EX-10.35





 Exhibit 10.35 

AMENDED AND RESTATED EMPLOYMENT AGREEMENT 

This AMENDED AND RESTATED EMPLOYMENT AGREEMENT (this “Agreement”), dated as of March 1, 2018 (the
“Effective Date”) is by and between ADGERO BIOPHARMACEUTICALS HOLDINGS, INC., a Delaware corporation (the “Company”) and John Liatos (the “Employee”). 

W I T N E S S E T H: 

WHEREAS, the Company employs the Employee as its Chief Financial Officer pursuant to the terms of an employment agreement dated
October 11, 2017 (the “Prior Employment Agreement”); and 
 WHEREAS, the Company and the Employee have mutually
agreed that, as of the Effective Date, this Agreement shall amend, restate and replace the Prior Employment Agreement and this Agreement shall govern the terms of employment between the Employee and the Company. 

NOW, THEREFORE, in consideration of the promises and the mutual covenants and agreements contained herein and other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto, intending to be legally bound hereby, agree as follows: 

ARTICLE 1 
 EMPLOYMENT;TERM OF
AGREEMENT 
 Section 1.1. Employment and Acceptance. During the Term (as defined in Section 1.2),
the Company shall employ the Employee, and the Employee shall accept such employment and serve the Company, in each case, subject to the terms and conditions of this Agreement. 

Section 1.2. Term. The employment relationship hereunder shall be for the period (such period of the employment relationship shall
be referred to herein as the “Term”) commencing on the Effective Date and ending upon the termination of the Employee’s employment hereunder by either party hereto pursuant to the terms of Section 4.1,
Section 4.2 or Section 4.3. In the event that the Employee’s employment with the Company hereunder terminates, the Company’s obligation to continue to pay, after the Termination Date (as
defined in Section 4.2(a)), Base Salary (as defined in Section 3.1(a)), Annual Bonus (as defined in Section 3.1(b)) and other unaccrued benefits shall terminate, except to
the extent provided for in ARTICLE 4. 
 ARTICLE 2 

TITLE; DUTIES AND OBLIGATIONS; LOCATION 

Section 2.1. Title. The Company shall employ the Employee to render exclusive and full-time services to the Company. The Employee
shall serve in the capacity of Chief Financial Officer. 












 Section 2.2. Duties. The Employee shall report to the Company’s Board of
Directors (the “Board”) or another executive designated by the Board (together with the Board, the Supervisor”) and be subject to the lawful direction of the Supervisor. The Employee agrees to perform to the best of his
ability, experience and talent those acts and duties, consistent with the position of Chief Financial Officer as the Supervisor shall from time to time direct. 

Section 2.3. Compliance with Policies, etc. During the Term, the Employee shall be bound by, and comply fully with, all of
the Company’s policies and procedures for employees in place from time to time, including, but not limited to, all terms and conditions set forth in the Company’s employee handbook, compliance manual, codes of conduct and any other
memoranda and communications applicable to the Employee pertaining to the policies, procedures, rules and regulations, as currently in effect and as may be amended from time to time. These policies and procedures include, among other things and
without limitation, the Employee’s obligations to comply with the Company’s rules regarding confidential and proprietary information and trade secrets. 

Section 2.4. Time Commitment. During the Term, the Employee shall use his best efforts to promote the interests of the Company
(including its subsidiaries and other Affiliates) and shall devote all of his business time, ability and attention to the performance of his duties for the Company. and shall not, directly or indirectly, render any services to any other person or
organization, whether for compensation or otherwise, except (with the Board) prior written consent, provided that the foregoing shall not prevent the Employee from (i) participating in charitable, civic, educational, professional, community or
industry affairs, or (ii) managing the Employee’s passive personal investments, so long as, in each case, such activities individually or in the aggregate do not materially interfere or conflict with the Employee’s duties hereunder or
create a potential business or fiduciary conflict (in each case, as determined by the Board). 
 Section 2.5. Location. The
Employee’s principal place of business for the performance of his duties under this Agreement shall be at the principal executive office of the Company, which is located at 4365 US Route 1 South, Suite 211, Princeton, New Jersey 08540 as of the
Effective Date. The Employee shall travel as determined necessary to perform his duties hereunder by the Supervisor. 
 ARTICLE 3 

COMPENSATION AND BENEFITS; EXPENSES 

Section 3.1. Compensation and Benefits. For all services rendered by the Employee in any capacity during the Term (including,
without limitation, serving as an officer, director or member of any committee of the Company or any of its subsidiaries or other Affiliates), the Employee shall be compensated as follows (subject, in each case, to the provisions of
ARTICLE 4 below): 
 (a) Base Salary. During the Term, effective as of January 1, 2018, the Company shall pay the
Employee a base salary (the “Base Salary”) at the annualized rate of $320,000, which shall be subject to customary withholdings and authorized deductions and be payable in equal installments in accordance with the Company’s
customary payroll practices in place from time to time. The Employee’s Base Salary and title shall be subject to, on an annual basis, periodic review and adjustments as the Board and/or the Compensation Committee of the Board (the
“Compensation Committee”) shall in its/their discretion deem appropriate. 

  
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 (b) Annual Bonus. For each calendar year ending during the Term (beginning with the
calendar year ending December 31, 2017), the Employee shall be eligible to receive an annual bonus (the “Annual Bonus”) with a target amount of up to thirty five percent (35%) of the Base Salary earned by the Employee for such
calendar year (the “Target Annual Bonus”). Notwithstanding the foregoing, for calendar year 2017, the Employee will be eligible to receive an Annual Bonus, pro-rated for the period between
October 11, 2017 and December 31, 2017. The actual amount of each Annual Bonus will be based upon the level of achievement of the Company’s corporate objectives and the Employee’s individual objectives, in each case, as
established by the Board or the Compensation Committee (taking into account the input of the Supervisor with respect to the establishment of the Employee’s individual objectives) for the calendar year with respect to which such Annual Bonus
relates. The determination of the level of achievement of the corporate objectives and the Employee’s individual performance objectives for a year shall be made by the Board or the Compensation Committee taking into account the input of the
Supervisor with respect to the establishment of the Employee’s individual objectives), in its reasonable discretion. Each Annual Bonus for a calendar year, to the extent earned, will be paid in a lump sum in the following calendar year, within
the first 75 days of such following year. The Annual Bonus shall not be deemed earned until the date that it is paid. Accordingly, in order for the Employee to receive an Annual Bonus, the Employee must be actively employed by the Company at the
time of such payment. 
 (c) Special Bonus. The Employee shall be eligible to receive a special
one-time bonus of $75,000, payable in a lump sum on the first business day following execution of this Agreement (the “Special Bonus”). 

(d) Equity Compensation. Subject to the terms of the Company’s 2016 Equity Incentive Plan (the “Plan”) and
approval of the Board or Compensation Committee, at the next regular meeting of the Board or the Compensation Committee on or following the Effective Date, the Employee will be granted options to purchase up to 40,000 shares of the Company’s
common stock, subject to shareholder approval of an increase in the number of shares available under the Plan, on the terms and conditions determined by the Board or the Compensation Committee, with an exercise price of $5.00 per share (provided
that the Board or the Compensation Committee determines that such exercise price represents no less than fair market value per share on the date of grant in accordance with the Plan). The shares subject to the option shall be fully vested upon
grant. During the Term, subject to the terms and conditions established within the Plan or any successor equity compensation plan as may be in place from time to time and separate award agreements, the Employee also shall be eligible to receive from
time to time stock options, stock unit awards, performance shares, performance units, incentive bonus awards, other cash-based awards and/or other stock-based awards (as permitted by the Plan), in amounts, if any, to be approved by the Board or the
Compensation Committee in its discretion. Notwithstanding anything in the Plan to the contrary, if (i) the Termination Date occurs at least six (6) months after October 11, 2017 and (ii) the Employee is terminated without Cause
(as defined in Section 4.1(b)) or resigns with Good Reason (as defined in Section 4.1(c)) within twenty-four (24) months following a Change in Control (as defined in Section 5.19), in lieu of the application of
Section 4.1(d)(ii), the Employee shall receive accelerated vesting of all 

  
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unvested options upon the Termination Date and all of the Employee’s outstanding vested stock options shall remain exercisable for a period of twelve (12) months, measured from the
Termination Date (but in no event later than the expiration date of their term); provided, however, that in the event stock options under the Plan are cancelled or otherwise terminated pursuant to the Plan in connection with such
Change in Control, the Employee’s stock options may be cancelled or otherwise terminated, as applicable, on terms no less favorable than those provided to other similarly situated option holders. This Section 3.1(d)
shall be deemed an amendment to each award agreement entered into by the Employee evidencing a grant of stock options, whether entered into prior to October 11, 2017 or during the Term (but, in no event shall this
Section 3.1(d) be deemed an amendment to any award agreement entered into after expiration of the Term). 
 (e)
Benefit Plans. The Employee shall be entitled to participate in all employee benefit plans and programs (excluding severance plans, if any) generally made available by the Company to executives of the Company, to the extent permissible under
the general terms and provisions of such plans or programs and in accordance with the provisions thereof. The Company may amend, modify or rescind any employee benefit plan or program and/or change employee contribution amounts to benefit costs
without notice in its discretion. 
 (f) Paid Vacation. The Employee shall be entitled to paid vacation days in accordance with the
Company’s vacation policies in effect from time to time for its executive team; provided, however, that the Employee shall be entitled to no less than fifteen (15) paid vacation days per calendar year during the Term. 

Section 3.2. Expense Reimbursement. The Company shall reimburse the Employee during the Term, in accordance with the
Company’s expense reimbursement policies in place from time to time, for all reasonable out-of-pocket business expenses incurred by the Employee in the performance
of his duties hereunder. In order to receive such reimbursement, the Employee shall furnish to the Company documentary evidence of each such expense in the form required to comply with the Company’s policies in place from time to time. 

ARTICLE 4 
 TERMINATION OF
EMPLOYMENT 
 Section 4.1. Termination Without Cause or Resignation for Good Reason. 

(a) The Company may terminate the Employee’s employment hereunder at any time without Cause (other than by reason of death or Disability).
Employee may terminate his employment hereunder for Good Reason upon written notice to the Company in accordance with the provisions set forth in Section 4.1(c). 

(b) As used in this Agreement, “Cause” means: (i) a material act, or act of fraud, committed by the Employee that is
intended to result in the Employee’s personal enrichment to the detriment or at the expense of the Company or any of its Affiliates; (ii) the Employee is convicted of a felony; (iii) gross negligence or willful misconduct by the
Employee, or failure by the Employee to perform the duties or obligations reasonably assigned to the Employee by the the Supervisor (or the Board) from time to time, which is not cured upon ten (10) days prior written notice (unless such
negligence, misconduct or failure is not susceptible to cure, as determined in the reasonable discretion of the Board); or (iv) the Employee violates the Covenants Agreement (as defined in Section 5.1 below). 

  
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 (c) As used in this Agreement, “Good Reason” means the occurrence of any of
the following: (1) a material breach by the Company of the terms of this Agreement; (2) a material reduction in the Employee’s Base Salary (other than pursuant to a reduction uniformly applicable to all executives of the Company); or
(3) a material diminution in the Employee’s authority, duties or responsibilities; provided, however, that the Employee must notify the Company within ninety (90) days of the occurrence of any of the foregoing conditions
that he considers it to be a “Good Reason” condition and provide the Company with at least thirty (30) days in which to cure the condition. If the Employee fails to provide this notice and cure period prior to his resignation, or
resigns more than six (6) months after the initial existence of the condition, his resignation will not be deemed to be for “Good Reason.” It is an express condition of this Agreement that an acquiring entity in a Change in Control
assume this Agreement; if this Agreement is not so assumed, it shall constitute a material breach of the terms of the Agreement. 
 (d) If
the Employee’s employment is terminated pursuant to Section 4.1(a), the Employee shall, in full discharge of all of the Company’s obligations to the Employee, be entitled to receive, and the Company’s sole
obligation to the Employee under this Agreement or otherwise shall be to pay or provide to the Employee, the following: 

(i) the Accrued Obligations (as defined in Section 4.2(b)); 

(ii) if the Termination Date occurs at least six (6) months after October 11, 2017 during which period the Employee
performed continuous service for the Company, for each outstanding stock option held by the Employee under the Plan for which vesting is time-based, accelerated vesting upon the Termination Date as if the Employee had provided service to the Company
for an additional six (6) months (i.e., if there is annual vesting, stock options representing one-half (six months out of twelve) of the stock options that would have vested on the next annual
vesting date will vest on the Termination Date), and all of the Employee’s outstanding vested stock options shall remain exercisable for a period of twelve (12) months, measured from the Termination Date (but in no event later than the
expiration date of their term); and 
 (iii) subject to Section 4.4 and
Section 4.5: 
 (A) the Employee will be eligible to receive payments equal to the sum of eight
(8) months’ of the Employee’s Base Salary at the rate in effect immediately prior to the Termination Date (provided that if such salary has been reduced, the pre-reduction Base Salary (less
applicable withholdings and authorized deductions) (the “Severance Payments”) to be paid (subject to Section 5.16) in equal installments bimonthly (for clarity, two times per month) in accordance with the
Company’s regular payroll practices, commencing on the next regular payroll date that occurs on or after the sixtieth (60th) day following the Termination Date; and 

  
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 (B) monthly payments equal to the amount of the monthly cost to Employee of
healthcare coverage for Employee and his dependents at such rate as is in effect on the Termination Date, for the period beginning on the day following the Termination Date and ending on the earlier of: (A) the eight (8) month anniversary
of the Termination Date; and (B) the date the Employee becomes eligible to obtain alternate healthcare coverage from a new employer (the “Additional Payments”). The Employee agrees to immediately inform the Company if he
becomes eligible to obtain alternate healthcare coverage from a new employer. For the avoidance of doubt, the Employee is permitted to use the Additional Payments for any purpose. Notwithstanding anything set forth in this
Section 4.1(d)(iii)(C), if and to the extent that the Company may not provide such Additional Payments without incurring tax penalties or violating any requirement of the law, the Company shall use its commercially reasonable best efforts to
provide substantially similar assistance in an alternative manner provided that the cost of doing so does not exceed the cost that the Company would have incurred had the Additional Payments been provided in the manner described above or cause a
violation of Section 409A (as defined in Section 5.16). 
 Section 4.2. Termination for Cause; Voluntary Termination.
The Company may terminate the Employee’s employment hereunder at any time for Cause upon written notice to the Employee. The Employee may voluntarily terminate his employment hereunder at any time without Good Reason upon sixty (60) days
prior written notice to the Company; provided, however, the Company reserves the right, upon written notice to the Employee, to accept the Employee’s notice of resignation and to accelerate such notice and make the Employee’s resignation
effective immediately, or on such other date prior to Employee’s intended last day of work as the Company deems appropriate. It is understood and agreed that the Company’s election to accelerate Employee’s notice of resignation shall
not be deemed a termination by the Company without Cause for purposes of Section 4.1 of this Agreement or otherwise or constitute Good Reason (as defined in Section 4.1) for purposes of Section 4.1 of this Agreement or otherwise. If
the Employee’s employment is terminated pursuant to Section 4.2, the Employee shall, in full discharge of all of the Company’s obligations to the Employee, be entitled to receive, and the Company’s sole obligation under this
Agreement or otherwise shall be to pay or provide to the Employee, the following (collectively, the “Accrued Obligations”): 

(a) the Employee’s earned, but unpaid, Base Salary through the final date of the Employee’s employment by the Company (the
“Termination Date”), payable in accordance with the Company’s standard payroll practices; 
 (b) the Employee’s
accrued, but unused, vacation (in accordance with the Company’s policies); 
 (c) expenses reimbursable under
Section 3.2 above incurred on or prior to the Termination Date but not yet reimbursed; and 
 (d) any amounts or
benefits that are vested amounts or vested benefits or that the Employee is otherwise entitled to receive under any Company plan, program, policy or practice (with the exception of those, if any, relating to severance) on the Termination Date, in
accordance with such plan, program, policy, or practice. 

  
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 Section 4.3. Termination Resulting from Death or Disability. 

(a) As the result of any Disability suffered by the Employee, the Company may, upon five (5) days prior notice to the Employee, terminate
the Employee’s employment under this Agreement. The Employee’s employment shall automatically terminate upon his death. 
 (b)
“Disability” means a determination by the Company in accordance with applicable law that as a result of a physical or mental injury or illness, the Employee has been unable to perform the essential functions of his job with or
without reasonable accommodation for a period of (i) ninety (90) consecutive days; or (ii) one hundred twenty (120) days during any twelve (12) month period. 

(c) If the Employee’s employment is terminated pursuant to Section 4.3(a), the Employee or the Employee’s
estate, as the case may be, shall be entitled to receive, and the Company’s sole obligation under this Agreement or otherwise shall be to pay or provide to the Employee or the Employee’s estate, as the case may be, the Accrued Obligations.

 Section 4.4. Release Agreement. In order to receive the Severance Payments or the Additional Payments set forth in
Section 4.1, the Employee must timely execute (and not revoke) a separation agreement and general release (the “Release Agreement”) in a customary form as is determined to be reasonably necessary by the Company in its good
faith and reasonable discretion. If the Employee is eligible for Severance Payments and the Additional Payments pursuant to Section 4.1, the Company will deliver the Release Agreement to the Employee within seven (7) calendar days
following the Termination Date. The Severance Payments and the Additional Payments are subject to the Employee’s execution of such Release Agreement within 45 days of the Employee’s receipt of the Release Agreement and the Employee’s non-revocation of such Release Agreement. 
 Section 4.5. Post-Termination Breach.
Notwithstanding anything to the contrary contained in this Agreement, the Company’s obligations to provide the Severance Payments and the Additional Payments will immediately cease if the Employee breaches any of the provisions of the Covenants
Agreement, the Release Agreement or any other agreement the Employee has with the Company. 
 Section 4.6. Removal from any Boards
and Position. If the Employee’s employment is terminated for any reason under this Agreement, upon notice of termination, he shall be deemed (without further action, deed or notice) to immediately resign (i) if a member, from the Board
or board of directors (or similar governing body) of any Affiliate of the Company or any other board to which he has been appointed or nominated by or on behalf of the Company and (ii) from all other positions with the Company or any subsidiary
or other Affiliate of the Company, including, but not limited to, as an officer of the Company and any of its subsidiaries or other Affiliates. 

  
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 ARTICLE 5 

GENERAL PROVISIONS 

Section 5.1. Company Non-Disclosure and Invention Assignment Agreement. The Employee
acknowledges and confirms that the Non-Disclosure and Invention Assignment Agreement executed by the Employee in favor of the Company in October, 2017 (“Covenants Agreement”), the terms of
which are incorporated herein by reference, remains in full force and effect and binding upon the Employee. The Covenants Agreement shall survive the termination of this Agreement and the Employee’s employment by the Company for the applicable
period(s) set forth therein. 
 Section 5.2. Expenses. Each of the Company and the Employee shall bear its/his own costs, fees
and expenses in connection with the negotiation, preparation and execution of this Agreement. 
 Section 5.3. Entire Agreement.
This Agreement and the Covenants Agreement contain the entire agreement of the parties hereto with respect to the terms and conditions of the Employee’s employment during the Term and activities following termination of this Agreement and the
Employee’s employment with the Company and supersede any and all prior agreements and understandings, whether written or oral, between the parties hereto with respect to the subject matter of this Agreement or the Covenants Agreement, including
without limitation the Prior Employment Agreement. Each party hereto acknowledges that no representations, inducements, promises or agreements, whether oral or in writing, have been made by any party, or on behalf of any party, which are not
embodied herein or in the Covenants Agreement. The Employee acknowledges and agrees that the Company has fully satisfied, and has no further, obligations to the Employee arising under, or relating to, any other employment or consulting arrangement
or understanding (including, without limitation, any claims for compensation or benefits of any kind) or otherwise. No agreement, promise or statement not contained in this Agreement or the Covenants Agreement shall be valid and binding, unless
agreed to in writing and signed by the parties sought to be bound thereby. 
 Section 5.4. No Other Contracts. The Employee
represents and warrants to the Company that neither the execution and delivery of this Agreement by the Employee nor the performance by the Employee of the Employee’s obligations hereunder, shall constitute a default under or a breach of the
terms of any other agreement, contract or other arrangement, whether written or oral, to which the Employee is a party or by which the Employee is bound, nor shall the execution and delivery of this Agreement by the Employee nor the performance by
the Employee of his duties and obligations hereunder give rise to any claim or charge against either the Employee, the Company or any Affiliate, based upon any other contract or other arrangement, whether written or oral, to which the Employee is a
party or by which the Employee is bound. The Employee further represents and warrants to the Company that he is not a party to or subject to any restrictive covenants, legal restrictions or other agreement, contract or arrangement, whether written
or oral, in favor of any entity or person which would in any way preclude, inhibit, impair or limit the Employee’s ability to perform his obligations under this Agreement or the Covenants Agreement, including, but not limited to, non-competition agreements, non-solicitation agreements or confidentiality agreements. The Employee shall defend, indemnify and hold the Company harmless from and against all
claims, actions, losses, liabilities, damages, costs and expenses (including reasonable attorney’s fees and amounts paid in settlement in good faith) arising from or relating to any breach of the representations and warranties made by the
Employee in this Section 5.4. 

  
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 Section 5.5. Notices. Any notice or other communication required or permitted
hereunder shall be in writing and shall be delivered personally or sent by nationally recognized overnight courier service (with next business day delivery requested). Any such notice or communication shall be deemed given and effective, in the case
of personal delivery, upon receipt by the other party, and in the case of a courier service, upon the next business day, after dispatch of the notice or communication. Any such notice or communication shall be addressed as follows: 

If to the Company, to: 

Adgero Biopharmaceuticals Holdings, Inc. 

4365 US Route 1 South 
 Suite
211 
 Princeton, NJ 08540 

Attn: Board of Directors 

With a copy to: 

Lowenstein Sandler LLP 
 1251
Avenue of the Americas 
 New York, New York 10020 

Attn: Michael J. Lerner, Esq. 

If to the Employee, to: 

John Liatos 
  


                                         
            
 
                                        
             
 With a copy to: 

 
 
                                         
            
 
                                        
             
 Any person named above may designate another address or fax number by
giving notice in accordance with this Section to the other persons named above. 
 Section 5.6. Governing Law; Jurisdiction.
This Agreement shall be governed by, and construed in accordance with, the laws of the State of New Jersey, without regard to principles of conflicts of law. Any and all actions arising out of this Agreement or Employee’s employment by Company
or termination therefrom shall be brought and heard in the state and federal courts of the State of New Jersey and the parties hereto hereby irrevocably submit to the exclusive jurisdiction of any such courts. THE COMPANY AND THE EMPLOYEE HEREBY
WAIVE THEIR RESPECTIVE RIGHT TO TRIAL BY JURY IN ANY ACTION CONCERNING THIS AGREEMENT OR ANY AND ALL MATTERS ARISING DIRECTLY OR INDIRECTLY HEREFROM AND REPRESENT THAT THEY HAVE CONSULTED WITH COUNSEL OF THEIR CHOICE OR HAVE CHOSEN VOLUNTARILY NOT
TO DO SO SPECIFICALLY WITH RESPECT TO THIS WAIVER. 

  
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 Section 5.7. Waiver. Either party hereto may waive compliance by the other party
with any provision of this Agreement. The failure of a party to insist on strict adherence to any term of this Agreement on any occasion shall not be considered a waiver or deprive that party of the right thereafter to insist upon strict adherence
to that term or any other term of this Agreement. No waiver of any provision shall be construed as a waiver of any other provision. Any waiver must be in writing. 

Section 5.8. Severability. If any one or more of the terms, provisions, covenants and restrictions of this Agreement shall be
determined by a court of competent jurisdiction to be invalid, void or unenforceable, the remainder of the terms, provisions, covenants and restrictions of this Agreement shall remain in full force and effect and shall in no way be affected,
impaired or invalidated and the parties will attempt to agree upon a valid and enforceable provision which shall be a reasonable substitute for such invalid and unenforceable provision in light of the tenor of this Agreement, and, upon so agreeing,
shall incorporate such substitute provision in this Agreement. In addition, if any one or more of the provisions contained in this Agreement shall for any reason be determined by a court of competent jurisdiction to be excessively broad as to
duration, geographical scope, activity or subject, it shall be construed, by limiting or reducing it, so as to be enforceable to the extent compatible with then applicable law. 

Section 5.9. Counterparts. This Agreement may be executed in any number of counterparts and each such duplicate counterpart shall
constitute an original, any one of which may be introduced in evidence or used for any other purpose without the production of its duplicate counterpart. Moreover, notwithstanding that any of the parties did not execute the same counterpart, each
counterpart shall be deemed for all purposes to be an original, and all such counterparts shall constitute one and the same instrument, binding on all of the parties hereto. 

Section 5.10. Advice of Counsel. This Agreement was prepared by Lowenstein Sandler LLP in its capacity as legal counsel to the
Company. Both parties hereto acknowledge that they have had the opportunity to seek and obtain the advice of counsel before entering into this Agreement and have done so to the extent desired, and have fully read the Agreement and understand the
meaning and import of all the terms hereof. Not in limitation of the foregoing, the Employee acknowledges that he has consulted with his counsel and/or tax advisors (or has knowingly elected not to do so) with respect to this Agreement, the amended
and restated terms hereof, and his options to purchase the Company’s common stock (and any changes thereto effected hereby, including without limitation the consequences of extending the post-termination exercise period of incentive stock
options). The Employee acknowledges that he is not relying on the Company or its counsel for any tax advice. 
 Section 5.11.
Assignment. This Agreement shall inure to the benefit of the Company and its successors and assigns (including, without limitation, the purchaser of all or substantially all of its assets) and shall be binding upon the Company and its
successors and assigns. This Agreement is personal to the Employee, and the Employee shall not assign or delegate his rights or duties under this Agreement, and any such assignment or delegation shall be null and void. 

  
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 Section 5.12. Agreement to Take Actions. Each party to this Agreement shall
execute and deliver such documents, certificates, agreements and other instruments, and shall take all other actions, as may be reasonably necessary or desirable in order to perform their or its obligations under this Agreement. 

Section 5.13. No Attachment. Except as required by law, no right to receive payments under this Agreement shall be subject to
anticipation, commutation, alienation, sale, assignment, encumbrance, charge, pledge, or hypothecation or to execution, attachment, levy or similar process or assignment by operation of law, and any attempt, voluntary or involuntary, to effect any
such action shall be null, void and of no effect; provided, however, that nothing in this Section 5.13 shall preclude the assumption of such rights by executors, administrators or other legal
representatives of the Employee or the Employee’s estate and their assigning any rights hereunder to the person or persons entitled thereto. 

Section 5.14. Source of Payment. Except as otherwise provided under the terms of any applicable employee benefit plan, all
payments provided for under this Agreement shall be paid in cash from the general funds of Company. The Company shall not be required to establish a special or separate fund or other segregation of assets to assure such payments, and, if the Company
shall make any investments to aid it in meeting its obligations hereunder, the Employee shall have no right, title or interest whatever in or to any such investments except as may otherwise be expressly provided in a separate written instrument
relating to such investments. Nothing contained in this Agreement, and no action taken pursuant to its provisions, shall create or be construed to create a trust of any kind, or a fiduciary relationship, between the Company and the Employee or any
other person. To the extent that any person acquires a right to receive payments from the Company hereunder, such right, without prejudice to rights which employees may have, shall be no greater than the right of an unsecured creditor of the
Company. The Employee shall not look to the owners of the Company for the satisfaction of any obligations of the Company under this Agreement. 

Section 5.15. Tax Withholding. The Company or other payor is authorized to withhold from any benefit provided or payment due
hereunder, the amount of withholding taxes due any federal, state or local authority in respect of such benefit or payment and to take such other action as may be necessary in the opinion of the Board to satisfy all obligations for the payment of
such withholding taxes. The Employee will be solely responsible for all taxes assessed against his with respect to the compensation and benefits described in this Agreement, other than typical employer-paid taxes such as FICA, and the Company makes
no representations as to the tax treatment of such compensation and benefits. 
 Section 5.16. 409A Compliance. All payments
under this Agreement are intended to comply with or be exempt from the requirements of Section 409A of the Code and regulations promulgated thereunder (“Section 409A”). As used in this Agreement, the
“Code” means the Internal Revenue Code of 1986, as amended. To the extent permitted under applicable regulations and/or other guidance of general applicability issued pursuant to Section 409A, the Company reserves the right to
modify this Agreement to conform with any or all relevant provisions regarding compensation and/or benefits so that such compensation and benefits are exempt from the provisions of 409A and/or otherwise comply with such provisions so as to avoid the
tax consequences set forth in Section 409A and to assure that no payment or benefit 

  
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shall be subject to an “additional tax” under Section 409A. To the extent that any provision in this Agreement is ambiguous as to its compliance with Section 409A, or to the
extent any provision in this Agreement must be modified to comply with Section 409A, such provision shall be read in such a manner so that no payment due to the Employee shall be subject to an “additional tax” within the meaning of
Section 409A(a)(1)(B) of the Code. If necessary to comply with the restriction in Section 409A(a)(2)(B) of the Code concerning payments to “specified employees,” any payment on account of the Employee’s separation from
service that would otherwise be due hereunder within six (6) months after such separation shall be delayed until the first business day of the seventh month following the Termination Date and the first such payment shall include the cumulative
amount of any payments (without interest) that would have been paid prior to such date if not for such restriction. Each payment in a series of payments hereunder shall be deemed to be a separate payment for purposes of Section 409A. In no
event may the Employee, directly or indirectly, designate the calendar year of payment. All reimbursements provided under this Agreement shall be made or provided in accordance with the requirements of Section 409A, including, where applicable,
the requirement that (i) any reimbursement is for expenses incurred during the Employee’s lifetime (or during a shorter period of time specified in this Agreement), (ii) the amount of expenses eligible for reimbursement during a calendar
year may not affect the expenses eligible for reimbursement in any other calendar year, (iii) the reimbursement of an eligible expense will be made on or before the last day of the calendar year following the year in which the expense is
incurred, and (iv) the right to reimbursement is not subject to liquidation or exchange for another benefit. Notwithstanding anything contained herein to the contrary, the Employee shall not be considered to have terminated employment with the
Company for purposes of Section 4.1 unless the Employee would be considered to have incurred a “termination of employment” from the Company within the meaning of Treasury Regulation
§1.409A-1(h)(1)(ii). In no event whatsoever shall the Company be liable for any additional tax, interest or penalty that may be imposed on the Employee by Section 409A or damages for failing to
comply with Section 409A. 
 Section 5.17. 280G Modified Cutback. 

(a) If any payment, benefit or distribution of any type to or for the benefit of the Employee, whether paid or payable, provided or to be
provided, or distributed or distributable pursuant to the terms of this Agreement or otherwise (collectively, the “Parachute Payments”) would subject the Employee to the excise tax imposed under Section 4999 of the Code (the
“Excise Tax”), the Parachute Payments shall be reduced so that the maximum amount of the Parachute Payments (after reduction) shall be one dollar ($1.00) less than the amount which would cause the Parachute Payments to be subject to
the Excise Tax; provided that the Parachute Payments shall only be reduced to the extent the after-tax value of amounts received by the Employee after application of the above reduction would exceed the after-tax value of the amounts received without application of such reduction. For this purpose, the after-tax value of an amount shall be determined taking into account all
federal, state, and local income, employment and excise taxes applicable to such amount. Unless the Employee shall have given prior written notice to the Company to effectuate a reduction in the Parachute Payments if such a reduction is required,
which notice shall be consistent with the requirements of Section 409A to avoid the imputation of any tax, penalty or interest thereunder, then the Company shall reduce or eliminate the Parachute Payments by first reducing or eliminating any
cash payments (with the payments to be made furthest in the future being reduced first), then by reducing or eliminating 

  
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accelerated vesting of stock options or similar awards, and then by reducing or eliminating any other remaining Parachute Payments; provided, that no such reduction or elimination shall apply to
any non-qualified deferred compensation amounts (within the meaning of Section 409A) to the extent such reduction or elimination would accelerate or defer the timing of such payment in manner that does
not comply with Section 409A. 
 (b) An initial determination as to whether (x) any of the Parachute Payments received by the
Employee in connection with the occurrence of a change in the ownership or control of the Company or in the ownership of a substantial portion of the assets of the Company shall be subject to the Excise Tax, and (y) the amount of any reduction,
if any, that may be required pursuant to the previous paragraph, shall be made by an independent accounting firm selected by the Company (the “Accounting Firm”) prior to the consummation of such change in the ownership or effective
control of the Company or in the ownership of a substantial portion of the assets of the Company. The Employee shall be furnished with notice of all determinations made as to the Excise Tax payable with respect to the Employee’s Parachute
Payments, together with the related calculations of the Accounting Firm, promptly after such determinations and calculations have been received by the Company. 

(c) For purposes of this Section 5.17, (i) no portion of the Parachute Payments the receipt or enjoyment of which
the Employee shall have effectively waived in writing prior to the date of payment of the Parachute Payments shall be taken into account; (ii) no portion of the Parachute Payments shall be taken into account which in the opinion of the
Accounting Firm does not constitute a “parachute payment” within the meaning of Section 280G(b)(2) of the Code; (iii) the Parachute Payments shall be reduced only to the extent necessary so that the Parachute Payments (other than
those referred to in the immediately preceding clause (i) or (ii)) in their entirety constitute reasonable compensation for services actually rendered within the meaning of Section 280G(b)(4) of the Code or are otherwise not subject to
disallowance as deductions, in the opinion of the auditor or tax counsel referred to in such clause (ii); and (iv) the value of any non-cash benefit or any deferred payment or benefit included in the
Parachute Payments shall be determined by the Company’s independent auditors based on Sections 280G and 4999 of the Code and the regulations for applying those sections of the Code, or on substantial authority within the meaning of
Section 6662 of the Code. 
 Section 5.18. Recoupment of Erroneously Awarded Compensation. Any incentive-based or other
compensation paid to the Employee under this Agreement or any other agreement or arrangement with the Company which is subject to recovery under any law, government regulation, stock exchange listing requirement or any clawback policy adopted by the
Company from time to time will be subject to the deductions and clawback as may be required by such law, government regulation, stock exchange listing requirement or clawback policy. In addition, if the Employee is or becomes an executive
officer subject to the incentive compensation repayment requirements of the Dodd-Frank Wall Street Reform and Consumer Protection Act (the “Dodd-Frank Act”), then if required by the Dodd-Frank Act or any of its regulations he will
enter into an amendment to this Agreement or a separate written agreement with the Company to comply with the Dodd-Frank Act and any of its regulations. 

  
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 Section 5.19. Certain Definitions. As used in this Agreement, “Change in
Control” means (x) a change in ownership of the Company under clause (i) below or (y) a change in the ownership of a substantial portion of the assets of the Company under clause (ii) below: 

(i) Change in the Ownership of the Company. A change in the ownership of the Company shall occur on the date that any
one person, or more than one person acting as a group (as defined in clause (iii) below), acquires ownership of capital stock of the Company that, together with capital stock held by such person or group, constitutes more than 50 percent
of the total fair market value or total voting power of the capital stock of the Company. However, if any one person or more than one person acting as a group, is considered to own more than 50 percent of the total fair market value or total
voting power of the capital stock of the Company, the acquisition of additional capital stock by the same person or persons shall not be considered to be a change in the ownership of the Company. An increase in the percentage of capital stock owned
by any one person, or persons acting as a group, as a result of a transaction in which the Company acquires capital stock in the Company in exchange for property will be treated as an acquisition of stock for purposes of this paragraph. 

(ii) Change in the Ownership of a Substantial Portion of the Company’s Assets. A change in the ownership of a
substantial portion of the Company’s assets shall occur on the date that any one person, or more than one person acting as a group (as defined in clause (iii) below), acquires (or has acquired during the
12-month period ending on the date of the most recent acquisition by such person or persons) assets from the Company that have a total gross fair market value equal to or more than 80 percent of the total
gross fair market value of all of the assets of the Company immediately prior to such acquisition or acquisitions. For this purpose, gross fair market value means the value of the assets of the Company, or the value of the assets being disposed of,
determined without regard to any liabilities associated with such assets. There is no Change in Control under this clause (ii) when there is a transfer to an entity that is controlled by the shareholders of the Company immediately after the
transfer, as provided below in this clause (ii). A transfer of assets by the Company is not treated as a change in the ownership of such assets if the assets are transferred to (a) a shareholder of the Company (immediately before the asset
transfer) in exchange for or with respect to its capital stock, (b) an entity, 50 percent or more of the total value or voting power of which is owned, directly or indirectly, by the Company, (c) a person, or more than one person
acting as a group, that owns, directly or indirectly, 50 percent or more of the total value or voting power of all the outstanding capital stock of the Company, or (d) an entity, at least 50 percent of the total value or voting power
of which is owned, directly or indirectly, by a person described in clause (ii)(c) of this paragraph. For purposes of this clause (ii), a person’s status is determined immediately after the transfer of the assets. 

(iii) Persons Acting as a Group. For purposes of clauses (i) and (ii) above, persons will not be considered to be
acting as a group solely because they purchase or own capital stock or purchase assets of the Company at the same time. However, persons will be considered to be acting as a group if they are owners of a corporation that enters into a merger,
consolidation, purchase or acquisition of assets or capital stock, or similar business transaction with the Company. If a person, including an entity, owns stock in 

  
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both corporations that enter into a merger, consolidation, purchase or acquisition of assets or capital stock, or similar transaction, such shareholder is considered to be acting as a group with
other shareholders in a corporation only with respect to the ownership in that corporation before the transaction giving rise to the change and not with respect to the ownership interest in the other corporation. For purposes of this paragraph, the
term “corporation” shall have the meaning assigned such term under Treasury Regulation section 1.280G-1, Q&A-45. 

(iv) Each of clauses (i) through (iii) above shall be construed and interpreted consistent with the requirements of
Section 409A and any Treasury Regulations or other guidance issued thereunder. 
 [Signature Page Follows] 

  
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 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the day and
year first above written. 
  

			
	COMPANY
	
	 ADGERO BIOPHARMACEUTICALS
 HOLDINGS,
INC.

		
	By:	 	 /s/ Laura Edgerly Pflug

	Name:	 	Laura Edgerly Pflug
	Title:	 	VP Technical Operations
	
	EMPLOYEE
	
	 /s/ John Liatos

	John Liatos


 [SIGNATURE PAGE TO EMPLOYMENT
AGREEMENT]