##### Table of Contents




United States


Securities and Exchange Commission


Washington, D.C. 20549





---




Form 10-Q





QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF


THE SECURITIES EXCHANGE ACT OF 1934





For the quarterly period ended June 30, 2002





Commission file number 000-28401














MAXYGEN, INC.


(Exact name of
registrant as specified in its charter)





Delaware (State of
incorporation)

77-0449487 (I.R.S. Employer
Identification No.)





515 Galveston Drive


Redwood City, California 94063


(Address of principal executive offices, including zip code)








(650) 298-5300


(Registrants telephone number, including area code)





---




Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.





Yes
X            No





As of August 1, 2002, there were 34,310,308 shares of the registrants common stock outstanding.




1




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##### Table of Contents




MAXYGEN, INC.


FORM 10-Q


QUARTER ENDED
JUNE 30, 2002





INDEXPart I

FINANCIAL INFORMATIONItem 1:

Unaudited Financial Statements:Condensed Consolidated Balance Sheets as of December 31, 2002 and June 30, 2002

3Condensed Consolidated Statements of Operations for the three and six month periods ended June 30, 2001 and 2002

4Condensed Consolidated Statements of Cash Flows for the six month periods ended June 30, 2001 and 2002

5Notes to Condensed Consolidated Financial Statements

6Item 2:

Managements Discussion and Analysis of Financial Condition and Results of Operations

13Item 3:

Quantitative and Qualitative Disclosures About Market Risk

30Part II

OTHER INFORMATIONItem 1:

Legal Proceedings

31Item 2:

Changes in Securities and Use of Proceeds

31Item 3:

Defaults Upon Senior Securities

31Item 4:

Submission of Matters to a Vote of Security Holders

32Item 5:

Other Information

32Item 6:

Exhibits and Reports on Form 8-K

32SIGNATURES

33




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##### Table of Contents

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Part I  Financial Information


ITEM 1


FINANCIAL STATEMENTS





MAXYGEN, INC.


CONDENSED CONSOLIDATED BALANCE SHEETS


(in thousands, except share and per share amounts)





December 31, 2001


June 30, 2002(Note 1)


(unaudited)ASSETSCurrent assets:Cash and cash equivalents

$
48,388


$
109,034Short-term investments


157,557



109,880Grant and other receivables


7,300



9,243Prepaid expenses and other current assets


2,279



3,175Total current assets


215,524



231,332Property and equipment, net


17,340



17,339Goodwill


12,192



12,192Intangible assets, net of accumulated amortization of $1,593 at December 31, 2001 and $2,165 at June 30, 2002,
respectively


1,842



1,270Long-term investments


28,932



2,540Investment in joint venture






771Deposits and other assets


1,588



1,456Total assets

$
277,418


$
266,900LIABILITIES AND STOCKHOLDERS EQUITYCurrent liabilities:Accounts payable

$
3,398


$
1,828Accrued compensation


2,355



3,670Accrued legal expenses


815



1,084Deferred rent


937



1,025Other accrued liabilities


2,381



2,484Deferred revenue


9,093



10,404Current portion of equipment financing obligations


622



660Total current liabilities


19,601



21,155Deferred revenue


3,410



2,497Non-current portion of equipment financing obligations


673



333Commitments and contingenciesStockholders equity:Preferred stock, $0.0001 par value, 5,000,000 shares authorized, no shares issued and outstanding at December 31, 2001
and June 30, 2002






Common stock, $0.0001 par value: 100,000,000 shares authorized, 34,026,414, and 34,248,858 shares issued and outstanding
at December 31, 2001 and June 30, 2002, respectively


3



3Additional paid-in capital


389,607



391,711Notes receivable from stockholders


(339
)


(262
)Deferred stock compensation


(8,509
)


(4,472
)Accumulated other comprehensive income


1,698



2,365Accumulated deficit


(128,726
)


(146,430
)Total stockholders equity


253,734



242,915Total liabilities and stockholders equity

$
277,418


$
266,900





See accompanying notes.




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##### Table of Contents




MAXYGEN, INC.


CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS


(in thousands, except per share data)


(unaudited)





Three Months ended June
30,


Six Months ended June
30,2001


2002


2001


2002Collaborative research and development revenue

$
5,972


$
9,294


$
10,997


$
17,309Grant revenue


1,704



1,220



3,609



2,545Total revenues


7,676



10,514



14,606



19,854Operating expenses:Research and development


13,031



15,381



25,727



30,352General and administrative


3,952



3,185



7,500



6,249Stock compensation expense (1)


3,512



1,951



7,055



4,128Amortization of goodwill and other intangible assets


2,182



286



4,363



572Total operating expenses


22,677



20,803



44,645



41,301Loss from operations


(15,001
)


(10,289
)


(30,039
)


(21,447
)Interest income, net


3,455



1,807



7,429



3,972Equity in net loss of joint venture






(229
)






(229
)Net loss

$
(11,546
)

$
(8,711
)

$
(22,610
)

$
(17,704
)Basic and diluted net loss per share

$
(0.35
)

$
(0.26
)

$
(0.70
)

$
(0.53
)Shares used in computing basic and diluted net loss per share


32,534



33,385



32,359



33,269(1)     Stock compensation expense related
to the following:Research and development

$
2,875


$
1,511


$
5,751


$
3,092General and administrative


637



440



1,304



1,036$
3,512


$
1,951


$
7,055


$
4,128





See accompanying notes.




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##### Table of Contents




MAXYGEN, INC.


CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS


(in thousands)


(unaudited)





Six Months ended June
30,2001


2002Operating activitiesNet loss

$
(22,610
)

$
(17,704
)Adjustments to reconcile net loss to net cash used in operating activities:Depreciation and amortization


1,333



2,537Amortization of intangible assets


4,363



572Equity in net loss of joint venture






229Non-cash stock compensation


6,899



4,037Common stock issued and stock options granted to consultants for services rendered


360



925Changes in operating assets and liabilities:Grant and other receivables


1,101



(1,943
)Prepaid expenses and other current assets


(469
)


99Deposits and other assets


(208
)


(156
)Accounts payable


(19
)


(1,570
)Accrued liabilities and deferred rent


2,952



1,775Deferred revenue


2,315



398Net cash used in operating activities


(3,983
)


(10,801
)Investing activitiesPurchases of available-for-sale securities


(121,332
)


(18,877
)Maturities of available-for-sale securities


87,543



91,671Investment in joint venture






(1,000
)Acquisition of property and equipment


(3,348
)


(2,057
)Net cash (used in) provided by investing activities


(37,137
)


69,737Financing activitiesRepayments under equipment financing obligation


(249
)


(302
)Equity adjustment from foreign currency translation


(972
)


756Proceeds from issuance of common stock


1,357



1,179Payments received on promissory notes






77Net cash provided by financing activities


136



1,710Net increase in cash and cash equivalents


(40,984
)


60,646Cash and cash equivalents at beginning of period


111,374



48,388Cash and cash equivalents at end of period

$
70,390


$
109,034





See accompanying notes.




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##### Table of Contents




MAXYGEN, INC.


NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS


(unaudited)





1.    Basis of Presentation and Significant
Accounting Policies





Basis of Presentation





The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with generally accepted accounting principles for interim financial information. The information
as of June 30, 2002 and for the three months and six months ended June 30, 2001 and June 30, 2002 includes all adjustments (consisting only of normal recurring adjustments) that the management of Maxygen, Inc. (Maxygen or the
Company) believes necessary for fair presentation of the results for the periods presented.





Results for any interim period
are not necessarily indicative of results for any future interim period or for the entire year. The accompanying condensed consolidated financial statements should be read in conjunction with the financial statements and notes thereto included in
the Companys Report on Form 10-K for the year ended December 31, 2001.





Principles of Consolidation





The condensed consolidated financial statements include the accounts of the Company and its subsidiaries. All significant intercompany balances and transactions
have been eliminated in consolidation.





Revenue Recognition





Non-refundable up-front payments received in connection with research and development collaboration agreements, including technology advancement funding that is intended for the development of the
Companys core technology, are deferred and recognized on a straight-line basis over the relevant periods specified in the agreement, generally the research term.





Revenue related to collaborative research with the Companys corporate collaborators is recognized as research services are performed over the related funding periods for each contract. Under
these agreements, the Company is required to perform research and development activities as specified in each respective agreement. The payments received under each respective agreement are not refundable and are generally based on a contractual
cost per full-time equivalent employee working on the project. Research and development expenses under the collaborative research agreements approximate or exceed the research funding revenue recognized under such agreements over the term of the
respective agreements. Deferred revenue may result when the Company does not incur the required level of effort during a specific period in comparison to funds received under the respective contracts. Payments received related to substantive,
at-risk incentive milestones, if any, are recognized as revenue upon achievement of the incentive milestone event because the Company has no future performance obligations related to the payment. Incentive milestone payments are triggered either by
the results of the Companys research efforts or by events external to the Company, such as regulatory approval to market a product. Royalties are recorded as earned in accordance with the contract terms when third party results are reliably
measured and collectibility is reasonably assured.





The Company was awarded grants from the Defense Advanced Research Projects Agency,
National Institute of Standards and Technology-Advanced Technology Program, the U.S. Agency for International Development and the U.S Army Medical Research and Material Command for various research and development projects. The terms of these grant
agreements are three years with various termination dates, the last of which is June 2005 for existing agreements. Revenue related to grant agreements is recognized as related research and development expenses are incurred.




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##### Table of Contents




Net loss per share





Basic and diluted net loss per common share are presented in conformity with the Statement of Financial Accounting Standards No. 128, Earnings per Share (SFAS 128), for all
periods presented. In accordance with SFAS 128, basic and diluted net loss per share has been computed using the weighted-average number of shares of common stock outstanding during the period, less shares subject to repurchase.





The following table presents the calculation of basic and diluted net loss per share (in thousands, except per share data):





Three Months ended June
30,


Six Months ended June
30,2001


2002


2001


2002Net Loss

$
(11,546
)

$
(8,711
)

$
(22,610
)

$
(17,704
)Basic and diluted:Weighted-average shares of common stock outstanding


33,832



34,185



33,744



34,130Less: weighted-average shares subject to repurchase


(1,298
)


(800
)


(1,385
)


(861
)Weighted-average shares used in computing basic and diluted net loss per share


32,534



33,385



32,359



33,269Basic and diluted net loss per share

$
(0.35
)

$
(0.26
)

$
(0.70
)

$
(0.53
)





The Company has excluded all outstanding stock options, outstanding warrants and shares
subject to repurchase from the calculation of diluted loss per common share because all such securities are antidilutive for all applicable periods presented. The total number of shares excluded from the calculations of diluted net loss per share,
prior to application of the treasury stock method for options, was 8,132,000 at June 30, 2001 and 8,931,000 at June 30, 2002. Such securities, had they been dilutive, would have been included in the computations of diluted net loss per share along
with restricted common stock subject to the Companys right of repurchase.





Comprehensive Income (Loss)





Comprehensive income (loss) is primarily comprised of net unrealized gains or losses on available-for-sale securities and foreign currency translation
adjustments. Comprehensive income (loss) and its components for the three month and six month periods ended June 30, 2001 and June 30, 2002 were as follows (in thousands):





Three Months ended June
30,


Six Months ended June
30,2001


2002


2001


2002Net loss

$
(11,546
)

$
(8,711
)

$
(22,610
)

$
(17,704
)Changes in unrealized gain (loss) on securities available-for-sale


226



(225
)


781



(1,275
)Changes in foreign currency translation adjustments


(1,158
)


2,107



(1,233
)


1,942Comprehensive loss

$
(12,478
)

$
(6,829
)

$
(23,062
)

$
(17,037
)




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##### Table of Contents




The components of accumulated other comprehensive income (loss) were as follows (in thousands):





December 31, 2001


June 30, 2002Unrealized gains on securities available-for-sale

$
1,791


$
516Foreign currency translation adjustments


(93
)


1,849Accumulated other comprehensive income

$
1,698


$
2,365





Recent Accounting Pronouncements





In October 2001, the Financial Accounting Standards Board issued Statement of Financial Accounting Standards No. 144, Accounting for the Impairment or Disposal
of Long-Lived Assets (Statement 144), which addresses financial accounting and reporting for the impairment or disposal of long-lived assets and supersedes Statement 121, Accounting for the Impairment of Long-Lived Assets and for Long-Lived Assets
to be Disposed Of, and the accounting and reporting provisions of APB Opinion No. 30, Reporting the Results of Operations for a disposal of a segment of a business. The Company adopted Statement 144 on January 1, 2002, and has determined that the
Statement does not have a significant impact to the Companys financial position or results of operations.





2.    Investments





Management determines the appropriate classification of debt securities at
the time of purchase and reevaluates such designation as of each balance sheet date. The Companys debt securities are classified as available-for-sale and are carried at estimated fair value in cash equivalents and investments. Unrealized
gains and losses are reported as accumulated other comprehensive income (loss) in stockholders equity. The amortized cost of debt securities in this category is adjusted for amortization of premiums and accretion of discounts to maturity. Such
amortization is included in interest income. Realized gains and losses on available-for-sale securities and declines in value deemed to be other-than temporary, if any, are included in interest income and expense. The cost of securities sold is
based on the specific identification method. Interest and dividends on securities classified as available-for-sale are included in interest income. The Companys cash equivalents and investments as of June 30, 2002 are as follows (in
thousands):





Amortized Cost


Gross Unrealized Gains

Gross Unrealized Losses


Estimated Fair ValueMoney market funds

$
109,034


$


$



$
109,034Corporate bonds


111,904



535


(19
)


112,420Total


220,938



535


(19
)


221,454Less amounts classified as cash equivalents


(109,034
)









(109,034
)Total investments

$
111,904


$
535

$
(19
)

$
112,420





Realized gains or losses on the sale of available-for-sale securities for the three month
and six month periods ended June 30, 2001 and June 30, 2002 were insignificant.





At June 30, 2002, the contractual maturities of
investments were as follows (in thousands):





Amortized Cost

Estimated Fair ValueDue within one year

$
109,360

$
109,880Due after one year


2,544


2,540$
111,904

$
112,420




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##### Table of Contents




3.    Intangible Assets





In July 2001, the Financing Accounting Standard Board issued Statement of Financial Accounting Standards (referred to as SFAS) No. 141, Business Combinations and SFAS No. 142,
Goodwill and Other Intangible Assets. SFAS 141 specifies criteria that intangible assets acquired in a purchase business combination must meet to be recognized and reported apart from goodwill, noting that any purchase price allocable to
an assembled workforce may not be accounted for separately. SFAS 142 requires, among other things, that the assembled workforce be reclassified to goodwill and that goodwill (including assembled workforce) and intangible assets with indefinite lives
no longer be amortized, but instead be tested for impairment at least annually in accordance with SFAS 142. The Company has no intangible assets with indefinite lives. SFAS 142 also requires that intangible assets with definite useful lives be
amortized over their respective useful lives to their estimated residual values, and reviewed for impairment in accordance with SFAS 144, Accounting for the Impairment or Disposal of Long-Lived Assets. The Company adopted the provisions
of SFAS 141 and SFAS 142 effective January 1, 2002.





SFAS 141 provides that, upon adoption of SFAS 142, the Company is required to
evaluate existing intangible assets and goodwill that were acquired in a purchase business combination prior to June 30, 2001, and make necessary reclassifications to conform with the new criteria in SFAS 141. As a result, the Company reclassified
assembled workforce with a net carrying value of $378,000 to goodwill on January 1, 2002.





Upon adoption of SFAS 142, the Company
reassessed the useful lives and residual values of all intangible assets (excluding goodwill and assembled workforce) acquired in purchase business combinations. No adjustments to amortization periods were necessary.





The provisions of SFAS 142 also require the completion of a transitional impairment test within six months of adoption, with any impairments treated as a
cumulative effect of change in accounting principle. During the quarter ended June 30, 2002, the Company completed the transitional impairment test, which did not result in impairment of recorded goodwill.





In addition, the Company must perform an impairment test at least annually. Any impairment loss from the annual test will be recognized as a part of operations.





A reconciliation of reported net loss to adjusted net loss, as if SFAS 142 had been implemented as of January 1, 2002, is as follows (in
thousands, except per share data):





Year ended December 31,


Three Months ended June
30,


Six Months ended June
30,1999


2000


2001


2001


2002


2001


2002Reported net loss

$
(13,518
)

$
(59,585
)

$
(44,964
)

$
(11,546
)

$
(8,711
)

$
(22,610
)

$
(17,704
)Add back: goodwill (incl. assembled workforce) amortization






2,970



7,581



1,895







3,791



Adjusted net loss

$
(13,518
)

$
(56,615
)

$
(37,383
)

$
(9,651
)

$
(8,711
)

$
(18,819
)

$
(17,704
)Basic and diluted net loss per share:Reported net loss

$
(1.53
)

$
(1.96
)

$
(1.38
)

$
(0.35
)

$
(0.26
)

$
(0.70
)

$
(0.53
)Goodwill (incl. assembled workforce) amortization






0.10



0.23



0.06







0.12



Adjusted net loss

$
(1.53
)

$
(1.86
)

$
(1.15
)

$
(0.29
)

$
(0.26
)

$
(0.58
)

$
(0.53
)




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##### Table of Contents




Intangible assets subject to amortization consist of purchased core technology as follows (in
thousands):





December 31,


June 30, 20022000


2001Gross Carrying Value

$
3,435


$
3,435


$
3,435Accumulated amortization


(448
)


(1,593
)


(2,165
)Net Carrying Value

$
2,987


$
1,842


$
1,270





Aggregate amortization expense is as follows (in thousands):





For the year ended December 31, 2000 (actual)

$
448For the year ended December 31, 2001 (actual)

$
1,145For the six months ended June 30, 2002 (actual)

$
572For the remaining six months in the year ended December 31, 2002 (estimated)

$
572For the year ended December 31, 2002 (estimated)

$
1,144For the year ended December 31, 2003 (estimated)

$
698





4.    Derivatives and Financial Instruments





The Company addresses certain financial exposures through a program of risk management that includes the use of derivative financial instruments. To
date the Company has only entered into foreign currency forward exchange contracts generally expiring within one year to reduce the effects of fluctuating foreign currency exchange rates on forecasted cash requirements.





All derivatives are recognized on the balance sheet at their fair value. The Company has designated its derivatives as foreign currency cash flow hedges. Changes
in the fair value of derivatives that are highly effective as, and that are designated and qualify as, foreign currency cash flow hedges are recorded in other comprehensive income until the associated hedged transaction impacts earnings.





The Company formally documents all relationships between hedging instruments and hedged items, as well as its risk-management objective
and strategy for undertaking various hedge transactions. The Company also formally assesses, both at the hedges inception and on an ongoing basis, whether the derivatives that are used in hedging transactions are highly effective in offsetting
changes in fair values or cash flows of hedged items. When it is determined that a derivative is not highly effective as a hedge or that it has ceased to be a highly effective hedge, the Company discontinues hedge accounting prospectively.





The purpose of the hedging activities is to minimize the effect of foreign exchange rate movements on the cash flows related to the
Companys funding of Maxygen ApS. All foreign currency contracts are denominated in Danish kroner. At June 30, 2002, the Company had foreign currency contracts outstanding in the form of forward exchange contracts totaling $6.3 million.





5.    Collaborative Agreements





Cargill Dow LLC





In March 2002, Codexis, Inc., a wholly-owned subsidiary of the
Company, established a collaboration with Cargill Dow LLC, to research and develop a novel process for the production of lactic acid. The goal of the collaboration is to further improve Cargill Dows novel low-cost process for the production of
lactic acid from natural sugars derived from annually renewable resources, such as corn. Under the terms of the collaboration, Codexis will receive technology access payments and full research funding, and may receive research and commercialization
milestones. Codexis will also receive royalties on any sales of products manufactured using its technologies. Cargill Dow has worldwide commercialization rights for products generated from any improved production process developed in the
collaboration.




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##### Table of Contents




Delta and Pine Land Company





In May 2002, MaxyAg, Inc., a wholly-owned subsidiary of the Company, whose results are reported under the Agriculture segment (as described in Note 7), established a joint venture with
Delta and Pine Land Company (D&PL) to develop and commercialize for the cotton seed market gene leads developed using MaxyAgs technologies. The joint venture, called DeltaMax Cotton LLC (DeltaMax), will focus on the
creation of gene-based improvements for herbicide tolerance and pest and disease control in cotton. Under the terms of the joint venture agreement, DeltaMax will contract research and development activities to MaxyAg, D&PL and third parties, and
license products to D&PL and, potentially, other cotton seed companies, for commercialization. DeltaMax is 50/50 jointly owned by MaxyAg and D&PL and such parties will share income earned by the joint venture.





The Companys share of the joint ventures loss totaled approximately $229,000, and is recorded, under the equity method of accounting, as a single
line item in the Condensed Consolidated Statement of Operations. The Company received a payment of $1.7 million relating to past research and recognized $300,000 of this payment as collaborative research and development revenue in the three and six
months ended June 30, 2002. The remaining amount will be recognized ratably over the term of the related research plans. MaxyAg and D&PL are committed to fund the joint venture in an amount sufficient to pay the anticipated development costs,
but neither party shall be required to provide funding in excess of $15 million. During May 2002, the Company funded the joint venture in the amount of $1 million as an initial capital contribution, which reflects its 50% ownership interest.





6.    Litigation





In December 2001, a lawsuit was filed in the U.S. District Court for the Southern District of New York against Maxygen, Inc., certain officers of the Company, and certain underwriters of the Companys initial public
offering and secondary public offering of common stock. The lawsuit, which alleges claims under Sections 11, 12(a)(2) and 15 of the Securities Act of 1933 and Section 10(b) of the Securities Exchange Act of 1934, is among the so-called
laddering cases that have been commenced against a number of companies that had public offerings of securities prior to December 2000. The complaint has been consolidated with other laddering claims in a proceeding styled In re
Initial Public Offering Securities Litigation, No. 21 MC 92 (SAS), pending before the Honorable Shira A. Scheindlin. In early 2002 the Company was served with the complaint, and in April 2002 the Company was served with an amended complaint.





The complaint seeks damages in an unspecified amount. The Company believes that the claims alleged against the Company and its officers
are without merit and intends to defend the action vigorously. The Company does not expect the outcome of this matter to have a material effect on its financial position or results from operations.





The Company is aware of litigation involving a Company service provider under which the service provider may, under certain circumstances, be entitled to
reimbursement from the Company for its litigation and settlement costs. The damages sought in the litigation are unspecified. Even if reimbursement is payable, the Company does not believe that such payments will have a material adverse impact on
its financial position or results of operations.




11




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##### Table of Contents




7.    Segment Information





The Company has four reportable segments: human therapeutics, agriculture, chemicals and all other. The Company has determined its reportable operating segments
based upon how the business is managed and operated. The accounting policies of the segments described above are the same as those described in Note 1 in this report and in the Companys annual report on Form 10-K. The Company does not identify
or allocate assets by operating segment, nor does management evaluate segments on these criteria.





Segment Earnings





The Company evaluates the performance of its operating segments without considering the effects of net interest expense and income, amortization of
intangibles or stock compensation expense, all which are managed by corporate headquarters. Corporate administrative costs including depreciation and amortization expense are allocated based on headcount.





The following table presents segment operating loss reconciled to reported net loss:





(in thousands)

Three Months ended June
30,


Six Months ended June
30,2001


2002


2001


2002Human therapeutics

$
(5,417
)

$
(4,383
)

$
(11,365
)

$
(8,440
)Chemicals


(2,012
)


(1,762
)


(4,097
)


(4,221
)Agriculture


(1,504
)


(862
)


(2,688
)


(1,633
)All other


(374
)


(1,274
)


(471
)


(2,682
)Total segment loss

$
(9,307
)

$
(8,281
)

$
(18,621
)

$
(16,976
)Interest income, net


3,455



1,807



7,429



3,972Stock compensation


(3,512
)


(1,951
)


(7,055
)


(4,128
)Amortization of intangibles


(2,182
)


(286
)


(4,363
)


(572
)Total net loss

$
(11,546
)

$
(8,711
)

$
(22,610
)

$
(17,704
)





Segment Revenue





Revenues for each operating segment are derived from the Companys research collaboration agreements and government grants and are categorized based on the industry of the product or technology
under development.





(in thousands)

Three Months ended June 30,

Six Months ended June
30,2001

2002

2001

2002Human therapeutics

$
3,167

$
5,094

$
6,030

$
10,023Chemicals


1,893


2,260


3,304


3,924Agriculture


2,616


3,160


5,272


5,907Total revenue

$
7,676

$
10,514

$
14,606

$
19,854





8.    Subsequent Event





In July 2002, the Company was awarded a $2.4 million, three-year grant from the U.S. Army Medical Research and Material Command to develop cross protective
vaccines against three viruses that cause encephalitis.




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Forward Looking Statements





This report contains forward-looking statements within the meaning of federal securities laws that relate to future events or our future financial performance. In some cases, you can
identify forward-looking statements by terminology such as may, can, will, should, expect, plan, anticipate, believe, estimate,
predict, intend, potential or continue or the negative of these terms or other comparable terminology. Risks and uncertainties and the occurrence of other events could cause actual results to differ
materially from these predictions. Factors that could cause or contribute to such differences include those discussed below under Risk Factors That May Affect Results of Operations and Financial Condition, as well as those discussed in
our Annual Report on Form 10-K for the year ended December 31, 2001.





Although we believe that the expectations reflected in the
forward-looking statements are reasonable, we cannot guarantee future results, levels of activity, performance or achievements. Moreover, neither we nor any other person assumes responsibility for the accuracy and completeness of these statements.
We are under no duty to update any of the forward-looking statements after the date of this report or to conform these statements to actual results.





---




ITEM 2


MANAGEMENTS DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS





Overview





Maxygen was founded in May 1996
and began operations in March 1997. To date, we have generated revenues from research collaborations with agriculture, pharmaceutical, petroleum, and chemical companies and from government grants. We have strategic collaborations with leading
companies including: Aventis Pasteur in novel vaccines; Celltech in antibodies; InterMune in next generation interferon gamma therapies; Lundbeck in interferon beta therapies for central nervous system diseases and multiple sclerosis;
ALK-Abelló in allergy; the International AIDS Vaccine Initiative (IAVI) in HIV; Pfizer and DSM in pharmaceutical manufacturing; and Shearwater Corporation in protein pharmaceutical PEGylation technologies. Additionally, we have a range of
other strategic alliances in industrial applications, as well as funding from U.S. government organizations including from the Defense Advanced Research Projects Agency, the National Institute of Standards and Technology-Advanced Technology Program,
the U.S. Agency for International Development and the U.S. Army Medical Research and Material Command.





Revenue under strategic alliances
and government grants increased from $24.5 million in 2000, to $30.5 million in 2001 and was $19.9 million in the six months ended June 30, 2002. Revenues may fluctuate from period to period and there can be no assurance that these collaborations
will continue for their initial term or beyond.





We have incurred significant losses since our inception. As of June 30, 2002, our
accumulated deficit was $146.4 million and total stockholders equity was $242.9 million. We have invested heavily in establishing our proprietary technologies. These investments have contributed to the increases in operating expenses from
$70.4 million in 2000 (excluding $29.0 million of acquired in-process research and development expense) to $88.4 million in 2001, to $41.3 million in the six months ended June 30, 2002. Our total headcount increased from 252 employees at the end of
2000 to 305 employees at the end of 2001. As of June 30, 2002 we had 308 employees, of whom 84% were engaged in research and development. We expect to incur additional operating losses over at least the next several years as we continue to expand
our research and development efforts and infrastructure.




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##### Table of Contents




Source of Revenue and Revenue Recognition Policy





We recognize revenues from research collaboration agreements as earned upon achievement of the performance requirements of the agreements. Our existing corporate
collaboration agreements generally provide for research funding for a specified number of full time equivalent researchers working in defined research programs. Revenue related to these payments is earned as the related research work is performed.
In addition, these collaborators may make technology advancement payments that are intended to fund development of our core technology, as opposed to a defined research program. These payments are recognized ratably over the applicable funding
period. Payments received that are related to future performance are deferred and recognized as revenue as the performance requirements are achieved. As of June 30, 2002, we have deferred revenues of approximately $12.9 million.





Revenue related to performance milestones is recognized based upon the achievement of the milestones, as defined in the respective agreements.
Payments received related to substantive, at-risk incentive milestones, if any, are recognized as revenue upon achievement of the incentive milestone event because we have no future performance obligations related to the payment and we judge the
event to be the culmination of a separate earnings process. Incentive milestone payments are triggered either by the results of our research efforts or by events external to Maxygen, such as regulatory approval to market a product. Royalties are
recorded as earned in accordance with the contract terms when third party results are reliably measured and collectibility is reasonably assured.





Revenue related to grant agreements with various government agencies is recognized as the related research and development expenses are incurred, and when these research and development expenses are within the prior approved funding
amounts. Certain grant agreements provide an option for the government to audit the amount of research and development expenses, both direct and indirect, that have been submitted to the government agency for reimbursement. We believe the overhead
rates we used to calculate our indirect research and development expenses are within the contractual guidelines of allowable costs and are reasonable estimates of our indirect expenses incurred through the term of the agreement.





Our sources of potential revenue for the next several years are likely to be license, research, technology advancement and milestone payments under
existing and possible future collaborative arrangements, government research grants, and royalties from our collaborators based upon revenues received from any products commercialized under those agreements.





Deferred Compensation





Deferred
compensation for options granted to employees has been determined as the difference between the deemed fair market value for financial reporting purposes of our common stock on the date the applicable options were granted and the exercise price.
Deferred compensation for options granted to consultants has been determined in accordance with Statement of Financial Accounting Standards No. 123 and EITF 96-18 as the fair value of the equity instruments issued. Compensation for related options
granted to consultants is periodically remeasured as the underlying options vest.





In connection with the grant of stock options to
employees before our initial public offering, we recorded deferred stock compensation of approximately $2.4 million in 1998 and $19.5 million in 1999. These amounts were initially recorded as a component of stockholders equity and are being
amortized as charges to operations over the vesting period of the options using a graded vesting method. We recognized stock compensation expense related to the deferred compensation amortization on these option grants as follows:





(in thousands)

Three Months ended June 30,

Six Months ended June
30,2001

2002

2001

2002Research and development

$
615

$
408

$
1,262

$
837General and administrative


637


415


1,304


987Total deferred compensation amortization

$
1,252

$
823

$
2,566

$
1,824





Stock compensation expense in connection with the grant of stock options to consultants
for the three and six months ended June, 2001 and 2002 were insignificant.




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In connection with the Maxygen ApS acquisition in August 2000, stock options were granted in exchange
for outstanding warrants to purchase Maxygen ApS securities. In connection with this exchange we recorded aggregate deferred compensation totaling $1.5 million. This amount is being amortized over the remaining vesting period of the options, of
which $179,000 and $357,000 was expensed in the three and six months ended June 30, 2001 and $160,000 and $338,000 in the comparable periods for 2002. For the shares exchanged that had a right of repurchase, deferred compensation of $13.1 million
was recorded. This amount is being amortized to expense over a three-year graded vesting period. A total of $2.0 million and $4.0 million was recognized as expense for the three and six months ended June 30, 2001, and $920,000 and $1.8 million in
the comparable periods for 2002.





Results of Operations





Revenues





Our total revenues increased from $7.7
million and $14.6 million in the three and six months ended June 30, 2001, to $10.5 million and $19.9 million in the comparable periods of 2002. The increase in collaborative research and development revenue was due to additional strategic alliances
and the expansion of existing alliances. The decline in grant revenue reflects the expiration of three government grants that began in late 1998 and early 1999. We expect our total revenues to be relatively flat for the remainder of 2002.





Revenues for each operating segment are derived from our research collaboration agreements and government research grants and are
categorized based on the industry of the product or technology under development.





(in thousands)

Three Months ended June 30,

Six Months ended June
30,2001

2002

2001

2002Human therapeutics

$
3,167

$
5,094

$
6,030

$
10,023Chemicals


1,893


2,260


3,304


3,924Agriculture


2,616


3,160


5,272


5,907Total revenue

$
7,676

$
10,514

$
14,606

$
19,854





The increase in revenue for each segment was due to additional strategic alliances and the
expansion of existing alliances.





Research and Development Expenses





We have entered into a number of research and development collaborations to perform research for our collaborators. The major collaborative agreements all have
similar contractual terms. The agreements generally require us to devote a specified number of full-time equivalent employees to the research efforts over defined terms ranging from three to five years.




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We do not track fully burdened research and development costs or capital expenditures by project.
However, we estimate, based on full-time equivalent (FTE) effort, that research and development costs (measured in hours incurred) approximated as follows:





Three Months ended June 30,


Six Months ended June 30,2001


2002


2001


2002Collaborative projects funded by collaborators and government grants

53
%

51
%

52
%

50
%Internally funded projects

47
%

49
%

48
%

50
%





Due to the nature of our research and our dependence on our collaborative partners to
commercialize the results of the research, we cannot predict with any certainty whether any particular collaboration or research effort will ultimately result in a commercial product and therefore whether we will receive future milestone payments or
royalty payments under our various collaborations.





Most of our human therapeutic, agriculture and chemical product development programs
are at an early stage and may not result in any marketed products. Product candidates that may appear promising at early stages of development may not reach the market for a number of reasons. Human therapeutic product candidates may be found
ineffective or cause harmful side effects during clinical trials, may take longer to pass through clinical trials than had been anticipated, may fail to receive necessary regulatory approvals and may prove impracticable to manufacture in commercial
quantities at reasonable costs and with acceptable quality. Chemical and agricultural product candidates may be found ineffective, may cause undesirable side effects or may prove impracticable to manufacture in commercial quantities at reasonable
costs and with acceptable quality. Furthermore, it is uncertain which of our internally developed product candidates will be subject to future collaborative arrangements. The participation of a collaborative partner may accelerate the time to
completion and reduce the cost to us of a product candidate or it may delay the time and increase the cost to us due to the alteration of our existing strategy. The risks and uncertainties associated with our research and development projects are
discussed more fully in the section of this report titled Risk Factors That May Affect Results of Operations and Financial Condition. Because of these risks and uncertainties, we cannot predict when or whether we will successfully
complete the development of our product candidates or the ultimate product development cost in any particular case.





Our research and
development expenses consist primarily of salaries and other personnel-related expenses, facility costs, research consultants and external collaborative research expenses, supplies and depreciation of facilities and laboratory equipment. Research
and development expenses increased from $13.0 million and $25.7 million for the three and six months ended June 30, 2001 to $15.4 million and $30.4 million in the comparable periods of 2002. In addition, stock compensation expense related to
research and development was $2.9 million and $5.8 million for the three and six months ended June 30, 2001 and $1.5 million and $3.1 million in the comparable periods of 2002. The increase in total research and development expense is primarily due
to our accelerated efforts in all aspects of research and development as well as investments in our technology platforms and in the development of product candidates. The decrease in stock compensation expense is primarily a result of lower
amortization expense related to deferred compensation for the shares exchanged that had a right of repurchase in connection with the Maxygen ApS acquisition in August 2000. This amount is being amortized to expense over a three year graded vesting
period.





Research and development expenses, excluding stock compensation expense, represented 170% and 176% of total revenues for the
three and six months ended June 30, 2001 and 146% and 153% in the comparable periods of 2002. The decreases were primarily due to growth in our total revenue between periods.





We expect research and development cost to increase during the remainder of 2002 as efforts on internally funded projects increase, new projects are initiated under existing collaboration agreements
and as new collaboration arrangements are consummated. We expect to continue to devote substantial resources to research and development, and we expect that research and development expenses will continue to increase in absolute dollars for at least
the next several years.




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General and Administrative Expenses





Our general and administrative expenses consist primarily of personnel costs for finance, human resources, business development, legal and general management, as
well as professional expenses, such as legal and accounting and insurance premiums. General and administrative expenses decreased from $4.0 million and $7.5 million for the three and six months ended June 30, 2001 to $3.2 million and $6.2 million in
the comparable periods of 2002. In addition, general and administrative stock compensation expense was $637,000 and $1.3 million for the three and six months ended June 30, 2001 and $440,000 and $1.0 million in the comparable periods of 2002. The
decrease in total general and administrative expenses is primarily due to reimbursement of legal expenses of $657,000 received in the first quarter of 2002 resulting from the arbitration proceeding against Enchira Biotechnology Corporation. The
decrease is also due to lower spending on legal expenses and investor relation programs in 2002.





General and administrative expenses,
excluding stock compensation expense, represented 51% of total revenues for both the three and six months ended June 30, 2001 and 30% and 31% in the comparable periods of 2002. The decreases were due to the growth in our total revenue between
periods combined with the decrease in general and administrative expenses.





We expect that our general and administrative expenses will
increase in absolute dollar amounts for at least the next several years as we expand our staff and add infrastructure and as a result of increased professional fees and insurance premiums. We expect that research and development activities will
expand more quickly than our general and administrative expenses over the next several years. As a percentage of revenue, general and administrative expenses will fluctuate depending upon the levels of revenue.





Goodwill and Other Intangible Assets





In connection with the Maxygen ApS acquisition, we allocated $26.2 million to goodwill and other intangible assets and were initially amortizing this goodwill and other intangible assets using the straight-line method over
the assets estimated useful lives of three years, the term of expected benefit. We believed this term was reasonable given that Maxygen ApS was a development stage entity and its technology was at an early stage of development and was yet unproven.
Amortization expense for goodwill and other intangible assets of $2.2 million and $4.4 million for the three and six months ended June 30, 2001 and amortization expense of other intangible assets of $286,000 and $572,000 in the comparable periods of
2002 was recorded.





In June 2001, the Financing Accounting Standard Board issued Statement of Financial Accounting Standards No. 141,
Business Combinations and No. 142, Goodwill and Other Intangible Assets, effective for the fiscal years beginning after December 15, 2001. Under the new rules, goodwill will no longer be amortized but will be subject to annual impairment tests in
accordance with Statement No. 142. Other intangible assets will continue to be amortized over the useful lives. We adopted the provisions of SFAS 141 and SFAS 142 effective January 1, 2002 and determined there was no impairment of goodwill. We are
required to perform goodwill impairment testing on an annual basis, and on an interim basis if and when indicators of impairment exist. There can be no assurance that future goodwill impairment tests will not result in a charge in earnings. See also
Note 3 of the Notes to Condensed Consolidated Financial Statements.





Net Interest Income





Net interest income represents income earned on our cash, cash equivalents and marketable securities net of interest expense. Net interest income
decreased from $3.5 million and $7.4 million for the three and six months ended June 30, 2001 to $1.8 million and $4.0 million in the comparable periods of 2002. This decrease was due to lower interest rates and lower average balances of cash, cash
equivalents and marketable securities.





Equity in Net Loss of Joint Venture





Equity in net loss of joint venture reflects Maxygens share of the net loss of its joint venture, DeltaMax Cotton LLC, formed in May 2002, which is
accounted for under the equity method of accounting. Equity in net losses of the joint venture was $229,000 for the three and six months ended June 30, 2002.




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Recent Accounting Pronouncements





In January 2002, we adopted Statement of Financing Accounting Standards No. 144 Accounting for the Impairment or Disposal of Long-Lived Assets (Statement 144),
which addresses financial accounting and reporting for the impairment or disposal of long-lived assets. We evaluate our intangible assets for impairment whenever events or changes in circumstances indicate that such assets are impaired or the
estimated useful lives are no longer appropriate. If indicators of impairment exist, we will review our long-lived assets for impairment based on estimated future discounted cash flows attributable to the assets and other factors to determine the
fair value of the respective assets. In the event such cash flows are not expected to be sufficient to recover the recorded value of the assets, the assets are written down to their estimated fair values.





Liquidity and Capital Resources





Since
inception, we have financed our operations primarily through private placements and public offerings of equity securities, receiving aggregate consideration from such sales of such equity securities totaling $302.5 million and research and
development funding from collaborators and government grants totaling approximately $145.4 million. As of June 30, 2002, we had $221.5 million in cash, cash equivalents and investments.





Our operating activities used cash of $4.0 million for the six months ended June, 2001 and $10.8 million for the six months ended June 30, 2002. Uses of cash in operating activities were
primarily to fund net operating losses.





Our investing activities used cash of $37.1 million for the six months ended June, 2001 and
provided cash of $69.7 million for the six months ended June 30, 2002. The cash used during the six months ended June 30, 2001 primarily represented the purchases of available-for-sale securities. The cash provided during the six months ended June
30, 2002 primarily represented the maturities of available-for-sale securities.





Additions of property and equipment were $3.3 million
for the six months ended June 30, 2001 and $2.1 million for the six months ended June 30, 2002 which includes a $479,000 adjustment from foreign currency translation at June 30, 2002 resulting from our cumulative purchases of equipment for our
Danish operations. We expect to continue to make significant investments in the purchase of property and equipment to support our expanding operations. We may use a portion of our cash to acquire or invest in complementary businesses, products or
technologies, or to obtain the right to use such complementary technologies.





In connection with our joint venture, DeltaMax Cotton LLC,
Maxygen and D&PL are committed to fund the joint venture in an amount sufficient to pay the anticipated development costs, but neither party is required to provide funding in excess of $15 million. During May 2002, we funded the joint venture in
the amount of $1 million as an initial capital contribution, which reflects our 50% ownership interest.





The following are contractual
commitments at June 30, 2002 associated with debt and lease obligations (in thousands):





Payments Due by PeriodContractual Commitment

Total

1 year

2-3 yearsOperating Leases

$
12,578

$
4,887

$
7,691Long-Term Debt


993


660


333Total Contractual Commitments

$
13,571

$
5,547

$
8,024





Financing activities provided cash of $136,000 for the six months ended June 30, 2001 and
$1.7 million for the six months ended June 30, 2002. The cash provided in the six months ended June 30, 2001 and 2002 was primarily from the proceeds of the sale of common stock in connection with our Employee Stock Purchase Plan and the exercise of
stock options by




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employees. The change is also due to a noncash 401(k) matching contribution from the Company. In
addition, at June 30, 2002, there was an equity adjustment of $756,000 resulting from foreign currency translation of our Danish subsidiarys financial statements. This was partially offset by payments on equipment financing obligations.





Assuming our research efforts for existing collaborations are expended for the full research term, as of June 30, 2002 we have total
committed funding of $145.4 million, of which approximately $112.5 million is from our collaborators and $32.9 million is from government funding. Of these committed funds, we have $47.3 million remaining to be received over the next four years. In
addition, potential milestone payments from our existing collaborations could exceed $309 million based on the accomplishment of specific performance criteria, and we may earn royalties on product sales. In general, the obligation of our corporate
collaborators to provide research funding cannot be terminated by either party before the end of the research term unless there has been a material breach of contract or either party has become bankrupt or insolvent. In the case of such an event,
the agreement specifies the rights, if any, that each party will retain.





We believe that our current cash, cash equivalents, short-term
investments and long-term investments together with funding received from collaborators and government grants will be sufficient to satisfy our anticipated cash needs for working capital and capital expenditures for at least the next 12 months.
However, it is possible that we will seek additional financing within this timeframe. We may raise additional funds through public or private financing, collaborative relationships or other arrangements. Additional funding, if sought, may not be
available on terms favorable to us. Further, any additional equity financing may be dilutive to stockholders, and debt financing, if available, may involve restrictive covenants. Our failure to raise capital when needed may harm our business and
operating results.





RISK FACTORS THAT MAY AFFECT RESULTS OF OPERATIONS AND FINANCIAL CONDITION





You should carefully consider the risks described below, together with all of the other information included in this report, in considering our
business and prospects. The risks and uncertainties described below are not the only ones facing Maxygen. Additional risks and uncertainties not presently known to us or that we currently deem immaterial also may impair our business operations. If
any of the following risks actually occur, our business could be harmed. In such case, the trading price of our common stock could decline, and you may lose all or part of your investment.





We Have a History of Net Losses. We Expect to Continue to Incur Net Losses and We May Not Achieve or Maintain Profitability.





We have incurred net losses since our inception, including a net loss of approximately $59.6 million in 2000, $45.0 million in 2001 and $17.7 million in the six months ended June 30, 2002.
As of June 30, 2002, we had an accumulated deficit of approximately $146.4 million. We expect to have increasing net losses and negative cash flow for at least the next several years. The size of these net losses will depend, in part, on the rate of
growth, if any, in our contract revenues and on the level of our expenses. To date, we have derived all our revenues from collaborations and grants and expect to derive a majority of our revenue from such sources for at least the next several years.
Revenues from collaborations and grants are uncertain because our existing agreements have fixed terms and because our ability to secure future agreements will depend upon our ability to address the needs of our potential future collaborators. We
expect to spend significant amounts to fund research and development and enhance our core technologies. We expect costs to increase further due to expanded operations and costs associated with operating in multiple international locations. As a
result, we expect that our operating expenses will increase in the near term and, consequently, we will need to generate significant additional revenues to achieve profitability. Even if we do achieve profitability, we may not be able to sustain or
increase profitability on a quarterly or annual basis.





Commercialization of Our Technologies Depends On Collaborations With Other
Companies. If We Are Unable to Find Collaborators in the Future, We May Not Be Able to Develop Our Technologies or Products.





Since
we do not currently possess the resources necessary to develop and commercialize potential products that may result from our technologies, or the resources to complete any approval processes that may be required for these products, we must enter
into collaborative arrangements to develop and




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commercialize products. We have entered into collaborative agreements with other companies to fund the development of certain new products for
specific purposes. These contracts expire after a fixed period of time. If they are not renewed or if we do not enter into new collaborative agreements, our revenues will be reduced and our products may not be commercialized.





We have limited or no control over the resources that any collaborator may devote to our products. Any of our present or future collaborators may not
perform their obligations as expected. These collaborators may breach or terminate their agreement with us or otherwise fail to conduct their collaborative activities successfully and in a timely manner. Further, our collaborators may elect not to
develop products arising out of our collaborative arrangements or devote sufficient resources to the development, manufacture, marketing or sale of these products. If any of these events occur, we may not be able to develop our technologies or
commercialize our products.





We Are an Early Stage Company Deploying Unproven Technologies. If We Do Not Develop Commercially
Successful Products, We May Be Forced to Cease Operations.





You must evaluate us in light of the uncertainties and complexities
affecting an early stage biotechnology company. Our proprietary technologies are new and in the early stage of development. We may not develop products that prove to be safe and efficacious, meet applicable regulatory standards, are capable of being
manufactured at reasonable costs or can be marketed successfully.





We may not be successful in the commercial development of products.
Successful products will require significant development and investment, including testing, to demonstrate their cost-effectiveness before their commercialization. To date, companies in the biotechnology industry have developed and commercialized
only a limited number of products. We have not proven our ability to develop and commercialize products. We must conduct a substantial amount of additional research and development before any regulatory authority will approve any of our products.
Our research and development may not indicate that our products are safe and effective, in which case regulatory authorities may not approve them. Problems frequently encountered in connection with the development and utilization of new and unproven
technologies and the competitive environment in which we operate might limit our ability to develop commercially successful products.





We Intend to Conduct Proprietary Research Programs, and Any Conflicts With Our Collaborators or Any Inability to Commercialize Products Resulting from This Research Could Harm Our Business.





An important part of our strategy involves conducting proprietary research programs. We may pursue opportunities in fields that could conflict with those of our
collaborators. Moreover, disagreements with our collaborators could develop over rights to our intellectual property. Any conflict with our collaborators could reduce our ability to obtain future collaboration agreements and negatively impact our
relationship with existing collaborators, which could reduce our revenues.





Certain of our collaborators could become our competitors in
the future. Our collaborators could develop competing products, preclude us from entering into collaborations with their competitors, fail to obtain timely regulatory approvals, terminate their agreements with us prematurely or fail to devote
sufficient resources to the development and commercialization of products. Any of these developments could harm our product development efforts.





We will either commercialize products resulting from our proprietary programs directly or through licensing to other companies. We have no experience in manufacturing and marketing, and we currently do not have the resources or
capability to manufacture products on a commercial scale. In order for us to commercialize these products directly, we would need to develop, or obtain through outsourcing arrangements, the capability to manufacture, market and sell products. We do
not have these capabilities, and we may not be able to develop or otherwise obtain the requisite manufacturing, marketing and sales capabilities. If we are unable to successfully commercialize products resulting from our proprietary research
efforts, we will continue to incur losses.




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We May Encounter Difficulties in Managing Our Growth. These Difficulties Could Increase Our Losses.





We have experienced rapid and substantial growth that has placed and, if this growth continues as expected, will continue to place a
strain on our human and capital resources. If this growth continues, our losses will likely increase. The number of our employees increased from 252 at December 31, 2000 to 305 at December 31, 2001 and 308 at June 30, 2002. Our revenues increased
from $24.5 million in 2000 to $30.5 million in 2001 and were $19.9 million in the six months ended June 30, 2002. Our ability to manage our operations and growth effectively requires us to continue to expend funds to enhance our operational,
financial and management controls, reporting systems and procedures and to attract and retain sufficient numbers of talented employees. If we are unable to implement improvements to our management information and control systems in an efficient or
timely manner, or if we encounter deficiencies in existing systems and controls, then management may have access to inadequate information to manage our day-to-day operations. Failure to attract and retain sufficient numbers of talented employees
will further strain our human resources and could impede our growth and ability to satisfy our obligations under collaboration agreements. This would reduce our revenue, increase our losses and harm our reputation in the marketplace.





The Operation of International Locations May Increase Operating Expenses and Divert Management Attention.





We are expanding internationally. In August 2000 we acquired Maxygen ApS, a Danish biotechnology company, and are now operating with international business
locations. Expansion into an international operational entity will require additional management attention and resources. We have limited experience in localizing our operations and in conforming our operations to local cultures, standards and
policies. We may have to compete with local companies who understand the local situation better than we do. We may not be successful in expanding into international locations or in generating revenues from foreign operations. Even if we are
successful, the costs of operating internationally are expected to exceed our international revenues for at least the next several years. As we continue to expand internationally, we are subject to risks of doing business internationally, including
the following:





| |  |  | regulatory requirements that may limit or prevent the offering of our products in local jurisdictions;
| | - |  | ------------------------------------------------------------------------------------------------------




| |  |  | government limitations on research and/or research involving genetically engineered products or processes;
| | - |  | ----------------------------------------------------------------------------------------------------------




| |  |  | difficulties in staffing and managing foreign operations;
| | - |  | ---------------------------------------------------------




| |  |  | longer payment cycles, different accounting practices and problems in collecting accounts receivable;
| | - |  | -----------------------------------------------------------------------------------------------------




| |  |  | cultural non-acceptance of genetic manipulation and genetic engineering; and
| | - |  | ----------------------------------------------------------------------------




| |  |  | potentially adverse tax consequences.
| | - |  | -------------------------------------




To the extent we expand our international operations and have additional portions of our international revenues denominated in foreign currencies, we also could become subject to increased difficulties in collecting accounts
receivable and risks relating to foreign currency exchange rate fluctuations.





Acquisitions Could Result in Dilution, Operating
Difficulties and Other Harmful Consequences.





If appropriate opportunities present themselves, we intend to acquire businesses and
technologies that complement our capabilities. The process of integrating any acquisition may create unforeseen operating difficulties and expenditures and is itself risky. The areas where we may face difficulties include:





| |  |  | diversion of management time (both ours and that of the acquired company) from focus on operating the businesses to issues of integration during the period of
negotiation through closing and further diversion of such time after closing;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------




| |  |  | decline in employee morale and retention issues resulting from changes in compensation, reporting relationships, future prospects, or the direction of the
business;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------




| |  |  | the need to integrate each companys accounting, management information, human resource and other administrative systems to permit effective management and
the lack of control if such integration is delayed or not implemented; and
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------




| |  |  | the need to implement controls, procedures and policies appropriate for a larger public company in companies that before acquisition had been smaller, private
companies.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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We do not have extensive experience in managing this integration process. Moreover, the anticipated
benefits of any or all of these acquisitions may not be realized.





Future acquisitions could result in potentially dilutive issuances of
equity securities, the incurrence of debt, contingent liabilities or amortization expenses related to goodwill and other intangible assets, any of which could harm our business. Future acquisitions may require us to obtain additional equity or debt
financing, which may not be available on favorable terms or at all. Even if available, this financing may be dilutive.





Since Our
Technologies Can Be Applied to Many Different Industries, If We Focus Our Efforts on Industries That Fail to Produce Viable Product Candidates, We May Fail to Capitalize on More Profitable Areas.





We have limited financial and managerial resources. Since our technologies may be applicable to numerous, diverse industries, we must prioritize our application
of resources to discrete efforts. This requires us to focus on product candidates in selected industries and forego efforts with regard to other products and industries. Our decisions may not produce viable commercial products and may divert our
resources from more profitable market opportunities.





Public Perception of Ethical and Social Issues May Limit the Use of Our
Technologies, Which Could Reduce Our Revenues.





Our success will depend in part upon our ability to develop products discovered
through our technologies. Governmental authorities could, for social or other purposes, limit the use of genetic processes or prohibit the practice of our directed molecular evolution technologies or other technologies. Ethical and other concerns
about our directed molecular evolution technologies or other technologies, particularly the use of genes from nature for commercial purposes, and products resulting therefrom, could adversely affect their market acceptance.





If the Public Rejects Genetically Engineered Products, We Will Have Less Demand for Our Products.





The commercial success of our potential products will depend in part on public acceptance of the use of genetically engineered products including drugs, plants and plant products. Claims
that genetically engineered products are unsafe for consumption or pose a danger to the environment may influence public attitudes. Our genetically engineered products may not gain public acceptance. Negative public reaction to genetically modified
organisms and products could result in greater government regulation of genetic research and resultant products, including stricter labeling laws or regulations, and could cause a decrease in the demand for our products.





The subject of genetically modified organisms has received negative publicity in Europe and the United States, which has aroused public debate. The adverse
publicity could lead to greater regulation and trade restrictions on genetic research and the resultant agricultural and other products could be subject to greater domestic or international regulation. Such regulation and restrictions could cause a
decrease in the demand for our products.





Many Potential Competitors Who Have Greater Resources and Experience Than We Do May Develop
Products and Technologies That Make Ours Obsolete.





The biotechnology industry is characterized by rapid technological change, and
the area of gene research is a rapidly evolving field. Our future success will depend on our ability to maintain a competitive position with respect to technological advances. Rapid technological development by others may result in our products and
technologies becoming obsolete.





We face, and will continue to face, intense competition from organizations such as large and small
biotechnology companies, as well as academic and research institutions and government agencies that are pursuing competing technologies for modifying DNA and proteins. These organizations may develop




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technologies that are alternatives to our technologies. Further, our competitors in the directed molecular evolution field may be more effective
at implementing their technologies to develop commercial products. Some of these competitors have entered into collaborations with leading companies within our target markets to produce commercial products.





Any products that we develop through our technologies will compete in multiple, highly competitive markets. Most of the organizations competing with us in the
markets for such products have greater capital resources, research and development and marketing staffs and facilities and capabilities, and greater experience in modifying DNA and proteins, obtaining regulatory approvals, manufacturing products and
marketing.





Accordingly, our competitors may be able to develop technologies and products more easily, which would render our
technologies and products and those of our collaborators obsolete and noncompetitive.





Any Inability to Adequately Protect Our
Proprietary Technologies Could Harm Our Competitive Position.





Our success will depend in part on our ability to obtain patents and
maintain adequate protection of our intellectual property for our technologies and products in the U.S. and other countries. If we do not adequately protect our intellectual property, competitors may be able to practice our technologies and erode
our competitive advantage. The laws of some foreign countries do not protect proprietary rights to the same extent as the laws of the U.S., and many companies have encountered significant problems in protecting their proprietary rights in these
foreign countries. These problems can be caused by, for example, a lack of rules and processes allowing for meaningfully defending intellectual property rights.





The patent positions of biopharmaceutical and biotechnology companies, including our patent positions, are often uncertain and involve complex legal and factual questions. We will be able to protect our proprietary rights
from unauthorized use by third parties only to the extent that our proprietary technologies are covered by valid and enforceable patents or are effectively maintained as trade secrets. We apply for patents covering our technologies and products as
we deem appropriate. However, we may not obtain patents on all inventions for which we seek patents, and any patents we obtain may be challenged and may be narrowed in scope or extinguished as a result of such challenges. Our existing patents and
any future patents we obtain may not be sufficiently broad to prevent others from practicing our technologies or from developing competing products. Others may independently develop similar or alternative technologies or design around our patented
technologies or products. In addition, others may challenge or invalidate our patents, or our patents may fail to provide us with any competitive advantages.





We rely upon trade secret protection for our confidential and proprietary information. We have taken security measures to protect our proprietary information. These measures may not provide adequate protection for our trade
secrets or other proprietary information. We seek to protect our proprietary information by entering into confidentiality agreements with employees, collaborators and consultants. Nevertheless, employees, collaborators or consultants may still
disclose or misuse our proprietary information, and we may not be able to meaningfully protect our trade secrets. In addition, others may independently develop substantially equivalent proprietary information or techniques or otherwise gain access
to our trade secrets.





Litigation or Other Proceedings or Third Party Claims of Intellectual Property Infringement Could Require Us to
Spend Time and Money and Could Shut Down Some of Our Operations.





Our commercial success depends in part on neither infringing
patents nor proprietary rights of third parties, nor breaching any licenses that we have entered into with regard to our technologies and products. Others have filed, and in the future are likely to file, patent applications covering genes or gene
fragments that we may wish to utilize with our proprietary technologies, or products that are similar to products developed with the use of our technologies or alternative methods of generating gene diversity. If these patent applications result in
issued patents and we wish to use the claimed technology, we would need to obtain a license from the third party.





Third parties may
assert that we are employing their proprietary technology without authorization. In addition, third parties may obtain patents in the future and claim that use of our technologies infringes these patents. We could incur substantial costs and
diversion of the time and attention of management




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and technical personnel in defending ourselves against any of these claims or enforcing our patents or other intellectual property rights
against others. Furthermore, parties making claims against us may be able to obtain injunctive or other equitable relief that could effectively block our ability to further develop, commercialize and sell products, and such claims could result in
the award of substantial damages against us. In the event of a successful claim of infringement against us, we may be required to pay damages and obtain one or more licenses from third parties. We may not be able to obtain these licenses at a
reasonable cost, if at all. In that event, we could encounter delays in product introductions while we attempt to develop alternative methods or products or be required to cease commercializing affected products.





We routinely monitor the public disclosures of other companies operating in our industry regarding their technological development efforts. If we determine that
these efforts violate our intellectual property or other rights, we intend to take appropriate action, which could include litigation. Any action we take could result in substantial costs and diversion of management and technical personnel.
Furthermore, the outcome of any action we take to protect our rights may not be resolved in our favor.





From time to time, Maxygen
becomes involved in claims and legal proceedings that arise in the ordinary course of its business. We are currently subject to one such claim. We do not believe that the resolution of this claim will have a material adverse effect on us.





If We Lose Key Personnel or Are Unable to Attract and Retain Additional Personnel We May Be Unable to Pursue Collaborations or
Develop Our Own Products.





We are highly dependent on the principal members of our management and scientific staff, the loss of whose
services might adversely impact the achievement of our objectives. In addition, recruiting and retaining qualified scientific personnel to perform future research and development work will be critical to our success. We do not currently have
sufficient executive management personnel to execute fully our business plan. There is currently a shortage of skilled executives, which is likely to continue. As a result, competition for skilled personnel is intense, and the turnover rate can be
high. Although we believe we will be successful in attracting and retaining qualified personnel, competition for experienced scientists from numerous companies and academic and other research institutions may limit our ability to do so on acceptable
terms. Failure to attract and retain personnel could prevent us from pursuing collaborations or developing our products or core technologies.





Our planned activities will require additional expertise in specific industries and areas applicable to the products developed through our technologies. These activities will require the addition of new personnel, including
management, and the development of additional expertise by existing management personnel. The inability to acquire these services or to develop this expertise could impair the growth, if any, of our business.





We Will Need Additional Capital in the Future. If Additional Capital is Not Available, We Will Have to Curtail or Cease Operations.





Our future capital requirements will be substantial and will depend on many factors including payments received under collaborative agreements and
government grants, the progress and scope of our collaborative and independent research and development projects, the effect of any acquisitions, and the filing, prosecution and enforcement of patent claims.





Changes may also occur that would consume available capital resources significantly sooner than we expect. We may be unable to raise sufficient additional
capital. If we fail to raise sufficient funds, we will have to curtail or cease operations. We anticipate that existing cash and cash equivalents and income earned thereon, together with anticipated cash flows from operations, will enable us to
maintain our currently planned operations for at least the next 12 months. If our capital resources are insufficient to meet future capital requirements, we will have to raise additional funds to continue the development of our technologies and
complete the commercialization of products, if any, resulting from our technologies.




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Some of Our Programs Depend on Government Grants, Which May Be Withdrawn. The Government Has License
Rights to Technology Developed With Its Funds.





We have received and expect to continue to receive funds under various U.S.
government research and technology development programs. The government may reduce funding in the future for a number of reasons. For example, some programs are subject to a yearly appropriations process in Congress. Additionally, we may not receive
funds under existing or future grants because of budgeting constraints of the agency administering the program. There can be no assurance that we will receive the entire funding under our existing or future grants.





Our grants provide the U.S. government a non-exclusive, non-transferable, paid-up license to practice for or on behalf of the inventions made with federal funds.
If the government exercises these rights, the U.S. government could use these inventions and our potential market could be reduced.





Our Potential Therapeutic Products Are Subject to a Lengthy and Uncertain Regulatory Process. If Our Potential Products Are Not Approved, We Will Not Be Able to Commercialize Those Products.





The Food and Drug Administration must approve any vaccine or therapeutic product before it can be marketed in the U.S. Before we can file a new drug application
or biologic license application with the FDA, the product candidate must undergo extensive testing, including animal and human clinical trials, which can take many years and require substantial expenditures. Data obtained from such testing are
susceptible to varying interpretations that could delay, limit or prevent regulatory approval. In addition, changes in regulatory policy for product approval during the period of product development and regulatory agency review of each submitted new
application or product license application may cause delays or rejections. The regulatory process is expensive and time consuming. The regulatory agencies of foreign governments must also approve our therapeutic products before the products can be
sold in those other countries.





Because our products involve the application of new technologies and may be based upon new therapeutic
approaches they may be subject to substantial review by government regulatory authorities and government regulatory authorities may grant regulatory approvals more slowly for our products than for products using more conventional technologies. We
have not submitted an application to the FDA or any other regulatory authority for any product candidate, and neither the FDA nor any other regulatory authority has approved any therapeutic product candidate developed with our MolecularBreeding
directed molecular evolution technologies for commercialization in the U.S. or elsewhere. We may not be able to, or our collaborators may not be able to, conduct clinical testing or obtain the necessary approvals from the FDA or other regulatory
authorities for our products.





Even after investing significant time and expenditures we may not obtain regulatory approval for our
products. Even if we receive regulatory approval, this approval may entail limitations on the indicated uses for which we can market a product. Further, once regulatory approval is obtained, a marketed product and its manufacturer are subject to
continual review, and discovery of previously unknown problems with a product or manufacturer may result in restrictions on the product, manufacturer or manufacturing facility, including withdrawal of the product from the market. In certain
countries, regulatory agencies also set or approve prices.





Laws May Limit Our Provision of Genetically Engineered Agricultural
Products in the Future. These Laws Could Reduce Our Ability to Sell These Products.





We may develop genetically engineered
agricultural products. The field-testing, production and marketing of genetically engineered plants and plant products are subject to federal, state, local and foreign governmental regulation. Regulatory agencies administering existing or future
regulations or legislation may not allow us to produce and market our genetically engineered products in a timely manner or under technically or commercially feasible conditions. In addition, regulatory action or private litigation could result in
expenses, delays or other impediments to our product development programs or the commercialization of resulting products.





The FDA
currently applies the same regulatory standards to foods developed through genetic engineering as apply to foods developed through traditional plant breeding. However, genetically engineered food products will be subject to pre-market review if
these products raise safety questions or are deemed to be




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food additives. Our products may be subject to lengthy FDA reviews and unfavorable FDA determinations if they raise questions, are deemed to be
food additives, or if the FDA changes its policy.





The FDA has also announced in a policy statement that it will not require that
genetically engineered agricultural products be labeled as such, provided that these products are as safe and have the same nutritional characteristics as conventionally developed products. The FDA may reconsider or change its labeling policies, or
local or state authorities may enact labeling requirements. Any such labeling requirements could reduce the demand for our products.





The
U.S. Department of Agriculture prohibits genetically engineered plants from being grown and transported except pursuant to an exemption, or under strict controls. If our future products are not exempted by the USDA, it may be impossible to sell such
products.





Adverse Events in the Field of Gene Therapy May Negatively Impact Regulatory Approval or Public Perception of Any Gene
Therapy Products We or Our Collaborators May Develop.





Currently, we are not engaged in developing gene therapy products; however, we
may engage in these activities in the future either for our own account or with collaborators. If we develop, or our collaborators develop, gene therapy products, these products may encounter substantial delays in development and approval due to the
government regulation and approval process. Adverse events reported in gene therapy clinical trials may lead to more government scrutiny of proposed clinical trials of gene therapy products, stricter labeling requirements for these products and
delays in the approval of gene therapy products for commercial sale.





The commercial success of any potential gene therapy products made
by us or our collaborators will depend in part on public acceptance of the use of gene therapies for the prevention or treatment of human diseases. Public attitudes may be influenced by claims that gene therapies are unsafe, and gene therapy
products may not gain the acceptance of the public or the medical community. Negative public reaction to gene therapy could result in a decrease in demand for any gene therapy products we or our collaborators may develop.





Health Care Reform and Restrictions on Reimbursements May Limit Our Returns on Pharmaceutical Products.





Our future products are expected to include pharmaceutical products. Our ability and that of our collaborators to commercialize pharmaceutical products developed
with our technologies may depend in part on the extent to which reimbursement for the cost of these products will be available from government health administration authorities, private health insurers and other organizations. Third-party payors are
increasingly challenging the price of medical products and services. Significant uncertainty exists as to the reimbursement status of newly approved health care products, and there can be no assurance that adequate third party coverage will be
available for any product to enable us to maintain price levels sufficient to realize an appropriate return on our investment in research and product development.





Destructive Actions By Activists or Terrorists Could Damage Our Facilities, Interfere with Our Research Activities and Cause Ecological Harm. Any Such Adverse Events Could Damage Our Ability to
Develop Products and Generate Adequate Revenue to Continue Operations.





Activists and terrorists have recently shown a willingness to
injure people and damage physical facilities, equipment and biological materials to publicize and/or further their ideological causes. Recent events in New York City and Washington, D.C. show that the amount of damage people are willing and able to
cause can be considerable. Our operations and research activities could be adversely impacted depending upon the nature and extent of such acts. Such damage could include disability or death of our personnel, damage to our physical facilities,
destruction of animals and biological materials, disruption of our communications and/or data management software used for research and/or destruction of research records. Any such damage could delay our research projects and decrease our ability to
conduct future research and development. Damage caused by activist and/or terrorist incidents could also cause the release of hazardous materials, including chemicals, radioactive and biological materials, which could damage our reputation in the
community. Clean up of any such releases could also be time consuming and costly.




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Any significant interruptions in our ability to conduct our business operations or research and
development activities could reduce our revenue and increase our expenses.





We Use Hazardous Chemicals and Radioactive and Biological
Materials in Our Business. Any Claims Relating to Improper Handling, Storage or Disposal of These Materials Could Be Time Consuming and Costly.





Our research and development processes involve the controlled use of hazardous materials, including chemicals, radioactive and biological materials. Some of these materials may be novel, including viruses with novel properties and
animal models for the study of viruses. Our operations also produce hazardous waste products. Some of our work also involves the development of novel viruses and viral animal models. We cannot eliminate the risk of accidental contamination or
discharge and any resultant injury from these materials. Federal, state and local laws and regulations govern the use, manufacture, storage, handling and disposal of these materials. We believe that our current operations comply in all material
respects with these laws and regulations. We could be subject to civil damages in the event of an improper or unauthorized release of, or exposure of individuals to, hazardous materials. In addition, claimants may sue us for injury or contamination
that results from our use or the use by third parties of these materials, and our liability may exceed our total assets. Compliance with environmental laws and regulations may be expensive, and current or future environmental regulations may impair
our research, development, or production efforts. We believe that our current operations comply in all material respects with applicable Environmental Protection Agency regulations.





In addition, certain of our collaborators are working with these types of hazardous materials in connection with our collaborations. To our knowledge, the work is performed in accordance with biosafety
regulations. In the event of a lawsuit or investigation, we could be held responsible for any injury caused to persons or property by exposure to, or release of, these viruses and hazardous materials. Further, under certain circumstances, we have
agreed to indemnify our collaborators against damages and other liabilities arising out of development activities or products produced in connection with these collaborations.





Our Collaborations With Outside Scientists May Be Subject to Change, Which Could Limit Our Access to Their Expertise.





We work with scientific advisors, consultants and collaborators at academic and other institutions. These scientists are not our employees and may have other commitments that could limit their
availability to us. Although our scientific advisors generally agree not to do competing work, if a conflict of interest between their work for us and their work for another entity arises, we may lose their services. Although our scientific advisors
and collaborators sign agreements not to disclose our confidential information, it is possible that certain of our valuable proprietary knowledge may become publicly known through them.





We May Be Sued for Product Liability.





We may be held liable if any
product we develop, or any product that is made with the use or incorporation of any of our technologies, causes injury or is found otherwise unsuitable during product testing, manufacturing, marketing or sale. These risks are inherent in the
development of chemical, agricultural and pharmaceutical products. Although we intend in the future to obtain product liability insurance, we do not have such insurance currently. Any such insurance that we seek to obtain may be prohibitively
expensive or may not fully cover our potential liabilities. Inability to obtain sufficient insurance coverage at an acceptable cost or otherwise to protect against potential product liability claims could prevent or inhibit the commercialization of
products developed by us or our collaborators. If we are sued for any injury caused by our products, our liability could exceed our total assets.





Our Stock Price Has Been, and May Continue to Be, Extremely Volatile.





The trading prices of life science company
stocks in general, and ours in particular, have experienced extreme price fluctuations in the last two years. The valuations of many life science companies without consistent product revenues and earnings, including ours, are high based on
conventional valuation standards such as price to earnings and price to sales ratios. These trading prices and valuations may not be sustained. Any negative change in the publics perception of the prospects of biotechnology or life science
companies could depress our stock price regardless of our results of operations. Other broad




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market and industry factors may decrease the trading price of our common stock, regardless of our performance. Market fluctuations, as well as
general political and economic conditions such as recession or interest rate or currency rate fluctuations, also may decrease the trading price of our common stock. In addition, our stock price could be subject to wide fluctuations in response to
factors including the following:





| |  |  | announcements of new technological innovations or new products by us or our competitors;
| | - |  | ----------------------------------------------------------------------------------------

| |  |  | changes in financial estimates by securities analysts;
| | - |  | ------------------------------------------------------

| |  |  | conditions or trends in the biotechnology and life science industries;
| | - |  | ----------------------------------------------------------------------

| |  |  | changes in the market valuations of other biotechnology or life science companies;
| | - |  | ----------------------------------------------------------------------------------

| |  |  | developments in domestic and international governmental policy or regulations;
| | - |  | ------------------------------------------------------------------------------

| |  |  | announcements by us or our competitors of significant acquisitions, strategic partnerships, joint ventures or capital commitments;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------

| |  |  | developments in or challenges relating to patent or other proprietary rights;
| | - |  | -----------------------------------------------------------------------------

| |  |  | period-to-period fluctuations in our operating results;
| | - |  | -------------------------------------------------------

| |  |  | future royalties from product sales, if any, by our strategic partners; and
| | - |  | ---------------------------------------------------------------------------

| |  |  | sales of our common stock or other securities in the open market.
| | - |  | -----------------------------------------------------------------




In the past, stockholders have often instituted securities class action litigation after periods of volatility in the market price of a companys securities. If a stockholder files a securities
class action suit against us, we would incur substantial legal fees and our managements attention and resources would be diverted from operating our business to respond to the litigation.





In December 2001 a lawsuit was filed in the U.S. District Court for the Southern District of New York against Maxygen, our chief executive officer, Russell Howard, and our then chief
financial officer (now president), Simba Gill, together with certain underwriters of our initial public offering and secondary public offering of common stock. The lawsuit, which alleges claims under Sections 11, 12(a)(2) and 15 of the Securities
Act of 1933 and Section 10(b) of the Securities Exchange Act of 1934, is among the so-called laddering cases that have been commenced against a number of companies that had public offerings of securities prior to December 2000. The
complaint has been consolidated with other laddering claims in a proceeding styled In re Initial Public Offering Securities Litigation, No. 21 MC 92 (SAS), pending before the Honorable Shira A. Scheindlin. An amended complaint was served on
Maxygen and Drs. Howard and Gill in April 2002. We believe the lawsuit against Maxygen and its officers is without merit and intend to defend against it vigorously.





We Expect that Our Quarterly Results of Operations Will Fluctuate, and This Fluctuation Could Cause Our Stock Price to Decline.





Our quarterly operating results have fluctuated in the past and are likely to do so in the future. These fluctuations could cause our stock price to fluctuate significantly or decline. Some of the
factors that could cause our operating results to fluctuate include:





| |  |  | expiration of research contracts with collaborators or government research grants, which may not be renewed or replaced;
| | - |  | ------------------------------------------------------------------------------------------------------------------------

| |  |  | the success rate of our discovery efforts leading to milestones and royalties;
| | - |  | ------------------------------------------------------------------------------

| |  |  | the timing and willingness of collaborators to commercialize our products, which would result in royalties; and
| | - |  | ---------------------------------------------------------------------------------------------------------------

| |  |  | general and industry specific economic conditions, which may affect our collaborators research and development expenditures.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------




A large portion of our expenses are relatively fixed, including expenses for facilities, equipment and personnel. Accordingly, if
revenues decline or do not grow as anticipated due to expiration of research contracts or government research grants, failure to obtain new contracts or other factors, we may not be able to correspondingly reduce our operating expenses. Failure to
achieve anticipated levels of revenues could therefore significantly harm our operating results for a particular fiscal period.





Due to
the possibility of fluctuations in our revenues and expenses, we believe that quarter-to-quarter comparisons of our operating results are not a good indication of our future performance. Our operating results in some quarters may not meet the
expectations of stock market analysts and investors. In that case, our stock price would likely decline.




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Some of Our Existing Stockholders Can Exert Control Over Us, and May Not Make Decisions that Are in
the Best Interests of All Stockholders.





Our executive officers, directors and principal stockholders together control approximately
35% of our outstanding common stock, including GlaxoSmithKline plc, which owns approximately 19% of our outstanding common stock. As a result, these stockholders, if they act together, and GlaxoSmithKline plc by itself, are able to exert a
significant degree of influence over our management and affairs and over matters requiring stockholder approval, including the election of directors and approval of significant corporate transactions. In addition, this concentration of ownership may
delay or prevent a change in control of Maxygen and might affect the market price of our common stock, even when a change may be in the best interests of all stockholders. In addition, the interests of this concentration of ownership may not always
coincide with our interests or the interests of other stockholders and accordingly, they could cause us to enter into transactions or agreements that we would not otherwise consider.




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ITEM 3


QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK





We are exposed to financial market risks, including changes in interest rates and foreign currency exchange. To mitigate some of these risks, we utilize currency forward contracts. We do not use
derivative financial instruments for speculative or trading purposes.





Interest Rate Risk





The primary objective of our investment activities is to preserve principal while at the same time maximizing yields without significantly increasing risk. To
achieve this objective, we maintain our portfolio of cash equivalents, short-term and long-term investments in a variety of securities, including corporate obligations and money market funds. All securities are held in U.S. currency. As of June 30,
2002, approximately 99% of our total portfolio will mature in one year or less, with the remainder maturing in less than two years.





The
following table represents the fair value balance of our cash, cash equivalents, short-term and long-term investments that are subject to interest rate risk by year of expected maturity and average interest rates as of June 30, 2002 (dollars in
thousands):





Expected Maturity2002


2003Cash and cash equivalents

$
109,034



Average interest rates


1.91
%


Short-term investments

$
73,654


$
36,226Average interest rates


4.03
%


4.20
%Long-term investments





$
2,540Average interest rates






2.87
%





We did not hold derivative instruments intended to mitigate interest rate risk as of June
30, 2002, and we have never held such instruments in the past. In addition, we had outstanding debt related to equipment financing of $993,000 as of June 30, 2002, with a range of interest rates of between 11.73% and 12.78%.





Foreign Currency Exchange Risk





A majority
of our revenue, expense and capital purchasing activities are transacted in U.S. dollars. However, in 2000 we acquired a wholly-owned subsidiary in Denmark, Maxygen ApS. The functional currency of Maxygen ApS is the Danish kroner. To protect against
reductions in value and the volatility of future cash flows caused by changes in foreign exchange rates, we have established a cash flow hedging program. Currency forward contracts are utilized in these hedging programs. Our hedging programs reduce,
but do not always eliminate, the impact of foreign currency exchange rate movements. Gains and losses on these foreign currency investments would generally be offset by corresponding losses and gains on the related hedging instruments, resulting in
negligible net exposure to Maxygen.





At June 30, 2002 we had a total of $6.3 million committed in foreign currency cash flow forward
contracts.




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PART II  OTHER INFORMATION





ITEM 1


LEGAL PROCEEDINGS





Not applicable.





ITEM 2


CHANGES IN SECURITIES AND USE OF PROCEEDS





Recent Sales of Unregistered Securities





Between April 20, 2002 and June 30, 2002 we issued a total of
43,192 shares of our common stock to a total of eight consultants in partial payment for consulting services rendered to us. On June 1, 2002 we issued a total of 12,413 shares of our common stock in connection with the acquisition of a license of
certain technology. There was no underwriter employed in connection with any of the above described transactions. The issuances of securities were deemed to be exempt from registration under the Securities Act of 1933, as amended (the
Securities Act) in reliance upon Section 4(2) of the Securities Act and Regulation D promulgated thereunder as transactions by an issuer not involving a public offering. The recipients of the securities represented their intentions to
acquire the securities for investment only and not with a view to or for sale in connection with any distribution thereof and appropriate legends were affixed to the share certificates issued in the transactions. The recipients either received
adequate information about us or had access, through employment or other relationships, to such information. The recipients, either alone or together with their duly appointed purchaser representatives, were knowledgeable, sophisticated and
experienced in making investment decisions of this kind and received adequate information about us.





Application of Initial Public
Offering Proceeds





The effective date of our first registration statement, filed on Form S-1 under the Securities Act (No. 333-89413)
relating to our initial public offering of common stock, was December 15, 1999. Net proceeds to us were approximately $101.0 million. From the effective date through June 30, 2002, the proceeds were applied toward:





| |  |  | purchases and installation of equipment and build-out of facilities, $18.0 million;
| | - |  | -----------------------------------------------------------------------------------




| |  |  | repayment of indebtedness, $1.0 million;
| | - |  | ----------------------------------------




| |  |  | working capital, $39.1 million; and
| | - |  | -----------------------------------




| |  |  | temporary investments in certificates of deposits, mutual funds and corporate debt securities, $42.9 million.
| | - |  | -------------------------------------------------------------------------------------------------------------




The use of the proceeds from the offering does not represent a material change in the use of the proceeds described in the registration statement.





ITEM 3


DEFAULTS UPON SENIOR SECURITIES





Not applicable.




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ITEM 4


SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS





We held our Annual Meeting of Stockholders on May 31, 2002. The following is a brief description of each matter voted upon at the meeting and the number of votes cast for, withheld, or against and the
number of abstentions with respect to each matter. Each director proposed by the Company was elected and the two management proposals were approved by the stockholders.





(a)    The stockholders reelected the seven nominees for the Companys Board of Directors:





Candidate

Shares Voted For Candidate



Shares WithheldRussell J. Howard

20,581,916



2,295,660Isaac Stein

22,425,235



452,341Robert J. Glaser

22,653,100



224,466M.R.C. Greenwood

22,655,354



222,222Ernest Mario

22,509,587



367,989George Poste

22,033,724



843,852Gordon Ringold

22,511,864



365,712





(b)    The stockholders approved the proposed amendment to the 1997
Stock Option Plan to restrict to 500,000 shares, the number of shares underlying options that may be granted to an optionee in any calendar year pursuant to the option plan:





Shares voted for

20,721,919Shares voted against

2,143,462Shares abstaining

12,195Broker non-votes

0





(c) The stockholders ratified the selection of Ernst & Young LLP as independent
auditors of the Company for the fiscal year ending December 31, 2002:





Shares voted for

22,621,769Shares voted against

244,983Shares abstaining

10,825Broker non-votes

0





ITEM 5


OTHER INFORMATION





Not
applicable.





ITEM 6


EXHIBITS AND REPORTS ON FORM 8-K





(a)    The following exhibits are filed as part of this report:





10.1

1997 Stock Option Plan, as amended, with applicable option agreement99.1

Certification of Chief Executive Officer and Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted
pursuant to Section 906 of the Sarbanes-Oxley Act of 2002





(b)    There were no reports on Form 8-K filed during the quarter
ended June 30, 2002.




32




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##### Table of Contents

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SIGNATURES





Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly
caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.





MAXYGEN, INC.August 13, 2002



By:

/s/    RUSSELL J. HOWARDRussell J. Howard Chief Executive Officer





August 13, 2002



By:

/s/    LAWRENCE W. BRISCOELawrence W. Briscoe Chief Financial Officer




33