### SAT Report

PMN Number: P-15-0141
SAT Date: 12/23/2014

Print Date: 2/3/2015

Related cases : CBI : Yes
Health related cases:
Ecotox related cases:

.

Concern levels :

Type of Concern: Health Eco Comments
Level of Concern: 2 2

Persistence Bioaccum Toxicity Comments
1 11

Exposure Based Review : Health: N o Ecotox: Yes

Routes of exposure : Health: Inhalation
Ecotox: All releases to water
Fate: ;

P 2 Rec Comments : Comment: P2REC: SAT: Forward

Keywords : Keywords: LUNG; IRR/CORR-E,MM,L; AQUATOX

Summary of Assessment :

Fate : Fate Summary: FATE: Estimations for low weight Solid with MP = 59-64 C (M) log Kow = -0.51 (E) S = Dispersible / >10 g/L at 25 C (ICB / E) VP < 1.0E-6 torr at 25 C (E) BP = Dec. 270-330 C (M)H < 1.00E-8 (E) log Koc = 1.90 (E) log Fish BCF = 0.50 (E) log Fish BAF = -0.05 (E) POTW removal (%) = 50-90 via biodeg and sorption; : 46%(overall), 31%(biodeg.), 16%(sorption); >71 mg/L; 98% (10 mg/L), 99% (20 mg/L)(DOC)/34d;
84.5-85.2%/29d. Time for complete ultimate aerobic biodeg = wk-mo Sorption to soils/sediments = low
PBT Potential: P1B1 *CEB FATE: Migration to ground water = negl

Health : Health Summary: N ot absorbed through the skin, p oor absorption from the GI tract; moderate absorption from the lung . Concern for surfactant effects on the lung; irritation to eye, mucous membranes and lung based on

. Test Data: (-) Salmonella with and without activation; (-) oral mouse micronucleus assay; (-) for gene mutations in cells with and without activation; rat oral LD0 = 5000 mg/kg; rat dermal LD0 = 2000 mg/kg; N o skin irritation in the in vitro reconstituted human epidermis test; mild eye irritation in rabbits, cleared by day 7; mild eye irritant in an in
vitro ; rat 28-day oral NOEL = 650 mg/kg (highest dose tested); rat OECD 421 oral NOEL = 650 mg/kg (highest dose tested); : no skin sensitization in guinea pigs using the

Ecotox :

Test Organism Test Type Test End
Point Predicted Measured Comments

fish 96-h LC50 * daphnid 48-h LC50 * green algal 96-h EC50 *

fish

_ chronic value <4.5 daphnid

_ chronic
value <1.3 1.3

algal

_ chronic
value *

Sewage Sludge 3-h EC50

_ Sewage Sludge

_ Chronic
Value _

Ecotox Values Comments: Predictions are based on SAR nearest predictions for ); SAR chemical class = ; ; solid with mp = 50 C (M); S = 5.7 mg/L (reported as critical miscelle concentrations) anddispersible at 25 C; p H7 (M); effective concentrations based on 100% active ingredients and nominal concentrations; hardness <150.0 mg/L as CaCO3; and <2.0 mg/L;

Ecotoxicity Test Data Results for P-15-0141:
and

For P-15-0141, acute fish , short-term early life stage fish, acute daphnid, chronic daphnid, algae, earthworm, and a terrestrial plant toxicity test were submitted. Test data were also submitted for
and P-15-0141 P-15-0141
was classified as a and was considered dispersible in water soluble (critical micelle concentration = 5.7 mg/L) based on experimental data. The typical chain length composition P-15-0141 was 4.2% C16 and 94.9% and, thus, the average . The typical composition of the PMN and P-15-0141) was 0.6% C10, 61.6% C12, 20.6% C14, 8.2% C16, and 9% with an

average

.

Fish Ecotoxicity Test (P-15-0141): (1) conducted a 96-hour acute toxicity test in zebra fish with P-15-0141 (active content : 80.4% w/w) under semi-static conditions with daily renewal. This study was reported to follow OECD test guideline No. 203 (1992). Following range-finding tests, single groups of seven were exposed to a dilution water control (filtered tap water) or the PMN substance at nominal concentrations of 0.444, 0.888, 1.78, 3.55 or 7.10 mg/L. Measured concentrations of the unsaturated of the test item ranged from 14-128% of the nominal values, based on (LOQ = 2.23 μg/L of the
unsatd. of the test item). Adsorption to the glass walls in test replicates and additional replicates without fish ranged from 3-13% of nominal concentrations of the
unsaturated . A stock solution was prepared via direct weighing of the test substance. In addition, according to the deviation field on was added to the stock solution, but no further details are provided regarding the quantity of the addition. The test media were mixed with an for 1 minute at 17000 rpm. The test vessels were loosely covered with glass tops. The test concentrations were clearly solved throughout exposure, with the exception of the 3.55 and 7.10 mg/L solutions at 24 hours, in which turbidity was caused by microbial degradation of dead fish. Over the course of testing, temperature ranged from 22.6-24.2°C, p H ranged fro m 7.09-7.47 and dissolved oxygen ranged from 90-100%. The dilution water hardness was 53.8 mg CaCO3/L. A loading rate of 0.83 g fish/L was reported. The % mortality at 0 (control), 0.444, 0.888, 1.78, 3.55 and 7.10 mg/L was 0, 0, 0, 0, 100 and 100%, respectively. Quiescence and abnormal swimming motions were observed at 1.78 and 3.55 mg/L; unusually long arresting on the ground was observed at 1.78 mg/L. Based on nominal concentrations with adjustment for 80.4% , the 96-hour LC50 was 2.02 mg L. The study was acceptable even though there are concerns with the suggestion that a solvent may have been added to the test system considering data available for a

. 96-hour LC50 = 2.02 mg/L

(2) conducted a short-term toxicity test on embryo and sac-fry stagesin zebra fish ( with P-15-0141 (active content: 80.4% w/w) under semi-static conditions with renewal of the test media every 2 to 3 days. This study was reported to follow OECD test guideline No. 212 (1998). Following a preliminary range-finding test, three replicates of eggs were exposed to a dilution water control (filtered tap water) or the test substance at nominal concentrations of 0.044, 0.0888, 0.178, 0.355 or 0.710 mg/L for 9 days (5 days post-hatch). Measured concentrations of the unsatd. of the test item ranged from < LOQ to 111% of the nominal values, based on (LOQ = 2.23 μg/L of
unsatd. of the test item). Adsorption to the glass walls in additional replicates ( p repared without eggs) ranged from <LOQ to 17% of nominal concentrations of the unsatd. . A stock solution of 1.00 mg/L was freshly prepared with dilution water. In addition, according to the deviation field on p.20, was added to the stock solution, but no further details are provided regarding the quantity of the addition. Other test concentrations were

p repared from this stock solution by dilution. Dispersion of the test substance was achieved through agitation. Over the course of testing, temperature ranged from 24.3-26.0°C, p H range d from 7.02-7.61 and dissolved oxygen ranged from 94-100%. The total hardness, measured at the beginning of the exposure from one replicate per test concentration and control, was in the range of 50-53 mg CaCO3/L. The of the dilution water was 1.28 mg/L. The % mortality at 0 (control), 0.044, 0.088, 0.178, 0.355 and 0.710 mg/L was 0, 0, 3, 3, 3 and 60%, respectively. The egg fertilization rate, determined on study day 0 (start of exposure) was ≥ 98%. The percent egg hatch and overall survival was significantly reduced in the 0.710 mg/L group. There were no significant effects on the percent swim-up of hatched fry, p ost hatch success, fry growth. On study day 5 and 6 some larvae of the 0.710 mg/L group showed side position and edema and from study days 6 to 9 (end of the study) some larvae of this group showed marked by abnormally low activity. The reported effect levels are based on the nominal concentrations with adjustment for 80.4% . The 9-day LC50- was 0.538 mg/L. For the parameters of post-hatch survival, length and dry weight, the was 0.571 mg/L, the highest test concentration. For the parameters of hatch and overall survival, the and values were 0.285 mg/L and 0.571 mg/L, respectively. The corresponding for hatch and overall survival was calculated to be 0.403 mg/L. Considering the nature of the study, not all life stages are represented and thus, the study does not fully characterize the fish early life stage endpoint that is used in New Chemicals screening assessments. However, the study was conducted correctly according to a OECD recommended guideline and it does suggest concerns for certain early life stages and, thus, in the absence of a full early-life stage test it is considered to best represent chronic population level hazard concerns for fish. 9-day LC50 = 0.538 mg/L ( p ost hatch survival, length, dry weight) = 0.571 mg /L (hatch, overall survival) = 0.285 mg/L (hatch, overall survival) = 0.571 mg/L (hatch, overall survival) = 0.403 mg/L

Daphnid Ecotoxicity Test (P-15-0141): (1) conducted a 48-hour acute immobilization test in with P-15-0141 (active content : 80.4% w/w) under semi-static conditions with renewal at 24 hours. This study was reported to follow Following

p reliminary tests, four replicates of five were exposed to a dilution water control test water) or the test substance at nominal concentrations of 0.710, 1.26, 2.25, 3.99 or 7.10mg/L. Measured concentrations of the of the test item ranged from 58-108%, based on of of the test item). Adsorption to the glass walls in separate replicates without ranged from 6-21%
of nominal concentrations of the . The stock solution (7.10 mg/L of the test item were weighed out) was freshly prepared with dilution water prior to each exposure interval.
The stock solution was treated with ultrasound for 30 minutes at 40°C. The stock solution was then diluted in order to obtain the required nominal concentrations. The test vessels were loosely covered. All test item concentrations were visually clear throughout the exposure period. Over the course of testing, the temperature in the incubator was 19-20°C, p H ranged fro m 7.29-8.19 and dissolved oxygen ranged from 7.59-9.13 mg/L. The dilution water hardness ranged from 247-262 mg CaCO3/L, which is considered high. A loading rate of 250 /L was calculated, which is high and may have resulted in crowding. The % immobilization at 0 (control), 0.710, 1.26, 2.25, 3.99 and 7.10 mg/L was 0, 10, 90, 100, 100 and 100%, respectively. The 48-hour adjusted for the 80.4% was 0.8 mg/L. The study was acceptable. 48-hour = 0.8 mg/L

(2) conducted a 21-day reproduction test in with P-15-0141 (active content : 80.4% w/w) under semi-static conditions with daily renewal. This study was reported to follow Ten replicates containing a single were exposed to a dilution water control or the test substance at nominal concentrations of 0.0625, 0.125, 0.250, 0.500 or 1 mg test item/L. Measured
concentrations of the of the test item ranged from 40-119%, as determined by (LOQ = 2.23 μg/L of of the test item). Adsorption to the glass walls in separate replicates without ranged from 3-23% of nominal
concentrations of the . A stock solution (1.00 mg/L of the test item were weighed out) was freshly prepared with dilution water for each exposure interval. The stock solution was treated with ultrasound for 30 minutes at 40°C. The test vessels were loosely covered with a watch glass. Water quality parameters were measured in the control and 1000 μg/L solutions. Over the course of testing, temperature ranged from19.0-22.0°C, p H range d from 7.16-7.88, dissolved oxygen ranged from 6.70-8.98 mg/L and total hardness ranged from 160-178 mg CaCO3/L. The pH level was considered slightly high. A loading rate of 20
was calculated. N o significant adult mortality (> 20%) was observed. The %

p arental mortality at 0 (control), 0.0625, 0.125, 0.250, 0.500 and 1 mg test item/L was 0, 0, 0, 10, 10 and 20%, respectively. At 1 mg/L, the following statistically significant effects were observed: decreased mean number of living juveniles per producing parental increased coefficient of variation of the mean number of juveniles per producing parent; decreased mean intrinsic rates of natural increase of the surviving parental ; decreased mean number of broods with living juveniles and increased percentage of dead juveniles relation to the total number of produced juveniles. At 0.5 mg/L, the mean number of living juveniles per producing

p arental was statistically significantly decreased. N o males or ephippia (winter eggs) were observed in the control or in the test groups. The reported effect levels are based on the nominal concentrations with adjustment for percentage . The 21-day for adult mortality adjusted for 80.4% was 0.804 mg /L. The 21-day EC50 for reproduction adjusted for 80.4% was 0.474 mg/L. The 21-day and for reproduction adjusted for 80.4% were 0.201 mg /L and 0.402 mg/L, respectively. The 21-day for reproduction adjusted for 80.4% was calculated to be 0.284 mg/L. Thevariable ‘total number of living offspring produced at the end of the test per parent at the start of the test’ was not calculated; due to parental mortality in the 0.25, 0.5, and 1 mg/L groups this variable may impact the determined effect level for this study. Based on an interpretation of the numbers provided by the submitter, if this calculation had been provided as indicated in OECD guidelines, the and may have been 0.101 mg/L and 0.201 mg/L, respectively. Thus, these values will be used for risk determination unless the submitter

p rovides this calculated variable. Besides this missing calculation, the study was considered acceptable. 21-day (adult mortality) = 0.804 mg/L 21-day (#young/replicate) = 0.101 mg/L 21-day (#young/replicate) = 0.201 mg/L 21-day (#young/replicate) = 0.142 mg/L

Daphnid Ecotoxicity Test /141): (1) conducted a 48-hour acute immobilization test in Daphnia magna
with a and P-15-0141( p urity: 91.9% under static conditions. This study was reported to follow ). Following a range-finding test, four replicates of five were exposed to a dilution water control test water) or the test substance at nominal concentrations of 1.25, 2.50, 5.00, 10.0 or 20.0 mg/L (equivalent to 1.15, 2.30, 4.60, 9.19 and 18.38 mg/L as active components (91.9% w/w)). Analytical evaluation of the main components of the test item, and , was carried out via (LOQ = 30.0 μg test item/L; corresponding to
17.0 /L and 5.67 /L). Measured concentrations of the component ranged from 96-117% of nominal values. Measured concentrations of
the component ranged from 71-116% of nominal values. A 20.0 mg/L stock solution was prepared with dilution water. The stock solution was treated with ultrasound for 30 minutes at 40°C. Test item concentrations were then prepared by diluting the stock solution. The test vessels were loosely covered with watch glasses. All test item concentrations were visually clear throughout the exposure period. At the end of the exposure (48 h), white flakes were observed at the bottom of the test vessels of the 10.0 and 20.0 mg/L concentration levels. Over the course of testing, temperature was maintained at 18-22° (constant within ±1°C), p H range d from 6.95-7.67 and dissolved oxygen ranged from 7.69-8.86 mg/L. The dilution water hardness was 263 mg CaCO3/L, which is high by standards. A loading rate of 250 daphnids/L was calculated, which is high by EPA standards and may result in crowding. The % immobilization at 0 (control), 1.25, 2.50, 5.00, 10.0 and 20.0 mg/L was 0, 0, 0, 15, 70 and 85%, respectively. Based on nominal concentrations of the active components , the 48-hour was 7.06 mg/L. The study was considered acceptable. 48-hour = 7.06 mg/L

(2) conducted a 21-day reproduction test in with a and P-15-0141 ( p urity: 91.9% ) under semi-static conditions with renewal three times per week (every 48 or 72 hours). This study was reported to follow . Ten replicates of individual were exposed to a
dilution water control ) or the test substance at nominal concentrations of 0.500, 1.00, 2.00, 4.00 or 8.00 mg/L (equivalent to 0.460, 0.919, 1.84, 3.68 and 7.35 mg/L as active components (91.9% w/w)). Analytical evaluation of the maincomponents of the test item, and , was carried out via test item/L; corresponding to 17.0 /L and 5.69 μg
. Measured concentrations of ranged from 90-114% of
nominal values. Measured concentrations of ranged from 64-109% of nominal values. An 8.00 mg/L stock solution was freshly prepared with dilution water for each exposure
interval. The stock solution was treated with ultrasound for 30 minutes at 40°C. The test item concentrations were then prepared by diluting the stock solution. The test vessels were loosely covered with a glass watch. Over the course of testing, temperature ranged from 21.1-22.0°C, p H ranged from 6.93-7.68 and dissolved oxygen ranged from 6.11-8.86 mg/L. The total hardness of the water, based on measurements in the control and test solutions, ranged from 161-190 mg CaCO3/L. A loading rate of 20 /L was calculated. N o statistically significant
treatment-related effects were observed on the coefficient of variation of the mean number of j uveniles per producing parent, the first appearance of living juveniles, p ercentage of dead j uveniles related to the total number of juveniles, and body length and body weight of parental

. N o males or ephippia (winter eggs) were observed in the control or in the test groups during the test. The % p arental mortality at 0 (control), 0.500, 1.00, 2.00, 4.00 and 8.00 mg/L was 0, 0, 0, 10, 10 and 100%, respectively. The submitter did not calculate the variable ‘total number of living offspring produced at the end of the test per parent at the start of the test’, which is considered more representative of population level concerns. Based on an interpretation of the numbers provided by the submitter, if this calculation had been provided as
indicated in , the and would have likely been 0.919 mg/L and 1.84 mg/L, respectively. In the absence of these calculations from the submitter, the above estimates will be used for risk determination. Submitter provided calculations that related j uveniles produces per surviving parent daphnid indicate that at 4.00 mg/L, statistically significant decreases were observed in the mean number of living juveniles per producing

p arental , mean intrinsic rates of natural increase and mean number of broods with living j uveniles. Based on nominal concentrations of the active components , the 21-day EC50 for adult mortality was 4.73 mg /L and the 21-day EC50 for reproduction was
3.68-7.35 /L. The 21-day and values for reproduction were 1.84
and 3.68 /L, respectively, based on total number of juveniles per parent at the start of the test. The study was considered acceptable. 21-day LC50 = 4.73 mg/L 21-day = 0.919 mg/L (#young/replicate) 21-day = 1.84 mg/L (#young/replicate) 21-day = 1.3 mg/L (#young/replicate)

Algal Ecotoxicity Test (P-15-0141): conducted a 72-hour algal growth inhibition test in green algae ) with P-15-0141 ( p urity: 100%; active content: 80.4% w/w) under static conditions. This study was reported to follow Following a range-finding test, six replicates of (4864 cells/mL) were exposed to a dilution water control and three replicates were exposed to the test substance at nominal concentrations of 5, 10, 20, 40 or 80 mg/L. Measured concentrations of the of the test item ranged from 72-108% of nominal values, based on (
of of the test item). The algae were illuminated at a light intensity of 66.1-81.8 with constant shaking. A stock solution of 80.0 mg/L wasfreshly prepared with dilution water. Dispersion of the test substance was achieved through agitation. The stock solution was then diluted to obtain the required nominal concentrations. Test vessels were sealed with cotton wool plugs. Over the course of testing, temperature ranged from 23.0-24.0°C and pH ranged from 8.12-8.59. The mean cell density in control cultures increased by a factor of 303 within 72 hours. The 72-hour EC50 adjusted for 80.4% was greater than 64.3 mg /L for growth rate and yield inhibition. The 72-hour adjusted for 80.4% was 64.3 mg /L, the highest test concentration. Considering the critical concentration of 5.7 mg/L, results could be interpreted as no effects at saturation. The study was considered acceptable 72-hour > 64.3 mg /L or NES (growth rate and yield) 72-hour = 64.3 mg/L or NES (growth rate and yield)

Earthworm Ecotoxicity Test (P-15-0141): conducted a 56-day reproduction test in earthworms (Eisenia fetida) with P-15-0141 ( p urity: 100%; active content: 80.4% w/w) under static conditions. This study was reported to follow . Following a preliminary study, four replicates of ten E. fetida were exposed to test substance at nominal concentrations of 62.5, 125, 250, 500 and 1000 mg/kg dry soil weight. Eight replicates of ten E. fetida were exposed to a control treatment (artificial soil moistened with demineralized water). The artificial soil used in this study consisted of the following components: 10% air-dried and finely ground peat; 20% ; 69% ; 40% . Two days prior to testing, the artificial soil was brought to 26% of the maximal water capacity through the addition of demineralized water. To prepare the test concentrations, appropriate amounts of test item were weighed out, then demineralized water was added and stirred at 50oC for one hour. The spiking solutions and additional demineralized water were added to the artificial soil to adjust its humidity to a moisture of 52% of the maximum water holding capacity. Subsequently, the test medium was thoroughly mixed to ensure a homogenous distribution and about 600 g soil dry weight were filled into test vessels. Test containers were covered with transparent and perforated lids to prevent the test medium from drying, whilst allowing gaseous exchange. The water content of the soil substrate in the test containers were maintained throughout the test by re-weighing the test containers once a week. Losses were replenished as necessary with deionized water. After the first 4 weeks of the test, mortality and biomass of the adult worms were determined. After further 4 weeks, the reproduction rate was determined by counting the hatched juveniles. Over the course of the study, room temperature ranged from 18.0-23.0oC. The

p H of the artificial soil ranged from 6.42-6.64. The average moisture content ranged from 24.8-33.1% of dry weight. After 28 days of exposure, no mortality, p athological symptoms o r changes in behavior were observed in the control and treatment groups. Exposure to the test substance did not affect adult earthworm biomass. After 56 days, the reproductive rate (average number of juveniles produced) was 176 in the control and ranged between 138-166 in the treatment groups, respectively. Compared to the control, no statistically significant reduction of reproduction was observed at all test item concentrations. Based on nominal concentrations, the 28-day was 1000 mg/kg dry soil weight for mortality and biomass. The 56-day could not be determined for reproduction since no effects were observed; the 56-day C was 1000 mg/kg dry soil weight for reproduction. Although the study appears acceptable, the earthworm toxicity test is not generally used in the screening level assessment for new chemicals due to limited terrestrial exposure information.28-day NOEC (mortality and biomass) = 1000 mg/kg dry soil weight 56-day NOEC (reproduction) = 1000 mg/kg dry soil weight

Terrestrial Plant Toxicity Test (P-15-0141): conducted a 21-day seedling emergence and growth test with oats ), rape ), and soybean ). This study was reported to follow OECD test guideline No. 208. Following preliminary testing, eight replicates of each species (5 seeds/replicate) were exposed to an untreated soil control (2:1 mixture of natural soil and quartz sand; p H = 5.48) or P-15-0141 ( p urity: 100%; active content: 80.4% w/w) at nominal concentrations of 62.5, 125, 250, 500, or 1000 mg/kg soil dry weight. To prepare the treated soil, appropriate amounts of test substance were weighed out for each test item concentration.
Demineralized water was then added to the test substance and this test solution was stirred at approximately 50oC for 1 hour on a magnetic stirrer. Afterwards, the test item solution and an appropriate amount of demineralized water (adjusting the soil to a moisture of 50% the maximum water holding capacity) was added to the soil. Subsequently, the soil was mixed carefully to ensure homogenous distribution. Over the course of the study, the temperature ranged from 16.0-21.0oC, relative humidity ranged from 60-100% and light intensity was 4524 ± 660 lux. After 21 days no test item related phytotoxic effects were determined for all tested plant species up to the test concentration 1000 mg/kg soil dry weight. Based on nominal concentrations, the 21-day was > 1000 mg/kg soil dry weight for all parameters (shoot height; shoot fresh weight; rate of emergence) for all species tested (oats, rape, soybean). Based on shoot height and rate of emergence, the was reported to be 1000 mg/kg soil dry weight for all species. Based on shoot fresh weight, the C and values for oats and soybean were 500 and 1000 mg/kg soil dry weight, respectively; the was calculated to be 707 mg/kg soil dry weight. Based on shoot fresh weight, the and values for rape were 250 and 500 mg/kg soil dry weight, respectively; the was calculated to be 354 mg/kg soil dry weight. Although the study appears acceptable, the terrestrial plant toxicity test is not generally used in the screening level assessment for new chemicals due to limited terrestrial exposure
information.
Oats ): 21-day (shoot height, shoot fresh weight, rate of emergence) > 1000 mg/kg soil dry weight 21-day (shoot height, rate of emergence) > 1000 mg/kg soil dry weight 21-day (shoot fresh weight) = 500 mg/kg soil dry weight 21-day (shoot fresh weight) = 1000 mg/kg soil dry weight 21-day (shoot fresh weight) = 707 mg/kg soil dry weight

Rape ( ): 21-day (shoot height, shoot fresh weight, rate of emergence) > 1000 mg/kg soil dry weight 21-day (shoot height, rate of emergence) > 1000 mg/kg soil dry weight 21-day (shoot fresh weight) = 250 mg/kg soil dry weight 21-day (shoot fresh weight) = 500 mg/kg soil dry weight 21-day (shoot fresh weight) = 354 mg/kg soil dry weight

Soybean ( ): 21-day 0 (shoot height, shoot fresh weight, rate of emergence) > 1000 mg/kg soil dry weight 21-day (shoot height, rate of emergence) > 1000 mg/kg soil dry weight21-day (shoot fresh weight) = 500 mg/kg soil dry weight 21-day (shoot fresh weight) = 1000 mg/kg soil dry weight 21-day (shoot fresh weight) = 707 mg/kg soil dry weight

Conclusion: Submitted studies were acceptable. Since are like the current PMN, any new data were incorporated into the structure activity relationships developed in ’ 91 and concern concentrations were derived from these. Bolded values represent those effect levels supported by experimental data.

[Table provided in attachment.]

For P-15-0141, an acute of 0.16 mg/L (160 p pb) was calculated from the 48-hour ) of 0.8 mg/L with application of an assessment factor of 5 to account for species sensitivity distributions and inter-/intra- laboratory variability. A chronic of 0.014 mg/L (14 p pb) was calculated from the experimental of 0.142 mg/L with application of an assessment factor of 10 to represent species sensitivity distributions and inter-/intra- laboratory variability.

Acute 160 p pb
Chronic : 14 p pb

Reviewer: K.Moran

Factors Values Comments

Assessment Factor
10
Concentration of Concern ( p pb) 14

SARs
SAR Class Ecotox Category

Ecotox Factors Comments:

SAT Chair: L Keifer 564-8916