Exhibit 10.4.6

 



Addendum of   Unprotected Lease Agreement dated March 27, 2014 Made and executed in Tel   Aviv on the [handwritten: 15th] day of December, 2019 Between: Ogen Yielding   Real Estate Ltd., Company No. 520033093 Of 3 Har Sinai St., Tel Aviv   (Hereinafter: the "Lessor") The first party; And between: PolyPid   Ltd., Company No. 514105923 By its authorized signatories Of 18 HaSivim St.,   Petah Tikva (Hereinafter: the "Lessee") The second party; Whereas:   On March 27, 2014 the Lessee and the Lessor signed a lease agreement [hereinafter:   the "Original Agreement"] according to which the Lessee leases the   Leased Premises within their meaning in the Original Agreement; And whereas:   On July 1, 2014, July 23, 2017, November 28, 2017, January 22, 2018 and   November 4, 2018 the Lessor and the Lessee signed the Addenda of the Original   Agreement in connection with the Leased Premises [the Original Agreement and   Addenda thereof shall be referred hereinafter: the "Lease   Agreement"]; And whereas: The Lessee requested from the Lessor to increase   the area of the Leased Premises and lease an additional area of 55 sq.m.   gross (including a relative part in the public areas) on the ground floor in   the Tamar Building (hereinafter: the "Additional Area") and the   Lessor agreed to the request of the Lessee as said, and all in accordance   with and subject to the provisions set forth in this Addendum hereunder;   [Signed] Ogen Yielding Real Estate Ltd. PolyPid Ltd. 


    




 










2 Therefore, it   is Declared, Stipulated and Agreed between the Parties as Follows: 1.   Preamble 1.1. The preamble to this Addendum constitutes an integral part   hereof. 1.2. The entire definitions used in this Addendum shall have the   meaning assigned thereto in the Lease Agreement, except for the terms defined   in this Addendum differently and in conformance to the agreements set out in   herein. 1.3. The entire provisions set forth in the Lease Agreement shall   continue to be in full force and effect, mutatis mutandis, with the exception   of the provisions set forth in this Addendum in respect of which the parties   agreed that they shall take precedence over the provisions set forth in the   Lease Agreement. 1.4. The provisions set forth in this Addendum shall be   interpreted as adding to the provisions set forth in the Lease Agreement and   shall not derogate therefrom. 2. Definitions: 2.1. The Additional Area – an   area of approximately 55 sq.m. gross on the ground floor in the Tamar   Building, "Ogen Park" in HaSivim St., Petah Tikva, as stated in the   blueprint attached as Appendix A of this Addendum. 2.2. Basic index – the   consumer price index of September 2019 that was published on October 15,   2019. 3. Term of Lease of the Additional Area: 3.1. The Lessee leases from   the Lessor the Additional Area as of December 15, 2019 (hereinafter: the   "Lease Commencement Date") and until the expiration of the Term of   Lease set out in the Lease Agreement and Addenda thereof, i.e. until December   31, 2023 (hereinafter: the "Term of Lease of the Additional Area").   3.2. The Lessee declares that since it leases many areas in the Tamar   Building where the Additional Area is situated, it knows well the project and   the building where the Additional Area are situated, and that it inspected   the [Signed] Ogen Yielding Real Estate Ltd. PolyPid Ltd. 


    




 










3 physical   conditions, the legal status and the drawings and plans of the Additional   Area and found them to its satisfaction, and that it leases the Additional   Area in its condition at the time of signing this Addendum "AS-IS"   and the Lessee shall have no claim and/or suit in respect of the Additional   Area and/or condition thereof. 3.3. The Additional Area shall be added to the   area of the Leased Premises and shall constitute a part thereof for all   intents and purposes, unless otherwise stated expressly in this Addendum. 4.   Payment of the rent and management fees for the Additional Area: 4.1. Rent –   during the Term of Lease of the Additional Area the Lessee will pay to the   Lessor monthly rent in the amount of NIS 55 for each 1 sq.m. of the gross   area of the Leased Premises with the addition of linkage differentials to the   increase of the index, as of the Basic Index set out in this Addendum and up   to the index known on the payment date and with the addition of statutory   VAT. Notwithstanding the aforesaid, the Lessee shall be exempt from payment   of rent only for the following dates: December 15, 2019 – February 1, 2020   (hereinafter: the "Grace Period"). However, during the Grace Period   the Lessee shall be obligated to make all other payments as stated in the   Lease Agreement and in this Addendum in respect of the Additional Area such   as: management fees, municipal taxes, electricity and water. 4.2. Management   fees – during the Term of Lease of the Additional Area the Lessee will pay to   the Lessor monthly management fees in the amount of NIS 13 for each 1 sq.m.   of the gross area of the Leased Premises with the addition of linkage   differentials to the index as of the Basic Index set out in this Addendum and   up to the index known on the date of actual payment and with the addition of   statutory VAT. 4.3. Rent and management fees will be paid in the manner and   on the date set out for their payment in the Lease Agreement. 4.4. In   addition, the Lessee shall incur all other payments set out in the Lease   Agreement in respect of the Additional Area such as: municipal taxes,   electricity, water etc. [Signed] Ogen Yielding Real Estate Ltd. PolyPid Ltd. 


    




 










4 5. Insurance   and securities: 5.1. The Lessee will assure that the insurances that were   taken out in respect of the Leased Premises will also include the Additional   Area for the entire Term of Lease of the Additional Area. The Lessee will   provide the said insurances to the Lessor following its demand. 5.2. The   entire securities that were provided by the Lessee by virtue of the Lease   Agreement and Addenda thereof will also be used for the purpose of fulfilling   the undertakings of the Lessee in accordance with this Addendum. 6. General:   6.1.It is clarified that any breach of this Addendum by the Lessee shall   constitute breach of the Lease Agreement and the Lessor may seek the entire   reliefs set out in the Lease Agreement including Addenda thereof without   derogating from the rights of the Lessor in accordance with the provisions   set forth in this Agreement and/or in accordance with the provisions set   forth in any law. 6.2.In the event of discrepancy between the provisions of   the Lease Agreement and the provisions set forth in this Addendum the   provisions set forth in this Addendum shall take precedence. And in witness   hereof the parties are hereby undersigned: [Signature and Stamp: Ogen   Yielding Real Estate Ltd.] [Signature and Stamp: PolyPid Ltd. Amir Weisberg   CEO] The Lessor The Lessee [Signed] Ogen Yielding Real Estate Ltd. PolyPid   Ltd. 


    




 










5 [Signed] Ogen   Yielding Real Estate Ltd. PolyPid Ltd. 


    




 










6 [Signed] Ogen   Yielding Real Estate Ltd. PolyPid Ltd. [handwritten: addition of the area of   the ground floor in the Tamar Building for PolyPid 55 sq.m.]