STANDARD REVIEW EXPOSURE REPO RT- NANOMATERIAL Page 1 of 5

P-09-0054 Final Date 1/26/09

Assessor: C. Cinalli

Production Volume:

USE:

OTHER USES:STANDARD REVIEW EXPOSURE REPO RT- NANOMATERIAL Page 2 of 5

P-09-0054 Final Date 1/26/09

Chemical Name: [5,6] Fullerene-C60-Ih

Fate Assessment :

Due to the novel nature of nanomaterials, it is not possible at this time to make

assumptions about their behavior in the envir onment without the collection of physicochemical

(p-chem) and fate data. The p-chem properties which seem most important for fate assessment

are: surface reactivity, aggregat ion/agglomeration, physical form, particle size distribution,

surface area solubility, dispersabil ity, shape, adsorption tendency and surface charge porosity.

These p-chem properties are novel to nanomater ials and are not estimated by our current

collection of fate models, EPI Suite. Therefore, specific data on the ac tual behavior of the

nanomaterial in waste water treatment plants (e.g., biodegradation, sorption to sludge,

volatilization, etc.) and drinking water treatment plants (e.g., eff ect of chlorination, oxygenation,

etc.) are needed to determine removal rates. Ad ditionally, data are needed to assess the potential

for ground water migration. Testing methods typical ly used for these parameters (e.g., ready

biodegradation test, porous pot, etc.) may or may not apply. If the amount of the nanomaterial

released is of concern, EAB recommends that th e submitter evaluate the current OPPT guidelines

for fate testing and then submit fate testing pr otocols based on their specific knowledge of the

nanomaterial to the EAB’s fate experts for their revi ew prior to the actual testing. It is possible

that after several nanomaterials have gone through p-chem and fate testing, that models in EPI

Suite could be validated for use, or, more likely, a new fate mode l or models could be developed

to estimate the fate of a new na nomaterial in the environment.

General Population and Environmental ExposureSTANDARD REVIEW EXPOSURE REPO RT- NANOMATERIAL Page 3 of 5

P-09-0054 Final Date 1/26/09

A qualitative evaluation of the releases estimated by CEB indicates that there is some

potential for exposure to the genera l population and the environment from landfill and/or

incineration releases as well as fugitive air releases . Due to the novel nature of this PMN

chemical it is not possible to quantify the e xposure from these release scenarios. Human

inhalation, ingestion and dermal exposure may result from the landfill, incineration and

fugitive releases.

It is not possible at this time to quantify th e exposure due to the uncertainty surrounding the

environmental fate of nanomaterial s in water, air, inci neration and landfill, and the uncertainty of

applying existing fate and air disp ersion models that were devel oped based on chemicals that are

not nanomaterials. It is recommended that the submitter work with EPA engineers, fate experts

and exposure assessors to develop chemical -specific testing for this PMN chemical.STANDARD REVIEW EXPOSURE REPO RT- NANOMATERIAL Page 4 of 5

P-09-0054 Final Date 1/26/09

Environmental Releases from the Engineering Report

1STANDARD REVIEW EXPOSURE REPO RT- NANOMATERIAL Page 5 of 5

P-09-0054 Final Date 1/26/09