*Note that agenda times are approximate. For further information, please contact the Designated Federal

Officer for this meeting, Jim Downing via telephone: (202) 564 -2468 or email: downing.jim@epa.gov

**UNITED STATES ENVIRONMENTAL PROTECTION AGENCY**

**HUMAN STUDIES REVIEW BOARD (HSRB) PUBLIC**  **TELECONFERENCE /WEBINAR** 

**MEETING AGENDA**  **Fri day** **, August 15, 2014**  **2 :**  **0 0**  **p m**  **- 3**  **: 0**  **0 pm (Eastern Time)** ***** **HSRB MEETING FOR REVIEW AND APPROVAL OF THE**  **JUNE 11, 2014 HSRB MEETING**  **FINAL REPORT**  **HSRB WEB SITE http://www.epa.gov/osa/hsrb/ Docket Telephone: (202)**  **566 1752 Docket Number:**  **EP A** **– HQ** **– ORD** **– 201**  **4 -**  **0 564**  **Meeting l**  **ocation via telephone /Internet**  **only Dial in**  **number 86 6**  **- 299**  **- 3188; conference code 202**  **564 7189**  **https://epa.connectsolutions.com/hsrbtele 2**  **: 0**  **0 P**  **M Convene Meeting**  **and Identification of Board Members**

– Jim Downing

(Designated Federal Officer, EPA HSRB, OSA) **2 :**  **0 5**  **P M**  ***** **Meeting Administrative Procedures**

– Jim Downing, DFO **2 :**  **1 0**  **PM Meeting Process**  **–** Rebecca Parkin , Ph.D. , MPH (HSRB Chair) **2 :**  **1 5**  **P M**  **Public Comment s**  **2 :**  **2 0**  **P M**  **Board Discussion and Decision on**  **Final Report**  **–**Rebecca Parkin , Ph.D. , MPH

(HSRB Chair) The Board’s response to EPA charge questions presented at the June 11, 2014 meeting. **A published report by Paul et al**  **(1988) of an intentional exposure human study measuring the effects of small increases of dietary iodine on thyroid function.**  Charge to the Board - Science  Is this study

scientific ally

sound, providing reliable data?  If so, is this study

relevant for quantitative use in support of an assessment of the oral risk of exposure to iodine?*Note that agenda times are approximate. For further information, please contact the Designated Federal

Officer for this meeting, Jim Downing via telephone: (202) 564 -2468 or email: downing.jim@epa.gov Charge to the Board - Ethics  Does the study

meet the applicable requirements of 40 CFR part 26 subpart Q? **A published report by Gardner et al**  **(1988) of an i ntentional exposure human study**  **measuring the effects of low dose oral iodide supplementation on thyroid function.** Charge to the Board - Science  Is this study

scientifically

sound, providing reliable data?  If so, is this study

relevant for quantitative use in support of an assessment of the oral risk of exposure to iodine? Charge to the Board - Ethics  Does the study

meet the applicable requirements of 40 CFR part 26 subpart Q? **A published report by**  **Lemar et al (1995) of an intentional exposure human study**  **measuring the effects of chronic tetraglycine hydroperiodide water purification tablet use on thyroid function.**  Charge to the Board - Science  Is this study

scientifically

sound, providing reliable data?  If so, is this study

relevant to establish the reversibility of high dose iodine exposure?  Also, is this study

sufficient to establish that there are no sustained adverse effects from high dose iodine exposure? Charge to the Board - Ethic s  Does the study

meet the applicable requirements of 40 CFR part 26 subpart Q? **2 :**  **4 5**  **PM** ***** **HSRB Work Group on Return of Individual Research Results Report 2**  **: 5**  **5 P**  **M** ***** **Summary and Next Steps –**  Rebecca Parkin , Ph.D. , MPH (HSRB Chair) and Jim

Downing (DFO ) **3 :0**  **0 P**  **M** ***** **Adjournment**