Draft for Comment Version – March 1, 2014

Appendix C: Data Entry Sheets for the 

Registration Review Chemical Volatilization 

Screening Analysis 

Office of Pesticide Programs

Office of Chemical Safety and Pollution Prevention

U.S. Environmental Protection Agency

Washington, DC

March 1, 2014
Draft for Comment Version – March 1, 2014

2

Chemical 2,4-D

Reason for not 

performing screen

Have flux data and inhalation study available. No screen performed at this time.

Woodrow Worksheet:

VP- acid 1.9x10-5 Pa

SOL- acid 39208 mg/L

Koc- acid 20-136 mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 28-day inhalation – Sprague-Dawley rats

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol Residential (24 hr) HEC = 0.013 mg/L (13000 μg/m3)

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6 hrs/ day, 5 days/week

Uncertainty Factors 300

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

3

Chemical 2,4-DB

Reason for not 

performing screen

Woodrow Worksheet:

VP- acid 9.3x10-5 Pa

SOL- acid mg/L

Koc- acid mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Rat developmental toxicity

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 31 mg/kg/day; LOAEL = 62.5 mg/kg/day based on 

decreased maternal body weight, body weight gain, and food 

consumption, and clinical signs (emaciation, few feces)

converted to IEC (μg/m3) 118774

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 2.28E-02

Application timing Spring

Averaging time for Concentration 6 0.86

HEC or IEC (μg/m3) 118774

UF (unitless) 1000

Concentration of Concern (μg/m3) 119

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

4

Chemical 2,4-DP (Dichlorprop)

Reason for not 

performing screen

No food/feed uses (golf course, rights-of-way uses). No screen performed at this time.

Woodrow Worksheet:

VP- acid Pa

SOL- acid mg/L

Koc- acid mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

5

Chemical 2-EEEBC

Reason for not 

performing screen

Tree injection on ornamental trees formulated as an enclosed compressible capsule

Woodrow Worksheet:

VP N/A Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Duration of maximum emission (hours)

Maximum percent emitted in duration (%)

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

6

Chemical 4-Aminopyridine

Reason for not 

performing screen

Granular bait. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

7

Chemical Abamectin

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 2.0 x 10-7 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Combined data from three reproduction studies and two 

developmental neurotoxicity studies- Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) NOAEL = 0.12; LOAEL = 0.2 mg/kg/day based on decreased pup body 

weight. 

converted to IEC (μg/m3) 460

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 1.42E-04 1.42E-04 1.42E-04

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 460 460 460

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 0.46 0.46 0.46

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

8

Chemical Acephate

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 2.27E10-4 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 4 week inhalation (nose only) – Fischer 344 rats

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol NOAEL =1060 ug/m3 (0.00106 mg/L); LOAEL = 3123 ug/m3 

(0.003123 mg/L) based on brain ChE Inhibition.

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 4.76E-02 4.76E-02 4.76E-02

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 1060 1060 1060

UF (unitless) 100 100 100

Concentration of Concern (μg/m3) 10.60 10.60 10.60

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 247 674 1,117 1,504 N/A

Row crop 0 135 429 764 1,068 1,616

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

9

Chemical Acequinocyl

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.7 × 10-9 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Developmental Toxicity Study - Rabbits

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 60 mg/kg/day based on clinical signs (hematuria, reduced fecal 

output, body weight loss, and reduced food consumption) and gross 

necropsy findings (pale lungs and liver, hemorrhaging uterus, fluid in 

the cecum, fur in the stomach, blood stained vaginal opening, bloodstained urinary bladder contents/urine) at 120 mg/kg/day

converted to IEC (μg/m3) 440000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 2.75E-06 2.75E-06

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 440000 440000

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 440 440

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

10

Chemical Acetaminophen

Reason for not 

performing screen

One use to kill snakes via stuffed parachuted mice in Guam. No screen performed at this 

time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

11

Chemical Acetic acids, and salts (Vinegar)

Reason for not 

performing screen

Scoping document indicated a quantitative assessment not likely, no data called in, 

qualitative or existing assessments adequate...no screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC 

(μg/m3

)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

12

Chemical Acetochlor

Reason for not 

performing screen

Woodrow Worksheet:

VP 6.0x10-3 Pa

SOL 223 mg/L

Koc 314 mL/g

AR 3 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental toxicity in the rat – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 150 mg/kg/day, LOAEL = 600 mg/kg/day based on

increased fetal early resorptions and postimplantation loss, reduced 

mean fetal weight.

converted to IEC (μg/m3) 574713

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 1.30E+00 7.13E-01 7.13E-01

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 574713 574713 574713

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 575 575 575

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 440 N/A

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

13

Chemical Acibenzolar Methyl

Reason for not 

performing screen

Woodrow Worksheet:

VP 0.00048 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) Developmental Neurotoxicity Toxicity – Rat (Sprague-Dawley)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor NA

Aerosol NA

Inhalation study

(HEC calculated) (μg/m3

)

Vapor NA

Aerosol NA

Oral study (mg/kg/day) Developmental LOAEL = 82 mg/kg/day based on changes in brain 

morphometrics in the cerebellum in offspring. NOAEL= 8.2 

mg/kg/day

converted to IEC (μg/m3) 31,418 μg/m3

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

NO Cole NO EUP

Average Hourly Flux Rate (μg/m2-s) 8.84E-02 8.84E-02

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 31418 31418

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 31 31

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 289 456 N/A

Row crop

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

14

Chemical Acrolein

Reason for not 

performing screen

Aquatic herbicide. No screen performed at this time. Note: acrolein is known to volatilize 

from treated water and multiple air monitoring studies are available.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

15

Chemical Alachlor

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.2x10-3 Pa

SOL 242 mg/L

Koc 530 mL/g

AR 4 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Oral developmental toxicity in the rat – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 150 mg/kg/day; LOAEL (maternal) = 400 mg/kg/day, based on 

clinical signs of toxicity, mortality, decreased body weight gain; LOAEL 

(developmental) = 400 mg/kg/day, based on increased early/late 

resorptions, decreased viable fetuses.

converted to IEC (μg/m3) 574713

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 4.12E-01

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 574713

UF (unitless) 1000

Concentration of Concern (μg/m3) 575

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

16

Chemical Aldicarb

Reason for not 

performing screen

All uses have been cancelled. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

17

Chemical Aldoxycarb

Reason for not 

performing screen

All uses have been cancelled. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

18

Chemical Aliette (fosetyl-al)

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.3E-05 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 3-generation reproductive toxicity study (Sprague Dawley CFY) 

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 300 mg/kg/day; LOAEL = 600 mg/kg/day based on 

decreased litter and pup body weight (day 8) in both matings of each 

generation, F1 and F2.

converted to IEC (μg/m3) 1149425

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 4.47E-03 4.47E-03 4.47E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 1149425 1149425 1149425

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 1149.43 1149.43 1149.43

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

19

Chemical Aliphatic alcohols, C6-C16

Reason for not 

performing screen

Based on the lack of food and residential uses and low hazard via the oral, dermal, and 

inhalation routes of exposure, quantitative exposure assessments have not been 

conducted. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

20

Chemical Aliphatic esters

Reason for not 

performing screen

Based on the lack of hazard concern and the metabolic profile of the methyl esters of fatty 

acids, toxicological endpoints have not been identified for risk assessment purposes. 

Therefore, quantitative assessments have not been conducted. No screen performed at 

this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

21

Chemical Aliphatic solvents

Reason for not 

performing screen

Based on the lack of hazard concern for the aliphatic alcohols and esters, no screen 

performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

22

Chemical Allethrin stereoisomers

Reason for not 

performing screen

Allethrins have no agricultural uses (indoor, mosquito uses). No screen performed at this 

time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

23

Chemical alpha-Chlorohydrin

Reason for not 

performing screen

Rodenticide bait product in poly-paper sachets, which are then placed in tamper-proof bait 

boxes. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

24

Chemical Aluminum phosphide

Reason for not 

performing screen

Commodity Fumigant....No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

25

Chemical Ametoctradin

Reason for not 

performing screen

No hazard or points of departure selected

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

26

Chemical Ametryn

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.7 × 10-4 Pa

SOL 200 mg/L

Koc 390 mL/g

AR 2.4 Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) Rabbit Developmental Study

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 10 mg/kg/day based on body weight and deceased feed 

consumption and increased liver weight at 60 mg/kg/day.

converted to IEC (μg/m3) 73000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 8.66E-02

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 73000

UF (unitless) 1000

Concentration of Concern (μg/m3) 73

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

27

Chemical Amicarbazone

Reason for not 

performing screen

Woodrow Worksheet:

VP 4x10-4 Pa

SOL 4600 mg/L

Koc 23 mL/g

AR 0.448 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Subchronic dog study

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL was 6.28 mg/kg/day; LOAEL = 24.99 mg/kg/day based on 

increased thyroid vacuolization and decreased food consumption 

and glucose in females; increased platelets, phosphate, bile acids, 

absolute and relative liver weights, and lymphoid hyperplasia of the 

gall baldder in males; and decreased albumin and increased 

triglyercides, N-demethylase, and O-demethylase in both sexes

converted to IEC (μg/m3) 32106

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

28

Chemical Aminocyclopyrachlor

Reason for not 

performing screen

No agricultural uses (except rangeland). No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

29

Chemical Amitraz

Reason for not 

performing screen

Livestock (dip, ear tag) and pet use only. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

30

Chemical Amitrole

Reason for not 

performing screen

No agricultural uses (industrial areas, right-of-way uses). No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

31

Chemical Ancymidol

Reason for not 

performing screen

No agricultural uses (greenhouse uses). No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

32

Chemical Antimycin A

Reason for not 

performing screen

Used as a piscicida. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

33

Chemical Aquashade

Reason for not 

performing screen

Used as an aquatic algaecide/herbicide. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

34

Chemical Atrazine

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.71x10-5 Pa

SOL 33 mg/L

Koc 100 mL/g

AR 4 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Pubertal assay in rats - Wistar

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 6.25 mg/kg/day; LOAEL = 12.5 mg/kg/day based on 

delayed preputial separation in male offspring after 30 days of dosing

converted to IEC (μg/m3) 23046

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 2.85E-01 1.06E-02

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 23046 23046

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 23 23.05

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 2,010 3,625 > 4500 > 4500 > 4500 N/A

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

35

Chemical Azinphos-methyl

Reason for not 

performing screen

Voluntarily cancelled during Registration Review.

Woodrow Worksheet:

VP 5.1E-02 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90 day inhalation study – rats (Wistar)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol NOAEL = 1200 ug/m3 (0.0012 mg/L); LOAEL = 4700 ug/m3 (0.0047 

mg/l) based on inhibition of plasma and erythrocyte cholinesterase

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

36

Chemical Azoxystrobin (PC 128810)

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 1.1 x 10-10 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Prenatal Developmental Oral Toxicity – Alpk:AP (Wistar-derived) Rat 

(MRID 43678142)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) NOAEL = 25; LOAEL = 100 mg/kg/day based on increased maternal 

diarrhea, urinary incontinence, and salivation. (D402285, D402289)

converted to IEC (μg/m3) 92813

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 2.86E-07 2.86E-07 2.86E-07

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 92813 92813 92813

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 93 93 93

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

37

Chemical Benfluralin

Reason for not 

performing screen

Woodrow Worksheet:

VP .000871 Pa

SOL N/A mg/L

Koc N/A mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Rabbit Developmental

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) 100

converted to IEC (μg/m3) 730994

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X (lettuce) X(fruit trees)

Average Hourly Flux Rate (μg/m2-s) 0.145 0.145

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 730994 730994

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 731 731

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

38

Chemical Bensulfuron-Methyl (herbicide)

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 2.8×10-12 Pa at 25°C

SOL 2.9

12

120

mg/L at pH 4.8 at 25°C

mg/L at pH 5.8 at 25°C

mg/L at pH 6.9 at 25°C

Koc 282 

4.1 

mL/g at pH 1.5

mL/g at pH 7.0

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Chronic toxicity study in dogs (Note no inhalation POD selected 

previously but this is the lowest oral NOAEL)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL =19.9 mg/kg/day; LOAEL = 222.6 mg/kg/day based on

discoloration and inflammation of oral mucosa; increased liver 

weight in the presence of increased AP and ALT and microscopic 

lesions.

converted to IEC (μg/m3) 101738

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 1.38E-08

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 101738

UF (unitless) 1000

Concentration of Concern (μg/m3) 102

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

39

Chemical Bensulide (PC Code: 009801)

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 1.x10-4 Pa

SOL 25 mg/L

Koc 16,000 mL/g

AR 6.0 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 21 day - Developmental Rat (Sprague-Dawley)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) Short-term POD= 5.5 mg/kg/day based on maternal plasma 

cholinesterase (ChE) inhibition (21 days of treatment, the earliest 

ChE examination period), in the rat developmental study.

converted to IEC (μg/m3) 21073

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 1.49E-02 2.42E-02 2.42E-02

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 1200 1200 1200

UF (unitless) 100 100 100

Concentration of Concern (μg/m3) 12.00 12.00 12.00

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 73

Orchard
Draft for Comment Version – March 1, 2014

40

Chemical Bentazon

Reason for not 

performing screen

Woodrow Worksheet:

VP 5.4 x 10-8 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Prenatal developmental toxicity – rat (Wistar)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 100 mg/kg/day , Increased postimplantation loss, skeletal variations, and 

reduced weight of fetuses at 250 mg/kg/day

converted to IEC (μg/m3) 370000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (FQPA)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 4.80E-05 4.80E-05 4.80E-05

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 370000 370000 370000

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 370 370 370

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

41

Chemical Benthiavalicarb-isopropyl

Reason for not 

performing screen

Import uses only. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

42

Chemical Benzoic Acid

Reason for not 

performing screen

No registered conventional pesticide uses. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

43

Chemical Benzyl benzoate

Reason for not 

performing screen

No agricultural uses (indoor, pet uses). No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

44

Chemical Bifenazate

Reason for not 

performing screen

Woodrow Worksheet:

VP 9.9 x 10-6 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) 28 Day Inhalation Study - Rat 

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol 30000 ug/m3 based on dried red material around the nose in 

females, lower body weights and weight gains, decreased food 

consumption, decreased heart and thymus weights in females, 

increased incidences of mild brown pigmentation of the spleen, and 

minimal to mild degeneration of the olfactory epithelium within 

nasal levels III, IV, and V in both sexes at 75000 ug/m3

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 3.57E-03 3.57E-03 3.57E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 30000 30000 30000

UF (unitless) 100 100 100

Concentration of Concern (μg/m3) 300 300 300

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

45

Chemical Bifenthrin

Reason for not 

performing screen

Woodrow Worksheet:

VP 0.000024 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Wolansky Acute Oral Rat (Long Evans) – BMD Analysis Conducted

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) BMD = 3.1 mg/kg/day; BMD1SD = 4.1 mg/kg/day based on reductions 

in locomotor activity; 

converted to IEC (μg/m3) 11312

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 7.43E-03 7.43E-03 7.43E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 11312 11312 11312

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 11.31 11.31 11.31

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

46

Chemical Bispyribac-sodium

Reason for not 

performing screen

Woodrow Worksheet:

VP 5.1 × 10-9 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Developmental Toxicity Study - Rabbit

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 100 mg/kg/day based on lethargy, diarrhea and decreased body-weight 

gain in the range-finding study at 300 mg/kg/day

converted to IEC (μg/m3) 730000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 6.83E-06

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 730000

UF (unitless) 1000

Concentration of Concern (μg/m3) 730

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

47

Chemical Bitrex

Reason for not 

performing screen

EPA is not opening a docket for Bitrex because this pesticide is not included in any products 

actively registered under FIFRA section 3. The Agency will take separate action to cancel any 

remaining FIFRA section 24(c) Special Local Needs registrations with this active ingredient 

and to propose revocation of any affected tolerances that are not supported for import 

purposes only. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

48

Chemical Boscalid (PC 128008)

Reason for not 

performing screen

Woodrow Worksheet:

VP 7.2 X 10-7 at 

20o C

Pa

SOL 4.6 at 20oC mg/L

Koc 970 mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Chronic Toxicity – Wistar Rat (MRID 45404827)

Carcinogenicity – Wistar Rat (MRID 45404828)

Chronic Toxicity – Dog (MRID 45404826) 

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) NOAEL = 21.8 mg/kg/day ; LOAEL = 57 mg/kg/day, based on liver and 

thyroid effects. (D363305)

converted to IEC (μg/m3) 111452 (used dog)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 4.09E-04 4.09E-04 4.09E-04

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 111452 111452 111452

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 111 111 111

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

49

Chemical Brodifacoum

Reason for not 

performing screen

Rodenticide bait. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

50

Chemical Bromacil

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.3x10-5 Pa

SOL 899.2 mg/L

Koc 32 mL/g

AR 6.4 Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) Developmental Toxicity – Rats (Sprague Dawley)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 20 mg/kg bw/day based on deficits in body-weight gain and food 

consumption during the first 2 days of dosing at 75 mg/kg bw/day.

converted to IEC (μg/m3) 77000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 2.63E-02

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 77000

UF (unitless) 1000

Concentration of Concern (μg/m3) 77

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

51

Chemical Bromadiolone

Reason for not 

performing screen

Rodenticide bait. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

52

Chemical Bromethalin

Reason for not 

performing screen

Rodenticide bait. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

53

Chemical Bromoxynil and its Esters (PC 035301, 035302, 128920)

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.9 X 10-4 Pa

SOL N/A mg/L

Koc N/A mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental Toxicity Oral – Sprague Dawley Rat (MRID 

40466802, 00116558)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) NOAEL= 4 mg/kg/day; LOAEL of 5 mg/kg/day based on increased 

incidence of supernumerary ribs (D374609)

converted to IEC (μg/m3) 15326

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 4.11E-02 4.11E-02

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 15326 15326

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 15 15

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 225 389 N/A

Row crop 0 0 0 96 205 393

Orchard
Draft for Comment Version – March 1, 2014

54

Chemical Bromuconazole (120503)

Reason for not 

performing screen

No agricultural uses; only use is on roses. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

55

Chemical Buprofezin

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.68 x 10-2 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90 Day Oral Toxicity Study - Rat (Sprague Dawley)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 13.0 mg/kg/day; LOAEL = 68.6 mg/kg/day based on organ 

weight changes and microscopic finding in liver, thyroid and kidney

converted to IEC (μg/m3) 49808

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 1.67E+00 1.67E+00

Application timing Spring Spring

Averaging time for Concentration 6 0.86 6

HEC or IEC (μg/m3) 49808 49808

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 50 50

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 4,471 > 4500 > 4500 > 4500 > 4500 N/A

Row crop

Orchard 313 620 1,138 1,596 2,020 N/A
Draft for Comment Version – March 1, 2014

56

Chemical Butoxypolypropylene Glycol

Reason for not 

performing screen

No agricultural uses (livestock insect repellent). No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

57

Chemical Butralin (PC 106501)

Reason for not 

performing screen

Woodrow Worksheet:

VP 0.000772 Pa

SOL N/A mg/L

Koc N/A mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90-day Inhalation – Fischer 344 Rat (MRID 42633601)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol NOEL = 300000 ug/m3; LOEL = 1000000 ug/m3 based on 

histopathological effects in nasal passages (D226078)

Inhalation study

(HEC calculated)

(μg/m3)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) N/A 

converted to IEC (μg/m3) N/A

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 1.31E-01

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 300000

UF (unitless) 100

Concentration of Concern (μg/m3) 3000

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

58

Chemical Butylate – Soil Incorporated Herbicide

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.7 Pa Pa

SOL 45 mg/L

Koc 400 mL/g

AR 6.2 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Rat Developmental study - Sprague-Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 40 mg/kg/day; LOAEL = 400 mg/kg/day based on 

decreased fetal weights and increased incidences of misaligned 

sternebrae

converted to IEC (μg/m3) 153257

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X 

Average Hourly Flux Rate (μg/m2-s) 1.07E+03

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 153257

UF (unitless) 1000

Concentration of Concern (μg/m3) 153.26

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

59

Chemical Cacodylic acid, and salts

Reason for not 

performing screen

All uses cancelled. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

60

Chemical Captan

Reason for not 

performing screen

NA

Woodrow Worksheet:

VP <0.0013 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) 90-day inhalation study, Wistar rats, (nose only) to Captan 

(88.7%)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor NA

Aerosol No systemic toxicity was seen at the highest dose tested. 

Therefore, the NOAEL/LOAEL were greater than 12.98 μg/L, the 

highest dose tested (HDT). Local irritation was observed at all 

doses tested. The local irritation LOAEL was equal to or less than 

0.13 μg/L (LDT and 130 μg/m3), based on squamous hyperplasia 

in the larynx of females. Irritation NOAEL not established (MRID 

41234402).

Inhalation study

(HEC calculated) (μg/m3)

Vapor NA

Aerosol NA

Oral study (mg/kg/day) NA

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000x since no NOAEL

Representative Crops

Bare Ground Cole/Cotton Row Orchard

N/A Y Y Y

Average Hourly Flux Rate (μg/m2-s) 2.01E-01 2.01E-01 2.01E-01

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 130 130 130

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 0.13 0.13 0.13

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Row crop > 4500 > 4500 > 4500 > 4500 > 4500 > 4500

Orchard > 4500 > 4500 > 4500 > 4500 > 4500 N/A
Draft for Comment Version – March 1, 2014

61

Chemical Carbaryl

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 1.56E-04 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Comparative Cholinesterase Study- (Long-Evans hooded rats)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) BMDL10 - 1.1 mg/kg/da; BMD = 1.5 mg/kg/day based on brain ChE 

inhibition in post-natal day 11 [males only]

converted to IEC (μg/m3) 4148

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100 (have inhalation study and dose is similar to oral study so no 

extra 10X for screen)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 3.49E-02 3.49E-02 3.49E-02

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 4148 4148 4148

UF (unitless) 100 100 100

Concentration of Concern (μg/m3) 41.48 41.48 41.48

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

62

Chemical Carbofuran

Reason for not 

performing screen

All uses have been cancelled. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

63

Chemical Carbon and CO2

Reason for not 

performing screen

No agricultural uses. Used for fumigation (gaseous products are generated by oxidation of 

carbonaceous materials within flare like containers to form carbon dioxide) of coyotes, red 

foxes, striped skunks, woodchucks, yellow-bellied marmots, ground squirrels, prairie dogs, 

moles, gophers, rats. Use sites include lawns, parks, golf courses, rangeland, reforested 

areas, open fields, meadows, and non-crop areas.

Woodrow Worksheet:

VP N/A Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

64

Chemical Carfentrazone-ethyl

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.6 x 10-5 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Subchronic Neurotoxicity-Rat (Sprague Dawley)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 50 mg/kg/day based on decreased body-weight gain increased 

urinary excretion of porphyrins at 150 mg/kg/day.

converted to IEC (μg/m3) 190000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 5.31E-03 5.31E-03 5.31E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 190000 190000 190000

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 19 19 19

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

65

Chemical Chlorantraniliprole

Reason for not 

performing screen

Based on the lack of hazard identified in the acute inhalation study, lack of acute irritation, 

and extremely low oral toxicity, no inhalation endpoint was selected for quantitative risk 

assessment. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

66

Chemical Chlorethoxyfos

Reason for not 

performing screen

Woodrow Worksheet:

VP 0.23 Pa

SOL N/A mg/L

Koc N/A mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) 7- day rat inhalation 

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol 0.000508 mg/l

Inhalation study

(HEC calculated) (μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day)

converted to IEC (μg/m3) N/A

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X(corn)

Average Hourly Flux Rate (μg/m2-s) 14.5

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 508

UF (unitless) 100

Concentration of Concern (μg/m3) 5

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop > 4500 > 4500 > 4500 > 4500 > 4500 > 4500

Orchard
Draft for Comment Version – March 1, 2014

67

Chemical Chlorfenapyr

Reason for not 

performing screen

Chlorfenapyr has no outdoor agricultural uses. Current food uses include fruiting vegetable 

crop group 8 (limited to those grown in greenhouses).

Woodrow Worksheet:

VP 9.3 x 10-5 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) 90-Day Feeding Study - Dog 

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 3.9 mg/kg/day based on emaciation, decreased body-weight gains, and 

decreased food efficiency at 6.7/6.8 mg/kg/day, M/F.

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

68

Chemical Chlorflurenol

Reason for not 

performing screen

No agricultural uses (turf, ornamental uses). No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

69

Chemical Chlormequat Chloride

Reason for not 

performing screen

No outdoor or agricultural uses (plant growth regulator used in green houses)

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

70

Chemical Chloroneb

Reason for not 

performing screen

Seed treatment uses. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

71

Chemical Chlorophacinone

Reason for not 

performing screen

Rodenticide bait. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

72

Chemical Chloropicrin

Reason for not 

performing screen

Fumigant

Woodrow Worksheet:

VP N/A Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) N/A

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

73

Chemical Chlorothalonil

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 1.3 x 10-3 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Acute Rat Inhalation (Sprague-Dawley)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol HEC = 400 ug/m3 based on clinical signs consisting of hypoactivity, 

gasping, lacrimation, nasal discharge, piloerection, ptosis, and 

respiratory gurgle

Oral study (mg/kg/day) N/A

converted to IEC (μg/m3) N/A

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 30

Representative Crops

Bare Ground Cole/Cotton Row Orchard

N/A X X X

Average Hourly Flux Rate (μg/m2-s) 2.01E-01 2.01E-01 2.01E-01

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 400 400 400

UF (unitless) 30 30 30

Concentration of Concern (μg/m3) 13 13 13

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 1,746 3,126 > 4500 > 4500 > 4500 N/A

Row crop 1,265 2,327 4,110 > 4500 > 4500 > 4500

Orchard 0 98 322 503 671 N/A
Draft for Comment Version – March 1, 2014

74

Chemical Chlorpropham

Reason for not 

performing screen

Only “agricultural” use is Easter lilies which are only grown in Norther CA and Southern OR

Woodrow Worksheet:

VP 2.5 x 10-2 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Chronic Toxicity - Dog

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 5 mg/kg/day based on increased thyroid weight and 

histopathological changes in both sexes, statistically significant 

decreases in thyroxine (T4) levels seen at week 14 in males at 50 

mg/kg/day.

converted to IEC (μg/m3) 26000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 2.32

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 26000

UF (unitless) 1000

Concentration of Concern (μg/m3) 26

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Orchard
Draft for Comment Version – March 1, 2014

75

Chemical Chlorpyrifos

Reason for not 

performing screen

Woodrow Worksheet:

VP 0.0025 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Acute Inhalation Study (Crl:CD(SD))

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol NOAEL = 620 ug/m3; LOAEL = 3700 ug/m3 based on lung ChE 

inhibition.

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 300 (LOAEL to NOAEL)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 3.46E-01 3.46E-01 3.46E-01

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 620 620 620

UF (unitless) 300 300 300

Concentration of Concern (μg/m3) 2.07 2.07 2.07

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Row crop > 4500 > 4500 > 4500 > 4500 > 4500 > 4500

Orchard 1,790 3,055 > 4500 > 4500 > 4500 N/A
Draft for Comment Version – March 1, 2014

76

Chemical Chlorpyrifos Methyl

Reason for not 

performing screen

Grain/Cereal/Seed/Flour Bin and Warehouse Storage Treatment are the only uses. No 

screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

77

Chemical Chlorsulfuron

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.73 x 10-9 Pa

SOL 587 mg/L

Koc 33 mL/g

AR 0.058 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental toxicity study in rabbits

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 75 mg/kg/day; LOAEL=200 mg/kg/day based on decreased 

body weight gains.

converted to IEC (μg/m3) 548246

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 5.22E-07

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 548246

UF (unitless) 1000

Concentration of Concern (μg/m3) 548

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

78

Chemical Cholecalciferol

Reason for not 

performing screen

Rodenticide bait. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

79

Chemical Clethodim (PC 121011, Post-Emergent Herbicide)

Reason for not 

performing screen

Woodrow Worksheet:

VP <1 x10-5 Pa at 20oC

SOL 5,400 mg/L

Koc 0.005 -0.27 mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental Oral - Sprague Dawley Rat (MRID 41030116)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) NOAEL = 100 mg/kg/day; LOAEL = 350 mg/kg/day based on 

decreased body weight gain dose related increase in incidence of 

excessive salivation, lacrimation, anogenital staining and red nasal 

discharge. (D384944)

converted to IEC (μg/m3) 383142

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 3.60E-03 3.60E-03 3.60E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 383142 383142 383142

UF (unitless) 100 100 100

Concentration of Concern (μg/m3) 3831 3831 3831

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

80

Chemical Clodinafop-propargyl (PC code 125203)

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.19 x 10-6 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental Toxicity Study in Rats – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) NOAEL = 5 mg/kg/day; Increased incidence of bilateral distension and 

torsion of ureters, unilateral 14th ribs and incomplete ossification of 

metacarpals and cranial bones at 40 mg/kg/day.

converted to IEC (μg/m3) 19157

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 1.65E-03

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 19157

UF (unitless) 1000

Concentration of Concern (μg/m3) 19

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

81

Chemical Clofencet (128726)

Reason for not 

performing screen

No short or intermediate term inhalation endpoints were identified for this chemical.

Woodrow Worksheet:

VP 0.000013 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) No short-term inhalation endpoint identified

Use Chronic oral toxicity in the dog for screen

Inhalation study

(no HEC currently calculated) 

(μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) LOAEL = 200.0 mg/kg/day, based on testicular and epididymal pathology in 

males liver effects in females. NOAEL = 5.0 mg/kg/day

converted to IEC (μg/m3) 25562

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 4.47E-03

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 25562

UF (unitless) 1000

Concentration of Concern (μg/m3) 25.56

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

82

Chemical Clofentezine

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.3 X10-7 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 13 week rat study (Sprague-Dawley)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) 2

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Grapes X (fruit and 

nut trees)

Average Hourly Flux Rate (μg/m2-s) 9.93E-05 9.93E-05

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 7663 7663

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 8 8

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

83

Chemical Clomazone

Reason for not 

performing screen

NA

Woodrow Worksheet:

VP 0.019 Pa

SOL 1100 mg/L

Koc 274 mL/g

AR 1.25 Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) Developmental toxicity rat (Sprague Dawley) 

Inhalation study

(no HEC calculated) (μg/m3)

Vapor NA

Aerosol NA

Inhalation study

(HEC calculated) (μg/m3)

Vapor NA

Aerosol NA

Oral study (mg/kg/day) Maternal LOAEL = 300 mg/kg/day, based on chromorhinorrhea and 

abdominogenital staining. NOAEL 100 mg/kg/day

converted to IEC (μg/m3) 380000 μg/m3

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 4.65E-01

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 380000

UF (unitless) 1000

Concentration of Concern (μg/m3) 380

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

84

Chemical Clopyralid (117403)

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.33E-3 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Prenatal Developmental Rat (Fischer 344) – GD 6-15

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) 75 mg/kg/day

converted to IEC (μg/m3) 265957

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 2.01E-01 2.01E-01

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 265957 265957

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 265.96 265.96

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

85

Chemical Cloransulam

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.999E-14 Pa

SOL In water (25 deg C) = 16 mg/l (distilled), 3 mg/l 

(pH 5), 184 mg/l (pH 7), 3430 mg/l (pH 9)

mg/L

Koc 12-262 mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) An inhalation endpoint was not established. Chronic dietary 

endpoint (liver effects) based on Chronic dog. NOAEL = 10.

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X(soybean)

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

86

Chemical Clothianidin (044309)

Reason for not 

performing screen

NA

Woodrow Worksheet:

VP 1.3 x 10-10 Pa

SOL 327 mg/L (20°C)

Koc 188 mL/g

AR 0.21 Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 2-generation rat reproduction study (Sprague-Dawley)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 9.8 mg/kg/day; LOAEL = 31.2 mg/kg/day, based on 

decreased body weight gains, delayed sexual maturation, decreased 

absolute thymus weights in F1 pups, and increased stillbirths in both 

generations.

converted to IEC (μg/m3) 37548

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Yes Yes Yes Yes

Average Hourly Flux Rate (μg/m2-s) 3.17E-08 3.29E-07 3.29E-07 3.29E-07

Application timing Spring Spring Spring Spring

Averaging time for Concentration 6 6 6 6

HEC or IEC (μg/m3) 37548 37548 37548 37548

UF (unitless) 1000 1000 1000 1000

Concentration of Concern (μg/m3) 37.55 37.55 37.55 37.55

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

87

Chemical Coppers

Reason for not 

performing screen

No endpoints of toxicological concern have been identified for risk assessment purposes 

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

88

Chemical Coumaphos

Reason for not 

performing screen

No agricultural crop uses. Use on cattle and as a pest strip in beehives

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

89

Chemical Cryolite

Reason for not 

performing screen

No inhalation toxicity endpoint currently. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

90

Chemical Cyazofamid (PC code 125203)

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.33 x 10-5 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Rat Prenatal Developmental Toxicity (MRID 45408933) – Sprague 

Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) NOAEL = 100 mg/kg/day; LOAEL = 1,000 mg/kg based on 

developmental toxicity findings of increased incidence of bent ribs.

converted to IEC (μg/m3) 383142

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 4.56E-03 4.56E-03 4.56E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 383142 383142 383142

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 383 383 383

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

91

Chemical Cyclanilide

Reason for not 

performing screen

Woodrow Worksheet:

VP 8.4 x 10-6 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) Subchronic (13 week) oral toxicity based on increased motor activity 

and decreased body weight

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 4.0 mg/kg/day

converted to IEC (μg/m3) 15,326

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 3.12E-03 3.12E-03 3.12E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 15326 15326 15326

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 15.33 15.33 15.33

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

92

Chemical Cyflumetofen

Reason for not 

performing screen

Woodrow Worksheet:

VP 5.9e-6 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) Three co-critical studies: 90-day feeding study; Chronic toxicity study; 

Two generation reproduction study (oral)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3) NOAEL = 16.5 mg/kg/day

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 2.33E-03 2.33E-03

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 58511 58511

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 59 59

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

93

Chemical Cyfluthrins (128831)

Reason for not 

performing screen

NA

Woodrow Worksheet:

VP 7.2 x 10-9 Pa

SOL 0.0019-0.0029 mg/L (20°C)

Koc 124,000 mL/g

AR 0.027 Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 28-day rat inhalation study with beta-cyfluthrin (Wistar)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol NOAEL= 260 μg/m3; LOAEL = 2700 μg/m3, based on decreases in 

body weight in both sexes, and decreased urinary pH in males.

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Yes Yes Yes Yes

Average Hourly Flux Rate (μg/m2-s) 1.52E-05 9.08E-06 9.08E-06 9.08E-06

Application timing Spring Spring Spring Spring

Averaging time for Concentration 6 6 6 6

HEC or IEC (μg/m3) 260 260 260 260

UF (unitless) 100 100 100 100

Concentration of Concern (μg/m3) 2.60 2.60 2.60 2.60

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

94

Chemical Cyhalofop-butyl (082583)

Reason for not 

performing screen

NA

Woodrow Worksheet:

VP 5.3 x 10-5 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90-day mouse oral study (ICR)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 4.3 mg/kg/day; LOAEL = 14.1 mg/kg/day, based on 

enlarged kidneys in females with swelling of proximal tubular cells in 

4 of 12 mice.

converted to IEC (μg/m3) 10297 (used CF for B6C3F1 mice)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

No X No No

Average Hourly Flux Rate (μg/m2-s) 1.43E-02

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 10297

UF (unitless) 1000

Concentration of Concern (μg/m3) 10.30

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

95

Chemical Cyhexatin

Reason for not 

performing screen

Currently No Registrations, No scoping document done... No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC 

(μg/m3

)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

96

Chemical Cymoxanil

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 1.5 x 10-4 Pa (20°C)

SOL 780 mg/L

Koc 110 mL/g

AR 0.16 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental toxicity (rabbit)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 4 mg/kg/day; LOAEL = 8 mg/kg/day based on increased 

skeletal malformations of the cervical and thoracic vertebrae and 

ribs

converted to IEC (μg/m3) 29240

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 3.38E-02 3.38E-02

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 29240 29240

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 29.24 29.24

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

97

Chemical Cypermethrin (109702)

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.53E-7 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 21-day Inhalation Study (Wistar)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol NOAEL = 0.01 mg ai/L (2.7 mg/kg/day) = 10000 μg/m3

LOAEL = 0.05 mg/kg/day based on decreases in body weight and salivation.

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 300

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 1.72E-04 1.72E-04 1.72E-04

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 10000 10000 10000

UF (unitless) 300 300 300

Concentration of Concern (μg/m3) 33.33 33.33 33.33

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

98

Chemical Cyphenothrin (129013)

Reason for not 

performing screen

Current uses are only indoor premise treatments or direct applications to pets. No 

agricultural uses registered. No screen performed at this time

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

99

Chemical Cyproconazole

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.6 x 10-5 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Prenatal Developmental toxicity Study – New Zealand white rabbits

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 2mg/kg/day; LOAEL = 10 mg/kg/day based on increased incidence 

of malformed fetuses and litters with malformed fetuses.

converted to IEC (μg/m3) 14620

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 7.93E-03 7.93E-03

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 14260 14260

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 14 14

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

100

Chemical Cyprodinil

Reason for not 

performing screen

NA

Woodrow Worksheet:

VP 0.00051 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) 28-Day Feeding/Range-Finding – Rat (Tif:RAIf(SPF)) Sprague dawley 

derived albino rats.

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor NA

Aerosol NA

Inhalation study

(HEC calculated) (μg/m3

)

Vapor NA

Aerosol NA

Oral study (mg/kg/day) LOAEL = 299 mg/kg/day based on decreased body-weight gain, 

increased cholesterol and phospholipid levels, microcytosis, and 

hepatocyte hypertrophy. NOAEL 62 MKD

converted to IEC (μg/m3) 237,548 μg/m3

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

NO Cole NO Pome/Stone

Average Hourly Flux Rate (μg/m2-s) 9.29E-02 9.29E-02

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 237548 237548

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 238 238

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

101

Chemical Cyromazine

Reason for not 

performing screen

NA

Woodrow Worksheet:

VP 0.0000004 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) 28- day rat inhalation (Albino Rats {(Tif: RAIF (SPF), hybrids of RII/1 x 

RII/2strain}, Rats were exposed via nose only 4 hours/day, 7 days per week 

for a total of 28 exposures, MRID: 47940804

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol Endpoint of toxicity is a LOAEL 55000 ug/m3 based on impairment of the 

general condition with the symptoms of piloerection, dyspnea, hunched 

posture, and reduced spontaneous activity. The NOAEL was not observed. 

Uncertainty Factor (UF): 3000 – 10x for interspecies extrapolation, 10x for 

intraspecies variation, and 3x for extrapolation of the study LOAEL to 

NOAEL and 10x data base UF for the lack of neurotoxicity battery and 

immunotoxicity studies. 

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC 

(μg/m3

)

Duration of Animal Exposure per Day (hrs) 4

Uncertainty Factors 3000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 2.52E-04

Application timing Spring

Averaging time for Concentration 4

HEC or IEC (μg/m3) 55000

UF (unitless) 3000

Concentration of Concern (μg/m3) 18

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

102

Chemical Daminozide (Alar) (035101) 

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP Alar

2x 10-4 at 23 

±2 °C

UDMH

(metabolite)

22, 261

Pa

SOL N/A mg/L

Koc N/A mL/g

AR Kg/ha

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90 Day Rat (40032607)-DER unavailable-strain unknown

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 0.8 mg/kg/day

converted to IEC (μg/m3) Wistar (2950) Sprague Dawley (3065)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 4.29E-02

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 3065

UF (unitless) 1000

Concentration of Concern (μg/m3) 3.07

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 1,125 2,099 3,733 > 4500 > 4500 > 4500

Orchard
Draft for Comment Version – March 1, 2014

103

Chemical Dazomet

Reason for not 

performing screen

Fumigant

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

104

Chemical DCNA

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.6 x 10-4 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90-Day feeding - Dog

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 2 .5 mg/kg/day; LOAEL = 75 mg/kg/day based on changes in 

hematological (decreased hemoglobin and hematocrit at 4, 8, and 

14 weeks) and clinical biochemistry parameters, reduced body 

weight gain, increased liver, spleen and kidney weights, and 

histopathological changes in the liver 

converted to IEC (μg/m3) 12781

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 5.32E-02 5.32E-02 5.32E-02

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 12781 12781 12781

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 13 13 13

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 130 561 933 1,285 N/A

Row crop 0 81 351 617 892 1,383

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

105

Chemical DCPA

Reason for not 

performing screen

Woodrow Worksheet:

VP 0.00033 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Subchronic Oral Rat (Sprague Dawley)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 50mg/kg/day; LOAEL = 100 mg/kg/day based on increased 

incidence of hepatocellular hypertrophy

converted to IEC (μg/m3) 191571

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 6.49E-02

Application timing Spring

Averaging time for Concentration 6 0.86

HEC or IEC (μg/m3) 191751

UF (unitless) 1000

Concentration of Concern (μg/m3) 192

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

106

Chemical DDVP (dichlorvos)

Reason for not 

performing screen

No agricultural uses (indoor uses). No screen performed at this time.

Woodrow Worksheet:

VP 2.1 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) Acute residential: Acute CCA-Adult F brain – BMDL10 = 0.8 mg/kg (SD rat 135-191 g)

ST Residential: Human male 16-day study. LOAEL =0.1 mkd (RBC AChE)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) Acute: 0.8 mg/kg/day 

Short term: 0.1 mg/kg/day

converted to IEC (μg/m3) Acute: 824 μg/m3

Short term: 350 μg/m3 

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors Acute residential: 10x intrasp., 3x intersp for pharmdyn. = 30x

ST residential: 10x intrasp., 3x Lo->No = 30x

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

107

Chemical DEET

Reason for not 

performing screen

No agricultural uses. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

108

Chemical Deltamethrin (097805)

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 1.9995x10-6 Pa

SOL 0.0002 –

0.002

mg/L

Koc 7.05 x 105 to 

3.14 x 106

mL/g

AR Kg/ha

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Long Evans; special study (motor activity following a single dose –

motor activity assessed for 1 hour during peak effects)

Inhalation study

(no HEC currently calculated) 

(μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 1 mg/kg/day (Wolansky study)

converted to IEC (μg/m3) 3771

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 300

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 9.52E-04 9.52E-04 9.52E-04

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 3771 3771 3771

UF (unitless) 300 300 300

Concentration of Concern (μg/m3) 13 13 13

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

109

Chemical Denatonium Saccharide

Reason for not 

performing screen

Qualitative Reg Review Risk Assessment....No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

110

Chemical Desmedipham

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.99 x 10-7 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Rat Developmental (Wistar)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) 10

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X (Beets and 

spinach)

Average Hourly Flux Rate (μg/m2-s) 2.51E-04

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 36873

UF (unitless) 1000

Concentration of Concern (μg/m3) 37

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard

[NOTE from SMS: I think the crops are more like cole/cotton but the distance to COC is still “0”]
Draft for Comment Version – March 1, 2014

111

Chemical Diazinon

Reason for not 

performing screen

Woodrow Worksheet:

VP 8x10-3 Pa (20°C)

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 21-day Rat Inhalation

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol LOAEL=100 ug/m3 (0.026 mg/kg/day) based on Plasma and RBC 

cholinesterase inhibition

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study 4 (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 300 (LOAEL to NOAEL 3X)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 9.05E-01 9.05E-01 9.05E-01

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 100 100 100

UF (unitless) 300 300 300

Concentration of Concern (μg/m3) 0.33 0.33 0.33

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Row crop > 4500 > 4500 > 4500 > 4500 > 4500 > 4500

Orchard > 4500 > 4500 > 4500 > 4500 > 4500 N/A
Draft for Comment Version – March 1, 2014

112

Chemical Dicamba

Reason for not 

performing screen

Woodrow Worksheet:

VP 4.50 x 10-3 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Two Generation Reproductive Study (Sprague-Dawley)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 45 mg/kg/day; based on impaired pup growth (decreased pup 

weights) at LOAEL = 136 mg/kg/day.

converted to IEC (μg/m3) 172414

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 5.62E-01 5.62E-01

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 172414 172414

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 172 172

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 251 485 681 N/A

Row crop 0 0 123 285 424 754

Orchard
Draft for Comment Version – March 1, 2014

113

Chemical Dichlobenil

Reason for not 

performing screen

Woodrow Worksheet:

VP 0.073 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 28-Day Inhalation (Sprague Dawley)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol NOAEL= 12000 ug/m3

; 21000ug/m3 based on nasal degeneration.

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare 

Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 5.63E+00 5.63E+00

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 12000 12000

UF (unitless) 100 100

Concentration of Concern (μg/m3) 120 120

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop > 4500 > 4500 > 4500 > 4500 > 4500 > 4500

Orchard 506 930 1,650 2,285 2,871 N/A
Draft for Comment Version – March 1, 2014

114

Chemical Dicofol

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 4.0 x 10-7 Pa (20°C)

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental Rabbit Study

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 4 mg/kg/day; LOAEL = 40 mg/kg/day based on Increase in 

frequency of abortions

converted to IEC (μg/m3) 29240

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 2.52E-04 2.52E-04

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 29240 29240

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 29 29

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

115

Chemical Dicrotophos

Reason for not 

performing screen

NA

Woodrow Worksheet:

VP 0.013 Pa

SOL NA mg/L

Koc NA mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) A steady state inhalation PoD was selected from a 28-day inhalation 

toxicity study (MRID 48146702) in rats (Crl:CD (SD)) based on brain 

ChE inhibition (BMDL10 = 0.34 μg/L/day or 0.00034 mg/L/day; 

BMD10 = 0.4 μg/L/day or 0.0004 mg/L/day) in the female rat.

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor BMDL10 = 0.34 μg/L/day or 0.00034 mg/L/day or 340 μg/m3

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

No Yes No No

Average Hourly Flux Rate (μg/m2-s) 1.35

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 340

UF (unitless) 100

Concentration of Concern (μg/m3) 3

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

116

Chemical Difenacoum

Reason for not 

performing screen

Rodenticide bait. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

117

Chemical Difenoconazole

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.3 x 10-8 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Reproduction and fertility Study (rat; dietary) 

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL 1.25 mg/kg/day; LOAEL = 12.5 mg/kg/day based on decreased pup 

weight in males on day 21 and reduction in body-weight gain of F0 females 

prior to mating, gestation and lactation.

converted to IEC (μg/m3) 4789

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 3.20E-05 3.20E-05 3.20E-05

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 4789 4789 4789

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 5 5 5

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

118

Chemical Difenzoquat

Reason for not 

performing screen

Voluntarily cancelled...No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

119

Chemical Difethialone

Reason for not 

performing screen

Rodenticide bait. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

120

Chemical Diflubenzuron

Reason for not 

performing screen

Woodrow Worksheet:

VP 0.00012 Pa

SOL mg/L 

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) 28-day Inhalation Toxicity Study - Rat/

21-day Inhalation Toxicity Study (MRID 44950601, 

TXR0050266– Rat (Sprague-Dawley, nose only aerosol)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol LOAEL = 0.12 mg/L based on methemoglobinemia (21-day 

study) and NOAEL = 0.109 mg/L (109,000 μg/m3)

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

N/A Yes Yes Yes

Average Hourly Flux Rate (μg/m2-s) 2.81E-02 2.81E-02 2.81E-02

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 109000 109000 109000

UF (unitless) 100 100 100

Concentration of Concern (μg/m3) 1090 1090 1090

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

121

Chemical Diflufenzopyr

Reason for not 

performing screen

Woodrow Worksheet:

VP <1.3x 10-5 Pa 

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 13-week dog feeding study

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 58 mg/kg/day; LOAEL = 403 mg/kg/day based on 

compensated hemolytic anemia.

converted to IEC (μg/m3) 296524

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 4.47E-03

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 296524

UF (unitless) 1000

Concentration of Concern (μg/m3) 297

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

122

Chemical Dikegulac Sodium

Reason for not 

performing screen

No agricultural uses (plant growth regulator for greenhouses and nurseries). No screen 

performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

123

Chemical Dimethenamid

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.5 x 10-2 Pa

SOL 1450 mg/L

Koc 250 mL/g

AR 0.98 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental toxicity study in rats – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) No NOAEL; LOAEL = 25 mg/kg/day based on maternal body weight 

decrement

converted to IEC (μg/m3) 95785

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 5.45E-01 3.07E+00

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 95785 95785

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 96 96

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 970 2,110 3,037 3,876 N/A

Cole crop 4,261 > 4500 > 4500 > 4500 > 4500 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

124

Chemical Dimethoate

Reason for not 

performing screen

Woodrow Worksheet:

VP 0.001 Pa

SOL 39800 mg/L

Koc 20 mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) 21-Day repeated dose inhalation study in rats with Omethoate

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol BMCL10 = 380 μg/m3

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 1.62E-01 1.62E-01 1.62E-01

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 380 380 380

UF (unitless) 100 100 100

Concentration of Concern (μg/m3) 4 4 4

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Row crop 4,180 > 4500 > 4500 > 4500 > 4500 > 4500

Orchard 448 836 1,492 2,074 2,609 N/A
Draft for Comment Version – March 1, 2014

125

Chemical Dimethomorph

Reason for not 

performing screen

Woodrow Worksheet:

VP 9.84 x 10-7 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Rat Developmental ( strain not indicated in DER ) (assumed SD)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) 60

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X (broccoli) X (tomato)

Average Hourly Flux Rate (μg/m2-s) 5.29E-04 5.29E-04

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 229885 229885

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 230 230

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

126

Chemical Dimethyl Disulfide

Reason for not

performing screen

Fumigant

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

127

Chemical Dinotefuran (PC code 044312)

Reason for not 

performing screen

No systemic toxicity was seen in a 28-day inhalation toxicity study at doses that were in ~ 10,000-fold 

excess of the highest anticipated human exposure. There are no developmental toxicity concerns. 

No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

128

Chemical Dioctylsulfosuccinates

Reason for not 

performing screen

As active ingredient- no food uses; As inert- application to crops 

Based on the low toxicity of DSS and its use as a pharmaceutical drug administered in much 

higher doses than would result from any pesticide exposures, a quantitative human health 

risk assessment is not required under registration review for the existing uses of DSS. No 

screen performed at this time.

Woodrow Worksheet:

VP Pa 

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

129

Chemical Diphacinone, and salts

Reason for not 

performing screen

Rodenticide bait. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

130

Chemical Dipropyl isocinchomeratonate

Reason for not 

performing screen

No ag uses, only insecticide repellent in personal products and pet products. RED required 

restriction of no outdoor, aquatic uses, etc. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

131

Chemical Diquat Dibromide

Reason for not 

performing screen

Woodrow Worksheet:

VP 0.00003 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) 21-day inhalation toxicity rat (Fisher 344)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol LOAEL of 0.49 ug/L (0.117 mg/kg/day male, 0.128female) due to 

increased mean lung weight in males, mottling and reddening of 

lungs in females, and lung lesions with NOAEL = 0.1 ug/l (0.024 

mg/kd/d male, 0.026 mg/kd/d female) or 100 μg/m3

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

no Yes Yes Yes

Average Hourly Flux Rate (μg/m2-s) 8.93E-03 8.93E-03 8.93E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 100 100 100

UF (unitless) 100 100 100

Concentration of Concern (μg/m3) 1.00 1.00 1.00

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 658 1,437 2,675 3,752 > 4500 N/A

Row crop 427 1,032 1,996 2,833 3,609 > 4500

Orchard 0 0 0 0 164 N/A
Draft for Comment Version – March 1, 2014

132

Chemical Dithianon

Reason for not 

performing screen

Import uses only. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

133

Chemical Diuron (035505)

Reason for not 

performing screen

Woodrow Worksheet:

VP 9.2 x 10-6 Pa

SOL 36.4 mg/L

Koc 418-560 mL/g

AR Kg/ha

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Oral Study – Developmental Rabbit (New Zealand)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) 10 mg/kg/day (based on LOAEL of 50 for maternal bw effects)

converted to IEC (μg/m3) 73099

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 3.36E-03 3.36E-03 3.36E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 73099 73099 73099

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 73 73 73

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

134

Chemical d-Limonene

Reason for not 

performing screen

d-Limonene is not registered for terrestrial food or feed crop uses as an active ingredient. 

Overall, the database supports the conclusion that high doses of d-limonene (≥500 

mg/kg/day) are needed to induce any form of relevant toxicity in laboratory animals.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

135

Chemical Dodine

Reason for not 

performing screen

Woodrow Worksheet:

VP 2 x 10-5 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental toxicity study in rat – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 10 mg/kg/day; LOAEL = 45 mg/kg/day based on decreased body 

weight gain and food consumption

converted to IEC (μg/m3) 38314

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 7.17E-03 7.17E-03

Application timing Spring Spring

Averaging time for Concentration 6 0.86 6

HEC or IEC (μg/m3) 38314 38314

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 38 38

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

136

Chemical Emamectin Benzoate

Reason for not 

performing screen

Woodrow Worksheet:

VP 4 x 10-6 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 15-day mouse oral

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 0.75 mg/kg/day; LOAEL = 0.1 mg/kg/day based on moribund 

sacrifices, clinical signs of neurotoxicity, decreases in body weight and food 

consumption and histopathological lesions in the sciatic nerve.

converted to IEC (μg/m3) 1799

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 3000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 1.69E-03 1.69E-03

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 1799 1799

UF (unitless) 3000 3000

Concentration of Concern (μg/m3) 0.60 0.60

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 290 457 N/A

Row crop

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

137

Chemical Endosulfan

Reason for not 

performing screen

Scheduled for cancellation

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

138

Chemical Endothall, and salts

Reason for not 

performing screen

Woodrow Worksheet:

VP 5.2 x 10-3 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 2-Generation Reproduction Toxicity Study in Rats – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 9.4 mg/kg/day; LOAEL 60 mg/kg/day based on decreased 

pup body weight (both sexes) on Day 0 F1and F2 generations

converted to IEC (μg/m3) 36015

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 6.34E-01 6.34E-01

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 36015 36015

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 36 36

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 2,144 3,778 > 4500 > 4500 > 4500 N/A

Row crop 1,570 2,823 > 4500 > 4500 > 4500 > 4500

Orchard
Draft for Comment Version – March 1, 2014

139

Chemical Epoxiconazole

Reason for not 

performing screen

Import uses only. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

140

Chemical EPTC

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 4.5 Pa

SOL 344 mg/L

Koc 264 mL/g

AR 4.4 lbai/a Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) 90 day Inhalation toxicity study- Rat

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor Bystanders HEC = 0.329 mg/kg; 2.29 mg/m3

Occupational HEC= 0.461 mg/kg; 9.61 mg/m3

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 30

Representative Crops

Bare Ground Cole/Cotton Row Orchard

x x x

Average Hourly Flux Rate (μg/m2-s) 4.55E+02 1.70E+02 1.70E+02

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 2290 2290 2290

UF (unitless) 30 30 30

Concentration of Concern (μg/m3) 76 76 76

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Cole crop > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Row crop > 4500 > 4500 > 4500 > 4500 > 4500 > 4500

Orchard
Draft for Comment Version – March 1, 2014

141

Chemical Esfenvalerate

Reason for not 

performing screen

Woodrow Worksheet:

VP 6.7x10-5 Pa 

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) ACN – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 1.75 mg/kg/day; LOAEL = 1.90 mg/kg based on tremors.

converted to IEC (μg/m3) 6705

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 1.74E-02

Application timing Spring

Averaging time for Concentration 6 0.86

HEC or IEC (μg/m3) 6705

UF (unitless) 1000

Concentration of Concern (μg/m3) 7

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 67 169 348

Orchard
Draft for Comment Version – March 1, 2014

142

Chemical Ethaboxam

Reason for not 

performing screen

No agricultural uses (import and seed treatment uses only). No screen performed at this 

time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated)

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

143

Chemical Ethalfluralin

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 0.0117 Pa

SOL 0.3 mg/L

Koc 4000 mL/g

AR 1.5 lbai/a Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) 3-Generation Reproduction study in (Fischer 344)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) 12.5 mg/kg/day; The LOAEL = 37.5

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100 (1000)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

x x x

Duration of maximum emission (hours) 4.35E+01 1.24E+00 1.24E+00

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 44326 44326 44326

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 44 44 44

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Cole crop > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Row crop > 4500 > 4500 > 4500 > 4500 > 4500 > 4500

Orchard
Draft for Comment Version – March 1, 2014

144

Chemical Ethametsulfuron (129091)

Reason for not 

performing screen

Only import tolerances will be supported during registration review. The case is to be 

closed, and no additional work will be conducted. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Oral Study – Developmental Rabbit (New Zealand)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) 10 mg/kg/day (based on LOAEL of 50 for maternal bw effects)

converted to IEC (μg/m3) 73099

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

145

Chemical Ethephon

Reason for not 

performing screen

NA

Woodrow Worksheet:

VP 0.000013 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) 28-Day Human Clinical Study

Inhalation study

(no HEC calculated) (μg/m3)

Vapor NA

Aerosol NA

Inhalation study

(HEC calculated) (μg/m3

)

Vapor NA

Aerosol NA

Oral study (mg/kg/day) LOAEL = 1.8 mg/kg/day based on diarrhea and increased urgency 

and frequency of urination, loose stools, stomach cramps or gas

(Inhalation study required in scoping document)

converted to IEC (μg/m3) 50,000 μg/m3

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 300

Representative Crops

Bare Ground Cole/Cotton Row Orchard

no Yes Yes Yes

Average Hourly Flux Rate (μg/m2-s) 4.47E-03 4.47E-03 4.47E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 50000 50000 50000

UF (unitless) 300 300 300

Concentration of Concern (μg/m3) 166.67 166.67 166.67

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

146

Chemical Ethiprole

Reason for not 

performing screen

No agricultural uses in US (imported rice and tea uses only)

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

147

Chemical Ethofumesate

Reason for not 

performing screen

Note: soil incorporated uses.

Woodrow Worksheet:

VP 6.5 x 10-4 Pa

SOL 50 mg/L

Koc 147 mL/g

AR 3.75 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental Toxicity Study in the Rabbit

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) Developmental toxicity NOAEL = 30 mg/kg/day, based

on increased resorptions, postimplantation loss and incomplete 

ossification of the vertebral arches at the LOAEL of 300 mg/kg/day.

converted to IEC (μg/m3) 219298

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 1.62E+00

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 219298

UF (unitless) 1000

Concentration of Concern (μg/m3) 219

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 676 1,710 3,208 4,490 > 4500 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

148

Chemical Ethoprop

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 4.67E-02 Pa

SOL 843 mg/L

Koc 70 mL/g

AR 8 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) CCA study; (Wistar rats)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) 0.14 mg/kg/day (BMDL10); LOAEL = 0.25 mg/kg/day based on brain ChEI 

in pups in the repeated dose comparative cholinesterase study in rats. 

converted to IEC (μg/m3) 516

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 2.10E+01

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 516

UF (unitless) 1000

Concentration of Concern (μg/m3) 1

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

149

Chemical Ethylene Oxide (ETO)

Reason for not 

performing screen

Commodity Fumigant... No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

150

Chemical Etofenprox (PC 128965)

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.3 x 10-6 Pa

SOL N/A mg/L

Koc N/A mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90-day Inhalation Wistar Rat (MRID 40449705)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol NOAEL = 40000 ug/m3 (10.6 mg/kg/day); LOAEL = 2000 ug/m3 (52.3 

mg/kg/day) based on organ weight changes and histopathological 

changes in liver, adrenals and thyroid.

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) N/A

converted to IEC (μg/m3) N/A

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 1.44E-03 1.44E-03 1.44E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 40000 40000 40000

UF (unitless) 100 100 100

Concentration of Concern (μg/m3) 400 400 400

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

151

Chemical Etoxazole

Reason for not 

performing screen

Woodrow Worksheet:

VP 7.0 × 10-6 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Chronic Oral Toxicity Study- Dog

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 4.62 mg/kg/day based upon increased alkaline phosphatase activity, 

increased liver weights, liver enlargement (females), and incidences 

of centrilobular hepatocellular swelling in the liver at 23.5 

mg/kg/day

converted to IEC (μg/m3) 24000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 2.68E-03 2.68E-03 2.68E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 24000 24000 24000

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 24 24 24

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

152

Chemical Fenamidone

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.4 x 10-

7 Pa at 25C

Pa 

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) ST: 90-day feeding study in rats- Sprague-Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 10.4 mg/kg/day; LOAEL = 68.27 mg/kg/day based on 

increased liver weights and incidences of ground glass appearance of 

the hepatocytes in males

converted to IEC (μg/m3) 39847

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 2.20E-04 2.20E-04

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 39847 39847

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 40 40

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

153

Chemical Fenamiphos

Reason for not 

performing screen

There are currently no registrations for fenamiphos in the U.S. (import tolerances only)

Woodrow Worksheet:

VP Pa 

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

154

Chemical Fenarimol

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.9 x 10-5 Pa 

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Special Reproduction Study in Rat - Wistar

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) No NOAEL; LOAEL = 35 mg/kg/day based on decreased fertility and 

dystocia, an indication of hormonal effects.

converted to IEC (μg/m3) 129056

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 8.68E-03 8.68E-03

Application timing Spring Spring

Averaging time for Concentration 6 0.86 6

HEC or IEC (μg/m3) 129056 129056

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 129 129

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

155

Chemical Fenazaquin

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.9 x 10-5 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Rat developmental toxicity – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 10 mg/kg/day; LOAEL = 40 mg/kg/day based on decreased 

body weight gain, food intake, and food efficiency.

converted to IEC (μg/m3) 38314

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 6.12E-03 6.12E-03 6.12E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 38314 38314 38314

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 38 38 38

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

156

Chemical Fenbuconazole

Reason for not 

performing screen

Woodrow Worksheet:

VP 4.9 x 10-6 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90-day oral toxicity in Rat – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 5.1 mg/kg/day; LOAEL = 25.3/31/1 (M/F) mg/kg/day based 

on decreased body weight gain, clinical chemistry changes, and 

histopathological lesions in the liver and thyroid gland.

converted to IEC (μg/m3) 19540

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 2.00E-03 2.00E-03 2.00E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 19540 19540 19540

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 20 20 20

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

157

Chemical Fenbutatin Oxide (Vendex)

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.4E-9 Pa

SOL 0.0127 mg/L

Koc 2300 mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) ST/IT 2 generation Crl Cd:BR rat reproduction study (oral)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL=5.1 mg/kg/day; LOAEL=16.6 mg/kg/day based on f2 pup 

weight gain decrements between LD 0-4 and F2 pup weight 

converted to IEC (μg/m decrement during lactation 3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 3.66E-06 3.66E-06

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 19540 19540

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 20 20

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

158

Chemical Fenhexamid

Reason for not 

performing screen

The HIARC determined that a separate inhalation risk assessment was not required for 

short- and intermediate-term inhalation risk assessments

Woodrow Worksheet:

VP 7x10-9 Torr Pa

SOL 20 mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

x x

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

159

Chemical Fenitrothion

Reason for not 

performing screen

No agricultural uses. Only one import tolerance in wheat gluten and USA registered uses 

for ant and roach bait traps.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

160

Chemical Fenoxaprop-p-ethyl

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP @ 20’C 5.3x10-7 Pa

SOL 0.7 mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) 6-week rat inhalation tox study (FE study)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol 0.14 mg/L (newly calculated)

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

x x

Average Hourly Flux Rate (μg/m2-s) 3.17E-04 3.17E-04

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 140000 140000

UF (unitless) 30 30

Concentration of Concern (μg/m3) 4667 4667

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

161

Chemical Fenoxycarb

Reason for not 

performing screen

No agricultural uses (fire ant bait on turf). No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

162

Chemical Fenpropathrin (127901)

Reason for not 

performing screen

Woodrow Worksheet:

VP 7.3 x 10-4 Pa

SOL 0.33 mg/L

Koc 2.93 x 105 mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Acute Motor Activity Study in Rat (Long-Evans), Wolansky Study 

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) 5.0

converted to IEC (μg/m3) 18,854

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 300

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 1.25E-01 1.25E-01 1.25E-01

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 18854 18854 18854

UF (unitless) 300 300 300

Concentration of Concern (μg/m3) 63 63 63

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 62

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

163

Chemical Fenpyroximate

Reason for not 

performing screen

Woodrow Worksheet:

VP 7.5 × 10-6 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) 28 Day Inhalation toxicity study - Rat

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol 2000 ug/m3 based on increased lung weights, changes in hematology 

parameters (increased counts of erythrocytes), and histopathology 

findings in the nasal passage mucosa consisting of atrophy and 

squamous metaplasia at 10000 ug/m3

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 30

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 2.84E-03 2.84E-03 2.84E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 2000 2000 2000

UF (unitless) 30 30 30

Concentration of Concern (μg/m3) 67 67 67

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

164

Chemical Fenvalerate

Reason for not 

performing screen

Fenvalerate is not included in any products actively registered under FIFRA section 3. The 

Agency has taken actions to cancel any remaining FIFRA section 24(c) Special Local Needs 

registrations with this active ingredient and to propose revocation of any affected 

tolerances that are not supported for import purposes only. No screen performed at this 

time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

165

Chemical Ferbam

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.15 x 10-4 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Combined Chronic Toxicity/Carcinogenicity Study - Rat

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 1.5 mg/kg/day; LOAEL = 7.3 mg/kg/day based on changes in 

hematology, clinical chemistry , incidences of bile duct hyperplasia, 

and reduction in mean body weight gain

converted to IEC (μg/m3) 5531

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 2.71E-02 2.71E-02

Application timing Spring Spring

Averaging time for Concentration 6 0.86 6

HEC or IEC (μg/m3) 5531 5531

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 6 6

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 348 863 1,352 1,791 N/A

Row crop

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

166

Chemical Fipronil

Reason for not 

performing screen

No agricultural uses (indoor, pet, turf, ornamental uses). No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

167

Chemical Flazasulfuron (PC 119011)

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.33x10-5 Pa

SOL N/A mg/L

Koc N/A mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90-Day oral toxicity – Dog (MRID 46220921)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) NOAEL = 2 mg/kg/day; LOAEL = 10 mg/kg/day based on changes in

liver histopathology and clinical chemistry. (D399358)

converted to IEC (μg/m3) 10225

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 4.56E-03 4.56E-03

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 10225 10225

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 10 10

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

168

Chemical Flonicamid (PC 128016)

Reason for not 

performing screen

Woodrow Worksheet:

VP 9.4E-7 Pa

SOL N/A mg/L

Koc N/A mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90-Day oral rat -Wistar

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) NOAEL = 12 mg/kg/day; LOAEL = 60 mg/kg/day based on kidney 

hyaline deposition.

converted to IEC (μg/m3) 44248

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 5.10E-04 5.10E-04

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 44248 44248

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 44 44

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

169

Chemical Florasulam

Reason for not 

performing screen

Woodrow Worksheet:

VP 1 x 10-5 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90-day oral toxicity – dogs

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 5 mg/kg/day; LOAEL = 50 mg/kg/day, based on increased alkaline 

phosphatase activity and increased incidence/severity of hepatic 

vacuolation in both sexes. 

converted to IEC (μg/m3) 25562

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 3.60E-03

Application timing Spring

Averaging time for Concentration 6 0.86

HEC or IEC (μg/m3) 25562

UF (unitless) 1000

Concentration of Concern (μg/m3) 26

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

170

Chemical Fluazinam (129098)

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.3 x 10-5 Pa

SOL 135 mg/L 

Koc 1705-2316 mL/g

AR 1.6 Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) CD rat; 4 week inhalation study (nose-only)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol 0.001 mg/L = 1000 μg/m3

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 30

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X X

Average Hourly Flux Rate (μg/m2-s) 1.63E-03 7.17E-03 7.17E-03 7.17E-03

Application timing Spring Spring Spring Spring

Averaging time for Concentration 6 6 6 6

HEC or IEC (μg/m3) 1000 1000 1000 1000

UF (unitless) 30 30 30 30

Concentration of Concern (μg/m3) 33 33 33 33

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

171

Chemical Flubendiamide

Reason for not 

performing screen

Woodrow Worksheet:

VP 1 x 10-4 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90-day oral toxicity study in the dog

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 2.6 mg/kg/day; LOAEL = 53 mg/kg/day based on liver 

toxicity and adrenal weight increase and increase in adrenal cortical 

cell hypertrophy in females.

converted to IEC (μg/m3) 13292

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 2.42E-02 2.42E-02 2.42E-02

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 13292 13292 13292

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 13 13 13

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

172

Chemical Flucarbazone-sodium

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.3 × 10-7 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Subchronic inhalation toxicity study - Rat

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol 30000 ug/m3 based on eosinophilic globules (nasal cavity) and 

squamous cell metaplasia (larynx) in males and females at 180000 

ug/m3

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 9.93E-05

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 30000

UF (unitless) 100

Concentration of Concern (μg/m3) 300

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 0

Row crop

Orchard
Draft for Comment Version – March 1, 2014

173

Chemical Fludioxonil

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.9 x 10-7 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Rabbit developmental study

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 10 mg/kg/day based upon decreased weight gain during dosing 

period at 100 mg/kg/day.

converted to IEC (μg/m3) 73000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 2.46E-04 2.46E-04 2.46E-04

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 73000 73000 73000

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 73 73 73

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

174

Chemical Flufenacet (PC code 121903)

Reason for not 

performing screen

Woodrow Worksheet:

VP 2 X 10-6 h Pa Pa

SOL 56 mg/L

Koc 113-4602 

(354 used)

mL/g

AR 0.78 Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental Neurotoxicity study in rats- Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) LOAEL = 1.7 mg/kg/day based on decreased body weight/body 

weight gain in pups. NOAEL not identified in this study.

converted to IEC (μg/m3) 6513

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 1.15E-03 9.52E-04 9.52E-04

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 6513 6513 6513

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 6.5 6.5 6.5

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

175

Chemical Flufenoxuron

Reason for not 

performing screen

Import uses only. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

176

Chemical Flumethrin

Reason for not 

performing screen

No agricultural uses (pet collar use)

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Duration of maximum emission (hours)

Maximum percent emitted in duration (%)

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

177

Chemical Flumetralin

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.2 x 10-5 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Subchronic Oral Toxicity - Dog

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 11.6 mg/kg/day; LOAEL = 92.75 mg/kg/day for clinical signs 

(weight loss, decreased food consumption, pyrexia, dehydration, and 

depression), mortality, hematology/ clinical chemistry effects

converted to IEC (μg/m3) 59305

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 9.42E-03

Application timing Spring

Averaging time for Concentration 6 0.86

HEC or IEC (μg/m3) 59035

UF (unitless) 1000

Concentration of Concern (μg/m3) 59

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

178

Chemical Flumetsulam

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 1.3E-13 Pa

SOL 49 mg/L

Koc 3.71E-10 mL/g

AR 0.07 lbai/a Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) Chronic feeding, dog

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) Oral NOAEL = 100 mg/kg/day (inhalation absorption rate = 100%)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 100 

Representative Crops

Bare Ground Cole/Cotton Row Orchard

x x

Average Hourly Flux Rate (μg/m2-s) 2.32E+00 1.09E-09

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 511247 511247

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 511 511

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 465 1,348 2,055 2,682 N/A

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

179

Chemical Flumeturon

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.2e-4 Pa

SOL NA mg/L

Koc NA mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) ST; rat developmental study (oral) CRl: COB CD BR rat; IT: 

subchronic dog study (oral)

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) ST: NOAEL=10 mg/kg/day; LOAEL= 100 mg/kg/day based on delayed 

urinary system development

IT=NOAEL= 10 mg/kg/day; LOAEL=150 mg/kg/day based on 

inflammatory reaction in liver and kidney

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 2.81E-02

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 38314

UF (unitless) 1000

Concentration of Concern (μg/m3) 38

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

180

Chemical Flumiclorac-pentyl

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.33 x 10-5 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Chronic Dog

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 100 mg/kg/day; LOAEL = 1000 mg/kg/day based on 

decreased body weight gain (males), increased clotting time (males 

and females), and increased globulin levels and increased alpha-2 

fraction of the serum protein electrophoresis (females)

converted to IEC (μg/m3) 511247

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 4.56E-03 4.56E-03

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 511247 511247

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 511 511

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

181

Chemical Flumioxazin

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 3.21x10-4 Pa

SOL 1.78 mg/L

Koc 105 mL/g

AR 0.38 lbai/a Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) Oral Developmental Rat Study (Sprague-Dawley)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 3 mg/kg/day

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

x x x x

FAverage Hourly Flux Rate (μg/m2-s) 2.92E+00 6.34E-02 6.34E-02 6.34E-02

Application timing Spring Spring Spring Spring

Averaging time for Concentration 6 6 6 6

HEC or IEC (μg/m3) 11494 11494 11494 11494

UF (unitless) 1000 1000 1000 1000

Concentration of Concern (μg/m3) 11 11 11 11

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Cole crop 0 480 1,136 1,706 2,220 N/A

Row crop 61 302 787 1,231 1,635 2,373

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

182

Chemical Fluometuron

Reason for not 

performing screen

Woodrow Worksheet:

VP 6.7 x 10-5 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental rat study – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 10 mg/kg/day; LOAEL of 100 mg/kg/day, based on delayed 

urinary system development (shortened renal papillae).

converted to IEC (μg/m3) 38314

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 1.74E-02

Application timing Spring

Averaging time for Concentration 6 0.86

HEC or IEC (μg/m3) 38314

UF (unitless) 1000

Concentration of Concern (μg/m3) 38

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

183

Chemical Fluopicolide

Reason for not 

performing screen

Woodrow Worksheet:

VP 8.03 x 10-7 

Pa at 25C

Pa 

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental Toxicity Study in Rabbits with Co-critical: 

Chronic/Oncogenicity Study in Rats

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) Developmental Toxicity Study in Rabbits NOAEL = 20 mg/kg/day; 

LOAEL (maternal) = 60 mg/kg/day based on death, abortions/ premature 

deliveries, decreased food consumption and body weight gain.

Co-critical: Chronic/Oncogenicity Study in Rats NOAEL = 31.5 mg/kg/day; 

LOAEL = 109.4 mg/kg/day based on decreased body weight gain and 

increased thyroid weight and increased incidence of thyroid lesions.

converted to IEC (μg/m3) 146199

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 4.48E-04 4.48E-04 4.48E-04

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 146199 146199 146199

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 146 146 146

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

184

Chemical Fluoxastrobin

Reason for not 

performing screen

Woodrow Worksheet:

VP 5.6 x 10-10 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90-day subchronic dog

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 3 mg/kg/day; LOAEL = M/F 24.8/24.2 mg/kg/day based on doserelated reductions in net body weight gain and food efficiency in addition 

to toxicity findings in the liver (cholestasis) in both sexes, and kidneys 

(increased relative weights in females and degeneration of the proximal 

tubular epithelium in males).

converted to IEC (μg/m3) 15337

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 1.10E-06 1.10E-06

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 15337 15337

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 15 15

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

185

Chemical Fluridone

Reason for not 

performing screen

Aquatic Herbicide, no agricultural uses. No screen performed at this time.

Woodrow Worksheet:

VP Pa 

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

186

Chemical Fluroxypyr, 1-methylheptylester

Reason for not 

performing screen

Woodrow Worksheet:

VP 9.4x10-7 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Chronic/Oncogenity Oral Study – (Sprague-Dawley)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 100 mg/kg/day; LOAEL = 500 mg/kg/day, based on kidney 

effects (increased kidney weights, alterations in clinical chemistry 

parameters indicative of impaired renal functions, and increase in severity 

of chronic progressive glomerulonephropathy in both sexes)

converted to IEC (μg/m3) 6

Duration of Animal Exposure per Day (hrs) 383142

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 5.10E-04 5.10E-04

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 383142 383142

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 383 383

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

187

Chemical Flurprimidol (125701)

Reason for not 

performing screen

No agricultural uses (turf, ornamental, greenhouse uses). No screen performed at this time.

Woodrow Worksheet:

VP 4.8 x 10-5 Pa

SOL 0.12 to 0.14 mg/L

Koc 314 mL/g

AR Kg/ha

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental Rat (Sprague Dawley)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) 10

converted to IEC (μg/m3) 38314

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

188

Chemical Fluthiacet-methyl (PC 108803)

Reason for not 

performing screen

Woodrow Worksheet:

VP 4.4 x 10-7 Pa

SOL N/A mg/L

Koc N/A mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90-day Oral Study – Mouse (MRID 43357804)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) NOAEL = 1.3 mg/kg/day; LOAEL = 66 mg/kg/day, based on effects on 

the erythropoietic system and changes in liver weight, clinical 

chemistry and histopathology

converted to IEC (μg/m3) 3118

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 2.72E-04 2.72E-04

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 3118 3118

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 3 3

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

189

Chemical Flutolanil (PC 128975, Fungicide)

Reason for not 

performing screen

No appropriate endpoint was identified in the database. No screen performed at this time.

Woodrow Worksheet:

VP Pa at 25 oC

SOL mg/L at 20 oC

Koc mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

190

Chemical Flutriafol

Reason for not 

performing screen

Woodrow Worksheet:

VP 4 x 10-7 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental toxicity – rabbit

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 7.5 mg/kg/day; LOAEL = 15 mg/kg/day, based on decreased number 

of live fetuses, complete litter resorptions and increased post-implantation 

loss. 

converted to IEC (μg/m3) 54825

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 2.52E-04 2.52E-04 2.52E-04

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 54825 54825 54825

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 55 55 55

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

191

Chemical Folpet

Reason for not 

performing screen

NA

Woodrow Worksheet:

VP 0.000021 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) Rabbit Developmental Toxicity, gavage, NZW

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor NA

Aerosol NA

Inhalation study

(HEC calculated) (μg/m3

)

Vapor NA

Aerosol NA

Oral study (mg/kg/day) LOAEL = 20 mg/kg/day based on the increase in number of fetuses 

and litters with hydrocephaly and related malformations. NOAEL 

(developmental) = 10 mg/kg/day

converted to IEC (μg/m3) 73,421 μg/m3

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

none none none Yes

Average Hourly Flux Rate (μg/m2-s) 6.65E-03

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 73421

UF (unitless) 1000

Concentration of Concern (μg/m3) 73.42

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

192

Chemical Fomesafen

Reason for not 

performing screen

Woodrow Worksheet:

VP <9.9x10-5 Pa

SOL 50 mg/L at 20 C

Koc 60 mL/g

AR 0.4 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90-day rat- Wistar

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 0.5 mg/kg/day; LOAEL = 10 mg/kg/day based on hyalinization of 

hepatocytes, increased eosinophilia, reduced granulation, increased liver 

weights in males and females, and increases in plasma alkaline 

phosphatase, alanine transminase and aspartate transaminase in males

converted to IEC (μg/m3) 1844

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 9.85E-02

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 1844

UF (unitless) 1000

Concentration of Concern (μg/m3) 2

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

193

Chemical Foramsulfuron (122020)

Reason for not 

performing screen

There were no effects observed in any of the toxicity studies with the chemical, and 

therefore no endpoints for risk assessment were selected. No screen performed at this 

time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

194

Chemical Formetanate HCl

Reason for not

performing screen

Woodrow Worksheet:

VP 2.13x10-4 Pa

SOL mg/L at 20 C

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Comparative Cholinesterase Study (MRID 48298401)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) Brain BMDL10: 0.032 mg/kg; Brain BMD10: 0.041mg/kg based on brain ChE 

data in PND11 female pups (no current appropriate inhalation endpoint)

converted to IEC (μg/m3) 121

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 4.52E-02 4.52E-02

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 121 121

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 0.12 0.12

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop > 4500 > 4500 > 4500 > 4500 > 4500 > 4500

Orchard 3,455 > 4500 > 4500 > 4500 > 4500 N/A
Draft for Comment Version – March 1, 2014

195

Chemical Fosamine Ammonium

Reason for not 

performing screen

Fosamine ammonium is an herbicide applied to non-agricultural rights-of way, industrial 

sites, fencerows, and pine plantations. It is uses for general weed control in 

uncultivated non-agricultural areas (e.g. airports, highway, railroad and utility rights-ofway, sewage disposal areas), uncultivated agricultural areas (e.g., non-crop producing 

farmyards, fuel storage areas, fencerows) and industrial sites (e.g., lumberyards, 

pipeline and tank farms). It is applied as a pre-plant herbicide to pine plantations to 

prevent growth of undesirable seedlings and saplings and suppress growth of brush and 

vines. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

196

Chemical Fosthiazate

Reason for not 

performing screen

There are currently no registered residential uses associated with fosthiazate; therefore, a 

residential/non-occupational exposure assessment is not required. 

Woodrow Worksheet:

VP 0.00056 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) 28 Day Inhalation study in Rats

BMD10= 0.0047 mg/kg/day and BMDL10 = 0.0025 mg/kg/day, based 

on RBC ChE inhibition in rats

Inhalation study

(no HEC calculated) (μg/m3)

Vapor BMDL10 = 0.0025 mg/kg/day, 

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X 

Average Hourly Flux Rate (μg/m2-s) 1.00E-01

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 0.0025

UF (unitless) 100

Concentration of Concern (μg/m3) 0

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop > 4500 > 4500 > 4500 > 4500 > 4500 > 4500

Orchard
Draft for Comment Version – March 1, 2014

197

Chemical Furfural

Reason for not 

performing screen

Soil fumigant like. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

198

Chemical Gamma Cyhalothrin (128897)

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.45E-7 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 21-day Inhalation Study (APfSD Wistar Derived – albino)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol NOAEL: 300 ug/m3

LOAEL: 3300 ug/m3 (clinical signs of neurotoxicity, decreased body 

weight gains, increased incidence of punctate foci in cornea, slight 

reductions in cholesterol in females, slight changes in selected 

urinalysis parameters).

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 2.23E-04 2.23E-04

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 300 300

UF (unitless) 100 100

Concentration of Concern (μg/m3) 3 3

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

199

Chemical Glufosinate

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.2 x 10-9 Pa (25° C)

SOL 1370000 mg/L

Koc 297 (average) mL/g 

AR 0.66 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 28 day inhalation rat- Crl:CD(SD)IGSBR

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol HEC= 6 μg/m3 (S/I-term); 9 μg/m3 (Acute) based on lung/bronchial 

congestion in females, some clinical signs (isolated and transient) 

and liver and kidney weight effects.

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 300

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X X

Average Hourly Flux Rate (μg/m2-s) 2.83E-10 2.06E-06 2.06E-06 2.06E-06

Application timing Spring Spring Spring Spring

Averaging time for Concentration 6 6 6 6

HEC or IEC (μg/m3) 6 6 6 6

UF (unitless) 300 300 300 300

Concentration of Concern (μg/m3) 0.02 0.02 0.02 0.02

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

200

Chemical Glyphosate

Reason for not 

performing screen

Based on the lack of toxicity up to the highest concentration tested (0.36 mg/L) in the 28-

day inhalation toxicity study in rats, the quantification of inhalation risks is not required.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

201

Chemical Halofenozide

Reason for not 

performing screen

Residential turf uses only. No agricultural uses.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

202

Chemical Halosulfuron-Methyl

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 9.33×10-5 Pa at 25°C

SOL 1630

Koc 103

AR 0.094 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental Toxicity - Rabbit

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 50 mg/kg/day; LOAEL = 150 mg/kg/day based on decreased 

body weight gain, food consumption, and food efficiency (maternal 

toxicity).

converted to IEC (μg/m3) 365497

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X X

Average Hourly Flux Rate (μg/m2-s) 8.05E-04 2.28E-02 2.28E-02 2.28E-02

Application timing Spring Spring Spring Spring

Averaging time for Concentration 6 6 6 6

HEC or IEC (μg/m3) 365497 365497 365497 365497

UF (unitless) 1000 1000 1000 1000

Concentration of Concern (μg/m3) 365 365 365 365

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

203

Chemical Hexaflumuron

Reason for not 

performing screen

The only registered use for hexaflumuron is as a bait station/bait application for elimination 

of subterranean termite colonies. Due to the low human exposure potential (i.e., bait 

station/bait application only), many toxicological study requirements were waived for 

hexaflumuron.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

204

Chemical Hexazinone

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 0.000025 Pa

SOL 3.30E+04 mg/L

Koc 54 mL/g

AR 1.5 lbsai/a Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) Developmental Toxicity - Rabbit

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL= 50 (oral) mg/kg/day

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 100 (1000)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

x x

Average Hourly Flux Rate (μg/m2-s) 3.66E-04 8.93E-03

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 365497 365497

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 365 365

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

205

Chemical Hexythiazox

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.4x10-6 Pa at 20C

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 2- gen Repro Study Rat- Fisher and 13-week Feeding Study Rat

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 30 mg/kg/day; 2-Generation Reproduction Study – Rat LOAEL = 

180 mg/kg/day, based on decreased pup body weight during lactation and 

delayed hair growth and/or eye opening, and decreased parental bodyweight gain and increased absolute and relative liver, kidney, and adrenal 

weights

13-Week Feeding Study – Rat LOAEL = 38.1 mg/kg/day, based on increased 

absolute and relative liver weights in both sexes, increased relative ovarian 

and kidney weights, and fatty degeneration of the adrenal zona fasciculate.

converted to IEC (μg/m3) 106383

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 1.48E-03 1.48E-03 1.48E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 106383 106383 106383

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 106.38 106.38 106.38

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

206

Chemical Hydramethylnon (118401)

Reason for not 

performing screen

All end-use products are gel baits, bait stations, or granular products. No screen performed 

at this time.

Woodrow Worksheet:

VP 2.7x10-6 Pa @ 25°C

SOL 0.006 mg/L

Koc 217442 mL/g

AR Kg/ha

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 2-gen repro rat (CD rats; SD-derived)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) NOAEL = 1.66 based on testicular effects seen at LAOEL of 3.22 

converted to IEC (μg/m3) 6360

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

207

Chemical Hydrogen Cyanamide

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 0.005 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) ACGIH 8-hour TWA TLV (human data)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor 2000

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 8

Uncertainty Factors 1

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 6.14E-01

Application timing Spring

Averaging time for Concentration 8

HEC or IEC (μg/m3) 2000

UF (unitless) 1

Concentration of Concern (μg/m3) 2000

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

208

Chemical Hymexazol

Reason for not 

performing screen

Commercial Seed Treatment only - sugar beets. No screen performed at this time.

Woodrow Worksheet:

VP Pa 

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

209

Chemical Imazalil

Reason for not 

performing screen

Uses are for postharvest treatment of citrus fruits and bananas (foreign use on

imported RAC only) and for seed treatment of barley and wheat. No screen performed at 

this time.

Woodrow Worksheet:

VP 1.2 x 10-6 

mm Hg

Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental Rabbit Study, Oral NOAEL - 5.0 (short term)

Chronic Dog Study, Oral NOAEL - 2.5 (intermediate/long term) 

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol

Oral study (mg/kg/day) 2.5 

converted to IEC (μg/m3) 18,275

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

210

Chemical Imazamethabenz

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.51 x 10-6 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Chronic toxicity- dog

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 25mg/kg/day; LOAEL = 100 mg/kg/day based on decreased

body weight in males.

converted to IEC (μg/m3) 127812

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 7.54E-04 7.54E-04

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 127812 127812

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 128 128

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

211

Chemical Imazamox

Reason for not 

performing screen

In a meeting held on 12-JUN-2001, the Hazard Identification Assessment Review Committee 

(HIARC) determined that the toxicological profile of imazamox supports a tolerance 

exemption for this chemical as no adverse effects were observed in the submitted 

toxicological studies regardless of the route of exposure

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

212

Chemical Imazapic

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.0 × 10-9 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Rabbit Developmental Study

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 350 mg/kg/day based on decreased body weight and food 

consumption during dosing at 500 mg/kg/day

converted to IEC (μg/m3) 2600000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 1.78E-06

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 2600000

UF (unitless) 1000

Concentration of Concern (μg/m3) 2600

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

213

Chemical Imazapyr

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 1.2E-8 Pa

SOL 1.13E+04 mg/L

Koc 100 mL/g

AR 1.5 lbai/a Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) 1-Year Dog [feeding] Study

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) Oral study NOAEL= 250 mg/kg/day (inhalation absorption rate = 100%)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors (1000)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

x x

Average Hourly Flux Rate (μg/m2-s) 7.27E-07 4.27E-06

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 1278119 1278119

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 1278 1278

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

214

Chemical Imazaquin

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.7 x 10-6 Pa

SOL 60 mg/L

Koc 38 mL/g

AR 0.125 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Chronic toxicity- dog

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 25 mg/kg/day; based on body weight loss, clinical 

chemistry/hematology differences, slight anemia and the presence 

of skeletal muscle myopathy at a dose of 125 mg/kg/day

converted to IEC (μg/m3) 127812

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 1.99E-03

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 127812

UF (unitless) 1000

Concentration of Concern (μg/m3) 128

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

215

Chemical Imazethapyr

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.1 × 10-9 Pa

SOL 1400 mg/L

Koc 13.2 mL/g

AR 0.094 Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) Developmental Toxicity Study - rabbit

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 300 mg/kg/day based on ulcerations in the mucosal layer of the 

stomach and the gall bladder, increased incidence of clinical signs 

during gestation, increased abortions, and maternal deaths seen at 

1000 mg/kg/day.

converted to IEC (μg/m3) 2200000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 7.04E-07 4.52E-06 4.52E-06

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 2200000 2200000 2200000

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 2200 2200 2200

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

216

Chemical Imidacloprid

Reason for not 

performing screen

Woodrow Worksheet:

VP 4 x 10-10 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Prenatal developmental toxicity – rat (Sprague-Dawley)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 10 mg/kg/day based on decreased maternal body weight gain at 

LOAEL = 30 mg/kg/day

converted to IEC (μg/m3) 38000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 8.32E-07 8.32E-07 8.32E-07

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 38000 38000 38000

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 3800 3800 3800

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

217

Chemical Imiprothrin

Reason for not 

performing screen

No agricultural uses (indoor, non-food use). No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

218

Chemical Indaziflam

Reason for not 

performing screen

Woodrow Worksheet:

VP 6.8 x 10-8 Pa

SOL 4.4 mg/L

Koc 496 mL/g

AR 0.085 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Subchronic Toxicity-Dog

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 7.5 mg/kg/day; LOAEL = 15 mg/kg/day based on 

degenerative brain, spinal cord and sciatic nerve fiber lesions. 

converted to IEC (μg/m3) 38344

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 2.81E-04

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 38344

UF (unitless) 1000

Concentration of Concern (μg/m3) 38

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

219

Chemical Indoxacarb

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.5 x 10-8 Pa

SOL 0.8 (20°C) mg/L

Koc 400 mL/g

AR 0.1125 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 28-day rat inhalation toxicity study (SD)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor NOAEL = 23,000 μg/m3/day; LOAEL of 290,000 μg/m3/day is based 

on increased spleen weights, pigmentation and hematopoiesis in the 

spleen, hematological changes and mortality (females). 

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 4

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

NA X X X

Average Hourly Flux Rate (μg/m2-s) 2.54E-05 2.54E-05 2.54E-05

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 23000 23000 23000

UF (unitless) 100 100 100

Concentration of Concern (μg/m3) 230 230 230

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

220

Chemical Inorg. chlorates

Reason for not 

performing screen

Vapor pressure is classified as zero. Volatilization is expected to be negligible. No screen 

performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

221

Chemical Inorganic Nitrate/Nitrites: Sodium and Potassium Nitrate 076103/104

Reason for not 

performing screen

HED does not believe that new data are needed for Registration Review and that existing 

risk assessments will support Registration Review. There are no pesticidal food uses. No 

screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

222

Chemical Inorganic Polysulfides

Reason for not 

performing screen

Calcium polysulfide readily breaks down in calcium hydroxide and sulfur in the human body. 

These chemicals are assessed separately. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

223

Chemical Inorganic thiosulfates

Reason for not 

performing screen

All products voluntarily cancelled. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

224

Chemical Inorganic Sulfites and Sodium Bisulfite

Reason for not 

performing screen

Fumigant: These products are used in cold-storage warehouses, trucks, vans and train cars 

for post-harvest grape fumigation. No screen performed at this time.

Woodrow Worksheet:

VP Pa 

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

225

Chemical Iodomethane

Reason for not 

performing screen

Soil fumigant. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

226

Chemical Iodosulfuron-methyl

Reason for not 

performing screen

Woodrow Worksheet:

VP 6.7 × 10-9 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Subchronic Oral Toxicity-dog

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 49 mg/kg/day based on alterations in hematological parameters and 

changes in clinical chemistry seen at 4 week observation period t 

301 mg/kg/day

converted to IEC (μg/m3) 250000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 8.55E-06

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 250000

UF (unitless) 1000

Concentration of Concern (μg/m3) 250

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

227

Chemical Ipconazole (125618)

Reason for not 

performing screen

Only use is for seed treatment. No screen performed at this time.

Woodrow Worksheet:

VP Pa 

SOL mg/L

Koc mL/g

AR Kg/ha

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

228

Chemical Iprodione

Reason for not 

performing screen

Woodrow Worksheet:

VP 5x10-7 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Male pubertal assay (Sprague Dawley rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) LOAEL = 50 mg/kg/day based on significant, dose-related reductions 

in serum testosterone levels (↓73%)

converted to IEC (μg/m3) 191571

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 3.02E-04 3.02E-04 3.02E-04

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 191571 191571 191571

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 192 192 192

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

229

Chemical Iron Salts

Reason for not 

performing screen

De minimus - qualitative risk assessment. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

230

Chemical Isoxaben (PC Code 125851)

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.3 x 10-8 Pa

SOL 1.42 at 20°C mg/L

Koc 3.83 at 20°C mL/g

AR 1 Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Two-generation reproductive toxicity in Wistar rat, oral

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 200 mg/kg/day with LOAEL = 1000 mg/kg/day, based on 

increased incidence of malformations

converted to IEC (μg/m3) 737,463

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Y N N N

Average Hourly Flux Rate (μg/m2-s) 2.23E-02

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 737463

UF (unitless) 1000

Concentration of Concern (μg/m3) 737

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

231

Chemical Kasugamycin

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.7 x 10-16 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental toxicity study in rabbits

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 10 mg/kg/day; LOAEL = 30 mg/kg/day (range-finding study), based 

on decreased food consumption, weight loss, abortions (secondary to 

maternal toxicity). 

converted to IEC (μg/m3) 73099

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s) 6.58E-12

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 73099

UF (unitless) 1000

Concentration of Concern (μg/m3) 73

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

232

Chemical Kresoxim-methyl (PC 129111)

Reason for not 

performing screen

Inhalation risk assessments were not previously required. No screen performed at this 

time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

233

Chemical Lactofen

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.69 x 10-5 Pa

SOL 0.97 mg/L

Koc 10,000 mL/g

AR 0.5 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental Rabbit (New Zealand white) SPF

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) LOAEL was 5 mg/kg based on decrease in live young per liver accompanied 

by increases in post implantation loss and in early embryonic death/litter.

converted to IEC (μg/m3) 36550

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 1.83E-02

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 36550

UF (unitless) 1000

Concentration of Concern (μg/m3) 37

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

234

Chemical Lambda Cyhalothrin (128897)

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.0E-7 

(20*C)

Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 21-day Inhalation Study (APfSD Wistar Derived – albino)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol NOAEL: 300 ug/m3

LOAEL: 3300 ug/m3 (clinical signs of neurotoxicity, decreased body 

weight gains, increased incidence of punctate foci in cornea, slight 

reductions in cholesterol in females, slight changes in selected 

urinalysis parameters).

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 1.42E-04 1.42E-04 1.42E-04

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 300 300 300

UF (unitless) 100 100 100

Concentration of Concern (μg/m3) 3 3 3

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

235

Chemical Linuron

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 2.00x10-3 Pa at 24°C

SOL 75 mg/L at 20.5°C

Koc 860 mL/g at 23°C

AR 2.0 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 2-Generation Reproduction Study – Sprague Dawley Rat (no 

inhalation study; waived by HASPOC: TXR#0056436)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL= 5.8; LOAEL= 36 mg/kg/day based decreased premating body 

weights in F0 and F1 animals and histopathological changes in the 

testes of F1 offspring.

converted to IEC (μg/m3) 22222

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 3.78E-01 2.88E-01 2.88E-01

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 22222 22222 22222

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 22 22 22

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 3,035 > 4500 > 4500 > 4500 > 4500 N/A

Cole crop 1,389 2,556 4,495 > 4500 > 4500 N/A

Row crop 995 1,888 3,384 > 4500 > 4500 > 4500

Orchard
Draft for Comment Version – March 1, 2014

236

Chemical Macleaya Extract

Reason for not 

performing screen

Macleaya extract is a plant extract used as ornamental plant fungicide in enclosed 

commercial greenhouses. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

NA NA NA NA

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

237

Chemical Magnesium phophide

Reason for not 

performing screen

All uses have been cancelled. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

238

Chemical Malathion

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 0.000667 Pa

SOL 130 mg/L

Koc 1800 mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) 90-day inhalation study in rats(B6C3F1 and female Fischer 344)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol Inhalation LOAEL= 0.1 mg/L (25.8 mg/kg/day)

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

x x x

Average Hourly Flux Rate (μg/m2-s) 1.16E-01 1.16E-01

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 100000 100000

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 100 100

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

239

Chemical Maleic Hydrazide

Reason for not 

performing screen

NA

Woodrow Worksheet:

VP <10-5 at 25oC Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) One Year Dog Study

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) Systemic LOAEL = 87 mg/kg/day based on decreased weight gain 

in both sexes and reduced heart weight in males. NOAEL of 29 

mg/kg/day

converted to IEC (μg/m3) 148262 ug/m3

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 3.60E-03 3.60E-03

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 148262 148262

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 148 148

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

240

Chemical Mammalian Gonadotropin Releasing Hormone

Reason for not 

performing screen

Deer vaccine. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

241

Chemical Mandipropamid

Reason for not 

performing screen

Woodrow Worksheet:

VP 9.4 x 10-7 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90-day oral toxicity in rats – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 41 mg/kg/day; LOAEL = 260 mg/kg/day, based on 

decreased body weights, body weight gains and food utilization in 

males and slight hepatotoxicity in both sexes.

converted to IEC (μg/m3) 151180

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 5.10E-04 5.10E-04

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 151180 151180

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 151 151

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

242

Chemical Maneb

Reason for not 

performing screen

Inactive labels: No section 3 registered uses. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

243

Chemical MCPA

Reason for not 

performing screen

Woodrow Worksheet:

VP 7.7 x 10-4 Pa

SOL 825 mg/L

Koc 74 mL/g

AR 0.75 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Chronic toxicity and carcinogenicity study in rats (SD)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 4.4 mg/kg/day; LOAEL = 17.6 mg/kg/day based on 

hepatotoxicity and nephrotoxicity at 17.6 mg/kg/day.

converted to IEC (μg/m3) 16224

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 7.37E-02 1.31E-01

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 16224 16224

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 16 16

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 471 1,356 2,064 2,693 N/A

Cole crop 484 1,188 2,277 3,217 4,082 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

244

Chemical MCPB

Reason for not 

performing screen

Woodrow Worksheet:

VP 5.3 x 10-5 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental toxicity in rabbits

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 5 mg/kg/day; LOAEL = 20 mg/kg/day based on maternal 

mortality.

converted to IEC (μg/m3) 36550

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 1.43E-02

Application timing Spring

Averaging time for Concentration 6 0.86

HEC or IEC (μg/m3) 36550

UF (unitless) 1000

Concentration of Concern (μg/m3) 37

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

245

Chemical Mecoprop (MCPP)

Reason for not 

performing screen

No food/feed uses (turf, industrial area uses). No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

246

Chemical Mefluidide

Reason for not 

performing screen

No agricultural uses (ornamental plant growth regulator). No screen performed at this 

time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

247

Chemical Mepiquat-Chloride

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.06 x 10 -4 Pa

SOL mg/L

Koc mL/g

AR 0.0648 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 1-year dog feeding; 90-day dog feeding

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 58.4 mg/kg/day; salivation (indicator of impaired 

neurological function) at the LOAEL of 95.3 mg/kg/day.

converted to IEC (μg/m3) 298569

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 6.09E-02

Application timing Spring

Averaging time for Concentration 6 0.86

HEC or IEC (μg/m3) 298596

UF (unitless) 1000

Concentration of Concern (μg/m3) 299

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

248

Chemical Meptyldinocap

Reason for not 

performing screen

Import uses only. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

249

Chemical Mesotrione

Reason for not 

performing screen

Woodrow Worksheet:

VP 5.7 × 10-6 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Developmental Toxicity Study – rat (Sprague Dawley)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) No NOAEL based upon delays in skeletal ossification and changes in 

manus/pes ossification assessments at 100 mg/kg/day.

converted to IEC (μg/m3) 380000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 3000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 2.26E-03 2.26E-03

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 380000 380000

UF (unitless) 3000 3000

Concentration of Concern (μg/m3) 126.7 126.7

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

250

Chemical Metaflumizone

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.24 x 10-8 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 2-gen. repro. (rat) - Wistar

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 20 mg/kg/day; LOAEL = 50 mg/kg/day based on poor health 

state and decreased bodyweight

converted to IEC (μg/m3) 73746

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 1.42E-05

Application timing Spring

Averaging time for Concentration 6 0.86

HEC or IEC (μg/m3) 73746

UF (unitless) 1000

Concentration of Concern (μg/m3) 74

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

251

Chemical Metalaxyl (PC 113501)

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.3 x 10-3 @ 

25 °C

Pa

SOL N/A mg/L

Koc N/A mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental Toxicity - Sprague Dawley Rat (MRID 00144423)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) NOAEL = 50 mg/kg/day; LOAEL = 250 mg/kg/day, based on clinical 

signs of toxicity including post-dosing convulsions.

converted to IEC (μg/m3) 153257

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare 

Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 4.35E-01 4.35E-01 4.35E-01

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 153257 153257 153257

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 153 153 153

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 302 470 N/A

Row crop 0 0 0 148 265 470

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

252

Chemical Metaldehyde

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.5 x 10-3 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Dog chronic oral toxicity study

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 30 mg/kg/day; LOAEL = 90 mg/kg/day for clinical signs

converted to IEC (μg/m3) 153374

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 2.27E-01 2.27E-01

Application timing Spring Spring

Averaging time for Concentration 6 0.86 6

HEC or IEC (μg/m3) 153374 153374

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 153 153

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

253

Chemical Metam sodium

Reason for not 

performing screen

Fumigant

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

254

Chemical Metconazole

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.2 x 10-5 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90-Day oral toxicity study in rats - Fischer

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 6.4 mg/kg/day; LOAEL = 19.2 mg/kg/day based on increased 

spleen wt (F) and hepatic vacuolation (M).

converted to IEC (μg/m3) 22695

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 4.19E-03 4.19E-03 4.19E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 22695 22695 22695

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 23 23 23

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

255

Chemical Methamidophos

Reason for not 

performing screen

Woodrow Worksheet:

VP 4.0 x 10-2 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90-day Inhalation – Rat

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol NOAEL = 1000 mg/m3; LOAEL = 5000 mg/m3 based on plasma, RBC 

and Brain ChE Inhibition.

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 3.42E+00 3.42E+00

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 1000 1000

UF (unitless) 100 100

Concentration of Concern (μg/m3) 10 10

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Row crop > 4500 > 4500 > 4500 > 4500 > 4500 > 4500

Orchard
Draft for Comment Version – March 1, 2014

256

Chemical Methanearsonic acid, salts (MSMA)

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 1 x 10-5 Pa

SOL 1000000 mg/L

Koc 7000 mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) 90-Day Inhalation with DMA - Rat

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol Inhalation NOAEL= 0.01 mg/L (4.38 mg/kg/day, adjusted)

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

x x

Average Hourly Flux Rate (μg/m2-s) 3.60E-03 3.60E-03

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 10000 10000

UF (unitless) 100 100

Concentration of Concern (μg/m3) 100 100

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

257

Chemical Methidathion

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.5 x 10 -4 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90-day subchronic neurotoxicity in rats – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 0.2 mg/kg/day; LOAEL of 0.6 mg/kg/day based on plasma, 

red blood cell and brain cholinesterase inhibition

converted to IEC (μg/m3) 737

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 5.15E-02 5.15E-02 5.15E-02

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 737 737 737

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 1 1 1

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Row crop > 4500 > 4500 > 4500 > 4500 > 4500 > 4500

Orchard 795 1,405 2,439 3,348 4,183 N/A
Draft for Comment Version – March 1, 2014

258

Chemical Methiocarb

Reason for not 

performing screen

Use on ornamentals, lawns, and non-bearing deciduous and nut trees. Lawn and 

ornamental use in residential setting is solid bait formulation only. No agricultural uses. No

screen performed at this time.

Woodrow Worksheet:

VP Pa 

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

259

Chemical Methomyl

Reason for not 

performing screen

I’m not able to find the tox info

(Since inhalation exposure is anticipated based on the use profile, an acute inhalation study 

is required) 

Woodrow Worksheet:

VP 0.006 Pa

SOL 5.80E+04 mg/L

Koc 72 mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) Acute inhalation rat study (Crl:CD BR)

Inhalation study

(no HEC calculated) (μg/m3

)

0.182 

mg/L

Aerosol 0.182 mg/L

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

x x x

Average Hourly Flux Rate (μg/m2-s) 7.13E-01 7.13E-01 7.13E-01

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 182000 182000 182000

UF (unitless) 100 100 100

Concentration of Concern (μg/m3) 1820 1820 1820

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

260

Chemical Methoxyfenozide (121027)

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.33 X 10-5 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Two week oral study in Beagle dog

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 16.8

converted to IEC (μg/m3) 85,889

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 4.56E-03 4.56E-03 4.56E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 85889 85889 85889

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 86 86 86

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

261

Chemical Methyl Bromide

Reason for not 

performing screen

Methyl bromide is a soil fumigant/commodity fumigant. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

262

Chemical MITC-methyl isothiocynate

Reason for not 

performing screen

Fumigant

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

263

Chemical Methyl parathion

Reason for not 

performing screen

CANCELLED

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

x x

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

264

Chemical Metofluthrin

Reason for not 

performing screen

No agricultural uses (indoor, personal mosquito uses). No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

265

Chemical Metolachlor and S-Metolachlor

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.7 x 10-3 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental Toxicity Study in Rats – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 50 mg/kg/day; LOAEL = 500 mg/kg/day based on is based 

on increased incidence of clinical signs, decreased body weight/body 

weight gain, food consumption and food efficiency seen in maternal 

animals.

converted to IEC (μg/m3) 191571

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 4.78E-01 4.78E-01

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 191571 191571

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 192 192

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 78 292 N/A

Row crop 0 0 0 39 134 305

Orchard
Draft for Comment Version – March 1, 2014

266

Chemical Metrafenone

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.5 x 10-4 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 13-Week Oral Toxicity Study in rat – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 79 mg/kg/day; LOAEL = 404/486 mg/kg/day (M/F) based on 

decreased body weight and body weight gains as well as liver effects 

(vacuolation) in females and increased serum cholesterol and absolute and 

relative liver weight gains observed in both sexes.

converted to IEC (μg/m3) 302682

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 3.38E-02

Application timing Spring

Averaging time for Concentration 6 0.86

HEC or IEC (μg/m3) 302682

UF (unitless) 1000

Concentration of Concern (μg/m3) 303

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

267

Chemical Metribuzin (101101); §180.332

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.6 X 10-5 Pa

SOL 1200 mg/L

Koc ~ 96 

(moderately 

absorbed)

mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) 21-Day Rat Inhalation Toxicity Study 

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol LOAEL for this study is 720 mg/mL3

air , (0.720 mg/L)

NOAEL = 219 mg/mL3 air (0.219 mg/L)

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 100??

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Asparagus 

only x

Average Hourly Flux Rate (μg/m2-s) 5.31E-03 5.31E-03

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 219000 219000

UF (unitless) 100 100

Concentration of Concern (μg/m3) 219 219

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

268

Chemical Metsulfuron (PC 122010)

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.3 x 10-10 Pa

SOL N/A mg/L

Koc N/A mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 2-Generation Reproduction Study – Sprague Dawley Rats (MRID 

00154477)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) NOAEL= 34 mg/kg/day; LOAEL = 342 mg/kg/day based on decreased 

body weights in premating (F0) animals for up to 13 weeks.

converted to IEC (μg/m3) 130268

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 7.10E-07

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 130268

UF (unitless) 1000

Concentration of Concern (μg/m3) 130

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

269

Chemical Metsulfuron-methyl

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.3 X 10-3 Pa

SOL 9500 mg/L

Koc 35 mL/g

AR 0.15 lbai/a Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 2-Gen Repro (CrL:CD(SD)BR)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) 34

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 100 

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X (Cereal 

grains)

Average Hourly Flux Rate (μg/m2-s) 1.48E-02 4.35E-01

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 130268 130268

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 130 130

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop

Row crop 0 0 143 310 454 807

Orchard
Draft for Comment Version – March 1, 2014

270

Chemical Mevinphos

Reason for not 

performing screen

No currently registered products. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

271

Chemical MGK-264

Reason for not 

performing screen

No agricultural uses (indoor, pet, turf, and ornamental uses). No screen performed at this 

time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

N/A Brassica

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

272

Chemical Milbemectin (PC 090105)

Reason for not 

performing screen

No agricultural uses (ornamentals). No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

273

Chemical Myclobutanil

Reason for not 

performing screen

Woodrow Worksheet:

VP 2e-4 Pa

SOL 142 mg/L

Koc 500 mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) ST/IT 2 generation CRL:CD (SD) BR rat reproduction study (oral)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL=10/ LOAEL = 50 mg/kg/day based on atrophy of testes and 

prostrate and increase number of still born pups and decreased pup 

wt gain during lactation

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 7.60E-02

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 38314

UF (unitless) 1000

Concentration of Concern (μg/m3) 38

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 60

Orchard
Draft for Comment Version – March 1, 2014

274

Chemical Naled

Reason for not 

performing screen

NA

Woodrow Worksheet:

VP 0.028 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) 13-week inhalation toxicity study in rats (Fischer-344)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol A NOAEL of 0.23 μg/L (230 μg/m3) based on plasma and RBC 

cholinesterase inhibition at 1.29 μg/L (0.053 mg/kg/day)

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

No Yes Yes Yes

Average Hourly Flux Rate (μg/m2-s) 2.55E+00 2.55E+00 2.55E+00

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 230 230 230

UF (unitless) 100 100 100

Concentration of Concern (μg/m3) 2 2 2

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Row crop > 4500 > 4500 > 4500 > 4500 > 4500 > 4500

Orchard > 4500 > 4500 > 4500 > 4500 > 4500 N/A
Draft for Comment Version – March 1, 2014

275

Chemical Naphthalene

Reason for not 

performing screen

No agricultural uses (animal and moth repellent). No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

276

Chemical Napropamide

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.3 x 10-5 Pa

SOL 74 mg/L

Koc 245 mL/g

AR 6 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Reproductive toxicity in rat – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 30 mg/kg/day; LOAEL = 100 mg/kg/day based on decreased 

pup body weight

converted to IEC (μg/m3) 114943

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 6.10E-02 7.17E-03

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 114943 114943

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 115 115

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

277

Chemical Neodecanamide

Reason for not 

performing screen

No agricultural uses (household insect repellent). No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

278

Chemical Nicarbazin

Reason for not 

performing screen

No agricultural uses (goose bait). No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

279

Chemical Niclosamide

Reason for not 

performing screen

Niclosamide is used by the U.S. Fish and Wildlife Service (USFWS) to control the sea lamprey 

population in the Great Lakes region of the United States. Occupational assessment was 

performed for dermal only. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

280

Chemical Nicosulfuron (herbicide) 

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 1.2x10-14 Pa at 25°C

SOL Anhydrous Form: 

pH 7: 12,200

mg/L at 25°C

Koc 1233 mL/g at 25°C

AR 0.062 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90-Day Oral Toxicity – Dog (no inhalation study; waived by HASPOC: 

TXR#0050011)

Inhalation study

(no HEC currently calculated) 

(μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL=125 mg/kg/day ; LOAEL = 500 mg/kg/day based upon 

decreased body weight gain in males and the statistically significant 

increase in the relative liver and kidney weights of males (D360807)

converted to IEC (μg/m3) 639059

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 2.88E-14 1.52E-10

Application timing Spring Spring

Averaging time for Concentration 6 0.86 6

HEC or IEC (μg/m3) 639059 639059

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 639 639

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

281

Chemical Nitrapyrin 069203, 

Reason for not 

performing screen

Woodrow Worksheet:

VP 0.37 Pa

SOL 92 mg/L

Koc 4675 (range

250-9100)

mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) Rabbit developmental toxicity

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol The waxy physical nature of technical nitrapyrin precludes generating 

aerosols of appropriate atmospheric concentration to meaningfully assess 

inhalation toxicity

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) short-term inhalation: Oral NOAEL= 10

LOAEL = 30 mg/kg/day based on body and liver weight effects. converted to IEC (μg/m3

)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

x

Average Hourly Flux Rate (μg/m2-s) 2.15E+01

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 73099

UF (unitless) 1000

Concentration of Concern (μg/m3) 73

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop > 4500 > 4500 > 4500 > 4500 > 4500 > 4500

Orchard
Draft for Comment Version – March 1, 2014

282

Chemical Norflurazon

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.85x10-6 Pa

SOL 40 mg/L

Koc 1905 mL/g

AR 8 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental Toxicity Study in Rabbits

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 10mg/kg/day; LOAEL = 30 mg/kg/day, based on increased 

incidence in skeletal variations observed.

converted to IEC (μg/m3) 73099

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 4.76E-03

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 73099

UF (unitless) 1000

Concentration of Concern (μg/m3) 73

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

283

Chemical Novaluron

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.3 × 10-5 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) 90-day feeding study in rat (Sprague Dawley)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 4.38 mg/kg/day based on clinical chemistry (decreased hemoglobin, 

hematocrit, and RBC counts) and histopathology (increased 

hematopoiesis and hemosiderosis in spleen and liver) at 8.64 

mg/kg/day

converted to IEC (μg/m3) 17000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 7.17E-03 7.17E-03 7.17E-03

Application timing Spring Spring Spring

Averaging time for Concentration 1 1 1

HEC or IEC (μg/m3) 17000 17000 17000

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 17 17 17

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 0

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 0
Draft for Comment Version – March 1, 2014

284

Chemical Orthosulfamuron (108209)

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 1.3 x 10-4 at 

20°C

Pa

SOL N/A mg/L

Koc N/A mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Two-generation Reproduction Study-Wistar (MRID 46219033)

Inhalation study

(no HEC currently calculated) 

(μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) 88.6

converted to IEC (μg/m3) 326696

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 3.00E-02

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 326696

UF (unitless) 1000

Concentration of Concern (μg/m3) 327

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

285

Chemical Oryzalin

Reason for not 

performing screen

NA

Woodrow Worksheet:

VP 0.000013 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) Rabbit Developmental Study

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor NA

Aerosol NA

Inhalation study

(HEC calculated) (μg/m3)

Vapor NA

Aerosol NA

Oral study (mg/kg/day) LOAEL = 55 mg/kg/day based on decreased body weight gain and food 

consumption in does

NOAEL= 25 mg/kg/day

converted to IEC (μg/m3) 183554 μg/m3

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

NO NO NO Pome

Average Hourly Flux Rate (μg/m2-s) 4.47E-03

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 183554

UF (unitless) 1000

Concentration of Concern (μg/m3) 184

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

286

Chemical Oxamyl; 103801

Reason for not 

performing screen

Woodrow Worksheet:

VP 5.12*10^-5 Pa

SOL 280000 mg/L

Koc 17 mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) Acute inhalation rat (45155801)

RBC BMD10= 0.002 mg/L

RBC BMDL10= 0.0018 mg/L,

based on RBC AChE inhibition in both sexes.

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol RBC BMD10= 0.002 mg/L

RBC BMDL10= 0.0018 mg/L,

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol RBC Occupational: HEC = 2250 mg/m3 

RBC Non-Occupational: HEC= 750 mg/m3

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors (300)?

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 1.39E-02 1.39E-02 1.39E-02

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 750000 750000 750000

UF (unitless) 300 300 300

Concentration of Concern (μg/m3) 2500 2500 2500

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

287

Chemical Oxydemeton-methyl (ODM)

Reason for not 

performing screen

Woodrow Worksheet:

VP 0.0038 Pa

SOL Miscible in 

any ratio

mg/L

Koc 29 mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) Acute inhalation study in rat

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol LOAEL= 17 mg/kg/day based on clinical signs (tremors) 0.177 mg/L

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 4 hrs rat inhalation

Uncertainty Factors 300

Representative Crops

Bare Ground Cole/Cotton Row Orchard

x X X X

Average Hourly Flux Rate (μg/m2-s) 4.89E-01 4.89E-01 4.89E-01

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 177000 177000 177000

UF (unitless) 300 300 300

Concentration of Concern (μg/m3) 590 590 590

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

288

Chemical Oxytetracycline

Reason for not 

performing screen

Based on information obtained in the web it is estimated to be 9.7x10-25 mmHg. No 

inhalation toxicity studies are available and endpoints have not been selected for a 

quantitative occupational assessment. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Estimated vapor pressure is 9.7X10-25 mm Hg at 25 deg C. 

(http://testpubchem.ncbi.nlm.nih.gov/toc/summary_toc.cgi?tocid=351&sid=8850).

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

289

Chemical Paclobutrazol; 125601

Reason for not 

performing screen

No agricultural use. Used in turf, outdoor ornamentals, greenhouse ornamentals and bulb 

soaks

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

290

Chemical Paraquat Dichloride

Reason for not 

performing screen

NA

Woodrow Worksheet:

VP 0.00000013 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) 21-Day inhalation toxicity study in rats (respirable particles)

3-generation reproduction study (non-respirable particles)

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol LOAEL = 0.10 μg/L, based on squamous keratinizing metaplasia and 

hyperplasia of the epithelium of the larynx or 10 μg/m3 for 

respirable particles, 

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 0.01 μg/L for respirable particles

NOAEL = 1.25 mg/kg/day for non-respirable particles

converted to IEC 

(μg/m3)

4789 μg/m3 for non-respirable.

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100 for both respirable and non-respirable.

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 6.67E-04 6.67E-04 6.67E-04

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 10 10 10

UF (unitless) 100 100 100

Concentration of Concern (μg/m3) 0.10 0.10 0.10

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 298 785 1,650 2,383 3,052 N/A

Row crop 180 517 1,194 1,765 2,290 3,250

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

291

Chemical para-Dichlorobenzene

Reason for not 

performing screen

No agricultural uses (indoor uses only). No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

292

Chemical Pendimethalin

Reason for not 

performing screen

Woodrow Worksheet:

VP 4E-3 Pa (3x10^-5 mmhg)

SOL 0.275 mg/L

Koc 5000 mL/g

AR 1.5 lbs ai/a Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) 92- Day thyroid function study in rats; 56- day thyroid study in rats 14- day intra 

thyroid metabolism study in rats. Note: I guess, SD stands for Sprague-Dawley 

strains

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) LOAEL = 31 mg/kg/day based on hormonal and histopathological changes in the 

thyroid. NOAEL = 10 mg/kg/day converted to IEC (μg/m3

)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Pre-emergence 

herbicide 

X x X

Average Hourly Flux Rate (μg/m2-s) 1.52E+01 5.10E-01 5.10E-01 5.10E-01

Application timing Spring Spring Spring Spring

Averaging time for Concentration 6 6 6 6

HEC or IEC (μg/m3) 38314 38314 38314 38314

UF (unitless) 1000 1000 1000 1000

Concentration of Concern (μg/m3) 38 38 38 38

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Cole crop 1,453 2,654 > 4500 > 4500 > 4500 N/A

Row crop 1,041 1,964 3,509 > 4500 > 4500 > 4500

Orchard 0 0 236 390 530 N/A
Draft for Comment Version – March 1, 2014

293

Chemical Penoxsulam (119031)

Reason for not 

performing screen

Woodrow Worksheet:

VP 9.55 x 1014 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 13-week oral in beagle dog

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 17.8

converted to IEC (μg/m3) 91,002

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 8.42E-10 8.42E-10

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 91002 91002

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 91 91

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

294

Chemical Pentachloronitrobenzne (PCNB)

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 0.0151 Pa

SOL 0.44 mg/L

Koc 5000 mL/g

AR 30 Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) Nonguideline 90-day subchronic oral toxicity study in male rats

(Wister)

Inhalation study

(no HEC currently calculated) 

(μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 1 mg/kg/day; LOAEL = 333 mg/kg/day based on thyroid 

follicular epithelial hypertrophy observed after 14 & 30 days.

converted to IEC (μg/m3) 3831

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X x x

Average Hourly Flux Rate (μg/m2-s) 4.33E+02 1.53E+00 1.53E+00

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 3831 3687 3687

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 4 4 4

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Cole crop > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Row crop > 4500 > 4500 > 4500 > 4500 > 4500 > 4500

Orchard
Draft for Comment Version – March 1, 2014

295

Chemical Permethrin

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.9x10-6 Pa

SOL 0.006 mg/L

Koc 100000 mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) 15-Day Inhalation Study in Rats

LOAEL = 0.583 mg/l (converts to oral equivalent of 154 mg/kg/day) based on body 

tremors and hypersensitivity to noise. NOAEL= 0.042 mg/l (Converts to oral 

equivalent of 11 mg/kg/day)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol NOAEL= 0.042 mg/l (Converts to oral equivalent of 11 mg/kg/day)

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

x X X X

Average Hourly Flux Rate (μg/m2-s) 1.80E-02 1.80E-02 1.80E-02

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 42000 42000 42000

UF (unitless) 100 100 100

Concentration of Concern (μg/m3) 420 420 420

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 0

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 0
Draft for Comment Version – March 1, 2014

296

Chemical Phenmedipham

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.3e-7 Pa

SOL 4.7 mg/L

Koc 2400 mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) ST/IT chronic rat toxicity/carcinogenicity study (oral)—HAN Wistar

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL=24 mg/kg/day/ LOAEL=118/171 mg/kg/day for 

females/males, resp. based on hemolytic anemia in both sexes and 

decreased BW/BW gain and food efficiency in females and increase 

renal pelvic epithelial hyperplasia and mineralization in males

converted to IEC 

(μg/m3

)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 9.93E-05

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 88496

UF (unitless) 1000

Concentration of Concern (μg/m3) 88

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

297

Chemical Phenothrin (sumithrin)

Reason for not 

performing screen

Phenothrin is not currently registered for direct application to agricultural crops and there 

are no tolerances for specific raw agricultural commodities. However, use of phenothrin 

over agricultural lands is considered a food use and a single tolerance is established in/on 

all crops for this use. Phenothrin is used to control adult mosquitoes indoors and outdoors 

in residential and commercial areas. Phenothrin is also used directly on pets. No screen 

performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

298

Chemical Phorate

Reason for not 

performing screen

Note: Granular products only. All applications soil incorporated. Screen is likely very 

conservative.

Woodrow Worksheet:

VP 1.12x10-1 Pa

SOL 50 mg/L

Koc 1660 mL/g

AR 3.9 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Acute Neurotoxicity Rat – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study mg/kg/day NOAEL = 0.25 mg/kg/day; LOAEL = 0.5 mg/kg based on miosis and 

brain cholinesterase inhibition

converted to IEC (μg/m3) 958

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 1.79E+01

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 958

UF (unitless) 1000

Concentration of Concern (μg/m3) 1

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

299

Chemical Phosalone

Reason for not 

performing screen

No registered products. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

300

Chemical Phosmet

Reason for not 

performing screen

Woodrow Worksheet:

VP 6.5x10-5 Pa 

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 7-day repeat oral CCA study in Rats - Crl:CD (SD) rats

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) Occupational ST/IT: oral BMDL10 = 0.6 mg/kg/day; BMD10 = 1.19 

mg/kg/day (adult RBC ChEI; grouped)

converted to IEC (μg/m3) 2299

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 1.69E-02 1.69E-02 1.69E-02

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 2299 2299 2299

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 2 2 2

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 397 989 1,963 2,798 3,564 N/A

Row crop 250 680 1,440 2,093 2,691 3,792

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

301

Chemical Phosphine, Aluminum Phosphide, Magnesium Phosphide

Reason for not 

performing screen

Commodity Fumigant....No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

302

Chemical Picaridin (070705)

Reason for not 

performing screen

The active ingredient is only used as a repellent, directly applied to skin; there are no 

registered ag. uses. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

303

Chemical Picloram (005101)

Reason for not 

performing screen

Woodrow Worksheet:

VP 8.3 x 10-5 Pa

SOL 7.2342 mg/L

Koc 13 mL/g

AR 0.5 Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90-day dietary rat study (F344)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL is 50 mg/kg/day based on a LOAEL of 150 mg/kg/day with 

liver weight changes and minimal microscopic changes in the liver. 

Note: no inhalation endpoints were chosen in the original risk 

assessment (1994) because it was not required because “no 

endpoints were identified for either the oral or dermal routes for 

short and intermediate term exposures that could be extrapolated 

to the inhalation route of exposure”. Presented here is the lowest 

NOAEL from an oral study with short term duration.

converted to IEC (μg/m3) 177305

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

yes

Average Hourly Flux Rate (μg/m2-s) 2.08E+00

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 177305

UF (unitless) 1000

Concentration of Concern (μg/m3) 177

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 1,860 3,385 > 4500 > 4500 > 4500 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

304

Chemical Piperalin

Reason for not 

performing screen

Qualitative assessment since only niche use on roses in greenhouses, HASPOC waived tox 

requirements, PPE required on labels. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

305

Chemical Piperonyl Butoxide (PBO)

Reason for not 

performing screen

NA

Woodrow Worksheet:

VP 0.000013 Pa

SOL 14.3 mg/L mg/L

Koc 399 - 830 

mL/g

mL/g

Tox Study Information

Type and Duration (include strain of rat) Acute: Developmental toxicity study, rats (Tanaka et al., 1995a)

ST: Subchronic inhalation toxicity study, rats (Sprague 

Dawley)aerosol (42477101)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol ST: Respiratory LOAEL = 3.91 mg/kg/day (0.015 mg/L) based on 

laryngeal hyperplasia and metaplasia, No NOAEL or 15000 μg/m3

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) Acute: LOAEL = 1065 mg/kg/day based on decrease in maternal body 

weight gain. NOAEL 630 mg/kg.

converted to IEC (μg/m3) Acute: 2,413,793 μg/m3

Duration of Animal Exposure per Day (hrs) 6 hrs

Uncertainty Factors Acute: 100, ST: 300

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 4.47E-03 4.47E-03

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 15000 15000

UF (unitless) 100 100

Concentration of Concern (μg/m3) 150 150

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

306

Chemical Pirimicarb

Reason for not 

performing screen

No active registrations. No screen performed at this time.

Woodrow Worksheet:

VP Pa 

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

307

Chemical Pirimiphos-methyl (108102)

Reason for not 

performing screen

The only use pattern is post-harvest, on stored grains. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

308

Chemical Prallethrin (128722)

Reason for not 

performing screen

No agricultural uses (indoor, mosquito). No screen performed at this time.

Woodrow Worksheet:

VP 4.67 x 10-3 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 28-Day Inhalation Study, Sprague Dawley Rats

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol 1,010 μg/m3 (Median diameter of mist particles: 4.89 micrometers)

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 4 hours/day

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

309

Chemical Primisulfuron-methyl

Reason for not 

performing screen

Woodrow Worksheet:

VP 5e-6 Pa

SOL N/A mg/L

Koc N/A mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) 2-Generation repro study in rats (MRID 40512009 , Crl:COBS®CD®(SD)BR 

rats)

LOAEL = 250 mg/kg/day based on F1 gen decr. pup wgts.

Oral NOAEL – 50 mg/kg/day

100% absorption

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors UFH=10X; UFA=10X; IA = 100%

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 2.03E-03

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 191571

UF (unitless) 1000

Concentration of Concern (μg/m3) 192

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

310

Chemical Prodiamine

Reason for not 

performing screen

Screen performed for sod farm use

Woodrow Worksheet:

VP 0.0000033 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) Chronic/cancer rat (sprague dawley) study

Inhalation study

(no HEC calculated) (μg/m3)

Vapor NA

Aerosol NA

Inhalation study

(HEC calculated) (μg/m3

)

Vapor NA

Aerosol NA

Oral study (mg/kg/day) NOEL 7.2 MKD

converted to IEC (μg/m3) 27,586 μg/m3

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

No No No No

Average Hourly Flux Rate (μg/m2-s) 1.44E-03

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 27586

UF (unitless) 1000

Concentration of Concern (μg/m3) 28

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

311

Chemical Profenofos Insecticide- miticide (probably not bare ground)

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.2E-4 Pa

SOL 20 mg/L

Koc 840 mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) 21 day inhalation study - rats

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol LOAEL= 0.068 mg/L based on plasma, RBC and brain ChE Inhibition at the 

lowest dose tested.; LOAEL = 0.068 mg/L 17 mg/kg/day;

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors LOAEL only assumed to be an extra 3X (no recent assessments)-

300X

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

At planting x x

Average Hourly Flux Rate (μg/m2-s) 2.81E-02 2.81E-02

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 68000 68000

UF (unitless) 300 300

Concentration of Concern (μg/m3) 227 227

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

312

Chemical Prohexadione calcium

Reason for not 

performing screen

Woodrow Worksheet:

VP 9.3 x 10-5 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Prenatal Developmental Toxicity – Rabbit

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 40 mg/kg/day based on increased mortality, abortions, and 

decreased maternal body-weight gain at 200 mg/kg/day

converted to IEC (μg/m3) 290000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 2.28E-02 2.28E-02

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 290000 290000

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 290 290

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

313

Chemical Prometon

Reason for not 

performing screen

No agricultural uses (industrial sites, spot turf treatment). No screen performed at this 

time. 

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

314

Chemical Prometryn

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.1 × 10-4 Pa

SOL 33 mg/L

Koc 400 mL/g

AR 3.2 Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) Developmental toxicity (rabbit)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 12 mg/kg/day based on increased incidence of resorptions, 

abortions, and post-implantation loss leading to decreased number 

of viable litters and live fetuses at 72 mg/kg/day

converted to IEC (μg/m3) 88000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 6.60E-02

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 88000

UF (unitless) 1000

Concentration of Concern (μg/m3) 88

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

315

Chemical Pronamide (Propyzamide)

Reason for not 

performing screen

Woodrow Worksheet:

VP 0.0113 Pa

SOL 15 mg/L

Koc 800 mL/g

AR 4 Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) Developmental Toxicity Study - Rabbit

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) oral study NOAEL = 8.46 mg/kg/day inhalation

converted to IEC (μg/m3) 61842

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 300

Representative Crops

Bare Ground Cole/Cotton Row Orchard

x x x x

Average Hourly Flux Rate (μg/m2-s) 1.34E+00 1.20E+00 1.20E+00 1.20E+00

Application timing Spring Spring Spring Spring

Averaging time for Concentration 6 6 6 6

HEC or IEC (μg/m3) 61842 61842 61842 61842

UF (unitless) 300 300 300 300

Concentration of Concern (μg/m3) 206 206 206 206

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Cole crop 133 547 1,282 1,896 2,454 N/A

Row crop 93 352 902 1,382 1,819 2,619

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

316

Chemical Propachlor

Reason for not 

performing screen

Woodrow Worksheet:

VP 9.99 x 10-2 Pa

SOL 613 mg/L

Koc 73 mL/g

AR 6 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) ACN in rats – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 175 mg/kg/day; LOEL is 350 mg/kg, based on an increase in 

landing foot splay at 7 hours [peak effect time]

in females

converted to IEC (μg/m3) 670498

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 4.00E+01

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 670489

UF (unitless) 1000

Concentration of Concern (μg/m3) 670

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

317

Chemical Propamocarb

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.9 x 10-5 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) 2-Gen Repro – rat (Sprague Dawley)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 65.41 mg/kg/day based on reduced pup weights in F0 & F1 during Day 14 -

21 of lactation and adults at 406 mg/kg/day

converted to IEC (μg/m3) 250000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 1.11E-02 1.11E-02

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 250000 250000

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 250 250

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

318

Chemical Propanil

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.6e-5 Pa

SOL 200 mg/L

Koc 149 mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) ST/IT: chronic toxicity/carcinogenicity study rats (oral) Sprague 

Dawley

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) LOAEL=9 mg/kg/day based on increased methemoglobin and 

increased spleen wt in females and small seminal vesicles and 

prostrate in males

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 300 (includes 3X L to N)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 7.93E-03

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 34438

UF (unitless) 3000

Concentration of Concern (μg/m3) 11

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

319

Chemical Propargite

Reason for not 

performing screen

NA

Woodrow Worksheet:

VP 0.000006 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) Acute Inhalation in Rats 42857003, Increased mortality at 0.31 mg/L (LOAEL) in 

males. LOAEL= 0.31mg/L, No NOAEL. No respiratory histopath. Was used for all 

inhalation durations

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol 310,000 μg/m3

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 4

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 2.36E-03 2.36E-03 2.36E-03

Application timing Spring Spring Spring

Averaging time for Concentration 4 4 4

HEC or IEC (μg/m3) 310000 310000 310000

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 310 310 310

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

320

Chemical Propazine

Reason for not 

performing screen

Sorghum only

Woodrow Worksheet:

VP 3.87x10-6 Pa

SOL 3.8 mg/L

Koc 173 mL/g

AR 1.2 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Pubertal assay in rats - Wistar

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Inhalation study

(HEC calculated)

(μg/m3

)

Oral study (mg/kg/day) NOAEL = 6.25 mg/kg/day; LOAEL = 12.5 mg/kg/day based on 

delayed preputial separation in male offspring after 30 days of dosing

converted to IEC (μg/m3) 23046

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 6.14E-02

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 23046

UF (unitless) 1000

Concentration of Concern (μg/m3) 23

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 168 672 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

321

Chemical Propiconazole

Reason for not 

performing screen

Woodrow Worksheet:

VP 5.6 x 10-5 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Acute Neurotoxicity Study in Rats - Wistar

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 30 mg/kg/day; LOAEL = 100 mg/kg/day based on clinical 

signs of toxicity (piloerection in one male, diarrhea in one female, tip 

toe gait in 3 females).

converted to IEC (μg/m3) 110619

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 1.50E-02 1.50E-02

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 110619 110619

UF (unitless) 100 100

Concentration of Concern (μg/m3) 1106 1106

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

322

Chemical Propetamphos

Reason for not 

performing screen

Voluntarily cancelled during Registration Review.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

323

Chemical Propionic acid, and salts

Reason for not 

performing screen

No agricultural uses (stored grain uses, poultry litter uses). No screen performed at this 

time. 

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

324

Chemical Propoxur

Reason for not 

performing screen

Not for use on agricultural settings (only for FHE)

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

325

Chemical Propoxycarbazone-sodium

Reason for not 

performing screen

Woodrow Worksheet:

VP 9.9 × 10-9 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Developmental Study in Rabbits

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 100 mg/kg/day based on GI toxicity (enlarged cecum, reduced and 

light-colored feces) at 500 mg/kg/day.

converted to IEC (μg/m3) 730000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 1.18E-05

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 730000

UF (unitless) 1000

Concentration of Concern (μg/m3) 730

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

326

Chemical Propylene oxide

Reason for not 

performing screen

Commodity Fumigant....No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

327

Chemical Prosulfuron

Reason for not 

performing screen

Woodrow Worksheet:

VP < 3.5x10-6 Pa

SOL 4000 mg/L

Koc 17

Highly mobile

mL/g

AR 0.0356 lb 

ai/a

Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) Subchronic Oral Toxicity Study - Dog

LOAEL = 54 mg/kg/day, based on decreased body-weight gain and feed 

efficiency, hematological findings and hepatotoxicity in both sexes.; NOAEL 

= 5.3 mg/kg/day

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X x

Average Hourly Flux Rate (μg/m2-s) 4.38E-05 1.51E-03

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 27096 27096

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 27 27

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

328

Chemical Prothioconazole

Reason for not 

performing screen

Woodrow Worksheet:

VP 4 x 10-7 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental Toxicity study in rabbits

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 2.0 mg/kg/day; LOAEL = 10 mg/kg/day based on structural

alterations including malformed vertebral body and ribs, 

arthrogryposis, and multiple malformations.

converted to IEC (μg/m3) 14620

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 2.52E-04 2.52E-04

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 14620 14620

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 15 15

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

329

Chemical Pymetrozine (101103)

Reason for not 

performing screen

Woodrow Worksheet:

VP <4 x 10-6 Pa

SOL 290 mg/L

Koc mL/g

AR Kg/ha

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental Neurotox Study with Sprague-Dawley Rats

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) LOAEL = 8.1

converted to IEC (μg/m3) 31,034

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 1.69E-03 1.69E-03 1.69E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 31034 31034 31034

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 31 31 31

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

330

Chemical Pyraclostrobin (PC 099100)

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.6 X 10-8 at 

20o C

Pa

SOL 1.9 (pH 5.8) mg/L

Koc 9304

(range 

6000-

16000)

mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 28-day Inhalation – Wistar Rat (MRID 46638801)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol NOAEL= 0.23 mg/kg/day (1000 ug/m3); LOAEL = 6.9 mg/kg/day 

(30000 ug/m3) based on duodenum mucosal hyperplasia and 

respiratory system findings including alveolar histiocytosis and 

olfactory atrophy/necrosis in nasal tissue.

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) N/A

converted to IEC (μg/m3) N/A

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 2.62E-05 2.62E-05 2.62E-05

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 1000 1000 1000

UF (unitless) 100 100 100

Concentration of Concern (μg/m3) 10 10 10

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

331

Chemical Pyraflufen-ethyl (PC 030090)

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 5.73 x 10-7 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental Toxicity – Rabbit (MRID 45282918)

Inhalation study

(no HEC currently calculated) 

(μg/m3)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) NOAEL = 20 mg/kg/day; LOAEL = 60 mg/kg/day based on

decreases in body weight and food consumption, GI observations, 

and abortions

converted to IEC (μg/m3) 146199

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 3.39E-04 3.39E-04 3.39E-04

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 146199 146199 146199

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 146 146 146

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

332

Chemical Pyrasulfotole

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.7 x 10-7 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Combined chronic toxicity/carcinogenicity (rat; dietary) - Wistar

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 1 mg/kg/day; LOAEL = 10/14 mg/kg/day (M/F) based on corneal 

opacity, neovascularization of the cornea, inflammation of the cornea, 

regenerative corneal hyperplasia, corneal atrophy, and/or retinal atrophy 

(both sexes), and hepatocellular hypertrophy along with increased serum 

cholesterol (males).

converted to IEC (μg/m3) 3687

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 1.82E-04 1.82E-04

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 3687 3687

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 4 4

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

333

Chemical Pyrethrin (and derivatives)

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.67E-03 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Subchronic inhalation toxicity study in rats (sprague dawley)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol NOAEL = 30000 ug/m3; LOAEL of 100000 ug/m3 based on tremors, 

labored breathing, hyperactivity, secretory signs, matted coat, 

decreased body weight and body-weight gain

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 300

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 3.65E-01 3.65E-01 3.65E-01

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 30000 30000 30000

UF (unitless) 300 300 300

Concentration of Concern (μg/m3) 100 100 100

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 392 650 938 N/A

Row crop 0 0 224 408 614 1,023

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

334

Chemical Pyridaben

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 1.6 x 10-4 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 30-Day Inhalation Toxicity Study in Rats

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol 870 ug/m3 (0.00087 mg/L) at LOAEL = 3000 ug/m3 (0.003 mg/L) 

based on an increased incidence of dried red nasal discharge, 

decreased body weight gain and decreased albumin levels. 

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) N/A

converted to IEC (μg/m3) N/A

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 3.56E-02 3.56E-02

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 870 870

UF (unitless) 100 100

Concentration of Concern (μg/m3) 8.70 8.70

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 539 893 1,238 N/A

Row crop

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

335

Chemical Pyridalyl

Reason for not 

performing screen

Woodrow Worksheet:

VP 6.2 x 10-8 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 2-Generation Reproduction Study in Rat – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 2.8 mg/kg/day; LOAEL = 13.8 mg/kg/day, based on 

decreased thymus weights.

converted to IEC (μg/m3) 10728

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 5.38E-05

Application timing Spring

Averaging time for Concentration 6 0.86

HEC or IEC (μg/m3) 10728

UF (unitless) 1000

Concentration of Concern (μg/m3) 11

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

336

Chemical Pyridate (PC code 128834)

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.3E-05 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90-day feeding study in dogs (Beagle)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 20 mg/kg/day; LOAEL = 60 mg/kg/day based on ataxia and

emesis.

converted to IEC (μg/m3) 102249

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 4.47E-03

Application timing Spring

Averaging time for Concentration 6 0.86

HEC or IEC (μg/m3) 102249

UF (unitless) 1000

Concentration of Concern (μg/m3) 102

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

337

Chemical Pyrimethanil

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.2 x 10-3 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Reproductive Toxicity in Rat – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NAOEL =23.1 mg/kg/day; LOAEL = 294 mg/kg/day based on 

decreased mean body weights and body-weight gains.

converted to IEC (μg/m3) 88506

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 3.11E-01 3.11E-01

Application timing Spring Spring

Averaging time for Concentration 6 0.86 6

HEC or IEC (μg/m3) 88506 88506

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 89 89

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 345 592 846 N/A

Row crop

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

338

Chemical Pyriproxyfen

Reason for not 

performing screen Based on the absence of biologically relevant toxicity at the LOAEL of 1.0 mg/L, the 

quantification of inhalation risks is not required. In addition, no developmental concerns 

(toxicity) were seen in either rats or rabbits. 

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) Based on the absence of biologically relevant toxicity at the LOAEL of 

1.0 mg/L, the quantification of inhalation risks is not required. In 

addition, no developmental concerns (toxicity) were seen in either 

rats or rabbits. 

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Duration of maximum emission (hours)

Maximum percent emitted in duration (%)

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

339

Chemical Pyrithiobac

Reason for not 

performing screen

Woodrow Worksheet:

VP 4.8 x 10-9 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Combined Chronic/Carcinogenicity – rat (Sprague Dawley)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 58.7mg/kg/day based on decreased body weight, body weight gain, 

decreases in hematocrit and red blood cells, and treatment related 

Hematuria in males at 200 mg/kg/day (Note this is the chronic 

dietary POD as no inhalation POD has been previously selected.)

converted to IEC (μg/m3) 220000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 6.49E-06

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 220000

UF (unitless) 1000

Concentration of Concern (μg/m3) 220

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

340

Chemical Pyroxsulam

Reason for not 

performing screen

Woodrow Worksheet:

VP 7.5 x 10-10 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Carcinogenicity study in mice

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 100 mg/kg/day; LOAEL = 1000 mg/kg/day based on 

increased absolute and relative liver weights and increased 

incidence of hepatocellular clear cell foci of alteration in males

converted to IEC (μg/m3) 239808

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 1.40E-06

Application timing Spring

Averaging time for Concentration 6 0.86

HEC or IEC (μg/m3) 29808

UF (unitless) 1000

Concentration of Concern (μg/m3) 30

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

341

Chemical Quinclorac

Reason for not 

performing screen

NA

Woodrow Worksheet:

VP 0.00001 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) Developmental toxicity study in rabbits (Himalayan rabbit). (MRID# 

41063525 and 41680501)

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor NA

Aerosol NA

Inhalation study

(HEC calculated) (μg/m3)

Vapor NA

Aerosol NA

Oral study (mg/kg/day) Maternal toxicity LOAEL = 200 mg/kg/day based on decreased maternal 

body weight gain and food consumption, and increased water 

consumption. NOAEL = 70 mg/kg/day.

converted to IEC (μg/m3) 548246 μg/m3, used CF of new Zealand since no CF for himalayan

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Yes Yes Yes No

Average Hourly Flux Rate (μg/m2-s) 3.60E-03 3.60E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 548246 548246 548246

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 548.25 548.25 548.25

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

342

Chemical Quinoxyfen

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.2 × 10-5 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Multigeneration reproduction – rat (Sprague Dawley)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 20 mg/kg/day based upon a minimal decrease in F1a pup weights at 

100 mg/kg/day

converted to IEC (μg/m3) 77000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 4.19E-03 4.19E-03 4.19E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 77000 77000 77000

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 77 77 77

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

343

Chemical Quizalofop

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.1x10-7 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Chronic toxicity/Carcinogenicity study in rats – Sprague Dawley (No 

inhalation POD selected...represents chronic dietary POD).

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 0.9 mg/kg/day; LOAEL = 3.7 mg/kg/day based on increased 

incidence of centrilobular enlargement of the liver in both sexes and mild 

anemia in males.

converted to IEC (μg/m3) 3448

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 8.65E-05 8.65E-05

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 3448 3448

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 3 3

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

344

Chemical Resmethrin

Reason for not 

performing screen

There are no registered agricultural applications for resmethrin (wide-area mosquito 

abatement). No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

345

Chemical Rimsulfuron (PC 129009)

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 1 x 10-5 Pa

SOL 7.3 mg/L

Koc 55 (median) mL/g

AR 0.063 Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90 Day Toxicity-Dog (MRID 41356322)

Inhalation study

(no HEC currently calculated) 

(μg/m3)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) NOAEL= 6.25 mg/kg /day; LOAEL=125 mg/kg/day, based on 

increased urinary volume, kidney weights, and decreased osmolality. 

converted to IEC (μg/m3) 31953

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Yes

Average Hourly Flux Rate (μg/m2-s) 1.29E-03

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 31953

UF (unitless) 1000

Concentration of Concern (μg/m3) 32

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

346

Chemical Rotenone

Reason for not 

performing screen

Termination of rotenone uses that include formulations for livestock use, residential and 

homeowner uses, domestic pet uses, and all other uses, except for the piscicide uses

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

347

Chemical Saflufenacil

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.0 x 10-15 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental study in Rat -

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 5 mg/kg bw/day; LOAEL = 20 mg/kg bw/day based on 

decreased fetal bodyweight and increased skeletal variations. 

converted to IEC (μg/m3) 19157

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 3.45E-11 3.45E-11 3.45E-11

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 19157 19157 19157

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 19 19 19

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

348

Chemical Sethoxydim

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.1 x 10-5 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 28-day Rat Inhalation Study

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol NOAEL = 300000 μg/m3

; LOAEL = 2400000 μg/m3 based on increased 

liver weight, clinical chemistry (increased total serum bilirubin), and 

liver histopathology.

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 6.65E-03 6.65E-03 6.65E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 300000 300000 300000

UF (unitless) 100 100 100

Concentration of Concern (μg/m3) 3000 3000 3000

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

349

Chemical Siduron

Reason for not 

performing screen

No agricultural uses (turf uses only). No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

350

Chemical Silica and Silicates

Reason for not 

performing screen

De minimus - qualitative risk assessment. No screen performed at this time.

Woodrow Worksheet:

VP N/A Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

351

Chemical Simazine

Reason for not 

performing screen

Woodrow Worksheet:

VP 8x10-7 Pa

SOL 3.5 mg/L

Koc 120 mL/g

AR 4.8 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Pubertal assay in rats - Wistar

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 6.25 mg/kg/day; LOAEL = 12.5 mg/kg/day based on 

delayed preputial separation in male offspring after 30 days of dosing

converted to IEC (μg/m3) 23046

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 7.16E-02 4.46E-04

Application timing Spring Spring

Averaging time for Concentration 6 0.86 6

HEC or IEC (μg/m3) 23046 23046

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 23 23

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 463 918 1,306 N/A

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

352

Chemical Soap Salts

Reason for not 

performing screen

De minimus risk - qualitative risk assessment. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

353

Chemical Sodium Acifluorfen

Reason for not 

performing screen

Woodrow Worksheet:

VP <1 x 10-5 Pa at 25 C

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental rat – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 20 mg/kg/day; LOAEL = 90 mg/kg based on decreased fetal 

weight and increased incidences of dilated lateral ventricles of the 

brain

converted to IEC (μg/m3) 76628

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 3.60E-03 3.60E-03

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 76628 76628

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 77 77

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

354

Chemical Sodium Benzoate

Reason for not 

performing screen

No registered conventional pesticide uses. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

355

Chemical Sodium Bisulfite

Reason for not 

performing screen

Postharvest fumigant. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

356

Chemical Sodium Cyanamide

Reason for not 

performing screen

Sodium cyanide is registered for use as a predacide/rodenticide and as a pesticide. As a 

predacide/rodenticide, it is used as an encapsulated single dose poison to control animals that are 

vectors of communicable disease or animals that prey upon livestock or threatened or endangered 

species. Individual capsules are loaded into an ejector device which is anchored to the ground. This 

product is limited to use only by trained and certified applicators under the direct supervision of a 

government agency. 

As an insecticide, sodium cyanide is used a source of hydrocyanic gas for quarantine fumigation of 

surface pests on citrus. Currently, there are no active registrations for sodium cyanide with 

food/feed uses. However, there is one Special Local Needs (SLN) food/feed use registration for 

sodium cyanide. The SLN end-use product is a granular formulation containing 98% sodium cyanide 

as the active ingredient. Sodium cyanide is used as a source of hydrogen cyanide gas which is applied 

to citrus as a post-harvest fumigant. It is applied by professional applicators only.

No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

357

Chemical Sodium Metabisulfite

Reason for not 

performing screen

Postharvest fumigant. No screen performed at this time.

Woodrow Worksheet:

VP N/A Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

358

Chemical Spinetoram

Reason for not 

performing screen

Woodrow Worksheet:

VP 5.3x10-5 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Chronic Toxicity Study in Dogs (spinetoram)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 2.49 mg/kg/day based on arteritis and necrosis of the arterial walls 

of the epididymides in males, and the thymus, thyroid, larynx and 

urinary bladder in females at M/F 5.36/5.83 mg/kg/day

converted to IEC (μg/m3) 13000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 1.43E-02 1.43E-02 1.43E-02

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 13000 13000 13000

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 13 13 13

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

359

Chemical Spinosad

Reason for not 

performing screen

Woodrow Worksheet:

VP 3x10-8 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Chronic Toxicity Study in Dogs (spinetoram)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 2.49 mg/kg/day based on arteritis and necrosis of the arterial walls 

of the epididymides in males, and the thymus, thyroid, larynx and 

urinary bladder in females at M/F 5.36/5.83 mg/kg/day

converted to IEC (μg/m3) 13000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 2.95E-05 2.95E-05 2.95E-05

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 13000 13000 13000

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 13 13 13

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

360

Chemical Spirodiclofen

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.0 × 10-7 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Subchronic Oral Toxicity-dog

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) No NOAEL based on increased adrenal gland weight (two out of four 

animals) which corroborated with histopathology findings 

(cytoplasmic vacuoles in the Zona fasciculata of the adrenal glands) 

in females at 8.4 mg/kg/day

converted to IEC (μg/m3) 43000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 3000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 1.98E-04 1.98E-04 1.98E-04

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 43000 43000 43000

UF (unitless) 3000 3000 3000

Concentration of Concern (μg/m3) 14.3 14.3 14.3

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

361

Chemical Spiromesifen

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.0 × 10-5 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Subchronic (30-day) inhalation toxicity study in rats & 5-day 

inhalation toxicity study in rats

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol 60000 ug/m3 based on the clinical signs (tremors, clonic-tonic 

convulsions, reduced activity, bradypnea, labored breathing, 

vocalization, avoidance reaction, giddiness, piloerection, limp, 

emaciation, cyanosis, squatted posture, apathy, and salivation), 

gross pathology (dark red areas or foci in the lungs, bloated 

stomachs, and pale liver), and decreased spleen weights.

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 30

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 3.60E-03 3.60E-03

Application timing Spring Spring

Averaging time for Concentration 1 1

HEC or IEC (μg/m3) 60000 60000

UF (unitless) 30 30

Concentration of Concern (μg/m3) 2000 2000

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 0

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

362

Chemical Spirotetramat

Reason for not 

performing screen

Woodrow Worksheet:

VP 5.6 x 10-9 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Prenatal developmental toxicity (rabbit)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 10 mg/kg/day; LOAEL = 40 mg/kg/day based on late 

abortion (≥GD 22), clinical signs, impaired food and water 

consumption and body-weight loss.

converted to IEC (μg/m3) 73099

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 7.38E-06 7.38E-06 7.38E-06

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 73099 73099 73099

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 73 73 73

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

363

Chemical Spiroxamine (PC 120759)

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 1.7 x 10-2 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 28-day Inhalation Toxicity Study in Rats

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol NOAEL = 87000 ug/m3 at LOAEL = 518000 ug/m3 based on 

decreased body weights and body weight gains, increased incidences 

of clinical signs of toxicity and dermal irritation, thymic atrophy, and 

toxicity to the skin, respiratory system, and liver.

Inhalation study

(HEC calculated)

(μg/m3)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) N/A

converted to IEC (μg/m3) N/A

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 1.69

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 87000

UF (unitless) 100

Concentration of Concern (μg/m3) 870

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

364

Chemical Starlicide

Reason for not 

performing screen

Starlicide is a restricted use pesticide that is limited for use and purchase only by certified 

applicators or persons under their direct supervision. There are no registered agricultural 

uses for starlicide. Starlicide is applied by manual or mechanical broadcast of treated bait 

(e.g., grain, corn, bread crumbs) and by placement of treated bait in feeding stations (i.e., 

small piles or bait containers). Agency also determined that there was low potential for 

exposure based on starlicide’s restricted use designation, registered use patterns resulting 

in limited exposure, and requirements on the label for use of personal protective 

equipment (PPE). Based on this information, an exposure assessment was not required for 

handler or post-application exposures. No screen performed at this time.

Woodrow Worksheet:

VP NA Pa

SOL NA mg/L

Koc NA mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) NA

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

NA NA NA NA

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

365

Chemical Streptomycin

Reason for not 

performing screen

Solid (vapor pressure not determined). No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

366

Chemical Strychnine

Reason for not 

performing screen

No agricultural uses (rodenticide). No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

367

Chemical Sulfentrazone

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.1 x 10-5 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Prenatal developmental toxicity – rat (Sprague-Dawley)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 10 mg/kg/day , based upon decreased mean fetal weights, and 

retardation in skeletal development evidenced by an increased 

number of litters with any variation and by decreased number of 

caudal vertebral and metacarpal ossification sites at 25 mg/kg/day

converted to IEC (μg/m3) 38000

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 3.90E-03 3.90E-03 3.90E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 38000 38000 38000

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 38 38 38

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

368

Chemical Sulfluramid

Reason for not 

performing screen

Bait stations, granular applications forestry. No screen performed at this time.

Woodrow Worksheet:

VP Pa (at 25°C)

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) 0.3 (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

369

Chemical Sulfometuron Methyl

Reason for not 

performing screen

No agricultural uses. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

370

Chemical Sulfosate

Reason for not 

performing screen

Woodrow Worksheet:

VP 5.3x10-5 Pa

SOL 4300 mg/L

Koc 345 mL/g

AR 4 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Subchronic toxicity (capsule) - dog

Subchronic toxicity (gavage) - dog

Chronic toxicity - dog

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 25 mg/kg/day; LOAEL = 50 mg/kg/day based on

salivation and emesis, clinical signs of neurotoxicity, and 

hydrocephalus.

converted to IEC (μg/m3) 127812

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

 x x

Average Hourly Flux Rate (μg/m2-s) 1.93E-03 1.43E-02

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 127812 127812

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 128 128

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

371

Chemical Sulfosulfuron

Reason for not 

performing screen

NA

Woodrow Worksheet:

VP 0.000000088 Pa

SOL 1627 mg/L

Koc 33 mL/g

AR 0.032 lb ai/A

Tox Study Information

Type and Duration (include strain of rat) No inhalation endpoint selected previously: but use this for screen:

Chronic toxicity/carcinogenicity - rat; 

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor NA

Aerosol NA

Inhalation study

(HEC calculated) (μg/m3

)

Vapor NA

Aerosol NA

Oral study (mg/kg/day) LOAEL = 244.2 mg/kg/day based on urinary tract pathology, abnormal 

crystals and urinary calculi (both sexes); mineralization in heart, lung, 

pancreas, and skeletal muscles (male). NOAEL=24 mg/kg/day

converted to IEC (μg/m3) 91,954 μg/m3

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 1000 (inhalation study required in scoping document). MOEs have 

never been calculated for inhalation.

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 2.00E-06

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 91954

UF (unitless) 1000

Concentration of Concern (μg/m3) 92

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

372

Chemical Sulfur

Reason for not 

performing screen

Qualitative Reg Review Risk Assessment, Low tox and low exposure...No screen performed 

at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

373

Chemical Sulfuryl Fluoride (078003)

Reason for not 

performing screen

Current uses are structural/commodity fumigation. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Application rate (lbs ai/A)

Duration of maximum emission (hours)

Maximum percent emitted in duration (%)

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

374

Chemical Tanol derivs.

Reason for not 

performing screen

These compounds are widely used as food additives and fragrances, are naturally occurring, 

are present in registered pesticide products at very low levels and likely to result in very low 

exposures from pesticidal uses. No screen performed at this time.

Woodrow Worksheet:

VP Pa (25 °C)

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study 0.5 (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

375

Chemical Tau-Fluvalinate

Reason for not 

performing screen

No agricultural uses. No screen performed at this time.

Woodrow Worksheet:

VP

SOL

Koc

AR

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study 0.5 (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

376

Chemical Tebuconazole

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.71 x 10-6 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental Neurotoxicity Study in Rat – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) LOAEL = 8.8 mg/kg/day based on decreases in body weights, 

absolute brain weights, brain measurements and motor activity in 

offspring

converted to IEC (μg/m3) 33716

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 300 (inhalation study available but not used)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 8.36E-04 8.36E-04 8.36E-04

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 33716 33716 33716

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 34 34 34

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

377

Chemical Tebufenozide

Reason for not 

performing screen

Woodrow Worksheet:

VP 3 x 10-6 Pa

SOL 0.83 mg/L

Koc 605 mL/g

AR 0.25 lbs ai/a Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) 90- Day Feeding Dog and 1-Year Dog Study (co-critical) Decreases in body 

weight gain in females, organ weight changes, and alterations of the 

hematological and hematopoietic systems.; Oral NOAEL = 

2.0 mg/kg/day; (Inhalation absorption rate = 100%); Occupational LOC for 

MOE = 100

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

x X X x

Average Hourly Flux Rate (μg/m2-s) 1.33E-03 1.33E-03 1.33E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 10225 10225 10225

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 10 10 10

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 0

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 0
Draft for Comment Version – March 1, 2014

378

Chemical Tebufenpyrad (090102)

Reason for not 

performing screen

Label specifies “Ornamental Crops Grown in Commercial Greenhouses”. No screen 

performed at this time.

Woodrow Worksheet:

VP < 9.7x10-6 Pa @ 20°C

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

379

Chemical Tebupirimiphos (Phostebupirim) – at-plant insecticide (probably no row crop)

Reason for not 

performing screen

Woodrow Worksheet:

VP 0.050 Pa

SOL 5500 mg/L mg/L

Koc (11-187) mL/g

AR 0.15 Lbs ai/a

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) 28-Day Inhalation – rat ; LOAEL = 1.04 mg/m3 Based on RBC ChEI;

NOAEL of 0.00016 mg/L was converted to 0.043 mg/kg/day

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X x

Average Hourly Flux Rate (μg/m2-s) 5.88E-02 4.12E+00

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 160 160

UF (unitless) 100 100

Concentration of Concern (μg/m3) 2 2

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Cole crop

Row crop > 4500 > 4500 > 4500 > 4500 > 4500 > 4500

Orchard
Draft for Comment Version – March 1, 2014

380

Chemical Tebuthiuron

Reason for not 

performing screen

No agricultural use. Herbicide used in pastureland/rangeland, non-crop industrial areas.

Woodrow Worksheet:

VP 2.7 x 10-4 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

381

Chemical Tefluthrin

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.1 x 10-3 Pa

SOL 0.02 mg/L

Koc ~ 20,000

Not mobile

mL/g

AR 0.163 lbs 

ai/a

Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) Acute Inhalation toxicity study- Rat

LOAEL = 14.9 mg/m3 based on CNS effects (decreased activity, reduced foot 

withdrawal reflex, and reduced righting reflex); NOAEL = 7.7 mg/m3

Occupational HEC= 0.54 mg/kg; 11 mg/m3

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor HEC = 11 mg/m3, 0.54 mg/kg/day (not sure vapor or aerosol)

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X x

Average Hourly Flux Rate (μg/m2-s) 4.40E+01 1.75E-01

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 11000 11000

UF (unitless) 100 100

Concentration of Concern (μg/m3) 110 110

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

382

Chemical Telone (1,3 D)

Reason for not 

performing screen

Telone (1,3 D) is a soil fumigant fumigant. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

383

Chemical Tembotrione

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.1 x 10-8 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental neurotoxicity in rat - Wistar

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) LOAEL = 0.8 mg/kg/day based on decreased acoustic startle 

response on PND 60 (males), and brain morphometric changes on 

PND 75 (males and females).

converted to IEC (μg/m3) 2950

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 1.29E-05

Application timing Spring

Averaging time for Concentration 6 0.86

HEC or IEC (μg/m3) 2950

UF (unitless) 1000

Concentration of Concern (μg/m3) 3

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

384

Chemical Tepraloxydim (PC 121005)

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.1 x 10-5 Pa at 20 oC

SOL 430 mg/L at 20 oC

Koc 8.4 mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental Toxicity – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) NOAEL= 40; LOAEL = 120 mg/kg/day based on Reduced fetal body 

weight, reduced ossification indicative of delayed maturation, and 

the occurrence of hydroureter

converted to IEC (μg/m3) 153257

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100 

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 3.90E-03

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 153257

UF (unitless) 1000

Concentration of Concern (μg/m3) 153

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

385

Chemical Terbacil

Reason for not 

performing screen

Woodrow Worksheet:

VP 6.4 x 10-5 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) 3-Gen Repro – rat (Sprague Dawley)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 2.0 mg/kg/day, based on decreased body weight at 10 mg/kg/day.

converted to IEC (μg/m3) 7700

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 1.67E-02 1.67E-02 1.67E-02

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 7700 7700 7700

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 7.7 7.7 7.7

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 147

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

386

Chemical Terbufos

Reason for not 

performing screen

Note: Granular products only. All applications soil incorporated. Screen is likely very 

conservative.

Woodrow Worksheet:

VP 4.2E-02 Pa

SOL 5.4 mg/L

Koc 500 mL/g

AR 4.35 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Subchronic inhalation study

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol NOAEL= 10 μg/m3; LOAEL = 40 μg/m3, based on RBC, plasma, and 

brain cholinesterase inhibition

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 1.65E+02

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 10

UF (unitless) 100

Concentration of Concern (μg/m3) 0.10

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

387

Chemical Tetrachlorvinphos

Reason for not 

performing screen

No agricultural uses (livestock uses). No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

388

Chemical Tetraconazole

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.6 × 10-3 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) 28-Day Inhalation toxicity – rat

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol No NOAEL, based on squamous cell metaplasia of laryngeal mucous, 

mononuclear cell infiltration, goblet hyperplasia and hypertrophy of 

nasal cavity and nasopharyngeal duct and follicular hypertrophy of 

thyroid in males at 4840 ug/m3

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 300

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 2.39E-01 2.39E-01 2.39E-01

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 4840 4840 4840

UF (unitless) 300 300 300

Concentration of Concern (μg/m3) 16 16 16

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 1,700 3,052 > 4500 > 4500 > 4500 N/A

Row crop 1,230 2,270 4,015 > 4500 > 4500 > 4500

Orchard 0 81 309 486 648 N/A
Draft for Comment Version – March 1, 2014

389

Chemical Tetradifon

Reason for not 

performing screen

No registered uses. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

390

Chemical Tetramethrin

Reason for not 

performing screen

There are no registered food-use applications for tetramethrin and no tolerances for 

specific raw agricultural commodities. Tetramethrin is used to control mosquitoes and 

other insects indoors and outdoors in residential and commercial areas. Tetramethrin is 

also applied directly to pets. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

391

Chemical TFM Lamprecide

Reason for not 

performing screen

TFM is used by the U.S. Fish and Wildlife Service (USFWS) to control the sea lamprey 

population in the Great Lakes region of the United States. No screen performed at this 

time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study 0.5 (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

392

Chemical Thiabendazole, and salts

Reason for not 

performing screen

No agricultural uses...no screen performed at this time.

Woodrow Worksheet:

VP 0.00000053 Pa

SOL mg/L

Koc mL/g

Tox Study Information

Type and Duration (include strain of rat) Subchronic oral toxicity study – rat

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor NA

Aerosol NA

Inhalation study

(HEC calculated) (μg/m3)

Vapor NA

Aerosol NA

Oral study (mg/kg/day) LOAEL = 40 mg/kg/day based on reduced body weight gains and histopathological 

changes in the bone marrow, liver and thyroid. NOAEL 10 MKD.

converted to IEC (μg/m3) 38314 μg/m3

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 300 (UFA = 3x = interspecies scaling factor, reduced from 10x for toxicokinetic 

reasons, 10 DB UF)

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

393

Chemical Thiacloprid (014019)

Reason for not 

performing screen

Woodrow Worksheet:

VP 8x10-10 Pa @ 25°C

SOL mg/L

Koc mL/g

AR Kg/ha

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol HEC = 0.005 mg/L based on increased grip strength (5000 ug/m3)

Oral study (mg/kg/day) N/A

converted to IEC (μg/m3) N/A

Duration of Animal Exposure per Day (hrs) 6 (for 5 days)

Uncertainty Factors 30

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Yes Yes

Average Hourly Flux Rate (μg/m2-s) 1.48E-06 1.48E-06

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 5000 5000

UF (unitless) 30 30

Concentration of Concern (μg/m3) 167 167

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

394

Chemical Thiamethoxam

Reason for not performing screen

Woodrow Worksheet:

VP 2.7 x 10-9 Pa (at 20°C)

6.6 x 10-9 Pa (at 25°C)

Pa

SOL 4100 (at 25°C) mg/L

Koc 48.1 mL/g

AR 0.264 Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) 2-Generation reproduction study 

LOAEL = 1.8 mg/kg/day based on increased incidence and severity of 

tubular atrophy in testes of F1 generation males.

2-Generation reproduction study 

LOAEL = 3 (males), not determined (females) mg/kg/day based on sperm 

abnormalities in F1 males. (Wistar)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) Oral study NOAEL= 1.2 mg/kg/day

converted to IEC (μg/m3) 8112

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 4.26E-07 8.45E-06 8.45E-06

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 8112 8112 8112

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 8 8 8

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

395

Chemical Thiazopyr (129100)

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.72 x 10-4 Pa

SOL 2.3 mg/L

Koc 215 mL/g

AR 2 Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Subchronic feeding study in dogs 

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL is 2 mg/kg/day based on a LOAEL of 3 mg/kg/day with 

decreased body weight gain and increased SGPT levels. Note: no 

inhalation endpoints were chosen in the original risk assessment 

(1997) because “a short- or intermediate-term risk assessment is not 

required because no endpoints, indicating potential for adverse 

effects, were identified”. Presented here is the lowest NOAEL from 

an oral study with short term duration.

converted to IEC (μg/m3) 10225

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 4.59E+00

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 10225

UF (unitless) 1000

Concentration of Concern (μg/m3) 10

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

396

Chemical Thidiazuron

Reason for not 

performing screen

Woodrow Worksheet:

VP 3.1 x 10-9 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental Toxicity - Rabbit

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 25 mg/kg/day; LOAEL = 125 mg/kg/day based on decreased

body weight gains (decreased. 70% during GD 6-29) and food 

consumption (decreased 19 during GD 6-8; 44% during GD 14-18).

converted to IEC (μg/m3) 182749

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 4.52E-06

Application timing Spring

Averaging time for Concentration 6 0.86

HEC or IEC (μg/m3) 182749

UF (unitless) 1000

Concentration of Concern (μg/m3) 183

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

397

Chemical Thiencarbazone

Reason for not 

performing screen

Woodrow Worksheet:

VP ~9 x 10-14 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Dog subchronic study 

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 159 mg/kg/day; LOAEL = 335 mg/kg/day in males and 351 

mg/kg/day in females based on urothelial effects.

converted to IEC (μg/m3) 812883

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 8.02E-10 8.02E-10

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 812883 812883

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 813 813

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

398

Chemical Thifensulfuron methyl (128845)

Reason for not 

performing screen

NA

Woodrow Worksheet:

VP 1.7 x 10-8 Pa

SOL 2240 mg/L

Koc 16.4 mL/g

AR 0.028 Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90-day rat oral study (strain unknown)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 7 mg/kg/day; LOAEL = 177 mg/kg/day, based on decreased 

body weight and body weight gain in males and females, and 

decreased spleen weights in males.

converted to IEC (μg/m3) 25811 (used CF for Wistar rats)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 5.94E-07 1.85E-05 1.85E-05

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 25811 25811 25811

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 26 26 26

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

399

Chemical Thiobencarb

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.9x10-3 Pa

SOL 30 mg/L

Koc 1380 mL/g

AR 4 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Sub-chronic neurotoxicity (rat) – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 2.0 mg/kg/day; LOAEL=20 mg/kg/d based on mean 

increased relative kidney (females) and liver (males) weights.

converted to IEC (μg/m3) 7663

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 1.40E+00

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 7663

UF (unitless) 1000

Concentration of Concern (μg/m3) 7.66

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

400

Chemical Thiodicarb

Reason for not 

performing screen

Woodrow Worksheet:

VP 9.3x10-3 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 9-day dust inhalation study in rats 

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol NOAEL could not be determined; LOAEL = 4800 μg/m3 based on 

clinical signs (pinpoint pupils and tremors) typically associated with 

cholinesterase effects.

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 300

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 1.03E+00 1.03E+00

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 4800 4800

UF (unitless) 300 300

Concentration of Concern (μg/m3) 16.00 16.00

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Row crop > 4500 > 4500 > 4500 > 4500 > 4500 > 4500

Orchard
Draft for Comment Version – March 1, 2014

401

Chemical Thiophanate-methyl (102001)

Reason for not

performing screen

Woodrow Worksheet:

VP 1.73 x 10-3 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Rabbit developmental toxicity (oral)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 10 mg/kg/day

converted to IEC (μg/m3) 73,009

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 2.55E-01 2.55E-01 2.55E-01

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 73009 73009 73009

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 73 73 73

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 337 583 832 N/A

Row crop 0 0 183 358 529 914

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

402

Chemical Tolfenpyrad

Reason for not 

performing screen

Woodrow Worksheet:

VP 4 x 10-6 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 4-Week Inhalation Toxicity, Rat

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol NOAEL = 10000 μg/m3 ; LOAEL = not determined

Decreased body weight and mortality (2/6) observed at 26000 ug/m3 in 

range-finding study. No mortality seen at the next lowest dose of 10.9

mg/m3

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 1.69E-03 1.69E-03 1.69E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 10000 10000 10000

UF (unitless) 100 100 100

Concentration of Concern (μg/m3) 100 100 100

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

403

Chemical Topramezone

Reason for not 

performing screen

Woodrow Worksheet:

VP 9.9 × 10-11 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Tox Study Information

Type and Duration (include strain of rat) Two-Generation Reproduction Study in Rats (Wistar)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) 0.4 mg/kg/day based on decreased body weight, body-weight gain in 

males, increased thyroid and kidney weights of both sexes, and 

microscopic findings in eyes, kidney and thyroid of both sexes at 4.2 

mg/kg/day

converted to IEC (μg/m3) 1500

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 (additional 10X for use of oral study)

Representative Crops Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 2.62E-07 2.62E-07

Application timing Spring Spring

Averaging time for Concentration 1 1

HEC or IEC (μg/m3) 1500 1500

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 1.5 1.5

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 0

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

404

Chemical Tralkoxydim (PC 121000)

Reason for not 

performing screen

Woodrow Worksheet:

VP 4.3 x 10-7 Pa

SOL N/A mg/L

Koc N/A mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental Oral – Alpk:AP (Wistar-derived) Rats (MRID 

43383805)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) NOAEL=30, based on delayed Ossification and skeletal 

misalignments

converted to IEC (μg/m3) 110619

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 2.67E-04

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 110619

UF (unitless) 1000

Concentration of Concern (μg/m3) 111

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

405

Chemical Triadimefon (109901)

Reason for not 

performing screen

Woodrow Worksheet:

VP 6 x 10-4 Pa

SOL mg/L

Koc mL/g

AR Kg/ha

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Subchronic neurotoxicity in rats (Wistar)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) 3.4 mg/kg/day

converted to IEC (μg/m3) 12537 μg/m3

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 1.06E-01

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 12537

UF (unitless) 1000

Concentration of Concern (μg/m3) 13

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard 0 0 0 0 119 N/A
Draft for Comment Version – March 1, 2014

406

Chemical Triallate

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.47 x 10-2 Pa 

SOL 4 mg/L

Koc 35 mL/g

AR 1.5 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Rabbit Developmental Study

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 5 mg/kg/day; LOAEL= 15 mg/kg/day based on increased 

skeletal variations in the fetus. The 7-week inhalation study was not 

used because the study was classified supplementary due to 

technical difficulties. 

converted to IEC (μg/m3) 36550

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 3.43E+02

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 36550

UF (unitless) 1000

Concentration of Concern (μg/m3) 36.55

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil > 4500 > 4500 > 4500 > 4500 > 4500 N/A

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

407

Chemical Triasulfuron

Reason for not 

performing screen

marketed as a water-dispersible granule in water-soluble packets

Woodrow Worksheet:

VP <2e-6 Pa

SOL 815 mg/L at pH 7

Koc 16 mL/g anionic form

AR 0.026 lbs 

ai/a

Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) ST: Tif:RAIF (SPF) rat developmental oral/ IT: subchronic Sprague 

Dawley rat oral

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) ST NOAEL= 100/LOAEL=300 based on decreased body weight (Bw) 

and food consumption (fc); 

IT NOAEL=10/LOAEL=500 based on decreased BW and FC (all 

mg/kg/day)

converted to IEC 

(μg/m3

)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 8.62E-05 9.52E-04

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 383142 383142

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 383 383

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 0

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

408

Chemical Tribenuron methyl (128887)

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 2.67 x 10-9 Pa at 25°C

SOL mg/L

Koc mL/g

AR Kg/ha

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental rabbit study (female New Zealand white rabbit)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) NOAEL is 20 mg/kg/day based on a LOAEL of 80 mg/kg/day with 

maternal effects consisting of decreased food consumption and 

increased abortions.

converted to IEC (μg/m3) 146199

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

N/A X X N/A

Average Hourly Flux Rate (μg/m2-s) 4.00E-06 4.00E-06

Application timing Spring Spring

Averaging time for Concentration 6 6

HEC or IEC (μg/m3) 146,199 146,199

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 146.20 146.20

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

409

Chemical Tribufos

Reason for not 

performing screen

Cotton defoliant use

Woodrow Worksheet:

VP 2.3x10-4 Pa 

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90-day inhalation study in rat

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol NOAEL = 2430000 μg/m3; LOAEL = 12000000 μg/m3, based on 

plasma and erythrocyte ChE inhibition

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 4.81E-02

Application timing Spring

Averaging time for Concentration 6 0.86

HEC or IEC (μg/m3) 2430000

UF (unitless) 100

Concentration of Concern (μg/m3) 24300.00

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

410

Chemical Trichlorfon

Reason for not 

performing screen

No agricultural uses...no screen performed at this time.

Woodrow Worksheet:

VP 0.00021 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) 21-Day Inhalation-Rat (Wistar)Inhalation (00256446)

Levels Tested: 12.7, 35.4, 103.5 mg/m3 

NOAEL was 12.7 mg/m3 and the LOAEL was 35.4 mg/m3 based on inhibition 

of plasma, RBC, and brain cholinesterase activity 

Risk Assessment states NOAEL= 0.0127 mg/Lc; c

 3.45 mg/kg/day = NOAEL(0.0127) * respiration rate of a young adult 

Wistar rat (8.46 L/hr) * study daily exposure duration (6 hr/day) ÷ body 

weight of a young adult Wistar rat (0.187 kg). 

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor NA

Aerosol 12.7 mg/m3 = 12700 μg/m3, (This is different than used in the RA)

Inhalation study

(HEC calculated) (μg/m3

)

Vapor NA

Aerosol NA

Oral study (mg/kg/day) NA

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

411

Chemical Triclopyr

Reason for not 

performing screen

NA

Woodrow Worksheet:

VP 0.0002 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) 2-Generation Reproduction Study with acid - rat

Inhalation study

(no HEC calculated) (μg/m3)

Vapor NA

Aerosol NA

Inhalation study

(HEC calculated) (μg/m3

)

Vapor NA

Aerosol NA

Oral study (mg/kg/day) LOAEL = 25 mg/kg/day based on increased incidence of F2 pups with 

exencephaly and ablepharia. NOAEL 5.0 mg/kg/day

converted to IEC (μg/m3) 19157 μg/m3

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

N/A No Yes No

Average Hourly Flux Rate (μg/m2-s) 4.29E-02

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 19157

UF (unitless) 1000

Concentration of Concern (μg/m3) 19

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 38 180

Orchard
Draft for Comment Version – March 1, 2014

412

Chemical Trifloxystrobin

Reason for not 

performing screen

N/A

Woodrow Worksheet:

VP 3.4×10-6 Pa at 25°C

SOL 0.61 mg/L at 20°C

Koc 2709 mL/g

AR 0.11 lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Two-Generation Reproduction – Sprague Dawley (no inhalation study; 

required by HASPOC: TXR#0056150)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 3.8 mg/kg/day; LOAEL = 55.3 mg/kg/day based on decreases in 

body weight, body weight gains, reduced food consumption, and 

histopathological lesions in the liver, kidneys, and spleen.

converted to IEC (μg/m3) 14559

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X X

Average Hourly Flux Rate (μg/m2-s) 2.88E-03 1.48E-03 1.48E-03 1.48E-03

Application timing Spring Spring Spring Spring

Averaging time for Concentration 6 6 6 6

HEC or IEC (μg/m3) 14559 14559 14559 14559

UF (unitless) 1000 1000 1000 1000

Concentration of Concern (μg/m3) 15 15 15 15

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

413

Chemical Trifloxysulfuron-sodium (119009)

Reason for not 

performing screen

Woodrow Worksheet:

VP <1 X 10-7 Pa

SOL 26.0 mg/L

Koc 1770 mL/g

AR 0.028 Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Developmental Toxicity Study in Rabbits

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) 100 mg/kg/day

converted to IEC (μg/m3) 730994

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 2.28E-06 7.99E-05 7.99E-05

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 730994 730994 730994

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 730.99 730.99 730.99

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 0 0 0 0 N/A

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

414

Chemical Triflumizole

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.87x10-4 Pa 

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Multi-generation Reproduction Study in Rat – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 3.5 mg/kg/day; LOAEL = 8.5 mg/kg/day based on decreased 

pup body weight, mortality, reduced litter size and increased 

incidence of hydroureter and space between the body wall and 

organs were observed at 8.5 mg/kg/day (NOAEL = 3.5 mg/kg/day). 

In addition, gestation length was increased in the dams of F1a, F2a, 

and F3a intervals at the LOAEL of 8.5 mg/kg/day (NOAEL = 3.5 

mg/kg/day).

converted to IEC (μg/m3) 13410

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X

Average Hourly Flux Rate (μg/m2-s) 4.05E-02 4.05E-02

Application timing Spring Spring

Averaging time for Concentration 6 0.86 6

HEC or IEC (μg/m3) 13410 13410

UF (unitless) 1000 1000

Concentration of Concern (μg/m3) 13.41 13.41

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 130 383 562 N/A

Row crop

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

415

Chemical Trifluralin

Reason for not 

performing screen

Woodrow Worksheet:

VP 6.1e-3 Pa

SOL 0.3 mg/L

Koc 8000 mL/g

AR 2 lbs ai/a Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) 30 day rat inhalation (Wistar)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol NOAEL=300,000 ug/m3 (81 mg/kg/day); LOAEL 1,000,000 ug/m3 

(270 mg/kg/day) based on increased methemoglobin and bilirubin in 

females and dyspnea and ruffled fur in both sexes

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6 hrs

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X X

Average Hourly Flux Rate (μg/m2-s) 1.74E+01 7.23E-01 7.23E-01 7.23E-01

Application timing Spring Spring Spring Spring

Averaging time for Concentration 6 6 6 6

HEC or IEC (μg/m3) 300000 300000 300000 300000

UF (unitless) 100 100 100 100

Concentration of Concern (μg/m3) 3000 3000 3000 3000

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil 0 1,017 2,172 3,120 3,977 N/A

Cole crop 0 0 0 0 0 N/A

Row crop 0 0 0 0 0 0

Orchard 0 0 0 0 0 N/A
Draft for Comment Version – March 1, 2014

416

Chemical Triflusulfuron

Reason for not 

performing screen

NA

Woodrow Worksheet:

VP 0.000013 Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat) 90-day oral toxicity in the rat

Inhalation study

(no HEC calculated) (μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) LOAEL = 133 mg/kg/day (males)/153 mg/kg/day (females), based on 

decreased body weight gain (observed after the first week of dosing) and 

body weight, and in females, extramedullary hematopoiesis. NOAEL = 6.56 

mg/kg/day

converted to IEC (μg/m3) 25,134 μg/m3

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 4.47E-03

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 25,134

UF (unitless) 1000

Concentration of Concern (μg/m3) 25.13

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

417

Chemical Triforine

Reason for not 

performing screen

No agricultural uses (ornamental and import only). No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

418

Chemical Trinexapac-ethyl

Reason for not 

performing screen

Woodrow Worksheet:

VP 2.16e-3 Pa

SOL 10,200 mg/L

Koc NA mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat) Rabbit developmental oral

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL 60 mg/kg/day; LOAEL 360 mg/kg/day based on decreased 

mean fetus/litter and an increased in post implantation loss converted to IEC (μg/m3

)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors 100

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 3.07E-01

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 438696

UF (unitless) 1000

Concentration of Concern (μg/m3) 439

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard
Draft for Comment Version – March 1, 2014

419

Chemical Triphenyltin hydroxide (TPTH)

Reason for not 

performing screen

Woodrow Worksheet:

VP < 1.3x10-5 Pa

SOL mg/L

Koc? mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) 90-day subchronic inhalation study with adult SPF-Wistar rats

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor NOAEL = 340 μg/m3; LOAEL = 20000 μg/m3 based on death and 

respiratory irritation and edema.

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000 

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X X X

Average Hourly Flux Rate (μg/m2-s) 4.47E-03 4.47E-03 4.47E-03

Application timing Spring Spring Spring

Averaging time for Concentration 6 6 6

HEC or IEC (μg/m3) 340 340 340

UF (unitless) 1000 1000 1000

Concentration of Concern (μg/m3) 0.34 0.34 0.34

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 1,425 2,612 > 4500 > 4500 > 4500 N/A

Row crop 1,021 1,931 3,454 > 4500 > 4500 > 4500

Orchard 0 0 228 379 518 N/A
Draft for Comment Version – March 1, 2014

420

Chemical Triticonazole (125620)

Reason for not 

performing screen

No agricultural uses other than seed treatment. No screen performed at this time.

Woodrow Worksheet:

VP Pa at 25°C

SOL mg/L at 20°C

Koc mL/g at 25°C

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

421

Chemical Undecylenic Acid

Reason for not 

performing screen

No food uses- use in pet shampoos and sprays. Based on the low toxicity of undecylenic 

acid and its use as a pharmaceutical drug administered in higher doses than would result 

from any pesticide exposures, a quantitative human health risk assessment is not required 

under registration review for the existing uses of undecylenic acid. No screen performed at 

this time.

Woodrow Worksheet:

VP Pa 

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

422

Chemical Uniconazole

Reason for not 

performing screen

Woodrow Worksheet:

VP 1.3 x 10-8 Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Prenatal Developmental Toxicity in rat – Sprague Dawley

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day) NOAEL = 5 mg/kg/day; LOAEL = 25 mg/kg/day based on increased 

incidence of 14th rib

converted to IEC (μg/m3) 19157

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 1.48E-05

Application timing Spring

Averaging time for Concentration 6 0.86

HEC or IEC (μg/m3) 19157

UF (unitless) 1000

Concentration of Concern (μg/m3) 19

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop 0 0 0 0 0 N/A

Row crop

Orchard
Draft for Comment Version – March 1, 2014

423

Chemical Urea

Reason for not 

performing screen

Qualitative Reg Review Risk Assessment, 2005 TRED Qualitative, Low tox... No screen 

performed at this time. 

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Lb ai/A

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

424

Chemical Vinclozolin

Reason for not 

performing screen

No agricultural uses currently registered. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

425

Chemical Warfarin

Reason for not 

performing screen

Rodenticide/ no agricultural uses

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR Kg/ha

R

Flux (ug/m2-s) Plant Soil

Woodrow

90th

Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC calculated) (μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated) (μg/m3

)

Vapor

Aerosol

Oral study converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Duration of maximum emission (hours)

Maximum percent emitted in duration (%)

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

426

Chemical Xylene

Reason for not 

performing screen

Aquatic herbicide use only. No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3

)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

427

Chemical Zinc Phosphide

Reason for not 

performing screen

Inhalation endpoints for zinc phosphide have not been selected and/or

established and therefore quantitative occupational assessment has not been conducted. 

No screen performed at this time.

Woodrow Worksheet:

VP Pa

SOL mg/L

Koc mL/g

AR lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat)

Inhalation study

(no HEC currently calculated) 

(μg/m3)

Vapor

Aerosol

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor

Aerosol

Oral study (mg/kg/day)

converted to IEC (μg/m3)

Duration of Animal Exposure per Day (hrs)

Uncertainty Factors

Representative Crops

Bare Ground Cole/Cotton Row Orchard

Average Hourly Flux Rate (μg/m2-s)

Application timing

Averaging time for Concentration

HEC or IEC (μg/m3)

UF (unitless)

Concentration of Concern (μg/m3)

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop

Orchard
Draft for Comment Version – March 1, 2014

428

Chemical Zoxamide (PC 101702)

Reason for not 

performing screen

Woodrow Worksheet:

VP <1.33 x 

10-5

Pa

SOL N/A mg/L

Koc N/A mL/g

AR Lb ai/A

Inhalation Assessment Tox Study Information

Type and Duration (include strain of rat) Chronic Toxicity Study – Dogs (MRID 44731817)

Inhalation study

(no HEC currently calculated) 

(μg/m3)

Vapor N/A

Aerosol N/A

Inhalation study

(HEC calculated)

(μg/m3

)

Vapor N/A

Aerosol N/A

Oral study (mg/kg/day) NOAEL= 48 mg/kg/day; LOAEL = 255/277 mg/kg/day based on body 

weight changes, increases in liver and thyroid weights, and increases 

in alkaline phosphatase. (D296194, D296209)

converted to IEC (μg/m3) 245399

Duration of Animal Exposure per Day (hrs) 6

Uncertainty Factors 1000

Representative Crops

Bare Ground Cole/Cotton Row Orchard

X

Average Hourly Flux Rate (μg/m2-s) 4.56E-03

Application timing Spring

Averaging time for Concentration 6

HEC or IEC (μg/m3) 245339

UF (unitless) 1000

Concentration of Concern (μg/m3) 245

Crop Type

Field Size (acres)

Distance to COC (m)

10 20 40 60 80 120

Bare soil

Cole crop

Row crop 0 0 0 0 0 0

Orchard