1

Appendix B. Table of Generic Data Requirements and Studies Used to Make the 

Reregistration Decision for MGK 264 

GUIDE TO APPENDIX B

 Appendix B contains a listing of data requirements which support the 

reregistration for active ingredients within the case MGK 264 covered by this RED. In 

contains generic data requirements that apply nitrapyrin in all products, including data 

requirements for which a “typical formulation” is the test substance. 

The data table is organized in the following formats: 

1. Data requirement (Column 1). The data requirements are listed in the order in 

which they appear in 40 CFR 158. The reference numbers accompanying each 

test refer to the test protocols set in the Pesticide Assessment Guidance, which is 

available from the National Technical Information Service, 5285 Port Royal 

Road, Springfield, VA 22161. (703) 487-4650. 

2. Use Pattern (Column 2). This column indicates the use patterns for which the 

data requirements apply. The following letter designations are used for the given 

use patterns. 

A. Terrestrial food 

B. Terrestrial feed 

C. Terrestrial non-food 

D. Aquatic food 

E. Aquatic non-food outdoor 

F. Aquatic non-food industrial 

G. Aquatic non-food residential 

H. Greenhouse food 

I. Greenhouse non-food 

J. Forestry 

K. Residential 

L. Indoor food 

M. Indoor non-food 

N. Indoor medical 

O. Indoor residential 

3. Bibliographic Citation (Column 3). If the Agency has acceptable data in its files, this 

column lists the identifying number of each study. This normally is the Master Record 

Identification (MRID) number, but may be a “GS” number is no MRID number has been 

assigned. Refer to the Bibliography appendix for a complete citation of the study. 
2

Appendix B. Data Supporting Guideline Requirements for the Reregistration of MGK 264

New Guideline 

Number 

Old 

Guideline 

Number 

Description Use 

Patterns 

Citations 

PRODUCT CHEMISTRY 

830.1550 61-1 Product Identity and Composition All 40443701 

830.1600 61-2A Description of materials used to produce 

the product 

All 40195801 

830.1620 61-2B Description of production process Al 40195801 

830.1670 61-2B Formation of Impurities All 40359701 

830.1700 62-1 Preliminary Analysis All 40306301 

830.1750 62-0 Certification of Limits All 40306301 

830.1800 62-3 Analytical Method All 40306301 

830.6302 63-2 Color All 40528901 

830.6303 63-3 Physical State All 40528901 

830.6304 63-4 Odor All 40528901 

830.6313 63-13 Stability to normal and elevated 

temperatures, metals, and metal ions 

All 42082901 

830.7000 63-12 pH All 42082901 

830.7050 None UV/Visible Absorption All Data Gap 

830.7220 63-6 Boiling Point All 42082901 

830.7300 63-7 Density All 42082901 

830.7550 63-11 Partition coefficient, shake flask method All 42082901; 

42622501; 

42622502 

830.7840 63-8 Solubility All 42082901 

830.7950 63-9 Vapor Pressure All 42082901 

ENVIRONMENTAL TOXICITY

850.2100 71-1A Avian Acute Oral Toxicity – Quail 41687301 

850.2100 71-1A Avian Acute Oral Toxicity – Duck 41526102 

850.2200 71-2A Avian Dietary Toxicity – Quail 41687301 

850.2200 71-2B Avian Dietary Toxicity – Duck 41687302 

850.2300 71-4A Avian Reproduction – Quail Data Gap 

850.2300 71-4B Avian Reproduction – Duck Data Gap 

850.1075 72-1A Fish Toxicity Bluegill 41819701; 

41819702 

850.1075 72-1B Fish Toxicity Bluegill – TEP 41819701; 

41819702 

850.1075 72-1C Freshwater Fish Toxicity Rainbow Trout 41911501; 

41819702 

850.1075 72-1D Freshwater Fish Toxicity Rainbow Trout 

– TEP 

 41911501; 

41819702 

850.1010 72-2A Freshwater Invertebrate Toxicity 41526102 

850.1075 72-3A Estuarine/Marine Toxicity – Fish Data Gap 

850.1025 72-3B Estuarine/Marine Toxicity – Mollusk Data Gap 

850.1035 72-3C Estuarine/Marine Toxicity – Shrimp Data Gap 

850.1300 72-4 Freshwater Invertebrate Toxicity – 

Chronic 

 41526102 

850.3020 141-1 Honey Bee Acute Contact Data Gap 

TOXICOLOGY

870.1100 81-1 Acute Oral Toxicity - Rat 41752305, Data 

Gap

870.1200 81-2 Acute Dermal Toxicity – Rabbit/Rat 41860601 

870.1300 81-3 Acute Inhalation Toxicity – Rat Data Gap 
3

New Guideline 

Number 

Old 

Guideline 

Number 

Description Use 

Patterns 

Citations 

870.2400 81-4 Primary Eye Irritation - Rabbit 41860602 

870.2500 81-5 Primary Skin Irritation 92122005 

870.2600 81-6 Dermal Sensitization Data Gap

870.3100 82-1A Subchronic Oral Toxicity: 90-Day Study 

Rodent 

 42970601 

870.3150 82-1B Subchronic Oral Toxicity: 90-Day Study 

Non-rodent 

 42148101 

870.3200 82-2 21-Day Dermal – Rabbit/Rat Data Gap

870.3465 Subchronic Inhalation-rats 43309001 

870.3465 Subchronic Inhalation-rats 43309001 

870.4100 83-1B Chronic Feeding Toxicity – Non-rodent 42148102 

870.3700 83-3A Developmental Toxicity – Rat 41660302 

870.3700 83-3B Developmental Toxicity – Rabbit 40352301; 

45254201 

870.3800 83-4 2-Generation Reproduction – Rat 42155701 

870.4100 83-1A Chronic Feeding Toxicity Study – Rat 42148102 

870.4100 83-1B Chronic Feeding Toxicity Study - Nonrodent  42148102 

870.4200 83-2B Carcinogenicity Mice 42148102; 

42093802 

870.4300 83-5 Combined Chronic 

Toxicity/Carcinogenicity: Rats 

 43005301 

870.5100 84-2 Bacterial Reverse Gene Mutation 40399101 

870.5375 84-2B Cytogenetics 40399102 

870.5550 84-2 Unscheduled DNA Synthesis in 

Mammalian Cells in Culture 

 41703201 

870.7485 85-1 General Metabolism 42729701; 

42729702; 

42720703; 

42729704; 

42729705; 

42729706 

870.7600 85-3 Dermal Penetration and Absorption 42976701; 

42976702 

ENVIRONMENTAL FATE

835.2120 161-1 Hydrolysis 42222601; 

42355001 

835.2240 161-2 Photolysis 42222602; 

42355002 

835.2410 161-3 

Photodegradation - Water 

Photodegradation - Soil 42807501 

835.4100 162-1 Aerobic Soil Metabolism 43194501 

835.4200 162-2 Anaerobic Soil Metabolism 43194502 

835.4300 162-4 Aerobic Aquatic Metabolism Data Gap

835.1240 163-1 Leaching/Adsorption/Desorption 42622501 

850.1730 165-4 Bioaccumulation in Fish Data Gap

OCCUPATION/RESIDENTIAL EXPOSURE 

875.1700 Use and Usage Data Data Gap 

875.1400 234 Estimation of Inhalation Exposure, Indoor 

Sites 

Data Gap 

875.2400 133-3 Dermal (Passive Dosimetry) Exposure Data Gap 
4

New Guideline 

Number 

Old 

Guideline 

Number 

Description Use 

Patterns 

Citations 

RESIDUE CHEMISTRY

860.1500 171-4K Crop Field Trials 

 (commodities) A,B 42008601