### Page 1 of 20 

## UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF CHEMICAL SAFETY

AND POLLUTION PREVENTION



## MEMORANDUM

Date: 17

- November

- 20 1 5

Subject: Carfentrazone

- ethyl

. S ection 3 Registration for Application to Globe Artichoke,

Asparagus, Mint, Psyllium, Quinoa, and Teff and Updating the Crop Group (CG) or Subgroup (CSG) Designation for Bulb Vegetables (CG 3

- 07); Fruiting Vegetables (CG 8

- 10); Citrus (CG 10

- 10); Pome Fruit (CG 11

- 10); Stone Fruit (CG 12

- 12); Caneberry (CSG 13

- 07A); Bushberry (CSG 13

- 07B); Fruit, Small Vine Climbing, Except Fuzzy Kiwifruit (CSG 13

- 07F); Berry, Low Growing (CSG 13

- 07G); Tree Nuts (CG 14

- 12); and Oilseed (CG 20). Dietary Exposure Assessment

.

PC Codes: 128712 DP Barcode: D 428859

Decision No.: 4 98511 Registration Nos. : 279

- 3194; 279

- 3241; 279

- 3242

Petition No.: 4E8337 Regulatory Action: Section 3 Risk Assessment Type: dietary Case No.: 7422

T XR No.: not applicable CAS No.: 128639

- 02

- 1

MRID No.: none 40 CFR: 180.515



## From /To : Tom Bloem, Chemist

Risk Assessment Branch 1 /Health Effects Division (RAB1/HED; 7509 P )

Through: Sumitra Biswas, Chemist, RAB6/HED

Doug Dotson, Ph.D., Chemist, RAB2/HED Dietary Exposure Science Advisory Committee (DESAC) Secondary Review

George F. Kramer, Ph.D., Senior Chemist RAB1/HED (7509 P )

Executive Summary

D ietary (food and drinking water) exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model

- Food Consumption Intake Database (DEEM

- FCID, ver. 3.16) which incorporates food consumption data from the United States Department of Agriculture (USDA) National Health and Nutrition Examination Survey, What We Eat in Am erica (NHANES/WWEIA;

2003

- 2008). The analysi s w as conducted in support of the proposed Section 3 registration for application of carfentrazone

- ethyl to globe artichoke, asparagus, mint, p syllium, q uinoa

, and teff and the proposed updates to the crop definitions for several CGs and CSGs.

The chronic analysi s assumed tolerance

- level residues or, if necessary, tolerance

- level residues adjusted to account for the residues of concern for risk assessment, 100 % crop treated, and modeled drinking water estimates (based on toxicological considerations, acute and cancer analyses are unnecessary)

. Since adequate processing studies have been submitted which indicate that tolerances in/on apple juice, citrus juice, grape juice, grape raisin, dried potato, dried prune,

### Carfentrazone

- ethyl (128712) Dietary Exposure Assessment D428859

Page 2 of 20 

## prune juice, tomato paste, and tomato puree are unnecessary, the DEEMTM (ver 7.81) default processing factors for these commodities were reduced to 1. The DEEMTM (ver 7.81) default processing factors wer e retained for the remaining relevant commodities. The resulting chronic exposure estimates are not of concern to HED ( ≤ 78 % c hronic population adjusted dose (c PAD ) ; children 1

- 2 years old were the most highly exposed subgroup ).

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose

that HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the PAD. The PAD is equivalent to the point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors. For non

- cancer chronic exposures, HED

is concerned when estimated die tary risk exceeds 100% of the PAD. References that discuss the chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21

- JUN

- 2000, web link: http://www.regulations.gov/#!documentDetail;D=EPA

- HQ

- OPP

- 2007

- 0780

- 0001 ; or see SOP 99.6 (20

- A ug

- 1999). The most recent dietary risk assessment for carfentrazone

- et hyl was conducted by T. Bloem ( D3 89977

, 29

- Feb

- 20 12 ).

II. Residue Information

Residues of Concern in Plants (primary and rotational)

, Livestock , and Water : Table 1 is a summary of the residues of concern for tolerance enforcement and risk assessment in plants, livestock, fish, and water. For further information concerning these decisions

, see the following

human

- health risk assessment

- D 425574

, T. Bloem et al.

, ??

- ???

- 201 5

.

Table 1 : Summary of Residues to be Included in the Risk Assessment and Tolerance Expression.

Matrix Residues of Concern for

Risk Assessment Residues of Concern for

Tolerance Assessment

plants Primary Crops (cereal grain, cotton, grass, mint, asparagus, teff, quinoa, psyllium) carfentrazone

- ethyl and CR

- 75

carfentrazone

- ethyl and CR

- 75 Primary Crop (nongrass animal feed) carfentrazone

- ethyl, CR

- 75, and CR

- 48 Primary Crops (remaining proposed/ registered crops) carfentrazone

- ethyl, CR

- 75, CR

- 48, 3

- OH

- F8426

- BAc, F8426

- BAc, and Me

- 3

- OH

- F8426

- BAc

Rotational Crops carfentrazone

- ethyl and CR

- 75; the MARC also expressed concern for the residues of the benzoic acid compounds if the levels found are similar to or greater than the parent and the metabolite livestock (ruminant poultry) carfentrazone

- ethyl and CR

- 75

fish/shellfish carfentrazone

- ethyl and CR

- 75

water carfentrazone

- ethyl, CR

- 75, and F8426

- CAc not applicable



## HED R ecommended Tolerances : Table 2 is a summary of the HED

- recommended tolerances

for the combined residues of carfentrazone

- ethyl and carfentrazone

- chloropropionic acid ( CR

75; expressed in parent equivalents) resulting from the current action

. HED notes that proposed changes to the banana and cereal grain tolerances are based on recommendations made as part of scoping assessment submit ted in support of registration review (D382666, K. Lowe et al. , 9

- Feb

2011). With the establishment of the tolerances listed in Table 2, the following tolerances will be deleted: barley, bran; barley, flour; berry group 13; borage; caneberry subgroup 13A; canola; coconut; corn, field, forage; corn, sweet, forage; corn, sweet, kernel plus cob with husk removed; cotton, undelinted seed; cotton, hulls; cotton, meal; cott on, refined oil; crambe, seed; flax, seed;

### Carfentrazone

- ethyl (128712) Dietary Exposure Assessment D428859

Page 3 of 20 

## fruit, citrus, group 10; fruit, pome, group 11; fruit, stone, group 12; grain, cereal, forage, fodder and straw group 16, except corn and sorghum, forage; grain, cereal, forage, fodder and straw, group 16, hay; gr ain, cereal, forage, fodder and straw, group 16, stover; grain, cereal, forage, fodder and straw, group 16, except rice, straw; grain, cereal, group 15; grain, cereal, stover; grain cereal, straw; grape; juneberry; lingonberry; millet, flour; mustard, seed ; nut, tree, group 14; oat, flour; okra; pistachio; pummelo; rapeseed, seed; rice, hulls; rice, straw; rye, bran; rye, flour; safflower, seed; salal; sorghum, forage; sorghum, sweet; strawberry; sunflower, seed; vegetable, bulb, group 3; vegetable, fruitin g, group 8; wheat, bran; wheat, flour; wheat, germ; wheat, middlings; and wheat, shorts.

Table 2: Tolerance Summary

Commodity HED

- Recommended Tolerance (ppm)

artichoke, globe 0.10

asparagus 0.10
peppermint, tops 0.10
spearmint, tops 0.10

teff, grain 0.25
teff, forage 1.0
teff, hay 0.30

teff, straw 3.0
vegetable, bulb, group 3

- 07 0.10
vegetable, fruiting, group 8

- 10 0.10
fruit, citrus, group 10

- 10 0.10
fruit, pome, group 11

- 10 0.10
fruit, stone, group 12

- 12 0.10
caneberry subgroup 13

- 07A 0.10
bushberry subgroup 13

- 07B 0.10
fruit, small vine climbing, subgroup 13

- 07F, except Fuzzy kiwifruit 0.10

berry, low growing, subgroup 13

- 07G 0.10
nut, tree, group 14

- 12 0.10
rapeseed subgroup 20A 0.10
sunflower subgroup 20B 0.10

cottonseed subgroup 20C 0.20
quinoa, grain 0.10
psyllium, seed 0.10

banana 0.10

g rain, cereal, group 16, forage 1.0

g rain, cereal, group 16, hay 0.30

g rain, cereal, group 16, stover 0.80

g rain, cereal, group 16, straw 3.0



## Plant Residues Incorporated into the Chronic Dietary Exposure Assessment: The chronic analys is assumed 100% crop treated

. Since adequate processing studies have been submitted which indicate that tolerances in/on apple juice, citrus juice, grape juice, grape raisin, dried potato, dried prune, prune juice, tomato paste, and tomato puree are unnecessary, the DEEMTM (ver 7.81) default processing factors for these commodities were reduced to 1. The DEEMTM (ver 7.81) default processing factors were retained for the remainin g relevant commodities. The following paragraphs and Table 2 are summaries of the residues incorporate d into the chronic dietary exposure analysis

.

Cereal grain

, Cotton , Mint , Asparagus, Teff, Quinoa, and Psyllium : For c ereal grain, c otton,

### Carfentrazone

- ethyl (128712) Dietary Exposure Assessment D428859

Page 4 of 20 

## m int, a sparagus, t eff, q uinoa, and p syllium , the residues of concern for tolerance enforcement

and risk assessment are identical . T herefore, the chr o nic dietary exposure analysis assumed

tolerance level residues for these crops

. As indicated above, the small grain ( barley, millet, oat, rye, and wheat) processed commodities are being deleted and therefore the raw agricultural commodity (RAC) tolerances were assumed for the processed commodities ( D351363, T. Bloem, 14

- May

- 2008).

Nongrass animal feed: T he only food commodity associated with the nongrass animal feed crop group is alfalfa seed . The alfalfa field trial data result ed in a maximum combined carfentrazone

ethyl, CR

- 75, and CR

- 48 residue of 2.847 ppm in/on alfalfa seed (48397305.der.docx). S ince

this is lower than the recommended 15 ppm tolerance for combined carfentrazone

- ethyl and CR

75 , the assessment assumed tolerance level re sidues

.

Remaining Registered Crops: F or th e remaining crops, the residues of concern for risk

assessment are c arfentrazone

- ethyl, CR

- 75

, CR

- 48 , 3

- OH

- F8426

- BAc, F8426

- BAc, and Me

- 3

- OH

- F8426

- BAc. The petitioner has not monitored for residues of 3

- OH

- F8426

- BAc, F8426

- BAc, and/or Me

- 3

- OH

- F8426

- BAc in the majority of the field trial studies. Therefore, HED

estimated residues for these compounds using the following maximum residue ratios from the confined rotational crop study: (1) 3

- OH

- F8426

- BAc:carfentrazone

- ethyl

- 12.0; (2) F8426

- BAc:carfentrazone

- ethyl

- 3.8; and (3) Me

- 3

- OH

- F8426

- BAc:carfentrazone

- ethyl

- 4.8. HED

concludes that the residue estimates for 3

- OH

- F8426

- BAc, F8426

- BAc, and/or Me

- 3

- OH

F8426

- BAc are conservative for the following reasons: (1) LOD residues for carfentrazone

- ethyl were assumed (residues of carfentrazone

- ethyl were <LOD); (2) maximum resi due ratios from the confined study were assumed; (3) residues of 3

- OH

- F8426

- BAc were monitored in the legume vegetable and sugar cane field trial studies with residues <LOD (LOD  0.03 ppm) in/on

pea / bean /sugarcane and <0 .05 ppm in/on legume vegetable foliag e; these residues are much less

than the residue estimate used in the dietary exposure analysis of 0.36 ppm.

Fish/Shellfish: For fish/shellfish, the residues of concern for tolerance enforcement and risk

assessment are identical . T herefore, the chronic dietary exposure analysi s assumed tolerance

level fish/shellfish residues. HED notes that these tolerances are based on a magnitude of the residue study which employed a single application at 0.30 lb ai/surface acre ( 1.5x the registe red aquatic and rice application rate; D294823, T. Bloem, 15

- Jul

- 2004).

Livestock: Since the livestock maximum reasonable dietary burdens (MRDBs) for risk

assessment are only slightly higher than the MRDBs for tolerance enforcement and since these

diet ary burdens are based on tolerance level residues and 100% crop treated, HED concludes that the livestock tolerances may be used in the chronic dietary exposure analysi s

.

### Carfentrazone

- ethyl (128712) Dietary Exposure and Risk Assessment D428859

Page 5 of 20 Table 3. Summary of Carfentrazone

- ethyl Tolerances and Combined Residues of Concern

Commodity Tolerance (ppm) application scenario residue (ppm)

F8426 1 CR

- 75 1 CR

- 48 1 3

- OH

F8426

- BAc 2 F8426

- BAc Me

- 3

- OH

F8426

- BAc combined

cereal grain, grain ( including processed commodities; except rice and sorghum grain) 0.10

foliar or, soil

- directed

and foliar residues of concern for risk assessment the same as for tolerance expressions; tolerance level residues assumed rice grain (including processed commodities) 1.3

grain sorghum grain (including processed commodities) 0.25

cottonseed oil 0 .20

asparagus 0.10

mint 0.10

teff, grain 0.25

quinoa, grain 0.10

psyllium, grain 0.10

alfalfa seed 15 Residues of concern for risk assessment are carfentrazone

- ethyl, CR

- 75, and CR

- 48; t he

alfalfa field trial data resulted in a maximum combined carfentrazone

- ethyl, CR

- 75, and CR

48 residue of 2.847 ppm in/on alfalfa seed (48397305.der.docx). Since this is lower than the recommended 15 ppm tolerance

, the assessment assumed tolerance level residues.

vegetable, root and tuber, group 01 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

vegetable, leaves of root and tuber, group 02 3 0.10 soil

- directed 0.02 0.04 0.05 0.24 0.08 0.10 0.52

vegetable, bulb, group 03

- 07 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

vegetable, leafy, except brassica, group 04 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

vegetable, brassica leafy, group 05 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

vegetable, legume, group 06 2 0.10 soil

- directed 0.03 0.03 0.03 0.03 0.11 0.14 0.38

vegetable, fruiting, group 08

- 10 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

vegetable, cucurbit, group 09 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

fruit, citrus, group 10

- 10 0.10 soil

- directed 0.01 0.03 0.03 0.12 0.04 0.05 0.28

fruit, pome, group 11

- 10 0.10 soil

- directed 0.01 0.03 0.03 0.12 0.04 0.05 0.28

fruit, stone, group 12

- 12 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

caneberry subgroup 13

- 07A 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

bushberry subgroup 13

- 07B 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

fruit, small vine climbing, subgroup 1 3

- 07F

, except Fuzzy kiwifruit 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

berry, low growing, subgroup 13

- 07G 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

nut, tree, group 14

- 12 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

herbs and spices group 19 4 2.0 soil

- directed 0.44 0.44 0.44 5.28 1.67 2.11 10.38

oilseed g roup 20 (except cotton) 0.1 0 soil

- directed 0.03 0.03 0.03 0.36 0.1 1 0.1 4 0.71

acerola 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

### Carfentrazone

- ethyl (128712) Dietary Exposure and Risk Assessment D428859

Page 6 of 20 Table 3. Summary of Carfentrazone

- ethyl Tolerances and Combined Residues of Concern

Commodity Tolerance (ppm) application scenario residue (ppm)

F8426 1 CR

- 75 1 CR

- 48 1 3

- OH

F8426

- BAc 2 F8426

- BAc Me

- 3

- OH

F8426

- BAc combined

artichoke, globe 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

avocado 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

banana/plantain 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

cacao (cocoa bean) 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

cactus 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

canistel 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

cherimoya 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

coffee 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

date 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

feijoa 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

fig 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

guava 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

hop, dried cones 5 0.10 soil

- directed 0.05 0.05 0.05 0.60 0.19 0.24 1.18

jaboticaba 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

kiwifruit 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

longan 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

lychee 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

mango 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

mulberry 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

olive 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

palm heart 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

palm heart, leaves 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

papaya 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

passionfruit 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

pawpaw 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

peanut, nutmeat 6 0.10 soil

- directed/harvest

- aid 0.03 0.03 0.04 0.36 0.11 0.14 0.72

persimmon 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

pomegranate 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

sapote, mamey 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

sorghum, sweet 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

soursop 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

spanish lime 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

starfruit 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

### Carfentrazone

- ethyl (128712) Dietary Exposure and Risk Assessment D428859

Page 7 of 20 Table 3. Summary of Carfentrazone

- ethyl Tolerances and Combined Residues of Concern

Commodity Tolerance (ppm) application scenario residue (ppm)

F8426 1 CR

- 75 1 CR

- 48 1 3

- OH

F8426

- BAc 2 F8426

- BAc Me

- 3

- OH

F8426

- BAc combined

sugar apple 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

sugarcane 7 0.15 soil

- directed/harvest

- aid 0.03 0.07 0.07 0.03 0.11 0.14 0.45

tea 0.10 soil

- directed 0.03 0.03 0.03 0.36 0.11 0.14 0.71

meat, byproducts (cattle, goat, hog, horse, and sheep) 0.10

not applicable residues of concern for risk assessment the same as for tolerance expressions;

tolerance level residues assumed meat (cattle, goat, hog, horse, and sheep) 0.10

fat (cattle, goat, hog, horse, and sheep) 0.10

meat, byproducts (poultry) 0.10

milk 0.05

fish/shellfish 0.30

1 R esidues of carfentrazone

- ethyl (F8426)

, CR

- 75 , and CR

- 48 were < LOD for all crops where only soil

- directed applications were proposed/registered (except hops and leaves of root and tuber vegetables; see below); LOD = 0.01 ppm for F8426 in citrus and pome fruit

, and ≤ 0.03 ppm for remaining crops /anlaytes

. 2 R esidues of 3

- OH

- F8426

- BAc were monitored in the legume vegetable (pea/bean and foliage) and sugarcane field trial studies; residues were <LOD (LOD  0.03 ppm) in pea/bean/sugarcane and <LOQ (LOQ = 0.05 ppm) in legume vegetable foliage

. 3 R esidues in leaves of root an d tuber were >LOD but <LOQ; maximum residue used for calculation of combined residues

. 4 Re sidues in leafy vegetables (except brassica) translated to the herb and spice crop group with adjustment for percent dry matt er (6.1% for leafy vegetables and 90% fo r herb and spices)

. 5 R esidues in hop were reported as <LOQ; therefore, residues at the LOQ were assumed

. 6 R esidues of carfentrazone

- ethyl

, CR

- 75, and CR

- 48 were <LOD in/on peanut nutmeat following soil directed and/or harvest

- aid application (LOD = 0.01

- 0.03 ppm for carfentrazone

ethyl , 0.02

- 0.03 ppm for CR

- 75 , and 0.03

- 0.04 ppm for CR

- 48 )

7 R esidues of carfentrazone

- ethyl and 3

- OH

- F8426

- BAc were ≤LOD in/on sugarcane following soil directed and/or harvest

- aid application (LOD = 0.02

- 0.03 ppm) ; residues of CR

- 75

and CR

- 48 were ≤0.07 ppm and ≤0.07 ppm, respectively, following soil directed and harvest

- aid application

.

### Carfentrazone

- ethyl (128712) Dietary Exposure and Risk Assessment D428859

Page 8 of 20 

## I II. Drinking Water Data

Comsoderomg all registered/proposed uses, t he rice and caneberry application scenarios yield the highest surface water and ground water estimated drink ing water concentrations (EDWCs;

D 425572 , R. Shamblen

, 16

- Sep

- 2015) ; the EDWCs for these uses are summarized in Table 4

. The surface water EDWCs resulting from the rice use were generated using the Tier I Rice

Model . The groundw ater EDWC f r om the caneber ry use was generated using Pesticide Root

Zone Model for Ground W at er (PRZM

- GW)

. Additional information concerning these m odels

are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/ . The EDWCs from the rice use are the highest and were incorporated into the chronic dietary exposure analys i s ( “water, direct, all sources” and “water, indirect, all sources”).

Table 4 : EWDCs

. Drinking Water Source (Model) Application Rate Value for Chronic Assessment (μg/L)

s urface water (Tier I Rice Model) r ice, wild rice (0.20 lbs ai/ acre ) 86

g round water ( PRZM

- GW ) c aneberries (0.4 lbs ai/ acre ) 43.9



## I V

. DEEM

- FCIDTM Program and Consumption Information

The c arfentrazone

- ethyl chronic dietary exposure assessment w as conducted using the DEEM

FCID (v er

. 3.16 ) which incorporates 2003

- 2008 consumption data from USDA’s NHANES/WWEIA. The data are based on the reported consumption of more than 20,000

individuals over two non

- consecutive survey days. Foods “as consumed” (e.g., apple pie) are

linked to EPA

- defined food commodities (e.g., apples, peeled fruit

- cooked; fresh or N/S; baked;

or wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, co nsumption data are averaged for the entire U.S. population and within population subgroups. Based on analysis

of the 2003

- 2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropria te to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1

- 2, children 3

- 5,

children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and adults 50

- 99 years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or food

form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake es timate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/k g body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup.

### Carfentrazone

- ethyl (128712) Dietary Exposure and Risk Assessment D428859

Page 9 of 20 

## V. Toxicological Information

Table 5 is a summar y of the toxicological doses and endpoints for carfentrazone

- ethyl dietary

exposure assessment

. B ased on the toxicological database and residue assumptions, RAB1 concluded that the Food Quality Protection Act (FQPA) safety factor (SF) may be reduced to 1x. For a complete discussion concerning these conclusions, see the human

- health risk assessment

D ??? ( T. Bloem et al.

, ??

- Nov

- 201 5 ).

Table 5 : Summary of Toxicological Doses and Endpoints for Carfentrzone

- Ethyl for Use in Dietary, Non

Occupational, and Occupational Human Health Risk Assessments

Exposure/

Scenario Point of Departure Uncertainty/ FQPA Safety Factors RfD, PAD, Level of

Concern for Risk

Assessment Study and Toxicological Effects

Acute Dietary (all populations) No appropriate toxicological effects attributable to a single dose were observed. Therefore, a dose and endpoint were

not identified for this risk assessment.

Chronic Dietary (All Populations) NOEL=

3.0 mg/kg/day UFA= 10x

UFH=10x FQPA SF= 1x cRfD = 0.03 mg/kg/day

aPAD = 0.03mg/kg/day Chronic toxicity

- rats:
LOEL = 12 mg/kg/day based on liver histopathology (increases in microscopic red fluorescence and pigmentation) and increased urinary porphyrin levels in both sexes Cancer (oral, dermal, inhalation) Classification: “Not likely to be carcinogen,” cancer risk assessme nt is not required

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose

- response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (interspecies). UF H = potential variation in sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD =

reference dose.



## V I

. Results/Discussion & Conclusions

The unrefi ned chronic analysi s resulted in risk estimate s that are not of concern to HED (see

Table 6 ; ≤ 78 % cPAD; children 1

- 2 years old were the most highly exposed subgroup )

.

Table 6 : Summary of the Chronic Dietary Exposure s and Risk s

.

Population cPAD (mg/kg/day) Exposure (mg/kg/day) %cPAD

General U.S. Population

0.03 0.007 972 2 7
All Infants (< 1 year old) 0.01 7437 5 8

Children 1

- 2 years old 0.023432 7 8

Children 3

- 5 years old 0.017502 5 8

Children 6

- 12 years old 0.010253 3 4

Youth 13

- 19 years old 0.00 6020 20

Adults 20

- 49 years old 0.006616 2 2

Adults 50

- 99 years old 0.006598 2 2

Females 13

- 49 years old 0.006453 2 2

### Carfentrazone

- ethyl (128712) Dietary Exposure and Risk Assessment D428859

Page 10 of 20 

## V II

. Characterization of Inputs/Outputs

The chronic analysis is conservative and could be refined through the incorporation of maximum

or average field trial residues, residue monitoring data, percent crop treated estimates, and/or empirical processing factors.

VII I

. C onclusions

The chronic analysi s assumed tolerance

- level residues or, if necessary, tolerance

- level residues adjusted to account for the residues of concern for risk assessment, 100% crop treated, and modeled drinking water estimates. Since adequate processing studies have been submitt ed which indicate that tolerances in/on apple juice, citrus juice, grape juice, grape raisin, dried potato, dried prune, prune juice, tomato paste, and tomato puree are unnecessary, the DEEMTM (ver 7.81) default processing factors for these commodities were reduced to 1. The DEEMTM (ver 7.81) default processing factors were retained for the remaining relevant commodities. The resulting chronic exposure estimates are not of concern to HED ( ≤ 78 % cPAD; children 1

- 2 years old were the most highly exposed subgro up ).

Attachment 1 : DEEM

- FCIDTM chronic exposure estimates

Attachment 2 : DEEM

- FCIDTM chronic residue file

### Carfentrazone

- ethyl (128712) Dietary Exposure and Risk Assessment D428859

Page 11 of 20 

### Attachment 1: DEEM

- FCIDTM chronic exposure estimates

US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for CARFENTRAZONE

- ETHYL NHANES 2003

- 2008 2

- day

Residue file name: C: \ Users \ tbloem \ Documents \ work \ carfentrazone

- ethyl \ artichoke, asparagus, mint, teff, and new crop group tolerances \ 128712C.R08 Adjustment factor #2 NOT used. Analysis Date 09

- 18

- 2015/12:21:49 Residue file dated: 09

- 18

- 2015/12:21:27 Reference dose (RfD, Chronic) = .03 mg/kg bw/day

COMMENT 1: FQPA SF = 1x

============================================================== ================= Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.007972 26.6% Hispanic 0.008829 29.4%

Non

- Hisp

- White 0.007822 26.1%

Non

- Hisp

- Blac k 0.007118 23.7%

Non

- Hisp

- Other 0.009788 32.6% Nursing Infants 0.009367 31.2%

Non

- Nursing Infants 0.021041 70.1%

Female 13+ PREG 0.007304 24.3%

Children 1

- 6 0.019087 63.6%

Children 7

- 12 0.009528 31.8%

Male 13

- 19 0.006136 20.5%

Female 13

- 19/NP 0.005915 19.7%

Male 20+ 0.006549 21.8%
Female 20+/NP 0.006636 22.1%

Seniors 55+ 0.006560 21.9%

All Infants 0.017437 58.1%

Female 13

- 50 0.006456 21.5 %

Children 1

- 2 0.023432 78.1%

Children 3

- 5 0.017502 58.3%

Children 6

- 12 0.010253 34.2%

Youth 13

- 19 0.006020 20.1%

Adults 20

- 49 0.006616 22.1%

Adults 50

- 99 0.006598 22.0%

Female 13

- 49 0.006453 21.5%

-------------------------------------------------------------------------------

### Carfentrazone

- ethyl (128712) Dietary Exposure and Risk Assessment D428859

Page 12 of 20 

## Attachment 2 : DEEM

- FCIDTM chronic residue file

Filename: C: \ Users \ tbloem \ Documents \ work \ carfentrazone

- ethyl \ artichoke, asparagus, mint, teff, and new crop group tolerances \ 128712C.R08

Chemical: carfentrazone

- ethyl RfD(Chronic): .03 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day
Date created/last modified: 09

- 18

- 2015/12:21:27 Program ver. 3.16, 03

- 08

- d
Comment: FQPA SF = 1x

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 9500001000 O Acerola 0.710000 1.000 1.000 9500016000 O Artichoke, globe 0.710000 1.000 1.000

950001900 0 O Asparagus 0.710000 1.000 1.000

9500020000 O Avocado 0.710000 1.000 1.000

9500023000 O Banana 0.710000 1.000 1.000
9500024000 O Banana, dried 0.710000 3.900 1.000
9500024001 O Banana, dried

- babyfood 0.710000 3.900 1.000

9500023001 O Banana

- babyfood 0.710000 1.000 1.000

9500073000 O Cactus 0.710000 1.000 1.000

9500074000 O Canistel 0.710000 1.000 1.000 9500089000 O Cherimoya 0.710000 1.000 1.000
9500109000 O Cocoa bean, chocolate 0.710000 1.000 1.000

9500110 000 O Cocoa bean, powder 0.710000 1.000 1.000
9500112000 O Coconut, dried 0.710000 2.100 1.000
9500111000 O Coconut, meat 0.710000 1.000 1.000
9500111001 O Coconut, meat

- ba byfood 0.710000 1.000 1.000
9500113000 O Coconut, milk 0.710000 1.000 1.000
9500114000 O Coconut, oil 0.710000 1.000 1.000
9500116000 O Coffee, instant 0.7100 00 1.000 1.000
9500115000 O Coffee, roasted bean 0.710000 1.000 1.000

9500141000 O Date 0.710000 1.000 1.000 9500151000 O Feijoa 0.710000 1.000 1.000 9500153000 O Fig 0.710000 1.000 1.000 9500154000 O Fig, dried 0.710000 1.000 1.000 9500177000 O Grape, leaves 0.710000 1.000 1.000 9500178000 O Grape, ra isin 0.710000 1.000 1.000

9500183000 O Guava 0.710000 1.000 1.000

9500183001 O Guava

- babyfood 0.710000 1.000 1.000 9500188000 O Hop 1.180000 1.000 1.000 9500209000 O Longan 0.710000 1.000 1.000 9500211000 O Lychee 0.710000 1.000 1.000 9500212000 O Lychee, dried 0.710000 1.850 1.000 9500215000 O Mango 0.710000 1.000 1.000 9500216000 O Mango, dried 0.710000 1.000 1.000 9500217000 O Mango, juice 0.710000 1.000 1.000 9500217001 O Mango, juice

- babyfood 0.710000 1.000 1.000 9500215001 O Mango

- babyfood 0.710000 1.000 1.000

9500235000 O Olive 0.710000 1.000 1.000
9500236000 O Olive, oil 0.710000 1.000 1.000
9500243000 O Palm heart, leaves 0.710000 1.000 1.000
9500244000 O Palm, oil 0.710000 1.000 1.000
9500244001 O Palm, oil

- babyfood 0.710000 1.000 1.00 0 9500245000 O Papaya 0.710000 1.000 1.000 9500246000 O Papaya, dried 0.710000 1.800 1.000 9500247000 O Papaya, juice 0.710000 1.500 1.000 9500245001 O Papay a

- babyfood 0.710000 1.000 1.000

9500252000 O Passionfruit 0.710000 1.000 1.000 9500253000 O Passionfruit, juice 0.710000 1.000 1.000 9500253001 O Passionfruit, juice

- babyfood 0.710000 1.000 1.000

### Carfentrazone

- ethyl (128712) Dietary Exposure and Risk Assessment D428859

Page 13 of 20 9500252001 O Passionfruit

- babyfood 0.710000 1.000 1.000 9500254000 O Pawpaw 0.710000 1.000 1.000

9500263000 O Peanut 0.720000 1.000 1.000
9500264000 O Peanut, butter 0.720000 1.890 1.000
9500265000 O Peanut, oil 0.720000 1.000 1.000 9500275000 O Peppermin t 0.100000 1.000 1.000 9500276000 O Peppermint, oil 0.100000 1.000 1.000

9500277000 O Persimmon 0.710000 1.000 1.000

9500283000 O Plantain 0.710000 1.000 1.000
9500284000 O Plantain, dried 0.710000 3.900 1.000 9500289000 O Pomegranate 0.710000 1.000 1.000 9500306000 O Psyllium, seed 0.100000 1.000 1.000 9500311000 O Quinoa, grain 0.100000 1.000 1.000 9500333000 O Sapote, Mamey 0.710000 1.000 1.000 9500346000 O Soursop 0.710000 1.000 1.000 9500351000 O Spanish lime 0.710000 1.000 1.000 9500352000 O Spearmint 0.100000 1.000 1.000 9500353000 O Spearmint, oil 0.100000 1.000 1.000

9500358000 O Starfruit 0.710000 1.000 1.000 9500361000 O Sugar apple 0.710000 1.000 1.000 9500363000 O Sugarcane, molasses 0.450000 1.000 1.000 9500363001 O Sugarcane, molasses

- babyfood 0.450000 1.000 1.00 0 9500362000 O Sugarcane, sugar 0.450000 1.000 1.000 9500362001 O Sugarcane, sugar

- babyfood 0.450000 1.000 1.000
9500372000 O Tea, dried 0.710000 1.000 1.000
9500373000 O Tea, instant 0.710000 1.000 1.000
9500373500 O Teff, flour 0.250000 1.000 1.000
0103015000 1CD Arrowroot, flour 0.710000 1.000 1.000
0103015001 1CD Arrowroot, flour

- babyfood 0.710000 1.000 1.000
0103017000 1CD Artichoke, Jerusalem 0.710000 1.000 1.000 0101050000 1AB Beet, garden, roots 0.710000 1.000 1.000 0101050001 1AB Beet, garden, roots

- babyfood 0.710000 1.000 1.000 0101052000 1A Beet, sugar 0.710000 1.000 1.000 0101053000 1A Beet, sugar, molasses 0.710000 1.000 1.000 0101053001 1A Beet, sug ar, molasses

- babyfood 0.710000 1.000 1.000 0101052001 1A Beet, sugar

- babyfood 0.710000 1.000 1.000

0101067000 1AB Burdock 0.710000 1.000 1.000

0101078000 1AB Carrot 0.710000 1.000 1.000 0101079000 1AB Carrot, juice 0.710000 1.000 1.000

0101078001 1AB Carrot

- babyfood 0.710000 1.000 1.000

0103082000 1CD Cassava 0.710000 1.000 1.000

0103082001 1CD Cassava

- babyfood 0.710000 1.000 1.000

0101084000 1AB Celeriac 0.710000 1.000 1.000 0101100000 1AB Chicory, roots 0.710000 1.000 1.000

0103139000 1CD Dasheen , corm 0.710000 1.000 1.000 0103166000 1CD Ginger 0.710000 1.000 1.000 0103167000 1CD Ginger, dried 0.710000 1.000 1.000 0103166001 1CD Ginger

- babyfood 0.710000 1.000 1.000 0101168000 1AB Ginseng, dried 0.710000 1.000 1.000

0101190000 1AB Horseradish 0.710000 1.000 1.000 0101250000 1AB Parsley, turnip rooted 0.710000 1.000 1.00 0 0101251000 1AB Parsnip 0.710000 1.000 1.000 0101251001 1AB Parsnip

- babyfood 0.710000 1.000 1.000 0103296000 1C Potato, chips 0.710000 1.000 1.000

0103297000 1C Potat o, dry (granules/ flakes) 0.710000 1.000 1.000 0103297001 1C Potato, dry (granules/ flakes)

- b 0.710000 1.000 1.000
0103298000 1C Potato, flour 0.710000 1.000 1.000
0103298001 1C Potato, flour

- babyfood 0.710000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.710000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.710000 1.000 1.000 0103299000 1C Potato, tuber, w/peel 0.710000 1.000 1.000 0103299001 1C Potato, tuber, w/peel

- babyfood 0.710000 1.000 1.000

### Carfentrazone

- ethyl (128712) Dietary Exposure and Risk Assessment D428859

Page 14 of 20 0101316000 1AB Radish, Oriental, roots 0.710000 1.000 1.000
0101314000 1AB Radish, r oots 0.710000 1.000 1.000 0101327000 1AB Rutabaga 0.710000 1.000 1.000 0101331000 1AB Salsify, roots 0.710000 1.000 1.000 0103366000 1CD Sweet potato 0.710000 1.000 1.000 0103366001 1CD Sweet potato

- babyfood 0.710000 1.000 1.000
0103371000 1CD Tanier, corm 0.710000 1.000 1.000

0103387000 1CD Turmeric 0.710000 1.000 1.000 0101388000 1AB Turnip, roots 0.710000 1.000 1.000

0103407000 1CD Yam bean 0.710000 1.000 1.000
0103406000 1CD Yam, true 0.710000 1.000 1.000 0200051000 2 Beet, g arden, tops 0.520000 1.000 1.000 0200101000 2 Chicory, tops 0.520000 1.000 1.000
0200140000 2 Dasheen, leaves 0.520000 1.000 1.000 0200317000 2 Radish, Oriental, tops 0.520000 1.000 1.000 0200315000 2 Radish, tops 0.520000 1.000 1.000 0200332000 2 Salsify, tops 0.520000 1.000 1.000
0302103000 3B Chive, fresh leaves 10.380000 1.000 1.00 0
0301165000 3A Garlic, bulb 0.710000 1.000 1.000
0301165001 3A Garlic, bulb

- babyfood 0.710000 1.000 1.000

0302198000 3B Leek 0.710000 1.000 1.000

0301237000 3A Onion , bulb 0.710000 1.000 1.000
0301238000 3A Onion, bulb, dried 0.710000 9.000 1.000
0301238001 3A Onion, bulb, dried

- babyfood 0.710000 9.000 1.000
0301237001 3A Onion, bulb

- babyfood 0.710000 1.000 1.000 0302239000 3B Onion, green 0.710000 1.000 1.000
0301338000 3A Shallot, bulb 0.710000 1.000 1.000
0302338500 3B Shallot, fresh leaves 0.710000 1.000 1.000 0401005000 4A Amaranth, leafy 0.710000 1.000 1.000 0401018000 4A Arugula 0.710000 1.000 1.000

0402076000 4B Cardoon 0.710000 1.000 1.000 0402085000 4B Celery 0.710000 1.000 1.000 0402086000 4B Celery, juice 0.710000 1.000 1.000 0402085001 4B Celery

- babyfood 0.710000 1.000 1.000

0402087000 4B Celtuce 0.710000 1.000 1.000 0401104000 4A Chrysanthemum, garland 0.710000 1.000 1.000 0401133000 4A Cress, garden 0.710000 1.000 1.000 0401134000 4A Cress, upland 0.710000 1.000 1.000
0401138000 4A Dandelion, leaves 0.710000 1.000 1.000

0401150000 4A Endive 0.710000 1.000 1.000
0402152000 4B Fennel, Florence 0.710000 1.000 1.000
0401204000 4A Lettuce, head 0.710000 1.000 1.000
0401205000 4A Lettuce, leaf 0.710000 1.000 1.000 0401248000 4A Parsley, leaves 0.710000 1.000 1.000

0401313000 4A Radicchio 0.710000 1.000 1.000

0402322000 4B Rhubarb 0.710000 1.000 1.000 0401355000 4A Spinach 0.710000 1.000 1.00 0 0401355001 4A Spinach

- babyfood 0.710000 1.000 1.000

0402367000 4B Swiss chard 0.710000 1.000 1.000

0501061000 5A Broccoli 0.710000 1.000 1.000

0502063000 5B Brocc oli raab 0.710000 1.000 1.000
0501062000 5A Broccoli, Chinese 0.710000 1.000 1.000

0501061001 5A Broccoli

- babyfood 0.710000 1.000 1.000 0501064000 5A Brussels sprouts 0.710000 1.000 1.000 0501069000 5A Cabbage 0.710000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok choy 0.710000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 0.710000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 0.710000 1.000 1.000

0501083000 5A Cauliflower 0.710000 1.000 1.000

0502117000 5B Collards 0.710000 1.000 1.000

0502194000 5B Kale 0.710000 1.000 1.000

0501196000 5A Kohlrabi 0.710000 1.000 1.000

### Carfentrazone

- ethyl (128712) Dietary Exposure and Risk Assessment D428859

Page 15 of 20 0502229000 5B Mustard greens 0.710000 1.000 1.000 0502318000 5B Rape greens 0.710000 1.000 1.000 0502389000 5B Turnip, greens 0.710000 1.000 1.000 0603035000 6C Bean, great northern, seed 0.380000 1.000 1.000
0603030000 6C Bean, black, seed 0.380000 1.000 1.000
0603032000 6C Bean, broad, seed 0.380000 1.000 1.000
0602031000 6B Bean, broad, succulent 0.380000 1.000 1.000
0603034000 6C Bean, c owpea, seed 0.380000 1.000 1.000 0602033000 6B Bean, cowpea, succulent 0.380000 1.000 1.000 0603036000 6C Bean, kidney, seed 0.380000 1.000 1.000
0603038000 6C Bean, lima, seed 0.380000 1.000 1.000
0602037000 6B Bean, lima, succulent 0.380000 1.000 1.000 0603039000 6C Bean, mung, seed 0.380000 1.000 1.000 0603040000 6C Bean, navy, seed 0.380000 1.000 1.00 0 0603041000 6C Bean, pink, seed 0.380000 1.000 1.000 0603042000 6C Bean, pinto, seed 0.380000 1.000 1.000 0601043000 6A Bean, snap, succulent 0.380000 1.000 1.000
0601043001 6A Bean, snap, succulent

- babyfood 0.380000 1.000 1.000 0603099000 6C Chickpea, flour 0.380000 1.000 1.000 0603098000 6C Chickpea, seed 0.380000 1.000 1.000 0603098001 6C Chickpea, seed

- babyfood 0.380000 1.000 1.000
0603182000 6C Guar, seed 0.380000 1.000 1.000
0603182001 6C Guar, seed

- babyfood 0.380000 1.000 1.000
0603203000 6C Lentil, seed 0.380000 1.000 1.000 0603256000 6C Pea, dry 0.380000 1.000 1.000 0603256001 6C Pea, dry

- babyfood 0.380000 1.000 1.000
0601257000 6A Pea, edib le podded, succulent 0.380000 1.000 1.000 0603258000 6C Pea, pigeon, seed 0.380000 1.000 1.000 0602259000 6B Pea, pigeon, succulent 0.380000 1.000 1.000
0602255000 6B Pea, succulent 0.380000 1.000 1.000
0602255001 6B Pea, succulent

- babyfood 0.380000 1.000 1.000 0603348000 6C Soybean, flour 0.380000 1.000 1.000 0603348001 6C Soybean, flour

- babyfood 0.380000 1.000 1.000 0600350000 6 Soybean, oil 0.380000 1.000 1.000 0600350001 6 Soybean, oil

- babyfood 0.380000 1.000 1.000 0600347000 6 Soybean, seed 0.380000 1.000 1.000 0600349000 6 Soybean , soy milk 0.380000 1.000 1.000 0600349001 6 Soybean, soy milk

- babyfood or in 0.380000 1.000 1.000 0802148000 8BC Eggplant 0.710000 1.000 1.000

0802234000 8BC Okra 0.710000 1.000 1.000 0802270000 8B Pepper, bell 0.710000 1.000 1.000 0802271000 8B Pepper, bell, dried 0.710000 1.000 1.000 0802271001 8B Pepper, bell, dried

- babyfood 0.710000 1.000 1.00 0 0802270001 8B Pepper, bell

- babyfood 0.710000 1.000 1.000 0802272000 8BC Pepper, nonbell 0.710000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 0.710000 1.000 1.000 0802272001 8BC Peppe r, nonbell

- babyfood 0.710000 1.000 1.000

0801374000 8A Tomatillo 0.710000 1.000 1.000

0801375000 8A Tomato 0.710000 1.000 1.000
0801380000 8A Tomato, Tree 0.710000 1.000 1.000
0801378000 8A Tomato, dried 0.710000 14.300 1.000
0801378001 8A Tomato, dried

- babyfood 0.710000 14.300 1.000 0801379000 8A Tomato, juice 0.710000 1.500 1.000 0801376000 8A Tomato, paste 0.710000 1.000 1.000 0801376001 8A Tomato, paste

- babyfood 0.710000 1.000 1.000 0801377000 8A Tomato, p uree 0.710000 1.000 1.000 0801377001 8A Tomato, puree

- babyfood 0.710000 1.000 1.000

0801375001 8A Tomato

- babyfood 0.710000 1.000 1.000 0902021000 9B Balsam pear 0.710000 1.000 1.000 0901075000 9A Cantaloupe 0.710000 1.000 1.000 0902088000 9B Chayote, fruit 0.710000 1.000 1.000 0902102000 9B Chinese waxgourd 0.710000 1.000 1.000

### Carfentrazone

- ethyl (128712) Dietary Exposure and Risk Assessment D428859

Page 16 of 20 0902135000 9B Cucumber 0.710000 1.000 1.000 0901187000 9A Honeydew melon 0.710000 1.000 1.000 0902308000 9B Pumpkin 0.710000 1.000 1.000 0902309000 9B Pumpkin , seed 0.710000 1.000 1.000 0902356000 9B Squash, summer 0.710000 1.000 1.000 0902356001 9B Squash, summer

- babyfood 0.710000 1.000 1.000 0902357000 9B Squash, winter 0.710000 1.000 1.000 0902357001 9B Squash, winter

- babyfood 0.710000 1.000 1.000

0901399000 9A Watermelon 0.710000 1.000 1.000 0901400000 9A Watermelon, juice 0.710000 1.000 1.00 0

1001106000 10A Citron 0.280000 1.000 1.000 1001107000 10A Citrus hybrids 0.280000 1.000 1.000
1001108000 10A Citrus, oil 0.280000 1.000 1.000 1003180000 10C Grape fruit 0.280000 1.000 1.000 1003181000 10C Grapefruit, juice 0.280000 1.000 1.000 1002197000 10B Kumquat 0.280000 1.000 1.000

1002199000 10B Lemon 0.280000 1.000 1.000 1002200000 10B Lemon, juice 0.280000 1.000 1.000 1002200001 10B Lemon, juice

- babyfood 0.280000 1.000 1.000 1002201000 10B Lemon, peel 0.280000 1.000 1.000

1002206000 10B Lime 0.280000 1.000 1.000 1002207000 10B Lime, juice 0.280000 1.000 1.000 1002207001 10B Lime, jui ce

- babyfood 0.280000 1.000 1.000 1001240000 10A Orange 0.280000 1.000 1.000 1001241000 10A Orange, juice 0.280000 1.000 1.000 1001241001 10A Orange, juice

- babyfood 0.280000 1.000 1.000 1001242000 10A Orange, peel 0.280000 1.000 1.000

1003307000 10C Pummelo 0.280000 1.000 1.000 1001369000 10A Tangerine 0.280000 1.000 1.000 1001370000 10A Tangerine, juice 0.280000 1.000 1.000 1100009000 11 Apple, dried 0.280000 8.000 1.000 1100009001 11 Apple, dried

- babyfood 0.280000 8.000 1.000 1100007000 11 Apple, fruit with peel 0.280000 1.000 1.000 1100010000 11 Apple, juice 0.280000 1.000 1.000 1100010001 11 Apple, juice

- babyfood 0.280000 1.000 1.000 1100008000 11 Apple, peeled fruit 0.280000 1.000 1.000 1100008001 11 Apple, peeled fruit

- babyfood 0.280000 1.000 1.000 1100011000 11 Apple, sauce 0.280000 1.000 1.000 1100011001 11 Apple, sauce

- babyfood 0.280000 1.000 1.00 0 1100129000 11 Crabapple 0.280000 1.000 1.000 1100173500 11 Goji berry 0.710000 1.000 1.000 1100210000 11 Loquat 0.280000 1.000 1.000

1100266000 11 Pear 0.280000 1.000 1.000
1100267000 11 Pear, dried 0.280000 6.250 1.000 1100268000 11 Pear, juice 0.280000 1.000 1.000 1100268001 11 Pear, juice

- babyfood 0.280000 1.000 1.000

1100266001 11 Pear

- babyfood 0.280000 1.000 1.000
1100310000 11 Quince 0.280000 1.000 1.000 1202012000 12B Apricot 0.710000 1.000 1.000 1202013000 12B Apricot, dried 0.710000 6.000 1.000 1202014000 12B Apricot, juice 0.710000 1.000 1.000 1202014001 12B Apricot, juice

- babyfood 0.710000 1.000 1.000 1202012001 12B Apricot

- babyfood 0.710000 1.000 1.000 1201090000 12A Cherry 0.710000 1.000 1.000 1201091000 12A Cherry, juice 0.710000 1.500 1.000 1201091001 12A Cherry, juice

- babyfood 0.710000 1.500 1.000 1201090001 12A Cherry

- babyfood 0.710000 1.000 1.000

1202230000 12B Nectarine 0.710000 1.000 1.000

1202260000 12B Peach 0.710000 1.000 1.000
1202261000 12B Peach, dried 0.710000 7.000 1.000
1202261001 12B Peach, dried

- babyfood 0.710000 7.000 1.000
1202262000 12B Peach, juice 0.710000 1.000 1.000

### Carfentrazone

- ethyl (128712) Dietary Exposure and Risk Assessment D428859

Page 17 of 20 1202262001 12B Peach, juice

- babyfood 0.710000 1.000 1.000

1202260001 12B Peach

- babyfood 0.710000 1.000 1.000

1203285000 12C Plum 0.710000 1.000 1.000 1203287000 12C Plum, prune, dried 0.710000 1.000 1.000 1203287001 12C Plum, prune, dried

- babyfood 0.710000 1.000 1.000 1203286000 12C Plum, prune, fresh 0.710000 1.000 1.00 0 1203286001 12C Plum, prune, fresh

- babyfood 0.710000 1.000 1.000 1203288000 12C Plum, prune, juice 0.710000 1.000 1.000 1203288001 12C Plum, prune, juice

- babyfood 0.710000 1.000 1.000

1203285001 12C Plum

- babyfood 0.710000 1.000 1.000 1301055000 13A Blackberry 0.710000 1.000 1.000 1301056000 13A Blackberry, juice 0.710000 1.000 1.000 1301056001 13A Blackberry, juice

- babyfood 0.710000 1.000 1.000 1302057000 13B Blueberry 0.710000 1.000 1.000 1302057001 13B Blueberry

- babyfood 0.710000 1.000 1.000 1301058000 13A Boysenberry 0.710000 1.000 1.000 1307130000 13G Cranberry 0.710000 1.000 1.000 1307131000 13G Cranberry, dried 0.710000 1.000 1.000 1307132000 13G Cranberry , juice 0.710000 1.100 1.000 1307132001 13G Cranberry, juice

- babyfood 0.710000 1.100 1.000 1307130001 13G Cranberry

- babyfood 0.710000 1.000 1.000

1302136000 13B Currant 0.710000 1.000 1.000
1302137000 13B Currant, dried 0.710000 1.000 1.000 1302149000 13B Elderberry 0.710000 1.000 1.000 1302174000 13B Gooseberry 0.710000 1.000 1.000 1304175000 13D Grape 0.710000 1.000 1.000 1304176000 13D Grape, juice 0.710000 1.000 1.000 1304176001 13D Grape, juice

- babyfood 0.710000 1.000 1.000 1304179000 13D Grape, wine and sherry 0.710000 1.000 1.000 1302191000 13B Huckleberry 0.710000 1.000 1.000 1304195000 13D Kiwifruit, fuzzy 0.710000 1.000 1.000 1301208000 13A Loganberry 0.710000 1.000 1.000 1303227000 13C Mulberry 0.710000 1.000 1.000 1301320000 13A Raspberry 0.710000 1.000 1.000 1301321000 13A Raspberry, juice 0.710000 1.000 1.00 0 1301321001 13A Raspberry, juice

- babyfood 0.710000 1.000 1.000 1301320001 13A Raspberry

- babyfood 0.710000 1.000 1.000 1307359000 13G Strawberry 0.710000 1.000 1.000

1307360000 13G Straw berry, juice 0.710000 1.000 1.000 1307360001 13G Strawberry, juice

- babyfood 0.710000 1.000 1.000 1307359001 13G Strawberry

- babyfood 0.710000 1.000 1.000

1400003000 14 Almond 0.710000 1.000 1.000
1400004000 14 Almond, oil 0.710000 1.000 1.000
1400004001 14 Almond, oil

- babyfood 0.710000 1.000 1.000

1400003001 14 Almond

- babyfood 0.710000 1.000 1.000

1400059000 14 Brazil nut 0.710000 1.000 1.000

1400068000 14 Butternut 0.710000 1.000 1.000

1400081000 14 Cashew 0.710000 1.000 1.000

1400092000 14 Chestnut 0.710000 1.000 1.000

1400155000 14 Hazelnut 0.710000 1.000 1.000
1400156000 14 Hazelnut, oil 0.710000 1.000 1.000 1400185000 14 Hickory nut 0.710000 1.000 1.000

1400213000 14 Macadamia nut 0.710000 1.000 1.000

1400269000 14 Pecan 0.710000 1.000 1.000

1400278000 14 Pine nut 0.710000 1.000 1.000

1400282000 14 Pistachio 0.710000 1.000 1.000

1400391000 14 Walnut 0.710000 1.000 1.000 1500027000 15 Barley, bran 0.100000 1.000 1.000 1500026000 15 Barley, flour 0.100000 1.000 1.000 1500026001 15 Barley, flour

- babyfood 0.100000 1.000 1.000 1500025000 15 Barley, pearled barley 0.100000 1.000 1.000 1500025001 15 Barley, pearled barley

- babyfood 0.100000 1.000 1.000

### Carfentrazone

- ethyl (128712) Dietary Exposure and Risk Assessment D428859

Page 18 of 20 1500065000 15 Buckwheat 0.100000 1.000 1.000
1500066000 15 Buckwheat, flour 0.100000 1.000 1.00 0
1500122000 15 Corn, field, bran 0.100000 1.000 1.000
1500120000 15 Corn, field, flour 0.100000 1.000 1.000
1500120001 15 Corn, field, flour

- babyfood 0.100000 1.000 1.000
1500121000 15 Corn, field, meal 0.100000 1.000 1.000
1500121001 15 Corn, field, meal

- babyfood 0.100000 1.000 1.000
1500125000 15 Corn, field, oil 0.100000 1.000 1.000
1500125001 15 Corn, field, oil

- babyfood 0.100000 1.000 1.000
1500123000 15 Corn, field, starch 0.100000 1.000 1.000
1500123001 15 Corn, field, starch

- babyfood 0.100000 1.000 1.000 1500124000 15 Corn, field, syrup 0.100000 1.500 1.000 1500124001 15 Corn, field, syrup

- babyfood 0.100000 1.500 1.000 1500126000 15 Corn, pop 0.100000 1.000 1.000
1500127000 15 Corn, swe et 0.100000 1.000 1.000
1500127001 15 Corn, sweet

- babyfood 0.100000 1.000 1.000 1500226000 15 Millet, grain 0.100000 1.000 1.000
1500231000 15 Oat, bran 0.100000 1.000 1.000
1500232000 15 Oat, flour 0.100000 1.000 1.000
1500232001 15 Oat, flour

- babyfood 0.100000 1.000 1.000 1500233000 15 Oat, groats/rolled oats 0.100000 1.000 1.000 1500233001 15 Oat, groats/rolled oats

- babyfood 0.100000 1.000 1.000
1500326000 15 Rice, bran 1.300000 1.000 1.000
1500326001 15 Rice, bran

- babyfood 1.300000 1.000 1.000
1500324000 15 Rice, b rown 1.300000 1.000 1.000
1500324001 15 Rice, brown

- babyfood 1.300000 1.000 1.000
1500325000 15 Rice, flour 1.300000 1.000 1.000
1500325001 15 Rice, flour

- babyfood 1.300000 1.000 1.000
1500323000 15 Rice, white 1.300000 1.000 1.000
1500323001 15 Rice, white

- babyfood 1.300000 1.000 1.000 1500329000 15 Rye, flour 0.100000 1.000 1.00 0 1500328000 15 Rye, grain 0.100000 1.000 1.000 1500344000 15 Sorghum, grain 0.250000 1.000 1.000 1500345000 15 Sorghum, syrup 0.710000 1.000 1.000

1500381000 15 Triti cale, flour 0.100000 1.000 1.000
1500381001 15 Triticale, flour

- babyfood 0.100000 1.000 1.000
1500404000 15 Wheat, bran 0.100000 1.000 1.000
1500402000 15 Wheat, flour 0.100000 1.000 1.000
1500402001 15 Wheat, flour

- babyfood 0.100000 1.000 1.000 1500403000 15 Wheat, germ 0.100000 1.000 1.000 1500401000 15 Wheat, grain 0.100000 1.000 1.000 1500401001 15 Wheat, grain

- babyfood 0.100000 1.000 1.000

1500405000 15 Wild rice 0.100000 1.000 1.000
1800002000 18 Alfalfa, seed 15.000000 1.000 1.000
1901029000 19A Basil, dried leaves 10.380000 1.000 1.000
1901029001 19A Basil, dried leaves

- babyfood 10.380000 1.000 1.000
1901028000 19A Basil, fresh leaves 10.380000 1.000 1.000
1901028001 19A Basil, fresh leaves

- babyfood 10.380000 1.000 1.000
1901102500 19A Chive, dried leaves 10.380000 1.000 1.000
1901118000 19A Cilantro, leaves 10.380000 1.000 1.000
1901118001 19A Cilantro, leaves

- babyfood 10.380000 1.000 1.000

1902105000 19B Cinnamon 10.380000 1.000 1.000

1902105001 19B Cinnamon

- babyfood 10.380000 1.000 1.000

1902119000 19B Coriand er, seed 10.380000 1.000 1.000
1902119001 19B Coriander, seed

- babyfood 10.380000 1.000 1.000
1902143000 19B Dill, seed 10.380000 1.000 1.000

1901144000 19A Dillweed 10.380000 1.000 1.000
1901184000 19A Herbs, other 10.380000 1.000 1.000
1901184001 19A Herbs, other

- babyfood 10.380000 1.000 1.000 1901202000 19A Lemongrass 10.380000 1.000 1.00 0 1901220000 19A Marjoram 10.380000 1.000 1.000 1901220001 19A Marjoram

- babyfood 10.380000 1.000 1.000

### Carfentrazone

- ethyl (128712) Dietary Exposure and Risk Assessment D428859

Page 19 of 20 1901249000 19A Parsley, dried leaves 10.380000 1.000 1.000

1901249001 19A Parsl ey, dried leaves

- babyfood 10.380000 1.000 1.000 1902274000 19B Pepper, black and white 10.380000 1.000 1.000 1902274001 19B Pepper, black and white

- babyfood 10.380000 1.000 1.000 1901334000 19A Savory 10.380000 1.000 1.000 1902354000 19B Spices, other 10.380000 1.000 1.000 1902354001 19B Spices, other

- babyfood 10.380000 1.000 1.000
2003114001 20C Coconut, oil

- babyfood 0.710000 1.000 1.000
2003128000 20C Cottonseed, oil 1.000000 1.000 1.000
2003128001 20C Cottonseed, oil

- babyfood 1.000000 1.000 1.000

2001163000 20A Flax seed , oil 0.710000 1.000 1.000 2001319000 20A Rapeseed, oil 0.710000 1.000 1.000 2001319001 20A Rapeseed, oil

- babyfood 0.710000 1.000 1.000
2002330000 20B Safflower, oil 0.710000 1.000 1.000
2002330001 20B Safflower, oil

- babyfood 0.710000 1.000 1.000
2001337000 20A Sesame, oil 0.710000 1.000 1.000
2001337001 20A Sesame, oil

- babyfood 0.710000 1.000 1.000
2001336000 20A Sesame, seed 0.710000 1.000 1.000
2001336001 20A Sesame, seed

- babyfood 0.710000 1.000 1.000
2002365000 20B Sunflower, oil 0.710000 1.000 1.000

2002365001 20B Sunflow er, oil

- babyfood 0.710000 1.000 1.000
2002364000 20B Sunflower, seed 0.710000 1.000 1.000
3100047000 31 Beef, fat 0.100000 1.000 1.000
3100047001 31 Beef, fat

- babyfood 0.100000 1.000 1.000 3100048000 31 Beef, kidney 0.100000 1.000 1.000
3100049000 31 Beef, liver 0.100000 1.000 1.000
3100049001 31 Beef, liver

- babyfood 0.100000 1.000 1.00 0
3100044000 31 Beef, meat 0.100000 1.000 1.000 3100046000 31 Beef, meat byproducts 0.100000 1.000 1.000 3100046001 31 Beef, meat byproducts

- babyfood 0.100000 1.000 1.000
3100045000 31 Beef, meat, dried 0.100000 1.920 1.000
3100044001 31 Beef, meat

- babyfood 0.100000 1.000 1.000
3200171000 32 Goat, fat 0.100000 1.000 1.000 3200172000 32 Goat, kidney 0.100000 1.000 1.000
3200173000 32 Goat, liver 0.100000 1.000 1.000
3200169000 32 Goat, meat 0.100000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.100000 1.000 1.000
3300189000 33 Horse, meat 0.100000 1.000 1.000
3400293000 34 Pork, fat 0.100000 1.000 1.000
3400293001 34 Pork, fat

- babyfood 0.100000 1.000 1.000 3400294000 34 Pork, kidney 0.100000 1.000 1.000
3400295000 34 Pork, liver 0.100000 1.000 1.000
3400290000 34 Pork, meat 0.100000 1.000 1.000 3400292000 34 Pork, meat byproducts 0.100000 1.000 1.000 3400292001 34 Pork, meat byproducts

- babyfood 0.100000 1.000 1.000
3400290001 34 Pork, meat

- babyfood 0.100000 1.000 1.000
3400291000 34 Pork, skin 0.100000 1.000 1.000 3500341000 35 Sheep, fat 0.100000 1.000 1.000 3500341001 35 Sheep, fat

- babyfood 0.100000 1.000 1.000 3500342000 35 Sheep, kidney 0.100000 1.000 1.000 3500343000 35 Sheep, liver 0.100000 1.000 1.000 3500339000 35 Sheep, meat 0.100000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.100000 1.000 1.000 3500339001 35 Sheep, meat

- babyfood 0.100000 1.000 1.000
3600222000 36 Milk, fat 0.050000 1.000 1.000
3600222001 36 Milk, fat

- baby food/infant formu 0.050000 1.000 1.00 0
3600223000 36 Milk, nonfat solids 0.050000 1.000 1.000
3600223001 36 Milk, nonfat solids

- baby food/in 0.050000 1.000 1.000
3600225001 36 Milk, sugar (lactose)

- baby food/ 0.050000 1.000 1.000
3600224000 36 Milk, water 0.050000 1.000 1.000
3600224001 36 Milk, water

- babyfood/infant form 0.050000 1.000 1.000
3800221000 38 Meat, game 0.100000 1.000 1.000

### Carfentrazone

- ethyl (128712) Dietary Exposure and Risk Assessment D428859

Page 20 of 20 3900312000 39 Rabbit, meat 0.100000 1.000 1.000
4000094000 40 Chicken, liver 0.100000 1.000 1.000 4000095000 40 Chicken, meat byproducts 0.100000 1.000 1.000 4000095001 40 Chicken, meat byproducts

- babyfoo 0.100000 1.000 1.000 5000383000 50 Turkey, liver 0.100000 1.000 1.000 5000383001 50 Turkey, liver

- babyfood 0.100000 1.000 1.000 5000384000 50 Turkey, m eat byproducts 0.100000 1.000 1.000 5000384001 50 Turkey, meat byproducts

- babyfood 0.100000 1.000 1.000 6000302000 60 Poultry, other, liver 0.100000 1.000 1.000 6000303000 60 Poultry, other, meat byproducts 0.100000 1.000 1.000

8000157000 80 Fish

- freshwater finfish 0.300000 1.000 1.000

8000158000 80 Fish

- freshwater finfish, farm ra 0.300000 1.000 1.000

8000160000 80 Fish

- saltwater finfish, other 0.300000 1.000 1.000

8000159000 80 Fish

- saltwater finfish, tuna 0.300000 1.000 1.000

8000161000 80 Fish

- shellfish, crustacean 0.300000 1.000 1.000

8000162000 80 Fish

- shellfish, mollusc 0.300000 1.000 1.000
8601000000 86A Water, direct, all sources 0.086000 1.000 1.000
8602000000 86B Water, indirect, all sources 0.086000 1.000 1.000