of the parties hereto arising or
existing up to the effective date of such expiration or termination, or any
remedies of the parties with respect thereto.

21. No Assignment The Consultant acknowledges and agrees that:

         (a)      the Services contracted for under this Agreement are the
                  personal services of the Consultant to be provided on its
                  behalf by the Consultant's Designated Employee;

         (b)      the Consultant may not delegate or subcontract for any of its
                  duties or obligations under this Agreement except to the
                  Consultant's Designated Employee as provided herein; and

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                                     - 8 -

         (c)      the rights and interests of the Consultant hereunder may not
                  be sold, transferred, assigned, pledged or mortgaged, without
                  the prior written consent of the Corporation which may be
                  unreasonably withheld.

22. Relationship It is expressly acknowledged and agreed by the parties hereto
that the only relationship of the Consultant to the Corporation created by this
Agreement shall for all purposes be that of an independent contractor, and the
Consultant's Designated Employee shall for all purposes be an employee of the
Consultant and not an employee of the Corporation. The Consultant and the
Consultant's Designated Employee further acknowledge and agree that, except as
provided in this Agreement, the Consultant and the Consultant's Designated
Employee will not be entitled to any compensation, remuneration or benefits from
the Corporation in connection with any matter or thing contemplated by or done
pursuant to this Agreement. The Consultant and/or the Consultant's Designated
Employee shall, at their own expense, pay all income taxes, employment
insurance, Canada Pension Plan and Workers Compensation contributions, and all
other taxes, charges and contributions levied as required by all competent
governmental authority in respect of the monies paid to the Consultant under
this Agreement.

The Consultant and the Consultant's Designated Employee shall indemnify and hold
harmless the Corporation from and against all assessments, claims, liabilities,
costs, expenses and damages that the Corporation may suffer or incur with
respect to any such benefits, and the Consultant agrees that the Corporation may
set off any such assessments, claims, liabilities, costs, expenses and damages
against any fees or other amounts payable by the Corporation to the Consultant.

23. Taxes Based on the relationships of the parties as described in Section 22,
the Consultant and the Consultant's Designated Employee covenant and agree to
pay and be responsible for all income taxes and all other taxes whatsoever now
or hereafter payable in connection with any fee, remuneration or compensation
provided under this Agreement or any compensation or benefits provided by the
Consultant to the Consultant's Designated Employee pursuant to their employment
relationship. The Consultant and the Consultant's Designated Employee shall,
jointly and severally, indemnify and hold harmless the Corporation from all
assessments, claims, demands, costs, expenses and liability that the Corporation
may ever suffer or incur with respect to any such taxes.

24. Notices Any notice or other communication under this Agreement or in
connection herewith shall be in writing and shall be delivered or faxed to the
Consultant, the Consultant's Designated Employee or the Corporation at the
addresses or fax numbers set out below. If the address, fax number or telephone
numbers set out below shall change during the Term, the party shall promptly
provide the new address, fax number or telephone number to the other parties:

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                                     - 9 -

         If to the Corporation:

                  Aspreva Pharmaceuticals Corporation
                  c/o Farris, Vaughan, Wills & Murphy
                  2600 - 700 West Georgia Street
                  Vancouver, BC, V7Y 1B3
                  Attn:  R. Hector MacKay-Dunn
                  Facsimile: (604) 661-9349

         If to the Consultant:

                  Genworks Inc.
                  4484 West 7th Avenue
                  Vancouver, BC, V6R 1W9

         If to the Consultant's Designated Employee:

                  Michael Hayden
                  4484 West 7th Avenue
                  Vancouver, BC, V6R 1W9

         Any notice delivered or faxed shall be deemed to have been given and
         received on the first business day following the date of delivery or
         fax.

25. Interpretation If the sense or context of this Agreement so requires, the
singular shall be construed to include the plural and vice versa, and the neuter
shall be construed to include the feminine or masculine or body politic or body
corporate and vice versa. In this Agreement "herein", "hereby", "hereunder",
"hereof", "hereto" and words of similar import, refer to this Agreement as a
whole and not to any particular Section or part of this Agreement. The headings
and captions of Sections of this Agreement are inserted for convenience of
reference only and are not to be considered when interpreting this Agreement.
Any covenants or agreements made by both the Consultant and the Consultant's
Designated Employee shall be joint and several covenants and agreements of such
parties. All sums of money set forth in this Agreement are expressed in Canadian
dollars.

26. Independent Legal Advice The Consultant and the Consultant's Designated
Employee acknowledge that they have each read and understood this Agreement and
all of its terms and conditions, and acknowledge that they have each had an
opportunity to obtain such legal and other advice about it as deemed necessary.

27. Time Due to the time sensitive nature of the Corporation's business, time is
of the essence.

28. Enurement Subject to Section 21, this Agreement shall enure to the benefit
and be binding on the respective heirs, executors, administrators, successors
and assigns of the Corporation, the Consultant and the Consultant's Designated
Employee.

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                                     - 10 -

29. Entire Agreement This Agreement constitutes the entire agreement between the
Corporation and the Consultant and between the Corporation and the Consultant's
Designated Employee with respect to the subject matters hereof, and supersedes
any previous communications, understandings and agreements between the
Corporation and the Consultant or the Corporation and the Consultant's
Designated Employee regarding the subject matters hereof, whether written or
oral. Except as otherwise provided in this Agreement, this Agreement may only be
amended by further agreement in writing signed by the parties hereto.

IN WITNESS WHEREOF the parties have executed this Agreement with effect as of
the day and year first above written.

ASPREVA PHARMACEUTICALS CORPORATION

Per: /s/ RICHARD M. GLICKMAN
     ----------------------------------------
     Richard M. Glickman
     Chairman

GENWORKS INC.

Per: /s/ MICHAEL HAYDEN
     ---------------------------------------
     Authorized Signatory

EXECUTED by DR. MICHAEL                              )
HAYDEN in the presence of:                           )
                                                     )
S. Hayden                                            )
-----------------------------------------------------
Name                                                 )
4484 West 7th Avenue                                 )   /s/ MICHAEL HAYDEN
-----------------------------------------------------    -----------------------
Address                                              )   DR. MICHAEL HAYDEN
Vancouver V6R 1W9                                    )
-----------------------------------------------------
                                                     )
Businesswoman                                        )
-----------------------------------------------------
Occupation                                           )
                                                     )

<PAGE>

                                   SCHEDULE A

                                    SERVICES

The Consultant and the Consultant's Designated Employee shall report to the
Chief Executive Officer of the Corporation and shall devote sufficient working
time and efforts to the clinical, scientific and business affairs of the
Corporation as are necessary and consistent with the needs of the Corporation,
and in any event provide a service level to the Corporation not less than a 20%
FTE and not more than a 50% FTE. The Services to be provided by the Consultant
and the Consultant's Designated Employee are as follows:

         -        Consults on all aspects of the Corporation's drug assessment
                  and clinical development programs;

         -        Chairs the Corporation's Medical Advisory Board, consulting
                  with individual members of the Board as necessary;

         -        Consults on the recruitment of senior clinical and regulatory
                  staff;

         -        Oversees development and implementation of the Corporation's
                  search and development plans and participates in the
                  development and execution of the Corporation's overall
                  strategic plan;

         -        Consults on the development and implementation of appropriate
                  policies and procedures governing the Corporation's search and
                  development activities;

         -        Represents the Corporation in meetings with the pharmaceutical
                  industry and the scientific and business community including
                  attending conferences and meetings both within and outside of
                  Canada;

         -        Ensures that all scientific activities and operations are
                  carried out in compliance with local, provincial, federal and
                  governmental regulations and bylaws; and

         -        Any such other services as the Board of Directors of the
                  Corporation shall determine, from time to time, in accordance
                  with policies and procedures established by the Corporation.
                  At the option of the Corporation, the Consultant or and the
                  Consultant's Designated Employee may from time to time perform
                  services on behalf of the affiliates of the Corporation.

<PAGE>

                                   SCHEDULE B

                          CONFIDENTIALITY AGREEMENT AND
                            ASSIGNMENT OF INVENTIONS

                       ASPREVA PHARMACEUTICALS CORPORATION

                                                                January 28, 2002

PRIVATE AND CONFIDENTIAL

Genworks Inc.
4484 West 7th Avenue
Vancouver, British Columbia, V6R 1W9

And

Michael Hayden
4484 West 7th Avenue
Vancouver, British Columbia, V6R 1W9

The purpose of this letter is to confirm and record the terms of the agreement
(the "AGREEMENT") between you and Aspreva Pharmaceuticals Corporation
("ASPREVA") concerning the terms on which you will (i) receive from and disclose
to Aspreva proprietary and confidential information; (ii) agree to keep the
information confidential, to protect it from disclosure and to use it only in
accordance with the terms of this Agreement; and (iii) assign to Aspreva all
rights, including any ownership interest which may arise in all inventions and
intellectual property developed or disclosed by you in the performance of
consulting services with Aspreva. The effective date ("EFFECTIVE DATE") of this
Agreement is the date that you began providing services to Aspreva, as indicated
in the Consulting Agreement between Genworks Inc., Michael Hayden and Aspreva
dated as of January 28, 2002 (the "Consulting Agreement").

In consideration of the execution of the Consulting Agreement by Aspreva and the
payment by Aspreva to you of the sum of CDN$1.00 and other good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, you
and Aspreva hereby agree as follows:

1.                INTERPRETATION

1.1               DEFINITIONS.

                  In this Agreement:

         (a)      "CONFIDENTIAL INFORMATION", subject to the exemptions set out
                  in Section 2.8, shall mean any information relating to
                  Aspreva's Business (as hereinafter defined), whether or not
                  conceived, originated, discovered, or developed in whole

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                                     - 2 -

                  or in part by you, that is not generally known to the public
                  or to other persons who are not bound by obligations of
                  confidentiality and:

                  (i)      from which Aspreva derives economic value, actual or
                           potential, from the information not being generally
                           known; or

                  (ii)     in respect of which Aspreva otherwise has a
                           legitimate interest in maintaining secrecy;

                  and which, without limiting the generality of the foregoing,
                  shall include;

                  (iii)    all proprietary information licensed to, acquired,
                           used or developed by Aspreva in its research and
                           development activities including but not restricted
                           to the development and commercialization of drugs for
                           rare diseases and conditions and orphan drugs as
                           defined by U.S. Orphan Drug Act, other scientific
                           strategies and concepts, designs, know-how,
                           information, material, formulas, processes, research
                           data and proprietary rights in the nature of
                           copyrights, patents, trademarks, licenses and
                           industrial designs;

                  (iv)     all information relating to Aspreva's Business, and
                           to all other aspects of Aspreva's structure,
                           personnel, and operations, including financial,
                           clinical, regulatory, marketing, advertising and
                           commercial information and strategies, customer
                           lists, compilations, agreements and contractual
                           records and correspondence; programs, devices,
                           concepts, inventions, designs, methods, processes,
                           data, know-how, unique combinations of separate items
                           that is not generally known and items provided or
                           disclosed to Aspreva by third parties subject to
                           restrictions on use or disclosure;

                  (v)      all know-how relating to Aspreva's Business
                           including, all biological, chemical, pharmacological,
                           toxicological, pharmaceutical, physical and
                           analytical, clinical, safety, manufacturing and
                           quality control data and information, and all
                           applications, registrations, licenses,
                           authorizations, approvals and correspondence
                           submitted to regulatory authorities;

                  (vi)     all information relating to the businesses of
                           competitors of Aspreva including information relating
                           to competitors' research and development,
                           intellectual property, operations, financial,
                           clinical, regulatory, marketing, advertising and
                           commercial strategies, that is not generally known;

                  (vii)    all information provided by Aspreva's agents,
                           consultants, lawyers, contractors, licensors or
                           licensees to Aspreva and relating to Aspreva's
                           Business; and

                  (viii)   all information relating to your compensation and
                           fees, except that you shall be entitled to disclose
                           such information to your bankers, advisors, agents,
                           consultants and other third parties who have a duty
                           of confidence

<PAGE>
                                     - 3 -

                           to you and who have a need to know such information
                           in order to provide advice, products or services to
                           you.

         (b)      "INVENTIONS" shall mean any and all discoveries, developments,
                  enhancements, improvements, concepts, formulas, processes,
                  ideas, writings, whether or not reduced to practice,
                  industrial and other designs, patents, patent applications,
                  provisional patent applications, continuations,
                  continuations-in-part, substitutions, divisionals, reissues,
                  renewals, re-examinations, extensions, supplementary
                  protection certificates or the like, trade secrets or utility
                  models, copyrights and other forms of intellectual property
                  including all applications, registrations and related foreign
                  applications filed and registrations granted thereon.

         (c)      "WORK PRODUCT" shall mean any and all Inventions and possible
                  Inventions relating to Aspreva's Business resulting from any
                  work performed by you for Aspreva that you may invent or
                  co-invent during your involvement in any capacity with
                  Aspreva, except those Inventions invented by you entirely on
                  your own time that do not relate to Aspreva's Business or do
                  not derive from any equipment, supplies, facilities,
                  Confidential Information or other information, gained,
                  directly or indirectly, by you from or through your
                  involvement in any capacity with Aspreva.

         (d)      "ASPREVA'S BUSINESS" shall mean the businesses actually
                  carried on by Aspreva, directly or indirectly, whether under
                  an agreement with or in collaboration with, any other party
                  including but not exclusively, related to the development and
                  commercialization of drugs for rare diseases and conditions
                  and orphan drugs as defined by the U.S. Orphan Drug Act.

2.                CONFIDENTIALITY

2.1               BASIC OBLIGATION OF CONFIDENTIALITY.

                  You hereby acknowledge and agree that in the course of your
involvement with Aspreva, Aspreva may disclose to you or you may otherwise have
access or be exposed to Confidential Information. Aspreva hereby agrees to
provide such access to you and you agree to receive and hold all Confidential
Information on the terms and conditions set out in this Agreement. Except as set
out in this Agreement, you will keep strictly confidential all Confidential
Information and all other information belonging to Aspreva that you acquire,
observe or are informed of, directly or indirectly, in connection with your
involvement, in any capacity, with Aspreva.

2.2               FIDUCIARY CAPACITY.

                  You will be and act toward Aspreva as a fiduciary in respect
of the Confidential Information.

2.3               NON-DISCLOSURE.

<PAGE>
                                     - 4 -

                  Unless Aspreva first gives you written permission to do so
under Section 2.7 of this Agreement, you will not at any time, either during or
after your involvement in any capacity with Aspreva;

         (a)      use or copy Confidential Information or your recollections
                  thereof;

         (b)      publish or disclose Confidential Information or your
                  recollections thereof to any person other than to employees of
                  Aspreva who have a need to know such Confidential Information
                  for their work for Aspreva;

         (c)      permit or cause any Confidential Information to be used,
                  copied, published, disclosed, translated or adapted except as
                  otherwise expressly permitted by this Agreement;

         (d)      permit or cause any Confidential Information to be stored off
                  the premises of Aspreva, including permitting or causing such
                  Information to be stored in electronic format on personal
                  computers, except in accordance with written procedures of
                  Aspreva, as amended from time to time in writing; or

         (e)      communicate the Confidential Information or your recollections
                  thereof to another employee of Aspreva in a public place or
                  using methods of communication that are capable of being
                  intercepted (such as unencrypted messages using the internet
                  or cellular phones) or overheard, without the written
                  permission of Aspreva.

2.4               TAKING PRECAUTIONS.

                  You will take all reasonable precautions necessary or prudent
to prevent material in your possession or control that contains or refers to
Confidential Information from being discovered, used or copied by third parties.

2.5               ASPREVA'S OWNERSHIP OF CONFIDENTIAL INFORMATION.

                  As between you and Aspreva, Aspreva shall own all right, title
and interest in and to the Confidential Information, whether or not created or
developed by you.

2.6               CONTROL OF CONFIDENTIAL INFORMATION AND RETURN OF INFORMATION.

                  All physical materials produced or prepared by you containing
Confidential Information, including, without limitation, biological material,
chemical entities, test results, notes of experiments, computer files,
photographs, x-ray film, designs, devices, formulas, memoranda, drawings, plans,
prototypes, samples, accounts, reports, financial statements, estimates and
materials prepared in the course of your obligations to or for the benefit of
Aspreva, shall belong to Aspreva, and you will promptly turn over to Aspreva's
possession every original and copy of any and all such items in your possession
or control upon request by Aspreva. You shall not permit or cause any physical
materials to be stored off the premises of Aspreva,

<PAGE>
                                     - 5 -

unless in accordance with written procedures of Aspreva, as amended from time to
time in writing. You shall not transfer any biological material to another
person outside of Aspreva, unless a material transfer agreement has been signed
by both Aspreva and the other party. You shall not accept any biological
material from another person outside of Aspreva, unless in accordance with
written procedures of Aspreva, as amended from time to time in writing.

2.7               PURPOSE OF USE.

                  You will use Confidential Information only for purposes
authorised or directed by Aspreva.

2.8               EXEMPTIONS.

                  Your obligation of confidentiality under this Agreement will
not apply to any of the following:

         (a)      information that is already known to you, though not due to a
                  prior disclosure by Aspreva or by a person who obtained
                  knowledge of the information, directly or indirectly, from
                  Aspreva;

         (b)      information disclosed to you by another person who is not
                  obliged to maintain the confidentiality of that information
                  and who did not obtain knowledge of the information, directly
                  or indirectly, from Aspreva;

         (c)      information that is developed by you independently of
                  Confidential Information received from Aspreva and such
                  independent development can be documented by you;

         (d)      other particular information or material which Aspreva
                  expressly exempts by written instrument signed by Aspreva;

         (e)      information or material that is in the public domain through
                  no fault of your own; and

         (f)      information or material that you are obligated by law to
                  disclose, to the extent of such obligation, provided that:

                  (i)      in the event that you are required to disclose such
                           information or material, then, as soon as you become
                           aware of this obligation to disclose, you will
                           provide Aspreva with prompt written notice so that
                           Aspreva may seek a protective order or other
                           appropriate remedy and/or waive compliance with the
                           provisions of this Agreement;

                  (ii)     if Aspreva agrees that the disclosure is required by
                           law, it will give you written authorization to
                           disclose the information for the required purposes
                           only;

                  (iii)    if Aspreva does not agree that the disclosure is
                           required by law, this Agreement will continue to
                           apply, except to the extent that a Court of competent
                           jurisdiction orders otherwise; and

<PAGE>
                                     - 6 -

                  (iv)     if a protective order or other remedy is not obtained
                           or if compliance with this Agreement is waived, you
                           will furnish only that portion of the Confidential
                           Information that is legally required and will
                           exercise all reasonable efforts to obtain
                           confidential treatment of such Confidential
                           Information.

3.                ASSIGNMENT OF INTELLECTUAL PROPERTY RIGHTS

3.1               NOTICE OF INVENTION.

                  You agree to promptly and fully inform Aspreva of all your
Work Product, whether or not patentable, throughout the course of your
involvement, in any capacity, with Aspreva, whether or not developed before or
after your execution of this Agreement. On your ceasing to be employed by
Aspreva for any reason whatsoever, you will immediately deliver up to Aspreva
all of your Work Product. You further agree that all of your Work Product shall
at all times be the Confidential Information of Aspreva.

3.2               ASSIGNMENT OF RIGHTS.

                  Subject only to those exceptions set out in Exhibit A hereto,
you will assign, and do hereby assign, to Aspreva or, at the option of Aspreva
and upon notice from Aspreva, to Aspreva's designee, your entire right, title
and interest in and to all of your Work Product during your involvement, in any
capacity, with Aspreva and all other rights and interests of a proprietary
nature in and associated with your Work Product, including all patents, patent
applications filed and other registrations granted thereon. To the extent that
you retain or acquire legal title to any such rights and interests, you hereby
declare and confirm that such legal title is and will be held by you only as
trustee and agent for Aspreva. You agree that Aspreva's rights hereunder shall
attach to all of your Work Product, notwithstanding that it may be perfected or
reduced to specific form after you have terminated your relationship with
Aspreva. You further agree that Aspreva's rights hereunder are worldwide rights
and are not limited to Canada, but shall extend to every country of the world.

3.3               MORAL RIGHTS.

                  Without limiting the foregoing, you irrevocably waive any and
all moral rights arising under the Copyright Act (Canada), as amended, or any
successor legislation of similar force and effect or similar legislation in
other applicable jurisdictions or at common law that you may have with respect
to your Work Product, and agree never to assert any moral rights which you may
have in your Work Product, including, without limitation, the right to the
integrity of such Work Product, the right to be associated with the Work
Product, the right to restrain or claim damages for any distortion, mutilation
or other modification or enhancement of the Work Product and the right to
restrain the use or reproduction of the Work Product in any context and in
connection with any product, service, cause or institution, and you further
confirm that Aspreva may use or alter any such Work Product as Aspreva sees fits
in its absolute discretion.

3.4               GOODWILL.

<PAGE>
                                     - 7 -

                  You hereby agree that all goodwill you have established or may
establish with clients, customers, suppliers, principals, shareholders,
investors, collaborators, strategic partners, licensees, contacts or prospects
of Aspreva relating to the business or affairs of Aspreva (or of its partners,
subsidiaries or affiliates), both before and after the Effective Date, shall, as
between you and Aspreva, be and remain the property of Aspreva exclusively, for
Aspreva to use, alter, vary, adapt and exploit as Aspreva shall determine in its
discretion.

3.5               ASSISTANCE.

                  You hereby agree to reasonably assist Aspreva, at Aspreva's
request and expense, in:

         (a)      making patent applications for your Work Product, including
                  instructions to lawyers and/or patent agents as to the
                  characteristics of your Work Product in sufficient detail to
                  enable the preparation of a suitable patent specification, to
                  execute all formal documentation incidental to an application
                  for letters patent and to execute assignment documents in
                  favour of Aspreva for such applications;

         (b)      making applications for all other forms of intellectual
                  property registration relating to your Work Product;

         (c)      prosecuting and maintaining the patent applications and other
                  intellectual property relating to your Work Product; and

         (d)      registering, maintaining and enforcing the patents and other
                  intellectual property registrations relating to your Work
                  Product.

3.6               ASSISTANCE WITH PROCEEDINGS.

                  You further agree to reasonably assist Aspreva, at Aspreva's
request and expense, in connection with any defence to an allegation of
infringement of another person's intellectual property rights, claim of
invalidity of another person's intellectual property rights, opposition to, or
intervention regarding, an application for letters patent, copyright or
trademark or other proceedings relating to intellectual property or applications
for registration thereof.

4.                GENERAL

4.1               TERM AND DURATION OF OBLIGATION.

                  The term of this Agreement is from the Effective Date and
terminates on the date that you are no longer working at or for Aspreva. Except
as otherwise agreed in a written instrument signed by Aspreva, Article 2 shall
survive the termination of this Agreement, including your obligations of
confidentiality and to return Confidential Information, and shall endure, with
respect to each item of Confidential Information, for so long as those items
fall within the definition of Confidential Information. Sections 1.1, 3.2, 3.3,
3.4, 3.5, 3.6, 4.1, 4.2, 4.4, 4.5, 4.6, 4.7, 4.8, 4.9, 4.10, 4.11, 4.12 and 4.13
shall also survive the termination of this Agreement.

<PAGE>
                                     - 8 -

4.2               BINDING NATURE OF AGREEMENT.

                  This Agreement is not assignable by you. You agree that this
Agreement shall be binding upon your heirs and estate.

4.3               NON-COMPETITION.

                  While you are an employee of Aspreva, you will not provide
services to or enter into a contract of employment or service in any capacity
for any business which is in any way competitive with Aspreva's Business without
the prior written consent of Aspreva.

4.4               NO CONFLICTING OBLIGATIONS.

                  You represent and warrant that you will not use or disclose to
other persons at Aspreva information that (i) constitutes a trade secret of
persons other than Aspreva during your employment at Aspreva, or (ii) which is
confidential information owned by another person. You represent and warrant that
you have no agreements with or obligations to others with respect to the matters
covered by this Agreement or concerning the Confidential Information that are in
conflict with anything in this Agreement.

4.5               EQUITABLE REMEDIES.

                  You acknowledge and agree that a breach by you of any of your
obligations under this Agreement would result in damages to Aspreva that could
not be adequately compensated by monetary award. Accordingly, in the event of
any such breach by you, in addition to all other remedies available to Aspreva
at law or in equity, Aspreva shall be entitled as a matter of right to apply to
a court of competent jurisdiction for such relief by way of restraining order,
injunction, decree or otherwise, as may be appropriate to ensure compliance with
the provisions of this Agreement, without having to prove damages to the court.

4.6               PUBLICITY.

                  You shall not, without the prior written consent of Aspreva,
make or give any public announcements, press releases or statements to the
public or the press regarding your Work Product or any Confidential Information.

4.7               SEVERABILITY.

                  If any covenant or provision of this Agreement or of a section
of this Agreement is determined by a court of competent jurisdiction to be void
or unenforceable in whole or in part, then such void or unenforceable covenant
or provision shall not affect or impair the enforceability or validity of the
balance of the section or any other covenant or provision.

<PAGE>
                                     - 9 -

4.8               TIME OF ESSENCE/NO WAIVER.

                  Time is of the essence hereof and no waiver, delay,
indulgence, or failure to act by Aspreva regarding any particular default or
omission by you shall affect or impair any of Aspreva's rights or remedies
regarding that or any subsequent default or omission that is not expressly
waived in writing, and in all events time shall continue to be of the essence
without the necessity of specific reinstatement.

4.9               FURTHER ASSURANCES.

                  The parties will execute and deliver to each other such
further instruments and assurances and do such further acts as may be required
to give effect to this Agreement.

4.10              NOTICES.

                  All notices and other communications that are required or
permitted by this Agreement must be in writing and shall be hand delivered or
sent by express delivery service or certified or registered mail, postage
prepaid, or by facsimile transmission (with written confirmation copy by
registered first-class mail) to the parties at the addresses indicated below.

                  IF TO ASPREVA:

                  Aspreva Pharmaceuticals Corporation
                  Farris, Vaughan, Wills & Murphy
                  2600 - 700 West Georgia Street
                  Vancouver, B.C. V7Y 1B3
                  Attn:  R. Hector MacKay-Dunn
                  Fax:  (604) 661-9349

                  IF TO GENWORKS INC.:

                  Genworks Inc.
                  4484 7th Avenue
                  Vancouver, B.C. V6W 1W9

                  IF TO MICHAEL HAYDEN:

                  Michael Hayden
                  4484 7th Avenue
                  Vancouver, B.C. V6W 1W9

Any such notice shall be deemed to have been received on the earlier of the date
actually received or the date five (5) days after the same was posted or sent.
Either party may change its address or its facsimile number by giving the other
party written notice, delivered in accordance with this Section 4.10.

<PAGE>
                                     - 10 -

4.11              AMENDMENT.

                  No amendment, modification, supplement or other purported
alteration of this Agreement shall be binding unless it is in writing and signed
by you and by Aspreva.

4.12              ENTIRE AGREEMENT.

                  This Agreement supersedes all previous dealings,
understandings, and expectations of the parties and constitutes the whole
agreement with respect to the matters contemplated hereby, and there are no
representations, warranties, conditions or collateral agreements between the
parties with respect to such transactions except as expressly set out herein.

4.13              GOVERNING LAW.

                  This Agreement shall be governed by and interpreted in
accordance with the laws of the Province of British Columbia and applicable laws
of Canada and the parties hereto attorn to the exclusive jurisdiction of the
provincial and federal courts of such province.

4.14              INDEPENDENT LEGAL ADVICE.

                  You hereby acknowledge that you have obtained or have had an
opportunity to obtain independent legal advice in connection with this
Agreement, and further acknowledge that you have read, understand, and agree to
be bound by all of the terms and conditions contained herein.

4.15              ACCEPTANCE

                  If the foregoing terms and conditions are acceptable to you,
please indicate your acceptance of and agreement to the terms and conditions of
this Agreement by signing below on this letter and on the enclosed copy of this
letter in the space provided and by returning the enclosed copy so executed to
us. Your execution and delivery to Aspreva of the enclosed copy of this letter
will create a binding agreement between us.

Thank you for your cooperation in this matter.

Yours truly,

ASPREVA PHARMACEUTICALS CORPORATION

By: /s/ RICHARD M. GLICKMAN
    -----------------------------------------
    Authorized Signatory

<PAGE>
                                     - 11 -

Accepted and agreed to as of the 28th day of January, 2002

GENWORKS INC.

By: /s/ MICHAEL HAYDEN
    -----------------------------
    Authorized Signatory

                                            /s/ MICHAEL HAYDEN
___________________________________         ---------------------------
Witness Signature                           SIGNATURE OF MICHAEL HAYDEN
___________________________________
Witness Name
___________________________________
Occupation
___________________________________
Address

<PAGE>

                                    EXHIBIT A

                           EXCLUSION FROM WORK PRODUCT

                                      NONE.