Exhibit 10.2

    

    
       

      

      INVESTMENT MANAGEMENT TRUST AGREEMENT

       

      This Investment Management Trust Agreement (this “Agreement”)
        is made effective as of August 11, 2020 by and between ARYA Sciences Acquisition Corp III, a Cayman Islands exempted company (the “Company”),
        and Continental Stock Transfer & Trust Company, a New York corporation (the “Trustee”).

       

      WHEREAS, the Company’s registration statements on Form S-1, File Nos. 333-239986 and 333-241828 (the “Registration Statements”) and prospectus (the “Prospectus”) for the initial
        public offering of the Company’s Class A ordinary shares, par value $0.0001 per share (“Ordinary Shares”) (such initial public offering
        hereinafter referred to as the “Offering”), has been declared effective as of the date hereof by the U.S. Securities and Exchange
        Commission; and

       

      WHEREAS, the Company has entered into an Underwriting Agreement (the “Underwriting Agreement”) with Jefferies LLC and Goldman Sachs & Co. LLC, as representatives (the “Representatives”)
        to the several underwriters (the “Underwriters”) named therein; and

       

      WHEREAS, as described in the Prospectus, $130,000,000 of the gross proceeds of the Offering and sale of the Sponsor Shares (as defined in the
        Underwriting Agreement) (or $149,500,000 if the Underwriters’ option to purchase additional Ordinary Shares is exercised in full) will be delivered to the Trustee to be deposited and held in a segregated trust account located at all times in the
        United States (the “Trust Account”) for the benefit of the Company and the holders of the Ordinary Shares issued in the Offering as
        hereinafter provided (the amount to be delivered to the Trustee (and any interest subsequently earned thereon) is referred to herein as the “Property,”
        the shareholders for whose benefit the Trustee shall hold the Property will be referred to as the “Public Shareholders,” and the Public
        Shareholders and the Company will be referred to together as the “Beneficiaries”); and

       

      WHEREAS, pursuant to the Underwriting Agreement, a portion of the Property equal to $4,550,000, or $5,232,500 if the Underwriters’ option to purchase
        additional Ordinary Shares is exercised in full, is attributable to deferred underwriting discounts and commissions that will be payable by the Company to the Underwriter upon the consummation of the Business Combination (as defined below) (the “Deferred Discount”); and

       

      WHEREAS, the Company and the Trustee desire to enter into this Agreement to set forth the terms and conditions pursuant to which the Trustee shall hold
        the Property.

       

      NOW THEREFORE, IT IS AGREED:

       

      1.           Agreements
          and Covenants of Trustee. The Trustee hereby agrees and covenants to:

       

      (a)          Hold the Property in trust for the
          Beneficiaries in accordance with the terms of this Agreement in the Trust Account established by the Trustee located in the United States at J.P. Morgan Chase Bank, N.A. (or at another U.S. chartered commercial bank with consolidated assets of
          $100 billion or more) in the United States, maintained by Trustee and at a brokerage institution selected by the Trustee that is reasonably satisfactory to the Company;

       

      
        
          


      

      
      (b)           Manage, supervise and administer
          the Trust Account subject to the terms and conditions set forth herein;

       

      (c)          In a timely manner, upon the
          written instruction of the Company, invest and reinvest the Property in United States government securities within the meaning of Section 2(a)(16) of the Investment Company Act of 1940, as amended, having a maturity of 185 days or less, or in
          money market funds meeting the conditions of paragraphs (d)(1), (d)(2), (d)(3) and (d)(4) of Rule 2a-7 promulgated under the Investment Company Act of 1940, as amended (or any successor rule), which invest only in direct U.S. government treasury
          obligations, as determined by the Company; the Trustee may not invest in any other securities or assets, it being understood that the Trust Account will earn no interest while account funds are uninvested awaiting the Company’s instructions
          hereunder and the Trustee may earn bank credits or other consideration;

       

      (d)         Collect and receive, when due, all
          principal, interest or other income arising from the Property, which shall become part of the “Property,” as such term is used herein;

       

      (e)        Promptly notify the Company and the
          Representatives of all communications received by the Trustee with respect to any Property requiring action by the Company;

       

      (f)          Supply any necessary information or
          documents as may be requested by the Company (or its authorized agents) in connection with the Company’s preparation of the tax returns relating to assets held in the Trust Account;

       

      (g)          Participate in any plan or
          proceeding for protecting or enforcing any right or interest arising from the Property if, as and when instructed by the Company to do so;

       

      (h)         Render to the Company monthly
          written statements of the activities of, and amounts in, the Trust Account reflecting all receipts and disbursements of the Trust Account;

       

      (i)            Commence liquidation of the
          Trust Account only after and promptly following (x) receipt of, and only in accordance with, the terms of a letter from the Company (“Termination
            Letter”) in a form substantially similar to that attached hereto as either Exhibit A or Exhibit B, as applicable, signed on behalf of the Company by its Chief Executive Officer, Chief Financial Officer or other authorized officer of the Company, and complete the liquidation of the
          Trust Account and distribute the Property in the Trust Account, including interest earned on the funds held in the Trust Account and not previously released to the Company to pay its income taxes, if any, (less up to $100,000 of interest to pay
          dissolution expenses), only as directed in the Termination Letter and the other documents referred to therein, or (y) upon the date which is the later of (1) 24 months after the closing of the Offering and (2) such later date as may be approved
          by the Company’s shareholders in accordance with the Company’s amended and restated memorandum and articles of association, if a Termination Letter has not been received by the Trustee prior to such date, in which case the Trust Account shall be
          liquidated in accordance with the procedures set forth in the Termination Letter attached as Exhibit B and the Property in the Trust Account,
          including interest earned on the funds held in the Trust Account and not previously released to the Company to pay its income taxes, if any, (less up to $100,000 of interest to pay dissolution expenses), shall be distributed to the Public
          Shareholders of record as of such date. It is acknowledged and agreed that there should be no reduction in the principal amount per share initially deposited in the Trust Account;

       

      
        2

        
          


      

      (j)           Upon written request from the
          Company, which may be given from time to time in a form substantially similar to that attached hereto as Exhibit C (a “Tax Payment Withdrawal Instruction”), withdraw from the Trust Account and distribute to the Company the amount of interest earned on the Property requested by the
          Company to cover any tax obligation owed by the Company as a result of assets of the Company or interest or other income earned on the Property, which amount shall be delivered directly to the Company by electronic funds transfer or other method
          of prompt payment, and the Company shall forward such payment to the relevant taxing authority, so long as there is no reduction in the principal amount initially deposited in the Trust Account; provided, however, that to the extent there is not sufficient cash in the Trust Account to pay such tax obligation, the Trustee shall
          liquidate such assets held in the Trust Account as shall be designated by the Company in writing to make such distribution, so long as there is no reduction in the principal per share amount initially deposited in the Trust Account (it being
          acknowledged and agreed that any such amount in excess of interest income earned on the Property shall not be payable from the Trust Account). The written request of the Company referenced above shall constitute presumptive evidence that the
          Company is entitled to said funds, and the Trustee shall have no responsibility to look beyond said request;

       

      (k)          Upon written request from the
          Company, which may be given from time to time in a form substantially similar to that attached hereto as Exhibit D (a “Shareholder Redemption Withdrawal Instruction”), the Trustee shall distribute to the remitting brokers on behalf of Public Shareholders redeeming Ordinary Shares the
          amount required to pay redeemed Ordinary Shares from Public Shareholders pursuant to the Company’s amended and restated memorandum and articles of association; and

       

      (l)            Not make any withdrawals or
          distributions from the Trust Account other than pursuant to Section 1(i), (j) or (k) above.

       

      2.            Agreements
          and Covenants of the Company. The Company hereby agrees and covenants to:

       

      (a)          Give all instructions to the
          Trustee hereunder in writing, signed by the Company’s Chief Executive Officer, Chief Financial Officer or other authorized officer of the Company. In addition, except with respect to its duties under Sections 1(i), (j) or (k) hereof, the Trustee shall be
          entitled to rely on, and shall be protected in relying on, any verbal or telephonic advice or instruction which it, in good faith and with reasonable care, believes to be given by any one of the persons authorized above to give written
          instructions, provided that the Company shall promptly confirm such instructions in writing;

       

      
        3

        
          


      

      (b)         Subject to Section 4 hereof, hold the Trustee harmless and indemnify the Trustee from and against any and all reasonable and documented expenses, including reasonable counsel fees and disbursements, or
          losses suffered by the Trustee in connection with any action taken by it hereunder and in connection with any action, suit or other proceeding brought against the Trustee involving any claim, or in connection with any claim or demand, which in
          any way arises out of or relates to this Agreement, the services of the Trustee hereunder, or the Property or any interest earned on the Property, except for expenses and losses resulting from the Trustee’s gross negligence, fraud or willful
          misconduct. Promptly after the receipt by the Trustee of notice of demand or claim or the commencement of any action, suit or proceeding, pursuant to which the Trustee intends to seek indemnification under this Section 2(b), it shall notify the Company in writing of such claim (hereinafter referred to as the “Indemnified Claim”). The Trustee shall have the right to conduct and manage the defense against such Indemnified Claim; provided that the Trustee
          shall obtain the consent of the Company with respect to the selection of counsel, which consent shall not be unreasonably withheld. The Trustee may not agree to settle any Indemnified Claim without the prior written consent of the Company, which
          such consent shall not be unreasonably withheld. The Company may participate in such action with its own counsel;

       

      (c)         Pay the Trustee the fees set forth
          on Schedule A hereto, including an initial acceptance fee, annual administration fee, and transaction processing fee which fees shall be subject to modification by the parties from time to time. It is expressly understood that the Property shall
          not be used to pay such fees unless and until it is distributed to the Company pursuant to Sections 1(i) through 1(k) hereof. The Company shall pay the Trustee the initial acceptance fee and the first annual administration fee at the consummation of the Offering. The Trustee shall refund to the Company the annual administration fee
          (on a pro rata basis) with respect to any period after the liquidation of the Trust Account. The Company shall not be responsible for any other fees or charges of the Trustee except as set forth in this Section 2(c) and as may be provided in Section 2(b) hereof;

       

      (d)        In connection with any vote of the
          Company’s shareholders regarding a merger, share exchange, asset acquisition, share purchase, reorganization or similar business combination involving the Company and one or more businesses (the “Business Combination”), provide to the Trustee an affidavit or certificate of the inspector of elections for the shareholder meeting verifying the vote of such shareholders regarding
          such Business Combination;

       

      (e)         Provide the Representatives with a
          copy of any Termination Letter(s) and/or any other correspondence that is sent to the Trustee with respect to any proposed withdrawal from the Trust Account promptly after it issues the same;

       

      (f)         Unless otherwise agreed between the
          Company and the Representatives, ensure that any Instruction Letter (as defined in Exhibit A) delivered in connection with a Termination Letter in
          the form of Exhibit A expressly provides that the Deferred Discount is paid directly to the account or accounts directed by the Representatives on
          behalf of the Underwriters prior to any transfer of the funds held in the Trust Account to the Company or any other person;

       

      (g)          Instruct the Trustee to make only
          those distributions that are permitted under this Agreement, and refrain from instructing the Trustee to make any distributions that are not permitted under this Agreement;

       

      
        4

        
          


      

      (h)          If the Company seeks to amend any
          provisions of its amended and restated memorandum and articles of association (A) to modify the substance or timing of the Company’s obligation to provide holders of the Ordinary Shares the right to have their shares redeemed in connection with
          the Company’s initial Business Combination or to redeem 100% of the Ordinary Shares if the Company does not complete its initial Business Combination within the time period set forth therein or (B) with respect to any other provision relating to
          the rights of holders of the Ordinary Shares (in each case, an “Amendment”), the Company will provide the Trustee with a letter (an “Amendment Notification Letter”) in the form of Exhibit
              D providing instructions for the distribution of funds to Public Shareholders who exercise their redemption option and properly tender their shares in connection with such Amendment; and

       

      (i)          Within five (5) business days after
          the Underwriters exercise their option to purchase additional Ordinary Shares (or any unexercised portion thereof) or such option to purchase additional Ordinary Shares expires, provide the Trustee with a notice in writing of the total amount of
          the Deferred Discount.

       

      3.            Limitations
          of Liability. The Trustee shall have no responsibility or liability to:

       

      (a)        Imply obligations, perform duties,
          inquire or otherwise be subject to the provisions of any agreement or document other than this Agreement and that which is expressly set forth herein;

       

      (b)           Take any action with respect to
          the Property, other than as directed in Section 1 hereof, and the Trustee shall have no liability to any third party except for liability arising out of the Trustee’s
          gross negligence, fraud or willful misconduct;

       

      (c)          Institute any proceeding for the
          collection of any principal and income arising from, or institute, appear in or defend any proceeding of any kind with respect to, any of the Property unless and until it shall have received written instructions from the Company given as provided
          herein to do so and the Company shall have advanced or guaranteed to it funds sufficient to pay any expenses incident thereto;

       

      (d)           Change the investment of any
          Property, other than in compliance with Section 1 hereof;

       

      (e)           Refund any depreciation in
          principal of any Property;

       

      (f)         Assume that the authority of any
          person designated by the Company to give instructions hereunder shall not be continuing unless provided otherwise in such designation, or unless the Company shall have delivered a written revocation of such authority to the Trustee;

       

      (g)          The other parties hereto or to
          anyone else for any action taken or omitted by it, or any action suffered by it to be taken or omitted, in good faith and in the Trustee’s best judgment, except for the Trustee’s gross negligence, fraud or willful misconduct. The Trustee may rely
          conclusively and shall be protected in acting upon any order, notice, demand, certificate, opinion or advice of counsel (including counsel chosen by the Trustee with written notification to the Company, which counsel may be the Company’s
          counsel), statement, instrument, report or other paper or document (not only as to its due execution and the validity and effectiveness of its provisions, but also as to the truth and acceptability of any information therein contained) which the
          Trustee believes, in good faith and with reasonable care, to be genuine and to be signed or presented by the proper person or persons. The Trustee shall not be bound by any notice or demand, or any waiver, modification, termination or rescission
          of this Agreement or any of the terms hereof, unless evidenced by a written instrument delivered to the Trustee, signed by the proper party or parties and, if the duties or rights of the Trustee are affected, unless it shall give its prior
          written consent thereto;

       

      
        5

        
          


      

      (h)           Verify the accuracy of the
          information contained in the Registration Statements;

       

      (i)          Provide any assurance that any
          Business Combination entered into by the Company or any other action taken by the Company is as contemplated by the Registration Statements;

       

      (j)          File information returns with
          respect to the Trust Account with any local, state or federal taxing authority or provide periodic written statements to the Company documenting the taxes payable by the Company, if any, relating to any interest income earned on the Property;

       

      (k)          Prepare, execute and file tax
          reports, income or other tax returns and pay any taxes with respect to any income generated by, and activities relating to, the Trust Account, regardless of whether such tax is payable by the Trust Account or the Company, including, but not
          limited to, income tax obligations, except pursuant to Section 1(j) hereof; or

       

      (l)          Verify calculations, qualify or
          otherwise approve the Company’s written requests for distributions pursuant to Sections 1(i), 1(j)
          or 1(k) hereof.

       

      4.          Trust
          Account Waiver. The Trustee has no right of set-off or any right, title, interest or claim of any kind (“Claim”) to, or to any
        monies in, the Trust Account, and hereby irrevocably waives any Claim to, or to any monies in, the Trust Account that it may have now or in the future. In the event the Trustee has any Claim against the Company under this Agreement, including,
        without limitation, under Section 2(b) or Section 2(c) hereof, the Trustee shall pursue such
        Claim solely against the Company and its assets outside the Trust Account and not against the Property or any monies in the Trust Account.

       

      5.            Termination.
        This Agreement shall terminate as follows:

       

      (a)          If the Trustee gives written notice
          to the Company that it desires to resign under this Agreement, the Company shall use its reasonable efforts to locate a successor trustee, pending which the Trustee shall continue to act in accordance with this Agreement. At such time that the
          Company notifies the Trustee that a successor trustee has been appointed by the Company and has agreed to become subject to the terms of this Agreement, the Trustee shall transfer the management of the Trust Account to the successor trustee,
          including but not limited to the transfer of copies of the reports and statements relating to the Trust Account, whereupon this Agreement shall terminate; provided, however, that in the event that the Company does not locate a successor trustee within ninety (90) days of receipt of the resignation notice from the Trustee, the Trustee
          may submit an application to have the Property deposited with any court in the State of New York or with the United States District Court for the Southern District of New York and upon such deposit, the Trustee shall be immune from any liability
          whatsoever; or

       

      
        6

        
          


      

      (b)          At such time that the Trustee has
          completed the liquidation of the Trust Account and its obligations in accordance with the provisions of Section 1(i) hereof and distributed the Property in accordance
          with the provisions of the Termination Letter, this Agreement shall terminate except with respect to Section 2(b).

       

      6.            Miscellaneous.

       

      (a)          The Company and the Trustee each
          acknowledge that the Trustee will follow the security procedures set forth herein with respect to funds transferred from the Trust Account. The Company and the Trustee will each restrict access to confidential information relating to such
          security procedures to authorized persons. Each party must notify the other party immediately if it has reason to believe unauthorized persons may have obtained access to such confidential information, or of any change in its authorized
          personnel. In executing funds transfers, the Trustee shall rely upon all information supplied to it by the Company, including, account names, account numbers, and all other identifying information relating to a Beneficiary, Beneficiary’s bank or
          intermediary bank. Except for any liability arising out of the Trustee’s gross negligence, fraud or willful misconduct, the Trustee shall not be liable for any loss, liability or expense resulting from any error in the information or transmission
          of the funds.

       

      (b)          This Agreement shall be governed by
          and construed and enforced in accordance with the laws of the State of New York, without giving effect to conflicts of law principles that would result in the application of the substantive laws of another jurisdiction. This Agreement may be
          executed in several original or facsimile counterparts, each one of which shall constitute an original, and together shall constitute but one instrument.

       

      (c)           This Agreement contains the
          entire agreement and understanding of the parties hereto with respect to the subject matter hereof. Except for Section 1(i), 1(j) and 1(k) hereof (which sections may not be modified, amended or deleted without the affirmative vote of sixty-five percent
          (65%) of the then outstanding Ordinary Shares and Class B ordinary shares, par value $0.0001 per share, of the Company, voting together as a single class; provided that
          no such amendment will affect any Public Shareholder who has properly elected to redeem his or her Ordinary Shares in connection with a shareholder vote for an Amendment, this Agreement or any provision hereof may only be changed, amended or
          modified (other than to correct a typographical error) by a writing signed by each of the parties hereto.

       

      (d)           The parties hereto consent to the
          jurisdiction and venue of any state or federal court located in the City of New York, State of New York, for purposes of resolving any disputes hereunder. AS TO ANY CLAIM, CROSS-CLAIM OR COUNTERCLAIM IN ANY WAY RELATING TO THIS AGREEMENT, EACH
          PARTY WAIVES THE RIGHT TO TRIAL BY JURY.

       

      (e)          Any notice, consent or request to
          be given in connection with any of the terms or provisions of this Agreement shall be in writing and shall be sent by express mail or similar private courier service, by certified mail (return receipt requested), by hand delivery or by electronic
          mail or facsimile transmission:

       

      
        7

        
          


      

      if to the Trustee, to:

       

      Continental Stock Transfer & Trust Company

      1 State Street, 30th Floor

      New York, New York 10004

      Attn:       Francis E. Wolf, Jr. & Celeste Gonzalez

      Email:    fwolf@continentalstock.com

      cgonzalez@continentalstock.com

       

      if to the Company, to:

       

      ARYA Sciences Acquisition Corp III

      51 Astor Place, 10th Floor

      New York, NY 10004

      Attn:       Samuel M. Cohn

      Email:     Cohn@perceptivelife.com

       

      in each case, with copies to:

       

      Kirkland & Ellis LLP

      601 Lexington Avenue

      New York, New York 10022

      Attn:      Christian O. Nagler

      Ross M. Leff

      Email:    cnagler@kirkland.com

      ross.leff@kirkland.com

       

      and

       

      Jefferies LLC

      520 Madison Avenue

      New York, New York 10022

      Attn:       General Counsel

      Facsimile: (646) 619-4437

       

      and

       

      Goldman Sachs & Co. LLC

      200 West Street

      New York, NY 10282

      Attn:       Registration Department

       

      and

       

      Skadden, Arps, Slate, Meagher & Flom LLP

      525 University Avenue, Suite 1400

      Palo Alto, California 94301

      Attn.:     Gregg A. Noel

      Michael J. Mies

      Email:    gregg.noel@skadden.com

      michael.mies@skadden.com

       

      
        8

        
          


      

      (f)           Each of the Company and the
          Trustee hereby represents that it has the full right and power and has been duly authorized to enter into this Agreement and to perform its respective obligations as contemplated hereunder. The Trustee acknowledges and agrees that it shall not
          make any claims or proceed against the Trust Account, including by way of set-off, and shall not be entitled to any funds in the Trust Account under any circumstance.

       

      (g)        This Agreement is the joint product
          of the Trustee and the Company and each provision hereof has been subject to the mutual consultation, negotiation and agreement of such parties and shall not be construed for or against any party hereto.

       

      (h)        This Agreement may be executed in
          any number of counterparts, each of which shall be deemed to be an original, but all such counterparts shall together constitute one and the same instrument. Delivery of a signed counterpart of this Agreement by facsimile or electronic
          transmission shall constitute valid and sufficient delivery thereof.

       

      (i)         Each of the Company and the Trustee
          hereby acknowledges and agrees that the Representatives on behalf of the Underwriters are third-party beneficiaries of this Agreement.

       

      (j)           Except as specified herein, no
          party to this Agreement may assign its rights or delegate its obligations hereunder to any other person or entity.

       

      [Signature Page Follows]

       

      
        9

        
          


      

      IN WITNESS WHEREOF, the parties have duly executed this Investment Management Trust Agreement as of the date first written above.

       

      	 	
              CONTINENTAL STOCK TRANSFER & TRUST COMPANY,

            
	 	
              as Trustee

            
	 	 
	 	
              By: 

            	/s/ Francis Wolf 

            
	 	
              Name: Francis Wolf

            
	 	
              Title:   Vice President

            
	 	 
	 	
              ARYA SCIENCES ACQUISITION CORP III

            
	 	 
	 	
              By: 

            	/s/ Samuel M. Cohn 

            
	 	
              Name: Samuel M. Cohn

            
	 	
              Title:   Secretary

            


      

      

      

      

      
        10

        
          


      

      SCHEDULE A

       

      	
              
                Fee Item

              

            	 	
              
                Time and method of payment

              

            	 	
              
                Amount

              

            	 
	
              Initial acceptance fee

            	 	
              Initial closing of the Offering by wire transfer

            	 	
              $

            	
              3,500.00

            	 
	
              Annual fee

            	 	
              First year, initial closing of the Offering by wire transfer; thereafter on the anniversary of the effective date of the Offering by wire transfer or check

            	 	
              $

            	
              10,000.00

            	 
	
              Transaction processing fee for disbursements to Company under Sections 1(i),(j), and (k)

            	 	
              Billed by Trustee to Company under Section 1

            	 	
              $

            	
              250.00

            	 
	
              Paying Agent services as required pursuant to Section 1(i) and 1(k)

            	 	
              Billed to Company upon delivery of service pursuant to Section 1(i) and 1(k)

            	 	
              Prevailing rates

            	 


      

      

      
        11

        
          


      

      EXHIBIT A

       

      [Letterhead of Company]

       

      [Insert date]

       

      Continental Stock Transfer & Trust Company

      1 State Street, 30th Floor

      New York, New York 10004

      Attn: Francis Wolf & Celeste Gonzalez

       

      Re:         Trust Account - Termination Letter

       

      Dear Mr. Wolf and Ms. Gonzalez:

       

      Pursuant to Section 1(i) of the Investment Management Trust Agreement
        between ARYA Sciences Acquisition Corp III (the “Company”) and Continental Stock Transfer & Trust Company (“Trustee”), dated as of August 11, 2020 (the “Trust
          Agreement”), this is to advise you that the Company has entered into an agreement with (the “Target Business”) to consummate a
        business combination with Target Business (the “Business Combination”) on or about [insert date]. The Company shall notify you at least
        seventy-two (72) hours in advance of the actual date (or such shorter time period as you may agree) of the consummation of the Business Combination (the “Consummation Date”). Capitalized terms used but not defined herein shall have the meanings set forth in the Trust Agreement.

       

      In accordance with the terms of the Trust Agreement, we hereby authorize you to commence to liquidate all of the assets of the Trust Account, and to
        transfer the proceeds into the trust operating account at J.P. Morgan Chase Bank, N.A. to the effect that, on the Consummation Date, all of the funds held in the Trust Account will be immediately available for transfer to the account or accounts
        that the Representatives (with respect to the Deferred Discount) and the Company shall direct on the Consummation Date. It is acknowledged and agreed that while the funds are on deposit in said trust operating account at J.P. Morgan Chase Bank,
        N.A. awaiting distribution, neither the Company nor the Representatives will earn any interest or dividends.

       

      On the Consummation Date (i) counsel for the Company shall deliver to you written notification that the Business Combination has been consummated, or
        will be consummated substantially concurrently with your transfer of funds to the accounts as directed by the Company (the “Notification”),
        and (ii) the Company shall deliver to you (a) a certificate of the Chief Executive Officer, Chief Financial Officer or other authorized officer of the Company, which verifies that the Business Combination has been approved by a vote of the
        Company’s shareholders, if a vote is held and (b) joint written instruction signed by the Company and the Representatives with respect to the transfer of the funds held in the Trust Account, including payment of the Deferred Discount from the Trust
        Account (the “Instruction Letter”). You are hereby directed and authorized to transfer the funds held in the Trust Account immediately upon
        your receipt of the Notification and the Instruction Letter, in accordance with the terms of the Instruction Letter. In the event that certain deposits held in the Trust Account may not be liquidated by the Consummation Date without penalty, you
        will notify the Company in writing of the same and the Company shall direct you as to whether such funds should remain in the Trust Account and be distributed after the Consummation Date to the Company. Upon the distribution of all the funds, net
        of any payments necessary for reasonable unreimbursed expenses related to liquidating the Trust Account, your obligations under the Trust Agreement shall be terminated.

       

      
        12

        
          


      

      In the event that the Business Combination is not consummated on the Consummation Date described in the notice thereof and we have not notified you on
        or before the original Consummation Date of a new Consummation Date, then upon receipt by the Trustee of written instructions from the Company, the funds held in the Trust Account shall be reinvested as provided in Section 1(c) of the Trust Agreement on the business day immediately following the Consummation Date as set forth in such notice as soon thereafter as possible.

       

      	 	
              Very truly yours,

            
	 	 
	 	
              ARYA Sciences Acquisition Corp III

            
	 	 
	 	
              By:

            	 
	 	
              Name:

            
	 	
              Title:

            


      

      

      	
              cc:

            	
              Jefferies LLC

            
	 	
              Goldman Sachs & Co. LLC

            


      

      

      
        13

        
          


      

      EXHIBIT B

       

      [Letterhead of Company]

       

      [Insert date]

       

      Continental Stock Transfer & Trust Company

      1 State Street, 30th Floor

      New York, New York 10004

      Attn: Francis Wolf & Celeste Gonzalez

       

      Re:         Trust Account - Termination Letter

       

      Dear Mr. Wolf and Ms. Gonzalez:

       

      Pursuant to Section 1(i) of the Investment Management Trust Agreement
        between ARYA Sciences Acquisition Corp III (the “Company”) and Continental Stock Transfer & Trust Company (the “Trustee”), dated as of August 11, 2020 (the “Trust
          Agreement”), this is to advise you that the Company has been unable to effect a business combination with a Target Business (the “Business
          Combination”) within the time frame specified in the Company’s Amended and Restated Memorandum and Articles of Association, as described in the Company’s Prospectus relating to the Offering. Capitalized terms used but not defined herein
        shall have the meanings set forth in the Trust Agreement.

       

      In accordance with the terms of the Trust Agreement, we hereby authorize you to liquidate all of the assets in the Trust Account and to transfer the
        total proceeds into the trust operating account at J.P. Morgan Chase Bank, N.A. to await distribution to the Public Shareholders. The Company has selected                
        as the effective date for the purpose of determining when the Public Shareholders will be entitled to receive their share of the liquidation proceeds. It is acknowledged that no interest will be earned by the Company on the liquidation proceeds
        while on deposit in the trust operating account. You agree to be the Paying Agent of record and, in your separate capacity as Paying Agent, agree to distribute said funds directly to the Company’s Public Shareholders in accordance with the terms of
        the Trust Agreement and the Amended and Restated Memorandum and Articles of Association of the Company. Upon the distribution of all the funds, net of any payments necessary for reasonable unreimbursed expenses related to liquidating the Trust
        Account, your obligations under the Trust Agreement shall be terminated, except to the extent otherwise provided in Section 1(j) of the Trust Agreement.

       

      	 	
              Very truly yours,

            
	 	 
	 	
              ARYA Sciences Acquisition Corp III

            
	 	 


      	 	
              By:

            	 


      	 	
              Name:

            
	 	
              Title:

            


      

      

      	
              cc:

            	
              Jefferies LLC

            
	 	
              Goldman Sachs & Co. LLC

            


       

      
        14

        
          


      

      EXHIBIT C

       

      [Letterhead of Company]

       

      [Insert date]

       

      Continental Stock Transfer & Trust Company

      1 State Street, 30th Floor

      New York, New York 10004

      Attn: Francis Wolf& Celeste Gonzalez

       

      Re:         Trust Account - Tax Payment Withdrawal Instruction

       

      Dear Mr. Wolf and Ms. Gonzalez:

       

      Pursuant to Section 1(j) of the Investment Management Trust Agreement
        between ARYA Sciences Acquisition Corp III (the “Company”) and Continental Stock Transfer & Trust Company (the “Trustee”), dated as of August 11, 2020 (the “Trust
          Agreement”), the Company hereby requests that you deliver to the Company $                of the interest income earned on the Property as of the date hereof.
        Capitalized terms used but not defined herein shall have the meanings set forth in the Trust Agreement.

       

      The Company needs such funds to pay for the tax obligations as set forth on the attached tax return or tax statement. In accordance with the terms of
        the Trust Agreement, you are hereby directed and authorized to transfer (via wire transfer) such funds promptly upon your receipt of this letter to the Company’s operating account at:

       

      [WIRE INSTRUCTION INFORMATION]

       

      	 	
              Very truly yours,

            
	 	 
	 	
              ARYA Sciences Acquisition Corp III

            
	 	 


      	 	
              By:

            	 


      	 	
              Name:

            
	 	
              Title:

            


      

      

      	
              cc:

            	
              Jefferies LLC

            
	 	
              Goldman Sachs & Co. LLC

            


       

      
        15

        
          


      

      EXHIBIT D

       

      [Letterhead of Company]

       

      [Insert date]

       

      Continental Stock Transfer & Trust Company

      1 State Street, 30th Floor

      New York, New York 10004

      Attn: Francis Wolf & Celeste Gonzalez

       

      Re:         Trust Account - Shareholder Redemption Withdrawal
            Instruction

       

      Dear Mr. Wolf and Ms. Gonzalez:

       

      Pursuant to Section 1(k) of the Investment Management Trust Agreement
        between ARYA Sciences Acquisition Corp III (the “Company”) and Continental Stock Transfer & Trust Company (the “Trustee”), dated as of August 11, 2020 (the “Trust
          Agreement”), the Company hereby requests that you deliver to the redeeming Public Shareholders on behalf of the Company $                of the principal and
        interest income earned on the Property as of the date hereof. Capitalized terms used but not defined herein shall have the meanings set forth in the Trust Agreement.

       

      Pursuant to Section 1(k) of the Trust Agreement, this is to advise you
        that the Company has sought an Amendment. Accordingly, in accordance with the terms of the Trust Agreement, we hereby authorize you to liquidate a sufficient portion of the Trust Account and to transfer $[●] of the proceeds of the Trust Account to
        the trust operating account at J.P. Morgan Chase Bank, N.A. for distribution to the shareholders that have requested redemption of their shares in connection with such Amendment.

       

      	 	
              Very truly yours,

            
	 	 
	 	
              ARYA Sciences Acquisition Corp III

            
	 	 
	 	
              By:

            	 
	 	
              Name:

            
	 	
              Title:

            


      

      

      	
              cc:

            	
              Jefferies LLC

            
	 	
              Goldman Sachs & Co. LLC

            


      

      

      

      

      
        16