### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 140−66−9 : 4−(1,1,3,3−Tetramethylbutyl)phenol Chemical QC [ N.D. P P P ]

Concentration (uM)Efficacy − fraction(E2) Agonist: Inactive Antagonist: Antagonist



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 140−66−9 : 4−(1,1,3,3−Tetramethylbutyl)phenol Agonist: 0.024 Antagonist: 0.036

Concentration (uM)Receptor Score Agonist: Inactive Antagonist: Antagonist



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 80−05−7 : Bisphenol A Chemical QC [ P P P P ]

Concentration (uM)Efficacy − fraction(E2) Agonist: Inactive Antagonist: Antagonist



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 80−05−7 : Bisphenol A Agonist: 0 Antagonist: 0.14

Concentration (uM)Receptor Score Agonist: Inactive Antagonist: Antagonist



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 56−53−1 : Diethylstilbestrol Chemical QC [ P P P ]

Concentration (uM)Efficacy − fraction(E2) Agonist: Inactive Antagonist: Antagonist



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 56−53−1 : Diethylstilbestrol Agonist: 0 Antagonist: 0.1

Concentration (uM)Receptor Score Agonist: Inactive Antagonist: Antagonist

### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 13311−84−7 : Flutamide Chemical QC [ N.D. P P P P ]

Concentration (uM)Efficacy − fraction(E2) Agonist: Inactive Antagonist: Antagonist



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 13311−84−7 : Flutamide Agonist: 0 Antagonist: 0.23

Concentration (uM)Receptor Score Agonist: Inactive Antagonist: Antagonist



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 52806−53−8 : Hydroxyflutamide Chemical QC [ P P P ]

Concentration (uM)Efficacy − fraction(E2) Agonist: Inactive Antagonist: Antagonist



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 52806−53−8 : Hydroxyflutamide Agonist: 0 Antagonist: 0.55

Concentration (uM)Receptor Score Agonist: Inactive Antagonist: Antagonist



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 72−55−9 : p,p'−DDE Chemical QC [ N.D. N.D. N.D. ]

Concentration (uM)Efficacy − fraction(E2) Agonist: Inactive Antagonist: Antagonist



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 72−55−9 : p,p'−DDE Agonist: 0.042 Antagonist: 0.064

Concentration (uM)Receptor Score Agonist: Inactive Antagonist: Antagonist

### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 32809−16−8 : Procymidone Chemical QC [ P P P ]

Concentration (uM)Efficacy − fraction(E2) Agonist: Inactive Antagonist: Antagonist



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 32809−16−8 : Procymidone Agonist: 0 Antagonist: 0.17

Concentration (uM)Receptor Score Agonist: Inactive Antagonist: Antagonist



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 50471−44−8 : Vinclozolin Chemical QC [ N.D. N.D. N.D. P ]

Concentration (uM)Efficacy − fraction(E2) Agonist: Inactive Antagonist: Antagonist



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 50471−44−8 : Vinclozolin Agonist: 0 Antagonist: 0.2

Concentration (uM)Receptor Score Agonist: Inactive Antagonist: Antagonist



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 63−05−8 : 4−Androstene−3,17−dione Chemical QC [ N.D. P P P P ]

Concentration (uM)Efficacy − fraction(E2) Agonist: Agonist Antagonist: Inactive



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 63−05−8 : 4−Androstene−3,17−dione Agonist: 0.83 Antagonist: 0

Concentration (uM)Receptor Score Agonist: Agonist Antagonist: Inactive

### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 521−18−6 : 5alpha−Dihydrotestosterone Chemical QC [ P P P P ]

Concentration (uM)Efficacy − fraction(E2) Agonist: Agonist Antagonist: Inactive



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 521−18−6 : 5alpha−Dihydrotestosterone Agonist: 1.1 Antagonist: 0

Concentration (uM)Receptor Score Agonist: Agonist Antagonist: Inactive



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 2392−39−4 : Dexamethasone sodium phosphate Chemical QC [ N.D. P P ]

Concentration (uM)Efficacy − fraction(E2) Agonist: Agonist Antagonist: Inactive



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 2392−39−4 : Dexamethasone sodium phosphate Agonist: 0.22 Antagonist: 0

Concentration (uM)Receptor Score Agonist: Agonist Antagonist: Inactive



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 58−18−4 : 17−Methyltestosterone Chemical QC [ N.D. P P P P ]

Concentration (uM)Efficacy − fraction(E2) Agonist: Agonist Antagonist: Inactive



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 58−18−4 : 17−Methyltestosterone Agonist: 1.1 Antagonist: 0

Concentration (uM)Receptor Score Agonist: Agonist Antagonist: Inactive

### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 57−85−2 : Testosterone propionate Chemical QC [ N.D. P P P ]

Concentration (uM)Efficacy − fraction(E2) Agonist: Agonist Antagonist: Inactive



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 57−85−2 : Testosterone propionate Agonist: 1 Antagonist: 0

Concentration (uM)Receptor Score Agonist: Agonist Antagonist: Inactive



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 50−28−2 : 17beta−Estradiol Chemical QC [ P P P P ]

Concentration (uM)Efficacy − fraction(E2) Agonist: SARM Antagonist: SARM



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 50−28−2 : 17beta−Estradiol Agonist: 0.79 Antagonist: 0.06

Concentration (uM)Receptor Score Agonist: SARM Antagonist: SARM



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 427−51−0 : Cyproterone acetate Chemical QC [ N.D. P P P P ]

Concentration (uM)Efficacy − fraction(E2) Agonist: SARM Antagonist: SARM



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 427−51−0 : Cyproterone acetate Agonist: 0.26 Antagonist: 0.069

Concentration (uM)Receptor Score Agonist: SARM Antagonist: SARM

### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 53−16−7 : Estrone Chemical QC [ N.D. P P P P ]

Concentration (uM)Efficacy − fraction(E2) Agonist: SARM Antagonist: SARM



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 53−16−7 : Estrone Agonist: 0.074 Antagonist: 0.26

Concentration (uM)Receptor Score Agonist: SARM Antagonist: SARM



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 206−44−0 : Fluoranthene Chemical QC [ N.D. N.D. N.D. ]

Concentration (uM)Efficacy − fraction(E2) Agonist: SARM Antagonist: SARM



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 206−44−0 : Fluoranthene Agonist: 0 Antagonist: 0

Concentration (uM)Receptor Score Agonist: SARM Antagonist: SARM



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 330−55−2 : Linuron Chemical QC [ P P P P ]

Concentration (uM)Efficacy − fraction(E2) Agonist: SARM Antagonist: SARM



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 330−55−2 : Linuron Agonist: 0 Antagonist: 0.044

Concentration (uM)Receptor Score Agonist: SARM Antagonist: SARM

### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 57−83−0 : Progesterone Chemical QC [ P P P P ]

Concentration (uM)Efficacy − fraction(E2) Agonist: SARM Antagonist: SARM



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 57−83−0 : Progesterone Agonist: 0.56 Antagonist: 0.077

Concentration (uM)Receptor Score Agonist: SARM Antagonist: SARM



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 52−01−7 : Spironolactone Chemical QC [ N.D. N.D. N.D. ]

Concentration (uM)Efficacy − fraction(E2) Agonist: SARM Antagonist: SARM



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 52−01−7 : Spironolactone Agonist: 0.054 Antagonist: 0.29

Concentration (uM)Receptor Score Agonist: SARM Antagonist: SARM



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 1912−24−9 : Atrazine Chemical QC [ P P P P ]

Concentration (uM)Efficacy − fraction(E2) Agonist: Inactive Antagonist: Inactive



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 1912−24−9 : Atrazine Agonist: 0 Antagonist: 0

Concentration (uM)Receptor Score Agonist: Inactive Antagonist: Inactive

### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 117−81−7 : Di(2−ethylhexyl) phthalate Chemical QC [ P P P ]

Concentration (uM)Efficacy − fraction(E2) Agonist: Inactive Antagonist: Inactive



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 117−81−7 : Di(2−ethylhexyl) phthalate Agonist: 0 Antagonist: 0

Concentration (uM)Receptor Score Agonist: Inactive Antagonist: Inactive



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 84−74−2 : Dibutyl phthalate Chemical QC [ P P P P P ]

Concentration (uM)Efficacy − fraction(E2) Agonist: Inactive Antagonist: Inactive



### 1e−02 1e−01 1e+00 1e+01 1e+020.00.20.40.60.81.0 

### 84−74−2 : Dibutyl phthalate Agonist: 0 Antagonist: 0

Concentration (uM)Receptor Score Agonist: Inactive Antagonist: Inactive