#### § 558.586 Sulfaquinoxaline.

(a) *Specifications.* Type A medicated articles containing 40 percent sulfaquinoxaline.

(b) *Sponsor.* See No. 016592 in [§ 510.600(c) of this chapter](/on/2024-09-23/title-21/section-510.600#p-510.600(c)).

(c) *Related tolerances.* See [§ 556.685 of this chapter](/on/2024-09-23/title-21/section-556.685).

(d) *Special considerations.*

(1) Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. See [§ 558.6](/on/2024-09-23/title-21/section-558.6) for additional requirements.

(2) The expiration date of VFDs for sulfaquinoxaline medicated feeds must not exceed 6 months from the date of issuance. VFDs for sulfaquinoxaline shall not be refilled.

(e) *Conditions of use* —

(1) *Chickens* —

| Sulfaquinoxaline in grams/ton | Combination in grams/ton | Indications for use | Limitations | Sponsor |
| --- | --- | --- | --- | --- |
| (i) 0.015 percent | | As an aid in preventing outbreaks of coccidiosis caused by *Eimeria tenella, E. necatrix,* *E. acervulina, E. maxima,* and *E. brunetti* under average conditions of exposure | Feed continuously from the time birds are placed on litter and continue past the age when coccidiosis is ordinarily a hazard. If death losses exceed 0.5 percent in a 2-day period, obtain a laboratory diagnosis. If coccidiosis is the cause, use the sulfaquinoxaline levels recommended for control of outbreaks, returning to the original dosage schedule after the outbreak has subsided. Losses may result from intercurrent disease, other conditions affecting drug intake, or variant strains of coccidia species which can contribute to the virulence of coccidiosis under field conditions. Do not treat chickens within 10 days of slaughter. Do not medicate chickens producing eggs for human consumption | 016592 |
| (ii) 0.0175 percent | | As an aid in preventing outbreaks of coccidiosis caused by *Eimeria tenella, E. necatrix,* *E. acervulina, E. maxima,* and *E. brunetti* where excessive exposure to coccidia is increased due to overcrowding or other management factors | Feed continuously from the time birds are placed on litter and continue past the age when coccidiosis is ordinarily a hazard. If death losses exceed 0.5 percent in a 2-day period, obtain a laboratory diagnosis. If coccidiosis is the cause, use the sulfaquinoxaline levels recommended for control of outbreaks, returning to the original dosage schedule after the outbreak has subsided. Losses may result from intercurrent disease, other conditions affecting drug intake, or variant strains of coccidia species which can contribute to the virulence of coccidiosis under field conditions. Do not treat chickens within 10 days of slaughter. Do not medicate chickens producing eggs for human consumption | 016592 |
| (iii) 0.1 to 0.05 percent | | As an aid in controlling outbreaks of coccidiosis caused by *Eimeria tenella, E. necatrix,* *E. acervulina, E. maxima,* and *E. brunetti* | Feed at 0.1 percent level for first 48 to 72 hours. Skip 3 days; 0.05 percent for 2 days, skip 3 days; 0.05 percent for 2 days. If bloody droppings recur, give 0.05 percent for another 2 days. Do not treat chickens within 10 days of slaughter. Do not medicate chickens producing eggs for human consumption | 016592 |
| (iv) 0.05 or 0.1 percent | | As an aid in the control of acute fowl cholera caused by *Pasteurella multocida* susceptible to sulfaquinoxaline and fowl typhoid caused by *Salmonella gallinarum* susceptible to sulfaquinoxaline | Feed 0.1 percent for 48 to 72 hours. Mortality should be brought under control. After medication, move birds to clean ground or to a clean house. If disease recurs, use 0.05 percent in feed again for 2 days. Do not treat chickens or turkeys within 10 days of slaughter for food. Do not medicate chickens or turkeys producing eggs for human consumption | 016592 |

(2) *Turkeys* —

| Sulfaquinoxaline in grams/ton | Combination in grams/ton | Indications for use | Limitations | Sponsor |
| --- | --- | --- | --- | --- |
| (i) 0.0175 percent | | As an aid in preventing outbreaks of coccidiosis caused by *Eimeria meleagrimitis* and *E. adenoeides* | Feed continuously during time birds are closely confined. May be continued for a week to 10 days after flock is transferred to range to reduce danger of an outbreak following moving of the flock. Do not treat turkeys within 10 days of slaughter. Do not medicate turkeys producing eggs for human consumption | 016592 |
| (ii) 0.05 percent | | As an aid in controlling outbreaks of coccidiosis caused by *Eimeria meleagrimitis* and *E. adenoeides* | Feed for 2 days. Follow with 3 days on regular feed and 2 more days on 0.05 percent sulfaquinoxaline feed. Again follow with 3 days on regular feed and 2 more days on 0.05 percent sulfaquinoxaline feed. Continue this schedule if necessary until all signs of the outbreaks have subsided. Do not treat turkeys within 10 days of slaughter. Do not medicate turkeys producing eggs for human consumption | 016592 |
| (iii) 0.05 or 0.1 percent | | As an aid in the control of acute fowl cholera caused by *Pasteurella multocida* susceptible to sulfaquinoxaline and fowl typhoid caused by *Salmonella gallinarum* susceptible to sulfaquinoxaline | Feed 0.1 percent for 48 to 72 hours. Mortality should be brought under control. After medication, move birds to clean ground or to a clean house. If disease recurs, use 0.05 percent in feed again for 2 days. Do not treat chickens or turkeys within 10 days of slaughter for food. Do not medicate chickens or turkeys producing eggs for human consumption | 016592 |

(3) *Rabbits* —

| Sulfaquinoxaline in grams/ton | Combination in grams/ton | Indications for use | Limitations | Sponsor |
| --- | --- | --- | --- | --- |
| (i) 0.025 percent | | As an aid in preventing coccidiosis caused by *Eimeria stiedae* | Treatment to be started after weaning. Feed continuously for 30 days or feed medicated feed for 2 days out of every week until marketing. Do not treat within 10 days of slaughter | 016592 |
| (ii) 0.1 percent | | As an aid in controlling outbreaks of coccidiosis caused by *Eimeria stiedae* | Feed for 2 weeks. Do not treat within 10 days of slaughter | 016592 |

[[81 FR 95013](https://www.federalregister.gov/citation/81-FR-95013), Dec. 27, 2016]