14594 Federal Register / Vol. 72, No. 59 / Wednesday, March 28, 2007 / Notices 

tissue level. It can be utilized in a 

variety of patient populations and 

conditions. For example, the probe can 

be used to monitor the local 

biochemical milieu in soft tissue and 

organ systems to provide insights into 

the pathophysiology of musculoskeletal, 

neuromuscular, rheumatic, 

gastrointestinal, renal, cardiovascular 

and endocrinologic diseases, cancers, 

dermatological conditions, and pediatric 

disorders, especially in premature 

newborns. 

The probe is made from a small-bore 

(32 gauge) needle, whose probe surface 

has been fashioned to permit near 

trauma-less entry, containing both a 

fluid delivery and recovery tube within 

the bore. A molecular exchange 

membrane is positioned about 200 

microns from the tip. Fluid flows across 

the membrane removing diffused 

molecules to a collection device. The 

rounded tip of the needle is designed to 

cause minimal tissue damage while 

allowing investigations to be performed 

on local tissue fluids. Additionally, this 

device allows simultaneous delivery of 

small concentrations of drug. In 

summary, this unique apparatus 

provides a minimally invasive means 

for sampling biological fluids in any 

human or animal organ or tissue and for 

in-situ drug-delivery, in continuous or 

incremental dosing, of extremely small 

doses. 

Applications: Measurement of 

bioavailable substances in organs and 

soft tissues; Localized drug delivery 

vehicle; Measurement of tissue drug 

levels. 

Market: Drug discovery; Tissue/fluid 

sampling; Pain management. 

Inventors: Jay Shah (NIHCC), Terence 

Martyn Phillips (ORS), Jerome V. Danoff 

(NIHCC), Lynn Gerber (NIHCC). 

Publication: JP Shah, TM Phillips, JV 

Danoff, LH Gerber. An in vivo 

microanalytical technique for measuring 

the local biochemical milieu of human 

skeletal muscle. J Appl Physiol. 2005 

Nov; 99(5):1977–1984. Epub 2005 Jul 

21. 

Patent Status: U.S. Provisional 

Application No. 60/795,176 filed 27 Apr 

2006 (HHS Reference No. E–024–2006/ 

0–US–01). 

Licensing Contact: Michael A. 

Shmilovich, Esq.; 301/435–5019; 

shmilovm@mail.nih.gov. 

Fluorescent Intracellular Calcium 

Indicators 

Description of Technology: Calcium is 

a key element in the regulation of many 

cellular processes, including muscle 

contraction, hormone excretion from 

gland cells, neurotransmitter release 

from nerve synapses, and the regulation 

of cellular metabolism. Elevated 

calcium levels are found in a number of 

diseases. 

The present invention relates to 

chromophoric or fluorescent dye 

calcium indicators that are superior for 

measurement of high concentrations of 

calcium ions due to their high 

dissociation constants. As a result of the 

high calcium ion dissociation constants, 

the perturbation resulting from 

introducing the indicator into the cell is 

greatly reduced. These calcium ion 

indicators can be measured by various 

techniques including 19F NMR 

spectroscopy, flow cytometry, and 

quantitative fluorescence techniques, 

and are useful for measuring calcium 

levels within the cytosol or within 

cellular organelles. 

Application: Research tool for 

quantifying intracellular calcium 

concentrations. 

Inventors: Robert E. London, Louis A. 

Levy, and Elizabeth Murphy (NIEHS). 

Patent Status: U.S. Patent Application 

No. 08/175,590 filed 30 Dec 1993, 

which issued as U.S. Patent No. 

5,516,911 on 14 May 1996 (HHS 

Reference No. E–015–1993/0–US–01). 

Licensing Status: Available for 

nonexclusive licensing. 

Licensing Contact: Tara Kirby, PhD; 

301/435–4426; tarak@mail.nih.gov. 

Collaborative Research Opportunity: 

The NIEHS Laboratory of Structural 

Biology is seeking statements of 

capability or interest from parties 

interested in collaborative research to 

further develop, evaluate, or 

commercialize this technology. Please 

contact Dr. Robert London at 919/541–

4879 or london@niehs.nih.gov for more 

information. 

Dated: March 19, 2007. 

Steven M. Ferguson, 

Director, Division of Technology Development 

and Transfer, Office of Technology Transfer, 

National Institutes of Health. 

[FR Doc. E7–5676 Filed 3–27–07; 8:45 am] 

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National Center on Minority Health and 

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Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. Appendix 2), notice 

is hereby given of the following 

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The meetings will be closed to the 

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provisions set forth in sections 

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the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

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invasion of personal privacy. 

Name of Committee: National Center on 

Minority Health and Health Disparities 

Special Emphasis Panel, LRP for Health 

Disparities and Clinical Research-Panel B. 

Date: April 29, 2007. 

Time: 9 a.m. to 5 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6707 

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20892, (Virtual Meeting). 

Contact Person: Lorrita Watson, PhD, 

National Center on Minority Health, and 

Health Disparities, National Institutes of 

Health, 6707 Democracy Blvd., Suite 800, 

Bethesda, MD 20892–5465, (301) 402–1366, 

watsonl@ncmhd.nih.gov. 

Name of Committee: National Center on 

Minority Health and Health Disparities 

Special Emphasis Panel, NCMHD Conference 

Grant Application (R13) Review. 

Date: May 1, 2007. 

Time: 8 a.m. to 5 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, Two 

Democracy Plaza, 6707 Democracy 

Boulevard, Bethesda, MD 20892, (Virtual 

Meeting). 

Contact Person: Robert Nettey, MD, 

Scientific Review Administrator, National 

Institute on Minority Health, and Health 

Disparities, 6707 Democracy Blvd., Suite 800, 

Bethesda, MD 20892, 301–496–3996. 

Dated: March 21, 2007. 

Jennifer Spaeth, 

Director, Office of Federal Advisory 

Committee Policy. 

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DEPARTMENT OF HEALTH AND 

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National Eye Institute, Notice of Closed 

Meeting 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. Appendix 2), notice 

is hereby given of the following 

meeting. 

The meeting will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 


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