111111111111111111111111111111111111111111111111111111111111 

# • OTS0000947 

# N One Source. One Search. One Solution. 

# INITIAL SUBMISSION: LETTER FROM ETHYL CORP TO USEPA RE TECHNICAL AND TOXICITY DATA ON BROMINATED FLAME RETARDANTS INCLUDING HEXABROMOCYCLODODECANE, * W/ATTCHMTS, DATED 5/23/88

23 MAY 1988

U.S. Department of Commerce 

### National Technical Information Service

# One Source. One Search. One Solution.

Providing Permanent, Easy Access to U.S. Government Information



# The National Technical Information Service is the Nation's largest repository and disseminator of government-initiated scientific, technical, engineering, and related business information. The NTIS collection includes almost 3million information products in a variety of formats: electronic download, online access, DVD, CD-ROM, magnetic tape, diskette, multimedia, microfiche and paper. Search the NTIS Database from 1990 forward 

### More than 600,000 government research information products have been added to the NTIS collection since 1990. All bibliographic entries for those products are searchable on the NTIS Web site at www.ntis.gov. Download Publications (1997 • Present) 

### NTIS provides the full text of many reports received since 1997 as downloadable PDF files. When an agency stops maintaining a report on its Web site, NTIS still offers a downloadable version. There is afee for each download of most publications. 

## For more information visit ourwebsite: 

# www.ntis.gov

**~';t~** U.S.. DEPARTMENTOF COMMERCE 

# . lJj" . TechnologyAdministration \ · / NationalTechnical Information Service .,.,,. Springfield, VA 22161CODING FORMS FOR SRC INDEXING Microfiche No. OTS0000947
FYI-OTS-0794-0947 84940000047

05/23/88 07/26/94 FYI

GULF SOUTH RESEARCH INST

INlTIAL SUBMISSION: LETTERFROMETHYL CORP TOUSEPARE TECHNICAL 

### AND TOXICITY DATA ONBROMINATED FLAME RETARDANTS INCLUDING DATED 5/23/88 Chemical HEXABROMOCYCLODODECANEMicrofiche Nc. 71 o I·· O!"tlct OF TOxzC SUBSTANCES CODING FORM FOR GLOBAL INDEXING ll No.
.ooe r.n. I

# FYI

**~K7qd-** """'



### /~·7 3 I Old Doe I.D. I 

### f Case No.Csl 

### II Dace Produced 

### rf!TT 6 Date Rec'd 6 I 7 Check One: DPublieat:l.on Otnternallv Generated Pub/Journal Name

Author sl I 

## Orooo. Nalll!!-1

**De~e/Div** I 

### P.O. Boil 131 Street NoJNamel I Cit11:l lSI Statel 

### l6



### ~ 

# ... MID llo. 7l I 19 I D & B NO. 11 I I Cont:ractcr 

### r Doc

**Tv~el**

# • • 

# •

**E.~.:b** Doc Tltle I

;

Chemical lla..,1300-ne= name \T 25

. 

## • REV. 7/27182 of Paooa I · 2 ! 4 5 Conf. Code • I 8 

# tJ DExternallv Gene=ated9 9 

### 10 ll 

### ' 12



### -l4 17 I Countrvl 16 20 21 22


### _,__ 23

CAS No. (lOll 24



## -

. .


### ... 

## .

### ETHYit CORPORATION Health andEnvironmentDepartme1 ETHYLTOWER.451 FLORIDA BATON ROUGE, LOUISIANA 70801



### Mr. 

### Robert Brink EXecutive Secretary TSCA Interagency Testing Committee (TS-792) May 23, 1988



# u. s. Environmental **Protect~on** 

### Agency 401 MStreet, 

# s.w. Washington, DC 20460 near Mr. 

### Brink: RE: 

### Decabromodiphenyl oxide, Octabromodiphenyl oxide, Hexabromocyclododecane, Pentabromodiphenyl oxide Ethyl Corporation is submitting the enclosed information in response to ITC's request for comments and data on brominated flame retardants. Ethyl is a manufacturer of decabromodiphenyl oxide {1163-19-5), octabromodiphenyl oxide {32536-52-0), pentabromodiphenyl oxide (32534-81-9), and hexabromocyclododecane (3194-55-6). For your information, we have enclosed the following technical and toxicity data: · 1. Saytex® Flame Retardants Product List {Ethyl Chemicals Group). 2. Technical Bulletins for decabromodiphenyl oxide, octabromodiphenyl oxide, and hexabromocyclododecane. 3. Material Safety Data Sheets for decabromodiphenyl oxide, octabromodiphenyl oxide, pentabromodiphenyl oxide, and hexabromocyclododecane. 4. Toxicology tests on: oecabromodiphen¥1..oxide: o Determination of DBDPO in rat livers (5/2/80) o 90-day subchronic study in rats [Tracor-Jetco] o Comedogenicity (9/21/81) o Eye irritation (3/24/86) 0 

### Human repeat insult patch test (6/4/75) 0 

### 13-week feeding study in mice (7/27/79) [Tracor-Jetco]

### Brink 1988 Octabromodiphenvl oxide: • 1-hour dus·c inhalation (1/31/841 o Two year dietary study in rates (?) 

### paper/Dow 

### o Acute oral toxicity (12/5/83) o 

### Dermal irritation (11/29/83) o 

### Eye irritation (12/5/83) o 

### Ames test (7/1/85) o 

### Dose Range Finding Study (12/7/84) o 

### Embryo/fetal toxicity (4/15/85) & 

### Review Hexabromocyclododecane: 

### o Arr;,s test (11/17/7B) 

### • Inhalation LCso/Dermal LCso (11/7/78) o

**Primar~** 

### dermal irritation/dermal corrosion/occular irritation/oral LDso (10/17/78) Pentabromodiphenyl oxide: o 

### Acute inhalation in rates (11/77) 

### o Acute oral toxicity in rates (11/84) • Ames test (12/85) o 

### Bromacnegenio (9/77) o 

### Acute toxicity (9/77) • ·Acute oral and percutaneous toxicity (9/77) o 

### Delayed hypersensitivity (10/77) o 

### Embryo/fetal toxicity (4/15/85) 

### In addition, under

**s~parate** 

### cover as attachment, Ethyl is submitting proprietary information which we are requesting the ITC to hold as "TSCA Confidential Business Information•. If you have any questions, please call me at (504l 388-7650.

LLW/ccj 2600r Sincerely,



# 1./.rv~~ Louise L. Weii Regulatory Affairs Associate

### !/ti'ii<'AIJ.eoi'(O

### cyc./o.£-tik



## ~'



# .,;:\-\.~\ 

# eo..

**~** 

# (

**~qse)**

MUTAGENICITY TEST OF Gl.S-S6-41A November 17., 1978

Tes:t: performed by Asya Shoi.cbet, Technician Certified by Kenneth Ehrlich, Project Supexvisor,

Department of Cytology and Applied BiochemistryThe sample, GLS-56-41A, was dissolved in dimethyl sulfoxide (10 mg/ml) and r:er,ted by the Ames Salmonella/microsome test procedure [Ames, B.N., J. McCann, and E. Yamasaki (1975) Mutetion Res. ;!_ 347]. The test was performed at levels of 2 to 1000

**~g** per plate and results are given ia the table. The number of S3lmctlella revertants obtained per plate can be compared to the control

**values~** With Salmonella strains TA1535, TAlOO, and TA1537 the number of revertants in sample-treated plates was equal to the number found for the untreated DMSO control plates. With TA98 tested in the presence of sample and liver homogenate, there was an

**~ncrease** of 20 colonies above DMSO control for plates treated with 40, 200, and 1000 pg

**~f** sample. The activity of the liver homogenate was

**~onfirmed** by its ability to convert benzo(a)pyrene and 9-aminoacridine to mutagenic products. Discussion Reversion of

**~he** Salmonella histidine auxotrophs is caused by mutagenesis. The different Salmonella strains have differing sensitivities to base-pair

**subst~tution** mutations and to frameshift mutation. Strains TAlOO and TA98 are particularly sensitive to most mutagenic substances but due to their intrinsically high spontaneous mutation frequency, small increases in· number of revertants compared to background levels must be interpreted cautiously. The fact that no dose-response reversion of TA98 was found, although there was a slisht increase compared to solvent control, may be considered evideuce that this increase is not due to mutagenesis. Furthermore, since the increased mutation frequency is less than 70 revertants more than control at the highest dose tested, the agent would be, at best, only an extremely weak mutagen. For these reasons we interpret the results to suggest that GLS-S6-41A is a nanmutagenic substance.

·: .;

### !illTAGENICI"fY TEST OF GLS-S6-41A Revertants 

### jzer jzlate pg{plate S9 TJ\98 TAlOO TA1535 TA1537 1000 35 

### 247 25 - 7 

## + 63 290 22. 7 

### 200 30 

### 240 26 7 

## + 61 257 21 7 

### 40 25 234 22 6 

## + 56 260 19 8 

### 2 .:. 

### 22. 218 20 6 

## + 47 242. 17 •8 

### Controls DMSO 0.1 1>\l, 

## + 42 234 21 10 

### Benzo(a)pyrene, 

## + 114 543 NT NT (5pg)
**N-methyl-N-n~troso N-n~troguall!idine,**  

### - NT NT 220 NT (Spg) 9-aminoaC.ridine 

## + NT NT NT 350 (Spg) NT= Not tested• 

### T<old ?{:<.<;fH 

# I "';.: . {'L,.t•... d:. 

# •

# ··~ 

# Consumer Product 

# Testing Bldg No. 2-158 1275 Bloomfield Avenue Fairfield, New Jersey07006



### CLIENT:
ATTENTION: 

### TESTS: TEST MA1ERIAL: EXPERIMENT REFERENCE NO. :

Date November 7, 1978 

### AI.P/CAL/nlrn • F IN A L Company_Incorporated (2011 575-7688 (2011 575-7669 

### REPORT Saytech Inc. 880

**~lain** Street _sayreville, Ne1< Jersey 08872 LaVerne J. Makfinsky Manager, Technical Compliance Inhalation 

### tc50 (Rat) 

### Dermal to50 

### (Rabbit) 

### GLS-S6-41A 78385-2 

# ('Jr. 1...\.-:}



# tL-tL~ ./

# r.J:_,:(..(. _, Christine A. Lewis, B.S. Laboratory Supervisor 

### Project

**Directo~** 

# IJ!l/7 //

# c. . {_ .. I . 

# . tc., ·-'



# .r~ t'c<



# ~..

# Le------ Allen L. Palanker • President



### . . ·.: ThisrepariiSsubmntedfor the



### eXclu:Siv~uSeofule petson,Partriershfp.



### or.Cor~mti~n**to~lto"m ii'i~** **add;~ssed:~~d ~~ith~~:ihe** **~~~i':'::-:i·.** norI henameoftheseLoborittorlesno.rofilnymP.mberofiisstein-maybeuSedincoful"eCilonwlihtheadveruslriQ'O;.ffiilenf'an\fpf'oduct :

**.·-~-"**

**Mf'""'"""'"'"·'~'i""' :"~'".~--"~::,··.~;~,;:.:~;**  !" , ., , -.:: :·; • :-,,,;· ; \';·.; _.·,.,, ·::;·;:.··.

**~** '-

**.,•,:;·~::~··:;":~·:.:.:'.:5:~:,:.:.•":~:..;_.,~-:i~**

### This report details :
a dermal LD50 study in albino rabbits and an inhalation LC50 study in albino rats performed at the behestof : Saytech Inc. 880 Main Sneet Sayreville, New Jersey 08872 The test material, supplied by : Saytech Inc. was received on : 

### September 15, 1978 and identified as : 

### GLS-S6-41A
and was used as indicatedin the Final Report Summaries. Study Interv?J : September 28, 1978 to November 2, 1978 All a,nimals are fed and watered ad libitum; with Wayne animal feeds used exclusively. Animals are received from Summit VIew Farm, Belvidere, New Jersey and are conditioned prior to use. Samples, raw data and final report copies are retained atthese laboratories unless

**otherwi~e** 

### indicated. Project Director and study supervisor are signatory to this report. Date of submission is recorded on title page. Names ol persons performingthese tests are recorded on raw data sheets and laboratory log books and are available upon request..Range Final Report Summary
DATE: November 7•. 1978 CLIENT: Saytech Inc. STUDY NO.: 78385-2 REFERENCE NO.: P. o. #00323 MATERIAL: GLS-S6-41A

Acute Dermal Toxicity 

### {LD5al Method: Follo.,ing 14-day range finding, albino rabbits in groups of six (3N:3P), lj abraded, 1.88
- 2.07 kg, highest dose level mechanically possible, single application dermally under occluded patch,

**ob~** se:rved fourteen days. Natei·ial used as received.. LD50 and 95% confidence limits according to the method of Litchfield and Wilcoxin, when possible. Upper limit possible due to mechanical and physical limitations is 8 g/kg.
Result: LD50' > 8 g/kg Dose Level

(g/kg} Sex l!dead/1/dosed %Mortality 

## o.s lF 0/l 0 Finding: 2.0 

### lF 0/1 0 Test Dosage: 5.0 

### lF 0/1 0 8.0 lF 0/1 0 8.0 3M:3P 0/3:0/3 0

Not a toxic material dermally to rabbits under conditions of this test.Consumer Product Testing Company, Inc.

. ' 

### . ' - ' ·'

.

**~-** ' 

### .Final Report Summary
DATE: November 7, 1978 CLIENT: Saytech Inc. STUDY NO.: 78385-2 REFERENCE NO.: P. 0. 1100323 MATERIAL: GLS-S6-41A

Inhalation Lc50 Method: Albino rats in groups to ten (SH:SF), 233-292 g, concentrations of 200 m&/liter (highest possible concentration) for one

**hour~** observed two weeks. 

### used as received. Result: 

### Lc50 > 200 mg/1



### Gross Dose Level (mg/1)

200 SM:SF Pathology: No gross changes observed. #dead/Udosed 0/5:0/5 exposed to chamber

Material

% 0



### Not a toxic material by 

### inhalation to rats under conditions of this test.

Consumer Product Testing Company, Inc.METHOD: Acute Dermal ToXicity in Rabbits (LD50) 

### Saytech Inc. 78385-2 

### ·Page 5

Acute dermal toxicity in rabbits was dete'imined according to 1he procedures suggested by Hagan: New Zealand white. rabbits, as indicated in the summary, were maintained under standard laboratory c;onditions**prio~** to administration of the test material. 

### Prior to determination of l D 50 single 

### animals, skin unabraded, were dosed at various levels to determinl! a range within which the LD50 could be determined. Animals were observed fourteen full days following application to determine mortality during this period. Following the range finding t!ie rabbits were dosed individually by dermal application under occluded patch at a dose level according to the results of the 11!--day range finding previously performed. Applications were made to the clipped backs ofsix (3M:3F) animals, 1/2 abraded, under I" x 1" gauze patches over 10% of the body surface. The dosed area was then covered with an impermeable plastic wrapping for 21!- hours, after which it was removed and the skin gently cleansed. Animals were returned to quarters where food and water were available ad libitum following the dose application. Animals were observed for signs of pharmacologic activity and drug toxicity at 1, 3, 6, and 24 hours postdosage. Observations were made daily thereafter to a total of fourteen days. Non-surVivors and animals sacrUiced at the end of the 14-day observation period were subjected to complete gross necropsy. LD together with 95% confidence limits was

### determineJ,**~here** possible, by the method of liti:hfield and Wllcoxin. The highest dose mechanically feasible to use is considered to be 8 g(ml)/kg bodyweight. Doses as high as 20 g/kg are used when instructed under EP/1. regulations; however, the data derived at, at these extraordinary high levels cannot be deemed as accurate as that derived at, at the lowerdose levels. 1Hagan, E.C. (1959) /\.cute Toxicity; Appraisal of the Safety of Chemicals in Foods, Drugs, and Cosmetics, pp. 17- 25. 2Litchfield, J.T. and Wilcoxin, F. (1949) Acute Toxicity; J. Pharm. & Ex. Ther•, pp. 96,

99.Inhalation

### LCao in Rats Saytech Inc. 

### 7S3SS-2 -Page 6

A group of adult Wistar-derived albino rats as 

### indicated in the summary1 

### was housed in a threecubic-foot plastic chamber for the single one (I)hour dynamic exposure pedod. The chamber was initially charged with test material at a concentration of 200 mg/1. Preconditioned supportive air was supplied at five (5) liters per minute, and the test material was presented from a dust generatorto continue a nominal chamber concentration of 200 mg/llter alr, over the one hour period. At the end of the

**one~hour** period, the animals were returned to individual quarters and observed daily for two weeks after which time they were sacrificed and autopsied.

### RESULTS: Acute Dermal Toxicity in 

### Rabbits Saytech Inc•

.-78385-2



### Page 7

**I~dividual** 

### results are presented in Tables 1 

## & 2. Acute Inhalation Toxicity Individual results are presented in Table 3. Summaries of all results are found preceding the text.Range Findin Dose Animal Number g/kg and Sex Table 1 Acute Dermal Toxicity in Rabbits GLS-S6-41A Bodyweight 

### Hours: Days:

(kg) I 3 

### 6 21! 

### 2 3 1.95 N N N N N N 2.03 N 4 5 N N 6 Saytech Inc. 

### 78385-2 

### -page 8

Bodyweight 7--14 (kg) N N 

### N 2.11 2.36 0.5 

### 2.0 5.0 

### 8.0 

### 1F 2F 3F 4F 1.94 N NO CHANGES OBSERVED 

### 2.28

a =abraded skin N =Normal D = Depression SD =Slight Depression XD = Severe Depiesslon + = Animal Death 

### 2.25 N

Comments: Animal 

### #1
- #4: Skin pliable and non-h:ritated. No gross changes observed. Draize Scores at 

### 24 Hours: Animal 

### #1 0/0 Animal 

### #2 0/0 Animal #3 0/0 Animal #4 0/0 

### 2.51

### Dose Animal Number g/kg 

### and Se>< 

### 8.0 

### !M 2Ma 3 Ma 4F 5Fa 6F

a 

### =abradedskin N =Normal D =Depression SD =Slight Depression XD = Severe Depression + 

### =Animal Death Table 2 Saytech Inc. 

### 78385-2 Page 9



### Acute Dermal Toxidty in Rabbits Bodyweight (kg) 

### 1.98 1.88 1.98 2.00 

### 2.07 2.06 GLS-S6-41A. Hours: Days: . Bodyweight I 3 6 21; 2 3 It 5 

### 6 7--14 

### (kg) N N N N N N 

### N NN N N 

### 2.52 N 

### 2.38 N

**~0** 

### CHANGES OBSERVED 2.42 N 

### 2.06 N 

### 2.19 N 

### 2.69

**~onunents:** Animal Ul ·• #6: 

### No gross changes observed. 

### Draize Scores 

### at 24 Hours: Animal #1 

### 0/0 A.nimal #2 0/0 Animal #3 

### 0/0 Animal 

### Y4 0/0 Animal #5 0/0 Animal #6 

### 0/0Table 3 

### Acute Inhalation Toxicity GLS-56-41A Dose Animal Number Bodyweight 

### Hours: Days: 

### mg/1 and Sex (grams) I 3 6 24 2 3 200 

### IM 284 N N N N N N 2M 292 N 3M 274 N 4M 264 

### N 4 5 N N Saytech Inc. 78385-2 ·page 10

Bodyweight 6 7-!11 (grams) N N N 366 344 330 320 5M 270 N NO CHANGES OBSERVED 284 

### GF 7F 8F 9F 10 F
N =Normal D = Depression SD 

### =Slight Depression XD 

### =SevereDepression + 

### = Animal Death 282 N 242 N 233 N 244 N· 242 N

Cornmentsj 

### Animal "1
- 

### DlO: No gross changes observed. 370 278 268 2i6 268

# Consunter Product Testing Bldg. No. 2-156 1275 Bloomfield Avenue Fairfield, NewJersey07006 Company Incorporated (201) 575-7688 (201) 675-768!)


### F I N A L R E P 0 RT CLIENT:
ATTENTION: TESTS:

TEST MA:fERIAL: EXPERUIENT REFERENCE NO. :



### Date 

### October 17, 1978 

### CAL/nlrn Saytech Inc. 880 Main Street Sayreville, New 

### Jersey 08872 

### LaVerne J. Makfinsky Manager, Technical Compliance Primary Dermal lxritation (Rabbit) Dexrnal Corrosion (Rabbit) Ocular Irritation (Rabbit) Oral 

### LDso (Rat) 

### GLS-S6-41A 78385-1

Christine A.

**Lewis~ B~S** .. 

### Laboratory Supervisor Project Director



# ~{fv.1rj.



# /l~Y,~ Allen L. Palanker President

Thisreport

### iSsUbmiUedfortheexclusiveuseof

### thep(:rson,Partnership, or

**corpara~lo**n

### tO

**who~**itis

### addreSSed.

**~d:n'uillt~'r tti~** **~;**

### :· northe

**n~,m~t**these Laboratorie-snOrofanymemberofitsslaff.maybeusedmccinnectiori.tNiltittieadvertising

### Orsai&OtB'nVP'rodUe1:-5

**··~** ...

**:~**........**~---.a"'-"'';,·**..
**:.~-~**.....**-~~--:--.:,:~.·.** ·' . •, . . . ·.. ·---,:_·· .. •',• '•• .. ·.-..

**~** _., .... ,..

### This report details : a primary dermal irritation study, a dermal corrosion study, and 

### an oculac irritation study in albino rabbits and _ 

## an oral 

## LDso study in albino rats performedat the behest of : Saytech Inc. 880 

### Main Street Sayreville, New 

### Jersey 08872 

### The test material, supplied by : Saytech Inc. was received on : September 

### 15, 1978 and identified as : GLS-S6-41A

and was used as indicated intheFinal Report Summaries. Study Interval : September 25, 1978 to October 13, 1978 All animals are fed and watered ad libitum; with Wayne animal feeds used exclusively. Animals are received from Summit View Farm, Belvidere, New Jersey and are conditioned prior 

### to use. Samples, raw data and final report copies areretained at these laboratories unless**otherwi~e** 

### indicated. Project Director and study supervisor are signatory to this report. Date of submission is recorded on title page. Names of persons performing these tests are recorded on raw data sheets and laboratory log books and are available upon request.

### Final Report Summary
DATE: October 17, 1978 CLIENT: Saytech Inc. 

### STUDY NO.: 78385-1 

### REFERENCE NO.: P. 0. 1100323 

### MATERIAL: GLS-S6-41A

**Prini.~ry** 

### Derma! irritation Method: Six rabbits, mixed sex, eachabradedand non-abraded, 0.5 ml single application under occluded patch, 24 and 72 hour observation. Material used as received. Result: PrimaryIrritationIndex:* 

## o.o

Not a primary dermal irritantto rabbitsundertheconditions ofthis

### test.



## * See Table 1Afor evaluation.

:: 

## .... ' 

### ·· consumer



### Prod~i:t 1'i.ititlgco'mpariy,

# rile:::

. >::'::-:::,..

**,_·f~:: :.:,::~::;'**  

### .

**·-~ ··;!,_:·:·}(.:i_~i::-::~:;:.'>.** 

### ·.'': ::; :·:.:::

**~- ,_-.--~--**  **'i~:;:**Final Report Summary
DATE: October 17, 1978 CLIENT: Saytech Inc. STUDY NO.: 78385-1 REFERENCE NO.: 

### P. 0, #00323 MATERIAL: GLS-S6-41A
Dermal Corrosion Method: Six rabbits, mixed sex, each non-abraded, 0.5 ml single application under occluded**pate~, ~and**  48..hour observation. Material used asreceived. Result: Prima:ry Irritation Index: 0.0 Corrosive: lf9 CFR 173.240 (a)(!): IS IS NOT X

Consumer Product Testing Company, Inc.Final Report Summary

DATE: October 17, 1978 CLIENT: Saytech 

### Inc. STUDY NO.: 78385-1 REFERENCE NO.: P. 

## o. #00323 MATERIAL: GLS-S6-41A

Ocular Irritation Method: Six rabbits, mixed sex, 1.8- 2.4 kg, 0.1 ml single administration, all with no wash for 24 hours and up toseven day observation. Materialused as received. · Result: Draize Score -----Day------- 

### 1 2 :3 

### 4-·--7 No Wash 6.2 2.8 0.3 0

**Mild~** transient 

### ocular irritant in rabbits under the conditions of this test.

Consumer


## Pro~uct·Testingcofiipa_,;y

## ,•Jrii:_..-... ····

. 

### . . ·-··' •'.•;' _,,

### .. , ... ' '· ...;· ··.·,·

### ..:." ···:

### FinalReport Summary_
DATE: October 17, 1978 CLIENT: Saytech Inc, 

### STUDY NO.: 78385-1 REFERENCE NO.: P. 0. «00323 MATERIAL: GLS-S6-41A
Oral LD50 Method: Albino rats in groups often (5M:5F), 192- 260 g, single dosed orally, (40 ml/kg top dose mechanically feasible) observedfourteen days. Material used as a 25% gravimetric suspension in cornoil. Result: Range Finding: 

### Test Dosage: LD

### 50: > 

### 10 g/l:g Dose Level (g/kg) 

### Sex fldead/lldosed

**~** 

### 1.0 1M 0/1 0 3.0 1M 0/1 0 

## s.o HI 

### 0/1 0 10.0 1M 0/1 0 10.0 SM:SF 

### 1/5:0/5 10


### Not a toxic material orally to rats under the conditions of this test.

Consumer ProductTesting Company, Inc.METHOD: 

### Saytecb Inc. 78385-1· Page 7

Primary Dermal Irritation in Rabbits A group of albino New Zealand rabbits as indicated in thesummary were used in this study. The tpst method was essentially that of Draize 

### et.al.
. Briefly paraphrased, it consisted of application of 

### 0.5 ml (0.5 g) of the test material to dipped areas of intact and abraded skin. The abrasions were longitudinal epidermal incisions sufficiently deep to 'penetrate the stratum corneum, but not so deep as to destroy the integrity of the derma. Applications were made under occlusive patches (211 x 211 gauze, CO\'ered by adhesive tape). Following application of the test material the 

### entire trunk of each animal was covered with an impermeable occlusive wrapping. The availability of the test siteto the animal is restricted by use of everted Elizabethan collars. The wrapping and test material were removed 2l/. hours following application. The sites were individually examined and scored separately for erythema and edema at 24 and 72 hours. The mean scores for 24 and 72 hour gradings were averaged to determine final irritation indices.

· 1Draize;,John H., Woodward, Geoffrey, and Calvery, Herbert·

## o,, "Methods for the Study of Irritation and Toxicity of Substances Applied Topically to the Skin and Mucous Membranes", J. Pharm. lt. Ex. Ther. 82, 377, (1944); ··, · ·• ' . .'

**~'.:** : '·,i: ··:-: ·..

**-~** .. \

### Dermal Corrosion in Rabbits 49 

### CFR 173.240 (a)U): 

### Sayt:ech Inc. 78385-1 Page 

### il

A group of six (6) albino New Zealand rabbits in a weight range of 1.8
- 2.4 kg, were used in this study. The test method was essentially that of Draize et.al. Bdefly paraphrased, it consisted of application of 0.5 ml (0.5 g) of the test material to clipped areas of intact skin. Applications were made under occlusive patches (2'1 

### x211 

### gauze, covered by 

### adhesive tape). Following application of the test materialthe entire trunk of each animal was covered with an impermeable occlusive wrapping. The animals were then immobilized. The wrapping and test material were removed 4 hours following application. The sites were individually examined and scored separately for erythema and edema at 4 and 48 hours. The mean scores for 4 and 48 hour gradings were averaged to determine final irritation indices. Corrosiveness seen at four and/or 48 hours alone indicates a corrosive material. Tissue destruction (corrosiveness) does not include merely sloughing of the epidermis, or erythema, edema orfissuring.

### Saytech Inc. 78385-1 Page 9

Primary Eye Irritationin Rabbits (FHSA) New Zealand rabbits as indicated In the summaty without ocular defects were used. The procedure followed was a modification ofthatused by Dr. J.H. Draize in Appraisal of The Safety of Chemicals in Foods, Drugs and Cosmetics, compiled by the staff of the Division of Pharmacology, Food and Drug Administration
- Department of Health, Education andWelfare. ·· In the technique of determining toxicity of substances to eye mucosa, observations of injuries were made

**~n** 

### the cornea, iris and the bulbar and palpebral conjunctivae. Numerical scores were assignep to lesions observed according to the Draize standard scoring system. In this system of scoring, the injuries to the cornea and iris account 

### for approximately eighty (80%) percent of the total score; tliese structures · are purposely weighted because of their vital role in vision. Healthy New Zealand rabbits were used for this test. One-tenth of a milliliterof each test substance was instilled in the right eye; the left eye,

**rem~ining** 

### untreated, served as a control. The treated eyes of allrabbits remained unwashed for 24 hours. Readings facilitated by hand-held lenses were made 1, 21 

### and 3 days after treatment, and up to seven (7) days when necessary.

1Dralze, John H., Woodard, Geoffrey, and C<i!very, Herbert

# o., i•MethodS for the Studyof Irritation and Toxicity of Substances AppliedTopically

**t~** 

### the Skin and Mucous Membranes", J. Pharm. &: 

### Ex. Ther. 82, 377; (1941fl.. ·. .. · .. . .

### Acute Oral Toxicity in Rats (!.050

## > Saytech Inc. 

### 78385-1 Page 10

Acute oral toxicity in rats was deterj"ined according totheprocedure suggested by Hagan. Wlstar-derived albino rats, as indicated in the summary were assigned to groups, and maintained under standard laboratory conditions for a minimL:m of seven days, and fasted overnight prior to adni'i,\istratlon of the test material. The rats were dosed individuallyby gavage, atgraded dose levels (following range finding) after which they were returned to quarters where food and water were 

### available adlibitum. Animals were observed for signs of pharmacologic activity and drug toxicity at I, 3, 6 and

**2~** 

### hours post- dosage. Observations were made daily thereafter to a totalof four.teen days. Animals sacrificed at the end of the 14-day observation period were subjected to complete gross necropsy. I.D

### 50 was calculated, (including the 9.5% 

### confidence limlt:s) wher'Zpossible, using the method of Litchfield and Wilcoxin except when the highest maximumdose mechanically possible (lfO 

### ml/kg) is used,

1Hagan, E.C. H9.59) 

### Acute Toxicity; Appraisal of the Safety of Chemicals in 

### Foods, Drugs and Cosmetics, pp. 17
- 2.5. 2Litchfield, J.T. andWllcoxin, F. (1949) J, Pharmacal.



## Exptl~ Therap. pp. 96; 99,

### RESULTS: Saytech 

### Inc. 78385-1 

### Page 11

Primary Dermal Irritation and Dermal Corrosion 

### in Rabbits The scoring scale used is presented in Table 

### 1. The individual results axe 

### px·esented in Tables 2 and 3. 

### Primary Eye Irritation in Rabbits

**T~l:lle** 4 detajls Scoring criteria. The individual 

### results are presented in Table 5. 

### Oral 

### tn50 

### in Rats Individual results are presented in Tables 

### 6 and 

### 7. Summaries of all results are found preceding the text.

### Saytech Inc. 78385-1



### Table 1 Scoring Criteriafor Skin Reactions Erythema and Edema Formation Very slight erythema (barely perceptible) Well-defined erythema Moderate to severe erythema Severe erythema (beet redness) to 

### slight eschar formation (injuries in depth) Total possible erythemascore 

### =4
Edema Formation 

### Page :12 

### {J-·

1

2 3 4



### Very slight edema (barely perceptible) l Slight edema (edges of area wellcdelined by definite raising) 2 Moderate edema (area raised approximately I mml 3 Severe edema (raised more than I mm and extending beyond area of exposure) 4 Total possible edemascore 

### =4 Total possible primary irritation score

# = 8

;.,...

### ·

### Score 

## c .5.0 and above 3.0 • 4.9 2.0- 2.9
1.0 -1.9 0.1- 0.9 

## o.o Table 

## iA Scale ofInterpreting Primary Dermal Irritation Scores (Draize- Rabbit) Interpretation Saytech Inc. 

### 78385:1 Page 13



### Corrosive- highly dangerous, warning labels must be used Primary Dermal Irritant .. highly dangerous, warning label must be used Potential 

### tOr severe irritation**~** warning**~abel** would be 

### advised · Potential for moderate irritation- may be irritating to humans under conditions similar to test (may consider warning label) Potential for mild irritation- possibly irritatingto some people under occlusive wrap conditions
- usually no warning required Potentialfor slight irritation- rarely irritatingto people -no warning required No irritation potential- no warning requiredTable 2 Primary Skin Irritation
- Rabbits SUMMARY OFSCORESFOR SKlN IRRITATION 

### GLS-S6-41A Rabbit Hours: 1

**2~** Number Skin .E 

### I Ed E 1 NA2 0 0 0 A:; 0 0 0 2 NA 0 0 0 A 0 0 0 3 NA 0 0 0 A 0 0 0 4 NA 0 0 0 A 0 0 0 

## s NA 0 0 0 A 0 0 0 6 NA 0 0 0 A 0 0 0 Average NA 0.0 

## o.o 0.0 A 

## o.o 

## o.o 0.0 Saytech Inc. 78385-1 

### Page i4

72



### I Ed 0 0 0 0 0 0 0 0 0 0 0 0 0.0 0.0 Combined Averages: 0.0 PrimaryIrritation Index: 0.0
IE/Ed= Erythemaand Edema 2NA =Non-abraded skin 3

A 

### =Abraded



### S~.in

### Table 3 Primary Skin Irritation
- Rabbits SUMMARY OF SCORES FOR SKIN IRRITATION GLS-S6-41A 

### Rabbit Hours:El 4 4& 

### Number Skin 

### I Ed E 

### I

1 

### NA2 0 0 0 2 

### NA 0 

### 0 0 3 

### NA .0 

### 0 0 4 

### NA 0 0 0 5 

### NA 0 0 0 6 

### NA 0 

### 0 0 Average NA 0.0 0.0 0.0 Combined Averages: 

### Saytech Inc. 78385-1 Page 15

Ed 0 0 0 0 0 0 

## o.o 0.0 Primary IrritationIndex: 0.0 1 E/Ed 

### =Erythema and Edema 2NA 

### =Non-abraded skinOcular Tissues Cornea

Iris Saytech Inc.

**78385~1**

Table 4 Eye Irritation Test Scaleof Weighted Scores for Grading the Severityof Ocular Lesions Page 16

Description Grading Opacity (A)

Opacity- degree of density (area which is dense is taken for reading) Scattered or diffuse area, details of iris dearly visible. I Easily discernible translucent areas, detailsof iris slightly obscured. 2 Opalescent areas, no details ofiris visible, size of pupil barely discernible. · 3 Opaque, irisInvisible. 4 Area of Cornea Involved (B)

One-quarter (or less), but not zero, Greater thanone-quarter, butless than one-half. Greater than one-half, but less than three·-quarters. Greater than three-quarters, up to whole area. I 

### ·2

3 4 Score equals A x B x 5 Total maximum = 80 

### -'ES:r:-::C..._rlormal, congestion, swelling, circumcorneal

Injection or all of these or combinations of any thereof), iris still reacting to light. Sluggish reaction is positive. I No reaction to light hemorrhage, gross destruction, (any or all of these). 2 Score equals A x 5 Total maximum 

### =10Ocular Tissues Conjunctivae 

### Saytecli Inc, 78385=1

Table 4 (cont'd.) Eye IrritationTest Scale of Weighted Scoresfor Grading the Severity of Ocular Lesions Page 17

Description Grading Redness (A)

Redness (refers to palpebral conjunctivae only). Vessels definitely injected above normal. More diffuse, crimson red, individual vessels not easily discernible. Diffuse beefy red. Chemosis (B) . I 2 

### 3 Any swelling above normal (includes nictitating membrane). I Obvious swelling with partial eversion of the lids. 2 Swelling with lids about half-closed. 3 Swelling with lids about half-closed to completely closed. II Discharge (C)

Any amount different from normal (does not include small amountobserved ininner canthus of normal animals). 1 Discharge with moisteningofthe lids and hairsjust adjacent to the lids. 2 Discharge with moistening ofthe lids and hairs and considerable area around eye. 3 Score equals (A + B + C) x 2 Total maximum 

### =20 Notei The maximum totalscore is the sum ofallscores obtained for the cornea, iris and conjunctivl!e. · ;;;Saytech Inc. Table 78385.-1 5 Page 18 Primary Eye Irritation- Rabbits SUMMARY OF EYE IRRITATION GLS-S6-41A Rabbit Cornea: Iris: Conjunctivae: Total Number Day AxBx5+ A X 5 + (A+B+C)xZ= Scores*

--··--------..-----No Wash Group--------------- 1 

### 1 0 0 0 (B) 1 0 0 2 

## z 0 0 0 1 0 0 

### 2 3 0 0 0 0 0 0 0 4 7 2 

### 1 0 0 0 0 0 0 0 

## z 0 0 0 0 0 0 0 

### 3 0 0 0 0 0 0 0 4 7 .· ..; 3 

### 1 0 0 0 (B) 1 1 0 4 

## z 0 0 0 0 0 0 0 3 0 0 0 0 0 0 0 4 7 4 I 0 0 1 (B) 1 1 1 11 

## z 0 0 0 l 1 0 4 3 0 0 0 0 0 0 0 4 7 5 

### 1 1 1 1 (B) 2 2 1 20 

## z 1 1 0 1 I 1 11 3 0 0 () 0 1 0 

### 2 4 0 0 0 0 0 0 0 7 6 

### 1 0 0 0 0 0 0 0 

### 2 0 0 0 0 0 0 0 

### 3 0 0 0 0 0 0 0 4 c 

### - 7 Average I 

### 6.2 2 

### 2.8 3 0.3 4 0 

### 7

*Total scorepossible/animal/observationinterval= 110 (B) = ,Blanched



### ...: :::;·

**;·~·>**- ·;.. :;"_,

### ..... 

### . .

;.:·' '··:. '• .. ...:· ;:. ....·._, 

# .-Range Finding Dose Animal Number g/kg and Sex



### 1.0 3.0 5.0 

### 10.0

N =Normal 

### 1 M 2

**~I** 3

**~I** 4 M

D 

### =Depression SO 

### =Slight Depression XD 

### =Severe Depression + 

### = Animal Death Table 6 AcuteOral Toxicity 

### GLS-56-41A SaYtech Inc. 

### 78385-1 Page 19

Bodyweight Hours: Days: Bodyweight

(grams) 1 3 6 24 2 3 .4 5 6 7-14 (grams)



### 234 

### 240 250 260 

### N N N N N N N N N N N 348 N 316 

### N NO CHANGES OBSERVED 340 N MO

Comments: Animal #1
- #4: No gross changes observed.



### ,. :·-: '";.

**~···** 'Table 7 Acute Oral Toxicity
Qose Animal Number g[kg and Sex 10.0 IM 2M 3M 4M 5M 

### 6F 7F 8F 

### 9F 10 F
N =Normal D 

### =Depression SO

# =Slight Depression XD 

### = Severe Depression 

### + = Animal Death Bodyweight (grams)

200 202 212 254 250 194 192 200 194 200



## * = 

### Hair moist, matted at 2 days GLS-S6-41A Hours:

1 3 6 2/f N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N Days: 2* 3 

### 4 5 NN N N 

### NN N N NN N N NN N N NN N N NN N N NN N N NN N N N N N N NN N N Saytech Inc. 78385cl Page 20

Bodyweight 6 7 

### [4 (grams) N N N 310 N N N 334 + 180 N N N 352 N N N 402 N N N 268 N N N 252 N N N 286 N N N 264 N N N 258

Comments: 

### Animal #1, #2, 

### #4
- #10: No gross changes observed. 

### Animal #3: Fibrous 

### tissue encasing heart and 

### lungs.PEACE OF MIND: SAYTEX" PERFORMANCE TESTED BROMINATED FLAME RETARDANTS

PRODUCT NAME CHEMICAL NAME CHEMICAL STRUCTURE APPEARANCE %Br TYPICAL DENSITY **T~A** ("Cat X% wt.loss) !sOLUBILITY (gl100g, 23"CII NOTES

FORM tmronnn:.tu PROPERTIES '"'"' ... ,: **~** .. **~ ~**  **~** \iiMtll : **/.C:HOI~** i IA:IIWQ.; lOU..IEI.I: I

REACTIVE FlAME RETARD\NTS SAYTEX RB-49 T£TfiAB!lOMO

**:~** """' l'tffiiAUCNtH't'DfliDE """"'" " mJ"CIJP ,., '" "' 219 - : 311 "" .w i 2.5 ___ :_ 2.!1 ..

' .

"' : """'

SAYTEXRB-79 **OIESTE~IEll ·~··-~**  ""'" **~-~ir-c'C** O:OLOfSAYTEXR0·(9 ... C. .. o-01 """" "' <.!10 107 "' '" "' '"' ,..,. "'

OS<TY

SAYTEX FR-1138 O!BROMOIIEOPENM. -1:- "'""" j ; **2~0**

GL.:OL """"'" " 9Slo105"CMP "" '" 1S3 uu .. <0..1 ; 55.1 , .. "

•. SAYTEX RB-100 TETnASROMO-

**~~:t~** """" 2'3 : :na ' in$01 : la.6

b!si'HaiOI..A """"'" " I'IB'CFP '" ,., "" "' '" ••

. . .

ADDIDVES FOR EXPANDED I EXTRUDED POlYSTYRENE SAYTEXHBCD <EJWJ"""'- .g. V.11ITE CYa.OOODECANf rowDER " l!"l'CMJI "" "' "' '" -: '07 "' fllsol : 72 <.1 .,

SAYTEXBCL-462 OIBROMOEtHYL-

. Q*" """" . OIBROMOCYCLOHEXAtlE """""" " n"CUP "" , .. "' "' '" "' ... 350 ., ,,

; ADDITIVESFORSTYRENIC I POLYOLEFIN I ENGINEERINGniERMOPlASTICS

. SAYTEX111 O:TABROLIO- .. **~--** OFF-WHitE 07 : 353

**OII'HEN'fl.OXI~** """'"" ro roto15D'CM? .,, "' "' "' "' '" """ "'

·····

**-~** . """"'"""'-

**~** \f} """ SAYTEX102 **Ol~OXICE**

**·~** fCIMJER " 30!1'CMI' "' '" 3S3 370 '" '"' tlsnl ! <0.1 <01 OS

. . . .......... :ll5 j **"~** '

SAYTEX120 **~ooo-** WH11E OIPHENOXYBEr.aetl:

**~** fCIM}BJ " 310"CIIP .,, "' "' "' '""' <0< <0< "

.. **~** '

EnM.D.Ebm- . "" UGHT

SAYTEX BT,93 · lETRAI;IOOMO-

.. **~1.** Qb ffi.LO.V 67 >4SO"CIIP '-" "" "' 4SO **~** '" >7W ""' <0> cO. I <01

l'ffiiWJWO£ "'"""' '

" : :n}HJ;OC ;

' SAYTEX BN-451 EnMEhebC- OI'F·WIIIfE DltlROMONDl180fli'WlE- rov.urn " Jl!)'C)JP 20S "" "' "' "" ,,,. .... 07 • <0.1 ''

OJCNlOOKIMIOE .
LtQUIDADDITIVE FLAME RETARDANTS

**-~** SAYID<115 PfNTABllOMO- .. **~** """"' - :-2,t:XJ10C(Icps,25"C cO.! : :101 ; I.D !

O!Pt£N"''t..OXIDE VISCOUS " **~Wv"C** Z21 "" ' '" "" '" "' "'

uouv SAYTEX125 **-~lf.r~r51** ""''" **2~~'C** '" 2S3 "' "' <0.1 WI <.01 "'

PilOPfii;JAftYClENO uooo " <.<15 "' I

' PLASliC!lER . .

- FlAME RETARDANTS FOR SPECIAL APPLICATION: -

SAYTEXVBR .. }{ CW<RUOWO NOTES ON SOLUBIUtvOI<TA:

-WiVI.BROMIOE 1\)!lOER " """" "" h5cl• **~ublo.<O** OOSglloog

... P>£SSUee> sol .. scJub!e,>IOOgiiOOg

.. **~** ; .. .,m Mr **""''"~'~** "d..,, **"'"'"'~-"'~** "·

# ETHYL 

# FLAME RETARDANT 

# L\PPLICATION MATRIX

APPLICATION 

# ~£.JJ;JkJJ~~~~~~/ '



# - SOLIDTHERMOPLASTICS ABS POLYSTYRENE (HIPS) NYLON POLYESTER (PBT/PET) POLYC'.ARBONATE POLYPROPYLENE POLYETHYLENE THERMOPLASTIC ELASTOMER THERMOPLASTIC POLYURETHANE 

### FOAMS

EXPANDED POLYSTYRENE RIGID POLYURETHANE FLEXIBLEPOLYURETHANE 

### WIREANDCABLE

SILICONE 

### PVC EPDM SYNTHETIC RUBBER HIGH PERFORMANCEJACKETS 

### THERMOSETS

EPOXY PHENOLIC UNSATURATED POLYESTER MOD ACRYLIC FIBERS 

### ADHESIVES AND COATINGS

TEXTILES PAINTS HOTMELTADHESIVES o =Reactive 11 ==Additive )

0 0



### ,, 0

**,,_,~~** '' 

# " 

# • • I
0 

# • •

0 0 0 0 0 

# • •

0 

# • 0 0 

# • • 0 

# " 

# " 

# .. 

# .. " 

# • • • 

# .. .. • 

# .. • 

# • 0 

# • 0 " II e 

# • •

# .. .. 

# ... 

# .. .. ., 

# ..

# .•I• 

# • " 

# " 

# • • 0 

# • •


# I "

# .. " 0 

# • 

# ... " " 

# ." • 

# • 

# . " 

# ..



# . "



# • 

# • " 

# • • 

# • • • • • • 0



# ...

• 0

c •

• e 0

·: ..

**~** . :.; ':

### OFFICES SALES: EthylCorporation Chemicals 

### Group

BromineChemicalsDivision EthylTower 451AorldaBoulevard BatonRouge, LA70801 Telephone: 504-38B-8609 800-526-3658 Telex:586431 ETHYLTWR 8TA Telecopier: **504~388-7686** 504-:388-7687 EthylSA 523Avenue Louise, Boite19 B-1050Brussels, Belgium Telephone: (32) (2)642-4411 Telex:84622549 Telecopler:(02) 648 4336 SaytexAameRetardants Europe EthylCorporation GoldlayHouse 114Parkway Chelmsford. EssexCM27PP Telephone: (44)(245)287·577 Telex: 995652ETHLBRG LatinAmerica Ethyl Chemicals, LatinAmerica 451 FloridaBoulevard BatonRouge, LA70801 Telephone:504-388-7460 Telex:586431or441 FarEast EthylCorporation BromineChemicalsDivision EthylTower 451 FloridaBoulevard BatonRouge, LA70801 Telephone: 504-388·7234 Telex:586431 ETHYLTWRBTR Telecopler:604-388-7886 504-388-7087 TECHNICAL: EthylTechnicalCenter Halogensand FineChem, 8000 G.SRt Avenue Baton Rouge, LA70820 P.O. Box14799 Baton Rouge, LA70898 Telephone:504-?68-5964 Telex: **7645B~ETC·BTR** Telecopler:_504-768·5607 Thelnlorrnalionpresenledhem!nisbelievedto beaccurateandreliable.

**~Is ~eseoted** wfthOUIguaranteeorrasponsibllityonltlepal'lofEthyl CorporatiOn.Furlher.oolhingconlainadshallbe takenasaninducementorrecommendatiOI'Ito manutaetureo.ruscanyOttnehereindescrobed

**ma1e~9**orpro't;nsse.cII'J**Viola\!~**'ofexistingor futuro patents.

**~·.** ··. · · · '·: 

### '' 

## :**::·Prlrue~~;~:~!** 

### .··,'·,.:,·.:: 

### . ' ' -

# ... c:c 

# z 

# - II. 

## 1&1 

# a: c:c 

# en 1&1 

# ... :J


# ... ... c:c 

# • Reproduced 

# by

# N I

# ZS National Technical Information Service Springfield, VA 22161 

# This report wasprintedspecifically foryourorder from nearly3million titles available in ourcollection. For economyand efficiency, NTIS does not maintain stock of its vast collection oftechnical reports. Rather, mostdocuments are custom reproducedfor each order. Documentsthatare notin electronicformatare reproducedfrom masterarchival copies and arethe bestpossible reproductions available. Ifyou have questions concerningthis documentoranyorder you have placedwith NTIS, please call ourCustomerService Departmentat 1-888-584-8332

# or(703) 605-6050. 

## About NTIS NTIScollects scientific, technical, engineering, and related business information-then organizes, maintains, and disseminatesthatinformation in avarietyofformats- including electronicdownload, onlineaccess, DVD, CD-ROM, magnetic tape, diskette, multimedia, microfiche and paper. The NTIS collection of nearly

## 3 million titles includes reports describing research conducted

# orsponsored byfederal agencies andtheircontractors; statistical and business information; U.S. militarypublications; multimediatraining products; computersoftwareandelectronicdatabases developed byfederal agencies; andtechnical reports prepared by research organizationsworldwide. For more information about NTIS, visitourWeb site at 

## http://www.ntis.gov. 

# • NTIS Ensuring Permanent, Easy Access to U.S. Government Information Assets<JCfOF"o



## l~ 

# '?it..,.,,


# .

**~.** 

# " ' 

# "

**~~** 

# ",/

..,.,.., of¥ 

### USDEPARTMENTOFCOMMERCE TechnologyAdministration NanonolTechnicollnformononService Splingfield,VA 22161 (703) 605·6000

111111111111111111111111111111111111111111111111111111111111

1111111111111111111111111


### SIN: M30 06-27-07 INVOICE: 1661132 SHIPTO: 1*979361 PAYMENT: CSH*V

**===================================================~** 

# I