----

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|   |  (Mark One)                                                                                 |   |
|--------|--------------------------------------------------------------------------------------------------|--------|
|   |  [ X ] ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |   |

|   |  [     ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |   |
|--------|---------------------------------------------------------------------------------------------------------------------------------|--------|

|   |  WaferGen Bio-systems, Inc.                             |   |
|--------|--------------------------------------------------------------|--------|
|   |  (Exact Name of Registrant as Specified in its Charter) |   |

|   |  Nevada                                                         |   | 90-0416683                              |   |
|--------|----------------------------------------------------------------------|--------|-----------------------------------------|--------|
|   |  (State or other jurisdiction of incorporation or organization) |   |  (IRS Employer Identification No.) |   |
|   |                                                                 |   |                                    |   |
|   |  7400 Paseo Padre Parkway, Fremont, CA                          |   |  94555                             |   |
|   |  (Address of principal executive offices)                       |   |  (Zip Code)                        |   |

|   | (510) 651-4450                                           |   |
|--------|----------------------------------------------------------|--------|
|   |  Registrant's telephone number, including area code |   |

| Title of each class: None |   |   | Name of each exchange on which registered: None |
|---------------------------|--------|--------|-------------------------------------------------|
|                      |   |   |                                            |

| Common stock, $0.001 par value per share |
|------------------------------------------|
| (Title of Class)                         |

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----

----

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|          | FORWARD LOOKING STATEMENTS                                                                     |   |   | 1      |   |
|---------------|------------------------------------------------------------------------------------------------|--------|--------|--------|--------|
|          |                                                                                           |   |   |   |   |
|          | PART III                                                                                       |   |   |   |   |
| ITEM 10.      | Directors, Executive Officers and Corporate Governance                                         |   |   | 2      |   |
| ITEM 11.      | Executive Compensation                                                                         |   |   | 6      |   |
| ITEM 12.      | Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters |   |   | 12     |   |
| ITEM 13.      | Certain Relationships and Related Transactions, and Director Independence                      |   |   | 14     |   |
| ITEM 14.      | Principal Accountant Fees and Services                                                         |   |   | 16     |   |
|          |                                                                                           |   |   |   |   |
|          | PART IV                                                                                        |   |   |   |   |
| ITEM 15.      | Exhibits and Financial Statement Schedules                                                     |   |   | 17     |   |
|          |                                                                                           |   |   |   |   |
| SIGNATURES    |                                                                                           |   |   | 20     |   |
|          |                                                                                           |   |   |   |   |
| EXHIBIT INDEX |                                                                                           |   |   | 21     |   |

----

----

|                  |   |   |   |     |
|-----------------------|--------|--------|--------|----------|
| Name                  |   | Age    |   | Position |
| Alnoor Shivji         |   |   | 53     |     | Chief Executive Officer, President and Chairman of the Board |
| Mona Chadha           |   |   | 50     |     | Executive Vice President, Marketing and Business Development, Chief Operating Officer and Secretary |
| Hector Brush          |   |   | 58     |     | Treasurer, Principal Financial Officer |
| Robert Coradini       |   |   | 50     |     | Director |
| Dr. Robert J. Hariri  |   |   | 51     |     | Director |
| Dr. R. Dean Hautamaki |   |   | 46     |     | Director |
| Makoto Kaneshiro      |   |   | 51     |     | Director |
| Joel Kanter           |   |   | 53     |     | Director |
| Nadine C. Smith       |   |   | 52     |     | Director |

----

----

----

| Name                  |   | No. of Late Reports |   | No. of TransactionsThat Were NotReported on aTimely Basis |   | Failure to Filea Required Form |
|-----------------------|--------|------------------------------------|--------|-----------------------------------------------------------------------------------------|--------|-----------------------------------------------|
| Dr. R. Dean Hautamaki |   | 1                                  |   | 1                                                                                       |   | 0                                             |
| Amjad Huda            |   | 0                                  |   | 0                                                                                       |   | 0                                             |
| Victor Joseph         |   | 0                                  |   | 0                                                                                       |   | 0                                             |
| Makoto Kaneshiro      |   | 1                                  |   | 1                                                                                       |   | 0                                             |
| Joel S. Kanter        |   | 1                                  |   | 1                                                                                       |   | 0                                             |
| Alnoor Shivji         |   | 3                                  |   | 4                                                                                       |   | 0                                             |
| Nadine C. Smith       |   | 3                                  |   | 4                                                                                       |   | 0                                             |
| Dr. Robert J. Hariri  |   | 1                                  |   | 2                                                                                       |   | 0                                             |
| Mona Chadha           |   | 0                                  |   | 0                                                                                       |   | 0                                             |
| Hector Brush          |   | 0                                  |   | 0                                                                                       |   | 0                                             |

| (1) | honest and ethical conduct, including the ethical handling of actual or apparent conflicts of interest between personal and professional relationships; |
|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------|

| (2) | full, fair, accurate, timely, and understandable disclosure in report and document that we file with, or submit to, the Security and Exchange Commission and in other public communications made by us; |
|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (3) | compliance with applicable government laws, rules and regulations; |
|-----|--------------------------------------------------------------------|

| (4) | the prompt internal reporting of violations of Code of Business Conduct and Ethics to an appropriate person or persons identified in the Code of Business Conduct and Ethics; and |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (5) | accountability for adherence to the Code of Business Conduct and Ethics. |
|-----|--------------------------------------------------------------------------|

----

| Name and Principal Position                                                                           |   | FiscalYear |   | Salary($) |    | Bonus($) |   | Option Awards($) |    | All OtherCompensation($) |   | Total($) |
|-------------------------------------------------------------------------------------------------------|--------|------------|--------|-----------|---------|----------|--------|-----------------------|---------|-------------------------------|--------|----------|
| Alnoor Shivji                                                                                         |   | 2009       |   | $         | 223,125 | (1)      |   | $                     | — | (2)                           |   | $        | — | (6) |   | $ | — |   |   | $ | 223,125 |   |
| Chairman, President and Chief Executive Officer                                                       |   | 2008       |   | $         | 253,854 | (1)      |   | $                     | 62,500  | (2),(3)                       |   | $        | 64,747 | (6) |   | $ | — |   |   | $ | 381,101 |   |
| Amjad Huda                                                                                            |   | 2009       |   | $         | 103,956 | (1)      |   | $                     | — | (2)                           |   | $        | 3,408 | (6) |   | $ | 180,882 | (7)   |   | $ | 288,246 |   |
| Former Chief Financial Officer                                                                        |   | 2008       |   | $         | 253,854 | (1)      |   | $                     | 62,500  | (2),(3)                       |   | $        | 28,902 | (6) |   | $ | — |   |   | $ | 345,256 |   |
| Victor Joseph                                                                                         |   | 2009       |   | $         | 103,956 | (1)      |   | $                     | — | (2)                           |   | $        | — | (6) |   | $ | 180,882 | (7) |   | $ | 284,838 |   |
| Former Chief Technology Officer                                                                       |   | 2008       |   | $         | 253,854 | (1)      |   | $                     | 62,500  | (2),(3)                       |   | $        | 33,982 | (6) |   | $ | — |   |   | $ | 350,336 |   |
| Mona Chadha                                                                                           |   | 2009       |   | $         | 212,609 | (4)      |   | $                     | — | (4)                           |   | $        | 102,783 | (6) |   | $ | — |   |   | $ | 315,392 |   |
| Executive Vice President of Marketing and Business Development, Chief Operating Officer and Secretary |   | 2008       |   | $         | 184,350 | (4)      |   | $                     | 45,000  | (2),(3)                       |   | $        | 29,238 | (6) |   | $ | — |   |   | $ | 258,588 |   |
| Hector Brush                                                                                          |   | 2009       |   | $         | 104,738 | (5)      |   | $                     | — | (5)                           |   | $        | — | (6) |   | $ | — |   |   | $ | 104,738 |   |
| Treasurer and Principal Financial Officer                                                             |   | 2008       |   | $         | 108,456 | (5)      |   | $                     | — | (5)                           |   | $        | 3,975 | (6) |   | $ | — |   |   | $ | 112,431 |   |

| (1) | Annual salary of $262,500 commenced on May 31, 2008, one year after the date of executive officer’s employment agreement with the Company.  On November 30, 2008 the Company adjusted the salary to $223,125  until the Company raises $5 million in gross proceeds from the sale of its securities in one or more financings on or prior to March 30, 2009, excluding any gross proceeds received in connection with any financings completed by its Malaysian subsidiary, WGBM; or (b) raises after March 30, 2009 funds sufficient to finance the Company’s operations at its then-current burn rate for an additional nine months after the closing of such financing, as reasonably determined by the compensation committee of the board of directors of the Company.  Salaries of Mr. Huda and Mr. Joseph were terminated in connection with their resignation as officers and directors of the Company effective June 17, 2009. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (2) | Under such executive officer’s, former executive officer’s or employee’s employment agreement, the executive officer, former executive officer or employee is or was entitled to a performance-based bonus of up to 25% of his or her salary.  No bonuses were paid for performance during fiscal year 2008 or 2009. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| (3)   | The Compensation Committee of the Board determined that each such executive, former executive or employee would receive a bonus in 2008 for his or her performance in 2007 equal to 25% of his or her base salary upon the completion of a financing transaction by the Company above a certain threshold amount.  This bonus was earned in fiscal year 2007, but paid in fiscal year 2008. |
|-----------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (4)  | Such officer became a Section 16B officer on March 20, 2009, and an annual salary of $225,000 commenced on that date pursuant to such executive officer’s employment agreement with the Company.  Under such officer’s amended employment agreement, the officer is entitled to a performance-based bonus of up to 40% of her salary.  No bonuses were paid for performance during fiscal year 2008 or 2009. |
|-----------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (5) | Such officer became a Section 16B officer effective June 18, 2009 and is entitled to an annual salary of $104,738.  He is not eligible for a bonus. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (6) | Amounts in this column reflect the aggregate grant date fair value of stock awards granted in the fiscal year computed in accordance with FASB ASC Topic 718 (rather than the dollar amount recognized for financial statement purposes for the fiscal year, excluding the impact of estimated forfeitures related to service-based vesting conditions, as previously required).  For more information, see Note 2, “Summary of Significant Accounting Policies--Stock-Based Compensation” and Note 7, “Stock Options and Warrants” to the Financial Statements contained in Item 8 in the Original Report.  The 2009 compensation expense for Amjad Huda and Victor Joseph excludes $60,481 and $61,073, respectively, being the dollar amount recognized for financial statement purposes resulting from the accelerated vesting of all of their outstanding options on June 17, 2009, in accordance with the terms of their separation agreements. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (7) | In connection with former executive officer’s separation agreement, the Company paid such former executive officer $180,882 in severance payments (including $40,385 for accrued vacation) in 2009, and will pay such former executive officer $165,651 in severance payments in 2010. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|     |   |                                                                 |    |                                                                       |   |                   |    |                 |
|---------------|--------|----------------------------------------------------------------------|---------|----------------------------------------------------------------------------|--------|------------------------|---------|----------------------|
| Name          |   | Number ofSecuritiesUnderlying UnexercisedOptionsExercisable (#) |    | Number ofSecuritiesUnderlyingUnexercisedOptionsUnexercisable (#) |   | OptionExercisePrice($) |    | OptionExpirationDate |
| Alnoor Shivji |   |                                                                 | 31,250  | (2)                                                                        |   |                   | 43,750  | (2)                  |   | $ | 1.95 |   |   |   | 4/17/2018 |   |
|          |   |                                                                 | 23,438  | (4)                                                                        |   |                   | 51,562  | (4)                  |   | $ | 1.35 |   |   |   | 9/30/2015 |   |
|          |   |                                                                 | 7,292   | (5)                                                                        |   |                   | 17,708  | (5)                  |   | $  | 1.00 |   |   |   | 10/24/2015 |   |
|          |   |                                                                 | 107,639 | (6)                                                                        |   |                   | 59,027  | (6)                  |   | $ | 1.50 |   |   |   | 5/31/2017 |   |
| Amjad Huda    |   |                                                                 | 25,000  | (2)                                                                        |   |                   | — |                 |   | $  | 1.95 |   |   |   | 6/17/2011 | (12) |
|          |   |                                                                 | 12,500  | (8)                                                                        |   |                   | — |                 |   | $ | 2.10 |   |   |   | 6/17/2011 | (12) |
|          |   |                                                                 | 37,500  | (4 )                                                                       |   |                   | — |                 |   | $ | 1.35 |   |   |   | 6/17/2011 | (12) |
|          |   |                                                                 | 20,000  | (5)                                                                        |   |                   | — |                 |   | $  | 1.00 |   |   |   | 6/17/2011 | (12) |
|     |   |                                                                 | 166,667 | (6)                                                                        |   |                   | — |                 |   | $ | 1.50 |   |   |   | 6/17/2011 | (12) |
|          |   |                                                                 | 134,979 | (7)                                                                        |   |                   | — |                 |   | $ | 0.46 |   |   |   | 6/17/2011 | (12) |
| Victor Joseph |   |                                                                 | 25,000  | (2)                                                                        |   |                   | — |                 |   | $  | 1.95 |   |   |   | 6/17/2011 | (12) |
|          |   |                                                                 | 12,500  | (3)                                                                        |   |                   | — |                 |   | $ | 2.10 |   |   |   | 6/17/2011 | (12) |
|          |   |                                                                 | 37,500  | (4)                                                                        |   |                   | — |                 |   | $  | 1.35 |   |   |   | 6/17/2011 | (12) |
|          |   |                                                                 | 20,000  | (5)                                                                        |   |                   | — |                 |   | $ | 1.00 |   |   |   | 6/17/2011 | (12) |
|          |   |                                                                 | 166,667 | (6)                                                                        |   |                   | — |                 |   | $  | 1.50 |   |   |   | 6/17/2011 | (12) |
|          |   |                                                                 | 134,979 | (7)                                                                        |   |                   | — |                 |   | $ | 0.46 |   |   |   | 6/17/2011 | (12) |
| Mona Chadha   |   |                                                                 | 59,954  | (9)                                                                        |   |                   | 10,235  | (9)                  |   | $  | 0.15 |   |   |   | 7/1/2016 |   |
|          |   |                                                                 | 10,417  | (2)                                                                        |   |                   | 14,583  | (2)                  |   | $ | 1.95 |   |   |   | 4/17/2018 |   |
|          |   |                                                                 | 15,625  | (4 )                                                                       |   |                   | 34,375  | (4)                  |   | $  | 1.35 |   |   |   | 9/30/2015 |   |
|          |   |                                                                 | 2,917   | (5)                                                                        |   |                   | 7,083   | (5)                  |   | $ | 1.00 |   |   |   | 10/24/2015 |   |
|          |   |                                                                 | — | (10)                                                                       |   |                   | 250,000 | (10)                 |   | $ | 1.10 |   |   |   | 3/20/2016 |   |
| Hector Brush  |   |                                                                 | 20,834  | (11)                                                                       |   |                   | 19,166  | (11)                 |   | $  | 1.56 |   |   |   | 11/15/2017 |   |
|          |   |                                                                 | 3,125   | (4 )                                                                       |   |                   | 6,875   | (4)                  |   | $ | 1.35 |   |   |   | 9/30/2015 |   |
|          |   |                                                                 | 1,021   | (5)                                                                        |   |                   | 2,479   | (5)                  |   | $  | 1.00 |   |   |   | 10/24/2015 |   |

----

| (1) | Option numbers and prices are presented as of December 31, 2009.  Upon the Merger, we adopted and assumed WaferGen’s 2003 Stock Incentive Plan and the then outstanding options automatically converted into options to purchase shares of our common stock using the same exchange ratio applied to convert the WaferGen shares into our common stock in the merger.  Upon the Merger, the vesting of all options issued under the 2003 Stock Incentive Plan was accelerated, and all the options became immediately exercisable. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (2) | Option to purchase shares of our common stock at an exercise price of $1.95 per share granted on April 17, 2008, which option vests with respect to the first 25% of the shares when the optionee completes 12 months of continuous service after the vesting start date, and with respect to an additional 1/48th of the shares when the optionee completes each full month of continuous service thereafter, and expires 10 years after the date of grant. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (3) | Option to purchase shares of our common stock at an exercise price of $2.10 per share granted on April 30, 2008, which option vests with respect to the first 25% of the shares when the optionee completes 12 months of continuous service after the vesting start date, and with respect to an additional 1/48th of the shares when optionee completes each full month of continuous service thereafter,   and expires 10 years after the date of grant.  |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| (4) | Option to purchase shares of our common stock at an exercise price of $1.35 per share granted on September 30, 2008, which option vests with respect to the first 25% of the shares when the optionee completes 12 months of continuous services after the vesting start date, and with respect to an additional 1/48th of the shares when optionee completes each full month of continuous service thereafter, and expires 7 years after the date of grant.          |

| (5) | Option to purchase shares of our common stock at an exercise price of $1.00 per share granted on October 24, 2008, which option vests with respect to the first 25% of the shares when the optionee completes 12 months of continuous service after the vesting start date, and with respect to an additional 1/48th of the shares when optionee completes each full month of continuous service thereafter, and expires 7 years after the date of grant. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (6) | Option to purchase shares of our common stock at an exercise price of $1.50 per share granted on May 31, 2007, which option vests in equal monthly installments over four years and expires 10 years after the date of grant. |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (7) | Option to purchase shares of our common stock at an exercise price of $0.46 per share granted on January 3, 2007 under the 2003 Stock Incentive Plan, which option became fully vested upon the Merger and expires 10 years after the date of grant. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (8) | Option to purchase our common stock at an exercise price of $2.10 per share granted on January 14, 2009, which option vests with respect to the first 25% of the shares when the optionee completes 12 months of continuous service after the vesting start date of April 30, 2008, and with respect to an additional 1/48th of the shares when optionee completes each full month of continuous service thereafter, and expires 7 years after the date of grant. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (9) | Option to purchase shares of our common stock at an exercise price of $0.15 per share granted on July 1, 2006, which option vests with respect to the first 25% of the shares when the optionee completes 12 months of continuous service after the vesting start date, and with respect to an additional 1/48th of the shares when the optionee completes each full month of continuous service thereafter, and expires 10 years after the date of grant. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (10) | Option to purchase our common stock at an exercise price of $1.10 per share granted on March 20, 2009, which option vests with respect to the first 25% of the shares when the optionee completes 12 months of continuous service after the vesting start date, and with respect to an additional 1/48th of the shares when optionee completes each full month of continuous service thereafter, and expires 7 years after the date of grant. |
|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (11) | Option to purchase shares of our common stock at an exercise price of $1.56 per share granted on November 15, 2007, which option vests with respect to the first 25% of the shares when the optionee completes 12 months of continuous service after the vesting start date, and with respect to an additional 1/48th of the shares when the optionee completes each full month of continuous service thereafter, and expires 10 years after the date of grant. |
|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (12) | In accordance with the terms of separation agreements, all of Amjad Huda’s and Victor Joseph’s options will now expire on June 17, 2011, two years after their resignation dates. |
|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

----

| (a)                   |   | (b)          |    |   | (c)    |   |    | (d)          |   |   | (e)          |   |   | (f)            |    |   | (g)            |   |    | (h)    |   |
|-----------------------|--------|--------------|---------|--------|--------|--------|---------|--------------|--------|--------|--------------|--------|--------|----------------|---------|--------|----------------|--------|---------|--------|--------|
|                  |   |         |    |   |   |   |    |         |   |   |         |   |   | Change in |    |   |           |   |    |   |   |
|                  |   |         |    |   |   |   |    |         |   |   |         |   |   | Pension        |    |   |           |   |    |   |   |
|                  |   | Fees         |    |   |   |   |    |         |   |   |         |   |   | Value and |    |   |           |   |    |   |   |
|                  |   | Earned       |    |   |   |   |    |         |   |   | Non-Equity   |   |   | Nonqualified   |    |   |           |   |    |   |   |
|                  |   | or Paid |    |   |   |   |    |         |   |   | Incentive    |   |   | Deferred       |    |   |           |   |    |   |   |
|                  |   | In           |    |   | Stock  |   |    | Option       |   |   | Plan         |   |   | Compensation   |    |   | All Other |   |    |   |   |
|                  |   | Cash         |    |   | Awards |   |    | Awards       |   |   | Compensation |   |   | Earnings       |    |   | Compensation   |   |    | Total  |   |
| Name                  |   | ($)          |    |   | ($)    |   |    | ($) (1) |   |   | ($)          |   |   | ($)            |    |   | ($)            |   |    | ($)    |   |
| Makoto Kaneshiro      |   | $            | — |   |   | $      | — |         |   | $      | 11,190       |   |   | $              | — |   |           | $      | — |   |   | $ | — |   |   | $ | 11,190 |   |
| Dr. R. Dean Hautamaki |   | $            | — |   |   | $      | — |         |   | $      | 11,190       |   |   | $              | — |   |           | $      | — |   |   | $ | — |   |   | $ | 11,190 |   |
| Joel Kanter           |   | $            | — |   |   | $      | — |         |   | $      | 11,190       |   |   | $              | — |   |           | $      | — |   |   | $ | — |   |   | $ | 11,190 |   |
| Nadine C. Smith       |   | $            | — |   |   | $      | — |         |   | $      | 11,190       |   |   | $              | — |   |           | $      | — |   |   | $ | — |   |   | $ | 11,190 |   |
| Dr. Robert Hariri     |   | $            | — |   |   | $      | — |         |   | $      | 23,424       |   |   | $              | — |   |           | $      | — |   |   | $ | — |   |   | $ | 23,424 |   |
| Robert Coradini       |   | $            | — |   |   | $      | — |         |   | $      | 29,561       |   |   | $              | — |   |           | $      | — |   |   | $ | — |   |   | $ | 29,561 |   |

|   (1) | The amounts shown in column (d) represent the aggregate grant date fair value of stock awards granted in 2009 computed in accordance with FASB ASC Topic 718. |
|------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | • | Each non-employee director will receive an initial option grant (the “Initial Grant”) of 40,000 stock options upon the director’s appointment to Board, with 50% of the options vested upon grant and the remaining 50% of the options vesting over one year with 25% of the options vesting every three months; provided, however, that the first Initial Grant made to non-employee directors in January 2008 was fully vested on the date of grant; and |
|--------|---------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | • | Immediately following each annual meeting of the Company’s stockholders commencing with the annual meeting of the Company’s stockholders in 2008, each non-employee director who continues as a non-employee director following such annual meeting shall receive an award of 15,000 stock options (the “Subsequent Grant”) vesting over one year with 25% of the option vesting every three months; provided that no Subsequent Grant shall be made to any non-employee director who has not served as a director of the Company, as of the time of such annual meeting, for at least six (6) months.  |
|--------|---------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|   | • | Each Initial Grant and each Subsequent Grant shall provide that in the event of a change in control of the Company, such option shall automatically become fully vested and no longer subject to forfeiture immediately prior to the specified effective date of such change in control.  The exercise price for all Initial Grants and Subsequent Grants shall be the fair market value of the Company’s Common Stock in accordance with the terms of the Company’s stock incentive plan.                                                                                                                     |

----

----

Item 12. 

|                                                      |   |               |      |                        |   | Number of       |   |
|-----------------------------------------------------------|--------|--------------------|-----------|-----------------------------|--------|----------------------|--------|
|                                                      |   |               |      |                        |   | Securities           |   |
|                                                      |   |               |      |                        |   | Remaining            |   |
|                                                      |   | Number of     |      |                        |   | Available for   |   |
|                                                      |   | Securities to |      |                        |   | Future Issuance |   |
|                                                      |   | Be                 |      |                        |   | Under Equity    |   |
|                                                      |   | Issued upon   |      |                        |   | Compensation         |   |
|                                                      |   | Exercise of   |      | Weighted-Average            |   | Plans                |   |
|                                                      |   | Outstanding        |      | Exercise Price of |   | (Excluding           |   |
|                                                      |   | Options,           |      | Outstanding                 |   | Securities           |   |
|                                                      |   | Warrants and  |      | Options, Warrants      |   | Reflected in    |   |
|                                                      |   | Rights             |      | and Rights             |   | Column (a))     |   |
| Plan Category                                             |   | (a)                |      | (b)                         |   | (c)                  |   |
| Equity compensation plans approved by security holder     |   |               | 4,149,402 |                        | $      | 1.42                 |   | $ | 1,437,979 |   |
| Equity compensation plans not approved by security holder |   |               | —   |                        |   | —              |   |   | — |   |
| Total                                                     |   |               | 4,149,402 |                        | $      | 1.42                 |   | $ | 1,437,979 |   |

|                                                    |   | Number of |      |         |   |
|---------------------------------------------------------|--------|----------------|-----------|--------------|--------|
|                                                    |   | Shares         |      | Percentage   |   |
|                                                    |   | Beneficially   |      | Beneficially |   |
| Name of Beneficial Owner                                |   | Owned          |      | Owned (1)    |   |
| William L. Collins                                      |   |           | 3,241,743 | (2)          |   | 9.36 | % |
| Mark Tompkins                                           |   |           | 2,314,026 | (3)          |   | 6.81 | % |
| The Shivji Family Trust dated June 12, 2000        |   |           | 1,987,086 | (4)          |   | 5.86 | % |
| CSK-VC Life Science Investment Fund LP                  |   |           | 1,768,186 | (5)          |   | 5.24 | % |
| Directors and Executive Officers:                       |   |           |      |         |   |   |   |
| Alnoor Shivji                                           |   |           | 5,079,492 | (6)          |   | 14.76 | % |
| Nadine C. Smith                                         |   |           | 1,044,436 | (7)          |   | 3.08 | % |
| Dr. R. Dean Hautamaki                                   |   |           | 388,373   | (8)          |   | 1.14 | % |
| Makoto Kaneshiro                                        |   |           | 186,533   | (9)          |   | * |   |
| Mona Chadha                                             |   |           | 185,394   | (10)         |   | * |   |
| Dr. Robert Hariri                                       |   |           | 170,769   | (11)         |   | * |   |
| Joel Kanter                                             |   |           | 167,500   | (12)         |   | * |   |
| Robert Coradini                                         |   |           | 160,769   | (13)         |   | * |   |
| Hector Brush                                            |   |           | 31,459    | (14)         |   | * |   |
| Directors and Executive Officers as a Group (9 persons) |   |           | 7,414,725 |         |   | 20.86 | % |

| * | Less than 1% |
|---|--------------|

----

| (1) | Based on 33,594,399 shares of our common stock issued and outstanding as of April 29, 2010. |
|-----|--------------------------------------------------------------------------------------------------|

| (2) | Share ownership based on beneficial owner’s S13-G/A filed February 29, 2010, and includes shares held by William L. Collins 2009 GRAT and affiliates of Brencourt Advisors, LLC.  Share percentage calculation includes 492,348 shares of common stock issuable upon the exercise of currently exercisable warrants held by William L. Collins 2009 GRAT and 474,309 shares of common stock issuable upon the exercise of currently exercisable warrants held by affiliates of Brencourt Advisors, LLC.  William L. Collins has voting control and investment power over, but disclaims beneficial ownership of, the securities managed owned by William L. Collins 2009 GRAT.  William L. Collins is the CEO and Managing Member of Brencourt Advisors, LLC, but lacks sole voting control and investment power over and disclaims beneficial ownership of the securities managed by Brencourt Advisors, LLC.  Brencourt Advisors, LLC’s and William L. Collins’s address is 600 Lexington Avenue, 8th Floor, New York, NY 10022. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (3) | Includes 305,400 shares of common stock issuable upon the exercise of currently exercisable warrants.  His address is c/o Gottbetter & Partners, 488 Madison Ave, 12th Floor, New York, NY 10022. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (4) | Includes 206,868 shares of common stock issuable upon the exercise of currently exercisable warrants.  Alnoor Shivji and his wife, Mariam Shivji, are the co-trustees of The Shivji Family Trust dated June 12, 2000 (“The Shivji Family Trust”).  Its address is 692 Hillcrest Terrace, Fremont, CA 94539.  See also footnote (6) in this section.  |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| (5) | Includes 50,000 shares of common stock issuable upon the exercise of currently exercisable warrants.  Hiromichi Tabata has the power to vote and dispose of the shares being registered on behalf of CSK-VC Life Science Investment Fund.  Its address is 5th Floor, Riviera Minami Aoyama Building, 3-3-3, Minami-Aoyama, Minato-Ku, Tokyo 107-0062 Japan.                          |

| (6) | Consists of (i) 2,424,561 shares of common stock, (ii) 290,555 shares of common stock issuable upon the exercise of currently exercisable warrants, (iii) 207,292 shares of common stock issuable upon the exercise of options that are exercisable within 60 days, (iv) 1,780,218 shares of common stock held by The Shivji Family Trust, (v) 206,868 shares of common stock issuable upon the exercise of currently exercisable warrants held by The Shivji Family Trust, (vi) 48,333 shares of common stock held by each of the Shivji Children’s Trust fbo Zahra Shivji, the Shivji Children’s Trust fbo Suraya Shivji and the Jameel Shivji Irrevocable Trust (the “Shivji Children’s Trusts”), and (vii) 8,333 shares of common stock issuable upon the exercise of currently exercisable warrants held by each of the three Shivji Children’s Trusts.  Mr. Shivji and his wife, Mariam Shivji, are the co-trustees of The Shivji Family Trust and each of the three Shivji Children’s Trusts (together, the “Shivji Trusts”).  Mr. Shivji disclaims beneficial ownership of the securities held by each of the Shivji Trusts, except to the extent he has a pecuniary interest therein.  Excludes options to purchase 134,374 shares of common stock that are not exercisable within 60 days.  See also footnote (4) in this section.  |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| (7) | Includes 170,836 shares of common stock issuable upon the exercise of currently exercisable warrants and 55,000 shares of common stock issuable upon the exercise of options that are exercisable within 60 days.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |

| (8) | Consists of (i) 255,625 shares of common stock issuable upon the exercise of options that are exercisable within 60 days, (ii) 110,633 shares of common stock held by Cojack Investment Opportunities, LLC (“Cojack”), and (iii) 22,115 shares of common stock issuable upon the exercise of currently exercisable warrants held by Cojack.  Excludes options to purchase 94,375 shares of common stock that are not exercisable within 60 days. |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (9)   | Consists of 186,533 shares of common stock issuable upon the exercise of options that are exercisable within 60 days.  Excludes options to purchase 2,249 shares of common stock that are not exercisable within 60 days.   |
|-----------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| (10)            | Consists of 185,394 shares of common stock issuable upon the exercise of options that are exercisable within 60 days.  Excludes options to purchase 219,795 shares of common stock that are not exercisable within 60 days. |

| (11) | Includes 30,769 shares of common stock issuable upon the exercise of currently exercisable warrants and 40,000 shares of common stock issuable upon the exercise of options that are exercisable within 60 days. |
|------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| (12) | Includes (i) 70,000 shares of common stock issuable upon the exercise of options that are exercisable within 60 days, (ii) 75,000 shares of common stock held by the Kanter Family Foundation and (iii) 22,500 shares of common stock issuable upon exercise of currently exercisable warrants held by the Kanter Family Foundation.  Joel Kanter and his brother, Joshua Kanter, have voting and dispositive power over all of the securities held by the Kanter Family Foundation.  Mr. Kanter disclaims beneficial ownership of the securities held by the Kanter Family Foundation, except to the extent he has a pecuniary interest therein.  |
|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| (13) | Includes 30,769 shares of common stock issuable upon the exercise of currently exercisable warrants and 30,000 shares of common stock issuable upon the exercise of options that are exercisable within 60 days.  Excludes options to purchase 10,000 shares of common stock that are not exercisable within 60 days.                                                                                                                                                                                                                                                                                                                                             |
| (14) | Consists of 31,459 shares of common stock issuable upon the exercise of options that are exercisable within 60 days.  Excludes options to purchase 22,041 shares of common stock that are not exercisable within 60 days.                                                                                                                                                                                                                                                                                                                                                                                                                                              |

Item 13. 

----

| ISSUER PURCHASES OF EQUITY SECURITIES (1) |
|-------------------------------------------|
| Period                                    |   | (a) Total Numberof SharesPurchased |   | (b) AveragePrice Paidper Share |   | (c) Total Number ofShares Purchased as Partof Publicly AnnouncedPlans or Programs |   | (d) Maximum Number ofShares that May Yet BePurchased Under the Plansor Programs (2) |
| Month #1 (Dec. 1- Dec. 31, 2008)          |   | 16,693 |   | $0.99 |   | 16,693 |   | 232,500 |
| Month #2 (Jan. 1- Jan. 31, 2009)          |   | 43,869 |   | $1.12 |   | 43,869 |   | 188,631 |
| Month #3 (Feb. 1- Feb. 28, 2009)          |   | 44,534 |   | $1.20 |   | 44,534 |   | 144,097 |
| Month #4 (Mar. 1- Mar. 31, 2009)          |   | 10,337 |   | $1.23 |   | 10,337 |   | — |
| Total                                     |   | 115,433 |   | $1.14 |   | 115,433 |   | — |

| (1) | The Company did not purchase any shares of its common stock during 2008 or 2009. |
|-----|----------------------------------------------------------------------------------|

| (2) | As of March 31, 2009.  As of the date of this prospectus, no additional shares may be purchased under the Rule 10b5-1 Plans. |
|-----|---------------------------------------------------------------------------------------------------------------------------------------------|

----

Item 14. 

|               |   |   | 2009    |   |   |   | 2008    |   |
|--------------------|--------|--------|---------|--------|--------|--------|---------|--------|
| Audit fees         |   | $      | 180,280 |   |   | $      | 98,194  |   |
| Audit related fees |   |   | 81,214  |   |   |   | 39,271  |   |
| Tax fees           |   |   | 20,193  |   |   |   | 24,586  |   |
| All other fees     |   |   | — |   |   |   | — |   |
| Total Fees         |   | $      | 281,687 |   |   | $      | 162,051 |   |

----

| ·   | should not in all instances be treated as categorical statements of fact, but rather as a way of allocating the risk to one of the parties if those statements prove to be inaccurate; |
|--------------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| ·   | have been qualified by disclosures that were made to the other party in connection with the negotiation of the applicable agreement, which disclosures are not necessarily reflected in the agreement; |
|--------------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| ·   | may apply standards of materiality in a way that is different from what may be viewed as material to you or other investors; and |
|--------------------|----------------------------------------------------------------------------------------------------------------------------------|

| ·   | were made only as of the date of the applicable agreement or such other date or dates as may be specified in the agreement and are subject to more recent developments. |
|--------------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| Exhibit      |   |                                                                                                                                              |   | Filed    |   | Incorporated by Reference |
|--------------|--------|---------------------------------------------------------------------------------------------------------------------------------------------------|--------|----------|--------|-------------------------------------|
| Number       |   | Exhibit Description                                                                                                                               |   | Herewith |   | Form                                |   | Period Ending |   | Exhibit |   | Filing Date |
|         |   |                                                                                                                                              |   |     |   |                                |   |   |   |   |   |   |
| 2.1          |   | Agreement and Plan of Merger and Reorganization, dated as of May 31, 2007, by and among WBSI, WaferGen Acquisition Corp., and WaferGen, Inc. |   |     |   | 8-K                                 |   |   |   | 2.1 |   | 6/5/2007 |
|         |   |                                                                                                                                              |   |     |   |                                |   |   |   |   |   |   |
| 2.2          |   | Certificate of Merger of WaferGen Acquisition Corp. with and into WaferGen, Inc., dated May 31, 2007                                         |   |     |   | 8-K                                 |   |   |   | 2.2 |   | 1/16/2008 |
|         |   |                                                                                                                                              |   |     |   |                                |   |   |   |   |   |   |
| 3.1          |   | Certificate of Incorporation of WBSI                                                                                                              |   |     |   | SB-2                                |   |   |   | 3.1 |   | 8/9/2006 |
|         |   |                                                                                                                                              |   |     |   |                                |   |   |   |   |   |   |
| 3.2          |   | Certificate of Amendment to the Certificate of Incorporation of WBSI, dated January 31, 2007                                                 |   |     |   | 8-K                                 |   |   |   | 3.1 |   | 2/1/2007 |
|         |   |                                                                                                                                              |   |     |   |                                |   |   |   |   |   |   |
| 3.3          |   | Bylaws of WBSI                                                                                                                                    |   |     |   | SB-2                                |   |   |   | 3.2 |   | 8/9/2006 |
|         |   |                                                                                                                                              |   |     |   |                                |   |   |   |   |   |   |
| 4.1          |   | Lockup Agreement dated January 14, 2008, among WBSI, Rodman & Renshaw LLC and R&R Biotech Partners LLC                               |   |     |   | SB-2/A                              |   |   |   | 4.1 |   | 1/16/2008 |
|         |   |                                                                                                                                              |   |     |   |                                |   |   |   |   |   |   |
| 10.1 † |   | Form of Warrants, made as of May 5, 2007, to purchase up to an aggregate of 115,424 shares of WBSI’s Common Stock                      |   |     |   | 10-K                                |   | 12/31/2009 |   | 10.1 |   | 3/22/2010 |
|         |   |                                                                                                                                              |   |     |   |                                |   |   |   |   |   |   |
| 10.2         |   | Form of Common Stock Purchase Warrant issued to investors in a private placement, the initial closing of which was held on May 31, 2007      |   |     |   | 8-K                                 |   |   |   | 10.21 |   | 6/5/2007 |

----

| Exhibit       |   |                                                                                                                                                                                                                                                                                                          |   | Filed    |   | Incorporated by Reference |
|---------------|--------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|----------|--------|-------------------------------------|
| Number        |   | Exhibit Description                                                                                                                                                                                                                                                                                           |   | Herewith |   | Form                                |   | Period Ending |   | Exhibit |   | Filing Date |
|          |   |                                                                                                                                                                                                                                                                                                          |   |     |   |                                |   |   |   |   |   |   |
| 10.3          |   | Form of Warrant issued to Placement Agent in connection with a private placement, the initial closing of which was held on May 31, 2007                                                                                                                                                                  |   |     |   | 8-K                                 |   |   |   | 10.22 |   | 6/5/2007 |
|          |   |                                                                                                                                                                                                                                                                                                          |   |     |   |                                |   |   |   |   |   |   |
| 10.4 †  |   | Employment Agreement dated May 31, 2007, between WBSI and Alnoor Shivji                                                                                                                                                                                                                                  |   |     |   | 8-K                                 |   |   |   | 10.26 |   | 6/5/2007 |
|          |   |                                                                                                                                                                                                                                                                                                          |   |     |   |                                |   |   |   |   |   |   |
| 10.5          |   | Securities Purchase Agreement, dated May 19, 2008, by and among WaferGen Bio-systems, Inc. and the purchasers identified on the signature pages thereto                                                                                                                                                  |   |     |   | 8-K                                 |   |   |   | 10.1 |   | 5/21/2008 |
|          |   |                                                                                                                                                                                                                                                                                                          |   |     |   |                                |   |   |   |   |   |   |
| 10.6          |   | Form of Common Stock Purchase Warrant issued to investors identified in the Securities Purchase Agreement dated May 19, 2008                                                                                                                                                                             |   |     |   | 8-K                                 |   |   |   | 10.2 |   | 5/21/2008 |
|          |   |                                                                                                                                                                                                                                                                                                          |   |     |   |                                |   |   |   |   |   |   |
| 10.7 †  |   | WaferGen Bio-Systems, Inc. 2008 Stock Incentive Plan                                                                                                                                                                                                                                                          |   |     |   | 8-K                                 |   |   |   | 10.1 |   | 7/3/2008 |
|          |   |                                                                                                                                                                                                                                                                                                          |   |     |   |                                |   |   |   |   |   |   |
| 10.8 †  |   | Form of Non-Qualified Stock Option award under 2008 Stock Incentive Plan                                                                                                                                                                                                                                      |   |     |   | 10-K                                |   | 12/31/2008 |   | 10.35 |   | 3/27/2009 |
|          |   |                                                                                                                                                                                                                                                                                                          |   |     |   |                                |   |   |   |   |   |   |
| 10.9          |   | Share Subscription Agreement and Shareholders’ Agreement dated May 8, 2008, by and among WaferGen Bio-systems, Inc., Malaysian Technology Development Corporation Sdn. Bhd. and WaferGen Biosystems (M) Sdn. Bhd.                                                                                  |   |     |   | 10-Q                                |   | 9/30/2008 |   | 10.1 |   | 11/14/2008 |
|          |   |                                                                                                                                                                                                                                                                                                          |   |     |   |                                |   |   |   |   |   |   |
| 10.10         |   | Put Agreement dated May 28, 2008, by and among WaferGen Bio-systems, Inc. and Holders of the Series A Redeemable Convertible Preference Shares in WaferGen Biosystems (M) Sdn. Bhd.                                                                                                                      |   |     |   | 10-Q                                |   | 9/30/2008 |   | 10.2 |   | 11/14/2008 |
|          |   |                                                                                                                                                                                                                                                                                                          |   |     |   |                                |   |   |   |   |   |   |
| 10.11         |   | Put Option Agreement dated May 28, 2008, by and among Alnoor Shivji and Malaysian Technology Development Corporation Sdn. Bhd.                                                                                                                                                                           |   |     |   | 10-Q                                |   | 9/30/2008 |   | 10.3 |   | 11/14/2008 |
|          |   |                                                                                                                                                                                                                                                                                                          |   |     |   |                                |   |   |   |   |   |   |
| 10.12 † |   | Letter Agreement dated January 16, 2009, by and between WBSI and Alnoor Shivji                                                                                                                                                                                                                           |   |     |   | 10-K                                |   | 12/31/2008 |   | 10.39 |   | 3/27/2009 |
|          |   |                                                                                                                                                                                                                                                                                                          |   |     |   |                                |   |   |   |   |   |   |
| 10.13         |   | Form of WBSI Distribution Agreement                                                                                                                                                                                                                                                                           |   |     |   | 10-K                                |   | 12/31/2008 |   | 10.42 |   | 3/27/2009 |
|          |   |                                                                                                                                                                                                                                                                                                          |   |     |   |                                |   |   |   |   |   |   |
| 10.14         |   | Share Subscription Agreement dated April 3, 2009, by and among WaferGen Bio-systems, Inc., WaferGen Biosystems (M) Sdn. Bhd., Primar Mahawangsa Sdn. Bhd. and Expedient Equity Ventures Sdn. Bhd.                                                                                                        |   |     |   | 8-K                                 |   |   |   | 10.1 |   | 4/14/2009 |
|          |   |                                                                                                                                                                                                                                                                                                          |   |     |   |                                |   |   |   |   |   |   |
| 10.15         |   | Put Agreement dated April 3, 2009, by and among WaferGen Bio-systems, Inc. and Holders of Series B Redeemable Convertible Preference Shares in WaferGen Biosystems (M) Sdn. Bhd.                                                                                                                         |   |     |   | 8-K                                 |   |   |   | 10.2 |   | 4/14/2009 |
|          |   |                                                                                                                                                                                                                                                                                                          |   |     |   |                                |   |   |   |   |   |   |
| 10.16         |   | Form of Put Option Agreement dated April 3, 2009, by and among Alnoor Shivji and Holders of Series B Redeemable Convertible Preference Shares in WaferGen Biosystems (M) Sdn. Bhd.                                                                                                                       |   |     |   | 8-K                                 |   |   |   | 10.3 |   | 4/14/2009 |
|          |   |                                                                                                                                                                                                                                                                                                          |   |     |   |                                |   |   |   |   |   |   |
| 10.17         |   | Deed of Adherence to the Share Subscription and Shareholders’ Agreement dated May 8, 2008, by and among WaferGen Bio-systems, Inc., WaferGen Biosystems (M) Sdn. Bhd., Primar Mahawangsa Sdn. Bhd., Expedient Equity Ventures Sdn. Bhd. and Malaysian Technology Development Corporation Sdn. Bhd. |   |     |   | 10-Q                                |   | 3/31/2009 |   | 10.4 |   | 5/12/2009 |
|          |   |                                                                                                                                                                                                                                                                                                          |   |     |   |                                |   |   |   |   |   |   |
| 10.18         |   | Form of Subscription Agreement between WaferGen Bio-systems, Inc., and the investors party thereto in connection with the Company’s 2009 private placement offering of units of securities                                                                                                              |   |     |   | 10-Q                                |   | 6/30/2009 |   | 10.5 |   | 8/10/2009 |
|          |   |                                                                                                                                                                                                                                                                                                          |   |     |   |                                |   |   |   |   |   |   |
| 10.19         |   | Form of Warrants to purchase shares of Common Stock of the Company, issued June 16, 2009, to investors in the Company’s 2009 private placement offering of units of securities                                                                                                                     |   |     |   | 10-Q                                |   | 6/30/2009 |   | 10.6 |   | 8/10/2009 |
|          |   |                                                                                                                                                                                                                                                                                                          |   |     |   |                                |   |   |   |   |   |   |
| 10.20         |   | Registration Rights Agreement, dated June 16, 2009, between WaferGen Bio-systems, Inc., and the investors party thereto in connection with the Company’s 2009 private placement offering of units of securities                                                                                    |   |     |   | 10-Q                                |   | 6/30/2009 |   | 10.7 |   | 8/10/2009 |
|          |   |                                                                                                                                                                                                                                                                                                          |   |     |   |                                |   |   |   |   |   |   |
| 10.21         |   | Form of Warrant to purchase shares of Common Stock of the Company, issued to Spencer Trask Ventures, Inc. and certain related parties in connection with the Company’s 2009 private placement offering of units of securities                                                                           |   |     |   | 10-Q                                |   | 6/30/2009 |   | 10.8 |   | 8/10/2009 |
|          |   |                                                                                                                                                                                                                                                                                                          |   |     |   |                                |   |   |   |   |   |   |
| 10.22 † |   | Employment Separation Agreement, dated June 17, 2009, by and among Amjad Huda and WaferGen Bio-systems, Inc.                                                                                                                                                                                             |   |     |   | 10-K                                |   | 12/31/2009 |   | 10.22 |   | 3/22/2010 |

----

| Exhibit       |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   | Filed    |   | Incorporated by Reference |
|---------------|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|----------|--------|-------------------------------------|
| Number        |   | Exhibit Description                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |   | Herewith |   | Form                                |   | Period Ending |   | Exhibit |   | Filing Date |
|          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   |     |   |                                |   |   |   |   |   |   |
|          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   |     |   |                                |   |   |   |   |   |   |
| 10.23 † |   | Employment Separation Agreement, dated June 17, 2009, by and among Victor Joseph and WaferGen Bio-systems, Inc.                                                                                                                                                                                                                                                                                                                                                                   |   |     |   | 10-K                                |   | 12/31/2009 |   | 10.23 |   | 3/22/2010 |
|          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   |     |   |                                |   |   |   |   |   |   |
| 10.24         |   | Share Subscription Agreement dated July 1, 2009, by and among WaferGen Bio-systems, Inc., WaferGen Biosystems (M) Sdn. Bhd. and Kumpalan Modal Perdana Sdn. Bhd.                                                                                                                                                                                                                                                                                                                  |   |     |   | 10-Q                                |   | 9/30/2009 |   | 10.1 |   | 11/13/2009 |
|          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   |     |   |                                |   |   |   |   |   |   |
| 10.25         |   | Put Agreement dated July 1, 2009, by and among WaferGen Bio-systems, Inc. and Holders of Series B Redeemable Convertible Preference Shares in WaferGen Biosystems (M) Sdn. Bhd.                                                                                                                                                                                                                                                                                                   |   |     |   | 10-Q                                |   | 9/30/2009 |   | 10.2 |   | 11/13/2009 |
|          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   |     |   |                                |   |   |   |   |   |   |
| 10.26         |   | Put Option Agreement dated July 1, 2009, by and among Alnoor Shivji and Kumpalan Modal Perdana Sdn. Bhd.                                                                                                                                                                                                                                                                                                                                                                          |   |     |   | 10-Q                                |   | 9/30/2009 |   | 10.3 |   | 11/13/2009 |
|          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   |     |   |                                |   |   |   |   |   |   |
| 10.27         |   | Deed of Adherence dated July 1, 2009, to the Share Subscription and Shareholders’ Agreement dated May 8, 2008, and the Share Subscription Agreement dated April 3, 2009, by and among WaferGen Bio-systems, Inc., WaferGen Biosystems (M) Sdn. Bhd., Primar Mahawangsa Sdn. Bhd., Expedient Equity Ventures Sdn. Bhd., Malaysian Technology Development Corporation Sdn. Bhd. and Kumpalan Modal Perdana Sdn. Bhd.                                                |   |     |   | 10-Q                                |   | 9/30/2009 |   | 10.4 |   | 11/13/2009 |
|          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   |     |   |                                |   |   |   |   |   |   |
| 10.28 † |   | Employment Agreement, effective October 29, 2009, by and between the Company and Mona Chadha                                                                                                                                                                                                                                                                                                                                                                                      |   |     |   | 10-Q                                |   | 9/30/2009 |   | 10.5 |   | 11/13/2009 |
|          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   |     |   |                                |   |   |   |   |   |   |
| 10.29         |   | Lease Agreement by and between WaferGen, Inc. and LBA Realty Fund III-Company VII, LLC dated October 22, 2009                                                                                                                                                                                                                                                                                                                                                                     |   |     |   | 10-Q                                |   | 9/30/2009 |   | 10.6 |   | 11/13/2009 |
|          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   |     |   |                                |   |   |   |   |   |   |
| 10.30 † |   | WaferGen Bio-Systems, Inc. 2008 Stock Incentive Plan, as amended                                                                                                                                                                                                                                                                                                                                                                                                                       |   |     |   | 8-K                                 |   |   |   | 10.1 |   | 12/10/2009 |
|          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   |     |   |                                |   |   |   |   |   |   |
| 10.31         |   | Form of Subscription Agreement between WaferGen Bio-systems, Inc., and the investors party thereto in connection with the Company’s December 2009 and January 2010 private placement offering of units of securities                                                                                                                                                                                                                                                   |   |     |   | S-1                                 |   |   |   | 10.58 |   | 3/2/2010 |
|          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   |     |   |                                |   |   |   |   |   |   |
| 10.32         |   | Form of Warrants to purchase shares of Common Stock of the Company, issued December 23, 2009, to investors in the Company’s December 2009 and January 2010 private placement offering of units of securities                                                                                                                                                                                                                                                      |   |     |   | S-1                                 |   |   |   | 10.59 |   | 3/2/2010 |
|          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   |     |   |                                |   |   |   |   |   |   |
| 10.33         |   | Registration Rights Agreement, dated December 23, 2009, between WaferGen Bio-systems, Inc., and the investors party thereto in connection with the Company’s December 2009 and January 2010 private placement offering of units of securities                                                                                                                                                                                                                     |   |     |   | S-1                                 |   |   |   | 10.60 |   | 3/2/2010 |
|          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   |     |   |                                |   |   |   |   |   |   |
| 21.1          |   | Subsidiaries of the Registrant                                                                                                                                                                                                                                                                                                                                                                                                                                                         |   |     |   | 10-K                                |   | 12/31/2008 |   | 21.1 |   | 3/27/2009 |
|          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   |     |   |                                |   |   |   |   |   |   |
| 23.1          |   | Letter of Consent from Independent Registered Public Accounting Firm, Rowbotham & Company LLP                                                                                                                                                                                                                                                                                                                                                                                      |   |     |   | 10-K                                |   | 12/31/2009 |   | 23.1 |   | 3/22/2010 |
|          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   |     |   |                                |   |   |   |   |   |   |
| 31.1          |   | Rule 13a-14(a)/15d-14(a) Certification of principal executive officer                                                                                                                                                                                                                                                                                                                                                                                                                  |   |     |   | 10-K                                |   | 12/31/2009 |   | 31.1 |   | 3/22/2010 |
|          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   |     |   |                                |   |   |   |   |   |   |
| 31.2          |   | Rule 13a-14(a)/15d-14(a) Certification of principal financial officer                                                                                                                                                                                                                                                                                                                                                                                                                  |   |     |   | 10-K                                |   | 12/31/2009 |   | 31.2 |   | 3/22/2010 |
|          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   |     |   |                                |   |   |   |   |   |   |
| 31.3          |   | Rule 13a-14(a)/15d-14(a) Certification of principal executive officer                                                                                                                                                                                                                                                                                                                                                                                                                  |   | X        |   |                                |   |   |   |   |   |   |
|          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   |     |   |                                |   |   |   |   |   |   |
| 31.4          |   | Rule 13a-14(a)/15d-14(a) Certification of principal financial officer                                                                                                                                                                                                                                                                                                                                                                                                                  |   | X        |   |                                |   |   |   |   |   |   |
|          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   |     |   |                                |   |   |   |   |   |   |
| 32.1          |   | Section 1350 Certification of principal executive officer  (This certification is being furnished and shall not be deemed “filed” with the SEC for purposes of Section 18 of the Exchange Act, or otherwise subject to the liability of that section, and shall not be deemed to be incorporated by reference into any filing under the Securities Act or the Exchange Act, except to the extent that the Registrant specifically incorporates it by reference.) |   |     |   | 10-K                                |   | 12/31/2009 |   | 32.1 |   | 3/22/2010 |
|          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   |     |   |                                |   |   |   |   |   |   |
| 32.2          |   | Section 1350 Certification of principal financial officer  (This certification is being furnished and shall not be deemed “filed” with the SEC for purposes of Section 18 of the Exchange Act, or otherwise subject to the liability of that section, and shall not be deemed to be incorporated by reference into any filing under the Securities Act or the Exchange Act, except to the extent that the Registrant specifically incorporates it by reference.) |   |     |   | 10-K                                |   | 12/31/2009 |   | 32.2 |   | 3/22/2010 |

| † |   | Indicates a management contract or compensatory plan or arrangement. |
|---------|--------|----------------------------------------------------------------------|

----

|                      |   | WAFERGEN BIO-SYSTEMS, INC.       |   |
|---------------------------|--------|-------------------------------------------------|--------|
|                      | By:    | /s/  Alnoor Shivji                    |   |
| Date: April 30, 2010 |   | Alnoor Shivji                                   |   |
|                      |   | Chairman, President and Chief Executive Officer |   |

| SIGNATURE                                      |   |  TITLE                                                                   |   |  DATE          |
|------------------------------------------------|--------|-------------------------------------------------------------------------------|--------|---------------------|
|    /s/  Alnoor Shivji |   |                                                                          |   |                |
| Alnoor Shivji                   |   | Chairman, President and Chief Executive Officer (principal executive officer) |   | April 30, 2010 |
| /s/  Hector Brush                    |   |                                                                          |   |                |
| Hector Brush                    |   | Treasurer (principal financial officer)                                       |   | April 30, 2010 |
|                                           |   |                                                                          |   |                |
| Dr. R. Dean Hautamaki           |   | Director                                                                      |   |                |
| /s/  Joel Kanter                     |   |                                                                          |   |                |
| Joel Kanter                     |   | Director                                                                      |   | April 30, 2010 |
| /s/  Makoto Kaneshiro                |   |                                                                          |   |                |
| Makoto Kaneshiro                     |   | Director                                                                      |   | April 30, 2010 |
| /s/  Nadine Smith                    |   |                                                                          |   |                |
| Nadine Smith                                   |   | Director                                                                      |   | April 30, 2010 |

|                           |   |     |   |                |
|--------------------------------|--------|----------|--------|---------------------|
| Dr. Robert Hariri              |   | Director |   |                |
|                           |   |     |   |                |
|                           |   |     |   |                |
| /s/  Robert Coradini |   |     |   |                |
| Robert Coradini                |   | Director |   | April 30, 2010 |
|                           |   |     |   |                |

----

| Exhibit No. | Description                                                                 |
|-------------|-----------------------------------------------------------------------------|
|        |                                                                        |
| 31.3   | Rule 13a-14(a)/15d-14(a) Certification of principal executive officer  |
| 31.4   | Rule 13a-14(a)/15d-14(a) Certification of principal financial officer  |

----

| 1. | I have reviewed this annual report on Form 10-K/A of WaferGen Bio-systems, Inc.; |
|----|---------------------------------------------------------------------------------------|

| 2. | Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report; |
|----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| Date: April 30, 2010 |                          |   |
|---------------------------|-------------------------------|--------|
|                      |                          |   |
|                      | /s/ Alnoor Shivji             |   |
|                      | Alnoor Shivji                 |
|                      | Chief Executive Officer       |
|                      | (principal executive officer) |

----

| 1. | I have reviewed this annual report on Form 10-K/A of WaferGen Bio-systems, Inc.; |
|----|---------------------------------------------------------------------------------------|

| 2. | Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report; |
|----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| Date: April 30, 2010 |                          |   |
|---------------------------|-------------------------------|--------|
|                      |                          |   |
|                      | /s/ Hector Brush              |   |
|                      | Hector Brush                  |
|                      | Treasurer                     |
|                      | (principal financial officer) |

----