Material Safety Data Sheet 

Genetron® 32 

Version 2 Revision Date 12/15/2009 Print Date 03/28/2014 

Page 1 / 11 

SECTION 1. PRODUCT AND COMPANY IDENTIFICATION 

Product name : Genetron® 32 

MSDS Number : 000000009907 

Product Use Description : Refrigerant 

Company : Honeywell International, Inc. 

101 Columbia Road 

Morristown, NJ 07962-1057 

For more information call : 800-522-8001 

 (Monday-Friday, 9:00am-5:00pm) 

In case of emergency call : Medical: 1-800-498-5701 

: Transportation: 1-800-424-9300 or +1-703-527-3887 

 : (24 hours/day, 7 days/week) 

SECTION 2. HAZARDS IDENTIFICATION 

Emergency Overview 

Form : Liquefied gas 

Color : colourless 

Odor : slight sweet ether-like 

Hazard Summary : Warning! Container under pressure. Flammable. Gas reduces 

oxygen available for breathing. Causes asphyxiation in high 

concentrations. The victim will not realize that he/she is 

suffocating. Inhalation may cause central nervous system 

effects. May cause cardiac arrhythmia. May cause drowsiness 

and dizziness. Do not breathe vapour. Irritating to eyes and 

skin. Avoid contact with skin, eyes and clothing. At higher 

temperatures, (>250 C), decomposition products may include 

hydrofluoric acid (HF) and carbonyl halides. The ACGIH 

Threshold Limit Values (2007) for Hydrogen Fluoride are TLVTWA 0.5 ppm and Ceiling Exposure Limit 2 ppm. 

Potential Health Effects 

Skin : Avoid skin contact with leaking liquid (danger of frostbite).

May cause frostbite.

Irritating to skin.

Eyes : Causes serious eye irritation.
Material Safety Data Sheet 

Genetron® 32 

Version 2 Revision Date 12/15/2009 Print Date 03/28/2014 

Page 2 / 11 

May cause frostbite.

Ingestion : Unlikely route of exposure.

Effects due to ingestion may include:

Gastrointestinal discomfort

Inhalation : Gas reduces oxygen available for breathing.

Causes asphyxiation in high concentrations. The victim will 

not realize that he/she is suffocating.

Inhalation may cause central nervous system effects.

May cause cardiac arrhythmia.

Vapours may cause drowsiness and dizziness.

Chronic Exposure : None known.

Carcinogenicity 

No component of this product present at levels greater than or equal to 0.1% is identified as a known 

or anticipated carcinogen by NTP, IARC, or OSHA. 

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS 

Component CAS-No. Weight percent 

Difluoromethane 75-10-5 100.00 

SECTION 4. FIRST AID MEASURES 

Inhalation : Move to fresh air. If breathing is irregular or stopped, 

administer artificial respiration. Use oxygen as required, 

provided a qualified operator is present. Call a physician. Do 

not give drugs from adrenaline-ephedrine group. 

Skin contact : After contact with skin, wash immediately with plenty of water. 

If there is evidence of frostbite, bathe (do not rub) with 

lukewarm (not hot) water. If water is not available, cover with a 

clean, soft cloth or similar covering. If symptoms persist, call a 

physician. 

Eye contact : Remove contact lenses. Rinse immediately with plenty of 

water, also under the eyelids, for at least 15 minutes. 

Ingestion : Unlikely route of exposure. As this product is a gas, refer to the 

inhalation section. Do not induce vomiting without medical 

advice. Call a physician immediately. 
Material Safety Data Sheet 

Genetron® 32 

Version 2 Revision Date 12/15/2009 Print Date 03/28/2014 

Page 3 / 11 

Notes to physician 

Treatment : Because of the possible disturbances of cardiac rhythm, 

catecholamine drugs, such as epinephrine, should be used 

with special caution and only in situations of emergency life 

support. Treatment of overexposure should be directed at the 

control of symptoms and the clinical conditions. Treat frostbitten areas as needed. 

Treatment : Do not give adrenaline or similar drugs. 

SECTION 5. FIRE-FIGHTING MEASURES 

Flash point : not applicable

Ignition temperature : >750 °C (1,382 °F)

Lower explosion limit : 14.4 %(V)

Upper explosion limit : 33.4 %(V) 

Suitable extinguishing 

media 

: Use water spray, alcohol-resistant foam, dry chemical or 

carbon dioxide.

Use extinguishing measures that are appropriate to local 

circumstances and the surrounding environment.

Specific hazards during fire 

fighting 

: Contents under pressure.

Flammable.

Flash back possible over considerable distance.

Container may rupture on heating.

Cool closed containers exposed to fire with water spray.

Do not allow run-off from fire fighting to enter drains or water 

courses.

Vapours are heavier than air and can cause suffocation by 

reducing oxygen available for breathing.

Rapid evaporation of the liquid may cause frostbite.

In case of fire hazardous decomposition products may be 

produced such as:

Hydrogen fluoride

Carbon monoxide

Carbon dioxide (CO2)

Carbonyl halides

Special protective 

equipment for fire-fighters 

: In the event of fire and/or explosion do not breathe fumes.

Wear self-contained breathing apparatus and protective suit.

No unprotected exposed skin areas.
Material Safety Data Sheet 

Genetron® 32 

Version 2 Revision Date 12/15/2009 Print Date 03/28/2014 

Page 4 / 11 

SECTION 6. ACCIDENTAL RELEASE MEASURES 

Personal precautions : Immediately evacuate personnel to safe areas.

Keep people away from and upwind of spill/leak.

Wear personal protective equipment. Unprotected persons 

must be kept away.

Remove all sources of ignition.

Avoid skin contact with leaking liquid (danger of frostbite).

Ventilate the area.

After release, disperses into the air.

Vapours are heavier than air and can cause suffocation by 

reducing oxygen available for breathing.

Avoid accumulation of vapours in low areas.

Unprotected personnel should not return until air has been 

tested and determined safe.

Ensure that the oxygen content is >= 19.5%.

Environmental precautions : Prevent further leakage or spillage if safe to do so.

The product evaporates readily.

Methods for cleaning up : Ventilate the area.

SECTION 7. HANDLING AND STORAGE 

Handling 

Handling : Handle with care.

Avoid inhalation of vapour or mist.

Do not get in eyes, on skin, or on clothing.

Wear personal protective equipment.

Use only in well-ventilated areas.

Pressurized container. Protect from sunlight and do not expose 

to temperatures exceeding 50 °C.

Keep away from heat/sparks/open flames/hot surfaces. - No 

smoking.

Follow all standard safety precautions for handling and use of 

compressed gas cylinders.

Protect cylinders from physical damage.

Do not puncture or drop cylinders, expose them to open flame 

or excessive heat.

Do not pierce or burn, even after use. Do not spray on a naked 

flame or any incandescent material.

Do not remove screw cap until immediately ready for use.

Always replace cap after use.

Handling : Open drum carefully as content may be under pressure.

The product should only be used in areas from which all naked 

lights and other sources of ignition have been excluded.
Material Safety Data Sheet 

Genetron® 32 

Version 2 Revision Date 12/15/2009 Print Date 03/28/2014 

Page 5 / 11 

Pressurized container. Protect from sunlight and do not expose 

to temperatures exceeding 50 °C.

Do not pierce or burn, even after use. Do not spray on a naked 

flame or any incandescent material.

Do not use in areas without adequate ventilation.

Contaminated equipment (brushes, rags) must be cleaned 

immediately with water.

Advice on protection 

against fire and explosion 

: Vapours may form explosive mixture with air.

Container hazardous when empty.

Keep product and empty container away from heat and 

sources of ignition.

The heavy vapours can overcome a considerable distance up 

to the source of ignition.

Take measures to prevent the build up of electrostatic charge.

Electrical equipment should be protected to the appropriate 

standard.

Storage 

Requirements for storage 

areas and containers 

: Keep containers tightly closed in a dry, cool and well-ventilated 

place.

Pressurized container: Protect from sunlight and do not expose 

to temperatures exceeding 50 °C. Do not pierce or burn, even 

after use.

Keep away from heat and sources of ignition.

Protect cylinders from physical damage.

Store away from incompatible substances.

Storage rooms must be properly ventilated.

Ensure adequate ventilation, especially in confined areas.

Further information on 

storage conditions 

: Store in original container.

Keep containers tightly closed in a cool, well-ventilated place.

Keep away from direct sunlight.

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Protective measures : Do not breathe vapour.

Avoid contact with skin, eyes and clothing.

Ensure that eyewash stations and safety showers are close to 

the workstation location.

Engineering measures : General room ventilation is adequate for storage and handling.

Perform filling operations only at stations with exhaust 

ventilation facilities.
Material Safety Data Sheet 

Genetron® 32 

Version 2 Revision Date 12/15/2009 Print Date 03/28/2014 

Page 6 / 11 

Eye protection : Do not wear contact lenses.

Wear as appropriate:

Safety glasses with side-shields

If splashes are likely to occur, wear:

Goggles or face shield, giving complete protection to eyes

Hand protection : Leather gloves

In case of contact through splashing:

Protective gloves

Neoprene gloves

Polyvinyl alcohol or nitrile- butyl-rubber gloves

Skin and body protection : Avoid skin contact with leaking liquid (danger of frostbite).

Wear cold insulating gloves/face shield/eye protection.

Respiratory protection : In case of insufficient ventilation wear suitable respiratory 

equipment.

Wear a positive-pressure supplied-air respirator.

Vapours are heavier than air and can cause suffocation by 

reducing oxygen available for breathing.

For rescue and maintenance work in storage tanks use selfcontained breathing apparatus.

Hygiene measures : Handle in accordance with good industrial hygiene and safety 

practice.

Ensure adequate ventilation, especially in confined areas.

Avoid contact with skin, eyes and clothing.

Remove and wash contaminated clothing before re-use.

Keep working clothes separately.

Exposure Guidelines

Difluoromethane 75-10-5 WEEL TWA 1,000 ppm 2,200 

mg/m3

 TX ESL ST ESL 10600 ug/m3

 HONEYWELL TWA 1,000 ppm

 TX ESL AN ESL 1060 ug/m3

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES 

Form : Liquefied gas 

Color : colourless 

Odor : slight sweet ether-like 
Material Safety Data Sheet 

Genetron® 32 

Version 2 Revision Date 12/15/2009 Print Date 03/28/2014 

Page 7 / 11 

Molecular Weight : 52 g/mol 

pH : neutral

Freezing point : -136 °C (-213 °F)

Boiling point/boiling range : -51.7 °C (-61.1 °F)

Vapor pressure : 15,189 hPa 

at 21.1 °C (70.0 °F) 

Vapor pressure : 34,804 hPa 

at 54.4 °C (129.9 °F) 

Relative vapour density : 1.8 

(Air = 1.0) 

Density : 1.002 g/cm3 

at 26.7 °C (80.1 °F) 

Water solubility : insoluble 

Partition coefficient: noctanol/water : log Pow: 0.21

SECTION 10. STABILITY AND REACTIVITY 

Conditions to avoid : Protect from heat/overheating.

Decomposes under high temperature.

Contains gas under pressure; may explode if heated.

Keep away from heat/sparks/open flames/hot surfaces. - No 

smoking.

Keep away from direct sunlight.

Some risk may be expected of corrosive and toxic 

decomposition products.

 

Materials to avoid : Finely divided aluminium

Potassium

Calcium

Powdered metals

Aluminium

Magnesium

Zinc

Hazardous decomposition 

products 

: Halogenated compounds

Hydrogen fluoride

Carbonyl halides

Carbon oxides
Material Safety Data Sheet 

Genetron® 32 

Version 2 Revision Date 12/15/2009 Print Date 03/28/2014 

Page 8 / 11 

Thermal decomposition : >250 °C

To avoid thermal decomposition, do not overheat.

Hazardous reactions : Hazardous polymerisation does not occur.

Stable under normal conditions.

SECTION 11. TOXICOLOGICAL INFORMATION 

Acute inhalation toxicity : LC50 rat 

Dose: > 520000 ppm 

Exposure time: 4 h 

Sensitisation : Cardiac sensitization dogs 

No-observed-effect level 

>350,000 ppm 

Repeated dose toxicity : Inhalation rat Subchronic toxicity 

NOEL: 50,000 ppm 

Genotoxicity in vitro : Ames test 

negative 

Genotoxicity in vitro : Human lymphocytes 

negative 

Mutagenicity (in vitro mammalian cytogenetic test) 

Genotoxicity in vitro : Chromosome aberration test in vitro 

negative 

Genotoxicity in vivo : Species: mouse 

Cell type: Bone marrow 

Mutagenicity (micronucleus test) 

negative 

Teratogenicity : rat 

NOEL - 50,000 ppm 

Teratogenicity : rabbit 

NOEL - 50,000 ppm 

SECTION 12. ECOLOGICAL INFORMATION 

Biodegradability : Minimal 
Material Safety Data Sheet 

Genetron® 32 

Version 2 Revision Date 12/15/2009 Print Date 03/28/2014 

Page 9 / 11 

Additional ecological 

information 

: This product is subject to U.S. Environmental Protection 

Agency Clean Air Act Regulations at 40 CFR Part 82. 

This product contains greenhouse gases which may contribute 

to global warming. Do NOT vent to the atmosphere. To comply 

with provisions of the U.S. Clean Air Act, any residual must be 

recovered. 

SECTION 13. DISPOSAL CONSIDERATIONS 

Waste Information: Observe all Federal, State, and Local Environmental regulations. 

Additional advice : This product is subject to U.S. Environmental Protection 

Agency Clean Air Act Regulations Section 608 in 40 CFR Part 

82 regarding refrigerant recycling. 

SECTION 14. TRANSPORT INFORMATION 

DOT UN-Number : 3252

Proper shipping name : DIFLUOROMETHANE 

Class 2.1 

Packing group 

Hazard Labels 2.1

IATA UN Number : 3252 

Description of the goods : DIFLUOROMETHANE 

Class : 2.1 

Hazard Labels : 2.1 

Packing instruction (cargo 

aircraft) 

: 200 

IMDG Substance No. : UN 3252 

Description of the goods : DIFLUOROMETHANE 

Class : 2.1 

Hazard Labels : 2.1 

EmS Number : F-D 

Marine pollutant : no 

SECTION 15. REGULATORY INFORMATION 

Inventories 

1907/2006 (EU) : This mixture contains only ingredients which have been subject 

to a pre-registration according to Regulation (EC) No. 

1907/2006 (REACH). 

US. Toxic Substances : On TSCA Inventory 
Material Safety Data Sheet 

Genetron® 32 

Version 2 Revision Date 12/15/2009 Print Date 03/28/2014 

Page 10 / 11 

Control Act 

Australia. Industrial 

Chemical (Notification and 

Assessment) Act 

: On the inventory, or in compliance with the inventory 

Canada. Canadian 

Environmental Protection 

Act (CEPA). Domestic 

Substances List (DSL). 

(Can. Gaz. Part II, Vol. 133) 

: All components of this product are on the Canadian DSL list. 

Japan. Kashin-Hou Law 

List 

: On the inventory, or in compliance with the inventory 

Korea. Toxic Chemical 

Control Law (TCCL) List 

: On the inventory, or in compliance with the inventory 

Philippines. The Toxic 

Substances and Hazardous 

and Nuclear Waste Control 

Act 

: On the inventory, or in compliance with the inventory 

China. Inventory of Existing 

Chemical Substances 

: On the inventory, or in compliance with the inventory 

New Zealand. Inventory of 

Chemicals (NZIoC), as 

published by ERMA New 

Zealand 

: On the inventory, or in compliance with the inventory 

National regulatory information 

SARA 311/312 Hazards : Fire Hazard 

Acute Health Hazard 

Sudden Release of Pressure Hazard 

California Prop. 65 : WARNING! This product contains a chemical known in the 

State of California to cause cancer. 

Dichloromethane 75-09-2 
Material Safety Data Sheet 

Genetron® 32 

Version 2 Revision Date 12/15/2009 Print Date 03/28/2014 

Page 11 / 11 

: WARNING! This product contains a chemical known in the 

State of California to cause birth defects or other reproductive 

harm. 

Chloromethane 74-87-3 

Massachusetts RTK : Dichloromethane 75-09-2 

New Jersey RTK : Difluoromethane 75-10-5 

Pennsylvania RTK : Difluoromethane 75-10-5 

WHMIS Classification : A

This product has been classified according to the hazard criteria 

of the CPR and the MSDS contains all of the information 

required by the CPR.

Global warming potential : 550 

SECTION 16. OTHER INFORMATION 

HMIS III NFPA

Health hazard : 1 2 

Flammability : 4 4 

Physical Hazard : 0 

Instability : 0 
Material Safety Data Sheet 

Genetron® 125 

Version 2 Revision Date 12/15/2009 Print Date 03/28/2014 

Page 1 / 10 

SECTION 1. PRODUCT AND COMPANY IDENTIFICATION 

Product name : Genetron® 125 

MSDS Number : 000000009884 

Product Use Description : Refrigerant 

Company : Honeywell International, Inc. 

101 Columbia Road 

Morristown, NJ 07962-1057 

For more information call : 800-522-8001 

 (Monday-Friday, 9:00am-5:00pm) 

In case of emergency call : Medical: 1-800-498-5701 

: Transportation: 1-800-424-9300 or +1-703-527-3887 

 : (24 hours/day, 7 days/week) 

SECTION 2. HAZARDS IDENTIFICATION 

Emergency Overview 

Form : Liquefied gas 

Color : colourless 

Odor : slight 

Hazard Summary : Warning! Container under pressure. This product is not 

flammable at ambient temperatures and atmospheric 

pressure. Gas reduces oxygen available for breathing. 

Causes asphyxiation in high concentrations. The victim will 

not realize that he/she is suffocating. Inhalation may cause 

central nervous system effects. May cause cardiac 

arrhythmia. May cause drowsiness and dizziness. Do not 

breathe vapour. Irritating to eyes and skin. Avoid contact with 

skin, eyes and clothing. At higher temperatures, (>250 C), 

decomposition products may include hydrofluoric acid (HF) 

and carbonyl halides. The ACGIH Threshold Limit Values 

(2007) for Hydrogen Fluoride are TLV-TWA 0.5 ppm and 

Ceiling Exposure Limit 2 ppm. 

Potential Health Effects 

Skin : Avoid skin contact with leaking liquid (danger of frostbite).

May cause frostbite.

Irritating to skin.
Material Safety Data Sheet 

Genetron® 125 

Version 2 Revision Date 12/15/2009 Print Date 03/28/2014 

Page 2 / 10 

Eyes : Causes serious eye irritation.

May cause frostbite.

Ingestion : Unlikely route of exposure.

Effects due to ingestion may include:

Gastrointestinal discomfort

Inhalation : Gas reduces oxygen available for breathing.

Causes asphyxiation in high concentrations. The victim will 

not realize that he/she is suffocating.

Inhalation may cause central nervous system effects.

May cause cardiac arrhythmia.

Vapours may cause drowsiness and dizziness.

Chronic Exposure : None known.

Carcinogenicity 

No component of this product present at levels greater than or equal to 0.1% is identified as a known 

or anticipated carcinogen by NTP, IARC, or OSHA. 

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS 

Component CAS-No. Weight percent 

Pentafluoroethane 354-33-6 100.00 

SECTION 4. FIRST AID MEASURES 

Inhalation : Move to fresh air. If breathing is irregular or stopped, 

administer artificial respiration. Use oxygen as required, 

provided a qualified operator is present. Call a physician. Do 

not give drugs from adrenaline-ephedrine group. 

Skin contact : After contact with skin, wash immediately with plenty of water. 

If there is evidence of frostbite, bathe (do not rub) with 

lukewarm (not hot) water. If water is not available, cover with a 

clean, soft cloth or similar covering. If symptoms persist, call a 

physician. 

Eye contact : Rinse immediately with plenty of water, also under the eyelids, 

for at least 15 minutes. In case of frostbite water should be 

lukewarm, not hot. If symptoms persist, call a physician. 

Ingestion : Unlikely route of exposure. As this product is a gas, refer to the 

inhalation section. Do not induce vomiting without medical 
Material Safety Data Sheet 

Genetron® 125 

Version 2 Revision Date 12/15/2009 Print Date 03/28/2014 

Page 3 / 10 

advice. Call a physician immediately. 

Notes to physician 

Treatment : Because of the possible disturbances of cardiac rhythm, 

catecholamine drugs, such as epinephrine, should be used 

with special caution and only in situations of emergency life 

support. Treatment of overexposure should be directed at the 

control of symptoms and the clinical conditions. Treat frostbitten areas as needed. 

SECTION 5. FIRE-FIGHTING MEASURES 

Flash point : not applicable

Ignition temperature : >750 °C (1,382 °F)

Lower explosion limit : None

Upper explosion limit : None 

Suitable extinguishing 

media 

: The product is not flammable.

ASHRAE 34

Use water spray, alcohol-resistant foam, dry chemical or 

carbon dioxide.

Use extinguishing measures that are appropriate to local 

circumstances and the surrounding environment.

Specific hazards during fire 

fighting 

: Contents under pressure.

This product is not flammable at ambient temperatures and 

atmospheric pressure.

However, this material can ignite when mixed with air under 

pressure and exposed to strong ignition sources.

Container may rupture on heating.

Cool closed containers exposed to fire with water spray.

Do not allow run-off from fire fighting to enter drains or water 

courses.

Vapours are heavier than air and can cause suffocation by 

reducing oxygen available for breathing.

In case of fire hazardous decomposition products may be 

produced such as:

Hydrogen halides

Hydrogen fluoride

Carbon monoxide

Carbon dioxide (CO2)

Carbonyl halides
Material Safety Data Sheet 

Genetron® 125 

Version 2 Revision Date 12/15/2009 Print Date 03/28/2014 

Page 4 / 10 

Special protective 

equipment for fire-fighters 

: In the event of fire and/or explosion do not breathe fumes.

Wear self-contained breathing apparatus and protective suit.

No unprotected exposed skin areas.

SECTION 6. ACCIDENTAL RELEASE MEASURES 

Personal precautions : Immediately evacuate personnel to safe areas.

Keep people away from and upwind of spill/leak.

Wear personal protective equipment. Unprotected persons 

must be kept away.

Remove all sources of ignition.

Avoid skin contact with leaking liquid (danger of frostbite).

Ventilate the area.

After release, disperses into the air.

Vapours are heavier than air and can cause suffocation by 

reducing oxygen available for breathing.

Avoid accumulation of vapours in low areas.

Unprotected personnel should not return until air has been 

tested and determined safe.

Ensure that the oxygen content is >= 19.5%.

Environmental precautions : Prevent further leakage or spillage if safe to do so.

The product evaporates readily.

Methods for cleaning up : Ventilate the area.

SECTION 7. HANDLING AND STORAGE 

Handling 

Handling : Handle with care.

Avoid inhalation of vapour or mist.

Do not get in eyes, on skin, or on clothing.

Wear personal protective equipment.

Use only in well-ventilated areas.

Pressurized container. Protect from sunlight and do not expose 

to temperatures exceeding 50 °C.

Follow all standard safety precautions for handling and use of 

compressed gas cylinders.

Use authorized cylinders only.

Protect cylinders from physical damage.

Do not puncture or drop cylinders, expose them to open flame 

or excessive heat.

Do not pierce or burn, even after use. Do not spray on a naked 

flame or any incandescent material.

Do not remove screw cap until immediately ready for use.

Always replace cap after use.
Material Safety Data Sheet 

Genetron® 125 

Version 2 Revision Date 12/15/2009 Print Date 03/28/2014 

Page 5 / 10 

Advice on protection 

against fire and explosion 

: The product is not flammable.

Can form a combustible mixture with air at pressures above 

atmospheric pressure.

Storage 

Requirements for storage 

areas and containers 

: Pressurized container: Protect from sunlight and do not expose 

to temperatures exceeding 50 °C. Do not pierce or burn, even 

after use.

Keep containers tightly closed in a dry, cool and well-ventilated 

place.

Storage rooms must be properly ventilated.

Ensure adequate ventilation, especially in confined areas.

Protect cylinders from physical damage.

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Protective measures : Do not breathe vapour.

Avoid contact with skin, eyes and clothing.

Ensure that eyewash stations and safety showers are close to 

the workstation location.

Engineering measures : General room ventilation is adequate for storage and handling.

Perform filling operations only at stations with exhaust 

ventilation facilities.

Eye protection : Wear as appropriate:

Safety glasses with side-shields

If splashes are likely to occur, wear:

Goggles or face shield, giving complete protection to eyes

Hand protection : Leather gloves

In case of contact through splashing:

Protective gloves

Neoprene gloves

Polyvinyl alcohol or nitrile- butyl-rubber gloves

Skin and body protection : Avoid skin contact with leaking liquid (danger of frostbite).

Wear cold insulating gloves/face shield/eye protection.

Respiratory protection : In case of insufficient ventilation, wear suitable respiratory 

equipment.

Wear a positive-pressure supplied-air respirator.

Vapours are heavier than air and can cause suffocation by 

reducing oxygen available for breathing.

For rescue and maintenance work in storage tanks use selfcontained breathing apparatus.
Material Safety Data Sheet 

Genetron® 125 

Version 2 Revision Date 12/15/2009 Print Date 03/28/2014 

Page 6 / 10 

Hygiene measures : Handle in accordance with good industrial hygiene and safety 

practice.

Ensure adequate ventilation, especially in confined areas.

Avoid contact with skin, eyes and clothing.

Remove and wash contaminated clothing before re-use.

Keep working clothes separately.

Exposure Guidelines

Pentafluoroethane 354-33-6 WEEL TWA 1,000 ppm 4,900 

mg/m3

 HONEYWELL TWA 1,000 ppm

 TX ESL AN ESL 2450 ug/m3

 TX ESL ST ESL 24500 ug/m3

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES 

Form : Liquefied gas 

Color : colourless 

Odor : slight 

Molecular Weight : 120.03 g/mol 

Melting point/range : -103 °C (-153 °F)

Boiling point/boiling range : -48.5 °C (-55.3 °F)

Vapor pressure : 12,438 hPa 

at 21.1 °C (70.0 °F) 

Vapor pressure : 28,110 hPa 

at 54.4 °C (129.9 °F) 

Relative vapour density : 4.2 

(Air = 1.0) 

Density : 1.21 g/cm3 

at 21.1 °C (70.0 °F) 

Water solubility : 0.9 g/l 

Partition coefficient: noctanol/water : log Pow: 1.48
Material Safety Data Sheet 

Genetron® 125 

Version 2 Revision Date 12/15/2009 Print Date 03/28/2014 

Page 7 / 10 

The product is more soluble in octanol. 

SECTION 10. STABILITY AND REACTIVITY 

Conditions to avoid : Pressurized container. Protect from sunlight and do not 

expose to temperatures exceeding 50 °C.

Decomposes under high temperature.

Some risk may be expected of corrosive and toxic 

decomposition products.

Can form a combustible mixture with air at pressures above 

atmospheric pressure.

Do not mix with oxygen or air above atmospheric pressure.

 

Materials to avoid : Finely divided aluminium

Potassium

Calcium

Powdered metals

Aluminium

Magnesium

Zinc

Hazardous decomposition 

products 

: In case of fire hazardous decomposition products may be 

produced such as:

Halogenated compounds

Hydrogen fluoride

Carbonyl halides

Carbon monoxide

Carbon dioxide (CO2)

Thermal decomposition : >250 °C

To avoid thermal decomposition, do not overheat.

Hazardous reactions : Hazardous polymerisation does not occur.

Stable under normal conditions.

SECTION 11. TOXICOLOGICAL INFORMATION 

Acute inhalation toxicity : rat 

Dose: > 769000 ppm 

Exposure time: 4 h 

Sensitisation : Cardiac sensitization dogs 

No-observed-effect level 

75,000 ppm 

Lowest observable effect level 

100,000 ppm 
Material Safety Data Sheet 

Genetron® 125 

Version 2 Revision Date 12/15/2009 Print Date 03/28/2014 

Page 8 / 10 

Repeated dose toxicity : Inhalation rat Subchronic toxicity 

NOEL: >= 50000 ppm 

Genotoxicity in vitro : In vitro tests did not show mutagenic effects 

Additional advice : Vapours are heavier than air and can cause suffocation by 

reducing oxygen available for breathing. 

Irritating to eyes and skin. 

Rapid evaporation of the liquid may cause frostbite. 

Avoid skin contact with leaking liquid (danger of frostbite). 

May cause cardiac arrhythmia. 

SECTION 12. ECOLOGICAL INFORMATION 

Additional ecological 

information 

: Accumulation in aquatic organisms is unlikely. 

This product contains greenhouse gases which may contribute 

to global warming. Do NOT vent to the atmosphere. To comply 

with provisions of the U.S. Clean Air Act, any residual must be 

recovered. 

SECTION 13. DISPOSAL CONSIDERATIONS 

Waste Information: Observe all Federal, State, and Local Environmental regulations. 

Additional advice : This product is subject to U.S. Environmental Protection 

Agency Clean Air Act Regulations Section 608 in 40 CFR Part 

82 regarding refrigerant recycling. 

SECTION 14. TRANSPORT INFORMATION 

DOT UN-Number : 3220

Proper shipping name : PENTAFLUOROETHANE 

Class 2.2 

Packing group 

Hazard Labels 2.2

IATA UN Number : 3220 

Description of the goods : PENTAFLUOROETHANE 

Class : 2.2 

Hazard Labels : 2.2 

Packing instruction (cargo 

aircraft) 

: 200 
Material Safety Data Sheet 

Genetron® 125 

Version 2 Revision Date 12/15/2009 Print Date 03/28/2014 

Page 9 / 10 

Packing instruction 

(passenger aircraft) 

: 200 

IMDG Substance No. : UN 3220 

Description of the goods : PENTAFLUOROETHANE 

Class : 2.2 

Hazard Labels : 2.2 

EmS Number : F-C 

Marine pollutant : no 

SECTION 15. REGULATORY INFORMATION 

Inventories 

1907/2006 (EU) : This mixture contains only ingredients which have been subject 

to a pre-registration according to Regulation (EC) No. 

1907/2006 (REACH). 

US. Toxic Substances 

Control Act 

: On TSCA Inventory 

Australia. Industrial 

Chemical (Notification and 

Assessment) Act 

: On the inventory, or in compliance with the inventory 

Canada. Canadian 

Environmental Protection 

Act (CEPA). Domestic 

Substances List (DSL). 

(Can. Gaz. Part II, Vol. 133) 

: All components of this product are on the Canadian DSL list. 

Japan. Kashin-Hou Law 

List 

: On the inventory, or in compliance with the inventory 

Korea. Toxic Chemical 

Control Law (TCCL) List 

: On the inventory, or in compliance with the inventory 

Philippines. The Toxic 

Substances and Hazardous 

and Nuclear Waste Control 

Act 

: On the inventory, or in compliance with the inventory 

China. Inventory of Existing 

Chemical Substances 

: On the inventory, or in compliance with the inventory 

New Zealand. Inventory of 

Chemicals (NZIoC), as 

published by ERMA New 

Zealand 

: Not in compliance with the inventory 
Material Safety Data Sheet 

Genetron® 125 

Version 2 Revision Date 12/15/2009 Print Date 03/28/2014 

Page 10 / 10 

: Pentafluoroethane 354-33-6 

National regulatory information 

SARA 311/312 Hazards : Acute Health Hazard 

Sudden Release of Pressure Hazard 

California Prop. 65 : This product does not contain any chemicals known to the State 

of California to cause cancer, birth, or any other reproductive 

defects. 

WHMIS Classification : A

This product has been classified according to the hazard criteria 

of the CPR and the MSDS contains all of the information 

required by the CPR.

Global warming potential : 3,400 

Ozone depletion potential 

(ODP) 

: 0 

SECTION 16. OTHER INFORMATION 

HMIS III NFPA

Health hazard : 1 2 

Flammability : 1 1 

Physical Hazard : 0 

Instability : 0 
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SECTION 1. PRODUCT AND COMPANY IDENTIFICATION 

Product name : Genetron® 134a 

MSDS Number : 000000009876 

Product Use Description : Refrigerant, Propellant

Company : Honeywell International, Inc. 

101 Columbia Road 

Morristown, NJ 07962-1057 

For more information call : 800-522-8001 

+1-973-455-6300 

 (Monday-Friday, 9:00am-5:00pm) 

In case of emergency call : Medical: 1-800-498-5701 or +1-303-389-1414 

: Transportation (CHEMTREC): 1-800-424-9300 or +1-703-

527-3887 

: 

 : (24 hours/day, 7 days/week) 

SECTION 2. HAZARDS IDENTIFICATION 

Emergency Overview 

Form : Liquefied gas 

Color : colourless 

Odor : weak 

Hazard Summary : Warning! Container under pressure. This product is not 

flammable at ambient temperatures and atmospheric 

pressure. Gas reduces oxygen available for breathing. 

Causes asphyxiation in high concentrations. The victim will 

not realize that he/she is suffocating. Excessive exposure may 

cause central nervous system effects including drowsiness 

and dizziness. Excessive exposure may also cause cardiac 

arrhythmia. Do not breathe vapour. Rapid evaporation of the 

liquid may cause frostbite. Avoid contact with skin, eyes and 
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clothing. At higher temperatures, (>250 C), decomposition 

products may include hydrofluoric acid (HF) and carbonyl 

halides. The ACGIH Threshold Limit Values (2007) for 

Hydrogen Fluoride are TLV-TWA 0.5 ppm and Ceiling 

Exposure Limit 2 ppm. 

Potential Health Effects 

Skin : Avoid skin contact with leaking liquid (danger of frostbite).

May cause frostbite.

Irritating to skin.

Eyes : Causes serious eye irritation.

May cause frostbite.

Ingestion : Unlikely route of exposure.

Effects due to ingestion may include:

Gastrointestinal discomfort

Inhalation : Gas reduces oxygen available for breathing.

Causes asphyxiation in high concentrations. The victim will 

not realize that he/she is suffocating.

Excessive exposure may cause central nervous system 

effects including drowsiness and dizziness. Excessive 

exposure may also cause cardiac arrhythmia.

Chronic Exposure : None known.

Carcinogenicity 

No component of this product present at levels greater than or equal to 0.1% is identified as a known 

or anticipated carcinogen by NTP, IARC, or OSHA. 

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS 

Formula : CF3CH2F 

Chemical nature : Substance 

Chemical Name CAS-No. Concentration 
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1,1,1,2-Tetrafluoroethane 811-97-2 99.80 %

SECTION 4. FIRST AID MEASURES 

Inhalation : Move to fresh air. If breathing is irregular or stopped, 

administer artificial respiration. Use oxygen as required, 

provided a qualified operator is present. Call a physician. Do 

not give drugs from adrenaline-ephedrine group. 

Skin contact : After contact with skin, wash immediately with plenty of water. 

If there is evidence of frostbite, bathe (do not rub) with 

lukewarm (not hot) water. If water is not available, cover with a 

clean, soft cloth or similar covering. If symptoms persist, call a 

physician. 

Eye contact : Rinse immediately with plenty of water, also under the eyelids, 

for at least 15 minutes. In case of frostbite water should be 

lukewarm, not hot. If symptoms persist, call a physician. 

Ingestion : Unlikely route of exposure. As this product is a gas, refer to the 

inhalation section. Do not induce vomiting without medical 

advice. Call a physician immediately. 

Notes to physician 

Treatment : Because of the possible disturbances of cardiac rhythm, 

catecholamine drugs, such as epinephrine, should be used 

with special caution and only in situations of emergency life 

support. Treatment of overexposure should be directed at the 

control of symptoms and the clinical conditions. Treat frostbitten areas as needed. 

SECTION 5. FIREFIGHTING MEASURES 

Suitable extinguishing media : The product is not flammable. 

Use water spray, alcohol-resistant foam, dry chemical or 

carbon dioxide. 

Use extinguishing measures that are appropriate to local 

circumstances and the surrounding environment. 

Specific hazards during : Contents under pressure. 
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firefighting This product is not flammable at ambient temperatures and 

atmospheric pressure. 

However, this material can ignite when mixed with air under 

pressure and exposed to strong ignition sources. 

Container may rupture on heating. 

Cool closed containers exposed to fire with water spray. 

Do not allow run-off from fire fighting to enter drains or water 

courses. 

Vapours are heavier than air and can cause suffocation by 

reducing oxygen available for breathing. 

In case of fire hazardous decomposition products may be 

produced such as: 

Hydrogen halides 

Hydrogen fluoride 

Carbon monoxide 

Carbon dioxide (CO2) 

Carbonyl halides 

Special protective equipment 

for firefighters 

: In the event of fire and/or explosion do not breathe fumes. 

Wear self-contained breathing apparatus and protective suit. 

No unprotected exposed skin areas. 

SECTION 6. ACCIDENTAL RELEASE MEASURES 

Personal precautions : Immediately evacuate personnel to safe areas.

Keep people away from and upwind of spill/leak.

Wear personal protective equipment. Unprotected persons 

must be kept away.

Remove all sources of ignition.

Avoid skin contact with leaking liquid (danger of frostbite).

Ventilate the area.

After release, disperses into the air.

Vapours are heavier than air and can cause suffocation by 

reducing oxygen available for breathing.

Avoid accumulation of vapours in low areas.

Unprotected personnel should not return until air has been 

tested and determined safe.

Ensure that the oxygen content is >= 19.5%.

Environmental precautions : Prevent further leakage or spillage if safe to do so.

The product evaporates readily.
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Methods for cleaning up : Ventilate the area.

SECTION 7. HANDLING AND STORAGE 

Handling 

Handling : Handle with care.

Avoid inhalation of vapour or mist.

Do not get in eyes, on skin, or on clothing.

Wear personal protective equipment.

Use only in well-ventilated areas.

Pressurized container. Protect from sunlight and do not expose 

to temperatures exceeding 50 °C.

Follow all standard safety precautions for handling and use of 

compressed gas cylinders.

Use authorized cylinders only.

Protect cylinders from physical damage.

Do not puncture or drop cylinders, expose them to open flame 

or excessive heat.

Do not pierce or burn, even after use. Do not spray on a naked 

flame or any incandescent material.

Do not remove screw cap until immediately ready for use.

Always replace cap after use.

Advice on protection 

against fire and explosion 

: The product is not flammable.

Can form a combustible mixture with air at pressures above 

atmospheric pressure.

Storage 

Requirements for storage 

areas and containers 

: Pressurized container: protect from sunlight and do not expose 

to temperatures exceeding 50 °C. Do not pierce or burn, even 

after use.

Keep containers tightly closed in a dry, cool and well-ventilated 

place.

Storage rooms must be properly ventilated.

Ensure adequate ventilation, especially in confined areas.

Protect cylinders from physical damage.

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
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Protective measures : Do not breathe vapour.

Avoid contact with skin, eyes and clothing.

Ensure that eyewash stations and safety showers are close to 

the workstation location.

Engineering measures : General room ventilation is adequate for storage and handling.

Perform filling operations only at stations with exhaust 

ventilation facilities.

Eye protection : Wear as appropriate:

Safety glasses with side-shields

If splashes are likely to occur, wear:

Goggles or face shield, giving complete protection to eyes

Hand protection : Leather gloves

In case of contact through splashing:

Protective gloves

Neoprene gloves

Polyvinyl alcohol or nitrile- butyl-rubber gloves

Skin and body protection : Avoid skin contact with leaking liquid (danger of frostbite).

Wear cold insulating gloves/ face shield/ eye protection.

Respiratory protection : In case of insufficient ventilation, wear suitable respiratory 

equipment.

Wear a positive-pressure supplied-air respirator.

Vapours are heavier than air and can cause suffocation by 

reducing oxygen available for breathing.

For rescue and maintenance work in storage tanks use selfcontained breathing apparatus.

Hygiene measures : Handle in accordance with good industrial hygiene and safety 

practice.

Ensure adequate ventilation, especially in confined areas.

Avoid contact with skin, eyes and clothing.

Remove and wash contaminated clothing before re-use.

Keep working clothes separately.

Exposure Guidelines

Components CAS-No. Value Control 

parameters 

Upda

te 

Basis 
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1,1,1,2-

Tetrafluoroethane 

811-97-2 TWA :

time 

weighted 

average 

(1,000 ppm) Honeywell:Limit 

established by 

Honeywell 

International Inc.

1,1,1,2-

Tetrafluoroethane 

811-97-2 TWA :

time 

weighted 

average 

4,240 mg/m3 

(1,000 ppm) 

2007 WEEL:US. AIHA 

Workplace 

Environmental 

Exposure Level 

(WEEL) Guides

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES 

Physical state : Liquefied gas

Color : colourless 

Odor : weak 

pH : Note: neutral 

Melting point/freezing point : -101 °C 

Boiling point/boiling range : -26.2 °C 

Flash point : Note: not applicable 

Evaporation rate : > 1 

Method: Compared to CCl4. 

Lower explosion limit : Note: None 

Upper explosion limit : Note: None 

Vapor pressure : 5,915 hPa 
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at 21.1 °C(70.0 °F) 

 14,713 hPa 

at 54.4 °C(129.9 °F) 

Vapor density : 3.5 

Density : 1.2 g/cm3 

Water solubility : 1.5 g/l 

Partition coefficient: noctanol/water : log Pow: 1.06 

Note: The product is more soluble in octanol. 

Ignition temperature : > 750 °C 

Autoignition temperature : > 750 °C 

Decomposition temperature : > 250 °C 

Note: To avoid thermal decomposition, do not overheat. 

Molecular Weight : 102.02 g/mol 

Global warming potential 

(GWP) 

: 1,300

Ozone depletion potential 

(ODP) 

: 0

SECTION 10. STABILITY AND REACTIVITY 

Chemical stability : Stable under normal conditions. 

Possibility of hazardous 

reactions 

: Hazardous polymerisation does not occur. 

Conditions to avoid : Pressurized container. Protect from sunlight and do not 

expose to temperatures exceeding 50 °C. 

Decomposes under high temperature. 

Some risk may be expected of corrosive and toxic 
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decomposition products. 

Can form a combustible mixture with air at pressures above 

atmospheric pressure. 

Do not mix with oxygen or air above atmospheric pressure. 

Incompatible materials to 

avoid 

: Finely divided aluminium 

Potassium 

Calcium 

Powdered metals 

Aluminium 

Magnesium 

Zinc 

Hazardous decomposition 

products 

: Halogenated compounds 

Hydrogen fluoride 

Carbonyl halides 

Carbon oxides 

SECTION 11. TOXICOLOGICAL INFORMATION 

Acute inhalation toxicity : LC50: > 500000 ppm 

Exposure time: 4 h 

Species: rat 

Sensitisation : Cardiac sensitization 

Species: dogs 

Note: No-observed-effect level 50 000 ppm Lowest 

observable effect level 75 000 ppm 

Repeated dose toxicity : Species: rat 

NOEL: 40000 ppm 

Genotoxicity in vitro : Note: In vitro tests did not show mutagenic effects 

Further information : Note: Vapours are heavier than air and can cause suffocation 

by reducing oxygen available for breathing. Rapid evaporation 

of the liquid may cause frostbite. Avoid skin contact with 
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leaking liquid (danger of frostbite).

SECTION 12. ECOLOGICAL INFORMATION 

Further information on ecology 

Additional ecological 

information 

: Accumulation in aquatic organisms is unlikely. 

This product contains greenhouse gases which may 

contribute to global warming. Do NOT vent to the atmosphere. 

To comply with provisions of the U.S. Clean Air Act, any 

residual must be recovered. 

SECTION 13. DISPOSAL CONSIDERATIONS 

Disposal methods : Observe all Federal, State, and Local Environmental 

regulations. 

Note : This product is subject to U.S. Environmental Protection 

Agency Clean Air Act Regulations Section 608 in 40 CFR Part 

82 regarding refrigerant recycling.

SECTION 14. TRANSPORT INFORMATION 

DOT UN/ID No. : UN 3159

Proper shipping name : 1,1,1,2-Tetrafluoroethane 

Class 2.2 

Packing group 

Hazard Labels 2.2

IATA UN/ID No. : UN 3159 

Description of the goods : 1,1,1,2-Tetrafluoroethane 

Class : 2.2 

Hazard Labels : 2.2 

Packing instruction (cargo 

aircraft) 

: 200 

Packing instruction 

(passenger aircraft) 

: 200 
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IMDG UN/ID No. : UN 3159 

Description of the goods : 1,1,1,2-Tetrafluoroethane 

Class : 2.2 

Hazard Labels : 2.2 

EmS Number : F-C, S-V 

Marine pollutant : no 

SECTION 15. REGULATORY INFORMATION 

Inventories 

US. Toxic Substances 

Control Act 

: On TSCA Inventory 

Australia. Industrial 

Chemical (Notification and 

Assessment) Act 

: On the inventory, or in compliance with the inventory 

Canada. Canadian 

Environmental Protection 

Act (CEPA). Domestic 

Substances List (DSL) 

: All components of this product are on the Canadian DSL list. 

Japan. Kashin-Hou Law 

List 

: On the inventory, or in compliance with the inventory 

Korea. Existing Chemicals 

Inventory (KECI) 

: On the inventory, or in compliance with the inventory 

Philippines. The Toxic 

Substances and Hazardous 

and Nuclear Waste Control 

Act 

: On the inventory, or in compliance with the inventory 

China. Inventory of Existing 

Chemical Substances 

: On the inventory, or in compliance with the inventory 

NZIOC - New Zealand : On the inventory, or in compliance with the inventory 

National regulatory information 
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SARA 302 Components : SARA 302: No chemicals in this material are subject to the 

reporting requirements of SARA Title III, Section 302. 

SARA 313 Components : SARA 313: This material does not contain any chemical 

components with known CAS numbers that exceed the 

threshold (De Minimis) reporting levels established by SARA 

Title III, Section 313. 

SARA 311/312 Hazards : Acute Health Hazard 

Sudden Release of Pressure Hazard 

California Prop. 65 : This product does not contain any chemicals known to State of 

California to cause cancer, birth defects, or any other 

reproductive harm. 

New Jersey RTK : 1,1,1,2-Tetrafluoroethane 811-97-2 

Pennsylvania RTK : 1,1,1,2-Tetrafluoroethane 811-97-2 

WHMIS Classification : A: Compressed Gas 

This product has been classified according to the hazard criteria 

of the CPR and the MSDS contains all of the information 

required by the CPR.

Global warming potential : 1,300 

Ozone depletion potential 

(ODP) 

: 0 

SECTION 16. OTHER INFORMATION 

HMIS III NFPA

Health hazard : 1 2 

Flammability : 1 1 
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Physical Hazard : 0 

Instability : 0 

Hazard rating and rating systems (e.g. HMIS® III, NFPA): This information is intended solely for the 

use of individuals trained in the particular system. 

Further information 

The information provided in this Safety Data Sheet is correct to the best of our knowledge, 

information and belief at the date of its publication. The information given is designed only as a 

guidance for safe handling, use, processing, storage, transportation, disposal and release and is not 

to be considered a warranty or quality specification. The information relates only to the specific 

material designated and may not be valid for such material used in combination with any other 

materials or in any process, unless specified in the text. Final determination of suitability of any 

material is the sole responsibility of the user. This information should not constitute a guarantee for 

any specific product properties. 

Changes since the last version are highlighted in the margin. This version replaces all previous 

versions.

Previous Issue Date: 12/15/2009

Prepared by: Honeywell Performance Materials and Technologies Product Stewardship Group 
SAFETY DATA SHEET

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SECTION 1. PRODUCT AND COMPANY IDENTIFICATION 

Product name : Solstice® 1234ze 

MSDS Number : 000000012546 

Product Use Description : Aerosol propellant, Foam blowing agent

Manufacturer or supplier's 

details 

: Honeywell International, Inc. 

101 Columbia Road 

Morristown, NJ 07962-1057 

For more information call : 800-522-8001 

+1-973-455-6300 

 (Monday-Friday, 9:00am-5:00pm) 

In case of emergency call : Medical: 1-800-498-5701 or +1-303-389-1414 

: Transportation (CHEMTREC): 1-800-424-9300 or +1-703-

527-3887 

: 

 : (24 hours/day, 7 days/week) 

SECTION 2. HAZARDS IDENTIFICATION 

Emergency Overview 

Form : Liquefied gas 

Color : colourless 

Odor : slight ether-like 

Classification of the substance or mixture 

Classification of the 

substance or mixture 

: Gases under pressure, Liquefied gas 

Simple Asphyxiant 

GHS Label elements, including precautionary statements 
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Symbol(s) : 

Signal word : Warning 

Hazard statements : Contains gas under pressure; may explode if heated. 

May displace oxygen and cause rapid suffocation. 

Precautionary statements : Prevention: 

Use personal protective equipment as required. 

Storage: 

Protect from sunlight. Store in a well-ventilated place. 

Carcinogenicity 

No component of this product present at levels greater than or equal to 0.1% is identified as a known 

or anticipated carcinogen by NTP, IARC, or OSHA. 

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS 

Chemical nature : Substance 

Chemical Name CAS-No. Concentration 

trans-1,3,3,3-Tetrafluoroprop-1-ene 29118-24-9 100.00 %

SECTION 4. FIRST AID MEASURES 

Inhalation : Remove to fresh air. If breathing is irregular or stopped, 

administer artificial respiration. Use oxygen as required, 

provided a qualified operator is present. Call a physician. 

Skin contact : Rapid evapouration of the liquid may cause frostbite. If there is 

evidence of frostbite, bathe (do not rub) with lukewarm (not 

hot) water. If water is not available, cover with a clean, soft 

cloth or similar covering. Call a physician if irritation develops 
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or persists. 

Eye contact : Rinse immediately with plenty of water, also under the eyelids, 

for at least 15 minutes. In case of frostbite water should be 

lukewarm, not hot. If symptoms persist, call a physician. 

Ingestion : Unlikely route of exposure. As this product is a gas, refer to the 

inhalation section. Do not induce vomiting without medical 

advice. Call a physician immediately. 

Notes to physician 

Treatment : Treat frost-bitten areas as needed. 

SECTION 5. FIREFIGHTING MEASURES 

Suitable extinguishing media : Use extinguishing measures that are appropriate to local 

circumstances and the surrounding environment. 

Water mist 

Dry powder 

Foam 

Carbon dioxide (CO2) 

Unsuitable extinguishing 

media 

: High volume water jet 

Specific hazards during 

firefighting 

: Contents under pressure. 

Heating will cause pressure rise with risk of bursting 

Cool closed containers exposed to fire with water spray. 

Product is not combustible under normal conditions. 

However, this material can ignite when mixed with air under 

pressure and exposed to strong ignition sources. 

Do not allow run-off from fire fighting to enter drains or water 

courses. 

Vapours are heavier than air and can cause suffocation by 

reducing oxygen available for breathing. 

Some risk may be expected of corrosive and toxic 

decomposition products. 

Fire may cause evolution of: 

Hydrogen fluoride 

Special protective equipment 

for firefighters 

: In the event of fire and/or explosion do not breathe fumes. 

Wear self-contained breathing apparatus and protective suit. 

No unprotected exposed skin areas. 
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Exposure to decomposition products may be a hazard to 

health. 

SECTION 6. ACCIDENTAL RELEASE MEASURES 

Personal precautions : Immediately evacuate personnel to safe areas.

Keep people away from and upwind of spill/leak.

Wear personal protective equipment. Unprotected persons 

must be kept away.

Remove all sources of ignition.

Avoid skin contact with leaking liquid (danger of frostbite).

Ventilate the area.

After release, disperses into the air.

Vapours are heavier than air and can cause suffocation by 

reducing oxygen available for breathing.

Avoid accumulation of vapours in low areas.

Unprotected personnel should not return until air has been 

tested and determined safe.

Environmental precautions : Prevent further leakage or spillage if safe to do so.

The product evapourates readily.

Prevent spreading over a wide area (e.g. by containment or oil 

barriers).

Methods for cleaning up : Do not direct water spray at the point of leakage.

Allow to evapourate.

SECTION 7. HANDLING AND STORAGE 

Handling 

Handling : Handle with care.

Avoid inhalation of vapour or mist.

Do not get in eyes, on skin, or on clothing.

Wear personal protective equipment.

Pressurized container. Protect from sunlight and do not expose 

to temperatures exceeding 50 °C.

Follow all standard safety precautions for handling and use of 

compressed gas cylinders.

Use authorized cylinders only.
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Protect cylinders from physical damage.

Do not puncture or drop cylinders, expose them to open flame 

or excessive heat.

Do not pierce or burn, even after use. Do not spray on a naked 

flame or any incandescent material.

Do not remove screw cap until immediately ready for use.

Always replace cap after use.

Advice on protection 

against fire and explosion 

: Do not spray on a naked flame or any incandescent material.

Keep away from direct sunlight.

Fire or intense heat may cause violent rupture of packages.

Vapours may form explosive mixtures with air.

The product is not easily combustible.

Storage 

Requirements for storage 

areas and containers 

: Keep containers tightly closed in a cool, well-ventilated place.

Keep away from direct sunlight.

Protect cylinders from physical damage.

Store away from incompatible substances.

Further information on 

storage conditions 

: Keep only in the original container at temperature not 

exceeding 50°C

Advice on common storage : Do not store together with:

Oxidizing agents

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Protective measures : Do not breathe vapour.

Avoid contact with skin, eyes and clothing.

Ensure that eyewash stations and safety showers are close to 

the workstation location.

Engineering measures : Local exhaust

Eye protection : Goggles

Hand protection : Protective gloves
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Skin and body protection : impervious clothing

Wear cold insulating gloves/ face shield/ eye protection.

Respiratory protection : In case of insufficient ventilation wear suitable respiratory 

equipment.

Wear a positive-pressure supplied-air respirator.

Hygiene measures : Avoid breathing vapours, mist or gas.

Keep working clothes separately.

Do not smoke.

Exposure Guidelines

Components CAS-No. Value Control 

parameters 

Upda

te 

Basis 

trans-1,3,3,3-

Tetrafluoroprop1-ene 

29118-24-9 TWA :

time 

weighted 

average 

(800 ppm) 2012 WEEL:US. AIHA 

Workplace 

Environmental 

Exposure Level 

(WEEL) Guides

trans-1,3,3,3-

Tetrafluoroprop1-ene 

29118-24-9 TWA :

time 

weighted 

average 

(800 ppm) 31.03.

11

Honeywell:Limit 

established by 

Honeywell 

International Inc.

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES 

Physical state : Liquefied gas

Color : colourless 

Odor : slight ether-like 

pH : Note: neutral 

Boiling point/boiling range : -19 °C 

Flash point : Note: does not flash 
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Lower explosion limit : Note: Exhibits flame limits at temperatures in excess of 28 ̊ C. 

Upper explosion limit : Note: Exhibits flame limits at temperatures in excess of 28 ̊ C. 

Vapor pressure : 4,192 hPa 

at 20 °C(68 °F) 

 10,998 hPa 

at 54.4 °C(129.9 °F) 

Vapor density : 4 Note: (Air = 1.0) 

Density : 1.17 g/cm3 at 21.1 °C 

Water solubility : 0.373 g/l 

Partition coefficient: noctanol/water : log Pow: 1.6 

Ignition temperature : 368 °C 

Method: Auto-ignition temperature 

SECTION 10. STABILITY AND REACTIVITY 

Chemical stability : Stable under normal conditions. 

Possibility of hazardous 

reactions 

: Hazardous polymerisation does not occur. 

Conditions to avoid : Pressurized container. Protect from sunlight and do not 

expose to temperatures exceeding 50 °C. 

Can form a combustible mixture with air at pressures above 
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atmospheric pressure. 

Do not mix with oxygen or air above atmospheric pressure. 

Incompatible materials to 

avoid 

: Reactions with alkali metals. 

Hazardous decomposition 

products 

: Pyrolysis products containing fluoride 

Fluorocarbons 

Hydrogen fluoride 

SECTION 11. TOXICOLOGICAL INFORMATION 

Acute inhalation toxicity : Species: mouse 

Note: Acute (4-Hour) Inhalation Toxicity Screening Study 

(mouse): No lethality at >100,000 ppm. 

 : LC50: > 207000 ppm 

Exposure time: 4 h 

Species: rat 

Skin irritation : Species: rabbit 

Result: No skin irritation 

Method: OECD Test Guideline 404 

Sensitisation : Cardiac sensitization 

Species: dogs 

Result: Did not cause sensitisation on laboratory animals. 

Repeated dose toxicity : Species: rat 

Application Route: Inhalation 

Exposure time: 13 Weeks 

Note: Causes mild effects on the heart. NOEL 5,000 ppm 

Genotoxicity in vitro : Test Method: Chromosome aberration test in vitro 

Cell type: Human lymphocytes 

Result: negative 

 : Test Method: Ames test 

Result: negative 
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Genotoxicity in vivo : Test Method: Mutagenicity (in vivo mammalian bone-marrow 

cytogenetic test, chromosomal analysis) 

Species: mouse 

Cell type: Micronucleus 

Application Route: Inhalation 

Result: negative 

Teratogenicity : Species: rabbit 

Method: Prenatal Developmental Inhalation Toxicity Study 

Note: Did not show teratogenic effects in animal experiments. 

 : Species: rat 

Method: Prenatal Developmental Inhalation Toxicity Study 

Note: Did not show teratogenic effects in animal experiments. 

Further information : Note: Excessive exposure may cause central nervous system 

effects including drowsiness and dizziness. Excessive 

exposure may also cause cardiac arrhythmia. Rapid 

evapouration of the liquid may cause frostbite.

SECTION 12. ECOLOGICAL INFORMATION 

Ecotoxicity effects 

Toxicity to fish : NOEC: > 117 mg/l 

Exposure time: 96 h 

Species: Cyprinus carpio (Carp) 

Toxicity to daphnia and other 

aquatic invertebrates

: EC50: > 160 mg/l 

Exposure time: 48 h 

Species: Daphnia magna (Water flea) 

Toxicity to algae : Growth inhibition 

NOEC: > 170 mg/l 

Exposure time: 72 h 

Species: Algae 
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Elimination information (persistence and degradability) 

Biodegradability : aerobic 

Result: Not readily biodegradable. 

Further information on ecology 

Additional ecological 

information 

: no data available 

SECTION 13. DISPOSAL CONSIDERATIONS 

Disposal methods : Observe all Federal, State, and Local Environmental 

regulations. 

SECTION 14. TRANSPORT INFORMATION 

DOT UN/ID No. : UN 3163

Proper shipping name : LIQUEFIED GAS, N.O.S. 

(trans-1,3,3,3-Tetrafluoroprop-1-ene) 

Class 2.2 

Packing group 

Hazard Labels 2.2

IATA UN/ID No. : UN 3163 

Description of the goods : LIQUEFIED GAS, N.O.S. 

 (trans-1,3,3,3-Tetrafluoroprop-1-ene) 

Class : 2.2 

Hazard Labels : 2.2 

Packing instruction (cargo 

aircraft) 

: 200 

Packing instruction 

(passenger aircraft) 

: 200 

IMDG UN/ID No. : UN 3163 

Description of the goods : LIQUEFIED GAS, N.O.S. 

 (TRANS-1,3,3,3-TETRAFLUOROPROP-1-ENE) 

Class : 2.2 

Hazard Labels : 2.2 
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EmS Number : F-C, S-V 

Marine pollutant : no 

SECTION 15. REGULATORY INFORMATION 

Inventories 

US. Toxic Substances 

Control Act 

: On TSCA Inventory 

Australia. Industrial 

Chemical (Notification and 

Assessment) Act 

: Not in compliance with the inventory 

: trans-1,3,3,3-Tetrafluoroprop-1-

ene 

29118-24-9 

Canada. Canadian 

Environmental Protection 

Act (CEPA). Domestic 

Substances List (DSL) 

: All components of this product are on the Canadian DSL. 

Japan. Kashin-Hou Law 

List 

: On the inventory, or in compliance with the inventory 

Korea. Toxic Chemical 

Control Law (TCCL) List 

: Not in compliance with the inventory 

: trans-1,3,3,3-Tetrafluoroprop-1-

ene 

29118-24-9 

Philippines. The Toxic 

Substances and Hazardous 

and Nuclear Waste Control 

Act 

: Not in compliance with the inventory 

: trans-1,3,3,3-Tetrafluoroprop-1-

ene 

29118-24-9 

China. Inventory of Existing 

Chemical Substances 

: On the inventory, or in compliance with the inventory 

New Zealand. Inventory of 

Chemicals (NZIoC), as 

published by ERMA New 

Zealand 

: Not in compliance with the inventory 
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: trans-1,3,3,3-Tetrafluoroprop-1-

ene 

29118-24-9 

National regulatory information 

SARA 302 Components : SARA 302: No chemicals in this material are subject to the 

reporting requirements of SARA Title III, Section 302. 

SARA 313 Components : SARA 313: This material does not contain any chemical 

components with known CAS numbers that exceed the 

threshold (De Minimis) reporting levels established by SARA 

Title III, Section 313. 

SARA 311/312 Hazards : Acute Health Hazard 

Sudden Release of Pressure Hazard 

California Prop. 65 : This product does not contain any chemicals known to State of 

California to cause cancer, birth defects, or any other 

reproductive harm. 

WHMIS Classification : A: Compressed Gas 

This product has been classified according to the hazard criteria 

of the CPR and the MSDS contains all of the information 

required by the CPR.

SECTION 16. OTHER INFORMATION 

HMIS III NFPA

Health hazard : 1 2 

Flammability : 0 0 

Physical Hazard : 0 

Instability : 0 
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Hazard rating and rating systems (e.g. HMIS® III, NFPA): This information is intended solely for the 

use of individuals trained in the particular system. 

Further information 

The information provided in this Safety Data Sheet is correct to the best of our knowledge, 

information and belief at the date of its publication. The information given is designed only as a 

guidance for safe handling, use, processing, storage, transportation, disposal and release and is not 

to be considered a warranty or quality specification. The information relates only to the specific 

material designated and may not be valid for such material used in combination with any other 

materials or in any process, unless specified in the text. Final determination of suitability of any 

material is the sole responsibility of the user. This information should not constitute a guarantee for 

any specific product properties. 

Changes since the last version are highlighted in the margin. This version replaces all previous 

versions.

Previous Issue Date: 01/24/2014

Prepared by Honeywell Performance Materials and Technologies Product Stewardship Group 
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SECTION 1. PRODUCT AND COMPANY IDENTIFICATION 

Product name : Solstice® N-40 

MSDS Number : 000000017419 

Product Use Description : Refrigerant

Manufacturer or supplier's 

details 

: Honeywell International, Inc. 

101 Columbia Road 

Morristown, NJ 07962-1057 

For more information call : 800-522-8001 

+1-973-455-6300 

 (Monday-Friday, 9:00am-5:00pm) 

In case of emergency call : Medical: 1-800-498-5701 or +1-303-389-1414 

: Transportation (CHEMTREC): 1-800-424-9300 or +1-703-

527-3887 

: 

 : (24 hours/day, 7 days/week) 

SECTION 2. HAZARDS IDENTIFICATION 

Emergency Overview 

Form : Liquefied gas 

Color : clear colourless 

Odor : slight ether-like 

Classification of the substance or mixture 

Classification of the 

substance or mixture 

: Gases under pressure, Liquefied gas 

Simple Asphyxiant 

GHS Label elements, including precautionary statements 
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Symbol(s) : 

Signal word : Warning 

Hazard statements : Contains gas under pressure; may explode if heated. 

May displace oxygen and cause rapid suffocation. 

Precautionary statements : Prevention: 

Use personal protective equipment as required. 

Storage: 

Protect from sunlight. Store in a well-ventilated place. 

Hazards not otherwise 

classified 

: May cause frostbite. 

May cause cardiac arrhythmia. 

May cause eye and skin irritation. 

Carcinogenicity 

No component of this product present at levels greater than or equal to 0.1% is identified as a known 

or anticipated carcinogen by NTP, IARC, or OSHA. 

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS 

Chemical nature : Mixture 

Chemical Name CAS-No. Concentration 

Difluoromethane 75-10-5 26.00 %

Pentafluoroethane 354-33-6 26.00 %

1,1,1,2-Tetrafluoroethane 811-97-2 21.00 %
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2,3,3,3-Tetrafluoroprop-1-ene 754-12-1 20.00 %

trans-1,3,3,3-Tetrafluoroprop-1-ene 29118-24-9 7.00 %

SECTION 4. FIRST AID MEASURES 

Inhalation : Move to fresh air. If breathing is irregular or stopped, 

administer artificial respiration. Use oxygen as required, 

provided a qualified operator is present. Call a physician. Do 

not give drugs from adrenaline-ephedrine group. 

Skin contact : After contact with skin, wash immediately with plenty of water. 

If there is evidence of frostbite, bathe (do not rub) with 

lukewarm (not hot) water. If water is not available, cover with a 

clean, soft cloth or similar covering. If symptoms persist, call a 

physician. 

Eye contact : Rinse immediately with plenty of water, also under the eyelids, 

for at least 15 minutes. In case of frostbite water should be 

lukewarm, not hot. If symptoms persist, call a physician. 

Ingestion : Unlikely route of exposure. As this product is a gas, refer to the 

inhalation section. Do not induce vomiting without medical 

advice. Call a physician immediately. 

Notes to physician 

Treatment : Because of the possible disturbances of cardiac rhythm, 

catecholamine drugs, such as epinephrine, should be used 

with special caution and only in situations of emergency life 

support. Treatment of overexposure should be directed at the 

control of symptoms and the clinical conditions. Treat frostbitten areas as needed. 

SECTION 5. FIREFIGHTING MEASURES 

Suitable extinguishing media : The product is not flammable. 

Use water spray, alcohol-resistant foam, dry chemical or 

carbon dioxide. 

Use extinguishing measures that are appropriate to local 
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circumstances and the surrounding environment. 

Specific hazards during 

firefighting 

: Contents under pressure. 

This product is not flammable at ambient temperatures and 

atmospheric pressure. 

However, this material can ignite when mixed with air under 

pressure and exposed to strong ignition sources. 

Container may rupture on heating. 

Cool closed containers exposed to fire with water spray. 

Do not allow run-off from fire fighting to enter drains or water 

courses. 

Vapours are heavier than air and can cause suffocation by 

reducing oxygen available for breathing. 

In case of fire hazardous decomposition products may be 

produced such as: 

Hydrogen halides 

Hydrogen fluoride 

Carbon monoxide 

Carbon dioxide (CO2) 

Carbonyl halides 

Special protective equipment 

for firefighters 

: In the event of fire and/or explosion do not breathe fumes. 

Wear self-contained breathing apparatus and protective suit. 

No unprotected exposed skin areas. 

SECTION 6. ACCIDENTAL RELEASE MEASURES 

Personal precautions : Immediately evacuate personnel to safe areas.

Keep people away from and upwind of spill/leak.

Wear personal protective equipment. Unprotected persons 

must be kept away.

Remove all sources of ignition.

Avoid skin contact with leaking liquid (danger of frostbite).

Ventilate the area.

After release, disperses into the air.

Vapours are heavier than air and can cause suffocation by 

reducing oxygen available for breathing.

Avoid accumulation of vapours in low areas.

Unprotected personnel should not return until air has been 

tested and determined safe.

Ensure that the oxygen content is >= 19.5%.
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Environmental precautions : Prevent further leakage or spillage if safe to do so.

The product evapourates readily.

Methods for cleaning up : Ventilate the area.

SECTION 7. HANDLING AND STORAGE 

Handling 

Handling : Handle with care.

Avoid inhalation of vapour or mist.

Do not get in eyes, on skin, or on clothing.

Wear personal protective equipment.

Use only in well-ventilated areas.

Pressurized container. Protect from sunlight and do not expose 

to temperatures exceeding 50 °C.

Follow all standard safety precautions for handling and use of 

compressed gas cylinders.

Use authorized cylinders only.

Protect cylinders from physical damage.

Do not puncture or drop cylinders, expose them to open flame 

or excessive heat.

Do not pierce or burn, even after use. Do not spray on a naked 

flame or any incandescent material.

Do not remove screw cap until immediately ready for use.

Always replace cap after use.

Advice on protection 

against fire and explosion 

: The product is not flammable.

Can form a combustible mixture with air at pressures above 

atmospheric pressure.

Storage 

Requirements for storage 

areas and containers 

: Pressurized container: protect from sunlight and do not expose 

to temperatures exceeding 50 °C. Do not pierce or burn, even 

after use.

Keep containers tightly closed in a dry, cool and well-ventilated 

place.

Storage rooms must be properly ventilated.

Ensure adequate ventilation, especially in confined areas.

Protect cylinders from physical damage.
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SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Protective measures : Do not breathe vapour.

Avoid contact with skin, eyes and clothing.

Ensure that eyewash stations and safety showers are close to 

the workstation location.

Engineering measures : General room ventilation is adequate for storage and handling.

Perform filling operations only at stations with exhaust 

ventilation facilities.

Eye protection : Wear as appropriate:

Safety glasses with side-shields

If splashes are likely to occur, wear:

Goggles or face shield, giving complete protection to eyes

Hand protection : Leather gloves

In case of contact through splashing:

Protective gloves

Neoprene gloves

Polyvinyl alcohol or nitrile- butyl-rubber gloves

Skin and body protection : Avoid skin contact with leaking liquid (danger of frostbite).

Wear cold insulating gloves/ face shield/ eye protection.

Respiratory protection : In case of insufficient ventilation, wear suitable respiratory 

equipment.

Wear a positive-pressure supplied-air respirator.

Vapours are heavier than air and can cause suffocation by 

reducing oxygen available for breathing.

For rescue and maintenance work in storage tanks use selfcontained breathing apparatus.

Hygiene measures : Handle in accordance with good industrial hygiene and safety 

practice.

Ensure adequate ventilation, especially in confined areas.

Avoid contact with skin, eyes and clothing.

Remove and wash contaminated clothing before re-use.

Keep working clothes separately.

Exposure Guidelines

Components CAS-No. Value Control 

parameters 

Upda

te 

Basis 
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Difluoromethane 75-10-5 TWA :

time 

weighted 

average 

2,200 mg/m3 

(1,000 ppm) 

2007 WEEL:US. AIHA 

Workplace 

Environmental 

Exposure Level 

(WEEL) Guides

Difluoromethane 75-10-5 TWA :

time 

weighted 

average 

(1,000 ppm) 1994 Honeywell:Limit 

established by 

Honeywell 

International Inc.

Pentafluoroethan

e 

354-33-6 TWA :

time 

weighted 

average 

4,900 mg/m3 

(1,000 ppm) 

2007 WEEL:US. AIHA 

Workplace 

Environmental 

Exposure Level 

(WEEL) Guides

Pentafluoroethan

e 

354-33-6 TWA :

time 

weighted 

average 

(1,000 ppm) Honeywell:Limit 

established by 

Honeywell 

International Inc.

1,1,1,2-

Tetrafluoroethane 

811-97-2 TWA :

time 

weighted 

average 

(1,000 ppm) Honeywell:Limit 

established by 

Honeywell 

International Inc.

1,1,1,2-

Tetrafluoroethane 

811-97-2 TWA :

time 

weighted 

average 

4,240 mg/m3 

(1,000 ppm) 

2007 WEEL:US. AIHA 

Workplace 

Environmental 

Exposure Level 

(WEEL) Guides
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2,3,3,3-

Tetrafluoroprop1-ene 

754-12-1 TWA :

time 

weighted 

average 

(500 ppm) 2009 WEEL:US. AIHA 

Workplace 

Environmental 

Exposure Level 

(WEEL) Guides

2,3,3,3-

Tetrafluoroprop1-ene 

754-12-1 TWA :

time 

weighted 

average 

(500 ppm) 03 15 

2010

Honeywell:Limit 

established by 

Honeywell 

International Inc.

2,3,3,3-

Tetrafluoroprop1-ene 

754-12-1 STEL :

Short 

term 

exposure 

limit 

(1,500 ppm) 03 15 

2010

Honeywell:Limit 

established by 

Honeywell 

International Inc.

trans-1,3,3,3-

Tetrafluoroprop1-ene 

29118-24-9 TWA :

time 

weighted 

average 

(800 ppm) 2012 WEEL:US. AIHA 

Workplace 

Environmental 

Exposure Level 

(WEEL) Guides

trans-1,3,3,3-

Tetrafluoroprop1-ene 

29118-24-9 TWA :

time 

weighted 

average 

(800 ppm) 31.03.

11

Honeywell:Limit 

established by 

Honeywell 

International Inc.

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES 

Physical state : Liquefied gas

Color : clear colourless 

Odor : slight ether-like 

pH : Note: neutral 
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Melting point/freezing point : Note: no data available 

Boiling point/boiling range : Note: no data available 

Flash point : Note: not applicable 

Lower explosion limit : Note: None 

Upper explosion limit : Note: None 

Vapor pressure : 1,120 kPa 

at 21.1 °C(70.0 °F) 

 2,588 kPa 

at 54.4 °C(129.9 °F) 

Vapor density : Note: no data available 

Density : Note: no data available 

Water solubility : Note: no data available 

Partition coefficient: noctanol/water : Note: no data available 

Ignition temperature : Note: no data available 

Decomposition temperature : > 250 °C 

Note: To avoid thermal decomposition, do not overheat. 
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SECTION 10. STABILITY AND REACTIVITY 

Chemical stability : Stable under normal conditions. 

Possibility of hazardous 

reactions 

: Hazardous polymerisation does not occur. 

Conditions to avoid : Pressurized container. Protect from sunlight and do not 

expose to temperatures exceeding 50 °C. 

Decomposes under high temperature. 

Some risk may be expected of corrosive and toxic 

decomposition products. 

Can form a combustible mixture with air at pressures above 

atmospheric pressure. 

Do not mix with oxygen or air above atmospheric pressure. 

Incompatible materials to 

avoid 

: Finely divided aluminium 

Potassium 

Calcium 

Powdered metals 

Aluminium 

Magnesium 

Zinc 

Hazardous decomposition 

products 

: Halogenated compounds 

Hydrogen fluoride 

Carbonyl halides 

Carbon oxides 

SECTION 11. TOXICOLOGICAL INFORMATION 

Acute inhalation toxicity

Difluoromethane : LC50: > 520000 ppm 

Exposure time: 4 h 

Species: rat 

Pentafluoroethane : > 769000 ppm 

Exposure time: 4 h 

Species: rat 

1,1,1,2-Tetrafluoroethane : LC50: > 500000 ppm 
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Exposure time: 4 h 

Species: rat 

2,3,3,3-Tetrafluoroprop-1-

ene 

: LC50: > 400000 ppm 

Exposure time: 4 h 

Species: rat 

trans-1,3,3,3-

Tetrafluoroprop-1-ene 

: 100000 ppm 

Species: mouse 

Note: Acute (4-Hour) Inhalation Toxicity Screening Study 

(mouse): No lethality at >100,000 ppm. 

 LC50: > 207000 ppm 

Exposure time: 4 h 

Species: rat 

Skin irritation

trans-1,3,3,3-

Tetrafluoroprop-1-ene 

: Species: rabbit 

Result: No skin irritation 

Method: OECD Test Guideline 404 

Sensitisation

Difluoromethane : Cardiac sensitization 

Species: dogs 

Note: No-observed-effect level 

>350 000 ppm 

Pentafluoroethane : Cardiac sensitization 

Species: dogs 

Note: No-observed-effect level 

75 000 ppm 

Lowest observable effect level 

100 000 ppm 

1,1,1,2-Tetrafluoroethane : Cardiac sensitization 

Species: dogs 

Note: No-observed-effect level 

50 000 ppm 

Lowest observable effect level 

75 000 ppm 

2,3,3,3-Tetrafluoroprop-1-

ene 

: Cardiac sensitization 

Species: dogs 
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Result: No effects observed for exposures up to 12% (120,189 

ppm). 

trans-1,3,3,3-

Tetrafluoroprop-1-ene 

: Cardiac sensitization 

Species: dogs 

Note: Did not cause sensitisation on laboratory animals. 

Repeated dose toxicity

Difluoromethane : Species: rat 

Application Route: Inhalation 

Exposure time: (90 d) 

NOEL: 50000 ppm 

Subchronic toxicity 

Pentafluoroethane : Species: rat 

Application Route: Inhalation 

Exposure time: (4 Weeks) 

NOEL: 50000 ppm 

Subchronic toxicity 

1,1,1,2-Tetrafluoroethane : Species: rat 

NOEL: 40000 ppm 

2,3,3,3-Tetrafluoroprop-1-

ene 

: Species: rat 

Application Route: Inhalation 

Exposure time: (2 Weeks) 

NOEL: 50000 ppm 

 Species: rat 

Application Route: Inhalation 

Exposure time: (4 Weeks) 

NOAEL (No observed adverse effect level): 50000 ppm 

 Species: rat 

Application Route: Inhalation 

Exposure time: (13 Weeks) 

NOAEL (No observed adverse effect level): 50000 ppm 

 Species: rabbit, male 

Application Route: Inhalation 

Exposure time: (28 d) 

No-observed-effect level: 500 ppm 

 Species: rabbit, female 
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Application Route: Inhalation 

Exposure time: (28 d) 

No-observed-effect level: 1000 ppm 

 Species: mini-pig 

Application Route: Inhalation 

Exposure time: (28 d) 

NOAEL (No observed adverse effect level): 10,000 ppm 

(highest exposure tested). 

trans-1,3,3,3-

Tetrafluoroprop-1-ene 

: Species: rat 

Application Route: Inhalation 

Exposure time: (13 Weeks) 

NOEL: 5000 ppm 

Causes mild effects on the heart. 

Genotoxicity in vitro

Difluoromethane : Test Method: Ames test 

Result: negative 

Pentafluoroethane : Test Method: Ames test 

Result: negative 

1,1,1,2-Tetrafluoroethane : Note: In vitro tests did not show mutagenic effects 

2,3,3,3-Tetrafluoroprop-1-

ene 

: Test Method: Ames test 

Result: 20% and higher, positive in TA 100 and e. coli WP2 

uvrA, negative in TA98, TA100, and TA1535. 

trans-1,3,3,3-

Tetrafluoroprop-1-ene 

: Test Method: Chromosome aberration test in vitro 

Cell type: Human lymphocytes 

Result: negative 

 : Cell type: Human lymphocytes 

Result: negative 

Method: Mutagenicity (in vitro mammalian cytogenetic test) 

 : Test Method: Chromosome aberration test in vitro 

Result: negative 

 : Cell type: Human lymphocytes 

Result: negative 

 : Cell type: Chinese Hamster Ovary Cells 
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Result: negative 

 : Test Method: Chromosome aberration test in vitro 

Cell type: Human lymphocytes 

Result: negative 

Note: Dose 760,000 ppm 

 : Test Method: Chromosome aberration test in vitro 

Cell type: Chinese Hamster Lung Cells 

Result: negative 

 : Test Method: Ames test 

Result: negative 

Genotoxicity in vivo

Difluoromethane : Species: mouse 

Cell type: Bone marrow 

Method: Mutagenicity (micronucleus test) 

Result: negative 

2,3,3,3-Tetrafluoroprop-1-

ene 

: Species: mouse 

Cell type: Micronucleus 

Dose: up to 200,000 ppm (4 hour) 

Result: negative 

 : Test Method: Unscheduled DNA synthesis 

Dose: up to 50,000 ppm (4 weeks) 

Result: negative 

 : Species: rat 

Cell type: Micronucleus 

Dose: up to 50,000 ppm (4 weeks) 

Result: negative 

trans-1,3,3,3-

Tetrafluoroprop-1-ene 

: Test Method: Mutagenicity (in vivo mammalian bone-marrow 

cytogenetic test, chromosomal analysis) 

Species: mouse 

Cell type: Micronucleus 

Application Route: Inhalation 

Result: negative 

Reproductive toxicity 

2,3,3,3-Tetrafluoroprop-1- : Species: rat 
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ene Application Route: Inhalation exposure 

Exposure time: Two-generation reproductive toxicity 

NOAEL,parent: 50,000 ppm 

NOAEL,F1: 50,000 ppm 

NOAEL,F2: 50,000 ppm 

Teratogenicity

Difluoromethane : Species: rat 

Dose: NOEL - 50,000 ppm 

Note: Did not show teratogenic effects in animal experiments. 

 Species: rabbit 

Dose: NOEL - 50,000 ppm 

Note: Did not show teratogenic effects in animal experiments. 

Pentafluoroethane : Species: rabbit 

Application Route: Inhalation exposure 

NOAEL,Teratog: 50,000 ppm 

NOAEL,Maternal: 50,000 ppm 

Note: Did not show teratogenic effects in animal experiments. 

 Species: rat 

Application Route: Inhalation exposure 

NOAEL,Teratog: 50,000 ppm 

NOAEL,Maternal: 50,000 ppm 

Note: Did not show teratogenic effects in animal experiments. 

2,3,3,3-Tetrafluoroprop-1-

ene 

: Species: rat 

Dose: NOAEL (No observed adverse effect level) - 50,000 

ppm 

 Species: rabbit 

Dose: NOAEL (No observed adverse effect level) - 4,000 ppm 

trans-1,3,3,3-

Tetrafluoroprop-1-ene 

: Species: rabbit 

Method: Prenatal Developmental Inhalation Toxicity Study 

Note: Did not show teratogenic effects in animal experiments. 

 Species: rat 

Method: Prenatal Developmental Inhalation Toxicity Study 

Note: Did not show teratogenic effects in animal experiments. 
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Further information 

1,1,1,2-Tetrafluoroethane : Note: 

Vapours are heavier than air and can cause suffocation by 

reducing oxygen available for breathing. 

Rapid evapouration of the liquid may cause frostbite. 

Avoid skin contact with leaking liquid (danger of frostbite). 

SECTION 12. ECOLOGICAL INFORMATION 

Toxicity to fish 

2,3,3,3-Tetrafluoroprop-1-

ene 

: LC50: > 197 mg/l 

Exposure time: 96 h 

Species: Cyprinus carpio (Carp) 

Method: OECD Test Guideline 203 

Note: No demonstrable toxic effect in saturated solution. 

trans-1,3,3,3-

Tetrafluoroprop-1-ene 

: NOEC: > 117 mg/l 

Exposure time: 96 h 

Species: Cyprinus carpio (Carp) 

Toxicity to daphnia and other aquatic invertebrates 

2,3,3,3-Tetrafluoroprop-1-

ene 

: EC50: > 83 mg/l 

Exposure time: 48 h 

Species: Daphnia magna (Water flea) 

Method: OECD Test Guideline 202 

trans-1,3,3,3-

Tetrafluoroprop-1-ene 

: EC50: > 160 mg/l 

Exposure time: 48 h 

Species: Daphnia magna (Water flea) 

Toxicity to algae 

2,3,3,3-Tetrafluoroprop-1-

ene 

: EC50: > 100 mg/l 

Species: Scenedesmus capricornutum (fresh water algae) 

trans-1,3,3,3-

Tetrafluoroprop-1-ene 

: Growth inhibition 

NOEC: > 170 mg/l 

Exposure time: 72 h 

Species: Algae 
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Biodegradability 

Difluoromethane : Note: Minimal 

Pentafluoroethane : Result: Not readily biodegradable. 

Value: 5 % 

Method: OECD 301 D 

2,3,3,3-Tetrafluoroprop-1-

ene 

: Result: Not readily biodegradable. 

trans-1,3,3,3-

Tetrafluoroprop-1-ene 

: aerobic 

Result: Not readily biodegradable. 

Further information on ecology 

Additional ecological 

information 

: This product is subject to U.S. Environmental Protection 

Agency Clean Air Act Regulations at 40 CFR Part 82. 

This product contains greenhouse gases which may 

contribute to global warming. Do NOT vent to the atmosphere. 

To comply with provisions of the U.S. Clean Air Act, any 

residual must be recovered. 

SECTION 13. DISPOSAL CONSIDERATIONS 

Disposal methods : Observe all Federal, State, and Local Environmental 

regulations. 

SECTION 14. TRANSPORT INFORMATION 

DOT UN/ID No. : UN 3163

Proper shipping name : LIQUEFIED GAS, N.O.S. 

(Pentafluoroethane, Difluoromethane, 1,1,1,2-

Tetrafluoroethane) 

Class 2.2 

Packing group 

Hazard Labels 2.2

IATA UN/ID No. : UN 3163 

Description of the goods : LIQUEFIED GAS, N.O.S. 

 (Pentafluoroethane, Difluoromethane, 1,1,1,2-
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Tetrafluoroethane) 

Class : 2.2 

Hazard Labels : 2.2 

Packing instruction (cargo 

aircraft) 

: 200 

Packing instruction 

(passenger aircraft) 

: 200 

IMDG UN/ID No. : UN 3163 

Description of the goods : LIQUEFIED GAS, N.O.S. 

 (PENTAFLUOROETHANE, 

DIFLUOROMETHANE, 1,1,1,2-

TETRAFLUOROETHANE) 

Class : 2.2 

Hazard Labels : 2.2 

EmS Number : F-C, S-V 

Marine pollutant : no 

SECTION 15. REGULATORY INFORMATION 

Inventories 

US. Toxic Substances 

Control Act 

: On TSCA Inventory 

Australia. Industrial 

Chemical (Notification and 

Assessment) Act 

: Not in compliance with the inventory 

Canada. Canadian 

Environmental Protection 

Act (CEPA). Domestic 

Substances List (DSL) 

: All components of this product are on the Canadian DSL. 

Japan. Kashin-Hou Law 

List 

: On the inventory, or in compliance with the inventory 

Korea. Toxic Chemical 

Control Law (TCCL) List 

: On the inventory, or in compliance with the inventory 

Philippines. The Toxic 

Substances and Hazardous 

and Nuclear Waste Control 

Act 

: Not in compliance with the inventory 
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China. Inventory of Existing 

Chemical Substances 

: Not in compliance with the inventory 

New Zealand. Inventory of 

Chemicals (NZIoC), as 

published by ERMA New 

Zealand 

: Not in compliance with the inventory 

TSCA 12B : US. Toxic Substances Control Act (TSCA) Section 12(b) Export 

Notification (40 CFR 707, Subpt D) 

 2,3,3,3-Tetrafluoroprop-1-ene 754-12-1 

National regulatory information 

SARA 302 Components : SARA 302: No chemicals in this material are subject to the 

reporting requirements of SARA Title III, Section 302. 

SARA 313 Components : SARA 313: This material does not contain any chemical 

components with known CAS numbers that exceed the 

threshold (De Minimis) reporting levels established by SARA 

Title III, Section 313. 

SARA 311/312 Hazards : Sudden Release of Pressure Hazard 

Acute Health Hazard 

California Prop. 65 : WARNING! This product contains a chemical known to the 

State of California to cause cancer. 

Dichloromethane 75-09-2 
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: WARNING: This product contains a chemical known to the 

State of California to cause birth defects or other reproductive 

harm. 

Chloromethane 74-87-3 

Massachusetts RTK : Dichloromethane 75-09-2 

Pennsylvania RTK : Difluoromethane 75-10-5 

WHMIS Classification : A: Compressed Gas 

This product has been classified according to the hazard criteria 

of the CPR and the MSDS contains all of the information 

required by the CPR.

SECTION 16. OTHER INFORMATION 

HMIS III NFPA

Health hazard : 1 2 

Flammability : 1 1 

Physical Hazard : 0 

Instability : 0 

Hazard rating and rating systems (e.g. HMIS® III, NFPA): This information is intended solely for the 

use of individuals trained in the particular system. 

Further information 

The information provided in this Safety Data Sheet is correct to the best of our knowledge, 

information and belief at the date of its publication. The information given is designed only as a 

guidance for safe handling, use, processing, storage, transportation, disposal and release and is not 

to be considered a warranty or quality specification. The information relates only to the specific 

material designated and may not be valid for such material used in combination with any other 

materials or in any process, unless specified in the text. Final determination of suitability of any 

material is the sole responsibility of the user. This information should not constitute a guarantee for 

any specific product properties. 
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Changes since the last version are highlighted in the margin. This version replaces all previous 

versions.

Previous Issue Date: 09/04/2013

Prepared by Honeywell Performance Materials and Technologies Product Stewardship Group 
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SECTION 1. PRODUCT AND COMPANY IDENTIFICATION 

Product name : Solstice® yf Refrigerant (R-1234yf) 

MSDS Number : 000000011078 

Product Use Description : Refrigerant

Manufacturer or supplier's 

details 

: Honeywell International, Inc. 

101 Columbia Road 

Morristown, NJ 07962-1057 

For more information call : 800-522-8001 

+1-973-455-6300 

 (Monday-Friday, 9:00am-5:00pm) 

In case of emergency call : Medical: 1-800-498-5701 or +1-303-389-1414 

: Transportation (CHEMTREC): 1-800-424-9300 or +1-703-

527-3887 

: 

 : (24 hours/day, 7 days/week) 

SECTION 2. HAZARDS IDENTIFICATION 

Emergency Overview 

Form : Liquefied gas 

Color : clear 

Odor : slight 

Classification of the substance or mixture 

Classification of the 

substance or mixture 

: Flammable gases, Category 1 

Gases under pressure, Liquefied gas 

Simple Asphyxiant 
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GHS Label elements, including precautionary statements 

Symbol(s) : 

Signal word : Danger 

Hazard statements : Extremely flammable gas. 

Contains gas under pressure; may explode if heated. 

May displace oxygen and cause rapid suffocation. 

Precautionary statements : Prevention: 

Keep away from heat/sparks/open flames/hot surfaces. - No 

smoking. 

Response: 

Leaking gas fire: Do not extinguish, unless leak can be stopped 

safely. 

Eliminate all ignition sources if safe to do so. 

Storage: 

Protect from sunlight. Store in a well-ventilated place. 

Hazards not otherwise 

classified 

: May cause eye and skin irritation. 

May cause frostbite. 

Carcinogenicity 

No component of this product present at levels greater than or equal to 0.1% is identified as a known 

or anticipated carcinogen by NTP, IARC, or OSHA. 

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS 

Chemical nature : Substance 

Chemical Name CAS-No. Concentration 

2,3,3,3-Tetrafluoroprop-1-ene 754-12-1 100.00 %
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SECTION 4. FIRST AID MEASURES 

General advice : First aider needs to protect himself. Take off all contaminated 

clothing immediately. 

Inhalation : Remove to fresh air. If not breathing, give artificial respiration. 

If breathing is difficult, give oxygen. Use oxygen as required, 

provided a qualified operator is present. Call a physician. 

Skin contact : After contact with skin, wash immediately with plenty of water. 

Rapid evapouration of the liquid may cause frostbite. If there is 

evidence of frostbite, bathe (do not rub) with lukewarm (not 

hot) water. If water is not available, cover with a clean, soft 

cloth or similar covering. Call a physician. Wash contaminated 

clothing before re-use. 

Eye contact : Rinse immediately with plenty of water, also under the eyelids, 

for at least 15 minutes. In case of frostbite water should be 

lukewarm, not hot. Call a physician. 

Ingestion : Unlikely route of exposure. As this product is a gas, refer to the 

inhalation section. Do not induce vomiting without medical 

advice. If conscious, drink plenty of water. Never give anything 

by mouth to an unconscious person. Call a physician 

immediately. 

Notes to physician 

Treatment : Treat frost-bitten areas as needed. Treat symptomatically. 

SECTION 5. FIREFIGHTING MEASURES 

Suitable extinguishing media : In case of fire, allow gas to burn if flow cannot be shut off 

immediately. 

Apply water from a safe distance to cool container and protect 

surrounding area. 

Use water spray, alcohol-resistant foam, dry chemical or 

carbon dioxide. 

Specific hazards during 

firefighting 

: Flammable gas. 

Contents under pressure. 
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Vapours are heavier than air and can cause suffocation by 

reducing oxygen available for breathing. 

Vapors may travel to areas away from work site before 

igniting/flashing back to vapor source. 

Fire or intense heat may cause violent rupture of packages. 

Cool closed containers exposed to fire with water spray. 

Do not allow run-off from fire fighting to enter drains or water 

courses. 

In case of fire hazardous decomposition products may be 

produced such as: 

Hydrogen fluoride 

Carbonyl halides 

Carbon monoxide 

Carbon dioxide (CO2) 

Special protective equipment 

for firefighters 

: In the event of fire and/or explosion do not breathe fumes. 

Wear self-contained breathing apparatus and protective suit. 

No unprotected exposed skin areas. 

Further information : In case of fire: Evacuate area. Fight fire remotely due to the 

risk of explosion. 

SECTION 6. ACCIDENTAL RELEASE MEASURES 

Personal precautions : Immediately evacuate personnel to safe areas.

Keep people away from and upwind of spill/leak.

Wear personal protective equipment. Unprotected persons 

must be kept away.

Wear self-contained breathing apparatus and protective suit.

Eliminate all ignition sources if safe to do so.

Avoid skin contact with leaking liquid (danger of frostbite).

Ventilate the area.

Vapors may travel to areas away from work site before 

igniting/flashing back to vapor source.

Vapours are heavier than air and can cause suffocation by 

reducing oxygen available for breathing.

Avoid accumulation of vapours in low areas.

Unprotected personnel should not return until air has been 

tested and determined safe.

Ensure that the oxygen content is >= 19.5%.
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Environmental precautions : Prevent further leakage or spillage if safe to do so.

The product evapourates readily.

Discharge into the environment must be avoided.

Methods for cleaning up : Use explosion-proof equipment.

No sparking tools should be used.

Ventilate the area.

Allow to evapourate.

SECTION 7. HANDLING AND STORAGE 

Handling 

Handling : Handle with care.

Wear personal protective equipment.

Do not breathe vapour.

Avoid contact with skin, eyes and clothing.

Use only in well-ventilated areas.

Pressurized container. Protect from sunlight and do not expose 

to temperatures exceeding 50 °C.

Follow all standard safety precautions for handling and use of 

compressed gas cylinders.

Use authorized cylinders only.

Protect cylinders from physical damage.

Do not puncture or drop cylinders, expose them to open flame 

or excessive heat.

Do not remove screw cap until immediately ready for use.

Always replace cap after use.

Advice on protection 

against fire and explosion 

: Container hazardous when empty.

Prevent the creation of flammable or explosive concentrations 

of vapour in air and avoid vapour concentration higher than the 

occupational exposure limits.

Keep product and empty container away from heat and 

sources of ignition.

Do not pressurize, cut, weld, braze, solder, drill, grind or 

expose containers to heat or sources of ignition.

Take measures to prevent the build up of electrostatic charge.

Electrical equipment should be protected to the appropriate 

standard.

Use explosion-proof equipment.

No sparking tools should be used.

No smoking.
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Storage 

Requirements for storage 

areas and containers 

: Pressurized container: protect from sunlight and do not expose 

to temperatures exceeding 50 °C. Do not pierce or burn, even 

after use.

Keep containers tightly closed in a dry, cool and well-ventilated 

place.

Keep away from heat and sources of ignition.

Storage rooms must be properly ventilated.

Ensure adequate ventilation, especially in confined areas.

Protect cylinders from physical damage.

Store away from incompatible substances.

Store in original container.

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Protective measures : Ensure that eyewash stations and safety showers are close to 

the workstation location.

Do not breathe vapour.

Avoid contact with skin, eyes and clothing.

Engineering measures : Use with local exhaust ventilation.

Eye protection : Safety goggles

Hand protection : Protective gloves

Gloves must be inspected prior to use.

Replace when worn.

Skin and body protection : Avoid skin contact with leaking liquid (danger of frostbite).

Wear suitable protective equipment.

Respiratory protection : No personal respiratory protective equipment normally 

required.

When workers are facing concentrations above the exposure 

limit they must use appropriate certified respirators.

Use NIOSH approved respiratory protection.

Hygiene measures : Handle in accordance with good industrial hygiene and safety 

practice.

Ensure adequate ventilation, especially in confined areas.

When using do not eat, drink or smoke.
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Remove and wash contaminated clothing before re-use.

Keep working clothes separately.

Do not breathe vapour.

Avoid contact with skin, eyes and clothing.

Exposure Guidelines

Components CAS-No. Value Control 

parameters 

Upda

te 

Basis 

2,3,3,3-

Tetrafluoroprop1-ene 

754-12-1 TWA :

time 

weighted 

average 

(500 ppm) 2009 WEEL:US. AIHA 

Workplace 

Environmental 

Exposure Level 

(WEEL) Guides

2,3,3,3-

Tetrafluoroprop1-ene 

754-12-1 TWA :

time 

weighted 

average 

(500 ppm) 03 15 

2010

Honeywell:Limit 

established by 

Honeywell 

International Inc.

2,3,3,3-

Tetrafluoroprop1-ene 

754-12-1 STEL :

Short 

term 

exposure 

limit 

(1,500 ppm) 03 15 

2010

Honeywell:Limit 

established by 

Honeywell 

International Inc.

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES 

Physical state : Liquefied gas

Color : clear 

Odor : slight 

pH : Note: no data available 

Boiling point/boiling range : -29.4 °C 

Flash point : Note: not applicable 
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Evaporation rate : Note: not determined 

lower flammability limit : 6 %(V) 

upper flammability limit : 12.3 %(V) 

Vapor pressure : 6,067 hPa 

at 21.1 °C(70.0 °F) 

 14,203 hPa 

at 54.4 °C(129.9 °F) 

Vapor density : 4 Note: (Air = 1.0) 

Density : 1.1 g/cm3 at 25 °C 

Water solubility : 198.2 mg/l at 24 °C 

Method: 92/69/EEC, A.6 

Partition coefficient: noctanol/water : log Pow: 2.15 

Method: 92/69/EEC, A.8 

Ignition temperature : 405 °C 

Method: Auto-ignition temperature 

Molecular weight : 114 g/mol 

SECTION 10. STABILITY AND REACTIVITY 
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Chemical stability : Stable under normal conditions. 

Possibility of hazardous 

reactions 

: Hazardous polymerisation does not occur. 

Conditions to avoid : Keep away from heat and sources of ignition. 

Pressurized container. Protect from sunlight and do not 

expose to temperatures exceeding 50 °C. 

Do not pressurize, cut, weld, braze, solder, drill, grind or 

expose containers to heat or sources of ignition. 

Decomposes under high temperature. 

Some risk may be expected of corrosive and toxic 

decomposition products. 

Incompatible materials to 

avoid 

: Strong oxidizing agents 

Finely divided aluminium 

Zinc 

Magnesium 

Hazardous decomposition 

products 

: In case of fire hazardous decomposition products may be 

produced such as: 

Hydrogen fluoride 

Carbonyl halides 

Carbon monoxide 

Carbon dioxide (CO2) 

SECTION 11. TOXICOLOGICAL INFORMATION 

Acute inhalation toxicity : LC50: > 400000 ppm 

Exposure time: 4 h 

Species: rat 

Sensitisation : Cardiac sensitization 

Species: dogs 

Result: No effects observed for exposures up to 12% (120,189 

ppm). 

Repeated dose toxicity : Species: rat 

Application Route: Inhalation 

Exposure time: 2 Weeks 

No-observed-effect level: 50000 ppm 
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 : Species: rat 

Application Route: Inhalation 

Exposure time: 4 Weeks 

NOAEL (No observed adverse effect level): 50000 ppm 

 : Species: rat 

Application Route: Inhalation 

Exposure time: 13 Weeks 

NOAEL (No observed adverse effect level): 50000 ppm 

 : Species: rabbit, male 

Application Route: Inhalation 

Exposure time: 28 d 

No-observed-effect level: 500 ppm 

 : Species: rabbit, female 

Application Route: Inhalation 

Exposure time: 28 d 

No-observed-effect level: 1000 ppm 

 : Species: mini-pig 

Application Route: Inhalation 

Exposure time: 28 d 

NOAEL (No observed adverse effect level): 10,000 ppm 

Note: (highest exposure tested). 

Genotoxicity in vitro : Test Method: Ames test 

Result: 20% and higher, positive in TA 100 and e. coli WP2 

uvrA, negative in TA98, TA100, and TA1535. 

 : Test Method: Chromosome aberration test in vitro 

Cell type: Human lymphocytes 

Result: negative 

Note: Dose 760,000 ppm 

 : Test Method: Chromosome aberration test in vitro 

Cell type: Chinese Hamster Lung Cells 

Result: negative 

Genotoxicity in vivo : Species: mouse 

Cell type: Micronucleus 

Dose: up to 200,000 ppm (4 hour) 

Result: negative 
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Genotoxicity in vivo : Test Method: Unscheduled DNA synthesis 

Dose: up to 50,000 ppm (4 weeks) 

Result: negative 

Genotoxicity in vivo : Species: rat 

Cell type: Micronucleus 

Dose: up to 50,000 ppm (4 weeks) 

Result: negative 

Reproductive toxicity : Species: rat 

Application Route: Inhalation exposure 

Exposure time: Two-generation reproductive toxicity 

NOAEL,parent: 50,000 ppm 

NOAEL,F1: 50,000 ppm 

NOAEL,F2: 50,000 ppm 

Teratogenicity : Species: rat 

Dose: NOAEL (No observed adverse effect level) - 50,000 

ppm 

 : Species: rabbit 

Dose: NOAEL (No observed adverse effect level) - 4,000 ppm 

SECTION 12. ECOLOGICAL INFORMATION 

Ecotoxicity effects 

Toxicity to fish : LC50: > 197 mg/l 

Exposure time: 96 h 

Species: Cyprinus carpio (Carp) 

Method: OECD Test Guideline 203 

Note: No demonstrable toxic effect in saturated solution. 

Toxicity to daphnia and other 

aquatic invertebrates

: EC50: > 83 mg/l 

Exposure time: 48 h 

Species: Daphnia magna (Water flea) 

Method: OECD Test Guideline 202 
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Toxicity to algae : EC50: > 100 mg/l 

Species: Scenedesmus capricornutum (fresh water algae) 

Elimination information (persistence and degradability) 

Biodegradability : Result: Not readily biodegradable. 

Further information on ecology 

SECTION 13. DISPOSAL CONSIDERATIONS 

Disposal methods : Observe all Federal, State, and Local Environmental 

regulations. 

SECTION 14. TRANSPORT INFORMATION 

DOT UN/ID No. : UN 3161

Proper shipping name : LIQUEFIED GAS, FLAMMABLE, N.O.S. 

( R-1234yf) 

Class 2.1 

Packing group 

Hazard Labels 2.1

IATA UN/ID No. : UN 3161 

Description of the goods : LIQUEFIED GAS, FLAMMABLE, N.O.S. 

 ( R-1234yf) 

Class : 2.1 

Hazard Labels : 2.1 

Packing instruction (cargo 

aircraft) 

: 200 

IMDG UN/ID No. : UN 3161 

Description of the goods : LIQUEFIED GAS, FLAMMABLE, N.O.S. 

 ( R-1234yf) 

Class : 2.1 

Hazard Labels : 2.1 

EmS Number : F-D, S-U 
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Marine pollutant : no 

SECTION 15. REGULATORY INFORMATION 

Inventories 

US. Toxic Substances 

Control Act 

: On TSCA Inventory 

Australia. Industrial 

Chemical (Notification and 

Assessment) Act 

: Not in compliance with the inventory 

: 2,3,3,3-Tetrafluoroprop-1-ene 754-12-1 

Canada. Canadian 

Environmental Protection 

Act (CEPA). Domestic 

Substances List (DSL) 

: All components of this product are on the Canadian DSL. 

Japan. Kashin-Hou Law 

List 

: On the inventory, or in compliance with the inventory 

Korea. Toxic Chemical 

Control Law (TCCL) List 

: On the inventory, or in compliance with the inventory 

Philippines. The Toxic 

Substances and Hazardous 

and Nuclear Waste Control 

Act 

: Not in compliance with the inventory 

: 2,3,3,3-Tetrafluoroprop-1-ene 754-12-1 

China. Inventory of Existing 

Chemical Substances 

: Not in compliance with the inventory 

: 2,3,3,3-Tetrafluoroprop-1-ene 754-12-1 

New Zealand. Inventory of 

Chemicals (NZIoC), as 

published by ERMA New 

Zealand 

: Not in compliance with the inventory 

: 2,3,3,3-Tetrafluoroprop-1-ene 754-12-1 

TSCA 12B : US. Toxic Substances Control Act (TSCA) Section 12(b) Export 

Notification (40 CFR 707, Subpt D) 
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 2,3,3,3-Tetrafluoroprop-1-ene 754-12-1 

National regulatory information 

US. Toxic Substances 

Control Act (TSCA) Section 

5(a)(2) Final Significant 

New Use Rules (SNURs) 

(40 CFR 721, Subpt E) 

: 

: Issued. 

: 2,3,3,3-Tetrafluoroprop-1-ene 754-12-1 

SARA 302 Components : SARA 302: No chemicals in this material are subject to the 

reporting requirements of SARA Title III, Section 302. 

SARA 313 Components : SARA 313: This material does not contain any chemical 

components with known CAS numbers that exceed the 

threshold (De Minimis) reporting levels established by SARA 

Title III, Section 313. 

SARA 311/312 Hazards : Fire Hazard 

Acute Health Hazard 

Sudden Release of Pressure Hazard 

California Prop. 65 : This product does not contain any chemicals known to State of 

California to cause cancer, birth defects, or any other 

reproductive harm. 

New Jersey RTK : 2,3,3,3-Tetrafluoroprop-1-ene 754-12-1 

Pennsylvania RTK : 2,3,3,3-Tetrafluoroprop-1-ene 754-12-1 

WHMIS Classification : B1: Flammable gas 

A: Compressed Gas 

This product has been classified according to the hazard criteria 

of the CPR and the MSDS contains all of the information 

required by the CPR.
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SECTION 16. OTHER INFORMATION 

HMIS III NFPA

Health hazard : 0 2 

Flammability : 2 2 

Physical Hazard : 2 

Instability : 0 

Hazard rating and rating systems (e.g. HMIS® III, NFPA): This information is intended solely for the 

use of individuals trained in the particular system. 

Further information 

The information provided in this Safety Data Sheet is correct to the best of our knowledge, 

information and belief at the date of its publication. The information given is designed only as a 

guidance for safe handling, use, processing, storage, transportation, disposal and release and is not 

to be considered a warranty or quality specification. The information relates only to the specific 

material designated and may not be valid for such material used in combination with any other 

materials or in any process, unless specified in the text. Final determination of suitability of any 

material is the sole responsibility of the user. This information should not constitute a guarantee for 

any specific product properties. 

Changes since the last version are highlighted in the margin. This version replaces all previous 

versions.

Previous Issue Date: 06/13/2013

Prepared by Honeywell Performance Materials and Technologies Product Stewardship Group