Flonicamid Dietary Exposure Assessment DP Barcode: 04 13405 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

MEMORANDUM 

DATE: 08/14/2013 

OFFICE OF CHEMICAL SAFETY 

AND POLLUTION PREVENTION 

SUBJECT: Flonicamid Chronic Aggregate Dietary (Food and Drinking Water) Exposure and 

Risk Assessments for the Section 3 Registration Actions on Tree Nuts, Alfalfa, 

Clover, Spearmint, Peppermint, and Cucurbit Group 9, and Crop Group 

Conversions for Fruiting Vegetable Group 8-10, Po me Fruit Group 11 -10, and 

Stone Fruit Group 12-12. 

PC Code: 1280 16 

Decision No.: 473586 

Petition Nos.: 2F8088, 2£8137 

Assessment Type: Single ChemicaVAggregate 

TXR No.: NA 

MRID No.: NA 

DP Barcode: 04 13405 

Registration Nos.: 7 1512-9,715 12-10 

Regulatory Action: Section 3 Registration 

Case No.: NA 

CAS No.: 158062-67-0 

40 CFR: § 180.613 

REVIEWER: Nancy Dodd, Chemist ~ £7~ Risk Assessment Branch III ?7 

Health Effects Division (7509P) 

THROUGH: Sheila Piper, Senior Chemist Jrlu.J .. o~ (}2,~' ~ Mohsen Sahafeyan, Chemist :;J/~ ~~~~~- Dietary Exposure Science Advisory Council (D 

Health Effects Division (7509P) 

Chr

Risk 

istine 

Assessment 

Olinger, 

Branch 

Branch 

III 

Chief~ Health Effects Division (7509P). 

TO: Barry O'Keefe, Risk Assessor 

Risk Assessment Branch III 

Health Effects Division (7509P) 

and 

Richard Gebken/Carmen Rodia, RM# 1 0 

Registration Division (7505P) 

and 

Barbara Madden/Andrew Ertman, RM#5 

Registration Division (7505P) 

Page 1 of 13 
Flonicamid Dietary Exposure Assessment DP Barcode: 0413405 

Executive Summary 

Chronic aggregate dietary (food and drinking water) exposure and risk assessments were 

conducted using the Dietary Exposure Evaluation Model software with the Food Commodity 

Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 food consumption 

data from the U.S. Department of Agriculture's (USDA's) National Health and Nutrition 

Examination Survey, What We Eat in America (NHANES/WWEIA). The analysis was 

conducted in support of a human-health risk assessment for the proposed Section 3 uses of 

flonicamid on tree nuts, alfalfa, clover, spearmint, peppermint, and cucurbit group 9, and for crop 

group conversions for fruiting vegetable group 8-10, pome fruit group 11-1 0, and stone fruit 

group 12-12. This memorandum was reviewed by two peer reviewers of the DESAC, per 

DESAC SOP 2012.1. 

Chronic Dietary Exposure Results and Characterization 

Tolerance-level residues combined with 100% crop treated were used to determine the chronic 

dietary exposure and risk estimates. Drinking water was incorporated directly into the dietary 

assessment. The chronic dietary exposure estimates for food and drinking water are below 

HED's level of concern for the general U.S. population [12% of the chronic population adjusted 

dose ( cP AD)] and the most highly exposed population subgroup, children 1 - 2 years old (30% of 

the cPAD). 

Acute Dietary Exposure Results and Characterization 

An acute dietary risk assessment was not performed as flonicamid has no acute toxicological 

endpoint. 

Cancer Dietary Exposure Results and Characterization 

A cancer dietary assessment was not conducted as flonicamid has been determined to be 

"Suggestive Evidence of Carcinogenicity, but Not Sufficient to Assess Human Carcinogenic 

Potential". 

I. Introduction 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to point 

of departure (POD) (e.g., NOAEL, LOAEL) divided by the required uncertainty or safety 

factors. 

For non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% 

of the PAD. References that discuss the acute and chronic risk assessments in more detail are 

available on the EPA/pesticides web site: "Available Information on Assessing Exposure from 

Page 2 of 13 
Flonicamid Dietary Exposure Assessment DP Barcode: 0 4 13405 

Pesticides, A User's Guide," 21-JUN-2000, web linlc http://www.epa.gov/fedrgstr!EPAPEST/2000/July/Day- 12/6061.pdf; or see SOP 99.6 (20-AUG-1999). 

The most recent dietary risk assessment for flonicamid was conducted by Cassi L. Walls, Ph.D. 

(27-SEP-2012, DP Number D397279). 

II. Residue Information 

Flonicamid Use 

Flonicamid is a Group 9C insecticide (selective feeding blocker) registered for the control of a 

variety of aphid pests and the suppression of a variety of non-aphid pests. Tolerances for 

registered commodities can be found in 40 CFR§ 180.613. The tolerances that are currently 

being recommended are listed in Table 1, below. The residues of concern inion plants are the 

parent flonicamid and its major metabolites, TFNA-AM, TFNA, and TFNG; and inion ruminants 

are the parent and its metabolites TFNA-AM and TFNA. 

Residue Data used for Chronic Assessments 

The residue levels used in the chronic assessment were the tolerance levels for plant 

commodities established under 40 CFR § 180.613 and the HED recommended tolerance levels 

based on the crop field trials for the proposed crops. The livestock commodity tolerances are 

changed from the previous assessment. Tables 1 a and I b present summaries of the tolerance 

residue levels used in the chronic assessment for plants and livestock commodities, respectively. 

Estimated concentrations of flonicamid in drinking water from the proposed uses were provided 

by EFED and incorporated directly into the chronic assessment. 

Table 1 a. Plant Tolerance Summar y for Proposed Uses of Flonicamid 

Commodity Proposed Tolerance HED Recommended 

(ppm) Tolerance 

{0_>_m) 

Alfa lfa, forage 7.0 10.0 

Alfa lfa, hay 0.20 1.0 

Alfalfa, seed 1.5 1.5 

Almond, hulls 10.0 9.0 

Clover, forage 7.0 none 

Clover, hay 4.0 none 

Fruit, pome, group Il-l 0 0.20 0.20 

Fruit, stone, group 12-12 0.60 0.60 

Nut, tree, group 14-12 0.09 0.15 

Peppermint, tops 7.0 7.0 

Spearmint, tops 7.0 7.0 

Vegetable, cucurbit, group 9 1.5 1.5 

Vegetable, fruiting, group 8- 10 0.40 0.40 

Page 3 of 13 
Flonicamid Dietary Exposure Assessment DP Barcode: 0413405 

Table 1 b. Livestock Tolerance Summary for Proposed Uses of Flonicamid 

Commodity Established Tolerance HEO Recommended 

(ppm) Tolerance 

JI>Q_m_l 

Cattle, fat 0.03 0.03 

Cattle, meat 0.08 0.08 

Cattle, meat byproducts 0.08 0.08 

Egg 0.04 0.04 

Goat, fat 0.03 0.03 

Goat, meat 0.08 0.08 

Goat, meat byproducts 0.08 0.08 

Hog, fat none 0.03 

Hog, meat none 0.03 

Hog, meat byproducts none 0.03 

Horse, fat 0.03 0.03 

Horse, meat 0.08 0.08 

Horse, meat byproducts 0.08 0.08 

Milk 0.03 0.05 

Poultry, fat 0.03 0.03 

Poultry, meat 0.03 0.03 

Poultry, meat byproducts 0.03 0.03 

Sheep, fat 0.03 0.03 

Sheep, meat 0.08 0.08 

Sheep, meat byproducts 0.08 0.08 

Processing Factors 

Separate tolerances were established for dried potatoes, tomato paste, and tomato puree based on 

processing studies. The processing factor was set to 1.0 for these commodities. DEEM default 

processing factors were used for the other processed commodities for which default processing 

factors are available. 

Fish, Catfish 

The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 2009, 

and 2010. In general, pesticide residues would not be expected to be found in fish unless the 

pesticide bioaccurnulates or has an aquatic use. To determine whether or not residues are present 

in fish, HED now routinely checks PDP monitoring data regardless of the pesticide's uses and 

physicochemical properties. However, PDP did not analyze catfish samples for flonicamid. As 

a result, residues in fish were not included in the assessment." 

III. Percent Crop Treated 

The assessment used 100% crop treated for all agricultural commodities. 

Page 4 of 13 
Flonicamid Dietary Exposure Assessment DP Barcode: 0413405 

IV. Drinking Water 

The drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED) in the following memorandum: "Drinking 

Water Assessment to Assess Flonicamid Use on Alfalfa and Clover Grown for Seed, Fruiting 

Vegetables, Mint, Tree Nuts, and the Expansion to the Full Crop Group for Pome Fruit and 

Stone Fruit" (J. Hetrick, Ph.D., D408552, 6/24/13) and incorporated directly into this 

assessment. Water residues were incorporated in the DEEM-FCID into the food categories 

"water, direct, all sources" and "water, indirect, all sources." 

No monitoring data of flonicamid were available to EFED. The estimated drinking water 

concentrations (EDWCs) used in this assessment are from the Pesticide Root Zone ModelGround Water (PRZM-GW). The concentration of total toxic residues of flonicamid (i.e., 

flonicarnid and its major metabolites, TFNG, TFNA, TFNA-OH, TFNA-AM, and TFNG-AM) in 

ground water is predicted to not exceed 15.9 ug/L for the daily peak (acute) and 9.92 ug/L for the 

30 year annual average, which was used in this chronic assessment. These concentrations are 

associated with the proposed increased application rate of 0.133 lb ai/ A/application with two 

applications on fruiting vegetables in WI. The model and its description are available at the EPA 

internet site: http://www.epa.gov/oppefedl /models/water/. Flonicamid may be applied by aerial, 

ground, or chemigation as per the labels for this product. 

V. DEEM-FCIDTM Program and Consumption Information 

The flonicamid chronic dietary exposure assessment was conducted using the DEEM-FCID, 

Version 3.16, which incorporates 2003-2008 consumption data from USDA's 

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods "as consumed" (e.g., apple pie) are 

linked to EPA-defined food commodities (e.g., apples, peeled fruit- cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups. However, for acute 

exposure assessment, consumption data are retained as individual consumption events. Based on 

analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns 

and survey respondents, HED concluded that it is most appropriate to report risk for the 

following population subgroups: the general U.S. population, all infants (<1 year old), children 

1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 

years old. 

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup. 

Page 5 of 13 
Flonicamid Dietary Exposure Assessment DP Barcode: D413405 

VI. Toxicological Information 

The toxicity database for flonicamid was evaluated by HED's Toxicology Team on 9/30/2004. 

The team selected endpoints and evaluated for FQPA concerns based on the potential hazard and 

exposure data for flonicamid and determined that there was no need for an additional safety 

factor for the protection of infants and children. Flonicamid is classified to be category 

"Suggestive Evidence of Carcinogenicity, but Not Sufficient to Assess Human Carcinogenic 

Potential," according to the EPA Draft Guidelines for Carcinogen Risk Assessment dated July, 

1999; therefore, a cancer assessment is not necessary. HED's current toxicology team has 

reevaluated the endpoints and determined they are acceptable and applicable for risk assessment 

purposes. 

Table 2. Toxicological Doses and Endpoints for Flonicamid for Use in Dietary Health Risk 

Assessments. 

Exposure/ Point of Uncertainty/ RID, PAD, Level 

Scenario Departure FQPA Safety of Concern for Study and Toxicological Effects 

Factors Risk Assessment 

Acute Dietary No appropriate endpoint attributable to a single dose (exposure) was identified in oral toxicity 

(General studies. Therefore, an acute RID was not established. 

population) 

Chronic Dietary NOAEL= 4.0 UFA = 10 Chronic RID = 2-Gen reproduction study in the rat. 

(All Populations) mglkg/day UFH = 10 0.04 mg/kg/day Parental LOAEL = 22 rng/kg/day based 

FQPA SF= l x on increased kidney weights, kidney 

cPAD = 0.04 hyaline deposition, increased blood 

rng/kg!dav serum LH (F I females). 

Cancer (oral, Classification: Classified as "Suggestive Evidence of Carcinogenicity, but Not Sufficient to 

dermal, Assess Human Carcinogenic Potential" 

inhalation) 

Pomt of Departure (POD) = A data pomt or an estimated pomt that IS denved from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA = extrapolation from animal to human (interspecies). UFH =potential variation in 

sensitivity among members of the human population (intraspecies). FQPA SF= FQPA Safety Factor. PAD= 

population adjusted dose (a= acute, c = chronic). RID = reference dose. 

VII. Results/Discussion 

As stated above, for chronic assessments, HED is concerned when dietary risk exceeds 100% of 

the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the U.S. population and 

various population subgroups. The results reported in Table 3 below are for the general U.S. 

population, all infants ( < 1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, 

females 13-49, adults 20-49, and adults 50-99 years old. 

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis 

The results of the chronic dietary (food and drinking water) exposure analysis are reported in 

Table 3 below. 

Page 6 of 13 
Flonicamid Dietary Exposure Assessment DP Barcode: 0413405 

The chronic dietary (food and drinking water) exposure to flonicarnid is below HED's level of 

concern for the general U.S. population and all population subgroups. The chronic dietary 

exposure estimates are 12% cPAD for the general U.S. population and 30% cPAD for children 1 w 

2 years old, the most highly exposed population subgroup. 

Table3. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Flonicamid1 

cPAD Exposure (mg/kg/day) %cPAD 

Population Subgroup (mg/kg/day) DEEM-FClD DEEM-FCID 

General U.S. Population 0.004720 12 

All Infants(< I year old) 0.006718 17 

Childr en 1-2 years old 0.011869 30 

Children 3-5 years old 0.008864 22 

Children 6-12 years old 0.04 0.005336 13 

Youth 13-19 years old 0.003402 8.5 

Adults 20-49 years old 0.004100 10 

Females 13-49 years old 0.004197 10 

Adults 50-99 years old 0.004501 II 0 0 I The populatiOn with the h1ghest exposure 1s m bold 

VIII. Characterization of Inputs/Outputs 

The chronic dietary exposure analysis is considered to be conservative since it uses tolerancelevel residues and 100% crop treated. As a result, HED is confident that exposure is not 

underestimated to the U.S. population or any population subgroup. Further refinements could be 

made~ however, they are not necessary at the present time. 

IX. Conclusions 

The chronic dietary exposure assessment was a conservative assessment, conducted using 

tolerance-level residues and 100% crop treated. Estimated concentrations of flonicarnid in 

drinking water from the proposed uses were provided by EFED and incorporated directly into the 

chronic assessments. 

The chronic dietary (food and drinking water) exposure to flonicamid is below HED's level of 

concern for the general U.S. population and all population subgroups. The chronic dietary 

exposure estimates are 12% cPAD for the general U.S. population and 30% cPAD for children 1-

2 years old, the most highly exposed population subgroup. 

X. List of Attachments 

Attachment 1: Chronic Residue Input File. 

Attachment 2: Chronic Results File. 

Page 7 of 13 
Flonicamid Dietary Exposure Assessment DP Barcode: 0413405 

Attachment 1: Chronic Residue Input File 

Filename: C:\Documents and Settings\NDODD\My Documents\DEEM Version 

3.16\Flonicamid\FLONICAMID081413.R08 

Chemical : FLONICAMID 

RfD(Chronic): .04 mg/kg bw/day NOEL(Chronic): 4 mg/kg bw/day 

RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day 

Date created/last modified: 08 - 14 -2013 /16:45:00 Program ver. 3.16, 03-08 - d 

Comment: CHRONIC ONLY 

EPA Crop 

Code Grp Commodity Name 

0101050000 lAB 

0101050001 lAB 

0101067000 lAB 

0101078000 l AB 

0101078001 l AB 

0101079000 lAB 

0101084000 lAB 

0101100000 l AB 

0101168000 l AB 

0101190000 lAB 

0101250000 lAB 

0101251000 lAB 

0101 251001 lAB 

0101314000 lAB 

0101316000 lAB 

0101327000 l AB 

0101331000 l AB 

0101388000 lAB 

0103015000 lCD 

010301 5001 l CD 

0103017000 lCD 

0103082000 lCD 

0103082001 lCD 

0103139000 lCD 

0103166000 1CD 

0103166001 1CD 

0103167000 lCD 

0103296000 1C 

0103297000 1C 

0103297001 1C 

0103298000 lC 

0103298001 l C 

0103299000 l C 

0103299001 l C 

0103300000 lC 

0103300001 l C 

0103366000 1CD 

0103366001 lCD 

0103371000 1CD 

0103387000 lCD 

0103406000 lCD 

0103407000 lCD 

0200315000 2 

0401005000 4A 

0401018000 4A 

040110400 0 4A 

0401133000 4A 

0401134000 4A 

0401138000 4A 

0401150000 4A 

0401204000 4A 

0401205000 4A 

0401248000 4A 

0401313000 4A 

Beet, garden, roots 

Beet, garden, roots- babyfood 

Burdock 

Carrot 

Carrot-babyfood 

Carrot, juice 

Celeriac 

Chicory, roots 

Ginseng, dried 

Horseradish 

Parsley, turnip rooted 

Parsnip 

Parsnip-baby food 

Radish, roots 

Radish, Oriental, roots 

Rutabaga 

Salsify, roots 

Turnip, roots 

Arrowroot, flour 

Arrowroot, flour- babyfood 

Artichoke, Jerusalem 

Cassava 

Cassava-babyfood 

Dasheen, corm 

Ginger 

Ginger-baby food 

Ginger, dried 

Potato, chips 

Potato, dry (granules/ flakes) 

Potato, dry (granules/ flakes) -b 

Potato, flour 

Potato, flour-babyfood 

Potato, tuber, w/peel 

Potato, tuber, w/peel- babyfood 

Potato, tuber, w/o peel 

Potato, tuber, w/o peel-babyfood 

Sweet potato 

Sweet potato-babyfood 

Tanier, corm 

TUrmeric 

Yam, true 

Yam bean 

Radish, tops 

Amaranth, leafy 

Arugula 

Chrysanthemum, garland 

Cress, garden 

Cress, upland 

Dandelion, leaves 

Endive 

Lettuce, head 

Lettuce, leaf 

Parsley, leaves 

Radicchio 

Def Res 

(ppm) 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.200000 

0 . 200000 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

0.400000 

0.400000 

0.400000 

0.400000 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

16.000000 

4.000000 

4.000000 

4.000000 

4.000000 

4.000000 

4.000000 

4.000000 

4 .000000 

4 .000000 

4.000000 

4.000000 

Page 8 of 13 

Adj.Factors 

#1 #2 

1 .000 

1 .000 

1 . 000 

1 . 000 

1.000 

1 .000 

1 . 000 

1.000 

1.000 

1 . 000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1. 000 

1.000 

1 .000 

1. 000 

1.000 

1.000 

1.000 

1 .000 

1.000 

1. 000 

1.000 

1.000 

1.000 

1 . 000 

1.000 

1.000 

1 .000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1 .000 

1 .000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1 . 000 

1. 000 

1. 000 

1.000 

1.000 

1.000 

1.000 

1 . 000 

1.000 

1.000 

1.000 

1 . 000 

1.000 

1.000 

1.000 

1. 000 

1 .000 

1.000 

1.000 

1. 000 

1.000 

1.000 

1.000 

1 .000 

1.000 

1.000 

1.000 

1.000 

1.000 

1. 000 

1.000 

1.000 

1.000 

1.000 

1 .000 

1.000 

1.000 

1.000 

1.000 

1. 000 

1.000 

1.000 

1. 000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

Comment 
Flonicamid Dietary Exposure Assessment DP Barcode: 0 413405 

04013SSOOO 4A Spinach 

04013SS001 4A Spinach-babyfood 

0402076000 4B Cardoon 

04020SSOOO 4B Celery 

04020SS001 4B Celery- babyfood 

04020S6000 4B Celery, juice 

04020S7000 4B Celcuce 

04021S2000 4B Fennel, Florence 

0402322000 4B Rhubarb 

0402367000 4B Swiss cha rd 

OS01061000 SA Broccoli 

OS01061001 SA Broccoli-babyf ood 

OS01062000 SA Broccoli , Chinese 

OS01064000 SA Brussels sproucs 

OS01069000 SA Cabbage 

OS01071000 SA Cabbage, Chinese, napa 

OS01072 000 SA Cabbage, Chinese , mustard 

OS010S3000 SA Cauliflower 

OS01196000 SA Kohlrabi 

OS02063000 SB Broccoli raab 

0502070000 5B Cabbage, Chinese, bok choy 

0502117000 5B Collar ds 

0502194000 5B Kale 

0502229000 5B Mustard greens 

OS0231SOOO 5B Rape greens 

OS023S9000 5B Turnip, greens 

OS0137 4000 SA Tomatillo 

OS01375000 SA Tomato 

OS0137S001 SA Toma to- babyfood 

OS01376000 SA 

OS01376001 SA 

Toma co, paste 

Tomato, paste-babyfood 

OS01377000 SA Toma to, puree 

OS01377001 SA Toma to, puree- babyfood 

OS0137SOOO SA Tomato, dried 

OS0137S001 SA Toma to, dried-babyf ood 

OS01379000 SA Toma to, juice 

OS013SOOOO SA Tomato, Tree 

OS0214SOOO SBC Eggplant 

OS02234000 SBC Okra 

OS02270000 SB Pepper, bell 

OS02270001 SB Pepper, bell- babyfood 

OS02271000 SB Pepper, bell, dried 

OS02271001 SB Pepper, b e ll, dried- babyfood 

OS02272000 SBC Pepper, nonbell 

OS0227200 1 SBC Pepper, nonbell-babyfood 

OS02273000 SBC Pepper, nonbell, dried 

09010 75000 9A Cant a loupe 

09011S7000 9A Honeydew me lon 

0901399000 9A Wa t ermelon 

0901400000 9A Watermel on, juice 

0902021000 9B Balsam pear 

0 9020SSOOO 9B Chayote, fruit 

0902102000 9B Ch i n ese waxgourd 

0902135000 9B Cuc umber 

090230SOOO 9B Pumpk in 

0902309000 9B Pumpkin, seed 

0902356000 9B Squash, summer 

09023S6001 9B Squash, summer- babyfood 

09023S7000 9B Squash, winter 

09023S7001 9B Squash, winter-babyfood 

1100007000 11 Apple, fruit with peel 

110000SOOO 11 Apple, peeled fruit 

110000S001 11 Apple, peeled fruit - babyfood 

1100009000 11 Apple, dried 

1100009001 11 Apple, dried- babyfood 

1100010000 11 Apple , JU~ce 

Full comment: 03293S1 

1100010001 11 Appl e , juice- babyfood 

1100011000 11 Apple, sauce 

9 . 000000 

9.000000 

4.000000 

4.000000 

4.000000 

4.000000 

4.000000 

4.000000 

4.000000 

4.000000 

1.500000 

1 .500000 

1.SOOOOO 

1.500000 

1. 500000 

1.500000 

1 . 500000 

1.500000 

1. 500000 

16. 000000 

16.000000 

16.000000 

16.000000 

16.000000 

16.000000 

16.000000 

0.400000 

0 .4 00000 

0. 400000 

1.000 1.000 

1. 000 1. 000 

1. 000 1. 000 

1.000 1. 000 

1.000 1. 000 

1.000 1. 000 

1.000 1. 000 

1.000 1. 000 

1.000 1. 000 

1. 000 1. 000 

l. 000 1. 000 

l. 000 1. 000 

1. 000 1. 000 

1 .000 1.000 

1.000 1 .000 

l. 000 1. 000 

1.000 1.000 

1.000 1.000 

1. 00 0 1. 000 

1 .000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1.000 1.000 

l. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

l. 000 1 . 000 

1. 000 l. 000 

2.000000 1.000 1.000 

2.000000 1.000 1.000 

0.500000 1.000 1.000 

0.500000 1.000 1.000 

0.400000 14.300 1.000 

0. 400000 14.300 1.000 

0.400000 1.500 1.000 

0.400000 1.000 1.000 

0.400000 1.000 1.000 

0 .400000 1.000 1.000 

0 .400000 1.000 1. 000 

0 .40000 0 1 . 000 1.000 

0. 400000 1.000 1.000 

0.400000 1.000 1 .000 

0. 400000 1 .000 1 .000 

0.40000 0 1 .000 1.000 

0. 400000 1 . 000 1 .000 

1 .SOOOOO 1.000 1 .000 

1.500000 1.000 1. 000 

1 . 500000 1.000 1. 000 

1 .SOOOOO 1.000 1 .000 

1 .500000 1.000 1 .000 

1 . SOOOOO 1 .000 1.000 

1.500000 1.000 1. 000 

1 .SOOOOO 1.000 1.000 

1 .SOOOOO 1.000 1 .000 

1.500000 1.000 1.000 

1.500000 1.000 1.000 

1 .500000 1 . 000 1.000 

1 . 500000 1.000 1.000 

1.SOOOOO 1.000 1.000 

0 . 200000 1.000 1 .000 

0.200000 1.000 1.000 

0.200000 1 . 000 1.000 

0.200000 s.ooo 1.000 

0.200000 s.ooo 1.000 

0 . 200000 1.000 1 .000 03293S 

0 . 200000 1.000 1. 000 

0 . 200000 1 . 00 0 1 .000 

Page 9 of 13 
Flonicamid Dietary Exposure Assessment 

1100011001 11 

1100129000 11 

1100173500 11 

1100210000 11 

1100266000 11 

1100266001 11 

1100267000 11 

1100268000 11 

1100268001 11 

1100310000 11 

1201090000 12A 

1201090001 12A 

1201091000 12A 

1201091001 12A 

1202012000 128 

1202012001 128 

1202013000 1 28 

1202014 000 128 

1202014001 128 

1 202230000 12B 

1202260000 128 

Apple, sauce-babyfood 

Crabapple 

Goji berry 

Loquat 

Pear 

Pear- babyfood 

Pear, dried 

Pear, juice 

Pear, juice- babyfood 

Quince 

Cherry 

Cherry-baby food 

Cherry, JUl.ce 

Cherry, juice-babyfood 

Apricot 

Apricot-babyfood 

Apricot, dried 

Apricot, juice 

Apricot, juice-babyfood 

Nectarine 

Peach 

1202260001 12B Peach- babyfood 

1202261000 12B Peach, dried 

1202261001 12B Peach, dried-babyfood 

1202262000 12B Peach, juice 

1202262001 12B Peach, juice-babyfood 

1203285000 12C Plum 

1203285001 12C Plum-babyfood 

1203286000 12C Plum, prune, fresh 

1203286001 12C Plum, prune, fresh-babyfood 

1203287000 12C Plum, prune, dried 

Full comment: 0290386 

1203287001 12C Plum, prune, dri ed-babyfood 

1203288000 12C Plum, prune, jui ce 

1203288001 12C Plum, prune, juice-babyfood 

1307130000 13G Cranberry 

1307130001 13G Cranberry- babyfood 

1307131000 13G Cranberry, dried 

1307132000 13G Cranberry, juice 

1307132001 13G Cranberry, juice- babyfood 

1307359000 13G Strawberry 

1307359001 13G Strawberry-babyfood 

1307360000 13G Strawberry, JUl.ce 

1307360001 13G Strawberry, juice- babyfood 

1400003000 14 Almond 

1400003001 14 Almond-babyfood 

1400004000 14 Almond, oil 

1400004001 14 Almond, oil-babyfood 

1400059000 14 Brazil nut 

1400068000 14 Butternut 

1400081000 14 

1400092000 14 

1400155000 14 

1400156000 14 

1400185000 14 

1400213000 14 

1400269000 14 

1400278000 14 

1400282000 14 

1400391000 14 

18 00002000 18 

2001163000 20A 

2001319000 20A 

20013 1 9001 20A 

2001336000 20A 

2001336001 20A 

2001337000 20A 

2001337001 20A 

2003128000 20C 

Cashew 

Chestnut 

Hazelnut 

Hazelnut, oil 

Hickory nut 

Macadamia nut 

Pecan 

Pine nut 

Pistachio 

Walnut 

Alfalfa, seed 

Fl ax seed, oil 

Rapeseed, oil 

Rapeseed, oil- babyfood 

Sesame, seed 

Sesame, seed-babyfood 

Sesame, oil 

Sesame, oil-babyfood 

Cottonseed, oil 

0.200000 

0.200000 

0.400000 

0.200000 

0.200000 

0 . 200000 

0.200000 

0.200000 

0.200000 

0.200000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

0.600000 

1.500000 

1 .500000 

1.500000 

1.500000 

1.500000 

1.500000 

1.500000 

1.500000 

1.500000 

0.150000 

0.150000 

0.150000 

0 . 150000 

0.150000 

0.150000 

0.150000 

0.150000 

0.150000 

0.150000 

0.150000 

0.150000 

0.150000 

0.150000 

0.150000 

0.150000 

1 . 500000 

1.500000 

1.500000 

1.500000 

1.500000 

1.500000 

1 .500000 

1.500000 

0.500000 

Page 10 of 13 

1.000 

1.000 

1. 000 

1.000 

1.000 

1 .000 

6.250 

1.000 

1 .000 

1 .000 

1.000 

1. 000 

1.500 

1.500 

1.000 

1.000 

6.000 

1.000 

1.000 

1 .000 

1 .000 

DP Barcode: 0413405 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1. 000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1 .000 

1.000 

1.000 1.000 

7.000 1.000 

7 . 000 1. 000 

l. 000 1. 000 

1. 000 1. 000 

1.000 1. 000 

1.000 1. 000 

1.000 1. 000 

1. 000 1. 000 

1.000 1.000 029038 

1. 000 1. 000 

1. 400 1. 000 

1.400 1. 000 

l. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 100 1. 000 

1.100 1. 000 

1.000 l. 000 

1.000 1.000 

1. 000 1. 000 

1.000 1.000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1 .000 1.000 

1 . 000 1.000 

1. 000 1. 000 

1. 000 

1.000 

1.000 

1.000 

1.000 

1.000 

1. 000 

1 .000 

1.000 

1.000 

1.000 

1 .000 

1 . 000 

1.000 

1 . 000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1 . 000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 

1.000 
Flonicamid Dietary Exposure Assessment 

2003128001 20C Cottonseed, oil- babyfood 0.500000 

0.080000 

0.080000 

0.080000 

0.080000 

0.080000 

0.030000 

0.030000 

0.080000 

0.080000 

0.080000 

0 . 080000 

0.080000 

0.030000 

0.080000 

0.080000 

0 . 080000 

0 .030000 

0.030000 

0 .030000 

0.030000 

0 . 030000 

0 . 030000 

0.030000 

0.030000 

0.030000 

0.080000 

0 . 080000 

0.080000 

0.030000 

0.030000 

0.080000 

0.080000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.050000 

0.030000 

0.030000 

0 . 030000 

0 . 030000 

0 . 03000 0 

0.030000 

0 . 030000 

0 . 030000 

0.030000 

0.030000 

0.030000 

0.030000 

0.030000 

0.030000 

0.030000 

0.030000 

0.030000 

0.030000 

0.030000 

0.030000 

0.030000 

0.030000 

0.030000 

0.030000 

0.040000 

0.040000 

0.040000 

0 . 040000 

0.040000 

3100044000 31 

3100044001 31 

3100045000 31 

3100046000 31 

3100046001 31 

310004 7000 31 

3100047001 31 

3100048000 31 

3100049000 31 

310004 9001 31 

3200169000 32 

3200170000 32 

3200171000 32 

3200172000 32 

3200173000 32 

3300189000 33 

3400290000 34 

3400290001 34 

3400291000 34 

3400292000 34 

3400292001 34 

3400293000 3 4 

3400293001 3 4 

3400294000 34 

3400295000 34 

3500339000 35 

3500339001 35 

3500340000 35 

3500341000 35 

3500341001 35 

3500342000 35 

3500343000 35 

3600222000 36 

3600222001 36 

3600223000 36 

3600223001 36 

3600224000 36 

3600224001 36 

3600225001 36 

4000093000 40 

4000093001 40 

4000094000 40 

4000095000 40 

4000095001 40 

4000096000 40 

4000096001 40 

4000097000 40 

4000097001 40 

5000382000 50 

5000382001 50 

5000383000 50 

5000383001 50 

5000384000 50 

5000384001 50 

5000385000 50 

5000385001 50 

5000386000 50 

5000386001 50 

6000301000 60 

6000302000 60 

6000303000 60 

6000304000 60 

6000305000 60 

7000145000 70 

7000145001 70 

7000146000 70 

7000146001 70 

7000147000 70 

Beef, meat 

Beef, meat-babyfood 

Beef, meat, dried 

Beef, meat byproducts 

Beef, meat byproducts- babyfood 

Beef, fat 

Beef, fat-babyfood 

Beef, kidney 

Beef, liver 

Beef, liver -babyfood 

Goat, meat 

Goat, meat byproducts 

Goat, fat 

Goat, k idney 

Goat, liver 

Horse, meat 

Pork, meat 

Pork, meat-babyfood 

Pork, skin 

Pork, meat byproducts 

Pork, meat byproducts-babyfood 

Pork, fat 

Pork , f a t -babyfood 

Pork, k idney 

Pork , live r 

Sheep , meat 

Sheep, meat-babyfood 

Sheep, meat byproducts 

Sheep, fat 

Sheep, fat-babyfood 

Sheep, kidney 

Sheep, liver 

Milk, fat 

Milk, fat-baby food/infant formu 

Milk, nonfat solids 

Milk, nonfat solids-baby f ood/in 

Milk, water 

Milk, water-babyfood/infant form 

Milk, sugar (lactosel -baby food/ 

Chicken, mea t 

Chicken, meat-babyfood 

Chicken, liver 

Chicken, meat byproduct s 

Ch icken, meat bypr oducts- babyfoo 

Chicken, fat 

Chicken, fat-babyfood 

Chicken, skin 

Chicken, skin- babyfood 

Turkey, meat 

Turkey, meat-babyfood 

Turkey, liver 

Turkey, liver-babyfood 

Turkey, meat byproducts 

Turkey, meat byproducts-babyfood 

Turkey, fat 

Turkey, fat-babyfood 

Turkey, skin 

Turkey, skin-babyfood 

Poultry, other, meat 

Poultry, other, liver 

Poultry, other, meat byproducts 

Poultry, other , fat 

Poultry, o ther, skin 

Egg, whole 

Egg, whole- babyfood 

Egg, white 

Egg, white (solids)-babyfood 

Egg, yolk 

Page 11 of 13 

DP Barcode: 0413405 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 920 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1.000 1. 000 

1.000 1.000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1 . 000 1. 000 

1.000 1.000 

1.000 1.000 

1. 000 1. 000 

1 . 000 1. 000 

1.000 1. 000 

1.000 1. 000 

1.000 1. 000 

1. 000 1. 000 

1.000 1.000 

1.000 1.000 

1.000 1.000 

1.000 1.000 

1.000 1.000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1.000 1.000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1.000 1 .000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1. 000 1. 000 

1.000 1.000 

1.000 1.000 
Flonicamid Dietary Exposure Assessment DP Barcode: 0413405 

7000147001 70 Egg, yolk-babyfood 0.040000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.009920 1.000 1.000 

8602000000 86B water, indirec t, all sources 0.009920 1. 000 1. 000 

9500188000 0 Hop 7.000000 1.000 1.000 

9500275000 0 Peppermint 7.00000 0 1.000 1.000 

9500276000 0 Peppermint, oil 7.000000 1. 000 1.000 

9500352000 0 Spear mint 7 .000000 1. 0 0 0 1 . 000 

9500353000 0 Spearmint, oil 7 .000000 1. 000 1 .000 

Page l2of 13 
Flonicamid Dietarv Exposure Assessment DP Barcode: 04 13405 

Attachment 2: Chronic Results File 

U.S. EPA Ver. 3 .16, 03-08-d 

DEEM-FCI D Chroni c a nalysis for FLONICAMI D NHANES 2003 - 2009 2-day 

Residue f i l e name: C:\Documents a nd Se ttings\NDODD\My Documents\DEEM Version 

3.16\Flon i camid \ FLONICAMID0814 1 3 .R08 

Adj u stme nt f a ctor #2 used. 

Analysis Date 08 - 14- 2013/16:46:44 Resi due file dated : 08 - 14 -2 01 3/16:45:00 

Reference d ose (RfD, Chronic) = .04 mg/kg bw/day 

COMMENT 1 : CHRONIC ONLY 

Total exposure by population subgroup 

Total Exposure 

Population 

Subgroup 

Total US Popul a tion 

Hispanic 

Non-Hisp-White 

Non-His p-Bl a c k 

Non-His p-Othe r 

Nursing Infants 

Non- Nursing Infants 

Female 13+ PREG 

Children 1 - 6 

Children 7-12 

Male 13-1 9 

Female 1 3-1 9/NP 

Male 20+ 

Female 20+/NP 

Seniors 55 + 

All I n fant s 

Femal e 13 - 50 

Children 1 - 2 

Chil dren 3-5 

Children 6-12 

Youth 13 - 19 

Adults 20- 49 

Adults 50-99 

Female 1 3-4 9 

mg/kg 

b ody wt/day 

0 . 004720 

0 . 004361 

0 . 004699 

0.004800 

0.005763 

0.004491 

0.007712 

0.004405 

0.009643 

0.005018 

0.003354 

0.003453 

0.003925 

0.004575 

0.004497 

0.006718 

0.004185 

0. 011869 

0.008864 

0.005336 

0.003402 

0. 004100 

0.004501 

0.004197 

Page 13 of 13 

Pe rcent of 

Rfd 

11. 8% 

10.9% 

1 1.7% 

12.0% 

14.4% 

11.2% 

19.3% 

ll.Ot 

24 .lt 

12.5t 

8.4% 

8.6t 

9.8t 

11.4% 

11.2t 

16 . 8t 

10.5% 

29. 7t 

22.2t 

13.3% 

8.5t 

10.3t 

11.3% 

10.5t