CASRN Chemical PMID ResponseLEL_or_HDT_Dose Units MC.SumSpecies 50-28-2 Estradiol 3616 Active 0.000125 mg 6 rat 143-50-0 Chlordecone 93289 Active 6 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 109951 Active 0.000312 mg/day 6 rat 50-27-1 Estriol 174891 Active 0.002 mg/rat/day6 rat 50-28-2 Estradiol 174891 Active 0.00005 mg/rat/day6 rat 521-18-6 Dihydrotestosterone 177269 Active 0.2 mg/rat/day6 rat 50-28-2 Estradiol 564791 Active 0.00002 mg/day 6 rat 56-53-1 Diethylstilbestrol 564791 Inactive

### NA NA 6 rat 10540-29-1Tamoxifen 591813 Active 0.00025 mg/day 6 rat 10540-29-1Tamoxifen 591813 Active 0.0005 mg/day 6 rat 50-28-2 Estradiol 591813 Active 0.00002 mg/day 6 rat 10540-29-1Tamoxifen 1805462 Active 0.0005 mg/day 6 rat 50-28-2 Estradiol 1805462 Active 0.00001 mg/day 6 rat 10540-29-1Tamoxifen 1933854 Active 1 mg/kg/day 6 rat 10540-29-1Tamoxifen 1933854 Active 0.1 mg/kg/day 6 rat 10540-29-1Tamoxifen 1962598 Active 0.32 mg/kg/day 6 rat 50-28-2 Estradiol 2362436 Active 0.0001 mg/day 6 rat 17924-92-4Zearalenone 2951527 Active 0.4 mg/day 6 rat 50-28-2 Estradiol 2951527 Active 0.00033 mg/day 6 rat 50-28-2 Estradiol 3660440 Active 0.000002 mg/day 6 rat 84-16-2 Hexestrol 3660440 Active 0.000001 mg/day 6 rat 53-16-7 Estrone 3951331 Active 0.01 mg/day 6 rat 50-28-2 Estradiol 4689748 Active 0.00009 mg/day 6 rat 50-28-2 Estradiol 4725783 Active 0.0001 mg(total dose)6 rat 57-63-6 ethinyl estradiol 4725783 Active 0.00005 mg(total dose)6 rat 72-33-3 Mestranol 4725783 Active 0.0003 mg (total dose)6 rat 56-53-1 Diethylstilbestrol 5581648 Active 0.0001 mg (total dose)6 rat 789-02-6 o,p'-DDT 5772860 Active 1 mg/kg 6 rat 10540-29-1Tamoxifen 6431104 Active 0.001 mg/rat/day6 rat 10540-29-1Tamoxifen 6538611 Active 0.01 mg/kg/day 6 rat 10540-29-1Tamoxifen 7128917 Active 0.001 mg/day 6 rat 50-28-2 Estradiol 7128917 Active 0.00003 mg/day 6 rat 50-27-1 Estriol 7365751 Active NA NA 6 rat 50-28-2 Estradiol 7365751 Active NA NA 6 rat 53-16-7 Estrone 7365751 Active NA NA 6 rat 57-63-6 Ethinyl Estradiol 7365751 Active NA NA 6 rat72-33-3 Mestranol 7365751 Active NA NA 6 rat 10540-29-1Tamoxifen 7382727 Active 0.005 mg/day 6 rat 77-06-5 Gibberellic acid 7442448 Active 0.0001 mg 6 mouse 77-06-5 Gibberellic acid 7442448 Active 0.0001 mg 6 mouse 10540-29-1Tamoxifen 7470748 Active 0.001 mg/day 6 rat 57-63-6 Ethinyl estradiol 7470748 Active 0.000005 mg/day 6 rat 72-33-3 Mestranol 7470748 Active 0.00008 mg/day 6 rat 50-27-1 Estriol 8954758 Active NA NA 6 rat 50-27-1 Estriol 8954758 Active NA NA 6 rat 50-28-2 Estradiol 8954758 Active NA NA 6 rat 50-28-2 Estradiol 8954758 Active NA NA 6 rat 53-16-7 Estrone 8954758 Active NA NA 6 rat 53-16-7 Estrone 8954758 Active NA NA 6 rat 56-53-1 Diethylstilbestrol 8954758 Active NA NA 6 rat 56-53-1 Diethylstilbestrol 8954758 Active NA NA 6 rat 57-63-6 Ethinyl estradiol 8954758 Active NA NA 6 rat 57-63-6 Ethinyl estradiol 8954758 Active NA NA 6 rat 9005-65-6Polysorbate 80 9096282 Inactive

### 5000 mg/kg/day 6 rat 50-28-2 Estradiol 9192820 Active 0.000045 mg/day 6 mouse 53-16-7 Estrone 9192820 Active 0.000045 mg/day 6 mouse 10540-29-1Tamoxifen 9275080 Active 0.037152 mg/kg/day 6 rat 637-07-0 Clofibrate 9339486 Inactive

### 8 mg/kg/day 6 rat 637-07-0 Clofibrate 9339486 Inactive

### 20 mg/kg/day 6 rat 637-07-0 Clofibrate 9339486 Inactive

### 20 mg/kg/day 6 rat 637-07-0 Clofibrate 9339486 Inactive

### 200 mg/kg/day 6 rat 637-07-0 Clofibrate 9339486 Inactive

### 200 mg/kg/day 6 rat 65-85-0 Benzoic acid 9339486 Inactive

### 1 mg/kg/day 6 rat 65-85-0 Benzoic acid 9339486 Inactive

### 1 mg/kg/day 6 rat 80-05-7 Bisphenol A 9799186 Active 400 mg/kg/day 6 rat 80-05-7 Bisphenol A 9799186 Active 400 mg/kg/day 6 rat 94-26-8 Butylparaben 9875295 Active 200 mg/kg/day 6 rat 94-26-8 Butylparaben 9875295 Inactive

### 400 mg/kg/day 6 rat 94-26-8 Butylparaben 9875295 Active 400 mg/kg/day 6 rat 94-26-8 Butylparaben 9875295 Active 600 mg/kg/day 6 rat 94-26-8 Butylparaben 9875295 Active 800 mg/kg/day 6 rat 99-76-3 Methylparaben 9875295 Inactive

### 80 mg/kg/day 6 rat 99-76-3 Methylparaben 9875295 Inactive

### 800 mg/kg/day 6 rat50-28-2 17B- Estradiol 10028405 Active 0.05 mg/kg/day 6 rat 56-53-1 Diethylstilbestrol 10028405 Active 0.002 mg/kg/day 6 rat 104-40-5 p-nonylphenol 10513683 Active 75 mg/kg/day 6 rat 520-36-5 Apigenin 10720651 Active 5 mg/kg/day 6 rat 94-26-8 Butylparaben 10722885 Active 100 mg/kg/day 6 rat 57-63-6 17B- Estradiol 11020455 Active 0.1 mg/kg/day 6 rat 57-91-0 17a-estradiol 11020455 Active 0.4 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11218048 Active 0.001 mg/kg/day 6 rat 80-05-7 Bisphenol A 11258963 Active 800 mg/kg 6 rat 80-05-7 Bisphenol A 11258963 Active 200 mg/kg 6 rat 107-46-0 Hexamethyldisiloxane 11509742 Inactive

### 1200 mg/kg/day 6 rat 556-67-2 Octamethylcyclotetrasiloxane (D4) 11509742 Active 250 mg/kg/day 6 rat 556-67-2 Octamethylcyclotetrasiloxane (D4) 11509742 Active 250 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0001 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0001 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0001 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0001 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0001 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0001 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0001 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0001 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day 6 rat57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.0003 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.001 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11564613 Active 0.003 mg/kg/day 6 rat 104-40-5 p-nonylphenol 11731037 Inactive

### 2 mg/kg/day 6 rat 104-40-5 p-nonylphenol 11731037 Inactive

### 200 mg/kg/day 6 rat 104-40-5 p-nonylphenol 11731037 Active 200 mg/kg/day 6 rat 104-40-5 p-nonylphenol 11750080 Inactive

### 200 mg/kg/day 6 rat 119-61-9 Benzophenone 11750080 Inactive

### 200 mg/kg/day 6 rat 140-66-9 4-tert-octylphenol 11750080 Active 200 mg/kg/day 6 rat 1461-22-9Tributyltin chloride 11750080 Inactive

### 200 mg/kg/day 6 rat 17924-92-4Zearalenone 11750080 Active 20 mg/kg/day 6 rat 1806-26-44-n-octylphenol 11750080 Inactive

### 200 mg/kg/day 6 rat 2467-02-9Bisphenol F 11750080 Active 20 mg/kg/day 6 rat 446-72-0 Genistein 11750080 Active 20 mg/kg/day 6 rat 474-86-2 Equilin 11750080 Active 2 mg/kg/day 6 rat 50-28-2 Estradiol 11750080 Active 2 mg/kg/day 6 rat 521-18-6 Dihydrotestosterone 11750080 Active 200 mg/kg/day 6 rat 53-16-7 Estrone 11750080 Active 2 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11750080 Active 0.002 mg/kg/day 6 rat 599-64-4 P-cumylphenol 11750080 Active 200 mg/kg/day 6 rat 68-22-4 Norethindrone 11750080 Active 20 mg/kg/day 6 rat 77-40-7 Bisphenol B 11750080 Active 200 mg/kg/day 6 rat 797-63-7 Norgestrel 11750080 Active 20 mg/kg/day 6 rat 80-05-7 Bisphenol A 11750080 Active 20 mg/kg/day 6 rat84-61-7 Dicyclohexylphthalate 11750080 Inactive

### 200 mg/kg/day 6 rat 84-74-2 Dibutyl phthalate 11750080 Inactive

### 200 mg/kg/day 6 rat 302-79-4 trans-retinoic acid 11751013 Inactive

### 25 mg/kg/day 6 rat 104-51-8 n-butylbenzene 11876503 Inactive

### 2000 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 11876503 Active 0.0006 mg/kg 6 rat 51630-58-1Fenvalerate 12052007 Inactive

### 80 mg/kg/day 6 rat 52645-53-1Permethrin 12052007 Inactive

### 150 mg/kg/day 6 rat 66230-04-4Esfenvalerate 12052007 Inactive

### 20 mg/kg/day 6 rat 80-05-7 Bisphenol A 12062901 Inactive

### 1000 mg/kg/day 6 rat 56-53-1 Diethylstilbestrol 12075118 Active 0.00005 mg/kg 6 rat 104-40-5 p-nonylphenol 12128099 Active 100 mg/kg/day 6 rat 52918-63-5Deltamethrin 12202052 Inactive

### 4 mg/kg/day 6 rat 446-72-0 Genistein 12415423 Active 5 mg/kg 6 rat 446-72-0 Genistein 12415423 Active 20 mg/kg 6 rat 446-72-0 Genistein 12415423 Active 20 mg/kg 6 rat 80-05-7 Bisphenol A 12415423 Inactive

### 10 mg/kg/day 6 rat 80-05-7 Bisphenol A 12415423 Inactive

### 10 mg/kg/day 6 rat 80-05-7 Bisphenol A 12415423 Inactive

### 10 mg/kg/day 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12415423 Active 100 mg/kg 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12415423 Active 100 mg/kg 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12415423 Active 100 mg/kg 6 rat 104-40-5 p-nonylphenol 12453737 Active 200 mg/kg/day 6 rat 80-05-7 Bisphenol A 12453737 Active 200 mg/kg/day 6 rat 104-43-8 p-Dodecyl-phenol 12504345 Active 40 mg/kg/day 6 rat 131-55-5 2,2',4,4'-Tetrahydroxybenzophenone 12504345 Active 200 mg/kg/day 6 rat 1478-61-14,4'-(Hexafluoroisopropylidene)diphenol12504345 Active 8 mg/kg/day 6 rat 58-18-4 Methyltestosterone 12504345 Active 10 mg/kg/day 6 rat 80-46-6 p-(Tert-pentyl)phenol 12504345 Active 200 mg/kg/day 6 rat 26002-80-2d-phenothrin 12628315 Inactive

### 1000 mg/kg/day 6 rat 131-55-5 2,2',4,4'-Tetrahydroxybenzophenone 12765246 Active 200 mg/kg/day 6 rat 1478-61-14,4'-(Hexafluoroisopropylidene)diphenol12765246 Active 8 mg/kg/day 6 rat 80-46-6 p-(tert)-Pentyl)phenol 12765246 Active 200 mg/kg/day 6 rat 1806-26-4Ocytlphenol 12849853 Active 100 mg/kg/day 6 rat 446-72-0 Genistein 12849853 Active 100 mg/kg/day 6 rat 520-18-3 Kaempferol 12849853 Inactive

### 200 mg/kg/day 6 rat 520-36-5 Apigenin 12849853 Inactive

### 200 mg/kg/day 6 rat 80-05-7 Bisphenol A 12849853 Inactive

### 200 mg/kg/day 6 rat446-72-0 Genistein 12948896 Active 1 mg/kg/day 6 rat 446-72-0 Genistein 12948896 Active 15 mg/kg/day 6 rat 446-72-0 Genistein 12948896 Active 15 mg/kg/day 6 rat 446-72-0 Genistein 12948896 Active 15 mg/kg/day 6 rat 446-72-0 Genistein 12948896 Active 15 mg/kg/day 6 rat 446-72-0 Genistein 12948896 Active 15 mg/kg/day 6 rat 446-72-0 Genistein 12948896 Active 15 mg/kg/day 6 rat 446-72-0 Genistein 12948896 Active 15 mg/kg/day 6 rat 446-72-0 Genistein 12948896 Active 20 mg/kg/day 6 rat 446-72-0 Genistein 12948896 Active 20 mg/kg/day 6 rat 446-72-0 Genistein 12948896 Active 35 mg/kg/day 6 rat 446-72-0 Genistein 12948896 Active 60 mg/kg/day 6 rat 446-72-0 Genistein 12948896 Active 60 mg/kg/day 6 rat 446-72-0 Genistein 12948896 Active 60 mg/kg/day 6 rat 72-43-5 Methoxychlor 12948896 Active 20 mg/kg/day 6 rat 72-43-5 Methoxychlor 12948896 Active 20 mg/kg/day 6 rat 72-43-5 Methoxychlor 12948896 Active 20 mg/kg/day 6 rat 72-43-5 Methoxychlor 12948896 Active 50 mg/kg/day 6 rat 72-43-5 Methoxychlor 12948896 Active 50 mg/kg/day 6 rat 72-43-5 Methoxychlor 12948896 Active 100 mg/kg/day 6 rat 72-43-5 Methoxychlor 12948896 Active 100 mg/kg/day 6 rat 72-43-5 Methoxychlor 12948896 Active 100 mg/kg/day 6 rat 72-43-5 Methoxychlor 12948896 Active 100 mg/kg/day 6 rat 72-43-5 Methoxychlor 12948896 Active 100 mg/kg/day 6 rat 72-43-5 Methoxychlor 12948896 Active 100 mg/kg/day 6 rat 72-43-5 Methoxychlor 12948896 Active 100 mg/kg/day 6 rat 72-43-5 Methoxychlor 12948896 Active 100 mg/kg/day 6 rat 72-43-5 Methoxychlor 12948896 Active 100 mg/kg/day 6 rat 789-02-6 o,p'-DDT 12948896 Active 10 mg/kg/day6 rat 789-02-6 o,p'-DDT 12948896 Active 50 mg/kg/day6 rat 789-02-6 o,p'-DDT 12948896 Active 50 mg/kg/day 6 rat 789-02-6 o,p'-DDT 12948896 Active 50 mg/kg/day 6 rat 789-02-6 o,p'-DDT 12948896 Active 50 mg/kg/day 6 rat 789-02-6 o,p'-DDT 12948896 Active 50 mg/kg/day 6 rat 789-02-6 o,p'-DDT 12948896 Active 50 mg/kg/day 6 rat 789-02-6 o,p'-DDT 12948896 Inactive100 mg/kg/day 6 rat 789-02-6 o,p'-DDT 12948896 Active 100 mg/kg/day 6 rat 789-02-6 o,p'-DDT 12948896 Active 100 mg/kg/day 6 rat789-02-6 o,p'-DDT 12948896 Active 200 mg/kg/day 6 rat 789-02-6 o,p'-DDT 12948896 Active 200 mg/kg/day 6 rat 789-02-6 o,p'-DDT 12948896 Active 200 mg/kg/day 6 rat 789-02-6 o,p'-DDT 12948896 Active 200 mg/kg/day6 rat 80-05-7 Bisphenol A 12948896 Active 10 mg/kg/day 6 rat 80-05-7 Bisphenol A 12948896 Active 10 mg/kg/day 6 rat 80-05-7 Bisphenol A 12948896 Active 10 mg/kg/day 6 rat 80-05-7 Bisphenol A 12948896 Active 100 mg/kg/day 6 rat 80-05-7 Bisphenol A 12948896 Active 100 mg/kg/day 6 rat 80-05-7 Bisphenol A 12948896 Active 100 mg/kg/day 6 rat 80-05-7 Bisphenol A 12948896 Active 100 mg/kg/day 6 rat 80-05-7 Bisphenol A 12948896 Active 100 mg/kg/day 6 rat 80-05-7 Bisphenol A 12948896 Active 100 mg/kg/day 6 rat 80-05-7 Bisphenol A 12948896 Active 100 mg/kg/day 6 rat 80-05-7 Bisphenol A 12948896 Active 100 mg/kg/day 6 rat 80-05-7 Bisphenol A 12948896 Active 100 mg/kg/day 6 rat 80-05-7 Bisphenol A 12948896 Active 100 mg/kg/day 6 rat 80-05-7 Bisphenol A 12948896 Active 300 mg/kg/day 6 rat 80-05-7 Bisphenol A 12948896 Active 300 mg/kg/day 6 rat 80-05-7 Bisphenol A 12948896 Active 300 mg/kg/day 6 rat 80-05-7 Bisphenol A 12948896 Active 375 mg/kg/day 6 rat 80-05-7 Bisphenol A 12948896 Active 375 mg/kg/day 6 rat 80-05-7 Bisphenol A 12948896 Inactive

### 600 mg/kg/day 6 rat 80-05-7 Bisphenol A 12948896 Active 600 mg/kg/day 6 rat 80-05-7 Bisphenol A 12948896 Active 600 mg/kg/day 6 rat 80-05-7 Bisphenol A 12948896 Active 1000 mg/kg/day 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12948896 Active 5 mg/kg/day 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12948896 Active 35 mg/kg/day 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12948896 Active 35 mg/kg/day 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12948896 Active 35 mg/kg/day 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12948896 Active 35 mg/kg/day 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12948896 Active 75 mg/kg/day 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12948896 Active 75 mg/kg/day 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12948896 Active 75 mg/kg/day 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12948896 Active 75 mg/kg/day 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12948896 Active 75 mg/kg/day 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12948896 Inactive

### 80 mg/kg/day 6 rat84852-15-3Nonylphenol (mixture of branched chains)12948896 Inactive

### 80 mg/kg/day 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12948896 Active 80 mg/kg/day 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12948896 Active 80 mg/kg/day 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12948896 Active 80 mg/kg/day 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12948896 Active 80 mg/kg/day 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12948896 Active 80 mg/kg/day 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12948896 Active 80 mg/kg/day 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12948896 Active 100 mg/kg/day 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12948896 Active 100 mg/kg/day 6 rat 84852-15-3Nonylphenol (mixture of branched chains)12948896 Active 100 mg/kg/day 6 rat 53-16-7 Estrone 13173415 Active 0.0006 mg(total dose)6 rat 556-67-2 Octamethylcyclotetrasiloxane (D4) 14575643 Active 250 mg/kg/day 6 mouse 50-41-9 clomiphene citrate 14643963 Active 2 mg/kg/day 6 rat 5153-25-32-ethylhexyl-p-hydroxybenzoate 14643963 Active 200 mg/kg/day 6 rat 80-09-1 4,4'-sulfonyldiphenol 14643963 Active 20 mg/kg/day 6 rat 84-75-3 phthalic acid di-n-hexyl ester 14643963 Inactive

### 1000 mg/kg/day 6 rat 98-54-4 p-t-Butylphenol 14643963 Active 100 mg/kg/day 6 rat 104-40-5 p-nonylphenol 14981825 Active 90 mg/kg/day 6 rat 446-72-0 Genistein 15064164 Active 2.5 mg/kg/day 6 rat 446-72-0 Genistein 15064164 Active 2.5 mg/kg/day 6 rat 446-72-0 Genistein 15064164 Inactive

### 5 mg/kg/day 6 rat 446-72-0 Genistein 15064164 Active 10 mg/kg/day 6 rat 446-72-0 Genistein 15064164 Active 10 mg/kg/day 6 rat 446-72-0 Genistein 15064164 Active 15 mg/kg/day 6 rat 50-28-2 Estradiol 15064164 Active 0.0001 mg/kg/day 6 rat 50-28-2 Estradiol 15064164 Active 0.001 mg/kg/day 6 rat 50-28-2 Estradiol 15064164 Active 0.001 mg/kg/day 6 rat 56-53-1 Diethylstilbestrol 15064164 Active 0.00025 mg/kg/day 6 rat 56-53-1 Diethylstilbestrol 15064164 Active 0.00025 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 15064164 Active 0.0001 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 15064164 Active 0.0001 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 15064164 Active 0.00015 mg/kg/day 6 rat 72-43-5 Methoxychlor 15064164 Active 50 mg/kg/day 6 rat 72-43-5 Methoxychlor 15064164 Active 50 mg/kg/day 6 rat 72-43-5 Methoxychlor 15064164 Active 50 mg/kg/day 6 rat 80-05-7 Bisphenol A 15064164 Active 30 mg/kg/day 6 rat 80-05-7 Bisphenol A 15064164 Active 75 mg/kg/day 6 rat80-05-7 Bisphenol A 15064164 Active 75 mg/kg/day 6 rat 80-05-7 Bisphenol A 15064164 Active 75 mg/kg/day 6 rat 80-05-7 Bisphenol A 15064164 Active 300 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 15147785 Active 0.0002 mg/kg/day 6 rat 33089-61-1Amitraz 15350676 Inactive

### 50 mg/kg/day 6 rat 80-05-7 Bisphenol A 15456929 Active 200 mg/kg/day 6 rat 80-05-7 Bisphenol A 15456929 Active 400 mg/kg/day 6 rat 50-28-2 Estradiol 15596252 Active 0.0005 mg/kg/day 6 rat 80-05-7 Bisphenol A 15596252 Active 50 mg/kg/day 6 rat 52645-53-1Permethrin 15599112 Active 800 mg/kg/day 6 rat 120-47-8 Ethyl paraben 15697177 Active 180 mg/kg/day 6 rat 94-13-3 Propyl paraben 15697177 Active 65 mg/kg/day 6 rat 94-26-8 Butyl paraben 15697177 Active 70 mg/kg/day 6 rat 99-76-3 Methyl paraben 15697177 Active 55 mg/kg/day 6 rat 99-96-7 p-hydroxybenzoic acid 15697177 Inactive

### 150 mg/kg/day 6 rat 50-28-2 Estradiol 15763248 Active 0.01 mg/kg/day 6 rat 82640-04-8Raloxifene HCl 15961563 Active 0.5 mg/kg/day 6 rat 17924-92-4Zearalenone 17097287 Active 2 mg/kg/day 6 mouse 140-66-9 4-tert-octylphenol (OP) 17222880 Active 56 mg/kg/day 6 rat 319-85-7 hexachlorocyclohexane (HCH) 17222880 Active 3 mg/kg/day 6 rat 72-43-5 Methoxychlor (MXC) 17222880 Active 23 mg/kg/day 6 rat 789-02-6 o,p-DDT 17222880 Active 14 mg/kg/day 6 rat 6422-86-2di-2-ethylhexylterephthalate 17849488 Inactive

### 2000 mg/kg/day 6 rat 103-23-1 Di (2-ethylhexyl) adipate= Bis(2-ethylhexyl)adipate 17904329 Inactive

### 1000 mg/kg/day 6 rat 104-43-8 p-Dodecyl-phenol 17904329 Active 40 mg/kg/day 6 rat 106-46-7 p-Dichlorobenzene 17904329 Inactive

### 1000 mg/kg/day 6 rat 117-81-7 Di(2-ethylhexyl) phthalate 17904329 Inactive

### 1000 mg/kg/day 6 rat 120-47-8 Ethyl-p-hydroxybenzoate 17904329 Inactive

### 1000 mg/kg/day 6 rat 131-18-0 Di-n-pentyl phthalate 17904329 Inactive

### 1000 mg/kg/day 6 rat 131-55-5 2,2',4,4' -Tetrahydroxybenzophenone17904329 Active 229.7858739mg/kg/day 6 rat 131-56-6 2,4-Dihydroxybenzophenone 17904329 Active 100.198222mg/kg/day 6 rat 13311-84-7Flutamide 17904329 Inactive

### 1000 mg/kg/day 6 rat 135-19-3 2-Naphthol 17904329 Inactive

### 1000 mg/kg/day 6 rat 1478-61-14,4'-(Hexafluoroisopropylidene)diphenol17904329 Active 4 mg/kg/day 6 rat 149-30-4 2-Benzothiazolethiol = 2-Mercaptobenzothiazole 17904329 Inactive

### 1000 mg/kg/day 6 rat 17804-35-2Benomyl 17904329 Inactive

### 1000 mg/kg/day 6 rat 1912-24-9Atrazine 17904329 Inactive

### 1000 mg/kg/day 6 rat2425-06-1Captafol; 1,2,3,6-Tetrahydro-N-(1,1,2,2-tetrachloroethylthio)phthalimide 17904329 Inactive

### 1000 mg/kg/day 6 rat 50-28-2 17B- Estradiol 17904329 Active 0.001012062mg/kg/day 6 rat 50-41-9 Clomiphene citrate (cis and trans mixture)17904329 Active 2 mg/kg/day 6 rat 5153-25-32-Ethylhexyl-4-hydroxybenzoate 17904329 Active 200 mg/kg/day 6 rat 58-18-4 Methyltestosterone = 17a-Methyltestosterone 17904329 Active 10 mg/kg/day 6 rat 61-82-5 3-Amino-1,2,4-triazole 17904329 Inactive

### 1000 mg/kg/day 6 rat 77-47-4 Hexachlorocyclopentadiene 17904329 Inactive

### 1000 mg/kg/day 6 rat 80-09-1 4,4' -Sulfonyldiphenol 17904329 Active 20 mg/kg/day 6 rat 80-46-6 p-(tert-Pentyl) phenol = p-(tert-Amyl) phenol 17904329 Active 202.0667245mg/kg/day 6 rat 84-66-2 Diethylphthalate 17904329 Inactive

### 1000 mg/kg/day 6 rat 84-75-3 Di-n-hexyl phthalate 17904329 Inactive

### 1000 mg/kg/day 6 rat 87-86-5 Pentachlorophenol 17904329 Inactive

### 1000 mg/kg/day 6 rat 96-76-4 2,4-Di-tert-butylphenol 17904329 Inactive

### 1000 mg/kg/day 6 rat 97-77-8 Disulfiram 17904329 Inactive

### 1000 mg/kg/day 6 rat 98-54-4 p-tert-Butylphenol 17904329 Active 99.24936976mg/kg/day 6 rat 99-96-7 p-Hydroxybenzoic acid 17904329 Inactive

### 1000 mg/kg/day 6 rat 56-55-3 benz[a]anthracene 18634860 Active 1 mg/kg/day 6 rat 61-82-5 Amitrole 18779953 Inactive

### 1000 mg/kg/day 6 rat 57-63-6 ethinyl estradiol 18830443 Active 0.0001 mg/kg/day 6 rat 51630-58-1fenvalerate 18923997 Inactive

### 40 mg/kg/day 6 rat 446-72-0 Genistein 19239007 Active 100 mg/kg/day 6 rat 40487-42-1Pendimethalin 19897005 Active 300 mg/kg/day 6 rat 140-66-9 p-tert-octylphenol 20391140 Inactive

### 250 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol 20981862 Active 0.003 mg/kg/day 6 rat 50-28-2 Estradiol 21783589 Active 0.001 mg/kg/day 6 rat 82-68-8 Pentachloronitrobenzene 21783589 Inactive

### 800 mg/kg/day 6 rat 87-86-5 Pentachlorophenol 21783589 Inactive

### 10 mg/kg/day 6 rat 3380-34-5Triclosan 22062131 Active 7.5 mg/kg/day 6 rat 118-58-1 Benzyl salicylate (BzS) 22197706 Active 3.7 mg/kg/day 6 rat 1085-12-7Benzoic acid, 4-hydroxy-, heptyl ester23037998 Inactive

### 1000 mg/kg/day 6 mouse 1085-12-7Benzoic acid, 4-hydroxy-, heptyl ester23037998 Inactive

### 1000 mg/kg/day 6 mouse 114369-43-6Fenbuconazole 23037998 Inactive

### 1000 mg/kg/day 6 mouse 114369-43-6Fenbuconazole 23037998 Inactive

### 1000 mg/kg/day 6 mouse 120-47-8 Ethylparaben [NF] 23037998 Inactive

### 1000 mg/kg/day 6 mouse 120-47-8 Ethylparaben [NF] 23037998 Inactive

### 1000 mg/kg/day 6 mouse 131-55-5 2,2',4,4'-Tetrahydroxybenzophenone 23037998 Active 300 mg/kg/day 6 mouse 131-55-5 2,2',4,4'-Tetrahydroxybenzophenone 23037998 Active 1000 mg/kg/day 6 mouse131-56-6 2,4-Dihydroxybenzophenone 23037998 Active 300 mg/kg/day 6 mouse 131-56-6 2,4-Dihydroxybenzophenone 23037998 Active 1000 mg/kg/day 6 mouse 131-57-7 Oxybenzone 23037998 Inactive

### 1000 mg/kg/day 6 mouse 131-57-7 Oxybenzone 23037998 Inactive

### 1000 mg/kg/day 6 mouse 2440-22-4Drometrizole 23037998 Inactive

### 1000 mg/kg/day 6 mouse 2440-22-4Drometrizole 23037998 Inactive

### 1000 mg/kg/day 6 mouse 446-72-0 Genistein 23037998 Active 200 mg/kg/day 6 mouse 486-66-8 Daidzein 23037998 Active 600 mg/kg/day 6 mouse 500-38-9 Nordihydroguaiaretic acid 23037998 Inactive

### 1000 mg/kg/day 6 mouse 500-38-9 Nordihydroguaiaretic acid 23037998 Inactive

### 1000 mg/kg/day 6 mouse 50-55-5 Reserpine 23037998 Inactive

### 3 mg/kg/day 6 mouse 50-55-5 Reserpine 23037998 Active 3 mg/kg/day 6 mouse 51-24-1 Tiratricol 23037998 Active 1000 mg/kg/day 6 mouse 51-24-1 Tiratricol 23037998 Active 1000 mg/kg/day 6 mouse 520-18-3 Kaempferol 23037998 Inactive

### 1000 mg/kg/day 6 mouse 520-18-3 Kaempferol 23037998 Inactive

### 1000 mg/kg/day 6 mouse 53-70-3 Dibenz[a,h]anthracene 23037998 Inactive

### 300 mg/kg/day 6 mouse 53-70-3 Dibenz[a,h]anthracene 23037998 Inactive

### 300 mg/kg/day 6 mouse 56-55-3 Benz(a)anthracene 23037998 Inactive

### 300 mg/kg/day 6 mouse 56-55-3 Benz(a)anthracene 23037998 Inactive

### 300 mg/kg/day 6 mouse 77-09-8 Phenolphthalein 23037998 Inactive

### 1000 mg/kg/day 6 mouse 77-09-8 Phenolphthalein 23037998 Inactive

### 1000 mg/kg/day 6 mouse 79-94-7 2,2',6,6'-Tetrabromobisphenol A 23037998 Inactive

### 1000 mg/kg/day 6 mouse 79-94-7 2,2',6,6'-Tetrabromobisphenol A 23037998 Inactive

### 1000 mg/kg/day 6 mouse 80-05-7 Bisphenol A 23037998 Active 100 mg/kg/day 6 mouse 81131-70-6Pravastatin sodium 23037998 Inactive

### 1000 mg/kg/day 6 mouse 81131-70-6Pravastatin sodium 23037998 Inactive

### 1000 mg/kg/day 6 mouse 94-13-3 Propylparaben 23037998 Inactive

### 1000 mg/kg/day 6 mouse 94-13-3 Propylparaben 23037998 Inactive

### 1000 mg/kg/day 6 mouse 94-26-8 Butylparaben 23037998 Inactive

### 1000 mg/kg/day 6 mouse 94-26-8 Butylparaben 23037998 Active 1000 mg/kg/day 6 mouse 99-65-0 1,3-Dinitrobenzene 23037998 Inactive

### 10 mg/kg/day 6 mouse 99-65-0 1,3-Dinitrobenzene 23037998 Inactive

### 30 mg/kg/day 6 mouse 50-28-2 17B- Estradiol 23220609 Active 0.005 mg/kg/day 6 rat 50-28-2 17B- Estradiol 23220609 Active 0.4 mg/kg/day 6 rat 94-18-8 Benzylparaben 23220609 Active 0.16 mg/kg/day 6 rat57-63-6 ethinyl estradiol 24708211 Active 0.0003 mg/kg 6 rat 10605-21-7Carbendazim 24863245 Inactive

### 400 mg/kg/day 6 rat 103-23-1 di(2-Ethylhexyl)adipate NICEATM_CERI_METIInactive

### 1000 mg/kg/day 6 rat 104-40-5 p-nonylphenol NICEATM_CERI_METIInactive

### 200 mg/kg/day 6 rat 104-43-8 p -Dodecyl-phenol NICEATM_CERI_METIActive 40 mg/kg/day 6 rat 117-81-7 di(2-Ethylhexyl)phthalate NICEATM_CERI_METIInactive

### 1000 mg/kg/day 6 rat 119-61-9 Benzophenone NICEATM_CERI_METIInactive

### 200 mg/kg/day 6 rat 119-61-9 Benzophenone NICEATM_CERI_METIActive 500 mg/kg/day 6 rat 131-55-5 2,2',4,4'-Tetrahydroxybenzophenone NICEATM_CERI_METIActive 200 mg/kg/day 6 rat 140-66-9 4-tert -Octylphenol NICEATM_CERI_METIActive 200 mg/kg/day 6 rat 1461-22-9Tributyltin chloride NICEATM_CERI_METIInactive

### 200 mg/kg/day 6 rat 1478-61-14,4'-(Hexafluoroisopropylidene)diphenolNICEATM_CERI_METIActive 4 mg/kg/day 6 rat 17924-92-4Zearalenone NICEATM_CERI_METIActive 2 mg/kg/day 6 rat 1806-26-44-n-octylphenol NICEATM_CERI_METIInactive

### 200 mg/kg/day 6 rat 446-72-0 Genistein NICEATM_CERI_METIActive 20 mg/kg/day 6 rat 474-86-2 Equilin NICEATM_CERI_METIActive 2 mg/kg/day 6 rat 486-66-8 Daidzein NICEATM_CERI_METIInactive

### 200 mg/kg/day 6 rat 521-18-6 5a-dihydrotestosterone NICEATM_CERI_METIActive 20 mg/kg/day 6 rat 53-16-7 Estrone NICEATM_CERI_METIActive 2 mg/kg/day 6 rat 57-63-6 Ethinyl estradiol NICEATM_CERI_METIActive 0.0002 mg/kg/day 6 rat 57-91-0 17a-estradiol NICEATM_CERI_METIActive 2 mg/kg/day 6 rat 58-18-4 17a-methyl testosterone NICEATM_CERI_METIActive 10 mg/kg/day 6 rat 599-64-4 p-cumylphenol NICEATM_CERI_METIActive 20 mg/kg/day 6 rat 68-22-4 Norethindrone NICEATM_CERI_METIActive 2 mg/kg/day 6 rat 72-43-5 Methoxychlor NICEATM_CERI_METIInactive

### 200 mg/kg/day 6 rat 77-40-7 Bisphenol B NICEATM_CERI_METIActive 20 mg/kg/day6 rat 80-05-7 Bisphenol A NICEATM_CERI_METIActive 2 mg/kg/day 6 rat 80-46-6 p -(tert- Pentyl)phenol NICEATM_CERI_METIActive 200 mg/kg/day 6 rat 84-61-7 Dicyclohexyl phthalate NICEATM_CERI_METIInactive

### 1000 mg/kg/day 6 rat 84-66-2 Diethyl phthalate NICEATM_CERI_METIInactive

### 2000 mg/kg/day 6 rat 84-74-2 di-n -Butyl phthalate NICEATM_CERI_METIInactive

### 1000 mg/kg/day 6 rat 131-70-4 monobutyl phthalate NICEATM_Brady_2000Inactive

### 1000 mg/kg/day 6 rat 85-68-7 butyl benzyl phthalate NICEATM_Brady_2000Inactive

### 2240 mg/kg/day 6 rat 85-68-7 butyl benzyl phthalate NICEATM_Brady_2000Inactive

### 5000 mg/kg/day 6 rat 94-26-8 Butylparaben NICEATM_Goswami_2012 Active 50 mg/kg/day 6 mouseType Admin.Route INJorORALFirst.Dose.Age

If.OVX..age.at.OVX

Elapsed.time.between.OVX.and.RX

Duration.days

#.of.animals.in.estrogen.control.group

#.of.animals.in.RX.group

Reference.Estrogen

Is.there.a.Vehicle.RX.control.

Indicated.that.Diet.is.low.PE.

necropsy.time.after.last.dose

#.of.doses.used OVX s.c. INJ PND 70~8 weeks2 weeks3 12 12 Estradiol1 NA 24 hr 2 Immature s.c. INJ PND 21NA NA 3 5 5 Estradiol1 NA 24 hr 4 Immature p.o. ORALPND 21NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 4 Immature s.c. INJ PND 21NA NA 3 >=5 >=5 Estradiol1 NA 24 hr 4 Immature s.c. INJ PND 21NA NA 3 >=5 >=5 Estradiol1 NA 24 hr 4 Immature s.c. INJ PND 20 - 23 NA NA 3 5 5 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 21NA NA 3 5 5 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 21NA NA 3 5 5 Estradiol1 NA 24 hr 4 Immature p.o. ORALPND 21NA NA 3 8 8 E2 (s.c.)1 NA 24 hr 5 Immature s.c. INJ PND 21NA NA 3 8 8 E2 (s.c.)1 NA 24 hr 4 Immature s.c. INJ PND 21NA NA 3 8 8 E2 (s.c.)1 NA 24 hr 4 Immature s.c. INJ PND 20 - 23 NA NA 3 5 5 Estradiol1 NA 24 hr 6

Immature s.c. INJ PND 20 - 23 NA NA 3 5 5 Estradiol1 NA 24 hr 5 Immature s.c. INJ PND 21NA NA 4 5 5 Estradiol1 NA 24 hr 2 Immature s.c. INJ PND 19 - 21 NA NA 4 5 5 Estradiol benzoate 1 NA 24 hr 4 Immature p.o. ORALPND 20NA NA 3 10 10 Estradiol1 NA 24 hr 5 Immature s.c. INJ PND 22NA NA 3 10 10 Estradiol1 NA 24 hr 4 Immature p.o. ORALPND 19NA NA 3 5 to 109 to 10Estradiol1 NA 24 hrs13 Immature p.o. ORALPND 19NA NA 3 5 to 109 to 10Estradiol1 NA 24 hrs13 Immature s.c. INJ PND 21NA NA 3 6 to 86 to 8Estradiol1 NA 24 hr 4 Immature s.c. INJ PND 21NA NA 3 6 to 106 to 8Estradiol1 NA 24 hr 4 Immature s.c. INJ PND 20NA NA 3 7 7 Estrone1 NA 24 hr 3 Immature s.c. INJ PND 21NA NA 3 5 5 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19 - 21 NA NA 3 5 5 Estradiol1 NA 24 hr 5 Immature s.c. INJ PND 19 - 21 NA NA 3 5 5 Ethinyl estradiol 1 NA 24 hr 4 Immature s.c. INJ PND 19 - 21 NA NA 3 5 5 Ethinyl estradiol 1 NA 24 hr 3 Immature p.o. ORALPND 21NA NA 3 18-2418-24Diethylstilbestrol 1 NA 24 hr 3 Immature i.p. INJ PND 19NA NA 3 6 6 Estradiol1 NA 18 hr 4 Immature s.c. INJ PND 19 - 20 NA NA 3 24 6 Estradiol1 NA 24 hr 4 Immature p.o. ORALPND 18NA NA 3 5 5 Estradiol benzoate 1 NA 24 hr 4 Immature s.c. INJ PND 22NA NA 3 8 8 Estradiol1 NA 24 hr 4 Immature s.c. INJ PND 22NA NA 3 8 8 Estradiol1 NA 24 hr 4 Immature p.o. ORALPND 21NA NA 3 8 to 108 to 10Estrone1 NA 24 hr 3 Immature p.o. ORALPND 21NA NA 3 8 to 108 to 10Estrone1 NA 24 hr 3 Immature p.o. ORALPND 21NA NA 3 8 to 108 to 10Estrone1 NA 24 hr 3 Immature p.o. ORALPND 21NA NA 3 8 to 108 to 10Estrone1 NA 24 hr 3Immature p.o. ORALPND 21NA NA 3 8 to 108 to 10Estrone1 NA 24 hr 3 Immature s.c. INJ PND 19 - 20 NA NA 3 6 6 Estradiol1 NA 24 hr 6 OVX s.c. INJ PND 70PND 562 weeks5 7 7 Estradiol1 NA 24 hr 2 OVX s.c. INJ PND 110PND 566 weeks5 7 7 Estradiol1 NA 24 hr 2 Immature s.c. INJ PND 19NA NA 3 >7 >7 Estradiol benzoate 1 NA 24 hr 5 Immature s.c. INJ PND 19NA NA 3 >7 >7 Estradiol benzoate 1 NA 24 hr 5 Immature s.c. INJ PND 19NA NA 3 >7 >7 Estradiol benzoate 1 NA 24 hr 5 Immature s.c. INJ PND 19NA NA 3 10 10 ethinylestradiol 1 NA 24 hr 3 Immature p.o. ORALPND 19NA NA 3 10 10 ethinylestradiol 1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 10 10 ethinylestradiol 1 NA 24 hr 3 Immature p.o. ORALPND 19NA NA 3 10 10 ethinylestradiol 1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 10 10 ethinylestradiol 1 NA 24 hr 3 Immature p.o. ORALPND 19NA NA 3 10 10 ethinylestradiol 1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 10 10 ethinylestradiol 1 NA 24 hr 3 Immature p.o. ORALPND 19NA NA 3 10 10 ethinylestradiol 1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 10 10 ethinylestradiol 1 NA 24 hr 3 Immature p.o. ORALPND 19NA NA 3 10 10 ethinylestradiol 1 NA 24 hr 3 Immature p.o. ORALPND 21NA NA 3 6 6 Estradiol benzoate 1 NA 24 hr 5 OVX i.p. INJ PND 42NA ?4 Days3 6 to 86 to 8Estradiol1 NA 18 hr 4 OVX i.p. INJ PND 42NA ?4 Days3 6 to 86 to 8Estrone1 NA 18 hr 4 Immature p.o. ORALPND 21NA NA 3 5 5 Estradiol1 NA 24 hr 6 Immature p.o. ORALPND 21 - 22 NA NA 3 5 10 E2 1 NA 24 hr 4 Immature p.o. ORALPND 21 - 22 NA NA 3 3 5 E2 1 NA 24 hr 2 Immature p.o. ORALPND 21 - 22 NA NA 3 5 5 E2 1 NA 24 hr 2 Immature p.o. ORALPND 21 - 22 NA NA 3 5 5 to 10E2 1 NA 24 hr 4 OVX p.o. ORALPND 637 wk 2 wk 3 7 6 to 7E2 1 NA 24 hr 2 Immature s.c. INJ PND 21 - 22 NA NA 3 5 5 to 10E2 or Estradiol benzoate 1 NA 24 hr 3 Immature s.c. INJ PND 21 - 22 NA NA 3 5 5 to 10E2 or Estradiol benzoate 1 NA 24 hr 2 Immature s.c. INJ PND 21NA NA 3 5 7 DES 1 NA 24 hr 2 to 3 Immature p.o. ORALPND 21NA NA 3 5 7 DES 1 NA 24 hr 2 to 3 Immature s.c. INJ PND 21 - 22 NA NA 3 5 5 17b-estradiol 1 NA 24 hr 3 to 5 Immature p.o. ORALPND 21 - 22 NA NA 3 5 5 17b-estradiol 1 NA 24 hr 3 to 5 Immature s.c. INJ PND 21 - 22 NA NA 3 5 5 17b-estradiol 1 NA 24 hr 3 to 5 Immature s.c. INJ PND 21 - 22 NA NA 3 5 5 17b-estradiol 1 NA 24 hr 3 to 5 OVX s.c. INJ PND 56 - 70 6 - 8 weeks old

2 weeks3 5 5 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 21 - 22 NA NA 3 5 5 17b-estradiol 1 NA 24 hr 3 to 5 Immature p.o. ORALPND 21 - 22 NA NA 3 5 5 17b-estradiol 1 NA 24 hr 3 to 5Immature s.c. INJ PND 21NA NA 3 10 10 E2, DES1 NA 24 hr 2+ Immature s.c. INJ PND 21NA NA 3 10 10 E2, DES1 NA 24 hr >2 Immature p.o. ORALPND 21 - 22 NA NA 3 5 5 E2 (s.c.)1 NA 24 hr 4 OVX p.o. ORALPND 21 - 23 NA NA 7 8 8 Ethinyl estradiol 1 NA 24 hr 5 Immature s.c. INJ PND 19 - 21 NA NA 3 10 10 Estradiol benzoate 1 NA 24 hr 3 Immature p.o. ORALPND 22 - 23 NA NA 3 NA 5 to 25E2 1 NA 24 hr 5+ Immature p.o. ORALPND 22 - 23 NA NA 3 NA 5 to 25E2 1 NA 24 hr 5+ Immature s.c. INJ PND 21NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 4 Immature s.c. INJ PND 21 - 22 NA NA 3 10 10 E2 1 NA 24 hr 7 Immature p.o. ORALPND 21 - 22 NA NA 3 10 10 Ethinyl estradiol 1 NA 24 hr 8 Immature p.o. ORALPND 18NA NA 4 12 12 Estradiol1 NA 18-24 hr2 to 6 Immature p.o. ORALPND 21NA NA 4 12 12 Estradiol1 NA 18-24 hr2 to 6 Immature p.o. ORALPND 18NA NA 4 12 12 Estradiol1 NA 18-24 hr2 to 6 Immature s.c. INJ PND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature s.c. INJ PND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature s.c. INJ PND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 OVX s.c. INJ Adult 6 weeks14 - 28 days 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 OVX s.c. INJ Adult 6 weeks14 - 28 days 7 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 OVX s.c. INJ Adult 6 weeks14 - 28 days 7 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 OVX s.c. INJ Adult 6 weeks14 - 28 days 7 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 OVX s.c. INJ Adult 6 weeks14 - 28 days 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature s.c. INJ PND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature s.c. INJ PND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature s.c. INJ PND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature s.c. INJ PND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature s.c. INJ PND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature s.c. INJ PND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature s.c. INJ PND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature s.c. INJ PND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature s.c. INJ PND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature p.o. ORALPND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature p.o. ORALPND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature p.o. ORALPND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature p.o. ORALPND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 OVX s.c. INJ Adult 6 weeks14 - 28 days 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 OVX s.c. INJ Adult 6 weeks14 - 28 days 7 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 OVX s.c. INJ Adult 6 weeks14 - 28 days 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 OVX s.c. INJ Adult 6 weeks14 - 28 days 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5OVX s.c. INJ Adult 6 weeks14 - 28 days 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 OVX s.c. INJ Adult 6 weeks14 - 28 days 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 OVX s.c. INJ Adult 6 weeks14 - 28 days 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature p.o. ORALPND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature p.o. ORALPND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature p.o. ORALPND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature p.o. ORALPND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature p.o. ORALPND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature p.o. ORALPND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature p.o. ORALPND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature p.o. ORALPND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature p.o. ORALPND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature p.o. ORALPND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature p.o. ORALPND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 OVX s.c. INJ Adult 6 weeks14 - 28 days 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature p.o. ORALPND 18NA NA 3 6 to 106 to 10Ethinyl estradiol 1 NA 24 hr 5 Immature s.c. INJ PND 21NA NA 3 5 5 Estradiol1 NA 24 hr 3 OVX s.c. INJ PND 636 weeks3 weeks3 5 5 Estradiol1 NA 24 hrs5 Immature s.c. INJ PND 21NA NA 3 5 5 Estradiol1 NA 24 hr 2 Immature s.c. INJ PND 20 - 22 NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 20 - 22 NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 20 - 22 NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 20 - 22 NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 20 - 22 NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 20 - 22 NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 20 - 22 NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 20 - 22 NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 20 - 22 NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 20 - 22 NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 20 - 22 NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 20 - 22 NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 20 - 22 NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 20 - 22 NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 20 - 22 NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 20 - 22 NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 20 - 22 NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 20 - 22 NA NA 3 6 6 Estradiol1 NA 24 hr 3Immature s.c. INJ PND 20 - 22 NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 20 - 22 NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 5 5 Ethinyl estradiol 1 NA 24 hr 2 Immature s.c. INJ PND 19NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 4 Immature s.c. INJ PND 19NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 1 OVX p.o. ORALPND 566 wk 2 wk 3 6 6 Ethynyl estradiol and Methoxychlor 1 NA 24 hr 3 OVX p.o. ORALPND 566 wk 2 wk 3 6 6 Ethynyl estradiol and Methoxychlor 1 NA 24 hr 3 OVX p.o. ORALPND 566 wk 2 wk 3 6 6 Ethynyl estradiol and Methoxychlor 1 NA 24 hr 3 Immature s.c. INJ PND 18NA NA 3 5 5 E2 1 1 24 hr 1 Immature s.c. INJ PND 20 - 21 NA NA 3 NA at least 10NA 1 NA 24 hr 8 Immature s.c. INJ PND 20NA NA 3 10 10 DES 1 NA 24 hr 5 Immature p.o. ORALPND 20 - 22 NA NA 3 10 9 to 10Estradiol hexahydrobenzoate 1 NA 24 hr 2 Immature s.c. INJ PND 20NA NA 3 6 6 EE 1 1 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 EE 1 1 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 EE 1 1 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 1 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 1 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 1 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 1 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 1 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 1 24 hr 3 Immature s.c. INJ PND 21NA NA 3 5 5 Estradiol1 NA 24 hr 4 Immature s.c. INJ PND 21NA NA 3 5 5 Estradiol1 NA 24 hr 4 Immature s.c. INJ PND 19

- - 3 6 6 E2 1 NA 24 hrs3 Immature s.c. INJ PND 19

- - 3 6 6 E2 1 NA 24 hrs3 Immature s.c. INJ PND 19

- - 3 6 6 E2 1 NA 24 hrs3 Immature s.c. INJ PND 19

- - 3 6 6 E2 1 NA 24 hrs3 Immature s.c. INJ PND 19

- - 3 6 6 E2 1 NA 24 hrs3 Immature p.o. ORALPND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 ethynyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 ethynyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 ethynyl estradiol 1 NA 24 hr 3 Immature p.o. ORALPND 22NA NA 4 10 8 or 10Estradiol1 NA 24 hr 4 Immature p.o. ORALPND 22NA NA 4 10 8 or 10Estradiol1 NA 24 hr 4 Immature p.o. ORALPND 22NA NA 4 10 8 to 10Estradiol1 NA 24 hr 4 Immature p.o. ORALPND 22NA NA 4 10 8 to 10Estradiol1 NA 24 hr 4 Immature p.o. ORALPND 22NA NA 4 10 8 or 10Estradiol1 NA 24 hr 4Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 84 6 weeks14 - 28 days

3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 84 6 weeks14 - 28 days

3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 84 6 weeks14 - 28 days

7 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 84 6 weeks14 - 28 days

7 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature p.o. ORALPND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature p.o. ORALPND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 84 6 weeks14 - 28 days

3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature p.o. ORALPND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature p.o. ORALPND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX p.o. ORALPND 56 - 84 6 weeks14 - 28 days

7 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature p.o. ORALPND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature p.o. ORALPND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature p.o. ORALPND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature p.o. ORALPND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX p.o. ORALPND 56 - 84 6 weeks14 - 28 days

7 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 84 6 weeks14 - 28 days

3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 84 6 weeks14 - 28 days

3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 84 6 weeks14 - 28 days

3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 84 6 weeks14 - 28 days

7 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 84 6 weeks14 - 28 days

7 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature p.o. ORALPND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature p.o. ORALPND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature p.o. ORALPND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature p.o. ORALPND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 84 6 weeks14 - 28 days

3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 84 6 weeks14 - 28 days

7 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX p.o. ORALPND 56 - 84 6 weeks14 - 28 days

7 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 84 6 weeks14 - 28 days

3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 84 6 weeks14 - 28 days

7 6 6 Ethinyl estradiol 1 NA 24 hr >3Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 84 6 weeks14 - 28 days

3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 84 6 weeks14 - 28 days

3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 84 6 weeks14 - 28 days

3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 84 6 weeks14 - 28 days

3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 84 6 weeks14 - 28 days

3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 84 6 weeks14 - 28 days

3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 85 6 weeks14 - 28 days

7 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 86 6 weeks14 - 28 days

7 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature p.o. ORALPND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature p.o. ORALPND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX p.o. ORALPND 56 - 87 6 weeks14 - 28 days

7 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature p.o. ORALPND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature p.o. ORALPND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 86 6 weeks14 - 28 days

3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 89 6 weeks14 - 28 days

7 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 90 6 weeks14 - 28 days

7 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature p.o. ORALPND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature p.o. ORALPND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature p.o. ORALPND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature p.o. ORALPND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX p.o. ORALPND 56 - 91 6 weeks14 - 28 days

7 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3OVX s.c. INJ PND 56 - 85 6 weeks14 - 28 days

3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 84 6 weeks14 - 28 days

3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 18NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 87 6 weeks14 - 28 days

3 6 6 Ethinyl estradiol 1 NA 24 hr >3 OVX s.c. INJ PND 56 - 88 6 weeks14 - 28 days

3 6 6 Ethinyl estradiol 1 NA 24 hr >3 Immature s.c. INJ PND 22 - 23 NA NA 3 16 to 2016 to 20Estrone1 NA 24 hr 3 OVX p.o. ORALPND 63 - 70 PND 42-4914 days3 5 5 Estradiol1 NA 24 hr 7 Immature s.c. INJ PND 20NA NA 3 6 6 Ethynyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethynyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethynyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethynyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethynyl estradiol 1 NA 24 hr 3 Immature p.o. ORALPND 21NA NA 3 10 10 Estradiol benzoate 1 NA 24 hr 3 Immature s.c. INJ PND 19 - 20 NA NA 3 8 8 Ethinyl estradiol 1 NA 24 hr 4 Immature s.c. INJ PND 19 - 20 NA NA 3 8 8 Ethinyl estradiol 1 NA 24 hr 5 Immature s.c. INJ PND 19 - 20 NA NA 3 8 8 Ethinyl estradiol 1 NA 24 hr 2 Immature s.c. INJ PND 19 - 20 NA NA 3 8 8 Ethinyl estradiol 1 NA 24 hr 2 Immature s.c. INJ PND 19 - 20 NA NA 3 8 8 Ethinyl estradiol 1 NA 24 hr 2 Immature s.c. INJ PND 19 - 20 NA NA 3 12 12 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 19 - 20 NA NA 3 8 8 Ethinyl estradiol 1 NA 24 hr 2 Immature s.c. INJ PND 19 - 20 NA NA 3 8 8 Ethinyl estradiol 1 NA 24 hr 2 Immature s.c. INJ PND 19 - 20 NA NA 3 8 8 Ethinyl estradiol 1 NA 24 hr 2 Immature s.c. INJ PND 19 - 20 NA NA 3 8 8 Ethinyl estradiol 1 NA 24 hr 2 Immature s.c. INJ PND 19 - 20 NA NA 3 8 8 Ethinyl estradiol 1 NA 24 hr 2 Immature s.c. INJ PND 19 - 20 NA NA 3 8 8 Ethinyl estradiol 1 NA 24 hr 2 Immature s.c. INJ PND 19 - 20 NA NA 3 8 8 Ethinyl estradiol 1 NA 24 hr 2 Immature s.c. INJ PND 19 - 20 NA NA 3 8 8 Ethinyl estradiol 1 NA 24 hr 2 Immature s.c. INJ PND 19 - 20 NA NA 3 8 8 Ethinyl estradiol 1 NA 24 hr 2 Immature s.c. INJ PND 19 - 20 NA NA 3 8 8 Ethinyl estradiol 1 NA 24 hr 2 Immature s.c. INJ PND 19 - 20 NA NA 3 8 8 Ethinyl estradiol 1 NA 24 hr 2 Immature s.c. INJ PND 19 - 20 NA NA 3 8 8 Ethinyl estradiol 1 NA 24 hr 4 Immature s.c. INJ PND 19 - 20 NA NA 3 8 8 Ethinyl estradiol 1 NA 24 hr 2Immature s.c. INJ PND 19 - 20 NA NA 3 8 8 Ethinyl estradiol 1 NA 24 hr 2 Immature s.c. INJ PND 19 - 20 NA NA 3 8 8 Ethinyl estradiol 1 NA 24 hr 2 Immature s.c. INJ PND 19 - 20 NA NA 3 12 12 Ethinyl estradiol 1 NA 24 hr 3 Immature p.o. ORALPND 21NA NA 3 5 to 95 to 9Ethinyl estradiol 1 NA 24 hr 3 Immature i.p. INJ PND 21NA NA 3 NA 6 None 1 NA 24 hr 2 Immature p.o. ORALPND 19 - 20 NA NA 3 5 to 105 to 1017-b estradiol 1 NA 4, 24 hr8 Immature p.o. ORALPND 19 - 20 NA NA 3 5 to 105 to 1017-b estradiol 1 NA 4, 24 hr8 OVX s.c. INJ PND 848 Weeks4 weeks3 5 5 Estradiol1 1 24 hr 2 OVX s.c. INJ PND 848 Weeks4 weeks3 5 5 Estradiol1 1 24 hr 3 Immature s.c. INJ PND 19NA NA 3 8 to 128 to 12Estradiol1 NA 24 hr 5 Immature s.c. INJ PND 21NA NA 3 30 11 to 18Estradiol1 NA 24 hr 4 Immature s.c. INJ PND 21NA NA 3 30 11 to 18Estradiol1 NA 24 hr 4 Immature s.c. INJ PND 21NA NA 3 30 11 to 18Estradiol1 NA 24 hr 4 Immature s.c. INJ PND 21NA NA 3 30 11 to 18Estradiol1 NA 24 hr 4 Immature s.c. INJ PND 21NA NA 3 11 5 to 6Estradiol1 NA 24 hr 2 Immature s.c. INJ PND 21NA NA 3 11 11 estradiol1 NA 24 hr 4 to 5 Immature s.c. INJ PND 19NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 2 OVX s.c. INJ PND 848 weeks4 weeks3 10 10 E2 1 1 24 hr 5 Immature p.o. ORALPND 20NA NA 3 5 5 EE 1 1 24 hr 8 Immature p.o. ORALPND 20NA NA 3 5+ 5+ EE 1 1 24 hr 5 Immature p.o. ORALPND 20NA NA 3 >=5 >=5 Ethinyl estradiol 1 1 24 hr 4+ Immature p.o. ORALPND 20NA NA 3 >=5 >=5 Ethinyl estradiol 1 1 24 hr 8 Immature p.o. ORALPND 19NA NA 3 10 10 Estradiol1 NA 24 hrs3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 10 10 E2 and 17?-ethinylestradiol 1 NA 24 hr 4 Immature s.c. INJ PND 20NA NA 3 6 6 E2 1 NA 24 hr 3 Immature s.c. INJ PND 20NA NA 3 5 to 128 to 12ethinyl estradiol 1 NA 27 hr 2 Immature p.o. ORALPND 20 – 22 NA NA 3 6 6 estradiol benzoate 1 NA 24 hr 5 Immature p.o. ORALPND 19NA NA 3 6 6 Estradiol1 NA 24 hr 4 Immature p.o. ORALPND 20NA NA 3 6 8 to 13Ethinyl estradiol 1 NA 24 hr 4 Immature p.o. ORALPND 21NA NA 3 6 to 76 to 7Ethinyl estradiol 1 NA 24 hr 2 Immature p.o. ORALPND 21NA NA 3 6 6 Ethinyl estradiol 1 NA 24 hr 5 Immature s.c. INJ PND 19 - 21 NA NA 3 8 to 107 to 10Estradiol1 1 24 hr 4 to 5 Immature s.c. INJ PND 19 - 21 NA NA 3 8 to 107 to 10Estradiol1 1 24 hr 4 to 5 Immature s.c. INJ PND 19 - 21 NA NA 3 8 to 107 to 10Estradiol1 1 24 hr 4 to 5 Immature p.o. ORALPND 19NA NA 3 8 8 Ethinyl estradiol 1 1 24 hr 3 Immature p.o. ORALPND 21NA NA 3 7 to 911 17-b estradiol 1 NA 24 hr 5 OVX s.c. INJ PND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX p.o. ORALPND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX s.c. INJ PND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX p.o. ORALPND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX s.c. INJ PND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX p.o. ORALPND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX s.c. INJ PND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX p.o. ORALPND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4OVX s.c. INJ PND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX p.o. ORALPND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX s.c. INJ PND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX p.o. ORALPND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX s.c. INJ PND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX p.o. ORALPND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX p.o. ORALPND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX p.o. ORALPND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX s.c. INJ PND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX p.o. ORALPND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX p.o. ORALPND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX s.c. INJ PND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX s.c. INJ PND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX p.o. ORALPND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX s.c. INJ PND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX p.o. ORALPND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX s.c. INJ PND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX p.o. ORALPND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX s.c. INJ PND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX p.o. ORALPND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX s.c. INJ PND 566 weeks2 weeks7 6 6 Ethinyl estradiol 1 1 24 hr 4 OVX p.o. ORALPND 566 weeks2 weeks7 6 6 Ethinyl estradiol 1 1 24 hr 4 OVX s.c. INJ PND 566 weeks2 weeks7 6 6 Ethinyl estradiol 1 1 24 hr 4 OVX p.o. ORALPND 566 weeks2 weeks7 6 6 Ethinyl estradiol 1 1 24 hr 4 OVX s.c. INJ PND 566 weeks2 weeks7 6 6 Ethinyl estradiol 1 1 24 hr 4 OVX s.c. INJ PND 566 weeks2 weeks7 6 6 Ethinyl estradiol 1 1 24 hr 4 OVX p.o. ORALPND 566 weeks2 weeks7 6 6 Ethinyl estradiol 1 1 24 hr 4 OVX s.c. INJ PND 566 weeks2 weeks7 6 6 Ethinyl estradiol 1 1 24 hr 4 OVX p.o. ORALPND 566 weeks2 weeks7 6 6 Ethinyl estradiol 1 1 24 hr 4 OVX p.o. ORALPND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX s.c. INJ PND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX s.c. INJ PND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 OVX p.o. ORALPND 566 weeks2 weeks7 6 6 EE 1 1 24 hr 4 Immature p.o. ORALPND 21NA NA 3 7 to 97 to 917-b estradiol 1 NA 24 hr 5 Immature p.o. ORALPND 21NA NA 3 8 8 17-b estradiol 1 NA 24 hr 5 Immature p.o. ORALPND 21NA NA 3 7 to 913 to 1417-b estradiol 1 NA 24 hr 2 to 5Immature p.o. ORALPND 19NA NA 3 6 6 ethinyl estradiol 1 1 24 hr 3 Immature p.o. ORALPND 18NA NA 3 5 5 to 7Estradiol valerate 1 NA 24 hr 2 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature s.c. INJ PND 19NA NA 3 6 6 Estradiol1 NA 24 hr 3 Immature p.o. ORALPND 20 – 22 NA NA 3 6 6 estradiol benzoate 1 NA 24 hr 5 Immature p.o. ORALPND 20 – 22 NA NA 3 6 6 estradiol benzoate 1 NA 24 hr 5 Immature s.c. INJ PND 20 – 22 NA NA 3 6 6 estradiol benzoate 1 NA 24 hr 5 OVX s.c. INJ PND 68PND 5612 days7 6 6 Estradiol1 NA 24 hr 5MC_1MC_2MC_3MC_4MC_5MC_6MC_7 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0

1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 01 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 01 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 01 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 01 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 01 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 01 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 01 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 01 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 01 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 11 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 01 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0 1 1 1 1 1 1 0References lacking PMID numbers:

1) NICEATM_CERI_METI CERI, METI. 2006. Draft Report of Pre-validation and Inter-laboratory Validation For Stably Transfected Transcriptional Activation (TA) Assay to Detect Estrogenic Activity. Ver 2006.Oct.06 2) NICEATM_Brady_2000 Brady AM, Moffat GJ, Hall MG, Martens FK, Martens MA, and Nair R. 2000. An Assessment of In Vivo Estrogenic Activity of Butyl Benzyl Phthalate and its Principal Mammalian Metabolites. Toxic Substance Mechanisms 19: 1-24. 3) NICEATM_Goswami_2012 Goswami P and Kalita JC. 2012. Effect of Short Term Exposure of Butylparaben on Uterine Weight of Ovariectomised C3H Albino Mice. International Research Journal of Pharmacy 3 (9): 150-151.CERI, METI. 2006. Draft Report of Pre-validation and Inter-laboratory Validation For Stably Transfected Transcriptional Activation (TA) Assay to Detect Estrogenic Activity. Ver 2006.Oct.06

Brady AM, Moffat GJ, Hall MG, Martens FK, Martens MA, and Nair R. 2000. An Assessment of In Vivo Estrogenic Activity of Butyl Benzyl Phthalate and its Principal Mammalian Metabolites. Toxic Substance Mechanisms 19: 1-24.

Goswami P and Kalita JC. 2012. Effect of Short Term Exposure of Butylparaben on Uterine Weight of Ovariectomised C3H Albino Mice. International Research Journal of Pharmacy 3 (9): 150-151.Brady AM, Moffat GJ, Hall MG, Martens FK, Martens MA, and Nair R. 2000. An Assessment of In Vivo Estrogenic Activity of Butyl Benzyl Phthalate and its Principal Mammalian Metabolites. Toxic Substance Mechanisms 19: 1-24.