Thiram Dietary Exposure and Ri sk Assessment DP# 427382 

### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 Office of Chemical Safety and Pollution Prevention

MEM ORAND UM D ATE: 21-May-2015 

### SU BJECT : T hiram : Revised Ac ute and Chronic Dietary (Food and Drinking Water) Exposure and Risk Assessme n t to Support a Pet it ion for the Conversion of the Time-L im i ted B anana To lerance to Permane nt a nd Im po rt use on Avocado. P C Code: 07980 I Dec isio n No.: 488085 Pe ti t io n No.: 4E8250 Ri s k Assess m e nt T y p e: Dietary TXR No.: NA M RJD No.: NA F RO M : Thurston 

### G. Morton, Chemist Risk Assessme n t B ranc h IV H ealth Effects D ivision (7509 P) DP No
. : 0427382 R eg istr atio n No . : NA R eg ul atory Ac tio n: Tolerance , no registration Case No.: 0122 CAS No.: 137-26-8 4 0C FR: § 180.13 2

# <7d**l'JA~c**

T HRO UG H: Doug Dotson , PhD. ,

## Senio**C** emist 

# 4-.**/)~** Kristin Rury , Biologist 

# i**,../~** 

# .**~** Dietary Exposure Science dviso ro/' Council (MSAC ) Health Effects Division (7509P) And Charles Smith , Branch Chief

## C-**~** Risk Assessment Branch IV Health Effects Division (7509P) TO : Dris s Benmhenol Rachel Holloman , Branch Chief R egistration Division (7505P)
Revised th iram acute and chronic dietary (food and d rinki ng wate r) exposu re assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commod i ty Intake Database D EEM- FC I DTM , Ve rsion 3.16. This software uses 2003-2008 food consumption data from the U.S. Department of Agricu lture ' s (USDA ' s) Nat ional Health and Nutrition Exam ination Survey , What We Eat in America, (NHANES / WWEIA). The anal yses were performed to evaluate the proposed new u se of avocado and convers i on of the time-limited tolerance on banana s to a permanent tolerance.
Page I of 15Thi ram Die tary Exposure and Risk Assessment DP# 42 7 382 

### This me mo randum w as rev iewe d b y two peer r ev iewers of th e DESAC, per DESAC S tand ard Op eratin g Pro cedure (S OP ) 2 01 2 .1. Acute Dietary (Foo d and Drinking Water) Expos ure Results and C haracteri z at io n A partially refined probabilistic ac ute d ietary
- expos ure assessment was performed using 1 00 percent c rop treated (%CT), ave rage field trial residues or pu lp res idu es for blended commodities, d i stributions of field trial res idu es , highe st pulp re s idue , and e mpirical proce ss in g factors. Di etary ri s k esti mates were determin e d cons idering ex pos ure s from food and drinkin g wate r u si n g est i mated drinking water conce ntrati on s (EDW Cs) for surface wat e r sourc es provided by th e Environmental Fat e and E ffects Divis ion (EFE O ). The acute dietary ri sk est im at es for food and drinking water co mbine d are be low H ED 's leve l of concern ( i. e., < 100 % of th e a PAD of 0.6494 mg/ kg bw / day) fo r the ge ne ral U. S. population and all population s ubgroup s ( including fe mal es 13 -49 years o ld ; aPAD of 0.014 m g/kg b w/ day). Using D EEM-FC ID , acute dietary exposure at the 95th exposure percentile is est im ated at 0.012002 mg/kg bw / day for the ge neral U.S. population ( 1.9 % of the aPAD ) and 0.008595 m g/kg bw / day (61 % of the a PAD) fo r females 13-4 9 years old , the population subgro up w ith the highest percent aP A O
. Chronic Di etary (Food and Drinking Water) Ex po s ure R es ul ts and Characteri zati on A partiall y refined c hron ic dietary

- exposure assessme nt was performed using tolerances , average field trial re s idues , highest pulp residue for avocado , the proposed banana tolerance , and e mpirica l processing factors. Di etary ri sk estim ates were determined considering exposures from food and drink in g water u s in g EDW Cs fo r s urface water so urces provid e d by EFED. The re s ultin g chro n ic dietary risk es timates for food and drinkin g water are bel ow H ED 's level of concern ( i .e. , < 1 00% of the chro nic population adjusted dose ; c P A D of 0.015 mg/kg bw / day) for the general U .S
. popu l at ion and all population subgroups. Using D EEM

- FCID , di etary expo s ure is esti m ated at 0 .00 1 999 mg/kg bw / day for th e general U
. S. popu l ation ( 13 % of the c P AD) and 0.010557 m g/kg bw/ day (70% of the c P AD) for c hildre n 1- 2 years old , the population s ub gro up with th e hi g hes t es timate d c hroni c dietary ex pos ure to thiram. I. 

### INTRODUCTION Di etary ris k assessment incorporates both exposur e and toxicity of a g i ven pes ti cide. For acute and chro ni c assess m e n ts , the ri sk is ex pressed as a percentage of a maximum acce ptable dose (i.e
. , the dose that HED has concluded wi ll resu lt in no unreaso nable adverse health effects). Thi s d ose is referred to as th e PAO. The P AD is equi va le nt to po int of depa rture (POD , NOAEL , LOAEL , e.g. ) d ivided by the required uncertainty or safety factor s . Fo r ac u te and non-cancer chronic exposures , HED i s concerned w he n estimated dietary risk exceeds I 00% of the P AO. References that discuss the ac ute and c hronic risk assess men ts in more d e ta i I are ava il able o n th e EP A/ p es ticid es web site: " Ava il a ble Inform a tion on Assessing Ex po s ure from P esti c ides , A Use r' s Guide ," 2 l-JUN

- 2000 , web link: http :// www.epa.gov/fedrg s tr /E P A -PEST / 2000/Jul y/Day-12/ 606 I 

### .pdf; or see SO P 99.6 (20

- AUG-1999 )
. Th e mo s t recent dietary ri sk assessment for thiram was co ndu cted 

### by T. Morton ( 04 23339 , 2/ 24/ 14)
. Page 2 of 15Thi ram Dietary Exposure and Risk Assessment DP# 427382


### II. RESIDUE INFORMATION Residue Data used for Acute and Chronic Assessments Established Tolerances: Tolerances for residues in/on food and feed commodities are currently expressed in te rm s ofresidues of thiram (tetramethyl thiuram disulfide) [40CFR§180
. 132] are establi shed at 7 .0 ppm for apples, strawberries, and peaches. A time-limited import tolerance is also estab li shed for thiram on bananas at 0.80 ppm. Thiram is also the residue of concern in plants for dietary risk assessment purposes. Acute Anticipated Residues For the probabilistic acute dietary-exposure analysis, the entire distribution of field-trial data was used to generate residue-distribution files (RDFs) for commodities that are not considered blended or partially blended (see Table 2). For commodities that were cons idered blended (i.e. dried app le , dried banana, and dried peach) , point-estimates consisting of the ave rage field-trial residue were used
. Empirical processing factors were also used. In add ition , the assessment assumed 100% of the crops were treated with thiram. Chronic Anticipated Residues Avocado pulp residues, and average field trial residues for apples, bananas (pulp) , peaches and strawberries along with l 00% crop treated were used for the chronic dietary exposure analysis for a ll crops. Empirical processing factors were also used. The USDA Pesticide Data Program (PD P) monitored pesticide residues in catfish in 2008, 2009 , and 2010. PDP did not analyze catfish samp les for thiram residues. As a result , residues in fish were not included in the assessment. 

### Processing Factors Processing factors were obtained from strawberry was hin g and apple processing studies submitted to the Agency by the registrant (F. Fort, D283996, 04/ 20/ 03)
. The strawberry washing factor was used for strawberries only. The apple washing factor was used for peaches and apples. The apple drying facto r was used for apples , peaches , and bananas. The app le sauce factor was used for apple sauce, peach babyfood , and strawberry babyfood. Finall y, the apple juice factor was used fo r apple, peaches, and strawberries. The table below shows the resu lts of these studies and the processing factors that were used to refine the acute a nd chroni c assessments
.

Tab l e I. Processing Factors. Type Factor Consumer practice (strawberry) 0.42 Washing (apple) 0
.79 Drying (apple) 2.4 used for all dried commod ities Sauce (apple) 0.18 used also for baby food commodities Juice (apple) 0.12 Page 3of15Thiram Diet ary Exposure and Ri sk Assessment DP# 427382


### Percent C rop Tre ate d Inform ati on P ercent c rop treated was se t a t 100 % for th e acute and chronic dietary exposure analyses.
Tab le 2. S umm a r y of Anticipated R esid ues for T hir am . Percent C r oo Treated 3 Res idu e Di s tribution fo r C hronic Data Process in g We i ghted Es timated Acu te An ti c ipated An ti cipated Co mm od i ty C lass ification 1 Used 2 Factor Avg. Max Residue Res idu e, ppm Avocado NB / PB FT I 100 100 0.05 hi g hest pulp re sidue 0.05 Apple. fruit with peel B / PB FT 0.79 100 100 RDF # I 3.7

Apple. peeled fruit Apples 'Apples 'lOOt Ct TOTAL Z=O TOTALNZ=20 0.95, 2. 09, 0
. 91, 1.41, 4.22, 0
. 86, 8.65, 5.18, 6.75, 4.56. 2.93, 3.98, 4.24, 4. 69, 5
. 60, 5.97, 6.53, 1
. 62, 1
. 72, 1.72 App l e, peeled fruit- PB FT 0.79 100 100 RDF # I 3.7 baby food Apple. dried B FT 2.4 100 100 3.72 average of field 3.7 Apple. dried-babyfood trial s App l e, juice PB FT 0. 12 100 1 00 RDF # I 3.7 Apple, juicc-babyfood App l e. s auce PB FT 0. 18 1 00 100 RDF # I 3.7 Apple, saucc-babyfood Peach NB/PB FT 0.79 1 00 100 RDF #2 3.2 'Peaches 100%CT TOTA.L Z = IOO TOTA LNZ=2 1 3.29. 6.42. 3.04. 3.47 4
. 54. 5.93. 2. 19. 2.61 2.98. 1.47. 1.90, 3. 17 2.49. 1. 90. 3. 10, 3.37 5.38. 3.95. 2.24. 1. 73 1. 9 1 Peach. babyfood PB F T 0. 1 8 100 100 RDF #2 3.2 Peach. dried B FT 2.4 100 100 3.26 average of field 3.2 Peach. dried

- babyfood trial s P

each. juice PB FT 0. 1 2 100 100 RDF #2 3.2 Peach, juice

- babyfood S tra wberry PO FT 0.42 100 100 RDF #3 New Data : 4.9 'Strawber ri es
' 1

00%CT TOTA.L Z=O TOTALNZ= IO 3.45. 3. 15. 4 .30
. 0.05 4, 11 .4. 5.40. 5
. 3, 4
. 2
Page 4of15Thiram Dietary Exposure and Risk Assessment DP# 427382 T ab l e 2. S umm a ry o f A nticip a t e d R es idu es for T hi ra m. Percent Croo Treated 3 Residue Di st ribution for Chronic Data Processing Weighted Estimated Acute Anticipated Anticipated Commodity Classification 1 Used 2 Factor Avg. Max Residue R esidue, ppm 7 .65 Strawber r y - babyfood PB FT 0.18 100 100 RDF #3 4
. 9 Strawberry - juice PB FT 0.12 100 100 RDF #3 4.9 Strawberry, juice

- babyfood Banana, peeled fruit NB / PB FT 1.0 100 100 Bananas ( pu lp) 0.119 Banana , peeled fruitbabyfood Banana, dried B FT Banana, dricd -babyfood 1 NB= Non -bl ended; PB = partially blended ; B = blended. 2 FT= field -tri al data 

### Il l. Drinkin g Water D a t a 2.4 0.276 max resid ue average used pulp re s idu e 100 100 0. 1 19 0. 119



### The current action will n ot affect t he EDWCs , therefore, the previous drinking water assessment (J. Carleton and F . J enk ins , 12111/03) is still app licable. Because monitoring data are unavailab l e , estimates of th iram concentrations were made onl y w i th mathemati cal mode l s . EDWC values were generated by the PRZM (Pesticide Root Zone Model)-EXAMS (Exposure Analys i s Modeling System) for the turf application scenar i o , s i nce th is scenar i o y i el ded th e highest EDWC values
. Ground water sources were not included , as the EDWCs for th is water so urce are minimal in comparison to those for surface water. Water res i d ues (surface water E DWC of 0.0478 ppm for acute and 0.0025 ppm for chronic) were incorporated in DEEM

- FC ID into the food categories "water, direct, all sources" and " water , indirect, all sources" for the dietary assessments.
Ta b l e 3. E DW Cs for Use i n th e Hum a n - H ea lth Ri s k Assess m e nt. An n u a l App R ate SC I G ROW P RZ M / E X A M S* PRZ M /E X A M S* ( l b s co n ce n tratio n Ac ut e E DW C n o n - c a n ce r c hron ic Cro p ai/ac r e/ v r) (nnb) (nn b) E DW C <oob) Turf farm 146.6 0.84 47.8 2 .5 

### * Inde x Re se rvoir environment 

### IV. D EEM

- FC JDTM PRO G RAM AN D C O NSUM P T ION I NF ORMA TIO N Thiram acute and chronic dietary exposure assessments we re conducted using the D EEM-FCID, Version 3.16. Thi s software uses 2003-2008 food consumption data from the U.S
. D epartment of Agriculture 's (USDA ' s) National Health and Nutrition Exam ination Survey , What We Eat in America, (NHANES/WWEIA). The data are bas e d on the reported consumption of more than 20,000 ind ividuals over two non
- con secutiv e survey days
. Foods "as consumed" (e.g., app le pie) are linked to EPA-defined food commodities (e
. g. apples , peeled fruit

- cooked; fre s h or N/ S; baked ; or wheat fl our - cooked; fresh or N/ S , baked) using pub li cly availab le recipe tran s lation files developed jointly by US D A/ARS and E PA. For chronic exposure assessm e nt , co nsumption data are averaged for the entire U .S
. popu lat ion and within popu l ation subgro u ps , but for ac u te exposure assessment are retained as individua l consumpt ion events
. Based on analysis of the 20 03-2008 WWEIA consumption data , which took into account dietary patterns and survey Page 5o f15Thi ram Dietary Exposure and Risk Assessment DP# 427382 

### respond e n ts, HED concluded that it is most appropriate to report risk for the followi ng population s ubgroups: th e ge neral U.S. population , all infant s ( < l year old), c hildren 1-2 , children 3-5, children 6-12, yo uth 13-19, adults 2 0-49 , females 1 3 -49 , and adults 50-99 years old. For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue li st i s multip lied by the average dai ly consumption estimate for that food/ food form to produce a r es idu e intake est im ate. The re su ltin g res idue intake es timate for each food/ food form is summed with the residue intake estimates fo r all other food/food forms on the commodity residue li st to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body we ig ht/day and as a percent of the cPAD. This procedure is performed for eac h population subgroup. For acute expos ure assessments , individual one-day food co n s umption data are u se d on an indi v idual -by -individu a l basis. T he reported consu mption amount s of each food item can be multiplied by a residue point estimate and s umme d to obtain a total d a il y pesticide exposure for a determini s tic exposure assessme nt , or " matched " in multiple random pairings with residue values and then summed in a probabi li stic assessment. The resulting distribution of exposures is expressed as a percentage of th e aPAD on both a user ( i .e., on ly those who repo rted eatin g relevant commodities/food forms) and a per-capita (i.e., those who reported eatin g the rel evant commodities as we ll as those who did not ) basis. In accordance with HED policy , per capita expos ure and risk are reported for all tiers of anal ysis. However , for tiers l and 2, any significant differences in user vs. per capita exposure and risk are specificall y identified and noted in the risk assessment. 

### V. TOXICOLOGICAL INFORMATION A summary of the toxicological endpoints and doses chosen for the relevant exposure scenarios for human risk assessment are found in Table 4.

Page 6of15Thi ram Dietary Exposure and Risk Assessment DP# 427382 Table 4. S umm a rv ofToxico l o!!ica l Do ses a nd E ndo o int s for Thiram for Use in Dietarv Risk A ssess ments. RID , PAD , Exposure/ Point o f Uncertainty/FQPA LOC for Ri s k Sce n a rio D e parture Safetv F a c tors Assessment St ud v and Toxic o lo!!i ca l E ff ec t s Acute Dietary BMDL1 0 = UFA = I Ox Acute RID = Acute Neurotox icity S tud y - Rat (General 64.94 UFH = I Ox 0.6494 LOAEL = 150 mg/kg/day based on Population) mg/kg/day FQPA SF = I x mg/kg/day FOB effects (lethargy, lower temperature , reduced startle aPAD = 0.6494 response , no tai l pinch response), mg/kg/day reduced motor activity, and red uc ed brain weights. Acute Dietary NOA EL = 1. 4 UFA = I Ox Acute RID = Dev. Neurotoxicity Study

- Rat (Fema les 13- mg/kg/day UFH = IOx 0.014 LOAEL = 3.7 mg/kg/day based on 49 years old) FQPA SF = I x mg/kg/day increases in motor activity seen in female offspring on PND 17 aPAD = 0.014 mg/kg/day Chronic NOAEL = 1.5 UFA = IOx Chronic RID = Comb in ed Chronic Dietary mg/kg/day UFH = I Ox 0.015 Toxic ity/ Carcinogenicity Stud y - (All FQPA SF = Ix mg/kg/day Rat & Chronic Oral Toxicity Study populations)

- Dog cPAD =0.015 LOAEL = 7.3 mg/kg/day based on mg/kg/day changes in hematology, c l inical che mi stry, in cide nces of b il e duct hyperp las ia, and reduction in mean body we ig ht ga in seen at 7 .9 mg/kg/day in conjunction with elevated cho lesterol levels and increased liver weights reported in the chronic oral toxicity study in dogs at 2.6 mg/kg/day Cance r (oral , dermal, " Not Likely to be Carcinogenic to Human s" inhalation) Pomt of Departure (POD) = A data pomt or an estimated pomt that 1 s derived from observed dose-response data and used to mark the beginning of extrapolation to determine risk associated w ith lower env ironmentally relevant human exposures. NOAEL = no-observed adverse-effect level. LOA EL = lowe st-obse rv ed adverse-effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (intraspecies). UF1

- 1= potential variation in sensitivity among members of the human population ( interspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute , c = chronic). RID = reference dose.



### VI. RESULTS/DISCUSSION AND CONCLUSIONS As stated above, fo r acute and chronic assessments , HED is generally co ncerned when dietary risk exceeds 100 % of the PAO
. T he DEEM-FCID analyses estimate the dietary exposure of the general U.S. popu l ation and vario u s population subgroups. T he results reported in Tab les 5 and 6 are for the general U
. S. popu lati on, all infants (< I year o ld) , chi ldren 1- 2, ch il dren 3-5, children 6-12, youth 13-19 , fema les 1 3

- 49 , adults 20-49, and ad ult s 50-99 years old.

Page7ofl5Thiram Dietary Exposure and Risk Assessment DP# 427382 

### R esu lts of Ac ute Di etary-Ex posure Analy s is A parti a ll y refi ned probabili s tic acute d ietary-expos ure ass ess me nt was performed u s ing 100 %C T , average residue of fi e ld-trial residue va lu es for blended commodities , di stribution of field trial res idu es, highest pulp residues , and empirical proc ess in g facto rs. Di eta ry ri sk estimates were determ in ed considering exposures from food plus drinkin g water u s in g EDWCs for s urface water so urce s provided by EFED. Th e ac ute d i etary ri s k es timate s for food and drinking water co mbined are be low H ED 's level of concern ( i .e. , < 100 % of th e aPAD of0 .6 494 m g/kg bw/day) for the general U.S
. population and all populat ion s ubgroup s ( including fe ma les 1 3

- 49 years o ld ; a PAD of 0.014 mg/kg bw/d ay). Us in g D EEM- FCID , acute di e tary expo s ure a t the 95ih exposu r e percentile is es timated at 0.0 12002 mg/ kg bw/ day fo r th e ge nera l U.S
. population (l.9 % of the aP A D) and 0.008595 mg/kg bw / day (6 1% of the a P A D) for female s 13-49 years old , the popul at ion s ub gro up w ith th e hi g hes t % aPA D die tary expos ure to thiram. Th e es tim ated ex posures/risks for food and drinking water are summarized in Table 5. Tab l e 5. Re s ults of Acute Dietary Ex p osure and Risk Analys is for Thiram (Food + Water). 95•h Perce ntil e

P op ulation a PAD Exposure S ub g r o u p ( mg/ kg/ da y) (mg/kg/day) %aPAD General U .S. Population 0.6494 0.012002 1.9

- All I n fants

( < l year o ld ) 0.6494 0.0 27 109 4.2 C hildre n 1 -2 years o ld 0.6494 0.043503 6.7



### - 

# I Children 3-5 y ears old 0.6494 0.032302 5.0 >----

Children 6- 12 years o ld 0.6494 0.0186 67 2.9



## - Youth 1 3- 19 years o ld 0.6494 0 .00985 1 1.5 Adu lt s 20-49 year s old 0.6494 0.007907 1.2 Adu lt s 50

- 99 years o ld 0.6494 0.008705 1. 3



### - F e m a les 1 3

- 49 years o ld 0.0 14 0.008595 6 1 • The valu es for the h ighes t ri sk population for each percentile a r e bolded. 

### R

es ult s o f C hronic Di eta ry-Ex posure A nalys is The partially refined chronic dietary ri sk est imate s for food and water combined are below HED ' s leve l of concern ( i .e. , < 100 % of the cPAD of0.015 m g/kg bw/d ay) for the general U.S. population and a ll population subgroup s. Us in g the DEEM -FC TD softwa re , di etary exposure is esti m ated at 0.00 1999 mg/kg bw / day for th e ge ne ral U
. S. pop ul a tion (13% o f the c PAD ) a nd 0.0 10557 mg/kg bw/da y (70% of the cPAD) for children 1- 2 years o ld, the pop u lation s ub gro up with the hi g he s t estimat e d c hro nic di etary exposure to thiram. T he estimated exposures/risks fo r P

age 8of 1 5Thiram Dietary Exposure and Ri s k As s essment DP# 427382 

### food and drinkin g water are s ummarized in T ab le 6.

Table 6. Summary of C h ron i c Dietary Expos u re a n d Ri s k fo r T hi r am (Food + Water). Age Group c PAD ( mg/kg/day) Ex p osur e (mg/kg/day) %cPA D General U.S. Popul ati o n 0.0 1 5 0.001999 1 3 All In fants ( < I yea r old) 0.015 0.005387 36 C hildren 1-2 years old 0.0 15 0.0 1 0557 70 C hildren 3-5 years old 0.015 0.006870 46 C hildren 6

- 12 years old 0.015 0.003359 22 Youth 13-19 y ears old O.QIS 0.00 1413 9.4 Adult s 20-49 years old 0.0 1 5 0.001077 7.2 Adults 50-99 years o ld 0.015 0.00 1421 9.5 Females 1 3-49 years old 0
.01 5 0.001186 7.9 

### * The va lu es for the hi g hes t exposed population is bolded. 

### VII. DISCUSSION OF UNCERTAINTIES Residues in all foods were based on the results of field tri als. Field-tri a l res idu es sho uld exceed the residue levels fo und o n food co mmoditi es a t th e time of consumption. When field trial s are performed, the m ax imum a ll owab le app li cation rate is u sed and crops are harv este d at the minimum pre -h arvest inte r va l (PHI ). Samples are s tore d frozen until an a lysis to ensure minimal degradation of residues. Jn actua l practice , howeve r, growers will not u s u a ll y u se the maximum app li cation rates fo r eco nomic rea so ns . In add it ion, mo st crops are not harvested and imme diate ly s to red frozen. Fo r th ese reasons , H ED is co nfident that thi s a na lys i s doe s not underestimate risk to the ge ne ra l U.S
. population or any population subgr oup. 

### VIII. LIST OF ATTACHMENTS Attac hm e nt 1- Residue Input s for Acute Dietary Assessme nt of Thi ram Attac hme nt 2

- Re s ult s of Refi ne d Acute Di eta ry Ana lys i s for Thiram Attac hment 3- R es idu e Input s for Chronic Di eta r y Assessment of Thiram Attac hment 4

- Re s ult s of Partially Refined C hroni c Di etary Analy s i s for Thi ram

c c : T
. Morton ( RAB4 ) T. Morton:S I 0838:PY-S:(70 3) 305-669 l :7509P:RAB4

Page 9of 1 5Thi ram Di etary Ex po sure and Ri s k Assess ment DP# 427382 

### Attac hme nt 1- R es idue Input s for Acute Dietary As sess ment of Thi ram
Filename: C:\Users\tmo r ton\Oocuments\My Files\DEEM Files\079801 Thiram\Banana and Avocado Rerun\079801 Acute Food and Water.ROS Chemical : Thiram RfD(Chronic): .015 mg/kg bw /day NO EL(Ch ronic): O mg /kg bw/day RfD(Acute) : .6494 mg/kg bw /day NOEL(Acut e) : O mg /kg bw/day Date created/last modified: 12-16-2014/11:10:41 Program ver. 3.16, 03-08-d RDL indices and parameters for Monte Carlo Analysis: Index Dist Parameter #1 Param #2 Param #3 Comment

# Code

_____ 

### .. _____ _

-- ------ 

### ----- - -- 

### - ------ 1 6 apple 100 CT
. rdf 2 6 peach F1' lOOCT.rdf 3 6 straw New F1' lOOCT.rdf

EPA Crop Commodity Name Def Res Adj.Factors ROLComment Code Grp (ppm) Ill #2 Pntr



### -------- -- ------------------------------- 

## --·------- ----- -- 1100007000 11 Apple, fruit with peel 7.000000 0
. 790 1.000 1 1100008000 11 Apple, peeled fruit 7.000000 0
. 790 1.000 1 1100008001 11 Apple, peeled fruit

- baby food 7.000000 0.790 1.000 1 1100009000 11 Apple, dr ied 3 .72 0000 2.400 1
. 000 1100009001 11 Apple, dried

- babyfood 3.720000 2.400 1.000 1100010000 11 Apple, juice 7.000000 0.120 1
. 000 1 110001000 1 11 Apple
. juice-babyfood 7.000000 0
. 120 1.000 1 1100011000 11 Apple, sauce 7.000000 0.180 1.000 1 1100011001 11 Apple, sauce-babyfood 7.000000 0.180 1. 000 1 1202260000 12B Peach 6.420000 0.790 1.000 2 1202260001 12B Peach -babyfood 6.420000 0 .18 0 1.000 2 1202261000 128 Peach, dried 3.260000 2 .4 00 1.000 1202261001 128 Peach , dried -b abyfood 3
. 260000 2.400 1.000 1202262000 128 Peach, juic e 6.420000 0
. 120 1.000 2 1202262001 128 Peach, juice-babyfood 6.420000 0.120 1.000 2 1307359000 13G Strawberry ll. 400000 0.420 1.000 3 1307359001 13G Strawberry- baby food 11.400000 0.180 1.000 3 1307360000 13G Strawberry, juice 11.400000 0
. 120 1.000 3 1307360001 13G Strawberry, juice -babyfo od ll.400000 0.120 1. 000 3 8601000000 86A Water, direct, all sourc es 0
. 047800 1.000 1.000 8602000000 86B Water, indirect, a ll sources 0.047800 1.000 1. 000 9500020000 0 Avocado 0.050000 1. 000 1 .000 Pulp R Full comment: Pulp Residues 9500023000 0 Banana 0.276000 1.000 1.000 Pulp R Full comment: Pulp Residues 9500023001 0 Banana

- babyfood 0.276000 1.000 1.000 Pulp R Full comment: Pulp Residues 9500024000 0 Banana, dried 0 .119000 2.400 1.000 Pulp R Full comment: Pulp Residues 9500024001 0 Banan a, dried-babyfood 0 .119000 2.400 1.000 Pulp R Full comment: Pulp Residues 9500283000 0 Plantain 0.276000 1.000 1 .000 950028 4000 0 Pla ntain, dried 0
. 27600 0 2.400 1. 000

Page 10of1 5Thi ram Dietary Expos ure and Ri s k Assessment 

### Residue Distribution File s (rdfs)

RDF #1 'Apples '100\- Ct TOTALZ=O TOTALNZ :20 0.95 2.09 0.91 1. 41 4.22 0.86 8.65 5.18 6.75 4.56 2.93 3.98 4.24 4.69 5.60 5.97 6.53 1.62 1. 72 1.72 RDF #2 'Peaches '100\- CT TOTALZ=O TOTALNZ=21 3.29 6 .4 2 3.04 3. 4 7 4. 54 5.93 2.19 2.61 2.98 1.47 1.90 3.17 2.49 1. 90 3
. 10 3.37 5.38 3.95 2.24 1.73 1.91 RDF # 3 'Stra wberries '100\- CT TOTALZ=O TOTALNZ=lO 3.45 3.15 4.30 0.05 4 11.4 5.40 5.3 4.2 7.65
Page 11 of 15 DP # 427382Thi r am Di etary Exposure and Ri sk Asse ss m e nt OP# 4273 8 2 Attac hme nt 2 - Res ul ts of Ac ute Dietary A n a lys is fo r Thi ram
us EPA Ver. 3.18, 03-08-d DEEM

- FC I D ACUTE Analysis for THIRAM Nt!ANES 2003

- 2008 2-Day Residue file: 079801 Acute Food and Water.R OS Adjustment factor tt2 u sed. Analysi s Date: 05-20-2015/08:48:47 Residue file dated: 05-20-2015/08:29:07 Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports RAC / FF intake summed over 24 hours MC iterations = 1000; MC list in residue file; MC seed = 10821; RNG = MS VB Run Comment: "" 

### =

===== ========== = === ===== ======= ======= ============= ====== ========== ======= ==== Summary calculations--per capita : 95th Percentile 99th Percentile 99.9th Percentile Exposure \ a PAD Exposure \ aPAD Exposure \ aPAD



### --- ---- --- -------· ... 

## - ....... 

## -- ..... 

## - -------- ---------- 

## -------· Total us Population : 0
. 012002 l. 85 0.027 4 61 4
. 23 0
. 063009 9.70 All Infants: 0
. 027109 4. 1 7 0
. 049614 7.64 0.094657 14. 58 Children 1-2: 0.043503 6.70 0.076468 ll. 78 0.124955 19.24 Children 3-5 : 0.032302 4.97 0
. 0553 47 8.52 0 .095417 14. 69 Children 6-12: 0.018667 2
. 87 0.036479 5
. 62 0.065747 10.12 Youth 13-19: 0.009851 l. 5 2 0
. 018809 2.90 0
. 0302 9 5 4
. 67 A

d ults 20

- 49: 0.007907 l
. 22 0.015890 2. 45 0
. 029075 4.48 Adults 50-99: 0
. 008705 l. 34 0 .015894 2. 45 0.029378 4.52 Female 13-49: 0.008595 61. 39 0.016835 1 20.25 0
. 027699 197.85 

### FOOD O N LY
us EPA Ver. 3.18, 03-08-d DEEM-FCID ACurE Analysis for THIRAM Nt!ANES 2003-2008 2-0ay Residue file: 07 9801 Acute Food Only
. ROB Adjustment factor**~2** used. Analysis Date: 05-20-2015/09:04:07 Residue file d a ted: 05-20-2015/08 : 29:32 Acute Pop Adjusted Dose (aPAD) varies with population; see individual reports RAC / FF intake summed over 24 hou r s M

C iterations = 1000 ; M C list in r e s i d ue file ; M C s eed = 10821; RNG = MS VB Run Comment : " "**== ====** **======= ==========** **===~••== ==** **=== ====** **~aa a=** **==== ===** **===== =:=====** **=== ==** **==== =~** **•••** Summary calculations--per capita : 9Sth Percentile 99th Percentile 99.9th Percentile Exposure \ a PAD Exposure \ aPAD Exposure \ aPAD



### -- --- ----- ........... ........... ........................... 

### -------- .................. 

## -- ... 

## -------- Total us Population : 0
. 010689 l
. 65 0.025967 4. 00 0
. 06 1 0 1 8 9. 40 All Infants: 0.024158 3
. 72 0.046598 7.18 0.092802 14 .29 Children l-2 : 0
. 0 418 12 6
. 44 0
. 07 4672 ll.50 0 .122934 18 .93 Children 3-5: 0.030800 4. 7 4 0.053764 8.28 0.092509 14.25 Children 6-12 : 0
. 017630 2
. 71 0.034989 5. 39 0.06345 4 9.77 Youth 13 -1 9: 0
. 008878 l. 37 0.017645 2
. 72 0.0293 8 5 4.52 A

dults 20-49: 0.006629 l.02 0.0 14500 2.23 0.027338 4.2 1 Adults 50-99: 0
. 007582 l.17 0
. 0 145 08 2.23 0.027807 4.28 Female 13- 4 9: 0
. 007290 52
. 07 0
. 015458 11 0
. 42 0
. 026198 187.13
Pag e 12of 15Thi ram Dietary Exposure and Ri s k Assessme nt DP # 427382



### Attac hme nt 3- Residue Input s for Chronic Di e tary Assess m e nt ofThiram
Filename : C : \Users\tmorton\Documents\My Files\DEEM Files\079801 Thiram\Banana and Avocado Rerun\079801 Chronic Food And W ater.ROS Chemical: Thiram RfD(Chronicl: .015 mg/kg bw/day NOEL(Chronic): O mg/kg bw/day RfD(Acute): O mg/kg bw/day NOEL(Acute): O mg/kg bw/day Date created/last modified: 12-16-201 4 / 11:12:06 Program ver. 3.16, 03-08-d Crop EPA Code Grp Commodity Name 1100007000 11 1100008000 11 1100008001 11 1100009000 11 1100009001 11 1100010000 11 11000 10001 11 1100011000 11 1100011001 11 1202260000 12B 1202260001 12B 1202261000 12B 1202261001 12B 1202262000 12B 1202262001 12B 1307359000 13G 1307359001 13G 1307360000 13G 1307360001 13G 8601000000 86A 8602000000 86B 9500020000 0 Apple, fruit with peel Apple, peeled fruit Apple, peeled fruit-babyfood Apple, dried Apple, dried-babyfood Apple, juice Apple, juice-babyfood Apple, sauce Apple, sauce-babyfood Peach Peach-babyfood Peach, dried Peach, dried-babyfood Peach, juice Peach, juice-babyfood Strawberry Strawberry

- babyfood Strawberry, juice Strawberry, juice-babyfood Water, direct, all sources Water, indirect, all sources Avocado Full comment: Pulp Residues 9500023000 0 Banana Full comment: Pulp Residues 9500023001 O Banana-babyfood Full comment: Pulp Residues 9500024000 O Banana, dried Ful l comment: Pulp Residues 9500024001 O Banana, dried-baby food Full comment: Pulp Residues 9500283000 0 Pla n tain 9500284000 0 Plantain, dried Def Res (ppm) Adj.Factors #1 112 Comment
3
. 720000 0
. 790 1.000 3.720000 0
. 790 1.000 3
. 720000 0
. 790 1.000 3
. 720000 2.40 0 1
. 000 3
. 720000 2.400 l.000 3
. 720000 0.120 1.000 3.720000 0
. 120 1.000 3.720000 0 .1 80 1.000 3.720000 0
. 180 1.000 3.260000 0 .79 0 1.000 3.260000 0.180 1.000 3.260000 2.400 1.000 3.260000 2.4 00 1.000 3.260000 0
. 120 1.000 3.260000 0 .12 0 1.000 4.900000 0 .42 0 1.000 4.900000 0.180 1
. 000 4.900000 0 .1 20 1
. 000 4.900000 0.120 1
. 000 0
. 002500 l
. 000 1.000 0.002500 1.000 1.000 0.050000 l
. 000 1.000 Pulp R 0.119000 1
. 000 1.000 Pulp R 0.119000 1
. 000 1.000 Pulp R 0.119000 2
. 400 l.000 Pulp R 0.119000 2
. 400 1.000 Pulp R 0
. 121000 1. 000 1.000 0.121000 2
. 400 1.000

Page 13of 1 5Thi ram Dietary Exposure and Ri sk Asse ss m en t DP# 427382



### A tt ac hment 4 - Re s ults of P artially Refined Chronic Dietary Analysis for Thiram
us EPA Ver. 3
. 16 , 03-08-d DEEM-FCI D Chronic analysis for T H I RAM NHANES 2003-2008 2-day Residue file name: C:\Users\tmorton \ D ocuments\My Files \DEEM F iles\079801 Thiram \Bana na and Avocado Rerun \079801 Chronic Food And Water.ROS Adjustment factor #2 used. Analysis Date 05-20-2015/08:32:48 Residue file dated: 05

- 20-2015/08 : 30 : 29 Reference dose (RfD, Chronic) 

### = .015 mg /kg bw / day 

### =================== ====== ====================================================== Total exposure b y population subgroup

Population

Subgroup Total US Population Hispanic Non-Hisp-White Non-Hisp -B lack Non-Hisp -O ther Nursing I nfant s Non

- Nursing Infants Female 13+ PREG Children 1-6 Children 7-12 Male 13-19 Female 13

- 19/NP Male 20+ Female 20+/NP Seniors 55+ All Infants Female 13-50 Children 1-2 Children 3-5 Children 6-12 Youth 13-19 Adults 20

- 49 Adults 50-99 Female 13

- 49 Total Exposure mg/kg body wt /day 0.001999 0.002621 0
. 001912 0.001667 0
. 002337 0.003534 0
. 006214 0
. 001699 0.007919 0.003014 0. 001317 0.00 1 510 0. 001119 0.00 12 99 0
. 001459 0
. 005387 0.001193 0.010557 0
. 006870 0 .003 359 0.001413 0 .001077 0.001421 0
. 001186

Page 14of1 5 Percent of Rfd 13
. 3\ 17.5\ 12.7\ 11.1\ 15 .6 \ 23 .6\ 4 1.4\ 11.3\ 52.8\ 20
. 1\

8.8\ 10 .1\

7 .5 \ 8. 7\ 9.7\ 35.9\

8.0\ 70
. 4\ 45
. 8\ 22 .4\

9 .4\ 7.2\ 9.5\ 7 .9\T hira m Di e tary E xposure and Ri s k Assess me nt DP# 4 273 8 2



### FOOD ONLY

us EPA Ver. 3.16, 03-08-d DEEM-FCID Chronic analysis for THIRAM NHANES 2003 -2008 2-day Residue file name: C:\Users\tmorton\Documents\My Files\DEEM Files \079801 Thiram\Banana a nd Avocado Rerun \07 9801 Chronic Food Only.ROS Adjustment factor #2 used. Analysis Date 05-20-2015/08:33:07 Residue file dated: 05-20-2015/08:31:23 Reference dose (RfD , Chronic) = .015 mg/kg bw /day
==== ==================•a=n •ac ====== == == = ====== ================================= Total exposure by population subgroup

Pop ulation

Subgroup Total us Population Hispanic Non-Hisp

- White Non-Hisp-Black Non -His p-Other Nursing Infants Non-Nursing Infants Female 13+ PREG Children 1

- 6 Children 7

- 12 Male 13-19 Female 13-19/NP Male 20+ Female 20+/NP Seniors 55+ All Infants Female 13-50 Children 1-2 Children 3-5 Children 6

- 12 Youth 13-19 Adults 20- 4 9 Adults 50-99 Female 13-49 Total Exposure mg/kg body wt /day 0.001947 0.002571 0
. 001858 0.001624 0.002276 0.003487 0.006040 0.001649 0.007852 0.002970 0
. 001281 0.001470 0.001070 0.0012 44 0.001408 0
. 005252 0.001141 0.010482 0.006807 0.003313 0.001375 0
. 001025 0.001369 0. 001134

Page 1 5o f15 Percent of Rfd 13.0t 17. lt 12 .4\' 10. et 15.2\' 23.2\' 40.3\' 11. Ot 52

. 3\ 19.8\'

8.5\' 9.8\' 7. lt 8.3\' 9. 4\' 35.0t

7.6\' 69.9\' 45.4\' 22. lt

9.2\' 6.8\' 9.1\' 7.6\