# FIFRA Scientific Advisory Panel Meeting Integrated Bioactivity and Exposure Ranking: A Computational Approach for the Screening of Chemicals in the 

# Endocrine Disruptor Screening Program

Arlington, VA December 2 - 5, 2014
Slide 1 of 7

# Presentation Roadmap

Introduction Estrogen Receptor Bioactivity Androgen Receptor Bioactivity Exposure

Toxicokinetics/Dosimetry

Integrated Bioactivity Exposure Ranking

Future Directions FIFRA SAP: Integrated Bioactivity Exposure Ranking Dec 2 - 5, 2014 Slide 2 of 7

# Endocrine Disruptor Screening Program (EDSP)

 Established in 1998  Protection of human health and wildlife  Includes estrogen, androgen and thyroid pathways 

#  Approach • Prioritization based on exposure and bioactivity • Screening for bioactivity • Testing for dose - response and adverse effects

Prioritization Bioactivity/ Exposure 

### Screening Bioactivity 

### Testing Dose - Response/Adversity More chemicals Fewer chemicals

FIFRA SAP: Integrated Bioactivity Exposure Ranking Dec 2 - 5, 2014 Slide 3 of 7

# EDSP Prioritization, Screening & Testing

Prioritization Bioactivity/Exposure Screening Bioactivity Testing Dose Response/Adversity

Relies on: 

### • QSARs • ToxCast/ExpoCast • Monitoring data • OSRI Relies on: 

### • QSARs • ToxCast • EDSP Tier 1 data • OSRI Relies on: 

### • EDSP Tier 2 data • OSRI

FIFRA SAP: Integrated Bioactivity Exposure Ranking Dec 2 - 5, 2014 Slide 4 of 7

## http://www.epa.gov/endo/pubs/edsp21_work_plan_summary%20_overview_final.pdf FIFRA SAP: Integrated Bioactivity Exposure Ranking Dec 2 - 5, 2014 Slide 5 of 7

### http://www.epa.gov/endo/pubs/EDSP_Comprehesive_Management%20Plan_%20021414_f.pdf FIFRA SAP: Integrated Bioactivity Exposure Ranking Dec 2 - 5, 2014 Slide 6 of 7

# Current Status of EPA Prioritization & Screening

 52 List 1 chemicals with complete Tier 1 datasets undergoing weight - of- evidence determination of endocrine bioactivity, possible Tier 2 testing  107 List 2 chemicals being prioritized for EDSP screening using high throughput and computational methods  EDSP universe of chemicals being prioritized for EDSP screening using high throughput and computational methods  FIFRA Scientific Advisory Panel peer reviews • Prioritizing the Universe of Endocrine Disruptor Screening Program (EDSP) Chemicals Using Computational Toxicology Tools (January 2013)

– http://www.regulations.gov (Search under EPA docket number: EPA- HQ- OPP - 2012 - 0818 ) 

### • Endocrine Disruptor Screening Program (EDSP) Tier 1 Screening Assays and Battery Performance ( May 2013)

– http://www.regulations.gov (Search under EPA docket number: EPA- HQ- OPP - 2013 - 0075) 

### • Endocrine Disruptor Screening Program (EDSP) Tier 2 Ecotoxicity Tests (June 2013)

– http://www.regulations.gov (Search under EPA docket number: EPA- HQ- OPP - 2013 - 0182) 

### • Weight- of- Evidence : Evaluating Results of EDSP Tier 1 Screening (July 2013)

– http://www.regulations.gov (Search under EPA docket number: EPA- HQ- OPP - 2013 - 0230) 

### • New High Throughput Methods To Estimate Chemical Exposure (July 2014)

– http://www.regulations.gov (Search under EPA docket number: EPA- HQ- OPP - 2014 - 0331) 

### • Endocrine Activity and Exposure - based Prioritization and Screening (December 2014)

– http://www.regulations.gov (Search under EPA docket ID: EPA- HQ- OPP - 2014- 0614)
FIFRA SAP: Integrated Bioactivity Exposure Ranking Dec 2 - 5, 2014 Slide 7 of 7