# United States Chemical Safety December 2011

Environmental Protection and Pollution Prevention

Agency (7510P)



# Methylene Bis(Thiocyanate)

Summary Document:

Registration Review: Initial Docket

December 2011

# Docket Number: EPA-HQ-OPP-2011-0613

www.regulations.gov



# Methylene Bis(Thiocyanate)

Summary Document

Registration Review: Initial Docket

December 2011

Case # 2415

Date:

20[50

# Docket Number: EPA-HQ-OPP-2011-0613

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3 of 50 

# TABLE OF CONTENTS

Methylene Bis(Thiocyanate) Registration Review Team .......................................................... 4

I. Preliminary Work Plan -- Methylene Bis(Thiocyanate) ........................................................ 5

II. Fact Sheet

.............................................................................................................................. .. 13

III. Summary of Anticipated Data Requirements – Methylene Bis(Thiocyanate) ............... 19

IV. Appendix A: Use Patterns – Methylene Bis(Thiocyanate) .............................................. 21

________________________________________

Please Note

This Preliminary Work Plan and Fact Sheet su mmarize the Environmental Protection Agency's

current position based on the following documents:

1. Product Chemistry, Environmental Fate, and Ecological Effects Scoping Document in

Support of Registration Review of Methyl ene bis(thiocyanate). November 22, 2011

2. Methylene Bis Thiocyanate (MBT): Human Health Risk Assessment Scoping Document

in Support of Registration Review. October 17, 2011

Additional supporting documents fo r the Methylene Bis(Thiocyanate) Case may be found in the

registration review docket EPA-HQ-OPP-2011-0613 located on the internet at

www.regulations.gov

.

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4 of 50 Methylene Bis(Thiocyanate) Registration Review Team

Human Health & Environmental Effects

Nathan Mottl

Steven Malish

Jonathan Chen

Srinivas Gowda

Najm Shamim

William Erickson

Risk Management

Rebecca von dem Hagen

Lance Wormell

Office of General Counsel

Philip Ross

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5 of 50 I. Preliminary Work Plan -- Methylene Bis(Thiocyanate)

Introduction:

The Food Quality Protection Act (FQPA) of 1996 mandated a regi stration review program. All

pesticides distributed or sold in the United St ates generally must be registered by the U.S.

Environmental Protection Agency (USEPA, EPA, or the Agency ) based on scientific data

showing that they will not cause unreasonable ri sks to human health or the environment when

used as directed on product labeling. The regist ration review program is intended to make sure

that, as the ability to assess risk evolves and as policies and practices change, all registered

pesticides continue to meet th e statutory standard of no unreas onable adverse effects to human

health or the environment. Changes in science, public policy, and pesticide use practices will

occur over time. Through the registration review program, the Agency periodically reevaluates

pesticides to make sure that as change occurs , products in the marketpl ace can be used safely.

Information on this program is provided at http://www.epa.gov/oppsrrd1/registration_review/

.

The Agency is implementing the registration revi ew program pursuant to Section 3(g) of the

Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and will review each registered

pesticide every 15 years to determine whether it continues to meet th e FIFRA standard for

registration. The Agency will consid er benefits information and data as required by FIFRA. The

public phase of registration review begins when the initial docket is opened for each case. The

docket is the Agency’s opportunity to state whatit knows about the pesticide and what additional

risk analyses and data or information it belie ves are needed to make a registration review

decision. After reviewing and responding to co mments and data received in the docket during

this initial comment period, the Agency will de velop and commit to a final work plan and

schedule for the Methylene Bis(Thiocyanate) Case.

The Methylene Bis(Thiocyanate) Case (Case Nu mber 2415) includes one active ingredient, PC

Code 068102. The first product containing methyl ene bis(thiocyanate) (MBT) as an active

ingredient was registered in the United Stat es in 1949. Currently, there are 40 MBT products

registered with EPA. Products containing MBT are registered for use as material preservatives

for incorporation into products such as adhesive s, coatings, fuels, metalworking cutting fluids,

textiles, plastic products, resin emulsions, paints , paper products and various other products.

Products containing MBT are also registered as microbiocides for use in pulp/paper mills,

cooling water systems (recirculating), oil fiel d operations, air washer systems, brewery

pateurizers, hydrotesting, leat her processing and industrial wa ter supply systems. MBTcontaining products are also register ed for use as wood preservatives.

No tolerances or exemptions from tolerances have been established for MBT. MBT is cleared as

an indirect additive in food cont act substances for slimicides in paper and paperboards by FDA

(29 CFR 176.300). Also, FDA has cleared the use of MBT in a dhesives under a threshold of

regulation; MBT can only be used in packaging ma terials for dry foods at a level not to exceed

0.01% active ingredie nt (21 CFR 170.39).

The Agency completed a Reregistration E ligibility Decision (RED) for methylene

(bis)thiocyanate in 1997. At the time of the RED, the Agency was unable to make a

reregistration decision on MBT’s use as a wood preservative, in leather processing liquid and

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6 of 50 products and in paint due to th e lack of data. The Agency has since received the 90-day

inhalation study (MRID 45366301) and intends to incorporate it in th e anticipated risk

assessments for the registration review of MBT.

Documents associated with the registration review of methylene bis(thiocyanate) can be viewed

at www.regulations.gov in docke t EPA-HQ-OPP-2011-0613. Below is a summary of the issues

relevant to this registration review case.

Anticipated Risk Assessment and Data Needs:

The Agency anticipates the need to conduct a comprehensive ecological risk assessment,

including an endangered species risk assessment, for all uses of methylene (bis)thiocyanate. The

Agency also anticipates the need to conduct a human health risk assessment. The Agency

anticipates needing additional data for use in conducting the registration review for MBT.

Ecological Risk:

 A quantitative ecological risk assessment was not performed for MBT at the time of the

RED because the Agency did not anticipate any exposure of concern to fish, wildlife,

and/or endangered species based on the registered use patterns and that discharges to the

environment complied with all Federal dis posal laws and NPDES. For registration

review, the Agency anticipate s the need to conduct a co mprehensive ecological risk

assessment for MBT.

 The Agency has not conducted a risk asse ssment that supports a complete endangered

species determination for MBT. The eco logical risk assessment planned during

registration review will allow the Agency to determine whether MBT’s use has 'no effect'

or 'may affect' federally listed threatened or endangered species (lis ted species) or their

designated critical habitats. When an assessm ent concludes that a pesticide’s use 'may

affect' a listed species or its designated critic al habitat, the Agency will consult with the

U.S. Fish and Wildlife Service and/or National Marine Fisheries Services (the Services),

as appropriate.

 The Agency anticipates the need to require the following additional ecological data for

use in the registration review of methylene (bis)thiocyanate.

850.1400 -- Fish early-life stage to xicity test (freshwater)

850.4400 -- Aquatic plant toxicology test using Lemna spp., Tier I

850.5400 -- Algal Toxicity Tier I and Tier II

850.3020 -- Honey bee acute contact toxicity

850.3030 -- Honey bee toxicity of residues on foliage

850.1735 -- Whole sediment acute toxici ty invertebrates (freshwater) 1



# 850.1740 -- Whole sediment acute toxi city invertebrates (marine) 1



# Special Study -- Chronic sediment toxi city test (freshwater invertebrate) 1

1 

# If the environmental fate data anticipated as being requi red for this registration review demonstrate that the halflife of the MBT in the sediment is greater than 10 days and if any one of the following conditions are met (1) Kd

<50, (2) Koc <1000, or (3) Kow <3, then the registrant may request that the Agency waive the sediment studies.

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7 of 50  The Agency anticipates the need to require the following additional environmental fate

data for use in the registration revi ew of methylene (bis)thiocyanate.

835.2240 -- Photodegradation in water (at pH 5)

835.1240 -- Adsorption/desorption

835.4300 -- Aerobic aquatic metabolism

835.4400 -- Anaerobic aquatic metabolism

850.6800 -- Modified activated sludge , respiration inhibition test 2



# 835.3110 -- Ready Biodegradability 2



# 835.3220 -- Porous Pot Test 2



# 835.3280 -- Simulation Tests to Assess the Biodeg radability of Chemicals Discharged

to Wastewater 2



# 835.3240 -- Simulation Test – Aerobic Sewage Treatment: A. Activated Sludge Units 2



# Special Study -- Leachability of wood pres ervatives used in contact with water

 For more information, please refer to Product Chemistry, Environmental Fate, and

Ecological Effects Scoping Document in Suppor t of Registration Re view of Methylene

bis(thiocyanate) , located in the docket.

Human Health Risk:

 The most recent human health risk assessmen ts for methylene (bis)thiocyanate were

completed in 1997, in support of the RED.

 The Agency anticipates the need to require the following additional human health data

for use in conducting occupational, residential, dietary and aggregate risk assessments for

the registration review of methylene (bis)thiocyanate.

875.1200 -- Dermal indoor exposure

875.1400 -- Inhalation indoor exposure

875.1600 -- Application exposure data reporting and calculations

875.2300 -- Indoor surface residue dissipation

875.2500 -- Inhalation exposure

875.2800 -- Description of human activity

875.2900 -- Data reporti ng and calculations

875.1700 -- Product use information (handler)

875.2700 -- Product use information (postapplication)

2 

# The results of the Activated Sludge Respiration Inhibitio n Test (ASRI) that is expected to be required would

determine which of these three biodegradation tests would be anticipated to be required. If the ASRI test EC 50 

# is

less than or equal to 20 mg/L, then either the Biodegradation in Activated Sludge Study or Simulation Test –

Aerobic Sewage Treatment: A. Activated Sludge Units or the Porous Pot Test would be anticipated to be required.

If the ASRI test EC 50 

# is greater than 20 mg/L, then the applicant would choose to conduct either: (i) Ready

Biodegradability or (ii) Biodegradation in Activated Slu dge or Simulation Test – Aerobic Sewage Treatment: A.

Activated Sludge Units or the Porous Pot Test. If the antimicrobial passes the ready biodegradability study, then no

further testing would be expected to be required. If , however, the antimicrobial fails the ready biodegradability

study, then the Biodegradation in Activated Sludge or Simulation Test – Aerobic Sewage Treatment: A. Activated

Sludge Units, or the Porous Pot study would be expected to be required.

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8 of 50  The Agency anticipates the need to conduct an aggregate risk assessment based on the

potential for residential, diet ary and drinking water exposure.

 For more information, please refer to Methylene Bis Thiocyanate (MBT): Human Health

Risk Assessment Scoping Document in Support of Registration Review , located in the

docket.

Product Chemistry:

 The Agency does not anticipate the need to require additional product chemistry data for

this registration review case at this time.

 For more information, please refer to Product Chemistry, Environmental Fate, and

Ecological Effects Scoping Document in Suppor t of Registration Re view of Methylene

bis(thiocyanate) , located in the docket.

Endocrine Disruptor Screening Program

As required by FIFRA and FFDCA, EPA reviews num erous studies to asse ss potential adverse

outcomes from exposure to chemicals. Collectiv ely, these studies includ e acute, subchronic and

chronic toxicity, including asse ssments of carcinogenicity, ne urotoxicity, developmental,

reproductive, and general or systemic toxicity. These studies include endpoints which may be

susceptible to endocrine influe nce, including effects on endocri ne target organ histopathology,

organ weights, estrus cyclicity, sexual maturatio n, fertility, pregnancy rates, reproductive loss,

and sex ratios in offspring. For ecological hazard assessments, EPA evaluates acute tests and

chronic studies that assess gr owth, developmental and reprod uctive effects in different

taxonomic groups. As part of its 1997 Reregi stration Eligibility Decision for MBT, EPA

reviewed these data and select ed the most sensitive endpoints for relevant risk assessment

scenarios from the existing hazard database. However, as required by FFDCA section 408(p),

methylene (bis)thiocyanate is subject to the endo crine screening part of the Endocrine Disruptor

Screening Program (EDSP).

EPA has developed the EDSP to determine whet her certain substances (including pesticide

active and other ingredients) may have an effect in humans or wildlife similar to an effect

produced by a “naturally occurring estrogen, or ot her such endocrine effect s as the Administrator

may designate.” The EDSP employs a two-tiered approach to making th e statutorily required

determinations. Tier 1 consists of a battery of 11 screening assays to identify the potential of a

chemical substance to interact with the estrog en, androgen, or thyroid (E, A, or T) hormonal

systems. Chemicals that go th rough Tier 1 screening and are found to have the potential to

interact with E, A, or T hormonal systems will proceed to the next stag e of the EDSP where EPA

will determine which, if any, of th e Tier 2 tests are necessary base d on the available data. Tier 2

testing is designed to identify a ny adverse endocrine-related eff ects caused by the substance, and

establish a dose-response relationship between the dose and the E, A, or T effect.

Under FFDCA section 408(p), the Agency must scre en all pesticide chemicals. Between October

2009 and February 2010, EPA issued test orders/dat a call-ins for the firs t group of 67 chemicals,

which contains 58 pesticide active ingredients and 9 inert ingredients. Methylene

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9 of 50 (bis)thiocyanate is not among the group of 58 pestic ide active ingredients on th e initial list to be

screened under the EDSP. Accordingly, as part of registration review, EPA will issue future

EDSP orders/data call-ins, requiring the submi ssion of EDSP screening assays for methylene

(bis)thiocyanate. For further information on the st atus of the EDSP, the policies and procedures,

the list of 67 chemicals, future lists, the test guidelines and the Tier 1 screening battery, please

visit our website: http://www.epa.gov/endo/.

Timeline

EPA has created the following estimated timeline for the completion of the Methylene

bis(thiocyanate) registration review:

Anticipated Schedule

Activities Estimated Month/Year

Phase 1: Opening the docket

Open Public Comment Period for Docket December 2011

Close Public Comment Period for Docket February 2012

Phase 2: Case Development

Develop Final Work Plan (FWP) June 2012

Issue DCI June 2013

Data Submission June 2015

Open Public Comment Period for Prelim inary Risk Assessments December 2016

Close Public Comment Period for Prelim inary Risk Assessments January 2017

Phase 3: Registration Review Decision

Open Public Comment Period for Pro posed Reg. Review Decision June 2017

Close Public Comment Period for Pro posed Reg. Review Decision August 2017

Final Decision and Begin Post-Decision Follow-up 2017

Total (years) 6

Guidance for Commenters:

The public is invited to comment on EPA’s Preliminary Work Plan and rationale. The Agency

will carefully consider all comments as well as any additional information or data provided in a

timely manner prior to issuing a final work plan for the Methylene bis(thiocyanate) registration

review case.

Trade Irritants:

Through the registration review process, the Ag ency intends to solicit information on trade

irritants and, to the extent feas ible, take steps toward facilitating irritant resolution. Growers and

other stakeholders are asked to comment on any tr ade irritant issues resulting from lack of

Maximum Residue Limits (MRLs) or disparitie s between U.S. tolerances and MRLs in key

export markets, providing as much specificity as possible regarding the na ture of the concern.

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10 of 50 Water Quality:

Methylene (bis)thiocyanate is not identified as a cause of impairme nt for any water bodies listed

as impaired under section 303(d) of the Clean Water Act, based on information provided at

http://iaspub.epa.gov/tmdl_waters10/attains_ nation_cy.cause_detail_303d?p_cause_group_id=88

5. In addition, no Total Maximum Daily Loads (TMDL) have been developed for methylene

(bis)thiocyanate, based on information provided at

http://iaspub.epa.gov/tmdl_waters10/attains_ nation.tmdl_pollutant_de tail?p_pollutant_group_id

=885&p_pollutant_group_name=PESTICIDES.

More information on impaired wate r bodies and TMDLs can be found at

http://www.epa.gov/owow/tmdl/ . The Agency invites submission of water quality data for this

pesticide. To the extent possible, data should co nform to the quality standards in Appendix A of

the OPP Standard Operating Procedure: Inclus ion of Impaired Water Body and Other Water

Quality Data in OPP’s Registration Revi ew Risk Assessment and Management Process (see:

http://www.epa.gov/oppsrrd1/regist ration_review/water_quality_sop.htm ), in order to ensure the

data can be used quantitatively or qual itatively in pesticide risk assessments.

Environmental Justice:

EPA seeks to achieve environmenta l justice, the fair tr eatment and meaningful involvement of all

people, regardless of race, color, national origi n, or income, in the deve lopment, implementation,

and enforcement of environmental laws, regulations, and policies. To help address potential

environmental justice issues, the Agency seeks information on any groups or segments of the

population who, as a result of thei r location, cultural practices, or other factors, may have

atypical, unusually high exposur e to methylene (bis)thiocyanate compared to the general

population. Please comment if you ar e aware of any sub-populations that may have atypical,

unusually high exposure compared to the general population.

Structure Activity Relationships:

EPA must rely upon information of appropriate qual ity and reliability for each decision made by

the Agency. In the Office of Pesticide Program s (OPP), the evaluation process for a pesticide

chemical traditionally begins with the applicant’ s submission of a set of studies conducted with

the specific pesticide chemical of interest. The us e of the results of such testing (measured data)

is a logical, scientifically rigorous proce ss that identifies the physical, chemical, and

environmental fate properties of the pesticide, as well as the dose and endpoints at which an

adverse effect can occur in various animal species.

Today, there is significant interest in alternat ive techniques, i.e., tech niques other than data

generation that could significantly inform the Agency’s decision-making process. Recently, OPP

has made increasing use of stru cture activity relationship (SAR ) as part of its regulatory

decision-making process. In the SAR process, a ch emical's molecular structure is compared to

that of other chemicals for which data are availabl e. These structural similarities are then used to

make predictive judgments about a chemical’s physical, chemical, and biological properties.

Thus, the chemical’s physical, chemical, and biol ogical properties are a f unction of (or directly

related to) the chemical’s molecular structure. Quantitative SAR is referred to as QSAR. To

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11 of 50 develop a QSAR, a selected set of measured da ta on a single physical, chemical, or biological

property is used to derive a model (an equatio n) to predict the valu e of that property.

Since SAR assessments and QSAR modeling are anothe r set of tools that are available to Agency

scientists, OPP has begun a proce ss shift that envisions shifting from the current study-by-study

approach to an approach in which the use of pr edicted data, generated us ing validated models, is

considered along with information from open litera ture and studies specifically generated under

Part 161 requirements. All relevant information w ould be considered as pa rt of a weight-of-theevidence evaluation.

At this time, EPA believes that for certain e ndpoints, especially physi cal/chemical and fate

properties, that SAR and QSAR might be effect ively utilized to fulfill these data requirements

for many antimicrobial pesticide chemicals. When considering biological prope rties, at this time,

EPA believes that SAR and QSAR can be most effectively utilized in the evaluation of

chemicals that exhibit lower toxicity for human health and/or ecotoxicity parameters. This is

appropriate because the risk assessment for lower toxicity chemicals can be stream-lined, i.e., a

screening-level assessment procedure rather than multiple tiers of assessments with progressively

more data requirements.

If stakeholders believe that submission of predic ted data can fulfill one of the data needs for the

Methylene Bis(Thiocyanate) case, then the Agen cy invites submission of this information. The

submitter would be expected to supply a rationale describing the utility of the information and

provide documentation on the scient ific validity of the informa tion. The determination that the

predicted data fulfills the data requirement woul d be at the sole discretion of the Agency. Presubmission consultation with the Agency is encouraged.

Additional Information:

Stakeholders are also specifically asked to provid e available information a nd data that will assist

the Agency in refining its risk assessments, including any species-spec ific ecological effects

determinations. The Agency is interested in receiving the following information:

1. Confirmation on the following label information:

a. Sites of application

b. Formulations

c. Application methods and equipment

d. Maximum application rates

e. Frequency of application, applicatio n intervals and maximum number of

applications

f. Geographic limitations on use

2. Use or potential use distribution

3. Use history

4. Usage/use information for non-agricultura l uses (e.g., materials preservation)

5. Typical application interval

6. State or local use restrictions

7. Ecological incidents (non-target plant dama ge and avian, fish, reptilian, amphibian

and mammalian mortalities) not already reported to the Agency

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12 of 50 8. Monitoring data

Next Steps:

After the 60-day comment period closes in February 2012, the Agency will review and respond

to any comments received in a timely manner, and then issue a Final Work Plan for the

Methylene Bis(Thiocyanate) Case.

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13 of 50 II. Fact Sheet

Background Information:

 Active Ingredient: methylene bis(thiocyanate) (MBT)

 Case number: 2415

 PC Code: 068102

 CAS number: 6317-18-6

 Technical registrants: Buckman Laboratories Inc., ICL-IP America, Inc., Kemira

Chemicals, Inc., Rhodia UK Limited, Lamirsa Laboratories Miret S.A., Verichem, Inc.

 First approved for use in a registered product: 1949

 No tolerances or exemptions from tole rances have been established for MBT.

 Antimicrobials Division Chemical Review Manager (CRM): Rebecca von dem Hagen,

vondem-hagen.rebecca@epa.gov

 Antimicrobials Division Product Ma nager (PM): Marshall Swindell,

swindell.marshall@epa.gov

 Chemical Structure:

Use & Usage Information:

 MBT-containing products are registered fo r use as material preservatives for

incorporation into products su ch as adhesives, coatings, fuels, metalworking cutting

fluids, textiles, plastic products, resin emulsions, paints, paper products and various other

products. Products containing MBT ares also registered as microbiocides for use in

pulp/paper mills, cooling water systems (recirculating), oil field operations, air washer

systems, brewery pateurizers, hydrotesting, le ather processing and industrial water supply

systems. MBT-containing products are also re gistered for use as wood preservatives to

control wood sapstain and mold on freshl y cut hardwood and softwood lumber, logs,

poles, posts and timbers.

Recent/Pending Regulatory Actions:

 There are no recent or pending regulatory actions for MBT.

Ecological Risk Assessment Status:

Please refer to Product Chemistry, Environmental Fa te, and Ecological Effects Scoping

Document in Support of Registration R eview of Methylene bis(thiocyanate) , located in the

docket, for a detailed discussion of the ecological risk assessments.

 A qualitative hazard characterization for a quatic organisms exposed to methylene

bis(thiocyanate) was complete d in support of the 1997 RED.

 MBT is highly toxic to birds on an acute-oral basis but practically nontoxic on a dietary

basis. MBT is of high to very high acute toxi city to freshwater and estuarine/marine fish

and of very high toxicity to aquatic invertebrates.

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14 of 50  MBT is hydrolytically stable at pH 5, but degrades easily at pHs 7, and 9. The Agency

does not expect that MBT will bioaccumulate as its Log K

ow 

# is around 2.

 The common degradates of MBT which can be formed through hydrolysis and photolysis

are thiocyanate, formic acid, and carbon dioxide. Under environmental conditions

formation of cyanide from the thiocyanat e moiety is not known to occur.

Human Health Risk Assessment Status:

The following are key findings of the recent human health risk assessments for Methylene

bis(thiocyanate). Please refer to Methylene Bis Thiocyanate (MBT): Human Health Risk

Assessment Scoping Document in Support of Registration Review , located in the docket, for a

detailed discussion of the hu man health risk assessment.

Hazard Characterization:

 MBT is of severe acute toxicity via the inha lation route and moderate acute toxicity via

the dermal and oral routes. It is a moderate to severe dermal irritant and a positive skin

sensitizer.

Dietary (Food and Water):

 A dietary exposure and risk assessmen t has not been performed for MBT.

Residential:

 The most recent residential assessment was performed for the 1997 RED on dermal

exposure. Inhalation exposure was not asse ssed for the RED due to lack of data.

Aggregate:

 An aggregate assessment has not been conducted on MBT.

Occupational:

 The most recent occupational assessment was performed for the 1997 RED on dermal

exposure. Inhalation exposure was not asse ssed for the RED due to lack of data.

 Through the RED the Agency required mitigation measures including limiting

mixing/loading systems to closed meteri ng systems for liquid product formulations

applied to cooling water systems that were greater than 4000 gall ons and specified the

following label statement: "Do not apply by open pouring of liquid to cooling water

systems; a metering pump delivery system is required for this use and application

method."

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15 of 50 Cumulative:

 EPA does not have, at this time, available data to determine whether methylene

(bis)thiocyanate has a common mechanism of to xicity with other substances or how to

include this pesticide in a cumulative ri sk assessment. For the purposes of this

registration review, EPA has assumed that me thylene (bis)thiocyanate does not have a

common mechanism of toxicity with other subs tances when used as an antimicrobial as

registered.

Incidents:

Ecological:

 No methylene (bis)thiocyanate ecological incidents have b een reported in the Agency’s

Ecological Incident Information System (EIIS).

Human Health:

 There are nine MBT-specific incidents that have been reported in the Office of Pesticide

Program Incident Data System (IDS). Most of the incidents we re as a result of

acute/short term inhalation expos ure. Workers reported irr itation and burning of the lung

tissue as well as airway and vocal cord dys function. Long-term resp iratory irritation has

been reported in workers working with MBT containing products. There have also been

skin irritation incidents reported.

Tolerances and International Harmonization:

 No tolerances or exemptions from tole rances have been established for MBT.

Data Call-In Status:

 The first MBT DCI was issued in March l987. A second DCI was issued as part of the

Phase 4 reregistration in June 1991. The Agency also issued DCIs in June 1993 for

additional environmental fate data on a quatic exposure and March 1997 for additional

inhalation toxicity data in support of the RED. A post-RED Product Specific DCI

(PDCI) was issued in September 1997. There are currently no outstanding DCI data

requirements for MBT.

Labels:

Registered products, including EP A registration numbers are provi ded in Table 1 below. For

future reference, during registra tion review a list of product regi stration numbers will be included

in the docket. Product registration labels may be obtained from the Pesticide Product Label

System (PPLS) website at: http ://oaspub.epa.gov/pestlabl/ppls.home

.

Table 1. Registered Products – Methylene (Bis)Thiocyanate

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16 of 50 Registration

No. Registration

Name Company

Name Formulation

Type % of Active

Ingredient

1022-583 NEXGEN IBC

Manufacturing

Co. Emulsifiable

Concentrate 14.7

1448-34 MTC-10 Buckman

Laboratories Inc. Ready-to-Use

Solution 10

1448-80 METHYLENE

BIS(THIOCYANATE) Buckman

Laboratories Inc. Technical

Chemical 99

1448-81 BUSAN 1009 Buckman

Laboratories Inc. Ready-to-Use

Solution 10

1448-102 BUSAN 1071 Buckman

Laboratories Inc. Soluble

Concentrate 2.5

1448-147 M-20-1 Buckman

Laboratories Inc. Ready-to-Use

Solution 10

1448-148 M-20-2 Buckman

Laboratories Inc. Soluble

Concentrate 10

1448-171 M-5-1 Buckman

Laboratories Inc. Ready-to-Use

Solution 2.5

1448-172 M-5-2 Buckman

Laboratories Inc. Soluble

Concentrate 2.5

1448-357 MTC-10-SR Buckman

Laboratories Inc. Ready-to-Use

Solution 10

1448-358 MTC-10-CT Buckman

Laboratories Inc. Ready-to-Use

Solution 10

1448-359 MTC-10WB-CT Buckman

Laboratories Inc. Ready-to-Use

Solution 10

1448-360 MTC-10WB-SR Buckman

Laboratories Inc. Ready-to-Use

Solution 10

1448-375 MECT-F Buckman

Laboratories Inc. Formulation

Intermediate 10

1448-376 BUSAN 1071WB Buckman

Laboratories Inc. Wettable

Powder 2.5

1448-377 BUSAN 1009 WB Buckman

Laboratories Inc. Ready-to-Use

Solution 10

1448-408 BUSAN 1350 Buckman

Laboratories Inc. Wettable

Powder 8

# Docket Number: EPA-HQ-OPP-2011-0613

www.regulations.gov

17 of 50 Registration

No. Registration

Name Company

Name Formulation

Type % of Active

Ingredient

1448-435 BUSAN 1265WB Buckman

Laboratories Inc. Soluble

Concentrate/

Solid 10

1448-438 BUSAN 1223 Buckman

Laboratories Inc. Emulsifiable

Concentrate 10

1448-439 BUSAN 1234 Buckman

Laboratories Inc. Soluble

Concentrate 10

1706-112 NALCON 7619 Nalco Company Ready-to-Use

Solution 10

1706-200 NALCON 10WB Nalco Company Ready-to-Use

Solution 10

3876-121 GE BETZ SLIMICIDE C31 GE Betz, Inc. Ready-to-Use

Solution 5

8622-42 METHYLENE BIS

(THIOCYANATE) ICL-IP America,

Inc. Technical

Chemical 99

9386-4 AMA-10 Kemira

Chemicals, Inc. Ready-to-Use

Solution 10

9386-12 THIONATE Kemira

Chemicals, Inc. Technical

Chemical 99

9386-26 AMA-10S Kemira

Chemicals, Inc. Ready-to-Use

Solution 10

9386-31 AMA-10W Kemira

Chemicals, Inc. Ready-to-Use

Solution 10

33677-1 TOLCIDE(R) MBT Rhodia UK

Limited Technical

Chemical 99

47091-12 SM-10P INDUSTRIAL

MICROBIOCIDE Aurora Specialty

Chemistries Ready-to-Use

Solution 10

56156-1 X-100 NATURAL SEAL

WOOD PRESERVATIVE American

Building

Restoration

Products Inc Ready-to-Use

Solution .5

62190-30 ANTIBLU MC-30 Arch Wood

Protection, Inc. Emulsifiable

Concentrate 14.7

64715-1 VEDEXIL-DM/K Lamirsa

Laboratories

Miret S.A. Technical

Chemical 98.95

# Docket Number: EPA-HQ-OPP-2011-0613

www.regulations.gov

18 of 50 Registration

No. Registration

Name Company

Name Formulation

Type % of Active

Ingredient

67869-17 N-948 TECHNICAL Verichem, Inc. Technical

Chemical 99

67869-31 N-948 WB Verichem, Inc. Soluble

Concentrate/

Solid 10

73612-1 SENTRY Chemcolour

Industries (NZ)

Ltd. Soluble

Concentrate 6.42

74655-4 SPECTRUM RX-32 Hercules

Incorporated Ready-to-Use

Solution 7

74655-6 SPECTRUM RX-38 Hercules

Incorporated Ready-to-Use

Solution 5

74655-7 SPECTRUM RX-31 Hercules

Incorporated Ready-to-Use

Solution 5

84377-1 BELLICIDE Bell Performance

Inc Flowable

Concentrate 2.5

# Docket Number: EPA-HQ-OPP-2011-0613

www.regulations.gov

19 of 50 III. Summary of Anticipated Data Requi rements – Methylene Bis(Thiocyanate)

The table below summarizes anticipated data needs for the Methylene Bis(Thiocyanate) Case in

Section I of this document (Preliminary Work Plan), Product Chemistry, Environmental Fate,

and Ecological Effects Scoping Document in Su pport of Registration Review of Methylene

bis(thiocyanate) , and Methylene Bis Thiocyanate (MBT): Human Health Risk Assessment

Scoping Document in Support of Registration Review

.

Table 2. Summary of Anticipated Data Re quirements – Methylene (Bis)Thiocyanate

Guideline

Number Anticipated Data Requirement Test

Material Estimated

Timeframe

(Measured

in months

from DCI

Receipt)

875.1700 Product use information (handler) TGAI 12

875.2700 Product use information (postapplication) TGAI 12

875.2800 Description of human activity TGAI 12

875.1200 Dermal indoor exposure TGAI 24

875.1400 Inhalation indoor exposure TGAI 24

875.1600 Application exposure data reporting and calculations TGAI 24

875.2900 Data reporting and calculations TGAI 24

875.2500 Inhalation Exposure TGAI 24

875.2300 Indoor Surface Residue Dissipation 3 

# TGAI 24

835.2240 

# Photodegradation in water (at pH 5) TGAI 12

835.1240 Adsorption/Desorption Study TGAI 12

835.4300 Aerobic Aquatic Metabolism Study TGAI 12

835.4300 Anaerobic Aquatic Metabolism Study TGAI 12

850.6800 Modified activated sludge, respiration inhibition test 4 

# TGAI 12

3 

# The anticipated DCI will provide that a protocol must be submitted for review and approval by the Agency prior to

initiating this study.

4 

# The results of the Activated Sludge Respiration Inhibition Test (ASRI) that is expected to be required would

determine which of these three biodegradation tests would be anticipated to be required. If the ASRI test EC 50 

# is

less than or equal to 20 mg/L, then either the Biodegradation in Activated Sludge Study or Simulation Test –

Aerobic Sewage Treatment: A. Activated Sludge Units or the Porous Pot Test would be anticipated to be required.

If the ASRI test EC 50 

# is greater than 20 mg/L, then the applicant would choose to conduct either: (i) Ready

Biodegradability or (ii) Biodegradation in Activated Slu dge or Simulation Test – Aerobic Sewage Treatment: A.

Activated Sludge Units or the Porous Pot Test. If the antimicrobial passes the ready biodegradability study, then no

further testing would be expected to be required. If , however, the antimicrobial fails the ready biodegradability

# Docket Number: EPA-HQ-OPP-2011-0613

www.regulations.gov

20 of 50 835.3110 Ready Biodegradability 4 

# TGAI 12

835.3220 Porous Pot Test 4 

# TGAI 12

835.3240 Simulation Test – Aerobic Sewa ge Treatment: A. Activated

Sludge Units 4 

# TGAI 12

835.3280 Simulation Tests to Assess the Biodegradability of

Chemicals Discharged to Wastewater 4 

# TGAI 12

850.1400 Fish early-life stage toxic ity test (freshwater) TGAI 12

850.4400 Aquatic plant toxicology test using Lemna spp., Tier I TGAI 12

850.5400 Algal Toxicity Tier I and Tier II TGAI 12

850.3020 Honey bee acute contact toxicity TGAI 12

850.3030 Honey bee toxicity of residues on foliage TGAI 12

850.1735 Whole sediment acute toxicity invertebrates (freshwater) 5 

# TGAI 12

850.1740 Whole sediment acute toxicity invertebrates (marine) 5 

# TGAI 12

Special Study Chronic sediment toxicity test (freshwater invertebrate) 5 

# TGAI 12

study, then the Biodegradation in Activated Sludge or Simulation Test – Aerobic Sewage Treatment: A. Activated

Sludge Units, or the Porous Pot study would be expected to be required.

5 

# If the environmental fate data anticipated as being requi red for this registration review demonstrate that the halflife of the MBT in the sediment is greater than 10 days and if any one of the following conditions are met (1) Kd

<50, (2) Koc <1000, or (3) Kow <3, then the registrant may request that the Agency waive the sediment studies.IV. Appendix A: Use Patterns– Methylene bis(thiocyanate)EPAReg #Formulation%A. I. Use Site Treatment Site/SurfacesApplicationMethodMin AppRateMax AppRate UnitsUseLimitations1022-583EmulsifiableConcentrate 14.71448-34Ready-toUse Solution 10.0Industrialprocesses andwater systems Pulp and paper mill systems Metered 0.1 lbs/ton0.5-1.5lbs/ton lbs/ton1448-34Ready-toUse Solution 10.0Industrialprocesses andwater systemsAlum solutions, animal gluesolutions, pigment slurries,coating formulations, andstarch slurries and solutions Metered 50 ppm 400 ppm PPM1448-34Ready-toUse Solution 10.0Industrialprocesses andwater systemsIndustrial recirculatingcooling water systems.Openpour/meteringpump0.7-5.5lbs/1000 galwater(5-40 ppm)3.4-6.8lbs/1000 galwater(25-50 ppm) lbs/gal1448-34Ready-toUse Solution 10.0Industrialprocesses andwater systemsRetort systems andpasteurizers Metered2.0 floz/1000 galwater4.8-8.0 floz/1000 galwater oz/gal1448-34Ready-toUse Solution 10.0Industrialprocesses andwater systems Drilling Muds and fluids Metered 0.05% 0.28%weight/weightDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov22 of 501448-34Ready-toUse Solution 10.0Industrialprocesses andwater systemsPetroleum secondary oilrecovery Metered0.2-0.6 floz/1000 galwater1.3-4.0 floz/1000 gal oz/gal1448-34Ready-toUse Solution 10.0Industrialprocesses andwater systemsCrude and refined oils suchas olefinic, aromatic,paraffinic and naphthenicoils. Metered0.6 floz/1000 gal6.6 fl oz/1000gal oz/gal1448-34Ready-toUse Solution 10.0MaterialsPreservativePigment slurries, adhesivescoatings and ink Metered 0.20% 0.5-2.0%weight/weight1448-34Ready-toUse Solution 10.0MaterialsPreservativeSolutions, emulsions,adhesives and other aqueousliquid products Incorporation 75 ppm 200 ppm PPM1448-34Ready-toUse Solution 10.0Industrialprocesses andwater systems Air washer Systems Metered0.01gal/1000 galof fluid10 ppm0.04 gal/1000gal of fluid40 ppm Gal/Gal1448-34Ready-toUse Solution 10.0MaterialsPreservativeLeather, brine cured hidesand skins Metered0.003%(30 ppm)0.02%(200 ppm)weight/weight1448-34Ready-toUse Solution 10.0MaterialsPreservative Metalworking Fluids Incorporation0.10gal/1000 galof fluid100 ppm0.40 gal/1000gal of fluid400 ppm Gal/GalDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov23 of 501448-80TechnicalChemical 99.0 For formulating use only.1448-81Ready-toUse Solution 10.0WoodPreservativeSapstain and mold onfreshly cut hardwood andsoftwood lumber, logs,poles, posts and timbers Immersion5 lbs/100 galwater18 lbs/100 galwater lbs/gal1448-81Ready-toUse Solution 10.0Industrialprocesses andwater systems Paper mill systems Metered0.1 lbs/tondry basis0.5-1.5lbs/ton drybasislbs/ton1448-81Ready-toUse Solution 10.0Industrialprocesses andwater systems Pulp Mills Spray0.5 lbs/tondry basis2.0-4.0lbs/ton drybasis1448-81Ready-toUse Solution 10.0Industrialprocesses andwater systemsAlum solutions, animal gluesolutions, pigment slurries,coating formulations, andstarch slurries and solutions Metered 50 ppm 400 ppm lbs/gal1448-81Ready-toUse Solution 10.0MaterialsPreservative Particle Board Metered 0.10% 0.30%weight/weight1448-81Ready-toUse Solution 10.0MaterialsPreservative Bacteriostatic Paper Metered 0.50% 9.00%weight/weightDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov24 of 501448-81Ready-toUse Solution 10.0MaterialsPreservative Cooling Tower woodOpenpour/meteringpump0.5%0.6 lbs/1000ft^20.7%0.8lbs/1000ft^2weight/weightLbs/Ft^21448-81Ready-toUse Solution 10.0Industrialprocesses andwater systemsIndustrial recirculatingcooling water systems.Openpour/meteringpump0.2-0.6lbs/1000 galwater1.2-3.7lbs/1000 galwater lbs/gal1448-81Ready-toUse Solution 10.0Industrialprocesses andwater systemsDrilling Muds and workoveror completeion fluids Metered 0.05% 0.25%weight/weight1448-81Ready-toUse Solution 10.0Industrialprocesses andwater systemsPetroleum secondary oilrecovery Metered3.9 floz/1000 galwater13.0 floz/1000 galwater oz/gal1448-81Ready-toUse Solution 10.0MaterialsPreservativeCrude and refined oils suchas olefinic, aromatic,paraffinic and naphthenicoils. Metered0.6 floz/1000 galwater6.0 fl oz/1000gal water oz/gal1448-81Ready-toUse Solution 10.0MaterialsPreservativeLeather, brine cured hidesand skins Metered0.003%30 ppm0.02%200 ppm PPM1448-81Ready-toUse Solution 10.0MaterialsPreservativeLeather, pickled, vegetable,chrome, alternative metal ormetal free tanned hides andskins Metered0.02%200 ppm0.05-0.25%(500-2500ppm)weight/weightDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov25 of 501448-81Ready-toUse Solution 10.0MaterialsPreservativepigment slurries, coatings,caulks, sealants andadhesives Metered 0.5-0.75% 2.5-9.0%weight/weight1448-102SolubleConcentrate 02.5WoodPreservativeSapstain and mold onfreshly cut hardwood andsoftwood lumber, logs,poles, posts and timbers Immersion12 lbs/100gal water96 lbs/100 galwater lbs/gal1448-102SolubleConcentrate 02.5Industrialprocesses andwater systems Paper mill systems Metered0.4 lbs/tondry basis2.0 lbs/tondry basislbs/ton1448-102SolubleConcentrate 02.5MaterialsPreservative Cooling Tower woodOpenpour/meteringpump2.0%2.4 lbs/1000ft^22.8%3.2lbs/1000ft^2weight/weightLbs/Ft^21448-102SolubleConcentrate 02.5Industrialprocesses andwater systemsIndustrial recirculatingcooling water systems.Openpour/meteringpump0.8-2.4lbs/1000 galwater4.8-14.8lbs/1000 galwater lbs/gal1448-102SolubleConcentrate 02.5Industrialprocesses andwater systemsDrilling Muds and workoveror completeion fluids Metered 0.20% 1.00%weight/weight1448-102SolubleConcentrate 02.5Industrialprocesses andwater systemsPetroleum secondary oilrecovery Metered15.6 floz/1000 galwater52.0 floz/1000 galwater oz/galDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov26 of 501448-102SolubleConcentrate 02.5MaterialsPreservative Fuel Oil Metered1.25 floz/100 gal2.5 fl oz/100gal Oz./Gal1448-102SolubleConcentrate 02.5MaterialsPreservativeCrude and refined oils suchas olefinic, aromatic,paraffinic and naphthenicoils. Metered2.4 floz/1000 galwater24.0 floz/1000 galwater oz/gal1448-102SolubleConcentrate 02.5MaterialsPreservative Leather, Hides and Skins Metered1.2lbs/1000lbs8.0lbs/1000lbs Lbs/lbs1448-102SolubleConcentrate 02.5MaterialsPreservativeLeather, pickled, vegetable,chrome, alternative metal ormetal free tanned hides andskins Metered2.0lbs/1000lbs10.0lbs/1000lbsweight/weight1448-102SolubleConcentrate 02.5MaterialsPreservative Coatings Metered 2.00% 36.00%weight/weight1448-147Ready-toUse Solution 10.0MaterialsPreservative Cooling Tower woodOpenpour/meteringpump0.5%0.6 lbs/1000ft^20.7%0.8lbs/1000ft^2weight/weightLbs/Ft^21448-147Ready-toUse Solution 10.0Industrialprocesses andwater systemsIndustrial recirculatingcooling water systems.Openpour/meteringpump0.2-0.6lbs/1000 galwater1.2-3.7lbs/1000 galwater lbs/galDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov27 of 501448-147Ready-toUse Solution 10.0Industrialprocesses andwater systemsDrilling Muds and workoveror completeion fluids Metered 0.05% 0.25%weight/weight1448-147Ready-toUse Solution 10.0Industrialprocesses andwater systemsPetroleum secondary oilrecovery Metered3.9 floz/1000 galwater13.0 floz/1000 galwater oz/gal1448-147Ready-toUse Solution 10.0MaterialsPreservative Fuel Oil Metered3.0 floz/1000 gal6.0 fl oz/1000gal Oz./Gal1448-147Ready-toUse Solution 10.0MaterialsPreservativeCrude and refined oils suchas olefinic, aromatic,paraffinic and naphthenicoils. Metered0.6 floz/1000 galwater6.0 fl oz/1000gal water oz/gal1448-148SolubleConcentrate 10.0MaterialsPreservative Cooling Tower woodOpenpour/meteringpump0.5%0.6 lbs/1000ft^20.7%0.8lbs/1000ft^2weight/weightLbs/Ft^21448-148SolubleConcentrate 10.0Industrialprocesses andwater systemsIndustrial recirculatingcooling water systems.Openpour/meteringpump0.2-0.6lbs/1000 galwater1.2-3.7lbs/1000 galwater lbs/gal1448-148SolubleConcentrate 10.0Industrialprocesses andwater systemsDrilling Muds and workoveror completeion fluids Metered 0.05% 0.25%weight/weightDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov28 of 501448-148SolubleConcentrate 10.0Industrialprocesses andwater systemsPetroleum secondary oilrecovery Metered3.9 floz/1000 galwater13.0 floz/1000 galwater oz/gal1448-148SolubleConcentrate 10.0MaterialsPreservative Fuel Oil Metered3.0 floz/1000 gal6.0 fl oz/1000gal Oz./Gal1448-148SolubleConcentrate 10.0MaterialsPreservativeCrude and refined oils suchas olefinic, aromatic,paraffinic and naphthenicoils. Metered0.6 floz/1000 galwater6.0 fl oz/1000gal water oz/gal1448-171Ready-toUse Solution 02.5MaterialsPreservative Cooling Tower woodOpenpour/meteringpump2.0%2.4 lbs/1000ft^22.8%3.2lbs/1000ft^2weight/weightLbs/Ft^21448-171Ready-toUse Solution 02.5Industrialprocesses andwater systemsIndustrial recirculatingcooling water systems.Openpour/meteringpump0.8-2.4lbs/1000 galwater4.8-14.8lbs/1000 galwater lbs/gal1448-171Ready-toUse Solution 02.5Industrialprocesses andwater systemsDrilling Muds and workoveror completeion fluids Metered 0.20% 1.00%weight/weight1448-171Ready-toUse Solution 02.5Industrialprocesses andwater systemsPetroleum secondary oilrecovery Metered15.6 floz/1000 galwater52.0 floz/1000 galwater oz/galDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov29 of 501448-171Ready-toUse Solution 02.5MaterialsPreservative Fuel Oil Metered1.25 floz/1000 gal2.5 fl oz/1000gal Oz./Gal1448-171Ready-toUse Solution 02.5MaterialsPreservativeCrude and refined oils suchas olefinic, aromatic,paraffinic and naphthenicoils. Metered2.4 floz/1000 galwater24.0 floz/1000 galwater oz/gal1448-172SolubleConcentrate 02.5MaterialsPreservative Cooling Tower woodOpenpour/meteringpump2.0%2.4 lbs/1000ft^22.8%3.2lbs/1000ft^2weight/weightLbs/Ft^21448-172SolubleConcentrate 02.5Industrialprocesses andwater systemsIndustrial recirculatingcooling water systems.Openpour/meteringpump0.8-2.4lbs/1000 galwater4.8-14.8lbs/1000 galwater lbs/gal1448-172SolubleConcentrate 02.5Industrialprocesses andwater systemsDrilling Muds and workoveror completeion fluids Metered 0.20% 1.00%weight/weight1448-172SolubleConcentrate 02.5Industrialprocesses andwater systemsPetroleum secondary oilrecovery Metered15.6 floz/1000 galwater52.0 floz/1000 galwater oz/gal1448-172SolubleConcentrate 02.5MaterialsPreservative Fuel Oil Metered1.25 floz/1000 gal2.5 fl oz/1000gal Oz./GalDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov30 of 501448-172SolubleConcentrate 02.5MaterialsPreservativeCrude and refined oils suchas olefinic, aromatic,paraffinic and naphthenicoils. Metered2.4 floz/1000 galwater24.0 floz/1000 galwater oz/gal1448-357Ready-toUse Solution 10.0Industrialprocesses andwater systemsDrilling Muds and workoveror completeion fluids Metered 0.05% 0.28%weight/weight1448-357Ready-toUse Solution 10.0Industrialprocesses andwater systemsPetroleum secondary oilrecovery Metered0.2-0.6 floz/1000 galwater1.3-4.0 floz/1000 galwater oz/gal1448-357Ready-toUse Solution 10.0MaterialsPreservativeCrude and refined oils suchas olefinic, aromatic,paraffinic and naphthenicoils. Metered0.6 floz/1000 galwater6.6 fl oz/1000gal water oz/gal1448-358Ready-toUse Solution 10.0Industrialprocesses andwater systemsIndustrial recirculatingcooling water systems.Openpour/meteringpump0.7-3.4lbs/1000 galwater(5-25 ppm)5.5-6.8lbs/1000 galwater(40-50 ppm) lbs/gal1448-358Ready-toUse Solution 10.0Industrialprocesses andwater systemsRetort systems andpasteurizers Metered2.0 floz/1000 galwater4.8-8.0 floz/1000 galwater oz/gal1448-359Ready-toUse Solution 10.0Industrialprocesses andwater systemsIndustrial recirculatingcooling water systems.Openpour/meteringpump0.7-3.4lbs/1000 galwater(5-25 ppm)5.5-6.8lbs/1000 galwater(40-50 ppm) lbs/galDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov31 of 501448-359Ready-toUse Solution 10.0Industrialprocesses andwater systemsRetort systems andpasteurizers Metered2.0 floz/1000 galwater4.8-8.0 floz/1000 galwater oz/gal1448-360Ready-toUse Solution 10.0MaterialsPreservativeCrude and refined oils suchas olefinic, aromatic,paraffinic and naphthenicoils. Metered0.6 floz/1000 galwater6.6 fl oz/1000gal water oz/gal1448-359Ready-toUse Solution 10.0Industrialprocesses andwater systemsIndustrial recirculatingcooling water systems.Openpour/meteringpump0.7-3.4lbs/1000 galwater(5-25 ppm)5.5-6.8lbs/1000 galwater(40-50 ppm) lbs/gal1448-359Ready-toUse Solution 10.0Industrialprocesses andwater systemsRetort systems andpasteurizers Metered2.0 floz/1000 galwater4.8-8.0 floz/1000 galwater oz/gal1448-375FormulationIntermediate 10.0 For formulating use only.1448-376WettablePowder 02.51448-376WettablePowder 02.5WoodPreservativeSapstain and mold onfreshly cut hardwood andsoftwood lumber, logs,poles, posts and timbers Immersion12 lbs/100gal water96 lbs/100 galwater lbs/galDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov32 of 501448-376WettablePowder 02.5Industrialprocesses andwater systems Paper mill systems Metered0.4 lbs/tondry basis2.0 lbs/tondry basislbs/ton1448-376WettablePowder 02.5MaterialsPreservative Cooling Tower woodOpenpour/meteringpump2.0%2.4 lbs/1000ft^22.8%3.2lbs/1000ft^2weight/weightLbs/Ft^21448-376WettablePowder 02.5Industrialprocesses andwater systemsIndustrial recirculatingcooling water systems.Openpour/meteringpump0.8-2.4lbs/1000 galwater4.8-14.8lbs/1000 galwater lbs/gal1448-376WettablePowder 02.5Industrialprocesses andwater systemsDrilling Muds and workoveror completeion fluids Metered 0.20% 1.00%weight/weight1448-376WettablePowder 02.5Industrialprocesses andwater systemsPetroleum secondary oilrecovery Metered15.6 floz/1000 galwater52.0 floz/1000 galwater oz/gal1448-376WettablePowder 02.5MaterialsPreservativeCrude and refined oils suchas olefinic, aromatic,paraffinic and naphthenicoils. Metered2.4 floz/1000 galwater24.0 floz/1000 galwater oz/gal1448-376WettablePowder 02.5MaterialsPreservative Leather, Hides and Skins Metered1.2lbs/1000lbs8.0lbs/1000lbs Lbs/lbsDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov33 of 501448-376WettablePowder 02.5MaterialsPreservativeLeather, pickled, vegetable,chrome, alternative metal ormetal free tanned hides andskins Metered2.0lbs/1000lbs10.0lbs/1000lbsweight/weight1448-376WettablePowder 02.5MaterialsPreservative Coatings Metered 2.00% 36.00%weight/weight1448-377Ready-toUse Solution 10.0WoodPreservativeSapstain and mold onfreshly cut hardwood andsoftwood lumber, logs,poles, posts and timbers Immersion5 lbs/100 galwater18 lbs/100 galwater lbs/gal1448-377Ready-toUse Solution 10.0Industrialprocesses andwater systems Pulp and paper mill systems Metered0.1 lbs/tondry basis50 ppm0.5 lbs/tondry basis400 ppmlbs/ton1448-377Ready-toUse Solution 10.0Industrialprocesses andwater systemsAlum solutions, animal gluesolutions, pigment slurries,coating formulations, andstarch slurries and solutions Metered6.9 lbs/1000gal water(82 ppm)37 lbs/1000gal water(444 ppm) lbs/gal1448-377Ready-toUse Solution 10.0MaterialsPreservative Particle Board Metered 0.10% 0.30%weight/weight1448-377Ready-toUse Solution 10.0MaterialsPreservative Bacteriostatic Paper Metered 0.50% 9.00%weight/weightDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov34 of 501448-377Ready-toUse Solution 10.0MaterialsPreservative Cooling Tower woodOpenpour/meteringpump0.5%0.6 lbs/1000ft^20.7%0.8lbs/1000ft^2weight/weightLbs/Ft^21448-377Ready-toUse Solution 10.0Industrialprocesses andwater systemsIndustrial recirculatingcooling water systems.Openpour/meteringpump0.2-0.6lbs/1000 galwater1.2-3.7lbs/1000 galwater lbs/gal1448-377Ready-toUse Solution 10.0Industrialprocesses andwater systemsDrilling Muds and workoveror completeion fluids Metered 0.05% 0.25%weight/weight1448-377Ready-toUse Solution 10.0Industrialprocesses andwater systemsPetroleum secondary oilrecovery Metered3.9 floz/1000 galwater13.0 floz/1000 galwater oz/gal1448-377Ready-toUse Solution 10.0MaterialsPreservativeCrude and refined oils suchas olefinic, aromatic,paraffinic and naphthenicoils. Metered0.6 floz/1000 galwater6.0 fl oz/1000gal water oz/gal1448-377Ready-toUse Solution 10.0MaterialsPreservativeLeather, brine cured hidesand skins Metered0.003%30 ppm0.02%200 ppm PPM1448-377Ready-toUse Solution 10.0MaterialsPreservativeLeather, pickled, vegetable,chrome, alternative metal ormetal free tanned hides andskins Metered0.02-0.05%200 ppm0.05-0.25%2500 ppmweight/weightDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov35 of 501448-408WettablePowder 08.0MaterialsPreservativepigment slurries, coatings,caulks, sealants andadhesives Metered 0.5-0.75% 2.5-9.0%weight/weight1448-408WettablePowder 08.0MaterialsPreservativeLeather, brine cured hidesand skinsPre-packagedwater solublebags8-16oz/1000 lbs40-48oz/1000 lbs oz/Gal1448-408WettablePowder 08.0MaterialsPreservativeLeather, pickled, vegetable,chrome, alternative metal ormetal free tanned hides andskinsPre-packagedwater solublebags8-16oz/1000 lbs32-48oz/1000 lbs oz/Gal1448-408WettablePowder 08.0Industrialprocesses andwater systemsAutomated cooling watersystems.Pre-packagedwater solublebags 30-60 ppm 120-240 ppm PPM1448-408WettablePowder 08.0Industrialprocesses andwater systems Cooling water systems.Pre-packagedwater solublebagsOne lb bag:16 oz/2000-4000 galwater4 oz bag: 4oz/500-1000gal of waterOne lb bag:32-64oz/2000-4000gal water4 oz bag: 8-16 oz/500-1000 gal ofwater oz/Gal1448-408WettablePowder 08.0Industrialprocesses andwater systemsPetroleum secondary oilrecoveryPre-packagedwater solublebags4-16oz/1000 gal16-64oz/1000 gal oz/Gal1448-408WettablePowder 08.0Industrialprocesses andwater systemsDrilling Muds and workoveror completeion fluidsPre-packagedwater solublebags64 oz/1000gal384 oz/1000gal oz/GalDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov36 of 501448-408WettablePowder 08.0WoodPreservativeSapstain and mold onfreshly cut hardwood andsoftwood lumber, logs,poles, posts and timbersPre-packagedwater solublebags, spray,dip96 oz/100gal384 oz/100gal oz/Gal1448-435SolubleConcentrate/Solid 10.0Industrialprocesses andwater systems Air washer Systems Metered0.12lbs/1000 galwater(1.4 ppm)0.90 lbs/1000gal of water(10.8 ppm) lbs/Gal1448-435SolubleConcentrate/Solid 10.0Industrialprocesses andwater systemsIndustrial recirculatingcooling water systems. Metered0.30-0.40lbs/1000 galwater(3.6-4.6ppm)0.90-1.86lbs/1000 galwater(11-22 ppm) lbs/gal1448-435SolubleConcentrate/Solid 10.0Industrialprocesses andwater systems Pulp and paper mill systems Metered0.14 lbs/tondry basis7 ppm0.36 lbs/tondry basis18 ppmlbs/ton1448-435SolubleConcentrate/Solid 10.0Industrialprocesses andwater systems Paper additives Metered6.9 lbs/1000gal water(82 ppm)37 lbs/1000gal water(444 ppm) lbs/gal1448-435SolubleConcentrate/Solid 10.0Industrialprocesses andwater systems Brewery Pasteurizers Metered0.092-0.19lbs/1000 galwater(1.1-2.3ppm)0.37-0.84lbs/1000 galwater(4.4-10 ppm) lbs/gal1448-435SolubleConcentrate/Solid 10.0Industrialprocesses andwater systemsDrilling Muds and workoveror completeion fluids Metered0.2 gal/100barrels(4.1 ppm)4.0 gal/100barrels(83 ppm) gal/barrelDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov37 of 501448-435SolubleConcentrate/Solid 10.0Industrialprocesses andwater systems Hydrotesting Metered0.1 gal/1000gal of water(11 ppm)40 gal/1000gal of water(4400 ppm) gal/gal1448-435SolubleConcentrate/Solid 10.0MaterialsPreservative Adheisves and emulsions Metered6.9 lbs/1000gal water(82ppm)37 lbs/1000gal water(444ppm) lbs/gal1448-435SolubleConcentrate/Solid 10.0MaterialsPreservative Construction Products Metered6.9 lbs/1000gal water(82 ppm)37 lbs/1000gal water(444 ppm) lbs/gal1448-435SolubleConcentrate/Solid 10.0MaterialsPreservativeCrude oil, diesel fuel,residual fuel oils, coalslurries, liquified petroleumgases and pertochemicalfeedstocks Metered32 floz/10000 galfluid(2.5 ppm)64-128 floz/10000 galfluid(5.0-10.0ppm) oz/gal1448-435SolubleConcentrate/Solid 10.0MaterialsPreservativeLeather, pickled, vegetable,chrome, alternative metal ormetal free tanned hides andskins Metered 0.025% 0.25%weight/weight1448-435SolubleConcentrate/Solid 10.0MaterialsPreservative Metalworking Fluids Metered6.9 lbs/1000gal water(82 ppm)37 lbs/1000gal water(444 ppm) lbs/gal1448-435SolubleConcentrate/Solid 10.0MaterialsPreservativePaints, coatings and stains.Pigments, dyes and fillersuspensions. Polymerdispersions and emulsions. Metered6.9 lbs/1000gal water(82 ppm)69 lbs/1000gal water(827 ppm) lbs/galDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov38 of 501448-435SolubleConcentrate/Solid 10.0MaterialsPreservative Textiles Metered6.9 lbs/1000gal water(82 ppm)69 lbs/1000gal water(827 ppm) lbs/gal1448-438EmulsifiableConcentrate 10.0WoodPreservativeSapstain and mold onfreshly cut hardwood andsoftwood lumber, logs,poles, posts and timbers Immersion0.50gal/1000 galof fluid2.0 gal/1000gal of fluid Gal/Gal1448-439SolubleConcentrate 10.0WoodPreservativeSapstain and mold onfreshly cut hardwood andsoftwood lumber, logs,poles, posts and timbers Immersion0.50gal/1000 galof fluid2.0 gal/1000gal of fluid Gal/Gal1448-439SolubleConcentrate 10.0Industrialprocesses andwater systems Pulp and paper mill systems Metered 0.1 lbs/ton0.5-1.5lbs/ton lbs/ton1448-439SolubleConcentrate 10.0MaterialsPreservativeAlum solutions, animal gluesolutions, pigment slurries,coating formulations, andstarch slurries and solutions Metered 50 ppm 400 ppm PPM1448-439SolubleConcentrate 10.0MaterialsPreservative Pulp MillsMeteredspray0.5 lbs/tondry pulp1.5-4.0lbs/ton drypulp lbs/ton1448-439SolubleConcentrate 10.0MaterialsPreservative Particle Board Metered 0.10% 0.30%weight/weightDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov39 of 501448-439SolubleConcentrate 10.0MaterialsPreservative Bacteriostatic Paper Metered 0.50% 0.90%weight/weight1448-439SolubleConcentrate 10.0Industrialprocesses andwater systems Cooling Tower woodOpenpour/meteringpump0.5%0.6lbs/1000ft^20.7%0.8lbs/1000ft^2weight/weightLbs/Ft^21448-439SolubleConcentrate 10.0Industrialprocesses andwater systemsIndustrial recirculatingcooling water systems.Openpour/meteringpump0.2-0.6lbs/1000 galwater1.2-3.7lbs/1000 galwater1448-439SolubleConcentrate 10.0Industrialprocesses andwater systemsDrilling Muds and workoveror completeion fluids Metered 0.05% 0.25%weight/weight1448-439SolubleConcentrate 10.0Industrialprocesses andwater systemsPetroleum secondary oilrecovery Metered3.9 floz/1000 galwater13.0 floz/1000 galwater oz/gal1448-439SolubleConcentrate 10.0MaterialsPreservativeCrude and refined oils suchas olefinic, aromatic,paraffinic and naphthenicoils. Metered0.6 floz/1000 galwater6.0 fl oz/1000gal water oz/gal1448-439SolubleConcentrate 10.0MaterialsPreservativePigment slurries, coatings,wood stains, caulks, sealantsand adhesives Metered 0.50% 0.75%-9.0%weight/weightDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov40 of 501448-439SolubleConcentrate 10.0MaterialsPreservativeLeather, brine cured hidesand skins Metered0.003%(30 ppm)0.02%(200 ppm)weight/weight1448-439SolubleConcentrate 10.0MaterialsPreservativeLeather, pickled, vegetable,chrome, alternative metal ormetal free tanned hides andskins Metered0.02-0.05%(200-500ppm)0.075-0.25%(750-2500ppm)weight/weight1706-112Ready-toUse Solution 10.0MaterialsPreservative Fuel Oil Storage Tanks Metered 25 ppm 50-100 ppm PPM1706-112Ready-toUse Solution 10.0Industrialprocesses andwater systems Pulp and paper mill systems Metered 0.05 lbs/ton0.05-1.0lbs/ton lbs/ton1706-112Ready-toUse Solution 10.0MaterialsPreservativeAqueous solutions and otherliquid products Incorporation 75 ppm 750 ppm PPM1706-200Ready-toUse Solution 10.0Industrialprocesses andwater systems Pulp and paper mill systems Metered1.09 floz/1000 galwater10.9 floz/1000 galwater oz/gal1706-200Ready-toUse Solution 10.0MaterialsPreservative Adheisves and emulsions Incorporation0.2 lbs/1000lbs2.0 lbs /1000lbs Lbs/lbsDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov41 of 501706-200Ready-toUse Solution 10.0MaterialsPreservativeMineral slurries such askaolin, calcium carbonate,titanium dioxide and otheraqueous dispersions Incorporation 0.002% 0.02%weight/weight1706-200Ready-toUse Solution 10.0MaterialsPreservativeAqueous solutions and otherliquid products Incorporation 75 ppm 750 ppm PPM3876-121Ready-toUse Solution 05.0Industrialprocesses andwater systemsIndustrial recirculatingcooling water systems. Metered12-24 ppm0.1-0.2lbs/1000 galwater90-120 ppm0.75-1.0lbs/1000 galwater3876-121Ready-toUse Solution 05.0Industrialprocesses andwater systems Air washer Systems Metered12-24 ppm0.1-0.2lbs/1000 galwater90-120 ppm0.75-1.0lbs/1000 galwater8622-42TechnicalChemical 99.0FOR USE BYMANUFACTURERSONLY INFORMULATINGMICROBIOCIDES FORUSE IN INDUSTRIALCOOLING WATERSYSTEMS AND PAPERMILLS.9386-4Ready-toUse Solution 10.0Industrialprocesses andwater systemsIndustrial recirculatingcooling water systems. Metered1.6-5.8 floz/1000 gal(1.25-4.5ppm)7.9-12.5 floz/1000 gal(6.2-9.8 ppm) fl oz/Gal9386-4Ready-toUse Solution 10.0Industrialprocesses andwater systems Pulp and paper mill systems Metered2.-3.5 floz/ton (drybasis)4.0-5.0 floz/ton (drybasis) fl oz/tonDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov42 of 509386-4Ready-toUse Solution 10.0Industrialprocesses andwater systemsDrilling Muds and workoveror completeion fluidsMetered/openpour1.75lbs/barrel5000 PPM Lbs/barrel9386-4Ready-toUse Solution 10.0Industrialprocesses andwater systemsOil-field water, and otheroil-field Water systemsMetered/openpour0.50gal/1000 galof fluid500 ppm0.75 gal/1000gal of fluid750 ppm Gal/Gal9386-4Ready-toUse Solution 10.0MaterialsPreservative Leather, Hides and Skins Metered0.25lbs/1000lbs2.5lbs/1000lbs Lbs/lbs9386-12TechnicalChemical 99.0For formulating andcompounding products foruse in papermill systems,cooling water systems,secondary oil recovery andas a preservative ofsolutions, emulsions andother non-food liquidproducts.9386-26Ready-toUse Solution 10.0Industrialprocesses andwater systemsIndustrial recirculatingcooling water systems. Metered1.6-5.8 floz/1000 gal(1.25-4.5ppm)7.9-12.5 floz/1000 gal(6.2-9.8 ppm) fl oz/Gal9386-26Ready-toUse Solution 10.0Industrialprocesses andwater systems Pulp and paper mill systems Metered2.-3.5 floz/ton (drybasis)4.0-5.0 floz/ton (drybasis) fl oz/ton9386-26Ready-toUse Solution 10.0Industrialprocesses andwater systemsDrilling Muds and workoveror completeion fluids Metered1.75lbs/barrel5000 PPM Lbs/barrelDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov43 of 509386-26Ready-toUse Solution 10.0Industrialprocesses andwater systemsOil-field water, and otheroil-field Water systems Metered0.50gal/1000 galof fluid500 ppm0.75 gal/1000gal of fluid750 ppm Gal/Gal9386-26Ready-toUse Solution 10.0MaterialsPreservativeSolutions, emulsions,adhesives and other aqueousliquid products Incorporation 75 ppm 750 ppm PPM9386-26Ready-toUse Solution 10.0MaterialsPreservative Metalworking Fluids Incorporation0.10gal/1000 galof fluid100 ppm0.40 gal/1000gal of fluid400 ppm Gal/Gal9386-26Ready-toUse Solution 10.0MaterialsPreservativeCrude oil, diesel fuel,residual fuel oils, coalslurries, liquified petroleumgases and pertochemicalfeedstocks Metered 25 ppm 50-100 ppm PPM9386-31Ready-toUse Solution 10.0Industrialprocesses andwater systemsIndustrial recirculatingcooling water systems. Metered1.6-5.8 floz/1000 gal(1.25-4.5ppm)7.9-12.5 floz/1000 gal(6.2-9.8 ppm) fl oz/Gal9386-31Ready-toUse Solution 10.0Industrialprocesses andwater systems Air washer Systems Metered0.01gal/1000 galof fluid10 ppm0.04 gal/1000gal of fluid40 ppm Gal/Gal9386-31Ready-toUse Solution 10.0Industrialprocesses andwater systems Brewery Pasteurizers Metered0.01-0.02gal/1000 galof fluid10-20 ppm0.03-0.04gal/1000 galof fluid30-40 ppm Gal/GalDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov44 of 509386-31Ready-toUse Solution 10.0Industrialprocesses andwater systems Pulp and paper mill systems Metered2.-3.5 floz/ton (drybasis)4.0-5.0 floz/ton (drybasis) fl oz/ton9386-31Ready-toUse Solution 10.0MaterialsPreservativeSolutions, emulsions,adhesives and other aqueousliquid products Incorporation 75 ppm 750 ppm PPM9386-31Ready-toUse Solution 10.0MaterialsPreservative Metalworking Fluids Incorporation0.10gal/1000 galof fluid100 ppm0.40 gal/1000gal of fluid400 ppm Gal/Gal9386-31Ready-toUse Solution 10.0MaterialsPreservativeCrude oil, diesel fuel,residual fuel oils, coalslurries, liquified petroleumgases and pertochemicalfeedstocks Incorporation 25 ppm 50-100 ppm PPM33677-1TechnicalChemical 99.0For formulation of industrialmicrobicides andpreservatives.47091-12Ready-toUse Solution 10.0MaterialsPreservative Metalworking Fluids Metered0.1 gal/1000gal of fluid100 ppm0.4 gal/1000gal of fluid400 ppm47091-12Ready-toUse Solution 10.0Industrialprocesses andwater systems Brewery Pasteurizers Metered2-4 oz/1000gal of water6 oz/1000 galof waterDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov45 of 5047091-12Ready-toUse Solution 10.0Industrialprocesses andwater systems Air washer Systems Metered0.01gal/1000 galof fluid10 ppm0.04 gal/1000gal of fluid40 ppm56156-1Ready-toUse Solution 00.5WoodPreservativeSeasoned and UnseasonedWood, sapstain andremedial Brush/spray75-100ft^2/gal24hrs dry timebetweencoats150-200ft^2/galApplyas much asthe wood willabsorb62190-30EmulsifiableConcentrate 14.7WoodPreservativeUnseasoned wood sapstaincontrol Dip/Spray1/2 gal/100gal water(dip)1/4 gal/100gal water(spray)2 gal/100 galwater (dip)1 gal/20 galwater (spray) Gal/Gal64715-1TechnicalChemical 99.0For use by manufacturersonly in formulatingindustrial microbiocides andpreservatives.67869-17TechnicalChemical 99.0Only for formulation into anend use product for use inindustrial process and watersystems and materialspreservatives67869-31SolubleConcentrate/Solid 10.0Industrialprocesses andwater systems Air washer Systems Metered0.12lbs/1000 galwater(1.4 ppm)0.90 lbs/1000gal of water(10.8 ppm) lbs/gal67869-31SolubleConcentrate/Solid 10.0Industrialprocesses andwater systemsIndustrial recirculatingcooling water systems. Metered0.30-0.40lbs/1000 galwater(3.6-4.6ppm)0.90-1.86lbs/1000 galwater(11-22 ppm) lbs/galDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov46 of 5067869-31SolubleConcentrate/Solid 10.0Industrialprocesses andwater systems Pulp and paper mill systems Metered0.14 lbs/tondry basis7 ppm0.36 lbs/tondry basis18 ppmlbs/ton67869-31SolubleConcentrate/Solid 10.0MaterialsPreservativePulp, pigment slurries,alum, emulsions, adhesives,deloarners, polymers andpaper products. Metered6.9 lbs/1000gal water(82 ppm)69 lbs/1000gal water(827 ppm) lbs/gal67869-31SolubleConcentrate/Solid 10.0Industrialprocesses andwater systems Brewery Pasteurizers Metered0.30-0.40lbs/1000 galwater(3.6-4.6ppm)0.90-1.86lbs/1000 galwater(11-22 ppm) lbs/gal67869-31SolubleConcentrate/Solid 10.0Industrialprocesses andwater systemsDrilling Muds and workoveror completeion fluids Metered0.2 gal/100barrels(4.1 ppm)4.0 gal/100barrels(83 ppm) gal/barrel67869-31SolubleConcentrate/Solid 10.0Industrialprocesses andwater systems Hydrotesting Metered0.1 gal/1000gal of water(11 ppm)40 gal/1000gal of water(4400 ppm) gal/gal67869-31SolubleConcentrate/Solid 10.0MaterialsPreservative Adheisves and emulsions Metered6.9 lbs/1000gal water(82 ppm)69 lbs/1000gal water(827 ppm) lbs/gal67869-31SolubleConcentrate/Solid 10.0MaterialsPreservative Construction Products Metered6.9 lbs/1000gal water(82 ppm)69 lbs/1000gal water(827 ppm) lbs/galDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov47 of 5067869-31SolubleConcentrate/Solid 10.0MaterialsPreservativeCrude oil, diesel fuel,residual fuel oils, coalslurries, liquified petroleumgases and pertochemicalfeedstocks Metered32 floz/10000 galfluid(2.5 ppm)64-128 floz/10000 galfluid(5.0-10.0ppm) oz/gal67869-31SolubleConcentrate/Solid 10.0MaterialsPreservative Leather, Hides and Skins Metered 0.025% 0.25%weight/weight67869-31SolubleConcentrate/Solid 10.0MaterialsPreservative Metalworking Fluids Metered6.9 lbs/1000gal water(82 ppm)37 lbs/1000gal water(444 ppm) lbs/gal67869-31SolubleConcentrate/Solid 10.0MaterialsPreservativePaints, coatings and stains.Pigments, dyes and fillersuspensions. Polymerdispersions and emulsions. Metered6.9 lbs/1000gal water(82 ppm)69 lbs/1000gal water(827 ppm) lbs/gal67869-31SolubleConcentrate/Solid 10.0MaterialsPreservative Textiles Metered6.9 lbs/1000gal water(82 ppm)69 lbs/1000gal water(827 ppm) lbs/gal73612-1SolubleConcentrate 06.4WoodPreservativeUnseasoned wood sapstaincontrol Spray40 L/1000 Lwater180 L/1000 Lwater Liter/Liter74655-4Ready-toUse Solution 07.0Industrialprocesses andwater systems Pulp and paper mill systems Metered12 ppm0.1 lbs/1000gal water90-120 ppm0.75-1.0lbs/1000 galwaterPPMlbs/GalDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov48 of 5074655-4Ready-toUse Solution 07.0MaterialsPreservativePulp, pigment slurries,alum, emulsions, adhesives,deloarners, polymers andpaper products. Metered200-250ppm800-1000ppm PPM74655-6Ready-toUse Solution 05.0Industrialprocesses andwater systems Pulp and paper mill systems Metered12-24 ppm0.1-0.2lbs/1000 galwater36-120 ppm0.3-1.0lbs/1000 galwaterPPMlbs/Gal74655-6Ready-toUse Solution 05.0MaterialsPreservativePulp, pigment slurries,alum, emulsions, adhesives,deloarners, polymers andpaper products. Metered200-250ppm800-1000ppm PPM74655-7Ready-toUse Solution 05.0Industrialprocesses andwater systems Pulp and paper mill systems Metered12-60 ppm0.1-0.5lbs/1000 galwater180-480 ppm1.5-4.0lbs/1000 galwaterPPMlbs/Gal74655-7Ready-toUse Solution 05.0MaterialsPreservative Paper and Paperboard Metered5.0 lb/ton200 ppm20.0 lbs /ton1000 ppmlbs./tonPPM74655-7Ready-toUse Solution 05.0MaterialsPreservativePulp, pigment slurries,alum, emulsions, adhesives,deloarners, polymers andpaper products. Metered200-250ppm800-1000ppm PPM81910-4EmulsifiableConcentrate 10.0Industrialprocesses andwater systemsIndustrial recirculatingcooling water systems. Metered0.2-0.6 floz/1000 galwater1.2-3.7 floz/1000 galwater Oz./GalDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov49 of 5081910-4EmulsifiableConcentrate 10.0Industrialprocesses andwater systems Drilling Muds and fluids Metered10.0 floz/ton 70.0 fl oz/ton Oz./ton81910-4EmulsifiableConcentrate 10.0Industrialprocesses andwater systemsOil-field water, and otheroil-field Water systems Metered4.0floz/1000 galwater13.0 floz/1000 galwater Oz./Gal81910-4EmulsifiableConcentrate 10.0MaterialsPreservative Leather, Hides and Skins Metered 5.0 fl oz/ton200.0 floz/ton Oz./ton81910-4EmulsifiableConcentrate 10.0MaterialsPreservativeLeather, Hides and Skins,Brine cured ONLY Metered 30 ppm 200 ppm PPM81910-4EmulsifiableConcentrate 10.0Industrialprocesses andwater systems Pulp and paper mills Metered 0.05 lb/ton 2.0 lbs /ton lbs./ton81910-4EmulsifiableConcentrate 10.0MaterialsPreservative Particle Board Incorporation 0.10% 1.00%weight/weight81910-4EmulsifiableConcentrate 10.0MaterialsPreservativePigment slurries, coatings,wood stains, caulks, sealantsand adhesives Metered 3/4 gal/ton 10 gal/ton Gal/tonDocket Number: EPA-HQ-OPP-2011-0613www.regulations.gov50 of 5084377-1FlowableConcentrate 02.5Industrialprocesses andwater systems Cooling Tower woodOpenpour/meteringpump2.4 lbs/1000ft^23.2lbs/1000ft^2 Lbs/Ft^284377-1FlowableConcentrate 02.5Industrialprocesses andwater systemsIndustrial recirculatingcooling water systems.Openpour/meteringpump0.8-2.4 floz/1000 galwater4.8-14.8 floz/1000 galwater Oz./Gal84377-1FlowableConcentrate 02.5Industrialprocesses andwater systems Drilling MudsOpenpour/meteringpump 0.20% 1.00%weight/weight84377-1FlowableConcentrate 02.5Industrialprocesses andwater systemsOil-field water, polymer, ormicellar floods, waterdisposal systems, and otheroil-field Water systems Metered15.6 floz/1000 galwater52.0 floz/1000 gal Oz./Gal84377-1FlowableConcentrate 02.5MaterialsPreservativeCrude and refined oils suchas olefinic, aromatic,paraffinic and naphthenicoils.Openpour/meteringpump2.4 floz/1000 gal24.0 floz/1000 gal Oz./Gal84377-1FlowableConcentrate 02.5MaterialsPreservative Fuel Oil Metered0.25-0.5 floz/100 gal1.25-2.5 floz/100 gal Oz./Gal