Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 

PC Code: 118602 

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY AND 

 POLLUTION PREVENTION

MEMORANDUM

DATE: 28-June-2010 

SUBJECT: Imazosulfuron: Acute and Chronic Aggregate Dietary (Food and 

Drinking Water) Exposure and Risk Assessments for the New Uses on 

Peppers, Rice, and Tomato 

PC Code: 118602 DP Barcode: D367020 

Decision No.: 406200 Registration No.: 59639-RLU, 59639-RLL, 

59639-RAA 

Petition No.: 9F7535 Regulatory Action: Section 3 Registration 

Risk Assessment Type: Single Chemical Case No.: NA 

TXR No.: NA CAS No.: 122548-33-8

MRID No.: NA 40 CFR: Pending 

REVIEWER: Cassi L. Walls, Ph.D., Senior Biologist 

 Risk Assessment Branch III/Health Effects Division (HED; 7509P) 

THROUGH: Toiya Goodlow, Chemist 

Meheret Negussie, Chemist 

Dietary Exposure Science Advisory Council (DESAC)/HED (7509P) 

TO: Sheila Healy, Risk Assessor 

Risk Assessment Branch III/HED (7509P) 

and 

James Thompson, RM Team 25 

Herbicide Branch/Registration Division (RD; 7505P) 

Executive Summary

Acute and chronic aggregate dietary (food and drinking water) exposure and risk 

assessments were conducted for the herbicide, imazosulfuron, using the Dietary Exposure 

Evaluation Model (DEEM-FCIDTM), Version 2.03 which use food consumption data 

from the U.S. Department of Agriculture’s Continuing Surveys of Food Intakes by 

Individuals (CSFII) from 1994-1996 and 1998. The analyses were performed to support 

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Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 

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a Section 3 Registration petition on peppers, rice, and tomatoes. Imazosulfuron is 

currently registered for use on turf grass and ornamentals. However, this is the first 

food/feed use request for imazosulfuron. 

Acute Dietary Exposure Results and Characterization

An unrefined dietary assessment was conducted assuming that 100% of crops with the 

requested uses of imazosulfuron are treated and that all treated crops contain residues at 

tolerance level. In addition, default processing factors were assumed for the requested 

crop uses. Potential residues in drinking water were included in the analyses based on 

surface water results from the RICE model as these values were higher than the 

groundwater estimates from the Screening Concentration in Ground Water (SCI-GROW) 

model (D362654 Faruque Khan, 13-MAY-2010). Thus, the results obtained from the 

present analyses may be considered highly conservative. No population subgroups 

exceed HED’s level of concern at the 95th percentile of exposure for food and drinking 

water. The U.S. population occupied < 1% of the acute population-adjusted dose 

(aPAD), while the most highly exposed population subgroup, all infants (< 1 year old), 

occupied 1.4% of the aPAD. For food alone, the U.S. population and the most highly 

exposed population subgroup, children 1-2 years old, both occupied < 1% of the aPAD 

Chronic Dietary Exposure Results and Characterization

An unrefined chronic dietary assessment was conducted assuming that 100% of crops 

with the requested uses of imazosulfuron are treated and that all treated crops contain 

residues at tolerance level. In addition, default processing factors were assumed for the 

requested crop uses. Potential residues in drinking water were included in the analyses 

based on surface water results from the RICE model as these values were higher than the 

groundwater estimates from the SCI-GROW model. No population subgroups exceed 

HED’s level of concern for dietary exposure from food and drinking water: the U.S. 

population occupied < 1% of the chronic population-adjusted dose (cPAD), while the 

most highly exposed population subgroup, all infants (< 1 year old), occupied 2.7% of the 

cPAD. No population subgroups exceed HED’s level of concern for dietary exposure 

from food alone: the U.S. population and the most highly exposed population subgroup, 

Children 1-2 years old, both occupied < 1% of the cPAD. 

Cancer Dietary Exposure Results and Characterization

A determination of cancer risk was not performed with DEEM-FCIDTM as part of the 

present assessment, since this chemical was classified as “Not likely to be Carcinogenic 

to Humans” based on negative genotoxicity and carcinogenicity in long term cancer 

studies in rats and mice. Therefore, a cancer dietary assessment for imazosulfuron is not 

required. 

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Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 

PC Code: 118602 

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I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For 

acute and chronic assessments, the risk is expressed as a percentage of a maximum 

acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable 

adverse health effects). This dose is referred to as the population-adjusted dose (PAD). 

The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, e.g.) divided by 

the required uncertainty or safety factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary 

risk exceeds 100% of the PAD. References which discuss the acute and chronic risk 

assessments in more detail are available on the EPA/pesticides web site: “Available 

Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, 

web link: http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see 

SOP 99.6 (20-AUG-1999). 

This is the first dietary assessment for imazosulfuron as it is first food/feed use request. 

II. Residue Information

Imazosulfuron is a new sulfonylurea herbicide being developed by Valent U.S.A 

Corporation for control of broad-leaf weeds and sedges. The mode of action of 

imazosulfuron is inhibition of the enzyme acetolactate synthase. Tolerances are 

requested for the residue of imazosulfuron (2-chloro-N-[[(4,6-dimethoxy-2-

pyrimidinyl)amino]carbonyl]imidazo[1,2-α]pyridine-3-sulfonamide) 

in/on peppers at 0.02 ppm; tomato at 0.02 ppm; and rice at 0.02 ppm. These tolerances 

were requested by Valent, as well as, recommended by HED. 

The HED Residues of Concern Knowledge-based Subcommittee (ROCKS) reviewed and 

discussed potato, rice, tomato, rotational crops, and livestock studies for the 

imazosulfuron, as well as toxicological and environmental fate data, for determination of 

the residues of concern (19-MAY-2010). HED has determined that the residue of 

concern in crop commodities for tolerance enforcement assessment is imazosulfuron, 

whereas, the residue of concern for risk assessment is the sum of imazosulfuron and its 

metabolite, 4,6-dimethoxy-2-ureidopyrimidine (UDPM) (D377141, Edward Scollon, 01-

JUNE-2010). Residue information for the proposed food commodities included in the 

present analyses was taken from the imazosulfuron residue chemistry memo (D367019, 

Stephen Funk, 06-JUNE-2010). 

For both the acute and chronic dietary analyses, the recommended tolerances and default 

processing factors were used for each food commodity residue level. The acute and 

chronic assessments also assume that 100% of the crops are treated. Table 1 summarizes 

the imazosulfuron residue levels for the proposed crops used in the acute and chronic 

dietary assessments. 

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Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 

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Table 1. Summary of Imazosulfuron Residue Levels Used in Acute and Chronic Analyses. 

Matrix Residue Level 

[Acute and Chronic] (ppm)* 

Default Processing Factors 

Pepper 0.04 

Rice, grain 0.04 

Tomato 0.04 Tomato paste = 5.4; 

Tomato puree = 3.3; 

Tomato, dried = 14.3; 

Tomato juice = 1.5 

* The residue level of 0.04 ppm used in the assessments is the sum of the imazosulfuron proposed tolerance 

(0.02ppm) and its UDPM metabolite (0.02 ppm) 

III. Drinking Water Data 

The drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED) (D362654 Faruque Khan, 13-MAY2010). Water residues bolded in Table 2 were directly incorporated in the DEEM-FCID 

into the food categories “water, direct, all sources” and “water, indirect, all sources.” 

Table 2. Tier I EDWCs for Imazosulfuron Applications

Drinking Water 

Source 

Model Use rate (lbs 

ai/A/year) 

Acute (μg/L) Chronic (μg/L) 

Surface water RICE 0.3 278.9 278.9 

Groundwater SCI-GROW 1.34 4.8 4.8 

Surface Water. The highest estimated drinking water concentration (EDWC) for 

imazosulfuron resulted from the Tier I RICE model. This recommended EDWC of 278.9

μg/L is based on aerial spray application of 0.3 lbs. a.i./A per year for rice. 

Groundwater. In lieu of sufficient groundwater monitoring data for imazosulfuron, the 

Tier 1 groundwater screening model SCI-GROW was used to estimate concentration of 

imazosulfuron in groundwater sources. Turf grass applications with an annual use rate of 

1.34 lbs ai/A/year was used in the modeling and resulted in a groundwater EDWC of 4.8 

μg/L. 

Because the acute and chronic surface water estimates were higher than the groundwater 

estimates, the present analyses made use of the former values, expressed to two 

significant figures and converted into the proper units for the DEEM program (mg/L or 

ppm). 

IV. DEEM-FCIDTM Program and Consumption Information

Imazosulfuron acute and chronic dietary exposure assessments were conducted using the 

DEEM-FCIDTM version 2.03 modeling software. It uses food consumption data from the 

U.S. Department of Agriculture (USDA) CSFII 1994-1996 and 1998 food intake surveys. 

The 1994-96, 98 data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) 

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Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 

PC Code: 118602 

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are linked to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or 

N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe 

translation files developed jointly by USDA/ARS and EPA. For chronic exposure 

assessment, consumption data are averaged for the entire US population and within 

population subgroups. Based on analysis of the 1994-96, 98 CSFII consumption data, 

which took into account dietary patterns of survey respondents, HED concluded that it is 

most appropriate to report risk for the following population subgroups: the general U.S. 

population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-

19, adults 20-49, females 13-49, and adults 50+ years old. 

For chronic dietary exposure assessments, an estimate of the residue level in each food or 

food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied 

by the average daily consumption estimate for that food/food form to produce a residue 

intake estimate. The resulting residue intake estimate for each food/food form is summed 

with the residue intake estimates for all other food/food forms on the commodity residue 

list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg 

body weight/day and as a percent of the cRfD. This procedure is performed for each 

population subgroup. 

For acute exposure assessments, individual one-day food consumption data are used on 

an individual-by-individual basis. The reported consumption amounts of each food item 

can be multiplied by a residue point estimate and summed to obtain a total daily pesticide 

exposure for a deterministic exposure assessment, or “matched” in multiple random 

pairings with residue values and then summed in a probabilistic assessment. The 

resulting distribution of exposures is expressed as a percentage of the aPAD on both a 

user (i.e., only those who reported eating relevant commodities/food forms) and a percapita (i.e., those who reported eating the relevant commodities as well as those who did 

not) basis. In accordance with HED policy, per capita exposure and risk are reported for 

all tiers of analysis. 

V. Toxicological Information 

All information specific to the toxicity characteristics of imazosulfuron are presented in 

the most recent risk assessment supporting the turf grass and ornamental uses (D348001, 

Sheila Healy et. al., 13-MARCH-2009). For the acute and chronic exposure scenarios, 

the standard 100 fold UF was applied to account for inter-species extrapolation and intraspecies variation. The FQPA Safety Factor be reduced to 1X because there is an 

adequate toxicity database for imazosulfuron; there is no evidence of susceptibility 

following in utero and/or postnatal exposure in the developmental toxicity studies in rats 

or rabbits, or in the 2-generation rat reproduction study and there are no residual 

uncertainties concerning pre- and postnatal toxicity and no neurotoxicity concerns. As 

previously noted, a cancer risk evaluation is not included in this assessment. To provide 

an overview of the toxicological profile, a summary of the doses and endpoints selected 

for the relevant dietary exposure scenarios is provided in Table 3. 

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Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 

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Table 3. Summary of Toxicological Doses and Endpoints for Imazosulfuron for Use in Dietary 

Exposure Risk Assessments 

Exposure/ 

Scenario 

Point of 

Departure 

Uncertainty/FQPA 

Safety Factors 

RfD, PAD, Level 

of Concern 

Study and Toxicological 

Effects 

Acute 

Dietary (All 

Populations) 

NOAEL = 

400 

mg/kg/day 

UFA = 10x 

UFH = 10x 

FQPA SF = 1x 

aRfD = 4 

mg/kg/day 

aPAD = 4 

mg/kg/day 

Acute neurotoxicity screening 

battery (MRID 47305319). 

LOAEL = 2000 mg/kg/day 

based on based on the following 

clinical signs: abnormal gait, 

decreased activity, piloerection 

and upward curvature of the 

spine; and incidents of irregular 

breathing, reduced righting 

reflex, tremors, decreased 

visual placement response in 

males and increased response to 

sound in one female. 

Chronic 

Dietary (All 

Populations) 

NOAEL = 

75 

mg/kg/day 

UFA = 10x 

UFH = 10x 

FQPA SF= 1x 

cRfD = 0.75 

mg/kg/day 

cPAD = 0.75 

mg/kg/day 

Chronic toxicity (dog; MRID 

47305305) 

LOAEL = 150 mg/kg/day based 

on based on increased relative 

liver weights, increased serum 

alkaline phosphatase activity 

and moderate thyroid 

hypertrophy (males only at 

mid-dose 

Cancer Classification: “Not likely to be Carcinogenic to Humans” based on the 

absence of significant tumor increases in two adequate rodent carcinogenicity 

studies (MRID 47305307, mouse; 47305306, rat). 

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA = extrapolation from animal to human (intraspecies). UFH = potential variation in sensitivity 

among members of the human population (interspecies). FQPA SF = FQPA Safety Factor. PAD = population-adjusted 

dose (a = acute, c = chronic). RfD = reference dose. 

VI. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk 

exceeds 100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure 

of the U.S. population and various population subgroups. The results reported in Table 4 

are for the general US Population, all infants (<1 year old), children 1-2, children 3-5, 

children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+ years. 

Results of Acute and Chronic Dietary (Food and Drinking Water) Exposure Analysis

Acute dietary risk analyses were conducted with the DEEM-FCIDTM model to form a 

conservative evaluation of exposure for imazosulfuron. At the 95th percentile of 

exposure, all acute analyses yielded risk estimates well below the 100% of the aPAD 

threshold level of concern for each population subgroup. For food and drinking water, 

the U.S. Population subgroup acute aggregate dietary risk was calculated at <1% of the 

aPAD with an exposure level of 0.015 mg/kg/day. For the subgroup with the highest 

calculated exposure, all infants, acute aggregate dietary risk occupied 1.4% of the aPAD 

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Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 

PC Code: 118602 

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with an exposure of 0.06 mg/kg/day. For the U.S. Population subgroup, acute dietary 

risk for food only was calculated at <1% of the aPAD with an exposure level of 0.00033 

mg/kg/day. For the subgroup with the highest calculated exposure, Children 1-2 years 

old, acute food only dietary risk occupied 0.02% of the aPAD with an exposure of 

0.00090 mg/kg/day. An overview summarizing the results of the acute dietary 

assessments with the population subgroup having the highest exposure noted in bold is 

presented in Table 4. 

Chronic dietary risk analyses were conducted with the DEEM-FCIDTM model to form a 

conservative evaluation of exposure for imazosulfuron. All chronic analyses yielded risk 

estimates well below the 100% of the cPAD threshold level of concern for each 

population subgroup. For food and drinking water, the U.S. Population subgroup chronic 

aggregate dietary risk was calculated at <1% of the cPAD with an exposure level of 

0.0060 mg/kg/day. For the subgroup with the highest calculated exposure, all infants, 

chronic aggregate dietary risk occupied 2.7% of the cPAD with an exposure of 0.020 

mg/kg/day. For the U.S. Population subgroup, chronic dietary risk for food only was 

calculated at <1% of the cPAD with an exposure level of 0.000084 mg/kg/day. For the 

subgroup with the highest calculated exposure, all infants, chronic food only dietary risk 

occupied <1% of the cPAD with an exposure of 0.00020 mg/kg/day. An overview 

summarizing the results of the chronic dietary assessment with the population subgroup 

having the highest exposure noted in bold is presented in Table 4. 

Table 4. Result of Acute and Chronic Dietary Exposure and Risk Estimates for Imazosulfuron.

DEEM-FCID (food only) DEEM-FCID (food and water) 

Population Subgroup PAD, 

mg/kg/day Exposure, 

mg/kg/day % PAD* Exposure, mg/kg/day %PAD* 

Acute Dietary Estimates (95th Percentile of Exposure)

U.S. Population 0.000333 <1 0.014919 <1 

All infants (< 1 yr) 0.000367 <1 0.056034 1.4 

Children 1-2 yrs 0.000896 <1 0.023470 <1 

Children 3-5 yrs 0.000739 <1 0.021335 <1 

Children 6-12 yrs 0.000494 <1 0.014925 <1 

Youth 13-19 yrs 0.000313 <1 0.012125 <1 

Adults 20-49 yrs 0.000277 <1 0.013800 <1 

Adults 50+ yrs 0.000236 <1 0.012433 <1 

Females 13-49 yrs 

4.0 

0.000259 <1 0.013772 <1 

Chronic Dietary Estimates

U.S. Population 0.000084 <0.01 0.006043 <1 

All infants (< 1 yr) 0.000069 <0.01 0.019881 2.7 

Children 1-2 yrs 0.000200 <0.01 0.009043 1.2 

Children 3-5 yrs 0.000178 <0.01 0.008433 1.1 

Children 6-12 yrs 0.000121 <0.01 0.005811 <1 

Youth 13-19 yrs 0.000085 <0.01 0.004372 <1 

Adults 20-49 yrs 

0.75 

0.000074 <0.01 0.005638 <1 

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Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 

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Table 4. Result of Acute and Chronic Dietary Exposure and Risk Estimates for Imazosulfuron.

DEEM-FCID (food only) DEEM-FCID (food and water) 

Population Subgroup PAD, 

mg/kg/day Exposure, 

mg/kg/day % PAD* Exposure, mg/kg/day %PAD* 

Adults 50+ yrs 0.000056 <0.01 0.005918 <1 

Females 13-49 yrs 0.000069 <0.01 0.005605 <1 

* % PADs are reported to 2 significant figures. The values for the highest population for each type of risk 

assessment are bolded. 

VII. Characterization of Inputs/Outputs 

The acute and chronic dietary assessments conducted with DEEM-FCIDTM for 

imazosulfuron is an unrefined analysis. In addition to tolerance level residues, default 

processing factors, and 100% crop treated assumptions, it utilized conservative EDWCs 

derived through EFED modeling which are unlikely to underestimate the concentration of 

imazosulfuron in drinking water. The present DEEM-FCIDTM analysis assumes that all 

drinking water will contain imazosulfuron at the highest acute EDWC levels modeled by 

EFED for groundwater or surface water. For these reasons, it can be concluded that the 

DEEM-FCIDTM analysis does not underestimate risk from acute and chronic exposure to 

imazosulfuron for the general U.S. population and all its subgroups. 

VIII. Conclusions

The conservative acute and chonic dietary risk assessment conducted with DEEMFCIDTM indicates that exposures to imazosulfuron are below HED’s level of concern. 

The acute dietary risk to imazosulfuron is estimated to be <1.0% of the aPAD for the 

general U.S. population and 1.4% of the aPAD for the most highly exposed population 

subgroup, all infants (<1year old). The chronic dietary risk to imazosulfuron is estimated 

to be <1.0% of the cPAD for the general U.S. population and 2.7% of the cPAD for the 

most highly exposed population subgroup, all infants (<1year old). Therefore, HED does 

not have any concerns for the proposed new tolerances of imazosulfuron. 

IX. List of Attachments 

1. Attachment 1: Acute Dietary Exposure (food + water) Input File. 

2. Attachment 2: Acute Dietary Exposure (food + water) Results File. 

3. Attachment 3: Acute Dietary Exposure (food only) Results File. 

4. Attachment 4: Chronic Dietary Exposure (food + water) Input File. 

5. Attachment 5: Chronic Dietary Exposure (food + water) Results File. 

6. Attachment 6: Chronic Dietary Exposure (food only) Results File. 
Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 

PC Code: 118602 

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ATTACHMENT 1 

U.S. Environmental Protection Agency Ver. 2.02 

DEEM-FCID Acute analysis for IMAZASULFURON 

Residue file name: C:\Documents and Settings\cwalls\My 

Documents\Cassi\HED\Imazasulfuron\imazasulfuron food and water.R98 

Analysis Date 06-22-2010 Residue file dated: 06-22-2010/10:24:18/8 

Reference dose (aRfD) = 4 mg/kg bw/day 

Comment: food and water 

-------------------------------------------------------------------------------- 

 EPA Crop Def Res Adj.Factors Comment 

 Code Grp Food Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ ------- 

08002700 8 Pepper, bell 0.040000 1.000 1.000 

08002701 8 Pepper, bell-babyfood 0.040000 1.000 1.000 

08002710 8 Pepper, bell, dried 0.040000 1.000 1.000 

08002711 8 Pepper, bell, dried-babyfood 0.040000 1.000 1.000 

08002720 8 Pepper, nonbell 0.040000 1.000 1.000 

08002721 8 Pepper, nonbell-babyfood 0.040000 1.000 1.000 

08002730 8 Pepper, nonbell, dried 0.040000 1.000 1.000 

15003230 15 Rice, white 0.040000 1.000 1.000 

15003231 15 Rice, white-babyfood 0.040000 1.000 1.000 

15003240 15 Rice, brown 0.040000 1.000 1.000 

15003241 15 Rice, brown-babyfood 0.040000 1.000 1.000 

15003250 15 Rice, flour 0.040000 1.000 1.000 

15003251 15 Rice, flour-babyfood 0.040000 1.000 1.000 

15003260 15 Rice, bran 0.040000 1.000 1.000 

15003261 15 Rice, bran-babyfood 0.040000 1.000 1.000 

08003740 8 Tomatillo 0.040000 1.000 1.000 

08003750 8 Tomato 0.040000 1.000 1.000 

08003751 8 Tomato-babyfood 0.040000 1.000 1.000 

08003760 8 Tomato, paste 0.040000 5.400 1.000 

08003761 8 Tomato, paste-babyfood 0.040000 5.400 1.000 

08003770 8 Tomato, puree 0.040000 3.300 1.000 

08003771 8 Tomato, puree-babyfood 0.040000 3.300 1.000 

08003780 8 Tomato, dried 0.040000 14.300 1.000 

08003781 8 Tomato, dried-babyfood 0.040000 14.300 1.000 

08003790 8 Tomato, juice 0.040000 1.500 1.000 

86010000 O Water, direct, all sources 0.278900 1.000 1.000 

86020000 O Water, indirect, all sources 0.278900 1.000 1.000
Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 

PC Code: 118602 

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ATTACHMENT 2

U.S. Environmental Protection Agency Ver. 2.02 

DEEM-FCID ACUTE Analysis for IMAZASULFURON (1994-98 data) 

Residue file: imazasulfuron food and water.R98 Adjustment factor #2 NOT used. 

Analysis Date: 06-22-2010/10:01:25 Residue file dated: 06-22-2010/09:49:28/8 

Daily totals for food and foodform consumption used. 

Run Comment: "food and water" 

=============================================================================== 

Summary calculations (per capita): 

 95th Percentile 99th Percentile 99.9th Percentile 

 Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- -------- 

U.S. Population: 

 0.014919 0.37 0.027950 0.70 0.056118 1.40 

All infants: 

 0.056034 1.40 0.080087 2.00 0.144512 3.61 

Children 1-2 yrs: 

 0.023470 0.59 0.039257 0.98 0.056476 1.41 

Children 3-5 yrs: 

 0.021335 0.53 0.033273 0.83 0.053949 1.35 

Children 6-12 yrs: 

 0.014925 0.37 0.024651 0.62 0.033323 0.83 

Youth 13-19 yrs: 

 0.012125 0.30 0.019935 0.50 0.035854 0.90 

Adults 20-49 yrs: 

 0.013800 0.34 0.022787 0.57 0.041542 1.04 

Adults 50+ yrs: 

 0.012433 0.31 0.017753 0.44 0.028536 0.71 

Females 13-49 yrs: 

 0.013772 0.34 0.022480 0.56 0.038811 0.97
Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 

PC Code: 118602 

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ATTACHMENT 3 

U.S. Environmental Protection Agency Ver. 2.02 

DEEM-FCID ACUTE Analysis for IMAZASULFURON (1994-98 data) 

Residue file: imazasulfuron food.R98 Adjustment factor #2 NOT used. 

Analysis Date: 06-22-2010/09:56:16 Residue file dated: 06-22-2010/09:50:17/8 

Daily totals for food and foodform consumption used. 

Run Comment: "food only" 

=============================================================================== 

Summary calculations (per capita): 

 95th Percentile 99th Percentile 99.9th Percentile 

 Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- -------- 

U.S. Population: 

 0.000333 0.01 0.000711 0.02 0.001584 0.04 

All infants: 

 0.000367 0.01 0.000930 0.02 0.001578 0.04 

Children 1-2 yrs: 

 0.000896 0.02 0.001626 0.04 0.003325 0.08 

Children 3-5 yrs: 

 0.000739 0.02 0.001372 0.03 0.002636 0.07 

Children 6-12 yrs: 

 0.000494 0.01 0.000928 0.02 0.001723 0.04 

Youth 13-19 yrs: 

 0.000313 0.01 0.000624 0.02 0.001317 0.03 

Adults 20-49 yrs: 

 0.000277 0.01 0.000544 0.01 0.001020 0.03 

Adults 50+ yrs: 

 0.000236 0.01 0.000461 0.01 0.000793 0.02 

Females 13-49 yrs: 

 0.000259 0.01 0.000502 0.01 0.001030 0.03
Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 

PC Code: 118602 

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ATTACHMENT 4 

U.S. Environmental Protection Agency Ver. 2.00 

DEEM-FCID Chronic analysis for IMAZASULFURON 1994-98 data 

Residue file: C:\Documents and Settings\cwalls\My 

Documents\Cassi\HED\Imazasulfuron\imazasulfuron food and water.R98 

 Adjust. #2 NOT used 

Analysis Date 06-22-2010 Residue file dated: 06-22-2010/10:24:18/8 

Reference dose (RfD) = 0.75 mg/kg bw/day 

Comment:food and water 

-------------------------------------------------------------------------------- 

Food Crop Residue Adj.Factors 

Comment 

EPA Code Grp Food Name (ppm) 

 #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ --

----- 

08002700 8 Pepper, bell 0.040000 1.000 1.000 

08002701 8 Pepper, bell-babyfood 0.040000 1.000 1.000 

08002710 8 Pepper, bell, dried 0.040000 1.000 1.000 

08002711 8 Pepper, bell, dried-babyfood 0.040000 1.000 1.000 

08002720 8 Pepper, nonbell 0.040000 1.000 1.000 

08002721 8 Pepper, nonbell-babyfood 0.040000 1.000 1.000 

08002730 8 Pepper, nonbell, dried 0.040000 1.000 1.000 

15003230 15 Rice, white 0.040000 1.000 1.000 

15003231 15 Rice, white-babyfood 0.040000 1.000 1.000 

15003240 15 Rice, brown 0.040000 1.000 1.000 

15003241 15 Rice, brown-babyfood 0.040000 1.000 1.000 

15003250 15 Rice, flour 0.040000 1.000 1.000 

15003251 15 Rice, flour-babyfood 0.040000 1.000 1.000 

15003260 15 Rice, bran 0.040000 1.000 1.000 

15003261 15 Rice, bran-babyfood 0.040000 1.000 1.000 

08003740 8 Tomatillo 0.040000 1.000 1.000 

08003750 8 Tomato 0.040000 1.000 1.000 

08003751 8 Tomato-babyfood 0.040000 1.000 1.000 

08003760 8 Tomato, paste 0.040000 5.400 1.000 

08003761 8 Tomato, paste-babyfood 0.040000 5.400 1.000 

08003770 8 Tomato, puree 0.040000 3.300 1.000 

08003771 8 Tomato, puree-babyfood 0.040000 3.300 1.000 

08003780 8 Tomato, dried 0.040000 14.300 1.000 

08003781 8 Tomato, dried-babyfood 0.040000 14.300 1.000 

08003790 8 Tomato, juice 0.040000 1.500 1.000 

86010000 O Water, direct, all sources 0.278900 1.000 1.000 

86020000 O Water, indirect, all sources 0.278900 1.000 1.000 
Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 

PC Code: 118602 

______________________________________________________________________________________

Page 13 of 14 

ATTACHMENT 5 

U.S. Environmental Protection Agency Ver. 2.00 

DEEM-FCID Chronic analysis for IMAZASULFURON (1994-98 data) 

Residue file name: C:\Documents and Settings\cwalls\My 

Documents\Cassi\HED\Imazasulfuron\imazasulfuron food and water.R98 

 Adjustment factor #2 NOT used. 

Analysis Date 06-22-2010/10:25:31 Residue file dated: 06-22-2010/10:24:18/8 

Reference dose (RfD, Chronic) = .75 mg/kg bw/day 

COMMENT 1: food and water 

=============================================================================== 

 Total exposure by population subgroup 

------------------------------------------------------------------------------- 

 Total Exposure 

 ----------------------------------- 

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- --------------- 

U.S. Population (total) 0.005963 0.8% 

U.S. Population (spring season) 0.005909 0.8% 

U.S. Population (summer season) 0.006399 0.9% 

U.S. Population (autumn season) 0.005766 0.8% 

U.S. Population (winter season) 0.005769 0.8% 

Northeast region 0.005452 0.7% 

Midwest region 0.006025 0.8% 

Southern region 0.005666 0.8% 

Western region 0.006827 0.9% 

Hispanics 0.006783 0.9% 

Non-hispanic whites 0.005814 0.8% 

Non-hispanic blacks 0.005661 0.8% 

Non-hisp/non-white/non-black 0.007330 1.0% 

All infants (< 1 year) 0.019342 2.6% 

Nursing infants 0.007183 1.0% 

Non-nursing infants 0.023956 3.2% 

Children 1-6 yrs 0.008396 1.1% 

Children 7-12 yrs 0.005454 0.7% 

Females 13-19 (not preg or nursing) 0.004218 0.6% 

Females 20+ (not preg or nursing) 0.005929 0.8% 

Females 13-50 yrs 0.005762 0.8% 

Females 13+ (preg/not nursing) 0.005796 0.8% 

Females 13+ (nursing) 0.008209 1.1% 

Males 13-19 yrs 0.004414 0.6% 

Males 20+ yrs 0.005341 0.7% 

Seniors 55+ 0.005826 0.8% 

Children 1-2 yrs 0.008929 1.2% 

Children 3-5 yrs 0.008351 1.1% 

Children 6-12 yrs 0.005758 0.8% 

Youth 13-19 yrs 0.004335 0.6% 

Adults 20-49 yrs 0.005562 0.7% 

Adults 50+ yrs 0.005831 0.8% 

Females 13-49 yrs 0.005534 0.7% 

------------------------------------------------------------------------------- 
Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 

PC Code: 118602 

______________________________________________________________________________________

Page 14 of 14 

ATTACHMENT 6 

U.S. Environmental Protection Agency Ver. 2.00 

DEEM-FCID Chronic analysis for IMAZASULFURON (1994-98 data) 

Residue file name: C:\Documents and Settings\cwalls\My 

Documents\Cassi\HED\Imazasulfuron\imazasulfuron food.R98 

 Adjustment factor #2 NOT used. 

Analysis Date 06-22-2010/09:51:32 Residue file dated: 06-22-2010/09:50:17/8 

Reference dose (RfD, Chronic) = .75 mg/kg bw/day 

COMMENT 1: food only 

=============================================================================== 

 Total exposure by population subgroup 

------------------------------------------------------------------------------- 

 Total Exposure 

 ----------------------------------- 

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- --------------- 

U.S. Population (total) 0.000084 0.0% 

U.S. Population (spring season) 0.000082 0.0% 

U.S. Population (summer season) 0.000085 0.0% 

U.S. Population (autumn season) 0.000084 0.0% 

U.S. Population (winter season) 0.000086 0.0% 

Northeast region 0.000089 0.0% 

Midwest region 0.000082 0.0% 

Southern region 0.000078 0.0% 

Western region 0.000092 0.0% 

Hispanics 0.000110 0.0% 

Non-hispanic whites 0.000078 0.0% 

Non-hispanic blacks 0.000081 0.0% 

Non-hisp/non-white/non-black 0.000123 0.0% 

All infants (< 1 year) 0.000069 0.0% 

Nursing infants 0.000035 0.0% 

Non-nursing infants 0.000082 0.0% 

Children 1-6 yrs 0.000183 0.0% 

Children 7-12 yrs 0.000114 0.0% 

Females 13-19 (not preg or nursing) 0.000082 0.0% 

Females 20+ (not preg or nursing) 0.000061 0.0% 

Females 13-50 yrs 0.000075 0.0% 

Females 13+ (preg/not nursing) 0.000080 0.0% 

Females 13+ (nursing) 0.000064 0.0% 

Males 13-19 yrs 0.000089 0.0% 

Males 20+ yrs 0.000074 0.0% 

Seniors 55+ 0.000055 0.0% 

Children 1-2 yrs 0.000200 0.0% 

Children 3-5 yrs 0.000178 0.0% 

Children 6-12 yrs 0.000121 0.0% 

Youth 13-19 yrs 0.000085 0.0% 

Adults 20-49 yrs 0.000074 0.0% 

Adults 50+ yrs 0.000056 0.0% 

Females 13-49 yrs 0.000069 0.0% 

-------------------------------------------------------------------------------