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                                                                   Exhibit 10.59

                              CONNETICS CORPORATION
                   RESTRICTED COMMON STOCK PURCHASE AGREEMENT

                                NOVEMBER 5, 1998


        This Common Stock Purchase Agreement (the "Agreement") is entered into
as of this 5th day of November, 1998, between Connetics Corporation, a Delaware
corporation (the "Company") and G. Kirk Raab, an individual ("Purchaser").


                                    SECTION 1
                              SALE OF COMMON STOCK

        1.1 Sale of Common Stock. Subject to the terms and conditions hereof, on
the Closing Date, as defined below, the Company will issue and sell to
Purchaser, and Purchaser will purchase from the Company, an aggregate of 25,000
shares of Common Stock, par value $0.001 per share, of the Company (the "Common
Stock"), for an aggregate purchase price of $2,500.

        1.2 Closing Date. The closing (the "Closing") of the purchase and sale
of the Common Stock shall be held at the offices of the Company, 3400 West
Bayshore Road, Palo Alto, California at 10:00 a.m. on November 6, 1998 or at
such other time and place upon which the Company and Purchaser shall mutually
agree (the date of the Closing is referred to as the "Closing Date").

        1.3 Delivery. At the Closing, the Company will deliver to Purchaser a
certificate or certificates representing the shares of Common Stock purchased by
Purchaser, against payment of the purchase price therefor, by wire transfer or
check drawn on a United States bank.

        1.4 Legend. The certificate(s) for the Common Stock shall be subject to
a legend restricting transfer under the Securities Act of 1933, as amended (the
"SECURITIES ACT") and referring to restrictions on transfer herein, such legend
to be substantially as follows:

        "THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
UNDER THE SECURITIES ACT OF 1933, AND HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT
WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF. NO SUCH
SALE OR DISPOSITION MAY BE EFFECTED WITHOUT (A) AN EFFECTIVE REGISTRATION
STATEMENT RELATED THERETO, OR (B) AN OPINION OF COUNSEL FOR THE COMPANY THAT
SUCH REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OF 1933, AS AMENDED
(THE "ACT"), OR (C) FULL COMPLIANCE WITH THE PROVISIONS OF RULE 144 UNDER THE
ACT."

        1.5 Removal of Legends. Any legend endorsed on a certificate pursuant to
SECTION 1.4 of this Agreement shall be removed (a) if the shares of the Common
Stock represented by such certificate shall have been effectively registered
under the Securities Act or otherwise lawfully



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sold in a public transaction, (b) if such shares may be transferred in
compliance with Rule 144(k) promulgated under the Securities Act, or (c) if the
holder of such shares shall have provided the Company with an opinion of
counsel, in form and substance acceptable to the Company, stating that a public
sale, transfer or assignment of such shares may be made without registration.


                                    SECTION 2
                  REPRESENTATIONS AND WARRANTIES OF THE COMPANY

        The Company hereby represents and warrants to the Purchaser that:

        2.1 Organization. The Company is a corporation duly organized and
validly existing under the laws of the State of Delaware and is in good standing
under such laws. The Company has requisite corporate power and authority to own,
lease and operate its properties and assets, and to carry on its business as
presently conducted.

        2.2 Authorization. The Company has all corporate right, power and
authority to enter into this Agreement and to consummate the transactions
contemplated by this Agreement. All corporate action on the part of the Company,
its directors and stockholders necessary for the authorization, execution,
delivery and performance of this Agreement by the Company, and the
authorization, sale, issuance and delivery of the Common Stock and the
performance of the Company's obligations under this Agreement has been taken.
This Agreement has been duly executed and delivered by the Company and
constitutes a legal, valid and binding obligation of the Company enforceable in
accordance with its terms, subject to laws of general application relating to
bankruptcy, insolvency and the relief of debtors and rules of law governing
specific performance, injunctive relief or other equitable remedies, and to
limitations of public policy. There are no statutory, contractual or other
preemptive rights or rights of first refusal with respect to the issuance and
sale of the Common Stock.

        2.3 Validity of Securities. The Common Stock, when issued, sold and
delivered by the Company in accordance with the terms of this Agreement, will be
duly and validly issued, fully-paid and nonassessable. Based in part upon the
representations of the Purchaser in this Agreement, the offer, sale and issuance
of the Common Stock will be made in compliance with all applicable federal and
state securities laws.

        2.4 No Conflict. The execution and delivery of this Agreement does not,
and the sale of the Common Stock will not, conflict with, or result in any
violation of, or default (with or without notice or lapse of time, or both), or
give rise to a right of termination, cancellation or acceleration of any
obligation or to a loss of a material benefit, under, any provision of the
Certificate of Incorporation or Bylaws of the Company or any agreement or
instrument, permit, license, judgment, order, decree, statute, law, ordinance,
rule or regulation applicable to the Company, its properties or assets, if to do
so would have a material adverse effect on the business, properties, prospects
or financial condition of the Company.

        2.5 Accuracy of Reports; Financial Statements. All reports required to
be filed with the Securities and Exchange Commission (the "SEC") by the Company
from February 1, 1996 (the



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date of the Company's initial public offering) through the date of this
Agreement under the Securities Exchange Act of 1934, as amended (the "EXCHANGE
ACT"), copies of which have been made available to each [sic] Purchaser (the
"SEC DOCUMENTS"), have been duly and timely filed, were in substantial
compliance with the requirements of their respective forms when filed, were
complete and correct in all material respects as of the dates at which the
information was furnished, and contained (as of such dates) no untrue statement
of a material fact nor omitted to state a material fact necessary in order to
make the statements made therein in light of the circumstances in which made not
misleading. The Company's financial statements included in the SEC Documents
(the "FINANCIAL STATEMENTS") comply as to form in all material respects with
applicable accounting requirements and with the published rules and regulations
of the SEC with respect thereto. The Financial Statements have been prepared in
accordance with generally accepted accounting principles consistently applied
and fairly present the consolidated financial position of the Company and any
subsidiaries at the dates thereof and the consolidated results of operations and
consolidated cash flows for the periods then ended (subject, in the case of
unaudited statements, to normal, recurring adjustments).

        2.6 Governmental Consents, Etc. No consent, approval or authorization of
or designation, declaration or filing with any governmental authority on the
part of the Company is required in connection with the valid execution and
delivery of this Agreement, or the consummation of any other transaction
contemplated by this Agreement, except such filings as may be required to be
made with the SEC, the National Association of Securities Dealers, Inc. ("NASD")
and with governmental authorities for purposes of effecting compliance with the
securities and Blue Sky laws in the states in which Common Stock is offered
and/or sold, which compliance will be effected in accordance with such laws.

        2.7 Registration Rights. The Company has not granted or agreed to grant
any rights to register its securities under the Securities Act, including
piggy-back rights, to Purchaser.

        2.8 Rights of Common Stock. The Common Stock shall have the rights,
preferences, privileges and restrictions provided in the Company's Amended and
Restated Certificate of Incorporation.


                                    SECTION 3
                 REPRESENTATIONS AND WARRANTIES OF THE PURCHASER

        Purchaser hereby represents and warrants to the Company as follows:

        3.1 Investment. Purchaser is acquiring the Common Stock for investment
for his own account, not as a nominee or agent and not with a view to or for
resale in connection with any distribution thereof. Purchaser understands that
the Common Stock purchased from the Company pursuant to this Agreement has not
been registered under the Securities Act by reason of a specific exemption from
the registration provisions of the Securities Act which depends upon, among
other things, the bona fide nature of Purchaser's investment intent and the
accuracy of such Purchaser's representations as expressed in this Agreement.
Purchaser acknowledges and understands that the securities must be held
indefinitely unless they are subsequently registered



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under the Securities Act or an exemption from such registration is available.
Purchaser further acknowledges and understands that the Company is under no
obligation to register the securities. Purchaser understands that the
certificate(s) evidencing the securities will be imprinted with a legend that
prohibits the transfer of the securities unless they are registered or such
registration is not required in the opinion of counsel for the Company.

        3.2 Accredited Investor. Purchaser is an "accredited investor" as
defined by Rule 501(a) under the Securities Act of 1933, as amended (the
"SECURITIES ACT"). The SEC documents have been made available to Purchaser, and
Purchaser has received all the information it has requested regarding the
Company. Purchaser has such business and financial experience as is required to
give him the capacity to protect his own interests in connection with the
purchase of the Common Stock.

        3.3 Authority. This Agreement has been duly executed and delivered by
Purchaser and constitutes a legal, valid and binding obligation of the
Purchaser, enforceable in accordance with its terms, subject to laws of general
application relating to bankruptcy, insolvency and the relief of debtors and
rules of law governing specific performance, injunctive relief or other
equitable remedies, and to limitations of public policy. The execution and
delivery of this Agreement does not, and the consummation of the transactions
contemplated by this Agreement will not, conflict with or result in any
violation of any obligation under any judgment, order, decree, statute, law,
ordinance, rule or regulation applicable to the Purchaser.

        3.4 Investigation. Purchaser has had a reasonable opportunity to discuss
the Company's business, management and financial affairs with the Company's
management, and has acquired sufficient information about the Company to reach
an informed and knowledgeable decision to acquire the securities.

        3.5 Tax Consequences. Purchaser understands that he may suffer adverse
tax consequences as a result of the purchase or disposition of the Common Stock.
Purchaser represents that he has consulted any tax consultants he deems
advisable in connection with the purchase or disposition of the Common Stock and
that Purchaser is not relying on the Company for any tax advice.

        3.6 Section 83(b) Election. Purchaser understands that Section 83(a) of
the Internal Revenue Code of 1986, as amended (the "CODE"), taxes as ordinary
income for a nonstatutory stock option and as alternative minimum taxable income
for an incentive stock option the difference between the amount paid for the
Common Stock and the fair market value of the Common Stock. Purchaser
understands that Purchaser may elect to be taxed at the time the Common Stock is
purchased, rather than when and as the Repurchase Option expires, by filing an
election under Section 83(b) (an "83(b) ELECTION") of the Code with the Internal
Revenue Service within 30 days from the date of purchase. Even if the fair
market value of the Common Stock at the time of the execution of this Agreement
equals the amount paid for the Common Stock, the election must be made to avoid
income and alternative minimum tax treatment under Section 83(a) in the future.
Purchaser understands that failure to file such an election in a timely manner
may result in adverse tax consequences for Purchaser. Purchaser further
understands that an additional copy of such election form should be filed with
his federal income tax return for the calendar year in which the date of this
Agreement falls. Purchaser acknowledges that the



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foregoing is only a summary of the effect of United States federal income
taxation with respect to purchase of the Common Stock hereunder, and does not
purport to be complete. Purchaser further acknowledges that the Company has
directed Purchaser to seek independent advice regarding the applicable
provisions of the Code, the income tax laws of any municipality, state or
foreign country in which Purchaser may reside, and the tax consequences of
Purchaser's death.

         Purchaser agrees that he will execute and deliver to the Company with
this executed Agreement a copy of the Acknowledgment and Statement of Decision
Regarding Section 83(b) Election (the "ACKNOWLEDGMENT") attached to this
Agreement as EXHIBIT A. Purchaser further agrees that he will execute and submit
with the Acknowledgment a copy of the 83(b) Election attached to this Agreement
either as EXHIBIT B (for income tax purposes in connection with the early
exercise of a nonstatutory stock option) or EXHIBIT C (for alternative minimum
tax purposes in connection with the early exercise of an incentive stock option)
if Purchaser has indicated in the Acknowledgment his decision to make such an
election.


                                    SECTION 4
                   CONDITIONS TO OBLIGATIONS OF THE PURCHASER

        Purchaser's obligations to the Company under this Agreement are subject
to the fulfillment, on or before the Closing, of each of the following
conditions, unless otherwise waived:

        4.1 Representations and Warranties Correct. The representations and
warranties made by the Company in SECTION 2 shall be true and correct in all
material respects on the Closing Date with the same effect as though such
representations and warranties had been made on and as of the Closing Date.

        4.2 No Law Prohibiting or Restricting Sale. There shall not be in effect
any law, rule or regulation prohibiting or restricting such sale, or requiring
any consent or approval of any person which shall not have been obtained to
issue the Common Stock (except as otherwise referenced in this Agreement).


                                    SECTION 5
                    CONDITIONS TO OBLIGATIONS OF THE COMPANY

        The obligations of the Company under this Agreement are subject to the
fulfillment on or prior to the Closing of each of the following conditions,
unless otherwise waived:

        5.1 Representations and Warranties Correct. The representations and
warranties made by the Purchaser in SECTION 3 of this Agreement shall be true
and correct in all material respects on and as of the Closing Date with the same
effect as though such representations and warranties had been made on and as of
the Closing Date.

        5.2 No Order Pending.  There shall not then be in effect any order
enjoining or restraining the transactions contemplated by this Agreement.



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        5.3 No Law Prohibiting or Restricting Such Sale. There shall not be in
effect any law, rule or regulation prohibiting or restricting such sale, or
requiring any consent or approval of any person which shall not have been
obtained to issue the Common Stock (except as otherwise provided in this
Agreement).


                                    SECTION 6
                                  MISCELLANEOUS

        6.1 Governing Law. This Agreement and all acts and transactions pursuant
to this Agreement and the rights and obligations of the parties to this
Agreement shall be governed, construed and interpreted in accordance with the
laws of the State of California, without giving effect to principles of
conflicts of law.

        6.2 Survival. Unless otherwise set forth in this Agreement, the
warranties, representations and covenants of the Company and Purchaser contained
in or made pursuant to this Agreement shall survive the execution and delivery
of this Agreement and the Closing.

        6.3 Successors and Assigns. This Agreement shall be binding upon and
shall inure to the benefit of the parties to this Agreement and their respective
successors and assigns.

        6.4 Entire Agreement; Amendment. This Agreement and the other documents
delivered pursuant to this Agreement constitute the full and entire
understanding and agreement between the parties with regard to the subject
matter hereof and supersede all prior agreements and understandings among the
parties relating to the subject matter of this Agreement. Neither this Agreement
nor any of its terms may be amended, waived, discharged or terminated other than
by a written instrument signed by the party against which enforcement of any
such amendment, waiver, discharge or termination is sought.

        6.5 Notices and Dates. Unless otherwise provided in this Agreement, any
notice required or permitted by this Agreement shall be in writing and shall be
deemed sufficient upon delivery, when delivered personally or by overnight
courier and addressed to the party to be notified at such party's address as set
forth on the signature page to this Agreement or as subsequently modified by
written notice. If any date provided for in this Agreement falls on a Saturday,
Sunday or legal holiday, such date shall be deemed extended to the next business
day.

        6.6 Brokers. Neither Purchaser nor the Company has engaged, consented to
or authorized any broker, finder or intermediary to act on his or its behalf,
directly or indirectly, as a broker, finder or intermediary in connection with
the transactions contemplated by this Agreement. Each of the Company and the
Purchaser agree to indemnify and hold harmless the other party from and against
all fees, commissions or other payments owing to any party acting on his or its
behalf.

        6.7 Severability. If any term, provision, covenant or restriction of
this Agreement is held by a court of competent jurisdiction to be invalid, void
or unenforceable, the remainder of



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the terms, provisions, covenants and restrictions of this Agreement shall remain
in full force and effect and shall in no way be affected, impaired or
invalidated.

        6.8 Captions and Headings. The captions and headings used herein are for
convenience and ease of reference only and are not intended to be a part of or
to affect the meaning or interpretation of this Agreement.

        6.9 Counterparts. This Agreement may be executed in counterparts, and
each such counterpart shall be deemed an original for all purposes.

        IN WITNESS WHEREOF, the parties to this Agreement have executed or
caused their respective authorized officers to execute this Agreement as of the
first date written above.



"COMPANY"

Connetics Corporation                           Address:



By: /s/ T. Wiggans                              3400 West Bayshore Road
   ------------------------------------         Palo Alto, California 94303
   Thomas G. Wiggans                            Facsimile:  (650) 843-2899
   President and Chief Executive Officer



"PURCHASER"



      /s/ G. Kirk Raab                          314 Wyndham Drive              
--------------------------------                Portola Valley, CA 94028
          G. Kirk Raab



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