[Type text]

EPA REGISTRATION DIVISION COMPANY NOTICE OF FILING FOR 

PESTICIDE PETITIONS PUBLISHED IN THE FEDERAL REGISTER 

EPA Registration Division contact: [insert name and telephone number with area 

code]

INSTRUCTIONS: Please utilize this outline in preparing the pesticide petition. In 

cases where the outline element does not apply, please insert “NA-Remove” and 

maintain the outline. Please do not change the margins, font, or format in your 

pesticide petition. Simply replace the instructions that appear in green, i.e., “[insert 

company name],” with the information specific to your action.

TEMPLATE:

[ Bayer CropScience]

[Insert petition number]

EPA has received a pesticide petition from [Bayer CropScience], [2 T.W. 

Alexander Drive, Research Triangle Park, NC 27709] proposing, pursuant to section 

408(d) of the Federal Food, Drug, and Cosmetic Act (FFDCA), 21 U.S.C. 346a(d), to 

amend 40 CFR part 180 by:

1) establishing a tolerance for residues of [fluopyram (N-[2-[3-chloro-5-

(trifluoromethyl)-2-pyridinyl]ethyl]-2-(trifluoromethyl)benzamide)] in or on the raw 

agricultural commodities [artichoke, globe] at [4.0] ppm, [aspirated grain fractions] at

[50.0] ppm, [peanut hay] at [40.0] ppm, [hops] at [60.0] ppm, [root vegetables; except 

beet, sugar, root, crop subgroup 1B] at [0.30] ppm, [tuberous and corm vegetables, 

crop subgroup 1C] at [0.10] ppm, [potato wet peel] at [0.30] ppm, [vegetables, leaves 

of root and tuber, crop group 2] at [30.0] ppm, [bulb vegetables, bulb onion (crop 

subgroup) 3-07A] at [0.30] ppm, [bulb vegetables, green onions (crop subgroup 3-

07B] at [15.0] ppm [Leafy greens (crop subgroup 4A), without spinach] at [20.0] ppm, 

[Leafy greens (crop subgroup 4A), Spinach] at [40.0] ppm, [leafy petioles subgroup, 

celery (crop subgroup 4B)] at [20.0] ppm, [brassica leafy vegetables: head and stem 

(crop subgroup 5A)] at [4.0] ppm, [brassica leafy vegetables: leafy greens(crop 

subgroup 5B)] at [50.0] ppm, [soybean, seed] at [0.30] ppm, [soybean forage] at [9.0] 

ppm, [soybean hay] at [30.0] ppm, [legume vegetables: edible podded (crop subgroup 

6A)] at [4.0] ppm, [legume vegetables: succulent shelled peas and beans (crop 

subgroup 6B)] at [0.20] ppm, [legume vegetables: dried shelled peas and beans (crop 

subgroup 6C)] at [0.70] ppm, [Vegetable, foliage of legume vegetables, forage, hay 

and vines, forage (crop group 7)] at [90.0] ppm, [fruiting vegetables, tomato 

subgroup (crop subgroup 8-10A)] at [1.00] ppm, [fruiting vegetables, 
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pepper/eggplant subgroup (crop subgroup 8-10B)] at [3.00] ppm, [cucurbit

vegetables (crop group 9A), melon subgroup] at [0.90] ppm, [cucurbit vegetables 

(crop group 9B), cucumber/squash subgroup] at [0.30] ppm, [citrus fruits (crop 

group 10-10)] at [0.90] ppm, [citrus oil] at [8.0] ppm, [pome fruit (crop group 11-10)] 

at [2.0] ppm, [stone fruit (crop group 12-12A), cherry subgroup] at [2.00] ppm, [stone 

fruit (crop group 12-12B), peach Subgroup] at [1.00] ppm, [stone fruit (crop group 

12-12C), plum Subgroup] at [0.50] ppm, [berries and small fruit: caneberry (crop 

subgroup 13-07A] at [5.0] ppm, [berries and small fruit: bushberry (crop subgroup 

13-07B] at [7.0] ppm, [raisins] at [4.0] ppm, [berries and small fruit, small fruit vine 

climbing, except fuzzy kiwi (crop subgroup 13-07F)] at [1.5] ppm, [berries and small 

fruit: low growing berry (crop subgroup 13-07G)] at [2.0] ppm, [sorghum, grain] at

[1.5] ppm, [wheat milled by-products] at [2.0] ppm, [grass forage, fodder and hay: 

forage (crop group 17)] at [80.0] ppm, [herb crop (subcrop group 19A)] at [70.0] 

ppm, [Dill seed] at [70.00] ppm, [herbs, dried ] at [400] ppm, [oilseeds, rapeseed, 

canola (crop subgroup 20A)] at [0.70] ppm, [oilseeds, sunflower, seed (crop subgroup 

20B)] at [0.70] ppm, [oilseeds: cottonseed (crop subgroup 20C)] at [0.80] ppm,; and

and in or on animal commodities: [chicken, meat byproducts] at [0.40] ppm, [chicken, 

fat] at [0.15] ppm, [chicken, meat] at [0.10] ppm, , [goat, fat] at [4.00] ppm, [goat, 

meat] at [4.00] ppm; and

2) amending existing tolerances for residues of [fluopyram (N-[2-[3-chloro-5-

(trifluoromethyl)-2-pyridinyl]ethyl]-2-(trifluoromethyl)benzamide)] in or on the raw 

agricultural commodities [peanut] at [0.20] ppm, [sugar beet, roots] at [0.09] ppm, 

[soybean forage] at [9.0] ppm, [soybean hay] at [30.0] ppm, [tree nuts (crop group 

14)] at [0.04] ppm, [almond hulls] at [10.00] ppm, [Grain, Cereal , except rice and 

sorghum(crop group 15)] at [0.90] ppm, [cereal grain, except rice, forage, fodder and 

straw (crop group 16)] at [20.0] ppm, [cotton gin by-product] at [30.00] ppm; and in 

or on animal commodities: [cattle, meat byproducts] at [40.00] ppm, [cattle, fat] at

[4.00] ppm, [cattle, meat] at [4.00] ppm, [milk, cattle] at [2.00] ppm, [eggs, chicken] at

[0.20] ppm, [hog, meat byproducts] at [0.40] ppm, [hog, fat] at [0.04] ppm, , and [hog, 

meat] at [0.04] ppm, [horse, meat byproducts] at [40.00] ppm, [horse, fat] at [4.00] 

ppm, [horse, meat] at [4.00] ppm, [goat, meat byproducts] at [40.00] ppm, [sheep,

meat byproducts] at [40.00] ppm, [sheep, fat] at [4.00] ppm, [sheep, meat] at [4.00] 

ppm; and

3) deleting existing single tolerances for residues of [fluopyram (N-[2-[3-chloro-5-

(trifluoromethyl)-2-pyridinyl]ethyl]-2-(trifluoromethyl)benzamide)] in or on the raw 

agricultural commodities [apple] at [0.30] ppm, [bean, dry] at [0.09] ppm, [beet, sugar , 

roots] at [0.04] ppm, [apple wet pomace] at [0.60] ppm, [cherry] at [0.60] ppm, [grape, 

wine] at [2.0] ppm, [potato] at [0.02] ppm, [strawberry] at [1.5] ppm, [watermelon] at

[1.0] ppm; and

4) establishing tolerance for indirect or inadvertent residues of [fluopyram (N-[2-[3-

chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl]-2-(trifluoromethyl)benzamide)] in or 

on the raw agricultural commodities [sugarcane, cane ] at [0.08] ppm.
3

EPA has determined that the petition contains data or information regarding the elements 

set forth in section 408 (d)(2) of FDDCA; however, EPA has not fully evaluated the 

sufficiency of the submitted data at this time or whether the data supports granting of the 

petition. Additional data may be needed before EPA rules on the petition.

A. Residue Chemistry

1. Plant metabolism. [Plant metabolism studies with fluopyram were 

performed in grapes, potatoes, and beans after spray applications, on red bell 

pepper after drip irrigation and wheat after seed treatment. The metabolism in all 

cases was very similar. The main reactions involved were hydroxylation of the 

parent compound to AE C656948-7-hydroxy and AE C656948-8-hydroxy,

conjugation of the hydroxylated parent compound mainly with sugars, and cleavage 

of the molecule leading to AE C656948-benzamide, AE C656948-pyridyl-acetic acid 

(PAA) and AE C656948-carboxylic acid (PCA).]

2. Analytical method. [Fluopyram is the residue of concern in plant 

commodities required for analysis based on the metabolic profile, except for 

legumes and oilseeds where AE C656948-benzamide is also included for risk 

assessment purposes. Fluopyram and AE C656948-benzamide are the residues of 

concern in milk, eggs and animal tissues. The analytical methods for crops and 

animal matrices are similar and involve solvent extraction, filtration and addition of 

an isotopically labeled internal standard followed by solid phase extraction. 

Quantitation is by high performance liquid chromatography-electrospray 

ionization/tandem mass spectrometry (LC/MS/MS).]

3. Magnitude of residues. [Magnitude of residue trials were conducted in the 

various required regions across the United States and Canada in accordance with 

EPA guidance for crop field trials under OPPTS 860.1500 to support the requested 

tolerances. Magnitude of the residue trials were conducted in greenhouses in

Europe to support uses in selected crops.]

B. Toxicological Profile

1. Acute toxicity. [Fluopyram has low acute toxicity to mammals irrespective 

of the route of exposure (oral, percutaneous or inhalation exposure). It is not a skin 

sensitizer, it is non-irritating to skin and causes only a minimal reversible redness of 

the conjunctivae in the rabbit eye. Overall it is classified as Toxicity Classification 

III. In an acute neurotoxicity study and a follow-up study a NOAEL of 125 mg/kg 

and 50 mg/kg was established for males and females, respectively based on slight 

decreases in measures of motor and locomotor activity, clinical signs and decreased 

body temperature.]

2. Genotoxicty. [Genotoxicity potential was evaluated in a series of tests 
4

including in vitro and in vivo tests. There was no indication of gene mutation either 

in the presence or absence of metabolic activation in both the bacterial reverse 

mutation and mammalian gene mutation tests. The in vitro chromosome aberration 

test and the in vivo mouse micronucleus test were also both negative. These studies 

demonstrated that fluopyram has no genotoxic potential.]

3. Reproductive and developmental toxicity. [In the rat two-generation 

reproduction study, the parental systemic NOAEL was 220 ppm (14.5 mg/kg/day in 

males, 17.2 mg/kg/day in females) based on clinical pathology changes, increased 

liver weight, protein droplet nephropathy (males) and centrilobular hypertrophy. 

The reproductive NOAEL was 1200 ppm in both males and females (82.8 mg/kg/day 

in males and 93.1 mg/kg/day females), based on no reproductive findings observed 

in the highest dose tested. The offspring NOAEL was 220 ppm (17.0 mg/kg/day) 

based on maternal effects leading to secondarily-mediated effects on pup weight and 

pup weight gain. Also noted was a slight delay in preputial separation and decrease 

in spleen and thymus weights for F2-pups (both findings considered secondary to 

pup weight decrease). In a rat developmental toxicity study, the maternal NOAEL 

was 30 mg/kg/day, based on a transient reduction on maternal body weight gain and 

food consumption. The fetal NOEL was 150 mg/kg/day based on decreased fetal

body weight and incidence of two minor variations at both the visceral and skeletal 

evaluation. In a rabbit developmental toxicity study the NOEL was 25 mg/kg/day 

both in the dam (reduced body weight gain and food consumption) and in terms of 

fetal development (decreased fetal body weight) in the New Zealand White rabbit.]

4. Subchronic toxicity. [Subchronic studies showed that the liver is the major 

target organ in rats, mice, and dogs. The effects observed were consistent with the 

induction of cytochrome P450. In addition to the liver, the thyroid and kidney 

(males) were also target organs in rats. In the male rat, specific nephropathy 

(hyaline droplet nephropathy) was observed. The thyroid gland effects were 

secondary to the liver toxicity. In mice adrenal glands, a lower incidence of ceroid 

pigment was noted in males, whilst a greater incidence of minimal to slight cortical 

vacuolation was observed in females. The most sensitive species is considered to be 

the rat. The dog appeared to be less sensitive than the rat but of similar sensitivity to 

the mouse. Overall, the lowest NOAEL was observed in the subchronic rat study. In 

this study the NOAEL for the rat was established at 3.6 and 14.6 mg/kg bw/day in 

males and females, respectively. However, the NOAEL in the male rats was based 

on the specific hyaline droplet nephropathy (and associated effects) observed at the 

dose level of 12.5 mg/kg/day which is known to be non-relevant for humans since 

this specific nephropathy is due to an accumulation of 2μ-globulin in the proximal 

tubules, a protein that is only found in trace amounts in humans. Therefore the

relevant NOAEL was considered to be 12.5 mg/kg/day since there was no other 

adverse effect at this dose level. This NOAEL is also comparable with the NOAEL 

in the 1-year dog study (13.2 mg/kg/day) and the parental and offspring NOAELs 

(14.5 and 17.0 mg/kg/day, respectively) in the reproduction study. 

In a 90-day neurotoxicity study at 0, 100, 500 and 2500 ppm, no evidence of 
5

neurotoxicity was observed at any treatment level. Treatment-related findings of 

general toxicity at the high dose consisted of decreased body weight, total body 

weight gain and food consumption in males and females, increased cholesterol and 

triglyceride levels in males and/or females and decreased terminal body weight in 

females. Also, liver and kidney weights (absolute and relative) were increased in 

high-dose males and liver weight (absolute and relative) was increased in high-dose 

females. The only finding at the mid-dose was decreased food consumption in 

females, which was not associated with any effect on body weight. Based on 

neurotoxicology endpoints, a NOAEL of 2500 ppm was established for males and 

females (164.2 and 197.1 mg/kg for male and female rats, respectively).

In a four week dermal toxicity study in rats, a NOAEL of 300 mg/kg/day was 

established based on an increased cholesterol concentration in females, an increased 

prothrombin time in males and effects on the liver (increased liver weights for males 

and females associated with hepatic hypertrophy). The increased liver weights and 

hypertrophy in the high dose group were attributed to hepatic enzyme induction 

and thus were considered to be an adaptive response to fluopyram.]

5. Chronic toxicity. [In the rat combined chronic toxicity and carcinogenicity 

study eye lesions were observed in high dose females. There was marked treatmentrelated liver toxicity together with nephropathy in the kidney and follicular cell 

hypertrophy in the thyroid gland. Liver cell tumors (carcinoma and adenoma) were 

observed in high dose females. Additional data support an indirect, non-genotoxic, 

phenobarbital-like mechanism of action regarding the liver cell tumor formation 

observed in the female rat. The mode of action for phenobarbital-like inducers is 

considered to be of limited relevance to humans.

In a mouse carcinogenicity study, the target organs were the liver, kidney and 

thyroid gland. Nephropathy was observed in the kidney in high dose females. The 

principal change noted in the liver was centrilobular to panlobular hypertrophy, 

which was seen in both sexes, and hepatocellular single cell degeneration /necrosis in 

males. Treatment-related follicular cell hyperplasia was observed in both sexes. 

Thyroid gland follicular cell adenomas were observed in high dose males. 

Additional mechanistic data support the hypothesis of a non-genotoxic indirect 

threshold mechanism (likely to be secondary to the liver effect) for the formation of 

thyroid follicular cell adenomas in male mice for which a clear NOAEL was 

established at 30 ppm (1.20 and 1.68 mg/kg/day in males and females, respectively)

in the oncogenicity study. Furthermore, the relevance of this mechanism to humans 

is considered as limited since it is well recognized and accepted that humans are 

considerably less sensitive than rodents to elevated TSH level or alteration of the 

thyroid function and to thyroid follicular cell tumors.]

6. Animal metabolism. [Available metabolism studies have established that 

fluopyram is rapidly and almost completely absorbed (>93% of the dose in bile 

fistulation experiments) by rats following oral administration by gavage. Fluopyram 

was extensively metabolized with unchanged parent compound found only in low 

percentages of the recovered dose. The metabolism of fluopyram in male and female 
6

rats was principally oxidative and took place mainly at the ethylene bridge of the 

molecule. Some cleavage of the rings was observed as was conjugation of several 

hydroxylated metabolites with glucuronic acid and to a lesser extent with sulfate. 

The metabolic transformation of the parent compound was generally more 

pronounced in male rats.]

7. Metabolite toxicology. [Not applicable as parent is the compound of 

concern.]

8. Endocrine disruption. [There is no evidence to suggest that fluopyram has 

any primary endocrine disruptive potential. Reproductive and developmental 

findings provided no evidence of an enhanced sensitivity of the young. Bayer 

CropScience will conduct any studies that may be required under EPA’s Endocrine 

Disrupter Screening Program.]

C. Aggregate Exposure

1. Dietary exposure. [The toxicological and exposure database for fluopyram

is considered complete. There was no indication of an increased sensitivity of the 

young in any studies including the reproductive and developmental studies in rats 

and rabbits. Therefore, the special FQPA safety factor can be reduced to 1X and an

uncertainty factor of 100 is adequate to account for inter- and intra- species 

variability. Acute and chronic Population Adjusted Doses (aPAD and cPAD) are, 

therefore, the same as the reference doses for the populations and subpopulations of 

interest. Acute dietary exposure was expressed as a percentage of the aPAD of 0.5 

mg/kg bw/day from a NOAEL of 50 mg/kg bw/day established for females, based on 

slight decreases in measures of motor and locomotor activity in the acute 

neurotoxicity study, with an uncertainty factor of 100. Chronic dietary exposure 

was expressed as a percentage of the chronic Population Adjusted Dose (cPAD) of 

0.012 mg/kg bw/day based on a NOAEL of 1.2 mg/kg bw/day in the rat 

chronic/carcinogenicity study with an uncertainty factor of 100. Mechanistic studies 

support the hypothesis that the mouse thyroid and rat liver tumors seen in the 

chronic studies are from a non-genotoxic indirect threshold mechanism and are not 

relevant to humans. A cancer (q1*) dietary risk assessment is not required.

i. Food. [Tier 3 acute and chronic dietary risk assessments were conducted to 

evaluate the dietary exposure of the U.S. population and selected subpopulations to 

fluopyram residues. This assessment includes all proposed crops and secondary 

residues in tissues and milk. Projected Percent Crop Treated (PPCT) were generally 

based on the market leader method guidance developed by BEAD/EPA.

Adjustments were made to the crop residue values to represent the effects of 

commercial and domestic preparation and processing. The Tier 3 acute and chronic 

assessments were conducted using DEEM-FCID Ver.3.16 software. Consumption 

data used in this program were taken from NHANES WWEIA 2003-2008. Acute 

exposure (99.9th percentile) for food only utilizes 24% of the aPAD for the US 

Population and 42% for Children 1-2, the most highly exposed subpopulation. 

Chronic exposure utilizes 18% of the cPAD for the US Population and 61% of the 

cPAD for Children 1-2, the most highly exposed subpopulation.]
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ii. Drinking water. [Estimated Drinking Water Concentrations (EDWCs) 

associated with fluopyram use on all crops were calculated using PRZM-GW (ver 

1.07) and FIRST (FQPA Index Reservoir Screening Tool: Version 1.1.1, March 25, 

2008) to calculate ground water and surface water EDWCs, respectively. EDWCs 

were calculated for fluopyram parent, which is considered the residue of concern 

based on laboratory and field studies which showed limited degradation products. 

The maximum acute and chronic ground water concentrations estimated by PRZMGW were 69.5 ppb and 65 ppb, respectively, and were higher than the surface water 

estimates.The value from the highest PRZM-GW exposure scenarios were 

incorporated into the dietary risk assessment. The addition of the acute estimated 

drinking water concentration (EDWC) of 69.5 ppb resulted in 25% of the aPAD 

utilized for the US Population and 43% utilized for Children 1-2, the most highly 

exposed subpopulation. The addition of the chronic EDWC of 65 ppb utilized 29% 

of the cPAD for the US Population and 77% of the cPAD for Children 1-2, the most 

highly exposed subpopulation. In conclusion, the results of the acute and chronic 

Tier 3 dietary exposure analyses (including drinking water) are acceptable for all 

population subgroups examined. Therefore, there is a reasonable certainty that no 

harm will result from exposure to potential residues of fluopyram in food and 

water.]

2. Non-dietary exposure. [There is a potential for exposure from non-dietary 

turf and ornamental proposed uses. Fluopyram may be applied using foliar spray 

or chemigation to turf in golf courses, sport fields, residential, institutional, 

municipal, and commercial areas as well as field grown and container ornamentals 

(Christmas trees, ornamental sunflowers, and non-bearing cherries, pome fruit 

trees, tree-nuts, grapes, stone fruit trees, and citrus) in landscapes, nurseries, and 

greenhouses, lathhouses, shadehouses, interiorscapes and other enclosed structures. 

All products are intended for professional use however, the possibility that a 

homeowner could obtain and apply these products. Therefore, a potential for 

residential handler short-term exposure exists. There is also a potential for shortterm post-application exposure for golfers as well as adults and toddlers in 

residential settings. An MOE of 100 is adequate to ensure protection of these 

populations from fluopyram via the dermal exposures. For toddlers, an MOE of 

100 is adequate to ensure protection via incidental oral exposures (hand-to-mouth, 

object-to-mouth, soil ingestion). For all populations, exposure estimates were 

assessed based on the day of treatment. All of the calculated MOEs were greater 

than 900 which is above the level of concern.

D. Cumulative Effects

[Section 408(b)(2)(D)(v) requires that, when considering whether to establish, 

modify, or revoke a tolerance, the Agency consider “available information” 

concerning the cumulative effects of a particular pesticide’s residues and “other 

substances that have a common mechanism of toxicity.” Fluopyram is a novel 

fungicide of the chemical class of pyridylethylamides. EPA has not made a common 
8

mechanism of toxicity finding as to fluopyram and any other substances and 

fluopyram does not appear to produce a toxic metabolite produced by other 

substances.]

E. Safety Determination

1. U.S. population. [Risk assessments for fluopyram are based on a complete 

and reliable toxicity data package and highly conservative assumptions. Chronic 

aggregate dietary exposure (food and water) will utilize less than 29% of the cPAD 

for the US Population. Acute aggregate dietary exposure (food and water) for the 

U.S. population, utilizes 25% of the aPAD. Non-dietary and aggregate MOEs 

(food, drinking water, and non-dietary) are above the Level of Concern. Therefore, 

there is a reasonable certainty that no harm will occur to the US Population from 

aggregate exposure (food, drinking water and non-dietary) to residues of 

fluopyram.]

2. Infants and children. [The toxicological and exposure database for 

fluopyram is considered complete. There was no indication of an increased 

sensitivity of the young in any studies including the reproductive and developmental 

studies in rats and rabbits. Therefore, the special FQPA safety factor can be 

reduced to 1X and an uncertainty factor of 100 is adequate. Chronic aggregate 

dietary exposure (food and water) utilizes 77% of the cPAD for Children 1-2, the 

most highly exposed subpopulation. Acute aggregate dietary exposure (food and 

water) utilizes 43% of the aPAD for Children 1-2, the most highly exposed 

subpopulation. The aggregate (food, drinking water, and incidental oral exposure) 

risk for Children 1-2 had a combined MOE = 108 which is above the level of 

concern (100). Therefore, there is a reasonable certainty that no harm will occur to 

infants and children from aggregate exposure (food, drinking water and nondietary) to residues of fluopyram.]

F. International Tolerances

[In the EU, tolerances for fluopyram were established for: barley, 

buckwheat, millet and oats (0.1 ppm); maize (0.02 ppm); rye and wheat (0.8 ppm) 

and sorghum (1.5 ppm); artichoke, globe (0.5 ppm); hops (0.01 ppm); sugar beet 

roots (0.1 ppm); potatoes, root vegetables and corm vegetables (0.1 ppm); bulb 

vegetables (2 ppm); leafy vegetables (1.5 ppm); brassicas (0.7 ppm); soybean (0.2 

ppm); legume, edible pod (0.9 ppm); fruiting vegetables (0.9 ppm); citrus (0.01 

ppm); apple (0.6 ppm); stone fruit (1.5 ppm); grapes (1.5 ppm); tree nut (0.05 ppm); 

rape seed (canola) (0.6 ppm); sunflower, seed (0.1 ppm); cottonseed (0.1 ppm); meat 

(0.1 ppm); milk (0.3 ppm) and eggs (0.3). In CODEX, tolerances for fluopyram 

were established for: sugar beet roots (0.04 ppm); potatoes, root vegetables and 

corm vegetables (0.03 ppm); bulb vegetables (1.5 ppm); leafy vegetables (1.5 ppm); 

brassicas (0.8 ppm); legume, dry bean (0.07 ppm); legume, chickpeas and dried 

lentils (0.07 ppm); apple (0.3 ppm); stone fruit (1.5 ppm); grapes (2.0 ppm); tree nut 

(0.04 ppm); rape seed (canola) (1.8 ppm); meat (0.5 ppm); milk (0.4 ppm) and eggs 
9

(0.3). In Canada, tolerances for fluopyram were established as follows: barley, 

buckwheat, millet and oats (1.5 ppm); maize (1.5 ppm); rye and wheat (1.5 ppm) 

and sorghum (1.5 ppm); artichoke, globe (0.02 ppm); sugar beet roots (0.1 ppm); 

potatoes, root vegetables and corm vegetables (0.02 ppm); soybean (0.01 ppm); 

legume, dry bean (0.09 ppm); legume, chickpeas and dried lentils (0.4 ppm); apple 

(0.5 ppm); stone fruit (1.5 ppm); grapes (2.0 ppm); tree nut (0.05 ppm); cottonseed 

(0.01 ppm); meat (0.4 ppm); milk (0.06 ppm) and eggs (0.06). ]