UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 

## JUN 21 2012

MEMORANDUM OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION
SUBJECT: FROM:

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TO: BEAD Chemical Profile for Registration Review: Folpet (081601) Leonard Yourman, Plant Pathologist 

# [>**~** Biological Analysis Branch 

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_ .. Jihad Alsadek, Economist

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# tt~ Science Information and Analysis Branch

Arnet Jones, Chief Biological Analysis Branch Diann Sims, Chief

## ;L.Iil**~.A..o .,,/~,,-,'"L.Ll~I"\..-c:~**  Science Information and Analysis Branch Timothy Kiely, Chief 

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# ~ Economic Analysis Branch \/'""''-- Biological and Economic Analy' Division (7 3 Christina Scheltema, Chemical Review Manager Risk Management and Implementation Branch 3 Pesticide Re-evaluation Division (7508P)

Product Review Panel date: June 6, 2012

INTRODUCTION The purpose ofthis document is to convey usage information and a broad overview ofthe pest management roles ofpesticides that are beginning to undergo registration review. The anticipated audience consists ofthe team ofEPA staffcurrently evaluating the registration status offolpet, and eventually the general public. The document is based oninformation and data available to BEAD as ofJune, 2012.



### 1Folpet (Folpan®) is a thiophthalimide fungicide. Folpet and captan are the only two fungicides ofthat group registered inthe U.S. Folpet has multi-site contact mode ofaction (FRAC, 2012).

COMMON FORMULATIONS AND APPLICATION METHODS Folpet is formulated as water dispersible granules or wettable powder for use as a foliar treatment ofavocado and hops. Itis also formulated with bis (tributyltin) oxide for use as a wood decay preventative (Fishel, 2011). There are nine end use antimicrobial products that contain folpet. Three products are wood preservatives and six products are materials preservatives. The wood preservativeproducts are formulated as ready to use liquids that are applied using brush, roller or airless spray. The material preservative products are formulated as liquid concentrates, wettable powders and water dispersible granules that are added during material manufacture. The wood preservative products contain other active ingredients such as bis (tributyltin) oxide or 3-iodo-2-propynl butyl carbmate (IPBC). The material preservative products do not contain any other active ingredients.

USE SITES Agricultural Use Sites Folpet is registered for use on avocados inFloridato manage scab and for use onhops to manage downy mildew. Non-Agricultural Use Sites Folpet is registered for use onthe following non-agricultural sites; domestic dwellings (outdoor), wood and wood structure protection, industrial preservatives, adhesives, caulks, coatings, paints, plastics, stains,**~ood** plastic composites, surface treatments (outdoor furniture, tile, finished wood, plaster, wood surface), and polymer compounds. Polymer compound uses are limited to non-food and non-drinking water articles. These uses are notto be used intoys, personal care items, or clothing. A summary ofthe application rates is listed in Table 1.

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### Table 1 - FolpetAntimicrobialUses Use Application Rate Representative (In Terms ofai) Label MaterialsPreservation Adhesives, caulks, cementbased products, plastics, paper 0.2 to 1.4 percent 66222-126 and wood composite materials

Paints, stains and coatings 0.4 to 1.4 percent 66222-125 PVC membranes, roofshingles, carpets, cordage, gaskets, 0.25 to 1.5 percent vinyl upholstery, pond liners Wood Preservative

Clearwood Preservative 0.50 percent (coverage 150 to 250 

### :tf gallon) 73l3-25 Sherwin Williams Semi-transparent Wood Preservative 0.66 percent (coverage 100 to 350 

### :tf gallon) 577-539 Olympic Clear Wood Preservative 0.50percent 7313-6 (coverage 150 to 250 

### :tf gallon


### HISTORY OFBEAD ASSESSMENTS FORFOLPET There are no recent BEAD assessments that are relevantto the review ofthis chemical.



### USAGE Folpet is a fungicide used as a foliar treatment to manage scab on avocados in Florida and downy mildew onhops. Italso has uses against wood rot fungi, mold/mildew, and spoilage fungi on wood and other surfaces. Formulations include liquid, ready to use, 0.3 to 0.7%; wettable powder, 44 to 50%; and 96% technical for industrial use. There is no available'usage for folpet from our data sources 

### Antimicrobial Usage The 200412005 Kline Report on Specialty Biocides (Kline, 2006) indicates that folpet is used as a fungicide in paints and coatings and as a fungicide/mildewcide in adhesives and sealants. The estimated U.S. consumption for 2004 was 700,000 lb ofwhich 630,000 pounds were used 

### in paints and coatings and 70,000 pounds were used 

### inadhesives and sealants. These uses were predicted to grow at an annual rate of3.0percent. Inthe paints and coatings product class for fungicides, folpet consumption was 14 percent ofthe volume and 9 percent ofthe value. Inthe adhesives and sealants product class for fungicide/mildewcide, folpet consumption was 18 percent ofthe volume and 4 percent ofthe value.



### BIOLOGICAL ASPECTS RELEVANT TO FOLPET According to extension information for hops, it is often used as a tank-mix with a systemic fungicide to manage downy mildew (Pseudoparonospora humulis) and reduce the likelihood of resistance to site-specific systemic fungicides (e.g., cymoxanil) (Hops, 2008). It may also suppress powdery mildew onhops, but it is not widely used for powdery mildew as efficacy is not well described. Alternatives appear to be available.

3Folpet may be used to manage scab (Sphacelomaperseae) on avocado (the label restricts its use to Florida). The disease primarily affects young plants, but cultivars ofFlorida avocado vary greatly intheir susceptibilityto scab, ranging from very susceptible to slightly susceptible in mature trees (Crop Profiles for Avocados in Florida, 2008; Palmateer et al., 2006). Copper products and phosphoric acid products appear to be effective for managing scab.

INFORMATION THAT MAY BE USEFUL FORBEAD'S FUTURE WORK ON FOLPET
Additional information on non-agricultural sites; domestic dwellings (outdoor), wood and wood structure protection, industrial preservatives, surface treatments (outdoor furniture, tile, finished wood, plaster, wood surface, paint) would improve future BEAD assessments ofthe importance offolpet, and may be required as part ofthe registration review ofthis pesticide. Usage information (e.g., acres treated, amount applied, number ofapplications, etc.) for Florida avocado and for hops will be helpful iffuture assessments are necessary.

REFERENCES Crop Profiles for Avocados in Florida. 2008. http://www.ipmcenters.org/ cropprofiles/docs/FLavocados.pdf Fishel, F. M. 2011. Pesticide Toxicity Profile: Thiophthalimide Pesticides. University ofFlorida Extension Pub!. PI-63. http://edis.ifas.ufl.edulpdffilesIPIIPIlOOOO

.pdf Folpet. 1999. R.E.D. (Registration Eligibility Decision) Fact Sheet: Folpet. EPA Pub!. EPA-738- FOO-016, September, 1999. http://www.epa.gov/oppsrrd1IREDs/factsheets/0630fact.pdf FRAC (Fungicide Resistance Action Committee). 2012. FRAC Code List: Fungicides sorted by mode ofaction. http:/ /www.frac.info/frac/publicationlanhang/FRAC-Code-List2011-fina!.pdf Hops. 2008. Pest Management Strategic Plan for Hops in Oregon, Washington, and Idaho. Western Integrated PestManagement Center summary ofworkshop held onJanuary 22, 2008 (issued July 3, 2008). http://www.ipmcenters.orglpmsplpdf/OR-WA-IDhopsPMSP.pdf

. Kline. 2006. Biocides-Chapter 3E Organosulfur; Chapter 4A5-6 Paint and Coatings Palmateer, A. J., Ploetz, R. C., and Harmon, P. F. 2006. 2006 Florida Plant Disease Management Guide: Avocado (Persea americana). University ofFloridaExtension Pub!. PP-233. http://edis.ifas.ufl.edulpdffiles/PG/PG13400.pdf



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