EX-10.16





 Exhibit 10.16 

May 8, 2017 
 Anthony Coyle 

Dear Tony: 
 On behalf of Immunotolerance, Inc.
(the “Company” or “Immunotolerance”), I am pleased to offer you employment with the Company. The purpose of this letter agreement (the “Agreement”) is to set forth the terms of your employment with the Company. 

1.    You will be employed to serve on a full-time basis as Founder and Chief Executive Officer and you will serve as a
member of the Company’s Board of Directors (the “Board”), each effective August 1, 2017. You will report directly to the Board and have such duties and responsibilities as are customary for such position, plus such other duties
as may from time to time be assigned to you by the Board. You agree to devote your full business time, best efforts, skill, knowledge, attention and energies to the advancement of the Company’s business and interests and to the performance of
your duties and responsibilities as an employee of the Company; provided that you may (i) engage in charitable, educational, religious, civic and similar types of activities and (ii) serve on the board of directors of for-profit business enterprises, provided that such service is approved by the Board prior to commencement thereof (such approval not to be unreasonably withheld), to the extent that such activities are not
competitive with the Company’s business and do not inhibit or prohibit the performance of your duties hereunder. You agree to abide by the rules, regulations, personnel practices and policies of the Company and any changes therein that may be
adopted from time to time by the Company. You will perform your services under this Agreement primarily at the Company’s offices in the Boston, Massachusetts area, or at such place or places as you and the Company may agree. Notwithstanding
anything in the preceding sentence, however, you understand and agree that your employment will require travel from time to time. 

2.    Your base salary will be at the rate of $33,333.33 per monthly pay period (equivalent to an annualized base salary
of $400,000.00), subject to tax and other withholdings as required by law. Such base salary may be adjusted from time to time in accordance with normal business practice and in the sole discretion of the Board. 

3.    Following the end of each calendar year and subject to the approval of the Board (or a committee thereof), you will
be eligible for a retention and performance bonus, targeted at $175,000, based on your individual performance and the Company’s performance during the applicable calendar year, as determined by the Board in its discretion in accordance with
certain objectives to be mutually agreed upon between you and the Board each year; provided, however, that for 2017 any such bonus shall be determined on a pro-rated basis. You must be an active employee of
the Company on the date any bonus is distributed in order to be eligible for and to earn a bonus award, as it also serves as an incentive to remain employed by the Company. The Board shall determine bonus awards and make payment of bonuses, if any,
no later than March 15 of the year after the bonus year for each year of your employment. 












 4.    You may participate in any and all benefit programs that the
Company establishes and makes available to its employees or executives from time to time, provided you are eligible under (and subject to all provisions of) the plan documents governing those programs. The benefit programs made available by the
Company, and the rules, terms and conditions for participation in such benefit programs, may be changed by the Company at any time without advance notice (other than as required by such programs or under law). 

5.    You will be eligible for a maximum of five weeks of vacation per calendar year to be taken in accordance with the
standard written policies of the Company. The number of vacation days for which you are eligible shall accrue at the rate of 2.0833 days per month that you are employed during such calendar year. 

6.    Subject to the approval of the Board and the terms and conditions of the Restricted Stock Agreement, the Company
shall issue and sell to you and you shall purchase 2,000,000 shares (the “Shares”) of common stock, $.0001 par value, of the Company (“Common Stock”), at a purchase price of $.0001 per share (aggregate purchase price of $200).
The Shares will be evidenced in writing by, and subject to, the terms of the Company’s 2017 Stock Plan and the Restricted Stock Agreement provided by the Company, which agreement will include terms specifying monthly vesting over four years
with a one year cliff, repurchase option for the Company and right of first refusal for purchase of the Shares by the Company. The Restricted Stock Agreement will provide for 100% accelerated vesting in the event that your employment is terminated
by the Company without Cause (as defined below) or by you for Good Reason (as defined below) in each case within twelve (12) months following a Change of Control (as defined below). 

7.    Upon submission of appropriate documentation in accordance with Company policies, the Company will promptly pay, or
reimburse you for, all reasonable business expenses that you incur in performing your duties under this Agreement, as long as such expenses are reimbursable under the Company’s policies. Payments with respect to reimbursements of business
expenses will be made in the ordinary course in accordance with the Company’s procedures. 
 8.    If your
employment is terminated by the Company without Cause or if you terminate your employment for Good Reason, (i) the Company will pay you as severance pay an aggregate amount equivalent to twelve (12) months (the “severance pay
period”) of your then current annual base salary, less all applicable taxes and withholdings, which severance pay will be paid ratably in accordance with the Company’s regular payroll practices over a period of twelve (12) months
beginning in the Company’s first regular payroll cycle after the Release Agreement (as defined below) becomes effective; provided, however, that if the 60th day referenced below occurs in the calendar year following the date of your
termination, then the severance pay shall begin no earlier than January 1 of such subsequent calendar year; and (ii) should you timely elect and be eligible to continue receiving group medical coverage pursuant to the “COBRA”
law, and so long as the Company can provide such benefit without violating the nondiscrimination requirements of applicable law, the Company will for a period of twelve (12) months following your termination (the “benefits period”)
continue to pay the share of the premium for such coverage that is paid by the Company for active and similarly-situated employees who receive the same type of coverage (the remaining balance of any premium costs shall timely be paid by you on a
monthly basis for as long as, and to the extent that, you remain eligible for COBRA continuation). Additionally, if, within 

  
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twelve (12) months following a Change of Control, your employment is terminated by the Company without Cause or by you for Good Reason, the Company will pay you as additional severance pay
an aggregate amount equivalent to your retention and performance bonus at target for the year in which your employment is terminated, which amount will be paid in a lump sum on the first regular payroll cycle after the Release Agreement becomes
effective. To receive any of the severance benefits provided for under this paragraph of this Agreement or otherwise, you must deliver to the Company a separation agreement and general release of claims (the “Release Agreement”) in the
form the Company provides and which is reasonably acceptable to you (which shall include a release of all releasable claims, reasonable obligations to cooperate, an obligation to not disparage the Company, and reaffirmation of your obligations under
the Restrictive Covenants Agreements (as defined below)), which Release Agreement must become irrevocable within 60 days (or such earlier date as the release provides) following the date of your termination of employment. Attached as Appendix
A are the terms and conditions applicable to the payment of any severance hereunder. 
 9.    If your employment is
terminated by the Company for Cause or if you terminate your employment other than for Good Reason, the Company shall pay you your earned and accrued but unpaid cash compensation, in the form of a lump-sum
payment, to be paid not later than the next regular payroll cycle following your date of termination, which shall equal the sum of (i) any portion of your then current annual base salary earned through the date of termination that has not yet
been paid, (ii) any unpaid retention and performance bonus that was earned by you and declared due and owing by the Company and (iii) any accrued but unpaid vacation time, in each case subject to applicable taxes and withholding. The
Company shall also provide you with any other benefits (other than severance benefits) to which you are entitled under the Company’s benefit plans and arrangements as and when due under such plans and arrangements. 

10.    For purposes of this Agreement: 

“Cause” means any of: (a) your conviction of, or plea of guilty or nolo contendere to, any crime involving
dishonesty or moral turpitude or any felony; or (b) that you have (i) engaged in dishonesty, willful misconduct or gross negligence with respect to the Company or its affiliates, (ii) committed an act that materially injures or would
reasonably be expected to materially injure the reputation, business or business relationships of the Company, which act, if curable, is not cured within 30 days after delivery of written notice thereof, (iii) materially breached the terms of
any of the restrictive covenants or confidentiality agreements or any similar agreement with the Company, (iv) violated Company policies or procedures, which breach, if curable, is not cured within 30 days after delivery of written notice
thereof; and/or (v) failed to perform your assigned duties to the Board’s satisfaction, following notice of such failure by the Company and a period of 30 days to cure. 

“Change of Control” means, regardless of form thereof, consummation of (a) the sale of all or substantially all
of the assets of the Company on a consolidated basis to an unrelated person or entity, (b) a merger, reorganization or consolidation in which the outstanding shares of capital stock of the Company are converted into or exchanged for securities
of the successor entity and the holders of the Company’s outstanding voting power immediately prior to such transaction do not own a majority of the outstanding voting power of the successor entity immediately upon completion of such
transaction, (c) the sale of all or a majority of the outstanding capital stock of the Company to an unrelated person or entity or 

  
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(d) any other transaction in which the owners of the Company’s outstanding voting power immediately prior to such transaction do not own at least a majority of the outstanding voting
power of the successor entity immediately upon completion of the transaction; provided, however, that “Change of Control” shall not include any financing transaction of the Company (whether public or private) that would otherwise be and/or
trigger a “Change of Control” under (c) and/or (d) above. 
 “Good Reason” means that the
Company has engaged in any of the following without your consent: (a) a Reduction in Duties (as defined below), (b) any material and adverse breach of this Agreement by the Company, (c) relocation of the Company’s headquarters more
than fifty (50) miles from its present location or your transfer to any location more than fifty (50) miles from the location of the current headquarters or (d) any material1
reduction in your base compensation, bonus target, or benefits (other than in connection with, and in an amount substantially proportionate to, reductions made by the Company to the base salaries, bonus targets, or benefits of the other executives);
provided, that no such event shall constitute Good Reason unless (i) you provide written notice of such event to the Company within thirty (30) days of the occurrence of such event, (ii) the Company fails to cure such event within
thirty (30) days following receipt of your written notice and (iii) you actually terminate employment within thirty (30) days following the cure period. 

“Reduction in Duties” means: (i) prior to a Change of Control, a material reduction by the Company in your
duties, position, title, or responsibilities; and (ii) after a Change of Control, a material reduction by the Company in your duties and responsibilities. For the avoidance of doubt, if Immunotolerance becomes a subsidiary, division or business
unit as a result of a Change of Control and you are responsible for the leadership and/or management of that unit, this shall not be considered a Reduction in Duties. Moreover, if you receive a senior management position with the company that
survives the Change of Control with responsibilities that are approximately commensurate with your responsibilities at Immunotolerance prior to the Change of Control, then this also shall not be considered a Reduction in Duties. 

11.    In connection with signing this Agreement, and as a condition of your continued employment with the Company, you
agree to execute an Invention and Non-Disclosure Agreement and a Non-Competition and Non-Solicitation Agreement in the forms
attached as Exhibit A and Exhibit B (collectively, the “Restrictive Covenants Agreements”), which address your responsibilities to the Company in connection with confidentiality, transfer and protection of intellectual
property, noncompetition, and non-solicitation of employees and customers. 

12.    You represent that you are not bound by any employment contract, restrictive covenant or other restriction
preventing (or that purports to prevent) you from entering into employment with or carrying out your responsibilities for the Company, or which is in any way inconsistent with the terms of this letter. 

  
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 13.    You agree to provide to the Company, within three days of your
hire date, documentation of your eligibility to work in the United States, as required by the Immigration Reform and Control Act of 1986. You may need to obtain a work visa in order to be eligible to work in the United States. If that is the case,
your employment with the Company will be conditioned upon your obtaining a work visa in a timely manner as determined by the Company. 

14.    This letter shall not be construed as an agreement, either expressed or implied, to employ you for any stated term,
and shall in no way alter the Company’s policy of employment at will, under which both you and the Company remain free to terminate the employment relationship, with or without cause, at any time, with or without notice. Although your job
duties, title, compensation and benefits, as well as the Company’s personnel policies and procedures, may change from time to time, the “at-will” nature of your employment may only be changed by
a written agreement signed by you and the Board, which expressly states the intention to modify the at-will nature of your employment. Similarly, nothing in this letter shall be construed as an agreement,
either express or implied, to pay you any compensation or grant you any benefit beyond the end of your employment with the Company, except to the extent set forth in Sections 8 and 9 hereof. 

15.    The Company’s premises, including all workspaces, furniture, documents, and other tangible materials, and all
information technology resources of the Company (including computers, data and other electronic files, and all internet and email) are subject to oversight and inspection by the Company at any time. Company employees should have no expectation of
privacy with regard to any Company premises, materials, resources, or information. 
 16.    This offer letter is your
formal offer of employment and supersedes any and all prior or contemporaneous agreements, discussions and understandings, whether written or oral, relating to the subject matter of this letter or your employment with the Company. The resolution of
any disputes under this letter will be governed by the laws of the Commonwealth of Massachusetts. 
 * * * 

  
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 If you agree with the provisions of this letter, please sign the enclosed duplicate of this
letter in the space provided below and return it to me. 
 Please know that we are truly enthused at the prospect of you becoming part of
the Immunotolerance team and at your leadership helping to build what we hope will be an exceptional organization, one that is both a scientific pioneer and that delivers transformative medicines to many, many patients. We believe that you will be a
fundamental part of turning that aspiration into reality. 
  

			
	Very truly yours,
		
	By:	 	/s/ Alan Crane     
	Name:	 	Alan Crane
	Title:	 	President


 The foregoing correctly sets forth the terms of my 

employment by Immunotolerance, Inc. 
  

							
	/s/ Anthony Coyle	 		 	Date:	 	05/08/2017
	Name: Anthony Coyle	 		 		 	


  
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 APPENDIX A 

Payments Subject to Section 409A 
 1.
    Subject to this Appendix A, any severance payments that may be due under the Agreement shall begin only upon the date of your “separation from service” (determined as set forth below) which occurs on or after the
termination of your employment. The following rules shall apply with respect to distribution of the severance payments, if any, to be provided to you under the Agreement, as applicable: 

(a)    It is intended that each installment of the severance payments under the Agreement provided under shall be treated
as a separate “payment” for purposes of Section 409A. Neither the Company nor you shall have the right to accelerate or defer the delivery of any such payments except to the extent specifically permitted or required by
Section 409A. 
 (b)    If, as of the date of your “separation from service” from the Company, you are not
a “specified employee” (within the meaning of Section 409A), then each installment of the severance payments shall be made on the dates and terms set forth in the Agreement. 

(c)    If, as of the date of your “separation from service” from the Company, you are a “specified
employee” (within the meaning of Section 409A), then: 
 (i)    Each installment of the severance payments due
under the Agreement that, in accordance with the dates and terms set forth herein, will in all circumstances, regardless of when your separation from service occurs, be paid within the short-term deferral period (as defined under Section 409A)
shall be treated as a short-term deferral within the meaning of Treasury Regulation Section 1.409A-1(b)(4) to the maximum extent permissible under Section 409A and shall be paid on the dates and
terms set forth in the Agreement; and 
 (ii)    Each installment of the severance payments due under the Agreement that
is not described in this Appendix A, Section 1(c)(i) and that would, absent this subsection, be paid within the six-month period following your “separation from service” from the Company shall
not be paid until the date that is six months and one day after such separation from service (or, if earlier, your death), with any such installments that are required to be delayed being accumulated during the
six-month period and paid in a lump sum on the date that is six months and one day following your separation from service and any subsequent installments, if any, being paid in accordance with the dates and
terms set forth herein; provided, however, that the preceding provisions of this sentence shall not apply to any installment of payments if and to the maximum extent that such installment is deemed to be paid under a separation pay plan that does
not provide for a deferral of compensation by reason of the application of Treasury Regulation 1.409A-1(b)(9)(iii) (relating to separation pay upon an involuntary separation from service). Any
installments that qualify for the exception under Treasury Regulation Section 1.409A-1(b)(9)(iii) must be paid no later than the last day of your second taxable year following the taxable year in which
the separation from service occurs. 

  
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 2.    The determination of whether and when your separation from service from the
Company has occurred shall be made and in a manner consistent with, and based on the presumptions set forth in, Treasury Regulation Section 1.409A-1(h). Solely for purposes of this Appendix A,
Section 2, “Company” shall include all persons with whom the Company would be considered a single employer under Section 414(b) and 414(c) of the Internal Revenue Code of 1986, as amended (the “Code”). 

3.    Any reimbursements and in-kind benefits provided under the Agreement or otherwise that
constitute deferred compensation within the meaning of Code Section 409A shall be made or provided in accordance with the requirements of Code Section 409A, including, without limitation, that (i) in no event shall any fees, expenses
or other amounts eligible to be reimbursed by the Company under this Agreement or otherwise be paid later than the last day of the calendar year next following the calendar year in which the applicable fees, expenses or other amounts were incurred;
(ii) the amount of expenses eligible for reimbursement, or in-kind benefits that the Company is obligated to pay or provide, in any given calendar year shall not affect the expenses that the Company is
obligated to reimburse, or the in-kind benefits that the Company is obligated to pay or provide, in any other calendar year; and (iii) your right to have the Company pay or provide such reimbursements and
in-kind benefits may not be liquidated or exchanged for any other benefit. 
 4.    The Company
makes no representation or warranty and shall have no liability to you or to any other person if any of the provisions of the Agreement (including this Appendix) are determined to constitute deferred compensation subject to Section 409A but
that do not satisfy an exemption from, or the conditions of, that section. 

  
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