#### § 558.76 Bacitracin methylenedisalicylate.

(a) *Specifications.*

(1) Type A medicated articles containing feed grade bacitracin methylenedisalicylate equivalent to 10, 25, 30, 40, 50, 60, or 75 grams bacitracin per pound.

(2) Type A medicated article containing feed grade bacitracin methylenedisalicylate equivalent to 50 grams bacitracin per pound.

(b) *Sponsors.* See sponsors in [§ 510.600(c) of this chapter](/on/2024-09-23/title-21/section-510.600#p-510.600(c)) as follows:

(1) No. 054771 for use of products in [paragraph (a)(1)](/on/2024-09-23/title-21/section-558.76#p-558.76(a)(1)) of this section as in [paragraph (d)](/on/2024-09-23/title-21/section-558.76#p-558.76(d)) of this section.

(2) No. 069254 for use of product in [paragraph (a)(2)](/on/2024-09-23/title-21/section-558.76#p-558.76(a)(2)) of this section as in [paragraph (d)](/on/2024-09-23/title-21/section-558.76#p-558.76(d)) of this section.

(c) *Related tolerances.* See [§ 556.70 of this chapter](/on/2024-09-23/title-21/section-556.70).

(d) *Conditions of use* —

(1) *Chickens* —

| Bacitracin in grams per ton | Indications for use | Limitations | Sponsor |
| --- | --- | --- | --- |
| (i) 4 to 50 | Broiler and replacement chickens: For increased rate of weight gain and improved feed efficiency | Feed continuously as sole ration | 054771 069254 |
| (ii) 10 to 25 | Laying hens: For increased egg production and improved feed efficiency | Feed continuously as sole ration for the first 7 months of egg production | 054771 |
| (iii) 50 | Broiler and replacement chickens: As an aid in the prevention of necrotic enteritis caused or complicated by *Clostridium* spp. or other organisms susceptible to bacitracin | Feed continuously as sole ration | 054771 |
| (iv) 50 | Broiler and replacement chickens: For the prevention of mortality caused by necrotic enteritis associated with *Clostridium perfringens* | Feed as the sole ration for 28 to 35 days, starting from the time chicks are placed for brooding | 069254 |
| (v) 100 to 200 | Broiler and replacement chickens: As an aid in the control of necrotic enteritis caused or complicated by *Clostridium* spp. or other organisms susceptible to bacitracin | Feed continuously as sole ration. Start at first clinical signs of disease. Vary dosage based on severity of infection. Administer continuously for 5 to 7 days or as long as clinical signs persist, then reduce medication to prevention level (50 grams/ton) | 054771 |

(2) *Turkeys* —

| Bacitracin in grams per ton | Indications for use | Limitations | Sponsor |
| --- | --- | --- | --- |
| (i) 4 to 50 | Growing turkeys: For increased rate of weight gain and improved feed efficiency | Feed continuously as sole ration | 054771 069254 |
| (ii) 200 | Growing turkeys: As an aid in the control of transmissible enteritis complicated by organisms susceptible to bacitracin methylenedisalicylate | Feed continuously as the sole ration | 054771 |

(3) *Swine* —

| Bacitracin in grams per ton | Indications for use | Limitations | Sponsor |
| --- | --- | --- | --- |
| (i) 10 to 30 | Growing and finishing swine: For increased rate of weight gain and improved feed efficiency | | 054771 |
| (ii) 250 | Growing and finishing swine: For control of swine dysentery (bloody scours) associated with *Brachyspira hyodysenteriae* in pigs up to 250 lbs body weight | Feed as the sole ration. Feed 250 grams per ton of complete feed on premises with a history of swine dysentery, but where signs of the disease have not yet occurred or following an approved treatment of the disease condition. Diagnosis should be confirmed by a veterinarian a when results are not satisfactory | 054771 |
| (iii) 250 | Pregnant sows: For control of clostridial enteritis caused by *Clostridium perfringens* in suckling piglets | As the sole ration. Feed to sows from 14 days before through 21 days after farrowing on premises with a history of clostridial scours. Diagnosis should be confirmed by a veterinarian when results are not satisfactory | 054771 |

(4) *Cattle* —

| Bacitracin amount | Indications for use | Limitations | Sponsor |
| --- | --- | --- | --- |
| (i) 70 mg per head per day | Beef steers and heifers fed in confinement for slaughter: For reduction in the number of liver condemnations due to abscesses | Administer continuously throughout the feeding period | 054771 069254 |
| (ii) 250 mg per head per day | Beef steers and heifers fed in confinement for slaughter: For reduction in the number of liver condemnations due to abscesses | Administer continuously for 5 days then discontinue for subsequent 25 days, repeat the pattern during the feeding period | 054771 069254 |

(5) *Game birds* —

| Bacitracin in grams per ton | Indications for use | Limitations | Sponsor |
| --- | --- | --- | --- |
| (i) 4 to 50 | Growing pheasants: For increased rate of weight gain and improved feed efficiency | Feed continuously as sole ration | 054771 069254 |
| (ii) 5 to 20 | Growing quail: For increased rate of weight gain and improved feed efficiency in quail not over 5 weeks of age | Feed continuously as sole ration to quail not over 5 weeks of age | 054771 069254 |
| (iii) 200 | Growing quail: For the prevention of ulcerative enteritis in growing quail due to *Clostridium colinum* susceptible to bacitracin methylenedisalicylate | Feed continuously as the sole ration | 054771 |

(6) Bacitracin methylenedisalicylate may also be used in combination with:

(i) Amprolium as in [§ 558.55](/on/2024-09-23/title-21/section-558.55).

(ii) Amprolium and ethopabate as in [§ 558.58](/on/2024-09-23/title-21/section-558.58).

(iii) Chlortetracycline as in [§ 558.128](/on/2024-09-23/title-21/section-558.128).

(iv) Clopidol as in [§ 558.175](/on/2024-09-23/title-21/section-558.175).

(v) Decoquinate as in [§ 558.195](/on/2024-09-23/title-21/section-558.195).

(vi) Diclazuril as in [§ 558.198](/on/2024-09-23/title-21/section-558.198).

(vii) Fenbendazole as in [§ 558.258](/on/2024-09-23/title-21/section-558.258).

(viii) Halofuginone as in [§ 558.265](/on/2024-09-23/title-21/section-558.265).

(ix) Ivermectin as in [§ 558.300](/on/2024-09-23/title-21/section-558.300).

(x) Lasalocid as in [§ 558.311](/on/2024-09-23/title-21/section-558.311).

(xi) Monensin as in [§ 558.355](/on/2024-09-23/title-21/section-558.355).

(xii) Narasin as in [§ 558.363](/on/2024-09-23/title-21/section-558.363).

(xiii) Narasin and nicarbazin as in [§ 558.364](/on/2024-09-23/title-21/section-558.364).

(xiv) Nicarbazin as in [§ 558.366](/on/2024-09-23/title-21/section-558.366).

(xv) Robenidine as in [§ 558.515](/on/2024-09-23/title-21/section-558.515).

(xvi) Salinomycin as in [§ 558.550](/on/2024-09-23/title-21/section-558.550).

(xvii) Semduramicin as in [§ 558.555](/on/2024-09-23/title-21/section-558.555).

(xviii) Zoalene as in [§ 558.680](/on/2024-09-23/title-21/section-558.680).

[[41 FR 10993](https://www.federalregister.gov/citation/41-FR-10993), Mar. 15, 1976]

###### Editorial Note

#### Editorial Note

For Federal Register citations affecting [§ 558.76](/on/2024-09-23/title-21/section-558.76), see the List of CFR Sections Affected, which appears in the Finding Aids section of the printed volume and at *[www.govinfo.gov](http://www.govinfo.gov).*