### FINAL AGENDA FIFRA SCIENTIFIC ADVISORY PANEL (SAP)

OPEN MEETING May 24 -26, 2011 FIFRA SAP WEB SITE http://www.epa.gov/scipoly/sap/ OPP Docket Telephone: (703) 305 - 5805 Docket Number: EPA-HQ - OPP - 2011 - 0284 U.S. Environmental Protection Agency Conference Center - Lobby Level One Potomac Yard (South Bldg.) 2777 S. Crystal Drive, Arlington, VA 22202 Integrated Approaches to Testing and Assessment Strategy : Use of New

Computational and M olecular Tools Please note that all times are approximate (see note at end of Agenda). Tuesday, May 24, 2011 8:30 A.M. Opening of Meeting and Administrative Procedures

Dr. Fred Jenkins, Designated Federal Official, Office of Science Coordination and Policy, EPA 8:35 A.M. Introduction and Identification of Panel Members

Dr. Kenneth Portier, Chair, FIFRA Scientific Advisory Panel 8:40 A.M. Welcome and Opening Remarks

Dr. Steven Bradbury, Director, Office of Pesticide Programs (OPP), EPA 9:00 A.M. OPP’s Vision for an Integrated Approach to Testing and Assessment

Dr. John (Jack) R. Fowle III, Deputy Director, Health Effects Division, OPP, EPA Partnership with ORD to Build a Scientific Foundation for the Vision 9:45 A.M. EPA’s Chemical Safety for Sustainability Research Program

Dr. Elaine Francis, National Program Director for Pesticides and Toxics Research , ORD, EPA 10: 30 A.M. BREAK10:40 A.M. Building Libraries of Adverse Outcome Pathways Dr. Daniel Villeneuve, Aquatic Toxicologist, Toxic Effects Characterization Research Branch, MED, NHEERL , ORD, EPA 12:00 P .M. LUNCH 1: 15 P. M. Building Knowledgebases and Decision Support Tools

Dr. Patricia Schmieder, Chief Molecular and Cellular Mechanisms Research Branch, MED, NHEERL, ORD, EPA Partne rship with Stakeholders 2 : 30 P. M. Partnerships with Stakeholders

– PPDC Workgroup

Kristie Sullivan, MPH , Scientific and Policy Advisor of Physicians Committee for Responsible Medicine 3: 15 P. M. BREAK Case Studies 3: 30 P. M. Introduction to Integration of Toxicogenomic Technology to Inform Risk

Assessment ; A Case Study: Propiconazole Ms. Nancy

McCarroll, Geneticist, RAB VI, Health Effects Division, OPP, EPA 4 : 05 P. M. Integration of Toxicogenomic Technology to Inform Risk Assessment ; A

Case Study: Propiconazole Dr. Stephen Nesnow , Senior Research Scientist, Integrated S ystems Toxicology Division, NHEERL , ORD, EPA 5: 30 P. M. ADJOURNWednesday, May 25, 2011

8:30 A.M. Opening of Meeting and Administrative Procedures

Dr. Fred Jenkins, Designated Federal Official, Office of Science Coordination and Policy, EPA 8:35 A.M. Introduction and Identification of Panel Members

Dr. Kenneth Portier, Chair, FIFRA Scientific Advisory Panel 8:4 5 A.M. Introduction to Use of Adverse Outcome Pathway (AOP) to Inform Risk

Assessment: Triclosan Case Study Dr. Timothy

F. McMahon, Senior Toxicologist, Antimicrobial Division, OPP, EPA 9: 1 5 A.M. Research approach - Mapping the Thryroid AOP for Neurodevelopmental

Effects: Triclosan Case Study Dr. Kevin Crof

ton, Integrated Systems Toxicology Division, NHEERL, ORD, EPA 10: 1 5 A.M. Research approach

– Experimental Studies: Triclosan Case Study

Dr. Tammy Stoker, Research Biologist, Endocrine Toxicology Branch, Toxicity Assessment Division, NHEERL , ORD, EPA 1 1 :1 5 P. M. BREAK 11 : 2 5 P. M. Public Comments 12:00 P.M. LUNCH 1: 1 0 P. M. Public Comments 3: 1 0 P.M. BREAK 3: 20 P. M. Presentation of Charge Questions on OPP’s Strategic Vision

Dr. Jennifer McLain, Deputy Director, Antimicrobial Division, OPP, EPA 3 : 30 P. M. Discussion of Charge Questions 5:30 P.M. ADJOURNThursday, May 26, 2011

8:45 A.M. Opening of Meeting and Administrative Procedures

Dr. Fred Jenkins, Designated Federal Official, Office of Science Coordination and Policy, EPA 8:50 A.M. Introduction and Identification of Panel Members

Dr. Kenneth Portier, Chair, FIFRA Scientific Advisory Panel 9 : 00 A .M. Discussion of Charge Questions (Cont’d for OPP’s Strategic Vision) 10:00 A.M. BREAK 10:10 A.M. Presentation of Charge Questions for Case S tudy I

Dr. Jennifer McLain, Deputy Director, Antimicrobials Division, OPP 10 : 20 A .M. Discussion of Charge Questions 1 2 : 00 A .M. LUNCH 1: 15 P. M. Discussion of Charge Questions (Cont’d for Case Study 1) 2:15 P.M. BREAK 2: 25 P. M. Presentation of Charge Questions for Case Study II

Dr. Timothy

F. McMahon, Senior Toxiciologist, Antimicrobial Division, OPP, EPA 2: 35 P. M. Discussion of Charge Questions 5 : 30 P. M. ADOURN

Please be advised that agenda times are approximate; when the discussion for one topic is completed, discussions for the next topic will begin. For further information, please contact the Designated Federal Official for this meeting, Dr. Fred Jenkins, via telephone: (202) 564

- 3327; fax: (202) 564

- 8382; or email: jenkins.fred@epa.gov