### Federal Register / Vol. 56, No. 44 / Wednesday, March 6, 1991 / Notices

ENVIRONMENTAL PROTECTION
AGENCY [OPTS-41034; FRL 3845-3] Twenty-Seventh Report of the Interagency Testing Committee to the Administrator, Receipt of Report and Request for Comments Regarding Priority Listof Chemicals
AGENCY: Environmental Protection Agency (EPA). ACTION: Notice.
SUMMARY: The Interagency Testing Committee (ITC), established under section 4[e) of the Toxic Substances Control Act (TSCA), transmitted its Twenty-seventh Report to the Administrator ofEPAon November 19, 1990. As noted inthis Report, which is included with this notice, the Committee revised the Priority List by adding one chemical and four chemical groups. The Committee is designating six chemicals from the IRIS group, as well as 4- vinylcyclohexene and sodium cyanide, that were previously recommended with intent-to-designate. The aldehydes chemical group is recommended with intent-to-designate. N-phenyl-1- naphthylamine, two chemicals from the IRIS group, the sulfone group, and a group of substantially produced chemicals in need of subchronic tests
are recommended.

The ITC has not removed any chemicals from the Priority List as a result ofEPA actions.

EPA invites interested persons to submit written comments on the Report. EPA is not holding a Focus Meeting for these chemicals and will proceed immediately to rulemaking. EPA is taking this action because (1) The designated chemicals have a statutory deadline and require a response by EPA within I year: and (2) the intent-todesignate group is unlikely to yield

consensus in a timely manner because of the inability to identify interested parties on a chemical specific basis. DATES: Written comments should be submitted by April 5, 1991. ADDRESSES- Send written submissions bearing the document control number (OPTS-41034; FRL 3845-3) to: TSCA Public Docket Office (TS-793), Office of Toxic Substances, Environmental Protection Agency, Rm. NE G--004, 401 M St., SW., Washington, DC 20460.

The public record supporting this action, including comments, is available for public inspection in Rm. NE G-004 at the address noted above from 8 a.m. to 12 noon and 1 p.m. to 4 p.m., Monday through Friday, except legal holidays. FOR FURTHER INFORMATION CONTACT. Michael M. Stahl, Director, Environmental Assistance Division (TS799), Office ofToxic Substances, Environmental Protection Agency, Rm. E-543B,401 M St., SW.,Washington, DC 20460, (202) 554-1404, TDD (202] 554- 0551.
SUPPLEMENTARY INFORMATION: 

### EPAhas received the TSCA Interagency Testing Committee's Twenty-seventh Report to the Administrator.
I. Background

TSCA (Pub. L 94-469, 90 Stat.2003 et seq; 15 U.S.C. 2601 etseq.) authorizes the Administratoi ofEPA to promulgate regulations under section 4(a) requiring testing of chemicals and groups in order to develop data relevant to determining the risks that such chemicals and groups may present tohealth or the environment. Section 4(e) ofTSCA established the Interagency Testing Committee torecommend chemicals and groups to the Administrator ofEPA for priority testing consideration. Section 4(e) directs the ITCto revise the TSCA section 4(e) Priority List at least every 6 months. The ITC's most recent revisions to this List are included in the Committee's Twenty-seventh Report. The Report was received by the Administrator on November 19, 1990, and is included in this Notice. The Report adds one chemical and four groups ofchemicals to the TSCA section 4(e) Priority List.
I. Written and Oral Comments and Public Meetings

EPA invites interested persons to submit detailed comments on the ITC's

new recommendations. The Agency is interested in receiving information concerning additional or ongoing health and safety studies on the subject chemicals as well as information relating to the human and environmental exposure to these chemicals.

A notice will be published at alater date in the Federal Register adding most ofthe substances recommended in the ITC's Twenty-seventh Report to the TSCA section 8(d) Health and Safety Data Reporting Rule (40 CFR part 716), which requires the reporting of unpublished health and safety studies

on the listed chemicals. The delay in publishing that notice is necessary because ofthe requirement to complete the economic analysis on four chemical groups. That notice will also add most of the chemicals to the TSCA section 8[a) Preliminary Assessment Information Rule (40 CFR part 712). The section 8(a) rule requires the reporting ofproduction volume, use, exposure, and release information on the listed chemicals. 11. Status ofList 

### The ITC's Twenty-seventh Report notes the addition ofchemicals and chemical groups to the Priority List. The current List contains two designated chemicals, two designated chemical groups, three recommended with intentto-designate chemical groups, four recommended chemicals, and five recommended chemical groups.

Authority: 15 U.S.C. 2603. 

### Dated: February 26, 1991. Charles M.Auer, Director, ExistingChemical Assessment Division,OfficeofToxic Substances. 

### Twenty-Seventh Report of the Interagency Testing Committee to the Administrator, Environmental Protection Agency Summary

The U.S. Congress created the Interagency Testing Committee in 1976 to screen, select and recommend chemical substances and mixtures for priority health effects, chemical fate, or ecological effects testing consideration. The Committee (which consists of Members from 18 U.S. Government organizations) selects and recommends chemicals or chemical groups with testing information deficiencies because they may present an unreasonable risk ofinjury to health or the environment, may reasonably be anticipated to enter the environment in substantial quantities ormay involve significant or substantial human exposure.

The Committee also facilitates coordination ofchemical testing sponsored or required by U.S. Government organizations and enhances information exchange to promote cost-effective use ofU.S. Government chemical testing resources. The Committee's statutory responsibilities are defined in section 4(e) ofthe Toxic Substances Control Act (TSCA) (Pub. L.94-469, 90 Stat. 2003 et seq., 15 U.S.C. 2601 etseq.).

Section 4(e)(1)(A) ofTSCA directs the Committee torecommend to the Administrator ofthe U.S. Environmental Protection Agency (EPA), chemicals or chemical groups to which the Administrator should give priority testing consideration. Under the authority ofTSCA section 4(e)(1)(B) the EPAAdministrator shall publish in the Federal Register the Committee's Priority List ofchemicals orchemical groups and their associated testing recommendations. The Committee is required to designate those chemicals, from among its recommendations, to which the Administrator should respond 9534

### Federal Register / VoL 56, No. 44 / Wednesday, March 6, 1991 / Notices

within 12 months by either initiating rulemaking under TSCA section 4(a) or publishing the reasom fornot initiating rulemaking. The Congress directed the Committee torevise the TSCA section 4[e) PriorityList at least every 6 months, and to transmit those revisions to the EPA Administrator.

As aresult ofits deliberations, the Committee is revising the TSCA section 4(e) Priority List by designating two chemicals that were previously recommended with intent-to-designate and by adding one chemical and four chemical groups. The addedchemical
was nominated by the Occupational Safety andHealth Administration. Two chemical groups were nominated by the EPA. TheCommittee's computerized. substructure-based chemical selection processes were used to identify the chemicals in the aldehyde group nominated by EPA as well as the chemicals in two chemical groups that either shared a common substructure or acommon testing information deficiency. During this reporting period, the Committee considered available information on three chemicals and over thirtychemical groups. The Committee also deferred about 700 hundred chemicals from testing consideration at this time.

Chemicals or chemical groups (entries) on the Priority List are designated, recommended with intentto-designate orrecommended by the Committee. Designations were created by the U.S. Congress when they drafted TSCA. Recommendations with intent-todesignate were established by the Committee in their 17th Report (50 

### FR 47603; November 19, 1985). 

### Recommendations were established by the Committee in their lth Report (47 

### FR 54626; December 3,1982). Revisions to the Priority List arepresented, together with the types oftesting recommended, in Table 1.The footnote letters following Table I 

### acknowledge the Committee's efforts to coordinate chemical testing and to comprehensively examine ongoing testing-related activities and available information previously submitted under TSCA.

TABLE 1.-REVISIONS TO THE SECTION 4(E) PRIORITY LIST

Gre CAS No. Chemical Action Date Recommended tests

IRIS

......................................

IRIS

. . . ..................

IRIS

. ..................... .......

IRIS

..................................

IRIS

.............. ................

Aldehydes

........................... 100-40-3 4-vinylcyclohexene '

.................... Designated

............................... 11/90

143-33-9 sodium cyanide' 1 5
................... . .. Designated

................................ 11/90

79-10-7 acrylic acidl'

..................................... Designated

.............................. 11/90

98-86-2 acetophenone s

................................. Designated

............................... 11/90

108-95-2 phenol l

. 1 1'

................. Designated-____...

__ 11/90

121-69-7 NN-dimethylaniline'

....................... Designated

................................ 11/90

141-78-6 ethyl acetate

...................................... Designated

.............................. 11/90

576-26-1 2,6-dimethylphenol

........................... Designated

................................ 11/90

....................................................... Recommended with-Intent- 11190 to-designate Chemical fate: Aqueous volatilization rate. Health effects: Pharmacokinetics and oncogenicity by inhalation route of administration. Ecological effects: None.
Chemical fate Soil sorption. Health effects: Under review, as cyanides. Ecological effects: Toxicity to migratory birds,

plant uptake and translocation.
Chemical late: River die-away biodegradation. Health effects: Reproductive effects, developmental toxicity, mutagenicity, neurotoxicity and inhalation oncogenicity. Ecological effects: None.
Chemical fate: None Health effects: Oral and inhalation pharmacokinetics, inhalation subchronic, reproductive effects, developmental toxicity, mutagenicity, and neurotoxicty. Ecological effects: None.
Chemical late: None. Health Effects: Oral and Inhalation pharmacokinetics, Inhalation subchronic, reproductive effects, and neurotoxicty. Ecological effects: None.
Chemical fate: Activated sludge biodegradation. Health effects: Oral and inhalation pharmacokinetics, inhalation auibchronic, mutageniclty, reproductive effects, developmental toxicity, and neurotoxicity. Ecological affects. Algal toxicity, aquatic Invertebrates acute and chronic toxicity, and fish chronic toxicity.
Chemical fate: None. Health effects: S reening for reproductive effects, developmental toxicity. mutagenicity and neurotoxicity. Triggering oncogenicity. Ecologicaleffects: None.
Chemical fate: Aqueous photolysis screening

and river die.away blodegradation. Health effects: Screening for reproductive effects, developmental toxicity, mutagenicty and neurotoxicity. Ecological effects: Algal toxicity, aquatic invertebrate and fih chronic toxicity.
Chemical fate: None. Health effects: None. Ecological effects: Algal toxicity, aquatic inver.

tebrates acute and chronic toxicity and fish chronic toxicity. 

### 9535

### 9536 Federal Register / Vol. 56, No. 44 / Wednesday, March 6, 1991 / Notices

TABLE 1.-REVISIONS TO THE SECTION 4(E) PRIORITY 

### UST-Continued

Group CAS No. Chemical Action Date Recommended tests

IRIS

....................................... 51-28-5 2,4-dinitrophenol2-3

......................... Recommended

.......................... 11/90 Chemical fate: Aqueous photolysis screening and river die-away biodegradation. Health effects: Oral and inhalation pharmacokinetics, dermal absorption, inhalation subchronic, reproductive effects, developmental toxicity, mutagenicity, and neurotoxicity. Ecological effects: Aquatic invertebrates and

fish chronic toxicity. IRIS

....................................... 95-65-8 3,4-dimethylphenol

........................... Recommended

.......................... 11/90 Chemical fate: Aqueous photolysis screening and river die-away biodegradation. Health effects: Subchronic, screening for reproductive effects, developmental toxicity, mutagenicty and neurotoxicity. Ecological effects: Algal toxicity, aquatic invertebrates and fish chronic toxicity. 90-30-2 N-phenyl-l-naphthylamine

............... Recommended

.......................... 11/90 Chemical fate: Water solubility- octanol-water partition coefficient vapor pressure and biodegradation. Health effects: Oncogenlcity. Ecological effects: Algal toxicity, aquatic invertebrates and fish chronic toxicity. Sulfones

....................................................................................... Recommended

.......................... 11/90 Chemical fate: Physical and chemical properties. Health effects: None. Ecological effects. None. Substantially produced

........................................................ Recommended

.......................... 11/90 Chemical fate: None.

chemicals in need of Health effects: Subchronlc toxicity. subchronic tests. Ecological effects. None.

'Superfund Amendments and Reauthorization Act (SARA) section 110. 'Emergency Planning and Community Right-to-Know Act (EPCRA) section 313. 'Clean Air Act Amendments, section 301. 4 Toxic Substances Control Act (TSCA) section 8(a) Preliminary Assessment Information Rule (PAIR). 5TSCA section 8(d) Health and Safety Data Reporting Rule.



### Listed below are the individual chemicals for the chemical groups in Table 1. Chemicals nos. I through 89 are aldehydes, chemical nos. 90 through 115 are sulfones, and chemicals nos. 116 through 150 are substantially produced chemicals in need of subchronic tests.

Chemical Name CAS No. Notes

1. i-napninalenecarooxalaenyoe

........................................................................................................... 2. acetaldehyde

........................................................................................................................................ 3. acetaldehyde, trichloro-

....................................................................................................................... 4. propanal, 2-methyl-

.............................................................................................................................. 5. 2-propenal, 2-methyl-

.......................................................................................................................... 6. benzenepropanal, 4-(1,1-dimethylethyl)..a.-methyl-.

................................................................. 7.acetaldehyde, (1,3-dihydro-1,3,3-trimethyl-2H-indol-2-ylidene)

....................................................... 8. benzaldehyde, 2-chioro-

...................................................................................................................... 9. benzaldehyde, 2-hydroxy-.

................................................................................................................. 10. benzaldehyde, 2,5-dimethoxy-

......................................................................................................... 11. benzeneacetadehyde, .a.-methyl-

.................................................................................................. 12. bonzaldehyde, 2,4-dihydroxy-.

.......................................................................................................... 13. benzaldehyde, 2-hydroxy-5-nitro

..................................................................................................... 14. 2-furancarboxaldehyde

...................................................................................................................... 15. 2-thiophenecarboxaldehyde

.............................................................................................................. 16. benzaldehyde, 4-(dimethylamino)-.

.................................................................................................. 17. 3-cyclohexene-1-carboxaldehyde

.................................................................................................... 18. benzaldehyde

..................................................................................................................................... 19. 2-propenal, 2-methyl-3-phenyl-.

....................................................................................................... 20. octanal, 2-(phenylmethylene)-.

......................................................................................................... 21. benzenepropanal, .a.-methyl-4-(1-methylethyl)-

............................................................................ 22. benzeneacetaldehyde, 4-methyl-.

.................................................................................................... 23. 2-propenl, 3-phenyl-

........................................................................................................................ 24. benzaldehyde, 4-methyl-.

.................................................................................................................. 66-77-3
75-07-0 b
75-87-6
78-84-2 b
78-85-3
80-54-6
84-83-3
89-98-5
90-02-8
93-02-7
93-53-8
95-01-2
97-51-8
98-01-1 d
98-03-3
100-10-7
100-50-5
100-52-7
101-39-3
101-86-0
103-95-7
104-09-8
104-55-2
104-87-0

### Federal Register / Vol. 56, No. 44 

## 1 Wednesday, March 6, 1991 / Notices

Chemical Name

25 benzaldehyde. 4-chloro-

.................... 26. 6-octenal, 3,7-dimethyl-

.................... 27. 2,6-octadienal, 3,7-dimethyl-. (Z)-...
28. 5-heptenal, 2,6-dimethyl.

.................

zu. z-propenai

............ .............................................................................................................................. 30. acetaldehyde, chloro-

....................................................................................................................... 31. ethanedial

...........................................................................................................................................
32. octanal. 7-hydroxy-3,7-dim ethyl-

................................................................................................... 33 undecanal, 2-methyl-

........................................................................................................................ 34 pentanal

............................................................................................... : .............................................. 35. pentanedial

........................................................................................................................ 36. heptanal

.............................................................................................................................................. 37.decanal
................................................................................................................................................ 38. undecanal

........................................................................................................................................... 39. 10-undecenal

...................................................................................................................................... 40 dodecanal

......................................................................................................................................... 41. benzaidehyde, 3,4-dim ethoxy

........................................................................................................ 42. benzaldehyde, 4-(diethylamino)-.

................................................................................................... 43. 1,3-benzodioxole-5-carboxaldehyde

................................................................................................ 44. benzaldehyde, 3-ethoxy-4-hydroxy-.

............................................................................................... 45. benzatdehyde, 4-hydroxy-3-methoxy-

............................ 46. heptanal, 2-(phenylmethylene)-

...................................................................................................... 47. benzeneacetaldehyde

....................................................................................................................... 48. hexanal, 2-ethyl

............................................................................................................................ 49. benzaldehyde. 4-hydroxy-.

............................................................................................................... 50. benzaldehyde, 4-methoxy-.

............................................................................................................... 51. propanal

............................................................................................................................................. 52. octanal.............................................................................................................................................- 53. nonanal

........................................................................................................................................... 54. 4a(4H)-dibenzofurancarboxaldehyde,
55. benzaldehyde,2-methoxy-

.................. 56. 2,6-octadienal,3,7-dimethyl., (E)-.

...... 57. 9-undecenal

........................................... 58. benzaldehyde, 4-(trifluoromethyl)-.

..... 59. 2-hexenal

............................................... 60. benzaldehyde, 2-nitro-

......................... 61. butanal, 3-methyl-.

............................... 62. propanal, 3-hydroxy-2,2-dimethy

...... 1,Sa,$,9,fta, iexahydro-.

............................................. .

......................................................................................

...................... ...................................................

, L IU II I, U l

. .

........................................................ 64. 2-pyridinecarboxaldehyde

................... . . . ............... " 65. benzaldehyde, 4-butyl-.

................................................................. . 66. 2-propenal, 3-phenyl-, monopentyl deriv.
67. benzaldehyde, methyl-

............................... 68. 3-cyclohexene-l-carboxaldehyde. 2,4,6-t 69. 2-propenal, 3-(2-methoxyphenyl)-.

........... 70. 1-piperidinecarboxaldehyde

....................... 71. benzaldehyde,3-bromo-

............................ 72. propanal, 3-(methythio)-

............................ 73. octanal. 7-methoxy-3,7-dimethyl-.

............. 74. 3-cyclopentene-l-acetaldehyde, 2,2,3-trir
75. hexanal, 3,5,5-trimethyl-.

.......................... 76. 1,3-benzodioxole-5-carboxaldehyde, 7-m
77. 6-octenal, 3,7-dimethyl-, (S)-.

.................. 78. octanal, 3,7-dimethyl-.

............................... 79. benzaldehyde 4-ethoxy-.

.......................... ....... . .................................... ....... . . . . . . . methyl-

.............................................

eth.y.

....................................... ...... ........... ........ . ...................

............................. CAS No. 

### 9537

Notes



### ................................................................................................

................................ I

...............................................................

........ .................................................................................. 104-88-1
106-23-0
106-26-3
106-72-9
107-02-8 &,b
107-20-0
107-22-2
107-75-5
110-41-8
110-62-3
111-30-8
111-71-7
112-31-2
112-44-7
112-45-8
112-54.-

120-14-9 120-21-8
120-57-0

121-32-4
121-33-5
122-40-7
122-78-1
123-05-7
123-08-0
123-11-5
123-384 b
124-13-0
124-194
126-15-8
135-02-4
141-27-5
143-14-8

455-19M 505-57-7
552-89-6
590-86-3 597-31-9
939-97-9 d,e

1121-60-4 1200-14-2

1331-92-6 1334-78-7
1423-46-7
.1504-74-1
2591-86-8
3132-99-8
3268-49-3
3613-30-7
4501-58-0
5435-64-3
5780-07-4
5949-05-3
5988-91-0
10031-82-0

### Federal Register / Vol. 56, No. 44 / Wednesday, March 6, 1991 

## / Notices

Chemical Name CAS No.

80. 2-propenal, 3- 4-(1,1-dlmethylethyl)phenyl .2-methyl-.

.................................................................. 81. benzaldehyde, 4-(diethylamlno)-2ohydroxy-.

.................................................................................. 82.hexenal, 2-ethyl-
................................................................................................................................. 83. 3-cyclohexene-l-carboxaldehyde, dim ethyl

............................................................................ 84. benzaldehyde, (dimethylamino)-.

..................................................................................................... 85. 3-cyclohexene-l-carboxaldehyde, 4-(4-hydroxy-4-methylpentyl)-.

............................................... 86. 3-cyclohexene-l-carboxaldehyde, 4-(4-methyl-3-pentenyl)

.......................................................... 87. benzaldehyde, 3-phenoxy.

............................................................................................................... 88. 3-cyclohexene-l-carboxaldehyde, 1-methyl-4-(4-methyl-3-pentenyl).

........................................ 89. 3-cyclohexene-l-carboxaldehyde, 1-methyl-4-(4-methylpentyl)-.

................................................. 90. dimethylsulfone

................................................................................................................................. 91. suffolene

.............................................................................................................................................. 92. sulfonyt bis-(4-chlorobenzene)

......................................................................................................... 93. 4,

94. 4'-diaminodiphenyl sulfone

............................................................................................................ oisphenol S

......................................................................................................................................... 95. 2-amino-4-(metnylsultonyl)pnleno

.................................................................................................... 96. sulfolane

.............................................................................................................................. . 97. diphenylsulfone

.................................................................................................................................. 98. 2.2'-sulfonvl bis-ethanol

................................................................................................................... 99. 1. .1'-M ethylene bls(sulfonyl)]bisethene

...; .............................................................................. 100. 2-[(3-amlnophenyl)sulfonylethanol

.............................................................................................. 101. 3-[N-ethyl-4-[[6-(methyfsulfonyl)-2-benzothiazolyl]azo]-m-toluldino]-proponitrile

................ 102. 6-(methylsulfonyl)-2-benzothiazolamlne

....................................................................................... 103. 2-amino-4-[(2-hydroxyethyl)sulfonyl]pheno

..................................... 104. 4-phenylthiomorpholine

.1 1dioxide

.............................................................................................. 105. 4-[4-(2,6-dichloro-4-nitrophenyl)azo]phenyl]thlomorpholine, 1,1-dioxide-

............................ 106. 3-(decyloxy)tetrahydrothiophene 1,1-dioxide

................................................................................ 107. 1-(diiodomethyl)sufonyl-4-methy benzene

.................................................................................. 108. 1,1'-[oxybis(methylenesulfonyl)] bisethene

................................................................................. 109. 2,2'-Eoxybis(methylenesulfonyl)] bisethanol

..................................... :

.................................... 110. 1,l'-[m thylenebis(sufonyl)] bls-2-chloroethane

........................................................................ 111. 2,2'-[methylenebis(suffonyl)] bisethanol

...................................................................................... 112. 2-[(3-nitrophenyl)sulfonyl] ethanol

................................................................................................ 113. 2-[(6-amlno-2-naphthalenyl)sulfony] ethanol

.............................................................................. 114. 1,1'-[oxybis(m ethylenesulfonyl)] bis-2-chloroethane

.................................................................. 115. 4-[[4-(phenylmethoxy)phenyl]sulfonyl] phenol

........................................................................... t16. p,p'-oxybis(benzenesulfonylhydrazide)

.......................................................................................... 117. naphthalenedicarboxyltc anhydride

............................................................................................... 118. 2-ethylanthraquinone

....................................................................................................................... 119. 7-amino-4-hydroxy-2-naphthalenesuffonic acid

............................................................................ 120. 1-naphthol

........................................................................................................................................ 121. 3-hydroxy-2-naphtholc acid

............................................................................................................ 122. triethylene glycol bis(2-ethylhexanoate)

.............................................. .............................. . 123. 2-(4-morpholinyldithio)-benzothlazole

..................................................................... I

...................... 124. n-butyl methacrylate

........................................................................................................................ 125. 1,3-benzenedisuffonic acid

............................................................................................................. 126. 3,4-dichloronftrobenzene

................................................................................................................. 127. isophthaloyl chloridde

........................................................................................................................ 128. terephthaloyl chloide

...................................................................................................................... 129. 4-ethoxynitrobenzene

...................................................................................................................... 130. acetoacetanilide

............................................................................................................................... 131. butyric anhydride

.......................................................................... t

.................................................. 132. isobutyl acrylate

.............................................................................................................................. 133. diethylene glycol dimethyl ether

.................................................................................................... 134. carbinol acetate

............................................................................................................................... 13586-68-0
17754-90-4
-26266-68-2
27939-60-2

28602-27-9
31906-04-4
37677-14-8
39515-51-0
52475-86-2
66327-54-6
67-71-0
77-79-2
80-07-9
80-08-0
80-09-1
98-30-6
126-33-0
127-63-9
2580-77-0
3278-22-6
5246-57-1
16588-67-3
17557-67-4
17601-96-6
17688-68-5
17741-62-7
18760-44-6
20018-09-1
26750-50-5
36724-43-3
41123-59-5

41123-69-7 41687-30-3

52216-35-6
53061-10-2
63134-33-8

80-51-3
81-84-5
84-51-5
87-02-5

90-15-3 92-70-6
94-28-0
95-32-9
97-8-1 c,d
98-48-6
99-54-7

99-63-8
100-20-9
100-29-8
102-01-2
106-31-0
106-63-8 c 111-96-6
112-15-2 

### 9538

Notes

4

### Federal Register / Vol. 56, No. 44 / Wednesday, March 6, 1991 / Notices3

Chemical Name CAS No. Notes

135.bromamnine acid

................................................................................................................... ........... 116-81-4
136.4-methyl-2-nitro-phenol

.................................................................................................................. 119-33-5
137.4-(acetylamino) benzenesulfonyl chloride

.................................................................................... 121-80-8
138. 2,4-pentanedione

............................................................................................................................ 123-54-6

139. propanoic anhydrdde

....................................................................................................................... 123-62-6
140. bis(2-ethylhexyl)-2-butenedioate

................................................................................................... 142-16-5

141. peiIluorotributylamine

................................................................................ 311-89-7
142. perfluoro-N-hexane

.......................................................................................................................... 355-42-0
143. trichlorom ethanesulfenyl chloride

.................................................................................................. 594-42-3

144. 1,2-dichlorobutane

......................................................................................................................... 616-21-7 145. 1,3-dicyanobenzene

..................................................................................................................... 626-17-5
146. 3,4-dichlorobutene

......................................................................................................................... 760-23-6
147. 2-(2-aminoethoxy)-ethanol

.............................................................................................................. 929-06-6
148. quinac do

.................. n.i................................................................................................................ 1047-16-1
149. ammonium carbam te

................................................................................................................... 1111-78-0
150. hexatmethoxymethyl) m elamine

................................................................................................ 3089-11-0

Notes:

a. Superfund Amendments and Reauthorization Act (SARA) section 110.

b.Emergency Planning and Community Right-to-Know Act [EPCRA] section 313.

c.Toxic Substances Control Act [TSCA) section 8(a) Preliminary Assessment Information Rule (PAIR).

d.TSCA section 8(d) Health and Safety Data Reporting Rule.
TSCA Interagency Testing Committee StatutoryMemberAgencies andTheir Representatives: Council on Environmental Quality

Under consideration Department ofCommerce

Raimundo Prat Environmental Protection Agency

Letitia Tahan, Member Vincent Nabholz, Alternate National Cancer Institute

Susan Sieber, Member (See Note 1) Thomas P. Cameron, Alternate National Institute ofEnvironmental Health Sciences

James K. Selkirk, Chairperson National Institute for Occupational Safety and Health

Robert W. Mason, Member Rodger L Tatken, Alternate National Science Foundation

William L. Pengelly, Member (See Note 2)

Jarvis L. Moyers, Alternate Occupational Safety and Health Administration

Loretta Schuman, Vice-Chairperson Stephen Mallinger, Alternate Liaison Agencies and Their Representatives Agency for Toxic Substances and Disease Registry

Deborah Barsotti Consumer Product Safety Commission 

### Lakshmi C.Mishra Department ofAgriculture

Richard M. Parry, Jr. Elise A. B. Brown Department ofDefense

Harry Salem Melvin E. Anderson Department ofthe Interior

Clifford P.Rice Barnett A. Rattner Department ofTransportation

James O'Steen George Cushmac (See Note 3) Food and Drug Administration

Charles J.Kokoski Raju Kammula National Library ofMedicine

Vera Hudson National Toxicology Program

Miriam Davis (See Note 4) Victor A. Fung (See Note 5) U.S. International Trade Commission

Edward Matusik James Raftery Committee Staff

John D. Walker,Ph.D., Executive Director

Norma S. L. Williams, Executive Assistant Support Staff

Alan Carpien -- Office ofthe General Counsel, EPA

Notes: (1) Appointed on 

### July 25,1990. (2) Appointed on August 29, 1990. (3) Appointed on May 24, 1990. (4) Appointed on September 18,1990. (5) Appointed on September 18,1990.
The Committee acknowledges and is grateful for the assistance and support Given by the staff ofSyracuse Research Corp. (technical support contractor) and personnel ofthe EPA Office ofToxic Substances. Chapter1-Introduction
1.1 Background. Congress created the Interagency Testing Committee under the Toxic Substances Control Act (TSCA) to recommend to the Administrator ofthe U.S. Environmental Protection Agency (EPA) chemical substances and mixtures in commerce that should be given priority testing consideration. TSCA specifies that the Committee's recommendations shall be in the form ofa Priority Listpublished in the Federal Register.

At least every 6months, the Committee revises the Priority List and transmits these revisions to the EPA Administrator. The Committee's testing recommendations are described in previous reports (Refs. 1 through 11).

1.2 Committee'spreviousreports. Twenty-six previous reports to the EPA Administrator have been issued by the Committee and published in the Federal Register. In these 26 reports, the Committee has recommended testing for 91 chemicals and 28 chemical groups.

1.3 Committee'sactivitiesduringthis reporting period.Between April 26, 1990 and September 27, 1990 the Committee processed chemicals that were nominated by Member Agencies, evaluated chemicals by using the Committee's computerized, substructure-based, chemical selection processes and examined lists ofongoing activities related to reducing testing information deficiencies for commercial chemicals.

1.3.aNominationsandselections. Member-Agency nominations for this Report include N-phenyl-1- naphthylamine (Occupational Safety and Health Administration), Integrated Risk Information System (IRIS) 

### 9539

### Federhl Register,/ Vol. 56, No. 44 / Wednesday, March0, 1991 / Notices

chemicals and aldehydes (theU.S. Environmental Protection Agency).

Nominating chemicals to the Committee offers several advantages that appear to satisfy the intentions of Congress when they created the ITC. The nominator is provided with the unique opportunity to utilize the Committee-activated networking and information exchange processes that allows the nominator to access otherwise unavailable information from Member Agencies. Committee networking is important because it allows the nominator to determine if there are unpublished studies that could satisfy the nominator's testing information deficiencies or that could provide the nominator with additional testing concerns. Information exchange is important at the Committee level because it isnot limited to a single type oftesting,but includes comprehensive discussions ofhealth effects, chemical fate and ecological effects testing.It allows the nominator to save resources by analyzing only essential testing information deficiencies, while the Committee comprehensively addresses other testing information deficiencies without substantive delays inprocessing nominations.

Nominating chemicals to the Committee also allows the nominator to take advantage ofan unusual information-collecting opportunity that only exists for Committee recommendations. For any chemical or chemical grouprecommended by the ITC, theEPA automatically promulgates TSCA 8(a) and 8(d) final rules.TSCA 8(a) requires that industry submit manufacturing, importation and exposure data for any chemical listed in

a final section 8(a) rule. TSCA 8(d) requires that industry submit all health effects, epidemiology, medical case studies, monitoring, chemical fate and ecological effects studies for any chemical listed in a final section 8(d) rule. TSCA section 8(a) and 8(d) data

aregenerated in 3months through an ITC recommendation in contrast to 18 to 24 months through conventional notice and comment rulemaking. The resulting TSCA section 8data are analyzed and a report is generated for the nominator that indicates whether any ofthe data submissions are likely to satisfy the nominator's testing information deficiencies.

Chemical group selections for this Report include sulfones and substantially produced chemicals in need ofsubchronic tests. Sulfones and substantially produced chemicals in need ofsubchronic tests were identified by using the Committee's computerized, substructure-based, chemical selection processes. The substantially produced chemicals in need of subchronic tests selection exemplifies a feature ofthese processes that is being utilized for the first time, i.e., the ability ofthe processes to identify agroup of chemicals that have a common testing information deficiency. This costeffective feature should allow EPA to add those identified chemicals that satisfy the TSCA section 4 statutory requirements [and for which TSCA section 8 information does not reduce the need to consider subchronic toxicity testing] to a subchronic toxicity listing rule and should provide others (e.g., NTP, OECD, etc.) with the option of selecting any ofthe remaining chemicals for testing.

The Committee uses their computerized processes to enhance their ability to cost-effectively screen chemicals for exposure potential or potential topersist and cause adverse health or ecological effects by: (1) Identifying chemical groups with identical substructures and similar adverse effects potentials ,orchemical fate characteristics, (2) identifying chemical groups with similar uses or
common testing information deficiencies and (3)recommending chemical groups, with insufficient test data, for health effects, chemical fate, orecological effects testing. The Committee continues to recommend groups ofstructurally- or use-related chemicals orgroups with

common testing information deficiencies for screening tests and toreview the TSCA section 8(a) and 8(d) information that is submitted in response to recommendations. The Committee believes recommending groups of structurally- or use-related chemicals or groups of chemicals with common testing information deficiencies for screening tests and reviewing TSCA section 8(a) and 8(d) information before making subsequent testing recommendations is a cost-effective approach to'satisfying chemical testing Information deficiencies because it promotes a comprehensive analysis of chemicals that may produce similar effects orthat may involve similar exposures. The Committee processes external nominations of structurally- or use-related chemical groups or groups with common testing information deficiencies and encourages external nominators to take advantage ofthe Committee's unique networking and information exchange processes and accelerated TSCA 8ka) and 8(d) information-collecting authority.

Processing and recommending Member-Agency and other nominations 

### and computer-facilitated chemical group selections enhances information exchange that promotes cost-effective

use ofU.S. Government chemical testing resources, encourages harmonization of methods for chemical testing, and facilitates coordination oftesting being sponsored orrequired by U.S. Government organizations.

1.3.b Comprehensiveinformation processing.During this reporting period, several For Your Information (FYI). TSCA section 8(d) and 8(e) documents
were reviewed. These documents are stored on microfiche in the TSCA Public Docket Office, Office ofToxic 

### Substances, Environmental Protection Agency, Room G-04 NE Mall,401 M St., SW., Washington, DC 20460. These microfiched documents are also available from the National Technical information Service, 5285 Port Royal Road, Springfield, Virginia 22161 (1-800- 336-4700), and from Chemical Information Systems, Inc., 7215 York Road, Baltimore, Maryland 21212 (1- 800-CLS-USER). The Committee 

### referenced several ofthese documents in Chapter 2ofthis report and readers

are referred to the above addresses to obtain further information. Interested parties can also obtain,from the EPA address, copies ofpublicly-available reports, letters and published references supporting recommendations of chemicals in this report.

The Committee continues to comprehensively search available domestic and international listsof ongoing activities related to reducing testing information deficiencies on chemicals under review. Efforts to conduct these searches identified chemicals listed in other statutes,e.g.. chemicals listed in Title IIIofthe 1990 amendments ofthe Clean AirAct. The Committee has recommended over 50 chemicals listed in this statute, including 5Iris chemicals for inhalation testing (acrylic acid, acetophenone, phenol. 2.4- dinitrophenol andNN-dimethylaniline). The Committee continues to review information on chemicals listed in this and other relevant statutes. Efforts to conduct searches alsoidentified chemicals forwhich TSCA informationgathering activities are ongoing (see Table I footnotes). The Committee makes the results of these searches publicly available by referencing TSCA submissions in Reports to the EPA Administrator ormaking tables and references ofthese submissions available in the public dockets supporting a Report to the EPA Administrator.

During this reporting period, the Committee considered available 

### 9540 9540

### Federal Register / Vol. 56, No. 44 

## / Wednesday, March 6, 1991 / Notices

information on 3 chemicals and over 30 chemical groups. Chemical groups currently under consideration include alkenes, alkylamines, alkylnitros, alkylsulfonates, alkynes, anhydrides, aromatic dianhydrides, aromatic sulfhydryls, aromatic sulfonates, aryl ethers, benzothiazoles, carbamates, dialkylamines, ethanolamines, epoxides, ethylhexyl derivatives, glycol ethers, haloalkyl ethers, heterocyclics, hinderd phenols, hydrazines, inorganics, isophthalic acids, isothiocyanates, nitriles, phenylenediamines, phosphates, phosphoniums, pyrrolidinones, siloxanes, sulfenamides, thiocarbamates, thiol esters, thios, triazines, etc. The Committee designated two chemicals that were recommended with intent-to-designate in the 25th and 26th, Reports. One chemical and four chemical groups were selected for addition to the section 4(e) Priority List. Review ofthe remaining chemicals and chemical groups is ongoing.

1.3.c Informationdissemination. To emphasize the Committee's efforts to 

### promote public understanding ofthe ITC's functions and purposes, the Committee is listing for the first time

some of the Committee-related activities thatoccurred during this reporting period. On June 20, 1990 the Committee's Executive Director testified before the House Subcommittee on Environment, Energy and Natural Resources. On June 29, 1990, during an information exchange symposium, the Committee's Chairperson and Executive Director presented chemical selection procedures used by the National Toxicology Program (NTP) and the ITC. On July 2 and September 7,1990, the Executive Director briefed the Synthetic Organic Chemical Manufactures Association and the Chemical Manufactures Association, respectively, on ITC activities. On September 20, 1990, the Executive Director described the ongoing efforts to evaluate the ITC's substructure-based computerized chemical selection processes at an international workshop convened in the Netherlands. 1.3.d Deferrals.To promote public understanding of the total number of chemicals that the Committee processes, the Committee islisting for the first time about 700 chemicals in 4 chemical groups that are being deferred from further consideration at this time because the chemicals were not reported to the EPA or the U.S. International Trade Commission as being recently produced. Four IRIS chemicals (ammonium sulfamate, CFC113, HMX and hydrogen sulfide) are also being deferred; the rationales for which for which are described in section 2.2.c. ofthis Report. Deferred and other chemicals are recycled through the Committee's computerized processes to identify chemicals whose production volumes have substantially changed. On the following list ofdeferrals, chemicals

no 1 through 429 are aldehydes, chemicals no 430 through 525 are brominated flame retardants, chemicals

no 526 through 605 are isocyanates and chemicals 606 through 686 are sulfones.

Chemical Name CAS No.

4-pyridinecarboxaldehyde, 3-hydroxy-2-methyt -0- LLw f l g wfnu InuXV me J

- . ........................................................................................................................... 4-pyridinecarboxaldehyde, 3-hydroxy-5-(hydroxymethyl)-2-methy-, hydrochloride hexanal

............................................................................................................................. 2-furancarboxaldehyde, 5-(hydroxymethyl)-

............................................................... acetaldehyde, trifluoro-

................................................................................................... propanal, 2-oxo

.............................................................................................................. acetaldehyde, dichloro-

.................................................................................................. 1H-pyrrole-3-carboxaldehyde, 2,5-dimethyl-l-phenyl-

............................................... benzaldehyde, 2,6-dichloro-

........................................................................................ UItdr MIUWnydu, .qa-tnMetrnoxy-.

.................................................................................................................................................................................................. 2-butenoic acid. 2.3-dichloro-4-oxo-, (2)-.

................................................................................................................................................................................... 3-cyclohexene-1-carboxaldehyde, 6-methyl

............................................................................ ................................................................................................... benzaldehyde. 3,5-dichloro-2-hydroxy-.

....................................................................................................................................................................................... benzaldehyde, 4-[(2-chloroethyl)ethylam lno]-2-m ethyl-

........................................................................................................................................................... benzaldehyde, 4-(diethylamino)-2-methyl

..................................................................................................................................................................................... benzaldehyde, 4-[(2-chloroethyl)methylamino -.......................................................................................................................................................................... butanal, 2-methyl-.

........................................................................................................................................................................................................................... butanal, 2-ethyl.

............................................................................................................................................................................................................................... benzaldehyde, 3-nitro-.

.................................................................................................................................................................................................................... benzeneacetaldehyde, a, 4-dimethyl

......................................................................................................................................................................................... benzaldehyde, 3-hydroxy......................................................................................................... ;
...................................................................................................... benzenepropanal

............................................................................................................................................................................................................................ undecanal, 2,6,10-trimethyl-.

......................................................................................................................................................................................................... butanal, 3-hydroxy..

.......................................................................................................................................................................................................................... acetaldehyde, tribromo-

................................................................................................................................................................................................................. 1, 3-cyclohexadiene--carboxaldehyde, 2,6,6-t .methyl-

............................................................................................................................................................. benzaldehyde, 4-ethoxy-3-methoxy-.

.......................................................................................................................................................................................... benzaldehyde, 4-(1-methylethyl)-.

................................................................................................................................................................................................. pentanal, 2-methyl-

......................................................................................................................................................................................................................... 2-butenal, (E)-.

....................................................................................................................................................................................................................... . tetradecanal

......................................................................... benzaldehyde, 4-hydroxy-3,5-dimethoxy-.

....................... 9-undecenal, 2,6,10-trimethyl

.......................................... 7-octenal, 3,7-dimethyl-.

.................................................... 2, 4-hexadienal, (E E)-.

..................................................... benzaldehyde, 2-hydroxy-3-methoxy.

.............................. benzaldehyde, 2-chloro-6-fluoro-

...................................... 2-cyclohexene- -carboxaldehyde, 2,6,6-trimethyl-.

......... 1-cyclohexene-l-carboxaldehyde, 2,6,6-trimethyl-

.......... benzaldehyde, 3-(trifluoromethyl).

.................................... benzaldehyde, 3-fluoro-

..................................................... benzaldehyde, 4-fluoro-

..................................................... 2-cyclohexene-1-acetaldehyde. 2,6,6-trimethyl-

.............. 1-cyclohexene-l-acetaldehyde, 2,6,6-trimethyl-.

............. retinal, 13-cis-

..................................................................... 54-47-7 56-82-6 65-22-5 66-25-1 67-47-0 75-90-1 78-98-8 79-02-7 83-18-1 83-38-5 86-81-7 87-58-9 89-04-1 90-60-8 92-10-4 92-14-8 94-31-5 96-17-3 97-96-1 99-61-6 99-72-9 100-83-4 104-53-0 105-88-4 107-9-1 115-17-3 11-26-7 116-31-4 120-25-2 122-03-2 123-15-9 123-73-9 124-25-4 134-96-3 141-13-9 141-26-4 142-83-6 148-53-8 387-45-1 432-24-6 432-25-7 454-89-7 456-48-4 459-57-4 472-64-0 472-66-2 472-6-6 ornpail, zo,-"atyurioxy-, t-r' . ........................................................................................................................................................................................................

...................................................................................................................

...................................................................................................................

...................................................................................................................

...................................................................................................................

...................................................................................................................

...................................................................................................................

...................................................................................................................

...................................................................................................................

............................................................................................................................ I

...............................

.............................................................................................................................................................

................................................................... I

.........................................................................................

.............. I

..............................................................................................................................................

............... I

......................................................................................................................................

.............................................................................................................................................................

.............................................................................................................................................................

.............................................................................................................................................................

.............................................................................................................................................................

............................................................................................................................................................. 

## 0541

I

### 9542 Federal Register / Vol. 56,No. 44 / Wednesday, March 6, 1991 

## / Notices

Chemical Name CAS No.

48. benzalde-y

., 2.4,8-trl.ethy.................................................... 487-68-3
50. benzaldehyde. 3-ethoxy-2-hydroxy-

... ... .............................................................................. ........... 492-88-6 51. hexanal, 2-ethyl-3-hydroxy.
.................................................................................................................................................................................. 496-03-7 52. 2-butenal, 2-methyl-, ( )
................ ................................... ... . . . . . ........................................................................................ 497-03-0 53. 3-thIoe r rboxaldehyde ---. ---.. ... ... ....

............................... ......................................................................................................................................... 498-62-4 54. 3-pyrtdinecarboxal e. ............. ......................................................... .........

. . .............................................................................. 500-22-1 55. 2, 6,10-dodecatrienak 3,7,11-trimethyl-, (EE).

. . .............. 502-67-0 56. retinal,9-cis-

. ........ ............................................................................................................ ................................ 514-85-2 57. be rzaidehyde, 2-amino-

................................................................................................................................................... 529-23-7 58. bernzaldehyde, 4-n o- .............................................................. .. .. . ......... . ............ . ..... 555-16-8 59. benzaldehyde, 4-amino-

.... . ........................................................................................................................................................................................ 556-18-3 60. 2,6-nonadienal, (E,Z)-.

...................................................................................................................................................................... ........................... : ..... 557-48-2 61. blcyvto[3.1.1 ]hept-2-ene-2-carboxaldehyde, 6,6-dimetyl

................................................................................................. 564-94-3 62. benzaldehyde, 3-m ethoxy...............................................................................................................................................................

...................................... 591-31-1 63. benzaldehyde, 2,4,6-t rnitro-

........................................................................................................................................................... ...... ............... 606-34-8 64. benzaldehyd 4-(d pro y.no)-

. . ... . ............................ ................... ...................................................................... 613-28-5 65. benzaldehyde, 2-othoxy-

................ ....

......................................... ...

....

........ ...... ....... ....

....

............... ....

......................................................................... 613-69-4 66. benzaldehyde, 2-hydroxy-5-mothy

................................................ . . . . . . . . . . .. 613-84-3

67. 2-kirancarboxaldehyde, 5-metli-....................................... 620-02-0 68. benzadehyde,3-methyl

.............. .......... .................................. ........................................... ............. 620-23-5 69. benzaldehyde,3-hydroxy-4-methoxy-.
................................................. . ..... ........................................................... ...... 621-59-0 70. 1, 4-benzenedicarboxaldehyde

.............................................................................................................................................................................................. 623-27-8 71. 2-propenal, 3-(2-furaryl)-

.... ....

................................. .................................................................................... ............................ ...

...... ...... ..... ..

....................... 623.-30-3 71. 2-propenal, 2

............................................................ ....... .......................... .... 623-36-9

74. hexadecanal
................................................................................................................................................................................................................... 629-80-1 75. propanal, 2,2-dimethyl-

.......................................................................................................................................................................................................... 630-19-3 76. benzaldehyde, 5-chloro.2.hydtoxy.
............................................................................................................................................................................................ 635-93-8 77. but.

. .. .8l.................................................... 638-37-9 78. 9-anthracenecarboxaldehyde

....................................................................................................................................................................................................... 642-31-9 79. 1, 2-benzened carboxaldehyde

..................................................................................................................................................................................................... 643-79-8 80. 2-hexenal, 2-ethyl-

.......................................................................................................................................................................................................................... 645-62-5 81. benzaldehyde, 2-hydroxy-4-methoxy-.

.......................................................................................................................................................................................... 673-22-3 82. 1-naphthalenecarboxaldehyde, 2-hydroxy

...................................................................................................................... .. ............. .......................... 706-0

- 5 83. 2-pentenal
.................................................................................................................................................................................................... ................................. 764-39-6 64. 2, 4-pentadienal

................. .. .... . ........................................................................... ............................ .... ....................... 764-40-9 85. 2-propenal, 2-methyl-3-[4-(1-m ethylethyl)phenyl]

. .................................................................................................................................................................... 831-97-0 86. 4-pyrdinecarboxaldehyde

......... ............................................................................................................................................. ... ............. ..... 872-85-5 87. benzaldehyde, 2,4-dichloro-

....................................................................................................................................................................................................... 874-42-0 88. 2-propenal, 3-(2-furany -2-methyl-

....................................................................................................................................................................................... 874-66-8 89. benzaldehyde, 4-(acetyloxy)-.

................................................................................................................................................................................ .... 878-00-2 90. benzaldehyde, 4-(acetyloxy)-3-methoxy-.

............................................................................................................. .. ..... 881-68-5 91. propanal, 2-chloro-2-m ethyl-

. . . . . ................................................................................................................................................................... 917-93- 1 92. 1H-pyrrole-2-carboxaldehyde

......................................... ....................................................................................................................... ... ........ ............... 1003-29- 93. benzeneacetaldehyde, 4-methoxy-a-oxo-

.................................................................................................................................................... .................. .. 1076-95-5 94. 8'-apo-,P, psi-carotenal.

........................................................................................................................................................... .... ...... ...... .............. 1107-26- 2 95. pentanal, 4-methyl.

.......................................................................................................................................................................... . ................................... 1119-16-0 96. 2-pyddinecarboxaldehyde, 6-methyl-

..... ............................................................................................................ .. ... . ....................... 1122-72-1 97. benzaldehyde, 4-bromo- .............................................................................................................................................. ...... ....................... 1122-91-4 98. benzaldehyde,2, 5-dihydroxy-

....................................................................................................................................... 1194-98-5

99. 1, 3-benzodioxole-5-propanal, .a.-methyl.

........................................................................................................................................................................ . . 1205-17-0 100. propanal, phenyl-

..................... .................................................................................................................... ........................................................................ ... 1335-10-0 101. hexenal
....................................................................................................................................................................................................................... ... 1335-39-3 102. benzeneacetaldehyde, ar-(1-methylethyl)-.

.................................................................................................................................... ... 1335-44-0 103. undecenal
........................................................................................................................................................................................................................... 1337-63-3 104. benzaldehyde,2-chloro.-4-(dim ethylamino)

................................................................................................................................................................... 1424-66-4 105. benzaldehyde, 3-amino-

.................................................................................................................................................................................. ... . ....... ....... .. 1709-44-0 106. 2-propenal, 3-(4-nitrophenyl)-.

................................................................................................................................................................................................ ... 1734-794 107. 1H-Indole-3-carboxaldehyde, 1-methyl-2-phenyl-.
...................................................................................................................................................................... 1757-72- 108. benzaldehyde, 5-bromo-2-hydroxy

........................................................................................................................... ...................................................... 1761-61-1 109. 2-propenal, 3-(4-mathoxyphenyl)-.

.................................................................................................................................................................................................. 1963-36-6 110. benzaldehyde, 3,4-diethoxy-.

..................................................................................................................................................................................................... 2029-94-9 111. 4-pentenal

.. .......................................................................................................................................................... . ............... 2100-17-6 112. benzaldehyde, 2,3,4-timet xy....................................................... 2.............................................................................................................................................. 2103-57-3 113. 1-cyclohexene-l-carboxal ehyde

, 4-(1-methytethenyl).

.............................. .......................................................................................................................... 2111-75-3 114. acetaldehyde, phenoxy-.
................................................................................................................................................................................................................ 2120-70-9 115. propanal, 3-hydroxy-.

.... ... .... . ................................................................................................................................... . ................................. 2134-29-4 116. benzaidehyde, 2,3,4-trhydroxy..

......................................................................................................................................................................... ...... .. ..... ....2144-08-3 117. benzaldehyde, 4-hydroxy-3, 5-dlm et -. .................................................................................................................................................................. 2233-18-3 118. 6-nonenal, (2)
................................................................................................................................................................................................................................ 2277-19-2 119. 2, 4-decadienal

...................................................................................................................................................................................... ...

.............................. 2363-88-4 120. 2-octenal
.......................................................................................................................................................................................................... ..... 2363-89-5 121. 6-octenal, 3,7-dim ethyl-, (R)- • ............................................................................................................................................. .... ............................ 2385-77-5 122. benzaldehyde, 2-hydroxy-3,5-dtnittro-

..................................................................................................................................... ........................................... 2460-59-5 123. 2-nonena!
.............................................................................................................................................................................................. .. ................ .............. 2463-53- 124. 2-heptenal

............................................................................................................................................................................................................ ........ ..... 2463-63-0 125. 2-undecenal
.............................................................................................................................................................................................................. . ... 2463-77-6 126. benzaldehyde, 4-ethoxy-3-hydroxy-.

.................................................................................................................................. ..... ..... . ............... 2539-53-9 127. 2-octenal, (E)-.

. . . .... .... ........................................ ...................................................................... ........... . ... ....... ......... ..... 2548-87-0 128. pentadecanal

.................................................................................................................................................................................................................................... 2765-11-9 129. benzaldehyde, 3-bromo-4-hydroxy-5-m ethoxy-.

............................................................................................................................................................................ 2973-76-4

### Federal Regi ter I Vol. 56, No. 44 / Wednesday, March 6, 1991 / Notices 9543

Chemical Name CAS No.

130. 2',ne al, 2--penty
.. .......................................................................................................................................................................................................................... 3021-89-4 131. 2- ute nal,2-,methy -4-(2,6,6-tuimeth l--oyc ahnen-1-y

- ** ................................................................................................................ .............. ........................... 3155-71-3 132. mdldehyld e , 4+tt)o)- .3........................................................................................................................................................................................................ 3446-89-7 133. 2- entenal, -methyl .-....................................................................................................................................................................................................................... 3592-19-6 134. p pata
, 8- d o y-2,2-bi(hydro ym ethyt)-

................................... ............................................................................................................................................. 3618-32-4 135. 2-decenal

......................................................................................................................................................................................................................................... 3913-71-1 136. 1.4-o e.' " az

... l

... j-' ;.yde

..................................................................................................................................................................................................... 4164-39-0 137. ben ade , , 4-fdi he ya i")-
........................................................................................................................................ ........................................................ 4181-05-9 138. 2
................................................................................ .......................................................................................................................... 4265-16-1 139. 2,44v ptadienal, *, ....................................................................................................................................................................................................................... 4313-03-5 140. benzenacetv ldehyde, 4-(1 met4ethy-)
........................................................................................................................................................................................ 4395-92-0 141. ldehyde 4-pheny t " ).
................................................................................................................................................................................................ 4397-53-8 142. b mteneacetadehyde, a-ethy dene-

......................................... ................................................................................................................................................... . 4411-89-. 143. e, e nal
............................................................................................................................................................................................................................................ 4440-65-7 144. beM z de yde
, 2.4,6-tr etho y-.

. ..................................................................................................................................................................................................... 4460-86-0 145. 44 al, (2y-
........ ........................................................................................................................................................................................................................ 4634-89-3 1415. benz yd
, 4-et yl-

..................................................................................................................................................................................................................... 4748-78-1 147. 2-d decen l

..................................................................................................................................................................................................................................... . 4626-62-4 148. 2,6,9,11 -dedec te e al, ,,10-tr ethyl
................................................................................................................................................................................... 4955-32-2 149. be zeneaoetale
, -(2-phenylethyldene)..

............................................................................................................................................................................ 5031-8 -4 150. be,-id-ehyde, L " xy 8-itro-

...................................................................................................................................................................... ........... 5274-70-4 151. 2-pentenal, 4-met
................................................. ................................................................................................................................................................... .. 5382-56-1 152. ber epenal, 4-methyl-

........................................................................................................................................................................................................... 5406-12-2 153. 14 ole- c, -me # ............................................................................................-.... h e 2-methyl-........................................

. . . . . . . . 5416-80-S 154. ben lde d
, 4-*jdmr y-8-lodo-8-methoxy-.

............................................................................................................................................... .. . . . 5438-36-8 155. 1 cycie[2.2.1]hept,5 e-2-c a e .. idehyde

............................................................................................................................................................. ......... 5453-80 1M6. benz dehyde, 4propoxy ................................................................................................................................................................................................................ 5735 -85- 157. ben dehyde, 4 buto y.. .................................................................................................................................................................................................................. 5736-88-9 158. b aldehy , ................................................................................................................................................ ....................................................... 5736-91-4 159. be zaldehyde, 4-(h xylm y)

............................................................................................................................................................................................................. 5736-94-7 160. 2. 4- eptadienal

................................................................................................................................................................................................................................. 5910-85- 1. 2 , 4-nonadiena
,(Ef)-

..................................................................................................................................................................................................................... 5910-87-2 1162. 2-ropenal, 844- m ethy m no)phe y - .. .......................... 6.......................................................................................................................................................... 6203- 18-5 3. bezaldeyde, 2,4-dihydroxy-3nethyl-.

................................................................................................................................................................................................ 6248-20-0 64. benzaldehyde, 3.4 dchloro-.

............................................................................................................................................................................................................ 8287-38-3 165. ,benzeehyde

. dich

........................................................................................................................................................................................................... 63 4-18-5 166. propenal, ld thy m )-2,2-dimethyl-.

.................................................................................................................................................................................. 6343-47-1 167. benzaldehyde, 2ch oro,- itro

...................................................... . . . ........................................................................................... ................. ............ 6361-21-3 168. 2-propenal, 2-methy"

- -( i-methyethy )ptieny -. ..................................................................................................................................................................... 6 02-23-4 169. 4-tex nsal, 5-methyl-2-(1-m ethylethenyt)-, (R )-.

............................................................................................................................................................................. 6544-40-7 170. benzaldehyde, 2t4r m o ................................................................................................................................................................................................................... 6630-33-7 171. ndecanal, 2-ethylidene-

................................................................................................................................................................................................................... 6720-16-7 172. 2-hexenal, (E)-

................................................................................................................................................................................................................................. 6728-26-3 173. 4-teptenal,

............................................................................................................................................................................................................................... 6728-31-0 174. 2, 4-,nonad e .al
................................................................................................................................................................................................................................. 6750-03-4 175. 3-tM xenal, (2)-.
.................................................................................................................................................................................................................................. 6769-80-6 176. benzalehyde, p tyj.

........................................................................................................................................................... ....... ......... . 0853-57-2 177. 2-propenal, 3-(1,3-benzodioxol 5-yl)-2-methyl-

............................................................................................................................................................................ 6974-47-6 178. 9,10-anthracenedicaf ox e ydehyde
................................................................................................................................................................................................. 7044-91-9 179. 2-thiophe e arboxaldehyde, 5-choro-. .......................................................................................................................................................................................... 7283-96-7 1 0. hexa al, 2- t t hy ne)-.

............................................................................................................................................................................. ........................ 7492-44-6 '1.

- e e , [(3, -dimethy -octeny )oxy]-.

............................................................................................................................................................................... 7492-67-3 182. 3-cyclohe l-e-1 carboxa dehyde, 4-4 ethyl-

....................................................................................................................................................... ........... 7560-64-7 163. 1-Mperazinecarboxa dehyde
.................................................................................................................................................................. ............... 7755-92-2 184. 2-trdecena7

....................................................................................................................................................................................................................................... 7774-82-5 1 5. octanal, 2-methyt-

.............................................................................................................................................................................................................................. 7786-29-0 1186. beren eacetatdehyde, 2-methyl-.

........................................................................................................................................................... ............... 10166-08-2 1 7. be aldehyde, 3, chho

.............................................................................................................................................................................................................. 10203-08-4 168. 1-naphthaem cetaldehyde, 5,6,7,8-tetrahydro-.

........................................................................................................................................................................... 10484-28 189. trindecanal

........................................................................................................................................................................................................................................... 10486-19-8 190. cyclohexanecarboxaldehyde, 2,2,6-trmethyt-.

................................................................................................................................................................................. 13155-57-2 1 1. 2,4-pentadienal, -pheny- ............................................................................................................................................................................................................... 13466-40-5 192. 2-thiophen carbox yde, 5-methyl

. ......................................................................................................................................................................................... 13679-70-4 193. 5-Wmidi ecarbwaldehyde, 4-amino- -chlro-.

............................................................................................................................................................................ 14160-93-1 194. 2-pentenal,2.,-m ethyl-, (E)-.

............................................................................................................................................................................................................. 14250-96-5 195. 1 -lndole-3-c rboxaldehyde, 1-methoxy-2'phenyl-.

.................................................................................................................................................................... 14960-63-5 196. propanal, 3,(dimethy anino)-2,2dimethyl-.

.................................................................................................................................................................................. 15451-14-6 197. propana ,2m ethyl-2.,(methytthio)-.

................................................................................................................................................................................................. 16042-21-0 T98. butanal, 3-t me j ho)-.
.................................................................................................................................................................................... 1 630-52-7 199. B-nonadienal, -(E C-)-

......................................................................................................................................................................................................................... 17587-3 " 200. 2,8 ,1 1-dodec atetral, 2.6,10-timethyl-, (E,E,E)-.

................................................................................................................................................................... 17909-77-2 201. 3-cy-carboxatdehyde, 2-(1-methylalt )
...................................................................................................................................................................... 18126-38-0 202. berenepropan l, 4-(1,1-direthylethyl)-.

...................................................................................................................................................................................... 18127-01-0 203. propanal, 3-t tyd xy-2-(hydroxymethy)-2-methyl

. ........................................................................................................................................................................ 18516-18-2 204. 2-beptena , (E)-......

......................................................................................................................................................................................... 18829-55-5 205. 2-nonenal, (E)-

................................................... ............................................................................................................................................................................... . 18 29-56-6 206. decanal, 2-methyl-.

.............................................................................................................................................................................................................................. 1900 -56-4 207. 2 utenal, 2-ethyl-.

.............................................................................................................................................................................................................................. 19780-25-7 208. nonanal. 2-be rzytidene-

................................................................................................................................................................................................................... 20175-19-3 209. 2-dodecenal, (E)-.
............................................................................................................................................................................................................................ 20

40

7-84-5 210. 2- ctenal,(Z)-.
.................................................................................................................................................................................................................................. 20064-46-4 211. cyc ohexanecarboxa ldehyde, 4-(1,1-d Tm ethylethyt)-.

.................................................................................................................................................................... 20691-52-5

### 9544 Federal Register / Vol. 56, No. 44 / Wednesday, March 6, 1991 / Notices

Chemical Name CAS No.

212. 7-decenal, (2)-.

................................................................................................................................................................................................................................... 21661-97-2 213. 4-decenal (2)-.

................................................................................................................................................................................................................................... 21662-09-9 214. 2,6-dodecadienal, (E,2)-.

................................................................................................................................................................................................................... 21662-13-5 215. 2,4-dodecadienal, (E,2)-.

................................................................................................................................................................................................................... 21662-15- -7 216. 2,4-dodecadienal, (E E)-.

................................................................................................................................................................................................................... 21662-16-8 217. benzeneacetaldehyde, a-(3-methylbutylidene)-

............................................................................................................................................................................ 21834-92-4 218. benzaldehyde, 4-(2-hydroxyethoxy)-.

.............................................................................................................................................................................................. 22042-73-5 219. 1H-pyrazole-4-carboxaldehyde, 3,5-dimethyl-l-phenyl-

................................................................................................................................................................ 22042-79-1 220. undecanal, 2-methylene-.

.................................................................................................................................................................................................................. 22414-68-2 221. decanal, 2-m ethylene-

........................................................................................................................................................................................................................ 22418-65-1 222. 6-octenal, 3,7-dimethyl-2-m ethytene................................................................................................................................................................................................ 22418-66-2 223. acetaldehyde, (methylthio)-.

............................................................................................................................................................................................................. 23328-62-3 224. 5,9-undecadienal, 2,6,10-trimethyl-

................................................................................................................................................................................................ 24048-13-3 225. benzaldehyde, 4-(octyloxy)-.

............................................................................................................................................................................................................. 24083- 13-4 22

. benzaldehyde, 4-azido-.

.................................................................................................................................................................................................................... 24173-36-2 227. pregn-4-ene-20-carboxaldehyde, 3-oxo-

........................................................................................................................................................................................ 24254-01-1 228. benzeneacetaldehyde, a-2-propeny

.............................................................................................................................................................................................. 24401-36-3 229. benzaldehyde, 2-m ethoxy.5.nitro

................................................................................................................................................................................................... 25016-02-8 230. 2-butenal, 2-[(acetyloxy)m ethyl]-.

................................................................................................................................................................................................... 25016-79-0 231. 2,4-decadienal, (EE)-

....................................................................................................................................................................................................................... 25152-84-5 232. hexanal, 2-ethylidene-

................................. ...................................................................................................................... 25409-08-9 233. butanal, 4-hydroxy-

........................................................................................................................................................................................................................... 25714-71-0 234. acetaldehyde, (3,3-dimethylcyclohexylidene)-, (2)..

....................................................................................................................................................................... 26532-24-1 235. acetaldehyde, (3,3-dimethylcyclohexylidene)-, (E)-.

...................................................................................................................................................................... 26532-25-2 236. benzeneacetaldehyde, a-(2-methylpropylidene)-.

......................................................................................................................................................................... 26643-91-4 237. benzaldehyde, 4-(heptyloxy)-.

.......................................................................................................................................................................................................... 27893-4 1-0 238. 2-pentenal, 2-ethyl-4-methyl-.

........................................................................................................................................................................................................... 28419-86- 5 239. butanal, 2-(phenylmethylene)-.

........................................................................................................................................................................................................ 28467-92-7 240. benzaldehyde, 4-propyl-.

................................................................................................................................................................................................................... 28785-06-0 241. Indole-3-carboxaldehyde. 1,2-diphenyl-.

......................................................................................................................................................................................... 29329-99-5 242. 3-cyclohexene-l-acetaldehyde, a, 4-dim ethyl-.

............................................................................................................................................................................. 29548-14-9 243. 2,4- ctadienal, (E,E)-.

..................................................................................................................................................................................... .................................. 30361-28-5 244. 2,4-undecadienal, (EE)-.

................................................................................................................................................................................................................... 30361-29-6 245. 4-decenal

.......................................................................................................................................................................................................................................... 30390-50-2 246. nonadienal

.......................................................................................................................................................................................................................................... 30551-17-8 247. 4,7-Methano-lH-indenecarboxalde hyde, octahydro-.

............................ :
....................................................................................................................................... 30772-79-3 248. bicyclo[3.1.1]hept-2-ene-2-acetaldehyde, 6,6-dimethyt-.

............................................................................................................................................................ 30897-75- 7 249. benzaldehyde, dichloro-.

................................................................................................................................................................................................................... 31155-09-6 250. 2-furanproplonaldehyde, P, 5-dimethyl.

.................................................................................................................................................................... ..................... 31704-80-0 251. o-Tolualdehyde, 4-[ethyl(2-hydroxy-3-phenoxypropyl)amino]-, carbanilate (ester)

.................................................................................................................. 32089-69-3 252. 3-butenal, 2-methyl-4-(2,6,6-trimethyl-l-cyclohexen-1-yl).

..................................................................................... t

.................................................................... 32791-31-4 253. 4,9-decadienal, 2,5,9-trim ethyl

......................................................................................................................................................................................................... 32803-39-7 254. 1H, 5H-benzo[ij]qulnolizine-9-carboxaldehyde, 2,3,6,7-tetrahydro-.

........................................................................................................................................... 33985-71-6 255. benzeneacetaldehyde, a-methyl-4-(1-methylethyl)-.

..................................................................................................................................................................... 34291-99- 1 256. 6-octenal, 3-ethenyl-3,7-dim ethyl-

................................................................................................................................................................................................... 34687-42-8 257. 6-octenal, 3-ethyl-3,7-dim ethyl-.

....................................................................................................................................................................................................... 34687-43-9 258. 2-heptenal, 2-propyl.

.......................................................................................................................................................................................................................... 34880-43-8 259. 2-hexenal, 5-methyl-2-(1-methylethyl)-.

.......................................................................................................................................................................................... 35158-25-9 260. 11-Tetradecenal, (2)-.

......................................................................................................................................................................................................................... 35237-64-0 261. benzaldehyde, 3-(1,1,2,2-tetrafluoroethoxy)-.

.............. :
................................................................................................................................................................. 35295-35-3 262. benzaldehyde, 4-(1,1.2,2-tetrafluoroethoxy)-.

................................................................................................................................................................................ 35295-36-4 263. benzaldehyde, 4-[bis[2-(benzoytoxy)ethyl amino]-2,5-dim ethoxy-.

........................................................................................................................................... 35473-23-5 264. 11-tetradecenal, (E)

.......................................................................................................................................................................................................................... 35746-21-5 265. blcyclo[2.2.2]oct-5-ene-2-carboxaldehyde, 1-methyl-4-(1-methylethyl)-, (1a,2a,4B)-

............................................................................................................. 36208-33-0 266. btcyclo[2.2.2]oct-5-ene-2.carboxaldehyde, 4-methyl-l-(1-methylethyl)-, (1a,2a,4l)-

............................................................................................................. 36208-34-1 267. bicyclo[2.2.2]oct-5-ene-2-carboxaldehyde, 1-methyl-4-(1-methylethyl)-, (la,23,4 )-

.............................................................................................................. 36208-35-2 268. bicyclo[2.2.2]oct-5-ene-2-carboxaldehyde, 4-methyi-l-(1-methylethyl)-, (la,2fl,4,)-

....................................................................................................... 36208-59-0 269. 2-thiophenecarboxaldehyde, 5-ethyl-

.............................................................................................................................................................................................. 36880-33-8 270. dodecanal, 2-methyl-.

........................................................................................................................................................................................................................ 37596-36-4 271. 3-cyclohexene-l-carboxaldehyde, 4-[2-(3,3-dim ethyloxiranyl)ethyl]-.

........................................................................................................................................ 37677-09- 1 272. 3-cyclohexene-l-carboxaldehyde, 3-[2-(3,3-dim ethyloxiranyl)ethyl]-.

........................................................................................................................................ 37677-10-4 273. 2-propenal, 3-bicyclo[2.2.1 hept-5-en-2-yl-2-m ethyl-.

.................................................................................................................................................................. 38284-42-3 274. 3-cyclohexene-l-carboxa ldehyde, 2,4-dimethyl-6-propyl-.

........................................................................................................................................................... 39067-36-2 275. bicyclo[2.2.1]hept-5-ene-2.carboxaldehyde, 3-propyl-.

............................................................................................................................................................... 3908 7-39-5 276. 8-nonenal

........................................................................................................................................................................................................................................... 39770-04-2 277. 9-decenal

........................................................................................................................................................................................................................................... 39770-05- 3 276. propanal, 3-hydroxy-2-(hydroxym ethyl)

........................................................................................................................................................................................... 40364-80-5 279. 2,6-nonadienal, 3,7-dim ethyl-

........................................................................................................................................................................................................... 41448-29-7 280. acetaldehyde. [(3,7-dimethyloctyl)oxy]-.

........................................................................................................................................................................................ 41767-05-9 281. acetaldehyde, (2-phenylethoxy)-.

.................................................................................................................................................................................................... 41847-88-5 282. 3-cyclohexene-l-carboxaldehyde, 4,5-dimethyl-2-(2-methyl-lopropenyl)-, (1a,28,5.)-.

........................................................................................................... 42507-55-1 283. 3-cyclohexene-l-carboxaldehyde, 4,5-dimethyl-2-(2omethyl--propeny)-, (1a,2,6,5a)-.

........................................................................................................... 42507-56-2 284. 3-cyclohexene-l-carboxaldehyde, 4,5-dimethyl-2-(2-methyl-l-propenyl)-, (1a,2a,5,6).

........................................................................................................... 42507-57-3 285. 3-cyclohexene-l-carboxaldehyde, 4,5-dimethyl-2-(2-methyl-l-propenyl)-, (1a,2a,5a)-.

........................................................................................................... 42507-58-4 286. benzaidehyde, 4-[bis(4-methylphenyl)amino]-.

............................................................................................................................................................................. 42906-19-4 287. 2-octenal, 2-methyl-, (E)-.

................................................................................. 49576-57-0 288. benzaldehyde, 4-octyl-

...................................................................................................................................................................................................................... 49763-66-8 289. benzaldehyde, 4-hexyl-.

..................................................................................................................................................................................................................... 49763-69- 1 290. benzaldehyde, 4-(1-oxopropoxy)-.

................................................................................................................................................................................................... 50262-48-1 291. pentanal, 5,5-dimethoxy-.

.................................................................................................................................................................................................................. 50789-30-5 292. 3-cyclohexene- -carboxaldehyde, 3-(4-hydroxy.-4-m ethylpentyl)-.

.............................................................................................................................................. 51414-25-6 293. 5-heptenal, 2.2,6-trm ethyl-.

............................................................................................................................................................................................................. 52279-00-2

### Federal Register / Vol. 56, Ne. 44 / Wednesday,, March 6, 1991 / Notices

Chemical Name 

### 9545

CAS No.

294. 3-cyolohemene-1-oe oxldehyde, 1-m thyl-3-(4-methyl-3-pentenyl)-.

........................................................................................................... .............. 524744-60-9 295. 3-cyloheme-1-oerbo ndehyde, 3-(4-methyl-3-pnteny)

......................................................................................................................................... 2...5....... 5 47-89-5 296. bern ldehyde,3(hloemethyl-4-methoxy-

........................................................................................................................................................................... 52577-09-0 297. cyclehexeseoeb e~ hyde, 2,6,6-trimethy l

.................................................................................... .......................... ......... ............... .. 62844-21-D 29. 2-prpenl, 2m o-3-metoy

........................................... .............................................................................................................................................. 52955-4-6 29. aoetuldehye. (ootyly-

......................................................................................................................................................................................................... 5348-14-5 300. 0-W deoeeI. ().)-

................................................................................................................................................................................................... S3939--274 301. 114 xadeoen , (2)-

........................................................................................................................................................................................ ...................... 53939-24- 302. bemfdkyde, *OyI

.............................................. ............................................................................................................................................................ 53951-50-1 309. S."5 ,-deoede

, 2,6,10-4-methyl-

................................................................................... . ........................................................................ ....... 54082-68-7 304. 3-cyoloheuee-1-oebomWldehyde, 5.(3-hydmoy3-methyibutd)-3-mthyi-.

......................................................................................................................... 54221-01-1 305. 2,44tradeoedie

.............................................................................................................................................................................................................. 54306-035

06. cylohexefecerbekolehyde, (4-methyl-3-penteny)-

.............................................................................................................................................................. 54323-26-1 307. 6-otenal, 7-methyl*3-m thyle

. ................................................................................................................................................................................................ 55050-40--3 306. acetdehyd 1-ethyl-i dro3,3-dimethyl.5-phenylsulfonyl).2Hindol-2ylidene-

........................................................................................................ S5203-66-2 309. 36-ectadm , 3,7-dimethyl-

.................................................................................................................................................................................................... 55722-59-3 310. 4hemnal, 2-etheyl-2,S4methyl-.........................................................................................................................................................................................-.. 56134-05-5 311. S4,wewdooerie, -(,Z)

.................................................................................................................................................................................................................... 56219-04" 312. 2.4,nOe

...................................................................................................................................................................................................................... 56260-22- 314. 2,4-etad l, (EE-

.................................................................................................................................................................................... ........... 56767-18-1 314. 7-howdeoW, (7)-

................................................. ................... ....... ............................. .......... ................ ...... .... ..... ........ ..... ............................................. .... 56797-40--1 315. 4-I ezoe be~x d de, 205odihydr-2-m thy-5oxo.3-phenyl.

............................................................................................................................ 5 879-25-2 316. benzwen e*aoe ldey , a 2/-lanylmethylene)-

................................................................................... .......................................... ......... 5756660-2 317. 4-hexenal, S-met

.......................................................................................................................... ....... 58191-81-4 318. 2-nphthlenecasboxaidhyde, 3-ethyl-5,68,7,8-tetrahydro.5,5,8,8-tetramethyl-.......................................................................................................... 58243-85-9 319. 6-gndecenal

....................................................................................................................................................................................................................... 58296 1-4 320. beozaldehyde, 2AoG4;4 w -................................................................................................................................................................................ 6...... 58470-10-3 321. 2,6.decad*W , 3,, trkmthy-.

................................ .. . ..... ....... .... ......... ...................................... .................................................................................... ...... 58605-97-3 322. 7- enal, 4,-dmthy-

................ 3.u...................

.. ..................... ...................................................................... 5.7........8.

. 587724M-1
323. 2,3b-methano-Sbflcycgenta 1,3 cyclopropa 1,2 bonzene-4-carboxaldehyde, octahydro-77,8,8-tetramethyl-

............................................... ............. 59056-66-6
324. popanal.2bomo-3,3dimethoxy-

........ .... .................................................................................................... 59453-00-6 325. 4,7.metha'lo-N-ndene-6.caboxadehyde, 2a,4,5,6,7,7a-hexahydro-, (3aa,4axa,7 a. 7aa)-.

. ........... . .......................................... 6...9

...... 5 I-22-4 326. 4,7-metlhao-IH-ndene-5 arboxaldehyde, 3n,4.5.6,7,7a-hexahydro, (a,4a.7,7a.)-

............................ 5961-20-5 327. 2-p tenal, -meth 2 ( t thio) y -

. .. ................................... .. 59902-01-1 328. 2,41-dadecatLeai. 2,6-dimethyl-10-methylene-

............ ......... ......................................................................... 60066-88- 329. 2,4 -deca a, 2,5,9-timethyl-

........ .... ........ ..... ............. .................................................................... 60437-19-6 330. 0-exadecen.al , 14.methyl-, (4)-.

........... . ... . .................. .............................................................................................. 60609-56-2 331. 2-nerenal, (-

.............. ...................... ...... .................................................................................................... 60784-31-4 332. 2,4N4decadienal

.... ................................... ....................................................................................................................................... 60996-24-6 333. 4-hexenal, 5-methyl.2(1-methylethylidene)-, dihydro der.t.

..... .............................................................................................................................. 61792-5-8 334. 2H.2,4a-methanonaphthalene-8.carboxaldehyde, 1.3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S)

................................................................................... 61826-54-4 335. heptanal, 6 .melhoxy,2 ymet l

......... ... .. m...........................t.......................................................................................................................... 6243941-2 336. IN, SH-bwEzo oijlquinilzine.9.carboxadehyde, 2,3,6,7-t9Irahydro-6-hydroxy-

... ............................................................. 63149-33-7 337. benzaldehyde, 2-htdroxy.5-nonyl-.

........................... ................................. . .................. ............... .63....1..................0.................. 6375 -4 338. 2-4bad OenaL.

............... ....................... ............................................................................................... 64461-99-0 39. dec al, 2 thyldene-

.... . ... ........ ............ . ..................................... 64625-20-3 40. benddehyde, 4-0222.(benzoyloxy)ethynjamino-

................................. . .... 65072-25-5 341. 2-propena, 3,(4-methoyphey)-2-methyl-.

. . .. .. ........................................................................................................................ 65405-67-6 342. 4-decenal, (E)-

..... .................... ...... ............................................................................................................................... 65405-70-1 343. a taldehyde, (3,7.dimethyl-2,8-octadienyl)oxy.-, (E)-

. ............................................................................................................................................... 65405-73-4 44. colohexenb ana, a,2e-tramethyl-

...................... . ................................................................................................................................ 65405-84-7 945. 2oy1ohexene-lca ehyde, 4-(4-methyl-3-penteny)-l-(2-propenyl)-.

............................. 6.........7....................................................................................... 66310-72- 6. tumnepopanal, 4-cyclopentyl-a-methyl-.

............................................................................................. . . . . . . . . . 6867-37-6 347. 3,oclohmo e -1-cato aidehyd
, 3.5,6-trimethyl-.

..... ............................................................................ . . . .... . 67634-07-6 34. tlcolo[2.2i2octane2-carboxaldehyde, 6-(1-methylethyl)-.

....................................................................................................................................... 67662-97- 34I. 3-ycqlotxene-1-catoxaldehyde, 1-methyl-4-(4-methy-4-pentet)-.

........................................................................................................................ 67746-28-4 350. b ret, 2ohydrow-3-methyl-

............................ ...................................... ................................................................................................................ 67755-97-9 351. 2popenWl, 3-(2,2-dimethy-6-methylenacyclohexyl)-2-nethyl-

..................................................................................................................... 0................. 67801-1-2 352. 2,pmpenal. 2-melhyl-3-(2,6,6-trimethyl-2-cyclohexeno1-yi)

........ ............................................................................................................................... $7801-14-3 352. c*na, 2-(2fu)

. ..... . .... .............. .... . ...................................... . .......... 67801-17-6 354. 24 hthaIneacatadehyde. 567,88-tetrahydro-

.............................................................................................................................................................. 67801-18-7 35S. Utie nal, 2-(2-xranylmnethylene)-

... ....... .. ........................................................................................................................................... 67601-21-2 356. 3 doht xene-l-ca oxaldehyde, 3,6-dimethyl-. ...........................................................................-.................................... ..... ...... 67801-654 357. bmmldehyde, 24,5-triethoxy................................................................................................................................................................................................... 67827-54-7 35B. biclo[22.2]oct-5-ene-2-caboxadehyde, 6-methyl-8-(1-methylethy)-.

................................................................................................................................... 67845-30-1 350. soetaldehyde, (4-methylphenoxy).

............................................................................................................................................................................................. 67845-46-9 360. acetaldehyde, 14-(1, 1-dimethylethyl)-2-methylphenoxy]-.

....................................... 7................................................................................................................... 67846-53" 3'.

- ioyclo[2.2.2oct-5-ene-2-carboxaldehyde, 1-methyl-4-(1-methylethyl)

............................................................................................................................... 67890-79-3 W2. bicvlo[2.2.2oct-5.ene-2-carboxaldehyde, 4-methyl-l-(1-methylethyl)..7................................................................................................................................... 67920-94-9 363. 2-Vclohaxne--car oxaldehyde, 6-[,(-methyethyl)-2-propeny-

............................................... ............................. . . . . . . . . . 67052-55-0 264. popanal, 2-mOh¥2-Imethyldithio).

....................................................................................................................................................................................... 67952-60-7 305. 3-cyclohexene-l-carboxaldehyde, 3, 5-dimethy-

........................................................................................................................................................................ 68036-48-6 366. 2-ylohemxee1-caxboxaldehyde, 2, 4-dimethyl-............................................................................................................-......... 680394984 367. ha nal, 3.3.5-trifethy-

............................................................................................................................................................................................................ 68039-71-4 36. beweneacetaldehyde, 4-athy

............................................................................................................................................................. ................ 68083-54-6 SM. bmweneacetaldehyde, 2, 4-dimethyl-.

........................................................................................................................................................................................... 68083-55-6 370. 

### 3-Sedecenal

.................................................................................................................................................................................................................................. 68083-57-4 374. petnal, 3-ethoxy-4-methyl-.

................................................................................................................................................................................... ; ....................... 68084-08-2 372. oydohexenecarboxadehyde, dimethyl-.

........................................................................................................................................................................................ 68064-52- 373. aoetaldehyde. (3-hexenytoxy)-. (2).

.......................................................................................................................................................................................... 68133-72-2 374. 3-cyclohexene-l-c~aoxadehyde, 3,5-dimethyl--propyl-.

.................................................................................... ....................... 68140-4-5 375. 3-cVclohexene-1-carboxaldehyde, 2,4, 6-tmethyl-l-(2-propenyt)-.

......................................................................................................................................... 68140-56-

### 9548 Federal Ikegister ] VoL 56, No. 44 -/ Wednegday, March 6,'1991



## . Notices

Chemical Name CAS No.

376. 3-cyclohexene-l-carbo xaldehyde, 1-methyl-2-(1-m ethyletheny!).

......................... .................................................................................................................... 68140-59"-
377. 3,4-octadienal, 2-butyl-2-ethyl-5,7-dimethy-

................................................................................................................................................................................. 68140-60-3 378. nonanal, 5-ethyl-2-m ethyt-

................................................................................................................................................................................................................ 68141-14-0 379. 3-dodecenal, (2).

................................................................................................................................................................................................................................ 68141-15-1
380. acetaldehyde, (3,7-dim ethyl-2,6-octadienyl)oxy]-

.................................................... ................................................................................................................... 68213-87-6
381. benzeneacetaldehyde, ar, a-diethyl-

............................................................................................................................................................................................... 68228-11-5
382. btyc lo[2.2.2]oct-5-ene-2-carbo xaldehyde, 5(or 6)-methyl-7(or 8)-(l-m ethylethyt)-6.

................................................................................................................ 68259-31-4
383 bicyclo(2.2.2]oct-5-ene-2-carboxaldehyde, 3,5(or 3,6)-dimethyl-7(or 8)-(1-methylethyl)-

....................................................................................................... 68259-32-5
384. hexanal, 2,3,5,5-tetramethyl-.

.......................................................................................................................................................................................................... 68391-29-7 385 acetaldehyde, (4-methoxyphenoxy)-.

.............................................................................................................................................................................................. 68426-09-5 386 benzaldehyde, 2,4-bis( l-m ethylethyl)-.

........................................................................................................................................................................................... 68459-05-0 387. butanal, 3-(heptyloxy)-2-oxo-

............................................................................................................................................................................................................ 68 555- 32-8
388. 2-butenal, 2-methyl.4-(2,6,6-trim ethyl-2-cyclohexen- -y).

........................................................................................................................................................... 68555-62-4 389. 3-cyclohexene-l-a rboxaldehyde, dimethyl-.

.................................................................................................................................................................................. 68737-61-1

390. 2-naphthalenecarboxaldehyde, octahydro-8,8-dimethyl-.

............................................................................................................................................................. 68738-94-3
391. 2-naphthalenecarboxaldehyde, octahydro-5,5-dim ethyl-.

............................................................................................................................................................. 68738-96-5 392. acetaldehyde, 2,6-bis(1,1-dim ethylethyl)-4-m ethytphenoxy]-.

...................................................................................................................................................... 68797-73-9 393. benzeneacetaldehyde, 3,4-dimethyl-.

............................................................................................................................................................................................. 68844-97-3 394. 4,9-decadlenal, 5,9-dimethyl8.

........................................................................................................................................................................................................... 68844-98-4 395. 3-cyclohexene-l-carboxaldehyde, 4-(4-hydroxy-3,4-dim ethylpentyl)-

......................................................................................................................................... 68891-88-3 396. acetaldehyde, (2-furanythio)-.

........................................................................................................................................................................................................ 68922-05-4
397. 2-naphthalenecarboxaldehyde, 1,2,3,4,5,6,7,8-octahydro-5,5-dim ethy-.

................................................................................................................................... 68991-96-8
398. 2-naphthalenecarbo xaldehyde, 1,2,3,4,5,6,7,8-octahyd ro-8,8-dimethyl-.

................................................................................................................................... 68991-97-9 399. 2-furanarboxaldehyde, tetrahydro-5-oxo-, (R7)-.

............................................................................................................................................................................ 70606-00,-7

400. 4,9-decadienal, 4,8-dimethyl-.

.......................................................................................................................................................................................................... 71077-31-1
401. 11,13-hexadeadlenal, (Z,Z)-

........................................................................................................................................................................................................ 71317-73-2 402. dodeanal, 11(or 12 -m ethyl

...................................................................................................... .......... .......................................................................................... 71566-52-4 403. benzaldehyde, 4-[(2,3-dihydroxypropyl)ethylam ino]-2-methy-, sulfate (1:1) (salt)

................................................................................................................... 71673-10-4
404. 1,5-cyclododecadienecarboxaldehyde. trimethyl-

.................................................................................................................................................................. . 71735-87-0 405. 3-cyclohexene-l-carboxaldehyde, 1,2,4(or 1,3,5)-trimethyl-

. ...................................................................................................................................................... 71832-78-5
406. acetaldehyde, (2,6-dimethylphenoxy)-.

........................................................................................................................................................................................... 72102-89-7
407. benzaldehyde, 4-(acetyloxy)-3-ethoxy-.

.......................................................................................................................................................................................... 72207-94-4
408. 2-hexenal, 4(or 6)-methyl-2-propyl-.

................................................................................................................................................................................................ 72208-09-4 409. heptanal, 3,5,5-trimethyl

................................................................................................................................................................................................................... 72333-11-0 410. 5-octenal, 2,6-dimethyl-.

.................................................................................................................................................................................................................. 72845-35-3
411. cinnamaldehyde, still bottoms
........................................................................................................................................................................................................ 72869-33--1 412. acetaldehyde, (decyloxy)

................................................................................................................................................................................................................ 72894-07-6 413. 10-undecenal, 2-ethylidene-

............................................................................................................................................................................................................. 72894-14-5 414. 2,12-tridecadienal

.............................................................................................................................................................................................................................. 72894-15-6 415. benzeneacetaldehyde, 3.methyl.

.................................................................................................................................................................................................... 72927-80-1 416. acetaldehyde, [(3a,4,5,6,7,7a-hexahydro-4,7-methano- H-nden-6-yl)oxy].

............................................................................................................................. 72927-85-6 417. 3-cyclohexene-l-carboxaldehyde, 5.(2.hydroxy-2.rnethylpropylidene)-.

..................................................................................................................................... 72927-97-0 418. 4,9-decadienal, 2,4,8-timethyl-.

...................................................................................................................................................................................................... 72928-00-8 419. acetaldehyde, C(3a,4,5,6,7.7a-hexahydro-4,7-methano-lH- enden-5-yl)oxy]-.

............................................................................................................................ 72928-15-5 420. 2-cyclohexene-l-acetaldehyde, a, m 2-dimethyl-5-(l-m ethylethenyl)-.

.......................................................................................................................................... 72928-28-0 421. undecanal, 2-methyl-2-(2-propenyl)-.

.............................................................................................................................................................................................. 72928-37-1 422. acetaldehyde, [4-(1,1-dimethylethyl)phenoxy]-.

............................................................................................................................................................................ 7 2928-50-8 423. 3-cyclohexene-l-carboxaldehyde, 2-(2-hydroxy-2-m ethylpropylidene)-.

..................................................................................................................................... 72939-53- 424. 2-cyclohexene-l-acetaldehyde , 2-methyl-5-(l-methylethenyl)-.

.................................................................................................................................................. 72983-68-7 425. 2-butenal, 2,3-dimethyl-4-(2,6,6-timethyl-2-cyclohexen-1-yl)-.

.................................................................................................................................................... 73507-49-0 426. 3-butenal, 2,3-dim ethyl-4-(2,6,6-trimethyl-l-cyclohexen-l.yl).

.................................................................................................................................................... 73507-50-3 427. 4,7-methano- H-indene-2-carboxaldehyde, octahydro-5-methoxy-8.

........................................................................................................................................... 86803-90-9 428. 1H-indenecarboxaldehyde, 2,3,3a,4,5,6- hexahydro-l,3,3-trimethyl-.

............................................... .......................................................................................... 94406-15-2 429. biphenyl, polybromo
......................................................................................................................................................................................................................... No CAS No. 430. bromophenol (brl-br2. br5)

.............................................................................................................................................................................................................. No CAS No. 431. carbamate, bis(dibromopropyl).

...................................................................................................................................................................................................... No CAS No. 432. phosphite, bis(2,3-dibromopropyl)-.

................................................................................................................................................................................................. No CAS No. 433. biphenyl, polybromo- (br8-brlO)

...................................................................................................................................................................................................... No CAS No. 434. phosphite

............................................................................................................................................................................................................................................ No CAS No. 435. toluene, tetrabromochloro-

............................................................................................................................................................................................................... No CAS No. 436. brom nated terphenyls

...................................................................................................................................................................................................... ............... No CAS No. 437. carbam ate, dibromopropyl-.

.............................................................................................................................................................................................................. No CAS No. 438. phosphite, allyl bis(2,3-dibromopropyl)-.

...................................................................................................................................................................... ................... No CAS No.

439. phosphoryl chloride, bis(dibromop opyl)-.

...................................................................................................................................................................................... No CAS No. 440. 1-propanol, 2,3-dibromo-, phosphate (3:1)

.................................................................................................................................................................................... 126- 72-7 441. phenol, pentabrom o
......................................................................................................................................................................................................................... 608-71-9 442. brominatedterphenyls

...................................................................................................................................................................................................................... 623-27-8 443. brom nated terphenyls

..................................................................................................................................................................................................................... 626-19-7 444. oxetane, 3,3-bis(bromomethyl)-.

...................................................................................................................................................................................................... 2402-83-7 445. oxirane, bromoethyl

........................................................ ................................................................................................................................................................. 3132-64-7 446. brom inated terphenyls

...................................................................................................................................................................................................................... 3365-02-4 447. brom inated terphenyls

...................................................................................................................................................................................................................... 3365--03-5 448. benzene. pentabromo(2-propenyloxy)-.

.......................................................................................................................................................................................... 3555-11-1 449. brominated terphenyls

...................................................................................................................................................................................................................... 4266-99-3 450. brom inated terphenyls

...................................................................................................................................................................................................................... 4456-49-9 451. phenol, 2,6-dibromo-4-[1-(3-brom o-4-hydroxypheny)-l-m ethylethyl]-.

...................................................................................................................................... 6386-73-8 452. 1,2-benzenedicarboxytic acid, bis(2,3-dibromopropyl) ester

...................................................................................................................................................... . 7415-86-3 453. brominated terphenyls

................................................................................................................................................................................................................ 10273-74-2 454. phosphonium
, 1,2-ethanediylbis[tris(2-cyanoethyl)]-, dibrom ide

................................................................................................................................................ 10310-38-0 455. oxirane, (2.bromoethyl)-.

.................... ............................................................................................................................................................................................. 13287-42-8 456. 1,1'-biphenyl, 2.2,3,3',4,4',5,5',6,6'.-decabrom o-........................................................................................................................................................................... 13654-09- 457. 1,2-benzenedicarboxylic acid. 3,4,5,6-tetrabromo-, aluminum salt (3:2)

.................................................................................................................................... 13654-74-5

### Federal Register ./ 

### VoL 56, No., 44,

## / Wednesday, March 6, 1991 / Notices 9547

Chemical Name CAS No.

458. fumai dc aid,bis(pentabromophenyl) ester .................................................................................................................................................................................... 15108-51-7 459. 4,7-methano-IH-ndene, 1,2-dibromo-4,5,6,7,8,8-hexachloro-2,3,3a,4,7,7a-hexahydro-.

......................................................................................................... 18300-044 460. 1,2-benzenedicarboxyl dic acid,3,4,5,6-tetrabromo-, dipotass tum salt
......................................................................................................................................... 18824-74-3 461. brominated terphenyls

...................................................................................................................................................................................................................... 19799-37-2 462. brorninated terphenyts

....................................................... ............................................................................................................................................................ 20653-70-7 463 ethanol, 2-(2,4,6-tibromophenoxy)-

................................................................................................................................. ........................................................... 23976-66-1 464. fumaric acid, bis(2,4,6-tribromophenyl) ester
.............................................................................................................................................................. .................. 24138-34-9 465. phenol, tribromo-............................................................................................................................................................................................................................... 25376-38-9 468. ethene,dibromo ............................................................................................................................................................................................................................. 25429-23-6 467. poly[oxy(2,6-dibromo-1,4-phenylene)J]

.......................................................................................................................................................................................... 26023-27-8 468. benzene, tribromo(2-propenyloxy)-.

.............................................................................................................................................................................................. 26762-91-4 469. 1,1'-biphenyl, nonabromo.............................................................................................................................................................................................................. 27753-52-2 470. 1,1'-biphenyl, ar, at, at, ar, a r', at',

a r, ar -octabrom o- ............................................................................................................................................................... 27858-07-7 471. brominated terphenys ...................................................................................................................................................................................................................... 29605-98-9 472. phenlol, brom o ..................................................................................................................................................................................................................... .............. 32762-51-9
473. phenol, 4,4'-(1-meth ylethyIidene)bis 2,6-dibromo-, diacetate

...................................................................................................................................................... 33798-02-6 474. brominaeted terphenyls
................................................................................................................................................ .................................................................... 36719-77-4 475. toluene, 2-chloro, tetrabrom o-........................................................................................................................................................................................................ 39569-21-6 476. phenol, 4,4'osutfonylbis(2,6-dibrom o)-.
.......................................................................................................................................................................................... 39635-79-5 477. brominated terphenyls

..................................................................................................................................................................................................................... 40817-03- 478. phenol, dibrom o-, phosphate (3:1)
................................................................................................................................................................................................. 49690-63-3 479. brominated terphenyls
..................................................................................................................................................................................................................... 51211-09-7 480. 1-propanol. 2,3-dibromo, carbamate ............................................................................................................................................................................................. 55190-46-0 481. brominated terphenyls

.................................................................................................................................................................................................................... 57313-42-5 482. bromlnated terphenyls

................................................................................................................................................................................................................. 57313-44-7 483

. brominated terphenyls
...................................................................................................................................................................................................................... 57313-47-0 484. phenol, 2,3,4,6-tetrabromo-5-methyl-

...................... ......................... ............................................................................................................................................ 58169-994 485. ethanol, 2-(pentatxomophenoxy)
.................................................................................................................................................................................... ............. 60593-0 2-4 486, carbamic acid, bis(2.3-dibromopropyl)-, ethyl ester
................................................................................................................................................................... 60728-46-3 487. 2,4,8,10-tetraoxa-3,9-diphaspiro[5.5]undecane, 3,9-bis[3-romo-2,2-bls(bromomethyl)propoxy]-, 3,9-dioxide

.................................................................. 61090-89-9 488. brominated terphenyls

..................................................................................................................................................................................................................... 65449-00-5 489. phosphoric acid, 2,2-bis(bromomethyl)-3-chloropropyI bis[2-chloro-l-(chloromethyl)ethylJ ester

......................................................................................... 66108-37-0 490. benzene, dibromo(2-propenyloxy)-

.................................................... ............................................................................................................................................. . 66741-65-9 491. diphenoxyethane,decabrom o ................................................................................................................................................................................................... 68797-39-5 492. phenol, 2,4,6-tibromo-, carbonate (2:1)
......................................................................................................................................................................................... 67990-32-3 493. phenol, pentabromo., aluminum salt
.............................................................................................................................................................................................. 68 084-29-7 494. 1,2-benzenedicarboxylic acid, 3,4,5,6-tetrabromo-, m agnesium salt (1:1)
................................................................................................................................ 68084-3 1-1 495. 2-Sutenedioic acid (Z)-, bis(pentabromophenyl) ester

.............................................................................................................................................................. 68091-86-1 496. benzene,pentabromo[2-(tetrabrom ophenoxy)ethoxy]-.

............................................................................................................................................................ 68299-26-3 497. benzene, pentabromo[2-(tetrabromochlorophenoxy)ethoxyl-.

................................................................................................................................................ 68299-27-4 498. benzene, 1,3,5-tribromo-2-(2-bromoethoxy)-

................................................................................................................................................................................ 68413-71-8 499. benzene. brominated chlorinated

................................................................................................................................................................................................ 68583-99-3 500. hexanedioic acid, bis[3-bromo-2-(bromomethy -2-(hydroxymethy)propyl] ester

.................................................................................................................... 70776-34-0 501. bromina ted terphenyls
...................................................................................................................................................................................................................... 73206-29-8 502. brom lnated terphenyla

...................................................................................................................................................................................................................... 73206-30-1 503. brom inated terphenyts

...................................................................................................................................................................................................................... 73206-31-2 504. brominated terphenyls

................................................... ...................... 73206-32-3 505. bromlnated terphenyts
..................................................................................................................................................................................................................... 73206-33-4 506. brominated terpheny s .................................................................................................................................................................................................................... 73216-03-2 507. brom inated terphenyls
.................................................................................................................................................................................................................... 75594-47-7 508. brominated terphenyls
...................................................................................................................................................................................................................... 89961-07-9 509. brom nated terphenyls
................................... ................................................................................................................................................................................... 89961-08-0 510. brom inated terphenys ...................................................................................................................................................................................................................... 89961-09-1 511. brom lnated terphenyls
..................................................................................................................................................................................................................... 89961-10-4 512. brominated terphenyls
...................................................................................................................................................................................................................... 89961-11-5 513. brominated terphenyls

...................................................................................................................................................................................................................... 89961-12-6 514. bromnated terphenlsyls

..................................................................................................................................................................................................................... 89961-13-7 515. brominated terphenyls

...................................................................................................................................................................................................................... 95918-83-5 516. brom inated terphenyls
.................................................................................................................................................................................................................... 95918-85-7 517. brom inated terpheny$

...................................................................................................................................................................................................................... 95919-18-9 518. brominated terphenyts

...................................................................................................................................................................................................................... 95919- 20-3 519. bromina ted terphenyls
...................................................................................................................................................................................................................... 95919-22-5 520. brom lnated terphenyls
.................................................................................................................................................................................................................... 95919-23-6 521. bromlnated terphenyls

............................................................................................................................................................................................ ......................... 101710-68-3 522. brominated terphenyls

..................................................................................................................................................................................................................... 108802-71-7 523. brominated terphenyts
............................................................................................................................................................................ ......................................... 122216-73-3 524. Naphthalene, 1 socyanato-
........................................................................................................................................................................................................... 86-84-0 525. benzene, 1,1'-methylenebis(4 -socyana to-3-methy)..
................................................................................................................................................................... 139-25-3 526. benzene, 1-isocyanato-3-methyl-.

.................................................................................................................................................................................................... 621-29-4 527. benzene, 1-isocyanato-2-methoxy-.

................................................................................................................................... ........ 700-87-8 528. sulfuryl chloride Isocyanate............................................................................................................................................................................................................. 1189-71-5 529. propane, 2-socyanato-2-methyl-

.. . ... ........................................................................................................................................................ 1609-86- 5 530. propane, 2-socyanato

.................................................................................................................................................................................................................. 1795-48-8 531. diazene, (44socyanatophnyl)phenyl-.
....................................................................................................................................................................................... 1942-61-6 532. ethane, 1-chloro-2-lsocyanato-

....................................................................................................................................................................................................... 1943-83-5 533. hexadecane. 1-1socyanato-

....................................................................................................................................................................................................... 1943-84-6 534. hexane, 1-isocyanato

.......................................................................................................................................... ..................................................................... 2525-62-4 535. benzene, 1,1 -methylenebis(2-isocyanato)-

.................................... .................................................................................................................................... 2536-05-2 536. cyclohexane,1,4-diisocyanato-

............................................................................................................................................................................................. 2556-38-7 537. ber onltrile, 44sothlocyanato-

.................................................................................................................................................................................................... 2719-32-6 538. acetyl Isocyanate, trichioro-

..................................................................................................................................................................................................... 3019-71-4 539. octane, 14socyanato-.

....................................................................................................................................................................................................................... 3158-26-'

### 9548 Federal 'Register /, Vol. 56, No. 44 / Wednesday, March 6,1991 / Notices

Chemical Name CAS No.

540. N aphthalene, 1,5-dlsocyaneto-

....................................................................................................................................................................... ................ 3173-72-6 541. benzene,1-c loro-2-socyanato
............................................................... ...................................................................................................................... 3320-e3-0 542. benzene, 1 ocyanato-2-n o-..................................................... ........................................................................................................................... 3320-86-3 543. benzene, 1- cyenato-3-r

.. ro- ............................................................................................................... ... . . . . . ... .. 3320-87-4 544. benzene, 1,3-bs(ycy-natomet )

..... ................................................................................................... ..... ... 3634-83-1 545. benzene. I,I'-oxbi4.4eocyanlo)-

............................................................ . . ... ............ ................ 4t28-78 546. dodecane, 1-aocyanato-

....................................... ................................................................................................ 

### 2............... 4202-36-4 547. benzene, 1,4-dichloro-2-socyanato-

........................................... .................................................................................................................................... 5392-82-5 548. benze -etho y-2 ocy ne .to-
................................................. ......................................................................................... ........................................... 5395-71-1 549. bemene, 1.-es cyanato-4-methoxy-

....................................................................................................................................................................................... 5416-93-3 550. ehe an e ,4 ocyan a e y t.

............................................................................................................................................. 7046- -9 55t. cyct ohexane, i,4-bia(kKo anatomethy
............................................................................................................................................................................... 10347.- 4-3 552. fom m arnice A ethenyt-.

........ ...

................. ....... .... . ................................................................................. ................................ ................. .................... ............ 13162-05-5 563. benzene, 4-ocyan to- -methyl-2-nito-

....................................................................................................................................................................................... 13471-69-7 554. a ne, P 4 anat opyi #methoxy-

. ............................................................................................................................................................................... 15396-00-6 555. socyankc acid, 12,356-tetracN ph enylene)dlmethyle ester

....................................................................................................................... ........ 6325-38-5 556. acetc acid,ieocyanao
, but ester ......................................................................................................................................................................... .............. _... 7046-2 -9 557. mine, chko ($-sMw a topropyl)di et, .......................................................................................................................................................... ............ 77070-70-1 55. 1.3diazetlkine-2, 4- ne, $.3-[4-[(44soyanoetophenyl)methy)-phen

- ......................................................................................................................... 17589-24-1 559. benzene ulor ac 4-sothk ayan to-, sodium salt

..................................................................................... ................................................................. 7 14- 6 560. benzene, 4soyaato -3.methoy-

............................................................................................................................................................................. 18908-07-1 56t. isocyanic acid, (2,4-dloxo-$,3- wetdedyl)bls[methylene(3,5,5-Umethyl-3,1-cyclohexylene)] ester

........................................................................... 23370-0W-5 562. mone, ethoxy(34 ocy opropyt)-

......... ............................................... . . ......................................................................................................... .. 24801-86-5 5G3. carnic acid, ocyanattomethylphenyl)-,$,2,3-ropanetriy ester .................................................................................................................................... 28470-82-8 5 4. benzene. 1-chloo.4-(socyan opheno y
.......................................................................................................................................................... .. ............ 30087-46-8 565. 1,.ldiazetldln-2-one, 1.3.bi[4-[(44soan pheiyl)methyllphenyl-4-[[4-[(4-socyanatophenyi)methyll]ptnl]imino

.............................. ......... 3107-36-5 566 benzene, thoxy4-locyanato-

............................................................................................................................................................................................ 32459-62-4 567. 1,5-naphthae sulfonic 3sothocyanato-, disodium salt
............................................................................................................................ ............. 35888-63-2 56

. cyclohexane, 1,3.b s(locyanatomethyl)

............................................................................................................................................................................. 38661-72-2 569. benzene, 2.cyanato-1,4.dimethyl-

.. .. ............. ...... .................................................................... 40397-9-0 570. beraontie, 4-socyanao.

.............................................................................................................................. . ....... 40465-45-0 571.~~~~~~~~

.......... .cd
.......... lo)- me.y eae.......

. ..... . . . . ......... .......... 410 0- 571. benzoic acd 2-(formylano)-, methy 4 .se ........ ....................... ...... ............................. ................ ...

..

................ ....... .................... :.................. 41270--8G-8 572. cyclohexane, bls(isocyanatomethyl)-

............................................................................................................................................................................ 42"170-25-2 573. benzenesunonlc acid, 5-aceyamino)-2-[2-(44sothioa to.2.sulfophenyl)etheny]-, disodium salt

................................................................................ 51023-76-8 574. 2-openo acid, 2-[[[(3locyanaowmethylpheny)agocarbony]oxy]ethyl ester ......................................................................................................... 54554-30-1 575, carbamc acid, (3-isocyanawmethylpheny)-,2-ethylhexye ester ...................................................................................................................................... 54634-94-5 576. urea, NV-bi[(5-.o an mto- I3-Uoheyc1 o )methyl-.............................................................................................

..................................... 55525-64-7 577. cabetlc acid. (3-lsocyanatomethylenyl)k, 2-ethylhexyl ester
...................................... .......... .......................................................... 5240-57-6 578. cafmic acid, (3-socwanatomethylpheny , oxyd-2,-ethanedlyl este ............................................................................................................................ 60732-52-7 579L so[isobezouran-(3, 9'73Hxanthe l- ne,3',6'-dilhydroxy-5 to nato-,hydrochlode

.... ......... ................ . 3469-13-6 5O. cafmi aci 4-( oat)methyt c, ohexyl-,axy-1,2-ethanedyl ester .................................................. .................... ............. .. 66087-21-0 581. knklodicarboni diarnkte, 2,2'-[methy aeb42- .Srp ile)lbisEtANbi aocyan.omethylphenyt)].

.... .................................... ...... 65104-99-6 582. carbemrcacd, ocyanatomethy il- methyt-1,3-propan yl eter
............ .............. .......................................................... 65105-00-2 58& carbemic acid 3isocyanatomethylphenyl)-, 1,44 tne eer ........................................................................................................ .................... 6105-02-4 584. I,3 5-triazne-2.4,(IH,3H, 5+Utione, 1,3r-tt[(5- yanato-1,3,3-methylcyclohexyl)methyl]-................................................................................. 67873-01-0 585. benenaM 0 NeN- yUbs[3- y -2,4,6-til-methylethyl)]-

........................................................................... .................................. 68083-3-6 586. cabemic acid, (3-ocya to ylphenyl), 1,2-ethanediyl eter .................................................................................................................................... 68092-73-9 57. cartamlc acid, (3-Lsoyanatomethylphervyl), oxybl$-methy2,ethanedy ester ......................................................................................................... 68092-744-0 588, carbemlc acid, ysocya lhphenyl)-, [(diethoxyphophinyl)methyliminold-2,1-ethanediy ster ...................................................................... 68133-4-2 589. heninoicr acd E2-(ethl.-2-[( 5isocyanato-(or 5)(meth n tyllaminolcar nyoxylmethyl-1,3iop.ned

................................. 68310-46-3 590. carbarnic aci, Wi-socyanaternehyliphenyl)-, I.methyt4,3-propanedOy ester ..-...... . . ................-... ............ 66844-3 50t. 1,3-dia d2,4-oa.. o. .ynl-methy.tp )e..............................

.....................................................................68655-o502. carbamic add, (5-lsocyaato2-methylpheny)-, 2-ethylhexy e t

.... e.r................................

.................... ...... . 689381-61-4 5W. carbamic acid, [(Socneto-,3 metyycyloy )meiyl., 2-ethy42-C[[[(5-isocyanato-1,3,3-trimethylcyclohexyl)methyU4

.............................. 68975-82-6 504. carbamic acid, (5-ocyato-,3,3-fm htcyclohexytmethyt)-, oxyd-2,1-ethanediy ester

. ..................... . . 68975-84-8 585. hexanoic acid, 2,-diocyanto-,2-isocyanatoethyt eate

...................... ............. .... .. ........... .. .. 69878-168 596. mecane. i,,l1-riaocyarato-

.. .. .......... ...

. .. .................................... 70198-24-2 587. urea, .-. (a.nop nyl).et.yt.phen

- -(3-..yana h lp

.. ............... ....... ............................... 7106-52-0 59. urea, -(3-iocyana1 methy~ 4yt)-N-n[4-a[[(-oW nstomethye r)amno]Arnl¢anno phenylmethtylpheny0....

............. .......... 71130-76-2 59W. carbamlc chloride,ethyl(5-lsocyano-2-methylphenyI)-

. . .......................................................................................................................... 71832-33-2 60. carbemic acid, [4-. o ana nymethyt]phnyli-, oxyd-2-ethanedyt ester

............................... ......................................................... 71832-70-7 601. carbamic acid, [(5-eocysiaato4,3,3-t e o rex tl)mnethyl]-, 2-butoxyethl ester .................................................................................................. 72152-95-6 602. bezene, 2-iwocyanao4-[( c-y-mth t methya

.. . ........................ .......................... . ..................... 75790-4-0 603. benzene, N-socyarato-2-[(4-t4yoc aolphe o .)thjo]-

......................... ................................. ........ . ....... .......... 75790-87-3 604. benzene,1.chloro-4.(penytsulonyl)

............ . ......................................................................................... ........... 80-00-2 605. benzenamlne, 2-(methylsultforl)4_-nltro-

. ... . . ...................................................- 96-74-2 606. benzene, -chr-(methylsulfony)-2-nitro-

..... .......................... ............................. .. ... ... 97-07-4 607. benzene, I-chloro-4-(methysulfonyl)-

.. ........ .......................... 98-67-7 608. 1,4-oxathlane, 4A-doxide

. . . .... .... ........ ... ............. ......... .. . .. 107-61-0 609. benzene, 1,1'-sultonytb 4-fluoo-3-niutr)--

. .......... ............. ....... ...................... ...........................................................3")2-MM610, benzene, 1,'-sufonylbsa4-fluoro)

.................................................................................................... 383-29-9 611. methane, briluomethyl)uonyil-

....... .............. ................... ........................... .... . .. 428-7"2 612. propane, 11'-sutonyb

.. ............................. ........... 698-03-8 613. butane, 1,1'-sulonylbs-

. ..- o4-9 614. benzenamlne, 3,-sutfony-bis--.-........................

. 599-61-1 615. benzene, I.1'.sutfonylbis(4-methyl)- 590-66-6 816. benzene, 1-methry-4-(phnylsultony)-

.... 640-57-3 617. tlophene, tetrahydro-3-methyt-, 1,1-dmxde

. . .. M-936 618. thiophene, 2,5-dihydo-3-methyl-, 1,7-dioxide

. . . . . . . . 1193-10" 610. berene, 1,1'-sulfonylbis(3-ntro)-

- .. . ........... ......1228-63-1 620. benzene, 1,4-dimethyl-2-[(4-methylpheyi)su*ony

- .... . 116-98-2 621. thlophene. 2f-dihydro-3-(4.methyl-3-pentenyi)-, 1,1-dioxide

_ _._._._. . ......... ........................................................-.......... 7M-32-1

### Federal Register / Vol. 56, No. 44 

## / Wednesday, March' 6, 1901 / Notices 9549

Chemical Name CAS No.

622. sulfone, 4-chloro-2-ntrophenyl methyl

.......................................................................................................................................................................................... 2163-97-5 623. methanol. [(4-methylphenyl)su fonyl]--.

........................................................................................................................................................................................ 2182-9-6 624. methane, sulfonylbis(trichloro)-

...................................................................................................................................................................................................... 3064-70.-8 625. thiophene, 3,3,4,4-tetrachlorotetrahydro-, 1,1-dioxide

.................................................................................................................................................................. 3737-4 1-5 626. benzene, 1, '-sulfonylbis(2,4-dimethy )-

......................................................................................................................................................................................... 5184-75-8 627. phenol, 2-[(4-hydroxyphenyl)sulfonyl]-.

......................................................................................................................................................................................... 5397-34-2 628. 3-thiopheanam ine, tetrahydro-, 1,1-dioxidde

...................................................................................................................................................................................... 6338--70-1 629. 1-propanamine, 2-[2-[[4-[3-(4-chloropheny)-4,5-dihydro-1H-pyrazol-1-yfl]pheny]sulfonyl]ethxy-NN-dimethy -6

........................................................... 6608-82-8 630. ethanol, 2-[(3-amino-4-methoxyphenyl)sulfonyl]-

......................................................................................................................................................................... 7425-81-2 631. 9H-thloxanthene-3,6-diamine, 10,10-dioxide

.................................................................................................................................................................................. 10215- 25- 5 632. benzene, 1,1'-sulfonylbis(2,4,6-trinitro)-1

......................................................................................................................................................................................... 10580-80-0

3-benzothiazolineethanc octyl disulfone

............... 1H-pyrazole, 3-(4-chlon phenol, 2,2'-sulfonylbisthiophene, 3,4-dibromo phenol, 2,2'-sulfonylbis benzene, 1-chloro-2-(m benzenamine, 4-(methyrnoylOl4,1- I -4-(methylsull ne xvJ

.. ...............................................................................................................................................................

, 4,b,6,/-te ranyoro-z-mno-.a..-Lp- me m ystw onyupnenyJ-. ............................................................................................................ ophenyi)-4,5-dihydro-1-[4-(methylsulfonyl)phenyl]-..................................................................................................... ; .......................... tetrahydro-, 1 [4-(1,1.3,3-te ethylsulfonyt 13244-35-4 13581-52-7 13603-70-8 14295-72-8 15038-7-2 15091-30-2 15452-894 21081-74-3 21731-56-6 643. 1,1'-iphenyl, 4,44'-bis[(4-chloropheny)suffonyl]-.

......................................................................................................................................................................... 22287-56-5 644. ethanol, 2-(4-methylphnyl)sulfonyl-.

........................................................................................................................................................................................... 22381-54-0 645. aniline, 4-(ethylsulfonyl)-2-nitro-

..................................................................................................................................................................................................... 23306-60-7 646. propionitrile, 3-N-(2-hydroxyethyl)-p-[[6-(methylsulfonyl)-2-benzothiazolyl]azolanilino-.

.................................................................................................... 24170-48-7 647. phenol, 4-(4-aminopheny)sulfonyl]-.

............................................................................................................................................................................................ 25963-47-7 648. 1,3-dithiane, 1,1,3,3-tetraoxidde

........................................................................................................................................................................................................ 26413-18-3 649. ethanol, 2-[(4-hydrazinophenyl)sulfonyl.

..................................................................................................................................................................................... 26505-12-4 650. benzene, 1,1'-suffonylbis(3.4-dimethyl)

.......................................................................................................................................................................................... 28361-43-5 651. aniline, 5-chloro-2-(methylsulfonyl)-.

................................................................................................................................................................................................ 29124-54-7 652. benznamine, 3,3'-[sulfonylbis(4,1-phenyleneoxy) ]bis-.

.................................................................................................................. .. ............................................ 30203-11-3 653. benzothiazole, 2-[(tribromomethyl)suleony

................................................................................................................................................................................ 6 31274-42-7

654. thiophene,3-(bromomethyl)-2,5-dihydro-, 1,1-dioxide

.................................................................................................................................................................. 31554-48-0 655. ethanamine, 2-[2-[[4-[3(4,5dichloro-2-methy phenyl4, 5-dihydr-1 H-pyraz-1-y ]pheny]sulfo nyeth xy-NN-dimethy

............................................ 35441-18-0 656. benzene,1,2-dichloro-4-(methylsulfonyQ).

.................................................................................................................................................................................... 38452-47-0 657. IH-pyrazol-3-amine, 4-[[4-(ethylsutfonyl)-2-nltrophenyliazo]-5-methyl-l-phenyl-

................................................................................................................... 38658-94-5 658. phenol, 4,4'-suffonylbis(2,6-dibromo)-.

.............. ............................................................................................................................................................................. 39635-79-5 659. 2-butyn-1-ol, 4-[(tetrahydro-3-thlenyl)oxy]-, S,S-dioxide

............................................................................................................................................................. 40456-28-8 660. benzene, [bis((trifluoromethyl)sulfonyljmethyl]-.

......................................................................................................................................................................... 40906-82-9 661. ethanol, 2-[(7-amino--naphthalenyl)sulfonyl-.

............................................................................................................................................................................ 43001-81-6 662. benzoxazole, 2,2'-(1,4-naphthalenediyl)bis[5-(ethylsulfonyl)-.

............................................................................................... .................................................... 43115-21-5 663. benzenamine, 4,4'-[((4-methylphenyl)suffonyl]methylene]bls(NN-dimethyl)

..................................... .4.................................................................................... 49630-05-9 664. benzenam ne, 2,2'-[sulfonylbis(4,1-phenyleneoxy)]bis-.

............................................................................................................................................................... 52338-52-0 665. ethanol, 2-[(4-methoxy-3-nitrophenyl)sulfonyl]-.

........................................................................................................................................................................... 52398-83-1 666. acetonitile, (dodecylsulfonyl)-.
......................................................................................................................................................................................................... 52821-30-4 667. thophene,3-bromo-2,3-dihydro-, 1,1-dioxide

................................................................................................................................................................................ 53336-42-8 668. 3H-indole, 2,3,3-trmethyl-5-(phenylsulfonyl)

................................................................................................................................................................................ 55203-59-3 669. 2-butanone, 3-methyl-, [4-(phenylsulfonyl)phenylhydrazone

..................................................................................................................................................... 55203-60--6 670. 1H-benzimidazollum, 2-(6-methoxy-2-benzofuranyl).1,3-dimethyl-5-(methytsulfonyl)-.

............................................................................................................. 55911-28-9 671. benzene, 1,1'-suffonylbis[4-(1-methylethyl)]-.

............................................................................................................................................................................... 57913-35-6 672. propane, 1,3-bis(ethenyisufonyl)-2,2-bis[(ethenylsuffonyl)m thyl]-.
......................................................................................................................................... 60345-53-1 673. l(2H)-quinolineethanol, 6-[[2-chloro-4-(methylsulfonyl)phenyl]azo]-3,4-dihydro-2,2,4,7-tetramethyl-.

................................................................................. 63134-03-2 674. 3-pyridinecarbonitrile, 5-[[2-chloro-4-(methysulfony)phenyl]azo]-4-methyl-2,6-bis[[3-(2-phenoxyethoxy)propyl]aniino]-

.............................................. 63281-10-7 675. disulfone, dihexyl

............................................................................................................................................................................................................................... 63450-69-1 676. propanenitrile, 3-[ethyt[4-[(6-(methylsulfonyl)-2-benzothiazolyllazo]phenyl]amino-.

........................................................................................................... 63467-01-6 677. ethanol, 2,2'-[[4-[[6-(methylsulfonyt)-2-benzothiazolyllazolphenylliminolbis-

....................................................................................................................... 63467-02-7 678. thiophene, 4-bromo-2,3-dichlorotetrahydro-, 1,1-dioxide

.............................................................................................................................................................. 65243-01-8 679. propanenitrile, 3-[ethyl[3-methy-4-[[2-(methylsulfonyl)-4-nitrophenylazolphenyllamino-.

................................................................................................. 67906-60-9 680. benzenesulfonlc acid, 3-[[4-[ethyl(phenytmethyl)aminojphenylazo]-4-[(4-methytphenyl)sulfonylJ-

................................................................................. 68400-40-8 681. benzenmine, 4-[(1-ethyl-2-methy-IH-indol-3-yl)[(4-methylphenyl)sulfony methy]-NN-dimethy-.

.................................................................................... 68912-03-8 682. benzenamine, 5-chloro-2-[(4-methylphenyl)sulfony -. ................................................................................................................................................................. 70146-09-7 683. 1H-pyrazol-5-amine, 3-methyl-4-[[4-(methylsuffonyl)-2-nitrophenyllazo]-l-phenyl-.

............................................................................................................... 70210-09-2 684. 3H-pWazol-3-imine, 2,4-dihydro-5-methyl-4-[[4-(methylsuffony)-2-nitrophenyllazo]-2-phenyI-.

............................................................................................. 70528-91-5
685. hydrazine, E4-(phenylsulfonyl)phenyl]-.

.......................................................................................................................................................................................... 70714-83-9 686. 3H-pyazol-3imine, 4-[[4-(ethytsulfonyl)-2-nitrophenyl]azo]-2,4-dihydro5-methyl-2-phenyl-.

............................................................................................... 70833-53-3

1.3.eRemovals. No chemicals were for the revisions." Under this authority, need of subchronic tests). These removed from the Priority List as a the Committee is revising the Priority revisions are listed inTable I above. result ofEPA responses to Committee List by designating two chemicals (4- The Priority List (Table 2) includes recommendations. vinylcyclohexane and sodium cyanide) designated, recommended with intent1.4 The TSCA section4(e) Priority that were previously recommended with to-designate and recommended
List. Section 4(e)(1](B) of TSCA directs intent-to-designate and adding one chemicals and chemical groups. the Committee to: .*** make such chemical (N-phenyl-1-naphthylamine) Individual chemicals in Priority List revisions in the [priority] list as it and four chemical groups (IRIS chemical groups are listed in Table I or determines to be necessary and *** chemicals, aldehydes, sulfones and the paragraph immediately following transmit them to the Administrator substantially produced chemicals in Table 1ofthis and previous Reports together with the Committee's reasons with appropriate notes that minimize ............................................................................

............................................................................

............................................................................

### Federal Register / Vol. 56, No. 44 / Wednesday, March 6, 1991 / Notices ambiguities related to TSCA section 8(a) and 8(d) reporting requirements. Table 2 containing the section 4(e) priority list

follows:

TABLE 2.-THE SEcTION4(E) PRIORrrY LIST
Enty Action Date

Brominated flame retardants

............................................. designated

.............. ............................. November 1989 4-vytcyclohexene designated. Novembr 1990
sodium cyanide

................................................................................. designated

.......................................................................... . November 1990 IRIS chenicals

. .- designated November 1990 chioroalkyl phosphates

.......................................................................... recommended with intent-to-designate

. . ......... . November 1988 Isocyanates

........ recommended with intent-to-designate May 1990 aldehydes

................................................................................................. recommended with Intent-to-designate

.................................. November 1990

imidazollum quaternary ammonium compounds

.. . recommended May 1988 ethoxylated quaternary ammonium compounds

................................. recommended

........................................................................ May 1988 butyraldehyde recommended November 1988 brominated flame retardasnts

.................................................................. recommended
........................................................................ November 1989 bromlnaeed flame ret arrntsrecommended

- May 1990 alkyl phosphates
..................................................................................... recommended
......................................................................... .. M ay 1990 

### ERIS chemicals recommended --- November 1990 N-phenyl-l-naphthyl'amlne

..................................................................... recommended
..................................................................... _ November 1990

sulfom p.d.... recommended..November 1990 substantially produced chemicals In need of subchronic tests
.......... recommended

.............................................................. ....... . November 1990

References

(1)Sixteenth Report ofthe TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency.TSCA Interagency Testing Committee, May 21,1985,50 FR20930-20939. Includes references toReports I through 15 and an annotated list ofremovals.

(2) Seventeenth Report of the TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, November 19, 1985, 50 FR47603- 47612.

(3) Eighteenth Report ofthe TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, May 19, 1986, 51 FR 18368-18375.

(4)Nineteenth Report ofthe TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, November 14, 1986, 51 FR 41417- 41432.

(5) Twentieth Report ofthe TSCA Interagency Testing Committee tothe Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, May 20, 1987, 52FR 19020-19026.

(6)Twenty-first Report oftheTSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, November 20, 1987, 52 FR 44830- 44837.

(7)

Twenty-second Report of theTSCA Interagency Testing Committee to the Administrator,Environmental Protection Agency. TSCA Interagency Testing Committee. May 20.1988,53 FR 18196-18210.

(8)Twenty-third Report of theTSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, November 16,1988, 53 FR 48282- 46278.

(9)Twenty-fourth Report ofthe TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, July 27, 1989, 54 FR 31248-31249.

(10)Twenty-fifth Report ofthe TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, December 12, 1989, 54 FR 51114- 51130.

(11) Twenty-sixth Report ofthe TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, June 5. 1990, 55 FR 23050-23082. Chapter 2-Recommendations of the Committee

2.1 Chemicalsrecommended for priorityconsideration by the FPA Administrator. As provided by section 4(e)(1}(B) ofTSCA, the Committee is revising the Priority List by designating
two chemicals that were previously recommended with intent-to-designate and adding one chemical and four chemical groups (see Table 1). The recommendation ofthese chemicals is made after considering the factors identified in section 4(e)(1)(A) and other relevant information, such as the chemical testing information deficiencies ofMember Agencies.

2.2 Designated chemicals-2.2.a 4- Vinylcyclohexane. 4-Vinylcyclohexane

was designated because there were no TSCA section 8(d) submissions that satisfied the National Institute for Occupational Safety and Health nominated testing information deficiencies. The rationale for the original recommendation with intent-todesignate appeared in the Committee's 25th Report (54 FR 51114.December 12, 1989).

Z.2.b Sodium cyanide.Sodium cyanide

was designated and the testing recommendations changed because discussions among the Department of Interior, the EPA and industry identified additional testing information deficiencies and because there was a general understanding that there were
no TSCA section 8(d) submissions that

were likely to satisfy the testing information deficiencies nominated by the Department ofInterior. The rationale for the original recommendation with intent-to-designate appeared in the Committee's 26th Report (55 FR 23050, June 5, 19901.

2.2.c.IRIS chemicals.At the request of EPA,.the Committee reviewed a subset ofchemicals that are listed on the Agency's Integrated Risk Information System (IRIS). IRIS is an electronic database, prepared and maintained by EPA, that contains health risk and EPA regulatory information on chemical substances. IRIS was developed for EPA staffin response to a growing demand for consistent risk information on chemical substances for use in decisionmaking and regulatory 

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### Federal Register / Vol. 56, No. 44 / Wednesday, March 6, 1991 / Notices

activities. Although IRISwas designed for EPA staff,it is also accessible to state and local environmental health agencies, private citizens, libraries and organizations through Dialcom, Inc.'s electronic mail telecommunications system. For more information contact IRISUser Support inEPA's Environmental Criteria and Assessment Office, Cincinnati, Ohio (513/569-7254

or FTS 684-7254).

The chemicals that EPA nominated to the Committee forhealth effects testing information deficiencies are those chemicals for which the Agency has determined that there is a lack of confidence in the available health effects data. TheEPA believes that the development ofreliable health effects data will increase the confidence in the data andreduce the uncertainties in the assessment ofrisk.EPA nominated the IRIS chemicals to the Committee to recommend testing thatwould provide reliable data.

The Committee-activated comprehensive networking and information exchange processes were used to facilitate communication and coordination ofchemical testing as intended by Congress and suggested by industry. The Committee considered unpublished studies in Member Agency's files, and past,present and future Member Agency activities. The Committee discussed studies conducted by NTP and EPA's Health Effects Research Laboratory and Environmental Research Laboratories, studies sponsored by NIOSH, studies used by OSHA and CPSC, studies submitted under TSCA as well as studies in FDA's files. The Committee learned about ongoing international activities, about ATSDR's data research needs, about EPA's Toxics Release Inventory (TRI) information, about Health Hazard Evaluations and Hazard Evaluation and Technical Assistance Reports, walkthrough surveys, etc., conducted by NIOSH, uses considered by the FDA. activities under other statutes, and so on. As part ofthe Committee's efforts to comprehensively consider testing information deficiencies, the Committee reviewed available information on physical/chemical properties and persistence as well as ecological effects and identified a number ofchemical fate and aquatic toxicity testing information deficiencies. EPA's Neurobehavioral Toxicology Branch also reviewed these chemicals forpotential neurotoxicology
concerns and the Committee identified neurotoxicity testing deficiencies.

EPAnominated several IRIS chemicals to the ITCto take advantage of (1)The Committee's comprehensive networking and information exchange capabilities that conserve resources and promote cost-effective testing required
or sponsored by U.S. Government organizations and (2) the opportunity to obtain recent production and exposure information and unpublished health and safety studies that are automatically required under TSCA section 8(a) and 8(d), respectively, for any Committee recommendation. For 13 IRIS chemicals, the Committee has comprehensively assessed available health effects, chemical fate and ecological effects information.As a result ofthese assessments, theCommittee is recommending 8 chemicals fortesting (see Table 1), returning 2 chemicals to the EPA because the Committee's review identified health effects data that appear tobe sufficient to reduce the uncertainty associated with risk assessments (vanadium pentoxide, CAS 1314-62-1 and hydrogen sulfide, CAS 7783--06-4, returning 2chemicals for which there are uncertainties related to testingunder TSCA (HMX, CAS 2691- 41-0and ammonium sulfamate, CAS 7773-06-0), and returning I chemical for which domestic production is being substantially reduced (CFC-113, CAS 76-13-1). The Committee identified algal toxicity and aquatic invertebrate acute and chronic toxicity testing deficiencies forvanadium pentoxide, butisnot recommending testing at this time because,in a future Report itplans to recommend such testingfor aninorganic chemical group. The EPArequested that the Committee designate 6 ofthe 8IRIS chemicals.Five ofthe IRIS chemicals thatwere listed inTitle III ofthe 1990 amendments oftheClean AirAct (acetophenone, acrylic acid,NNdimethylaniline, 2,4-dinitrophenol and phenol) were recommended for inhalation testing to reduce the uncertainty associated with risk assessments thatneed to be developed forthese chemicals. The Committee is continuingto review information on numerous IRISchemicals, including several that are listed in the Clean Air Act.

Summaryof recommendedstudies. Recommended studies are summarized inTable Iabove. Acrylic Acid Physical andChemicalInformation CAS Number: 79-10-7 Synonyms and Trade Names: Acroleic acid. 2-propenoic acid.

Empirical Formula: CaILOt Molecular Weight: 72.1 Physical State at 25"C: Liquid 

### Description ofChemical: Corrosive liquid, acrid odor andfumes (Ref.164, Windholz et aL. 1983) Melting Point: 13.5 (Ref.96, Lide,1990) Boiling Point: 141.6 (Ref.34,Daubert and Danner, 1985)

Vapor Pressure: 4.00 mm 

### Hg @ 25 °C (Ref.34,Daubert and Danner, 1985)

Specific Gravity: 1.0621 (Ref. 164, Windholz et al., 1983)

Log Octanol/Water Partition Coefficient: 0.161 (Ref. 128, PCGEMS, 1987)

Water Solubility at25 C: miscible (Ref. 130, Perry and Green, 1984)

Log K.: 1.5 (Ref. 100, Lyman etaL 1982) Henry's Constant: 1.17 X 10 " atmm mole' (Ref. 75,Hine and Mookerjee, 1975)
Rationale forRecommendations
A. ExposureInformationProduction/use/disposol/exposure/ release. In 1988, 1,0658,834,000 lbs of acrylic acid were produced at 4 different U.S. facilities (Ref. 159,U.S ITC, 1989). Acrylic acid has the following uses: surface coatings-25 percent; polyacrylic acid and salts (including superabsorbent polymers, detergents, water treatment and dispersants)-20 percent;,textiles and nonwovens--13 percent; exports--12 percent; adhesives and sealants-9 percent; leather and polishes-4 percent, paper coating-3 percent; miscellaneous acid and ester

uses (including specialty acrylates)--8 percent (Ref.29, CMR, 1986).

B. Evidence forexposure-Human exposure.The National Occupational Exposure Survey (NOES) indicates that 56,512 workers (14,643 female) are potentially exposed to acrylic acid; 82 percent ofthis exposure is from the use oftrade name products containing this compound (Ref. 120, NIOSH, 1990). Potential exposure to acrylic acid was associated with 22 different industrial classifications. OSHA's Permissible Exposure Limit {PEL) of 10ppm 8-hour Time Weighted Average (TWA) and a skin notation are based on irritation by analogy to acetic acid (54 FR 2614-2621, January 19,1989). OSHA concluded that these were necessary to protect workers from nasal and eye irritation, but NIOSH believed the limit should be lower based on recent studies demonstrating nasal mucosa degeneration, pulmonary function changes and skin absorption (54 FR 2621).

Environmental exposure.In a survey of 172 product/process effluents at 40 different petrochemical manufacturing sites, 28percent of the samples contained acrylic acid at concentrations greater than 0.5 ppm (Ref.165, Wise and Fahrenthold, 1981). According to the TRI, 832,056 lbs of acrylic acid were released to the atmosphere in 1987, while 16,126 and 6,153 

### lbs were released to water and land, respectively (Ref. 153, TRI, 1990). For 1988, TRI indicates that 

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### Federal Register / Vol. 56, No. 44 / Wednesday, March 6, 1991 1 Notices

798,567 lbs were released to air, 15,950 lbs were released to land, and 16,396 lbs
were released to water (Ref.153, TRI, 1990).
I. Chemical Fate Information

In the atmosphere, acrylic acid is expected to undergo rapid oxidation with gas phase hydroxyl radicals and

ozone (Ref.8, Atkinson, 1987;Ref. 9, Atkinson and Carter, 1984). In water, acrylic acid is not expected to significantly volatilize to the atmosphere, nor is it expected to adsorb to sediment or suspended organic matter (Ref.100, Lyman et al., 1982). Limited screening studies suggest that acrylic acid will biodegrade under aerobic conditions (Ref.19, BIOLOG, 1990; Ref. 127, Pahren and Bloodgood, 1961). Avialable persistence data are probably inadequate to predict the biodegradation rate ofacrylic acid in the environment, because the data were not generated using test systems that simulated insitu biodegradation. The Committee recommends chemical fate testing because there are insufficient data to reasonably determine or predict the persistence ofacrylic acid and because there are potentially substantial environmental releases. II.HealthEffects Information

Acrylic acid wasrapidly absorbed, metabolized and excreted following oral
or inhalation exposure (Ref.88, Kutzman et al., 1982).

Effects identified in a 3-month drinking water study ingroups of15 male and 15 female Fischer F-344 rats given drinking water that provided doses of83, 250 or 750 mg acrylic acid per kg per day included decreased food and water intake, reduced body weights, and alterations in organ weights (Ref. 39, DePass et al., 1983). Reduced weight gain,lethargy and nasal irritation were observed in the high dose ingroups of4- 8 Alderley Park rats of both sexes exposed by inhalation to 80 or 300 ppm acrylic acid, 6hours per day, 5days per week for4 weeks (Ref.57, Gage, 1970). More recent inhalation studies in groups of 5male and 5female rats and mice exposed to 25 to 223 ppm acrylic acid, 6 hours per day, 5days per week for 2 weeks (Ref. 112, Miller et al., 1979) and ingroups of 15 male and female F-344 rats and B6C3F1 mice exposed to 5to 75 ppm acrylic acid, 6hours per day, 5days per week for 13 weeks (Ref.113, Miller et al., 1979;Ref. 114, Miller et al., 1981) identified mice as more sensitive than rats to the effects ofinhalation exposure (nasal irritation and degeneration ofthe olfactory epithelium).

The fetuses ofSprague-Dawley rats given 2 4,4.8 or 8.0 mg per kg intraperitoneal injections ofacrylic acid

on days 5, 10 and 15 ofgestation had a dose-related decrease in body weights and an Increase in the incidence ofgross and skeletal malformations (Ref. 140, Singh et al., 1972). There isprobably insufficient information on the effects of treatment to characterize the developmental toxicity ofacrylic acid.

Maternal effects (nasal irritation and reduced rate ofbody weight gain) but no fetal effects were observed in the 2 highest dose groups ofSprague-Dawley rats exposed to 40, 120 or 360 ppm acrylic acid by inhalation on gestation days 6 to 15 (Ref. 87, Klimisch and Hellwig, 1989). Decreased fertility in females, decreased numbers oflive pups per litter, decreased offspring body weight, and a decreased percentage of pups weaned were observed in a onegeneration reproduction study in groups of 10 male and 20 female rats that were provided acrylic acid inthe drinking water at doses of83, 250 or 750 mg per kg per day (Ref. 39, DePass et al., 1983). A 2-generation study may be necessary to characterize the reproductive effects ofacrylic acid.

Acrylic acid was negative in the

reverse mutation test in Salmonella (Ref. 97, Lijinsky and Andrews, 1980; Ref. 13, BASF, 1989), did inhibit incorporation of thymidine into DNA and uracil into RNA in S. aureusand E. coli (Ref.60, Glombitza and Heysen, 1971) and was positive for mutagenicity and clastogenicity in L5178Y mouse lymphoma cells (Ref. 115, Moore et al., 1988). Acrylic acid was positive for chromosomal aberrations in an in vitro test in Chinese hamster ovary cells (Ref. 106, Microbiological Associates, 1986), but did not induce chromosomal aberrations inthe bone marrow cells of rats treated by gavage for up to 5 days (Ref.107, Microbiological Associates, 1986). In viva testing may be necessary to characterize the mutagenicity of acrylic acid.

Acrylic acid was negative in 1 skin painting study in 40 male C3H/Hej mice treated with 1 percent acrylic acid in acetone thrice weekly for life (Ref.40, DePass et al., 1984), but was weakly positive as a complete carcinogen and

as a promoter in a study in which 30 female ICR/HA mice were treated with 4 mg acrylic acid in acetone thrice weekly for 1.5 years (Ref.32, Cote et al., 1986). IARC (Ref. 79, IARC, 1987) assigned acrylic acid to Group 3; not classifiable as to its carcinogenicity to humans. The National Cancer Institute (NCI) reviewed a draft chronic study conducted by the Basic Acrylic Monomer Manufacturers Association and supports the EPA nomination and Committee recommendation for inhalation oncogenicity testing. Available data are probably insufficient to characterize the oncogenic potential of acrylic acid because they were not developed using an appropriate route of administration.

The Committee recognizes that NIOSH has Health Hazard Evaluations, Hazard Evaluation and Technical Assistance reports and walk-through survey reports for acrylics that are available from NTIS and the Committee is placing a list ofthese documents in the public docket. A table containing a list ofFYI studies submitted to EPA is also contained in the public docket. The Committee recommends health effects testing because there are potentially substantial exposures, because there are insufficient data to reasonably determine or predict health effects and because these data are needed to reduce the uncertainty associated with risk assessments for acrylic acid.
Ill. Ecological Effects Information

The Committee recognizes that acute LC, 5ovalues are available for fresh water fish, that growth ofblue-green and green algae is inhibited at 0.15 and 18 mg/L acrylic acid, respectively and that protozoan growth is inhibited at acrylic acid concentrations ranging from 0.9 to 20 mg/L (Ref.4, AQUIRE, 1990]. The Committee is not recommending ecological effects testing at this time. Acetophenone Physical andChemicalInformation CAS Number: 98-86-2 Synonyms and Trade Names: Phenylmethylketone, hypnone, acetylbenzene

Empirical Formula: Cs1-10 Molecular Weight: 120.2 Physical State at 25" C: Liquid Description ofChemical: Colorless liquid with sweet, pungent, odor and taste (Ref. 136, Sax and Lewis, 1987)

MeltingPoint: 19.6 C(Ref. 134, Riddick et al., 1986)

Boiling Point: 202' C(Ref. 134, Riddick et al., 1986)

Vapor Pressure: 0.397 mm Hg @25' C (Ref. 163, Weber et al., 1981)

Specific Gravity: 1.033 (Ref. 184, Windholz et al., 1983)

Log Octanol/Water Partition Coefficient: 1.58 (Ref.68, Hansch and Leo, 1981)

Water Solubility at 25' C: 6,130 mg/L (Ref.69, Hasset et al., 1980)

Log Koc: 1.65 (Ref.69, Hasset et al., 1980) Henry's Constant: 1.09 X 10 s atm m 3 mole' (Ref.100, Lyman et al., 1982)
Rationale forRecommendations
A. ExposureInformationProduction/use/disposal/exposure/ release.Acetophenone is produced in substantial volumes; actual production volumes are CBI. Acetophenone is used 

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### Federal Re ister / Vol. 56, No. 44 / Wednesday, March 6, 1991 / Notices

in fragrances and flavorings, and as a solvent, chemical intermediate for pharmaceuticals and resins, polymerization catalyst, and as a photoinitiator (Ref.27, Chemcyclopedia, 1989;Ref. 136, Sax and Lewis, 1987).

B. Evidence forexposure-Human exposure.The NOES survey indicates that 39,880 workers (17,664 female) were potentially exposed to acetophenone in 18 different industrial applications (Ref. 120, NIOSH, 1990). Ofthese workers, 97 percent were potentially exposed during the use oftrade name products containing acetophenone. Acetophenone has been detected in U.S. drinking water supplies. In a survey of10 U.S. cities between 1969 and 1972, acetophenone
was found inPhiladelphia's drinking water, on 7 different occasions, at a concentration ofapproximately 1.0 pg/L (Ref.84, Keith et al., 1976;Ref. 149, Suffet et al., 1980). Acetophenone was also detected in drinking water samples ofBritain during 1977-79 (Ref.53, Fielding et al., 1981).

Environmental exposure. Acetophenone was detectedin 131 samples obtained from 28 industries and POTWs at amaximum concentration of 16 ppm (Ref.138, Shackelford et al., 1983). Of204 sites monitored in 14 heavily industrialized river basins in the U.S., acetophenone was detected in 3of them at a concentration of I to 3ppb (Ref.51, Ewing et al., 1977). The STORET database indicates that acetophenone has been foundin 1 surface water sample monitored during the 1980's (Ref. 148, STORET, 1990). Acetophenone was detected in both surface and deep water samples from the Baltic Sea, 1979-80, and thought to 

### arise from the photooxidation offuel oil components, suggesting that acetophenone is likely to be present in water polluted by fossil fuels (Ref.46, Ehrhardt et al., 1982 Ref.45, Ehrhardt, 1987). In a compilation ofair monitoring data collected between 1970 and 1987, the median concentration of acetophenone in urban and source dominated sites was 0.041 and 0.094 ppb, respectively (Ref. 139, Shah and Heyerdahl. 1988). I.Chemical Fate Information

In the atmosphere, acetophenone is expected to slowly degrade by the gas phase oxidation withphotochemically produced hydroxy radicals (Ref.8, Atkinson, 1987). Its fate in water will depend on photolytic degradation (Ref. 44, Draper and Crosby, 1983; Ref.90, 

### Lande et al., 1976), volatilization to the atmosphere (Ref.102, Mackay et al., 1982), and biodegradation (Ref.18, BIODEG, 1990;Ref. 99, Ludzack and Ettinger, 1963). The available data indicate that acetophenone will not significantly adsorb to soil (Ref.157, U.S. EPA, 1987). The Committee is not 

### recommending chemical fate testing at this time.
II. Health Effects Information

Available pharmacokinetic data were limited to in vitro (Ref.55, Fraser et al., 1967;Ref. 92, Leibman, 1971; Ref.90, Lande et al., 1976) and invivo (Ref.151, Thierfelder and Daiber, 1923; Ref. 152, Thierfelder and Klenk, 1924; Ref. 141, Smith et al., 1954: Ref. 85, Kiese and Lenk, 1974) metabolism studies using rabbits, rats, humans and dogs. Quantitative data regarding absorption, distribution, or excretion may be necessary to characterize the oral and inhalation pharmacokinetics of acetophenone.

Subchronic studies failed to identify adverse effects in groups of5 male and 5 female albino rats fed diets containing acetophenone at levels of0.003. 0.05, 0.125 or 0.2 percent for30 days (Ref. 142, Smyth, 1946) or in groups of 10 male and 10 female Osborne-Mendel rats fed diets containing 1,000, 2,500 or 10,000 ppm acetophenone for 17 weeks (Ref.66, Hagan et al., 1967). An inhalation study reported a specific pattern of degeneration ofthe olfactory bulb in groups of4 Wistar rats continuously exposed to acetophenone vapors for 1 week to 3 months (Ref.132, Pinching and Doving, 1974). Other parameters of toxicity were not evaluated In this study. Although respiratory irritation

was indicated in a number of studies, there are probably insufficient data to characterize the subchronic inhalation toxicity ofacetophenone.

Reproductive toxicity data were limited to a study that reported no effects on length ofgestation or postnatal development in the offspring ofrats exposed dermally at 0.48 mg/kg

on days 10 to 15 ofgestation (Ref.89, Lagno and Bakhtizna, 1969). A 2- generation study may be necessary to characterize the reproductive effects of acetophenone.

Acetophenone was negative for mutagenicity in 3 strains ofSalmonella (Ref. 47, Elliger et al., 1984). Additional testing in non-bacterial systems may be necessary to characaterize the mutagenicity of acetophenone.

Anger and Johnson (Ref.3, 1985) suggested that acetophenone could be neurotoxic. Data were not located regarding the oncogenicity of acetophenone.

The Committee recognizes that NIOSH has a Hazard Evaluations and Technical Assistance report for acetophenone that is available from NTIS and the Committee isplacing the 

### reference for thisreport in the public docket. The Committee recommends health effects testing because there are potentially substantial exposures, because there are insufficient data to reasonably determine orpredict health effects and because these data are needed to reduce the uncertainty associated with risk assessments for acetophenone. II. Ecological Effects Information

The Committee recognizes that acetophenone is acutely toxic to fathead minnows; the LC0

### values ranged from 155 to 162 mg/L (Ref.4, AQUIRE, 1990). The Committee is not recommending ecological effects testing at this time. Phenol PhysicalandChemicalInformation

CAS Number. 108-95-2 

### Synonyms and Trade Names: Carbolic acid, hydroxybenzene,phenylic acid, benzophenol.

EmpiricalFormula: C41160 Molecular Weight: 94.1 Physical State at 25"C. Solid Description ofChemical: Colorless, acicular crystals orwhite,crystalline mass (Ref.164, Windholz 

### et al., 1983)

Melting Point: 43' 

### C(Ref. 70, Hawley, 1981)



### Boiling Point: 182"C(Ref.70,Hawley, 1981)

Vapor Pressure: 0.35 mm Hg @25*C 

### (Ref.81, Jones, 1960)

Specific Gravity: 1.071 (Ref. 164, 

### Windholz et al., 1983)



### Log Octanoi/Water Partition Coefficient: 1.48 

### (Ref.68,

### Hansch and Leo, 1981)



### Water Solubility at 25*C: 93.000 W/L (Ref.23, Callahan et al., 1979)

Log Ko,: 1.20 (Ref.22, Boyd, 1982) Henry's Constant: 3.33 X 10 , 7 atm m3 mole" 

### (Ref. 56, Gaffney 

### et al., 1987)



### pK.: 9.994 

### (Ref.137, Serjeant and Dempsey. 1979) 

### Rationale forRecommendations
A. ExposureInformationProduction/use/disposal/exposure/ release.In 1988, 7U.S. facilities produced 3,561,734,000 pounds ofphenol (Ref. 159,U.S. ITC, 1989) and 13 facilities

were listed as manufacturing this compound in 1989 (Ref. 145, SRI, 1989); Phenol has the following uses:phenolic resins--38 percent; synthesis of bisphenol A-23 percent; synthesis of caprolactan--17 percent; synthesis of alkylphenols-4 percent; synthesis of aniline-3 percent; miscellaneous uses5percent; exports-"6 percent (Ref.30, CMR, 1987). The miscellaneous uses of phenol include the synthesis ofadipic acid, salicylic acid, phenolphthalein. pentachlorophenol, acetophetidine, picric acid, and pharmaceuticals, as a selective solvent forrefining lubricating 9553

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oils, germicidal paints, laboratory reagent, dyes and indicators, slimicide, biocide, and as a general disinfectant (Ref. 136, Sax and Lewis, 1987). Many products containing phenol are utilized by consumers. The Committee is concerned with the potential for exposure to phenol because ofits very high production volume, potential for release, and presence in commercial and

consumer products.

B.Evidenceforexposure--Human exposure.Phenol is used in a variety of commercial applications, many ofwhich

can lead to worker exposure. The NOES conducted during 1981-1983 by NIOSH estimated that 341,516 workers (108,851 female) were potentially exposed to phenol in 35 different industrial categories (Ref. 120,NIOSH, 1990). In a compilation ofair monitoring data collected between 1970 and 1987, the

mean concentration ofphenol in suburban and urban areas was reported

as 0.015 and 6.883 ppb, respectively (Ref. 139, Shah and Heyerdahl, 1988). The concentration ofphenol in the air of Portland, OR, during 7 rain events in 1984 was 56 to 105 ppt, while the concentration ofphenol in the rain ranged from 75 to 1,200 ppt (Ref.93, Leuenberger et al., 1985). From 1977 to 1979, phenol was detected in 36 percent ofdrinking water supplies inEngland, which were drawn from groundwater, river water, and reservoirs (Ref.53, Fielding et al., 1981). It has also been detected in U.S. drinking water supplies (Ref. 49, EPA, 1980; Ref. 119, Nicola et al., 1987). Phenol is used in numerous
consumer products indicating a potential for exposure to the general population.

Environmental exposure.Phenol was detected in 738 samples obtained from 33 industries and publicly owned treatment works (POTWs) at a maximum concentration range of7.5 ppb to 530 ppm (Ref.138, Shackelford et al., 1983). Data from the STORET database indicates that phenol was found in 42.1 percent ofindustrial effluent samples obtained from 1980-83, at a median concentration of 10 ppb (Ref.146, Staples et al., 1985). The STORET database also indicates thatphenol was found in 13 percent ofambient surface water samples, and 9 percent of sediment samples (Ref. 146, Staples et al., 1985), and also ingroundwater samples (Ref, 148, STORET, 1990). Phenol was detected in 4 percent of 86 samples obtained during the National Urban Runoff Program of1982, at concentrations ranging from 3 to 10 ppb (Ref. 31, Cole et al., 1984). According to the TRI for 1987, 8,100,731 lbs ofphenol

were released to the air, 402,579 pounds were released to water, and 1,098,624 lbs were released to land (Ref. 153, TRI, 1990). For 1988, TRI indicates that 10,155,101 lbs were released to air, 262,127 lbs were released to water, and 2,102,250 lbs were released to land (Ref. 153. TRI. 1990).
1.Chemical Fate Information

In the atmosphere, phenol will undergo rapid oxidation during the daytime by the reaction with photochemically produced hydroxyl radicals and at night with nitrate radicals (Ref. 8, Atkinson, 1987). Phenol is not expected to significantly volatilize from water to the atmosphere; however, it is likely to undergo rapid biodegradation under both aerobic and anaerobic conditions (Ref.18, BIODEG, 1990). Biodegradation ofphenol is well documented in the literature; it is often the benchmark for determining the rate ofbiodegradation of other organic compounds. Phenol may also undergo oxidation by alkoxy radicals in sunlit waters containing humic materials (Ref. 108, Mill and Mabey, 1984). Phenol is unlikely to adsorb to soil (Ref.78, Howard et al., 1989), although in soils with substantial metal or clay content, phenol may be strongly adsorbed in a pH dependent process (Ref.7, ArtiolaFortuny and Fuller, 1982). The Committee is not recommending chemical fate testing at this time. 11. Health Effects Information

Phenol was readily absorbed through the gastrointestinal tract, lungs, and skin (Ref.37, Deichmann and Keplinger, 1981) and was widely distributed inrats and rabbits (Ref. 35, Deichmann, 1944; Ref. 95, Liao and Oehme, 1981). At lethal oral doses (0.5 g/kg in rabbits), itwas eliminated by oxidation to CO 2 and urinary excretion as free or conjugated phenol (Ref.37, Deichmann and Keplinger, 1981). At low (0.01 to 50 mg/ kg) doses in several species treated by oral, intravenous orintramuscular administration, elimination was largely by urinary excretion offree and conjugated phenol; the proportion offree and conjugated phenol varied with species (Ref. 37, Deichmann and Keplinger, 1981; Ref. 24, Capel et al., 1972; Ref. 104, Mehta et al., 1978; Ref. 111, Miller et al., 1976; Ref. 82, Kao et al., 1979). Quantitative data regarding absorption, distribution, or excretion may be necessary to characterize the oral and inhalation pharmacokinetics of phenol.

Subchronic exposure of 17humans to drinking water containing phenol (10 to 40 mgper person per day) resulted in a burning sensation in the mouth, sores in the mouth, and diarrhea (Ref. 11, Baker et al., 1978). Groups of 10 male and 10 female F344 rats and B6C3F1 mice given phenol in drinking water at levels of 100, 300, 1,000, 3,000, or 10,000 ppm for 90 days exhibited decreased water consumption and weight gain at the high dose, but no histopathological effects (Ref. 116, NCI, 1980). Gavage treatment ofrats with 50 or 100 mg/kg, 5 days per week for 6 months resulted in slight (unspecified) liver and kidney effects (Ref.43, Dow Chemical Co., 1945). Decreased weight gain at the 2 highest doses was the only effect observed in rats given drinking water containing phenol at 800, 1200, 1,600, 2,000 or 14,000 ppm for 12 months (Ref. 36, Deichmann and Oesper, 1940). In a 2-year study, groups of50 male and female B6C3F1 mice and F344 rats given drinking water containing 2,500 or 5,000 ppm phenol exhibited reduced water consumption and body weight gain but no clear evidence ofcompound-related histopathological alteration (Ref.116, NCI, 1980).

In subchronic inhalation studies, increased mortality and CNS signs were reported in 12 guinea pigs and histological lesions were reported in the heart, liver, and kidneys ofguinea pigs and 6 rabbits exposed to 100 to 200 mg/

m

3 phenol for 7 hours per da, 5 days per week for 6 to 13 weeks; effects were not observed in 25 rats similarly exposed for 11 weeks (Ref. 35, Deichmann et al., 1944). Slightly reduced body weight gain, but no other evidence of toxicity, was observed in 50 rats and 10 monkeys, whereas increased stress test endurance was observed in 100 mice exposed by inhalation to 19 mg/m 3 phenol for 8 hours per day, 5 days per week for 90 days (Ref. 135, Sandage, 1961). A 15-day study associated behavioral effects with continuous inhalation exposure ofrats to 100 mg/m 3 phenol (Ref. 33, Dalin and Kristoffersson, 1974). There are probably insufficient data to characterize the subchronic inhalation toxicity ofphenol, because existing studies were not sufficiently comprehensive in scope to identify effects on the respiratory tract and thresholds for inhalation exposure.

Anger and Johnson (Ref. 3, 1985) suggested that phenol could be neurotoxic.

A standard developmental toxicity gavage study reported reduced fetal body weight in the high dose in groups of20 to 22 CD rats treated with 30, 60 or 120 mg per kg per day on gestation days 6 to 15 and maternal mortality, decreased body weight and CNS effects and reduced fetal body weight and increased incidence of cleft palate at the high dose in CD mice treated with 70, 

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140 or 280 mg per kg per day on days 6 to 15 gestation 

### (Ref.121, NTP, 1983). Maternal weight loss at the highest dose, but no effects on fetuses or offspring were reported in a developmental toxicity screening test with a single 100, 333, 667 or 1,000 mg/kg gavage dose given to groups of 12 to 13 Sprague-Dawley rats on day 11 of gestation (Ref. 83, Kavlock, 1990).

A multi-generation drinking water study identified adverse effects on offspring growth and survival, but failed to adequately evaluate effects on reproductive function and postnatal survival in rats given drinking water containing 100 to 12,000 ppm phenol (Ref.73, Heller and Pursell, 1938). A study designed to adequately evaluate effects on reproductive function and postnatal survival may be necessary to characterize the reproductive effects of phenol.

The Committee recognizes that NIOSH has a Hazard Evaluations and Technical Assistance Report, walkthrough surveys, etc. for phenol that are available from NTIS and the Committee is placing a list ofthese documents in the public docket. A table containing a list ofTSCA section 8(d) studies submitted to the EPA is also contained in the public docket for the 27th ITC Report. ATSDR published their priority toxicity data needs for phenol (55 FR 11566, March 28, 1990) and supports the EPA nomination and Committee recommendation forhealth effects testing. The Committee recommends health effects testing because there are potentially substantial exposures, because there are insufficient data to reasonably determine or predict health effects and because these data are needed to reduce the uncertainty associated with risk assessments for phenol.
III. Ecological Effects Information

The ecological effects of phenol have recently been reviewed by Walker (Ref. 160, Walker, 1988). The Committee is not recommending ecological effects testing at this time. N,N-Dimethylaniline Physical andChemicalInformation CAS Number: 121-69-7 Synonyms and Trade Names: Dimethylphenylamine, 

### ,Ndimethylbenzeneamine, xylidene

Empirical Formula: C@H 1N Molecular Weight: 121.2 Physical State at 25* C: Liquid Description ofChemical: Yellowish to brownish oily liquid (Ref.136, Sax and Lewis, 1987)

Melting Point: 2.4" C(Ref. 134, Riddick et al., 1986) BoilingPoint: 194* C(Ref. 134, Riddick et al., 1986)

Vapor Pressure: 0.518 mm 

### Hg @ 250 C (Ref.163, Weber et al., 1981)

Specific Gravity: 0.956 

### (Ref.136, Sax and Lewis, 1987)

Log Octanol/Water Partition Coefficient: 2.31 (Ref. 68, Hansch andLeo, 1981)

WaterSolubility at 25° C: 1,450 mg/L (Ref.26, Chaoet al., 1983)

Log K.: 1.90 (Ref. 100, Lyman etal., 1982) Henry's Constant: 5.68 X 0'atmm 3 mole- (Ref.100,Lyman et al., 1982)

pK.: 5.15 (Ref. 26, Chao et al., 1983)
Rationale forRecommendations
A. ExposureInformationProduction/use/disposal/exposurel release.In 1979, domestic production of N,N-dimethylaniline was 13.7 million pounds (Ref.158, U.S. ITC, 1980). Information on current production volumes is CBI, but production is substantial.NN-Dimethylaniline is used in dyes, as a synthetic intermediate for vanillin, pharmaceuticals, and other compounds, solvent, stabilizer, and polymerization catalyst (Ref. 91, Lawrence and Marshall, 1985; Ref. 136, Sax and Lewis, 1987).

B. Evidence forexposure-Human exposure.The NOES survey estimated that 28,048workers (7395 females were potentially exposed to NNdimethylaniline in 9 different industrial classifications (Ref. 120, NIOSH, 1990). Ofthese workers, 39 percent were potentially exposed during the use of trade name products containing this compound.

Environmental exposure.NNdimethylaniline was detected in8 samples obtained from 3 industries and POTWs at a maximum concentration of 3.1 ppm (Ref. 138, Shackelford et al., 1983). According to TRI, 129,829 lbs of N,N-dimethylaniline were released to the air, 17,613 pounds were released to water, and 250 lbs were released to land in 1987 (Ref. 153, TRI, 1990). For 1988, TRI indicates that 98,905 lbs were released to air, 250 lbs were released to land, and 19,967 lbs were released to water (Ref.153, TRI, 1990). NNDimethylaniline was detected in soil samples obtained near the bank ofthe Buffalo River, NY, 1979 at concentrations of 10 to40 ppm (Ref. 118, Nelson and Hites, 1980). NNDimethylaniline was foundin the Rhine River, Germany, in 1984 (Ref. 144, Sontheimer et al., 1985) and in the Wall River, Netherlands, in 1974 at a maximum concentration of3.6 ppb (Ref. 105, Meijers and Vanderleer, 1976). NNDimethylaniline was qualitatively detected in water from Lake Ontario, but not Lake Erie (Ref.64, Great Lakes Water Quality Board, 1983). 

### I.Chemical FateInformation N,N-dimethylaniline is expected to undergo rapid atmospheric oxidation by reaction with photochemically produced hydroxyl radicals, ozone, and with nitrate radicals at night (Ref. 8,Atkinson et al., 1987). In water,NN

### dimethylaniline is expected to degrade by itsreaction with singlet oxygen (Ref. 65, Haag and Hoigne, 1985), and alkoxy radicals (Ref. 108, Mill etal., 1980) in sunlit waters. Biological processes are also likely to remove NNdimethylaniline from the aquatic compartment (Ref. 18, BIODEG, 1990;, Ref. 117, Niemi etal., 1987), but there are uncertainties associated with its fate in wastewater treatment facilities. It is not expected to volatilize from water to the atmosphere noris itlikely to adsorb to soil (Ref. 100, Lyman et al., 1982). Available persistence data are probably inadequate to predict the activated sludge biodegradation ofNNdimethylaniline, because data were not generated using test systems that simulated insitu wastewater treatment. The Committee recommends chemical fate testing because there are insufficient data to reasonably determine orpredict the persistence of N,N-dimethylaniline and because there

arepotentially substantial environmental releases.
II.Health Effects Information

Data related to the pharmacokinetics ofNN-dimethylaniline were limited to several invitro metabolism studies with rat and rabbit microsomal enzymes (Ref. 6, Arrhenius, 1968; Ref. 72, Heinze et al., 1970; Ref. 155, Uehleke et al., 1971; Ref. 

### 17, Bickel et al., 1971; Ref. 166, Ziegler and Gold, 1971; Ref.42,Devereux and Fouts, 1974; Ref. 133, Rane, 1974; Ref. 76, Hlavica and Kehl, 1974; Ref. 77, Hlavica and Kehl, 1976; Ref. 16, Beije and 

### Arrhenius, 1978; Ref. 63, Gorrod et al., 1979; Ref. 62, Gorrod and Gooderham, 1981; Ref. 124, Ohmiya and Mehendale, 1983; Ref. 125, Olsson et al., 1983; Ref. 67, Hamill and Cooper, 1984; Ref. 123, Odenbro and Arrhenius, 1984; Ref. 126, Olsson et al., 1984; Ref.42, Devereux et 

### al., 1985) and inviva metabolism studies in rats, rabbits and dogs (Ref.74, Hildebrandt, 1907; Ref. 48, Elson et al., 

### 1946; Ref. 86, Kiese and Renner, 1974). Quantitative data regarding absorption, distribution, or excretion may be necessary to characterize the oral and inhalation pharmacokinetics ofNNdimethylaniline.

A 13-week gavage study (that included comprehensive histopathological examination) in groups of10 male and 10 female F344/N 9555

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rats and B6C3F1 mice treated with 31.25, 62.5, 125, 250 or 500 mg/kg for 5 days per week identified the erythrocyte and the spleen as the most sensitive target organs in both species; however, a NOAEL was not reported (Ref.1, Abdo et al., 1984; Ref. 122,NTP. 1989). Compound-related clinical signs included lethargy in rats and mice and cyanosis in rats.The only inhalation study available was a brief abstract that reported altered muscle chronaxie and evidence ofhemolytic anemia in the high dose group ofrats continuously exposed for 100 days to 0.04 or 0.3 mg/

m

3 (Ref. 103, Markosyan, 1969). There

are probably insufficient data to characaterize the subchronic inhalation toxicity ofNN-dimethylaniline, because existing studies were not available in sufficient detail to identify effects on the respiratory tract and thresholds for inhalation exposure.

Anger andJohnson (Ref.3, 1985) suggested that NN-dimethylaniline could be neurotoxic.

A 2-year chronic toxicity-oncogenicity gavage study ingroups of50 male and 50 female F344/N rats treated with 3 or 30 mg/kg, 5 days per week and similarly sized groups ofB6C3F1 mice treated with 15 or 30 mg/kg, 5 days per week identified the rat as more sensitive than the mouse to the noncarcinogenic effects ofNN-dimethylaniline on the erythrocyte and spleen (Ref. 122, NTP, 1989). This study also reported some evidence of carcinogenicity in male rats (sarcomas and osteosarcomas ofthe spleen) and equivocal evidence of carcinogenicity in female mice (squamous cell papillomas ofthe forestomach).

Mutagenicity data were limited to negative results for reverse mutation in four strains ofSalmonellaand positive results for forward mutation inmouse lymphoma L5178Y cells and for sister chromatid exchange and chromosomal aberrations in Chinese hamster ovary cells (Ref.122, NTP, 1989). In vivo testing may be necessary to characterize the mutagenicityofNN-dimethylaniline.

Data regarding reproductive and developmental toxicity were limited to a study in 50 CD-1 albino mice treated with NN-dimethylaniline in corn oil at 365 mg per kg per day on gestation days 7 to 14; maternal mortality, but no effects on body weight or viability ofthe neonatal offspring were reported (Ref. 131, Piccirillo et al., 1983). A 2- generation study designed to adequately evaluate effects on body weight or viability ofthe neonatal offspring may be necessary to characterize the reproductive effects ofN,Ndimethylaniline. The Committee recognizes that OSHA has recently reconsidered the PEL for occupational exposure (54 FR 2654). The Committee recognizes that NIOSH has Health Hazard Evaluations and other reports forNN-dimethylaniline that are available from NTIS and the Committee is placing a list of these documents in the public docket. The Committee recommends health effects testing because there are potentially substantial exposures, because there are insufficient data to reasonably determine or predict health effects and because these data

are needed to reduce the uncertainty associated with risk assessments for N,N-dimethylaniline.
III. Ecological Effects Information

Algal toxicity data are limited to an algal bioassay (Ref. 15, Batterton et al., 1978) and a study ofenergy metabolism enzymes in marine algae (Ref. 5, Armstrong et al., 1981). Acute aquatic toxicity studies are available for a ciliated protozoan and several species offish (Ref. 4,AQUIRE, 1990). The committee reviewed available algal and acute aquatic invertebrate toxicity data and believes these data are insufficient because no EC~o values were reported. The Committee recommends ecological effects testing because there are insufficient data to reasonably determine or predict the ecological effects ofNN-dimethylaniline and because there are potentially substantial environmental releases. Ethyl Acetate Physical andChemicalInformation
CAS Number: 141-78-8 Synonyms and Trade Names: Acetic ether, acetic ester, vinegar naphtha.

Empirical Formula: C4 HOs Molecular Weight: 88.1 Physical State at 25* C: Liquid Description ofChemical: Clear, volatile, flammable liquid; characteristic fruity odor pleasant taste when diluted (Ref.164, Windholz et al., 1983].

Melting Point- -83.6*C(Ref.96, Lide, 1990)

Boiling Point: 77.1 (Ref.98, Lide, 1990) Vapor Pressure: 94.5mm Hg @ 25* C (Ref.2,Ambrose et al., 1981)

Specific Gravity: 0.898 (Ref.164, Windholz et al., 1983)

Log Octanol/Water Partition Coefficient: 0.73 (Ref. 68,Hansch and Leo, 1981)

Water Solubility at 25* C: 80,000 mg/L (Ref. 12, Banerjee, 1984)

Log I_: 0.94 (Ref. 100,Lyman et al., 1982) Henry's Constant: 1.38 X 10'4atm m 3 mole- (Ref.20, Bocek, 1976)
Rationale forRecommendations A. ExposureInformationProduction/use/disposal/exposure/ release. In 1988, 254.2 million pounds of ethyl acetate are produced in the United States (Ref.159, U.S. ITC, 1989). Ethyl acetate has the following uses: coatings-41 percent; exports-36 percent; solvent-13 percent; plastics--8 percent; chemical synthesis-2 percent (Ref.29, CMR, 1986). Many ofits solvent

uses include consumer products.

B. Evidence forexposure-Human exposure.The NOES survey estimated that419,180 workers (99,059 female)

were potentially exposed to ethyl acetate (Ref. 120, NIOSH, 1990). Of these workers, 87 percent were potentially exposed during the use of trade name products containing this compound. Potential exposure to ethyl acetate was associated with 34 different industrial classifications (Ref. 120,NIOSH, 1990). In addition, ethyl acetate is used as a solvent in numerous consumer applications. OSHA's PEL = 400 ppm 8- hour TWA; the Committee learned that Sweden may reduce their PEL to 150 ppm, but is unaware of the basis for this potential reduction.

Environmental exposure.Ethyl acetate was detected in66 samples obtained from 17 industries and POTWs at a maximum concentration of7.7 ppm (Ref. 138, Shackelford et al., 1983). Of 204 sites monitored in 14 heavily industrialized river basins in the U.S., ethyl acetate was detected at a concentration of 1ppb (Ref.51, Ewing et al., 1977). In a compilation of air monitoring data collected between 1970 and 1987, the median concentration of ethyl acetate in urban sites was 0.733 ppb (Ref. 139, Shah and Heyerdahl, 1988). Ethyl acetate was also detected in industrialized and urban sites in Virginia and West Virginia at concentrations ranging from <0.012 to 1.9 ppb (Ref.50, Erickson and Pellizzari, 1978). The STORET database indicates. that ethyl acetate has also been detected in groundwater (Ref. 148, STORET, 1990).

I.Chemical Fate Information

In the atmosphere, ethyl acetate appears to be susceptible to removal by oxidative processes (Ref.8, Atkinson, 1987; Ref. 28 CHEMFATE, 1990). The available data indicates that ethyl acetate's fate in water will be dominated by both rapid volatilization to the atmosphere (Ref. 100, Lyman et al., 1982) and rapid biodegradation (Ref. 18, BIODEG, 1990). Biodegradation is also likely to be a significant fate process in soil (Ref.18, BIODEG, 1990). Ethyl acetate should not significantly adsorb to soil (Ref. 100, Lyman et al., 1982). The Committee is not recommending chemical fate testing at this time. ,,,, 

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II. Health Effects Information

Ethyl acetate was readily absorbed following oral or inhalation administration to rabbits and rats, respectively, and was rapidly hydrolysed to ethanol and acetic acid (Ref. 150, Tambo, 1973; Ref. 58, Gallaher and Loomis, 1975). In a comprehensive 90-day gavage study in groups of30 male and 30 female Sprague-Dawley rats treated with ethyl acetate in corn oil at doses of300, 900 or 3,600 mg per kg per day, toxic effects resulting in reduced food intake and body weight, and altered organ weights were reported in high dose males; increased salivation, breathing changes and lethargy were also observed in high-dose groups (Ref. 156, U.S. EPA, 1986). Adverse effects on body weights, blood counts and urinalysis were not reported in a study in which 3guinea pigs were intermittently exposed by inhalation to 7,206 mg ethyl acetate vapors/ms for about 11 weeks (Ref. 143, Smyth and Smyth, 1928).

Data were not located regarding the developmental effects or reproductive toxicity ofethyl acetate.

Ethyl acetate was negative for induction ofreverse mutation in Salmonellawhen tested with (but not without) metabolic activation (Ref.80, Ishidate et al., 1984). Positive results

were observed for mitotic aneuploidy but negative results were observed for point mutations and recombination in yeast (Ref.167, Zimmerman et al., 1985). In mammalian test systems, a positive response was reported for chromosomal aberrations in Chinese hamster fibroblasts in vitro (Ref.80, Ishidate et al., 1984) and a negative response was reported for micronucleus formation in Chinese hamsters (Ref. 14, Basler, 1986). In vivo gene mutation testing may be necessary to characterize the mutagenicity ofNN-dimethylaniline.

Ethyl acetate was not a complete carcinogen when applied dermally (0.2 mL, 45 times during 23 weeks) to 8 female CD-1 mice (Ref.98, Lindenfelser et al., 1974). Ethyl acetate at doses of3.6

or 18 g/kg by intraperitoneal injection 3 times per week for a total of24 injections was negative in the Strain A

mouse lung tumor assay (Ref.147, Stoner et al., 1973). The mice were sacrificed 24 weeks afterthe first dose.

The Committee recognizes that NIOSH has Hazard Evaluation and Technical Assistance reports, etc. for ethyl acetate that are available from NTIS and the Committee is placing these documents in the public docket. The Committee recommends screening health effects testing and triggering oncogenicity testing because there are potentially substantial exposures, because there are insufficient data to reasonably determine or predict health effects and because these data are needed to reduce the uncertainty associated with risk assessments for ethyl acetate.
III. Ecological Effects Information

The Committee recognizes that acute LC values are available for 14 invertebrate species, 3 species of freshwater fish, freshwater algae, a salamander, and a toad. These data indicate that ethyl acetate is acutely toxic to aquatic fauna at concentrations ranging from 9 to < 1,000 mg/L (Ref.4, AQUIRE, 1990). The Committee is not recommending ecological effects testing at this time. 2,6-Dimethylphenol PhysicalandChemicalInformation

CAS Number: 576-26-1 Synonyms and Trade Names: 2,6-Xylenol Empirical Formula: CsHoO Molecular Weight: 122.2 Physical State at 250 C: Solid Description ofChemical: White crystalline solid (Ref.96, Lide, 1990)

Melting Point: 490 C (Ref.96,Lide, 1990) Boiling Point: 2120 C (Ref.96, Lide, 1990) Vapor Pressure: 0.15 mm Hg @ 200 C (Ref.163, Weber et al., 1981)

Log Octanol/Water Partition Coefficient: 2.36 (Ref.68, Hansch and Leo, 1981)

Water Solubility at 25' C: 96,000 mg/L (Ref.162, Wasik et al., 1981)

Log K: 1.45 [Ref. 100,Lyman et al., 1982) Henry's Constant: 7.5 X 107 atm m 3 mole " 1(Ref.100, Lyman et al., 1982) pK,: 10.59 (Ref.129,Pearce and Simkins, 1968)
Rationale forRecommendations A. ExposureInformationProduction/use/disposal/exposure! release.In 1977, between 2 and 20 million pounds of2,6-dimethylphenol

were produced at 6 different facilities in the United States (Ref.154, TSCAPP, 1990). There were 2 facilities that manufactured 2,6-dimethylphenol in the U.S. in 1989 (Ref. 145, SRI, 1989). Information on current production volumes is CBI, but production is substantial. It is used primarily in the production ofpoly(phenylene oxide) resins (Ref.52, Fiege, 1987). 2,6- Dimethylphenol is also used in the manufacture oftetramethylbisphenol A, 2,6-dimethylaniline, bis(4-hydroxy-2,5- dimethylphenyl)methane, dyes, pharmaceuticals and fragrances, and as
a mixture with other xylenols, in disinfectants, solvents, pharmaceuticals, insecticides, fungicides, plasticizers, rubber chemicals, lubricant and gasoline additives, and wetting agents (Ref. 136, Sax and Lewis, 1987). 

### B. Evidence forexposure-Human exposure.2,6-Dimethylphenol is used in

a variety ofcommercial applications, many ofwhich can lead to worker exposure. The NOES survey estimated that 1,941 workers (179 females) were potentially exposed to 2,6- dimethylphenol. Ofthese workers, 95 percent were potentially exposed during the use oftrade name products containing this compound.

Environmental exposure.2,6- Dimethylphenol was detected in 64 samples obtained from 33 industries and POTWs at a maximum concentration of 2,895 ppm (Ref. 138, Shackelford et al., 1983). In a compilation ofair monitoring data collected between 1970 and 1987, the mean concentration of2,6- dimethylphenol in source dominated

areas was reported as 0.080 ppb (Ref. 139, Shah andHeyerdahl, 1988). The
mean concentration of2,6- dimethylphenol in the air ofPortland, OR, during 7rain events in 1984 was 2.2 ppt,while the concentration of2,6- dimethylphenol in the rain ranged from 84 to 280 ng/L (Ref.93, Leuenberger et 

### al., 1985). 2,6-Dimethylphenol was detected in shale oil wastewater in the range 0.75 to 1.7 pg/L (Ref. 71, 

### Hawthorne and Sievers, 1984) and at 12 mg/L in the wastewater from the gasification ofcoal (Ref.59, Giabbi et al., 1985). It was detected in groundwater samples from a wood preserving facility in Florida at a concentration of0.90 mg/L, while the concentration of2,6-dimethylphenol 330

m from the site was 0.29 mg/L (Ref.61, Goerlitz et al., 1985).
I. Chemical Fate Information

Atmospheric degradation by photochemically produced hydroxyl radicals should rapidly remove 2,6- dimethylphenol in sunlight (Ref.10, Atkinson, 1987); degradation at night should be more rapid in urban areas through the reaction with nitrate radicals (Ref.25, Carter, 1981). Rain washout is expected to be an effective method ofatmospheric removal for2,6- dimethylphenol (Ref.93, Leuenberger et al, 1985). Limited data are available on the fate of2,6-dimethylphenol inwater. Volatilization from water is not expected to be a significant removal process based on the Henry's Law constant (Ref.100, Lyman et al, 1982]. In humic waters, reaction with alkyl peroxy radicals should occur (Ref.110, 

### Mill, 1982); however, no chemical specific data are available. Screening studies suggests that 2,6-dimethylphenol biodegrades fast under aerobic conditions after acclimation (Ref.18, BIODEG, 1990); however,data are 9557

### Federal Register / Vol. 56, No. 44 / Wednesday, March 6, 1991 / Notices

limited and no studies ofthe degradation of2,6-dimethylphenol in environmental samples are available. Under anaerobic conditions, one screening study indicates that 2,6- dimethylphenol is not expected to biodegrade (Ref.18, BIODEG, 1990). Aqueous photolysis rate estimates and biodegradation data are probably inadequate to determine photolysis and biodegradation rates of2,6- dimethylphenol in the environment, because the estimates and data were not generated using test systems that simulate in situprocesses. The Committee recommends chemical fate testing because there are insufficient data to reasonably determine orpredict the persistence of2,6-dimethylphenol and because there are potentially substantial environmental releases. II. Health Effects Information

In 2reports ofan 8-month rat gavage study, histopathological changes in the liver, spleen and kidneys and changes in body weight,blood pressure and levels of protein sulfhydryl groups in blood

serum and internal organs were observed in 53 male rats treated with 6 mg per kgper day (Ref.160, Veldre and Janes, 1979and Ref. 101, Maazik, 1968). Effects were not seen in rats dosed with 0.6 

### mg per kgper day. Increased relative liver and spleen weights, decreased body weightgain and marked atrophy and parenchymatous dystrophy ofliver cells were observed in 10 male albino rats treated by gavage with 29.5 mgper kg perday for 10 weeks (Ref.101, Maazik, 19687).



### Data on the developmental toxicity or reproductive effects of 2,6- dimethylphenol were not located.

Oncogenicity data were limited to a dermal study that identified 2,6- dimethylphenol as a weak promoter in the two-stage mouse skin assay (Ref.21, Boutwell and Bosch, 1959). In this study, 30 female Sutter mice were treated with
an initial 75jg application of dimethylbenzanthracene followed by 25 fL of20 percent 2,6-dimethylphenol in benzene for 15 weeks.The mice were sacrificed at23 weeks. In a second part ofthis study, 25 pL of10 percent 2,6- dimethylphenol was applied twice weekly for 20 weeks to mice thathad not been initiated with dimethylbenzanthracene and the mice
were maintained for an additional 8 weeks. There were "minimal effects" indicating carcinogenicity.

Mutagenicity testing of2,6- dimethylphenol was limited to a single study inwhich the compound was negative with and without metabolic activation in the reverse mutation test in 4 strains ofSalmonella(Ref.54, Florin et al., 1980). Additional testing in nonbacterial systems may be necessary to characterize the mutagenicity of2,6- dimethylphenol.

The Committee recommends screening health effects testing because there are potentially substantial exposures, because there are insufficient data to reasonably determine or predict health effects and because these data

are needed to reduce the uncertainty associated with risk assessments for 2,6- dimethylphenol.
III. Ecological Effects Information

Acute aquatic toxicity studies are available for green algae, duckweed, daphnids, sea urchins, fathead minnows and Atlantic cod, and one chronic study is available for the fathead minnow (Ref.4, AQUIRE, 1990). Available algal toxicity data are probably insufficient because no ECso values were reported. Available fish chronic toxicity data are probably insufficient because they do not provide information on the effects of 2,6-dimethylphenol to sensitive fish life stages. The Committee recommends additional ecological effects testing because there are insufficient data to reasonably determine or predict the ecological effects of2,6-dimethylphenol and because there are substantially potential environmental releases.
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(109) Mill, T., Hendry, D.G., and Richardson, H. "Free radical oxidants in natural waters." Science. 207: 886-887 (1980).

(110) Mill, T.Hydrolysis and Oxidation Processes in the Environment. Environmental andToxicologicalChemistry.135-41. (1982).

(111) Miller, J.J., Powell, G.M., Olavesen, A.H., and Curtis, C.G. "The toxicity of dimethoxyphenol and related compounds in the cat." Toxicology and Applied Pharmacology. 38: 47-57 (1976). (112) Miller, R.R., Ayres, J.A., and Jersey, G.C. "Acrylic acid 10-day vapor inhalation study with rats and mice, final report." #79RC-1015. Toxicology and Research Laboratory, Health and Environmental Science, Dow Chemical Company, Midland, MI. (1979).

(113) Miller, R.R., Ayres, J.A., and Jersey, G.C. "Acrylic acid 90-day vapor inhalation study with rats and mice, final report." #79RC-1024. Toxicology and Research Laboratory, Health and Environmental Science, Dow Chemical Company, Midland, MI. (1979).

(114) Miller, R.RI,Ayres, J.A., Jersey, G.C., and McKenna, M.J. "Inhalation toxicicty of acrylic acid." Fundamental and Applied Toxicology. 1(3): 271-277 (1981).

( (115) Moore, M.M., Amtower, A., Doerr, C.L., Brock, K.H., and Dearfield, K.L. "Genotoxicity of acrylic acid, methyl acrylate, ethyl acrylate, methyl methacrylate, and ethyl methacrylate in L5178Y mouse lymphoma cells.Environmentaland MolecularMutagenesis.11:49-63 (1988).

(116)NCI (National Cancer Institute). Bioassasy ofphenol for possible carcinogenicty in F344 rats and B6C3F1 mice. NIlH Publication No. 80-1759 (1980).

(117) Niemi, G.J., Veith, G.D., Regal, R.R., and Vaishnav, D.D. "Structural features associated with degradable and persistent chemicals." EnvironmentalToxicologyand Chemistry.6:515-527 (1987).

(118) Nelson, C.R., and Hites, R.A. "Aromatic amines in and near the Buffalo River." Environmental Science and Technology. 14(9): 1147-1149 (1980).

(119) Nicola. R.M., Branchflower, R., and Pierce, D. "Chemical contaminants in bottomfish." Journalof Environmental Health.49(6): 342-347 (1987).

(120) NIOSH (National Institute for Occupational Safety and Health). National Occupational Exposure Survey (NOES) (1990).

(121) NTP (National Toxicology Program). Teratologic evaluation ofphenol in CD rats 

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and mice.Prepared by Research Triangle Institute. Research Triangle Park, NC.NTIDS PB83-247726. Gay. Rep. Announce. Indem 83(25): 6247 (1983).

(122) NrP (NationalToxicology Program). Toxicology a"dcarcinogenesis studies of parachloroanibne-hydochlride in.F344/N rats and BDC3F1 mice. " Technical Report No. 351. U.S. Departmeit ofHealth and Human Services. Public Health Service, National Institute ofHeath, Research Triangle Park, NC.('189]

(123) Odenbro, A., ad'Arrhenius, E. "Effect oftriethy? lead chloride on hepatic microsomai N-oxygowtim and Coxygenation of N,Ndimethylaniline inrats." Toxicologyand Applied Phiwnacology.74(3p. 357-363 (1984].

(124) Ohmiya, Y., and Mehendale, H.M. "NOxidation of,Xdimethyfanirilinein the rabbit and rat lung." Biochemical, Pharmacology. 32(7): 1281-1265 (1983). (125) Olasoos U., Baije. &. Wachtmeister, C.A., and- Arrhenhia, E."Effects of dimethylnitrosoamint on metabolism ofNNVdimethylaniline by rat liver microsomes. A comparative study oftreatment in,vivo in isolated liver perfusion and in the micresomal system." Chenmeo-Biolbgiaol Interocti"om.45(2 191-M!1 ('I93).

(126) Olaon. U..Onfiet, A.. andBeije, B. "Dietary selenium deficiency causes decreased Noxygenation ofAXNdimethylaniline andincreased mutagenicity of dimethylnitrosoamine in the isolated rat liver/cell culture system."'Mutotion Research. 126{8()73-80 (841. (1271) Pahrem HIL. antBla ood, 11E. "Biologt g oxidto. ofseveral vinyl compounds." WaierPathiatnControl Federotioa Joun 33 233-238 (1961. (12a)PCGEMS3. Graphical Exposure Modeling System (GEMS)- CLOGP. U.S. EPA (1987).

(129tPearce, P... and Simkins, R.J.J. "Acid strengths ofsome substituted picric acids." CandionJoarnal sfChemispy.4t 241-246 (19.

(33a Perry, R.H, and Green, D.Perry's Chemical Handbook. B.aditiaem.New York. NY. McGraw-Hill (19a4).

(131] PicciriflI. V.J, McCall, D.L, Lunchick, C., Plankenhom. L..,andSexsmith, C. Screening ofprioritychemicals for reproductive hazards. NTIS PB8a-257800. p. 108 (1963].

(13) Pini A.]. and Boring.. KJEB "Selective degeneratio. intherat olfactory bulb follewing exposure to different odours." BrainBesearch82(4195-204 (1974),

(133) Rana, A. "A;-Oxidation ofa tertiary amine (VMN-dimethylanillne) by human fetal liver microsomes." ChnicalPharmacology andTherapeutics.3Mf): 32-8(1974).

(134) F6delcc. J.A., RBuner, W.B., and Sakaw, T " Organic Solvents: Physical Properties and Methods al Purification. Techniques oi Chemfatr SerlsL4th edition. New York. NY: Wiley--lnterscience. 3:355-356. 64Q-641(C98a..

f "35) Sandage, C. "Tolerance criteria for continuous inhalation exposure to toxic mateia"'ASD Tkchnicatiteparez-6759 (1), Kansas City, rAQ Mdkkwest Research Institute. W. 1-29 119061.

(136 Sex.,NJ- and Lewis, B.] Haweley's Condensed Chemical Dictionary.lith edition. New York. NY: Van Nostrand Reinhold Company. pp. 910,411, 421, 896-897, 1244 (1987).

(137) Serjeatt.E.P and Dempsey, B. "Ionization constats of organic acids in aqueous solution." JUPAC Chemical Data SeriesNa.33. New York, NY: Pergamon Press. pp, 160-101 (1979J.

(138) Shackelford, W.M., Cline, D.M., Fass, L., and Kurth. G. "An evaluation of automated spectrum matching for survey identification ofwastewater components by gas chromatography-mass spectrometry." Anolytica Chemica Act. 146: 15271 [supplemental datal (1983),

(139] S , .1, and Heyerdhl, E.KL Nationalambinet volatileorganic compounds. (VOCS])database update. EPA/60G-3-88-010. p. 48 (1988).

(140] Singh, A.R., Lawrence, W.H, and Autian,.J "Embryonic-fetal texicicty and teratogenic effcts ofa group ofmethecrylate esters imrats" louinaof DentaLResearch. 51(6]: 1632-M 81197Z).

(141) Smith, .N. Smithies, RI-., and Williams, R.T. "Studies in,detoxication 56. The metabolism ofalkylbenzenes. Stereochemical aspects of the.biological hydroxylation ofethylbenzene to methylphenyltarbinol" Blochemical ourna. 56: 320-,24(19541,

(142) Smyth, 1.; "'Acuteand sub-acuate, toxicity of acetophenane' Report -41 Mellon Instiute ofInd.Res. 11046.

(1431 Smyth; iLF., and Smyth, RF., ip. "Inhalation experiments'with certain lacquer solvents." Journalof IndustrialfHygiene and Toxicology. 10"261-271 (1928.

(144) Sontheimer, H., Bauch,H.f., and Kuhn, W. "Impact ofdifferent types of organic micropolutents present on sources of drinking water on the quality ofdrinking water." Scienceofthe Total urrionmen.L47: 27-44[1965).

(14S) SRI (SRI International}, Directory of Chemical Producers. Menlo Park. CA. SRI InternationaL pp. 844,-WS. 1063 (1989),

(1461 Staples, C, Werner, A., and' Hoogheem, T "Assessment ofpriority pollutant concentrations in the United States using STORETdatabase." Enirenmental Toxicology andChemistry 4:131-142 (185).

(1471 Stoner GD. Shimkin.M.B. Kniazeff, A.J., Weisburgjr; ].H..Weisburger, EK., and Cori. G. "Test'for carcinogenicity offood additives and chemotherapeutic agentsby the pulmonary tumor response instrainA mice"'CancerResearch.33' 3069-385 (1973).

(148)STORET. STORET Data Base retrieval 3/19/1'.Washfington, DC: U.S. EPA. (1990).

(149) Suet I.H, Brenner.L.and Cairo. P.. "Gas chromatgraphy nmoas spectrometry identificaton oftrace.organics in Philadelphia, Pennsylvania, USA drinking waters during a twayear period." Water Research. 14:853-867 1980).

(T50) Thmbo.S. "Toxicity hazards ofpaint thinners with particularemphasis on the metabolism and toxicity of'acetate esters." Nichido ':zkvwZbsh 32f3). 340-360 (1973).

(151) Thierfaldet. K- and Deiler, IK"Zur kenntala des verhaftens fettaromtischer ketone im tferkorper." Hoppe Seyier's ZeitscAift fuerPhysialogische Chemie. 13e. 380-396 (1923. (152) Thierfelderj K., and Klenk, E. "Zur kenntnis,des verhaltens des acetophenons und benzols im tierkorper." -ippe Seyler's Zeltschrift fuer Physiologische Chemie. 141: 2932 (19241.

(153] TRI (Toxics Release Inventory. Database retrieval 3/10/W.U.S. EPA. (19901.

(154] TSCAPP. Computer print-out of nonconfidential production data from TSCA inventory. Washington, DC: OTS, CID, U.S, EPA. Online 3'/1/90 (1990),

(155] Uehieke, H.. Reiner, 0. and Hellmer,, K.H. "Perinatal development ofteriary amine Noxidation and NADPH cytochrome c reduction In ratliver microsomes." Research Communicationsin Chemical Proitlogy and' Pharmaclogy. 2J"M9880 (f971]. (156) U.S. EPA.."Ratorat subchronic study with ethyt acetate.' Washington, DC: Office ofSolid Waste, U.S. Environmental Protection Agency (1986].

(157) U.S. EPA. Health and Environmental Effects Document for Acetophenone. Prepared for the Environmental Criteria and Assessment Office, US. EPA, Cincinnati, Off. (1987).

(1W) U.S. rIC (U. ilaernational Trade Commission. Synthetic Organi Chemicals. U.S, Production and Sale. 1979. Washington. DC: U.S. Goverment Printing OfficePublication No. 1099.p 43(19801.

(159JUS. r (U.S. International Trade Commission. Synthetic OrganicChemicals. U.S. Production and Sales 1988. Washington, DC. U.S. Government PrintingOffice. PublicationNo.21 pp. 3-12,15-4, and15-6 (198).

(160) Veldr, LA., andlanes, H.] "Toxicological studies ofshale oils, some of their components and commerciaL products." Environmental HealthPerspectives. 30: 141- 146 (1979].

(161] Walker; tD. "Relative sensitivity of algae, bacteria, invertebrates, andfish to phenol: Analysis of234tests conducted for
more than 149Specie." Thidcity Astiesrment:., An LoteratdoalJomrnaL 3.4T5- 457 (IC88).

(162] Wasik, S.PTewariY.., Miller, M.M.,andMatire, .E. "Octanol/water partition coefficients and aqueous sorubities oforganiccompounds." NBSIRSt-2406. Washington, DO. U.S, Department Cbmm Nati. Bur. Sid. (1.

(163) Weber, R.C., Parker, P.A., and Bowser, NlVapor Pressure Distribution of Selected Organic Chemicals. EPA,-600/2.1- 021. CincinnatiOH: U.S. EPA. (1981),

1164] Windholz, M.Budavarf, S:.Blumetf, R.F., and Otterbein, E.S., The Merck Index. l0th edition.Rahway, New Jersey: Merck Co., Inc.. pp,19% 478-47 545, M (1983J. (105)Wise E.E., and Fahrentlid P.IX "Occurrence andpredictility a peiority pollutants in wastawaters of theorplnic chemicals and plastica/synthetic fibers industrialcategories." American Chemical Society. 181st National Meeting,,Division of Industrial Chemical Symposimaon Treatability ofIndustrial AqueousEfflents. (1981).

(166)Ziegler; D.M. andGbld.M.& "Oxidatlvemetabolism of tertiary amine, drugs by,human andliver tissue' Zenobiotica.1: 325326 (1971]. 

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(167) Zimmermann, F.K., Mayer,V.W., ScheeL I., and Resnik, M.A. "Acetone, methyl ethyl ketone, ethylacetate, acetonitrile and other polar aprotic solvents are stgrong inducers of aneuploidy inSaccharomyces cerevisiae."MutationResearch.149: 339-351 (1985).

2.3Recommended with intent-todesignatechemicals-2.3.aAldehydes. The aldehyde group was nominated to the Committee by EPA for aquatic toxicity testing.The Committee's computerized substructure-based selection processes were used to identify individual chemicals in the aldehyde group. Two aldehydes, crotonaldehyde (CAS # 4170-30-3) and butyraldehyde (CAS # 123-72--8) were previously recommended in the 22nd and 23rd reports, respectively. Two aldehydes, isobutyraldehyde (CAS # 78-84-2) and propanal (CAS # 123-38-6)
are among the 53 chemicals in the Organization for Economic Cooperation and Development's (OECD) Screening Information Data Sets (SIDS) phase one voluntary testing program. Submission of reliable data or data development through the voluntary OECD SIDS program could change the Committee's testing recommendations for these two aldehydes. Two of the recommended aldehydes, acetaldehyde (CAS 75-07-0) and propanal were listed among the chemicals in Title III ofthe 1990 amendments ofthe Clean Air Act that the Committee is continuing to review. The Committee's recommendation of aldehydes is consistent with its comprehensive approach to processing Member Agency chemical groups and identifying substructure-based chemical groups In need of testing. Other chemical-group based actions include groups such as brominated flame retardants recommended in the 25th report and alkyl phosphates and isocyanates recommended in the 26th report.

The TSCA Inventory names are used in the paragraph following Table 1. These names are used to facilitate comparison with the names in the TSCA section 8(a) and 8(d) rules that EPA will prepare for chemicals recommended in this Report. Since common names of aldehydes are used in this chapter, the CAS number is listed in parentheses following the first use of a common. name to facilitate identification of chemicals listed in the paragraph following Table 1.

Summaryofrecommendedstudies. Testing recommendations for the aldehydes listed in the paragraph following Table Iare summarized in Table 1. Physical andChemicalInformation The physical and chemical properties of the very large volume aldehydes listed in the paragraph following Table 1
are well described in the literature. The Committee, however, was unable to identify the physicaland chemicals properties of environmental and health significance for all members of this group. Rationale forRecommendation
A. ExposureInformationProduction/use/disposal/exposure! release. The Committee believes that the aldehydes listed in the paragraph following Table 1 are commercially available, and that many are produced in substantial quantities. For example, acetaldehyde, Isobutyraldehyde, and propanal have current domestic production capacities exceeding 300 million pounds (Ref. 22, SRI, 1990). Actual production volumes ofthe other aldehydes are CBI.

Aldehydes are used primarily as synthetic intermediates, yet aldehydes
are also used in significant quantities in applications that are expected to result in both human and environmental exposure. Aldehydes are used in the production of alcohols, carboxylic acids, agricultural chemicals, pharmaceuticals, disinfectants,dyes, detergents, food additives, catalysts for crosslinking polymers, and fragrance chemicals (Ref. 5, Falbe et al., 1985; Ref.21, Sherman, 1978). Acetaldehyde, propanal, and acrolein (CAS 107-02-8) have particular importance in commercial applications.

Many members of the aldehydes listed in the paragraph following Table 1
are used in fragrances and flavors. For example, a-pentylcinnamaldehyde (CAS 122-40-7) is a popular perfume in soaps, the C-Cia saturated alkyl aldehydes are used as fragrances and toning agents (Ref. 5,Falbe et al., 1985), and 4- methylphenylacetaldehyde (CAS 99-72- 9), vanillin (CAS 121-33-5), and piperonal (CAS 120-57-0) are used in flavors (Ref.5, Falbe et al., 1985; Ref. 19, Sax and Lewis, 1987). Piperonal is used in suntan and mosquito repellents and citronellal (CAS 106-23-0) is used in insect repellents (Ref.19, Sax and Lewis, 1987). The Committee, therefore, is concerned with the potential for release and exposure resulting from the high production volumes and numerous uses ofthe various members of this group.

B.Evidence forexposure--Human exposure.There is an extensive data base relating aldehydes to human exposure. For example, acetaldehyde, isobutyraldehyde, propanal, furfural (CAS 98-01-1), and benzaldehyde have been found in U.S. drinkingwater supplies (Ref.2, Coleman et al., 1976; Ref.9, Keith et al., 1976; Ref. 11, Krasner et al. 1989; Ref. 10, Kool et al., 1982; Ref. 12, Lucas, 1984). Benzaldehyde, nonanal, and dodecanal have been found in breath, personal air, ortap water samples (Ref. 26, Wallace et al., 1984). Acetaldehyde, isobutyraldehyde, butyraldehyde, methylbutyraldehyde (CAS 590-86-3), valeraldehyde (CAS 110-62-3), furfural, heptanal, benzaldehyde, octanal, decanal, undecanal, and dodecanal have been identified in samples of human mothers' milk (Ref. 18, Pellizzari et al., 1982).

The NOES conducted during 1981-83 by NIOSH reported that 14,054workers
were potentially exposed to acetaldehyde; 28 to trichloroacetaldehyde (CAS 75-87-6); 4113 to isobutyraldehyde; 22,173 to 4-(1,1-dimethylethyl)-a-methylbenzenepropanal (CAS 80-54-6); 2,187 to 1,3,3-trimethyl-2- (formylmethylene)indoline (CAS 84-83- 3); 4,598 to salicylaldehyde (CAS 90-02- 8); 34 to 2,5-dimethoxybenzaldehyde (CAS 93-02-7); 1,557 to amethylbenzeneacetaldehyde (93-53-8); 134,158 to furfural; 17,271 to4- (dimethylamino)benzaldehyde (CAS 100-10-7); 30,517 to benzaldehyde; 23,972 to 2-(phenylmethylene)-octanal (CAS 101-86-0); 44,721 to a-methyl-4-(1- methylethyl)benzenepropanal (CAS 103- 95-7); 62,450to 3-phenyl-2-propenal (CAS 104-55-2); 12,494to p-tolualdehyde (CAS 104-87-0); 6,573 topchlorobenzaldehyde (CAS 104-88-1); 2,162to citronellal; 1,300 to acrolein; 42,978 to ethanedial; 10,938 to 7- hydroxy-3,7-dimethyloctanal (CAS 107- 75-5); 1,863 to 2-methylundecanal (CAS 110-41-8); 1,557 to pentanal; 350,626 to pentanedial; 21,760to heptanal; 20,732 to decanal; 1,557 to undecanal; 1,650 to 10- undecenal; 7,056 to dodecanal; 72 to veratraldehyde (CAS 120-14-9); 1,450 to 4-(diethylamino)benzaldehyde (CAS 120-21-8); 15,846to piperonal; 18,034 to 3-ethoxy-4-hydroxybenzaldehyde (CAS 121-32-4); 65,750to vanillin; 14,182to 2- (phenylmethylene)heptanal (CAS 122- 40-7); 868 to phenylacetaldehyde (CAS 122-78-1); 43,899to p-anisaldehyde 

### (CAS 123-11-5); 2,087 to propanal; 12,959 to octanal; 7,149 to nonanal; 3,433 to hexahydrodibenzofurancarboxaldehyde (CAS 126-15-5); 5,331 to 2- nitrobenzaldehyde (CAS 552-89-6); 1,557 to a-pentylcinnamaldehyde; and 28 to methylbenzaldehyde (CAS 1334-78-7) (Ref.17, NIOSH, 1989).

Environmental Exposure.According to the TRI, 9,466,569 pounds of acetaldehyde were released to the environment In 1988 (Ref.24, TRI, 1990). Corresponding releases for other 

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members ofthe aldehydes group listed in TRI are as follows: propanal: 1,048,296 

### pounds: isobutyraldehyde: 791,996 pounds and acrolein: 103,068 pounds (Ref. 24, TRI, 1990). A compilation of published and unpublished data on the atmospheric concentration ofvolatile organic compounds determined between 1970 to 1987 found that acetaldehyde, benzaldehyde, 2-propenal, propanal, and methylbenzaldehyde have been detected in remote, rural, suburban, urban, source dominated, indoor, or workplace air samples (Ref. 20, Shah and Heyerdahl, 1988).

Members ofthe aldehyde group have been detected in various environmental samples. For example, acetaldehyde, ethanedial, acrolein, propanal, benzaldehyde, and valeraldehyde have been detected in rain and/or fog samples (Ref.7,Grosjean and Wright, 1983; Ref. 13, Mazurek and Simoneit, 1986; Ref. 23, Steinberg and Kaplan, 1984). Isobutyraldehyde, furfural, and benzaldehyde were detected in surface water samples obtained from 204 sites in the United States near heavily industrialized areas (Ref.4,Ewing et al., 1977). Isobutyraldehyde and propanal
were listed as frequently detected organics in the U.S. National Organics Reconnaissance Survey of surface waters (Ref.6, Fielding and Packham, 1977). Acetaldehyde, propanal, 

### ethanedial, heptanal, octanal, nonanal, decanal, undecanal, and dodecanal have been detected in seawater samples (Ref. 8, Gschwend etal., 1982;Ref. 15, Mopper and Stahovic, 1986]; although acetaldehyde, propanal, and ethanedial may arise from natural as well as industrial sources (Ref. 15, Mopper and Stahovic, 1986). Isobutyraldehyde has been detected in the Delaware River (Ref.3,DeWalle and Chian, 1978), and benzaldehyde has been detected in samples from freshwater lakes (Ref. 14, McFall et al., 1985). Benzaldehyde and 4- (dimethylamino)benzaldehyde have been detected in soil samples taken near the Buffalo River (Ref.16; Nelson and Hites, 1980). I.Chemical Fate Information

Chemical fate testing for the aldehydes is not recommended at this time. II.Health Effects Information

Health effects testing for the aldehydes is not recommended at this time. III. Ecological Effects Information

Structure-activity relationships (SAR)
are frequently used to predict the toxic potential ofuntested chemicals when assessing theirpotential for adverse ecological effects (Ref.1, Auer et al. 1990). The Committee previously used SAR to identify the toxic potential of 2,6-di-tert-butylphenol in the 17th report. SARs used as part ofthe Committee's computerized, substructure-based chemical selection processes suggested that aldehydes could be toxic to birds, fish and mammals (Ref.25, Walker and Brink, 1989). SARs have suggested that aldehydes could have excess toxicity 

### (Ref. 1, Auer et al. 1990). Chemicals that could have excess toxicity are those that could be more toxic than would be predicted for neutral organics based on
a narcotic mode of action. The Committee is concerned that SARs for aldehydes are only available to predict acute toxicity to fish.The Committee recommends ecological effects testing because there are potentially substantial environmental releases and because there are insufficient data to reasonably determine or predict the ecological effects ofaldehydes that are submitted to the EPA as new chemicals.
References

(1)Auer, C.M., Nabholz, J.V., and Baetcke, K.P. "Mode ofaction and theassessment of chemical hazards in thepresence oflimited data: Use ofstructure-activity relationships (SAR) under TSCA, Section 5." Environmental HealthPerspectives87:183- 197 (1990).

(2) Coleman, W.E., Lingg. R.D., Melton, R.G. and Kopfler, F.C. "The occurrence ofvolatile organics in five drinking water supplies using gas chromatography/mass spectrometry." In: AnalysisandIdentificationofOrganic Compoundsin Water.L. Keith, Ed. Ann Arbor Science, Ann Arbor, MI. 305-327 (1976).

(3) DeWalle, F.B. and Chian,E.S.K. "Presence of trace organics in the Delaware River and their discharge by municipal and industrial sources." Proceedings ofthe IndustrialWaste Conference.32:908-919 (1978).

(4) Ewing, B.B., Chian, E.S.K., Cook, J.C., Evans, C.A., Hopke, P.K. and Perkins, E.G. "Monitoring to detect previously unrecognized pollutants in surface waters." U.S.Environmental Protection Agency, Washington, D.C. EPA-560/677-015 (1977).

(5)Falbe, J., Henkel, K.G., Dusseldorf,P.L. and Weber, Jurgen. "Aldehydes, aliphatic and araliphatic." In: Ullmann'sEncyclopedia of

IndustrialChemistry,5th Edition. W. Gerhartz, Y.S. Yamamoto, Eds. VCH Publishers, Deerfield Beach, FL. A1:321-352 (1985).

(6)

Fielding, M. and Packham, R.F. "Organic compounds indrinking water and public health." Journalof InstitutionalWaterand Engineering Science. 31:353-375 (1977). (7) Grosjean, D. and Wright, B. "Carbonyls in urban fog, ice fog, cloudwater and rainwater." AtmosphericEnvironment. 17:2093-2096 (1983).

(8) Gschwend, P.M., Zafiriou, O.C., Mantoura, R.F.C., Schwarzenbach, R.P. and Cagosian, R.B. "Volatile organic compounds at a coastal site. 1.Seasonal variations." Environmental Science andTechnology. 16:31-38 (1982).

(9] Keith, L.H., Garrison, A.W., Allen, F.R., Carter, M.H., Floyd, T. L., Pope, ).D.and Thruston, A.D. "Identification oforganic compounds in drinking water from thirteen U.S. cities." In:IdentificationandAnalysisof Organic Pollutantsin Water.L.H. Keith, Ed. Ann Arbor Press, Ann Arbor,MI. 329-373 (1976).

(10) Kool, H.J., Van Kreijl, C.F. and Zoetman, B.C.J. "Toxicology assessment of organic compounds in drinking water." Critical Reviews inEnvironmentalControl. 12:307-357 (1982).

(11) Krasner, S.W., McGuire, M.J., Jacangelo, J.G., Patania, N.L, Reagan, K.M. and Aieta, E.M. "The occurrence of disinfection byproducts inU.S. drinking water." JournaloftheAmerican Water WorksAssociation.81:41-53 (1989).

(12] Lucas, S.V. "GC/MS analysis of organics in drinking water concentrates and advanced waste treatment concentrates." Health Effects Research Lab, Columbus, OH. EPA-600/184-020A. 1:133-162 (1984).

(13) Mazurek, M.A. and Simoneit, B.R.T. "Organic components in bulk and wet-only precipitation." CRCCritical Reviews of Environmental Control.CRC Press, Inc.Boca Rotan, FL. (1986).

(14) McFall, J.A., Antoine, S.R. and Deleon,
I.R. "Organics in the water column ofLake Pontchartrain." Chemosphere. 14:1253-1265 (1985].

(15] Mopper,K and Stahovic, W.L. "Sources and sinks oflow molecular weight organic carbonyl compounds in seawater." Marine Chemistry.19:305-323 (1986).

(16) Nelson, C.R. and Hites, R.A. "Aromatic amines in and near the Buffalo River." Environmental Science andTechnology. 14:11471149 (1980).

(17] NIOSH. Department ofNational Industrial and Occupational Safety and Health, National Occupational Exposure Survey (NOES). (1989).

(18) Pellizzari, E.D., Hartwell, T.D., Harris, B.S.H., Waddell, R.D., Whitaker, D.A. and Erickson, M.D. "Purgeable organic compounds in mother's milk." Bulletinof Environmental Contaminationand Toxicology.28:322-328 (1982).

(19) Sax N.I. and Lewis R.J.S.R. "Hawley's Condensed Chemical Dictionary, 11th ed." Van Nostrand Reinhold Co., New York, NY. pp. 922 and 1217 (1987).

(20) Shah, J.J. and Heyerdahl, E.K. "National ambient volatile organic compounds (VOCs) database update". U.S. Environmental Protection Agency, Washington, DC. EPA/600/388/010. pp.44-73 (1988).

(21) Sherman, P.D. "Butyraldehyde." In: Kirk-OthmerEncyclopediaofChemical Technology,Third Edition. John Wiley and Sons, New York, NY. 4:790-798 (1978).

(22) SRI International. "Directory of Chemical Producers." SRI International, Menlo Park, CA. (1990).

(23) Steinberg, S. and Kaplan, I.R. "The determination oflow molecular weight aldehydes in rain, fog, and mist by reversed phase liquid chromatography ofthe 2,4-

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dinitrophenyihydrazone derivatives." International Journalof Environmental AnalyticalChemistry.18:723-726 (1984).

(24) TRI. Computerprintout of the Toxics Release Inventory. (1990).

(25) Walker. J.D., and Brink, R.H. "New cost-effective, computerized approaches to selecting chemicals for priority testing consideration." Aquatic Toxicology and Environmental Fate. G.W. Suter IIand M.A. Lewis, eds. American Society forTesting and Materials, Philadelphia, PA. ASTM STP 1007. 11:507-536 (1989).

(26) Wallace, L.A., Pellizzari, E., Hartwell, T., Rosenzweig, M., Erickson, M., Sparacino, C.and Zelon, H. "Personal exposure to volatile organic compounds. I.Direct measurements inbreathing-zone air, drinking water, food,and exhaled breath." Environmental Research.35,293-319 (1984). 2.4Recommendedchemicals-2.4.a IRIS Chemicals-Summaryof recommendedstudies.Recommended studies are summarized in Table 1. 2,4-Dinitrophenol Physical andChemical Information
CAS Number. 51-28-5 Synonyms and Trade Names: 1-hydroxy- 2,4-dinitrobenzene (or 2,4-DNP)

Empirical Formula: CH4 N20 Molecular Weight: 184 Physical State at 25* C Solid Description ofChemical: Light yellow crystals (Ref.62, Windholz et al., 1983

Melting Point: 1130 C(Ref.62, Windholz et al., 1983)

Boiling Point Sublimes (Ref.34, Lide, 1990)

Vapor Pressure: 5.1 X O mm Hg @20 ° C (Ref.47, Schwarzenbach et al., 1988)

Specific Gravity: 1.683 (Ref.34. Lide, 1990) Log Octanol/Water Partition Coefficient: 1.54 (Ref.25,Hansch and Leo, 1981)

Water Solubility at 200 C: 2,787 mg/L (Ref. 47, Schwarzenbach et al 1988)

Log Koc. 1.75 (Ref.36, Lyman at al., 1982) Henry's Constant: 4.43 X 10'atm m' mole " (Ref.36, Lyman etal., 1982)

pK.: 4.09 (Ref. 23, Gordon and Ford, 1972)
Rationale forRecommendations A. ExposureInformationProduction/use/disposal/exposure! release. The production volume of 2,4- dinitrophenol is CBI, but current production is substantial. 2,4- Dinitrophenol is used in the synthesis of dyes, picric acid,picaramic acid, wood preservatives, diaminophenol dihydrochloride (a photographic developer), explosives, insecticides, and

as a pH indicator (Ref. 46, Sax and Lewis, 1987; Ref. 62, Windholz et al.. 1983). Z,4-Diitrophenol may also be formed in the atmosphere by the reaction ofnitrate radicals with phenol

or other aromatic compounds.

B. Evidence forexposure-Human exposure.Few data were located. ATSDR believes that 2,4-dinitrophenol may have been present in eight superfund sites.Eckel et al. (Ref. 16, 1986) reported an average concentration of 1,312 + 2,519 ppm 2,4-dinitrophenol for four hazardous waste dumpsite samples. The substantial production volume and uses in a variety of applications suggest significant occupational exposure potential.

Environmental exposure.2,4- Dinitrophenol was detected in 21 samples obtained from 8industries and POTWs at a maximum concentration of 10.2 ppm (Ref.49, Shackelford et al., 1983). The STORET database indicates that 2,4-dinitrophenol was foundin 2 percent ofindustrial effluent samples monitored between 1980 and 1983, and 0.4 percent ofthe ambient water samples (Ref. 52, Staples et al., 1985). According to TRI, the total release of 2,4-dinitrophenol to the air in 1987 was 32,600 lbs, while 86,500 lbs and 750 lbs

were released to water and land, respectively (Ref. 55, TRI, 1990). For 1988, TRI indicates that20,085 lbs were released to air, 98,692lbs were released to water, and 257 lbs were released to land (Ref.55, TRI, 1990).
I. Chemical Fate Information

2,4-Dinitrophenol is expected to rapidly degrade in the atmosphere through oxidative reactions with photochemically produced hydroxyl radicals and through the night-time reaction with nitrate radicals (Ref. 3, Atkinson 1987, Ref.4, Atkinson et al., 1984, Ref. 5, Atkinson et al., 1987). Limited data are available on the fate of 2,4-dinitrophenol in water. Based on the Henry's Law constant, volatilization is not expected tobe a significant process (Ref.36, Lyman et al., 1982). Screening studies suggest that 2,4-dinitrophenol degrades fast under aerobic conditions after acclimation (Ref. 7,BIODEG 1990) however, data are limited. Under anaerobic conditions in flooded soils, loss is rapid and appears to be via reduction to the corresponding amine (Ref.7, BIODEG, 1990; Ref. 29, Khoping and Wiegel, 1987). It is not clear, however, whether biodegradation or abiotic degradation is occurring or whether degradation proceeds beyond loss ofthe parent compound. The Committee recommends chemical fate testing because there are insufficient data to reasonably determine or predict the persistence of2,4-dinitrophenol and because there are potentially substantial environmental releases.
II. Health Effects Information

Pharmacokinetic studies for 2,4- dinitrophenol included an intraperitoneal study inrabbits and ducklings that indicated that uptake from the peritoneal cavity was very rapid (peak serum levels were obtained 

### inrabbits within5 minutes of treatment) (Ref.20, Gehring and Buerge, 1969). Pharmacokinetic studies alsoincluded in vitro(Ref. 42 Parker, 1952;Ref. 17, Eiseman et al., 1974) and in viva {Ref. 43. Perkins, 1919; Ref. 61, Williams,1959; Ref.48, Senczuk et al., 1971) metabolism studies that indicated that reduction and conjugation are the major biotransformation pathways.

A review ofthe therapeutic use of2,4- dinitrophenol to correct obesity in humans reported over 100cases of cataract formation at the lower range of the recommended therapeutic dose, 2mg per kg per day (Ref.20, Homer, 1942). The study did not identify a NOAEL for this effect. A 6-month study in male rats fed diets containing 0.01, 0.02, 0.05 or0.2 percent 2,4-dinitrophenol identified a threshold forweight loss in rats, but cataracts werenot reported even at doses sufficient to cause severe emaciation ordeath (Ref. 51, Spencer et al., 1948).

Data regarding reproductive and developmental effects were limited. Female rats treated by gavage twice daily with 20 mg/kg, from 8days before mating through lactation, delivered more stillborn per litter and more litters with higher neonatal mortality than controls (Ref. 63, Wulffet al., 1935). Pregnant mice treated by gavage (25.5 or 38.3 mg/ kg) orintraperitoneal injection (7.7 or 13.6 mg/kg) during a portion ofgestation

were hyperexcitable and hyperthermic; embryotoxicity [not specified) was also observed (Ref.21, Gibson, 1973).

2,4-Dinitrophenol induced mutations inE. coli(Ref. 15, Demerec et al.,1951) but not in Salmonella

### (Ref. 14, Deflora, 

### 1981) and produced chromatid breaks in bone marrow cells ofmice treated by intraperitoneal injection.Oncogenicity data were limited to dermal studies in which 2,4-dinitrophenol was not a complete carcinogen (Ref.51, Spencer et al., 1948) or a tumor promoter(Ref. 8, Boutwell and Bosch, 1959 Ref. 53, Stenback and Garcia, 1975).

NIOSH supported the EPA nomination and recommended dermal absorption testing.The Committee recommends health effects testing because there are insufficient data to reasonably determine or predict health effects and because these data are needed to reduce the uncertainty associated with risk assessments for2,4-dinitrophenol. III. Ecological Effects Information

The toxicity of2,4-dinitrophenol has been tested in five .speciesof algae (Ref. 27, Huang and Gloyna, 1967; Ref. 13. Dedonder and Van Sumere, 1971;Ref. 57, U.S. EPA, 1978; Ref. 10, Bringmann and Kuhn, 1978;Ref. 2, AQUIRE, 1990) 

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and in duckweed (Ref. 50, Simon and Blackman, 1953; Ref. 2, AQUIRE, 1990). Acute toxicity has been tested in invertebrates (Ref. 6,Bernstein, 1955; Ref. 30, Kojima, 1960; Ref. 31, Kopperman et al., 1974; Ref. 9, Bringmann and Kuhn, 1977; Ref. 57, U.S. EPA, 1978; Ref. 2, AQUIRE. 1990), fish (Ref. 44, Phipps et al., n.d.; Ref. 64, Zitko et al., 1976; Ref. 57, U.S. EPA, 1978; Ref. 2, AQUIRE, 1990) and bullfrogs (Ref. 33, Lewis and Frieden, 1959). An acute oral toxicity test in birds has been reported (Ref. 45, RTECS, 1990). The Committee recommends ecological effects testing because there are insufficient data to reasonably determine or predict the ecological effects of 2,4-dinitrophenol and because there are potentially substantial environmental releases. 3,4-Dimethylphenol PhysicalandChemicalInformation

CASNumber: 95-65-8 Synonyms and Trade Names: 3,4-Xylenol Empirical Formula: CsHioO Molecular Weight: 122.2 Physical State at 250 C: Solid Description ofChemical: White crystalline solid (Ref.34, Lide, 1990)

Melting Point: 67* C 

### (Ref. 34, Lide, 1990) Boiling Point: 225 (Ref.34, Lide. 1990) Vapor Pressure: 

### 0.075 mm 

### Hg @ 20*C 

### (Ref. 60, Weber 

### et al., 1981)

Specific Gravity: 0.9830 (Ref.34, Lide, 1990)

Log Octanol/Water Partition Coefficient: 2.23 (Ref.25, Hansch and Leo, 1981)

Water Solubility at 25 oC: 50,000 mg/L (Ref. 18,Fiege and Bayer, 1987)

Log K, 1.06 (Ref.36, Lyman et al., 1982) Henry's Constant: 7.56 

### X 107 atm m3 mole" (Ref. 36, Lyman et al., 1982)

pK,: 8.42 (Ref.39, Miller and Faust, 1973)
Rationale forRecommendations
A. ExposureInformationProduction/use/disposal/exposure/ release.In 1977,between .21 to 2.1 million pounds of3,4-dimethylphenol

were produced in the United States (Ref. 56,TSCAPP, 1990). Information on current production volumes is CBI, but production is substantial. 3,4- Dimethylphenol, as a mixture with other xylenols, isused in disinfectants, solvents, pharmaceuticals, insecticides and fungicides, plasticizers, rubber chemicals, additives to lubricants and gasoline, and dyestuffs (Ref.46, Sax and Lewis, 1987).

B. Evidence forexposure-Human exposure.The NOES survey estimated that 93 workers (56 females) were potentially exposed to trade name products containing 3,4-dimethylphenol (Ref.41, NIOSH, 1990). 3,4- Dimethylphenol has been qualitatively identified in the drinking water supplies of Cincinnati, OH (Ref. 35, Lucas, 1984). The mean concentration of3,4- dimethylphenol in the air ofPortland, OR during 7 rain events in 1984 was 2.2 ppt, while the concentration of3,4- dimethylphenol in the rain ranged from 54 to 190 ng/L (Ref. 32, Leuenberger et al., 1985). It was detected in groundwater samples from a wood preserving facility in Florida at a concentration of 2.4 mg/L, while the concentration of 3,4-dimethylphenol 330

m from the site was 0.85 mg/L (Ref. 22, Goerlitz et al., 1985). 3,4-Dimethylphenol also was detected in underground wells

near a coal gasification site (Ref. 54, Stuermer et al., 1982).

Environmental exposure.3,4- Dimethylphenol was detected in 10 samples obtained from 8 industries and POTWs at a maximum concentration of 3ppm (Ref.49, Shackelford et al., 1983). The concentration of3,4-dimethylphenol in the raw effluent from a paper mill

was 0.0457 mg/L (Ref.28, Keith, 1976). It

was detected in Los Angeles county effluent during 1980-81 at a concentration of20 gig/L (Ref.24, Gossett et al., 1983). 3,4-Dimethylphenol

was also found in refinery effluent in Australia at 0.02 mg/L (Ref. 11, Cardwell et al., 1986). 3,4-Dimethylphenol was qualitatively detected in samples taken from the Saint Lawrence River (Ref. 59, Visser et al., 1977). It was also identified in the leachate of a sanitary landfill in Barcelona, Spain (Ref. 1, Albaiges et al., 1986).
I.Chemical Fate Information

Atmospheric degradation by photochemically produced hydroxyl radicals should be a rapid removal process for 3,4-dimethylphenol in sunlight (Ref.3, Atkinson, 1987); degradation at night should be more rapid in urban areas through the reaction with nitrate radicals (Ref.12, Carter, 1981). Also, rain washout is expected to be an effective method of atmospheric removal for 3,4- dimethylphenol (Ref. 32, Leuenberger et al., 1985). Limited data are available on the fate of3,4-dimethylphenol in water. Volatilization from water is not expected to be a significant removal process based on the Henry's Law constant (Ref.36, Lyman et al, 1982). In humic waters, reaction with alkyl peroxy radicals should occur (Ref.38, Mill, 1982); however, no chemical specific data are available. Screening studies suggests that 3,4-dimethylphenol biodegrades fast under aerobic conditions without acclimation (Ref. 7, BIODEG, 1990); however, data are somewhat limited and no studies ofthe degradation of3,4-dimethylpheriol in environmental water samples are available. One grab sample study at high concentration (500 ppm) in soil suggests that 3,4-dimethylphenol biodegrades in soil; however, the data do not adequately predict the biodegradation of3,4-dimethylphenol at low concentrations. Under anaerobic conditions, one screening study indicates that 3,4-dimethylphenol isnot expected to biodegrade (Ref.7, BIODEG, 1990). The Committee recommends chemical fate testing because there are insufficient data to reasonably determine or predict the persistence of 3,4-dimethylphenol and because there

are potentially substantial environmental releases.
II. Health Effects Information

Data related to the pharmacokinetics of3,4-dimethylphenol were limited to a single study in male Wistar rats that reported recovery of93.5 percent ofthe radioactivity in the urine within 24 hours ofgiving a single oral 35 mg/kg dose (Ref.40, Miyamoto et al., 1969).

In two reports ofan 8-month rat gavage study, histopathological changes in the liver, spleen and kidneys and changes in body weight and blood pressure were observed in 53 male rats treated with 1.4 or 14 mgper kg per day (Ref.58, Veldre and Janes, 1979 and Ref. 37, Maazik, 1968). Increased relative liver and spleen weights, decreased body weight gain and marked atrophy and parenchymatous dystrophy ofliver cells were observed in 10male albino rats treated by gavage with 72.5 mg per kg per day for 10 weeks (Ref. 37, Maazik, 

### 1968).

Data on the developmental toxicity or reproductive effects of3,4- dimethylphenol were not located. Oncogenicity data were limited to a dermal study that identified 3,4- dimethylphenol as a complete carcinogen and a tumor promoter in a
mouse skin assay (Ref. 8,Boutwell and Bosch, 1959). In the promotion study groups of30 female Sutter mice were treated with an initial application of75 pg dimethylbenzanthracene followed by 25 .&L of20 percent 3,4-dimethylphenol in benzene twice weekly for 15 weeks. The mice were sacrificed at 23 weeks. In the complete carcinogen study 25 AL of 10 percent 3,4-dimethylphenol was applied twice weekly for 20 weeks and the mice were sacrificed at 28 weeks. Mutagenicity testing of34- dimethylphenol was limited to a single study inwhich the compound was negative with and without metabolic activation in the reverse mutation test in 4 strains ofSalmonella (Ref.19, Florin et al., 1980).

The Committee recommends health effects testing because there are 

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## / Wednesday, March 6, 1991 / Notices

insufficient data toreasonably determine or predict health effects and because these data are needed to reduce the uncertainty associated with risk assessments for 3.4-dimethylphenol.
III. Ecological Effects Information

Some acute aquatic toxicity data are available forgreen algae, sea urchins, sand shrimp and fathead minnows (Ref. 2, AQUIRE, 1990). No algal EC5odata

were available. The Committee recommends ecological effects testing because there are insufficient data to reasonably determine or predict the ecological effects of 3,4-dimethylphenol.

References

(1) Albaiges, 

### J., Casado, F., and Ventura, P. "Organic indicators ofgroundwater pollution by a sanitary landfill." WaterResources. 20(9): 1153-1159 (1986).

(2) AQUIRE. Aquatic Toxicity Information Retrieval Data Base. Duluth, MN: U.S. Environmental Protection Agency, Environmental Research Laboratory (1990).

(3)Atkinson,R. "A structure-activity relationship for the estimation ofrate constants forgas-phase reactions ofOH radicals withorganic compounds." International Journal ofChemicalKinetics. 19:799-828 (1987).

(4) Atkinson,R.A.. Carter, W.P.L., Plum, C.N., Winer, A.M.. and Pitts, J.N., Jr. "Kinetics ofthe gas-phase reactions ofNO 3radicals with a series ofaromatics at 296 * 2K:' International Journal ofChemicalKinetics. 16: 887-898 (1984).

(5) Atkinson, R., Aschmann. S.M., and Winer, A.M. "Kinetics ofthe reactions of N03 radicals witha series ofaromatic compounds." EnvironmentalScienceand Technology. 21:11231126 (1987).

(6) Bernstein, G.S. "Effect of 2,4dinitrophenol onsea urchin sperm." Proceedings oftheSociety forExperimental BiologyandMedicine09: 28 (1955).

(7)BIODEG. (Database). Syracuse, NY: Syracuse Research Corporation [1990).

(8) Boutwell, R.K., and Bosch, D.K. "The tumor-promoting action ofphenol and related compounds for mouse skin." Cancer Research.19: 413-474 (1959).

(9) Bringmann G. and Kuhn, R. "Limiting values for the damaging action ofwater pollutants orbacteria {Pseudomonas putida) and green algae (Scenedesmus quadricauda) in the cell multiplication inhibition test." Zeitschrift fuer WasserundAbwasser Forschung. 10 87-9811977). (10) Bringmann. G., and Kuhn, R. "Testing ofsubstances for their toxicicty threshold. Model organismsMicrocystis (Diplocytis) and Scenedesmus quadricauda." Mitteilungen

-Internationale Vereiningung fuer TheoretischeandAngewandte Limnologie.21:275 (1978).

(11) Cardwell, T.J.. et al. "Determination of alkyl phenols inrefinery effluents by liquid chromatography using electrochemical detection." International Journal of Environmental AnalyticalChemistry.24: 23- 36 (1986).

(12) Carter. W.P.L; Winer. A.M.: Pitts. I.N.]r. Major Atmospheric Sink for Phenol and the Cresols. Reaction with Nitrate Radical. EnvironmentalScience Technology 15:829-31. (1981).

(13) Dedonder, A.,and Van Sumere, C.F. "The Effect ofphenolics and related compounds on the growth and therespiration of Chlorellavulgaris Zeutschrift fuer Pflanzenphysiologie.65(1): 7080 (1971).

(14)DeFlora, S. "Study of 106 organic and inorganic compounds in the Salmonella! microsome test." Carcinogenesis (London). 2(4): 283-298 (1981).

(15) Demerec, M., Bertani, G., and Flint, J. "Asurvey of chemicals for mutagenic action

onE. coli. "AmericanNaturalist. 85: 119 (1951).

(16) Eckel, W.P., Trees, D.P., and Kovell, S.P. "Distribution and concentration of Proceedings, National Conference on Hazardous Wastes and Environmental Emergencies, Superfund, Hazardous Materials Control Research Institute, Silver Spring, MD. pp. 250-257 (1986).

(17) Eiseman J.L., et al "Kinetics ofin vitro nitro reduction of 2.4-dinitrophenol by rat liver homogenates." Toxicology and Applied Pharmacology. 27: 140 (1974). (18) Fiege, H. "Cresols and xylenols." In: Ullmann'sEncyclopediaof Industrial Chemistry.5th edition. A& 25-59 (1987).

(19) Florin,I., Rutberg, L., Curvall, M., and Enzell. C.R. "Screening oftobacco smoke constituents for mutagenicity using the Ames test." Toxicology.18:219-232 (1980).

(20)Gehring, P.J., andBuerge, J.F. "The distribution of24-dinitrophenol relative to its cataractogenic activity in ducklings and rabbits." Toxicology and Applied Pharmacology. 15: 574-592 (1969). (21) Gibson, J.E. "Teratology studies in mice with 2-sec-butyl-4,6-dinitrophenol (dinoseb)." FoodandCosmetics Toxicology. 11: 31 (1973).

(22) Goerlitz, D.F., Troutman. D.E., Godsy, EM., andFranks, B.. "Migration ofwoodpreserving chemicals in contaminated groundwater in a sand aquifer at Pensacola, Florida." Environmental Scienceand Technology.19(10): 955-961 (1985).

(23) Gordon, A.J., and Ford. RA. The Chemists Companion. New York, NY: John Wiley and Sons.p. 61 (1972).

(24) Gossett. R.W.,Brown, D.A., and Young, D.R."Predicting the bioaccumulation of organic compounds in marine organisms using octanol/water partition coefficients." MarinePollutionBulletin. 14(10): 387-392 (1983).

(25) Hansch, C.,and Leo, A.J. Medchem Project. Issue Nos. 19. 26.Claremont, CA. Pomona College (1981).

(26) Homer. W.D. "Dinitrophenol and its relation to formation ofcataract." Archivesof Ophthalmology.27:1097 (1942).

(27) Huang. J., and Gloyna. E. "Effects of toxic organics on photosynthetic reoxygenation." Environmental Health Engineering Research Lab. PB 216-749. (1967).

(28) Keith, L.H. "Identification oforganic compounds in unbleached treated kraft paper mill wastewaters." Environmental Science andTechnology. 10:555-564 (1976).

(29) Khoping, G.W. and Wigel, J. "Influence oftemperature on the anaerobic degradation ofsubstituted phenols in freshwater lake sediments."American SocietyforMicrobiology, Abstracts of87th AnnualMeeting,Atlanta, GA. (1987).

(30) Kojima, H.K. "The effect ofDNP and NaN 3 on fertilized eggs ofthe sea urchin with special reference to the induction ofthe abnormal cleavage." Embryologia.5: 71 (1960).

(31) Kopperman, H.L,et al. "Aqueous chlorination and ozonation studies. L Structuretoxiclcty correlations ofphenolic compounds to Daphnia magna." ChemicoBiologicalInteractions. 9: 245 (1974). (32) Leuenberger, C.,Ligocki, M.P., and Pankow, J.F. "Trace organic compounds in rain. 4. Identities, concentraions, and scavenging mechanisms forphenols inurban airand rain." Environmental Scienceand Technology.19: 10531058 (185).

(33) Lewis, E.J.C., and Frieden.E. "Biochemistry ofamphibian metamorphosis: Effect of triiodothyronine, thyroxin, and dinitrophenol on the respiration ofthe tadpole." Endocrinology. 85: 273(1959). (34) Lide, D.R. CRC Handbook ofChemistry and Physics. 71st edition.Boca Raton, FL: CRC Press. pp. 3-18, 3-27, 3-381, 3-382 (1990).

(35)Lucas; SV. "GC/MS analysis of organics in drinking water concentrates and advanced waste treatment concentrates." EPA600/1-84-020C. Columbus, OH: Columbus Health Effects Research Labs. 3:50-54 (1984).

(36) Lyman, W.J., Reehl, W.F.,and Rosenblatt, D.H. Handbook ofChemical Property Estimation Methods.New York. NY: McGraw-Hill. Chapters 4,7,15 11982).

(37) Maazik, LK. "Standards for dimethylphenol isomers in water bodies." Gigiena ISanitaria. (Hygiene andSanitation). 11: 2835 (1968).

(38) Mill, T. Hydrolysis and oxidation processes in theenvironment Environmental and Toxicological Chemistry 1: 135-41. (1982).

(39) Miller. R.W., and Faust, S.D. -'Sorption from aqueous solution by Organo-Clay. IIl. The effect ofpHon sorption of various phenols." EnvironmentalLetters.4:" 211-223 (1973).

(40) Miyamoto, J,Yamamoto, K.,and Matsumoto, T."Metabolism of3,4- dimethylphenyl-N-methylcarbamate in white rats." AgriculturalandBiologicalChemistry. 33(7): 1060-1073 11969).

(41) NIOSH (National Institute for Occupational Safety and Health). National Occupational Exposure Survey (NOES) (1990).

(42)Parker. V.H. "Enzymic reduction of 2,4-dinitrophenol by rat-tissue homogenates." Biochemical Journal. 51: 363 (1952).

(43) Perkins, R.G. "A study ofthe munitions intoxications in France." PubicHealth Reports.34: 2335 (1919).

(44) Phipps, G.L., et al. "The acute toxicity of phenol and substituted phenols to the fathead minnow." fmanuscript) (n.d.],

(45) RTECS. Online database. (1990). (46)Sax,N.,and Lewis, R.J.Haweleyls Condensed Chemical Dictionary. 11th edition. New York, NY: VanNostrand Reinhold Company. pp. 910,411, 421896-897, 1244 (1987).

(47) Schwarzenbach. R.P., et al. "Compound properties relevant for assessing 

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the environmental partitioning of nitrophenols." Environmental Science and Technology.22: 83-92 (1988).

(48) Senczuk, W., et al. "Excretion of 2,4dinitrophenol and 2--amino-4-- nitropheno!." Bromatologiai Chemia Toksykologiczna. 4:453460 (1971).

(49) Shackelford, W.M., Cline, D.M., Fass, L, and Kurth,G. "An evaluation of automated spectrum matching for survey identification ofwastewater components by gas chromatography-mass spectrometry." AnalyticaChemicaActa. 146:1527 [supplemental data] (1983).

(50) Simon. E.W.. and Blackman, G.E. "Studies in the principles ofphytotoxicity.IV. The efffects ofthe degree ofnitration on the toxicicty ofphenol and other substituted benzenes." Journal ofExperimental Botany. 4: 235 (1953).

(51) Spencer, H.C., Rowe, V.K, Adams, E.M., and Irish, D.D. "Toxicological studies
on laboratory animals ofcertain alkyl dinitrophenols used in agriculture." Journal of Industrial HygieneandToxicology.30:10-25 (1948).

(52) Staples, C., Wener, A.. and Hoogheem, T. "Assessment ofpriority pollutant concentrations in theUnited States using STORET database." Environmental Toxicology andChemistry. 4:131-142 (1985). (53) Stenback, F., and Garcia. H. "Studies
on the modifying effect ofdimethyl sulfoxide and other chemicals on experimental skin tumor induction."Annals oftheNew York Academy of Sciences.243: 209 (1975). (54) Stuermer, D.FL,Ng. D.J., and Morris, C.J. "Organic contaminants in groundwater
near an underground coalgassification site in northeastern Wyoming." Environmental Science andTechnology.16(9): 582-587 (1982).

(55) TRI (Toxics Release Inventory). Database retrieval 3/16/90. U.S. EPA. (1990).

(56) TSCAPP. Computer print-out of nonconfidential production data from TSCA inventory. Washington, DC: OTS, CID, U.S. EPA. Online 3/15/90 (1990).

(57) U.S. EPA. "In-depth studies onhealth and environmental impacts ofselected water pollutants." U.S. Environmental Protection Agency. Contract No. 68-01-4646. (1978).

(58) Veldre, I.A., and Janes. H.J. "Toxicological studies ofshale oils,some of their components and commercial products." EnvironmentalHealthPerspectives.30.141- 146 (1979).

(59) Visser, S.A., Lamontagne, G., Zoulalian,V.,and Tessier, A. "Bacteria active in the degradation ofphenols in polluted waters ofthe St. Lawrence River." Archives of

EnvironmentalContaminationand Toxicology.6(4): 455-469 (1977).

(60] Weber,R.C., Parker, P.A., and Bowser, M. Vapor Pressure Distribution ofSelected Organic Chemicals. EPA-600/2--81-021. Cincinnati, OH: U.S. EPA. (1981).

(61)Williams,R.T. The metabolism and detoxication ofdrugs, toxic substances and other organic compounds. 2nd edition. New York, NY: John Wiley and Sons. (1959).

(62) Windholz, M. Budavari. S.,Blumetti, R.F., and Otterbein, E.S., The Merck Index. 10th edition. Rahway, New Jersey: Merck Co., Inc.. pp.19, 478-479, 545. 1043 (1983).

(63) Wulff, LM.R., Emge, LA., and Bravo, F. "Some effects ofalpha-dinitrophenol on pregnancy inthe white rat." Proceedings of the SocietyforExperimentalBiologyand Medicine.32: 678 (1935).

(64) Zitko, V., et aL "Toxicity of alkyldinitrophenols to some aquatic organisms." BulletinofEnvironmental ContaminationandToxicology.16:508-515 (1976).

2.4.b N-Phenyl-1-napthylamine. N

### phenyl-1-naphthylamine was nominated to the Committee by OSHA as an ongoing effort to identify chemicals for which Permissable Exposure Limits may be proposed.

Summary ofrecommendedstudies. 

### Recommended studies are summarized in Table 1. 

### N-Phenyl--napthylamine PhysicalandChemicalInformation

CAS Number: 90-30-2 Synonyms and Trade Names: Vulkanox PAN

Empirical Formula: C16 H13 N Molecular Weight- 219.29 Physical State at25' C: Solid Melting Point: 60-62' C(Ref. 1,Aldrich, 1988)

Boiling Point: 335' C(Ref.16, Sax and Lewis, 1987)

Water Solubility @ 25' C: .10 mgfL (Ref. 4,Greenhouse, 1976)

LogOctanol/Water Partition Coefficient: 4.8 (Estimated, Ref.11,Lyman et al., 1982)

Log Koc: 3.7 (Estimated,Ref. 11, Lyman et al., 1982)
Rationale forRecommendation A. ExposureInformationProduction/use/disposal/exposure/ release. N-Phenyl-1-naphthylamine is 

### used as an antioxidant in rubber, silicone oils,paraffinic oils for lubrication, anti-rust oils,paint, and plastics, and in the manufacture ofdyes and other organic chemicals (Ref.9, Kirk-Othmer, 1981, Ref. 12, Meylan et al., 1976, Ref. 10, Kirk-Othmer, 1981, Ref. 8. 

### Kirk-Othmer, 1967,Ref. 16, Sax and 

### Lewis, 1987, Ref. 6, Jarvholm and Lavenius, 1981, Ref. 18, Sikka et al., 

### 1981). While actual production volumes

are CBI, N-phenyl-1-naphthylamine is produced in substantial quantities.

B. Evidence forexposure-Human 

### exposure.The NOES conducted during 1981-83 by NIOSH estimated that 96,478 workers (8,274 females) werepotentially exposed toN-phenyl-1-naphthylamine, almost exclusively through trade name products (Ref. 13, NIOSH, 1990).

Environmentalexposure.N-Phenyl-1- naphthylamine has been detected (but not quantified) in the wastewater of a chemical specialty plant as well as in the river water and sediment receiving the wastewater (Ref. 7, Jungclaus et al., 1978]. In a wastewater survey conducted by the Effluent Guidelines Division of EPA, over 4,000 wastewater samples 

### from industrial facilities and publicly owned treatment works were surveyed (Ref.17, Shackelford et al., 1983). This 

### survey found N-phenyl-l-naphthylamine in one sample from the non-ferrous metals industry at a concentration of 8.46 ppb.


### I.Chemical Fate Information

N-phenyl-1-naphthylamine has been tested for biodegradation in a number of screening studies as well as in soil and freshwater grab samples (Ref. 15, Rosenberg, 1983, Ref. 18, Sikka et al., 1981). In screening studies using sewage sludge as the inoculum and N-phenyl-1- naphthylamine at2 mg/L, the time to 50 percent disappearance was approximately 4.2 days. Autoclaved 

### sewage showed less than 20 percent removal after 18 days. In lake water dosed with 2mg/L N-phenyl-1- naphthylamine, no degradation was observed in the first 5days, but approximately 50percent disappearance

was observed after 10 days. No further 

### degradation was seen at day 18. In soil exposed to N-phenyl-1-naphthylamine at 1.54 mg/kg, 17 percent ofN-phenyl-1- naphthylamine was mineralized to CO2 

### after 11 days. Sterile samples ofwater and soil showed almost no degradation. When exposed to sunlight, distilled water solutions ofN-phenyl-1- naphthylamine had a half-life of5.7 

### days. The Committee recommends chemical fate testing because there are insufficient data to reasonably determine or predict the persistence of N-phenyl-1-naphthylamine.
II. Health Effects Information

Pharmacokinetics studies in rats indicate that N-phenyl-1-naphthylamine is rapidly absorbed and distributed 

### widely following gavage administration (Ref.18, Sikka et al., 1981). Theurine and the feces are the primary routes of excretion with 35 and 60 percent, respectively, ofthe dose eliminated by each route after 72 hours. In vitro metabolism with rat liver microsomes produced the mono- and dihydroxy derivatives as well as other metabolites (Ref. 18, Sikka et al., 1981).

Negative results have been reported in

a reverse mutation assay inbacteria, a 

### forward mutation assay in cultured mammalian cells, a dominant lethal assay inrodents, and unscheduled DNA 

### synthesis in cultured cells (Ref. 2, Brusick and Matheson, 1977). NTP also reported negative results in bacterial

reverse mutation assays and in a chromosomal aberration assay in cultured mammalian cells, but reported positive results in a sister chromatid 

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exchange assay in cultured cells (Ref. 14, NTP, 1990).

In an oncogenicity study, groups of23 to 25male mice were administered purified N-phenyl-l-naphthylamine by subcutaneous injection 3times per week for 9weeks (Ref. 19, Wang et al., 1984). The mice were observed after the administration ofN-phenyl-1- naphthylamine; after the lath month of observation a statistically significant higher incidence oftotal malignant tumors, lung carcinomas, and hemangiosarcomas was recorded. Technical grade N-phenyl-1- naphthylamine produced similar effects. Although the tumor incidence was increased, the response was not clearly dose related. In a second experiment, using a different strain ofmice, unilateral nephrectomy appeared to enhance the development ofrenal hemangiosarcomas. In a study with insufficient detail to allow for the evaluation of the data, dogs that were orally administered N-phenyl-1- naphthylamine for 3.5 years had no observed increase in the incidence of bladder tumors (Ref.3, Du Pont, 1945].

In Sweden, a cohort of20 men and 78

women who were exposed toN-phenyl1-naphthylamine in an anti-rust oil used for packingbearings were studied (Ref. 6, Jarvholm and Lavenius, 1981). The oil contained 50 percent white spirits, 16.5 percent each ofmineral oil, lanolin, and zinc naphthenate, and 0.5 percentNphenyl-l-naphthylamine, while the paper used as packing material for the bearings contained sodium nitrite. The authors note the potential for forming the nitrosamine ofN-phenyl-1- naphthylamine. The workers were exposed any time between 1954 to 1957 and followed until 1976. When compared to national gender- and agespecific cancer rates, there was an increased rate ofmorbidity and mortality from cancer in women. There

was no site specific increase in incidence ofcancer, with tumors ofthe colon, breast, uterus, ovary, bladder, brain, and thyroid reported, along with a reticulosarcoma. This study provides inconclusive evidence that N-phenyl-1- naphthylamine is carcinogenic in humans, because ofthe small group size, the lack of increase in site-specific
cancers, and confounders from exposure to multiple chemicals.

The Committee recommends health effects testing because there are insufficient data toreasonably determine or predict the health effects of N-phenyl-l-naphthylamine and because there are potentially substantial human exposures. III. Ecological Effects Information
A 48-hour ECso of 2.1 mg/L was reported for larval Xenopus laevis (South African clawed toad) (Ref. 5, Greenhouse, 1977). Concentrations of

- 5 mg/L caused 100 percent mortality in larval Ranapipiens(Leopard frog) after 48-hour's exposure (Ref. 4, Greenhouse, 1976). N-Phenyl-l-naphthylamine caused teratogenic effects in both Xenopus 

### JoevisandRanapipiens(Ref. 5, Greenhouse, 1977, Ref.4, Greenhouse, 1976). A 48-hour and 21-day staticrenewal test in Daphniayielded LCeo values of0.68 mg/L and 0.06 mg/L, respectively (Ref.18, Sikka et al., 1981). The no observed effect concentration

was 0.13-0.36 and 0.02 mg/L for48-hour and 21-day exposure, respectively, but reproductive effects were not examined. The 8-day LCo values forbluegill and rainbow trout exposed to N-phenyl-1- naphthylamine under flow-through conditions were 0.48 and 0.30 mg/, respectively. No observable effect concentrations under the same conditions were 0.24 and 0.11 mg/L for bluegill and rainbow trout, respectively. The Committee recommends ecological effects testing because there are insufficient data toreasonably determine or predict the ecological effects ofN-phenyl-1-naphthylamine.
References

(1)Aldrich. Catalog Handbook ofFine Chemicals. p. 1206 (1988).

(2)Brusik, D., and Matheson, D. "Mutagenic evaluation of1,1- dimethylhydrazine, methylhydrazine andNphenyl-alpha-naphthylamine." In: Proceedings ofthe 7th Annual Conference on Environmental Toxicology. 13, 14 and 15 October 1976.Aerospace Medical Research Laboratory, Wright-Patterson Air Force Base, OH. NTIS No. AD/A--041 973.pp. 108-129 (1977).

(3)Du Pont. "Aniline tumors ofthe bladder. Studies ofurinary bladder tumors. Progress Report

-February, 1945." TSCA Submission Section 8(d) by E.I. Du Pont DeNemours and Co. U.S. EPA/OPTS Public Files. Fiche No. OTS0215025.

(4)Greenhouse, G. "The evaluation oftoxic effects ofchemicals in fresh water by using frog embryos and larvae." Environmental Pollution11:303-315 (1976).

(5)Greenhouse, G.A. "Toxicity ofNphenyl-a-naphthylamine and hydrazine to Xenopus loevisembryos and larvae." Bulletinof EnvironmentalContamination and Toxicology18:503-511 (1977).

(6)Jarvholm, B., and Lavenius, B."A cohort study on cancer among workers exposed to
an antirust oil." Scandj. Work Environ. Health.7:179-184 (1981).

(7)Jungclaus, G.A., Lopez-Avila, V., and Hites, R.A. "Organic compounds in an industrial wastewater A case study oftheir environmental impact." Environmental Scienceand Technology.12: 88-98 (1978). (8) Kirk-Othmer. EncyclopediaofChemical Technology.Volume 12. New York, NY: John Wiley &Sons. pp. 574-575 (1967).

(9) Kirk-Othmer. EncyclopediaofChemical Technology.Volume 15. New York, NY: John Wiley &Sons. pp. 726-727 (1981).

(10) Kirk-Othmer. Encyclopediaof ChemicalTechnology.Volume 20. New York, NY: John Wiley &Sons. pp. 938-939 (1981).

(11) Lyman, W.J., Reehl, W.F., and Rosenblatt, D.H. Handbook ofChemical Property Estimation Methods. New York, NY: McGraw-Hill. Chapters 1 and 4 (1982).

(12) Meylan, W.M., Howard,P.H., and Sack, M. "Chemical market input/output analysis of selected chemical substances to

assess sources ofenvironmental contamination: Task I. Naphthylamines." Washington, DC: Office ofToxic Substances, U.S. EPA. (1976).

(13) NIOSH. National Occupational Exposure Survey (NOES). National Institute for Occupational Safety and Health. p. 302 (1990).

(14) NTP (National Toxicology Program). Results report 1-3-90. p. 108 (1990).

(15) Rosenberg, A. "Microbial metabolism ofN-phenyl-l-naphthylamine in soil, soil suspensions, and aquatic ecosystems." Chemosphere.12:1517-1523 (1983).

(16) Sax, N.I., and Lewis, R.J. Hawley's Condensed Chemical Dictionary. 11th edition. New York, NY: Van Nostrand Reinhold Company. p. 905 (1987).

(17) Shackelford, W.M., Cline, D.M., Faas, L., and Kurth, G. "An evaluation of automated spectrum matching for survey identification ofwastewater components by gas chromatography-mass spectrometry". Analytica ChimicaActa .146:15-27 (1983).

(18) Sikka, H.C., Pack, E.J., Sugatt, R.H., Banerjee, S., Rosenberg, A., and Simson, B.W. "Environmental fate and effects ofN-phenyl1-naphthylamine and its disposition and metabolism in the rat." Springfield, VA: National Technical Information Service AD Al 06780 (1981).

(19) Wang, H.. Wang, D., and Dzeng, R. "Carcinogenicity ofN-phenyl-1- naphthylamine and N-phenyl-2- naphthylamine in mice." Cancer Research. 44:3098-3100 (1984).

2.4.c. Sulfones-summaryof recommendedStudies.Testing recommendations for the sulfones listed in the paragraph following Table 1 are summarized in Table 1.

Sulfones Physical and ChemicalInformation Except for the melting point ofbis(4- chlorophenyl)sulfone (146 C; Ref. 1, Aldrich, 1988), the log octanol/water partition coefficient (0.97; Ref. 5, Hansch and Leo, 1981) and pKa (2.41; Ref. 10, Perrin, 1965) of4,4'-diaminodiphenyl sulfone, the log octanol/water partition coefficient (-0.77; Ref. 5, Hansch and Leo, 1981), melting point (27 C; Ref. 1, Aldrich, 1988), boiling point (2850 C; Ref. 1, Aldrich, 1988), vapor pressure (7.70 X 10" mm Hg; Ref. 3, Daubert and Danner, 

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1989) and water solubility (3.79 X 105 mg/L; Ref. 2, Brown et al., 1975) of sulfolane, melting point (65-66 C; Ref. 1, Aldrich, 1988) ofsulfolene, and melting point ofbisphenol S(246" C; Ref.1, Aldrich, 1988), the Committee has no information on measured physical/ chemical properties ofthe sulfones listed in the paragraph following Table 1.
Rationale forRecommendation
A. ExposureInformationProduction/use/disposal/exposure/ release.The Committee believes that the sulfones listed in the paragraph following Table 1 are commercially available, and that many are produced in substantial quantities; actual volumes

are CBI. In 1977, many of the chemicals

were produced in quantities of0.1 to 20 million lbs per year (Ref. 11, TSCAPP, 1990).

Sulfolane is used primarily as a solvent for the extraction ofbenzene, toluene, and xylene from aliphatic hydrocarbon mixtures. It is also used for the removal ofacidic gases from natural gas and other gas streams, and ithas extensive application as a specialty solvent (Ref.8, MacGregor and Orle, 1983). Sulfolene is used as a specialty solvent inpetroleum refining and in the manufacture ofsulfolane (Ref.8, MacGregor and Orle, 1983). The unique thermal stability and properties ofthe sulfones are utilized in the manufacture ofspecialty products. For example, bis(4-chlorophenyl)sulfone is used in the manufacture ofengineering thermoplastics (Ref.8, MacGregor and Orle, 1983).

B.Evidence forexposure-Human exposure.Sulfolane, diphenylsulfone, dimethylsulfone, and bis(4- chlorophenyl)sulfone have been detected (no quantitative data available) in U.S. drinking water supplies (Ref. 7, Lucas, 1984; Ref.6, Kool et al., 1982). The NOES conducted during 1981-83 by NIOSH estimates that 6,461 workers

were potentially exposed to sulfolane and 1,510 were potentially exposed to sulfolene (Ref. 9,NIOSH, 1989).

I. Chemical Fate Information

Except for data on the slow biodegradation ofbis(4- chlorophenyl)sulfone in soil (Ref. 4, Guenzi and Beard, 1981), the Committee has no experimental chemical fate information on the sulfones listed in the paragraph following Table 1. Chemical fate testing isrecommended because data are insufficient to reasonably determine or predict the physical/ chemical properties ofsulfones. II.Health Effects Information
No health effects testing is recommended at this time. NTP's Board of Scientific Counselor's decision to defer a testing recommendation for bis(4-chlorophenyl)sulfone (referred to

aspp'-dichlorodiphenylsulfone by NTP) is consistent with the Committee's efforts to facilitate coordination of testing required or sponsored by U.S. Government organizations. The decision is also consistent with the Committee's procedures ofreviewing production and exposure data (submitted under TSCA section 8(a)) as well as unpublished health and safety studies (submitted under TSCA section 8(d)) that are recommended fortesting before designating subsequent health effects, chemical fate orecological effects testing.These TSCA section 8 data and studies are automatically required for any ITC recommendation.
Il. Ecological Effects Information

No ecological effects testing is recommended at this time.
References

(1) Aldrich. Cataloghandbookof fine chemicals.Milwaukee, WI: Aldrich Chemical Company. pp.96, 368, 1214 and 1410 (1988).

(2)Brown, S.L., Chan, F.Y.,Jones, J.L, Liu, D.H., McCaleb, K.E., Mill, T., Sapios, K.N. and Schendel, D.E. "Research program onhazard priority ranking ofmanufactured chemicals." Stanford Research Institute, Menlo Park, CA. NTIS PB-263-163 1975).

(3)Daubert, T.E. and Danner, R.P. "Physical and thermodynamic properties of pure chemicals: data compilation." Design Institute for Physical Property Data, American Institute ofChemical Engineers. New York, NY. Hemisphere Publishing Corp. Vol 4 (1989).

(4) Guenzi, W.D. and Beard,W.F. "Degradation ofp-chlorophenyl methyl sulfide, -sulfoxide, and -sulfone in soil." Soil Science.131(3):135-139 (1981).

(5)Hansch, C.and Leo, A.J. "Medchem project.: Issue No. 19.Pomona College, Claremont, CA. (1981).

(6) Kool, H.J., Van Kreijl,C.F. and Zoetman, B.C.J. "Toxicology assessment oforganic compounds in drinking water." Critical Reviews inEnvironmentalControl. 12:307- 353 (1982).

(7)Lucas, S.V. "GC/MS analysis of organics in drinking water concentrates and advanced waste treatment concentrates." Health Effects Research Lab, Columbus. OH. EPA-600/1-84-020A&C. 1:133-162, 

### 3:50-54 (1984).

(8)MacGregor, W.S. and Orle,J.V. "Sulfoxides." In:Kirk-Othmer Encyclopedia ofChemical Technology, 3rd. ed. A Stannden, Ed.John Wiley and Sons, New York, NY. 22:73-74 (1983).

(9)NIOSH. Department of National Industrial and Occupational Safety and Health, National Occupational Exposure Survey (NOES). p.302 (1989). (10) Pernin, D.D. "Dissociation constants of organic bases in aqueous solution." IUPAC Chemical Data Series, Buttersworth, London. England. (1965).

(11) TSCAPP. Computer Print-out ofnonconfidential production data from the TSCA Inventory, OTS,CID, U.S.Environmental Protection Agency, Washington, DC. 

### (1990).

2.4.d. Substantially produced chemicals inneedofsubchronictestsIntroduction.On May 17, 1989, a list of 166 substantially produced, commercial chemicals were discussed by the Committee because they were coded for exposure and adverse effects potentials in the ITC's computerized, substructurebased chemical selection system. This computerized system allows the Committee to cost-effectively screen chemicals by identifying chemical groups with exposure potentials or with adverse effects potentials and chemicals that have common testing information deficiencies, e.g. subchronic toxicity, fish chronic toxicity, biodegradation, physical/chemical properties, etc. For chemicals produced in substantial quantities and for which there may be potential occupational exposure or environmental release or for which there may be potential adverse effects

concerns and for which there appear to be.basic testing information deficiencies, there should be a minimum amount ofdata to identify potentially problematic chemicals, e.g., a minimum amount ofchemical fate, bioconcentration, bioaccumulation or ecological effects data should be available for potentially problematic chemicals (Ref.4, Walker, 1990). The concept of obtaining minimum data to identify potentially problematic chemicals is consistent with the OECD's approach to voluntarily obtaining SIDS for high production volume chemicals.

In addition to using their system to identify chemical groups ofconcern, the Committee uses their computerized system and associated processes to implement Member Agency testing nominations. EPA and other Member Agencies have taken advantage of the system and associated processes to facilitate nominations, e.g., EPA nominated isocyanates that were recommended for testing in the Committee's 26th Report and aldehydes that were recommended for testing in this Report. Using the computerized system and associated processes to facilitate nominations and transform them into subsequent Committee recommendations allows the nominatui to easily access Member Agency information through Committeeactivated interagency networking and provides the nominator with very rapid v

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access to TSCA section 8 information without notice and comment rulemaking. Member Agency information networking is used to promote cost-effective use ofU.S. Government chemical testing resources. The information submitted under TSCA 8(a) may provide access to production, exposure and environmental release confidential business information. Chemical fate, health effects, monitoring, epidemiology and ecological effects studies that couldbe submitted under TSCA 8(d) are tabulated for the nominator to facilitate identification and review ofsubmissions that appear to be identical to testing recommendations or that appear to indicate a potential

concern related to toxicity, exposure or persistence.

The May 17, 1989 ITC meeting during which the Committee discussed the 166 substantially produced chemicals was a planning meeting that was attended by industry and the Chemical Manufactures Association (CMA). After the meeting, CMA requested and received permission to make their members aware ofthe list of 166 substantially produced chemicals. CMA published the list of 166 substantially produced chemicals in their first issue ofCHEMSTAR news with a suggestion that their members submit any unpublished data to the Committee (Ref.1, CMA, 1989). In response to this suggestion, the Committee received a CBI submission for one chemical. The chemical for which the submission was received was
one for which CMA had established a panel ofrepresentatives from member companies.

Analysis of the 166 substantially produced chemicals identified by the Committee's computerized system revealed that many chemicals did not have minimum health effects data; 51 chemicals had no subchronic toxicity data. A few ofthese 51 chemicals had

no acute toxicity data; less than onethird ofthese 51 chemicals had mutagenicity data; most ofthese 51 chemicals had no reproductive effects, developmental toxicity, chronic toxicity, oncogenicity or neurotoxicity data. At least 22 ofthese 51 chemicals had NOES information indicating potential exposure to L_ 1,000 workers; 21 ofthese 51 chemicals had vapor pressures - 0.1 mmHg at ambient temperature indicating potential for accidental release and 9 ofthese 51 chemicals had octanol-water partition coefficients

- 1.000 indicating bioconcentration/ bioaccumulation potential. At the Committee's request, the EPA's Exposure Assessment Branch estimated the persistence ofthese 51 chemicals as 

### well as their potential consumer exposure. Also at the Committee's request, the EPA's Structure Activity Team reviewed available information on these 51 chemicals and expressed at least moderate concerns for the potential ofthese chemicals to cause adverse effects. Moderate concerns result when there is suggestive evidence in animal studies ofmutagenicity, reproductive effects, developmental toxicity, chronic toxicity, oncogenicity

or neurotoxicity or there is close homology (structural, functional or mechanistic] to chemicals with known toxicity. At the Committee's request, the EPA's Environmental Effects Branch also reviewed available information on these 51 chemicals and identified a number oftesting information deficiencies related to aquatic toxicity. These individual evaluations and more comprehensive analyses ofthe Toxic Substances Control ActTest Submissions database, ITCMember Agency computer files and recently developed OECD SIDS dossiers revealed that subchronic toxicity data
were available for 8 chemicals. After the individual evaluations and more comprehensive analyses, subchronic toxicity data could still notbe located for43 chemicals. An additional 8 chemicals forwhich no subchronic toxicity data were available are not being recommended at this time for subchronic toxicity testing, because these chemicals were recommended for other testing and the Committee wants
an opportunity to review theTSCA section 8(d) health and safety study submissions and determine ifthey include subchronic toxicity studies, before recommending subchronic toxicity testing.The Committee is recommending 35 substantially produced chemicals only for subchronic toxicity testing at this time,because it wants an opportunity to evaluate the production and exposure information and the health and safety studies that will be submitted under TSCA sections 8(a) and 8(d), respectively. The Committee believes that after evaluation of the TSCA 8(a) and 8(d) information, they will be able to make further recommendations as to which ofthese 35 chemicals EPA should add to a subchronic toxicity testing listing rule and which ofthese chemical should be referred to others (e.g., NTP, OECD, etc.) with an option for testing.Information available to the Committee indicates that each ofthe 35 chemicals is substantially produced in volumes ranging from 1million to 10billion pounds per annum, but actual production volumes are CBI. Summaryofrecommendedstudies. The substantially produced chemicals briefly described below and listed in the paragraph following Table 1are recommended for subchronic toxicity testing.

p,pOxybis(benzenesulfonylhydrazide). A search forphysical/chemical property data revealed a measured melting (decomposition) point of 160-161 degrees centigrade. It is used as a blowing agent for rubber and expanded plastics. There are considerable potential occupational exposures (NOES

= 1494 workers) as well as potential inhalation/dermal consumer exposures. There are moderate concerns for potential adverse effects and it was mutagenic in Salmonellaand caused unscheduled DNA synthesis in cultured cells.

Naphthalenedicarboxylic anhydride. A search forphysical/chemical property data revealed a measured melting point of267-269 degrees centigrade and a measured boiling point of422 degrees centigrade. It is used as an intermediate fordyes, pigments, fluorescent whiteners and pesticides. Itwas in a class ofanhydrides that NCI reviewed.

2-Ethylanthraquinone. A search for physical/chemical property data revealed a measured melting point of 108-111 degrees centigrade. It is used in chemical synthesis. There are potential occupational exposures (NOES = 483 workers) and moderate concerns for adverse effects. The LDsovalue in mice
was 200 mg/kg.

7-Amino-4-hydroxy-2- nophthalenesulfonic acid. A search for physical/chemical property data revealed none. It is used in onecomponent dry diazo copying process. There are potential occupational exposures (NOES = 737 workers) and potential dermal consumer exposures during changing ofink in copying machines. There are moderate concerns for potential adverse effects.

1-Naphthol.A search forphysical/ chemical property data revealed a measured melting point of96 degrees centigrade, a measured boiling point of 288 degrees centigrade, and a measured water solubility of866 mg/L It is used
as an intermediate for pesticides, drugs and dyes and in synthetic perfumes. There are substantial potential occupational exposures (NOES = 57,116 workers) as well as potential consumer exposures. There are moderate concerns forpotential adverse effects; it was mutagenic in Salmonellaand bacterial DNA repair assays. The LD 5

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were 2, 9, 134. 275, and 2,400 mg/kg, respectively.

3-Hydroxy-2-naphthoicacid. A search for physical/chemical property data revealed a measured melting point of 222-223 degrees centigrade. It is used in dyes and pigments. There are considerable potential occupational exposures (NOES = 1641 workers) and potential dermal consumer exposures. There are moderate concerns for potential adverse effects; the LDso value in mice was 800 mg/kg.

Triethyleneglycolbis(2- ethylhexonoate). A search for physical/ chemical property data revealed a measured boiling point of219 degrees centigrade at 5 torr. It is used as a plasticizer. There are moderate concerns forpotential adverse effects; LDso values in guinea pigs and rats were 21 and 31 mg/kg, respectively.

2-(4-Morpholinyldithio)- benzothiazole.A search forphysical/ chemical property data revealed none. It is used as an accelerator in rubber processing. There are potential occupational exposures (NOES = 174 workers) and moderate concerns for adverse effects.

N-butylacrylate.A search for physical/chemical property data revealed a measured melting point of 50 degrees centigrade, a measured boiling point of 160 degrees centigrade, and a measured vapor pressure of 2 mmHg at 20 degrees centigrade. It is used as a
monomer for resins, and in solvent coatings, adhesives, oil additives, emulsions for textiles, leathers and paper finishing. There are considerable potential occupational exposures (NOES

= 5,136 workers) and potential dermal

consumer exposures. There are moderate concerns for potential adverse effects; lowest threshold doses of2304 and 690 mg/kg were reported for days 5 and 15, respectively, during a rat developmental toxicity study.

m-Benzenedisulfonicacid.A search for physical/chemical property data revealed a measured melting point of 137 degrees centigrade. It is used as an intermediate in resorcinol production and as a nitration catalyst in mononitrotoluene synthesis. There are potential occupational exposures (NOES

= 56 workers) and moderate concerns for adverse effects.

3,4-Dichloronitrobenzene. A search for physical/chemical property data revealed a measured melting point of 40-42 degrees centigrade, a measured boiling point of 257-258 degrees centigrade, and a measured water solubility of0.63 mg/L. It is used as a pesticide intermediate. There are moderate concerns for potential adverse effects; it was a positive mutagen in Salmonella andDrosophila. The LD5o value in mice was 1,384 mg/kg.

Isophthaloylchloride.A search for physical/chemical property data revealed a measured melting point of 43-44 degrees centigrade and a measured boiling point of276 degrees centigrade. It is used as an intermediate for dyes, synthetic fibers, resins, films, protective coatings and laboratory reagents. There are potential occupational exposures (NOES = 46 workers) and moderate concerns for adverse effects. The LD5ovalue inmice

was 2,200 mg/kg. Terephthaloylchloride.A search for physical/chemical property data revealed a measured melting point of 79-81 degrees centigrade and a measured boiling point of 259 degrees centigrade. It is used as an intermediate for plasticizers, resins and polymers. There are potential occupational exposure (NOES = 212 workers) and moderate concerns for adverse effects. The LI6 value in mice was 2,140 mg/kg.

4-Ethoxynitrobenzene.A search for physical/chemical property data revealed a measured melting point of 60 degrees centigrade and a measured boiling point of283 degrees centigrade. It is used to manufacture dyes and intermediates. There are potential occupational exposures (NOES = 207 workers) and moderate concerns for adverse effects. It produced positive results in a Salmonellaassay, a Drosophiladominant lethal assay, a bacterial DNA test and a rat cytogenetic study. The LDso value in rats was 2,100 mg/kg.

Acetoacetanilide. A search for physical/chemical property data revealed a measured melting point of 85-86 degrees centigrade. It is used as a dyestuff intermediate, in organic synthesis and in rubber compounding. There are considerable potential occupational exposure (NOES = 1108 workers) and moderate concerns for adverse effects. The LD5ovalue in mice

was 3,400 mg/kg.

Butyricanhydride.A search for physical/chemical property data revealed a measured melting point of -75 degrees centigrade and a measured boiling point of200 degrees centigrade. It is used to manufacture butyrates, drugs and tanning agents. There are considerable potential occupational exposures (NOES = 4,817 workers] and moderate concerns for adverse effects. The LD5ovalue in mice was 2,000 mg/kg. It was In a class of anhydrides that NCI reviewed.

Isobutylacrylate.A search for physical/chemical property data revealed a measured boiling point of61- 63 degrees centigrade, a measured water solubility of 1800 mg/L and a measured vapor pressure of 10.7 mmHg at 20 degrees centigrade. It is used in synthesis ofacrylic ester polymers. There are moderate concerns for adverse effects. The LCso value in rats

was 2,000 ppm.

Diethyleneglycoldimethylether. A search for physical/chemical property data revealed a measured melting point of-68 degrees centigrade and a measured boiling point of 162 degrees centigrade. It is used as a solvent and in reaction medium for grignard and similar syntheses. There are potential occupational exposures (NOES = 207 workers) and moderate concerns for adverse effects. It was positive in a sperm morphology test and a dominant lethal test and caused adverse reproductive and developmental effects during short-term studies. The LDI)o value in mice was 2,978 mg/kg.

Carbinol acetate.A search for physical/chemical property data revealed a measured melting point of-25 degrees centigrade, a measured boiling point of217 degrees centigrade and a measured vapor pressure of0.1 mmHg at 20 degrees centigrade. It is used as a solvent for cellulose esters, gums and resins and to manufacture coatings, lacquers and printing inks. There are considerable potential occupational exposures (NOES = 7,649 workers) and moderate concerns for adverse effects and potential consumer exposures.

Bromamineacid.A search for physical/chemical property data revealed none. It Is used as a dye intermediate. There are potential occupational exposures (NOES = 737 workers) and moderate concerns for adverse effects.

4-Methyl-2-nitrophenol.A search for physical/chemical property data revealed a measured melting point of 108 degrees centigrade and a measured boiling point of234 degrees centigrade. It is used to manufacture dyes. There

are moderate concerns for adverse effects. The LD5ovalue in rats was 3,360 mg/kg.

4-(Acetylomino) benzenesulfonyl chloride.A search for physical/chemical property data revealed a measured melting point of149 degrees centigrade. It is used to manufacture sulfa drugs. There are considerable potential occupational exposures (NOES = 1.481 workers) and moderate concerns for adverse effects.

2,4-Pentanedione. A search for physical/chemical property data revealed a measured melting point of-23 degrees centigrade, a measured boiling point of 141 degrees centigrade, a measured water solubility of 125,000 v • "

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mg/L and a measured vapor pressure of 1.3 mmHg at 25 degrees centigrade. It is used as a solvent for cellulose acetate, a chelating agent formetals, as a lubricant additive and in paint dryers. There are considerable potential occupational exposures (NOES = 4,841 workers) and high concerns foradverse effects. It was mutagenic in chinese hamster ovary cells. The LD 8

### ovalue in rats was 1,000 ppm. EPAproposed a Significant New Use Rule based on reported neurotoxicity and production ofa nervous system disorder thatis characterized by an irreversible cerebellar syndrome in experimental animals, genotoxic effects and reported contact dermatitis and urticaria in humans (Ref. 2,EPA, 1989). In response to this proposal, Union Carbide submitted public comments and publications and reported that 2,4- pentanedione produced a "slight dominant lethal effect at the spermatid stage of spermatogenesis" and "no embryotoxicity or teratogenicity" to Fischer 344 rats (Ref.3,Union Carbide, 1989). Propanoic anhydride.A search for physical/chemical property data revealed a measured melting point of-45 degrees centigrade and a measured boiling pointof167-169 degrees centigrade. It isused as an esterifying agent for fats, oils, cellulose and a dehydrating medium for nitrations and sulfonations, alkyd resins, dyestuffs, and pharmaceuticals. There are potential occupational exposures (NOES

= 

### 489 workers) and moderate concerns for adverse effects. The LDso value in ratswas 2,360 mg/kg. It was in a class ofanhydrides thatNCI reviewed.

Bis(2-ethylhexyl)-2-butenedioate. A search forphysical/chemical property data revealed a measured boiling point of209 degrees centigrade. It is used in emulsions and copolymerized with vinyl acetate. There are considerable potential occupational exposures (NOES

= 3,352 workers) and moderate


### concerns for adverse effects.

Perfluorotributylamine. A search for physical/chemical property data revealed a measured boiling point of177 degrees centigrade. It is used in inert fluids and as a solvent. There are slight potential occupational exposures (NOES

= 7 workers) and moderate concerns for adverse effects. The LDbo value in mice

was 1,200 mg/kg.

Perfluoro-N-hexane. A search for physical/chemical property data revealed a measured melting point of-4 degrees centigrade and a measured boiling point of57 degrees centigrade. It is used in liquid fluorocarbons.

Trichloromethanesulfenyl chloride.A search for physical/chemical property data revealed a measured boiling point of 148-149 degrees centigrade and a measured vapor pressure of0.6 mmHg at 20 degrees centigrade. It is used in the synthesis oflubricant additives. There

are considerable potential occupational exposures (NOES = 7,790 workers) and moderate concerns for adverse effects. It

was a positive mutagen In a bacterial DNA assay. The LD 5ovalue in rats was 8 mg/kg.

1,2-Dichlorobutane. A search for physical/chemical property data revealed a measured boiling point of124 degrees centigrade and a measured vapor pressure of2.7 mmHg at 25 degrees centigrade. It is used as a butadiene intermediate. There are moderate concerns for adverse effects.

1,3-Dicyanobenzene.A search for physical/ chemical property data revealed a measured melting point of 160-162 degrees centigrade. It is used as
an intermediate for amines, synthetic fibers, agricultural chemicals, rust inhibitors and pharmaceuticals. There

are potential occupational exposures (NOES = 208 workers) and moderate

concerns for adverse effects. The LDso value in mice was 178 mg/kg.

3,4-Dichlarobutene. A search for physical/chemical property data revealed a measured melting point of-61 degrees centigrade, a measured boiling point of 115-117 degrees centigrade and

a measured vapor pressure of3.5 mmHg at 25 degrees centigrade. It is used as chloroprene and adiponitrile intermediates. There are moderate

concerns for adverse effects. The LDbo value inmice was 724 mg/kg. It was 

### positive in Salmonellaand in vivo cytogenetics assays.

2-(2-Aminoethoxy)-ethanol.A search for physical/chemical property data revealed a measured melting point of-13 degrees centigrade and a measured boiling point of221 degrees centigrade. It is used to remove acid components from gases. There are considerable potential occupational exposures (NOES

= 5,579 workers) and moderate

concerns foradverse effects. The LD 5

### o value in rats was 5,660 mg/kg.

Quinacridone. A search forphysical/ chemical property data revealed none. It is used as a dye and pigment. There are substantial potential occupational exposures (NOES = 23,292 workers) 

### and moderate concerns for adverse effects.

Ammonium carbamate. A search for physical/chemical property data revealed a measured melting point of 133-134 degrees centigrade. It is used in

urea manufacture.

Hexa(methoxymethyl)melamine. A search for physical/chemical property data revealed none. It is used during leather manufacturing, rubber bonding and to produce polyester powder coatings. There are substantial potential occupational exposures (NOES = 18,033 workers). TheLDo value In mice was 550 mg/kg. References

(1) CMA. Chemical Manufacturers Association. "ITCZeroes In." CHEMSTAR 

### NEWS. 1[1):4 (1989).

(2) EPA. EnvironmentalProtection Agency. 

### Proposed Rule. "2.4-Pentanedione; Proposed Significant New UseofaChemical Substance." 54FR 39548-39551, September 27, 1989.

(3) Union Carbide. "Comments ofUnion 

### Carbide Chemicals and Plastics Company, Inc. onEPA'sProposed Significant New Use Rule on 2,4-Pentanedione." Environmental Protection Agency,TSCA Public Reading Room, Washington.DC (October27, 1989).

(4) Walker, J.D. "Chemical fate, bioconcentration, and environmental effects testing: Proposed testing and decision criteria." ToxicityAssessment:An )nternationallournal. 5:103-134 (1990). [FR Doc. 91-5260 Filed 3-5-91; 8:45 am)
BILLING CODE 65604C" 

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