19300 Federal Register / Vol. 77, No. 62 / Friday, March 30, 2012 / Notices 

may enable clinicians to effectively 

stratify patients for more aggressive 

cancer treatment and prioritize 

candidates for liver transplantation. 

Potential Commercial Applications: 

• Method to diagnose HCC 

• Method to prognose patient survival 

• Method to stratify HCC for 

appropriate treatment 

• Method to treat HCC 

Competitive Advantages: 

• Retrospective studies performed on 

human samples 

• Modulation of SCD–1 reduces 

HpSC HCC characteristics 

Development Stage: 

• Early-stage 

• In vitro data available 

• In vivo data available (human) 

Inventors: Anuradha Budhu and Xin 

W. Wang (NCI). 

Intellectual Property: HHS Reference 

No. E–205–2011/0—U.S. Provisional 

Application No. 61/533,392 filed 12 Sep 

2011. 

Related Technology: HHS Reference 

No. E–139–2010/0—PCT Application 

No. PCT/US2011/032285 filed 13 Apr 

2011. 

Licensing Contact: Jennifer Wong; 

301–435–4633; wongje@mail.nih.gov. 

Collaborative Research Opportunity: 

The National Cancer Institute is seeking 

statements of capability or interest from 

parties interested in collaborative 

research to further develop, evaluate or 

commercialize biomarkers for liver 

cancer. For collaboration opportunities, 

please contact John Hewes, Ph.D. at 

hewesj@mail.nih.gov. 

Potential Use of Anti-IgE in the 

Treatment of Lupus Nephritis 

Description of Technology: Systemic 

lupus erythematosus (SLE) is a multiorgan inflammatory disease 

characterized by a significant morbidity 

and mortality related to both disease 

evolution as well as therapeutic side 

effects. At least half of SLE patients 

develop lupus nephritis. 

The inventors have used a Lyn -/- 

mouse model that develops an 

autoimmune disease exhibiting some 

features of human SLE. Using this 

model the inventors identified basophils 

and self-reactive IgEs as important 

components in the development of 

autoantibody-mediated kidney disease. 

The inventors found that depletion of 

basophils or the absence of IgE causes 

a considerable reduction in 

autoantibody production and preserves 

kidney function in the Lyn -/- mice. The 

inventors’ work demonstrates that IgE 

immune complexes can activate 

basophils and that removal of selfreactive IgEs that form functional 

circulating immune complexes prevents 

kidney disease. Further, the inventors 

have shown that basophils are 

contributors to the production of the 

self-reactive antibodies that cause 

lupus-like nephritis in the Lyn -/- mice. 

Accordingly, reducing circulating IgE 

levels or reducing basophil activation 

may be of therapeutic benefit. 

Potential Commercial Applications: 

Further research and development of 

therapeutic approach to treat lupus 

nephritis. 

Competitive Advantages: Current 

treatment of lupus has not advanced for 

many years. This finding is of 

importance for its potential in 

advancing treatment of the disease. 

Development Stage: 

• Early-stage 

• Pre-clinical 

Inventors: Juan Rivera and Nicolas 

Charles (NIAMS). 

Publications: 

1. Charles N, et al. Basophils and the 

T helper 2 environment can promote the 

development of lupus nephritis. Nat 

Med. 2010 Jun;16(6):701–707. [PMID 

20512127]. 

2. Brightbill HD, et al. Antibodies 

specific for a segment of human 

membrane IgE deplete IgE-producing B 

cells in humanized mice. J Clin Invest. 

2010 Jun;120(6):2218–2229. [PMID 

20458139]. 

3. Mack M, et al. Basophils and mast 

cells in renal injury. Kidney Int. 2009 

Dec;76(11):1142–1147. [PMID 

19692999]. 

4. Busse W, et al. Omalizumab, antiIgE recombinant humanized monoclonal 

antibody for the treatment of severe 

allergic asthma. J Allergy Clin Immunol. 

2001 Aug;108(2):184–90. [PMID: 

11496232]. 

Intellectual Property: HHS Reference 

No. E–216–2010/0—PCT Application 

No. PCT/US2010/058077 filed 24 Nov 

2010. 

Licensing Contact: Jaime M. Greene; 

301–435–5559; 

greenejaime@mail.nih.gov. 

Collaborative Research Opportunity: 

The National Institute of Arthritis and 

Musculoskeletal and Skin Diseases is 

seeking statements of capability or 

interest from parties interested in 

collaborative research to further 

develop, evaluate or commercialize the 

technology for the use of anti-IgE in the 

treatment of Lupus Nephritis. For 

collaboration opportunities, please 

contact Cecilia Pazman at 

pazmance@mail.nih.gov. 

Dated: March 27, 2012. 

Richard U. Rodriguez, 

Director, Division of Technology Development 

and Transfer, Office of Technology Transfer, 

National Institutes of Health. 

[FR Doc. 2012–7709 Filed 3–29–12; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HOMELAND 

SECURITY 

[Docket No. DHS–2012–0012] 

National Infrastructure Advisory 

Council 

AGENCY: National Protection and 

Programs Directorate, DHS. 

ACTION: Committee Management; Notice 

of an open Federal Advisory Committee 

meeting. 

SUMMARY: The National Infrastructure 

Advisory Council (NIAC) will meet on 

Tuesday, April 17, 2012, 1310 N. 

Courthouse Road, Suite 300, Virginia 

Room, Arlington, VA 22201. The 

meeting will be open to the public. 

DATES: The NIAC will meet Tuesday, 

April 17, 2012, from 1:30 p.m. to 4:30 

p.m. The meeting may close early if the 

committee has completed its business. 

For additional information, please 

consult the NIAC Web site, 

www.dhs.gov/NIAC, or contact the NIAC 

Secretariat by phone at (703) 235–2888 

or by email at NIAC@dhs.gov. 

ADDRESSES: 1310 N. Courthouse Road, 

Suite 300, Virginia Room, Arlington, VA 

22201. 

While this meeting is open to the 

public, participation in the NIAC 

deliberations is limited to committee 

members and appropriate Federal 

Government officials. Discussions may 

include committee members, 

appropriate Federal Government 

officials, and other invited persons 

attending the meeting to provide 

information that may be of interest to 

the Council. 

Immediately following the committee 

member deliberation and discussion 

period, there will be a limited time 

period for public comment. Comments 

should be limited to meeting agenda 

items and previous NIAC studies. All 

previous NIAC studies can be located at 

www.dhs.gov/NIAC. Relevant public 

comments may be submitted in writing 

or presented in person for the Council 

to consider. Comments should be 

limited to the issues and topics 

addressed by the Council. In-person 

presentations will be limited to three 

minutes per speaker, with no more than 

30 minutes for all speakers. Parties 

interested in making in-person 

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Federal Register / Vol. 77, No. 62 / Friday, March 30, 2012 / Notices 19301 

comments should register no fewer than 

15 minutes prior to the beginning of the 

meeting at the meeting location. Oral 

comments will be permitted based upon 

the order of registration; all registrants 

may not be able to speak if time does 

not permit. Written comments may be 

sent to Nancy Wong, Department of 

Homeland Security, National Protection 

and Programs Directorate, 245 Murray 

Lane SW., Mail Stop 0607, Arlington, 

VA 20598–0607. It is recommended that 

written comments be received by Nancy 

Wong no later than April 6, 2012, 

identified by Federal Register Docket 

Number DHS–2012–0012 for 

consideration by the NIAC members 

prior to the meeting. Written comments 

provided after April 6, 2012, will still be 

accepted and reviewed by the members. 

Comments may also be submitted by 

any one of the following methods: 

• Federal eRulemaking Portal: 

www.regulations.gov. Follow the 

instructions for submitting written 

comments. 

• Email: NIAC@dhs.gov. Include the 

docket number in the subject line of the 

message. 

• Fax: 703–603–5098. 

• Mail: Nancy Wong, National 

Protection and Programs Directorate, 

Department of Homeland Security, 245 

Murray Lane SW., Mail Stop 0607, 

Arlington, VA 20598–0607. 

Instructions: All written submissions 

received must include the words 

‘‘Department of Homeland Security’’ 

and the docket number for this action. 

Written comments received will be 

posted without alteration at 

www.regulations.gov, including any 

personal information provided. 

Docket: For access to the docket to 

read background documents or 

comments received by the NIAC, go to 

www.regulations.gov. 

FOR FURTHER INFORMATION CONTACT: 

Nancy Wong, National Infrastructure 

Advisory Council Designated Federal 

Officer, Department of Homeland 

Security, telephone (703) 235–2888. 

SUPPLEMENTARY INFORMATION: Notice of 

this meeting is given under the Federal 

Advisory Committee Act, 5 U.S.C. App. 

(Pub. L. 92–463). The NIAC shall 

provide the President through the 

Secretary of Homeland Security with 

advice on the security of the critical 

infrastructure sectors and their 

information systems. 

The NIAC will meet to address issues 

relevant to the protection of critical 

infrastructure as directed by the 

President. At this meeting, the 

committee will receive a presentation 

from the NIAC Working Group 

regarding the scope of the next phase of 

the Working Group’s critical 

infrastructure resilience study, which 

incorporates a regional perspective. 

Meeting Agenda 

I. Opening of Meeting 

II. Roll Call of Members 

III. Opening Remarks and Introductions 

IV. Approval of January 10, 2012, Minutes 

V. NIAC Deliberation and Recommendation 

on Scope of Next Study on Critical 

Infrastructure Resilience incorporating a 

regional perspective 

VI. Public Comment: Discussion Limited to 

Meeting Agenda Items and Previous 

NIAC Studies 

VII. Closing Remarks 

Information on Services for Individuals 

With Disabilities 

For information on facilities or 

services for individuals with disabilities 

or to request special assistance at the 

meeting, contact the NIAC Secretariat at 

(703) 235–2888 as soon as possible. 

Dated: March 26, 2012. 

Nancy J. Wong, 

Designated Federal Officer for the NIAC. 

[FR Doc. 2012–7695 Filed 3–29–12; 8:45 am] 

BILLING CODE 9110–9–P 

DEPARTMENT OF HOMELAND 

SECURITY 

Coast Guard 

[USCG–2012–0099] 

Prince William Sound Regional 

Citizens’ Advisory Council Charter 

Renewal 

AGENCY: Coast Guard, DHS. 

ACTION: Notice of recertification. 

SUMMARY: The purpose of this notice is 

to inform the public that the Coast 

Guard has recertified the Prince William 

Sound Regional Citizens’ Advisory 

Council (PWSRCAC) as an alternative 

voluntary advisory group for Prince 

William Sound, Alaska. This 

certification allows the PWSRCAC to 

monitor the activities of terminal 

facilities and crude oil tankers under the 

Prince William Sound Program 

established by statute. 

DATES: This recertification is effective 

for the period from March 1, 2012 

through February 28, 2013. 

FOR FURTHER INFORMATION CONTACT: 

LCDR Mike Franklin, Seventeenth Coast 

Guard District (dpi), by phone at (907) 

463–2821, email 

Michael.R.Franklin@uscg.mil or by mail 

at P.O. Box 25517, Juneau, Alaska 

99802. 

SUPPLEMENTARY INFORMATION: 

Background and Purpose 

As part of the Oil Pollution Act of 

1990, Congress passed the Oil Terminal 

and Oil Tanker Environmental 

Oversight and Monitoring Act of 1990 

(the Act), 33 U.S.C. 2732, to foster a 

long-term partnership among industry, 

government, and local communities in 

overseeing compliance with 

environmental concerns in the 

operation of crude oil terminals and oil 

tankers. 

On October 18, 1991, the President 

delegated his authority under 33 U.S.C 

2732(o) to the Secretary of 

Transportation in Executive Order 

12777, section 8(g) (see 56 FR 54757; 

October 22, 1991) for purposes of 

certifying advisory councils, or groups, 

subject to the Act. On March 3, 1992, 

the Secretary redelegated that authority 

to the Commandant of the USCG (see 57 

FR 8582; March 11, 1992). The 

Commandant redelegated that authority 

to the Chief, Office of Marine Safety, 

Security and Environmental Protection 

(CG–5) on March 19, 1992 (letter #5402). 

On July 7, 1993, the USCG published 

a policy statement, 58 FR 36504, to 

clarify the factors that shall be 

considered in making the determination 

as to whether advisory councils, or 

groups, should be certified in 

accordance with the Act. 

The Assistant Commandant for 

Marine Safety and Environmental 

Protection (CG–5), redelegated 

recertification authority for advisory 

councils, or groups, to the Commander, 

Seventeenth Coast Guard District on 

February 26, 1999 (letter #16450). 

On September 16, 2002, the USCG 

published a policy statement, 67 FR 

58440, that changed the recertification 

procedures such that applicants are 

required to provide the USCG with 

comprehensive information every three 

years (triennially). For each of the two 

years between the triennial application 

procedure, applicants submit a letter 

requesting recertification that includes a 

description of any substantive changes 

to the information provided at the 

previous triennial recertification. 

Further, public comment is not solicited 

prior to recertification during 

streamlined years, only during the 

triennial comprehensive review. 

On March 1, 2003, the Coast Guard 

was transferred from the Department of 

Transportation (DoT) to the Department 

of Homeland Security (DHS) and 

retained the previous delegations that 

were provided while it was in the DoT. 

The Alyeska Pipeline Service 

Company pays the PWSRCAC $2.9 

million annually in the form of a 

longterm contract. In return for this 

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