CASRN Chemical PMID Response LEL_or_HDT_DoseUnits MC.Sum Species

50-28-2 Estradiol 3616 Active 0.000125 mg6 rat

143-50-0 Chlordecone 93289 Active6 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 109951 Active 0.000312 mg/day6 rat

50-27-1 Estriol 174891 Active 0.002 mg/rat/day6 rat

50-28-2 Estradiol 174891 Active 0.00005 mg/rat/day6 rat

521-18-6 Dihydrotestosterone 177269 Active 0.2 mg/rat/day6 rat

50-28-2 Estradiol 564791 Active 0.00002 mg/day6 rat

56-53-1 Diethylstilbestrol 564791 Inactive NA NA6 rat

10540-29-1 Tamoxifen 591813 Active 0.00025 mg/day6 rat

10540-29-1 Tamoxifen 591813 Active 0.0005 mg/day6 rat

50-28-2 Estradiol 591813 Active 0.00002 mg/day6 rat

10540-29-1 Tamoxifen 1805462 Active 0.0005 mg/day6 rat

50-28-2 Estradiol 1805462 Active 0.00001 mg/day6 rat

10540-29-1 Tamoxifen 1933854 Active1 mg/kg/day6 rat

10540-29-1 Tamoxifen 1933854 Active 0.1 mg/kg/day6 rat

10540-29-1 Tamoxifen 1962598 Active 0.32 mg/kg/day6 rat

50-28-2 Estradiol 2362436 Active 0.0001 mg/day6 rat

17924-92-4 Zearalenone 2951527 Active 0.4 mg/day6 rat

50-28-2 Estradiol 2951527 Active 0.00033 mg/day6 rat

50-28-2 Estradiol 3660440 Active 0.000002 mg/day6 rat

84-16-2 Hexestrol 3660440 Active 0.000001 mg/day6 rat

53-16-7 Estrone 3951331 Active 0.01 mg/day6 rat

50-28-2 Estradiol 4689748 Active 0.00009 mg/day6 rat

50-28-2 Estradiol 4725783 Active 0.0001 mg(total dose)6 rat

57-63-6 ethinyl estradiol 4725783 Active 0.00005 mg(total dose)6 rat

72-33-3 Mestranol 4725783 Active 0.0003 mg (total dose)6 rat

56-53-1 Diethylstilbestrol 5581648 Active 0.0001 mg (total dose)6 rat

789-02-6 o,p'-DDT 5772860 Active1 mg/kg6 rat

10540-29-1 Tamoxifen 6431104 Active 0.001 mg/rat/day6 rat

10540-29-1 Tamoxifen 6538611 Active 0.01 mg/kg/day6 rat

10540-29-1 Tamoxifen 7128917 Active 0.001 mg/day6 rat

50-28-2 Estradiol 7128917 Active 0.00003 mg/day6 rat

50-27-1 Estriol 7365751 Active NA NA 6 rat

50-28-2 Estradiol 7365751 Active NA NA 6 rat

53-16-7 Estrone 7365751 Active NA NA 6 rat

57-63-6 Ethinyl Estradiol 7365751 Active NA NA 6 rat
72-33-3 Mestranol 7365751 Active NA NA 

6 rat

10540-29-1 Tamoxifen 7382727 Active 0.005 mg/day6 rat

77-06-5 Gibberellic acid 7442448 Active 0.0001 mg6 mouse

77-06-5 Gibberellic acid 7442448 Active 0.0001 mg6 mouse

10540-29-1 Tamoxifen 7470748 Active 0.001 mg/day6 rat

57-63-6 Ethinyl estradiol 7470748 Active 0.000005 mg/day6 rat

72-33-3 Mestranol 7470748 Active 0.00008 mg/day6 rat

50-27-1 Estriol 8954758 Active NA NA 6 rat

50-27-1 Estriol 8954758 Active NA NA 6 rat

50-28-2 Estradiol 8954758 Active NA NA 6 rat

50-28-2 Estradiol 8954758 Active NA NA 6 rat

53-16-7 Estrone 8954758 Active NA NA 6 rat

53-16-7 Estrone 8954758 Active NA NA 6 rat

56-53-1 Diethylstilbestrol 8954758 Active NA NA 6 rat

56-53-1 Diethylstilbestrol 8954758 Active NA NA 6 rat

57-63-6 Ethinyl estradiol 8954758 Active NA NA 6 rat

57-63-6 Ethinyl estradiol 8954758 Active NA NA 6 rat

9005-65-6 Polysorbate 80 9096282 Inactive 5000 mg/kg/day6 rat

50-28-2 Estradiol 9192820 Active 0.000045 mg/day6 mouse

53-16-7 Estrone 9192820 Active 0.000045 mg/day6 mouse

10540-29-1 Tamoxifen 9275080 Active 0.037152 mg/kg/day6 rat

637-07-0 Clofibrate 9339486 Inactive8 mg/kg/day6 rat

637-07-0 Clofibrate 9339486 Inactive 20 mg/kg/day6 rat

637-07-0 Clofibrate 9339486 Inactive 20 mg/kg/day6 rat

637-07-0 Clofibrate 9339486 Inactive 200 mg/kg/day6 rat

637-07-0 Clofibrate 9339486 Inactive 200 mg/kg/day6 rat

65-85-0 Benzoic acid 9339486 Inactive1 mg/kg/day6 rat

65-85-0 Benzoic acid 9339486 Inactive1 mg/kg/day6 rat

80-05-7 Bisphenol A 9799186 Active 400 mg/kg/day6 rat

80-05-7 Bisphenol A 9799186 Active 400 mg/kg/day6 rat

94-26-8 Butylparaben 9875295 Active 200 mg/kg/day6 rat

94-26-8 Butylparaben 9875295 Inactive 400 mg/kg/day6 rat

94-26-8 Butylparaben 9875295 Active 400 mg/kg/day6 rat

94-26-8 Butylparaben 9875295 Active 600 mg/kg/day6 rat

94-26-8 Butylparaben 9875295 Active 800 mg/kg/day6 rat

99-76-3 Methylparaben 9875295 Inactive 80 mg/kg/day6 rat

99-76-3 Methylparaben 9875295 Inactive 800 mg/kg/day6 rat
50-28-2 17B- Estradiol 10028405 Active 0.05 mg/kg/day

6 rat

56-53-1 Diethylstilbestrol 10028405 Active 0.002 mg/kg/day6 rat

104-40-5 p-nonylphenol 10513683 Active 75 mg/kg/day6 rat

520-36-5 Apigenin 10720651 Active5 mg/kg/day6 rat

94-26-8 Butylparaben 10722885 Active 100 mg/kg/day6 rat

57-63-6 17B- Estradiol 11020455 Active 0.1 mg/kg/day6 rat

57-91-0 17a-estradiol 11020455 Active 0.4 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11218048 Active 0.001 mg/kg/day6 rat

80-05-7 Bisphenol A 11258963 Active 800 mg/kg6 rat

80-05-7 Bisphenol A 11258963 Active 200 mg/kg6 rat

107-46-0 Hexamethyldisiloxane 11509742 Inactive 1200 mg/kg/day6 rat

556-67-2 Octamethylcyclotetrasiloxane (D4) 11509742 Active 250 mg/kg/day6 rat

556-67-2 Octamethylcyclotetrasiloxane (D4) 11509742 Active 250 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0001 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0001 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0001 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0001 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0001 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0001 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0001 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0001 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day6 rat
57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day

6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11564613 Active 0.003 mg/kg/day6 rat

104-40-5 p-nonylphenol 11731037 Inactive2 mg/kg/day6 rat

104-40-5 p-nonylphenol 11731037 Inactive 200 mg/kg/day6 rat

104-40-5 p-nonylphenol 11731037 Active 200 mg/kg/day6 rat

104-40-5 p-nonylphenol 11750080 Inactive 200 mg/kg/day6 rat

119-61-9 Benzophenone 11750080 Inactive 200 mg/kg/day6 rat

140-66-9 4-tert-octylphenol 11750080 Active 200 mg/kg/day6 rat

1461-22-9 Tributyltin chloride 11750080 Inactive 200 mg/kg/day6 rat

17924-92-4 Zearalenone 11750080 Active 20 mg/kg/day6 rat

1806-26-4 4-n-octylphenol 11750080 Inactive 200 mg/kg/day6 rat

2467-02-9 Bisphenol F 11750080 Active 20 mg/kg/day6 rat

446-72-0 Genistein 11750080 Active 20 mg/kg/day6 rat

474-86-2 Equilin 11750080 Active2 mg/kg/day6 rat

50-28-2 Estradiol 11750080 Active2 mg/kg/day6 rat

521-18-6 Dihydrotestosterone 11750080 Active 200 mg/kg/day6 rat

53-16-7 Estrone 11750080 Active2 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11750080 Active 0.002 mg/kg/day6 rat

599-64-4 P-cumylphenol 11750080 Active 200 mg/kg/day6 rat

68-22-4 Norethindrone 11750080 Active 20 mg/kg/day6 rat

77-40-7 Bisphenol B 11750080 Active 200 mg/kg/day6 rat

797-63-7 Norgestrel 11750080 Active 20 mg/kg/day6 rat

80-05-7 Bisphenol A 11750080 Active 20 mg/kg/day6 rat
84-61-7 Dicyclohexylphthalate 11750080 Inactive 200 mg/kg/day

6 rat

84-74-2 Dibutyl phthalate 11750080 Inactive 200 mg/kg/day6 rat

302-79-4 trans-retinoic acid 11751013 Inactive 25 mg/kg/day6 rat

104-51-8 n-butylbenzene 11876503 Inactive 2000 mg/kg/day6 rat

57-63-6 Ethinyl estradiol 11876503 Active 0.0006 mg/kg6 rat

51630-58-1 Fenvalerate 12052007 Inactive 80 mg/kg/day6 rat

52645-53-1 Permethrin 12052007 Inactive 150 mg/kg/day6 rat

66230-04-4 Esfenvalerate 12052007 Inactive 20 mg/kg/day6 rat

80-05-7 Bisphenol A 12062901 Inactive 1000 mg/kg/day6 rat

56-53-1 Diethylstilbestrol 12075118 Active 0.00005 mg/kg6 rat

104-40-5 p-nonylphenol 12128099 Active 100 mg/kg/day6 rat

52918-63-5 Deltamethrin 12202052 Inactive4 mg/kg/day6 rat

446-72-0 Genistein 12415423 Active5 mg/kg6 rat

446-72-0 Genistein 12415423 Active 20 mg/kg6 rat

446-72-0 Genistein 12415423 Active 20 mg/kg6 rat

80-05-7 Bisphenol A 12415423 Inactive 10 mg/kg/day6 rat

80-05-7 Bisphenol A 12415423 Inactive 10 mg/kg/day6 rat

80-05-7 Bisphenol A 12415423 Inactive 10 mg/kg/day6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12415423 Active 100 mg/kg6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12415423 Active 100 mg/kg6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12415423 Active 100 mg/kg6 rat

104-40-5 p-nonylphenol 12453737 Active 200 mg/kg/day6 rat

80-05-7 Bisphenol A 12453737 Active 200 mg/kg/day6 rat

104-43-8 p-Dodecyl-phenol 12504345 Active 40 mg/kg/day6 rat

131-55-5 2,2',4,4'-Tetrahydroxybenzophenone 12504345 Active 200 mg/kg/day6 rat

1478-61-1 4,4'-(Hexafluoroisopropylidene)diphenol 12504345 Active8 mg/kg/day6 rat

58-18-4 Methyltestosterone 12504345 Active 10 mg/kg/day6 rat

80-46-6 p-(Tert-pentyl)phenol 12504345 Active 200 mg/kg/day6 rat

26002-80-2 d-phenothrin 12628315 Inactive 1000 mg/kg/day6 rat

131-55-5 2,2',4,4'-Tetrahydroxybenzophenone 12765246 Active 200 mg/kg/day6 rat

1478-61-1 4,4'-(Hexafluoroisopropylidene)diphenol 12765246 Active8 mg/kg/day6 rat

80-46-6 p-(tert)-Pentyl)phenol 12765246 Active 200 mg/kg/day6 rat

1806-26-4 Ocytlphenol 12849853 Active 100 mg/kg/day6 rat

446-72-0 Genistein 12849853 Active 100 mg/kg/day6 rat

520-18-3 Kaempferol 12849853 Inactive 200 mg/kg/day6 rat

520-36-5 Apigenin 12849853 Inactive 200 mg/kg/day6 rat

80-05-7 Bisphenol A 12849853 Inactive 200 mg/kg/day6 rat
446-72-0 Genistein 12948896 Active

1 mg/kg/day6 rat

446-72-0 Genistein 12948896 Active 15 mg/kg/day6 rat

446-72-0 Genistein 12948896 Active 15 mg/kg/day6 rat

446-72-0 Genistein 12948896 Active 15 mg/kg/day6 rat

446-72-0 Genistein 12948896 Active 15 mg/kg/day6 rat

446-72-0 Genistein 12948896 Active 15 mg/kg/day6 rat

446-72-0 Genistein 12948896 Active 15 mg/kg/day6 rat

446-72-0 Genistein 12948896 Active 15 mg/kg/day6 rat

446-72-0 Genistein 12948896 Active 20 mg/kg/day6 rat

446-72-0 Genistein 12948896 Active 20 mg/kg/day6 rat

446-72-0 Genistein 12948896 Active 35 mg/kg/day6 rat

446-72-0 Genistein 12948896 Active 60 mg/kg/day6 rat

446-72-0 Genistein 12948896 Active 60 mg/kg/day6 rat

446-72-0 Genistein 12948896 Active 60 mg/kg/day6 rat

72-43-5 Methoxychlor 12948896 Active 20 mg/kg/day6 rat

72-43-5 Methoxychlor 12948896 Active 20 mg/kg/day6 rat

72-43-5 Methoxychlor 12948896 Active 20 mg/kg/day6 rat

72-43-5 Methoxychlor 12948896 Active 50 mg/kg/day6 rat

72-43-5 Methoxychlor 12948896 Active 50 mg/kg/day6 rat

72-43-5 Methoxychlor 12948896 Active 100 mg/kg/day6 rat

72-43-5 Methoxychlor 12948896 Active 100 mg/kg/day6 rat

72-43-5 Methoxychlor 12948896 Active 100 mg/kg/day6 rat

72-43-5 Methoxychlor 12948896 Active 100 mg/kg/day6 rat

72-43-5 Methoxychlor 12948896 Active 100 mg/kg/day6 rat

72-43-5 Methoxychlor 12948896 Active 100 mg/kg/day6 rat

72-43-5 Methoxychlor 12948896 Active 100 mg/kg/day6 rat

72-43-5 Methoxychlor 12948896 Active 100 mg/kg/day6 rat

72-43-5 Methoxychlor 12948896 Active 100 mg/kg/day6 rat

789-02-6 o,p'-DDT 12948896 Active 10 mg/kg/day6 rat

789-02-6 o,p'-DDT 12948896 Active 50 mg/kg/day6 rat

789-02-6 o,p'-DDT 12948896 Active 50 mg/kg/day6 rat

789-02-6 o,p'-DDT 12948896 Active 50 mg/kg/day6 rat

789-02-6 o,p'-DDT 12948896 Active 50 mg/kg/day6 rat

789-02-6 o,p'-DDT 12948896 Active 50 mg/kg/day6 rat

789-02-6 o,p'-DDT 12948896 Active 50 mg/kg/day6 rat

789-02-6 o,p'-DDT 12948896 Inactive 100 mg/kg/day6 rat

789-02-6 o,p'-DDT 12948896 Active 100 mg/kg/day6 rat

789-02-6 o,p'-DDT 12948896 Active 100 mg/kg/day6 rat
789-02-6 o,p'-DDT 12948896 Active 200 mg/kg/day

6 rat

789-02-6 o,p'-DDT 12948896 Active 200 mg/kg/day6 rat

789-02-6 o,p'-DDT 12948896 Active 200 mg/kg/day6 rat

789-02-6 o,p'-DDT 12948896 Active 200 mg/kg/day6 rat

80-05-7 Bisphenol A 12948896 Active 10 mg/kg/day6 rat

80-05-7 Bisphenol A 12948896 Active 10 mg/kg/day6 rat

80-05-7 Bisphenol A 12948896 Active 10 mg/kg/day6 rat

80-05-7 Bisphenol A 12948896 Active 100 mg/kg/day6 rat

80-05-7 Bisphenol A 12948896 Active 100 mg/kg/day6 rat

80-05-7 Bisphenol A 12948896 Active 100 mg/kg/day6 rat

80-05-7 Bisphenol A 12948896 Active 100 mg/kg/day6 rat

80-05-7 Bisphenol A 12948896 Active 100 mg/kg/day6 rat

80-05-7 Bisphenol A 12948896 Active 100 mg/kg/day6 rat

80-05-7 Bisphenol A 12948896 Active 100 mg/kg/day6 rat

80-05-7 Bisphenol A 12948896 Active 100 mg/kg/day6 rat

80-05-7 Bisphenol A 12948896 Active 100 mg/kg/day6 rat

80-05-7 Bisphenol A 12948896 Active 100 mg/kg/day6 rat

80-05-7 Bisphenol A 12948896 Active 300 mg/kg/day6 rat

80-05-7 Bisphenol A 12948896 Active 300 mg/kg/day6 rat

80-05-7 Bisphenol A 12948896 Active 300 mg/kg/day6 rat

80-05-7 Bisphenol A 12948896 Active 375 mg/kg/day6 rat

80-05-7 Bisphenol A 12948896 Active 375 mg/kg/day6 rat

80-05-7 Bisphenol A 12948896 Inactive 600 mg/kg/day6 rat

80-05-7 Bisphenol A 12948896 Active 600 mg/kg/day6 rat

80-05-7 Bisphenol A 12948896 Active 600 mg/kg/day6 rat

80-05-7 Bisphenol A 12948896 Active 1000 mg/kg/day6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12948896 Active5 mg/kg/day6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12948896 Active 35 mg/kg/day6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12948896 Active 35 mg/kg/day6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12948896 Active 35 mg/kg/day6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12948896 Active 35 mg/kg/day6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12948896 Active 75 mg/kg/day6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12948896 Active 75 mg/kg/day6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12948896 Active 75 mg/kg/day6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12948896 Active 75 mg/kg/day6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12948896 Active 75 mg/kg/day6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12948896 Inactive 80 mg/kg/day6 rat
84852-15-3 Nonylphenol (mixture of branched chains) 12948896 Inactive 80 mg/kg/day 6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12948896 Active 80 mg/kg/day 6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12948896 Active 80 mg/kg/day 6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12948896 Active 80 mg/kg/day 6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12948896 Active 80 mg/kg/day 6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12948896 Active 80 mg/kg/day 6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12948896 Active 80 mg/kg/day 6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12948896 Active 100 mg/kg/day 6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12948896 Active 100 mg/kg/day 6 rat

84852-15-3 Nonylphenol (mixture of branched chains) 12948896 Active 100 mg/kg/day 6 rat

53-16-7 Estrone 13173415 Active 0.0006 mg(total dose) 6 rat

556-67-2 Octamethylcyclotetrasiloxane (D4) 14575643 Active 250 mg/kg/day 6 mouse

50-41-9 clomiphene citrate 14643963 Active 2 mg/kg/day 6 rat

5153-25-3 2-ethylhexyl-p-hydroxybenzoate 14643963 Active 200 mg/kg/day 6 rat

80-09-1 4,4'-sulfonyldiphenol 14643963 Active 20 mg/kg/day 6 rat

84-75-3 phthalic acid di-n-hexyl ester 14643963 Inactive 1000 mg/kg/day 6 rat

98-54-4 p-t-Butylphenol 14643963 Active 100 mg/kg/day 6 rat

104-40-5 p-nonylphenol 14981825 Active 90 mg/kg/day 6 rat

446-72-0 Genistein 15064164 Active 2.5 mg/kg/day 6 rat

446-72-0 Genistein 15064164 Active 2.5 mg/kg/day 6 rat

446-72-0 Genistein 15064164 Inactive 5 mg/kg/day 6 rat

446-72-0 Genistein 15064164 Active 10 mg/kg/day 6 rat

446-72-0 Genistein 15064164 Active 10 mg/kg/day 6 rat

446-72-0 Genistein 15064164 Active 15 mg/kg/day 6 rat

50-28-2 Estradiol 15064164 Active 0.0001 mg/kg/day 6 rat

50-28-2 Estradiol 15064164 Active 0.001 mg/kg/day 6 rat

50-28-2 Estradiol 15064164 Active 0.001 mg/kg/day 6 rat

56-53-1 Diethylstilbestrol 15064164 Active 0.00025 mg/kg/day 6 rat

56-53-1 Diethylstilbestrol 15064164 Active 0.00025 mg/kg/day 6 rat

57-63-6 Ethinyl estradiol 15064164 Active 0.0001 mg/kg/day 6 rat

57-63-6 Ethinyl estradiol 15064164 Active 0.0001 mg/kg/day 6 rat

57-63-6 Ethinyl estradiol 15064164 Active 0.00015 mg/kg/day 6 rat

72-43-5 Methoxychlor 15064164 Active 50 mg/kg/day 6 rat

72-43-5 Methoxychlor 15064164 Active 50 mg/kg/day 6 rat

72-43-5 Methoxychlor 15064164 Active 50 mg/kg/day 6 rat

80-05-7 Bisphenol A 15064164 Active 30 mg/kg/day 6 rat

80-05-7 Bisphenol A 15064164 Active 75 mg/kg/day 6 rat
80-05-7 Bisphenol A 15064164 Active 75 mg/kg/day 6 rat

80-05-7 Bisphenol A 15064164 Active 75 mg/kg/day 6 rat

80-05-7 Bisphenol A 15064164 Active 300 mg/kg/day 6 rat

57-63-6 Ethinyl estradiol 15147785 Active 0.0002 mg/kg/day 6 rat

33089-61-1 Amitraz 15350676 Inactive 50 mg/kg/day 6 rat

80-05-7 Bisphenol A 15456929 Active 200 mg/kg/day 6 rat

80-05-7 Bisphenol A 15456929 Active 400 mg/kg/day 6 rat

50-28-2 Estradiol 15596252 Active 0.0005 mg/kg/day 6 rat

80-05-7 Bisphenol A 15596252 Active 50 mg/kg/day 6 rat

52645-53-1 Permethrin 15599112 Active 800 mg/kg/day 6 rat

120-47-8 Ethyl paraben 15697177 Active 180 mg/kg/day 6 rat

94-13-3 Propyl paraben 15697177 Active 65 mg/kg/day 6 rat

94-26-8 Butyl paraben 15697177 Active 70 mg/kg/day 6 rat

99-76-3 Methyl paraben 15697177 Active 55 mg/kg/day 6 rat

99-96-7 p-hydroxybenzoic acid 15697177 Inactive 150 mg/kg/day 6 rat

50-28-2 Estradiol 15763248 Active 0.01 mg/kg/day 6 rat

82640-04-8 Raloxifene HCl 15961563 Active 0.5 mg/kg/day 6 rat

17924-92-4 Zearalenone 17097287 Active 2 mg/kg/day 6 mouse

140-66-9 4-tert-octylphenol (OP) 17222880 Active 56 mg/kg/day 6 rat

319-85-7 hexachlorocyclohexane (HCH) 17222880 Active 3 mg/kg/day 6 rat

72-43-5 Methoxychlor (MXC) 17222880 Active 23 mg/kg/day 6 rat

789-02-6 o,p-DDT 17222880 Active 14 mg/kg/day 6 rat

6422-86-2 di-2-ethylhexylterephthalate 17849488 Inactive 2000 mg/kg/day 6 rat

103-23-1 Di (2-ethylhexyl) adipate= Bis(2-ethylhexyl)adipate 17904329 Inactive 1000 mg/kg/day 6 rat

104-43-8 p-Dodecyl-phenol 17904329 Active 40 mg/kg/day 6 rat

106-46-7 p-Dichlorobenzene 17904329 Inactive 1000 mg/kg/day 6 rat

117-81-7 Di(2-ethylhexyl) phthalate 17904329 Inactive 1000 mg/kg/day 6 rat

120-47-8 Ethyl-p-hydroxybenzoate 17904329 Inactive 1000 mg/kg/day 6 rat

131-18-0 Di-n-pentyl phthalate 17904329 Inactive 1000 mg/kg/day 6 rat

131-55-5 2,2',4,4' -Tetrahydroxybenzophenone 17904329 Active 229.7858739 mg/kg/day 6 rat

131-56-6 2,4-Dihydroxybenzophenone 17904329 Active 100.198222 mg/kg/day 6 rat

13311-84-7 Flutamide 17904329 Inactive 1000 mg/kg/day 6 rat

135-19-3 2-Naphthol 17904329 Inactive 1000 mg/kg/day 6 rat

1478-61-1 4,4'-(Hexafluoroisopropylidene)diphenol 17904329 Active 4 mg/kg/day 6 rat

149-30-4 2-Benzothiazolethiol = 2-Mercaptobenzothiazole 17904329 Inactive 1000 mg/kg/day 6 rat

17804-35-2 Benomyl 17904329 Inactive 1000 mg/kg/day 6 rat

1912-24-9 Atrazine 17904329 Inactive 1000 mg/kg/day 6 rat
2425-06-1 Captafol; 1,2,3,6-Tetrahydro-N-(1,1,2,2-tetrachloroethylthio)phthalimide 17904329 Inactive 1000 mg/kg/day 6 rat

50-28-2 17B- Estradiol 17904329 Active 0.001012062 mg/kg/day 6 rat

50-41-9 Clomiphene citrate (cis and trans mixture)17904329 Active 2 mg/kg/day 6 rat

5153-25-3 2-Ethylhexyl-4-hydroxybenzoate 17904329 Active 200 mg/kg/day 6 rat

58-18-4 Methyltestosterone = 17a-Methyltestosterone 17904329 Active 10 mg/kg/day 6 rat

61-82-5 3-Amino-1,2,4-triazole 17904329 Inactive 1000 mg/kg/day 6 rat

77-47-4 Hexachlorocyclopentadiene 17904329 Inactive 1000 mg/kg/day 6 rat

80-09-1 4,4' -Sulfonyldiphenol 17904329 Active 20 mg/kg/day 6 rat

80-46-6 p-(tert-Pentyl) phenol = p-(tert-Amyl) phenol 17904329 Active 202.0667245 mg/kg/day 6 rat

84-66-2 Diethylphthalate 17904329 Inactive 1000 mg/kg/day 6 rat

84-75-3 Di-n-hexyl phthalate 17904329 Inactive 1000 mg/kg/day 6 rat

87-86-5 Pentachlorophenol 17904329 Inactive 1000 mg/kg/day 6 rat

96-76-4 2,4-Di-tert-butylphenol 17904329 Inactive 1000 mg/kg/day 6 rat

97-77-8 Disulfiram 17904329 Inactive 1000 mg/kg/day 6 rat

98-54-4 p-tert-Butylphenol 17904329 Active 99.24936976 mg/kg/day 6 rat

99-96-7 p-Hydroxybenzoic acid 17904329 Inactive 1000 mg/kg/day 6 rat

56-55-3 benz[a]anthracene 18634860 Active 1 mg/kg/day 6 rat

61-82-5 Amitrole 18779953 Inactive 1000 mg/kg/day 6 rat

57-63-6 ethinyl estradiol 18830443 Active 0.0001 mg/kg/day 6 rat

51630-58-1 fenvalerate 18923997 Inactive 40 mg/kg/day 6 rat

446-72-0 Genistein 19239007 Active 100 mg/kg/day 6 rat

40487-42-1 Pendimethalin 19897005 Active 300 mg/kg/day 6 rat

140-66-9 p-tert-octylphenol 20391140 Inactive 250 mg/kg/day 6 rat

57-63-6 Ethinyl estradiol 20981862 Active 0.003 mg/kg/day 6 rat

50-28-2 Estradiol 21783589 Active 0.001 mg/kg/day 6 rat

82-68-8 Pentachloronitrobenzene 21783589 Inactive 800 mg/kg/day 6 rat

87-86-5 Pentachlorophenol 21783589 Inactive 10 mg/kg/day 6 rat

3380-34-5 Triclosan 22062131 Active 7.5 mg/kg/day 6 rat

118-58-1 Benzyl salicylate (BzS) 22197706 Active 3.7 mg/kg/day 6 rat

1085-12-7 Benzoic acid, 4-hydroxy-, heptyl ester 23037998 Inactive 1000 mg/kg/day 6 mouse

1085-12-7 Benzoic acid, 4-hydroxy-, heptyl ester 23037998 Inactive 1000 mg/kg/day 6 mouse

114369-43-6 Fenbuconazole 23037998 Inactive 1000 mg/kg/day 6 mouse

114369-43-6 Fenbuconazole 23037998 Inactive 1000 mg/kg/day 6 mouse

120-47-8 Ethylparaben [NF] 23037998 Inactive 1000 mg/kg/day 6 mouse

120-47-8 Ethylparaben [NF] 23037998 Inactive 1000 mg/kg/day 6 mouse

131-55-5 2,2',4,4'-Tetrahydroxybenzophenone 23037998 Active 300 mg/kg/day 6 mouse

131-55-5 2,2',4,4'-Tetrahydroxybenzophenone 23037998 Active 1000 mg/kg/day 6 mouse
131-56-6 2,4-Dihydroxybenzophenone 23037998 Active 300 mg/kg/day

6 mouse

131-56-6 2,4-Dihydroxybenzophenone 23037998 Active 1000 mg/kg/day6 mouse

131-57-7 Oxybenzone 23037998 Inactive 1000 mg/kg/day6 mouse

131-57-7 Oxybenzone 23037998 Inactive 1000 mg/kg/day6 mouse

2440-22-4 Drometrizole 23037998 Inactive 1000 mg/kg/day6 mouse

2440-22-4 Drometrizole 23037998 Inactive 1000 mg/kg/day6 mouse

446-72-0 Genistein 23037998 Active 200 mg/kg/day6 mouse

486-66-8 Daidzein 23037998 Active 600 mg/kg/day6 mouse

500-38-9 Nordihydroguaiaretic acid 23037998 Inactive 1000 mg/kg/day6 mouse

500-38-9 Nordihydroguaiaretic acid 23037998 Inactive 1000 mg/kg/day6 mouse

50-55-5 Reserpine 23037998 Inactive3 mg/kg/day6 mouse

50-55-5 Reserpine 23037998 Active3 mg/kg/day6 mouse

51-24-1 Tiratricol 23037998 Active 1000 mg/kg/day6 mouse

51-24-1 Tiratricol 23037998 Active 1000 mg/kg/day6 mouse

520-18-3 Kaempferol 23037998 Inactive 1000 mg/kg/day6 mouse

520-18-3 Kaempferol 23037998 Inactive 1000 mg/kg/day6 mouse

53-70-3 Dibenz[a,h]anthracene 23037998 Inactive 300 mg/kg/day6 mouse

53-70-3 Dibenz[a,h]anthracene 23037998 Inactive 300 mg/kg/day6 mouse

56-55-3 Benz(a)anthracene 23037998 Inactive 300 mg/kg/day6 mouse

56-55-3 Benz(a)anthracene 23037998 Inactive 300 mg/kg/day6 mouse

77-09-8 Phenolphthalein 23037998 Inactive 1000 mg/kg/day6 mouse

77-09-8 Phenolphthalein 23037998 Inactive 1000 mg/kg/day6 mouse

79-94-7 2,2',6,6'-Tetrabromobisphenol A 23037998 Inactive 1000 mg/kg/day6 mouse

79-94-7 2,2',6,6'-Tetrabromobisphenol A 23037998 Inactive 1000 mg/kg/day6 mouse

80-05-7 Bisphenol A 23037998 Active 100 mg/kg/day6 mouse

81131-70-6 Pravastatin sodium 23037998 Inactive 1000 mg/kg/day6 mouse

81131-70-6 Pravastatin sodium 23037998 Inactive 1000 mg/kg/day6 mouse

94-13-3 Propylparaben 23037998 Inactive 1000 mg/kg/day6 mouse

94-13-3 Propylparaben 23037998 Inactive 1000 mg/kg/day6 mouse

94-26-8 Butylparaben 23037998 Inactive 1000 mg/kg/day6 mouse

94-26-8 Butylparaben 23037998 Active 1000 mg/kg/day6 mouse

99-65-0 1,3-Dinitrobenzene 23037998 Inactive 10 mg/kg/day6 mouse

99-65-0 1,3-Dinitrobenzene 23037998 Inactive 30 mg/kg/day6 mouse

50-28-2 17B- Estradiol 23220609 Active 0.005 mg/kg/day6 rat

50-28-2 17B- Estradiol 23220609 Active 0.4 mg/kg/day6 rat

94-18-8 Benzylparaben 23220609 Active 0.16 mg/kg/day6 rat
57-63-6 ethinyl estradiol 24708211 Active 0.0003 mg/kg 6 rat

10605-21-7 Carbendazim 24863245 Inactive 400 mg/kg/day 6 rat

103-23-1 di(2-Ethylhexyl)adipate NICEATM_CERI_METI Inactive 1000 mg/kg/day 6 rat

104-40-5 p-nonylphenol NICEATM_CERI_METI Inactive 200 mg/kg/day 6 rat

104-43-8 p -Dodecyl-phenol NICEATM_CERI_METI Active 40 mg/kg/day 6 rat

117-81-7 di(2-Ethylhexyl)phthalate NICEATM_CERI_METI Inactive 1000 mg/kg/day 6 rat

119-61-9 Benzophenone NICEATM_CERI_METI Inactive 200 mg/kg/day 6 rat

119-61-9 Benzophenone NICEATM_CERI_METI Active 500 mg/kg/day 6 rat

131-55-5 2,2',4,4'-Tetrahydroxybenzophenone NICEATM_CERI_METI Active 200 mg/kg/day 6 rat

140-66-9 4-tert -Octylphenol NICEATM_CERI_METI Active 200 mg/kg/day 6 rat

1461-22-9 Tributyltin chloride NICEATM_CERI_METI Inactive 200 mg/kg/day 6 rat

1478-61-1 4,4'-(Hexafluoroisopropylidene)diphenol NICEATM_CERI_METI Active 4 mg/kg/day 6 rat

17924-92-4 Zearalenone NICEATM_CERI_METI Active 2 mg/kg/day 6 rat

1806-26-4 4-n-octylphenol NICEATM_CERI_METI Inactive 200 mg/kg/day 6 rat

446-72-0 Genistein NICEATM_CERI_METI Active 20 mg/kg/day 6 rat

474-86-2 Equilin NICEATM_CERI_METI Active 2 mg/kg/day 6 rat

486-66-8 Daidzein NICEATM_CERI_METI Inactive 200 mg/kg/day 6 rat

521-18-6 5a-dihydrotestosterone NICEATM_CERI_METI Active 20 mg/kg/day 6 rat

53-16-7 Estrone NICEATM_CERI_METI Active 2 mg/kg/day 6 rat

57-63-6 Ethinyl estradiol NICEATM_CERI_METI Active 0.0002 mg/kg/day 6 rat

57-91-0 17a-estradiol NICEATM_CERI_METI Active 2 mg/kg/day 6 rat

58-18-4 17a-methyl testosterone NICEATM_CERI_METI Active 10 mg/kg/day 6 rat

599-64-4 p-cumylphenol NICEATM_CERI_METI Active 20 mg/kg/day 6 rat

68-22-4 Norethindrone NICEATM_CERI_METI Active 2 mg/kg/day 6 rat

72-43-5 Methoxychlor NICEATM_CERI_METI Inactive 200 mg/kg/day 6 rat

77-40-7 Bisphenol B NICEATM_CERI_METI Active 20 mg/kg/day 6 rat

80-05-7 Bisphenol A NICEATM_CERI_METI Active 2 mg/kg/day 6 rat

80-46-6 p -(tert- Pentyl)phenol NICEATM_CERI_METI Active 200 mg/kg/day 6 rat

84-61-7 Dicyclohexyl phthalate NICEATM_CERI_METI Inactive 1000 mg/kg/day 6 rat

84-66-2 Diethyl phthalate NICEATM_CERI_METI Inactive 2000 mg/kg/day 6 rat

84-74-2 di-n -Butyl phthalate NICEATM_CERI_METI Inactive 1000 mg/kg/day 6 rat

131-70-4 monobutyl phthalate NICEATM_Brady_2000 Inactive 1000 mg/kg/day 6 rat

85-68-7 butyl benzyl phthalate NICEATM_Brady_2000 Inactive 2240 mg/kg/day 6 rat

85-68-7 butyl benzyl phthalate NICEATM_Brady_2000 Inactive 5000 mg/kg/day 6 rat

94-26-8 Butylparaben NICEATM_Goswami_2012 Active 50 mg/kg/day 6 mouse
Type Admin.RouteINJorORAL First.Dose.Age If.OVX..age.at.OVX Elapsed.time.between.OVX.and.RX Duration.days #.of.animals.in.estrogen.control.group #.of.animals.in.RX.group Reference.Estrogen Is.there.a.Vehicle.RX.control. Indicated.that.Diet.is.low.PE. necropsy.time.after.last.dose #.of.doses.used

OVX s.c. INJ PND 70 ~8 weeks 2 weeks 3 12 12 Estradiol 1 NA 24 hr 2

Immature s.c. INJ PND 21 NA NA 3 5 5 Estradiol 1 NA 24 hr 4

Immature p.o. ORAL PND 21 NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 4

Immature s.c. INJ PND 21 NA NA 3 >=5 >=5 Estradiol 1 NA 24 hr 4

Immature s.c. INJ PND 21 NA NA 3 >=5 >=5 Estradiol 1 NA 24 hr 4

Immature s.c. INJ PND 20 - 23NA NA 3 5 5 Estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 21 NA NA 3 5 5 Estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 21 NA NA 3 5 5 Estradiol 1 NA 24 hr 4

Immature p.o. ORAL PND 21 NA NA 3 8 8 E2 (s.c.) 1 NA 24 hr 5

Immature s.c. INJ PND 21 NA NA 3 8 8 E2 (s.c.) 1 NA 24 hr 4

Immature s.c. INJ PND 21 NA NA 3 8 8 E2 (s.c.) 1 NA 24 hr 4

Immature s.c. INJ PND 20 - 23NA NA 3 5 5 Estradiol 1 NA 24 hr 6

Immature s.c. INJ PND 20 - 23NA NA 3 5 5 Estradiol 1 NA 24 hr 5

Immature s.c. INJ PND 21 NA NA 4 5 5 Estradiol 1 NA 24 hr 2

Immature s.c. INJ PND 19 - 21NA NA 4 5 5 Estradiol benzoate 1 NA 24 hr 4

Immature p.o. ORAL PND 20 NA NA 3 10 10 Estradiol 1 NA 24 hr 5

Immature s.c. INJ PND 22 NA NA 3 10 10 Estradiol 1 NA 24 hr 4

Immature p.o. ORAL PND 19 NA NA 3 5 to 10 9 to 10 Estradiol 1 NA 24 hrs 13

Immature p.o. ORAL PND 19 NA NA 3 5 to 10 9 to 10 Estradiol 1 NA 24 hrs 13

Immature s.c. INJ PND 21 NA NA 3 6 to 8 6 to 8 Estradiol 1 NA 24 hr 4

Immature s.c. INJ PND 21 NA NA 3 6 to 10 6 to 8 Estradiol 1 NA 24 hr 4

Immature s.c. INJ PND 20 NA NA 3 7 7 Estrone 1 NA 24 hr 3

Immature s.c. INJ PND 21 NA NA 3 5 5 Estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 19 - 21NA NA 3 5 5 Estradiol 1 NA 24 hr 5

Immature s.c. INJ PND 19 - 21NA NA 3 5 5 Ethinyl estradiol 1 NA 24 hr 4

Immature s.c. INJ PND 19 - 21NA NA 3 5 5 Ethinyl estradiol 1 NA 24 hr 3

Immature p.o. ORAL PND 21 NA NA 3 18-24 18-24 Diethylstilbestrol 1 NA 24 hr 3

Immature i.p. INJ PND 19 NA NA 3 6 6 Estradiol 1 NA 18 hr 4

Immature s.c. INJ PND 19 - 20NA NA 3 24 6 Estradiol 1 NA 24 hr 4

Immature p.o. ORAL PND 18 NA NA 3 5 5 Estradiol benzoate 1 NA 24 hr 4

Immature s.c. INJ PND 22 NA NA 3 8 8 Estradiol 1 NA 24 hr 4

Immature s.c. INJ PND 22 NA NA 3 8 8 Estradiol 1 NA 24 hr 4

Immature p.o. ORAL PND 21 NA NA 3 8 to 10 8 to 10 Estrone 1 NA 24 hr 3

Immature p.o. ORAL PND 21 NA NA 3 8 to 10 8 to 10 Estrone 1 NA 24 hr 3

Immature p.o. ORAL PND 21 NA NA 3 8 to 10 8 to 10 Estrone 1 NA 24 hr 3

Immature p.o. ORAL PND 21 NA NA 3 8 to 10 8 to 10 Estrone 1 NA 24 hr 3
Immature p.o. ORAL PND 21 NA NA 3 8 to 10 8 to 10 Estrone 1 NA 24 hr 3

Immature s.c. INJ PND 19 - 20NA NA 3 6 6 Estradiol 1 NA 24 hr 6

OVX s.c. INJ PND 70 PND 56 2 weeks 5 7 7 Estradiol 1 NA 24 hr 2

OVX s.c. INJ PND 110 PND 56 6 weeks 5 7 7 Estradiol 1 NA 24 hr 2

Immature s.c. INJ PND 19 NA NA 3 >7 >7 Estradiol benzoate 1 NA 24 hr 5

Immature s.c. INJ PND 19 NA NA 3 >7 >7 Estradiol benzoate 1 NA 24 hr 5

Immature s.c. INJ PND 19 NA NA 3 >7 >7 Estradiol benzoate 1 NA 24 hr 5

Immature s.c. INJ PND 19 NA NA 3 10 10 ethinylestradiol 1 NA 24 hr 3

Immature p.o. ORAL PND 19 NA NA 3 10 10 ethinylestradiol 1 NA 24 hr 3

Immature s.c. INJ PND 19 NA NA 3 10 10 ethinylestradiol 1 NA 24 hr 3

Immature p.o. ORAL PND 19 NA NA 3 10 10 ethinylestradiol 1 NA 24 hr 3

Immature s.c. INJ PND 19 NA NA 3 10 10 ethinylestradiol 1 NA 24 hr 3

Immature p.o. ORAL PND 19 NA NA 3 10 10 ethinylestradiol 1 NA 24 hr 3

Immature s.c. INJ PND 19 NA NA 3 10 10 ethinylestradiol 1 NA 24 hr 3

Immature p.o. ORAL PND 19 NA NA 3 10 10 ethinylestradiol 1 NA 24 hr 3

Immature s.c. INJ PND 19 NA NA 3 10 10 ethinylestradiol 1 NA 24 hr 3

Immature p.o. ORAL PND 19 NA NA 3 10 10 ethinylestradiol 1 NA 24 hr 3

Immature p.o. ORAL PND 21 NA NA 3 6 6 Estradiol benzoate 1 NA 24 hr 5

OVX i.p. INJ PND 42 NA ?4 Days 3 6 to 8 6 to 8 Estradiol 1 NA 18 hr 4

OVX i.p. INJ PND 42 NA ?4 Days 3 6 to 8 6 to 8 Estrone 1 NA 18 hr 4

Immature p.o. ORAL PND 21 NA NA 3 5 5 Estradiol 1 NA 24 hr 6

Immature p.o. ORAL PND 21 - 22NA NA 3 5 10 E2 1 NA 24 hr 4

Immature p.o. ORAL PND 21 - 22NA NA 3 3 5 E2 1 NA 24 hr 2

Immature p.o. ORAL PND 21 - 22NA NA 3 5 5 E2 1 NA 24 hr 2

Immature p.o. ORAL PND 21 - 22NA NA 3 5 5 to 10 E2 1 NA 24 hr 4

OVX p.o. ORAL PND 63 7 wk 2 wk 3 7 6 to 7 E2 1 NA 24 hr 2

Immature s.c. INJ PND 21 - 22NA NA 3 5 5 to 10 E2 or Estradiol benzoate 1 NA 24 hr 3

Immature s.c. INJ PND 21 - 22NA NA 3 5 5 to 10 E2 or Estradiol benzoate 1 NA 24 hr 2

Immature s.c. INJ PND 21 NA NA 3 5 7 DES 1 NA 24 hr 2 to 3

Immature p.o. ORAL PND 21 NA NA 3 5 7 DES 1 NA 24 hr 2 to 3

Immature s.c. INJ PND 21 - 22NA NA 3 5 5 17b-estradiol 1 NA 24 hr 3 to 5

Immature p.o. ORAL PND 21 - 22NA NA 3 5 5 17b-estradiol 1 NA 24 hr 3 to 5

Immature s.c. INJ PND 21 - 22NA NA 3 5 5 17b-estradiol 1 NA 24 hr 3 to 5

Immature s.c. INJ PND 21 - 22NA NA 3 5 5 17b-estradiol 1 NA 24 hr 3 to 5

OVX s.c. INJ PND 56 - 706 - 8 weeks old 2 weeks 3 5 5 Estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 21 - 22NA NA 3 5 5 17b-estradiol 1 NA 24 hr 3 to 5

Immature p.o. ORAL PND 21 - 22NA NA 3 5 5 17b-estradiol 1 NA 24 hr 3 to 5
Immature s.c. INJ PND 21 NA NA

3 10 10 E2, DES1 NA 24 hr 2+

Immature s.c. INJ PND 21 NA NA3 10 10 E2, DES1 NA 24 hr >2

Immature p.o. ORAL PND 21 - 22NA NA355 E2 (s.c.)1 NA 24 hr4

OVX p.o. ORAL PND 21 - 23NA NA788 Ethinyl estradiol 1 NA 24 hr5

Immature s.c. INJ PND 19 - 21NA NA3 10 10 Estradiol benzoate 1 NA 24 hr3

Immature p.o. ORAL PND 22 - 23NA NA3 NA 5 to 25 E21 NA 24 hr 5+

Immature p.o. ORAL PND 22 - 23NA NA3 NA 5 to 25 E21 NA 24 hr 5+

Immature s.c. INJ PND 21 NA NA366 Ethinyl estradiol 1 NA 24 hr4

Immature s.c. INJ PND 21 - 22NA NA3 10 10 E21 NA 24 hr7

Immature p.o. ORAL PND 21 - 22NA NA3 10 10 Ethinyl estradiol 1 NA 24 hr8

Immature p.o. ORAL PND 18 NA NA4 12 12 Estradiol1 NA 18-24 hr 2 to 6

Immature p.o. ORAL PND 21 NA NA4 12 12 Estradiol1 NA 18-24 hr 2 to 6

Immature p.o. ORAL PND 18 NA NA4 12 12 Estradiol1 NA 18-24 hr 2 to 6

Immature s.c. INJ PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature s.c. INJ PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature s.c. INJ PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

OVX s.c. INJ Adult 6 weeks 14 - 28 days3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

OVX s.c. INJ Adult 6 weeks 14 - 28 days7 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

OVX s.c. INJ Adult 6 weeks 14 - 28 days7 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

OVX s.c. INJ Adult 6 weeks 14 - 28 days7 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

OVX s.c. INJ Adult 6 weeks 14 - 28 days3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature s.c. INJ PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature s.c. INJ PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature s.c. INJ PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature s.c. INJ PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature s.c. INJ PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature s.c. INJ PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature s.c. INJ PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature s.c. INJ PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature s.c. INJ PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature p.o. ORAL PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature p.o. ORAL PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature p.o. ORAL PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature p.o. ORAL PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

OVX s.c. INJ Adult 6 weeks 14 - 28 days3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

OVX s.c. INJ Adult 6 weeks 14 - 28 days7 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

OVX s.c. INJ Adult 6 weeks 14 - 28 days3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

OVX s.c. INJ Adult 6 weeks 14 - 28 days3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5
OVX s.c. INJ Adult 6 weeks 14 - 28 days3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr

5

OVX s.c. INJ Adult 6 weeks 14 - 28 days3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

OVX s.c. INJ Adult 6 weeks 14 - 28 days3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature p.o. ORAL PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature p.o. ORAL PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature p.o. ORAL PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature p.o. ORAL PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature p.o. ORAL PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature p.o. ORAL PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature p.o. ORAL PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature p.o. ORAL PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature p.o. ORAL PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature p.o. ORAL PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature p.o. ORAL PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

OVX s.c. INJ Adult 6 weeks 14 - 28 days3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature p.o. ORAL PND 18 NA NA3 6 to 10 6 to 10 Ethinyl estradiol 1 NA 24 hr5

Immature s.c. INJ PND 21 NA NA355 Estradiol1 NA 24 hr3

OVX s.c. INJ PND 63 6 weeks 3 weeks355 Estradiol1 NA 24 hrs5

Immature s.c. INJ PND 21 NA NA355 Estradiol1 NA 24 hr2

Immature s.c. INJ PND 20 - 22NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 20 - 22NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 20 - 22NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 20 - 22NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 20 - 22NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 20 - 22NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 20 - 22NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 20 - 22NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 20 - 22NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 20 - 22NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 20 - 22NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 20 - 22NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 20 - 22NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 20 - 22NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 20 - 22NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 20 - 22NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 20 - 22NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 20 - 22NA NA366 Estradiol1 NA 24 hr3
Immature s.c. INJ PND 20 - 22NA NA 3 6 6 Estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 20 - 22NA NA 3 6 6 Estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 5 5 Ethinyl estradiol 1 NA 24 hr 2

Immature s.c. INJ PND 19 NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 4

Immature s.c. INJ PND 19 NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 1

OVX p.o. ORAL PND 56 6 wk 2 wk 3 6 6 Ethynyl estradiol and Methoxychlor 1 NA 24 hr 3

OVX p.o. ORAL PND 56 6 wk 2 wk 3 6 6 Ethynyl estradiol and Methoxychlor 1 NA 24 hr 3

OVX p.o. ORAL PND 56 6 wk 2 wk 3 6 6 Ethynyl estradiol and Methoxychlor 1 NA 24 hr 3

Immature s.c. INJ PND 18 NA NA 3 5 5 E2 1 1 24 hr 1

Immature s.c. INJ PND 20 - 21NA NA 3 NA at least 10 NA 1 NA 24 hr 8

Immature s.c. INJ PND 20 NA NA 3 10 10 DES 1 NA 24 hr 5

Immature p.o. ORAL PND 20 - 22NA NA 3 10 9 to 10 Estradiol hexahydrobenzoate 1 NA 24 hr 2

Immature s.c. INJ PND 20 NA NA 3 6 6 EE 1 1 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 EE 1 1 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 EE 1 1 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 Ethinyl estradiol 1 1 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 Ethinyl estradiol 1 1 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 Ethinyl estradiol 1 1 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 Ethinyl estradiol 1 1 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 Ethinyl estradiol 1 1 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 Ethinyl estradiol 1 1 24 hr 3

Immature s.c. INJ PND 21 NA NA 3 5 5 Estradiol 1 NA 24 hr 4

Immature s.c. INJ PND 21 NA NA 3 5 5 Estradiol 1 NA 24 hr 4

Immature s.c. INJ PND 19 - - 3 6 6 E2 1 NA 24 hrs 3

Immature s.c. INJ PND 19 - - 3 6 6 E2 1 NA 24 hrs 3

Immature s.c. INJ PND 19 - - 3 6 6 E2 1 NA 24 hrs 3

Immature s.c. INJ PND 19 - - 3 6 6 E2 1 NA 24 hrs 3

Immature s.c. INJ PND 19 - - 3 6 6 E2 1 NA 24 hrs 3

Immature p.o. ORAL PND 20 NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 19 NA NA 3 6 6 ethynyl estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 19 NA NA 3 6 6 ethynyl estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 19 NA NA 3 6 6 ethynyl estradiol 1 NA 24 hr 3

Immature p.o. ORAL PND 22 NA NA 4 10 8 or 10 Estradiol 1 NA 24 hr 4

Immature p.o. ORAL PND 22 NA NA 4 10 8 or 10 Estradiol 1 NA 24 hr 4

Immature p.o. ORAL PND 22 NA NA 4 10 8 to 10 Estradiol 1 NA 24 hr 4

Immature p.o. ORAL PND 22 NA NA 4 10 8 to 10 Estradiol 1 NA 24 hr 4

Immature p.o. ORAL PND 22 NA NA 4 10 8 or 10 Estradiol 1 NA 24 hr 4
Immature s.c. INJ PND 18 NA NA

366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 846 weeks 14 - 28 days366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 846 weeks 14 - 28 days366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 846 weeks 14 - 28 days766 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 846 weeks 14 - 28 days766 Ethinyl estradiol 1 NA 24 hr >3

Immature p.o. ORAL PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature p.o. ORAL PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 846 weeks 14 - 28 days366 Ethinyl estradiol 1 NA 24 hr >3

Immature p.o. ORAL PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature p.o. ORAL PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

OVX p.o. ORAL PND 56 - 846 weeks 14 - 28 days766 Ethinyl estradiol 1 NA 24 hr >3

Immature p.o. ORAL PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature p.o. ORAL PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature p.o. ORAL PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature p.o. ORAL PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

OVX p.o. ORAL PND 56 - 846 weeks 14 - 28 days766 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 846 weeks 14 - 28 days366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 846 weeks 14 - 28 days366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 846 weeks 14 - 28 days366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 846 weeks 14 - 28 days766 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 846 weeks 14 - 28 days766 Ethinyl estradiol 1 NA 24 hr >3

Immature p.o. ORAL PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature p.o. ORAL PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature p.o. ORAL PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature p.o. ORAL PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 846 weeks 14 - 28 days366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 846 weeks 14 - 28 days766 Ethinyl estradiol 1 NA 24 hr >3

OVX p.o. ORAL PND 56 - 846 weeks 14 - 28 days766 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 846 weeks 14 - 28 days366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 846 weeks 14 - 28 days766 Ethinyl estradiol 1 NA 24 hr >3
Immature s.c. INJ PND 18 NA NA

366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 846 weeks 14 - 28 days366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 846 weeks 14 - 28 days366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 846 weeks 14 - 28 days366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 846 weeks 14 - 28 days366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 846 weeks 14 - 28 days366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 846 weeks 14 - 28 days366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 856 weeks 14 - 28 days766 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 866 weeks 14 - 28 days766 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature p.o. ORAL PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature p.o. ORAL PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

OVX p.o. ORAL PND 56 - 876 weeks 14 - 28 days766 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature p.o. ORAL PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature p.o. ORAL PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 866 weeks 14 - 28 days366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 896 weeks 14 - 28 days766 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 906 weeks 14 - 28 days766 Ethinyl estradiol 1 NA 24 hr >3

Immature p.o. ORAL PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature p.o. ORAL PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature p.o. ORAL PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature p.o. ORAL PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

OVX p.o. ORAL PND 56 - 916 weeks 14 - 28 days766 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3
OVX s.c. INJ PND 56 - 856 weeks 14 - 28 days3

66 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 846 weeks 14 - 28 days366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 18 NA NA366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 876 weeks 14 - 28 days366 Ethinyl estradiol 1 NA 24 hr >3

OVX s.c. INJ PND 56 - 886 weeks 14 - 28 days366 Ethinyl estradiol 1 NA 24 hr >3

Immature s.c. INJ PND 22 - 23 NA NA3 16 to 20 16 to 20 Estrone1 NA 24 hr3

OVX p.o. ORAL PND 63 - 70PND 42-49 14 days355 Estradiol1 NA 24 hr7

Immature s.c. INJ PND 20 NA NA366 Ethynyl estradiol 1 NA 24 hr3

Immature s.c. INJ PND 20 NA NA366 Ethynyl estradiol 1 NA 24 hr3

Immature s.c. INJ PND 20 NA NA366 Ethynyl estradiol 1 NA 24 hr3

Immature s.c. INJ PND 20 NA NA366 Ethynyl estradiol 1 NA 24 hr3

Immature s.c. INJ PND 20 NA NA366 Ethynyl estradiol 1 NA 24 hr3

Immature p.o. ORAL PND 21 NA NA3 10 10 Estradiol benzoate 1 NA 24 hr3

Immature s.c. INJ PND 19 - 20NA NA388 Ethinyl estradiol 1 NA 24 hr4

Immature s.c. INJ PND 19 - 20NA NA388 Ethinyl estradiol 1 NA 24 hr5

Immature s.c. INJ PND 19 - 20NA NA388 Ethinyl estradiol 1 NA 24 hr2

Immature s.c. INJ PND 19 - 20NA NA388 Ethinyl estradiol 1 NA 24 hr2

Immature s.c. INJ PND 19 - 20NA NA388 Ethinyl estradiol 1 NA 24 hr2

Immature s.c. INJ PND 19 - 20NA NA3 12 12 Ethinyl estradiol 1 NA 24 hr3

Immature s.c. INJ PND 19 - 20NA NA388 Ethinyl estradiol 1 NA 24 hr2

Immature s.c. INJ PND 19 - 20NA NA388 Ethinyl estradiol 1 NA 24 hr2

Immature s.c. INJ PND 19 - 20NA NA388 Ethinyl estradiol 1 NA 24 hr2

Immature s.c. INJ PND 19 - 20NA NA388 Ethinyl estradiol 1 NA 24 hr2

Immature s.c. INJ PND 19 - 20NA NA388 Ethinyl estradiol 1 NA 24 hr2

Immature s.c. INJ PND 19 - 20NA NA388 Ethinyl estradiol 1 NA 24 hr2

Immature s.c. INJ PND 19 - 20NA NA388 Ethinyl estradiol 1 NA 24 hr2

Immature s.c. INJ PND 19 - 20NA NA388 Ethinyl estradiol 1 NA 24 hr2

Immature s.c. INJ PND 19 - 20NA NA388 Ethinyl estradiol 1 NA 24 hr2

Immature s.c. INJ PND 19 - 20NA NA388 Ethinyl estradiol 1 NA 24 hr2

Immature s.c. INJ PND 19 - 20NA NA388 Ethinyl estradiol 1 NA 24 hr2

Immature s.c. INJ PND 19 - 20NA NA388 Ethinyl estradiol 1 NA 24 hr4

Immature s.c. INJ PND 19 - 20NA NA388 Ethinyl estradiol 1 NA 24 hr2
Immature s.c. INJ PND 19 - 20NA NA

388 Ethinyl estradiol 1 NA 24 hr2

Immature s.c. INJ PND 19 - 20NA NA388 Ethinyl estradiol 1 NA 24 hr2

Immature s.c. INJ PND 19 - 20NA NA3 12 12 Ethinyl estradiol 1 NA 24 hr3

Immature p.o. ORAL PND 21 NA NA3 5 to 9 5 to 9 Ethinyl estradiol 1 NA 24 hr3

Immature i.p. INJ PND 21 NA NA3 NA6 None1 NA 24 hr2

Immature p.o. ORAL PND 19 - 20NA NA3 5 to 10 5 to 10 17-b estradiol 1 NA 4, 24 hr8

Immature p.o. ORAL PND 19 - 20NA NA3 5 to 10 5 to 10 17-b estradiol 1 NA 4, 24 hr8

OVX s.c. INJ PND 84 8 Weeks 4 weeks355 Estradiol11 24 hr2

OVX s.c. INJ PND 84 8 Weeks 4 weeks355 Estradiol11 24 hr3

Immature s.c. INJ PND 19 NA NA3 8 to 12 8 to 12 Estradiol1 NA 24 hr5

Immature s.c. INJ PND 21 NA NA3 30 11 to 18 Estradiol1 NA 24 hr4

Immature s.c. INJ PND 21 NA NA3 30 11 to 18 Estradiol1 NA 24 hr4

Immature s.c. INJ PND 21 NA NA3 30 11 to 18 Estradiol1 NA 24 hr4

Immature s.c. INJ PND 21 NA NA3 30 11 to 18 Estradiol1 NA 24 hr4

Immature s.c. INJ PND 21 NA NA3 11 5 to 6 Estradiol1 NA 24 hr2

Immature s.c. INJ PND 21 NA NA3 11 11 estradiol1 NA 24 hr 4 to 5

Immature s.c. INJ PND 19 NA NA366 Ethinyl estradiol 1 NA 24 hr2

OVX s.c. INJ PND 84 8 weeks 4 weeks3 10 10 E211 24 hr5

Immature p.o. ORAL PND 20 NA NA355 EE11 24 hr8

Immature p.o. ORAL PND 20 NA NA3 5+ 5+ EE11 24 hr5

Immature p.o. ORAL PND 20 NA NA3 >=5 >=5 Ethinyl estradiol 11 24 hr 4+

Immature p.o. ORAL PND 20 NA NA3 >=5 >=5 Ethinyl estradiol 11 24 hr8

Immature p.o. ORAL PND 19 NA NA3 10 10 Estradiol1 NA 24 hrs3

Immature s.c. INJ PND 20 NA NA366 Ethinyl estradiol 1 NA 24 hr3

Immature s.c. INJ PND 20 NA NA366 Ethinyl estradiol 1 NA 24 hr3

Immature s.c. INJ PND 20 NA NA366 Ethinyl estradiol 1 NA 24 hr3

Immature s.c. INJ PND 20 NA NA366 Ethinyl estradiol 1 NA 24 hr3

Immature s.c. INJ PND 20 NA NA366 Ethinyl estradiol 1 NA 24 hr3

Immature s.c. INJ PND 20 NA NA366 Ethinyl estradiol 1 NA 24 hr3

Immature s.c. INJ PND 20 NA NA366 Ethinyl estradiol 1 NA 24 hr3

Immature s.c. INJ PND 20 NA NA366 Ethinyl estradiol 1 NA 24 hr3

Immature s.c. INJ PND 20 NA NA366 Ethinyl estradiol 1 NA 24 hr3

Immature s.c. INJ PND 20 NA NA366 Ethinyl estradiol 1 NA 24 hr3

Immature s.c. INJ PND 20 NA NA366 Ethinyl estradiol 1 NA 24 hr3

Immature s.c. INJ PND 20 NA NA366 Ethinyl estradiol 1 NA 24 hr3

Immature s.c. INJ PND 20 NA NA366 Ethinyl estradiol 1 NA 24 hr3

Immature s.c. INJ PND 20 NA NA366 Ethinyl estradiol 1 NA 24 hr3
Immature s.c. INJ PND 20 NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3

Immature s.c. INJ PND 19 NA NA 3 10 10 E2 and 17?-ethinylestradiol 1 NA 24 hr 4

Immature s.c. INJ PND 20 NA NA 3 6 6 E2 1 NA 24 hr 3

Immature s.c. INJ PND 20 NA NA 3 5 to 12 8 to 12 ethinyl estradiol 1 NA 27 hr 2

Immature p.o. ORAL PND 20 – 22 NA NA 3 6 6 estradiol benzoate 1 NA 24 hr 5

Immature p.o. ORAL PND 19 NA NA 3 6 6 Estradiol 1 NA 24 hr 4

Immature p.o. ORAL PND 20 NA NA 3 6 8 to 13 Ethinyl estradiol 1 NA 24 hr 4

Immature p.o. ORAL PND 21 NA NA 3 6 to 7 6 to 7 Ethinyl estradiol 1 NA 24 hr 2

Immature p.o. ORAL PND 21 NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 5

Immature s.c. INJ PND 19 - 21NA NA 3 8 to 10 7 to 10 Estradiol 1 1 24 hr 4 to 5

Immature s.c. INJ PND 19 - 21NA NA 3 8 to 10 7 to 10 Estradiol 1 1 24 hr 4 to 5

Immature s.c. INJ PND 19 - 21NA NA 3 8 to 10 7 to 10 Estradiol 1 1 24 hr 4 to 5

Immature p.o. ORAL PND 19 NA NA 3 8 8 Ethinyl estradiol 1 1 24 hr 3

Immature p.o. ORAL PND 21 NA NA 3 7 to 9 11 17-b estradiol 1 NA 24 hr 5

OVX s.c. INJ PND 56 6 weeks 2 weeks 7 6 6 EE 1 1 24 hr 4

OVX p.o. ORAL PND 56 6 weeks 2 weeks 7 6 6 EE 1 1 24 hr 4

OVX s.c. INJ PND 56 6 weeks 2 weeks 7 6 6 EE 1 1 24 hr 4

OVX p.o. ORAL PND 56 6 weeks 2 weeks 7 6 6 EE 1 1 24 hr 4

OVX s.c. INJ PND 56 6 weeks 2 weeks 7 6 6 EE 1 1 24 hr 4

OVX p.o. ORAL PND 56 6 weeks 2 weeks 7 6 6 EE 1 1 24 hr 4

OVX s.c. INJ PND 56 6 weeks 2 weeks 7 6 6 EE 1 1 24 hr 4

OVX p.o. ORAL PND 56 6 weeks 2 weeks 7 6 6 EE 1 1 24 hr 4
OVX s.c. INJ PND 56 6 weeks 2 weeks

766 EE11 24 hr4

OVX p.o. ORAL PND 56 6 weeks 2 weeks766 EE11 24 hr4

OVX s.c. INJ PND 56 6 weeks 2 weeks766 EE11 24 hr4

OVX p.o. ORAL PND 56 6 weeks 2 weeks766 EE11 24 hr4

OVX s.c. INJ PND 56 6 weeks 2 weeks766 EE11 24 hr4

OVX p.o. ORAL PND 56 6 weeks 2 weeks766 EE11 24 hr4

OVX p.o. ORAL PND 56 6 weeks 2 weeks766 EE11 24 hr4

OVX p.o. ORAL PND 56 6 weeks 2 weeks766 EE11 24 hr4

OVX s.c. INJ PND 56 6 weeks 2 weeks766 EE11 24 hr4

OVX p.o. ORAL PND 56 6 weeks 2 weeks766 EE11 24 hr4

OVX p.o. ORAL PND 56 6 weeks 2 weeks766 EE11 24 hr4

OVX s.c. INJ PND 56 6 weeks 2 weeks766 EE11 24 hr4

OVX s.c. INJ PND 56 6 weeks 2 weeks766 EE11 24 hr4

OVX p.o. ORAL PND 56 6 weeks 2 weeks766 EE11 24 hr4

OVX s.c. INJ PND 56 6 weeks 2 weeks766 EE11 24 hr4

OVX p.o. ORAL PND 56 6 weeks 2 weeks766 EE11 24 hr4

OVX s.c. INJ PND 56 6 weeks 2 weeks766 EE11 24 hr4

OVX p.o. ORAL PND 56 6 weeks 2 weeks766 EE11 24 hr4

OVX s.c. INJ PND 56 6 weeks 2 weeks766 EE11 24 hr4

OVX p.o. ORAL PND 56 6 weeks 2 weeks766 EE11 24 hr4

OVX s.c. INJ PND 56 6 weeks 2 weeks766 Ethinyl estradiol 11 24 hr4

OVX p.o. ORAL PND 56 6 weeks 2 weeks766 Ethinyl estradiol 11 24 hr4

OVX s.c. INJ PND 56 6 weeks 2 weeks766 Ethinyl estradiol 11 24 hr4

OVX p.o. ORAL PND 56 6 weeks 2 weeks766 Ethinyl estradiol 11 24 hr4

OVX s.c. INJ PND 56 6 weeks 2 weeks766 Ethinyl estradiol 11 24 hr4

OVX s.c. INJ PND 56 6 weeks 2 weeks766 Ethinyl estradiol 11 24 hr4

OVX p.o. ORAL PND 56 6 weeks 2 weeks766 Ethinyl estradiol 11 24 hr4

OVX s.c. INJ PND 56 6 weeks 2 weeks766 Ethinyl estradiol 11 24 hr4

OVX p.o. ORAL PND 56 6 weeks 2 weeks766 Ethinyl estradiol 11 24 hr4

OVX p.o. ORAL PND 56 6 weeks 2 weeks766 EE11 24 hr4

OVX s.c. INJ PND 56 6 weeks 2 weeks766 EE11 24 hr4

OVX s.c. INJ PND 56 6 weeks 2 weeks766 EE11 24 hr4

OVX p.o. ORAL PND 56 6 weeks 2 weeks766 EE11 24 hr4

Immature p.o. ORAL PND 21 NA NA3 7 to 9 7 to 9 17-b estradiol 1 NA 24 hr5

Immature p.o. ORAL PND 21 NA NA388 17-b estradiol 1 NA 24 hr5

Immature p.o. ORAL PND 21 NA NA3 7 to 9 13 to 14 17-b estradiol 1 NA 24 hr 2 to 5
Immature p.o. ORAL PND 19 NA NA

366 ethinyl estradiol 11 24 hr3

Immature p.o. ORAL PND 18 NA NA35 5 to 7 Estradiol valerate 1 NA 24 hr2

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature s.c. INJ PND 19 NA NA366 Estradiol1 NA 24 hr3

Immature p.o. ORAL PND 20 – 22 NA NA366 estradiol benzoate 1 NA 24 hr5

Immature p.o. ORAL PND 20 – 22 NA NA366 estradiol benzoate 1 NA 24 hr5

Immature s.c. INJ PND 20 – 22 NA NA366 estradiol benzoate 1 NA 24 hr5

OVX s.c. INJ PND 68 PND 56 12 days766 Estradiol1 NA 24 hr5
MC_1 MC_2 MC_3 MC_4 MC_5 MC_6 MC_7

1 1 1 1 1 1 0

1 1 1 1 1 1 0

1 1 1 1 1 1 0

1 1 1 1 1 1 0

1 1 1 1 1 1 0

1 1 1 1 1 1 0

1 1 1 1 1 1 0

1 1 1 1 1 1 0

1 1 1 1 1 1 0

1 1 1 1 1 1 0

1 1 1 1 1 1 0

1 1 1 1 1 1 0

1 1 1 1 1 1 0

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References lacking PMID numbers:

1) NICEATM_CERI_METI

CERI, METI. 2006. Draft Report of Pre-validation and Inter-laboratory Validation For Stably Transfected Transcriptional Activa

2) NICEATM_Brady_2000

Brady AM, Moffat GJ, Hall MG, Martens FK, Martens MA, and Nair R. 2000. An Assessment of In Vivo Estrogenic Activity of Bu

3) NICEATM_Goswami_2012

Goswami P and Kalita JC. 2012. Effect of Short Term Exposure of Butylparaben on Uterine Weight of Ovariectomised C3H Alb
ted Transcriptional Activation (TA) Assay to Detect Estrogenic Activity. Ver 2006.Oct.06

o Estrogenic Activity of Butyl Benzyl Phthalate and its Principal Mammalian Metabolites. Toxic Substance Mechanisms 19: 1-24.

f Ovariectomised C3H Albino Mice. International Research Journal of Pharmacy 3 (9): 150-151.
anisms 19: 1-24.