### Flonicamid Dietary Exposure Assess ment DP Barcode: 04 13405



### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON

, 

### D.C

. 20460



### MEMORANDUM

DATE: 08/14/2013 OFFICE OF CHEMICAL SAFETY AND POLLUTION PR E VENTION



### SUBJECT: F lonicamid Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessments for the Section 3 Registration Actions on Tree Nuts, Alfalfa, Clover, Spearmint, Peppermint
, and Cucurbit Group 9, and Crop Group Conversions f or Frui ting Vegetable Group 8-10
, Po me Fruit Group 11

- 10
, and Stone Fruit Gro up 12-12.

PC Co d e: 1280 16 Dec is io n No.: 473586 Peti tion Nos.: 2F8088, 2£8137 Assessment T y p e: Single Chem icaVAggregate TXR No.: NA MRID No.: NA DP Ba r code: 04 13405 Registration Nos.: 7 1512-9,715 12

- 10 Re g ulatory Ac tion: Section 3 Registration Case No.: NA CAS No.: 158062-67-0 40 CFR: § 180.613



### REVIEWER : Nancy D odd, Chemist

## ~**£7~** Ri sk Assessment Branch I II ?7 

### Health Effects Di vision (7509 P)

THROUGH: Sheila Piper, Senior Chemist 

# Jrl u.J

..

# o~**(}2,~ '** **~** Mohsen Sahafeyan, Chemist

# :;J/~**~~ ~~~-**  Dietary Exposure Science Advisory Counci l (D Health Effects Division (7509 P)

Chr i stine Olinger
, Branch

# Chie**f~** Risk Assessment Branch III Health Effects Division (7509P).

TO: Barry O ' Keefe, Risk Assessor Risk Assessment Branch III Heal t h Effects Division (7509P) and Richard Gebken/Carmen Rodia, RM# 1 0 Registration Division (7505 P) and Barbara Madden/Andrew Ertman, RM#5 Registration Divisio n (7505 P)

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### Flonicamid Di etary Expo sure Assessment DP Barcode: 0413405



### Executive Summary

Chronic aggregate dietary (food and drinking water) exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID) Version 3.16. Thi s software uses 2003-2008 food consumption data from the U

. S

. Department of Agriculture's (USDA's) National Health and Nutriti on Examination Survey, What We Eat in America (NHANES / WWEIA)

. The analysis was conducted in support of a human-health risk assessment for the proposed Sectio n 3 uses of flonicamid on tree nuts, alfalfa, clover, spearmint
, peppermint, and cucurbit gro up 9
, and for crop group conversions for fruiting vegetab le group 8-10, pome fru it group 1 1-1 0, and stone fruit group 12-12. This memorandum was reviewed by two peer reviewers of the DESAC, per DESAC SOP 2012.1.

Chronic Dietary Exposure Results and Characteriza tion

Tolerance

- level residues combined with 1 00% crop treated were used to determine the chronic dietary exposure and risk estimates. Drinking water was incorporated directly into the dietary
assessment. The chronic dietary exposure estima tes fo r food and drinking water are below HED's level of concern for the general U.S. population [ 12% of the chronic population adjusted dose (cPAD)] and the most highly exposed population subgroup, children 1

- 2 year s old (30% of the cPAD).

Acute Dietary Exposure Results and Characteriza tion

An acute dietary risk assessment was not performed as flonicamid has no acute toxicological endpoint.

Cancer Dietary Exposure Results and Characterization

A canc er dietary assessment was not conducted as flonicamid has been determined to be "Suggestive Evidence of Carcinogenicity, but Not Sufficient to Assess Human Carcinogenic Potential".

I. 

### Introduction

Dietary risk assessment incorporates both exposure and tox icity of a given pes ticide. For acute and chronic assessments, the risk i s expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population adjusted dose (PAD)

. The PAD is equivalent to point of departure (POD) (e.g., NOAEL
, LOAEL) divided by the required uncertainty or safety factors.

For non-cancer chronic exposures , HED is concerned when estimated dietary risk exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: "Available Information on Assessing Exposure from

Page 2 of 13Flonicamid D ietary Exposure Assessment DP Barcode: 0 4 13 4 0 5



### Pesticides
, A User's Guide," 21-JUN-2000, web linlc http: //www.epa.gov/fedrgstr!EPAPEST /2000/July/Day- 12/ 6061.pdf; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for flonicamid was conducted by Cassi L. 

### Walls, Ph .D. (27-SEP-2012, D P Number D397279).

II. R e s idu e Info rm ation

Flonicamid Use

Flonicamid is a Group 9C insect icide (selective feeding b locker) reg i stered for the control of a
vari ety of aphid pests and the suppress ion of a variety of non-ap hid pests

. To lerances f or

regis t e r

ed commo dities ca n be fo und in 40 CFR § 180.613. The to lerances that are currently be ing recomme nde d are li ste d in T ab le 1, be low

. T he res idu es of concern inio n pl ants are the pa rent flonicamid and its major metab o lites, T FNA-AM, TFNA, and TFNG; a nd ini on ruminants

are the parent and its metabo lites TFNA

-AM and TFNA.

Residue Data used for Chronic Assessments

The residue levels used in the chronic assessment were the tolerance levels for p lant commod ities established under 40 CFR § 180.613 and the HED recommended tolerance level s based on the crop field trials for the proposed crops. The livestock commodity to lerances are changed from the prev ious assess ment. Tables 1 a and I b present summaries of the tolerance residue levels used in the chronic assessment fo r plants and livestock commod ities, respectively.

Estimated concentrations of flonicamid in drinking water from the proposed uses were provided by EFED and incorporated directly into the chronic assessment.

Table 1a. Plant Tolerance Summa r y for Proposed Uses of Flonicamid Commodity Proposed Tolerance HED Recommended (ppm) Tolerance {0_>_m)
A l fa l fa, forage 7.0 10.0 A lfa l fa, hay 0.20 1.0 Alfa l fa, seed 1.5 1. 5 Almond, hulls 10.0 9.0 Clover, forage 7.0 none Clover
, hay 4.0 none Fruit, pome, group Il-l 0 0

. 20 0.20 Fruit, stone , group 12-12 0.60 0

. 60 Nut
, tree , group 14-12 0

.09 0.15 Peppermint
, tops 7

. 0 7.0 Spearmint
, tops 7.0 7.0 Vegetable
, cucurbit
, group 9 1.5 1.5 Vegetable, fruiting, group 8

- 10 0.40 0.40



### Page 3 of 13

### Flonicamid Dietary Exposure Assessment DP Barcode: 0413405

Table 1b. Livestock Tolerance Summary for Proposed Uses of Flonicamid Commodity Established Tolerance HEO Recommended (ppm) Tolerance JI>Q_m_l Catt le, fat 0.03 0.03 Cattle, meat 0

. 08 0

.08 Cattle, meat b yproducts 0.08 0.08 Egg 0.04 0.04 Goat, fat 0.03 0

. 03 Goat, meat 0

. 08 0.08 Goat
, meat byproduct s 0.08 0.08 Hog, fat none 0.03 Hog, meat none 0.03 H og, meat byproducts none 0.03 H orse, fat 0.03 0.03 Horse
, meat 0.08 0

.08 Horse
, meat byproducts 0

. 08 0 .0 8 

### Milk 0.03 0.05 Po ultry
, fat 0.03 0.03 Poultry
, meat 0.03 0.03 Poultry, meat byproducts 0

. 03 0.03 Sheep, fa t 0.03 0 .0 3 Sheep, meat 0.08 0.08 Sheep, meat byproduc ts 0.08 0. 0 8


### Processing Factors

Separate to lerances were established for dried potatoes , tomato paste , and tomato puree based on processing studies. T he processing factor was set to 1.0 for these commoditie s

. DEEM default processing factors were used for the other processed commodities for which default process ing factors are availab le.

Fish
, Catfish

The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008
, 2009
, and 20 10. I n general
, p es ticide residues would not be expected to be found in fish unl e ss the p esticide bioaccurnulate s or has an aquatic u se. To determine whether or not residues are present in fish, HED now routinely checks PDP monitoring data regardless of the pesticide ' s uses and physicochemical properties

. However , PD P did not analyze catfish samples for flonicamid. As

a resu lt, res idues in fish were not included in the assessment."



## III. Percent Crop Treated

The assessment used 100% crop treated for all agricultural commod ities.

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### Flonicamid Dietary Exposure Assessment DP Barcode: 0413405



### IV. Drinking Water



### The drinking water residues used in the dietary risk assessment were provided by the Environmental Fate and Effects Division (EFED) in the following memorandum: "Drinking Water Assessment to Assess Flonicamid Use on Alfalfa and C lover Grown for Seed, Fruiting Vegetables, Mint, Tree Nuts, and the Expans ion to the Full Crop Group for Pome Fruit and Stone Fruit" (J. 

### Hetrick, Ph.D., D408552
, 6/24/13) and incorporated directly into this
assessment. Water res idues were incorporated in the DEEM-FCID into the food categories "water, direct, all sources" and "water, indirect, all sources."

No moni toring data of flonicamid were available to EFED. T he estimated drinking water concentrations (EDWCs) used in this assessment are from the Pesticide Root Zone ModelGround Water (PRZM-GW)

. The concentra tion ofto tal toxic residues of flonicamid (i.e.
, flonicarnid and its major metabolites, TFNG, TFNA, TFNA-OH, TFNA-AM, and TFNG-AM) in ground water is predicted to not exceed 15.9 ug/L for the daily peak (acute) and 9.92 ug/L for the 30 year annual average, which was used in this chronic assessment. These concentrations are associated with the proposed increased application rate of 0.133 lb ai/ A/application with two applications on fruiting vegetables in WI. The mode l and its description are available at the EPA internet site: http: //www

.epa

. gov/oppefedl /models/water /

. Flonicamid may be applied by aerial, ground, or chemigation as per the label s for this product.

V. DEEM-FCIDTM Program and Consumption Information



### The flonicamid chronic dietary exposure assessment was conducted using the DEEM-FCID, Version 3

. 16, which incorporates 2003-2008 consumption data from USDA's NHANES/WWEIA

. The data are based on the reported consumption of more than 20,000 individu al s over two non

-consecutive survey days. Foods "as consumed" (e.g., apple pie) are linked to EPA-defined food commodities (e.g
., app les, peeled fruit- cooked; fresh or N/S; baked;

or wheat flour

- cooked; fresh or N/S
, baked) using publicly availab le recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data

are averaged for the entire U.S. population and within populat ion subgroups

. However, for acute exposure assessment, consumption data are retained as individual consumption events. Based on

analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it i s most appropriate to report risk for the follow ing popula tion subgroups : the general U.S. population, all infants (<1 year old), chil dren 1-2, children 3 -5
, children 6-12, youth 13-19, adults 20 -49
, females 13 -4 9, and adults 50-99 years o ld.

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange o r orange juice) on the food commodity residue list is multiplied by the average dail y consumption estimate for that food/food form to produce a residue intake estimate

. The resulting residue intake estimate for each food/ food form is summed with the residue intake estimates for all other food/food forms on the commodity residue li st to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure i s performed for each population subgroup.

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### Flonicamid Dietary Exposure Assessment DP Barcode: D413405



## VI. Toxicological Information

The toxicity database for flonicamid was evaluated by HED's Toxicology Team on 9/30/2004. The team selected endpoints and evaluated for FQPA concerns based on the potential hazard and exposure data for flonicamid and determined that there was no need for an additional safety factor for the protection of infants and children. Flonicamid is classified to be category "Suggestive Evidence of Carcinogenicity, but Not Sufficient to Assess Human Carcinogenic Potential," according to the EPA Draft Guidelines for Carcinogen Risk Assessment dated July, 1999; therefore, a cancer assessment is not necessary. HED's current toxicology team has reevaluated the endpoints and determined they are acceptable and applicable for risk assessment purposes.

Table 2. Toxicological Doses and Endpoints for Flonicamid for U se in Dietary Health Risk Assessments.
Expo su re/ Po int of Uncertainty/ RID
, PAD, L evel

Scenario Departure FQPA Safety of Concern for Study and Toxicologica l Effects Factors R isk Assessment Acute Dietary No appropriate endpoint attributable to a single dose (exposure) was identified in oral toxicity (General s tudi es

. Therefore, an acute RID was not established

. population)
Chron ic Dietary NOA EL= 4.0 UFA = 10 Chronic RID = 2-Gen reproduction study in the rat. (All Populations) mglkg/ day UFH = 10 0.04 mg/kg/day Parental LOAEL = 22 rng/kg/day based FQPA SF= l x on increased kidney weight s, kidney cPAD = 0.04 hyaline deposition
, increased blood rng/kg!dav serum LH (F I females). Cancer (oral, Classification: Classified as "Suggesti ve E vidence of Carcinogenicity, but Not Sufficient to dermal, Assess Human Carcinogenic Potential" inhalation) Pomt of Departure (POD) = A data pomt or an estimated pomt that IS 

### denved from observed dose-response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor

. UFA = extrapola tion from animal to human (interspecies). UFH =potent ial variation in sensitivity among members of the human population (intraspecies). FQPA SF= FQPA Safety Factor. PAD= population adjuste d dose (a= acute, c = chronic). RID = reference dose.



## VII. Results/Discussion

As stated above, for chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM

-FC IDTM analyses estimate the dietary exposure of the U.S. population and various population subgroups. The re sults reported in Table 3 below are for the general U

. S

. population, all infants (< 

### 1 year old), chi ldren 1-2, children 3

- 5
, children 6-12, youth 13-19
, females 13

-49, adults 20- 49, and adults 50-99 years old.

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis

The results of the chronic dietary (food and drinking water) exposure analysis are reported in Table 3 below.

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### Flonicamid Dietary Exposure Assessment DP Barcode: 0413405



### The chronic dietary (food and drinking water) exposure to flonicarnid i s below HED's level of

concern for the general U.S. population and all population subgroups. The chronic dietary exposure estimates are 12% cPAD for the general U.S. population and 30% cPAD for children 1

w 

### 2 years old, the most hi ghly expos ed population subgroup.

Table3

. Summary of Dietary ( Food and Drinking Water) Exposure and Risk for Flonicamid 1



### cPAD Exposure (mg/kg/ day) %cPAD Pop ulation Subgr o up (mg/ kg/day) DEEM-FClD DEEM-FCID

General U.S. Population 0

. 004720 12

All In fants(< I year old) 0.006718 17

Ch il d r en 1-2 

### years old 0.011869 30
C hildren 3-5 years old 0.008864 22

Children 6-12 years o ld 0.04 0.005336 1 3

Youth 1 3-19 years old 0.003402 8.5

Adults 20-49 years old 0.004100 10

Females 13

-49 years old 0.004197 10

Adults 50-99 years old 0.004501 II

0 0 

### I The populatiOn with the h1ghest exposure 1s m bold



## VIII. Characterization of Inputs/Outputs

The chronic dietary exposure analysis is considered to be conservative since it uses tolerancelevel residues and 100% cro p treated. As a resu lt, HED is confident that exposure is not underestimated to the U.S. population or any population subgroup. Further refi nements could be**made~** 

### however, they are not necessary at the present time.



## IX. Conclusions

The chronic dietary exposure assessment was a conservative assessment, conducted using tolerance-level residues and 100% crop tre ated. Estimated concentrations of flonicarnid in drinking water from the proposed uses were provided by EFED and incorporated directly into the chronic assessments.

The chronic dietary (food and drinking water) exposure to flonicamid is below HED's level of

concern for the general U.S. population and all population subgroups. The chronic dietary exposure estimates are 12% cPAD for the general U.S. population and 30% cPAD fo r children 1- 2 years old, the mo s t highly exposed population sub gro up.



## X. List of Attachments

Attachment 1 : Chronic Residue Input File. Attachment 2: Chron ic Results File.

Page 7 of 13Flonicamid Dietary Exposure Assessment DP Barcode: 0413405



### Attachment 1 : C hro nic Res idue Input F ile

Filename: C:\Documents and Settings\NDODD\My Documents\DEEM Version 3.16\Flonicamid\FLONICAMID081413.R08 Chemical : FLONICAMID RfD(Chronic): .04 mg/kg bw/day NOEL(Chroni c): 4 mg/kg bw/day RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 08

- 14 -201 3 /1 6:45:00 Program ver. 3.16, 03-08

- d Comment: CHRONIC ONLY

Crop EPA Code Grp Commodity Name

0101050000 lAB 0101050 001 lAB 0101067000 lAB 0101078000 l AB 010107800 1 l AB 0101079000 lAB 0101084000 lAB 0101100000 l AB 0101168000 l AB 0101190000 lAB 0101250000 lAB 0101251000 lAB 0101 251001 lAB 0101 314000 lAB 0101316000 lAB 0101327000 l AB 0101331000 l AB 0101388000 lAB 0103015000 lCD 01030 1 500 1 l CD 0103017000 lCD 0103082000 lCD 010308200 1 lCD 0103139000 lCD 0103166000 1CD 010316600 1 1CD 0103167000 lCD 0103296000 1C 0103297000 1C 0103297001 1C 0103298000 lC 010329800 1 l C 0103299000 l C 010329900 1 l C 0103300000 lC 010330000 1 l C 0103366000 1CD 0103366001 lCD 0103371000 1CD 0103387000 lCD 0103406000 lCD 0103407000 lCD 0200315000 2 0 401005000 4A 0401018000 4A 040110400 0 4A 0401133000 4A 0401134000 4A 0401138000 4A 0401150000 4A 0401204000 4A 0401205000 4A 0 401248000 4A 0401313000 4A Beet, garden, roots Beet, garden, roots

- babyfood Burdock Carrot Carrot-babyfood Carrot, juice Celeriac Chicory, roots Ginseng, dried Horseradish Pars ley, turnip rooted Parsnip Parsnip-baby food Radish, roots Radish, Oriental, roots Rutabaga Salsify, roots Turnip, roots Arrowroot, flour Arrowroo t, flour

- babyfood Artichoke, Jerusalem Cassava Cassava-babyfood Dasheen, corm Ginger Ginger-babyfood Ginger, dried Potato, chips Potato, dry (granules/ flakes) Potato, dry (granules/ flakes) -b Potato, flour Potato, flour-babyfood Potato, tuber, w/peel Potato, tuber, w/peel

- babyfood Potato, tuber, w/o peel Potato, tuber, w/o peel-babyf ood Sweet potato Sweet potato-baby food Tanier, corm TUrmeric Yam, true Yam bean Rad ish, tops Amaranth, leafy Arugula Chrysanthemum, garland Cress, garden Cress, upland Dandelion, leaves Endive Lettuce, head Lettuce, leaf Parsley, leaves Radicchio Def Res (ppm)

0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.200000 0

. 200000 0.200000 0.200000 0.200000 0.200000 0.200000 0.200000 0.200000 0.200000 0.400000 0.400000 0.400000 0.400000 0.200000 0.200000 0.200000 0.200000 0.200000 0.200000 0.200000 0.200000 0.200000 0.200000 16.000000

4.000000 4.000000 4.000000 4.000000 4.000000 4.000000 4.000000 4 .000000 4 .000000 4.000000 4.000000



## Page 8 of 1 3 Adj.Factors #1 #2

1 .000 1 .000 1

. 000 1

. 000 1.000 1 .000 1

. 000 1.000 1.000 1

. 000 1.000 1.000 1.000 1.000 1.000 1.000 1. 000 1.000 1 .000 1. 000 1.000 1.000 1.000 1 .0 00 1.000 1. 000 1.000 1.000 1.000 1

. 000 1.000 1.000 1 .000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1 .000 1 .000 1.000 1.000 1.000 1.000 1.000 1.000 1

. 000 1. 000 1. 000 1.000 1.000 1.000 1.000 1

. 000 1.000 1.000 1.000 1

. 000 1.000 1.000 1.000 1. 000 1 .000 1.000 1.000 1. 000 1.000 1.000 1.000 1 .0 00 1.000 1.000 1.000 1.000 1.000 1. 000 1.000 1.000 1.000 1.000 1 .000 1.000 1.000 1.000 1.000 1. 000 1.000 1.000 1. 000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 CommentFlonicamid Dietary Exposure Assessment DP Barcode : 0 413 405

04013SSOOO 4A Spinach 04013SS001 4A Spinach-babyfood 040 2 076000 4B Cardoon 04020SSOOO 4B Celery 04020SS001 4B Celery

- babyfood 04020S6000 4B Celery, juic e 04020S7000 4 B Celcuce 04021S2000 4B Fennel, Florence 0402322000 4B Rhubarb 0402367000 4B Swiss ch a rd OS01061000 SA Broccoli OS01061001 SA Broccoli-babyf ood OS0106 2 000 SA Broccoli
, Chinese OS01064000 SA Brussels sprouc s OS0 1 069000 S A Cabbage OS01071000 S A Cabbage, Chinese, napa OS010 72 000 S A Cabba ge, Chinese
, mustard OS010S3000 SA Cauliflower OS0 11 96000 SA K oh lrabi OS020 63000 SB Broccol i raab 0502070000 5B Cabbage, Chinese, bok choy 0 502117000 5B Co lla r ds 0502194000 5B Kale 0502229000 5B M ustard greens OS0231SOOO 5B Rape greens OS023S9000 5B Turnip, greens OS0137 4 000 SA Tomatillo OS01375000 SA Tomato OS0137S001 SA Toma to

- babyfood OS01376000 SA OS01376001 SA Toma co, paste Tomato, paste-babyfood OS01377000 SA Toma to, puree OS01377001 SA Toma to, puree

- babyfood OS0137SOOO SA Tomat o, dried OS0137S001 SA Toma to, dried-baby f ood OS01379000 SA Toma to, juice OS013SOOOO SA Tomato , Tree OS0214SOOO SBC Eggplant OS02234000 SBC Okra OS02270000 SB Pepper, bell OS02270001 SB Pepper, bell

- babyfood OS02271000 SB Pepper, bell, dried OS02271001 SB Pepper, b e ll, dried

- babyfood OS02272000 SBC Pepper, nonbell OS02 272 00 1 SBC Pepper, nonbe ll- babyfood OS02273000 SBC Pepper, nonbell, dried 090 10 75000 9A Cant a loupe 09011S7000 9A Honeydew m e lon 0901399000 9A Wa t erme lon 0901400000 9A W aterme l on, juice 0902021000 9B Balsam pear 0 9020SSOOO 9B C h ayote, frui t 0902102000 9B C h i n ese waxgourd 0902135000 9B Cu c umber 090230SOOO 9B Pump k in 0902309000 9B Pumpkin, seed 0902356000 9B Squash, summer 09023S6001 9B Squash, summer

- babyfood 09023S7000 9B Squash, winter 09023S7001 9B Squash, winter-babyfood 1100007000 11 Apple, fruit with peel 110000SOOO 11 Apple, peeled fruit 110000S001 11 Apple, peeled fruit

- babyfood 1100009000 11 Apple, dried 1100009001 11 Apple, dried

- babyfood 11000 1 0000 11 Apple
,**JU~ce** Full comment: 03293S1 1100010001 11 App l e , juice

- babyfood 1100011000 11 Apple, sauc e 9

. 000000 9.000000 4.000000 4.000000 4.000000 4.000000 4.000000 4.000000 4.000000 4.000000 1.500000 1 .500000 1.SOOOOO 1.5 00000 1. 500 000 1.5000 00 1

. 500000 1.500000 1. 500000 16. 000000 1 6.000000 16.000 000 16.000000 16.000000 1 6.000000 1 6.000000 0.400000 0 .4 00000 0. 4 00000 1.000 1.0 00 1. 000 1. 000 1. 000 1. 000 1.000 1. 000 1.000 1. 000 1.000 1. 000 1.000 1. 000 1.000 1. 000 1.000 1. 000 1. 000 1. 000 l. 000 1. 000 l. 000 1. 000 1. 000 1. 000 1 .000 1.000 1.000 1 .000 l. 000 1. 000 1.000 1.000 1.000 1.000 1. 00 0 1. 000 1 .000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1.000 1.000 l. 000 1. 000 1. 000 1. 000 1. 000 1. 000 l. 000 1

. 000 1. 000 l. 000 2.000000 1.000 1.000 2.000000 1.000 1.000 0.500000 1.000 1.000 0.500000 1.000 1.000 0.400000 14.300 1.000 0. 4 00000 14.300 1.000 0.400000 1.500 1.000 0.400000 1.000 1.000 0.400000 1.000 1.000 0 .4 00000 1.000 1.000 0 .40 0000 1.000 1. 000 0 .40000 0 1

. 000 1.000 0. 4 00000 1.000 1.000 0.400000 1.000 1 .000 0. 4 00000 1 .000 1 .000 0.40000 0 1 .000 1.000 0. 4 00000 1

. 000 1 .000 1 .SOOOOO 1.000 1 .000 1.500000 1.000 1. 000 1

. 500000 1.000 1. 000 1 .SOOOOO 1.000 1 .000 1 .500000 1.000 1 .000 1

. SOOOOO 1 .000 1.0 00 1.500000 1.000 1. 000 1 .SOOOOO 1.0 00 1.000 1 .SOOOOO 1.000 1 .000 1.5 00000 1.000 1.000 1.500000 1.000 1.000 1 .500000 1

. 000 1.000 1

. 500000 1.000 1.000 1.SOOOOO 1.000 1.000 0

. 200000 1.000 1 .000 0.200000 1.000 1.000 0.200000 1

. 000 1.000 0.200000 

### s.ooo 1.000 0.200000 

### s.ooo 1.000 0

. 200000 1.000 1 .000 03293S

0

. 200000 1.000 1. 000 0

. 200000 1

. 00 0 1 .000



## Page 9 of 13

### Flo nicam id Di etary Exposure Assess m ent

1100011001 11 1100129000 11 1100173500 11 1100210000 11 1100266000 11 1100266001 11 1100267000 11 1100268000 11 110026800 1 11 1100310000 11 1201090000 12A 1201090001 12A 1201091000 12A 1201091001 12A 1202012000 128 1202012001 128 1202013000 1 28 12020 14 000 128 120201400 1 1 28 1 202230000 12B 1202260000 12 8 Apple, sauce-babyfood Crabapple Goji berry Loqua t Pear Pear

- babyfood Pear, dried Pear, juice Pear, juice

- babyfood Quince Cherry Cherry-babyfood Cherry, JUl.ce Cherry, juic e-babyfood Apricot Apricot-babyfood Apricot, dried Apricot, juice Apricot, juice-babyfood Nectarine Peach 1202260001 12 B Peach

- babyfood 1202261000 12B Peach, dried 1202261001 12B Peach, dried-babyfood 12022 62000 12 B Peach, juice 1202262001 12B Peach, juice-babyfood 1203285000 12C Plum 1203285001 12C Plum -babyfood 12032 86000 12C Plum, prune, fresh 120328600 1 1 2C Plum, prune, fresh-babyfood 1203287000 12C Plum, prune, dr ied Full comment: 0290386 1203287001 12C Plum, prune, dr i ed -babyfood 1203288000 12C Plum, prune, ju i ce 1203288001 12 C Plum, prune, juic e-baby food 1307130000 13G Cranberry 1307130001 13G Cranberry

- babyfood 1307131000 13G Cranberry, dried 1307132000 13G Cranberry, juice 13071 32001 13G Cranberry, juice

- babyfood 1307359000 13G Strawberry 1307359001 13G Strawberry-babyfood 1307360000 13G Strawberry, JU l.ce 130736000 1 1 3G Strawberry, juice

- babyfood 1400003000 14 Almond 140000300 1 14 Almond-babyfood 1400004000 1 4 Almond, oi l 140000400 1 14 Al m ond, oil -b abyfood 1400059000 1 4 Braz il nut 1400068000 1 4 Butternut 1400081000 1 4 1400092000 14 1400155000 14 1400156000 14 1400185000 14 1400213000 14 1400269000 14 1400278000 14 140028200 0 14 1400391 000 14 18 00002000 1 8 200 1163000 2 0 A 2001319000 20A 20013 1 900 1 20A 2001336000 20A 200133600 1 2 0A 2001337000 20A 2001337001 20A 2003128000 20C Cashew Chestnut Hazelnut Hazelnut, oil Hickory nut Macadamia nut Pecan Pine nut Pistachio Walnut Alfalfa, seed F l ax seed, oil Rapeseed, oil Rapeseed, oil

- babyfood Sesame, seed Sesame, seed-babyfood Sesame, oil Sesame, oil-babyfood Cottonseed, oil 0.200000 0.200000 0.400000 0.200000 0.200000 0

. 200000 0.200000 0.200000 0.200000 0.200000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000 0.600000

0.600000 0.600000 0.600000 1.500000 1 .500000 1.500000 1.500000 1.500000 1.500000 1.500000 1.500000 1.500000 0.150000 0.150000 0.150000 0

. 150000 0.150000 0.150000 0.150000 0.150000 0.150000 0.150000 0.150000 0.150000 0.150000 0.150000 0.150000 0.150000 1

. 500000 1.500000 1.500000 1.500000 1.500000 1.500000 1 .500000 1.500000 0.500000



### Page 10 of 13 1.000 1.000 1. 000 1.000 1.00 0 1 .000 6.250 1.000 1 .000 1 .000 1.000 1. 000 1.500 1.500 1.000 1.000 6.000 1.000 1.000 1 .0 00 1 .000 

### DP Barcode: 0413405

1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1. 000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1 .000 1.000 1.000 1.000 7.000 1.000 7

. 000 1. 000 l. 000 1. 000 1. 000 1. 000 1.000 1. 000 1.000 1. 000 1.000 1. 000 1. 000 1. 000 1.000 1.000 029038

1. 000 1. 000 1. 400 1. 000 1.400 1. 000 l. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 100 1. 000 1.100 1. 000 1.000 l. 000 1.000 1.000 1. 000 1. 000 1.000 1.000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1 .00 0 1.000 1

. 000 1.000 1. 000 1. 000 1. 000 1.000 1.000 1.000 1.000 1.000 1. 000 1 .000 1.000 1.000 1.000 1 .000 1

. 000 1.000 1

. 000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.00 0 1.000 1.000 1.000 1.000 1

. 000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000

### Flonicamid Dietary Exposure Assessment

2003128001 20C Cottonseed, oil

- babyfood 0.500000 0.080000 0.080000 0.080000 0.080000 0.080000 0.030000 0.030000 0.080000 0.080000 0.080000 0

. 080000 0.080000 0.030000 0.080000 0.080000 0

. 080000 0 .0 300 00 0.030000 0 .030000 0.030000 0

. 030000 0

. 030000 0.030000 0.030000 0.030000 0.080000 0

. 080000 0.080000 0.030000 0.030000 0.080000 0.080000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.050000 0.030000 0.030000 0

. 030000 0

. 030000 0

. 03000 0 0.030000 0

. 030000 0

. 030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.040000 0.040000 0.040000 0

. 040000 0.040000 3100044000 31 3100044001 31 3100045000 31 3100046000 31 3100046001 31 310004 7000 31 3100047001 31 3100048000 31 3100049000 31 310004 9001 31 3200169000 32 3200170000 32 3200171000 32 3200172000 32 3200173000 32 3300189000 33 3400290000 34 3400290001 34 3400291000 34 3400292000 34 3400292001 34 3400293000 3 4 3400293001 3 4 3400294000 34 3400295000 34 3500339000 35 3500339001 35 3500340000 35 3500341000 35 3500341001 35 3500342000 35 3500343000 35 3600222000 36 3600222001 36 3600223000 36 3600223001 36 3600224000 36 3600224001 36 3600225001 36 4000093000 40 4 000093001 40 4000094000 40 4 000095000 40 4 000095001 40 4000096000 40 400009600 1 40 4000097000 40 400009700 1 40 5000382000 50 5000382001 50 5000383000 50 5000383001 50 500038 4 000 50 5000384001 50 5000385000 50 5000385001 50 5000386000 50 5000386001 50 6000301000 60 6000302000 60 6000303000 60 600030 4 000 60 6000305000 60 7000145000 70 7000145001 70 7000146000 70 7000146001 70 7000147000 70 Beef, meat Beef, meat-baby food Beef, meat, dried Beef, meat byproducts Beef, meat byproducts

- babyfood Beef, fat Beef, fat -babyfood Beef, kidney Beef, liver Beef, live r -baby food Goat, meat Goat, meat byproducts Goa t, fat Goat, k idney Goat, liver Horse, meat Pork, meat Pork, meat-babyfood Pork, skin Pork, meat byproducts Pork, meat byproducts-babyfood Pork, fat Pork
, f a t -babyfood Pork, k idn ey Pork
, live r Sheep
, meat Sheep, meat -babyfood Sheep, meat byproducts Sheep, fat Sheep, fat -bab yfood Sheep, kidney Sheep, live r Milk, fat Milk, fat-baby food/i nfant formu Milk, nonfat solids Milk, nonfat solids-baby f ood/in Milk, water Milk, water-babyfood/infant form M

ilk, sugar ( lactose l -baby food/ Chicken, mea t Chicken, m eat-babyfood Chicken, liver Chicken, meat byproduc t s Ch icke n, meat byp r oducts

- babyfoo Chicken, fat Chic ken, fat-babyfood Chicken, skin Chicken, skin

- baby food Turkey, meat Turkey, meat-babyfood Turkey, li ve r Turkey, liv er-babyfood Turkey, meat byproducts Turkey, meat byproducts-babyfood Turkey, fat Turkey, fat-babyfood Turkey, skin Turkey, skin-babyfood Poultry, other, m eat Poultry, other, liver Poultry, other, m ea t byproducts Poultry, othe r , fat Poultry, o ther
, skin Egg, whole Egg, whole

- babyfood Egg, white Egg, white (solids)-babyfood Egg, yolk



## Page 11 of 13 DP Barcode: 0413405

1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 920 1. 000 1. 000 1. 000 1. 000 1. 000 1.000 1. 000 1.000 1.000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1

. 000 1. 000 1.000 1.000 1.000 1.000 1. 000 1. 000 1

. 000 1. 000 1.000 1. 000 1.000 1. 000 1.000 1. 000 1. 000 1. 000 1.000 1.0 00 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1.000 1.000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1.000 1 .000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1. 000 1.000 1.000 1.000 1.000

### Flonicamid Dietary Exposure Assessment DP Barcode: 0413405

7000147001 70 Egg, yolk-babyfood 0.0 4 0000 1.000 1.000 8601000000 86A Water, direct, all sources 0.009920 1.000 1.000 8602000000 86B water, indirec t, all sources 0.009920 1. 000 1. 000 9500188000 0 Hop 7.000000 1.000 1.000 9500275000 0 Peppermint 7.00000 0 1.0 00 1.000 9500276000 0 Peppermint, oil 7.000000 1. 000 1.000 9500352000 0 Spea r mint 7 .000000 1. 0 0 0 1

. 000 9500353000 0 Spearmint, oil 7 .000000 1. 000 1 .000



### Page l 2of 13F l o ni cami d D ietarv Exp osure Assess me nt D P Barcode: 04 1 3 4 0 5



### Attachm ent 2: C hro nic Res ul ts File

U.S. EPA Ver. 3 .16, 03-08-d DEEM-FC I D Chroni c a nalysis for FLONICAM I D NHANES 2 003

- 2009 2-day Residue f i l e name: C:\Documents a n d S e tting s\NDODD\ M y Documen ts\DEEM Version 3.16\ Fl o n i cami d \ FLONICAMID 081 4 1 3

. R0 8 A dj u st m

e nt f a ctor #2 used. Analysis D ate 08

- 1 4- 2013/16:46:44 Res i due file date d : 08

- 14 -2 0 1 3/16:45:00 Refere nc e d o se (RfD, Chronic) 

### = .04 mg/kg bw/day COMM ENT 1 : CH RONIC ONLY

Total exposure by population subgroup

Total Exposure

Population

Subgroup

T otal U S Popu l a tion Hispanic Non-His p-White Non-Hi s p- B l a c k Non-Hi s p-Oth e r Nursing Infants Non

- Nursing Infants Female 13+ PREG Children 1

- 6 Children 7-12 M

ale 13- 1 9 Female 1 3- 1 9/NP M

ale 20+ Femal e 20+/N P Seniors 55 + All I n fan t s Fema l e 13

- 50 Children 1

- 2 Chi l dren 3-5 Children 6-12 Youth 13

- 19 Adults 20

- 49 Adults 50-99 Female 1 3- 4 9 mg/kg b ody wt/day

0

. 00 4 720 0

. 004361 0

. 004699 0.004800 0.005763 0.004491 0.007712 0.004405 0.009643 0.005018 0.003354 0.003453 0.003925 0.004575 0.004497 0.006718 0.004185 0. 011869 0.008864 0.005336 0.003402 0. 004100 0.004501 0.004197



### Page 1 3 o f 13 P e rcent of Rfd

11. 8% 10.9% 1 1.7% 12.0% 14.4% 11.2% 19.3% ll.Ot 24 .lt 12.5t

8.4% 8.6t 9.8t 11.4% 11.2t 16

. 8t 10.5% 29. 7t 22.2t 13.3%

8.5t 10.3t 11.3% 10.5t