Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 PC Code: 118602

______________________________________________________________________________________



### UNITED STATES ENVIRONMEN TAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF CHEMICAL SAFETY AND POLLUT ION PREVENTION



### MEMORANDUM

DATE: 28-June-2010

SUBJECT: Imazosulfuron : Acute and Chronic A ggregate Dietary (Food and Drinking Water) Exposure and Risk Assessments for the New Uses on Peppers, Rice, and Tomato

PC Code: 118602 DP Barcode: D367020 Decision No.: 406200 Registration No.: 59639-RLU, 59639-RLL, 59639-RAA Petition No.: 9F7535 Regulatory Action: Section 3 Registration Risk Assessment Type: Single Chemical Case No.: NA
TXR No.: NA CAS No.: 122548-33-8
MRID No.: NA 40 CFR: Pending

REVIEWER: Cassi L. Walls, Ph.D., Senior Biologist Risk Assessment Branch III/H ealth Effects Division (HED; 7509P)

THROUGH: Toiya Goodlow, Chemist Meheret Negussie, Chemist Dietary Exposure Science Advi sory Council (DESAC)/HED (7509P)

TO: Sheila Healy, Risk Assessor Risk Assessment Branch III/HED (7509P)

and

James Thompson, RM Team 25 Herbicide Branch/Registrat ion Division (RD; 7505P)

Executive Summary

Acute and chronic aggregat e dietary (food and drinking water) exposure and risk assessments were conducted for the herbicide, imazosulfuron, using the Dietary Exposure Evaluation Model (DEEM-FCIDTM), Version 2.03 which use food consumption data from the U.S. Department of Agriculture’s Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 1998. The analyses were performed to support

Page 1 of 14Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 PC Code: 118602

______________________________________________________________________________________ 

### a Section 3 Registration petition on peppers , rice, and tomatoes. Imazosulfuron is currently registered for use on turf grass and ornamentals. However, this is the first food/feed use request for imazosulfuron.

Acute Dietary Exposure Resu lts and Characterization

An unrefined dietary assessment was conducted assuming that 100% of crops with the requested uses of imazosulfuron are treated a nd that all treated crops contain residues at tolerance level. In addition, default proces sing factors were assu med for the requested crop uses. Potential residues in drinking water were includ ed in the analyses based on surface water results from the RICE model as these values were higher than the groundwater estimates from the Screening C oncentration in Ground Water (SCI-GROW) model (D362654 Faruque Khan, 13-MAY-2010). T hus, the results obtained from the present analyses may be considered hi ghly conservative. No population subgroups exceed HED’s level of concern at the 95 th 

### percentile of exposure for food and drinking water. The U.S. population occupied < 1% of the acute population-adjusted dose (aPAD), while the most highly exposed populat ion subgroup, all infants (< 1 year old), occupied 1.4% of the aPAD. For food alone , the U.S. population and the most highly exposed population subgroup, children 1-2 y ears old, both occupied < 1% of the aPAD

Chronic Dietary Exposure Re sults and Characterization

An unrefined chronic dietary assessment was conducted assuming that 100% of crops with the requested uses of imazosulfuron are treated and that all treated crops contain residues at tolerance level. In addition, de fault processing factors were assumed for the requested crop uses. Potential residues in drinking water we re included in the analyses based on surface water results from the RICE mo del as these values were higher than the groundwater estimates from the SCI-GROW model. No population subgroups exceed HED’s level of concern for dietary exposure from food and drinking water: the U.S. population occupied < 1% of the chronic population-adjusted dose (cPAD), while the most highly exposed population subgroup, all infa nts (< 1 year old), occupied 2.7% of the cPAD. No population subgroups exceed HED’s level of concern for dietary exposure from food alone: the U.S. population and the most highly exposed population subgroup, Children 1-2 years old, both occupied < 1% of the cPAD.

Cancer Dietary Exposure Re sults and Characterization

A determination of cancer risk was not perf ormed with DEEM-FCIDTM as part of the present assessment, since this chemical was cl assified as “Not likely to be Carcinogenic to Humans” based on negative genotoxicity and carcinogenicity in long term cancer studies in rats and mice. Therefore, a cancer dietary assessment for imazosulfuron is not required.

Page 2 of 14Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 PC Code: 118602

______________________________________________________________________________________


### I. Introduction

Dietary risk assessment incorpor ates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED ha s concluded will result in no unreasonable adverse health effects). This dose is refe rred to as the population- adjusted dose (PAD). The PAD is equivalent to point of depart ure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chroni c exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/E PA-PEST/2000/July/Day-12/6061.pdf ; or see SOP 99.6 (20-AUG-1999).

This is the first dietary assessment for imazo sulfuron as it is first food/feed use request.

II. Residue Information

Imazosulfuron is a new sulfonylurea herb icide being developed by Valent U.S.A Corporation for control of broad-leaf weeds and sedges. The mode of action of imazosulfuron is inhibition of the enzyme acetolactate synthase. Tolerances are requested for the residue of imazosulfuron (2-chloro- N -[[(4,6-dimethoxy-2- pyrimidinyl)amino]carbonyl]imidazo[1,2- α ]pyridine-3-sulfonamide) in/on peppers at 0.02 ppm; tomato at 0.02 ppm; and rice at 0.02 ppm. These tolerances were requested by Valent, as well as, recommended by HED.

The HED Residues of Concern Knowledge-bas ed Subcommittee (ROCKS) reviewed and discussed potato, rice, to mato, rotational crops, and livestock studies for the imazosulfuron, as well as toxicological and envi ronmental fate data, for determination of the residues of concern (19-MAY-2010). HE D has determined that the residue of concern in crop commodities for tolerance enforcement assessment is imazosulfuron, whereas, the residue of concern for risk a ssessment is the sum of imazosulfuron and its metabolite, 4,6-dimethoxy-2-ureidopyrimidin e (UDPM) (D377141, Edward Scollon, 01- JUNE-2010). Residue information for the proposed food commodities included in the present analyses was taken from the im azosulfuron residue chemistry memo (D367019, Stephen Funk, 06-JUNE-2010).

For both the acute and chronic dietary analys es, the recommended tolerances and default processing factors were used for each food co mmodity residue level. The acute and chronic assessments also assume that 100% of the crops are treated. Table 1 summarizes the imazosulfuron residue levels for the propos ed crops used in the acute and chronic dietary assessments.

Page 3 of 14Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 PC Code: 118602

______________________________________________________________________________________ Table 1. Summary of Imazosulfuron Residue Levels Used in Acute and Chronic Analyses. Matrix Residue Level [Acute and Chronic] (ppm)* Default Processing Factors

Pepper 0.04 Rice, grain 0.04
Tomato 0.04 Tomato paste = 5.4; Tomato puree = 3.3; Tomato, dried = 14.3; Tomato juice = 1.5 * The residue level of 0.04 ppm used in the assessments is the sum of the imazosulfuron proposed tolerance (0.02ppm) and its UDPM metabolite (0.02 ppm)



### III. Drinking Water Data

The drinking water residues used in the di etary risk assessment were provided by the Environmental Fate and Effects Divi sion (EFED) (D362654 Faruque Khan, 13-MAY2010). Water residues bolded in Table 2 were directly incorporated in the DEEM-FCID into the food categories “water, direct, all sources” and “water, indirect, all sources.”

Table 2. Tier I EDWCs for Imazosulfuron Applications

Drinking Water Source Model Use rate (lbs ai/A/year) Acute ( μ g/L) Chronic ( μ g/L)

Surface water RICE 0.3 278.9 278.9

Groundwater SCI-GROW 1.34 4.8 4.8



### Surface Water . The highest estimated drinking water concentration (EDWC) for imazosulfuron resulted from the Tier I RICE model. This recomm ended EDWC of 278.9

μ g/L is based on aerial spray application of 0.3 lbs. a.i./A per year for rice.

Groundwater . In lieu of sufficient groundwater monitoring data for imazosulfuron, the Tier 1 groundwater screening model SCI-GRO W was used to estimate concentration of imazosulfuron in groundwater source s. Turf grass applications with an annual use rate of 1.34 lbs ai/A/year was used in the modeling and resulted in a groundwater EDWC of 4.8

μ g/L.

Because the acute and chronic surface water estimates were higher than the groundwater estimates, the present analyses made use of the former values, expressed to two significant figures and converted into the proper units for the DEEM program (mg/L or ppm).

IV. DEEM-FCIDTM Program and Consumption Information

Imazosulfuron acute and chronic dietary exposure assessments were conducted using the DEEM-FCIDTM version 2.03 modeling software. It uses food consumption data from the U.S. Department of Agriculture (USDA) CSFII 1994-1996 and 1998 food intake surveys. The 1994-96, 98 data are based on the reported consumption of more than 20,000 individuals over two non-consecu tive survey days. Foods “as consumed” (e.g., apple pie)

Page 4 of 14Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 PC Code: 118602

______________________________________________________________________________________ 

### are linked to EPA-defined food commodities (e. g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by US DA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire US population and within population subgroups. Based on analysis of the 1994-96, 98 CSFII consumption data, which took into account dietary patterns of su rvey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups : the general U.S. population, all infants (<1 year old), child ren 1-2, children 3-5, children 6-12, youth 13- 19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessments, an estimate of the residue level in each food or food-form (e.g., orange or orange juice) on th e food commodity residue list is multiplied by the average daily consumption estimate fo r that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total av erage estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cRfD . This procedure is performed for each population subgroup.

For acute exposure assessments, individual one -day food consumption data are used on an individual-by-individual basis. The reported consumption amounts of each food item can be multiplied by a residue point estimate a nd summed to obtain a total daily pesticide exposure for a deterministic exposure asse ssment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of expos ures is expressed as a perc entage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a percapita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for all tiers of analysis.

V. Toxicological Information

All information specific to the toxicity char acteristics of imazosulf uron are presented in the most recent risk assessment supporting th e turf grass and orna mental uses (D348001, Sheila Healy et. al. , 13-MARCH-2009). For the acute and chronic exposure scenarios, the standard 100 fold UF was applied to accoun t for inter-species extrapolation and intraspecies variation. The FQPA Safety Factor be reduced to 1X because there is an adequate toxicity database for imazosulfur on; there is no evidence of susceptibility following in utero and/or postnatal exposur e in the developmental t oxicity studies in rats or rabbits, or in the 2-generation rat reproduction study and there are no residual uncertainties concerning pre- and postnatal toxicity and no neurotoxicity concerns. As previously noted, a cancer risk evaluation is not included in this assessment. To provide an overview of the toxicological profile, a su mmary of the doses and endpoints selected for the relevant dietary exposure scen arios is provided in Table 3.

Page 5 of 14Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 PC Code: 118602

______________________________________________________________________________________ Table 3. Summary of Toxicological Doses and Endpoints for Imazosulfuron for Use in Dietary Exposure Risk Assessments Exposure/ Scenario Point of Departure Uncertainty/FQPA Safety Factors RfD, PAD, Level of Concern Study and Toxicological Effects
Acute Dietary (All Populations) NOAEL = 400 mg/kg/day UF A = 10x
UF H = 10x FQPA SF = 1x aRfD = 4 mg/kg/day

aPAD = 4 mg/kg/day Acute neurotoxicity screening battery (MRID 47305319). LOAEL = 2000 mg/kg/day based on based on the following clinical signs: abnormal gait, decreased activity, piloerection and upward curvature of the spine; and incidents of irregular breathing, reduced righting reflex, tremors, decreased visual placement response in males and increased response to sound in one female. Chronic Dietary (All Populations) NOAEL =
75 mg/kg/day UF A = 10x UF H = 10x FQPA SF= 1x cRfD = 0.75 mg/kg/day

cPAD = 0.75 mg/kg/day Chronic toxicity (dog; MRID 47305305) LOAEL = 150 mg/kg/day based on based on increased relative liver weights, increased serum alkaline phosphatase activity and moderate thyroid hypertrophy (males only at mid-dose
Cancer Classification: “ Not likely to be Carcinogenic to Humans ” based on the absence of significant tumo r increases in two adequate rodent carcinogenicity studies (MRID 47305307, mouse; 47305306, rat). Point of Departure (POD) = A data point or an estimated point that is derived from obs erved dose-response data and used to mark the beginning of extrapolation to determine risk associated with lower e nvironmentally re levant human exposures. NOAEL = no observed adverse e ffect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (intraspecies). UF H = potential variation in sensitivity among members of the human population (i nterspecies). FQPA SF = FQPA Safe ty Factor. PAD = population-adjusted dose (a = acute, c = chronic). RfD = reference dose.



### VI. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table 4 are for the general US Population, all infant s (<1 year old), child ren 1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adu lts 20-49, and adults 50+ years.

Results of Acute and Chronic Dietary (F ood and Drinking Water) Exposure Analysis

Acute dietary risk analyses were conducte d with the DEEM-FCIDTM model to form a conservative evaluation of exposur e for imazosulfuron. At the 95 th 

### percentile of exposure, all acute analyses yielded risk estimates well below the 100% of the aPAD threshold level of concern for each populat ion subgroup. For food and drinking water, the U.S. Population subgroup acute aggregate dietary risk was calcu lated at <1% of the aPAD with an exposure level of 0.015 mg/kg/ day. For the subgroup with the highest calculated exposure, all infant s, acute aggregate dietary ri sk occupied 1.4% of the aPAD

Page 6 of 14Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 PC Code: 118602

______________________________________________________________________________________ 

### with an exposure of 0.06 mg/kg/day. Fo r the U.S. Population subgroup, acute dietary risk for food only was calculated at <1% of the aPAD with an exposure level of 0.00033 mg/kg/day. For the subgroup with the highe st calculated exposure, Children 1-2 years old, acute food only dietary risk occupied 0.02% of the aPAD with an exposure of 0.00090 mg/kg/day. An overview summarizing the results of the acute dietary assessments with the population subgroup ha ving the highest exposur e noted in bold is presented in Table 4.

Chronic dietary risk analyses were conducte d with the DEEM-FCIDTM model to form a conservative evaluation of exposure for imazosu lfuron. All chronic analyses yielded risk estimates well below the 100% of the cP AD threshold level of concern for each population subgroup. For food and drinking wate r, the U.S. Population subgroup chronic aggregate dietary risk was cal culated at <1% of the cPAD w ith an exposure level of 0.0060 mg/kg/day. For the subgroup with the hi ghest calculated expos ure, all infants, chronic aggregate dietary risk occupied 2.7% of the cPAD with an exposure of 0.020 mg/kg/day. For the U.S. Populati on subgroup, chronic dietary risk for food only was calculated at <1% of the cPAD w ith an exposure level of 0.000084 mg/kg/day. For the subgroup with the highest calculated exposure, all infants, chronic food only dietary risk occupied <1% of the cPAD with an exposure of 0.00020 mg/kg/day. An overview summarizing the results of the chronic di etary assessment with the population subgroup having the highest exposure noted in bold is presented in Table 4.

Table 4. Result of Acute and Chronic Dietary Exposure and Risk Estimates for Imazosulfuron. DEEM-FCID (food only) DEEM-FCID (food and water) Population Subgroup PAD, mg/kg/day Exposure, mg/kg/day % PAD* Exposure, mg/kg/day %PAD*

Acute Dietary Estimates (95 th Percentile of Exposure) U.S. Population 0.000333 <1 0.014919 <1
All infants (< 1 yr) 0.000367 <1 0.056034 1.4
Children 1-2 yrs 0.000896 <1 0.023470 <1 Children 3-5 yrs 0.000739 <1 0.021335 <1 Children 6-12 yrs 0.000494 <1 0.014925 <1 Youth 13-19 yrs 0.000313 <1 0.012125 <1 Adults 20-49 yrs 0.000277 <1 0.013800 <1 Adults 50+ yrs 0.000236 <1 0.012433 <1 Females 13-49 yrs 4.0

0.000259 <1 0.013772 <1
Chronic Dietary Estimates U.S. Population 0.000084 <0.01 0.006043 <1
All infants (< 1 yr) 0.000069 <0.01 0.019881 2.7
Children 1-2 yrs 0.000200 <0.01 0.009043 1.2 Children 3-5 yrs 0.000178 <0.01 0.008433 1.1 Children 6-12 yrs 0.000121 <0.01 0.005811 <1 Youth 13-19 yrs 0.000085 <0.01 0.004372 <1 Adults 20-49 yrs 0.75

0.000074 <0.01 0.005638 <1

Page 7 of 14Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 PC Code: 118602

______________________________________________________________________________________

Page 8 of 14 Table 4. Result of Acute and Chronic Dietary Exposure and Risk Estimates for Imazosulfuron. DEEM-FCID (food only) DEEM-FCID (food and water) Population Subgroup PAD, mg/kg/day Exposure, mg/kg/day % PAD* Exposure, mg/kg/day %PAD*

Adults 50+ yrs 0.000056 <0.01 0.005918 <1 Females 13-49 yrs 0.000069 <0.01 0.005605 <1 * % PADs are reported to 2 significant figures. The va lues for the highest popula tion for each type of risk assessment are bolded.



### VII. Characterization of Inputs/Outputs

The acute and chronic dietary assess ments conducted with DEEM-FCIDTM for imazosulfuron is an unrefined analysis. In addition to tolerance level residues, default processing factors, and 100% crop treated assumptions, it utilized conservative EDWCs derived through EFED modeling which are unlikely to underestimate the concentration of imazosulfuron in drinking water. The presen t DEEM-FCIDTM analysis assumes that all drinking water will contain imazosulfuron at the highest acute EDWC levels modeled by EFED for groundwater or surface water. For these reasons, it can be concluded that the DEEM-FCIDTM analysis does not underestimate risk from acute and chronic exposure to imazosulfuron for the general U.S. population and a ll its subgroups.

VIII. Conclusions

The conservative acute and chonic dietar y risk assessment conducted with DEEMFCIDTM indicates that exposures to imazosulf uron are below HED’s level of concern. The acute dietary risk to imazosulfuron is estimated to be <1.0% of the aPAD for the general U.S. population and 1.4% of the aP AD for the most highly exposed population subgroup, all infants (<1year old). The chronic dietary risk to imazosulfuron is estimated to be <1.0% of the cPAD for the general U. S. population and 2.7% of the cPAD for the most highly exposed population subgroup, all infants (<1year ol d). Therefore, HED does not have any concerns for the proposed new tolerances of imazosulfuron.

IX. List of Attachments

1. Attachment 1: Acute Dietary E xposure (food + water) Input File. 2. Attachment 2: Acute Dietary E xposure (food + water) Results File. 3. Attachment 3: Acute Dietary Exposure (food only) Results File. 4. Attachment 4: Chronic Dietary Exposure (food + water) Input File. 5. Attachment 5: Chronic Dietary Ex posure (food + water) Results File. 6. Attachment 6: Chronic Dietary Exposure (food only) Results File.Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 PC Code: 118602

______________________________________________________________________________________

Page 9 of 14 ATTACHMENT 1

U.S. Environmental Protection Agency Ver. 2.02 DEEM-FCID Acute analysis for IMAZASULFURON Residue file name: C:\Documents and Settings\cwalls\My Documents\Cassi\HED\Imazasulfuron\imazasulfuron food and water.R98 Analysis Date 06-22-2010 Residue file dated: 06-22-2010/10:24:18/8 Reference dose (aRfD) = 4 mg/kg bw/day
Comment: food and water

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Food Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 08002700 8 Pepper, bell 0.040000 1.000 1.000 08002701 8 Pepper, bell-babyfood 0.040000 1.000 1.000 08002710 8 Pepper, bell, dried 0.040000 1.000 1.000 08002711 8 Pepper, bell, dried-babyfood 0.040000 1.000 1.000 08002720 8 Pepper, nonbell 0.040000 1.000 1.000 08002721 8 Pepper, nonbell-babyfood 0.040000 1.000 1.000 08002730 8 Pepper, nonbell, dried 0.040000 1.000 1.000 15003230 15 Rice, white 0.040000 1.000 1.000 15003231 15 Rice, white-babyfood 0.040000 1.000 1.000 15003240 15 Rice, brown 0.040000 1.000 1.000 15003241 15 Rice, brown-babyfood 0.040000 1.000 1.000 15003250 15 Rice, flour 0.040000 1.000 1.000 15003251 15 Rice, flour-babyfood 0.040000 1.000 1.000 15003260 15 Rice, bran 0.040000 1.000 1.000 15003261 15 Rice, bran-babyfood 0.040000 1.000 1.000 08003740 8 Tomatillo 0.040000 1.000 1.000
08003750 8 Tomato 0.040000 1.000 1.000 08003751 8 Tomato-babyfood 0.040000 1.000 1.000 08003760 8 Tomato, paste 0.040000 5.400 1.000 08003761 8 Tomato, paste-babyfood 0.040000 5.400 1.000 08003770 8 Tomato, puree 0.040000 3.300 1.000 08003771 8 Tomato, puree-babyfood 0.040000 3.300 1.000 08003780 8 Tomato, dried 0.040000 14.300 1.000 08003781 8 Tomato, dried-babyfood 0.040000 14.300 1.000 08003790 8 Tomato, juice 0.040000 1.500 1.000 86010000 O Water, direct, all sources 0.278900 1.000 1.000 86020000 O Water, indirect, all sources 0.278900 1.000 1.000Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 PC Code: 118602

______________________________________________________________________________________

Page 10 of 14 **ATTACHMENT 2**

U.S. Environmental Protection Agency Ver. 2.02 DEEM-FCID ACUTE Analysis for IMAZASULFURON (1994-98 data) Residue file: imazasulfuron food and water.R98 Adjustment factor #2 NOT used. Analysis Date: 06-22-2010/10:01:25 Residue file dated: 06-22-2010/09:49:28/8 Daily totals for food and foodform consumption used.
Run Comment: "food and water"

===============================================================================

Summary calculations (per capita):

95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- U.S. Population:
0.014919 0.37 0.027950 0.70 0.056118 1.40 All infants:
0.056034 1.40 0.080087 2.00 0.144512 3.61 Children 1-2 yrs:
0.023470 0.59 0.039257 0.98 0.056476 1.41 Children 3-5 yrs:
0.021335 0.53 0.033273 0.83 0.053949 1.35 Children 6-12 yrs:
0.014925 0.37 0.024651 0.62 0.033323 0.83 Youth 13-19 yrs:
0.012125 0.30 0.019935 0.50 0.035854 0.90 Adults 20-49 yrs:
0.013800 0.34 0.022787 0.57 0.041542 1.04 Adults 50+ yrs:
0.012433 0.31 0.017753 0.44 0.028536 0.71 Females 13-49 yrs:
0.013772 0.34 0.022480 0.56 0.038811 0.97Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 PC Code: 118602

______________________________________________________________________________________

Page 11 of 14 **ATTACHMENT 3**

U.S. Environmental Protection Agency Ver. 2.02 DEEM-FCID ACUTE Analysis for IMAZASULFURON (1994-98 data) Residue file: imazasulfuron food.R98 Adjustment factor #2 NOT used. Analysis Date: 06-22-2010/09:56:16 Residue file dated: 06-22-2010/09:50:17/8 Daily totals for food and foodform consumption used. Run Comment: "food only"

===============================================================================

Summary calculations (per capita):

95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- U.S. Population:
0.000333 0.01 0.000711 0.02 0.001584 0.04 All infants:
0.000367 0.01 0.000930 0.02 0.001578 0.04 Children 1-2 yrs:
0.000896 0.02 0.001626 0.04 0.003325 0.08 Children 3-5 yrs:
0.000739 0.02 0.001372 0.03 0.002636 0.07 Children 6-12 yrs:
0.000494 0.01 0.000928 0.02 0.001723 0.04 Youth 13-19 yrs:
0.000313 0.01 0.000624 0.02 0.001317 0.03 Adults 20-49 yrs:
0.000277 0.01 0.000544 0.01 0.001020 0.03 Adults 50+ yrs:
0.000236 0.01 0.000461 0.01 0.000793 0.02 Females 13-49 yrs:
0.000259 0.01 0.000502 0.01 0.001030 0.03Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 PC Code: 118602

______________________________________________________________________________________

Page 12 of 14 ATTACHMENT 4

U.S. Environmental Protection Agency Ver. 2.00 DEEM-FCID Chronic analysis for IMAZASULFURON 1994-98 data Residue file: C:\Documents and Settings\cwalls\My Documents\Cassi\HED\Imazasulfuron\imazasulfuron food and water.R98 Adjust. #2 NOT used Analysis Date 06-22-2010 Residue file dated: 06-22-2010/10:24:18/8 Reference dose (RfD) = 0.75 mg/kg bw/day
Comment:food and water

-------------------------------------------------------------------------------- Food Crop Residue Adj.Factors

Comment EPA Code Grp Food Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ --

----- 08002700 8 Pepper, bell 0.040000 1.000 1.000 08002701 8 Pepper, bell-babyfood 0.040000 1.000 1.000 08002710 8 Pepper, bell, dried 0.040000 1.000 1.000 08002711 8 Pepper, bell, dried-babyfood 0.040000 1.000 1.000 08002720 8 Pepper, nonbell 0.040000 1.000 1.000 08002721 8 Pepper, nonbell-babyfood 0.040000 1.000 1.000 08002730 8 Pepper, nonbell, dried 0.040000 1.000 1.000 15003230 15 Rice, white 0.040000 1.000 1.000 15003231 15 Rice, white-babyfood 0.040000 1.000 1.000 15003240 15 Rice, brown 0.040000 1.000 1.000 15003241 15 Rice, brown-babyfood 0.040000 1.000 1.000 15003250 15 Rice, flour 0.040000 1.000 1.000 15003251 15 Rice, flour-babyfood 0.040000 1.000 1.000 15003260 15 Rice, bran 0.040000 1.000 1.000 15003261 15 Rice, bran-babyfood 0.040000 1.000 1.000 08003740 8 Tomatillo 0.040000 1.000 1.000
08003750 8 Tomato 0.040000 1.000 1.000 08003751 8 Tomato-babyfood 0.040000 1.000 1.000 08003760 8 Tomato, paste 0.040000 5.400 1.000 08003761 8 Tomato, paste-babyfood 0.040000 5.400 1.000 08003770 8 Tomato, puree 0.040000 3.300 1.000 08003771 8 Tomato, puree-babyfood 0.040000 3.300 1.000 08003780 8 Tomato, dried 0.040000 14.300 1.000 08003781 8 Tomato, dried-babyfood 0.040000 14.300 1.000 08003790 8 Tomato, juice 0.040000 1.500 1.000 86010000 O Water, direct, all sources 0.278900 1.000 1.000 86020000 O Water, indirect, all sources 0.278900 1.000 1.000Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 PC Code: 118602

______________________________________________________________________________________

Page 13 of 14 ATTACHMENT 5

U.S. Environmental Protection Agency Ver. 2.00 DEEM-FCID Chronic analysis for IMAZASULFURON (1994-98 data) Residue file name: C:\Documents and Settings\cwalls\My Documents\Cassi\HED\Imazasulfuron\imazasulfuron food and water.R98 Adjustment factor #2 NOT used. Analysis Date 06-22-2010/10:25:31 Residue file dated: 06-22-2010/10:24:18/8 Reference dose (RfD, Chronic) = .75 mg/kg bw/day
COMMENT 1: food and water

=============================================================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- --------------- U.S. Population (total) 0.005963 0.8%

U.S. Population (spring season) 0.005909 0.8% U.S. Population (summer season) 0.006399 0.9% U.S. Population (autumn season) 0.005766 0.8% U.S. Population (winter season) 0.005769 0.8%

Northeast region 0.005452 0.7% Midwest region 0.006025 0.8% Southern region 0.005666 0.8% Western region 0.006827 0.9%

Hispanics 0.006783 0.9% Non-hispanic whites 0.005814 0.8% Non-hispanic blacks 0.005661 0.8% Non-hisp/non-white/non-black 0.007330 1.0%

All infants (< 1 year) 0.019342 2.6% Nursing infants 0.007183 1.0% Non-nursing infants 0.023956 3.2% Children 1-6 yrs 0.008396 1.1% Children 7-12 yrs 0.005454 0.7%

Females 13-19 (not preg or nursing) 0.004218 0.6% Females 20+ (not preg or nursing) 0.005929 0.8% Females 13-50 yrs 0.005762 0.8% Females 13+ (preg/not nursing) 0.005796 0.8% Females 13+ (nursing) 0.008209 1.1%

Males 13-19 yrs 0.004414 0.6% Males 20+ yrs 0.005341 0.7% Seniors 55+ 0.005826 0.8%

Children 1-2 yrs 0.008929 1.2% Children 3-5 yrs 0.008351 1.1% Children 6-12 yrs 0.005758 0.8% Youth 13-19 yrs 0.004335 0.6% Adults 20-49 yrs 0.005562 0.7% Adults 50+ yrs 0.005831 0.8% Females 13-49 yrs 0.005534 0.7%

-------------------------------------------------------------------------------Imazosulfuron Dietary Exposure and Risk Assessment DP Number: 367020 PC Code: 118602

______________________________________________________________________________________

Page 14 of 14 ATTACHMENT 6

U.S. Environmental Protection Agency Ver. 2.00 DEEM-FCID Chronic analysis for IMAZASULFURON (1994-98 data) Residue file name: C:\Documents and Settings\cwalls\My Documents\Cassi\HED\Imazasulfuron\imazasulfuron food.R98 Adjustment factor #2 NOT used. Analysis Date 06-22-2010/09:51:32 Residue file dated: 06-22-2010/09:50:17/8 Reference dose (RfD, Chronic) = .75 mg/kg bw/day COMMENT 1: food only

=============================================================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- --------------- U.S. Population (total) 0.000084 0.0%

U.S. Population (spring season) 0.000082 0.0% U.S. Population (summer season) 0.000085 0.0% U.S. Population (autumn season) 0.000084 0.0% U.S. Population (winter season) 0.000086 0.0%

Northeast region 0.000089 0.0% Midwest region 0.000082 0.0% Southern region 0.000078 0.0% Western region 0.000092 0.0%

Hispanics 0.000110 0.0% Non-hispanic whites 0.000078 0.0% Non-hispanic blacks 0.000081 0.0% Non-hisp/non-white/non-black 0.000123 0.0%

All infants (< 1 year) 0.000069 0.0% Nursing infants 0.000035 0.0% Non-nursing infants 0.000082 0.0% Children 1-6 yrs 0.000183 0.0% Children 7-12 yrs 0.000114 0.0%

Females 13-19 (not preg or nursing) 0.000082 0.0% Females 20+ (not preg or nursing) 0.000061 0.0% Females 13-50 yrs 0.000075 0.0% Females 13+ (preg/not nursing) 0.000080 0.0% Females 13+ (nursing) 0.000064 0.0%

Males 13-19 yrs 0.000089 0.0% Males 20+ yrs 0.000074 0.0% Seniors 55+ 0.000055 0.0%

Children 1-2 yrs 0.000200 0.0% Children 3-5 yrs 0.000178 0.0% Children 6-12 yrs 0.000121 0.0% Youth 13-19 yrs 0.000085 0.0% Adults 20-49 yrs 0.000074 0.0% Adults 50+ yrs 0.000056 0.0% Females 13-49 yrs 0.000069 0.0%

-------------------------------------------------------------------------------