UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF

PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

MEMORANDUM

DATE: 8/11/09

SUBJECT: Flumioxazin. Acute and Chronic Dietary (Food and Water) Exposure 

Assessments for the Petition Proposing Tolerances for Residues of 

Flumioxazin on Fish, Cucurbit Vegetables, Leaf Petioles, and Hops. 

Petition # 8F7438 & 8E7462 Decision Number: 402046

DP Number: 367978 MRID No.: NA

PC Code: 129034 Chemical Class: N-phenylpthalimide derivative herbicide

40 CFR 180. 568 CAS No.: 103361-09-7

Regulatory 

Action:

Section 3 Registration EPA Reg. No.: Clipper Herbicide (59639-161), 

ValorTM Herbicide (59639-99), and 

ChateauTM Herbicide (59639-119)

REVIEWER: W. Cutchin, Acting Senior Branch Scientist

Alternative Risk Integration and Assessment (ARIA) Team

Risk Integration Minor Use and Emergency Response Branch 

(RIMUERB)/Registration Division (RD; 7505P)

THROUGH: D. Rate, Biologist

D. Hrdy, Biologist

DESAC

Health Effects Division (HED; 7505P)

TO: W. Cutchin, Acting Senior Branch Scientist

ARIA Team

RIMUERB/RD (7505P)

and

J. Miller/ D. Rosenblatt

RIMUERB/RD (7505P)
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

PC Code: 129034

______________________________________________________________________________________

Page 2 of 15

Executive Summary

The purpose of this memorandum is to report the results of a dietary (food + drinking 

water) exposure analysis for the herbicide flumioxazin. In this analysis, the acute and 

chronic dietary exposure and risk estimates resulting from food and water intake were 

determined for the general U.S. population and various population subgroups.

Acute and chronic dietary risk assessments were conducted using the Dietary Exposure 

Evaluation Model (DEEM-FCIDTM, Version 2.03) which uses food consumption data 

from the U.S. Department of Agriculture’s Continuing Surveys of Food Intakes by 

Individuals (CSFII) from 1994-1996 and 1998. These analyses were performed to 

support a Section 3 requests (PP#s: 8F7438 & 8E7462) to establish tolerances for 

residues of flumioxazin on fish, cucurbit vegetables, leaf petioles, and hops.

In calculating dietary risk estimates, ARIA has compared both the acute populationadjusted dose (aPAD) and the chronic population-adjusted dose (cPAD) to the respective 

estimated dietary exposures. Typically, ARIA has concerns regarding dietary risk when 

the estimates exceed 100% of the aPAD or cPAD. With the conservative assumptions 

noted above, risk estimates associated with dietary exposure to flumioxazin are 

significantly below ARIA’s level of concern.

Both the acute and chronic exposure analyses were performed assuming tolerance-level 

residues of flumioxazin for all commodities with existing and ARIA recommended

tolerances, empirical processing factors obtained from processing studies (tomatoes) 

along with DEEM 7.81 default processing factors for the remaining processed 

commodities, 100% crop treated (CT) and an estimated drinking water concentration 

(EDWC) of 0.048 ppm for flumioxazin. 

Acute Dietary (Food + Drinking Water) Exposure Results and Characterization

There were no appropriate toxicological effects attributable to a single exposure (dose) 

for the general population or any other population subgroups except females 13-49 years 

old; therefore, these population subgroups were not included in this assessment. An 

acute dietary assessment was conducted only for the population subgroup females 13-49 

years old. For food and drinking water, the exposure to females 13-49 years old utilized 

9% of the aPAD at the 95th percentile of exposure distribution. The acute dietary risk 

assessment for flumioxazin shows that for all included commodities, the acute dietary

risk estimates are below ARIA’s level of concern (i.e. <100% aPAD). 

Chronic Dietary (Food + Drinking Water) Exposure Results and Characterization

A chronic dietary assessment was conducted for the general U.S. population and all 

population subgroups. For the general U.S. population the exposure for food and 

drinking water utilized 7% of the cPAD. The chronic dietary risk estimate for the highest 

reported exposed population subgroup, all infants (<1 year old), is 19% of the cPAD.
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

PC Code: 129034

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The chronic dietary risk assessment shows that for all included commodities, the chronic 

dietary risk estimates are below ARIA’s level of concern (i.e. <100% chronic population 

adjusted doses (cPAD). 

Cancer Exposure Results and Characterization

Flumioxazin was classified as “Not likely to be Carcinogenic to Humans” based on the

lack of carcinogenicity in a 2-year rat study, an 18-month mouse study, and a battery of 

mutagenic studies; therefore, no cancer assessment was performed.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For 

acute and chronic assessments, the risk is expressed as a percentage of a maximum 

acceptable dose (i.e., the dose which ARIA has concluded will result in no unreasonable 

adverse health effects). This dose is referred to as the population adjusted dose (PAD). 

The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, e.g.) divided by

the required uncertainty or safety factors. 

For acute and non-cancer chronic exposures, ARIA is concerned when estimated dietary

risk exceeds 100% of the PAD. ARIA is generally concerned when estimated cancer risk 

exceeds one in one million (i.e., the risk exceeds 1 x 10-6). References which discuss the 

acute and chronic risk assessments in more detail are available on the EPA/pesticides 

web site: “Available Information on Assessing Exposure from Pesticides, A User’s 

Guide,” 6/21/2000, web link: http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day12/6061.pdf ; or see SOP 99.6 (8/20/99).

The most recent dietary risk assessment for flumioxazin was conducted by B. Hanson

(PP#7F7243, DP#: 342414, 3/5/08).

II. Residue Information

Tolerances: Tolerances are currently established for residues of the herbicide 

flumioxazin in/on various plant commodities, at levels ranging from 0.02 to 8.0 ppm (as 

listed in e-CFR 40 §180.568[a], Updated June 1, 2009).

Residue of Concern: The residue of concern for both the tolerance expression and risk 

assessment in plants is flumioxazin per se. The residue of concern for both the tolerance 

expression and risk assessment in fish is flumioxazin and its metabolites APF (3-oxo-4-

prop-2ynyl-6-amino-7-fluoro-3,4-dihydro-1,4-benzoxazin) and 482-HA (N-(7-fluoro-3,4-

dihdyro-3-oxo-4-prop-2-ynyl-2H-1,4-benzoxazin-6-yl)cyclohex-1-ene-1-carboxamide-2-

carboxylic acid), each expressed as parent equivalents.

Residue Data Used for Dietary Assessments: Previously, residue data from field trials 

conducted to support the existing registrations show that, generally, residues of 

flumioxazin are low, and that residues do not concentrate into processed products; 
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

PC Code: 129034

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therefore, use of default processing factors in the analysis is considered conservative and 

will overestimate dietary exposure.

Current and ARIA recommended tolerance-level residues were used for all raw 

agricultural commodities (RACs). DEEM 7.81 processing factors were used for all 

processed commodities, with the exception of tomato which used the empirical 

processing factor of one. A tomato processing factor of 1 is based on an exaggerated 

(~5x) crop field trial study in which no residues were recovered; therefore, a processing 

study is not required (47005106.der.com, D. Rate, 6/19/07). 100%CT was assumed for 

all commodities in this assessment. 

As part of the current petition, ARIA recommends establishing tolerances:

Fish, fresh water...............................................................................1.5 ppm

Cucurbit vegetables group 9 ............................................................0.03 ppm

Leaf petioles subgroup 4B ...............................................................0.02 ppm

Hops, dried cones.............................................................................0.05 ppm

Because the aquatic applications of flumioxazin are prohibited to flowing water, intertidal 

or estuarine areas and to water used for crawfish farming, residue data and tolerances are 

not required for shellfish or saltwater fishes.

III. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by EFED

in the following memorandum: “Drinking Water Assessment for: (1) IR-4 Registration 

for Flumioxazin to be used on Asparagus, Dry Bean, Bushberry Subgroup 13B, Fruiting 

Vegetable Subgroup 8, Melon Subgroup 9A, Okra and Tree Nut Subgroup 14; and (2) 

Section 3 Registration for Use on Field Corn and Alfalfa (DP#: D336195, 342249, 

331732; L. Liu; 9/25/07) and incorporated directly into this dietary assessment. Water 

residues were incorporated in the DEEM-FCID into the food categories “water, direct, all 

sources” and “water, indirect, all sources.” 

The hydrolysis study for flumioxazin indicates that flumioxazin forms the metabolite 

482-HA, which can further hydrolyze to the metabolites APF and THPA. The rates of 

the two hydrolytic reactions are very pH dependent, but flumioxazin (parent compound) 

is not very stable at any likely environmental pH. Data also indicates that THPA and 

APF are likely to be very mobile. Although THPA can comprise a major portion of the 

total residue in water, it does not possess the phenyl ring and is thus considered 

significantly less toxic than parent, APF, and 482-HA. Thus, THPA has not been 

included in the residue of concern for drinking water. Therefore, parent flumioxazin and 

the metabolites 482-HA and APF are the residues of concern in drinking water. The 

EDWCs for flumioxazin residues (used in both the acute and chronic dietary analyses) 

was 0.048 ppm, the concentration in groundwater as estimated by the Screening 

Concentration In GroundWater (SCI-GROW) model. SCI-GROW is an empirical model 

for predicting pesticide levels in groundwater; the value from SCI-GROW is considered 
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

PC Code: 129034

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an upper bound concentration estimate, and thus conservative. In order to be 

conservative with the estimates, the groundwater EDWC (0.048 ppm), greater than the 

surface water EDWC (0.034 ppm), was used in both dietary analyses

Table 1 summarizes the drinking water concentrations provided by EFED. The model 

and its description are available at the EPA internet site:

http://www.epa.gov/oppefed1/models/water/.

Table 1. EDWCs for Flumioxazin and its Degradates in Surface Water and Groundwater 

at pH 7.1

Compound Average 56-Day 

Conc. in Surface 

Water

Peak Conc. in 

Surface Water

Conc. in 

Groundwater

Flumioxazin negligible 1.03 ppb negligible

482-HA 4.84 ppb 6.87 ppb 45.27 ppb

APF 12.85 ppb 26.46 ppb 2.66 ppb

THPA 19.50 ppb 27.67 ppb 182.28 ppb

1 Total EDWC = Flumioxazin + 482-HA + APF

IV. DEEM-FCIDTM Program and Consumption Information

Flumioxazin acute and chronic dietary exposure assessments were conducted using the 

Dietary Exposure Evaluation Model software with the Food Commodity Intake Database 

(DEEM-FCIDTM, Version 2.03), which incorporates consumption data from USDA’s 

Continuing Surveys of Food Intakes by Individuals (CSFII), 1994-1996 and 1998. The 

1994-96, 98 data are based on the reported consumption of more than 20,000 individuals 

over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked 

to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation 

files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, 

consumption data are averaged for the entire U.S. population and within population 

subgroups, but for acute exposure assessment are retained as individual consumption 

events. Based on analysis of the 1994-96, 98 CSFII consumption data, which took into 

account dietary patterns and survey respondents, HED concluded that it is most 

appropriate to report risk for the following population subgroups: the general U.S. 

population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-

19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or 

food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied 

by the average daily consumption estimate for that food/food form to produce a residue 

intake estimate. The resulting residue intake estimate for each food/food form is summed 

with the residue intake estimates for all other food/food forms on the commodity residue 

list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg 
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

PC Code: 129034

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body weight/day and as a percent of the cPAD. This procedure is performed for each 

population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on 

an individual-by-individual basis. The reported consumption amounts of each food item 

can be multiplied by a residue point estimate and summed to obtain a total daily pesticide 

exposure for a deterministic exposure assessment, or “matched” in multiple random 

pairings with residue values and then summed in a probabilistic assessment. The 

resulting distribution of exposures is expressed as a percentage of the aPAD on both a 

user (i.e., only those who reported eating relevant commodities/food forms) and a percapita (i.e., those who reported eating the relevant commodities as well as those who did 

not) basis. In accordance with HED policy, per capita exposure and risk are reported for 

all tiers of analysis. However, for tiers 1 and 2, any significant differences in user vs. per 

capita exposure and risk are specifically identified and noted in the risk assessment.

V. Toxicological Information

The findings of the flumioxazin risk assessment team, relative to dietary exposure, are 

summarized in Table 2 (below). In accordance with the EPA Draft Guidelines for 

Carcinogen Risk Assessment (July, 1999), flumioxazin was classified as “not likely to be 

carcinogenic to humans.” 

Table 2. Summary of Toxicological Doses and Endpoints for Use in Human Health Dietary

Risk Assessment for Flumioxazin. 

Exposure/

Scenario

Point of 

Departure

Uncertainty/

FQPA Safety 

Factors

RfD, PAD, 

Level of 

Concern 

Study and Toxicological 

Effects

Acute Dietary 

(General 

Population, 

including Infants 

and Children)

No endpoint attributable to a single dose (exposure) was identified in the available 

studies, including the developmental toxicity studies in rats and rabbits. 

Acute Dietary

(Females 13-49 

years of age)

NOAEL = 3 

mg/kg/day

UFA= 10x

UFH= 10x

FQPA SF = 1X

Total UF = 100X

Acute RfD =

NOAEL  UF = 

0.03 mg/kg/day

aPAD = 0.03 

mg/kg/day

Oral developmental and 

supplemental prenatal studies 

in the rat. 

LOAEL = 10 mg/kg/day 

based on cardiovascular 

effects (especially ventricular 

septal defects in fetuses).

Chronic Dietary 

(All Populations)

NOAEL = 2 

mg/kg/day

UFA= 10x

UFH= 10x

FQPA SF = 1X

Chronic RfD 

FQPA SF = 

0.02 mg/kg/day

cPAD = 0.02 

2-year chronic/carcinogenicity 

study in the rat. 

LOAEL = 18 mg/kg/day 

based on increased chronic 

nephropathy in males, and 

decreased hematological 
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

PC Code: 129034

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Total UF = 100X mg/kg/day parameters in females (Hgb, 

MCV, MCH, and MCHC). 

Cancer (oral, dermal, inhalation) Classification: “Not likely to be Carcinogenic to Humans” based on 

the lack of carcinogenicity in a 2-year rat study, an 18-month mouse 

study, and a battery of mutagenic studies. 

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA = extrapolation from animal to human (intraspecies). UFH = potential variation in sensitivity 

among members of the human population (interspecies). UFL = use of a LOAEL to extrapolate a NOAEL. UFS = use 

of a short-term study for long-term risk assessment. UFDB = to account for the absence of key data (i.e., lack of a 

critical study). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = 

reference dose. LOC = level of concern. N/A = not applicable.

VI. Results/Discussion 

As stated above, for acute or chronic dietary assessments, ARIA is concerned when 

dietary risk exceeds 100% of the PAD. The DEEM-FCID analyses estimate the dietary

exposure of the US population and various population subgroups. The results reported in 

Table 3 (below) are for the general US population (total), all infants <1, children 1-2, 

children 3-5, children 6-12, youths 13-19, females 13-49, adults 20-49, and adults 50+ for 

chronic exposure and females 13-49 for acute exposure. 

Results of Acute Dietary Exposure Analysis

Flumioxazin acute dietary (food + water) exposure estimates using the DEEM-FCIDTM 

software are below ARIA’s level of concern for females 13-49. The acute dietary

exposure for the females, 13-49 years old, utilized 9% of the aPAD.

Results of Chronic Dietary Exposure Analysis

Flumioxazin chronic dietary (food + water) exposure estimates using the DEEM-FCIDTM 

software are below ARIA’s level of concern for the U.S. population and each of the 

population subgroups. Chronic dietary exposure utilized 7% of the cPAD for the U.S. 

population. The chronic dietary exposure for the highest reported exposed population 

subgroup, all infants (<1 year old), was 19% of the cPAD.

The results of the acute and chronic dietary exposure analyses are reported in the 

Summary Table (Table 3, below).

TABLE 3. Summary of Dietary Exposure and Risk for Flumioxazin. 

Population Subgroup1 DEEM Acute Dietary Analysis,

95th Percentile

DEEM Chronic Dietary Analysis
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

PC Code: 129034

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aPAD 

(mg/kg)

Exposure 

(mg/kg/day)

% aPAD cPAD 

(mg/kg/day)

Exposure 

(mg/kg/day)

% cPAD

General U.S. Population

NA 2

0.02 0.001307 7

All Infants (< 1 year old) 0.02 0.003761 19

Children 1-2 years old 0.02 0.002289 11

Children 3-5 years old 0.02 0.002120 11

Children 6-12 years old 0.02 0.001433 7

Youth 13-19 years old 0.02 0.000980 5

Adults 20-49 years old 0.02 0.001165 6

Adults 50+ years old 0.02 0.001225 6

Females 13-49 years old 0.03 0.002734 9 0.02 0.001165 6

1 Values for the population with the highest risk for each type of risk assessment are bolded. 

2 NA = Not Applicable; no acute dietary endpoint was identified for these population subgroups

VII. Characterization of Inputs/Outputs

The assumptions made in this assessment are conservative, and are very likely to result in 

exposure and risk values that considerably overestimate actual dietary exposure to 

flumioxazin. Although not needed at this time, the analyses could be further refined 

through the use of average residues based on field trial data, percent crop treated data 

and/or preparation/cooking factors. Since risk estimates are below ARIA’s level of 

concern, a more highly refined analysis is not needed at this time.

VIII.Conclusions

Based on conservative assumptions, dietary risk estimates for flumioxazin do not exceed 

ARIA’s level of concern for the general U.S. population, nor did any of the population 

subgroups, including those comprised of infants and children. For the acute analysis, 

there were no differences between user vs. per capita exposure and risk.

IX. List of Attachments

Attachment 1: Food plus Water Residue Input File

Attachment 2: Acute Results File

Attachment 3: Chronic Results File

Attachment 4: Chemical Structure of Flumioxazin and metabolites (482-HA and APF) 

used in the EDWCs.
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

PC Code: 129034

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Attachment 1: Food plus Water Residue Input File

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for FLUMIOXAZIN 1994-98 data

Residue file: G:\129034c.r98 Adjust. #2 NOT used

Analysis Date 06-04-2009 Residue file dated: 06-04-2009/10:40:15/8

Reference dose (RfD) = 0.02 mg/kg bw/day

--------------------------------------------------------------------------------

Food Crop Residue Adj.Factors Comment

EPA Code Grp Food Name (ppm) 

 #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

14000030 14 Almond 0.020000 1.000 1.000 

14000031 14 Almond-babyfood 0.020000 1.000 1.000 

14000040 14 Almond, oil 0.020000 1.000 1.000 

14000041 14 Almond, oil-babyfood 0.020000 1.000 1.000 

11000070 11 Apple, fruit with peel 0.020000 1.000 1.000 

11000080 11 Apple, peeled fruit 0.020000 1.000 1.000 

11000081 11 Apple, peeled fruit-babyfood 0.020000 1.000 1.000 

11000090 11 Apple, dried 0.020000 8.000 1.000 

11000091 11 Apple, dried-babyfood 0.020000 8.000 1.000 

11000100 11 Apple, juice 0.020000 1.300 1.000 

11000101 11 Apple, juice-babyfood 0.020000 1.300 1.000 

11000110 11 Apple, sauce 0.020000 1.000 1.000 

11000111 11 Apple, sauce-babyfood 0.020000 1.000 1.000 

12000120 12 Apricot 0.020000 1.000 1.000 

12000121 12 Apricot-babyfood 0.020000 1.000 1.000 

12000130 12 Apricot, dried 0.020000 6.000 1.000 

12000140 12 Apricot, juice 0.020000 1.000 1.000 

12000141 12 Apricot, juice-babyfood 0.020000 1.000 1.000 

01030150 1CD Arrowroot, flour 0.020000 1.000 1.000 

01030151 1CD Arrowroot, flour-babyfood 0.020000 1.000 1.000 

01030170 1CD Artichoke, Jerusalem 0.020000 1.000 1.000 

95000190 O Asparagus 0.020000 1.000 1.000 

09020210 9B Balsam pear 0.030000 1.000 1.000 

06030300 6C Bean, black, seed 0.050000 1.000 1.000 

06030320 6C Bean, broad, seed 0.050000 1.000 1.000 

06030340 6C Bean, cowpea, seed 0.050000 1.000 1.000 

06030350 6C Bean, great northern, seed 0.050000 1.000 1.000 

06030360 6C Bean, kidney, seed 0.050000 1.000 1.000 

06030380 6C Bean, lima, seed 0.050000 1.000 1.000 

06030390 6C Bean, mung, seed 0.050000 1.000 1.000 

06030400 6C Bean, navy, seed 0.050000 1.000 1.000 

06030410 6C Bean, pink, seed 0.050000 1.000 1.000 

06030420 6C Bean, pinto, seed 0.050000 1.000 1.000 

13020570 13B Blueberry 0.020000 1.000 1.000 

13020571 13B Blueberry-babyfood 0.020000 1.000 1.000 

14000590 14 Brazil nut 0.020000 1.000 1.000 

14000680 14 Butternut 0.020000 1.000 1.000 

09010750 9A Cantaloupe 0.030000 1.000 1.000 

04020760 4B Cardoon 0.020000 1.000 1.000 

09010800 9A Casaba 0.030000 1.000 1.000 

14000810 14 Cashew 0.020000 1.000 1.000 

01030820 1CD Cassava 0.020000 1.000 1.000 

01030821 1CD Cassava-babyfood 0.020000 1.000 1.000 

04020850 4B Celery 0.020000 1.000 1.000 

04020851 4B Celery-babyfood 0.020000 1.000 1.000 

04020860 4B Celery, juice 0.020000 1.000 1.000 

04020870 4B Celtuce 0.020000 1.000 1.000 

09020880 9B Chayote, fruit 0.030000 1.000 1.000 

12000900 12 Cherry 0.020000 1.000 1.000 

12000901 12 Cherry-babyfood 0.020000 1.000 1.000 

12000910 12 Cherry, juice 0.020000 1.500 1.000 

12000911 12 Cherry, juice-babyfood 0.020000 1.500 1.000 

14000920 14 Chestnut 0.020000 1.000 1.000 

09021020 9B Chinese waxgourd 0.030000 1.000 1.000 

15001200 15 Corn, field, flour 0.020000 1.000 1.000 
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15001201 15 Corn, field, flour-babyfood 0.020000 1.000 1.000 

15001210 15 Corn, field, meal 0.020000 1.000 1.000 

15001211 15 Corn, field, meal-babyfood 0.020000 1.000 1.000 

15001220 15 Corn, field, bran 0.020000 1.000 1.000 

15001230 15 Corn, field, starch 0.020000 1.000 1.000 

15001231 15 Corn, field, starch-babyfood 0.020000 1.000 1.000 

15001240 15 Corn, field, syrup 0.020000 1.500 1.000 

15001241 15 Corn, field, syrup-babyfood 0.020000 1.500 1.000 

15001250 15 Corn, field, oil 0.020000 1.000 1.000 

15001251 15 Corn, field, oil-babyfood 0.020000 1.000 1.000 

95001280 O Cottonseed, oil 0.020000 1.000 1.000 

95001281 O Cottonseed, oil-babyfood 0.020000 1.000 1.000 

11001290 11 Crabapple 0.020000 1.000 1.000 

95001300 O Cranberry 0.020000 1.000 1.000 

95001301 O Cranberry-babyfood 0.020000 1.000 1.000 

95001310 O Cranberry, dried 0.020000 1.000 1.000 

95001320 O Cranberry, juice 0.020000 1.100 1.000 

95001321 O Cranberry, juice-babyfood 0.020000 1.100 1.000 

09021350 9B Cucumber 0.030000 1.000 1.000 

13021360 13B Currant 0.020000 1.000 1.000 

13021370 13B Currant, dried 0.020000 1.000 1.000 

01031390 1CD Dasheen, corm 0.020000 1.000 1.000 

08001480 8 Eggplant 0.020000 1.000 1.000 

13021490 13B Elderberry 0.020000 1.000 1.000 

04021520 4B Fennel, Florence 0.020000 1.000 1.000 

14001550 14 Filbert 0.020000 1.000 1.000 

14001560 14 Filbert, oil 0.020000 1.000 1.000 

80001570 F Fish-freshwater finfish 1.500000 1.000 1.000 

80001580 F Fish-freshwater finfish, farm ra 1.500000 1.000 1.000 

03001640 3 Garlic 0.020000 1.000 1.000 

03001650 3 Garlic, dried 0.020000 1.000 1.000 

03001651 3 Garlic, dried-babyfood 0.020000 1.000 1.000 

01031660 1CD Ginger 0.020000 1.000 1.000 

01031661 1CD Ginger-babyfood 0.020000 1.000 1.000 

01031670 1CD Ginger, dried 0.020000 1.000 1.000 

13021740 13B Gooseberry 0.020000 1.000 1.000 

95001750 O Grape 0.020000 1.000 1.000 

95001760 O Grape, juice 0.020000 1.200 1.000 

95001761 O Grape, juice-babyfood 0.020000 1.200 1.000 

95001770 O Grape, leaves 0.020000 1.000 1.000 

95001780 O Grape, raisin 0.020000 4.300 1.000 

95001790 O Grape, wine and sherry 0.020000 1.000 1.000 

14001850 14 Hickory nut 0.020000 1.000 1.000 

09011870 9A Honeydew melon 0.030000 1.000 1.000 

95001880 O Hop 0.050000 1.000 1.000 

13021910 13B Huckleberry 0.020000 1.000 1.000 

11002100 11 Loquat 0.020000 1.000 1.000 

14002130 14 Macadamia nut 0.020000 1.000 1.000 

12002300 12 Nectarine 0.020000 1.000 1.000 

08002340 8 Okra 0.020000 1.000 1.000 

03002370 3 Onion, dry bulb 0.020000 1.000 1.000 

03002371 3 Onion, dry bulb-babyfood 0.020000 1.000 1.000 

03002380 3 Onion, dry bulb, dried 0.020000 9.000 1.000 

03002381 3 Onion, dry bulb, dried-babyfood 0.020000 9.000 1.000 

03002390 3 Onion, green 0.020000 1.000 1.000 

12002600 12 Peach 0.020000 1.000 1.000 

12002601 12 Peach-babyfood 0.020000 1.000 1.000 

12002610 12 Peach, dried 0.020000 7.000 1.000 

12002611 12 Peach, dried-babyfood 0.020000 7.000 1.000 

12002620 12 Peach, juice 0.020000 1.000 1.000 

12002621 12 Peach, juice-babyfood 0.020000 1.000 1.000 

95002630 O Peanut 0.020000 1.000 1.000 

95002640 O Peanut, butter 0.020000 1.890 1.000 

95002650 O Peanut, oil 0.020000 1.000 1.000 

11002660 11 Pear 0.020000 1.000 1.000 

11002661 11 Pear-babyfood 0.020000 1.000 1.000 

11002670 11 Pear, dried 0.020000 6.250 1.000 

11002680 11 Pear, juice 0.020000 1.000 1.000 

11002681 11 Pear, juice-babyfood 0.020000 1.000 1.000 

14002690 14 Pecan 0.020000 1.000 1.000 
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

PC Code: 129034

______________________________________________________________________________________

Page 11 of 15

08002700 8 Pepper, bell 0.020000 1.000 1.000 

08002701 8 Pepper, bell-babyfood 0.020000 1.000 1.000 

08002710 8 Pepper, bell, dried 0.020000 1.000 1.000 

08002711 8 Pepper, bell, dried-babyfood 0.020000 1.000 1.000 

08002720 8 Pepper, nonbell 0.020000 1.000 1.000 

08002721 8 Pepper, nonbell-babyfood 0.020000 1.000 1.000 

08002730 8 Pepper, nonbell, dried 0.020000 1.000 1.000 

95002750 O Peppermint 0.040000 1.000 1.000 

14002820 14 Pistachio 0.020000 1.000 1.000 

12002850 12 Plum 0.020000 1.000 1.000 

12002851 12 Plum-babyfood 0.020000 1.000 1.000 

12002860 12 Plum, prune, fresh 0.020000 1.000 1.000 

12002861 12 Plum, prune, fresh-babyfood 0.020000 1.000 1.000 

12002870 12 Plum, prune, dried 0.020000 5.000 1.000 

12002871 12 Plum, prune, dried-babyfood 0.020000 5.000 1.000 

12002880 12 Plum, prune, juice 0.020000 1.400 1.000 

12002881 12 Plum, prune, juice-babyfood 0.020000 1.400 1.000 

01032960 1C Potato, chips 0.020000 1.000 1.000 

01032970 1C Potato, dry (granules/ flakes) 0.020000 6.500 1.000 

01032971 1C Potato, dry (granules/ flakes)-b 0.020000 6.500 1.000 

01032980 1C Potato, flour 0.020000 6.500 1.000 

01032981 1C Potato, flour-babyfood 0.020000 6.500 1.000 

01032990 1C Potato, tuber, w/peel 0.020000 1.000 1.000 

01032991 1C Potato, tuber, w/peel-babyfood 0.020000 1.000 1.000 

01033000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 

01033001 1C Potato, tuber, w/o peel-babyfood 0.020000 1.000 1.000 

09023080 9B Pumpkin 0.030000 1.000 1.000 

09023090 9B Pumpkin, seed 0.030000 1.000 1.000 

11003100 11 Quince 0.020000 1.000 1.000 

04023220 4B Rhubarb 0.020000 1.000 1.000 

03003380 3 Shallot 0.020000 1.000 1.000 

06003470 6 Soybean, seed 0.020000 1.000 1.000 

06003480 6 Soybean, flour 0.020000 1.000 1.000 

06003481 6 Soybean, flour-babyfood 0.020000 1.000 1.000 

06003490 6 Soybean, soy milk 0.020000 1.000 1.000 

06003491 6 Soybean, soy milk-babyfood or in 0.020000 1.000 1.000 

06003500 6 Soybean, oil 0.020000 1.000 1.000 

06003501 6 Soybean, oil-babyfood 0.020000 1.000 1.000 

95003520 O Spearmint 0.040000 1.000 1.000 

09023560 9B Squash, summer 0.030000 1.000 1.000 

09023561 9B Squash, summer-babyfood 0.030000 1.000 1.000 

09023570 9B Squash, winter 0.030000 1.000 1.000 

09023571 9B Squash, winter-babyfood 0.030000 1.000 1.000 

95003590 O Strawberry 0.070000 1.000 1.000 

95003591 O Strawberry-babyfood 0.070000 1.000 1.000 

95003600 O Strawberry, juice 0.070000 1.000 1.000 

95003601 O Strawberry, juice-babyfood 0.070000 1.000 1.000 

95003620 O Sugarcane, sugar 0.200000 1.000 1.000 

95003621 O Sugarcane, sugar-babyfood 0.200000 1.000 1.000 

95003630 O Sugarcane, molasses 0.200000 1.000 1.000 

95003631 O Sugarcane, molasses-babyfood 0.200000 1.000 1.000 

01033660 1CD Sweet potato 0.020000 1.000 1.000 

01033661 1CD Sweet potato-babyfood 0.020000 1.000 1.000 

04023670 4B Swiss chard 0.020000 1.000 1.000 

01033710 1CD Tanier, corm 0.020000 1.000 1.000 

08003740 8 Tomatillo 0.020000 1.000 1.000 

08003750 8 Tomato 0.020000 1.000 1.000 

08003751 8 Tomato-babyfood 0.020000 1.000 1.000 

08003760 8 Tomato, paste 0.020000 1.000 1.000 

08003761 8 Tomato, paste-babyfood 0.020000 1.000 1.000 

08003770 8 Tomato, puree 0.020000 1.000 1.000 

08003771 8 Tomato, puree-babyfood 0.020000 1.000 1.000 

08003780 8 Tomato, dried 0.020000 1.000 1.000 

08003781 8 Tomato, dried-babyfood 0.020000 1.000 1.000 

08003790 8 Tomato, juice 0.020000 1.000 1.000 

01033870 1CD Turmeric 0.020000 1.000 1.000 

14003910 14 Walnut 0.020000 1.000 1.000 

86010000 O Water, direct, all sources 0.048000 1.000 1.000 

86020000 O Water, indirect, all sources 0.048000 1.000 1.000 

09013990 9A Watermelon 0.030000 1.000 1.000 
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

PC Code: 129034

______________________________________________________________________________________

Page 12 of 15

09014000 9A Watermelon, juice 0.030000 1.000 1.000 

01034060 1CD Yam, true 0.020000 1.000 1.000 

01034070 1CD Yam bean 0.020000 1.000 1.000 
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

PC Code: 129034

______________________________________________________________________________________

Page 13 of 15

Attachment 2: Acute Results File

U.S. Environmental Protection Agency Ver. 2.02

DEEM-FCID ACUTE Analysis for FLUMIOXAZIN (1994-98 data)

Residue file: 129034c.r98 Adjustment factor #2 NOT used.

Analysis Date: 06-04-2009/11:46:48 Residue file dated: 06-04-2009/10:40:15/8

Daily totals for food and foodform consumption used.

Run Comment: ""

===============================================================================

Summary calculations (per capita):

 95th Percentile 99th Percentile 99.9th Percentile

 Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Females 13-49 yrs:

 0.002734 9.11 0.004778 15.93 0.009800 32.67 

U.S. Environmental Protection Agency Ver. 2.02

DEEM-FCID ACUTE Analysis for FLUMIOXAZIN (1994-98 data)

Residue file: 129034c.r98 Adjustment factor #2 NOT used.

Analysis Date: 06-04-2009/11:46:48 Residue file dated: 06-04-2009/10:40:15/8

Acute Reference Dose (aRfD) = 0.030000 mg/kg body-wt/day

Daily totals for food and foodform consumption used.

Run Comment: ""

===============================================================================

Females 13-49 yrs Daily Exposure Analysis /a

----------------- (mg/kg body-weight/day) 

 per Capita per User 

 ----------- -----------

 Mean 0.001165 0.001165

 Standard Deviation 0.000950 0.000950

 Standard Error of mean 0.000012 0.000012

 Percent of aRfD 3.88 3.88

 Percent of Person-Days that are User-Days = 99.99%
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

PC Code: 129034

______________________________________________________________________________________

Page 14 of 15

Attachment 3: Chronic Results File

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for FLUMIOXAZIN (1994-98 data)

Residue file name: G:\129034c.r98 Adjustment factor #2 NOT used.

Analysis Date 06-04-2009/11:44:53 Residue file dated: 06-04-2009/10:40:15/8

Reference dose (RfD, Chronic) = .02 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ---------------

U.S. Population (total) 0.001307 6.5%

U.S. Population (spring season) 0.001306 6.5%

U.S. Population (summer season) 0.001393 7.0%

U.S. Population (autumn season) 0.001271 6.4%

U.S. Population (winter season) 0.001255 6.3%

Northeast region 0.001194 6.0%

Midwest region 0.001322 6.6%

Southern region 0.001251 6.3%

Western region 0.001481 7.4%

Hispanics 0.001452 7.3%

Non-hispanic whites 0.001271 6.4%

Non-hispanic blacks 0.001280 6.4%

Non-hisp/non-white/non-black 0.001631 8.2%

All infants (< 1 year) 0.003761 18.8%

Nursing infants 0.001448 7.2%

Non-nursing infants 0.004639 23.2%

Children 1-6 yrs 0.002130 10.6%

Children 7-12 yrs 0.001361 6.8%

Females 13-19 (not preg or nursing) 0.000944 4.7%

Females 20+ (not preg or nursing) 0.001229 6.1%

Females 13-50 yrs 0.001216 6.1%

Females 13+ (preg/not nursing) 0.001211 6.1%

Females 13+ (nursing) 0.001684 8.4%

Males 13-19 yrs 0.001010 5.0%

Males 20+ yrs 0.001135 5.7%

Seniors 55+ 0.001229 6.1%

Children 1-2 yrs 0.002289 11.4%

Children 3-5 yrs 0.002120 10.6%

Children 6-12 yrs 0.001433 7.2%

Youth 13-19 yrs 0.000980 4.9%

Adults 20-49 yrs 0.001165 5.8%

Adults 50+ yrs 0.001225 6.1%

Females 13-49 yrs 0.001165 5.8%

-------------------------------------------------------------------------------
Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

PC Code: 129034

______________________________________________________________________________________

Page 15 of 15

Attachment 4: Chemical Structure of Flumioxazin and metabolites (482-HA and 

APF) used in the EDWCs.

Chemical Name Structure

Flumioxazin

2-[7-fluoro-3,4-dihydro-3-oxo-4-(2-

propynyl)-2H-1,4-benzoxazin-6-yl]-

4,5,6,7-tetrahydro-1H-isoindole1,3(2H)-dione

O N

N O

O

O

F

C CH

482-HA

N-[7-fluoro-3-oxo-4-(2-propynyl)-

2H-1,4-benzoxazin-6-yl]-3,4,5,6-

tetrahydrophthalamic acid HO

O

O

N

H

O

N

O

F

C CH

APF

6-amino-7-fluoro-4-(2-propenyl)-

2H-1,4-benzoxazin-3(4H)-one O

N

O

F

NH2

C CH