### UNITED STA T ES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES 

### MEMORANDUM DATE: 8/11 /09 SUBJECT: Flumioxazin . Acute and Chronic Dietary (Food and Water) Exposure Assessments for the P etition Propos ing Tolerance s for Residues of Flumioxazin on Fish, Cucurbit Vegetables, Leaf Petioles, and Hops

. Petition # 8F7438 & 8E7462 Decision Number: 402046 DP Number: 367978 MRID No.: NA PC Code: 129034 Chemical Class: N - phenylpthalimide derivative herbicide 40 CFR 180. 568 CAS No.: 103361 - 09 - 7 Regulatory Action: Section 3 Registration EPA Reg . No. : Clipper Herbicide ( 59639 - 161 ), ValorTM Herbicide (59639 - 99), and ChateauTM Herbicide (59639 - 119) 

### REVIEWER: W . Cutchin, Acting Senior Branch Scientist

Alternative Risk Integration and Assessment (ARIA ) Team Risk Integration Minor Use and Emergency Response Branch (RIMUERB) /Registration Division (RD ; 7505P) THROUGH: D . Rate , Biologist

D . Hrdy , Biologist DESAC Health Effects Division (HED; 7505P) TO: W . Cutchin, Acting Senior Branch Scientist

ARIA Team RIMUERB /RD (7505P) and J. Miller / D. Rosenblatt RIMUERB/RD (7505P)Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

PC Code: 129034

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### Executive Summary The purpose of this memorandum is to report the r esults of a dietary (food + drinking water) e xposure anal ys is for the herbicide flumioxazin . Inthis anal ys is, the acute and chronic dietary

exposure and risk estimates resulting from food and water intake were determined for the general U.S. population and various population subgroups . A cute and c hronic dietary risk assessment s were conducted using the Dietary Exposure Evaluation Model (DEEM - FCI DTM, Version 2.03) which uses food consumption data from the U.S. Department of Agriculture’s Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994 - 1996 and 1998. These anal ys es were performed to support a Section 3 request s ( PP# s: 8F7438 & 8 E7462 ) to establish tolerances for residues of flumioxazin on fish, cucurbit vegetables, leaf petioles, and hops . In calculating dietary

risk estimates, ARIA has compared both the acute population adjusted dose (aPAD) and the chronic population - adjusted d ose (cPAD) to the respective estimated dietary

exposures. Ty

picall y, ARIA has concerns regarding dietary risk when the estimates exceed 100% of the aPAD or cPAD. With the conservative assumptions noted above, risk estimates associated with dietary exposure to flumioxazin are significantl y below ARIA’s level of concern . Both the acute and chronic exposure anal ys es were performed assuming tolerance - level residues of flumiox azin for all commodities with existing and ARIA recommended tolerances , empirical processing factors obtained from processing studies (tomatoes) a long with DEEM 7.81 default processing factors for the remaining processed commodities, 100% crop treated (CT) and an estimated drinking water concentration (EDWC) of 0.048 ppm for flumioxazin. Acute Dietary (Food + Drinking W ater) Exposure Results and Characterization There were no appropriate toxicological effects attributable to a single exposure (dose) for the general population or an y other population subgroups except females 13 - 49 year s old ; therefore , these population subgroups were not included in this assessment. An acute dietary

assessment was conducted only for the population subgroup females 13 - 49 ye ars old. For food and drinking water, the exposure to females 13 - 49 years old ut ilized 9 % of the aPAD at the 95th percentile of exposure distribution. The acute dietary risk assessment for flumioxazin shows that for all included commodities, the acute dietary risk estimates are below ARIA’s level of concern (i.e. <100% aPAD). Chro nic Dietary (Food + Drinking W ater) Exposure Results and Characterization A chronic dietary

assessment was conducted for the general U.S. population and all population subgroups. For the general U.S. population the exposure for food and drinking water ut ilized 7 % of the cPAD. The chronic dietary risk estimate for the highest reported exposed population subgroup, all infants (<1 year old) , is 19 % of the cPAD.Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

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### The chronic dietary

risk assessment shows that for all included commodities, the chronic dietary risk estimates are below ARIA’s level of concern (i.e. <100% chronic population adjusted doses (cPAD). Cancer Exposure Results and Characterization Flumioxazin was classified as “Not likel y to be Carcinogenic to Humans” based on the lack of carcinogeni city

in a 2 - year rat study, an 18 - month mouse study , and a battery of mutagenic studies ; therefore, no cancer assessment was performed. I. Introduction Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and c hronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which ARIA has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population adjusted dose (PAD). The PA D is equivalent to point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty

or safet y factors. For acute and non - cancer chronic exposures, ARIA is concerned when estimated dietary risk exceeds 100% of the PAD. ARIA is generally concerned when estimated cancer risk exceeds one in one million (i.e., the risk exceeds 1 x 10 - 6 

### ). References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Asse ssing Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link: http://www.epa.gov/fedrgstr/EPA - PEST/2000/July /Day 12/6061.pdf ; or see SOP 99.6 (8/20/99). The most r ecent dietary

risk assessment for flumioxazin was conducted by B. Hanson ( PP#7F7243, DP#: 342414 , 3/5/08 ). II. Residue Information Tolerances: Tolerances are currentl y established for residues of the herbicide flumioxazin in/on various plant commodities , at levels ranging from 0.02 to 8. 0 ppm (as listed in e - CFR 40 §180.568 [a] , Updated June 1 , 200 9 ). Residue of Concern : The residue of concern for both the tolerance expression and risk assessment in plants is flumioxazin per se . The residue of concer n for both the tolerance expression and risk assessment in fish is flumioxazin and its metabolites APF (3 - oxo - 4 - prop - 2y nyl - 6 - amino - 7 - fluoro - 3,4 - dihydro - 1,4 - benzoxazin) and 482 - HA (N - (7 - fluoro - 3,4 - dihdy ro - 3 - oxo - 4 - prop - 2 - yn yl - 2H - 1,4 - benzoxazin - 6 - yl )cyclohex - 1 - ene - 1 - carboxamide - 2 - carbox yl ic acid), each expressed as parent equivalents . Residue Data Used for Dietary Assessment s : Previously , residue data from field trials conducted to support the existing registrations show that, generally , residues of flumioxazin are low, and that residues do not concentrate into processed products;Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

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### therefore, use of default processing factors in the anal ys is is considered conservative and will overestimate dietary

exposure. Current and ARIA recommended tolerance - level residue s were used for all raw agricultural commodities ( RACs ) . DEEM  7.81 processing factors were used for all processed commodities, with the exception of tomato which used the empirical processing factor of one. A tomato processing factor of 1 is based on an exaggerated (~5x) crop field trial study in which no residues were recovered; therefore, a processing study is not required (47005106.der.com, D. Rate, 6/19/ 07). 100 %CT was assumed for all commodities in this assessment. As part of the current petitio n, ARIA recommends establishing tolerances : Fish, fresh water ................................ ................................ ............... 1.5 ppm Cucurbit vegetables group 9 ................................ ............................ 0.03 ppm Leaf petioles subgroup 4B ................................ ............................... 0.02 ppm Hops, dried cones ................................ ................................ ............. 0.0 5 ppm Because the aquatic applications of flumioxazin are prohibited to flowing water, int ertidal or estuarine areas and to water used for crawfish farming, residue data and tolerances are not required for shellfish or saltwater fishes. III. Drinking Water Data The drinking water residues used in the dietary risk assessment were provided by E FED in the following memorandum: “ Drinking Wa ter Assessment for: (1) IR - 4 Registration for Flumioxazin to be used on Asparagus, Dry Bean, Bushberry Subgroup 13B, Fruiting Vegetable Subgroup 8, Melon Subgroup 9A, Okra and Tree Nut Subgroup 14; and (2) Secti on 3 Registration for Use on Field Corn and Alfalfa (DP#: D336195, 342249, 331732; L . Liu; 9/25/07) and incorporated directly into this dietary assessment. Water residues were incorporated in the DEEM - FCID into the food categories “water, direct, all sour ces” and “water, indirect, all sources .” The hydroly sis study

for flumioxazin indicates that flumioxazin forms the metabolite 482 - HA, which can further h ydrol yz e to the metabolites APF and THPA. The rates of the two hydroly

tic reactions are very

pH depe ndent, but flumioxazin (parent compound) is not very

stable at any

likely environmental pH. Data also indicates that THPA and APF are likely

to be very mobile. Although THPA can comprise a major portion of the total residue in water, it does not possess the phenyl ring and is thus considered significantl y less toxic than parent, APF, and 482 - HA. Thus, THPA has not been included in the residue of concern for drinking water. Therefore, parent flumioxazin and the metabolites 482 - HA and APF are the residues of concern in drinking water. The EDWCs for flumioxazin residues (used in both the acute and chronic dietary anal ys es) was 0.048 ppm, the concentration in groundwater as estimated b y the Screening Concentration In GroundWater ( SCI - GROW ) model. SCI - GROW is an empirical model for predicting pesticide levels in groundwater; the value from SCI - GROW is consideredFlumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

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### an upper bound concentration estimate, and thus conservative. In order to be conservative with the estimates, the groundwater EDWC (0.048 ppm), gre ater than the surface water EDWC (0.034 ppm), was used in both dietary anal ys es Table 1 summarizes the drinking water concentrations provided by EFED. The model and its description are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/ . Table 1 . EDW Cs for Flumioxazin and its Degradates in S urface W ater and G roundwater at pH 7. 1 Compound Average 56 - Day

Conc. in Surface Water Peak Conc. in

Surface Water Conc. in

Ground water Flumioxazin negligible 1.03 ppb negligible 482 - HA 4.84 ppb 6.87 ppb 45.27 ppb APF 12.85 ppb 26.46 ppb 2.66 ppb TH PA 19.50 ppb 27.67 ppb 182.28 ppb 1 Total EDWC = Flumioxazin + 482 - HA + APF 

### IV . DEEM - FCIDTM Program and Consumption Information Flumioxazin acute and chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM - FCIDTM, Version 2.03), which incor porates consumption data from USDA’s Continuing Survey s of Food Intakes by Individuals (CSFII), 1994 - 1996 and 1998. The 1994 - 96, 98 data are based on the reported consumption of more than 20,000 individuals over two non - consecutive survey day s. Foods “as consumed” (e.g., apple pie) are linked to EPA - defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicl y available recipe translation files developed jointly

by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events. Based on analy sis of the 1994 - 96, 98 CSFII consumption data, which took into account dietary

patterns and survey

respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1 - 2, children 3 - 5, children 6 - 12, youth 13 - 19, adults 20 - 49, females 13 - 49, and adults 50+ ye ars old. For chronic dietary

exposure assessment, an estimate of the residue level in each food or food - form (e.g., orange or orange juice) on the food commodity resid ue list is multiplied by the average dail y consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kgFlumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

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### body weight/day

and as a percent of the cPAD. This procedure is performed for each population subgroup. For acute exposure assessments , individual one - day food consumption data are used on an individual - by - individual basis. The reported consumption amounts of each food item can be multiplied by

a residue point estimate and summed to obtain a total daily pesticide exposure for a determin istic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., onl y those who reported eating relevant commodities/food forms) and a per capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy , per capita exposure and risk are reported for all tiers of anal ys is. However, for tiers 1 and 2, any significant differences in user vs. per capita exposure and risk are specificall y identified and noted in the risk assessment. V. Toxicological Information The findings of the flumioxazin risk assessment team, relativ e to dietary exposure, are summarized in Table 2 (below). In accordance with the EPA Draft Guidelines for Carcinogen Risk Assessment (July , 1999), flumioxazin was classified as “not likely to be carcinogenic to humans.” Table 2 . Summary of Toxicologic al Doses and Endpoints for Use in Human Health Dietary Risk Assessment for Flumioxazin. Exposure/ Scenario Point of

Departure Uncertainty/

FQPA Safety Factors RfD, PAD,

Level of Concern Study and Toxicological

Effects Ac ute Dietary (General Population , including Infants and Children) No endpoint attributable to a single dose (exposure) was identified in the available

studies, including the developmental toxicity studies in rats and rabbits.

Ac ute Dietary (Females 13 - 49 years of age) NOAEL = 3

mg/kg/ day UF A= 10x

UF H = 10x FQPA SF = 1X Total UF = 100X Acute RfD =

NOAEL  UF = 0.03 m g/kg/day aPAD = 0.03 mg/kg/day Oral developmental and

supplemental prenatal studies in the rat. LOAEL = 10 mg/kg/day based on cardiovascular effects (especially ventri cular septal defects in fetuses). Chronic Dietary (All Populations) NOAEL = 2

mg/kg/day UF A= 10x

UF H = 10x FQPA SF = 1X Chronic RfD 

FQPA SF = 0.02 m g/kg/day cPAD = 0.02 2 - year chronic/carcinogenicity

study in the rat. LO AE L = 18 mg/kg/day based on increased chronic nephropathy in males, and decreased hematologicalFlumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

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Page 7 of 15 Total UF = 100X mg/kg/day parameters in females (Hgb, MCV, MCH, and MCHC). Cancer (oral, dermal, inhalation) Classification: “Not likely to be Carcinogenic to Humans” based on the lack of carcinogenicity in a 2 - year rat study, an 18 - month mouse study, and a battery of mutagenic studies. Point of Departure (POD) = A data point or an estimated point that is derived from observed dose - response data and used to mark the beginning o f extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (intraspecies). UF H = potential variation in sensitivity among members of the human population (interspecies). UF L = use of a LOAEL to extrapolate a NOAEL. UF S = use of a short - term study for long - term risk assessment. UF DB = to account for the absence of key data (i.e., lack of a critical study). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose. LOC = level of concern. N/A = not applicable. 

### V I . Results/Discussion As stated above, for ac ute or chronic dietary assessments, ARIA is concerned when dietary risk exceeds 100% of the PAD. The DEEM - FCID  analy ses estimate the dietary exposure of the US population and various population subgroups. The results reported in Table 3 (below) are for the general US population (total), all infants <1, children 1 - 2, children 3 - 5, children 6 - 12, youths 13 - 19, females 13 - 49, adults 20 - 49, and adults 50+ for chronic exposure and females 13 - 49 for acute exposure. Results of Acute Dietary

Exposure Analy sis Flumioxazin acute dietary (food + water) exposure estimates using the DEEM - FCIDTM software are below ARIA’s level of concern for females 13 - 49 . The acute dietary exposure for the females, 13 - 49 years old, utilized 9 % of the aPAD. Results of Chronic Diet ary Exposure Analy sis Flumioxazin chronic dietary (food + water) exposure estimates using the DEEM - FCIDTM software are below ARIA ’s level of concern for the U.S. population and each of the population subgroups . Chronic dietary exposure utilized 7 % of the cPAD for the U.S. population. T he chronic dietary exposure for the highest reported exposed population subgroup, all infants (<1 year old) , was 19 % of the cPAD . The results of the acute and chronic dietary exposure anal ys e s are reported in the Summary Ta ble (Table 3 , below). TABLE 3 . Summary of Dietary Exposure and Risk for Flumioxazin. Population Subgroup 1 DEEM Acute Dietary Analysis, 95 th Percentile DEEM Chronic Dietary AnalysisFlumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

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Page 8 of 15 aPAD (m g/kg) Exposure

(m g/kg/day) % aPAD cPAD (m g/kg/day) Exp osure

(m g/kg/day) % cPAD General U.S. Population NA 2 0.02 0.001 307 7 All Infants (< 1 year old) 0.02 0.0037 61 19 Children 1 - 2 years old 0.02 0.0022 89 11 Children 3 - 5 years old 0.02 0.0021 20 11 Children 6 - 12 years old 0.02 0.001433 7 Youth 13 - 1 9 years old 0.02 0.000980 5 Adults 20 - 49 years old 0.02 0.001165 6 Adults 50+ years old 0.02 0.00122 5 6 Females 13 - 49 years old 0.03 0. 0027 34 9 0.02 0.0011 6 5 6 1 Values for the population with the highest risk for each type of risk assessment are bo lded . 2 NA = Not Applicable; no acute dietary endpoint was identified for these population subgroups 

### VII. Characterization of Inputs/Outputs The assumptions made in this assessment are conservative, and are very likely to result in exposure and risk v alues that considerabl y overestimate actual dietary exposure to flumioxazin. Although not needed at this time, the anal y se s could be further refined through the use of average residues based on field trial data, percent crop treated data and/or preparatio n/cooking factors. Since risk estimates are below ARIA’s level of concern, a more highl y refined analysis is not needed at this time . VI I I . Conclusions Based on conservative assumptions, dietary risk estimates for flumioxazin do not exceed ARIA’s level of concern for the general U . S . population, nor did any of the population subgroups, including those comprise d of infants and children. For the acute anal ys is, there were no differences between user vs. per capita exposure and risk. I X . List of Attachmen ts Attachment 1: Food plus Water Residue Input File Attachment 2: Acute Results File Attachment 3 : Chronic Results File Attachment 4 : Chemical Structure of Flumioxazin and metabolites (482 - HA and APF)

used in the EDWCs.Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

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### Attachment 1: Food plus Water Residue Input File

U .S. Environmental Protection Agency Ver. 2.00 DEEM - FCID Chronic analysis for FLUMIOXAZIN 1994 - 98 data Residue file: G: \ 129034c.r98 Adjust. #2 NOT used Analysis Date 06 - 04 - 2009 Residue file dated: 06 - 04 - 2009/10:40:15/8 Reference dose (RfD) = 0.02 mg/kg bw/day

-------------------------------------------------------------------------------- Food Crop Residue Adj.Factors Comment EPA Code Grp Food Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ----- - ------ ------- 14000030 14 Almond 0.020000 1.000 1.000 14000031 14 Almond - babyfood 0.020000 1.000 1.000 14000040 14 Almond, oil 0.020000 1.000 1. 000 14000041 14 Almond, oil - babyfood 0.020000 1.000 1.000 11000070 11 Apple, fruit with peel 0.020000 1.000 1.000 11000080 11 Apple, peeled fruit 0.020000 1.000 1.000 11000081 11 Apple, peeled fruit - babyfood 0.020000 1.000 1.000 11000090 11 Apple, dried 0.020000 8.000 1.000 11000091 11 Apple, dried - babyfood 0.020000 8.000 1.000 11000100 11 Apple, juic e 0.020000 1.300 1.000 11000101 11 Apple, juice - babyfood 0.020000 1.300 1.000 11000110 11 Apple, sauce 0.020000 1.000 1.000 11000111 11 Apple, sauce - babyfood 0.020000 1.000 1.000 12000120 12 Apricot 0.020000 1.000 1.000 12000121 12 Apricot - babyfood 0.020000 1.000 1.000 12000130 12 Apricot, dried 0.020000 6.000 1.000 12000140 12 Apricot, juice 0.020000 1.000 1.000 12000141 12 Apricot, juice - babyfood 0.020000 1.000 1.000 01030150 1CD Arrowroot, flour 0.020000 1.000 1. 000 01030151 1CD Arrowroot, flour - babyfood 0.020000 1.000 1.000 01030170 1CD Artichoke, Jerusalem 0.020000 1.000 1.000 95000190 O Asparagus 0.020000 1.000 1.000 09020210 9B Balsam pear 0.030000 1.000 1.000 06030300 6C Bean, black, seed 0.050000 1.000 1.000 06030320 6C Bean, broad, seed 0.050000 1.000 1.000 06030340 6C Bean, cowpe a, seed 0.050000 1.000 1.000 06030350 6C Bean, great northern, seed 0.050000 1.000 1.000 06030360 6C Bean, kidney, seed 0.050000 1.000 1.000 06030380 6C Bean, lima, seed 0.050000 1.000 1.000 06030390 6C Bean, mung, seed 0.050000 1.000 1.000 06030400 6C Bean, navy, seed 0.050000 1.000 1.000 06030410 6C Bean, pink, seed 0.050000 1.000 1.000 06030420 6C Bean, pinto, seed 0.050000 1.000 1.000 13020570 13B Blueberry 0.020000 1.000 1.000 13020571 13B Blueberry - babyfood 0.020000 1.000 1. 000 14000590 14 Brazil nut 0.020000 1.000 1.000 14000680 14 Butternut 0.020000 1.000 1.000 09010750 9A Cantaloupe 0.030000 1.000 1.000 04020760 4B Cardoon 0.020000 1.000 1.000 09010800 9A Casaba 0.030000 1.000 1.000 14000810 14 Cashew 0.020000 1.000 1.000 01030820 1CD Cassava 0.020000 1.000 1.000 01030821 1CD Cassava - babyfood 0.020000 1.000 1.000 04020850 4B Celery 0.020000 1.000 1.000 04020851 4B Celery - babyfood 0.020000 1.000 1.000 04020860 4B Celery, juice 0.020000 1.000 1.000 04020870 4B Celtuce 0.020000 1.000 1.000 09020880 9B Chayote, fruit 0.030000 1.000 1.000 12000900 12 Cherry 0.020000 1.000 1.000 12000901 12 Cherry - babyfood 0.020000 1.000 1.000 12000910 12 Cherry, juice 0.020000 1.500 1. 000 12000911 12 Cherry, juice - babyfood 0.020000 1.500 1.000 14000920 14 Chestnut 0.020000 1.000 1.000 09021020 9B Chinese waxgourd 0.030000 1.000 1.000 15001200 15 Corn, field, flour 0.020000 1.000 1.000Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

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Page 10 of 15 15001201 15 Corn, field, flour - babyfood 0.020000 1.000 1.000 15001210 15 Corn, field, meal 0.020000 1.000 1.000 15001211 15 Corn, field , meal - babyfood 0.020000 1.000 1.000 15001220 15 Corn, field, bran 0.020000 1.000 1.000 15001230 15 Corn, field, starch 0.020000 1.000 1.000 15001231 15 Corn, field, starch - babyfoo d 0.020000 1.000 1.000 15001240 15 Corn, field, syrup 0.020000 1.500 1.000 15001241 15 Corn, field, syrup - babyfood 0.020000 1.500 1.000 15001250 15 Corn, field, oil 0.020000 1.000 1.000 15001251 15 Corn, field, oil - babyfood 0.020000 1.000 1.000 95001280 O Cottonseed, oil 0.020000 1.000 1.000 95001281 O Cottonseed, oil - babyfood 0.020000 1.000 1. 000 11001290 11 Crabapple 0.020000 1.000 1.000 95001300 O Cranberry 0.020000 1.000 1.000 95001301 O Cranberry - babyfood 0.020000 1.000 1.000 95001310 O Cranberry, dried 0.020000 1.000 1.000 95001320 O Cranberry, juice 0.020000 1.100 1.000 95001321 O Cranberry, juice - babyfood 0.020000 1.100 1.000 09021350 9B Cucumber 0.030000 1.000 1.000 13021360 13B Currant 0.020000 1.000 1.000 13021370 13B Currant, dried 0.020000 1.000 1.000 01031390 1CD Dasheen, corm 0.020000 1.000 1.000 08001480 8 Eggplant 0.020000 1.000 1.000 13021490 13B Elderberry 0.020000 1.000 1.000 04021520 4B Fennel, Florence 0.020000 1.000 1.000 14001550 14 Filbert 0.020000 1.000 1.000 14001560 14 Filbert, oil 0.020000 1.000 1.000 80001570 F Fish - freshwater finfish 1.500000 1.000 1. 000 80001580 F Fish - freshwater finfish, farm ra 1.500000 1.000 1.000 03001640 3 Garlic 0.020000 1.000 1.000 03001650 3 Garlic, dried 0.020000 1.000 1.000 03001651 3 Garlic, dried - babyfood 0.020000 1.000 1.000 01031660 1CD Ginger 0.020000 1.000 1.000 01031661 1CD Ginger - babyfood 0.020000 1.000 1.000 01031670 1CD Ginger, dri ed 0.020000 1.000 1.000 13021740 13B Gooseberry 0.020000 1.000 1.000 95001750 O Grape 0.020000 1.000 1.000 95001760 O Grape, juice 0.020000 1.200 1.000 95001761 O Grape, juice - babyfood 0.020000 1.200 1.000 95001770 O Grape, leaves 0.020000 1.000 1.000 95001780 O Grape, raisin 0.020000 4.300 1.000 95001790 O Grape, wine and sherry 0.020000 1.000 1.000 14001850 14 Hickory nut 0.020000 1.000 1.000 09011870 9A Honeydew melon 0.030000 1.000 1. 000 95001880 O Hop 0.050000 1.000 1.000 13021910 13B Huckleberry 0.020000 1.000 1.000 11002100 11 Loquat 0.020000 1.000 1.000 14002130 14 Macadamia nut 0.020000 1.000 1.000 12002300 12 Nectarine 0.020000 1.000 1.000 08002340 8 Okra 0.020000 1.000 1.000 03002370 3 Onion, dry bulb 0.020000 1.000 1.000 03002371 3 Onion, dry bulb - babyfood 0.020000 1.000 1.000 03002380 3 Onion, dry bulb, dried 0.020000 9.000 1.000 03002381 3 Onion, dry bulb, dried - baby food 0.020000 9.000 1.000 03002390 3 Onion, green 0.020000 1.000 1.000 12002600 12 Peach 0.020000 1.000 1.000 12002601 12 Peach - babyfood 0.020000 1.000 1.000 12002610 12 Peach, dried 0.020000 7.000 1.000 12002611 12 Peach, dried - babyfood 0.020000 7.000 1.000 12002620 12 Peach, juice 0.020000 1.000 1. 000 12002621 12 Peach, juice - babyfood 0.020000 1.000 1.000 95002630 O Peanut 0.020000 1.000 1.000 95002640 O Peanut, butter 0.020000 1.890 1.000 95002650 O Peanut, oil 0.020000 1.000 1.000 11002660 11 Pear 0.020000 1.000 1.000 11002661 11 Pear - babyfood 0.020000 1.000 1.000 11002670 11 Pear, dried 0.020000 6.250 1.000 11002680 11 Pear, juice 0.020000 1.000 1.000 11002681 11 Pear, juice - babyfood 0.020000 1.000 1.000 14002690 14 Pecan 0.020000 1.000 1.000Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

PC Code: 129034

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Page 11 of 15 08002700 8 Pepper, bell 0.020000 1.000 1.000 08002701 8 Pepper, bell - babyfood 0.020000 1.000 1.000 08002710 8 Pepper, bell, dried 0.020000 1.000 1.000 08002711 8 Pepper, bell, dried - babyfood 0.020000 1.000 1.000 08002720 8 Pepper, nonbell 0.020000 1.000 1.000 08002721 8 Pepper, nonbell - babyfood 0.020000 1.000 1. 000 08002730 8 Pepper, nonbell, dried 0.020000 1.000 1.000 95002750 O Peppermint 0.040000 1.000 1.000 14002820 14 Pistachio 0.020000 1.000 1.000 12002850 12 Plum 0.020000 1.000 1.000 12002851 12 Plum - babyfood 0.020000 1.000 1.000 12002860 12 Plum, prune, fresh 0.020000 1.000 1.000 12002861 12 Plum, prune , fresh - babyfood 0.020000 1.000 1.000 12002870 12 Plum, prune, dried 0.020000 5.000 1.000 12002871 12 Plum, prune, dried - babyfood 0.020000 5.000 1.000 12002880 12 Plum, prune, juice 0.020000 1.400 1.000 12002881 12 Plum, prune, juice - babyfood 0.020000 1.400 1.000 01032960 1C Potato, chips 0.020000 1.000 1.000 01032970 1C Potato, dry (granules/ flakes) 0.020000 6.500 1.000 01032971 1C Potato, dry (granules/ flakes) - b 0.020000 6.500 1.000 01032980 1C Potato, flour 0.020000 6.500 1.000 01032981 1C Potato, flour - babyfood 0.020000 6.500 1. 000 01032990 1C Potato, tuber, w/peel 0.020000 1.000 1.000 01032991 1C Potato, tuber, w/peel - babyfood 0.020000 1.000 1.000 01033000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 01033001 1C Potato, tuber, w/o peel - babyfood 0.020000 1.000 1.000 09023080 9B Pumpkin 0.030000 1.000 1.000 09023090 9B Pumpkin, seed 0.030000 1.000 1.000 11003100 11 Quince 0.020000 1.000 1.000 04023220 4B Rhubarb 0.020000 1.000 1.000 03003380 3 Shallot 0.020000 1.000 1.000 06003470 6 Soybean, seed 0.020000 1.000 1.000 06003480 6 Soybean, flour 0.020000 1.000 1.000 06003481 6 Soybean, flour - babyfood 0.020000 1.000 1.000 06003490 6 Soybean, soy milk 0.020000 1.000 1.000 06003491 6 Soybean, soy milk - babyfood or in 0.020000 1.000 1.000 06003500 6 Soybean, oil 0.020000 1.000 1.000 06003501 6 Soybean, oil - babyfood 0.020000 1.000 1. 000 95003520 O Spearmint 0.040000 1.000 1.000 09023560 9B Squash, summer 0.030000 1.000 1.000 09023561 9B Squash, summer - babyfood 0.030000 1.000 1.000 09023570 9B Squash, winter 0.030000 1.000 1.000 09023571 9B Squash, winter - babyfood 0.030000 1.000 1.000 95003590 O Strawberry 0.070000 1.000 1.000 95003591 O Strawberry - babyfood 0.070000 1.000 1.000 95003600 O Strawberry, juice 0.070000 1.000 1.000 95003601 O Strawberry, juice - babyfood 0.070000 1.000 1.000 95003620 O Sugarcane, sugar 0.200000 1.000 1.000 95003621 O Sugarcane, sugar - babyfood 0.200000 1.000 1.000 95003630 O Sugarcane, molasses 0.200000 1.000 1.000 95003631 O Sugarcane, molasses - babyfood 0.200000 1.000 1.000 01033660 1CD Sweet potato 0.020000 1.000 1.000 01033661 1CD Sweet potato - babyfood 0.020000 1.000 1.000 04023670 4B Swiss chard 0.020000 1.000 1. 000 01033710 1CD Tanier, corm 0.020000 1.000 1.000 08003740 8 Tomatillo 0.020000 1.000 1.000 08003750 8 Tomato 0.020000 1.000 1.000 08003751 8 Tomato - babyfood 0.020000 1.000 1.000 08003760 8 Tomato, paste 0.020000 1.000 1.000 08003761 8 Tomato, paste - babyfood 0.020000 1.000 1.000 08003770 8 Tomato, pur ee 0.020000 1.000 1.000 08003771 8 Tomato, puree - babyfood 0.020000 1.000 1.000 08003780 8 Tomato, dried 0.020000 1.000 1.000 08003781 8 Tomato, dried - babyfood 0.020000 1.000 1.000 08003790 8 Tomato, juice 0.020000 1.000 1.000 01033870 1CD Turmeric 0.020000 1.000 1.000 14003910 14 Walnut 0.020000 1.000 1.000 86010000 O Water, direct, all sources 0.048000 1.000 1.000 86020000 O Water, indirect, all sources 0.048000 1.000 1.000 09013990 9A Watermelon 0.030000 1.000 1. 000Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

PC Code: 129034

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Page 12 of 15 09014000 9A Watermelon, juice 0.030000 1.000 1.000 01034060 1CD Yam, true 0.020000 1.000 1.000 01034070 1CD Yam bean 0.020000 1.000 1.000Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

PC Code: 129034

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Page 13 of 15 

### A ttachment 2: Acute Results File U.S. Environmental Protection Agency Ver. 2.02 DEEM - FCID ACUTE Analysis for FLUMIOXAZIN (1994 - 98 data) Residue file: 129034c.r98 Adjustment factor #2 NOT used. Analysis Date: 06 - 04 - 2009/11:46:48 Residue file dated: 06 - 04 - 2009/10:40:15/8 Daily totals for food and foodform consumption used. Run Comment: ""

============================================================================ === Summary calculations (per capita): 95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- ----- --- ---------- -------- Females 13 - 49 yrs: 0.002734 9.11 0.004778 15.93 0.009800 32.67 U.S. Environmental Protection Agency Ver. 2.02 DEEM - FCID ACUTE Analysis for FLUMIOXAZIN (1994 - 98 data) Residue file: 129034c.r98 Adjustment factor #2 NOT used. Analysis Date: 06 - 04 - 2009/11:46:48 Residue file dated: 06 - 04 - 2009/10:40:15/8 Acute Reference Dose (aRfD) = 0.030000 mg/kg body - wt/day Daily totals for food and foodform consumption used. Run Comment: ""

=============================================================================== Females 13 - 49 yrs Daily Exposure Analysis /a

----------------- (mg/kg body - w eight/day) per Capita per User

----------- ----------- Mean 0.001165 0.001165 Standard Deviation 0.000950 0.000950 Standard Error of mean 0.000012 0.000012 Percent of aRfD 3.88 3.88 Percent of Person - Days that are User - Days = 99.99%Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

PC Code: 129034

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Page 14 of 15 

### A ttachment 3 : Chronic Results File U.S. Environmental Protection Agency Ver. 2.00 DEEM - FCID Chronic analysis for FLUMIOXAZIN (1994 - 98 data) Residue file name: G: \ 129034c.r98 Adjustment factor #2 NOT used. Analysis Date 06 - 04 - 2009/11:44:53 Residue file dated : 06 - 04 - 2009/10:40:15/8 Reference dose (RfD, Chronic) = .02 mg/kg bw/day

=============================================================================== Total exposure by population subgroup

--------------------------------------------- ---------------------------------- Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- --------------- U.S. Population (total) 0.001307 6.5% U.S. Population (spring se ason) 0.001306 6.5% U.S. Population (summer season) 0.001393 7.0% U.S. Population (autumn season) 0.001271 6.4% U.S. Population (winter season) 0.001255 6.3% Northeast region 0.001194 6.0% Midwest region 0.001322 6.6% Southern region 0.001251 6.3% Western region 0.001481 7.4% Hispanics 0.001452 7.3% Non - hispanic whites 0.001271 6.4% Non - hispanic blacks 0.001280 6.4% Non - hisp/non - white/non - black 0.001631 8.2% All infants (< 1 year) 0.003761 18.8% Nursing infants 0.001448 7.2% Non - nursing infants 0.004639 23.2% Children 1 - 6 yrs 0.002130 10.6% Children 7 - 12 yrs 0.001361 6.8% Females 13 - 19 (not preg or nursing) 0.000944 4.7% Females 20+ (not preg or nursing) 0.001229 6.1% Females 13 - 50 yrs 0.001216 6.1% Females 13+ (preg/not nursing) 0.001211 6.1% Females 13+ (nursing) 0.001684 8.4% Males 13 - 19 yrs 0.001010 5.0% Males 20+ yrs 0.001135 5.7% Seniors 55+ 0.001229 6.1% Children 1 - 2 yrs 0.002289 11.4% Children 3 - 5 yrs 0.002120 10.6% Children 6 - 12 yrs 0.001433 7.2% Youth 13 - 19 yrs 0.000980 4.9% Adults 20 - 49 yrs 0.001165 5.8% Adults 50+ yrs 0.001225 6.1% Females 13 - 49 yrs 0.001165 5.8%

-------------------------------------------------------------------------------Flumioxazin Dietary Exposure and Risk Assessment DP Number: 367978

PC Code: 129034

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Page 15 of 15 

### Attachment 4 : Chemical Structure of Flumioxazin and metabolites (482 - HA and APF) used in the EDWCs. Chemical Name Structur e Flumioxazin 2 - [7 - fluoro - 3,4 - dihydro - 3 - oxo - 4 - (2 - propynyl) - 2H

- 1,4 - benzoxazin - 6 - yl] - 4,5,6,7 - tetrahydro - 1H - isoindole 1,3(2H) - dione N O N O

O

O F

C C H 482 - HA N - [7 - fluoro - 3 - oxo - 4 - (2 - propynyl) - 2H - 1,4 - benzoxazin - 6 - yl] - 3,4,5,6 - tetrahydrophthalamic acid O H O O N H O N O F

C C H APF 6 - amino - 7 - fluoro - 4 - (2 - propenyl) - 2H - 1,4 - benzoxazin - 3(4H) - one O N O F N H 2

C H C