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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549





FORM 10-Q







|x | QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ---------------------------------------------------------------------------------------

For the quarterly period ended June 30, 2009

or



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------

Commission File Number: 000-50768





ACADIA PHARMACEUTICALS INC.

(Exact Name of Registrant as Specified in Its Charter)







|                                                     |  |                                     
|---------------------------------------------------- |  | ------------------------------------
|Delaware                                             |  | 06-1376651                          
|(State of Incorporation)                             |  | (I.R.S. Employer Identification No.)
|                                                     | 
|3911 Sorrento Valley Boulevard San Diego, California |  | 92121                               
|(Address of Principal Executive Offices)             |  | (Zip Code)                          

(858) 558-2871

(Registrants Telephone Number, Including Area Code)





Indicate by check mark whether
the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or such shorter period that the registrant was required to file such reports), and
(2) has been subject to such filing requirements for the past 90 days.    Yes  x    No   ̈

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File
required to be submitted and posted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).    Yes   ̈    No   ̈

Indicate by check mark whether
the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of large accelerated filer, accelerated filer and smaller reporting
company in Rule 12b-2 of the Securities Exchange Act of 1934.

Large accelerated filer   ̈        Accelerated filer  x        Non-accelerated filer   ̈        Smaller reporting company   ̈

(Do not check if a smaller reporting company)

Indicate by check mark whether the registrant is a
shell company (as defined in Rule 12b-2 of the Exchange Act).    Yes   ̈    No  x

Total shares of common stock outstanding as of the close of business on July 31, 2009:



|                                |  |                             
|------------------------------- |  | ----------------------------
|Class                           |  | Number of Shares Outstanding
|Common Stock, $0.0001 par value |  | 37,315,821                  









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##### Table of Contents

ACADIA PHARMACEUTICALS INC.

FORM 10-Q

TABLE OF CONTENTS



|                              |  |                                                                                                           |  |         
|----------------------------- |  | --------------------------------------------------------------------------------------------------------- |  | --------
|                              |  |                                                                                                           |  | PAGE NO.
|TABLE OF CONTENTS             |  | i                                                                                                        
|                              | 
|PART I. FINANCIAL INFORMATION |  |                                                                                                          
|                              |  |                                                                                                          
|Item 1.                       |  | Condensed Consolidated Financial Statements (Unaudited)                                                   |  | 1       
|                              |  |                                                                                                          
|                              |  | Condensed Consolidated Balance Sheets as of June 30, 2009 and December 31, 2008                           |  | 1       
|                              |  |                                                                                                          
|                              |  | Condensed Consolidated Statements of Operations for the Three and Six Months Ended June 30, 2009 and 2008 |  | 2       
|                              |  |                                                                                                          
|                              |  | Condensed Consolidated Statements of Cash Flows for the Six Months Ended June 30, 2009 and 2008           |  | 3       
|                              |  |                                                                                                          
|                              |  | Notes to Condensed Consolidated Financial Statements                                                      |  | 4       
|                              |  |                                                                                                          
|Item 2.                       |  | Managements Discussion and Analysis of Financial Condition and Results of Operations                     |  | 8       
|                              |  |                                                                                                          
|Item 3.                       |  | Quantitative and Qualitative Disclosures About Market Risk                                                |  | 16      
|                              |  |                                                                                                          
|Item 4.                       |  | Controls and Procedures                                                                                   |  | 16      
|                              | 
|PART II. OTHER INFORMATION    |  |                                                                                                          
|                              |  |                                                                                                          
|Item 1A.                      |  | Risk Factors                                                                                              |  | 17      
|                              |  |                                                                                                          
|Item 4.                       |  | Submission of Matters to a Vote of Security Holders                                                       |  | 30      
|                              |  |                                                                                                          
|Item 6.                       |  | Exhibits                                                                                                  |  | 31      
|                              | 
|SIGNATURES                    |  | 32                                                                                                       



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PART I. FINANCIAL INFORMATION



|ITEM 1. | CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (UNAUDITED)
|------- | -------------------------------------------------------

ACADIA PHARMACEUTICALS INC.

CONDENSED CONSOLIDATED BALANCE SHEETS

(in thousands, except for par value and share data)

(Unaudited)



|                                                                                                                                                                                                                          |  |              |          |   |                     |   |          |  
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------ | -------- | - | ------------------- | - | -------- | -
|                                                                                                                                                                                                                          |  | June 30,2009 |          |   | December 31,2008(1) |  
|Assets                                                                                                                                                                                                                    |  |              |          |   |                     |   |          |  
|Cash and cash equivalents                                                                                                                                                                                                 |  | $            | 17,984   |   |                     | $ | 21,171   |  
|Investment securities, available-for-sale                                                                                                                                                                                 |  |              | 48,168   |   |                     |   | 38,912   |  
|Prepaid expenses, receivables and other current assets                                                                                                                                                                    |  |              | 2,062    |   |                     |   | 2,299    |  
|                                                                                                                                                                                                                          |  |              |          |   |                     |   |          |  
|Total current assets                                                                                                                                                                                                      |  |              | 68,214   |   |                     |   | 62,382   |  
|Property and equipment, net                                                                                                                                                                                               |  |              | 1,657    |   |                     |   | 2,103    |  
|Other assets                                                                                                                                                                                                              |  |              | 192      |   |                     |   | 192      |  
|                                                                                                                                                                                                                          |  |              |          |   |                     |   |          |  
|Total assets                                                                                                                                                                                                              |  | $            | 70,063   |   |                     | $ | 64,677   |  
|                                                                                                                                                                                                                          |  |              |          |   |                     |   |          |  
|Liabilities and Stockholders Equity                                                                                                                                                                                      |  |              |          |   |                     |   |          |  
|Accounts payable                                                                                                                                                                                                          |  | $            | 3,981    |   |                     | $ | 2,283    |  
|Accrued expenses                                                                                                                                                                                                          |  |              | 7,270    |   |                     |   | 7,535    |  
|Current portion of deferred revenue                                                                                                                                                                                       |  |              | 9,125    |   |                     |   | 438      |  
|Current portion of long-term debt                                                                                                                                                                                         |  |              | 560      |   |                     |   | 795      |  
|                                                                                                                                                                                                                          |  |              |          |   |                     |   |          |  
|Total current liabilities                                                                                                                                                                                                 |  |              | 20,936   |   |                     |   | 11,051   |  
|                                                                                                                                                                                                                          |  |              |          |   |                     |   |          |  
|Long-term portion of deferred revenue                                                                                                                                                                                     |  |              | 22,280   |   |                     |   |         |  
|Other long-term liabilities                                                                                                                                                                                               |  |              | 206      |   |                     |   | 204      |  
|Long-term debt, less current portion                                                                                                                                                                                      |  |              | 228      |   |                     |   | 430      |  
|                                                                                                                                                                                                                          |  |              |          |   |                     |   |          |  
|Total liabilities                                                                                                                                                                                                         |  |              | 43,650   |   |                     |   | 11,685   |  
|                                                                                                                                                                                                                          |  |              |          |   |                     |   |          |  
|Commitments (Note 9)                                                                                                                                                                                                      |  |              |          |   |                     |   |          |  
|Stockholders equity                                                                                                                                                                                                      |  |              |          |   |                     |   |          |  
|Preferred stock, $0.0001 par value; 5,000,000 shares authorized at June 30, 2009 and December 31, 2008; no shares issued and
outstanding at June 30, 2009 and December 31, 2008                                           |  |              |         |   |                     |   |         |  
|Common stock, $0.0001 par value; 75,000,000 shares authorized at June 30, 2009 and December 31, 2008; 37,295,821 shares and
37,177,874 shares issued and outstanding at June 30, 2009 and December 31, 2008, respectively |  |              | 4        |   |                     |   | 4        |  
|Additional paid-in capital                                                                                                                                                                                                |  |              | 348,137  |   |                     |   | 346,815  |  
|Accumulated deficit                                                                                                                                                                                                       |  |              | (321,828 | ) |                     |   | (294,100 | )
|Accumulated other comprehensive income                                                                                                                                                                                    |  |              | 100      |   |                     |   | 273      |  
|                                                                                                                                                                                                                          |  |              |          |   |                     |   |          |  
|Total stockholders equity                                                                                                                                                                                                |  |              | 26,413   |   |                     |   | 52,992   |  
|                                                                                                                                                                                                                          |  |              |          |   |                     |   |          |  
|Total liabilities and stockholders equity                                                                                                                                                                                |  | $            | 70,063   |   |                     | $ | 64,677   |  
|                                                                                                                                                                                                                          |  |              |          |   |                     |   |          |  



|(1) | The condensed consolidated balance sheet at December 31, 2008 has been derived from the audited financial statements at that date but does not include all of the information
and footnotes required by accounting principles generally accepted in the United States for complete financial statements.
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

The accompanying notes are an integral part of these condensed consolidated financial statements.



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ACADIA PHARMACEUTICALS INC.

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(in thousands, except per share data)

(Unaudited)



|                                                                                                          |  |                            |         |   |                          |   |         |      |  |   |         |   |  |   |         |  
|--------------------------------------------------------------------------------------------------------- |  | -------------------------- | ------- | - | ------------------------ | - | ------- | ---- |  | - | ------- | - |  | - | ------- | -
|                                                                                                          |  | Three Months EndedJune 30, |         |   | Six Months EndedJune 30, |  
|                                                                                                          |  | 2009                       |         |   | 2008                     |   |         | 2009 |  |   | 2008    |  
|Revenues                                                                                                  |  |                            |         |   |                          |   |         |      |  |   |         |   |  |   |         |  
|Collaborative revenues                                                                                    |  | $                          | 1,820   |   |                          | $ | 177     |      |  | $ | 2,194   |   |  | $ | 983     |  
|                                                                                                          |  |                            |         |   |                          |   |         |      |  |   |         |   |  |   |         |  
|Operating expenses                                                                                        |  |                            |         |   |                          |   |         |      |  |   |         |   |  |   |         |  
|Research and development (includes stock-based compensation of $283, $380, $504 and $795, respectively)   |  |                            | 11,979  |   |                          |   | 16,036  |      |  |   | 24,533  |   |  |   | 31,207  |  
|General and administrative (includes stock-based compensation of $333, $431, $687 and $852, respectively) |  |                            | 2,662   |   |                          |   | 3,184   |      |  |   | 5,649   |   |  |   | 6,454   |  
|                                                                                                          |  |                            |         |   |                          |   |         |      |  |   |         |   |  |   |         |  
|Total operating expenses                                                                                  |  |                            | 14,641  |   |                          |   | 19,220  |      |  |   | 30,182  |   |  |   | 37,661  |  
|                                                                                                          |  |                            |         |   |                          |   |         |      |  |   |         |   |  |   |         |  
|Loss from operations                                                                                      |  |                            | (12,821 | ) |                          |   | (19,043 | )    |  |   | (27,988 | ) |  |   | (36,678 | )
|Interest income                                                                                           |  |                            | 117     |   |                          |   | 802     |      |  |   | 308     |   |  |   | 2,109   |  
|Interest expense                                                                                          |  |                            | (24     | ) |                          |   | (46     | )    |  |   | (48     | ) |  |   | (98     | )
|                                                                                                          |  |                            |         |   |                          |   |         |      |  |   |         |   |  |   |         |  
|Net loss                                                                                                  |  | $                          | (12,728 | ) |                          | $ | (18,287 | )    |  | $ | (27,728 | ) |  | $ | (34,667 | )
|                                                                                                          |  |                            |         |   |                          |   |         |      |  |   |         |   |  |   |         |  
|Net loss per common share, basic and diluted                                                              |  | $                          | (0.34   | ) |                          | $ | (0.49   | )    |  | $ | (0.75   | ) |  | $ | (0.94   | )
|                                                                                                          |  |                            |         |   |                          |   |         |      |  |   |         |   |  |   |         |  
|Weighted average common shares outstanding, basic and diluted                                             |  |                            | 37,220  |   |                          |   | 37,102  |      |  |   | 37,200  |   |  |   | 37,077  |  
|                                                                                                          |  |                            |         |   |                          |   |         |      |  |   |         |   |  |   |         |  

The accompanying notes are an integral part of these condensed consolidated financial statements.



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ACADIA PHARMACEUTICALS INC.

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(in thousands)

(Unaudited)



|                                                                                          |  |                          |         |   |      |   |         |  
|----------------------------------------------------------------------------------------- |  | ------------------------ | ------- | - | ---- | - | ------- | -
|                                                                                          |  | Six Months EndedJune 30, |        
|                                                                                          |  | 2009                     |         |   | 2008 |  
|Cash flows from operating activities                                                      |  |                          |         |   |      |   |         |  
|Net loss                                                                                  |  | $                        | (27,728 | ) |      | $ | (34,667 | )
|Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |                          |         |   |      |   |         |  
|Depreciation and amortization                                                             |  |                          | 448     |   |      |   | 554     |  
|Stock-based compensation                                                                  |  |                          | 1,191   |   |      |   | 1,647   |  
|Amortization of investment premium/discount                                               |  |                          | 153     |   |      |   | 124     |  
|Other                                                                                     |  |                          | (4      | ) |      |   |        |  
|Changes in operating assets and liabilities:                                              |  |                          |         |   |      |   |         |  
|Prepaid expenses, receivables and other current assets                                    |  |                          | 314     |   |      |   | 984     |  
|Other assets                                                                              |  |                          | (2      | ) |      |   | 22      |  
|Accounts payable                                                                          |  |                          | 1,695   |   |      |   | 586     |  
|Accrued expenses                                                                          |  |                          | (329    | ) |      |   | (5,514  | )
|Deferred revenue                                                                          |  |                          | 30,967  |   |      |   | (537    | )
|Other long-term liabilities                                                               |  |                          | 2       |   |      |   | 47      |  
|                                                                                          |  |                          |         |   |      |   |         |  
|Net cash provided by (used in) operating activities                                       |  |                          | 6,707   |   |      |   | (36,754 | )
|                                                                                          |  |                          |         |   |      |   |         |  
|Cash flows from investing activities                                                      |  |                          |         |   |      |   |         |  
|Purchases of investment securities                                                        |  |                          | (35,209 | ) |      |   | (47,576 | )
|Maturities of investment securities                                                       |  |                          | 25,601  |   |      |   | 87,739  |  
|Purchases of property and equipment                                                       |  |                          | (7      | ) |      |   | (152    | )
|                                                                                          |  |                          |         |   |      |   |         |  
|Net cash provided by (used in) investing activities                                       |  |                          | (9,615  | ) |      |   | 40,011  |  
|                                                                                          |  |                          |         |   |      |   |         |  
|Cash flows from financing activities                                                      |  |                          |         |   |      |   |         |  
|Proceeds from issuance of common stock                                                    |  |                          | 131     |   |      |   | 476     |  
|Repayments of long-term debt                                                              |  |                          | (437    | ) |      |   | (522    | )
|                                                                                          |  |                          |         |   |      |   |         |  
|Net cash used in financing activities                                                     |  |                          | (306    | ) |      |   | (46     | )
|                                                                                          |  |                          |         |   |      |   |         |  
|Effect of exchange rate changes on cash                                                   |  |                          | 27      |   |      |   | 87      |  
|                                                                                          |  |                          |         |   |      |   |         |  
|Net increase (decrease) in cash and cash equivalents                                      |  |                          | (3,187  | ) |      |   | 3,298   |  
|Cash and cash equivalents                                                                 |  |                          |         |   |      |   |         |  
|Beginning of period                                                                       |  |                          | 21,171  |   |      |   | 16,987  |  
|                                                                                          |  |                          |         |   |      |   |         |  
|End of period                                                                             |  | $                        | 17,984  |   |      | $ | 20,285  |  
|                                                                                          |  |                          |         |   |      |   |         |  
|Supplemental schedule of noncash investing and financing activities                       |  |                          |         |   |      |   |         |  
|Unrealized loss on investment securities                                                  |  | $                        | (204    | ) |      | $ | (248    | )

The accompanying notes are an integral part of these condensed consolidated financial statements.



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ACADIA PHARMACEUTICALS INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

June 30, 2009

(Unaudited)

1. Basis of Presentation

The accompanying unaudited condensed consolidated financial statements of
ACADIA Pharmaceuticals Inc. (together with its wholly owned subsidiaries, ACADIA Pharmaceuticals AB and ACADIA Pharmaceuticals A/S, the Company) should be read in conjunction with the audited financial statements and notes thereto as of
and for the year ended December 31, 2008 included in the Companys Annual Report on Form 10-K (Annual Report) filed with the Securities and Exchange Commission (the SEC). The accompanying financial statements have
been prepared in accordance with accounting principles generally accepted in the United States (GAAP) for interim financial information and in accordance with the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly,
since they are interim statements, the accompanying financial statements do not include all of the information and notes required by GAAP for complete financial statements. In the opinion of management, the accompanying financial statements reflect
all adjustments (consisting of normal recurring adjustments) that are necessary for a fair statement of the financial position, results of operations and cash flows for the interim periods presented. Interim results are not necessarily indicative of
results for a full year. The Company evaluated all events or transactions that occurred after June 30, 2009 up through August 5, 2009, the date the Company issued these financial statements. During this period, the Company did not have any
material recognizable or nonrecognizable subsequent events. The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the amounts reported in the financial statements and the
accompanying notes. Actual results could differ from those estimates.

The Company has not been profitable and has incurred substantial
operating losses since its inception due in large part to expenditures for its research and development activities. At June 30, 2009, the Company had an accumulated deficit of $321.8 million. The Company expects its operating losses to continue
for at least the next several years as it pursues the development of its product candidates.

The Company will require significant
additional financing in the future to fund its operations. Future capital requirements will depend on many factors, including the progress in and the costs of the Companys clinical trials, the scope, prioritization and number of its
research and development programs, and the ability of its collaborators and the Company to reach the milestones, and other events or developments, under its collaboration agreements. Until the Company can generate significant continuing revenues, it
expects to fund its operations through its existing cash, cash equivalents and investment securities, payments from existing and potential future collaborations, proceeds from private or public sales of its securities, debt financing, or by
licensing all or a portion of its product candidates or technology. The Company cannot be certain that funding will be available in the future on acceptable terms, or at all. Turmoil in the financial markets could have a material adverse effect on
the Companys ability to access sufficient funding on acceptable terms, or at all. If the Company cannot raise adequate additional capital, it will be required to delay, further reduce the scope of, or eliminate one or more of its research or
development programs or its commercialization efforts.

2. Earnings (Loss) Per Share

Basic earnings (loss) per common share is computed by dividing net income (loss) by the weighted average number of common shares outstanding for the
period. Diluted earnings (loss) per common share is computed by dividing net income (loss) by the weighted average number of common shares outstanding during the period increased to include potential dilutive common shares that were outstanding
during the period. The effect of outstanding stock options and warrants, when dilutive, is reflected in diluted earnings (loss) per common share by application of the treasury stock method. The Company has excluded all outstanding stock options and
warrants from the calculation of diluted net loss per common share because all such securities are antidilutive for all periods presented.

Shares used in calculating basic and diluted net loss per common share exclude these potential common shares (in thousands):



|                                               |  |                            |  |                          |  |       |  |      
|---------------------------------------------- |  | -------------------------- |  | ------------------------ |  | ----- |  | -----
|                                               |  | Three Months EndedJune 30, |  | Six Months EndedJune 30,
|                                               |  | 2009                       |  | 2008                     |  | 2009  |  | 2008 
|                                               |  | (unaudited)                |  | (unaudited)             
|Antidilutive options to purchase common stock  |  | 3,751                      |  | 3,293                    |  | 3,694 |  | 3,134
|Antidilutive warrants to purchase common stock |  | 1,743                      |  | 1,393                    |  | 1,743 |  | 1,393
|                                               |  |                            |  |                          |  |       |  |      
|                                               |  | 5,494                      |  | 4,686                    |  | 5,437 |  | 4,527
|                                               |  |                            |  |                          |  |       |  |      



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3. Stock-Based Compensation

During the three and six months ended June 30, 2009 and the three and six months ended June 30, 2008, the Company recorded stock-based compensation expense related to employee and non-employee stock option
awards and its employee stock purchase plan of $616,000, $1.2 million, $811,000 and $1.6 million, respectively. The Company accounts for stock-based compensation expense in accordance with Statement of Financial Accounting Standards
(SFAS) No. 123 (revised 2004), Share-Based Payment. The Company accounts for stock-based compensation expense for options granted to non-employees other than directors in accordance with SFAS No. 123, Accounting for
Stock-Based Compensation, and Emerging Issues Task Force, Issue No. 96-18, Accounting for Equity Instruments that are Issued to Other than Employees for Acquiring, or in Conjunction with Selling, Goods or Services. At June 30,
2009, total unrecognized compensation cost related to unvested stock-based awards and employee stock purchase plan rights was $4.1 million, which is expected to be recognized over a weighted-average period of 2.5 years.

4. Comprehensive Loss

Comprehensive loss consisted
of the following (in thousands):



|                                                     |  |                            |         |   |                          |   |         |      |  |   |         |   |  |   |         |  
|---------------------------------------------------- |  | -------------------------- | ------- | - | ------------------------ | - | ------- | ---- |  | - | ------- | - |  | - | ------- | -
|                                                     |  | Three Months EndedJune 30, |         |   | Six Months EndedJune 30, |  
|                                                     |  | 2009                       |         |   | 2008                     |   |         | 2009 |  |   | 2008    |  
|                                                     |  | (unaudited)                |         |   | (unaudited)              |  
|Net loss                                             |  | $                          | (12,728 | ) |                          | $ | (18,287 | )    |  | $ | (27,728 | ) |  | $ | (34,667 | )
|Unrealized loss on investment securities, net of tax |  |                            | (62     | ) |                          |   | (382    | )    |  |   | (204    | ) |  |   | (248    | )
|Foreign currency translation gain, net of tax        |  |                            | 70      |   |                          |   | 22      |      |  |   | 31      |   |  |   | 62      |  
|                                                     |  |                            |         |   |                          |   |         |      |  |   |         |   |  |   |         |  
|Total comprehensive loss                             |  | $                          | (12,720 | ) |                          | $ | (18,647 | )    |  | $ | (27,901 | ) |  | $ | (34,853 | )
|                                                     |  |                            |         |   |                          |   |         |      |  |   |         |   |  |   |         |  

5. Accrued Expenses

Accrued expenses consisted of the following (in thousands):



|                                       |  |              |       |                  |   |      
|-------------------------------------- |  | ------------ | ----- | ---------------- | - | -----
|                                       |  | June 30,2009 |       | December 31,2008
|                                       |  | (unaudited) 
|Accrued clinical and research services |  | $            | 5,153 |                  | $ | 5,494
|Accrued compensation and benefits      |  |              | 1,506 |                  |   | 1,434
|Other                                  |  |              | 611   |                  |   | 607  
|                                       |  |              |       |                  |   |      
|Total                                  |  | $            | 7,270 |                  | $ | 7,535
|                                       |  |              |       |                  |   |      

6. Segment Information

Management has determined that the Company operates in one business segment. All revenues for the three and six months ended June 30, 2009 and 2008 were generated in the United States. Information regarding
long-lived assets by geographic area as of the dates indicated were as follows (in thousands):



|              |  |              |       |                  |   |      
|------------- |  | ------------ | ----- | ---------------- | - | -----
|              |  | June 30,2009 |       | December 31,2008
|              |  | (unaudited) 
|United States |  | $            | 1,222 |                  | $ | 1,537
|Europe        |  |              | 435   |                  |   | 566  
|              |  |              |       |                  |   |      
|Total         |  | $            | 1,657 |                  | $ | 2,103
|              |  |              |       |                  |   |      



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7. Fair Value Measurements

The Company adopted SFAS No. 157, Fair Value Measurements (SFAS 157), effective January 1, 2008. SFAS 157 is applicable for all financial assets and liabilities and any other
assets and liabilities that are recognized or disclosed at fair value on a recurring basis. SFAS 157 defines fair value, establishes a framework for measuring fair value in generally accepted accounting principles and expands disclosures about fair
value measurements. SFAS 157 requires fair value measurements be classified and disclosed in one of the following three categories:

Level 1.Quoted prices in active markets for identical assets or liabilities that the Company has the ability to access at the measurement date.

Level 2. Inputs other than quoted prices in active markets that are observable for the asset or liability, either directly or indirectly.

Level 3.Inputs that are unobservable for the asset or liability.

As of June 30, 2009, the Company held $65.2 million of cash equivalents and available-for-sale investment securities consisting of a money market fund wholly-backed by U.S. Treasury collateral, U.S. Treasury
notes and high quality, marketable debt instruments of corporations, financial institutions, and government sponsored enterprises. The Company has adopted an investment policy and established guidelines relating to credit quality, diversification
and maturities of its investments to preserve principal and maintain liquidity. All investment securities have a credit rating of at least AA or A1+/P1 as determined by Moodys Investors Service and/or Standard & Poors. The
Company does not have any direct investments in auction-rate securities or securities that are collateralized by assets that include mortgages or subprime debt.

The Companys cash equivalents and available-for-sale investment securities are classified within Level 1 or Level 2 of the fair value hierarchy. The Companys investment securities classified as Level 1 are
valued using quoted market prices and the Companys investment securities classified as Level 2 are valued using other observable inputs such as recent trades for the securities or similar securities, interest rates on similar securities, or
yield curves or benchmark interest rates observable at commonly quoted intervals. The fair value measurements of the Companys cash equivalents and available-for-sale investment securities are identified in the following hierarchy (in
thousands):



|                                                            |  |              |        |                                                           |   |                                           |  |                                        |        |  |   |  
|----------------------------------------------------------- |  | ------------ | ------ | --------------------------------------------------------- | - | ----------------------------------------- |  | -------------------------------------- | ------ |  | - | -
|                                                            |  |              |        | Fair Value Measurements atReporting Date using           
|                                                            |  | June 30,2009 |        | Quoted Pricesin ActiveMarkets forIdenticalAssets(Level 1) |   | SignificantOtherObservableInputs(Level 2) |  | SignificantUnobservableInputs(Level 3)
|Money market fund wholly-backed by U.S. Treasury collateral |  | $            | 17,074 |                                                           | $ | 17,074                                    |  | $                                      |       |  | $ | 
|U.S. Treasury notes                                         |  |              | 5,832  |                                                           |   | 5,832                                     |  |                                        |       |  |   | 
|Government sponsored enterprises                            |  |              | 29,840 |                                                           |   |                                          |  |                                        | 29,840 |  |   | 
|Corporate debt securities                                   |  |              | 2,500  |                                                           |   |                                          |  |                                        | 2,500  |  |   | 
|Commercial paper                                            |  |              | 9,995  |                                                           |   |                                          |  |                                        | 9,995  |  |   | 
|                                                            |  |              |        |                                                           |   |                                           |  |                                        |        |  |   |  
|                                                            |  | $            | 65,241 |                                                           | $ | 22,906                                    |  | $                                      | 42,335 |  | $ | 
|                                                            |  |              |        |                                                           |   |                                           |  |                                        |        |  |   |  

8. Collaboration and License Agreements

In May 2009, the Company entered into a collaboration and license agreement with Biovail Laboratories International SRL (Biovail), a
subsidiary of Biovail Corporation, to co-develop and commercialize pimavanserin for neurological and psychiatric indications, including Parkinsons disease psychosis (PDP) and Alzheimers disease psychosis (ADP), in
the United States and Canada. The Company has retained the rights to pimavanserin in the rest of the world. Under the terms of the agreement, the Company is entitled to receive aggregate payments, excluding royalties, of up to $395 million. These
include an upfront cash payment of $30 million, up to $160 million in potential milestone payments associated with the successful completion of clinical trials, regulatory submissions and approvals of pimavanserin for PDP and ADP, up to $45 million
in potential milestones should the parties pursue a third indication, and up to $160 million in potential milestones as certain sales thresholds are met. The Company is also entitled to receive a 15 percent royalty on annual net sales of
pimavanserin up to $100 million and a 20 percent royalty on annual net sales over $100 million. In addition to product royalties, the Company has the option to co-promote pimavanserin in the United States. Biovail is responsible for all future costs
associated with the development, manufacturing, and commercialization of pimavanserin in all indications with the exception of specified ongoing PDP studies, which will continue to be funded by the Company.



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The upfront cash payment of $30 million has been deferred and is being recognized as revenue on a
straight-line basis over the estimated period of the Companys performance under the agreement. Payments received from Biovail for the reimbursement of specified development costs have been deferred and are being recognized as revenue using a
contingency-adjusted performance model over the estimated period of the Companys performance. The Company recognized revenues relating to this collaboration of $1.4 million for the period from the effective date of the agreement on May 1,
2009 through June 30, 2009. At June 30, 2009, $28.9 million of revenue was deferred under this agreement, of which $8.5 million was included in current liabilities and $20.4 million was included in long-term liabilities.

In March 2009, the Company entered into a collaboration and license agreement with Meiji Seika Kaisha, Ltd. to develop and commercialize a novel class of
pro-cognitive drugs (PCAPs) to treat patients with schizophrenia and related disorders in Japan and several other Asian countries. Under the agreement, the Company is eligible to receive up to $25 million in aggregate payments, including
$3 million in license fees and up to $22 million in potential development and regulatory milestone payments, in addition to royalties on product sales, if any, in the Asian territory. Meiji Seika is responsible for the first $15 million of
development expenses and the companies will share remaining expenses through clinical proof-of-concept, subject to possible adjustment in the event the Company further licenses the PCAPs outside of the Asian territory. Meiji Seika is responsible for
all costs associated with the development, manufacturing and commercialization of the product in the Asian territory after proof-of-concept. Meiji Seika is eligible to share a portion of any product-related revenues received by the Company in the
rest of the world.

In April 2009, the Company received an aggregate of $2 million in license fees pursuant to the agreement with Meiji
Seika, which has been deferred and is being recognized as revenue ratably over the estimated period of the Companys performance under the agreement. Payments received from Meija Seika for the reimbursement of specified development costs have
been deferred and are being recognized as revenue using a contingency-adjusted performance model over the estimated period of the Companys performance. The Company recognized revenues relating to this collaboration of $53,000 for the three and
six months ended June 30, 2009. At June 30, 2009, $2.1 million of revenue was deferred under this agreement, of which $212,000 was included in current liabilities and $1.9 million was included in long-term liabilities.

9. Commitments

The Company has entered into
agreements with contract research organizations and other external service providers for services in connection with the development of its product candidates. The Company was contractually obligated for up to approximately $19.0 million of future
services under these agreements as of June 30, 2009, the majority of which are expected to be provided by the end of December 2010. The nature of the work being conducted under the Companys agreements with contract research organizations
is such that, in most cases, the services may be stopped with short notice. In such event, the Company would not be liable for the full amount of the contract. The Companys actual contractual obligations may vary depending upon several
factors, including the progress and results of the underlying studies.

10. Recent Accounting Pronouncements

In April 2009, the Financial Accounting Standards Board (FASB) issued three FASB Staff Positions (FSPs): (i) FSP FAS
157-4, Determining Fair Value When the Volume and Level of Activity for the Asset or Liability have Significantly Decreased and Identifying Transactions That Are Not Orderly, (ii) FSP FAS 115-2 and FAS 124-2, Recognition and
Presentation of Other-Than-Temporary Impairments, and (iii) FSP FAS 107-1 and APB 28-1, Interim Disclosures about Fair Value of Financial Instruments, which are effective for interim and annual periods ending after June 15,
2009. FSP FAS 157-4 provides additional guidance in determining fair value when market transactions are not orderly. FSP FAS 115-2 and FAS 124-2 provide additional guidance in determining when an other-than-temporary impairment of a debt security
has occurred as well as the related recognition and disclosure requirements. FSP FAS 107-1 and APB 28-1 is an amendment to FAS 107 and APB 28 in order to require disclosure about fair value of financial instruments in both interim and annual
reporting periods. The Company adopted all three FSPs for the quarter ended June 30, 2009. The adoption of these FSPs did not impact the Companys consolidated financial statements.

In April 2009, the FASB issued SFAS No. 165, Subsequent Events (SFAS 165). SFAS 165 establishes general standards of accounting
for and disclosure of events that occur after the balance sheet date but before financial statements are issued or available to be issued. The Company adopted SFAS 165 for the quarter ended June 30, 2009. The adoption of SFAS 165 did not impact
the Companys consolidated financial statements.

In June 2009, the FASB issued SFAS No. 166, Accounting for Transfers of
Financial Assets, an amendment to SFAS No. 140(SFAS 166). SFAS 166 eliminates the concept of a qualifying special-purpose entity, changes the requirements for derecognizing financial assets, and requires
additional disclosures in order to enhance information reported to users of financial statements by



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providing greater transparency about transfers of financial assets, including securitization transactions, and an entitys continuing involvement in and
exposure to the risks related to transferred financial assets. SFAS 166 is effective for fiscal years beginning after November 15, 2009. The Company is currently evaluating the potential impact of SFAS 166 on its consolidated financial
statements.

In June 2009, the FASB issued SFAS No. 167, Amendments to FASB Interpretation No. 46(R)(SFAS
167). SFAS 167 amends Interpretation 46(R) to eliminate the quantitative approach previously required for determining the primary beneficiary of a variable interest entity and other related changes. SFAS 167 is effective for fiscal years
beginning after November 15, 2009, for interim periods within that first annual reporting period, and for interim and annual reporting periods thereafter. The Company is currently evaluating the potential impact of SFAS 167 on its consolidated
financial statements.

In June 2009, the FASB issued SFAS No. 168, The FASB Accounting Standards Codification and the Hierarchy of
Generally Accepted Accounting Principles(SFAS 168). SFAS 168 replaces FASB Statement No. 162, The Hierarchy of Generally Accepted Accounting Principles, and establishes the FASB Accounting Standards Codification as the
source of authoritative GAAP recognized by the FASB to be applied by nongovernmental entities. SFAS 168 is effective for interim and annual periods ending after September 15, 2009. SFAS 168 will not have an impact on the Companys
consolidated financial statements.



|ITEM 2. | MANAGEMENTS DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS
|------- | -------------------------------------------------------------------------------------

The following discussion and analysis of our consolidated financial condition and results of operations should be read in conjunction with our unaudited
condensed consolidated financial statements and related notes included in this quarterly report on Form 10-Q (this Quarterly Report) and the audited financial statements and notes thereto as of and for the year ended December 31,
2008 included with our annual report on Form 10-K (Annual Report) filed with the SEC. Past operating results are not necessarily indicative of results that may occur in future periods.

This Quarterly Report contains forward-looking statements. These forward-looking statements involve a number of risks and uncertainties. Such
forward-looking statements include statements about our strategies, objectives, expectations, discoveries, collaborations, clinical trials, product candidates, programs, and other statements that are not historical facts, including statements which
may be preceded by the words intends, may, will, plans, expects, anticipates, projects, predicts, estimates, aims,
believes, hopes, potential or similar words. For such statements, we claim the protection of the Private Securities Litigation Reform Act of 1995. Readers of this Quarterly Report are cautioned not to place undue
reliance on these forward-looking statements, which speak only as of the date on which they are made. We undertake no obligation to update publicly or revise any forward-looking statements. Actual events or results may differ materially from our
expectations. Important factors that could cause actual results to differ materially from those stated or implied by our forward-looking statements include, but are not limited to, the risk factors identified in our filings with the SEC, including
this Quarterly Report.

Overview

Background

We are a biopharmaceutical company focused on the development and commercialization of small molecule drugs for the treatment of
central nervous system disorders. We currently are developing a portfolio consisting of our five most advanced product candidates including pimavanserin, which is in Phase III development for Parkinsons disease psychosis in collaboration with
Biovail Laboratories International SRL (Biovail), a subsidiary of Biovail Corporation. In addition to pimavanserin, we have a product candidate in Phase II development for chronic pain and a product candidate in Phase I development for
glaucoma, each in collaboration with Allergan, Inc., as well as two programs in IND-track development. All of the product candidates in our pipeline emanate from discoveries made using our proprietary drug discovery platform.

We have incurred substantial operating losses since our inception due in large part to expenditures for our research and development activities. In
August 2008, we implemented a strategic restructuring designed to focus resources primarily on our most advanced product candidates, including pimavanserin, and to provide additional financial flexibility and strength. At June 30, 2009, we had
an accumulated deficit of $321.8 million. Although we have reduced our operating expenses in connection with the strategic restructuring, we expect our operating losses to continue for at least the next several years as we pursue the clinical
development of our product candidates.



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We maintain a website at www.acadia-pharm.com to which we regularly post copies of our press releases as
well as additional information about us. Our filings with the SEC are available free of charge through our website as soon as reasonably practicable after being electronically filed with or furnished to the SEC. Interested persons can subscribe on
our website to email alerts that are sent automatically when we issue press releases, file our reports with the SEC or post certain other information to our website. Information contained in our website does not constitute a part of this Quarterly
Report.

Recent Developments

In
May 2009, we announced the completion of enrollment in our first pivotal Phase III clinical trial of pimavanserin in patients with Parkinsons disease psychosis. Top-line results from this trial are expected to be announced in the third quarter
of 2009.

In May 2009, we entered into a collaboration agreement with Biovail to co-develop and commercialize pimavanserin for
neurological and psychiatric indications, including Parkinsons disease psychosis (PDP) and Alzheimers disease psychosis (ADP), in the United States and Canada. We have retained the rights to pimavanserin in the
rest of the world. Under the terms of the agreement, we are entitled to receive aggregate payments, excluding royalties, of up to $395 million. These include an upfront cash payment of $30 million, up to $160 million in potential milestone payments
associated with the successful completion of clinical trials, regulatory submissions and approvals of pimavanserin for PDP and ADP, up to $45 million in potential milestones should the parties pursue a third indication, and up to $160 million in
potential milestones as certain sales thresholds are met. We also are entitled to receive a 15 percent royalty on annual net sales of pimavanserin up to $100 million and a 20 percent royalty on annual net sales over $100 million. In addition to
product royalties, we have the option to co-promote pimavanserin in the United States. Biovail will be responsible for all future costs associated with the development, manufacturing, and commercialization of pimavanserin in all indications with the
exception of specified ongoing PDP studies, which we will continue to fund.

In April 2009, we entered into an amendment to extend the
research term of our March 2003 collaboration with Allergan. This collaboration originally provided for a three-year research term, which ended in March 2006. The parties previously had extended the research term through March 2009. The most recent
amendment extends the research term for one additional year, through March 2010. During the extended research term, the parties will focus joint research efforts on discovery activities in ophthalmic indications.

Revenues

We have not generated any revenues
from product sales to date, and we do not expect to generate revenues from product sales for at least the next several years, if at all. Our revenues to date have been generated substantially from payments under our current and past collaboration
agreements. As of June 30, 2009, we had received an aggregate of $92.5 million in payments under these agreements, including upfront payments, research funding, and milestone payments. We expect our revenues for the next several years to
consist primarily of payments under our current agreements with Biovail, Allergan, and Meiji Seika Kaisha, Ltd. and potential additional collaborations.

In May 2009, we entered into a collaboration agreement with Biovail, pursuant to which we received a $30 million upfront payment. Under the terms of the agreement, we are entitled to receive additional payments of up
to an aggregate of $365 million upon successfully achieving development, regulatory and sales milestones. We also are entitled to receive royalties on annual net sales of pimavanserin. Our agreement with Biovail is subject to early termination upon
specified events.

We currently are a party to three separate collaboration agreements with Allergan. Pursuant to our March 2003
collaboration agreement with Allergan, we had received an aggregate of $15.9 million in payments as of June 30, 2009, consisting of upfront fees, research funding and related fees. This collaboration originally provided for a three-year
research term, which has been extended by the parties through March 2010. We have had a reduced level of research activities and related research funding under this collaboration during the extension. In our two other collaboration agreements with
Allergan, the parties are currently pursuing the clinical development of product candidates in the areas of chronic pain and glaucoma. We are eligible to receive payments upon achievement of development and regulatory milestones, as well as
royalties on product sales, if any, under each of our three collaboration agreements with Allergan. Each of our agreements with Allergan is subject to early termination upon specified events, including, in the case of one of our agreements, if we
have a change in control. Upon the conclusion of the research term under each agreement, Allergan may terminate the agreement by notice.

In March 2009, we entered into a collaboration agreement with Meiji Seika, pursuant to which we received an aggregate of $2 million in license fees in April 2009. Under the agreement, we are eligible to receive up to $25 million in
aggregate payments, including the $2 million in license fees already received, in addition to royalties on product sales, if any, in the Asian territory. Meiji Seika also is responsible for the first $15 million of development expenses and we
will share the remaining expenses through clinical proof-of-concept, subject to possible adjustment in the event we further license the related product candidate outside of the Asian territory. Our agreement with Meiji Seika is subject to early
termination upon specified events.



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Research and Development Expenses

Our research and development expenses consist primarily of fees paid to external service providers, salaries and related personnel expenses, facilities
and equipment expenses, and supplies and other costs. We charge all research and development expenses to operations as incurred. Our research and development activities are primarily focused on our most advanced product candidates, including
pimavanserin.

Prior to our collaboration with Biovail, which we established in May 2009, we were responsible for all costs incurred in the
development of pimavanserin as well as the costs associated with our other internal programs. Pursuant to this agreement, Biovail is responsible for all future costs associated with the development of pimavanserin in all indications with the
exception of specified ongoing PDP studies, which will continue to be funded by ACADIA. These ongoing studies include our pivotal Phase III trials and related open-label safety extension study. Pursuant to our collaboration with Meiji Seika, which
we established in March 2009, Meiji Seika is responsible for the first $15 million of development expenses for the product candidate, AM-831, and the companies will share remaining expenses through clinical proof-of-concept, subject to possible
adjustment. Meiji Seika is responsible for all costs associated with the development of AM-831 in the Asian territory after proof-of-concept. We are not responsible for, nor have we incurred, development expenses related to our product candidates,
including costs related to clinical trials, in our clinical programs for chronic pain and glaucoma, which we are pursuing in collaboration with Allergan.

We use our internal research and development resources, including our employees and discovery infrastructure, across several projects and many of our costs are not attributable to a specific project but are directed
to broadly applicable research activities. Accordingly, we do not report our internal research and development costs on a project basis. We use external service providers to manufacture our product candidates to be used in clinical trials and for
the majority of the services performed in connection with the preclinical and clinical development of our product candidates. Our external service costs for pimavanserin increased in the three and six months ended June 30, 2009 compared to the
three and six months ended June 30, 2008 primarily due to increased development costs associated with our Phase III program. Our internal research and development expenses decreased significantly in the three and six months ended June 30,
2009 compared to the three and six months ended June 30, 2008 primarily due to our strategic restructuring implemented in August 2008. To the extent that external expenses are not attributable to a specific project, they are included in other
external costs. The following table summarizes our research and development expenses for the three and six months ended June 30, 2009 and 2008 (in thousands):



|                               |             |                            |             |                          |      |        |      |   |        |  |   |       
|------------------------------ | ----------- | -------------------------- | ----------- | ------------------------ | ---- | ------ | ---- | - | ------ |  | - | ------
|                               |             | Three Months EndedJune 30, |             | Six Months EndedJune 30,
|                               | 2009        |                            | 2008        |                          | 2009 |        | 2008
|                               | (unaudited) |                            | (unaudited)
|External costs:                |             |                            |             |                          |      |        |      |   |        |  |   |       
|Pimavanserin                   |             | $                          | 8,029       |                          | $    | 6,668  |      | $ | 16,891 |  | $ | 12,744
|ACP-1041                       |             |                            | 13          |                          |      | 1,253  |      |   | 39     |  |   | 2,633 
|ACP-106, AM-831 and other      |             |                            | 348         |                          |      | 1,000  |      |   | 592    |  |   | 1,374 
|                               |             |                            |             |                          |      |        |      |   |        |  |   |       
|Subtotal                       |             |                            | 8,390       |                          |      | 8,921  |      |   | 17,522 |  |   | 16,751
|Internal costs                 |             |                            | 3,306       |                          |      | 6,735  |      |   | 6,507  |  |   | 13,661
|Stock-based compensation       |             |                            | 283         |                          |      | 380    |      |   | 504    |  |   | 795   
|                               |             |                            |             |                          |      |        |      |   |        |  |   |       
|Total research and development |             | $                          | 11,979      |                          | $    | 16,036 |      | $ | 24,533 |  | $ | 31,207
|                               |             |                            |             |                          |      |        |      |   |        |  |   |       



|1. | ACP-104 was a product candidate that we were previously developing. We currently do not anticipate conducting further studies with ACP-104.
|-- | -------------------------------------------------------------------------------------------------------------------------------------------

At this time, due to the risks inherent in the clinical trial process and given the stage of development of our programs, we are unable to estimate with
any certainty the costs we will incur for the continued development of our product candidates for potential commercialization. Due to these same factors, we are unable to determine the anticipated completion dates for our current research and
development programs. Clinical development timelines, probability of success, and development costs vary widely. While our current focus is primarily on advancing the clinical development of pimavanserin, we anticipate that we will make
determinations as to which programs to pursue and how much funding to direct to each program on an ongoing basis in response to the scientific and clinical success of each product candidate, as well as an ongoing assessment of each product
candidates commercial potential and



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our financial position. We cannot forecast with any degree of certainty when and to what extent we will receive cash inflows from the development or
commercialization of pimavanserin pursuant to our agreement with Biovail. We also cannot forecast with any degree of certainty which product candidates will be subject to future collaborative or licensing arrangements, when such arrangements will be
secured, if at all, and to what degree such arrangements would affect our development plans and capital requirements.

We expect our
external research and development expenses to continue to be substantial as we pursue the development of pimavanserin and our other product candidates. The lengthy process of completing clinical trials and seeking regulatory approval for our product
candidates requires the expenditure of substantial resources. Any failure by us or delay in completing clinical trials, or in obtaining regulatory approvals could cause our research and development expenses to increase and, in turn, have a material
adverse effect on our results of operations.

General and Administrative Expenses

Our general and administrative expenses consist primarily of salaries and other costs for employees serving in executive, finance, business development,
and business operations functions, as well as professional fees associated with legal and accounting services, and costs associated with patents and patent applications for our intellectual property.

Critical Accounting Policies and Estimates

Our
discussion and analysis of our financial condition and results of operations is based on our consolidated financial statements. We have identified the accounting policies that we believe require application of managements most subjective
judgments, often requiring the need to make estimates about the effect of matters that are inherently uncertain and may change in subsequent periods. Our actual results may differ substantially from these estimates under different assumptions or
conditions.

Revenue Recognition

We recognize revenues in accordance with Securities and Exchange Commission Staff Accounting Bulletin No. 104, Revenue Recognition,and Emerging Issues Task Force Issue No. 00-21 (EITF 00-21), Revenue Arrangements
with Multiple Deliverables.Our revenues are primarily related to our collaboration agreements, which may provide for various types of payments to us, including upfront payments, funding of research and development, milestone payments,
and licensing fees. Our collaboration agreements also include potential payments for product royalties and commercial co-promotion, however, we have not received revenue from these two sources to date.

We consider a variety of factors in determining the appropriate method of accounting under our collaboration agreements, including whether the various
elements can be separated and accounted for individually as separate units of accounting in accordance with EITF 00-21. Where there are multiple deliverables identified within a collaboration agreement that are combined into a single unit of
accounting, revenues are deferred and recognized over the expected period of performance. The specific methodology for the recognition of the revenue is determined on a case-by-case basis according to the facts and circumstances applicable to each
agreement.

Upfront, non-refundable payments that do not have stand-alone value are recorded as deferred revenue once received and
recognized as revenues over the expected period of performance. Revenues from non-refundable license fees are recognized upon receipt of the payment if the license has stand-alone value, we do not have ongoing involvement or obligations, and the
fair value of any undelivered items can be determined. Non-refundable payments for research funding are generally recognized as revenues over the period as the related research activities are performed. Payments for reimbursement of external
development costs are generally recognized as revenues using a contingency-adjusted performance model over the expected period of performance.

We assess milestone payments on an individual basis and recognize revenues from non-refundable milestone payments when the earnings process is complete and the payment is reasonably assured. Non-refundable milestone payments related to
arrangements under which we have continuing performance obligations are recognized as revenue upon achievement of the associated milestone, provided that (i) the milestone event is substantive and its achievability was not reasonably assured at
the inception of the agreement and (ii) the amount of the milestone payment is reasonable in relation to the effort expended or the risk associated with the milestone event. Where separate milestone payments do not meet these criteria, we
typically recognize revenue using a contingency-adjusted performance model over the remaining period of performance.



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Accrued Expenses

We are required to estimate accrued expenses as part of our process of preparing financial statements. Examples of areas in which subjective judgments may be required include costs associated with services provided by
contract organizations for preclinical development, manufacturing of clinical materials, and clinical trials. We accrue for costs incurred as the services are being provided by monitoring the status of the trials or services provided, and the
invoices received from our external service providers. In the case of clinical trials, a portion of the cost normally relates to the projected cost to treat a patient in our trials and we recognize this cost over the estimated term of the study
based on the number of patients enrolled in the trial on an ongoing basis, beginning with patient enrollment. As actual costs become known to us, we adjust our accruals. To date, our estimates have not differed significantly from the actual costs
incurred. However, we have expanded the level of our clinical trials and related services. As a result, we anticipate that our estimated accruals for clinical services will be more material to our operations in future periods. Subsequent changes in
estimates may result in a material change in our accruals, which could also materially affect our balance sheet and results of operations.

Stock-based Compensation

Effective January 1, 2006, we adopted the fair value recognition provisions of
Statement of Financial Accounting Standards (SFAS, No. 123) (revised 2004), Share-Based Payment (SFAS No. 123(R)), to account for employee stock options and stock issued under the employee stock purchase
plan.

The value of each employee stock option and each employee stock purchase right granted is estimated on the grant date under the fair
value method using the Black-Scholes option pricing model. For options granted prior to January 1, 2006, we amortize the fair value on an accelerated basis. For options granted after January 1, 2006, we amortize the fair value on a
straight-line basis. All option expense is amortized over the requisite service period of the awards, which is generally the vesting period. As of June 30, 2009, total unrecognized compensation cost related to stock options and purchase rights
was approximately $4.1 million, and the weighted average period over which this cost is expected to be recognized is 2.5 years.

Stock-based awards issued to non-employees other than directors are accounted for using a fair value method and are re-measured to fair value at each period end until the earlier of the date that performance by the non-employee is complete
or a performance commitment has been obtained. The fair value of each award is estimated using the Black-Scholes option pricing model.

Results of
Operations

Fluctuations in Operating Results

Our results of operations have fluctuated significantly from period to period in the past and are likely to continue to do so in the future. We anticipate that our quarterly and annual results of operations will be
impacted for the foreseeable future by several factors, including the timing and amount of payments received pursuant to our current and potential future collaborations, and the progress and timing of expenditures related to our discovery and
development efforts. Due to these fluctuations, we believe that the period-to-period comparisons of our operating results are not a good indication of our future performance.

Comparison of the Three Months Ended June 30, 2009 and 2008

Revenues

Revenues totaled $1.8 million for the three months ended June 30, 2009 compared to $177,000 for the three months ended June 30, 2008. The
increase in revenues was primarily due to $1.4 million in initial revenues recognized under our collaboration with Biovail, for the period from the effective date of the agreement on May 1, 2009 through June 30, 2009. Revenues from our
collaborations with Allergan totaled $265,000 for the three months ended June 30, 2009 compared to $177,000 for the three months ended June 30, 2008. Revenues from our collaboration with Meija Seika and smaller scale research agreements
with other parties totaled $147,000 for the three months ended June 30, 2009.

Research and Development Expenses

Research and development expenses decreased to $12.0 million for the three months ended June 30, 2009, including $283,000 in stock-based
compensation, compared to $16.0 million for the three months ended June 30, 2008, including $380,000 in stock-based compensation. The decrease in research and development expenses was primarily due to $3.5 million in decreased costs associated
with our internal research and development organization and $531,000 in lower external service costs. The decrease in internal research and development costs was primarily attributable to $2.3 million in decreased salaries and related personnel
costs, and decreases in laboratory supply, equipment and other costs resulting from our strategic restructuring. External service costs totaled $8.4 million, or 70 percent of our research and development expenses for the three months ended
June 30, 2009, compared to $8.9 million, or 56 percent of our research and development expenses, for the comparable period in 2008. Increased development costs for pimavanserin during the three months ended June 30, 2009 were offset by
lower costs incurred for ACP-104 and other programs.



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General and Administrative Expenses

General and administrative expenses totaled $2.7 million for the three months ended June 30, 2009, including $333,000 in stock-based compensation, compared to $3.2 million for the three months ended June 30,
2008, including $431,000 in stock-based compensation. The decrease in general and administrative expenses was primarily due to $247,000 in decreased salaries and related personnel costs, and decreases in other administrative costs, partially offset
by increased external service costs.

Interest Income

Interest income decreased to $117,000 for the three months ended June 30, 2009 from $802,000 for the three months ended June 30, 2008. The decrease in interest income during the three months ended
June 30, 2009 was due to decreased yields on our investment security portfolio and lower average levels of cash and investment securities.

Comparison of the Six Months Ended June 30, 2009 and 2008

Revenues

Revenues totaled $2.2 million for the six months ended June 30, 2009 compared to $983,000 for the six months ended June 30, 2008. The increase
in revenues was primarily due to $1.4 million in initial revenues recognized under our collaboration with Biovail, which commenced in May 2009, partially offset by lower revenues from our agreements with other parties. Revenues from our
collaboration with Meija Seika and smaller scale research agreements with other parties totaled $252,000 for the six months ended June 30, 2009, compared to $388,000 from smaller scale research agreements for the six months ended June 30,
2008. In addition, revenues from our agreement with Sepracor, which ended in January 2008, totaled $91,000 for the six months ended June 30, 2008. Revenues from our agreements with Allergan totaled $534,000 for the six months ended
June 30, 2009 compared to $504,000 for the six months ended June 30, 2008.

Research and Development Expenses

Research and development expenses decreased to $24.5 million for the six months ended June 30, 2009, including $504,000 in stock-based compensation,
from $31.2 million for the six months ended June 30, 2008, including $795,000 in stock-based compensation. The decrease in research and development expenses was primarily due to $7.4 million in decreased costs associated with our internal
research and development organization, partially offset by $771,000 in increased external service costs. The decrease in internal research and development costs was primarily attributable to $4.8 million in decreased salaries and related personnel
costs, $1.2 million in decreased laboratory supply costs, and decreases in equipment and other costs resulting from our strategic restructuring. External service costs totaled $17.5 million, or 71 percent of our research and development expenses,
for the six months ended June 30, 2009, compared to $16.8 million, or 54 percent of our research and development expenses, for the comparable period in 2008. The increase in external expenses was largely attributable to increased development
costs for pimavanserin, partially offset by lower costs incurred for ACP-104 and other programs.

General and Administrative Expenses

General and administrative expenses totaled $5.6 million for the six months ended June 30, 2009, including $687,000 in stock-based compensation,
compared to $6.5 million for the six months ended June 30, 2008, including $852,000 in stock-based compensation. The decrease in general and administrative expenses was primarily due to $773,000 in decreased salaries and related personnel
costs, and decreases in other expenses, partially offset by $489,000 in increased external service costs.

Interest Income

Interest income decreased to $308,000 for the six months ended June 30, 2009 from $2.1 million for the six months ended June 30, 2008. The
decrease in interest income during the six months ended June 30, 2009 was due to decreased yields on our investment security portfolio and lower average levels of cash and investment securities.



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Liquidity and Capital Resources

Since inception, we have funded our operations primarily through sales of our equity securities, payments received under our collaboration agreements, debt financings, and interest income. As of June 30, 2009, we
had received $324.9 million in net proceeds from sales of our equity securities, including $6.9 million in debt we had retired through the issuance of our common stock, $92.5 million in payments from collaboration agreements, $22.4 million in debt
financing, and $21.9 million in interest income.

At June 30, 2009, we had approximately $66.2 million in cash, cash equivalents and
investment securities compared to $60.1 million at December 31, 2008.

We have consumed substantial amounts of capital since our
inception. In August 2008, we implemented a strategic restructuring, which has reduced our internal operating expenses significantly. As a result, we expect that the cash used in our operating activities will be lower in 2009 compared to 2008. We
anticipate that our cash, cash equivalents and investment securities will be greater than $40 million at December 31, 2009, and that our existing cash resources and payments from our collaborations will be sufficient to fund our operations at
least into the first half of 2011.

We will require significant additional financing in the future to fund our operations. Our
future capital requirements will depend on, and could increase significantly as a result of, many factors, including:



| |  |  | progress in, and the costs of, our clinical trials, preclinical studies and other research and development programs;
| | - |  | --------------------------------------------------------------------------------------------------------------------



| |  |  | the scope, prioritization and number of research and development programs;
| | - |  | --------------------------------------------------------------------------



| |  |  | the ability of our collaborators and us to reach the milestones, and other events or developments, under our collaboration agreements;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the costs involved in filing, prosecuting, enforcing and defending patent claims and other intellectual property rights;
| | - |  | ------------------------------------------------------------------------------------------------------------------------



| |  |  | the costs of securing manufacturing arrangements for clinical or commercial production of product candidates; and
| | - |  | -----------------------------------------------------------------------------------------------------------------



| |  |  | the costs of establishing, or contracting for, sales and marketing capabilities if we obtain regulatory clearances to market our product candidates.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------

Until we can generate significant continuing revenues, we expect to satisfy our future cash needs through strategic
collaborations, private or public sales of our securities, debt financings, or by licensing all or a portion of our product candidates or technology. In August 2008, we entered into a Committed Equity Financing Facility, or CEFF, which provides us
with access, at our discretion, to up to $60 million of capital during a three-year period through the sale of newly-issued shares of our common stock. We may access capital under the CEFF in tranches of up to a maximum of between 2.0 and 3.5
percent of our market capitalization at the time of the draw down of each tranche, subject to certain conditions, including a minimum share price threshold of $1.50. The funds that can be raised under the CEFF, if available, will depend on the
then-current price of our common stock and the number of shares actually sold, which may not exceed an aggregate of approximately 7 million shares. To date, we have not raised any funds pursuant to the CEFF.

We cannot be certain that funding will be available to us on acceptable terms, or at all. Turmoil in the financial markets has adversely affected the
market capitalizations of many biotechnology companies and generally made equity and debt financing more difficult to obtain. This, coupled with other factors, may limit access to additional financing over the near-term future. In particular, given
the current market conditions, any unfavorable outcome over the next year in one or more of the studies that we are currently conducting in our Phase III program with pimavanserin, including the first Phase III pivotal trial, could have a material
adverse effect on us and our ability to raise additional capital.

If we cannot raise adequate additional capital in the future under the
CEFF or from other sources, we will be required to delay, further reduce the scope of, or eliminate one or more of our research or development programs or our commercialization efforts. We also may be required to relinquish greater or all rights to
product candidates at an earlier stage of development or on less favorable terms than we would otherwise choose. In addition, should we be required to further reduce the scope of our discovery activities, this may lead to an impairment of our
equipment and additional charges, which could materially affect our balance sheet and results of operations.

We have invested a
substantial portion of our available cash in a money market fund wholly-backed by U.S. Treasury collateral, in U.S. Treasury notes and in investment securities consisting of high quality, marketable debt instruments of corporations, financial
institutions, and government sponsored enterprises. We have adopted an investment policy and established guidelines relating to credit quality, diversification and maturities of our investments to preserve principal and maintain liquidity. All
investment securities



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have a credit rating of at least AA or A1+/P1 as determined by Moodys Investors Service and/or Standard & Poors. We do not have any
direct investments in auction-rate securities or securities that are collateralized by assets that include mortgages or subprime debt. Our investment portfolio has not been adversely impacted by the disruption in the credit markets. However, if
there is continued and expanded disruption in the credit markets, there can be no assurance that our investment portfolio will not be adversely affected in the future.

Net cash provided by operating activities increased to $6.7 million for the six months ended June 30, 2009 compared to net cash used in operating activities of $36.8 million for the six months ended June 30,
2008. This increase was primarily due to a decrease in our net loss and changes in operating assets and liabilities, including an increase in deferred revenue of $31.0 million and an aggregate increase of $1.4 million in accounts payable and accrued
expenses during the six months ended June 30, 2009. The increase in deferred revenue was primarily attributable to the upfront payment received from our collaboration with Biovail and initial licensing fees received from our collaboration with
Meiji Seika, offset by initial revenues recognized pursuant to these agreements. There was an aggregate decrease in accounts payable and accrued expenses of $4.9 million during the six months ended June 30, 2008 largely reflecting payments made
for external service costs related to our clinical trials.

Net cash used in investing activities totaled $9.6 million for the six months
ended June 30, 2009 compared to net cash provided by investing activities of $40.0 million for the six months ended June 30, 2008, and has fluctuated significantly from period to period primarily due to the timing of purchases and
maturities of investment securities. During the six months ended June 30, 2009, purchases of investment securities exceeded maturities by an aggregate of $9.6 million. During the comparable period of 2008, maturities of investment securities
exceeded purchases by an aggregate of $40.2 million.

We have entered into equipment financing agreements from time to time, which we have
utilized to fund the majority of our property and equipment purchases. The agreements contain fixed interest rates ranging from 9.34 to 10.41 percent per annum. At June 30, 2009, we had $788,000 in outstanding borrowings under these agreements,
which are secured by the related equipment.

The following table summarizes our contractual obligations, including interest, at
June 30, 2009 (in thousands):



|                 |  |       |        |                 |   |           |  |           |       |  |   |      
|---------------- |  | ----- | ------ | --------------- | - | --------- |  | --------- | ----- |  | - | -----
|                 |  | Total |        | Less than1 Year |   | 1-3 Years |  | 4-5 Years
|Operating leases |  | $     | 10,787 |                 | $ | 2,268     |  | $         | 5,798 |  | $ | 2,721
|Long-term debt   |  |       | 856    |                 |   | 613       |  |           | 243   |  |   |     
|                 |  |       |        |                 |   |           |  |           |       |  |   |      
|Total            |  | $     | 11,643 |                 | $ | 2,881     |  | $         | 6,041 |  | $ | 2,721
|                 |  |       |        |                 |   |           |  |           |       |  |   |      

We also have entered into agreements with contract research organizations and other external
service providers for services in connection with the development of our product candidates. We were contractually obligated for up to approximately $19.0 million of future services under these agreements as of June 30, 2009, the majority of
which are expected to be provided by the end of December 2010. The nature of the work being conducted under our agreements with contract research organizations is such that, in most cases, the services may be stopped with short notice. In such
event, we would not be liable for the full amount of the contract. Our actual contractual obligations may vary depending upon several factors, including the progress and results of the underlying studies.

In addition, we have entered into an agreement pursuant to which we licensed certain intellectual property rights that complement our patent portfolio.
If certain conditions are met, we would be required to make future payments, including milestone payments, sublicensing fees and royalties. The amount of potential future milestone payments is $10.5 million in the aggregate, which amount would be
offset by any sublicensing fees we may pay under the agreement. Because these milestone payments would only be payable upon the achievement of specified regulatory events and it is uncertain when, or if, such events will occur, we cannot forecast
with any degree of certainty when, or if, we will be required to make those payments under the agreement. Accordingly, none of these amounts are included in the above table.



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Off-Balance Sheet Arrangements

To date, we have not had any relationships with unconsolidated entities or financial partnerships, such as entities referred to as structured finance or special purpose entities, which are established for the purpose
of facilitating off-balance sheet arrangements or other contractually narrow or limited purposes. As such, we are not materially exposed to any financing, liquidity, market or credit risk that could arise if we had engaged in these relationships.

Recent Accounting Pronouncements

See
Item 1 of Part I, Notes to Condensed Consolidated Financial Statements  Note 10  Recent Accounting Pronouncements.



|ITEM 3. | QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK
|------- | ----------------------------------------------------------

Interest Rate Risk

We invest our excess cash in investment-grade, interest-bearing
securities. The primary objective of our investment activities is to preserve principal and liquidity. To achieve this objective, we invest in a money market fund, in U.S. Treasury notes and in high quality marketable debt instruments of
corporations, financial institutions, and government sponsored enterprises with contractual maturity dates of generally less than two years. All investment securities have a credit rating of at least AA or A1+/P1 as determined by Moodys
Investors Service and/or Standard & Poors. We do not have any direct investments in auction-rate securities or securities that are collateralized by assets that include mortgages or subprime debt. If a 10 percent change in interest
rates were to have occurred on June 30, 2009, this change would not have had a material effect on the fair value of our investment portfolio as of that date.

Foreign Currency Risk

We have wholly owned subsidiaries in Sweden and Denmark, which expose us to foreign exchange
risk. The functional currency of our subsidiary in Sweden is the Swedish kroner and the functional currency of our subsidiary in Denmark is the Danish kroner. Accordingly, all assets and liabilities of our subsidiaries are translated to U.S. dollars
based on the applicable exchange rate on the balance sheet date. Expense components are translated to U.S. dollars at weighted average exchange rates in effect during the period. Gains and losses resulting from foreign currency translation are
included as a component of our stockholders equity. Other foreign currency transaction gains and losses are included in our results of operations and, to date, have not been significant. We have not hedged exposures denominated in foreign
currencies and we do not have any derivative financial instruments.



|ITEM 4. | CONTROLS AND PROCEDURES
|------- | -----------------------

We maintain disclosure controls and procedures that are designed to ensure that information required to be disclosed in our periodic and current reports that we file with the SEC is recorded, processed, summarized and reported within the
time periods specified in the SECs rules and forms, and that such information is accumulated and communicated to our management, including our Chief Executive Officer and Chief Financial Officer, as appropriate, to allow timely decisions
regarding required disclosure. In designing and evaluating the disclosure controls and procedures, management recognized that any controls and procedures, no matter how well designed and operated, can provide only reasonable and not absolute
assurance of achieving the desired control objectives. In reaching a reasonable level of assurance, management necessarily was required to apply its judgment in evaluating the cost-benefit relationship of possible controls and procedures. In
addition, the design of any system of controls also is based in part upon certain assumptions about the likelihood of future events, and there can be no assurance that any design will succeed in achieving its stated goals under all potential future
conditions; over time, control may become inadequate because of changes in conditions, or the degree of compliance with policies or procedures may deteriorate. Because of the inherent limitations in a cost-effective control system, misstatements due
to error or fraud may occur and not be detected.

As of June 30, 2009, we carried out an evaluation, under the supervision and with
the participation of our management, including our Chief Executive Officer and Chief Financial Officer, of the effectiveness of our disclosure controls and procedures, as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of
1934, as amended. Based on this evaluation, our Chief Executive Officer and Chief Financial Officer concluded that our disclosure controls and procedures were effective as of June 30, 2009.

An evaluation was also performed under the supervision and with the participation of our management, including our Chief Executive Officer and our Chief
Financial Officer, of any change in our internal control over financial reporting that occurred during our last fiscal quarter and that has materially affected, or is reasonably likely to materially affect, our internal control over financial
reporting. That evaluation did not identify any change in our internal control over financial reporting that occurred during our latest fiscal quarter that has materially affected, or is reasonably likely to materially affect, our internal control
over financial reporting.



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PART II. OTHER INFORMATION



|ITEM 1A. | RISK FACTORS
|-------- | ------------

You should consider carefully the following information about the risks described below, together with the other information contained in this Quarterly Report and in our other public filings in evaluating our business. The risk factors
set forth below that are marked with an asterisk (*) contain changes to the similarly titled risk factor included in Item 1A to our Annual Report. If any of the following risks actually occurs, our business, financial condition, results of
operations and future growth prospects would likely be materially and adversely affected. In these circumstances, the market price of our common stock would likely decline.

Risks Related to Our Business

We expect our net losses to continue for at least several years and are unable
to predict the extent of future losses or when we will become profitable, if ever.*

We have experienced significant net losses
since our inception. As of June 30, 2009, we had an accumulated deficit of approximately $321.8 million. We expect our annual net losses to continue over the next several years as we advance our programs and incur significant clinical
development costs.

We have not received, and do not expect to receive for at least the next several years, any revenues from the
commercialization of our product candidates. Substantially all of our revenues for the three and six months ended June 30, 2009 were from our collaborations with Biovail and Allergan as well as our agreements with other parties. We anticipate
that collaborations, which provide us with research funding and potential milestone payments and royalties, will continue to be our primary source of revenues for the next several years. We cannot be certain that the milestones required to trigger
payments under our existing collaborations will be reached or that we will secure additional collaboration agreements. To obtain revenues from our product candidates, we must succeed, either alone or with others, in developing, obtaining regulatory
approval for, and manufacturing and marketing drugs with significant market potential. We may never succeed in these activities, and may never generate revenues that are significant enough to achieve profitability.

We depend on collaborations with third parties to develop and commercialize selected product candidates and to provide substantially all of our revenues.*

A key aspect of our strategy is to selectively enter into collaborations with third parties. We currently rely, and will continue to rely,
on our collaborators for financial resources and for development, regulatory, and commercialization expertise for selected product candidates. During the three months ended June 30, 2009, we received a $30 million upfront payment from Biovail
and $2 million in licensing fees from Meiji Seika, pursuant to our respective collaborations with those parties. The ongoing research term of our agreements with Allergan will end in March 2010 and, other than research funding under our 2003
collaboration with Allergan and $1 million in licensing fees to be paid under the agreement with Meiji Seika, additional payments from our agreements with Biovail, Allergan, and Meiji Seika are dependent on successful advancement of our applicable
product candidates. There is no guarantee that revenues from our collaborations will continue at current or past levels. Given the current economic environment, it is possible that our existing collaborators may elect to reduce their external
spending.

Our collaborators may fail to develop or effectively commercialize products using our product candidates or technologies because
they:



| |  |  | do not have sufficient resources or decide not to devote the necessary resources due to internal constraints such as limited cash or human resources or a change in
strategic focus;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | decide to pursue a competitive product developed outside of the collaboration; or
| | - |  | ---------------------------------------------------------------------------------



| |  |  | cannot obtain the necessary regulatory approvals.
| | - |  | -------------------------------------------------

Each of Biovail, Meiji Seika and Allergan can terminate our existing collaborations under specific circumstances, including in some cases the right to terminate without cause upon prior notice. We may not be able to
renew our existing collaborations on acceptable terms, if at all. We also face competition in our search for new collaborators. Given the current economic environment, it is possible that competition for new collaborators may increase.



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Our most advanced product candidates are in clinical trials, which are long, expensive and unpredictable, and there
is a high risk of failure.*

Preclinical testing and clinical trials are long, expensive and unpredictable processes that can be
subject to delays. It may take several years to complete the preclinical testing and clinical development necessary to commercialize a drug, and delays or failure can occur at any stage. Interim results of clinical trials do not necessarily predict
final results, and success in preclinical testing and early clinical trials does not ensure that later clinical trials will be successful. A number of companies in the pharmaceutical and biotechnology industries have suffered significant setbacks in
advanced clinical trials even after promising results in earlier trials.

Our drug development programs are at various stages of
development and the historical rate of failures for product candidates is extremely high. In fact, we had an unsuccessful Phase II trial in 2008 with our product candidate, ACP-104. In our most advanced program, we are in Phase III development with
pimavanserin for the treatment of Parkinsons disease psychosis. Our Phase III program encompasses a number of studies, including two Phase III pivotal trials, an open-label safety extension trial and a range of supporting studies, including
carcinogenicity studies, a QTc study, and drug-drug interaction studies. We anticipate completing certain of the studies in this program, including the first Phase III pivotal trial, during 2009. An unfavorable outcome in one or more of the studies
in this program could be a major set-back for the program, our collaboration with Biovail and for our company, generally. In particular, given the current conditions in the financial markets, an unfavorable outcome in one or more of these studies
may require us to delay, reduce the scope of, or eliminate this program and could have a material adverse effect on our company and the value of our common stock. We also have chronic pain and glaucoma clinical programs in collaboration with
Allergan, which are in Phase II and Phase I development, respectively.

In connection with clinical trials, we face risks that:



| |  |  | a product candidate may not prove to be efficacious;
| | - |  | ----------------------------------------------------



| |  |  | patients may die or suffer other adverse effects for reasons that may or may not be related to the product candidate being tested;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------



| |  |  | the results may not confirm the positive results of earlier trials; and
| | - |  | -----------------------------------------------------------------------



| |  |  | the results may not meet the level of statistical significance required by the U.S. Food and Drug Administration, or FDA, or other regulatory agencies.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------

If we do not successfully complete preclinical and clinical development, we will be unable to market and sell products
derived from our product candidates and to generate product revenues. Even if we do successfully complete clinical trials, those results are not necessarily predictive of results of additional trials that may be needed before a new drug application,
or NDA, may be submitted to the FDA. Of the large number of drugs in development, only a small percentage result in the submission of an NDA to the FDA and even fewer are approved for commercialization.

Delays, suspensions and terminations in our clinical trials could result in increased costs to us and delay our ability to generate product revenues.

The commencement of clinical trials can be delayed for a variety of reasons, including delays in:



| |  |  | demonstrating sufficient safety and efficacy to obtain regulatory approval to commence a clinical trial;
| | - |  | --------------------------------------------------------------------------------------------------------



| |  |  | reaching agreement on acceptable terms with prospective contract research organizations and clinical trial sites;
| | - |  | -----------------------------------------------------------------------------------------------------------------



| |  |  | manufacturing sufficient quantities of a product candidate;
| | - |  | -----------------------------------------------------------



| |  |  | obtaining approval of an Investigational New Drug Application, or IND, from the FDA;
| | - |  | ------------------------------------------------------------------------------------



| |  |  | obtaining institutional review board approval to conduct a clinical trial at a prospective clinical trial site; and
| | - |  | -------------------------------------------------------------------------------------------------------------------



| |  |  | patient enrollment, which is a function of many factors, including the size of the patient population, the nature of the protocol, the proximity of patients to
clinical trial sites, the availability of effective treatments for the relevant disease and the eligibility criteria for the clinical trial.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Once a clinical trial has begun, it may be delayed, suspended or terminated due to a number of factors, including:



| |  |  | ongoing discussions with regulatory authorities regarding the scope or design of our clinical trials or requests by them for supplemental information with respect
to our clinical trial results;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | failure to conduct clinical trials in accordance with regulatory requirements;
| | - |  | ------------------------------------------------------------------------------



| |  |  | lower than anticipated retention rate of patients in clinical trials;
| | - |  | ---------------------------------------------------------------------



| |  |  | serious adverse events or side effects experienced by participants; and
| | - |  | -----------------------------------------------------------------------



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| |  |  | insufficient supply or deficient quality of product candidates or other materials necessary for the conduct of our clinical trials.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------

Many of these factors may also ultimately lead to denial of regulatory approval of a current or potential product candidate. If we experience delays,
suspensions or terminations in a clinical trial, the commercial prospects for the related product candidate will be harmed, and our ability to generate product revenues will be delayed.

If we fail to obtain the capital necessary to fund our operations, we will be unable to successfully develop products.*

We have consumed substantial amounts of capital since our inception. Our cash and investment securities totaled approximately $66.2 million at June 30, 2009. We believe our existing cash resources and anticipated
payments from our collaborations will be sufficient to fund our cash requirements at least into the first half of 2011. However, we will require significant additional financing in the future to continue to fund our operations. Our future capital
requirements will depend on, and could increase significantly as a result of, many factors including:



| |  |  | progress in, and the costs of, our preclinical studies and clinical trials and other research and development programs;
| | - |  | -----------------------------------------------------------------------------------------------------------------------



| |  |  | the scope, prioritization and number of our research and development programs;
| | - |  | ------------------------------------------------------------------------------



| |  |  | the ability of our collaborators and us to reach the milestones, and other events or developments, triggering payments under our collaboration agreements or to
otherwise make payments under these agreements;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the costs involved in filing, prosecuting, enforcing and defending patent claims and other intellectual property rights;
| | - |  | ------------------------------------------------------------------------------------------------------------------------



| |  |  | the costs of securing manufacturing arrangements for clinical or commercial production;
| | - |  | ---------------------------------------------------------------------------------------



| |  |  | the costs of establishing or contracting for sales and marketing capabilities if we obtain regulatory clearances to market our product candidates; and
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the costs associated with litigation.
| | - |  | -------------------------------------

Until we can generate significant continuing revenues, we expect to satisfy our future cash needs through our existing cash, cash equivalents and investment securities, strategic collaborations, private or public sales of our securities,
debt financings, or by licensing all or a portion of our product candidates or technology. The recent deterioration in the financial markets has adversely affected the market capitalizations of many biotechnology companies, including us, and
generally made equity and debt financing more difficult to obtain. This, coupled with other factors, may limit our access to additional financing over the near-term future. This could have a material adverse effect on our ability to access
sufficient funding, including pursuant to our CEFF or from other sources. Specifically, we will not be able to raise money under the CEFF if the average price of our common stock is below the minimum share price of $1.50. We cannot be certain that
additional funding will be available to us on acceptable terms, if at all. If funds are not available, we may be required to delay, reduce the scope of, or eliminate one or more of our research or development programs or our commercialization
efforts. Additional funding, if obtained, may significantly dilute existing stockholders, including any funds that may be raised under the CEFF.

Our
Committed Equity Financing Facility, or CEFF, may not be available to us if we elect to make a draw down, may require us to make additional blackout or other payments to Kingsbridge and may result in dilution to our stockholders.

Pursuant to the CEFF, Kingsbridge committed to purchase up to the lesser of $60 million or up to approximately 7 million
shares of our common stock over a three-year period, if we elect to use this facility. Kingsbridge will not be obligated to purchase shares under the CEFF unless specified conditions are met, which include a minimum price of $1.50 for our common
stock, the effectiveness of a registration statement registering for resale the shares of common stock to be issued in connection with the CEFF, and customary other conditions, such as accuracy of representations and warranties and compliance with
applicable laws. Kingsbridge is permitted to terminate the CEFF under certain circumstances. If we are unable to access funds through the CEFF or Kingsbridge terminates the CEFF, we may be unable to access capital on favorable terms or at all.

In connection with the CEFF, we filed a registration statement with the SEC to register the resale of shares of our common stock that may
be issued pursuant to the CEFF or upon exercise of the warrant. This registration statement was declared effective by the SEC on September 23, 2008. We are entitled, in certain circumstances, to deliver a blackout notice to
Kingsbridge to suspend the use of the prospectus, which is a part of such registration statement, and prohibit Kingsbridge from selling shares under that prospectus for a certain period of time. If we deliver a blackout notice in the 15 trading days
following the settlement of a draw down, or if the registration statement covering the resale of the shares of common stock to be issued in connection with the CEFF is not effective in circumstances not permitted by our registration rights agreement
with Kingsbridge, then we must make a payment to Kingsbridge, or issue Kingsbridge additional shares in lieu of this payment, calculated on the basis of a specified number of shares



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held by Kingsbridge immediately prior to the blackout period and the change in the market price of our common stock during the period in which the use of the
resale registration statement is suspended. If the trading price of our common stock declines during a suspension of the resale registration statement, the blackout or other payment could be significant.

If we sell shares to Kingsbridge under the CEFF, or issue shares in lieu of any blackout payment, it will have a dilutive effect on the holdings of our
current stockholders, and may result in downward pressure on the price of our common stock. If we draw down amounts under the CEFF, we will issue shares to Kingsbridge at a discount of up to 12% from the volume weighted average price of our common
stock. If we draw down amounts under the CEFF when our share price is decreasing, we will need to issue more shares to raise the same amount than if our stock price was higher. Issuances in the face of a declining share price will have an even
greater dilutive effect than if our share price were stable or increasing and may further decrease our share price.

If conflicts arise with our
collaborators, they may act in their self interests, which may be adverse to our interests.*

Conflicts may arise in our
collaborations due to one or more of the following:



| |  |  | disputes or breaches with respect to payments that we believe are due under the applicable agreements, particularly in the current economic environment when
companies, including large established ones, may be seeking to reduce external payments;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | disputes on strategy as to what development or commercialization activities should be pursued under the applicable agreements;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------



| |  |  | disputes as to the responsibility for conducting development and commercialization activities pursuant to the applicable collaboration, including the payment of
costs related thereto;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | disagreements with respect to ownership of intellectual property rights;
| | - |  | ------------------------------------------------------------------------



| |  |  | unwillingness on the part of a collaborator to keep us informed regarding the progress of its development and commercialization activities, or to permit public
disclosure of these activities;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | delay of a collaborators development or commercialization efforts with respect to our product candidates; or
| | - |  | -------------------------------------------------------------------------------------------------------------



| |  |  | termination or non-renewal of the collaboration.
| | - |  | ------------------------------------------------

Conflicts arising with our collaborators could impair the progress of our product candidates, harm our reputation, result in a loss of revenues, reduce our cash position, and cause a decline in our stock price.

In addition, in our collaborations, we generally have agreed not to conduct independently, or with any third party, any research that is
directly competitive with the research conducted under the applicable program. Our collaborations may have the effect of limiting the areas of research that we may pursue, either alone or with others. Our collaborators, however, may develop, either
alone or with others, products in related fields that are competitive with the products or potential products that are the subject of these collaborations. Competing products, either developed by our collaborators or to which our collaborators have
rights, may result in the allocation of resources by our competitors to competing products and their withdrawal of support for our product candidates or may otherwise result in lower demand for our potential products.

We have collaborations with Allergan for the development of product candidates related to chronic pain and ophthalmic diseases, including glaucoma.
Allergan currently markets therapeutic products to treat glaucoma and is engaged in other research programs related to glaucoma and other ophthalmic products that are independent from our development program in this therapeutic area. Allergan is
also pursuing other research programs related to pain management that are independent from our collaboration in this therapeutic area.

Our
collaboration with Meiji Seika is initially focused on the advancement of precognitive drugs (PCAPs) as a treatment for schizophrenia and related disorders. While Meiji Seika has rights to the PCAPs in the Asian territory, we have the
right to pursue them, alone or with a partner, in the rest of the world. Under our collaboration for pimavanserin, Biovail has licensed the rights to Canada and the United States for the treatment of PDP, ADP and other neurological and psychiatric
conditions, which could include schizophrenia. We have retained the rights to pimavanserin for the rest of the world. It is possible that the product candidates being developed under these programs could compete with each other. In addition,
Biovails strategy is to pursue the commercialization of product candidates for central nervous system indications that are independent of our efforts to develop and commercialize pimavanserin.



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We rely on third parties to conduct our clinical trials and perform data collection and analysis, which may result
in costs and delays that prevent us from successfully commercializing product candidates.

Although we design and manage our current
preclinical studies and clinical trials, we currently do not have the ability to conduct clinical trials for our product candidates on our own. In addition to our collaborators, we rely on contract research organizations, medical institutions,
clinical investigators, and contract laboratories to perform data collection and analysis and other aspects of our clinical trials. In addition, we also rely on third parties to assist with our preclinical studies, including studies regarding
biological activity, safety, absorption, metabolism, and excretion of product candidates.

Our preclinical activities or clinical trials
may be delayed, suspended, or terminated if:



| |  |  | these third parties do not successfully carry out their contractual duties or fail to meet regulatory obligations or expected deadlines;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------



| |  |  | these third parties need to be replaced; or
| | - |  | -------------------------------------------



| |  |  | the quality or accuracy of the data obtained by these third parties is compromised due to their failure to adhere to our clinical protocols or regulatory
requirements or for other reasons.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Failure to perform by these third parties may increase our development costs, delay
our ability to obtain regulatory approval, and delay or prevent the commercialization of our product candidates. We currently use several contract research organizations to perform services for our preclinical studies and clinical trials. While we
believe that there are numerous alternative sources to provide these services, in the event that we seek such alternative sources, we may not be able to enter into replacement arrangements without delays or additional expenditures.

Even if we or our collaborators successfully complete the clinical trials of product candidates, the product candidates may fail for other reasons.

Even if we or our collaborators successfully complete the clinical trials of product candidates, the product candidates may fail
for other reasons, including the possibility that the product candidates will:



| |  |  | fail to receive the regulatory clearances required to market them as drugs;
| | - |  | ---------------------------------------------------------------------------



| |  |  | be subject to proprietary rights held by others requiring the negotiation of a license agreement prior to marketing;
| | - |  | --------------------------------------------------------------------------------------------------------------------



| |  |  | be difficult or expensive to manufacture on a commercial scale;
| | - |  | ---------------------------------------------------------------



| |  |  | have adverse side effects that make their use less desirable; or
| | - |  | ----------------------------------------------------------------



| |  |  | fail to compete with product candidates or other treatments commercialized by competitors.
| | - |  | ------------------------------------------------------------------------------------------

Our product candidates may not gain acceptance among physicians, patients, and the medical community, thereby limiting our potential to generate revenues.

Even if our product candidates are approved for commercial sale by the FDA or other regulatory authorities, the degree of market acceptance
of any approved product candidate by physicians, healthcare professionals and third-party payors, and our profitability and growth will depend on a number of factors, including:



| |  |  | the ability to provide acceptable evidence of safety and efficacy;
| | - |  | ------------------------------------------------------------------



| |  |  | relative convenience and ease of administration;
| | - |  | ------------------------------------------------



| |  |  | the prevalence and severity of any adverse side effects;
| | - |  | --------------------------------------------------------



| |  |  | availability of alternative treatments;
| | - |  | ---------------------------------------



| |  |  | pricing and cost effectiveness, which may be subject to regulatory control;
| | - |  | ---------------------------------------------------------------------------



| |  |  | effectiveness of our or our collaborators sales and marketing strategy; and
| | - |  | ----------------------------------------------------------------------------



| |  |  | our ability to obtain sufficient third-party insurance coverage or reimbursement.
| | - |  | ---------------------------------------------------------------------------------

If any product candidate that we discover and/or develop does not provide a treatment regimen that is as beneficial as the current standard of care or
otherwise does not provide patient benefit, that product will not achieve market acceptance and we will not generate sufficient revenues to achieve or maintain profitability.

If we are unable to attract, retain, and motivate key management and scientific staff, our drug development programs and our research and discovery efforts may be delayed and we may be unable to successfully
develop or commercialize our product candidates.

Our success depends on our ability to attract, retain, and motivate highly
qualified management and scientific personnel. In particular, our drug discovery and development programs depend on our ability to attract and retain highly skilled chemists, biologists, pharmacologists, and development personnel, especially in the
fields of central nervous system disorders, including



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neuropsychiatric and related disorders. In the future, we may need to hire additional personnel if we expand our research and development efforts from our
current levels. We face competition for experienced scientists, clinical operations personnel, and other technical personnel from numerous companies and academic and other research institutions. Competition for qualified personnel is particularly
intense in the San Diego, California area. If we are unable to attract and retain the necessary personnel, this will significantly impede the achievement of our research and development objectives and our ability to meet the demands of our
collaborators in a timely fashion.

All of our U.S. employees are at will employees, which means that any employee may quit at
any time and we may terminate any employee at any time. We do not carry key person insurance covering members of senior management.

We
do not know whether our drug discovery platform will lead to the discovery or development of commercially viable product candidates.

Our drug discovery platform uses new and unproven methods to identify and develop product candidates. We have never successfully completed clinical development of any of our product candidates, and there are no drugs on the market that have
been discovered using our drug discovery platform.

Much of our research focuses on small molecule drugs for the treatment of central
nervous system disorders. Due to our limited resources, we may have to forego potential opportunities with respect to discovering product candidates to treat diseases or conditions in other therapeutic areas. If we are not able to use our
technologies to discover and develop product candidates that can be commercialized, we may not achieve profitability. In the future, we may find it necessary to license the technology of others or acquire additional product candidates to augment the
results of our internal discovery activities. If we are unable to identify new product candidates using our drug discovery platform, we may be unable to establish or maintain a clinical development pipeline or generate product revenues.

We may not be able to continue or fully exploit our collaborations with outside scientific and clinical advisors, which could impair the progress of our
clinical trials and our research and development efforts.

We work with scientific and clinical advisors at academic and other
institutions who are experts in the field of central nervous system disorders. They assist us in our research and development efforts and advise us with respect to our clinical trials. These advisors are not our employees and may have other
commitments that would limit their future availability to us. Although our scientific and clinical advisors generally agree not to engage in competing work, if a conflict of interest arises between their work for us and their work for another
entity, we may lose their services, which may impair our reputation in the industry and delay the development or commercialization of our product candidates.

If we do not continue to realize the expected benefits from the restructuring that we announced in August 2008, our operating results and financial conditions would be negatively impacted.*

In August 2008, we implemented a strategic restructuring designed to focus our resources on our most advanced product candidates. If we are unable to
continue to realize the expected operational efficiencies from our restructuring, our operating results and financial condition would be adversely affected. We cannot guarantee that we will not have to undertake additional restructuring activities,
that any of our restructuring efforts will be successful, or that we will be able to continue to realize the cost savings and other anticipated benefits from our restructuring. Additionally, employees whose positions were eliminated in connection
with the restructuring may seek future employment with our competitors. Although each of our employees is required to sign a confidentiality agreement with us at the time of hire, we cannot guarantee that the confidential nature of our proprietary
information will be maintained in the course of such future employment.

We will need to transition our organization in connection with our
restructuring, and we may encounter difficulties managing this transition, which could adversely affect our results of operations.*

We will need to effectively manage our operations and facilities in order to advance our drug development programs, including those covered by our collaborations with Biovail and Meiji Seika, achieve milestones under our collaboration
agreements, facilitate additional collaborations, and pursue other development activities. Following our restructuring, it is possible that our infrastructure may be inadequate to support our future efforts and growth. To manage our transition, we
will be required to continue to improve our operational, financial and management controls, and reporting systems and procedures. In addition, we may have to develop internal sales, marketing, and distribution capabilities if we decide to market any
drug that we may successfully develop. We may not successfully manage the transition of our operations and, accordingly, may not achieve our research, development, and commercialization goals.



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We face financial and administrative challenges in coordinating the operations of our European activities with our
activities in California, which could have an adverse impact on our operations.*

Our principal executive offices are located in San
Diego and we also have a subsidiary, ACADIA Pharmaceuticals AB, located in Malmö, Sweden that employed a small percentage of our total personnel as of June 30, 2009. The additional administrative expense required to coordinate activities
in both Europe and California could divert management resources from other important endeavors and, in turn, delay our development and commercialization efforts. In addition, currency fluctuations involving our Swedish operations may cause foreign
currency gains and losses. These exchange-rate fluctuations could have a negative effect on our operations. We do not engage in currency hedging transactions.

We expect that our results of operations will fluctuate, which may make it difficult to predict our future performance from period to period.*

Our quarterly operating results have fluctuated in the past and are likely to do so in the future. Some of the factors that could cause our operating results to fluctuate from period to period include:



| |  |  | the status of development of pimavanserin and our other product candidates, including compounds being developed under our collaborations;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------



| |  |  | whether we generate revenues by achieving specified research, development or commercialization milestones under any agreements or otherwise receive potential
payments under these agreements;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | whether we are required to make payments due to achieving specified milestones under any licensing or similar agreements or otherwise make potential payments under
these agreements;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the incurrence of preclinical or clinical expenses that could fluctuate significantly from period to period;
| | - |  | ------------------------------------------------------------------------------------------------------------



| |  |  | the initiation, termination, or reduction in the scope of our collaborations or any disputes regarding these collaborations;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------



| |  |  | the timing of our satisfaction of applicable regulatory requirements;
| | - |  | ---------------------------------------------------------------------



| |  |  | the rate of expansion of our clinical development and other internal research and development efforts;
| | - |  | ------------------------------------------------------------------------------------------------------



| |  |  | the effect of competing technologies and products and market developments;
| | - |  | --------------------------------------------------------------------------



| |  |  | the costs and benefits associated with our restructuring;
| | - |  | ---------------------------------------------------------



| |  |  | the costs associated with litigation; and
| | - |  | -----------------------------------------



| |  |  | general and industry-specific economic conditions.
| | - |  | --------------------------------------------------

We believe that quarterly comparisons of our financial results are not necessarily meaningful and should not be relied upon as indications of our future performance.

Relying on third-party manufacturers may result in delays in our clinical trials and product introductions.

We have no manufacturing facilities and have no experience in the manufacturing of drugs or in designing drug-manufacturing processes. We have contracted
with third-party manufacturers to produce, in collaboration with us, our product candidates for clinical trials. If any of our product candidates are approved by the FDA or other regulatory agencies for commercial sale, we may need to contract with
a third party to manufacture them in larger quantities. We currently use third-party manufacturers to produce clinical supplies of our compounds for us, including pimavanserin. While we believe that there are alternative sources available to
manufacture our product candidates, in the event that we seek such alternative sources, we may not be able to enter into replacement arrangements without delays or additional expenditures. We cannot estimate these delays or costs with certainty but,
if they were to occur, they could cause a delay in our development and commercialization efforts.

The manufacturers of our product
candidates are obliged to operate in accordance with FDA-mandated current good manufacturing practices, or cGMPs. A failure of any of our contract manufacturers to establish and follow cGMPs and to document their adherence to such practices may lead
to significant delays in clinical trials or in obtaining regulatory approval of product candidates or the ultimate launch of products based on our product candidates into the market. Failure by our third-party manufacturers or us to comply with
applicable regulations could result in sanctions being imposed on us, including fines, injunctions, civil penalties, failure of the government to grant pre-market approval of drugs, delays, suspension or withdrawal of approvals, seizures or recalls
of products, operating restrictions, and criminal prosecutions.

Our management has broad discretion over the use of our cash and we may not use our
cash effectively, which could adversely affect our results of operations.

Our management has significant flexibility in applying
our cash resources and could use these resources for corporate purposes that do not increase our market value, or in ways with which our stockholders may not agree. We may use our cash resources for corporate purposes that do not yield a significant
return or any return at all for our stockholders, which may cause our stock price to decline.



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We have incurred, and expect to continue to incur, significant costs as a result of laws and regulations relating
to corporate governance and other matters.

Laws and regulations affecting public companies, including the provisions of the
Sarbanes-Oxley Act of 2002, or SOX, and rules adopted or proposed by the SEC and by The Nasdaq Global Market, have resulted in, and will continue to result in, significant costs to us as we evaluate the implications of these rules and respond to
their requirements. We issued an evaluation of our internal control over financial reporting under Section 404 of SOX with our Annual Report. In the future, if we are not able to issue an evaluation of our internal control over financial
reporting as required or we or our independent registered public accounting firm determine that our internal control over financial reporting is not effective, this shortcoming could have an adverse effect on our business and financial results and
the price of our common stock could be negatively affected. New rules could make it more difficult or more costly for us to obtain certain types of insurance, including director and officer liability insurance, and we may be forced to accept reduced
policy limits and coverage or incur substantially higher costs to obtain the coverage that is the same or similar to our current coverage. The impact of these events could also make it more difficult for us to attract and retain qualified persons to
serve on our board of directors and board committees, and as our executive officers. We cannot predict or estimate the total amount of the costs we may incur or the timing of such costs to comply with these rules and regulations.

If we are unable to establish sales and marketing capabilities or enter into agreements with third parties to sell and market any products we may develop, we may
not be able to generate product revenue.

We do not currently have an organization for the sales, marketing and distribution of
pharmaceutical products. In order to market any products that may be approved by the FDA, we must build our sales, marketing, managerial, and related capabilities or make arrangements with third parties to perform these services. If we are unable to
establish adequate sales, marketing, and distribution capabilities, whether independently or with third parties, we may not be able to generate product revenue and may not become profitable.

If we engage in any acquisition, we will incur a variety of costs and may never realize the anticipated benefits of the acquisition.

We may attempt to acquire businesses, technologies, services, or products or license in technologies that we believe are a strategic fit with our
business. We have limited experience in identifying acquisition targets, successfully completing proposed acquisitions and integrating any acquired businesses, technologies, services or products into our current infrastructure. The process of
integrating any acquired business, technology, service, or product may result in unforeseen operating difficulties and expenditures and may divert significant management attention from our ongoing business operations. As a result, we will incur a
variety of costs in connection with an acquisition and may never realize its anticipated benefits.

Earthquake or fire damage to our facilities could
delay our research and development efforts and adversely affect our business.

Our headquarters and research and development
facilities in San Diego are located in a seismic zone, and there is the possibility of an earthquake, which could be disruptive to our operations and result in delays in our research and development efforts. In addition, while our facilities have
not been adversely impacted by local wildfires, there is the possibility of future fires in the area. In the event of an earthquake or fire, if our facilities or the equipment in our facilities is significantly damaged or destroyed for any reason,
we may not be able to rebuild or relocate our facilities or replace any damaged equipment in a timely manner and our business, financial condition, and results of operations could be materially and adversely affected. We do not have insurance for
damages resulting from earthquakes. While we do have fire insurance for our property and equipment located in San Diego, any damage sustained in a fire could cause a delay in our research and development efforts and our results of operations could
be materially and adversely affected.

Risks Related to Our Intellectual Property

Our ability to compete may decline if we do not adequately protect our proprietary rights.

Our commercial success depends on obtaining and maintaining proprietary rights to our product candidates and technologies and their uses, as well as successfully defending these rights against third-party challenges. We will only be able to
protect our product candidates, proprietary technologies, and their uses from unauthorized use by third parties to the extent that valid and enforceable patents, or effectively protected trade secrets, cover them. Although we have filed numerous
patent applications worldwide with respect to pimavanserin, we have been issued only a limited number of patents with respect to these filings.



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Our ability to obtain patent protection for our product candidates and technologies is uncertain due to a
number of factors, including:



| |  |  | we may not have been the first to make the inventions covered by our pending patent applications or issued patents;
| | - |  | -------------------------------------------------------------------------------------------------------------------



| |  |  | we may not have been the first to file patent applications for our product candidates or the technologies we rely upon;
| | - |  | -----------------------------------------------------------------------------------------------------------------------



| |  |  | others may independently develop similar or alternative technologies or duplicate any of our technologies;
| | - |  | ----------------------------------------------------------------------------------------------------------



| |  |  | our disclosures in patent applications may not be sufficient to meet the statutory requirements for patentability;
| | - |  | ------------------------------------------------------------------------------------------------------------------



| |  |  | any or all of our pending patent applications may not result in issued patents;
| | - |  | -------------------------------------------------------------------------------



| |  |  | we may not seek or obtain patent protection in all countries that will eventually provide a significant business opportunity;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------



| |  |  | any patents issued to us or our collaborators may not provide a basis for commercially viable products, may not provide us with any competitive advantages or may be
challenged by third parties;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our proprietary technologies may not be patentable;
| | - |  | ---------------------------------------------------



| |  |  | others may design around our patent claims to produce competitive products which fall outside of the scope of our patents; or
| | - |  | -----------------------------------------------------------------------------------------------------------------------------



| |  |  | others may identify prior art which could invalidate our patents.
| | - |  | -----------------------------------------------------------------

Even if we have or obtain patents covering our product candidates or technologies, we may still be barred from making, using and selling our product candidates or technologies because of the patent rights of others.
Others have or may have filed, and in the future are likely to file, patent applications covering compounds, assays, genes, gene products or therapeutic products that are similar or identical to ours. There are many issued U.S. and foreign patents
relating to genes, nucleic acids, polypeptides, chemical compounds or therapeutic products, and some of these may encompass reagents utilized in the identification of candidate drug compounds or compounds that we desire to commercialize. Numerous
U.S. and foreign issued patents and pending patent applications owned by others exist in the area of central nervous system disorders and the other fields in which we are developing products. These could materially affect our ability to develop our
product candidates or sell our products. Because patent applications can take many years to issue, there may be currently pending applications, unknown to us, that may later result in issued patents that our product candidates or technologies may
infringe. These patent applications may have priority over patent applications filed by us.

We regularly conduct searches to identify
patents or patent applications that may prevent us from obtaining patent protection for our proprietary compounds or that could limit the rights we have claimed in our patents and patent applications. Disputes may arise regarding the ownership or
inventorship of our inventions. It is difficult to determine how such disputes would be resolved. Others may challenge the validity of our patents. If our patents are found to be invalid, we will lose the ability to exclude others from making, using
or selling the inventions claimed therein.

Some of our academic institutional licensors, research collaborators and scientific advisors
have rights to publish data and information to which we have rights. If we cannot maintain the confidentiality of our technology and other confidential information in connection with our collaborations, then our ability to receive patent protection
or protect our proprietary information will be impaired. In addition, technology that we may license in may become important to some aspects of our business. We generally will not control the patent prosecution, maintenance or enforcement of
in-licensed technology.

Confidentiality agreements with employees and others may not adequately prevent disclosure of our trade secrets and other
proprietary information and may not adequately protect our intellectual property, which could limit our ability to compete.

Because
we operate in the highly technical field of drug discovery and development of small molecule drugs, we rely in part on trade secret protection in order to protect our proprietary technology and processes. However, trade secrets are difficult to
protect. We enter into confidentiality and intellectual property assignment agreements with our corporate partners, employees, consultants, outside scientific collaborators, sponsored researchers, and other advisors. These agreements generally
require that the other party keep confidential and not disclose to third parties all confidential information developed by the party or made known to the party by us during the course of the partys relationship with us. These agreements also
generally provide that inventions conceived by the party in the course of rendering services to us will be our exclusive property. However, these agreements may not be honored and may not effectively assign intellectual property rights to us.



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Enforcing a claim that a party illegally obtained and is using our trade secrets is difficult, expensive and time consuming and the outcome is unpredictable.
In addition, courts outside the United States may be less willing to protect trade secrets. The failure to obtain or maintain trade secret protection could adversely affect our competitive position. In addition, we have not entered into any
noncompete agreements with any of our employees.

A dispute concerning the infringement or misappropriation of our proprietary rights or the
proprietary rights of others could be time consuming and costly, and an unfavorable outcome could harm our business.

There is
significant litigation in our industry regarding patent and other intellectual property rights. While we are not currently subject to any pending intellectual property litigation, and are not aware of any such threatened litigation, we may be
exposed to future litigation by third parties based on claims that our product candidates, technologies or activities infringe the intellectual property rights of others. In particular, there are many patents relating to specific genes, nucleic
acids, polypeptides or the uses thereof to identify product candidates. Some of these may encompass genes or polypeptides that we utilize in our drug development activities. If our drug development activities are found to infringe any such patents,
we may have to pay significant damages or seek licenses to such patents. A patentee could prevent us from using the patented genes or polypeptides for the identification or development of drug compounds. There are also many patents relating to
chemical compounds and the uses thereof. If our compounds are found to infringe any such patents, we may have to pay significant damages or seek licenses to such patents. A patentee could prevent us from making, using or selling the patented
compounds. We may need to resort to litigation to enforce a patent issued to us, protect our trade secrets or determine the scope and validity of third-party proprietary rights. From time to time, we may hire scientific personnel formerly employed
by other companies involved in one or more areas similar to the activities conducted by us. Either we or these individuals may be subject to allegations of trade secret misappropriation or other similar claims as a result of their prior
affiliations. If we become involved in litigation, it could consume a substantial portion of our managerial and financial resources, regardless of whether we win or lose. We may not be able to afford the costs of litigation. Any legal action against
us or our collaborators could lead to:



| |  |  | payment of damages, potentially treble damages, if we are found to have willfully infringed a partys patent rights;
| | - |  | --------------------------------------------------------------------------------------------------------------------



| |  |  | injunctive or other equitable relief that may effectively block our ability to further develop, commercialize, and sell products; or
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------



| |  |  | we or our collaborators having to enter into license arrangements that may not be available on commercially acceptable terms, if at all.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------

As a result, we could be prevented from commercializing current or future products.

The patent applications of pharmaceutical and biotechnology companies involve highly complex legal and factual questions, which, if determined adversely to us,
could negatively impact our patent position.

The patent positions of pharmaceutical and biotechnology companies can be highly
uncertain and involve complex legal and factual questions. For example, some of our patent applications will cover gene sequences and products and the uses of those gene sequences and products. Public disclosures and patent applications related to
the Human Genome Project and other genomics efforts may limit the scope of our claims or make unpatentable subsequent patent applications. No consistent policy regarding the breadth of claims allowed in biotechnology patents has emerged to date. The
United States Patent and Trademark Offices standards are uncertain and could change in the future. Consequently, the issuance and scope of patents cannot be predicted with certainty. Patents, if issued, may be challenged, invalidated or
circumvented. U.S. patents and patent applications may also be subject to interference proceedings, and U.S. patents may be subject to reexamination proceedings in the United States Patent and Trademark Office (and foreign patents may be
subject to opposition or comparable proceedings in the corresponding foreign patent office), which proceedings could result in either loss of the patent or denial of the patent application or loss or reduction in the scope of one or more of the
claims of the patent or patent application. In addition, such interference, reexamination and opposition proceedings may be costly. Accordingly, rights under any issued patents may not provide us with sufficient protection against competitive
products or processes.

In addition, changes in or different interpretations of patent laws in the United States and foreign countries may
permit others to use our discoveries or to develop and commercialize our technology and products without providing any compensation to us or may limit the number of patents or claims we can obtain. The laws of some countries do not protect
intellectual property rights to the same extent as U.S. laws and those countries may lack adequate rules and procedures for defending our intellectual property rights. For example, some countries, including many in Europe, do not grant patent claims
directed to methods of treating humans and, in these countries, patent protection may not be available at all to protect our product candidates. In addition, U.S. patent laws may change which could prevent or limit us from filing patent applications
or patent claims to protect our products and/or technologies.



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If we fail to obtain and maintain patent protection and trade secret protection of our product
candidates, proprietary technologies and their uses, we could lose our competitive advantage and competition we face would increase, reducing our potential revenues and adversely affecting our ability to attain or maintain profitability.

Risks Related to Our Industry

We will be subject to
stringent regulation in connection with the marketing of any products derived from our product candidates, which could delay the development and commercialization of our products.

The pharmaceutical industry is subject to stringent regulation by the FDA and other regulatory agencies in the United States and by comparable authorities
in other countries. Neither we nor our collaborators can market a pharmaceutical product in the United States until it has completed rigorous preclinical testing and clinical trials and an extensive regulatory clearance process implemented by the
FDA. Satisfaction of regulatory requirements typically takes many years, depends upon the type, complexity and novelty of the product, and requires substantial resources. Even if regulatory approval is obtained, it may impose significant
restrictions on the indicated uses, conditions for use, labeling, advertising, promotion, and/or marketing of such products, and requirements for post-approval studies, including additional research and development and clinical trials. These
limitations may limit the size of the market for the product or result in the incurrence of additional costs. Any delay or failure in obtaining required approvals could have a material adverse effect on our ability to generate revenues from the
particular product candidate.

Outside the United States, the ability to market a product is contingent upon receiving approval from the
appropriate regulatory authorities. The requirements governing the conduct of clinical trials, marketing authorization, pricing, and reimbursement vary widely from country to country. Only after the appropriate regulatory authority is satisfied that
adequate evidence of safety, quality, and efficacy has been presented will it grant a marketing authorization. Approval by the FDA does not automatically lead to the approval by regulatory authorities outside the United States and, similarly,
approval by regulatory authorities outside the United States will not automatically lead to FDA approval.

In addition, U.S. and foreign
government regulations control access to and use of some human or other tissue samples in our research and development efforts. U.S. and foreign government agencies may also impose restrictions on the use of data derived from human or other tissue
samples. Accordingly, if we fail to comply with these regulations and restrictions, the commercialization of our product candidates may be delayed or suspended, which may delay or impede our ability to generate product revenues.

If our competitors develop and market products that are more effective than our product candidates, they may reduce or eliminate our commercial opportunity.*

Competition in the pharmaceutical and biotechnology industries is intense and expected to increase. We face competition from
pharmaceutical and biotechnology companies, as well as numerous academic and research institutions and governmental agencies, both in the United States and abroad. Some of these competitors have products or are pursuing the development of drugs that
target the same diseases and conditions that are the focus of our drug development programs.

For example, our potential product for
Parkinsons disease psychosis and Alzheimers disease psychosis would compete with off-label use of antipsychotic drugs, including Seroquel, marketed by Astra-Zeneca, and with the generic drug clozapine. In the area of chronic pain,
potential products would compete with Neurontin and Lyrica, marketed by Pfizer, and Cymbalta, marketed by Eli Lilly, as well as a variety of generic or proprietary opioids. Our potential products for the treatment of glaucoma would compete with
Xalatan, marketed by Pfizer, and Lumigan and Alphagan, marketed by Allergan. Our potential products for the treatment of schizophrenia would compete with Zyprexa, marketed by Eli Lilly, Fanapt to be marketed by Vanda Pharmaceuticals, Risperdal,
marketed by Johnson & Johnson, Abilify, marketed jointly by Bristol-Myers Squibb and Otsuka Pharmaceutical, Seroquel, and clozapine. Our potential products for the treatment of sleep maintenance insomnia would compete with Ambien and Ambien
CR, marketed by Sanofi-Aventis, Lunesta, marketed by Sepracor, Sonata, marketed by King Pharmaceuticals, Inc., Rozerem, marketed by Takeda Pharmaceuticals North America, Inc., and various benzodiazepines.

Many of our competitors and their collaborators have significantly greater experience than we do in the following:



| |  |  | identifying and validating targets;
| | - |  | -----------------------------------



| |  |  | screening compounds against targets;
| | - |  | ------------------------------------



| |  |  | preclinical studies and clinical trials of potential pharmaceutical products; and
| | - |  | ---------------------------------------------------------------------------------



| |  |  | obtaining FDA and other regulatory approvals.
| | - |  | ---------------------------------------------



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In addition, many of our competitors and their collaborators have substantially greater capital and
research and development resources, manufacturing, sales and marketing capabilities, and production facilities. Smaller companies also may prove to be significant competitors, particularly through proprietary research discoveries and collaboration
arrangements with large pharmaceutical and established biotechnology companies. Many of our competitors have products that have been approved or are in advanced development and may develop superior technologies or methods to identify and validate
drug targets and to discover novel small molecule drugs. Our competitors, either alone or with their collaborators, may succeed in developing drugs that are more effective, safer, more affordable, or more easily administered than ours and may
achieve patent protection or commercialize drugs sooner than us. Our competitors may also develop alternative therapies that could further limit the market for any drugs that we may develop. Our failure to compete effectively could have a material
adverse affect on our business.

Any claims relating to improper handling, storage, or disposal of biological, hazardous, and radioactive materials
used in our business could be costly and delay our research and development efforts.

Our research and development activities
involve the controlled use of potentially harmful hazardous materials, including volatile solvents, biological materials such as blood from patients that has the potential to transmit disease, chemicals that cause cancer, and various radioactive
compounds. Our operations also produce hazardous waste products. We face the risk of contamination or injury from the use, storage, handling or disposal of these materials. We are subject to federal, state and local laws and regulations governing
the use, storage, handling, and disposal of these materials and specified waste products. The cost of compliance with these laws and regulations could be significant, and current or future environmental regulations may impair our research,
development, or production efforts. If one of our employees were accidentally injured from the use, storage, handling, or disposal of these materials, the medical costs related to his or her treatment would be covered by our workers
compensation insurance policy. However, we do not carry specific biological or hazardous waste insurance coverage and our general liability insurance policy specifically excludes coverage for damages and fines arising from biological or hazardous
waste exposure or contamination. Accordingly, in the event of contamination or injury, we could be subject to criminal sanctions or fines or be held liable for damages, our operating licenses could be revoked, or we could be required to suspend or
modify our operations and our research and development efforts.

Consumers may sue us for product liability, which could result in substantial
liabilities that exceed our available resources and damage our reputation.

Researching, developing, and commercializing drug
products entails significant product liability risks. Liability claims may arise from our and our collaborators use of products in clinical trials and the commercial sale of those products. Consumers may make these claims directly and our
collaborators or others selling these products may seek contribution from us if they receive claims from consumers. Although we currently have product liability insurance that covers our clinical trials, we will need to increase and expand this
coverage as we commence larger scale trials and if our product candidates are approved for commercial sale. This insurance may be prohibitively expensive or may not fully cover our potential liabilities. Inability to obtain sufficient insurance
coverage at an acceptable cost or otherwise to protect against potential product liability claims could prevent or inhibit the commercialization of products that we or our collaborators develop. Product liability claims could have a material adverse
effect on our business and results of operations. Our liability could exceed our total assets if we do not prevail in a lawsuit from any injury caused by our drug products.

Risks Related to Our Common Stock

Our stock price may be particularly volatile because we are a drug discovery
and development company.*

The market prices for securities of biotechnology companies in general, and drug discovery and
development companies in particular, have been highly volatile and may continue to be highly volatile in the future. The following factors, in addition to other risk factors described in this section, may have a significant impact on the market
price of our common stock:



| |  |  | the development status of our product candidates, including results of our clinical trials for pimavanserin or our chronic pain and glaucoma collaborations;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the initiation, termination, or reduction in the scope of our collaborations or any disputes or developments regarding these collaborations;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | market conditions or trends related to biotechnology and pharmaceutical industries, or the market in general;
| | - |  | -------------------------------------------------------------------------------------------------------------



| |  |  | announcements of technological innovations, new commercial products, or other material events by our competitors or us;
| | - |  | -----------------------------------------------------------------------------------------------------------------------



| |  |  | disputes or other developments concerning our proprietary rights;
| | - |  | -----------------------------------------------------------------



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| |  |  | changes in, or failure to meet, securities analysts or investors expectations of our financial performance;
| | - |  | -------------------------------------------------------------------------------------------------------------



| |  |  | additions or departures of key personnel;
| | - |  | -----------------------------------------



| |  |  | discussions of our business, products, financial performance, prospects, or stock price by the financial and scientific press and online investor communities such
as chat rooms;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | public concern as to, and legislative action with respect to, genetic testing or other research areas of biopharmaceutical companies, the pricing and availability
of prescription drugs, or the safety of drugs and drug delivery techniques;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | regulatory developments in the United States and in foreign countries;
| | - |  | ----------------------------------------------------------------------



| |  |  | the announcement of, or developments in, any litigation matters; or
| | - |  | -------------------------------------------------------------------



| |  |  | economic and political factors, including but not limited to economic and financial crises, wars, terrorism, and political unrest.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------

In particular, our Phase III program with pimavanserin for Parkinsons disease psychosis encompasses a number of studies, including two Phase III
pivotal trials, open-label safety extension trials and a range of supporting studies, including carcinogenicity studies, a QTc study, and drug-drug interaction studies. We anticipate completing certain of the studies in this program, including the
first Phase III pivotal trial, during 2009. An unfavorable outcome in one or more of the studies in this program could be a major set-back for our collaboration with Biovail and for our company, generally. Given the recent turmoil in the financial
markets, such an unfavorable outcome could have a material adverse effect on our company and the value of our common stock.

In the past,
following periods of volatility in the market price of a particular companys securities, securities class action litigation has often been brought against that company. We may become subject to this type of litigation, which is often extremely
expensive and diverts managements attention.

If our officers, directors, and largest stockholders choose to act together, they may be
able to significantly influence our management and operations, acting in their best interests and not necessarily those of our other stockholders.

Our directors, executive officers and holders of five percent or more of our outstanding common stock and their affiliates beneficially own a substantial portion of our outstanding common stock. As a result, these
stockholders, acting together, have the ability to significantly influence all matters requiring approval by our stockholders, including the election of all of our board members, amendments to our certificate of incorporation, going-private
transactions, and the approval of mergers or other business combination transactions. The interests of this group of stockholders may not always coincide with the companys interests or the interests of other stockholders and they may act in a
manner that advances their best interests and not necessarily those of our other stockholders.

If we or our stockholders sell substantial amounts of
our common stock, the market price of our common stock may decline.*

A significant number of shares of our common stock are held by
a small number of stockholders. Sales of a significant number of shares of our common stock, or the expectation that such sales may occur, could significantly reduce the market price of our common stock. Holders of a significant number of shares of
our common stock, from investments made when we were a private company, have rights to cause us to file a registration statement on their behalf or include their shares in registration statements that we may file on our behalf or on behalf of other
stockholders. Additionally, in connection with the CEFF, we filed a registration statement with the SEC to register the resale of up to a total of approximately 7.4 million shares of our common stock that may be issued pursuant to the CEFF or
upon exercise of the warrant we issued in connection with establishing the CEFF. In addition, we may elect to file a registration statement to sell shares of our common stock on our own behalf. Our stock price may decline as a result of the sale of
the shares of our common stock included in any of these registration statements.



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Anti-takeover provisions in our charter documents and under Delaware law may make an acquisition of us more
complicated and may make the removal and replacement of our directors and management more difficult.

Our amended and restated
certificate of incorporation and amended and restated bylaws contain provisions that may delay or prevent a change in control, discourage bids at a premium over the market price of our common stock and adversely affect the market price of our common
stock and the voting and other rights of the holders of our common stock. These provisions may also make it difficult for stockholders to remove and replace our board of directors and management. These provisions:



| |  |  | establish that members of the board of directors may be removed only for cause upon the affirmative vote of stockholders owning at least a majority of our capital
stock;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | authorize the issuance of blank check preferred stock that could be issued by our board of directors to increase the number of outstanding shares and
prevent or delay a takeover attempt;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | limit who may call a special meeting of stockholders;
| | - |  | -----------------------------------------------------



| |  |  | establish advance notice requirements for nominations for election to the board of directors or for proposing matters that can be acted upon at stockholder
meetings;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | prohibit our stockholders from making certain changes to our amended and restated certificate of incorporation or amended and restated bylaws except with
66 2/3percent stockholder approval; and
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | provide for a board of directors with staggered terms.
| | - |  | ------------------------------------------------------

We are also subject to provisions of the Delaware corporation law that, in general, prohibit any business combination with a beneficial owner of 15 percent or more of our common stock for 3 years unless the
holders acquisition of our stock was approved in advance by our board of directors. Although we believe these provisions collectively provide for an opportunity to receive higher bids by requiring potential acquirors to negotiate with our
board of directors, they would apply even if the offer may be considered beneficial by some stockholders.

Adverse securities and credit market
conditions have reduced our market capitalization and may significantly affect our ability to raise capital.

The turmoil in the
financial markets has adversely affected the market capitalizations of many biotechnology companies, including us, and generally made equity and debt financing more difficult to obtain. This, coupled with other factors, may limit access to financing
over the near-term future. This could have a material adverse effect on our ability to access funding pursuant to our CEFF or from other sources on acceptable terms, or at all, and our stock price may suffer further as a result.

If the price of our common stock trades below $1.00 per share for a sustained period, our common stock may be delisted from the Nasdaq Global Market.*

The Nasdaq Global Market imposes, among other requirements, listing maintenance standards as well as minimum bid and public float
requirements. In particular, Nasdaq rules require us to maintain a minimum bid price of $1.00 per share of our common stock. Our stock did trade below $1.00 per share earlier in 2009. If the closing bid price of our common stock is below $1.00 per
share for 30 consecutive trading days, we would fail to be in compliance with Nasdaqs continued listing standards and, if we are unable to cure the non-compliance within 180 days, our common stock may be delisted from the Nasdaq Global Market.
In light of the recent volatility in stock prices generally and the continued turbulence in the financial markets, Nasdaq suspended enforcement of the $1.00 minimum bid price requirement through July 31, 2009. Enforcement of the $1.00 minimum
bid price requirement was reinstated on August 3, 2009. If our stock price is below $1.00 per share and remains below that threshold for 30 consecutive trading days after July 31, 2009, we may not be able to maintain the continued listing
of our common stock on the Nasdaq Global Market. Delisting could adversely affect the market liquidity of our common stock and the market price of our common stock could decrease. Such delisting could also adversely affect our ability to obtain
financing for the continuation of our operations.



|ITEM 4. | SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS
|------- | ---------------------------------------------------



|(a) | Our 2009 Annual Meeting of Stockholders was held on June 12, 2009.
|--- | ------------------------------------------------------------------



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|(b) | The election of three nominees to serve as Class II directors on our board of directors until the 2012 Annual Meeting of Stockholders was carried out at the 2009 Annual Meeting of
Stockholders. The following three Class II directors were re-elected by the votes indicated:
|--- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|                  |  |            |  |         
|----------------- |  | ---------- |  | --------
|                  |  | For        |  | Withheld
|Uli Hacksell      |  | 30,765,036 |  | 393,893 
|Torsten Rasmussen |  | 30,711,264 |  | 447,665 
|Alan Walton       |  | 30,842,658 |  | 316,271 

Following the meeting, (x) Michael Borer, Mary Ann Gray and Lester Kaplan continued to serve as Class I
directors, with terms that last until the 2011 Annual Meeting of Stockholders and (y) Gordon Binder, Laura Brege and Leslie Iverson continued to serve as Class III directors, with terms that last until the 2010 Annual Meeting of Stockholders.
As previously announced in our Form 8-K filed on July 28, 2009, Mr. Binder resigned from the board of directors, effective July 23, 2009.



|(c) | In addition to the foregoing election results for the members of our board of directors, the ratification of the appointment of PricewaterhouseCoopers LLP as our independent
registered public accounting firm for the fiscal year ending December 31, 2009 was submitted to our stockholders for approval. This appointment was ratified and approved by the following vote: 31,023,418 votes for and 107,507 votes against,
with 28,006 votes abstaining. For each matter voted upon there were no broker non-votes.
|--- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|ITEM 6. | EXHIBITS
|------- | --------



|              |  |                                                                                                                                                                                                                                   
|------------- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|ExhibitNumber |  | Description of Document                                                                                                                                                                                                           
|              | 
|3.1           |  | Amended and Restated Certificate of Incorporation (filed as Exhibit 3.3 to Registration Statement No. 333-113137).                                                                                                                
|              | 
|3.2           |  | Amended and Restated Bylaws (filed as Exhibit 3.5 to Registration Statement No. 333-113137).                                                                                                                                      
|              | 
|4.1           |  | Form of common stock certificate of Registrant (filed as Exhibit 4.1 to Registration Statement No. 333-52492, dated December 21, 2000).                                                                                           
|              | 
|4.2           |  | Form of Warrant to Purchase Preferred Stock issued to GATX Ventures on May 31, 2002 (filed as Exhibit 4.3 to Registration Statement No. 333-113137).                                                                              
|              | 
|4.3           |  | Form of Warrant to Purchase Common Stock issued to purchasers in a private placement on April 20, 2005 (filed as Exhibit 4.3 to Registration Statement No. 333-124753).                                                           
|              | 
|4.4           |  | Warrant to Purchase Common Stock issued to Kingsbridge Capital Limited on August 4, 2008 (filed as Exhibit 4.4 to Registrants Quarterly Report on Form 10-Q, filed August 7,
2008).                                              
|              | 
|10.1a         |  | Collaboration and License Agreement, dated May 1, 2009, by and among the Registrant and Biovail Laboratories International SRL.                                                                                                   
|              | 
|10.2a         |  | Fourth Amendment to Collaboration Research, Development and License Agreements, dated April 22, 2009, by and among the Registrant, Allergan Sales LLC (as successor in interest of Vision
Pharmaceuticals L.P.) and Allergan, Inc.
|              | 
|31.1          |  | Certification of Uli Hacksell, Ph.D., Chief Executive Officer, pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.                                                                                                         
|              | 
|31.2          |  | Certification of Thomas H. Aasen, Chief Financial Officer, pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.                                                                                                             
|              | 
|32.1          |  | Certification of Uli Hacksell, Ph.D., Chief Executive Officer, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.                                                          
|              | 
|32.2          |  | Certification of Thomas H. Aasen, Chief Financial Officer, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.                                                              



|a | We have applied for confidential treatment of this exhibit with the SEC. The confidential portions of this exhibit are marked with an asterisk and have been omitted
and filed separately with the SEC pursuant to our request for confidential treatment.
|- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.



|                     |  |  |  |                             |  |                                                                                                                                                            
|-------------------- |  |  |  | --------------------------- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------
|                     |  |  |  | ACADIA Pharmaceuticals Inc.
|                     |  |  | 
|Date: August 5, 2009 |  |  |  | By:                         |  | /s/ Uli Hacksell, Ph.D.                                                                                                                                    
|                     |  |  |  |                             |  | Uli Hacksell, Ph.D.                                                                                                                                        
|                     |  |  |  |                             |  | Chief Executive Officer (on behalf of the registrant
and as the registrants Principal Executive Officer)                                                  
|                     |  |  | 
|                     |  |  |  | By:                         |  | /s/ Thomas H. Aasen                                                                                                                                        
|                     |  |  |  |                             |  | Thomas H. Aasen Vice President and Chief Financial
Officer (on behalf of the registrant and as the registrants Principal Financial and Accounting Officer)



32