Exhibit 4.15







  




	
AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT

	
  1. CONTRACT ID CODE

	
  PAGE OF PAGES


	 	 	
1

	
2








	
2. AMENDMENT/MODIFICATION NO.   

	
  3. EFFECTIVE DATE

	
  4. REQUISITION/PURCHASE REQ. NO.

	
 5. PROJECT NO. (If applicable)


	
0003

	
  10/13/2016

	 	 
	
6. ISSUED BY

	
CODE  

	
  ASPR-BARDA  

	
  7. ADMINISTERED BY (If other than Item 6)

	
 CODE 

	
ASPR-BARDA01


	 	 
	
ASPR-BARDA

200 Independence Ave., S.W.

Room 640-G

 Washington DC 20201

	
  ASPR-BARDA

  330 Independence Ave, SW, Rm G644

   Washington DC 20201


	    	    






	
8. NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code)

	
  (x)

	
 9A. AMENDMENT OF SOLICITATION NO.


	 	 	 
	MEDIWOUND LTD 1477616	 	
 9B. DATED (SEE ITEM 11)


	MEDIWOUND LTD                   42 HAYARKON	   	 
	42 HAYARKON

 YAVNE     00812	 	
    x

	
 10A. MODIFICATION OF CONTRACT/ORDER NO.

  HHSO100201500035C


	 	 	 	 
	 	 	 	
 10B. DATED (SEE ITEM 13)


	
CODE     1477616

	
  FACILITY CODE

	 	
 09/29/2015








	11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS
	☐	
The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers               ☐ is  extended          ☐ is not extended. Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following  methods: (a) By completing Items 8 and 15, and returning                    copies of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.


	12. ACCOUNTING AND APPROPRIATION DATA (If required)

 See Schedule
	 	
13. THIS ITEM ONLY APPLIES TO MODIFICATION OF CONTRACTS/ORDERS. IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.













	
CHECK ONE

	
A. THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.


	 	
 


	 	
B. THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).


	 	
 


	 	
C. THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:


	 	
 


	
X

	
D. OTHER (Specify type of modification and authority)


Bilateral Modification by mutual agreement of the parties


	
E. IMPORTANT:      Contractor                ☐ is not      ☒ is required to sign this document and return                1               copies to the issuing office.







14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCFsectionheadings, including solicitation/contract subject matter where feasible.)


Tax ID Number:           C0-0000387


DUNS Number:           532040334


PURPOSE: this modification is to adjust the Statement of Work. Please see description attached.







This does not change any amounts obligated in the base contract.







Funds Obligated Prior to this Modification           $40,430,469.00


Funds Obligated with mod     #03     $ 0.00


Total Funds Obligated to Date                                $40,430,469.00







Continued . . .







Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.



	15A. NAME AND TITLE OF SIGNER (Type or print)	 	 16A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print)
	 	 	 	 	 
	 	 	 	 MATTHEW A. ROSE
	 	 	 	 	 
	
15B. CONTRACTOR/OFFEROR


MediWound Ltd.

	
  15C. DATE SIGNED

	 16B. UNITED STATES OF AMERICA	
  16C. DATE SIGNED


	 	 	 	
  1/29/2017

	 	 	 	
  01/29/2017


	 	
(Signature of person authorized to sign)

	 	 	 	
(Signature of Contracting Officer)

	 	 






	
NSN 7540-01-152-8070

Previous edition unusable

	
STANDARD FORM 30 (REV. 10-83)

Prescribed by GSA

FAR (48 CFR) 53.243







 

















	
CONTINUATION SHEET

	
REFERENCE NO. OF DOCUMENT BEING CONTINUED

	
PAGE       OF 


	
HHSO100201500035C/0003

	2	2



NAME OF OFFEROR OR CONTRACTOR


MEDIWOUND LTD 1477616


	
ITEM NO.

(A)

	
SUPPLIES/SERVICES

(B)

	
QUANTITY

(C)

	
UNIT 

(D)

	
UNIT PRICE

(E)

	
AMOUNT


(F)


	 	 	 	 	 	 
	 	
Expiration date: September 28, 2020 (Unchanged)

	 	 	 	 
	 	 	 	 	 	 
	 	
Except as provided herein, all terms and conditions of the contract remains unchanged Period of Performance: 09/29/2015 to 09/28/2020

	 	 	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 
	 	 	 	 	 	 



	
NSN 7540-01-152-8067

		OPTIONAL FORM 336 (4-86) 

Sponsored by GSA 

 FAR (48 CFR) 53.110







 











 






HHSO100201500035C


MOD 3




 


Modify Statement of Work Section J 1.6.4 of the contract by replacement with the following language:


 



	1.6.4	
Agriculture Raw Material Studies (WBS 1.6.4)







 


	
WBS# and Title

	
Milestone

	
Deliverables


	
1.6.4 Agriculture Raw Material Studies

	
[ * * * ]

	
Reports submitted to BARDA CO/PO.





 



	1.6.4.1	
[ * * * ] (WBS 1.6.4.1)







 


Objective/Description of Work: [ * * * ]


 


Milestones:


 


[ * * * ] (WBS 1.6.4.1).


 


Deliverables:


 



		-	
Study protocols will be provided to BARDA for review and approval.







 



		-	
Final study report submitted to BARDA (WBS 1.6.4.1).







 



	1.6.4.2	
[ * * * ] (WBS 1.6.4.2)







 


Objective/Description of Work:  [ * * * ]


 


Milestones:


 


Study and analysis completion (WBS 1.6.4.2).


 


Deliverables:


 



		-	
Study protocols will be provided to BARDA for review and approval.







 



		-	
Final study report submitted to BARDA (WBS 1.6.4.2).







 



	1.6.4.3	
[ * * * ]







 


Objective/Description of Work: [ * * * ]


 


Milestones/Deliverables:


 


[ * * * ]


 



	1.6.4.4	
[ * * * ]







 


Objective/Description of Work: [ * * * ]



Milestones/Deliverables:




 [ * * * ]


 



	1.6.4.5	
 [ * * * ]







 






[ * * * ] Portions of this agreement were omitted and a complete copy of this agreement has been provided separately to the Securities and Exchange Commission pursuant to MediWound’s application requesting confidential treatment under Exchange Act Rule 24b-2.




 











Objective/Description of Work: [ * * * ]


 


Milestones/Deliverables:


 



		·	
[ * * * ]







 



		·	
Study report submitted to BARDA.









 



	1.6.4.6	
cGMP Inspection at [ * * * ]







 


Objective/Description of Work: [ * * * ]


 


Milestones/Deliverables:


 


[ * * * ]


 


Except as provided, all other terms and conditions remain unchanged.


 


(End of Changes)


 






[ * * * ] Portions of this agreement were omitted and a complete copy of this agreement has been provided separately to the Securities and Exchange Commission pursuant to MediWound’s application requesting confidential treatment under Exchange Act Rule 24b-2.