EX-10.18



 Exhibit 10.18 
  

			
	



	  	3050 Spruce Street
	  	St. Louis, MO 63103
	  	Tel (800) 448-0471
	  	Fax (314) 286-7817
	  	www.safcglobal.net

 [*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately
with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 
 Second Amendment
to SGD-1006 
 Commercial Supply Agreement executed on 1 December 2010 and 

First Amendment to Commercial Supply Agreement executed on 

20 January 2014 (the “First Amendment”)(the Commercial Supply 

Agreement together with the First Amendment, the “Supply Agreement”) 

19 September 2016 
 Vaughn Himes 

21823 30th Drive S.E. 

Bothell, WA 98021 
 Dear Vaughn 

This letter agreement (the “Second Amendment”) confirms the Parties’ agreement to amend the Supply Agreement to change the price per gram/per
Batch (the “Price”) for SGD 1006 set forth in Appendix C to the Supply Agreement. The purpose of the pricing revision is to a) capture the cost of the [*] used in the manufacture of SGD-1006, b) capture the operational efficiencies gained
during the manufacturing of the [*] c) capture the increased labor and overhead costs in the [*], and d) capture the [*] inventory remaining from production [*]. Beginning as of January 1, 2017, certain [*], as listed in the second table below,
that were previously provided [*] in accordance with cGMP, Applicable Laws and the Quality Agreement, and the [*]. Through 2016, these [*] had been provided by or purchased separately by [*]. In addition, effective as of January 1, 2017, any
[*] from each batch production will now be owned by [*]. 
 The table below compares the current price per gram under the First Amendment with the Price per
gram effective as of the Effective Date of this Second Amendment. 
  

					
	 SGD-1006 - 300 gm batch
	  	Price per gm	 
	 First Amendment to Commercial Supply Agreement executed on 20 January 2014
	  	 	[*]	 
	 Second Amendment to Commercial Supply Agreement
	  	 	[*]	 

  
  

 

			
	CONFIDENTIAL	 	Page1 of 3








 



 
  
  

The table below itemizes the components of the amended Price. 

[*] 
  

 
 In addition to the [*] in this Second Amendment, SAFC
and Seattle Genetics agree to perform an analysis of the [*] prior to discussing any change to the Price for 2018 to further [*]. 
 The Price as set forth
in this Second Amendment shall be effective as of the first date of Manufacture of the [*]. 
 Terms capitalized, but not defined, herein shall have the
meaning ascribed to them in the Supply Agreement. This Second Amendment shall be effective as of the date of the last signature below (the “Effective Date”). Except as set forth in this Second Amendment, all of the terms and conditions of
the Supply Agreement remain in full force and effect. 
  
  

			
	CONFIDENTIAL	 	Page 2 of 3

 [*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately
with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 







 



 
 IN WITNESS WHEREOF, the parties have executed this Second amendment by their duly authorized representatives, effective as
of the Effective Date. 
 Agreed and accepted: 
  

									
	SAFC, INC	 		 	SEATTLE GENETICS, INC.
					
	By	 	 /s/ Mike Smith
	 		 	By	 	 /s/ Vaughn B. Himes

					
	Name	 	 Mike Smith
	 		 	Name	 	 Vaughn B. Himes

					
	Title	 	 Site Director
	 		 	Title	 	 EVP

					
	Date	 	 November 22, 2016
	 		 	Date	 	 December 2, 2016


  

			
	CONFIDENTIAL	 	Page 3 of 3

 [*] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately
with the Securities and Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended.